SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 95%74752 Signaling by Insulin receptor 2252 127124 2251 23545 8074 51382 3416 2249 2887 2248 2247 57761 2246 533 2323 534 2322 152831 535 537 8823 10312 50617 5295 5296 5770 6464 2264 9296 5290 5291 5170 2255 9846 54106 3667 5140 5781 4893 245972 245973 27006 117145 3630 155066 2549 9114 51606 8660 5792 5594 5595 30849 10818 9550 523 525 526 527 1509 208 3643 528 8817 529 26281 8992 9965 5289 6654 90423 2254 3265 UNC93B1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 95%5602415 UNC93B1 deficiency - HSE 81622 7098 CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME%R-HSA-177162.3 Conjugation of phenylacetate with glutamine 116285 348158 DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME DATABASE ID RELEASE 95%5688399 Defective ABCA3 causes SMDP3 21 LONG-TERM POTENTIATION%REACTOME%R-HSA-9620244.3 Long-term potentiation 808 88 2891 2890 3084 1742 1741 1740 2906 1739 2905 815 2904 4900 6714 2903 816 4747 2902 817 818 PHOSPHORYLATION OF THE APC C%REACTOME%R-HSA-176412.4 Phosphorylation of the APC C 8881 64682 25906 11065 8697 7324 10393 29945 27338 119504 29882 891 246184 983 996 51434 51433 5347 51529 7321 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 95%5693579 Homologous DNA Pairing and Strand Exchange 7486 5982 5883 5884 5983 116028 3364 472 10635 672 675 84126 1111 83990 144715 83695 5810 7516 10111 5932 7517 7979 4361 7156 5890 9156 5892 4683 11073 580 10524 641 1763 545 6117 5984 5985 6119 79728 5888 6118 80010 5889 SIGNALING BY LTK IN CANCER%REACTOME DATABASE ID RELEASE 95%9842640 Signaling by LTK in cancer 5295 5296 5594 5595 6249 5290 5291 DISEASES OF THE UREA CYCLE%REACTOME%R-HSA-9955698.1 Diseases of the urea cycle 435 1373 10166 5009 57407 383 162417 445 ANTIMICROBIAL PEPTIDES%REACTOME%R-HSA-6803157.4 Antimicrobial peptides 245936 245937 245938 245939 6278 5068 5266 4057 6279 6037 613210 116842 613211 245930 728358 245932 245934 503841 671 641517 475 613209 55600 400830 51248 5657 10578 130120 729230 4069 1671 1670 245940 338324 6280 7097 7096 1191 55894 1668 57119 100133267 140683 140881 51297 57115 920 6039 6556 128859 1669 245913 8993 5320 503618 503614 245911 122665 117285 80341 1511 1235 114770 114771 1113 140850 1673 1672 1991 538 417 6406 3934 245927 245928 245929 81623 84659 3347 3346 820 149954 117159 5645 644414 92747 5646 504180 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%75105 Fatty acyl-CoA biosynthesis 109703458 60481 6319 47 9200 9524 79071 64834 2194 401494 23205 23305 79993 84869 253017 201562 51144 55301 11001 11000 54898 5538 31 197322 51703 2180 6785 22880 9374 3293 2182 81616 2181 51495 79966 83401 7923 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN CELL CYCLE AND PROLIFERATION%REACTOME DATABASE ID RELEASE 95%9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 4233 3065 25942 3094 1029 595 83439 1017 891 994 1026 1499 51176 6909 6932 5347 6934 RESPONSE OF EIF2AK1 (HRI) TO HEME DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9648895 Response of EIF2AK1 (HRI) to heme deficiency 2887 57761 8894 79094 1054 1051 23645 440 1965 27102 467 468 22809 1968 1649 REGULATION OF CDH1 MRNA TRANSLATION BY MICRORNAS%REACTOME DATABASE ID RELEASE 95%9764562 Regulation of CDH1 mRNA translation by microRNAs 4343 192669 23112 27327 999 26523 4613 192670 27161 57690 4609 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%R-HSA-450531.6 Regulation of mRNA stability by proteins that bind AU-rich elements 5580 9861 6233 11340 8570 9261 23404 3315 54512 3312 677 7316 7514 5578 55802 10213 5393 8741 7534 23016 8021 5073 5706 5707 5708 51010 5709 167227 1981 51013 207 5700 5701 3842 5702 7529 118460 5704 5705 5682 5683 5684 5685 5686 22894 5717 5718 5719 1994 1432 56915 11047 7538 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 8125 26986 54464 3304 5687 5688 5600 5689 6418 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%R-HSA-2980767.4 Activation of NIMA Kinases NEK9, NEK6, NEK7 5347 9133 140609 91754 10783 891 983 SMAC (DIABLO) BINDS TO IAPS%REACTOME DATABASE ID RELEASE 95%111463 SMAC (DIABLO) binds to IAPs 331 840 842 317 836 54205 56616 DEFECTIVE SRD5A3 CAUSES CDG-1Q AND KHRZ%REACTOME DATABASE ID RELEASE 95%4755579 Defective SRD5A3 causes CDG-1q and KHRZ 79644 ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME%R-HSA-173736.4 Alternative complement activation 629 718 1675 3004 EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME%R-HSA-9036866.4 Expression and Processing of Neurotrophins 5045 5046 5125 4803 INTERLEUKIN-33 SIGNALING%REACTOME%R-HSA-9014843.4 Interleukin-33 signaling 90865 9173 RHOBTB1 GTPASE CYCLE%REACTOME%R-HSA-9013422.4 RHOBTB1 GTPase cycle 7431 9475 8452 6434 8654 10250 9886 27316 23013 9352 6093 3183 11329 56254 2873 79869 5930 10574 51138 9318 10576 4646 1627 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME DATABASE ID RELEASE 95%3134975 Regulation of innate immune responses to cytosolic DNA 3661 340061 29110 147945 81844 23220 7311 81030 11277 7314 6737 51428 6233 7316 22954 CS DS DEGRADATION%REACTOME%R-HSA-2024101.6 CS DS degradation 1462 2990 23553 3373 112937 8372 3074 3073 63827 1634 3425 79411 411 2720 3423 633 1464 89944 1463 10675 BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME DATABASE ID RELEASE 95%77305 Beta oxidation of palmitoyl-CoA to myristoyl-CoA 3030 37 3032 SIGNALING BY LIGAND-RESPONSIVE EGFR VARIANTS IN CANCER%REACTOME%R-HSA-5637815.3 Signaling by Ligand-Responsive EGFR Variants in Cancer 11140 3320 1950 5335 2549 867 7311 1956 7314 6233 7316 5295 6464 6654 4893 5290 3265 DISEASES OF MITOTIC CELL CYCLE%REACTOME%R-HSA-9675126.4 Diseases of mitotic cell cycle 8881 64682 25906 11065 8697 7324 10393 7027 29945 1021 595 27338 1019 119504 29882 1017 894 896 1871 246184 1026 898 996 1870 51343 51434 6502 51433 1616 9134 1028 1027 546 7029 1869 5925 51529 7321 TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS%REACTOME DATABASE ID RELEASE 95%9616222 Transcriptional regulation of granulopoiesis 5914 474382 1053 1050 54145 861 865 1441 1017 1026 51176 1051 4609 7027 1019 7029 1869 8970 8331 4297 8337 128312 8334 8335 2672 2033 8370 2624 55766 8968 4602 7913 8341 8342 8347 8348 94239 8345 3013 3570 8340 2313 688 8338 255626 6256 6774 3021 653604 3018 3017 85236 3014 6886 6688 8349 LXR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 95%9024446 LXR-mediated signaling 6319 6257 23028 9682 2172 27329 6907 80820 8648 54659 79718 9619 64241 64240 7376 9612 10062 8204 8841 9611 19 1071 221656 341 344 4343 29116 2033 2874 192669 23112 346 27327 2194 347 348 26523 5346 5105 192670 10123 27161 55818 57690 6256 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 95%446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 140838 29906 207063 6675 56052 81849 440138 79053 84920 51046 5973 51005 10610 6483 22845 2720 6482 6484 55808 6487 6489 64841 5476 10020 3098 79087 256281 6480 144245 256435 10825 55577 2673 8813 27090 30815 9945 85365 197258 8818 7264 29929 4351 10195 4597 338596 8790 29926 29925 55343 29880 1798 79796 10559 84620 2762 91869 8869 5238 116150 5372 5373 55907 8128 57171 26503 282969 199857 54187 80896 54344 79868 9526 79947 7903 4758 10402 129807 4759 79644 MITOCHONDRIAL RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME DATABASE ID RELEASE 95%9937383 Mitochondrial ribosome-associated quality control 54471 6150 55168 64949 28973 65080 51642 54998 5018 10573 11222 128308 51649 9553 64960 92259 64963 63875 64965 64968 55052 55173 64969 51250 51373 26284 51650 51253 60488 51258 219927 29074 56945 28998 64975 79590 64976 64979 115416 64978 23107 28957 64928 4706 7818 51263 29088 51021 57129 54534 51023 51264 51069 84545 78988 122704 65993 64981 10240 64983 3396 63931 26589 54460 6182 6183 118487 51073 116540 740 124995 54148 116541 55037 29093 9801 51116 10884 54948 51318 91574 64432 65003 64951 65005 65008 28977 90480 51081 DAG1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 95%8931838 DAG1 glycosylations 84197 9486 11041 9215 29954 113829 729920 120071 2218 146664 10329 79147 148789 84892 10559 10585 55624 1605 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH OGG1%REACTOME DATABASE ID RELEASE 95%9656249 Defective Base Excision Repair Associated with OGG1 4968 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME DATABASE ID RELEASE 95%193648 NRAGE signals death through JNK 29 8874 64857 572 57449 4803 389337 445328 2245 23263 50650 26574 221472 5599 9639 10672 10276 55701 5879 9459 9138 4168 27237 7074 6655 11214 5924 7204 9500 55160 23365 9181 128272 57580 4804 10018 26230 121512 1894 10451 7410 84904 100271715 26084 23370 25791 89846 9826 54848 9828 7409 23229 22899 50649 6654 8997 6453 7984 VITAMINS%REACTOME%R-HSA-211916.3 Vitamins 1594 1592 1591 340665 120227 56603 NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866904.4 Negative regulation of activity of TFAP2 (AP-2) family transcription factors 7341 7022 79047 7021 83741 51741 7329 339488 7020 284252 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME DATABASE ID RELEASE 95%1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 8453 9861 7323 6233 7322 2034 126374 84962 9978 3091 112399 112398 8994 7316 6921 6923 64344 54583 10213 7428 7321 5706 5707 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 5687 5688 5689 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE DURING HIV INFECTION%REACTOME%R-HSA-167160.4 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 2071 2966 6829 2965 2963 2962 2068 5434 5435 5436 5437 5438 5439 2968 2967 404672 5430 5431 5432 5433 902 5440 8732 5441 4331 8731 1022 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME DATABASE ID RELEASE 95%111459 Activation of caspases through apoptosome-mediated cleavage 331 840 842 317 836 54205 PROTEIN FOLDING%REACTOME%R-HSA-391251.3 Protein folding 10383 8786 10382 55294 112714 55135 55970 402 9628 60 7846 84790 10471 5201 5202 6499 84617 5082 11328 54331 2767 10238 10517 59345 26330 10574 1155 8841 84261 347733 10576 2769 7277 7278 7157 22948 63971 2782 26985 26224 79861 81027 2776 54461 10528 5203 10681 5204 8877 10564 898 9134 908 113457 6950 7203 2793 2792 7280 2791 1460 2790 26272 1459 6905 2788 1457 2787 2786 83752 2785 26234 2784 2783 51764 10693 6468 10376 10694 6902 2629 26190 10575 80086 26270 6904 6774 6903 9630 94235 51807 6000 22803 10381 8787 7411 INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS%REACTOME%R-HSA-176033.4 Interactions of Vpr with host cellular proteins 23636 9631 7175 9972 11097 23279 8086 23511 53371 8480 79023 79902 10762 8815 5903 348995 9883 6396 129401 9688 291 292 57122 293 23225 3836 4927 3159 23165 11168 55746 8021 55706 RHO GTPASES ACTIVATE FORMINS%REACTOME DATABASE ID RELEASE 95%5663220 RHO GTPases Activate Formins 60 348995 6396 57122 55746 23279 79023 79902 5903 54908 6232 8655 25909 8379 9183 1063 1062 91010 9184 1060 1855 991 151648 55166 752 1058 79019 998 151246 9735 1857 1856 23332 57591 79003 55055 81565 22919 348235 5048 23421 220134 57082 23380 57405 51143 147841 4085 64105 401541 10403 387 81624 388 389 54820 80776 701 54821 378708 286205 1781 23122 1780 23002 79172 1778 81930 55920 84643 114793 29984 3796 5216 5217 9793 5879 91687 57551 79682 5905 1783 5501 3688 83540 80152 2491 5519 332 55143 699 6722 11243 51466 71 3619 140735 5515 11004 5516 5518 9212 25936 11130 64946 79980 10726 1729 5525 5526 55839 5527 5528 7514 5529 5347 6249 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME%R-HSA-195399.3 VEGF binds to VEGFR leading to receptor dimerization 7422 2324 3791 7424 7423 2277 2321 5228 GLUTAMATE AND GLUTAMINE METABOLISM%REACTOME DATABASE ID RELEASE 95%8964539 Glutamate and glutamine metabolism 57494 29920 2746 27165 284716 2744 883 2752 5831 4942 2806 2747 65263 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME DATABASE ID RELEASE 95%5654227 Phospholipase C-mediated cascade; FGFR3 5335 8823 8074 8817 2249 26281 2247 2246 2254 ALTERNATIVE LENGTHENING OF TELOMERES (ALT)%REACTOME%R-HSA-9006821.3 Alternative Lengthening of Telomeres (ALT) 1616 546 INTESTINAL SACCHARIDASE DEFICIENCIES%REACTOME%R-HSA-5659898.4 Intestinal saccharidase deficiencies 3938 6476 HIV TRANSCRIPTION ELONGATION%REACTOME DATABASE ID RELEASE 95%167169 HIV Transcription Elongation 2071 2966 6829 2965 2963 2962 2068 5434 5435 5436 5437 5438 5439 2968 8178 2967 22916 404672 25920 5430 4686 5431 51224 5432 6924 5433 7936 902 6827 6749 9150 6917 1025 51497 7469 11198 904 6921 6923 5440 5441 4331 1022 NEPHRON DEVELOPMENT%REACTOME DATABASE ID RELEASE 95%9831926 Nephron development 153572 5455 28514 79192 182 3975 54361 7490 3172 3955 7484 6928 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 95%389958 Cooperation of Prefoldin and TriC CCT in actin and tubulin folding 10383 10382 112714 60 7846 84790 10471 5201 5202 84617 908 113457 6950 7203 10574 7280 347733 10576 7277 7278 22948 79861 81027 5203 10693 5204 10376 10694 10575 80086 51807 10381 7411 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME%R-HSA-69052.6 Switching of origins to a post-replicative state 1017 9861 6233 9978 7316 10213 51529 7321 5706 8881 64682 5707 25906 5708 11065 8697 5709 7324 10393 29945 27338 119504 5700 5701 29882 5702 246184 898 996 5704 51343 51434 6502 5705 51433 5682 5683 9134 5684 5685 5686 5717 5718 5719 11047 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 4172 8454 4173 4174 5687 4175 5688 4176 4171 5689 990 84515 51053 5000 5001 890 8900 6500 23595 23594 81620 4998 4999 NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME%R-HSA-9034013.2 NTF3 activates NTRK3 signaling 4916 4908 SLC-MEDIATED TRANSPORT OF OLIGOPEPTIDES%REACTOME%R-HSA-9959399.1 SLC-mediated transport of oligopeptides 51296 6564 1497 121260 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 95%392517 Rap1 signalling 23108 6494 5894 5906 5908 5909 5566 5567 11069 5568 7529 10411 10235 10125 7534 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 95%1475029 Reversible hydration of carbon dioxide 760 771 761 762 763 765 766 768 759 377677 23632 11238 SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME%R-HSA-426486.6 Small interfering RNA (siRNA) biogenesis 6895 192669 7247 26523 192670 27161 23405 8575 7257 TRP CHANNELS%REACTOME%R-HSA-3295583.4 TRP channels 7220 7442 7222 7224 7223 7226 7225 59341 79054 55283 26133 54795 8989 55503 4308 162514 255231 57192 80036 56302 51393 57113 29850 54822 140803 DEVELOPMENTAL LINEAGE OF PANCREATIC DUCTAL CELLS%REACTOME%R-HSA-9925563.2 Developmental Lineage of Pancreatic Ductal Cells 3918 284217 3908 3909 7448 3910 3911 3912 3913 3914 3915 2335 10319 MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 95%390648 Muscarinic acetylcholine receptors 1129 1128 1133 1132 1131 TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME%R-HSA-1299308.2 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) 9424 3775 10089 SARS-COV-1 MODULATES HOST TRANSLATION MACHINERY%REACTOME DATABASE ID RELEASE 95%9735869 SARS-CoV-1 modulates host translation machinery 6230 6232 6210 6231 6234 6235 6191 2197 6193 6192 6194 51065 140032 6205 6227 6204 6207 6229 6206 6228 1915 6209 6208 6188 6187 6223 6201 6189 6222 6233 6203 6224 6202 3178 6218 6217 3921 DEFECTIVE LFNG CAUSES SCDO3%REACTOME DATABASE ID RELEASE 95%5083630 Defective LFNG causes SCDO3 4851 4853 4854 4855 3955 PTK6 PROMOTES HIF1A STABILIZATION%REACTOME%R-HSA-8857538.4 PTK6 promotes HIF1A stabilization 3091 1956 120892 5753 1839 10457 DEFECTIVE TPR MAY CONFER SUSCEPTIBILITY TOWARDS THYROID PAPILLARY CARCINOMA (TPC)%REACTOME%R-HSA-5619107.4 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 23636 9631 7175 9972 11097 23279 8086 23511 53371 8480 79023 79902 10762 5903 348995 9883 6396 129401 9688 57122 23225 4927 2646 2645 23165 55746 8021 55706 REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME DATABASE ID RELEASE 95%73943 Reversal of alkylation damage by DNA dioxygenases 221120 51008 84164 10973 121642 79068 54890 ARG1 VARIANTS CAUSE HYPERARGININEMIA%REACTOME%R-HSA-9956514.1 ARG1 variants cause hyperargininemia 383 RHOBTB GTPASE CYCLE%REACTOME%R-HSA-9706574.4 RHOBTB GTPase Cycle 11140 3320 23221 29766 55023 7919 5756 7431 9475 124540 8452 3326 6434 87 8654 10250 9886 27316 23013 9352 6093 3183 11329 908 56254 2873 79869 5930 10574 51138 9318 10576 4646 1627 71 UNWINDING OF DNA%REACTOME%R-HSA-176974.4 Unwinding of DNA 4171 51659 84515 4172 4173 64785 4174 8318 4175 9837 4176 84296 MTOR SIGNALLING%REACTOME%R-HSA-165159.8 MTOR signalling 1981 207 7529 51719 6198 5562 5563 6794 7248 5564 5565 389541 6194 29904 28956 1975 57521 55004 8649 51422 10670 6009 1978 1977 5494 5571 64121 64223 92335 153129 2280 81617 84335 53632 2475 7249 55437 58528 208 10542 10325 RAC3 GTPASE CYCLE%REACTOME%R-HSA-9013423.2 RAC3 GTPase cycle 29 11135 4952 1969 10006 55914 4168 7074 5295 3688 5296 55004 8773 50508 7444 6510 2909 9743 57584 392 9341 394 5062 395 1536 10811 397 1535 10458 55843 10979 9815 7879 55845 4688 4689 10298 10652 3998 9235 9710 81839 23092 55971 143872 347902 1829 4810 55619 85360 8936 10424 10787 5881 27 10152 998 64411 7204 124056 2010 23344 182 143098 2889 29127 57580 4983 613 857 8987 3930 55789 51347 7410 26050 3071 23380 4162 7112 7037 5058 10163 28964 80728 22865 23191 653361 81624 23592 23075 116984 55114 27035 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%R-HSA-3642278.3 Loss of Function of TGFBR2 in Cancer 7046 7048 7040 DEFECTIVE CYP27B1 CAUSES VDDR1A%REACTOME DATABASE ID RELEASE 95%5579014 Defective CYP27B1 causes VDDR1A 1594 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME DATABASE ID RELEASE 95%2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 4001 3024 29855 25842 8091 7290 23523 57634 3009 3008 3007 3006 3005 5925 3159 7157 INTERLEUKIN-36 PATHWAY%REACTOME DATABASE ID RELEASE 95%9014826 Interleukin-36 pathway 8808 27179 27177 56300 26525 84639 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 95%376172 DSCAM interactions 57453 1630 9423 1826 FORMATION OF THE HIV-1 EARLY ELONGATION COMPLEX%REACTOME DATABASE ID RELEASE 95%167158 Formation of the HIV-1 Early Elongation Complex 2071 2966 6829 2965 2963 2962 2068 5434 5435 5436 5437 5438 5439 2968 2967 22916 404672 25920 5430 4686 5431 5432 5433 7936 902 6827 9150 51497 7469 5440 5441 4331 1022 SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME DATABASE ID RELEASE 95%480985 Synthesis of dolichyl-phosphate-glucose 256281 29880 CDC42 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013148 CDC42 GTPase cycle 11135 4296 10928 115557 23048 26030 80243 54874 79658 83478 7454 9754 7456 115703 2040 139818 201176 10788 57514 51133 26286 9901 64333 9644 116985 23268 147179 57480 117289 57522 3895 9912 50855 51306 8826 343578 9411 50619 221178 101059918 124997 58504 257106 1123 23526 5063 4650 153478 57144 644150 393 55240 396 398 84364 5337 29062 91010 148170 51291 3728 144402 8976 85440 90627 752 8476 56990 81704 998 23348 7204 89839 57569 23580 23365 10395 10435 128272 92799 57580 10160 9578 25894 57572 121512 23513 1894 10602 10451 128239 7410 56924 23380 26084 25791 89846 9826 81624 23229 22899 50649 6453 7984 29 8874 64857 23002 2245 23263 221472 114793 9639 10672 9459 4168 27237 7074 5295 5296 5924 55004 8773 2909 9743 57584 392 9341 394 5062 397 10458 9815 7879 10298 10652 81839 23092 143872 55619 85360 64411 29127 4983 613 857 3930 55789 7112 7037 5058 28964 80728 116984 55114 SIGNAL TRANSDUCTION BY L1%REACTOME DATABASE ID RELEASE 95%445144 Signal transduction by L1 1459 1457 1956 5594 5595 7410 3690 3680 5879 4684 3685 5058 3674 3897 3678 8829 3688 5604 5605 1460 MGMT-MEDIATED DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 95%5657655 MGMT-mediated DNA damage reversal 4255 MATURATION OF PROTEIN E%REACTOME%R-HSA-9683683.4 Maturation of protein E 7316 7311 7314 6233 ECM PROTEOGLYCANS%REACTOME DATABASE ID RELEASE 95%3000178 ECM proteoglycans 3679 3693 8785 3694 4146 3371 4060 7040 6678 375790 3687 7143 4593 7148 2331 63923 3381 176 3339 1311 4148 1758 1834 5054 3673 3688 1297 1404 8516 4038 5802 1462 63827 1634 633 3913 1463 3915 284217 3908 3909 7448 3910 3911 3912 1605 3690 3680 4684 3685 3674 7043 54829 7042 1299 1298 SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME DATABASE ID RELEASE 95%4551638 SUMOylation of chromatin organization proteins 3065 9189 8535 6304 6045 7341 1107 83746 648 8554 6015 7329 3066 23468 9759 1912 1911 23512 23314 80012 57332 348995 84733 9883 6612 6396 7703 129401 6613 9688 57122 23225 4927 23165 8021 55746 55706 23636 9631 7175 9972 11097 23279 8086 23511 53371 8480 79023 79902 10762 5903 8370 SIGNALING BY APC MUTANTS%REACTOME DATABASE ID RELEASE 95%4839744 Signaling by APC mutants 5515 5516 5518 5525 5526 8312 2932 5527 324 5528 1452 5529 139285 5519 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 95%70171 Glycolysis 5566 5567 5568 26330 5519 5515 5516 5518 348995 9883 6396 129401 9688 5528 57122 7167 23225 5223 5224 4927 230 80201 23165 283209 2821 8021 55746 2027 55706 2026 3098 23636 5214 9631 7175 5230 5232 9972 3099 11097 132789 23279 2597 8086 3101 23511 387712 53371 5210 8480 5211 79023 5213 79902 2023 10762 10007 5903 226 83440 229 669 5207 5208 5209 2646 2645 DEFECTIVE BINDING OF RB1 MUTANTS TO E2F1,(E2F2, E2F3)%REACTOME%R-HSA-9661069.2 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 7027 1021 595 1019 1017 894 896 1026 1871 898 1870 9134 1028 1027 7029 1869 5925 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%R-HSA-3065678.4 SUMO is transferred from E1 to E2 (UBE2I, UBC9) 7341 6612 6613 10055 25950 7329 10054 NFE2L2 REGULATING TUMORIGENIC GENES%REACTOME%R-HSA-9818030.1 NFE2L2 regulating tumorigenic genes 2033 1950 4851 374 596 4780 5154 598 1387 6667 7975 CO-INHIBITION BY BTLA%REACTOME%R-HSA-9927353.2 Co-inhibition by BTLA 151888 8764 5777 5781 TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME DATABASE ID RELEASE 95%380095 Tachykinin receptors bind tachykinins 6870 6863 6865 6866 6869 LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME%REACTOME DATABASE ID RELEASE 95%9005891 Loss of function of MECP2 in Rett syndrome 2874 79718 3065 25942 9612 814 808 8841 9611 5566 6907 ACTIVATED NTRK2 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 95%9028335 Activated NTRK2 signals through PI3K 2549 5295 4915 4909 627 5290 ALANINE METABOLISM%REACTOME DATABASE ID RELEASE 95%8964540 Alanine metabolism 2875 ESTROGEN-DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR-MEMBRANE SIGNALING%REACTOME DATABASE ID RELEASE 95%9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 6722 1950 1956 595 207 5594 5595 7039 2353 685 127933 255324 2069 2002 208 1027 10000 2309 7514 5747 374 596 1839 WNT5:FZD7-MEDIATED LEISHMANIA DAMPING%REACTOME DATABASE ID RELEASE 95%9673324 WNT5:FZD7-mediated leishmania damping 5879 10811 124056 1535 1857 1856 7474 8324 3725 1855 5599 27035 ATP SENSITIVE POTASSIUM CHANNELS%REACTOME%R-HSA-1296025.4 ATP sensitive Potassium channels 10060 3764 6833 3767 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME DATABASE ID RELEASE 95%170660 Adenylate cyclase activating pathway 113 114 115 2774 107 108 109 196883 111 112 PLATELET HOMEOSTASIS%REACTOME%R-HSA-418346.4 Platelet homeostasis 55970 5023 5024 5025 5026 8654 22953 5739 2983 2268 2982 6546 5138 4842 54331 6547 4843 3710 4846 59345 10335 5152 5153 5593 80228 5519 487 488 489 84876 5027 27094 2782 7804 6717 7222 5321 9127 5515 490 7225 491 5516 808 492 5518 493 27345 10681 338 3778 3779 5175 6786 5136 5525 6543 5526 5051 2977 5527 2778 5528 10846 5529 57113 3708 3709 10242 50940 2793 2792 1432 5781 2791 2790 2788 5777 2787 2786 2785 2784 2783 51764 94235 SYNTHESIS OF WYBUTOSINE AT G37 OF TRNA(PHE)%REACTOME%R-HSA-6782861.3 Synthesis of wybutosine at G37 of tRNA(Phe) 129450 55253 55039 9836 57570 127253 LIPID PARTICLE ORGANIZATION%REACTOME DATABASE ID RELEASE 95%8964572 Lipid particle organization 345275 1149 128486 161247 29923 63924 RECYCLING OF EIF2:GDP%REACTOME%R-HSA-72731.4 Recycling of eIF2:GDP 8894 8893 1965 8891 8892 8890 1967 1968 SUPPRESSION OF PHAGOSOMAL MATURATION%REACTOME%R-HSA-9637687.3 Suppression of phagosomal maturation 51606 7311 7314 7879 9146 6233 11151 3837 26276 5868 7316 4843 3836 VARIANT SLC6A20 CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME%R-HSA-5619101.4 Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) 54716 REGULATION OF BACH1 ACTIVITY%REACTOME%R-HSA-9708530.5 Regulation of BACH1 activity 6502 9978 64839 571 7316 7311 7314 6500 8454 6233 7975 SLC-MEDIATED TRANSPORT OF AMINO ACIDS%REACTOME%R-HSA-9958863.1 SLC-mediated transport of amino acids 54716 23428 92745 6511 6533 206358 84889 6509 120103 55089 117247 340024 10991 6506 6505 6507 9056 9057 153201 6520 8501 6541 123096 81539 8140 23657 55117 56301 11254 6512 6539 11136 6519 124935 54407 6510 REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 95%169911 Regulation of Apoptosis 5706 5707 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 5690 5691 5692 5693 5694 79658 7311 7979 5695 7314 9861 6233 5687 5688 5689 7316 115209 4976 10213 5062 ERKS ARE INACTIVATED%REACTOME%R-HSA-202670.4 ERKs are inactivated 5515 5516 5594 5518 5595 5528 5598 51231 1849 1848 5519 1846 1845 MATURATION OF SPIKE PROTEIN%REACTOME%R-HSA-9694548.5 Maturation of spike protein 7841 29801 25921 253832 6480 51201 55741 256435 1650 11320 51125 4247 51304 27090 100128731 4249 6185 7991 4124 4245 6184 25834 23193 58505 201595 2530 79844 821 11253 5589 51114 746 1603 3703 10610 6483 6482 6484 6487 84061 11282 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 95%391908 Prostanoid ligand receptors 11251 5731 5732 5733 5734 5737 6915 5739 5729 DEUBIQUITINATION%REACTOME DATABASE ID RELEASE 95%5688426 Deubiquitination 9146 4609 9986 6478 100287238 100287478 9861 81847 6233 9738 8767 9736 57506 728386 3091 161725 4738 23172 367 7316 51651 9868 8658 93973 4194 10213 8314 7345 8678 7347 8313 4193 5706 57646 5707 84101 5708 4086 63891 5709 7353 4087 4088 100287327 4089 5700 100287205 5701 55593 9099 5702 9097 100287441 5728 5704 23032 5705 64750 114785 5682 100288520 5683 114548 5684 4092 5685 154 5686 10617 5717 7375 5718 392188 5719 93624 11274 55252 5071 11047 10868 57559 5713 10869 5714 23252 7128 5690 89122 5691 8473 5692 4792 5693 10392 5694 317772 7311 23586 5695 79594 7314 79913 85235 4303 54617 84142 5687 92552 5688 9577 100287404 5689 221937 64426 55031 23358 83844 123228 57695 79589 5886 84132 4798 5887 8239 10600 86 7706 9100 9101 25862 100287513 7046 27005 7048 23326 90865 7040 80124 55288 60 993 79931 401447 10254 84282 645836 6881 6885 8027 125476 55611 54764 51377 57599 5423 408 80351 409 1080 7187 7186 7189 7157 79155 100287178 29761 54891 10474 29086 56957 7874 221613 1643 9804 9929 171023 8850 645402 8975 8295 2625 51720 92815 8724 10454 8969 8607 9817 219333 440689 64127 3054 100287144 84749 78990 126119 55777 23770 1540 8737 6314 329 91833 7528 3607 51616 84196 9960 8078 64135 377630 2099 6502 29844 728419 63967 114803 330 10318 7415 9958 7417 8970 7416 8331 7419 991 2648 8337 4287 128312 79184 8334 100287364 8335 55432 283899 2033 83444 27430 8517 10445 8341 8342 8347 8348 8345 3013 8340 8338 255626 387 3018 3017 85236 8349 3416 221656 8312 324 7321 983 672 7979 580 890 8900 DAG1 CORE M3 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 95%8932505 DAG1 core M3 glycosylations 84197 29954 148789 84892 10585 1605 CREATINE METABOLISM%REACTOME%R-HSA-71288.3 Creatine metabolism 6539 1158 6535 6534 2593 1152 1160 2628 6538 548596 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 95%72203 Processing of Capped Intron-Containing Pre-mRNA 4904 10914 10915 10594 7737 10236 11325 55749 10482 27238 63932 9130 10921 11338 2733 29894 4236 79706 57819 4116 84081 6430 25949 7884 6432 6431 79171 1660 22794 8175 23524 1655 4809 10450 6427 91603 6426 9939 6429 57703 10212 6428 1659 23658 8189 51729 5356 55094 27336 27339 79165 1665 26121 84991 10465 163859 25804 3181 3188 65109 3187 3185 3184 57721 79753 55660 2521 7536 9716 51503 51747 3192 3191 23517 3190 23759 5499 9295 10569 79622 83443 51634 7307 51759 3178 7919 1977 6233 3312 7316 5440 5441 8021 2963 2962 5434 5435 5436 5437 5438 5439 5430 5431 5432 5433 7311 7314 22803 6434 10250 27316 3183 79869 5930 51428 348995 9883 6396 129401 9688 57122 23225 4927 23165 55746 55706 23636 9631 7175 9972 11097 23279 8086 23511 53371 8480 79023 79902 10762 5903 51639 53938 9984 8896 81608 57187 10898 84324 23283 11066 51645 10772 84321 11193 9877 24148 55696 24144 55339 8899 64852 55100 1479 26097 1478 1477 85437 23020 85313 143884 10992 9879 8563 9410 10081 8683 10084 11051 9775 23398 9092 3550 22985 55234 55110 55599 8559 5725 58509 10523 6936 9785 10291 59286 29107 10978 79576 199746 53981 84248 9416 8449 56339 10179 58517 728343 10181 8106 51690 51692 51691 57794 5500 51213 11157 10189 8233 4670 22938 64895 151903 51340 10713 51585 5511 55702 5514 22826 22827 10284 5411 10283 153527 8241 5093 5094 60625 84811 22916 51593 23350 4686 79228 10286 10285 988 55954 11017 9584 9343 6632 154007 6631 9589 10929 57461 84844 56259 51362 6625 6627 6626 6629 135295 6628 220988 10262 27258 84950 10946 23450 23451 54883 6634 56949 6633 6636 5546 6635 6638 84271 6637 9128 9129 10907 26017 9360 80145 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-HSA-141430.3 Inactivation of APC C via direct inhibition of the APC C complex 8881 64682 25906 11065 8697 7324 10393 29945 27338 119504 29882 246184 996 51434 51433 4085 9184 991 51529 7321 701 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME%R-HSA-425397.6 Transport of vitamins, nucleosides, and related molecules 402 64078 23443 23169 2030 23568 55343 389812 10999 51000 11046 10559 3933 51248 347734 286256 7355 8884 376497 28965 347 222962 3177 9197 9153 9154 84912 55315 291 292 293 SUNITINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669934.2 Sunitinib-resistant KIT mutants 3815 AMINE LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-375280.4 Amine ligand-binding receptors 1812 134864 319100 134860 9038 3354 3352 3274 3351 1129 3350 1128 1133 146 1132 147 1131 148 3269 11255 4935 154 9287 3363 3362 150 3361 151 3360 152 59340 153 155 3358 3357 3356 3355 1816 83551 1815 1814 1813 GENERIC TRANSCRIPTION PATHWAY%REACTOME%R-HSA-212436.13 Generic Transcription Pathway 5915 5916 146713 143686 84661 341359 3977 11091 63970 349075 2660 163049 1327 163051 4839 5928 5929 163050 654254 900 901 51755 340252 1329 905 30832 65243 285676 4850 1340 79891 3516 4848 2669 1337 4849 79898 5931 5933 5934 1339 4605 23619 1351 65018 1350 9070 100287226 1349 79885 1347 388536 1346 1345 55215 10308 124411 10781 10780 4852 10782 65251 1108 162966 162967 162963 1121 100289635 22974 388569 83933 388566 388567 4869 5970 388561 3549 284309 10769 125965 284307 284306 400720 58500 10520 4878 10765 58508 3562 3559 3558 1378 147741 27166 253639 10971 5978 5979 284370 115509 90233 29117 1392 57677 3329 57678 10018 3569 1386 79230 339327 339559 146434 26053 124446 353274 6601 6603 6602 6605 158431 6604 57209 91584 7710 57693 387032 613227 27153 27154 57459 133383 7700 4435 4436 219749 10370 6872 5300 6874 6873 220992 995 51003 5775 7712 442319 7711 79813 79818 10135 4208 10138 266743 6880 6883 4221 6882 6884 148254 4697 51499 7341 7022 55615 79047 6875 7021 6878 83741 5305 51741 8812 6877 7329 339488 6879 7020 5308 284252 90827 7728 2290 7323 23429 7743 148266 148268 80818 9978 2289 342926 23660 56950 6921 55869 6923 7733 54778 11200 79837 5440 7738 6648 5441 9915 4331 23439 730087 1022 7752 7994 2071 6662 2966 6829 7753 2064 2965 2063 2963 441234 2962 54541 2068 5434 55634 5435 51276 5436 353088 5437 7745 5438 56729 5439 5325 6657 2968 7988 2967 7748 404672 5430 136051 5431 138474 5432 10127 5433 7761 902 7760 91975 7762 8851 114026 3164 339500 4004 4488 1460 100129543 7755 4005 1459 5579 7757 55888 1457 7770 8861 219578 7771 7532 5111 7531 7773 7533 8621 90874 162972 23410 161882 148213 23411 3174 148203 51058 196528 148206 7525 5588 7767 55659 7766 7769 55657 7768 6696 5366 730291 126231 55663 579 55422 8626 6446 10794 10793 10795 7539 5371 7552 7551 9975 285267 9734 285268 7556 581 255403 79862 9968 9969 7549 57615 90649 100131827 7561 129685 7157 7562 7565 122809 7567 7566 4292 355 356 7559 9739 8409 6241 94115 7571 5395 7574 9997 7576 29959 51412 7568 80196 54925 8431 7582 7101 25 7587 6498 7586 6497 6258 253260 7581 84108 9757 8427 7594 7596 9534 8445 7592 126382 142 84333 199777 53615 9540 7122 4091 23368 4094 85456 2908 197320 84124 54715 5196 9794 9310 8463 6046 9314 64769 25799 1820 440519 440515 10273 54971 9337 162239 7159 181 9572 51230 90809 54989 152687 55835 10046 8013 79370 8493 7161 170960 57343 57103 125919 147948 147949 9358 170959 26048 55170 80108 90390 80110 221044 83860 9125 6097 342132 285971 7181 7182 6096 6095 1876 144455 1875 1874 26013 282890 344787 9377 8289 92595 55193 10919 27113 80139 168417 2737 5519 1647 332 2736 79175 133746 6722 93474 84527 4929 387893 84765 58484 5515 57154 83667 5516 3845 5518 2516 9212 133522 9167 121340 58491 58492 1437 1436 147923 27300 59348 5527 147929 340385 8089 7422 112858 8085 84775 3622 2539 2538 27165 2744 8178 25920 51224 6924 7936 6827 6749 9150 6917 1025 51497 7469 11198 904 28514 182 3172 8454 890 8900 6500 5566 7222 4851 4853 4854 4855 2645 5562 5563 6794 7248 5564 5565 389541 28956 57521 55004 8649 51422 10670 6009 5494 5571 64121 64223 153129 53632 2475 7249 58528 10542 10325 857 3930 7040 55240 3674 3678 5054 8535 6045 1107 83746 648 6015 3066 23468 9759 1912 1911 23512 23314 80012 57332 84733 7703 8312 2932 2821 1387 6667 814 627 7039 2353 10000 2309 3725 367 4194 4193 4086 4087 4088 4089 9099 5728 64750 4092 4303 8239 86 6881 7874 1643 8850 2625 7528 51616 2099 2648 5781 4287 3630 2593 5594 5595 208 5770 5170 808 2891 815 2904 6714 2903 816 817 22938 818 51529 7321 8881 64682 25906 11065 8697 7324 10393 29945 27338 119504 29882 891 246184 983 996 51434 51433 7486 5982 5883 5884 5983 116028 3364 472 672 84126 1111 83990 144715 83695 5810 10111 5932 7979 4361 7156 9156 5892 4683 11073 580 10524 641 1763 545 6117 5984 5985 6119 5888 6118 80010 4904 3815 4233 3065 25942 1029 595 83439 1017 1026 1499 51176 25904 6932 100506658 6934 168374 5816 6908 29028 1051 10419 284459 10891 90317 155061 10650 2308 10413 121274 1649 55571 4609 54487 4343 284443 192669 6910 23112 155054 27327 90589 2572 26523 147694 2571 192670 1482 27161 80778 57690 246175 6929 9861 147686 6233 147687 90338 3654 100129842 4986 4988 64065 22869 90576 7316 90333 7514 6940 2100 285349 10213 1493 353355 81856 7534 1490 81857 5608 6938 5706 100131980 5707 79788 5708 283337 4512 5709 4513 4514 22835 3683 207 4773 5700 1263 5701 1020 114787 5702 80317 7529 146540 84914 5704 84924 5705 57547 5682 2104 5683 57541 5684 2103 5685 27287 5686 2101 55367 5717 834 5718 835 5719 3676 839 1432 90594 6720 11047 1030 90592 5713 84911 5714 146542 5690 10628 5691 80314 5692 1024 5693 843 5694 604 7311 847 5695 4778 7314 4790 440077 84701 3458 1278 5687 1277 5688 5600 5875 5876 5689 4322 56242 57573 147657 57336 440073 10848 864 57335 317 79109 50943 54205 6750 3486 3484 23327 199704 632 2146 5045 389114 51123 7832 10013 637 84289 639 10014 10498 11105 162655 146198 117608 640 405 4336 6515 406 10025 23309 7862 6772 5443 7621 2177 2176 1081 650 892 51385 171392 7633 148156 3276 665 341947 79943 7626 7625 10001 11335 7627 3280 6790 25946 5465 126375 374900 55762 79973 79733 5457 8726 5458 7638 348327 7652 23774 29079 57711 55534 5467 5468 5469 55778 10224 8738 25925 1956 5241 7027 1021 91875 1019 7421 894 163732 896 221785 374928 898 200845 148103 3064 51343 6502 694 79755 1616 54457 9134 55786 1027 79759 4149 140612 7029 158399 1869 10432 5925 8970 7673 25937 8331 169270 4297 463 8337 128312 79744 9862 8334 6595 8335 6597 619279 2033 6599 8370 6598 2624 55766 30818 8968 728957 57060 4602 94241 7913 84449 8341 117584 8342 84441 8347 7678 8348 117581 94239 8784 8345 3013 7692 7695 7694 8340 5275 7697 7699 8338 163227 255626 163223 6256 79088 3021 84676 653604 28984 3018 84436 3017 84671 8794 85236 3014 8795 8550 6886 54807 6688 8793 8349 8797 5914 163255 474382 23269 59269 54811 54145 861 55900 865 54815 5052 9656 6257 9891 8317 11059 80095 6907 9422 7001 10172 7004 79718 9668 7003 7005 201514 84246 7376 9612 51564 94039 5079 23019 8841 9611 115196 50484 23493 51333 9443 9441 126070 9442 2874 7025 26974 65988 348 23466 25888 5105 9440 728927 23460 51586 23462 10398 9439 10397 10155 286075 126068 374879 127396 2811 2810 51592 55713 10168 9464 114907 84838 26152 26155 163081 9219 374655 7296 9477 7057 112950 8148 57472 7291 57474 83737 91120 7050 7295 169841 83744 163071 390927 147837 1749 7068 8396 7067 1998 1514 204851 1997 1513 84626 80264 1750 29883 1515 26149 63934 57492 163087 79027 144348 7082 9021 3958 2623 60436 84883 4800 4801 4802 2626 90075 3726 2877 84874 84870 80032 113835 93134 199692 163059 23067 9282 28996 92285 92283 256051 PARADOXICAL ACTIVATION OF RAF SIGNALING BY KINASE INACTIVE BRAF%REACTOME%R-HSA-6802955.4 Paradoxical activation of RAF signaling by kinase inactive BRAF 673 8826 2244 2266 7414 8844 10256 54518 5894 22866 5906 4140 5908 7450 5037 2243 7094 1445 7529 369 283455 408 409 4893 4296 3845 808 5594 5595 3690 3674 815 6714 5604 816 5605 817 8315 818 5245 2335 3265 3717 FRS-MEDIATED FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 95%5654700 FRS-mediated FGFR2 signaling 2252 27006 2255 2251 8074 2249 2248 2247 10818 2246 10817 8823 8817 26281 5781 6654 4893 2254 3265 SODIUM PROTON EXCHANGERS%REACTOME%R-HSA-425986.4 Sodium Proton exchangers 84679 6550 6553 389015 6548 6549 10479 285195 23315 FLT3 SIGNALING THROUGH SRC FAMILY KINASES%REACTOME DATABASE ID RELEASE 95%9706374 FLT3 signaling through SRC family kinases 2322 2534 6850 3055 3932 2323 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 95%159854 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 2621 2147 632 5045 2158 2155 8858 5624 5627 2677 2159 BRANCHED-CHAIN KETOACID DEHYDROGENASE KINASE DEFICIENCY%REACTOME%R-HSA-9912481.1 Branched-chain ketoacid dehydrogenase kinase deficiency 594 10295 1629 1738 593 LIPOPROTEIN METABOLISM%REACTOME%R-HSA-174824.6 Lipoprotein metabolism 163 2 29801 23491 5045 57552 5046 4018 5125 8435 213 335 336 337 4864 5566 6646 5567 27329 4547 26291 5568 55908 3990 8720 64788 9619 1175 1173 3949 7376 345 84699 10062 3069 51599 55911 3988 19 1071 341 344 29116 346 348 6233 338 7316 7311 7314 9388 26119 51360 338328 1213 1211 7436 51128 319 81693 255738 51129 10577 91289 5034 4023 8029 160 161 116519 VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME DATABASE ID RELEASE 95%196843 Vitamin B2 (riboflavin) metabolism 79581 54 5167 55312 113278 80308 55065 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME%R-HSA-432047.3 Passive transport by Aquaporins 4284 360 361 375318 362 363 364 282679 343 366 358 359 89872 NTF3 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME%R-HSA-9025046.2 NTF3 activates NTRK2 (TRKB) signaling 4915 4908 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 95%446353 Cell-extracellular matrix interactions 10979 87 6251 7016 2316 9459 5829 29780 3611 55742 54751 55679 3688 7408 3987 2318 DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 95%5610780 Degradation of GLI1 by the proteasome 5706 5707 5708 5709 83737 5700 5566 5701 5567 5702 5568 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 9861 8454 6233 5687 5688 9978 5689 7316 6500 10213 8650 51684 8945 2735 ENHANCED CLEAVAGE OF VWF VARIANT BY ADAMTS13%REACTOME%R-HSA-9845619.1 Enhanced cleavage of VWF variant by ADAMTS13 7450 11093 DEFECTIVE SLC36A2 CAUSES IMINOGLYCINURIA (IG) AND HYPERGLYCINURIA (HG)%REACTOME%R-HSA-5619041.4 Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG) 153201 TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION BY EBF2%REACTOME%R-HSA-9844594.2 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 57504 655 57459 5468 4086 9112 1149 64641 3065 63976 7350 54815 23090 3192 4089 53615 8648 5928 10891 1107 5931 3066 133522 5465 1346 6256 83401 1108 9219 TRNA PROCESSING IN THE MITOCHONDRION%REACTOME%R-HSA-6785470.6 tRNA processing in the mitochondrion 51095 3028 54931 9692 60528 PURINE SALVAGE%REACTOME%R-HSA-74217.7 Purine salvage 161823 4860 270 271 3251 272 51292 132 100 353 1633 2766 1716 SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME DATABASE ID RELEASE 95%2142696 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) 239 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%R-HSA-442720.6 CREB1 phosphorylation through the activation of Adenylate Cyclase 114 107 808 5573 5566 5575 5567 5576 5577 5568 5613 DEFECTIVE MGAT2 CAUSES CDG-2A%REACTOME DATABASE ID RELEASE 95%4793952 Defective MGAT2 causes CDG-2a 4247 CA2+ PATHWAY%REACTOME%R-HSA-4086398.5 Ca2+ pathway 55970 83439 1499 51176 6885 6932 6934 54331 3710 59345 5593 4343 192669 2782 23112 27327 26523 192670 27161 808 57690 10681 815 5578 3708 3709 2793 2792 2791 2790 5145 4772 7481 2788 5534 5592 2787 5158 2786 5148 7976 2785 7855 51701 2784 8322 2783 5330 51764 5331 5530 8323 5532 2780 23236 2535 2775 7474 94235 DEFECTIVE SLC27A4 CAUSES ICHTHYOSIS PREMATURITY SYNDROME (IPS)%REACTOME DATABASE ID RELEASE 95%5619108 Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) 10999 TRNA PROCESSING%REACTOME DATABASE ID RELEASE 95%72306 tRNA processing 29894 348995 9883 6396 129401 9688 57122 23225 4927 55253 23165 55039 9836 55746 57570 127253 55706 23636 129450 9631 7175 9972 11097 23279 8086 51095 23511 3028 53371 54931 8480 79023 9692 60528 79902 10762 5903 134637 81605 10898 79897 55687 51002 51367 11102 91801 54517 54913 10775 115708 80746 54482 84705 24140 51493 60487 54802 54888 1478 54920 10785 10940 4234 8270 339487 283989 55621 283742 152992 64172 63892 348180 116461 2058 83480 10248 11260 113179 79691 25821 79693 1653 55006 55644 81890 84520 51605 93587 90353 10978 221078 79042 23536 1787 5901 79074 10799 10557 54974 84267 57604 51504 10556 54901 51637 112858 8021 DEFECTIVE SLC20A2 CAUSES IDIOPATHIC BASAL GANGLIA CALCIFICATION 1 (IBGC1)%REACTOME DATABASE ID RELEASE 95%5619111 Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) 6575 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME DATABASE ID RELEASE 95%9670621 Defective Inhibition of DNA Recombination at Telomere 1616 546 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 95%380270 Recruitment of mitotic centrosome proteins and complexes 10383 10382 1781 1778 7846 5566 9793 7277 5518 9738 9662 7840 11064 22994 22995 7283 10733 80321 203068 114791 55722 1454 1453 3320 55125 9814 85378 11190 115106 79441 95681 10426 27175 1069 653784 54801 983 10142 9702 10540 8655 5347 5108 11116 4751 29922 55142 22897 27229 54930 5116 79959 80184 93323 5577 728642 23354 22981 440145 8481 10844 80254 121441 55755 23332 984 7532 10806 10121 7531 55559 8636 22919 11258 80097 5048 84131 4957 55835 54820 ACTIVATED NTRK3 SIGNALS THROUGH RAS%REACTOME%R-HSA-9034864.2 Activated NTRK3 signals through RAS 6654 4893 4916 4908 3265 ION CHANNEL TRANSPORT%REACTOME%R-HSA-983712.4 Ion channel transport 478 1179 479 150159 51761 53822 7439 5894 53826 51802 6446 53828 22802 219931 286410 9635 338440 57198 480 1193 481 57194 2281 482 483 486 1188 10786 285175 65266 65268 487 65267 51248 488 285335 489 495 496 144453 7220 10110 7442 9914 7222 10079 6717 7224 55107 7223 6263 7226 490 6262 7225 491 94015 492 57130 59341 493 6261 79054 55283 23678 2040 26133 540 28962 54795 5205 8989 55503 55515 40 4308 41 162514 255231 266675 57192 23400 374868 80036 56302 54831 51393 23120 57113 55129 50636 29850 54822 9311 140803 5350 161003 259232 84239 7809 23250 444 284525 196527 57719 5348 5349 10345 57205 1831 344905 10396 538 6340 6588 80727 148229 27032 57578 121601 51076 53373 6337 6339 6338 245972 245973 155066 9114 51606 9550 523 525 526 527 528 529 8992 90423 127124 23545 51382 11059 533 534 535 537 10312 50617 9296 808 6233 815 7316 816 817 818 7311 7314 65125 63982 1187 203859 1186 23200 1185 1184 1183 1182 1181 133308 1180 476 79895 57101 23327 477 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%R-HSA-2173791.3 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 7046 7048 7311 57154 7040 7314 2280 6233 23370 7316 50848 5590 387 57530 56288 50855 CELL DIVISION%REACTOME DATABASE ID RELEASE 95%68884 cell division 9493 10735 23063 23383 5885 10274 10112 5347 25836 8243 9126 23244 23047 ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME DATABASE ID RELEASE 95%8847993 ERBB2 Activates PTK6 Signaling 2069 1950 2064 1956 9542 10718 5753 145957 1839 3084 685 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME DATABASE ID RELEASE 95%110329 Cleavage of the damaged pyrimidine 474382 54145 8970 8331 8337 128312 8334 8335 4968 8370 55766 8341 8342 8930 8347 8290 8348 55247 94239 23583 8345 26277 3013 252969 25913 8340 7013 65057 7014 8338 79661 255626 54386 6996 4913 3018 3017 85236 3014 8349 ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME%R-HSA-5624958.4 ARL13B-mediated ciliary trafficking of INPP5E 56623 5147 200894 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MLH1%REACTOME DATABASE ID RELEASE 95%5545483 Defective Mismatch Repair Associated With MLH1 4292 5395 TRIGLYCERIDE METABOLISM%REACTOME%R-HSA-8979227.2 Triglyceride metabolism 2170 80168 84649 2820 2169 116255 2168 2167 150379 8228 346606 5566 2172 11343 5567 646486 5499 3991 5568 64900 646480 2713 2712 2710 51099 150763 23175 10226 5501 5346 57678 857 5500 9663 8694 392636 2173 2171 ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866907.3 Activation of the TFAP2 (AP-2) family of transcription factors 7022 2033 7021 83741 4435 51741 8089 10370 339488 7020 163732 1387 ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME%R-HSA-210455.4 Astrocytic Glutamate-Glutamine Uptake And Metabolism 6506 6507 2752 81539 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%212165 Epigenetic regulation of gene expression 84661 11091 5928 5929 340252 285676 5931 9070 65251 1108 57504 162967 162963 9112 63924 23517 284306 58508 57678 6601 6603 2180 6602 22880 6605 6604 57693 60481 57459 6319 7700 3065 25942 51003 79813 6908 10891 4221 155054 7329 147686 84962 6940 5440 5441 4331 1022 2071 2966 2965 2068 5434 5435 5437 1020 2968 2967 404672 902 84911 8473 1024 64426 23411 7767 86 2146 55422 60 10793 162655 10025 23309 79862 9968 9969 892 7562 10474 9739 10001 11335 8850 7576 8726 25 3054 11168 29079 7581 5469 9757 53615 197320 5925 8970 8331 4297 2648 8337 128312 9862 8334 6595 8335 6597 25799 2033 6599 8370 6598 55766 10445 8968 7913 8341 8342 8347 8348 51230 94239 8345 3013 7695 8340 8338 255626 6256 6996 3021 653604 3018 3017 85236 3014 8349 90390 474382 84649 1050 54145 54815 2167 11343 6907 9422 3991 8648 79718 8289 23175 84246 9612 9188 10919 29947 51082 8841 55683 9611 55689 729359 123 23054 9443 9869 51535 1107 22976 9442 2874 7343 5166 29128 10514 5346 54934 3066 91661 9440 23468 8202 9533 55596 133522 23272 23512 11176 948 10179 9439 200424 1810 10155 51562 26993 5977 6613 8467 23378 2932 29915 79685 6839 79447 8085 29115 80312 605 259282 8110 2494 25885 9219 79595 57325 147646 9477 84148 51105 54737 22822 22823 10284 125893 64425 7270 147658 79101 80335 10849 6871 26039 57104 2145 284058 8800 10499 55729 6760 221830 8819 8932 55617 7069 1387 91272 121536 9014 9015 9013 90853 57492 9370 26147 84172 54790 2074 81931 340602 79611 26009 9274 9275 9031 23451 1789 90075 1788 1786 7403 3720 8193 112869 113835 143689 51129 51742 10555 5252 23067 30827 4023 9282 100170841 30834 FOXO-MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS, METABOLIC AND NEURONAL GENES%REACTOME DATABASE ID RELEASE 95%9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 3065 25942 4087 4088 4089 56729 2908 10891 5443 2308 4287 6720 3630 3066 5105 847 23460 181 4303 23410 2309 84676 114907 91584 6648 4852 2645 2538 3484 INHIBITION OF TSC COMPLEX FORMATION BY PKB%REACTOME%R-HSA-165181.4 Inhibition of TSC complex formation by PKB 7249 208 7248 GLYCOSPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 95%1660662 Glycosphingolipid metabolism 84002 53947 57704 285362 9514 2760 79642 56624 25870 2717 4074 340075 6610 6609 2524 410 2523 412 414 415 55627 416 8705 8706 9334 22901 9331 64781 153642 7357 2583 2581 57733 55512 347527 427 29906 81849 112937 3074 3073 79411 6483 411 2720 6487 89944 5476 10825 30815 8869 2629 4758 4759 5660 7368 339221 MATURATION OF NUCLEOPROTEIN%REACTOME%R-HSA-9683610.5 Maturation of nucleoprotein 7341 143 2932 2931 56965 7329 83666 84875 79668 54956 54625 REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN METABOLISM%REACTOME DATABASE ID RELEASE 95%9854907 Regulation of MITF-M dependent genes involved in metabolism 23411 10891 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 95%170984 ARMS-mediated activation 673 4803 5906 4914 57498 7529 1398 DEFECTIVE FMO3 CAUSES TMAU%REACTOME DATABASE ID RELEASE 95%5579019 Defective FMO3 causes TMAU 2328 PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 95%5357801 Programmed Cell Death 8772 23604 118 51765 7332 28988 79643 51652 90427 197259 2319 929 3660 79792 8428 3659 6386 91782 9414 3552 57099 2339 708 92421 6709 3553 10059 1991 837 838 353376 841 3837 1828 11035 1832 1830 90249 26060 2934 3002 1613 1612 27243 5533 128866 10134 10015 148022 10971 29082 5317 22900 5534 55075 9500 25978 660 3148 3146 8717 23643 2620 10018 10211 5339 7099 219699 8743 4137 3606 57162 1677 1676 578 51074 115209 1687 4976 4836 572 1029 5599 1499 100506658 999 5580 9861 6233 7316 10213 7534 5062 5706 5707 5708 5709 207 5700 5701 5702 7529 5704 5705 5682 5683 5684 5685 5686 5717 1829 5718 834 5719 839 5071 11047 5713 5714 5690 5691 8473 5692 5693 5694 7311 5695 7532 7314 7531 7533 5687 5688 5689 331 840 842 317 5588 836 54205 56616 5366 637 8626 4001 7431 3024 3009 3008 3007 6093 3006 3005 581 1630 7186 7157 355 79658 356 3836 11140 3320 8737 329 7027 8655 23368 63967 330 7029 1869 10273 7159 5594 5595 208 7161 6774 8795 8797 22985 27113 6304 140735 2810 324 83737 596 598 7082 7979 10000 5747 SENSORY PERCEPTION OF SALTY TASTE%REACTOME%R-HSA-9730628.2 Sensory perception of salty taste 6337 6339 6338 255022 119395 6340 RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME DATABASE ID RELEASE 95%8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 861 865 3559 4773 3558 1493 1378 50943 3458 8784 CONSTITUTIVE SIGNALING BY LIGAND-RESPONSIVE EGFR CANCER VARIANTS%REACTOME%R-HSA-1236382.3 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 11140 3320 1950 5335 2549 867 7311 1956 7314 6233 7316 5295 6464 6654 4893 5290 3265 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME%R-HSA-446219.4 Synthesis of substrates in N-glycan biosythesis 140838 29906 207063 6675 81849 51046 5973 51005 10610 6483 22845 2720 6482 6484 55808 6487 6489 64841 5476 10020 3098 256281 6480 256435 10825 55577 2673 8813 27090 30815 9945 197258 8818 7264 4351 4597 338596 8790 29926 29925 55343 29880 10559 84620 2762 8869 5238 116150 5372 5373 55907 8128 57171 26503 282969 54187 80896 54344 79947 7903 4758 10402 129807 4759 79644 AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME%R-HSA-211163.3 AKT-mediated inactivation of FOXO1A 208 10000 207 2308 NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus 83464 51107 182 4855 102 54567 7534 5663 23385 55851 5664 FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME DATABASE ID RELEASE 95%8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 5706 5707 80028 5708 23194 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 9861 8454 6233 5687 6790 5688 9978 5689 7316 6500 10213 METABOLISM OF INGESTED H2SEO4 AND H2SEO3 INTO H2SE%REACTOME DATABASE ID RELEASE 95%2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se 7296 9061 9060 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%R-HSA-1638091.4 Heparan sulfate heparin (HS-GAG) metabolism 9348 64579 64711 375790 2131 3340 90161 222537 10855 26035 9957 60495 3339 9955 6448 9956 8509 4669 6383 1514 221914 9653 266722 9672 10082 11046 6385 9953 9951 2262 6382 9394 2239 2137 2135 2719 2817 3425 3423 THYROXINE BIOSYNTHESIS%REACTOME%R-HSA-209968.6 Thyroxine biosynthesis 50506 7252 53905 405753 857 51061 7173 1734 1733 389434 90527 6528 1735 1081 TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME DATABASE ID RELEASE 95%8878159 Transcriptional regulation by RUNX3 6696 861 865 7040 1029 595 83439 1026 1499 51176 7004 6932 6934 7003 7005 10413 3516 4609 7157 57154 3845 9759 9861 8850 6233 3280 7316 6714 10213 22938 1490 55534 4193 5706 5707 5708 5709 4088 3683 4089 5700 5701 5702 5704 64750 5705 5682 5683 5684 5685 5686 5717 5718 5719 3676 9794 25937 2648 8463 463 6046 1387 11047 5713 5714 2033 5690 5691 5692 5693 182 5694 7311 7979 5695 7314 10018 84441 5687 5688 5689 10046 4851 2309 864 PECAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 95%210990 PECAM1 interactions 3690 5777 4067 3685 5335 3635 7525 2534 5781 3932 5175 LINIFANIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702998 linifanib-resistant FLT3 mutants 2322 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%R-HSA-397795.6 G-protein beta:gamma signalling 55970 207 9459 54331 59345 2793 2792 2791 2790 5170 998 2788 2782 2787 2786 2785 2784 2783 5330 51764 5331 10681 23236 208 5058 10000 695 146850 5294 23533 94235 387 INTERLEUKIN-12 SIGNALING%REACTOME%R-HSA-9020591.3 Interleukin-12 signaling 3716 3936 654483 3313 5478 6647 5898 6845 6888 4001 5908 7297 4282 5055 3595 3594 3593 3592 1072 27250 302 1265 3586 5721 4478 6950 2939 5306 759 829 998 6627 3458 3181 6175 9987 5034 9049 6648 6775 9446 3185 4507 5062 375 3717 NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME%R-HSA-5654733.3 Negative regulation of FGFR4 signaling 673 2251 8074 867 2249 2247 2246 152831 8823 10253 8569 2264 5781 5515 7311 5516 7314 5518 5594 5595 6233 10818 7316 8817 26281 9965 2254 ASP-3026-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717264.3 ASP-3026-resistant ALK mutants 238 DAG AND IP3 SIGNALING%REACTOME%R-HSA-1489509.4 DAG and IP3 signaling 113 114 115 5335 107 108 109 196883 5566 5567 5568 3710 5153 5573 5575 5576 5581 5577 5582 5613 156 3838 5137 10645 10768 26960 84254 814 808 5580 5136 815 5578 3708 3709 816 817 818 111 112 DISEASES OF MITOCHONDRIAL BETA OXIDATION%REACTOME DATABASE ID RELEASE 95%9759774 Diseases of mitochondrial beta oxidation 4594 166785 ERK MAPK TARGETS%REACTOME%R-HSA-198753.3 ERK MAPK targets 5515 6197 5516 6196 5594 5518 5595 9252 6195 4205 5600 2002 5528 4208 5598 51231 1849 1432 1848 5519 1846 1845 LIPOPHAGY%REACTOME DATABASE ID RELEASE 95%9613354 Lipophagy 51422 3312 5563 5571 10226 5564 5565 123 53632 LAMININ INTERACTIONS%REACTOME%R-HSA-3000157.4 Laminin interactions 3918 3679 284217 3908 3909 3910 3911 3912 3691 3672 22795 80781 3339 3675 3655 3685 4811 3673 3688 3913 3914 3915 10319 BIOTIN TRANSPORT AND METABOLISM%REACTOME%R-HSA-196780.3 Biotin transport and metabolism 8884 31 64087 5096 686 5091 56922 3141 32 5095 51248 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 95%400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 23478 60559 2864 28972 2695 90701 139760 1803 2626 3670 5122 9789 5080 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME%R-HSA-156711.4 Polo-like kinase mediated events 2033 91750 132660 993 4605 7465 286826 891 9088 2305 995 55957 5928 5347 9133 1063 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 95%2299718 Condensation of Prophase Chromosomes 474382 54145 891 983 10051 10592 54892 5347 29781 23310 79648 5925 8970 8331 8337 128312 8334 8335 8370 387893 55766 8968 8341 8342 8347 8290 8348 94239 8345 3013 8340 6418 8338 255626 3021 653604 3018 3017 85236 3014 8349 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME DATABASE ID RELEASE 95%2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 28514 4851 182 6868 3714 102 54567 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH5 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9918438 Defective visual phototransduction due to RDH5 loss of function 5959 6017 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%R-HSA-390471.3 Association of TriC CCT with target proteins during biosynthesis 55294 55135 898 6499 11328 9134 908 10238 10517 6950 7203 26330 10574 8841 84261 10576 26272 7157 22948 63971 26985 26224 83752 26234 54461 10528 10693 6468 8877 10564 10694 2629 26190 10575 26270 6774 22803 REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-8934593.2 Regulation of RUNX1 Expression and Activity 4343 192669 23112 27327 26523 861 865 192670 1021 595 27161 57690 894 896 5371 6714 5781 RHO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9012999 RHO GTPase cycle 57498 2319 9414 708 6709 9146 1828 1832 10134 7204 55075 55160 23365 9181 128272 57580 10211 26230 121512 1894 10451 7410 84904 26084 23370 25791 89846 9826 9828 7409 23229 22899 50649 8997 6453 7984 29 8874 64857 57449 2245 23263 50650 221472 9639 10672 10276 55701 5879 9459 9138 4168 27237 7074 6655 11214 5924 9738 908 10376 8239 60 10254 8027 65124 55200 399693 1080 253959 4722 23616 56667 57636 57630 55219 5825 64283 1362 22852 55227 26092 91544 1124 2697 10409 6811 91452 27289 832 10970 4649 10505 57679 6711 5880 114885 79598 3336 284119 27145 4548 57579 57216 253980 10963 4690 5783 55968 54514 4580 55852 8086 4698 11113 10144 25963 79834 2185 23433 667 79822 9928 6793 5585 5586 3163 54438 5338 7415 157285 91010 9938 23779 8502 54443 9824 5361 752 5364 7535 8503 998 9855 9732 25813 224 6472 11180 11060 8776 1152 94240 29941 85415 11188 10818 84681 6242 8301 11075 120 23380 84317 9748 23141 8440 94134 9528 7126 387 390 81624 391 388 26999 6654 389 23129 399 222584 51566 171177 23256 9322 84144 55704 70 23002 2802 65992 5099 9217 55831 51479 114793 54509 55717 29984 9462 10810 1730 80005 22800 537 93663 26049 9590 57473 5295 7170 3688 5296 9231 7171 123720 80115 158747 5290 57120 8153 63916 84986 9497 50618 71 157769 84612 114822 57381 3954 445582 58480 2631 29843 2886 1795 1794 10726 1793 1729 152273 79180 23074 23197 6714 1445 10817 3932 182 1629 1213 23221 29766 55023 7919 5756 124540 3326 87 55004 8773 50508 7444 6510 2909 9743 57584 392 9341 394 5062 395 1536 10811 397 1535 10458 55843 10979 9815 7879 55845 4688 4689 10298 10652 3998 9235 9710 81839 23092 55971 143872 347902 1829 4810 55619 85360 8936 10424 10787 5881 27 10152 64411 124056 2010 23344 143098 2889 29127 4983 613 857 8987 3930 55789 51347 26050 3071 4162 7112 7037 5058 10163 28964 80728 22865 23191 653361 23592 23075 116984 55114 27035 11135 4952 1969 10006 55914 4001 7431 9475 8452 6434 8654 10250 9886 27316 23013 9352 6093 3183 11329 56254 2873 79869 5930 10574 51138 9318 10576 4646 1627 4296 10928 115557 23048 26030 80243 54874 79658 83478 7454 9754 7456 115703 2040 139818 201176 10788 57514 51133 26286 9901 64333 9644 116985 23268 147179 57480 117289 57522 3895 9912 50855 51306 8826 11140 343578 3320 9411 50619 221178 101059918 124997 58504 257106 1123 23526 5063 4650 153478 57144 644150 393 55240 396 398 84364 5337 29062 148170 51291 3728 144402 8976 85440 90627 8476 56990 81704 23348 89839 57569 23580 10395 10435 92799 10160 9578 25894 57572 23513 10602 128239 56924 200894 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 95%8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 5579 861 865 3958 1387 1437 REGULATION OF PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 95%9861718 Regulation of pyruvate metabolism 57546 55066 3939 79018 54994 10296 1737 4289 25852 2954 80232 10048 54704 5166 7311 7314 1738 6233 5162 5163 7316 5164 5165 23409 64795 4199 4750 64777 8050 5160 5161 DEFECTIVE CYP11B1 CAUSES AH4%REACTOME%R-HSA-5579017.4 Defective CYP11B1 causes AH4 1584 MITOTIC G2-G2 M PHASES%REACTOME%R-HSA-453274.4 Mitotic G2-G2 M phases 10383 10382 91750 993 132660 7846 7465 5566 286826 9088 2305 55957 5928 7277 7157 4605 6790 8945 3320 22974 1871 51343 8655 1063 1869 151648 5577 2033 23332 22919 5048 55835 54820 80028 1781 23194 1778 1017 3326 994 1026 995 9793 5519 5515 5516 5518 9861 6233 9738 84962 9978 7316 9662 7840 7514 5500 11064 22994 22995 10213 7283 10733 80321 4331 203068 114791 55722 1022 1454 5706 1453 5707 5708 55125 9814 85378 5709 11190 115106 22822 79441 95681 10426 5700 5701 27175 1069 891 5702 653784 54801 983 55320 10142 51400 5704 9702 10133 10540 5705 28227 5682 5347 5108 23291 11116 5683 4218 5684 4751 5685 29922 55355 902 5686 63943 55142 3161 22897 27229 5717 51451 5718 54930 4659 5719 5520 5116 79959 90381 79596 80184 93323 79866 11047 728642 51512 23354 5713 22981 5714 440145 5690 8481 5691 10844 5692 80254 5693 121441 5694 55755 7311 984 7979 5695 10806 7532 10121 7314 7531 55559 8636 8454 11258 80097 5687 84131 5688 4957 5689 9133 890 8900 6500 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME DATABASE ID RELEASE 95%76005 Response to elevated platelet cytosolic Ca2+ 51706 2 7076 7078 7873 7114 3671 66005 213 7040 3273 335 3827 1521 6414 6810 139322 308 3700 6814 6813 10487 3309 7123 5340 5341 5345 29106 83706 3959 54676 710 1893 259215 7277 5473 10184 78991 51571 967 9948 6694 5004 334 5919 55664 5874 7018 1191 3699 374354 7273 10447 5175 54863 5005 2316 81 5768 2335 1950 5196 3690 3674 7043 7042 27154 6678 5099 87 5216 5054 808 88 948 5578 7422 7424 7423 2277 2244 2266 7057 7414 5478 6647 7450 2243 7094 226 1072 7044 5582 3082 5265 2621 5579 22915 10490 5267 29789 2153 3481 5627 350 94121 351 197 3479 51368 8407 10257 12 5155 5552 22927 2162 1 51097 23052 2157 9749 3920 928 135228 54495 5660 10916 6403 1675 813 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 95%419408 Lysosphingolipid and LPA receptors 53637 163404 8698 57121 9170 9890 23566 64748 9294 54886 79948 1903 1902 1901 DISEASES OF PROGRAMMED CELL DEATH%REACTOME%R-HSA-9645723.8 Diseases of programmed cell death 474382 2146 54145 1029 5052 4001 993 994 995 7001 5928 7186 7157 5931 356 23512 8772 8726 197259 6648 23649 5422 831 8737 2801 5557 5558 708 84290 823 824 826 1020 841 11035 8851 8970 8331 8337 128312 8334 8335 8370 55766 8968 8717 8341 351 8342 7531 10018 8347 8348 94239 8345 3013 1789 8340 1788 1786 8338 255626 2309 1687 3021 653604 3725 3018 3017 85236 3014 8349 PROCESSING OF SMDT1%REACTOME%R-HSA-8949664.2 Processing of SMDT1 90550 91689 6687 9512 10939 23203 55486 55013 79568 221154 11331 30968 10730 10367 286097 5245 IMATINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674396.2 Imatinib-resistant PDGFR mutants 5156 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME%R-HSA-76042.5 RNA Polymerase II Transcription Initiation And Promoter Clearance 2071 2966 2965 83860 2963 2962 8148 2068 5434 6872 5435 5436 51616 6874 5437 6873 5438 5439 2968 2967 404672 6881 5430 5431 138474 54457 5432 5433 6908 902 6880 6883 2961 2960 6882 6884 2959 2958 129685 2957 6875 6878 6877 6879 5440 5441 4331 1022 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1251932.5 PLCG1 events in ERBB2 signaling 1950 2064 5335 1956 ELASTIC FIBRE FORMATION%REACTOME DATABASE ID RELEASE 95%1566948 Elastic fibre formation 655 3693 5045 3694 7448 7040 3688 8516 650 4052 4054 2199 27302 8076 2192 10516 2006 652 84467 2202 2201 2200 3696 30008 8200 84171 3690 8425 4015 3685 4016 4237 4017 3678 4238 84695 4239 7043 7042 PROTEIN LOCALIZATION%REACTOME DATABASE ID RELEASE 95%9609507 Protein localization 5009 4843 5825 9804 6811 91452 291 293 4580 9512 23203 7416 25813 3329 11001 5264 2671 2395 23600 283927 1610 390916 100272147 8528 516 10651 9218 6901 10531 3416 400916 150274 8266 8540 5827 5828 54363 56942 54927 92609 5824 197257 8310 29928 8799 2053 3417 51142 498 51025 51024 51268 30 8309 6804 10478 819 8443 134266 1891 3155 27230 79145 122970 27235 54543 7323 3421 6233 7322 4358 29090 10245 9409 10005 26519 7485 5189 1384 7316 9381 9868 26515 3162 26517 7917 23480 54677 51287 8604 11264 7321 439 10452 50 51 3313 90639 1537 5195 51608 10063 26521 5190 3295 5191 5192 5193 5194 10469 10901 51179 26520 5621 100188893 80273 219743 373156 100287932 570 54332 1678 401505 84269 215 1431 56993 55825 6449 2010 6844 8504 617 83752 10952 7311 847 131474 6342 7314 351 131118 55670 26063 10965 196743 189 1962 388753 84896 225 10165 10440 54469 506 26061 4714 8239 DEFECTIVE SLC22A18 CAUSES LUNG CANCER (LNCR) AND EMBRYONAL RHABDOMYOSARCOMA 1 (RMSE1)%REACTOME%R-HSA-5619066.4 Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) 5002 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME DATABASE ID RELEASE 95%159740 Gamma-carboxylation of protein precursors 2621 2147 632 2158 2155 8858 5624 5627 2677 2159 HEDGEHOG 'OFF' STATE%REACTOME DATABASE ID RELEASE 95%5610787 Hedgehog 'off' state 113 374654 114 8100 115 80199 51098 55811 107 79809 108 26160 109 196883 6608 11127 57728 23432 5566 27152 5567 57539 5568 54903 5727 2737 2736 9861 6233 9978 2932 7316 2778 1452 10213 8650 51684 8945 2735 5706 5707 5708 5709 83737 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 5573 5575 5576 5577 11047 5713 5714 5690 8481 5691 5692 5693 5694 7311 7979 5695 7314 8454 5687 5688 5689 6500 7289 9742 23322 55081 111 55764 112 79659 THE ROLE OF NEF IN HIV-1 REPLICATION AND DISEASE PATHOGENESIS%REACTOME%R-HSA-164952.3 The role of Nef in HIV-1 replication and disease pathogenesis 163 9844 10053 8907 5879 8905 1175 130340 1173 1174 162 55690 164 3105 940 2534 567 926 3055 3932 51606 1794 920 160 161 5062 375 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1MW LOSS OF FUNCTION%REACTOME%R-HSA-9918436.1 Defective visual phototransduction due to OPN1MW loss of function 2652 BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME%R-HSA-9026766.2 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) 4056 NEF AND SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 95%164944 Nef and signal transduction 5879 2534 3055 3932 1794 9844 5062 SARS-COV-1 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME%R-HSA-9692912.2 SARS-CoV-1 targets PDZ proteins in cell-cell junction 64398 TRANSCRIPTIONAL REGULATION BY TP53%REACTOME%R-HSA-3700989.8 Transcriptional Regulation by TP53 143686 63970 1327 5928 900 51755 1329 905 4850 1340 4848 1337 4849 5931 5933 5934 1339 1351 1350 1349 1347 1346 1345 55215 1108 1121 22974 4869 10769 125965 27166 10971 29117 1386 124446 613227 27154 57459 133383 3065 4436 1029 6872 5300 1017 6874 6873 1026 995 25904 79813 5562 6908 5563 6794 10419 7248 5564 5565 389541 6880 6883 10650 28956 6882 57521 6884 55004 8649 55571 4697 51422 4343 51499 192669 55615 10670 6009 23112 6875 6878 27327 5305 26523 8812 6877 5571 192670 6879 64121 27161 64223 57690 246175 153129 6233 53632 2475 7249 58528 10542 64065 56950 10325 7316 6921 6923 11200 4194 79837 5440 5441 7534 4331 4193 5608 1022 7994 2071 2966 6829 2965 4512 2963 4513 2962 4514 54541 2068 5434 5435 207 5436 1263 5437 9099 1020 5438 5439 5325 2968 7529 5728 2967 404672 5430 5431 138474 5432 5433 902 55367 8851 834 835 839 1432 1460 1459 1457 843 604 7311 7532 5111 7314 7531 84701 7533 8621 5600 5875 5876 10848 317 79109 54205 3486 5366 7832 637 8626 84289 6446 639 10498 5371 6881 581 7862 2177 2176 129685 7157 3276 4292 665 355 7874 341947 1643 5395 6790 25946 9997 80196 79733 5457 5458 23774 253260 8738 7027 8445 91875 51616 898 53615 9540 55240 1616 23368 9134 54457 85456 1027 7029 1869 64769 1820 2033 54971 57060 9337 94241 7159 117584 51230 90809 55835 79370 208 7161 57103 28984 8794 8795 8550 8793 8797 83860 9125 54815 5052 9656 9891 144455 7001 1874 26013 9377 10919 27113 23019 50484 5519 1647 332 5170 133746 1107 387893 58484 5515 3066 83667 5516 5518 9212 9167 10397 147923 5527 2810 112858 3622 2539 26155 2821 9219 7296 27165 8148 2744 57472 891 7295 983 8178 25920 7486 51224 6924 5982 5883 7936 8396 6827 5884 5983 6749 116028 9150 6917 3364 204851 472 1025 51497 7469 672 11198 84126 1387 904 1111 29883 83990 144715 83695 5810 10111 5932 4361 7156 84883 9156 5892 4683 11073 2353 580 10524 641 1763 2877 545 6117 10000 5984 5985 890 6119 8900 3725 6118 80010 28996 ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME%R-HSA-442755.9 Activation of NMDA receptors and postsynaptic events 114 107 5566 5567 5568 5879 5562 5563 5564 5565 5924 8573 5170 55327 51422 22843 27330 320 116443 116444 8536 5571 64130 2892 808 8825 88 57576 2891 2893 2890 9647 3084 5923 1742 53632 1741 1740 2906 1739 2905 815 2904 4900 6714 2903 816 4747 2902 817 818 5573 5575 5576 4893 5577 5613 3838 10645 26960 84254 6197 814 6196 5594 5595 6195 28964 3265 REGULATION OF TP53 ACTIVITY%REACTOME%R-HSA-5633007.5 Regulation of TP53 Activity 8626 84289 6446 639 5371 6881 5928 900 7862 129685 7157 5931 7874 6790 25946 80196 5457 5458 23774 1108 253260 22974 8445 91875 51616 53615 1616 23368 54457 64769 2033 29117 54971 94241 7159 117584 51230 90809 208 7161 8550 27154 57459 133383 83860 3065 54815 1029 6872 5300 9891 6874 1017 6873 26013 79813 5562 6908 5563 6794 10419 5564 10919 5565 6880 6883 6882 5519 6884 5170 133746 51422 1107 55615 6875 6878 387893 5305 6877 5571 3066 5515 6879 64223 5516 5518 9212 6233 53632 2475 56950 5527 7316 112858 11200 4194 79837 3622 26155 9219 4193 5608 7994 8148 207 1263 9099 1020 983 138474 7486 5982 8396 5883 5884 6749 5983 8851 116028 3364 204851 472 672 1432 11198 1460 84126 1111 83990 1459 144715 83695 5810 1457 10111 5932 7311 4361 7314 7156 9156 4683 11073 5600 580 10524 641 1763 545 6117 10000 5984 890 5985 6119 8900 10848 6118 79109 80010 28996 TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME DATABASE ID RELEASE 95%9679504 Translation of Replicase and Assembly of the Replication Transcription Complex 91782 25978 92421 30849 81631 7405 79643 51652 27243 5289 128866 8678 29082 INTESTINAL LIPID ABSORPTION%REACTOME%R-HSA-8963678.3 Intestinal lipid absorption MTB IRON ASSIMILATION BY CHELATION%REACTOME DATABASE ID RELEASE 95%1222449 Mtb iron assimilation by chelation 4057 REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME%R-HSA-8948751.3 Regulation of PTEN stability and activity 80351 80243 9861 81847 6233 8975 23608 5987 4734 2444 7316 8658 10213 5706 5707 5708 5709 207 5700 5701 5702 5728 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 1460 11047 5713 1459 23252 5714 5690 5691 1457 5692 10273 5693 5694 7311 11060 7979 5695 7314 5687 5688 5689 208 10000 331 DEFECTIVE CYP17A1 CAUSES AH5%REACTOME DATABASE ID RELEASE 95%5579028 Defective CYP17A1 causes AH5 1586 TANDUTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702636 tandutinib-resistant FLT3 mutants 2322 ACTIVATION OF RAC1 DOWNSTREAM OF NMDARS%REACTOME%R-HSA-9619229.3 Activation of RAC1 downstream of NMDARs 5879 10645 84254 8536 28964 808 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 95%2514859 Inactivation, recovery and regulation of the phototransduction cascade 2342 2779 10988 23173 388531 2339 79823 9626 2979 2978 2792 5145 2782 5158 5148 808 6010 6295 6011 5578 4836 3000 2986 5588 1259 1258 5957 9397 131890 5475 ACETYLCHOLINE INHIBITS CONTRACTION OF OUTER HAIR CELLS%REACTOME%R-HSA-9667769.2 Acetylcholine inhibits contraction of outer hair cells 55584 3781 57053 3778 3779 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME%R-HSA-5358565.3 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 4292 4436 5111 9156 10714 5424 5395 5425 57804 3978 2956 6117 6119 6118 SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 95%9006927 Signaling by Non-Receptor Tyrosine Kinases 595 1017 9844 5879 5770 63916 6233 2034 3084 1398 1793 3091 5829 7316 116985 2909 1950 2064 867 1956 207 1019 898 10657 27043 10656 1027 2908 9564 1796 55620 6725 6421 202559 5921 4893 7311 9542 9021 10718 7314 145957 685 2069 6774 120892 5753 1839 387 10457 3265 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%R-HSA-2206282.5 MPS IIIB - Sanfilippo syndrome B 4669 MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9816359.2 Maternal to zygotic transition (MZT) 474382 9125 54145 7290 25904 7004 9775 23019 4850 1975 23405 10413 55571 7157 4848 4849 1977 29128 27161 246175 200424 8106 57472 1981 85456 10765 8970 8331 129563 8337 128312 5620 1387 8334 100288687 29883 8335 201516 503835 2033 5619 8370 1974 1973 342900 55766 678 8968 390245 9337 23135 8341 503627 8342 55211 8347 100033411 26986 8348 54766 94239 285051 8345 79670 3013 284355 23318 8340 132243 10361 7403 390748 8338 5927 255626 359787 10605 124512 3021 57379 653604 6732 3018 151871 3017 85236 3014 8349 NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME%R-HSA-112314.10 Neurotransmitter receptors and postsynaptic signal transmission 113 114 115 2774 107 108 55970 109 196883 5566 5567 5568 54331 59345 4646 8573 55327 22843 27330 2782 320 116443 116444 8536 64130 2892 8825 57576 2893 10681 9647 5923 55584 5573 5575 5576 4893 5577 5613 5594 5330 5595 5331 23236 9463 23229 3760 3761 2550 3759 3359 3265 200909 3772 2562 2561 2560 2559 2558 2557 83988 2556 2555 2554 2036 3762 3763 3765 3766 27092 5879 3768 5562 7102 5563 2570 23426 2569 5564 4905 5565 2567 2566 5924 3773 346562 9495 55879 170572 5170 10369 51422 10368 8973 1143 1142 1141 59283 5571 2900 1138 2743 808 1137 88 1136 2742 2891 1135 2890 3084 2741 1742 1134 53632 1741 2901 1740 285242 2906 200959 1739 1146 2905 1145 815 1144 2904 9568 4900 2771 5578 6714 2770 2903 27020 816 89832 4747 9177 2902 8001 817 2899 818 2898 2897 4193 2773 80852 2793 2792 2791 2790 5582 3838 5579 2788 10645 2787 26960 2786 84254 2785 6197 814 6196 2784 2783 6195 51764 28964 94235 160 111 112 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2485179.4 Activation of the phototransduction cascade 2779 9187 2782 5158 6010 5148 6295 1259 2792 1258 5145 DEFECTIVE CYP26C1 CAUSES FFDD4%REACTOME DATABASE ID RELEASE 95%5579004 Defective CYP26C1 causes FFDD4 340665 DEFECTIVE PYROPTOSIS%REACTOME%R-HSA-9710421.5 Defective pyroptosis 23649 474382 5422 2146 54145 5557 5558 5928 8970 8331 8337 128312 8334 8335 8370 55766 8968 5931 8341 8342 8347 8348 23512 94239 8345 3013 1789 8340 1788 1786 8338 255626 1687 3021 8726 653604 3018 3017 85236 3014 8349 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 95%9909396 Circadian clock 10498 406 26224 5465 8945 5469 5499 4297 2033 9572 1386 6256 6604 6097 6096 6095 6907 8648 79718 10135 4208 5054 5501 10891 8204 8841 9611 23054 9861 6233 9978 7316 5500 10213 7321 1454 5706 1453 5707 56938 5708 4209 5936 5709 79365 1628 8553 4862 5700 1374 5701 1408 1407 1020 5702 5187 551 80205 5704 85457 5705 150094 5682 8864 23291 5683 8863 5684 23373 5685 85441 10499 5686 10743 96764 5717 28999 5718 9575 5719 64784 25819 200186 7942 1460 11047 6720 1387 5713 1459 5714 5690 5691 2155 1457 5692 5693 5694 7311 7979 5695 7314 8454 5687 5688 5689 23411 6500 REGULATION OF GAP JUNCTION ACTIVITY%REACTOME DATABASE ID RELEASE 95%191650 Regulation of gap junction activity 7082 2697 ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 95%9603381 Activated NTRK3 signals through PI3K 3667 5295 6714 5290 4916 4908 DISORDERS OF TRANSMEMBRANE TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%5619115 Disorders of transmembrane transporters 553 554 10058 6566 91445 6048 9152 682 335 6557 91319 6559 9843 5244 10956 55788 28234 81031 6569 1836 6584 10568 6578 283652 1080 348995 9883 6396 129401 9688 57122 23225 4927 23165 55746 55706 23636 9631 7175 9972 11097 23279 8086 23511 53371 8480 79023 79902 10762 5903 54716 23443 7415 10999 340024 7355 6505 6507 9056 153201 6520 9197 55315 11254 11136 6519 2646 2645 64241 64240 19 21 9861 6233 6528 6575 7316 10213 8021 3098 5706 9187 5707 5708 5709 5700 5701 5702 551 5704 5705 5682 5683 5684 5685 5686 5717 10479 5718 285195 55343 5719 27248 11047 10559 79139 215 26154 5713 8647 5714 51009 5690 6005 5691 6521 5692 6400 5693 9990 5694 368 7311 6513 7979 5695 60482 7314 6514 26503 116085 5826 11160 8671 5687 6531 5688 6530 142680 5689 123041 1356 6524 6523 10599 246213 5172 55630 1244 5002 56606 10060 4891 30061 6833 3767 10613 1811 552 NFE2L2 REGULATING ER-STRESS ASSOCIATED GENES%REACTOME%R-HSA-9818035.1 NFE2L2 regulating ER-stress associated genes 2033 4780 468 1387 7975 CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME%R-HSA-5620920.6 Cargo trafficking to the periciliary membrane 10013 6608 129880 149371 6753 1262 1260 27241 10576 123016 55763 79738 8729 22948 5310 5311 166379 55212 55770 117177 403 79969 50807 23265 92482 8195 84747 60412 378 84100 54536 2847 6102 8766 6010 582 583 54585 585 27031 192668 1258 9727 10640 11336 4218 6950 7203 10694 10575 56623 5147 200894 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%R-HSA-2142816.3 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 1557 1545 1544 113612 1543 8529 1559 1558 1579 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-1912408.8 Pre-NOTCH Transcription and Translation 474382 54145 861 595 3516 7157 4343 192669 23112 27327 26523 192670 27161 57690 8850 22938 55534 5584 7027 100996717 51548 1991 1999 100996763 1871 388677 7029 1869 8970 8331 9794 2648 8337 128312 1387 8334 8335 2033 8370 55766 8968 8341 8342 84441 8347 8348 94239 8345 3013 8340 10046 4851 8338 4853 255626 4854 4855 3021 653604 3725 3018 3017 85236 3014 8349 REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME%R-HSA-6804758.5 Regulation of TP53 Activity through Acetylation 7994 27154 57459 3065 54815 84289 207 5300 5371 53615 5928 8396 7862 7157 64769 2033 1107 5305 5931 29117 3066 90809 208 10000 79837 3622 23774 1108 9219 5608 SIGNALING BY FGFR2 IIIA TM%REACTOME%R-HSA-8851708.2 Signaling by FGFR2 IIIa TM 2963 2962 5434 5435 5436 2247 5437 5438 2246 5439 2263 22916 5430 5431 4686 5432 5433 5440 5441 TRISTETRAPROLIN (TTP, ZFP36) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 95%450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 51010 167227 51013 54464 3842 11340 7529 118460 9261 23404 54512 22894 55802 5393 56915 23016 7538 GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME%R-HSA-5696399.2 Global Genome Nucleotide Excision Repair (GG-NER) 60 125476 2873 51138 9318 7341 54891 8554 7329 1643 6233 9978 6612 6613 7316 8607 54778 93973 4331 1022 2071 2966 2965 2068 7528 1069 142 10714 5424 2968 8451 5425 2967 5981 404672 57804 8533 29844 3978 2073 2072 5982 64708 56655 902 85015 5983 7515 7334 9557 7336 10987 10980 5426 5427 3980 51426 50813 283899 10038 83444 2067 10920 1642 10445 54107 7311 7507 7508 5111 7314 10401 79913 54617 6117 5984 5985 6119 5886 6118 4798 5887 86 C6 DEAMINATION OF ADENOSINE%REACTOME DATABASE ID RELEASE 95%75102 C6 deamination of adenosine 103 104 DEFECTIVE CHST3 CAUSES SEDCJD%REACTOME%R-HSA-3595172.4 Defective CHST3 causes SEDCJD 63827 1634 633 1464 1462 9469 1463 10675 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH6%REACTOME DATABASE ID RELEASE 95%5632968 Defective Mismatch Repair Associated With MSH6 2956 4436 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%R-HSA-181431.9 Acetylcholine binding and downstream events 8973 1143 1142 1141 1138 55584 1137 1136 1135 1134 1146 1145 1144 89832 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%R-HSA-111453.7 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 5366 572 6774 637 27113 90427 596 10018 598 DEFECTIVE SLC2A10 CAUSES ARTERIAL TORTUOSITY SYNDROME (ATS)%REACTOME DATABASE ID RELEASE 95%5619068 Defective SLC2A10 causes arterial tortuosity syndrome (ATS) 81031 KETONE BODY METABOLISM%REACTOME%R-HSA-74182.6 Ketone body metabolism 622 3158 65985 5019 3155 79611 64064 56898 38 54511 RUNX2 REGULATES BONE DEVELOPMENT%REACTOME DATABASE ID RELEASE 95%8941326 RUNX2 regulates bone development 632 4086 221044 25925 10013 865 4089 3549 4091 4094 10432 5925 8841 25937 2737 23493 10413 2736 9759 5594 5595 23462 121340 23314 3280 1277 367 6714 7525 25 OTC LEADER SEQUENCE VARIANTS CAUSE OTC DEFICIENCY%REACTOME%R-HSA-9956551.1 OTC leader sequence variants cause OTC deficiency 5009 HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME DATABASE ID RELEASE 95%3371497 HSP90 chaperone cycle for SHRs 3305 10963 84516 3320 3301 1781 10728 1780 5241 1778 3326 10540 8655 2908 1783 829 140735 10121 11258 3304 832 2289 51143 3312 10294 367 55860 51164 3337 830 2288 55466 10671 1639 4306 93661 3306 REGULATION OF IFNG SIGNALING%REACTOME%R-HSA-877312.4 Regulation of IFNG signaling 7341 3716 5777 8651 8554 3459 3460 9021 5770 5781 3458 3717 DEFECTIVE B3GAT3 CAUSES JDSSDHD%REACTOME DATABASE ID RELEASE 95%3560801 Defective B3GAT3 causes JDSSDHD 6382 2239 2719 2817 26229 375790 1462 3339 63827 1634 6383 221914 633 9672 1464 10082 6385 1463 10675 2262 TRANSCRIPTIONAL REGULATION BY RUNX2%REACTOME DATABASE ID RELEASE 95%8878166 Transcriptional regulation by RUNX2 632 579 10013 581 6772 650 3280 25 25925 1019 3549 2099 6502 4091 4094 2908 10432 5925 25937 10273 5594 5595 117581 8493 208 3678 9358 221044 59269 861 865 595 11059 1026 10891 8841 2737 23493 10413 2736 57154 9759 133522 9861 23462 6233 23314 121340 9978 367 2932 7316 6714 9464 10213 5706 5707 6662 5708 4086 5709 7291 4089 207 5700 5701 891 5702 983 5704 5705 5682 1749 5683 5684 5685 5686 2101 5717 5718 5719 4488 1750 11047 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 3958 7314 8454 5687 5688 1277 5689 4322 10000 7525 6500 P75NTR SIGNALS VIA NF-KB%REACTOME DATABASE ID RELEASE 95%193639 p75NTR signals via NF-kB 4792 4803 7311 5584 7314 3551 4790 4804 8878 5970 4615 6233 8767 3654 7316 7189 REGORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME DATABASE ID RELEASE 95%9674403 Regorafenib-resistant PDGFR mutants 5156 DNA REPLICATION%REACTOME%R-HSA-69306.9 DNA Replication 3836 23649 5422 5557 5558 10714 5424 898 5425 3837 57804 5981 51343 6502 3978 9134 56655 8970 8331 5426 8337 5427 128312 8334 8335 8370 55766 8968 54107 8341 8342 8347 8348 94239 8345 3013 8340 8338 255626 3021 653604 3018 3017 85236 3014 8349 474382 54145 8317 1017 56652 246243 64785 11232 8318 5428 9837 5442 84296 51659 29935 10926 92667 9941 2237 55388 6742 23633 9861 6233 9978 7316 10213 51529 7321 5706 8881 64682 5707 25906 5708 11065 5709 8697 7324 10393 29945 27338 119504 5700 5701 29882 5702 246184 996 5704 51434 5705 51433 5682 5683 5684 5982 5685 5686 5983 5717 5718 5719 11047 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 5111 7314 7156 4172 8454 4173 4174 5687 4175 5688 4176 4171 5689 990 1763 84515 51053 6117 5000 5984 5001 890 5985 6119 8900 6500 23595 6118 23594 81620 4998 4999 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME%R-HSA-72662.5 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 8894 8662 1965 8663 8661 8666 1975 8667 8664 1968 8665 27335 3646 51386 7458 1978 8668 1977 8669 10480 1964 6233 1981 6230 6232 6210 6231 6234 6235 6191 2197 6193 6192 6194 51065 140032 6205 6227 6204 6207 6229 6206 1974 6228 1973 6209 6208 6188 6187 6223 6201 6189 26986 6222 6203 6224 6202 6218 6217 3921 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 95%69190 DNA strand elongation 23649 5422 5557 5558 10714 64785 8318 5424 9837 5425 5981 57804 84296 3978 51659 5982 2237 5983 5111 4172 4173 4174 4175 4176 4171 84515 1763 6117 5984 5985 6119 6118 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 95%399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 9855 5362 10371 2242 23396 6237 7094 55558 27289 5879 8829 91584 2534 5361 ABNORMAL CONVERSION OF 2-OXOGLUTARATE TO 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 95%2978092 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate 3417 DEFECTIVE SLC4A1 CAUSES HEREDITARY SPHEROCYTOSIS TYPE 4 (HSP4), DISTAL RENAL TUBULAR ACIDOSIS (DRTA) AND DRTA WITH HEMOLYTIC ANEMIA (DRTA-HA)%REACTOME DATABASE ID RELEASE 95%5619050 Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) 6521 KERATINIZATION%REACTOME DATABASE ID RELEASE 95%6805567 Keratinization 5266 823 826 1828 1832 1830 5317 728279 3880 404203 3881 286887 3882 353323 64065 337879 100288323 83902 54474 337882 337880 81850 81851 3872 11187 3875 643812 140807 643394 3890 3891 3892 353332 353333 121391 83901 83900 2312 3883 3884 3885 3886 3887 3888 3889 728299 162605 337979 337978 337977 337976 1829 337975 448835 100132386 81870 81871 1475 81872 140258 196374 8688 8689 8687 337969 337967 337966 337974 337973 337972 254910 337971 337970 144501 390792 387264 337959 112802 337963 6707 337960 353132 353131 6700 6701 6704 6703 6706 6705 728224 100505753 353134 23254 353133 5045 353135 5046 353137 353139 26085 126638 440051 353141 440050 149018 353140 353143 353142 1825 1824 1823 728255 353145 353144 1041 23581 2125 100507608 11005 147409 9333 5652 387273 51350 192666 254950 387266 387267 340654 728318 353288 25984 440021 125115 643414 100505724 643418 43847 43849 7051 199834 388818 7062 83899 83895 83897 83896 100533177 9119 6768 11202 5318 147183 338785 440023 284827 653240 84616 100131902 85291 85290 85293 4014 26239 84648 386684 386683 386685 85294 3713 85280 319101 374454 63036 386680 386682 386681 386677 3848 3849 386679 386678 386672 3728 386675 8502 57830 386674 342574 85289 3846 85285 6698 3860 3858 3859 3850 142910 3851 3852 3853 3854 3855 3856 3857 5493 25818 439915 100132476 3861 6699 643803 3866 3868 FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME DATABASE ID RELEASE 95%5661270 Formation of xylulose-5-phosphate 10327 51084 9942 6652 51181 IKBKB DEFICIENCY CAUSES SCID%REACTOME DATABASE ID RELEASE 95%5602636 IKBKB deficiency causes SCID 8517 3551 1147 COHESIN LOADING ONTO CHROMATIN%REACTOME DATABASE ID RELEASE 95%2470946 Cohesin Loading onto Chromatin 10735 23063 23383 5885 10274 25836 8243 9126 23244 23047 RMTS METHYLATE HISTONE ARGININES%REACTOME%R-HSA-3214858.4 RMTs methylate histone arginines 474382 11091 595 1019 10498 8289 10419 55193 8331 8337 8334 6595 8335 6597 6599 8370 57492 6598 55766 3276 8968 5931 317772 6187 221613 85235 94239 3013 1788 92815 6601 51412 8338 6603 6602 8969 6605 196528 653604 6604 10196 3014 54496 55170 79084 3717 55352 86 SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME%R-HSA-1855191.3 Synthesis of IPs in the nucleus 253430 64768 51447 9807 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%R-HSA-1660516.9 Synthesis of PIPs at the early endosome membrane 5286 8898 8821 9896 55361 9110 22876 30849 200576 54893 55300 54545 55697 3631 4534 5289 PTK6 DOWN-REGULATION%REACTOME%R-HSA-8849472.2 PTK6 Down-Regulation 5753 6725 5770 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%R-HSA-114508.4 Effects of PIP2 hydrolysis 11343 10235 10125 5583 9162 8527 26090 8525 3710 8526 57406 221955 160851 1609 747 5581 1608 1607 1606 139189 7222 7225 5580 3708 57113 3709 5588 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 95%76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 5434 5435 5437 6908 51082 84265 55703 112495 11128 51728 9330 27297 661 9533 2976 10623 2975 2972 171568 55814 9328 9329 55718 10622 10621 5440 5441 CARNITINE SHUTTLE%REACTOME DATABASE ID RELEASE 95%200425 Carnitine shuttle 5467 51422 6584 58526 5563 6256 1376 788 1375 5565 1374 7069 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%R-HSA-416482.7 G alpha (12 13) signalling events 29 8874 64857 57449 389337 55970 445328 2245 23263 9475 50650 146 221472 147 148 9639 10672 10276 55701 6093 9459 54331 9138 4168 27237 7074 59345 6655 11214 5924 2782 6915 10681 695 2768 2793 2792 2791 2790 5364 7204 2788 55160 2787 23365 2786 9181 128272 2785 57580 2784 2783 26230 51764 121512 1894 10451 7410 84904 100271715 26084 23370 25791 89846 9826 54848 9828 94235 7409 387 23229 22899 388 50649 6654 389 8997 6453 7984 IKBA VARIANT LEADS TO EDA-ID%REACTOME%R-HSA-5603029.4 IkBA variant leads to EDA-ID 8517 4792 3551 4790 4791 5970 1147 SYNTHESIS OF PI%REACTOME%R-HSA-1483226.5 Synthesis of PI 9600 1040 57605 83394 10423 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME%R-HSA-390247.6 Beta-oxidation of very long chain fatty acids 10005 122970 3295 26063 11001 30 215 1962 STAT3 NUCLEAR EVENTS DOWNSTREAM OF ALK SIGNALING%REACTOME DATABASE ID RELEASE 95%9701898 STAT3 nuclear events downstream of ALK signaling 3561 3091 1786 2033 3065 25942 6774 3066 8841 639 29126 SIGNALING BY PDGFR IN DISEASE%REACTOME%R-HSA-9671555.4 Signaling by PDGFR in disease 23189 2120 51411 6801 2803 81608 6774 57599 5295 5296 6772 3791 5156 6654 4893 5290 5291 3265 SIGNALLING TO ERK5%REACTOME%R-HSA-198765.3 Signalling to ERK5 5607 5598 NRCAM INTERACTIONS%REACTOME%R-HSA-447038.2 NrCAM interactions 1739 286 4897 6900 8828 1742 1741 SIGNALING BY RETINOIC ACID%REACTOME DATABASE ID RELEASE 95%5362517 Signaling by Retinoic Acid 5915 5914 5467 5916 1737 6257 112724 10170 9249 8854 64577 1382 10901 1381 57665 216 8608 51109 8644 5959 157506 220 124 126 1592 127 195814 340665 56603 5166 1738 5162 5163 6256 5164 5165 8050 5160 6258 2171 5161 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME DATABASE ID RELEASE 95%2426168 Activation of gene expression by SREBF (SREBP) 5469 6319 10498 6907 80205 8648 79718 4597 85441 10499 96764 2224 1387 2222 6667 23054 3157 1595 79071 6721 1717 2194 10654 6309 9453 4047 4520 3422 57678 4598 6713 7108 4800 4801 4802 5465 31 6256 6604 32 MRNA CAPPING%REACTOME DATABASE ID RELEASE 95%72086 mRNA Capping 2071 2966 6829 2965 2963 2962 2068 5434 5435 5436 5437 5438 5439 2968 2967 22916 404672 5430 4686 5431 5432 5433 902 5440 8732 5441 4331 8731 1022 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 95%2173788 Downregulation of TGF-beta receptor signaling 7046 4087 7048 4088 7040 9110 5499 64750 4092 51377 23645 9958 5501 10273 7311 57154 7314 25805 6233 56937 11171 7316 7514 5500 23327 GLYCOSPHINGOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 95%9840310 Glycosphingolipid catabolism 57704 285362 2760 79642 10825 56624 25870 2717 4074 340075 6610 6609 410 412 414 415 55627 416 22901 153642 2581 57733 55512 347527 427 112937 3074 2629 3073 4758 79411 411 4759 2720 89944 5660 5476 339221 SIGNALING BY NOTCH3%REACTOME%R-HSA-9012852.3 Signaling by NOTCH3 4904 83464 51107 1950 1956 3714 6772 9794 2648 23493 1387 3516 2033 28514 182 7311 11060 7314 84441 23462 8850 6233 3280 5087 9148 10046 9787 54492 171558 4851 23286 7316 142678 4854 26508 10460 388585 57534 102 54567 5663 22938 23129 23385 2173 55851 5664 55534 POTENTIAL THERAPEUTICS FOR SARS%REACTOME%R-HSA-9679191.5 Potential therapeutics for SARS 478 163 3615 3614 57459 5045 29760 51185 10728 3065 1312 53822 3459 973 3460 23186 54815 53826 974 3454 53828 9475 23028 10280 8452 3326 5133 23476 59272 25855 10800 5926 5928 480 10362 51317 481 6093 1175 1173 482 483 486 3688 1107 29110 54106 5931 3066 81030 2280 9978 695 79685 9817 203068 1108 3717 9219 1901 3716 57504 2342 4690 3320 9112 8737 5348 5349 2339 10284 7297 53615 2908 8819 3676 4780 6850 5978 3570 64426 51742 7409 2288 51284 3718 476 3554 6654 5336 160 161 30011 477 6773 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 95%400685 Sema4D in semaphorin signaling 4233 2064 23365 9475 6237 10398 27289 5879 6093 4628 79784 4629 10507 9826 3984 3985 103910 2909 387 4637 4627 388 389 5364 TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME DATABASE ID RELEASE 95%8986944 Transcriptional Regulation by MECP2 4233 3065 25942 6446 5566 6907 5775 79718 4336 5816 6515 4208 9612 5770 8841 9611 4343 54487 2874 192669 23112 27327 7222 26523 2572 3066 192670 2571 27161 808 57690 9212 2290 2891 3654 2289 4986 4988 815 2904 2903 816 817 818 5468 114787 6657 5728 3064 54715 28514 1392 2593 814 627 3930 6750 28996 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 95%983169 Class I MHC mediated antigen processing & presentation 6810 6279 3309 154881 7320 7325 6477 131405 22872 221687 79654 51088 9616 90678 7318 7317 56658 6280 7319 7097 10533 7096 22888 3093 9870 9871 64167 9632 7335 150726 10425 7332 64718 10427 118424 23295 55336 7327 7326 197131 929 9867 7328 8945 10422 54926 8673 65264 9520 114609 10193 10075 93611 127247 401036 79791 29927 55585 57520 89910 811 51665 7337 51666 26091 55905 2209 63893 22863 7334 142686 57531 7336 142685 55236 51676 5720 142689 223082 91694 10293 9666 6271 51320 80204 10616 57542 3146 51444 11146 23643 135892 55008 9554 6047 7099 6049 23376 23014 57674 143279 25793 84231 11275 50489 9320 55819 64410 90025 222235 84937 140691 51465 54850 140456 140458 90933 140459 80028 2923 23194 8651 90135 25897 9690 146330 3551 140460 140461 4615 3107 140462 3106 255488 114088 54620 23352 868 8916 115290 7704 55958 8139 390594 821 127544 55284 84961 27246 997 8924 122769 8925 64320 9354 3134 3133 81559 55175 84708 7174 6478 27252 55176 8453 51130 9861 7323 642 6233 7322 51132 26046 9902 9903 9978 6890 9246 4591 25847 6892 8773 7316 6921 6891 695 6923 158506 92369 54778 55182 126433 10213 7428 23480 26259 64219 8678 23304 9341 7064 201456 144699 5706 3135 5707 899 1536 5708 84861 63891 92912 5709 10477 1535 4360 5696 26268 55070 5700 90293 5701 84727 4688 92591 5702 4689 26263 10802 1520 5704 26267 5705 64750 10484 5682 53339 5683 10489 5684 285231 5685 89890 5721 5686 4012 9820 5717 26235 5718 26118 5719 79176 26232 55521 5071 5698 11047 5699 84085 5713 26272 4008 5714 10333 5690 51725 89122 5691 9039 5692 26249 5693 25831 5694 8065 10952 84078 7311 5695 55658 26234 140739 7314 51619 9040 148581 79876 6468 5687 79754 5688 84541 9730 5689 154214 51191 26190 151636 80176 51752 26270 9604 136371 10324 653361 23327 55294 8452 10517 5930 3105 84261 567 22954 57630 26224 6737 54461 23608 6396 4734 80196 9817 200845 51343 6502 991 8517 10273 30849 3685 84676 5289 1147 3693 11059 29116 57154 948 114907 51529 7321 8881 2244 64682 2266 11065 8697 7324 10393 29945 27338 83737 29882 2243 246184 996 51434 51433 23291 1514 1515 7979 9021 8454 51128 142678 6500 DEFECTIVE SLC35C1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2C (CDG2C)%REACTOME DATABASE ID RELEASE 95%5619078 Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) 55343 INFECTION WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME DATABASE ID RELEASE 95%9635486 Infection with Mycobacterium tuberculosis 1511 5230 4360 7879 9146 2023 4057 11151 3837 26276 5868 4843 6421 567 2931 51606 7311 7314 5594 7097 5595 6233 57674 5987 7316 80824 3836 INHIBITION OF SIGNALING BY OVEREXPRESSED EGFR%REACTOME%R-HSA-5638303.3 Inhibition of Signaling by Overexpressed EGFR 255324 2069 1950 1956 374 1839 7039 685 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%R-HSA-1839122.3 Signaling by activated point mutants of FGFR1 2251 8074 2249 26281 2260 2247 2246 2254 DEFECTIVE HPRT1 DISRUPTS GUANINE AND HYPOXANTHINE SALVAGE%REACTOME%R-HSA-9734281.2 Defective HPRT1 disrupts guanine and hypoxanthine salvage 3251 LATE SARS-COV-2 INFECTION EVENTS%REACTOME%R-HSA-9772573.4 Late SARS-CoV-2 Infection Events 7841 29801 5045 25921 253832 51201 55741 1650 11320 51125 4247 51304 100128731 4249 59272 6185 338440 7991 4124 4245 6184 25834 23193 58505 201595 2530 79844 821 11253 5589 51114 746 1603 3703 7341 3276 143 55107 2931 7329 56965 83666 84875 79668 54956 54625 6233 2932 7316 10610 1452 6483 55129 50636 6482 6484 6487 196527 6480 57719 256435 27090 121601 7311 7314 63982 203859 6732 2589 7113 6733 57101 84061 11282 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME%R-HSA-419812.5 Calcitonin-like ligand receptors 799 79924 3375 10266 10268 10267 10203 133 796 797 DEFECTIVE CD320 CAUSES MMATC%REACTOME DATABASE ID RELEASE 95%3359485 Defective CD320 causes MMATC 51293 6948 LATE PHASE OF HIV LIFE CYCLE%REACTOME%R-HSA-162599.4 Late Phase of HIV Life Cycle 5045 55048 89853 1104 51534 9525 137492 6881 27183 51271 51160 155382 93343 7251 79720 5902 51510 905 129685 348995 9883 6396 129401 9688 79643 57122 51652 23225 4927 23165 9397 55746 55706 23636 9631 91782 7175 9972 11097 23279 8086 92421 23511 53371 51616 8480 79023 79902 10762 5903 54457 27243 128866 2961 2960 10015 2959 2958 2957 29082 25978 4836 83860 6872 6874 6873 6908 5905 6880 6883 6882 6884 6875 6878 8812 6877 6879 5901 6233 7316 6921 6923 7514 5440 8732 5441 4331 8021 8731 1022 2071 2966 6829 2965 2963 5478 8148 2962 2068 5434 5435 5436 5437 5438 5439 2968 2967 8178 22916 404672 5430 25920 4686 5431 138474 5432 51224 5433 6924 7936 902 6827 6749 9150 6917 1025 51497 7469 11198 904 7311 7314 23327 DEFECTIVE ALG8 CAUSES CDG-1H%REACTOME DATABASE ID RELEASE 95%4724325 Defective ALG8 causes CDG-1h 79053 DEFECTIVE FACTOR VIII CAUSES HEMOPHILIA A%REACTOME DATABASE ID RELEASE 95%9662001 Defective factor VIII causes hemophilia A 2147 2158 2157 8459 7450 8460 2159 NOSIP MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 95%203754 NOSIP mediated eNOS trafficking 4846 51070 SCAVENGING BY CLASS A RECEPTORS%REACTOME%R-HSA-3000480.2 Scavenging by Class A Receptors 1282 1281 7184 117156 2512 348 81035 78989 335 5648 338 1278 1277 811 4481 286133 8685 2495 1284 INTEGRATION OF PROVIRUS%REACTOME DATABASE ID RELEASE 95%162592 Integration of provirus 5478 2547 3836 7520 3981 3159 7518 11168 8815 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%R-HSA-198323.6 AKT phosphorylates targets in the cytosol 572 2931 207 1026 84335 23608 7249 208 2932 1027 10000 842 1147 4193 HDACS DEACETYLATE HISTONES%REACTOME DATABASE ID RELEASE 95%3214815 HDACs deacetylate histones 57459 3065 23186 54815 23028 6907 25855 5926 5928 10362 79718 51317 9612 8841 9611 1107 2874 5931 3066 221613 92815 8969 55869 79685 440689 1108 9219 57504 9112 83933 10284 53615 8970 8819 8331 8337 128312 8334 8335 5978 8370 8968 317772 8341 8342 8347 85235 8348 8345 3013 8340 64426 8338 255626 51742 653604 3018 3017 85236 8349 SIGNALING BY ERBB2 TMD JMD MUTANTS%REACTOME%R-HSA-9665686.3 Signaling by ERBB2 TMD JMD mutants 11140 3320 2064 1950 5335 55914 1956 9542 10718 145957 3084 685 2069 1839 6464 6654 4893 3265 REGULATION OF PD-L1(CD274) POST-TRANSLATIONAL MODIFICATION%REACTOME DATABASE ID RELEASE 95%9909615 Regulation of PD-L1(CD274) Post-translational modification 91445 6048 1650 595 91319 8452 5133 100128731 10956 6185 7991 6184 5562 5563 58505 201595 5564 5565 746 1603 3703 51422 5571 9861 6233 8405 10331 53632 80380 9978 2932 7316 10213 8945 29126 3716 5706 5707 5708 5709 1019 5700 5701 5702 5704 5705 5682 5683 5684 4751 5685 5686 7415 5717 5718 5719 10987 1460 27248 11047 79139 5713 1459 5714 51009 5690 5691 1457 5692 6400 5693 5694 7311 7532 7979 5695 7314 8454 11160 5687 5688 5689 142678 6500 10613 84061 DEFECTIVE CHST14 CAUSES EDS, MUSCULOCONTRACTURAL TYPE%REACTOME DATABASE ID RELEASE 95%3595174 Defective CHST14 causes EDS, musculocontractural type 63827 1634 633 1464 1462 1463 10675 113189 PELO:HBS1L AND ABCE1 DISSOCIATE A RIBOSOME ON A NON-STOP MRNA%REACTOME%R-HSA-9954714.2 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 6233 6152 6155 6154 6157 9349 6156 6159 6158 23521 51121 6175 11224 6164 200916 6166 6122 6165 6124 6168 6123 6167 6169 6125 116832 25873 6160 6161 140801 4736 53918 6130 6133 9045 6230 6232 6132 6210 6176 6231 6135 6234 6134 6235 6137 6191 6136 2197 6059 6193 6171 6192 6170 6194 6173 51065 6128 140032 6129 6205 6142 6227 6141 6204 6144 6207 6143 6229 6146 6206 6147 6228 6181 6139 6209 6138 6208 6188 7311 6187 6223 6201 6189 6222 6203 6224 6202 6218 6217 3921 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1SW LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9918443 Defective visual phototransduction due to OPN1SW loss of function 611 E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME%R-HSA-8866654.5 E3 ubiquitin ligases ubiquitinate target proteins 5828 56254 3105 7320 10670 7319 7323 6233 7322 7332 7316 118424 7321 7324 5195 5192 5193 5194 7415 7334 8970 7336 79139 92305 7311 6596 23168 8341 5111 7314 9781 8342 56852 8347 79577 8348 51322 5591 8345 80349 123169 8340 51255 9646 257218 55829 255626 9810 220441 54623 8915 3018 3017 85236 PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF THE CRY:PER:KINASE COMPLEX%REACTOME DATABASE ID RELEASE 95%9931530 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex 1459 1454 1453 1457 1408 1020 1407 5187 5499 8864 8863 5500 5501 1460 HHAT G278V DOESN'T PALMITOYLATE HH-NP%REACTOME DATABASE ID RELEASE 95%5658034 HHAT G278V doesn't palmitoylate Hh-Np 55733 6469 50846 3549 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME%R-HSA-168142.3 Toll Like Receptor 10 (TLR10) Cascade 51295 51135 4214 7100 9684 4793 28512 57161 79671 3551 177 4615 121457 81793 246330 5599 28511 3656 257397 6885 23118 1326 5609 466 80216 6416 4208 5601 7867 5602 5606 5519 7186 7189 79155 7157 5515 5516 5518 6233 8767 9261 3654 7335 10454 7316 5528 4791 64127 8945 5608 5970 9097 841 23291 7334 11274 1432 8517 4792 10392 7311 3146 6197 7314 6196 351 5594 4790 5595 9252 8454 6195 1386 4205 2353 5600 57162 2002 5598 6500 5604 3725 51231 1849 84166 1147 1848 6285 1846 6288 1845 92610 6283 IRAK4 DEFICIENCY (TLR5)%REACTOME DATABASE ID RELEASE 95%5603037 IRAK4 deficiency (TLR5) 51135 7100 4615 81793 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 95%418885 DCC mediated attractive signaling 4690 998 7204 1793 5879 5747 6714 22885 84448 8976 1630 3983 9423 DEFECTIVE PNP DISRUPTS PHOSPHOROLYSIS OF (DEOXY)GUANOSINE AND (DEOXY)INOSINE%REACTOME DATABASE ID RELEASE 95%9735763 Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine 4860 RSV-HOST INTERACTIONS%REACTOME%R-HSA-9833110.2 RSV-host interactions 90390 7706 375790 3454 51003 3339 84246 10025 6383 221914 9968 9969 9672 10082 6385 4131 3442 9443 3441 9441 892 2262 25820 3661 6382 3440 9442 54797 2239 5610 10332 7098 55090 2719 3452 2817 3451 9440 80306 7097 3449 3448 51586 10001 3447 6233 4939 3446 9439 3445 57506 23097 9978 3444 3443 9246 6837 219541 23389 7316 3456 6921 55588 6923 9636 9412 1524 400569 929 30835 8678 29079 81857 3716 9477 5469 112950 7297 64135 10134 1387 9862 10333 2033 1024 8065 7311 23586 23643 8341 7314 7099 51191 51284 9282 6773 REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-HSA-975574.2 Reactions specific to the hybrid N-glycan synthesis pathway 4248 TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME%R-HSA-8869496.3 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation 3329 7020 4869 4605 4839 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA2 RAD51 RAD51C BINDING FUNCTION%REACTOME%R-HSA-9704646.4 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2 RAD51 RAD51C binding function 7486 116028 472 10635 672 675 83990 7516 10111 5932 7979 4361 7156 5890 9156 5892 4683 580 10524 641 1763 79728 5888 80010 5889 EUKARYOTIC TRANSLATION TERMINATION%REACTOME%R-HSA-72764.6 Eukaryotic Translation Termination 6233 6152 51504 6155 6154 6157 9349 6156 6159 6158 23521 51121 6175 11224 6164 200916 2107 6166 29104 6122 6165 327 6124 23708 6168 2935 6123 6167 6169 6125 116832 25873 6160 6161 140801 4736 6130 6133 9045 6230 6232 6132 6210 6176 6231 6135 6234 6134 6235 6137 6191 6136 2197 6193 6171 6192 6170 6194 6173 51065 6128 140032 6129 6205 6142 6227 6141 6204 6144 6207 6143 6229 6146 6206 6147 6228 6181 6139 6209 6138 6208 6188 7311 6187 6223 6201 6189 6222 6203 6224 6202 6218 6217 3921 FORMATION OF HIV ELONGATION COMPLEX IN THE ABSENCE OF HIV TAT%REACTOME%R-HSA-167152.5 Formation of HIV elongation complex in the absence of HIV Tat 2071 2966 6829 2965 2963 2962 2068 5434 5435 5436 5437 5438 5439 2968 8178 2967 22916 404672 25920 5430 4686 5431 51224 5432 6924 5433 7936 902 6827 6749 9150 6917 905 1025 51497 7469 11198 904 8812 6921 6923 5440 5441 4331 1022 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%R-HSA-174403.7 Glutathione synthesis and recycling 2678 124975 79094 2687 79017 2730 2686 494143 55748 26873 2729 2937 LXRS REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX%REACTOME DATABASE ID RELEASE 95%9029569 LXRs regulate gene expression linked to cholesterol transport and efflux 6257 23028 9682 6907 80820 8648 79718 9619 64241 64240 7376 9612 10062 8841 9611 19 1071 221656 341 344 4343 2033 2874 192669 23112 346 27327 347 348 26523 192670 10123 27161 55818 57690 6256 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME DATABASE ID RELEASE 95%975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 10921 4116 22794 9939 6152 6155 6154 6157 9349 6156 6159 6158 23521 51121 11224 6164 65109 200916 6166 6122 6165 6124 6168 6123 6167 6169 6125 116832 25873 6160 6161 140801 4736 6130 6133 9045 6230 6232 6132 6210 6176 6231 6135 6234 6134 6235 6137 6191 6136 2197 6193 6171 6192 6170 6194 6173 6128 51065 6129 140032 6142 6205 6227 6141 6144 6204 6143 6207 6229 6146 6147 6206 6228 6181 6139 6138 6209 6208 6188 6187 6223 6201 6189 6222 6203 6224 6202 6218 6217 3921 9775 55110 5515 5518 6233 55802 6175 2107 23708 2935 1981 23049 23293 22916 9887 55181 4686 26019 23381 55629 5976 65110 56006 5520 7311 26986 PHYSIOLOGICAL FACTORS%REACTOME DATABASE ID RELEASE 95%5578768 Physiological factors 6910 1482 8850 2626 4878 4880 4881 204851 4882 25937 4311 1066 28996 10699 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 95%69278 Cell Cycle, Mitotic 7298 200014 260334 7083 4926 26003 27436 5928 5933 5934 4605 79643 51652 91782 22974 92421 3837 5981 56655 27243 128866 5426 5427 29082 25978 54107 80028 23194 995 29935 10926 2237 55388 7341 7329 9738 84962 9978 4067 4331 1022 902 113457 7280 1460 1459 5579 1457 7532 5111 7531 10376 80086 51807 10381 10383 10382 112714 91750 993 132660 7846 7465 84790 286826 9088 2305 55957 10051 10592 84617 54892 29781 23310 79648 347733 7277 7278 7157 79861 81027 6241 348995 9883 6396 129401 9688 57122 23225 25 4927 23165 55746 55706 23636 9631 7175 9972 11097 23279 8086 23511 53371 8480 79023 79902 10762 8815 5903 54908 6232 8655 25909 8379 9183 1063 1062 9184 1060 991 151648 55166 1058 79019 151246 9735 23332 79003 5594 55055 81565 22919 348235 5048 23421 220134 55835 57082 57405 51143 208 23141 147841 4085 64105 401541 10403 54820 80776 701 54821 378708 1781 23122 1780 79172 1778 81930 55920 84643 1876 3796 1875 1874 9793 91687 57551 79682 5905 1783 5501 83540 80152 2491 5519 332 55143 699 11243 387893 3619 140735 5515 11004 5516 5518 9212 25936 11130 64946 79980 10726 5525 5526 55839 5527 5528 5500 5529 51529 7321 3717 8881 64682 25906 11065 8697 7324 10393 29945 27338 119504 29882 891 246184 983 55320 996 51400 51434 10133 51433 5347 28227 23291 5982 4218 55355 63943 5983 3161 51451 4659 5520 90381 79596 79866 51512 7979 4172 8454 4173 4174 4175 4176 4171 990 1763 84515 51053 5000 6117 5984 5001 5985 890 8900 6119 6500 23595 6118 23594 81620 4998 4999 6249 5566 8945 23649 5422 2801 5557 5558 5577 5753 3065 1029 595 1017 3326 994 1026 64785 8318 9837 84296 51659 4609 5901 9861 6233 7316 9662 7840 7514 5578 11064 22994 22995 10213 7283 10733 80321 203068 114791 8021 55722 1454 5706 1453 5707 5708 55125 9814 5709 85378 11190 115106 79441 207 95681 10426 5700 5701 27175 1069 3842 5702 653784 54801 10142 5704 9702 10540 5705 5682 5108 11116 5683 4751 5684 5685 29922 55142 5686 22897 5717 27229 5718 54930 5719 5116 79959 80184 93323 11047 728642 1030 23354 5713 22981 5714 440145 5690 8481 10844 5691 2010 5692 80254 5693 121441 5694 55755 984 7311 5695 10806 10121 7314 55559 8636 11258 80097 3930 5687 84131 5688 4957 5689 6418 9133 140609 91754 10783 23592 4001 1104 27183 6790 3320 7027 1021 1019 894 896 10714 1871 5424 898 5425 1870 57804 51343 6502 3978 9134 1028 1027 4149 7029 1869 5925 8970 8331 25836 8337 8243 128312 9126 8334 23244 23047 8335 9493 10735 2033 8370 23063 23383 5885 55766 8968 10274 10112 8341 8342 8347 8348 8290 94239 8345 3013 8340 8338 255626 3021 653604 3018 3017 9663 85236 3014 8349 474382 54145 8317 64900 23175 2932 22822 91768 10776 64151 81876 5861 5862 1032 1031 22933 1163 255919 84930 157570 2029 55844 64689 55732 113130 9918 114799 9700 6683 8615 10000 347688 7443 8556 8548 23397 9798 1719 7153 221496 26271 1859 9232 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 95%176814 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins 9861 6233 7316 10213 51529 7321 5706 8881 64682 5707 25906 5708 11065 8697 5709 7324 10393 29945 27338 119504 5700 5701 29882 891 5702 246184 983 996 5704 51434 5705 51433 5347 5682 5683 5684 4751 5685 5686 5717 9184 5718 5719 991 11047 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 5687 5688 5689 4085 890 8900 9232 701 BIOFILM FORMATION%REACTOME%R-HSA-9931953.1 Biofilm formation 11045 4072 METABOLISM OF LIPIDS%REACTOME DATABASE ID RELEASE 95%556833 Metabolism of lipids 84002 53947 57704 285362 9514 2760 79642 56624 25870 1583 2717 1582 4074 1581 340075 1580 6610 5244 22874 6609 81846 2524 126969 28234 410 3638 2523 201164 412 55326 414 1576 415 6584 79777 55627 1455 416 80765 8705 54477 8706 56894 9334 1573 22901 56895 9331 340485 64781 3636 153642 1593 7357 6916 2583 1589 2581 55331 57733 1588 55512 79887 347527 1103 427 1585 79888 5321 1109 64174 1120 125981 10998 27063 4706 147323 83930 114971 55224 5833 1119 5730 204219 100137049 80777 149998 171546 284541 10400 706 158584 5740 2232 126410 1558 1579 2230 123264 1557 84803 345275 1545 10858 1149 1544 57664 128486 113612 6822 161247 1543 6718 8529 29923 5742 63924 1559 5743 133121 284486 4899 5867 6715 6716 66036 3837 137964 5868 22937 5641 114884 80339 80221 10715 8904 50814 22949 388121 114876 81537 114879 145482 81544 114880 441282 114881 114882 114883 866 660 23683 2274 25865 23446 57678 873 51365 253558 26230 64064 2166 56898 3248 254531 38 54511 55856 622 55613 142827 3158 166929 65985 284161 5019 6770 5322 5444 51141 6604 80821 55500 84188 5319 25979 4363 200931 3033 55750 253782 8714 10728 5445 5446 11332 9926 29095 56848 129642 8611 8612 6555 6554 51003 5587 23760 23761 3284 3283 23646 54675 8605 6305 6307 3291 23659 1594 3290 123099 1591 3294 51171 3292 120227 51170 57834 79603 8613 8871 5305 4036 80736 10558 7329 211 55304 56994 151742 23396 8867 10554 9971 5130 8760 25816 80724 221 222 3635 171586 10449 6579 146850 8879 5294 23533 10682 79837 79626 5007 91734 9915 9967 4051 8897 8895 375 590 142891 231 4048 84320 51763 126282 200879 63874 29956 64600 23179 240 241 5728 242 23171 246 247 248 414149 30814 11283 64850 5287 5288 9885 165679 377 51302 1460 9517 33 34 1459 35 5297 5298 1457 9536 9415 39 4594 8560 5293 166785 1800 51552 84693 54947 43 374986 9420 162466 84129 347516 2629 51205 11145 65977 9791 5096 23259 51573 54600 50486 32 9429 50487 5095 6296 127281 10390 64419 56910 117245 51102 51588 1718 54979 11010 10162 23597 183 55711 85465 51478 2819 84498 91012 9107 9468 26279 10809 196 55289 27242 81579 9968 26031 9969 84725 27124 22908 2948 641371 134526 158835 22925 7179 158833 56261 57110 204962 27132 388931 1622 255189 10948 283871 9108 8877 80230 91452 8398 8399 375775 9489 255043 27349 10908 9362 79153 8394 79152 8395 283748 1632 80142 112812 9256 26027 134429 57491 5783 79143 1646 1645 122618 154141 9023 403313 1892 81490 130367 57153 64801 259230 59339 59338 2876 1666 84879 124976 58488 5338 50640 80270 151056 2638 2879 94103 93492 59344 94101 27306 8503 29841 117145 3972 3992 1571 123745 1565 84895 2531 8776 5920 9572 30849 90809 5289 90390 5286 8898 8821 9896 55361 9217 9110 22876 57761 200576 6095 54893 55300 54545 55697 3631 4534 5501 5295 5296 5290 5291 133522 58526 1376 5500 788 1375 9600 4199 1040 57605 83394 10423 1584 8644 2224 2222 3157 1595 6721 1717 10654 6309 9453 4047 4520 3422 4598 6713 7108 26119 51360 51128 51129 8029 116519 213 335 336 5566 5567 5568 8720 9871 9632 10427 5320 5499 239 47 9200 9524 79071 376497 64834 2194 401494 23205 23305 79993 84869 253017 201562 51144 55301 11001 11000 54898 5538 31 197322 51703 2180 6785 22880 9374 3293 2182 5264 81616 2181 23600 51495 79966 283927 83401 7923 390916 109703458 60481 6319 9218 6901 25942 8540 8310 5563 2053 10891 5565 30 8309 10478 51422 8443 3155 122970 5901 9261 10005 1384 54677 81857 3295 10802 10484 51179 2101 570 6720 215 55825 1024 6342 857 26063 10965 3930 1962 26061 79644 4952 10498 405 406 10025 5443 1081 4056 892 10001 112937 5465 3074 3073 1586 79411 411 2720 89944 29079 37 3032 3030 5467 5468 5469 7421 5337 9862 2033 6256 56623 9663 8694 392636 2173 2171 2170 80168 84649 2820 2169 116255 2168 2167 6257 150379 8228 346606 11343 2172 646486 6907 3991 64900 8648 646480 2713 79718 2712 2710 51099 150763 23175 84246 7376 10226 9612 10062 8841 9611 19 123 23054 9443 9441 9442 2874 54797 5346 55090 9440 80306 8202 29906 51586 948 9439 81849 23097 6837 6613 219541 23389 55588 6483 9412 400569 6487 5476 7296 2678 9477 2687 112950 10825 4862 1374 30815 80205 57104 8800 4597 85441 8396 10499 96764 9575 7069 1387 6667 8647 8869 79611 4800 4801 4802 2877 4758 10599 4759 10555 9282 5660 7368 339221 ERBB2 REGULATES CELL MOTILITY%REACTOME%R-HSA-6785631.4 ERBB2 Regulates Cell Motility 2064 1950 1956 9542 10718 51072 145957 3084 685 1729 2069 387 1839 REGULATION OF EXPRESSION AND FUNCTION OF TYPE II CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 95%9764260 Regulation of Expression and Function of Type II Classical Cadherins 1499 3728 6667 4343 192669 23112 27327 26523 192670 27161 57690 28513 2294 80149 56978 9839 8728 6663 1495 64403 27319 80332 1006 26508 1500 51129 3224 3609 6615 1009 SIGNALING BY EGFRVIII IN CANCER%REACTOME%R-HSA-5637812.3 Signaling by EGFRvIII in Cancer 11140 3320 1950 5335 2549 867 1956 5295 6464 6654 4893 5290 3265 TOXICITY OF BOTULINUM TOXIN TYPE F (BOTF)%REACTOME%R-HSA-5250981.4 Toxicity of botulinum toxin type F (botF) 6844 22987 9899 6843 9900 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME%R-HSA-163680.7 AMPK inhibits chREBP transcriptional activation activity 79602 51422 51094 9370 5563 6794 5565 51085 MITF-M-DEPENDENT GENE EXPRESSION%REACTOME%R-HSA-9856651.3 MITF-M-dependent gene expression 60 23405 427 4308 5829 3978 2766 6595 6597 6599 6598 9114 51606 9550 523 526 6663 527 208 6601 6603 528 6602 6605 529 6604 8992 597 634 4233 7837 3065 7299 25942 79083 3094 2315 1029 595 3662 1000 83439 6490 1017 994 1638 5454 1026 533 10085 1499 6935 51176 6909 727936 4935 6932 4644 6934 7015 5873 79444 8289 54843 201595 25924 5054 7391 3673 7306 10891 4343 192669 23112 27327 999 26523 192670 27161 7020 57690 1729 5977 605 8110 891 6657 26039 5347 6760 596 672 1432 57492 9274 4174 9275 4171 23411 8193 86 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 95%75815 Ubiquitin-dependent degradation of Cyclin D 5706 5707 5708 5709 595 1019 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 9861 6233 5687 5688 5689 2932 7316 10213 RRNA PROCESSING IN THE MITOCHONDRION%REACTOME%R-HSA-8868766.4 rRNA processing in the mitochondrion 29960 81554 51335 84881 51106 3028 54931 9692 60528 22868 285367 26995 387338 55178 130916 51001 79922 INTERLEUKIN-1 PROCESSING%REACTOME DATABASE ID RELEASE 95%448706 Interleukin-1 processing 3606 1511 3552 834 4790 4791 3553 5970 79792 PIWI-INTERACTING RNA (PIRNA) BIOGENESIS%REACTOME%R-HSA-5601884.3 PIWI-interacting RNA (piRNA) biogenesis 3320 54514 5434 5435 5436 5437 5438 5439 5430 201164 5431 5432 5433 221400 122402 55124 84944 54456 11022 91646 4603 113802 8468 9271 56165 136991 143689 5440 5441 HSF1 ACTIVATION%REACTOME DATABASE ID RELEASE 95%3371511 HSF1 activation 3320 3297 10728 1915 3281 6117 7415 10013 6119 7531 3326 6118 DISEASES OF BASE EXCISION REPAIR%REACTOME%R-HSA-9605308.6 Diseases of Base Excision Repair 4968 79661 4913 55247 BINDING OF TCF LEF:CTNNB1 TO TARGET GENE PROMOTERS%REACTOME%R-HSA-4411364.5 Binding of TCF LEF:CTNNB1 to target gene promoters 6932 6934 864 83439 1499 51176 8313 4609 HIV LIFE CYCLE%REACTOME%R-HSA-162587.5 HIV Life Cycle 5045 55048 89853 1104 51534 9525 137492 6881 27183 51271 51160 155382 93343 7251 79720 5902 51510 905 129685 2547 7520 3981 7518 348995 9883 6396 129401 9688 920 79643 57122 51652 23225 3836 4927 3159 23165 11168 9397 55746 55706 23636 9631 91782 7175 9972 11097 23279 8086 92421 23511 53371 51616 8480 79023 79902 10762 8815 5903 3978 54457 27243 128866 2961 2960 10015 2959 2958 2957 29082 25978 4836 83860 6872 6874 6873 6908 2237 5905 6880 6883 6882 6884 6875 6878 8812 6877 6879 5901 6233 7852 7316 1234 6921 6923 7514 5440 8732 5441 4331 8021 8731 1022 2071 2966 6829 2965 2963 5478 8148 2962 2068 5434 5435 5436 5437 5438 5439 2968 2967 8178 22916 404672 5430 25920 4686 5431 138474 5432 51224 5433 6924 7936 902 6827 6749 9150 6917 1025 51497 7469 11198 904 7311 7314 23327 G ALPHA (Q) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 95%416476 G alpha (q) signalling events 2846 553 5332 594857 64106 301 129521 128674 2867 3827 2865 2863 2862 60675 4922 4923 10800 2869 10235 8620 10125 680 27334 84634 3060 5367 23620 3710 3062 3061 10316 4828 4829 2642 2641 26575 2520 84539 7222 7225 2847 57121 9170 57113 3708 23566 3709 1902 1128 1133 1131 7204 5330 5331 23236 3358 3357 5598 1839 3356 8997 146 147 148 3269 4935 5731 5737 6915 5580 695 5578 2793 2792 2791 5581 2790 156 2788 2787 2786 2785 6197 2784 6196 2783 51764 6195 9630 94235 5588 2864 55970 183 54331 2767 59345 2769 115557 2782 2776 10681 1956 4893 8503 5594 5595 6654 6288 3265 11343 5583 9162 8527 26090 8525 8526 5295 57406 5296 221955 160851 1609 747 5290 1608 1607 1606 139189 5020 4295 7200 5021 7201 431704 56413 5031 5032 6003 1909 1908 6004 94233 2798 2797 2796 1907 5028 1906 84432 5029 6375 1241 551 2693 1910 84109 10874 29933 222545 10887 5724 10886 257313 64407 387129 2911 2358 846 2915 8111 8477 2922 5996 2147 5997 5998 6870 5999 6863 2925 6865 6846 6866 10161 6869 185 351 623 624 4314 10287 56923 8490 2151 2150 57105 2149 2829 2828 353299 885 886 887 2837 347148 9002 338557 3814 10911 2840 552 COLLAGEN CHAIN TRIMERIZATION%REACTOME DATABASE ID RELEASE 95%8948216 Collagen chain trimerization 1307 84570 1306 1297 1284 50509 1282 1286 1281 1285 256076 169044 1280 81578 255631 57642 1310 340267 7373 136227 1278 131873 1277 91522 1296 80781 1295 1294 1293 1292 1291 1290 1305 1303 1302 1301 1289 1300 1288 1287 1299 85301 1298 1308 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME%R-HSA-168179.3 Toll Like Receptor TLR1:TLR2 Cascade 6279 6885 7186 7189 79155 7157 6280 7097 7096 7335 10454 64127 929 8945 114609 59307 11213 5970 841 7334 6271 8517 3146 23643 5594 5595 1386 7099 57162 5604 5598 51231 1849 84166 1147 1848 6285 1846 6288 1845 92610 6283 51295 51135 4214 8651 9684 4793 28512 57161 79671 3551 177 4615 121457 246330 5599 28511 3656 257397 23118 1326 5609 466 80216 6416 4208 5601 7867 5602 5606 5519 5515 5516 5518 6233 8767 948 3654 9261 7316 695 5528 4791 5608 2244 2266 2243 9097 23291 11274 1432 10333 4792 10392 7311 6197 7314 6196 351 4790 9252 6195 8454 4205 2353 5600 2002 6500 3725 KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450604.4 KSRP (KHSRP) binds and destabilizes mRNA 51010 167227 51013 207 11340 8570 118460 5600 23404 54512 22894 5393 1432 7534 56915 23016 5073 LOSS OF FUNCTION OF KMT2D IN MLL4 COMPLEX FORMATION IN KABUKI SYNDROME%REACTOME%R-HSA-9944997.1 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome 5929 84661 11091 8085 9070 REGULATION OF TP53 DEGRADATION%REACTOME%R-HSA-6804757.3 Regulation of TP53 Degradation 253260 1029 6446 207 1017 9099 983 1616 900 472 5519 7157 5170 55615 5515 7311 7874 5516 64223 7314 117584 5518 51230 6233 2475 208 10000 5527 7316 80196 890 8900 11200 4194 79109 4193 DEFECTIVE B4GALT1 CAUSES CDG-2D%REACTOME DATABASE ID RELEASE 95%4793953 Defective B4GALT1 causes CDG-2d 2683 DEFECTIVE PAPSS2 CAUSES SEMD-PA%REACTOME DATABASE ID RELEASE 95%3560796 Defective PAPSS2 causes SEMD-PA 9060 INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME%R-HSA-163754.4 Insulin effects increased synthesis of Xylulose-5-Phosphate 7086 6888 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190375 FGFR2c ligand binding and activation 2251 8823 8074 8817 2249 26281 2247 2246 2254 RUNX1 REGULATES EXPRESSION OF COMPONENTS OF TIGHT JUNCTIONS%REACTOME DATABASE ID RELEASE 95%8935964 RUNX1 regulates expression of components of tight junctions 7122 100506658 861 865 7082 RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME DATABASE ID RELEASE 95%110314 Recognition of DNA damage by PCNA-containing replication complex 7398 51514 10714 5424 8451 5425 5981 57804 5982 56655 5983 57599 7320 5426 5427 1642 54107 7311 5111 7314 56852 6233 9978 6117 7316 5984 5985 6119 6118 BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME%R-HSA-77352.5 Beta oxidation of butanoyl-CoA to acetyl-CoA 35 142827 1892 6296 3033 CHROMATIN MODIFICATIONS DURING THE MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9821002.1 Chromatin modifications during the maternal to zygotic transition (MZT) 474382 54145 10765 8970 8331 8337 128312 8334 8335 8370 29128 55766 8968 23135 8341 8342 8347 8348 94239 285051 8345 200424 3013 8340 7403 5927 8338 359787 255626 124512 3021 57379 653604 3018 3017 85236 3014 8349 REGULATION OF PD-L1(CD274) TRANSLATION%REACTOME%R-HSA-9909620.2 Regulation of PD-L1(CD274) translation 4343 192669 23112 27327 26523 192670 27161 57690 29126 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%R-HSA-73780.4 RNA Polymerase III Chain Elongation 84265 55703 11128 51728 27297 5434 661 5435 9533 10623 5437 171568 55718 10622 10621 51082 5440 5441 MET RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 95%6806942 MET Receptor Activation 4233 6692 3249 10653 3083 3082 PI3K CASCADE%REACTOME DATABASE ID RELEASE 95%109704 PI3K Cascade 2252 2251 8074 2249 2248 2247 57761 2246 2323 2322 152831 8823 5295 5296 5140 2264 5781 5290 5291 5170 27006 2255 117145 9846 54106 3667 2549 8660 30849 10818 208 8817 26281 9965 5289 2254 PEXIDARTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702605.2 pexidartinib-resistant FLT3 mutants 2322 VRNA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%192814 vRNA Synthesis 142 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME DATABASE ID RELEASE 95%1912399 Pre-NOTCH Processing in the Endoplasmic Reticulum 4851 4853 4854 4855 23509 56983 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 95%109703 PKB-mediated events 208 5140 POTASSIUM CHANNELS%REACTOME%R-HSA-1296071.4 Potassium Channels 55970 54331 59345 27094 2782 27345 10681 3778 3779 10242 3781 9424 3775 3751 10089 3752 3754 3755 131096 56659 3756 3757 3758 3770 338567 9196 27012 27133 10021 3780 3782 3783 26251 3776 3777 51305 3790 348980 9132 170850 57657 3784 3785 3786 3787 3788 7881 83795 23416 9312 93107 23415 169522 54207 50801 3737 56479 3738 3760 3739 3761 610 2550 81033 3759 3736 90134 3750 3772 3748 3749 89822 3741 8514 3742 3743 3744 3745 3746 3747 3762 3763 3765 3766 3768 3773 9568 2793 2792 2791 2790 2788 2787 2786 2785 2784 2783 51764 94235 10060 3764 6833 3767 SMOOTH MUSCLE CONTRACTION%REACTOME%R-HSA-445355.8 Smooth Muscle Contraction 3693 7414 301 7169 8654 7094 7168 10174 2983 493829 8291 2982 25802 58498 302 217 4629 93408 859 10580 7170 10627 140465 103910 7171 29895 4637 8912 800 8913 8911 309 4636 4638 808 10398 3672 5829 5058 2977 5062 AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%R-HSA-1428517.8 Aerobic respiration and respiratory electron transport 5018 1327 92259 1329 1340 1337 1339 1351 4706 1350 1349 1347 1346 1345 7350 125965 38 2395 613227 516 150274 498 4697 28976 4728 4729 27089 4720 137872 4723 4724 4725 4967 4726 3421 6233 25915 55572 29090 4731 152100 93058 728294 100996939 3420 116228 7316 4190 28958 4191 4508 55101 4509 1355 51660 51300 8604 1353 374291 10873 3419 50 10632 3418 3313 90639 7352 4512 1537 7351 4513 347411 4514 6389 10063 55471 4519 80775 54949 2110 119559 160287 81889 6391 6390 6392 2108 55245 10975 122961 51204 2109 9551 4540 285521 4541 9556 6834 4535 1431 84233 4536 4537 4538 7385 7384 617 7386 7311 7388 80219 7314 7381 83733 84701 25880 80224 51103 2805 4200 23410 389203 509 284184 10165 4694 4695 4696 506 2271 5091 79133 57226 4714 51241 126328 513 54205 8802 514 515 10131 8803 55967 517 8801 518 55969 25994 25874 84833 1743 81689 521 522 29796 440957 57001 92483 644096 9481 27109 84987 57128 100303755 55744 55863 148811 539 10476 790955 4722 54539 91942 9016 728568 3948 79944 2739 3945 90871 341947 440567 23530 3052 29078 90624 100131801 137682 192286 751071 4705 9997 79751 4707 4708 4709 291 135154 84300 4700 4701 4702 4704 6341 8402 79064 4716 493753 4717 4718 4719 51079 4710 4711 4712 4713 4698 54902 4715 7416 51295 9377 5166 3954 9167 5162 5163 5164 5165 23409 64795 4199 4750 64777 8050 5160 5161 57546 55066 3939 79018 54994 10296 1737 4289 25852 2954 2806 80232 10048 54704 1738 2875 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 95%72163 pre-mRNA splicing 4904 10915 10594 7737 10236 11325 55749 27238 63932 9130 10921 11338 4236 79706 57819 4116 84081 6430 25949 6432 6431 79171 1660 22794 8175 23524 1655 4809 10450 6427 91603 6426 9939 6429 57703 6428 1659 23658 51729 5356 55094 27336 27339 79165 1665 26121 84991 10465 163859 25804 3181 3188 65109 3187 3185 3184 79753 55660 2521 7536 9716 51503 51747 3192 3191 23517 3190 23759 9295 10569 83443 51634 7307 51759 3178 7919 3312 5440 5441 2963 2962 5434 5435 5436 5437 5438 5439 5430 5431 5432 5433 6434 10250 27316 3183 51428 51639 53938 8896 51645 10772 11193 24148 55696 24144 8899 55100 23020 85313 143884 10992 9879 9410 8683 10084 9775 23398 9092 3550 22985 55234 55110 8559 5725 58509 10523 6936 9785 10291 59286 79576 199746 9416 8449 10179 58517 10181 51690 51691 57794 11157 10189 4670 22938 151903 51340 10713 5511 55702 22826 22827 10284 5411 10283 153527 8241 5093 5094 60625 84811 22916 51593 23350 4686 10286 10285 988 11017 9584 9343 6632 6631 10929 57461 84844 56259 51362 6625 6627 6626 6629 135295 6628 220988 10262 27258 84950 10946 23450 23451 54883 6634 56949 6633 6636 5546 6635 6638 6637 9128 9129 10907 26017 9360 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 95%111461 Cytochrome c-mediated apoptotic response 22900 55075 57099 5594 5595 51074 331 840 842 317 836 54205 56616 DEVELOPMENTAL LINEAGE OF MAMMARY STEM CELLS%REACTOME DATABASE ID RELEASE 95%9938206 Developmental Lineage of Mammary Stem Cells 2255 MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-5684264.4 MAP3K8 (TPL2)-dependent MAPK1 3 activation 8517 7311 7314 3551 4790 8454 6233 1326 23291 7316 6416 6500 5604 1147 8945 79155 SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 95%8985586 SLIT2:ROBO1 increases RHOA activity 9353 387 6091 4650 DISEASES ASSOCIATED WITH O-GLYCOSYLATION OF PROTEINS%REACTOME%R-HSA-3906995.5 Diseases associated with O-glycosylation of proteins 92949 170691 56667 11093 7057 145173 57188 2591 143662 79695 10417 118430 11041 10418 9215 170689 29954 171019 54437 9510 9037 4582 5199 4583 7058 4584 4585 10585 4586 55624 200958 1605 157869 727897 29071 9507 140766 80070 9508 9509 10071 3955 94025 339366 221981 79875 81794 140453 55901 4588 4589 81792 4851 283463 4853 9719 4854 56999 4855 56913 394263 11173 11096 11095 11174 80731 170690 54507 170692 INLB-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL%REACTOME%R-HSA-8875360.5 InlB-mediated entry of Listeria monocytogenes into host cell 6456 4233 6455 2060 867 6457 7311 7314 9146 6233 10254 8027 7316 30011 SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME DATABASE ID RELEASE 95%5358493 Synthesis of diphthamide-EEF2 89978 92715 1938 51611 285381 120526 1802 1801 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%R-HSA-532668.4 N-glycan trimming in the ER and Calnexin Calreticulin cycle 7841 2923 91445 55741 6048 5700 10956 9761 811 64772 80267 84447 10299 55768 23193 9695 10206 7415 56886 267 821 51035 7844 11253 5589 55757 11236 79139 51009 6400 7311 7314 6233 7316 5887 NUCLEOTIDE CATABOLISM DEFECTS%REACTOME DATABASE ID RELEASE 95%9735786 Nucleotide catabolism defects 4860 PCP CE PATHWAY%REACTOME%R-HSA-4086400.4 PCP CE pathway 163 23002 5216 5879 1175 1173 409 144165 1212 4920 8321 8325 7471 81029 4919 6259 57154 9861 6233 7316 5880 5578 10213 50855 57216 5706 5707 5708 5709 5700 5701 5702 5704 64750 5705 5682 5683 5684 5685 5686 5717 5718 5719 1855 11047 5582 5881 5713 5579 5714 7481 5690 5691 5692 1857 5693 1856 5694 54361 7976 7311 7855 7979 5695 7314 8322 23513 8323 5687 5688 1213 5689 1211 2535 7474 8324 387 160 161 SIGNALING BY FGFR2 AMPLIFICATION MUTANTS%REACTOME%R-HSA-2023837.3 Signaling by FGFR2 amplification mutants 2263 SIGNALING BY RHO GTPASES, MIRO GTPASES AND RHOBTB3%REACTOME DATABASE ID RELEASE 95%9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3 57498 2319 9414 708 6709 9146 1828 1832 10134 10971 7204 55075 55160 23365 9181 128272 57580 10211 26230 121512 1894 10451 7410 84904 26084 23370 25791 89846 9826 9828 7409 23229 22899 50649 8997 6453 7984 29 8874 64857 57449 2245 23263 5300 50650 221472 995 9639 10672 10276 55701 5879 9459 9138 4168 27237 7074 6655 11214 5924 4221 9738 367 695 7428 1072 908 5579 7532 7531 7533 10376 8239 55288 60 10254 8027 65124 55200 399693 1080 253959 4722 23616 56667 57636 57630 55219 5825 64283 1362 22852 55227 26092 91544 1124 2697 10409 6811 91452 27289 348995 832 10970 6396 4649 10505 57679 6711 5880 57122 114885 79598 3336 284119 25 27145 4548 57579 57216 55746 253980 10963 4690 5783 55968 54514 4580 23279 55852 8086 4698 11113 10144 25963 79023 79834 79902 2185 23433 667 5903 79822 54908 9928 6232 6793 8655 25909 5585 5586 8379 9183 3163 1063 54438 1062 5338 7415 157285 91010 9184 9938 1060 23779 8502 1855 991 54443 151648 9824 5361 55166 752 5364 1058 7535 8503 79019 998 9855 9732 151246 25813 9735 224 1857 6472 1856 23332 11180 11060 57591 8776 79003 1152 5594 94240 55055 5595 29941 81565 85415 22919 30849 348235 11188 10818 84681 5048 23421 6242 8301 220134 11075 57082 1495 120 23380 57405 84317 51143 9748 23141 147841 4085 8440 64105 94134 9528 401541 10403 7126 387 390 81624 391 5289 388 26999 6654 389 23129 54820 399 80776 222584 701 51566 54821 171177 23256 378708 286205 9322 84144 1781 23122 55704 70 1780 23002 2802 65992 79172 5099 1778 81930 9217 55920 55831 51479 84643 114793 54509 55717 29984 3796 9462 5216 10810 5217 1730 9793 80005 91687 22800 57551 537 93663 79682 26049 9590 5905 57473 1783 5501 5295 7170 3688 5296 9231 7171 83540 123720 80152 2491 80115 5519 158747 332 5290 57120 55143 8153 699 5170 63916 6722 84986 11243 9497 51466 50618 71 157769 84612 3619 140735 114822 5515 57381 11004 3954 5516 445582 808 5518 58480 9212 2631 25936 29843 11130 2886 1795 64946 79980 1742 1794 10726 1793 1729 152273 5525 79180 5526 23074 55839 23197 5527 5528 5500 5529 6714 1445 10817 5347 4659 3932 182 1629 1213 6249 6279 4628 79784 4629 3984 3985 103910 4637 4627 6280 2316 23221 29766 55023 7919 5756 124540 3326 87 1499 55004 4638 999 5580 8773 7514 50508 5578 7444 6510 2909 9743 57584 7534 392 9341 394 5062 395 1536 10811 397 1535 10458 55843 10979 9815 7879 55845 4688 4689 7529 10298 10652 3998 9235 9710 81839 10489 23092 55971 143872 347902 1829 4810 55619 85360 8936 1432 10424 10787 5881 27 10152 64411 124056 2010 23344 143098 2889 29127 4983 613 857 8987 3930 55789 51347 5600 26050 3071 4162 7112 7037 5058 10163 28964 80728 22865 23191 653361 23592 23075 116984 55114 27035 11135 4952 1969 10006 55914 4001 7431 9475 8452 6434 8654 10250 9886 27316 23013 9352 6093 3183 11329 56254 2873 79869 5930 10574 51138 9318 10576 4646 1627 4296 10928 115557 23048 26030 80243 54874 79658 64130 83478 7454 9754 7456 115703 2040 139818 201176 10788 57514 51133 26286 9901 64333 9644 116985 23268 147179 57480 117289 57522 3895 9912 50855 51306 8826 11140 343578 3320 9411 50619 221178 101059918 124997 58504 257106 1123 23526 5063 4650 898 153478 57144 644150 393 55240 396 398 1027 84364 5337 29062 148170 51291 5590 8970 3728 8331 144402 8976 8337 85440 128312 90627 8334 8476 56990 8335 81704 23348 89839 8370 57569 55766 23580 8968 10395 10435 92799 8341 10160 8342 9578 8347 25894 57572 8348 23513 94239 10602 8345 3013 128239 56924 8340 8338 255626 3021 653604 3018 3017 200894 85236 3014 8349 474382 54145 23028 10226 66008 22836 4771 3798 3799 4660 2017 54763 10398 9927 10109 55669 10552 10093 10092 10095 10094 10097 2810 10096 64837 354 51209 94274 89953 89941 147700 9367 3817 22906 23081 3831 30851 5910 9055 80179 51517 10499 5747 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME%R-HSA-5423646.6 Aflatoxin activation and detoxification 2678 1544 124975 2687 64174 2686 8574 1800 22977 1577 1553 4257 91703 4258 4259 95 246181 1576 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%R-HSA-113501.5 Inhibition of replication initiation of damaged DNA by RB1 E2F1 23649 5422 5557 5558 5515 7027 5516 5518 28227 7029 1869 5925 5519 DEFECTIVE F8 CLEAVAGE BY THROMBIN%REACTOME%R-HSA-9672391.2 Defective F8 cleavage by thrombin 2147 2157 7450 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME%R-HSA-400508.4 Incretin synthesis, secretion, and inactivation 23478 2922 60559 2782 2864 28972 2695 90701 139760 1803 2784 51764 1499 2626 6934 1045 3952 346562 3670 338557 2641 5122 9789 5080 DOPAMINE RECEPTORS%REACTOME%R-HSA-390651.4 Dopamine receptors 1812 1816 1815 1814 1813 PROCESSING AND ACTIVATION OF SUMO%REACTOME DATABASE ID RELEASE 95%3215018 Processing and activation of SUMO 7341 6612 6613 205564 10055 59343 25950 7329 10054 29843 SUMOYLATION OF RNA BINDING PROTEINS%REACTOME DATABASE ID RELEASE 95%4570464 SUMOylation of RNA binding proteins 23636 9631 7175 9972 11097 23279 8086 23511 53371 8480 3190 79023 79902 10762 5903 3183 51602 8535 7341 6045 648 6015 7329 1912 1911 80012 57332 348995 84733 9883 6396 7703 129401 6613 9688 57122 23225 4927 23165 55746 8021 55706 SHC-MEDIATED CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 95%5654719 SHC-mediated cascade:FGFR4 2251 8074 2249 2247 2246 152831 8823 8817 26281 9965 2264 6654 4893 2254 3265 DISEASES OF BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-HSA-9865118.1 Diseases of branched-chain amino acid catabolism 594 10295 1892 1629 1738 593 38 64087 152926 26275 56922 549 3712 SIGNALING BY RAF1 MUTANTS%REACTOME%R-HSA-9656223.2 Signaling by RAF1 mutants 673 8826 2244 2266 7414 8844 10256 54518 5894 22866 5906 4140 5908 7450 2243 7094 1445 7529 369 283455 408 409 4893 808 5594 5595 3690 3674 815 6714 5604 816 5605 817 818 2335 3265 3717 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 95%381426 Regulation of IGF Activity by IGFBP 10618 6696 7076 5611 718 3956 4924 3053 26085 2999 721 213 8614 335 3827 2519 336 375056 10272 174 1435 54972 3698 84141 8720 9210 11098 462 54587 5340 4312 7425 4313 29106 7184 6694 334 1462 7018 338 10970 5768 3913 3895 3915 2335 80341 1511 57719 3912 4052 652 3569 2200 102 8074 3371 11320 1000 4148 1758 6383 5589 4221 348 2719 354 3817 2266 2243 57104 10130 3485 3483 54757 51246 5265 8404 2621 2147 8542 1471 3491 3490 2153 3489 5624 3481 3488 3487 7466 351 64856 197 10117 3479 3816 1114 258 7857 11167 10232 5954 1356 56955 4240 4241 5179 255738 3270 265 401138 51156 5034 91851 5069 147111 3486 51280 3484 56975 116519 813 60676 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3315487.4 SMAD2 3 MH2 Domain Mutants in Cancer 4087 4088 4089 SIGNALING BY CTNNB1 PHOSPHO-SITE MUTANTS%REACTOME%R-HSA-4839743.5 Signaling by CTNNB1 phospho-site mutants 5515 5516 5518 1499 5525 5526 8312 2932 5527 324 5528 1452 5529 139285 5519 REGULATION OF IFNA IFNB SIGNALING%REACTOME DATABASE ID RELEASE 95%912694 Regulation of IFNA IFNB signaling 3716 3440 5777 8651 3452 3451 9021 3454 7297 3449 3448 3447 3446 3445 3444 3443 3456 5770 11274 5781 3442 6773 3441 REGULATION OF SIGNALING BY CBL%REACTOME%R-HSA-912631.3 Regulation of signaling by CBL 8503 29760 867 2889 5293 1398 4067 5295 1399 5296 7525 7409 2534 6850 3055 5290 5291 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME%R-HSA-381771.6 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 23478 2922 60559 2782 2864 28972 90701 139760 1803 2784 51764 1499 6934 1045 3952 346562 338557 2641 5122 9789 5080 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 95%399956 CRMPs in Sema3A signaling 5362 10371 2242 1020 55558 2932 8851 8829 10570 1809 91584 56896 2534 1400 1808 5361 3-HYDROXYISOBUTYRYL-COA HYDROLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9916722 3-hydroxyisobutyryl-CoA hydrolase deficiency 26275 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 95%74751 Insulin receptor signalling cascade 2252 2251 8074 2249 2887 2248 2247 57761 2246 2323 2322 152831 8823 5295 5296 6464 5140 2264 5781 4893 5290 5291 5170 27006 2255 117145 9846 3630 54106 3667 2549 8660 5594 5595 30849 10818 208 3643 8817 26281 9965 5289 6654 2254 3265 NFG AND PRONGF BINDS TO P75NTR%REACTOME%R-HSA-205017.3 NFG and proNGF binds to p75NTR 4803 4804 REGULATION OF COMPLEMENT CASCADE%REACTOME%R-HSA-977606.8 Regulation of Complement cascade 629 718 7448 721 1991 1378 710 3080 4179 1361 1380 10877 2147 10878 730 731 27202 732 5627 930 733 975 712 735 1191 713 81494 714 715 716 717 719 3078 3075 1370 3426 1369 722 966 725 727 728 729 1604 PKA-MEDIATED PHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 95%163358 PKA-mediated phosphorylation of key metabolic factors 5207 5566 5567 5568 51085 ATTACHMENT OF BACTERIA TO EPITHELIAL CELLS%REACTOME%R-HSA-9638630.1 Attachment of bacteria to epithelial cells 11045 4072 FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190374 FGFR1c and Klotho ligand binding and activation 8074 GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 95%6814848 Glycerophospholipid catabolism 375775 284161 10908 79153 51573 133121 81544 ICOS CO-STIMULATION%REACTOME DATABASE ID RELEASE 95%9927354 ICOS co-stimulation 8503 146850 5294 5295 5293 5296 23533 5290 5291 23308 FOXO-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-9614085.3 FOXO-mediated transcription 3065 25942 10370 2660 1026 901 6794 10891 27113 5443 2308 1647 1649 5105 3066 356 5934 23460 2290 8850 65018 2810 114907 4852 6648 7534 2538 4087 4088 207 4089 56729 7295 7529 694 1027 2908 4287 6720 1387 9314 10971 2033 3630 10628 57060 604 7532 847 181 10018 857 4303 4800 4801 4802 23410 23411 208 10000 2309 84676 91584 2645 3484 FORMATION OF APOPTOSOME%REACTOME DATABASE ID RELEASE 95%111458 Formation of apoptosome 22900 55075 57099 51074 331 842 5594 317 5595 54205 56616 FORMATION OF THE NON-CANONICAL BAF (NCBAF) COMPLEX%REACTOME DATABASE ID RELEASE 95%9933947 Formation of the non-canonical BAF (ncBAF) complex 23506 6597 65980 6599 29998 60 9274 9275 26039 6601 6603 6602 6760 6604 605 6595 86 TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME%R-HSA-9694676.4 Translation of Replicase and Assembly of the Replication Transcription Complex 91782 23479 25978 92421 30849 81631 7405 79643 51652 27243 5289 128866 8678 29082 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME%R-HSA-888590.3 GABA synthesis, release, reuptake and degradation 6844 22999 6540 2572 18 2571 80331 10815 5864 140679 6616 6538 6857 6529 7915 6539 3312 6804 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH MUTYH%REACTOME DATABASE ID RELEASE 95%9605310 Defective Base Excision Repair Associated with MUTYH APOPTOTIC EXECUTION PHASE%REACTOME DATABASE ID RELEASE 95%75153 Apoptotic execution phase 7431 4001 3024 1499 3009 100506658 3008 3007 6093 3006 3005 22985 6304 999 5580 118 51765 28988 324 3836 8428 5062 9414 329 2339 6709 10059 3837 841 1828 1832 63967 1830 2934 1829 839 10134 5317 660 3148 7082 3146 2620 5339 4137 1677 1676 5747 840 5588 836 BRIGATINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 95%9717319 brigatinib-resistant ALK mutants 238 DISEASES OF DNA REPAIR%REACTOME DATABASE ID RELEASE 95%9675135 Diseases of DNA repair 4436 4292 5395 4437 2956 7486 5982 5883 5884 5983 116028 3364 472 10635 672 675 84126 83990 144715 4968 83695 5810 7516 10111 5932 7979 4361 7156 5890 9156 55247 5892 4683 11073 580 10524 641 1763 545 6117 79661 5984 5985 6119 4913 79728 5888 6118 80010 5889 INTERLEUKIN-1 FAMILY SIGNALING%REACTOME%R-HSA-446652.9 Interleukin-1 family signaling 90865 9173 6885 8808 27179 27177 56300 26525 84639 7186 7189 79155 7157 29110 7335 10454 64127 79792 8945 5783 1511 59307 3552 11213 3553 5970 841 5780 5782 5784 8809 54472 5778 8807 7334 7850 4215 84867 26095 11141 5781 3557 3565 27178 10068 5771 3596 26469 25930 8517 3146 3606 57162 6774 5604 84166 1147 6285 6288 92610 6283 51135 9684 4793 28512 57161 79671 3551 177 8878 4615 121457 246330 5599 28511 3656 5775 257397 23118 1326 80216 6416 9861 6233 8767 3654 9978 7316 10213 4791 5608 5706 5707 5708 5709 4088 5700 5701 240 5702 9097 5704 5705 5682 23291 5683 5684 5685 5686 5717 5718 834 5719 11274 11047 5713 5714 5690 5777 5691 5692 5693 4792 5694 10392 7311 7979 5695 7314 351 4790 8454 5687 5688 5689 6500 3554 DEFECTIVE SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5660724.4 Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) 6531 BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME%R-HSA-9026290.3 Biosynthesis of DPAn-3-derived maresins 239 240 TRNA-DERIVED SMALL RNA (TSRNA OR TRNA-RELATED FRAGMENT, TRF) BIOGENESIS%REACTOME%R-HSA-9708296.3 tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis 283 60528 23405 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%R-HSA-112382.4 Formation of RNA Pol II elongation complex 905 8812 6921 6923 5440 5441 4331 1022 2071 2966 6829 2965 2963 2962 2068 5434 5435 5436 5437 5438 5439 2968 8178 2967 22916 404672 5430 25920 4686 5431 5432 51224 5433 6924 7936 902 6827 6749 9150 6917 1025 51497 7469 11198 904 4298 6830 27125 23168 55840 4300 85403 79577 55677 80349 123169 9646 54623 ARACHIDONATE PRODUCTION FROM DAG%REACTOME DATABASE ID RELEASE 95%426048 Arachidonate production from DAG 26090 57406 221955 11343 747 MRNA EDITING: C TO U CONVERSION%REACTOME%R-HSA-72200.6 mRNA Editing: C to U Conversion 200315 339 9582 10930 27350 29974 164668 403314 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%R-HSA-1679131.3 Trafficking and processing of endosomal TLR 7184 54106 81622 7098 1520 5641 51311 10695 1508 1514 1513 51284 1515 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-HSA-181438.3 Toll Like Receptor 2 (TLR2) Cascade 6279 6885 7186 7189 79155 7157 6280 7097 7096 7335 10454 64127 929 8945 114609 59307 11213 5970 841 7334 6271 8517 3146 23643 5594 5595 1386 7099 57162 5604 5598 51231 1849 84166 1147 1848 6285 1846 6288 1845 92610 6283 51295 51135 4214 8651 9684 4793 28512 57161 79671 3551 177 4615 121457 246330 5599 28511 3656 257397 23118 1326 5609 466 80216 6416 4208 5601 7867 5602 5606 5519 5515 5516 5518 6233 8767 948 3654 9261 7316 695 5528 4791 5608 2244 2266 2243 9097 23291 11274 1432 10333 4792 10392 7311 6197 7314 6196 351 4790 9252 6195 8454 4205 2353 5600 2002 6500 3725 MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME%R-HSA-429958.5 mRNA decay by 3' to 5' exoribonuclease 51010 51013 11340 80349 118460 6499 23404 54512 22894 9652 10767 115024 5393 28960 56915 23016 SIGNALING BY MST1%REACTOME DATABASE ID RELEASE 95%8852405 Signaling by MST1 6692 3249 4485 10653 4486 HH MUTANTS ARE DEGRADED BY ERAD%REACTOME DATABASE ID RELEASE 95%5362768 Hh mutants are degraded by ERAD 5706 5707 5708 5709 5700 5701 5702 10956 5704 5705 5682 84447 5683 5684 5685 5686 7415 5717 5718 5719 27248 11047 5713 5714 51009 5690 5691 5692 5693 6400 5694 7311 7979 5695 7314 9861 6233 5687 5688 5689 7316 6469 10213 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 95%110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 142 10714 5424 5425 5981 57804 3978 5982 56655 2237 5983 5423 5426 5427 10038 54107 5111 6117 5984 5985 6119 6118 8505 54936 328 PHENYLKETONURIA%REACTOME DATABASE ID RELEASE 95%2160456 Phenylketonuria 5053 NS1 MEDIATED EFFECTS ON HOST PATHWAYS%REACTOME DATABASE ID RELEASE 95%168276 NS1 Mediated Effects on Host Pathways 23636 3839 9631 7175 2633 9972 402569 11097 3840 23279 3841 8086 23511 53371 8480 79023 79902 10762 3837 5903 3838 5610 348995 9883 6396 8106 129401 9688 10898 57122 9636 23225 3836 197259 4927 23165 55746 8021 55706 RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME DATABASE ID RELEASE 95%8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 474382 3065 84661 54145 25942 861 865 11091 5929 23309 4343 192669 23112 27327 3276 26523 192670 9739 57690 8850 10398 9070 2811 8085 7057 9757 58508 8970 5196 8331 4297 8337 128312 8334 8335 2033 8370 55766 8968 8341 4778 2623 8342 8347 8348 94239 8345 3013 161882 8340 8013 8338 3674 255626 3021 653604 5588 3018 23067 3017 85236 3014 55170 8349 ALKBH3 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME%R-HSA-112126.3 ALKBH3 mediated reversal of alkylation damage 221120 51008 84164 10973 DEFECTIVE CYP26B1 CAUSES RHFCA%REACTOME DATABASE ID RELEASE 95%5579015 Defective CYP26B1 causes RHFCA 56603 NEUTROPHIL DEGRANULATION%REACTOME%R-HSA-6798695.3 Neutrophil degranulation 5611 2760 5023 2519 2717 2268 410 427 79888 5175 719 28988 966 929 728 79792 1604 6386 80331 6709 5864 6616 353376 3837 1828 1832 54472 2934 8904 1378 5317 3146 55860 1508 102 5663 23385 84061 23601 1650 22875 2548 51125 2665 10890 374395 10549 2799 10855 201294 4973 2207 1118 5879 1116 2204 1476 80301 932 5834 10875 5836 27180 3310 81619 2215 2212 945 2219 3684 29108 2352 116844 387263 10857 114790 2588 6947 5870 124583 960 961 388698 2357 963 388697 965 221 968 3689 6836 5869 22931 3579 3577 976 978 5878 6727 4680 83716 8895 338339 55276 4317 127829 4048 4318 5478 6993 4332 10493 160364 3240 3482 4282 79930 56729 8804 240 23218 5553 5795 1075 140885 5787 302 1265 5788 5547 6518 4353 1088 353189 25840 1084 56954 6402 1460 11322 5799 5315 23317 29099 55754 10120 8836 11333 5328 8560 5329 23406 8972 51552 64114 126014 3043 8621 4125 4126 89777 10694 57826 170482 23412 683 684 566 6317 11314 9961 4033 8876 25801 210 5236 64386 51071 10383 10326 101 56888 55313 7305 8635 10321 11010 9725 10562 326624 441864 6590 84329 84443 51646 5273 54918 1823 5036 138050 29952 199675 5269 8778 53831 5284 26 154664 9522 9535 8566 401258 5049 51316 6036 9545 11026 55 7133 6286 11031 25798 25797 7130 6282 387921 2919 374403 10394 11240 10970 290 175 178 150372 10159 7276 23114 3903 55832 23593 10043 10288 80142 1727 9342 9588 100049587 3916 51806 222487 83858 81567 2950 22918 51816 1512 1992 57126 8288 57153 7077 1522 9145 57020 6793 8655 258010 1654 1774 3163 84766 3848 58485 7415 93100 84514 79169 2992 3608 2517 94103 53916 4893 53917 26578 1315 5912 84658 5806 23071 84418 2896 4831 5594 527 1509 51143 387 391 634 51382 1778 54509 5873 535 10312 158747 79980 1794 1729 23197 7414 51411 25852 5724 2358 5265 197 12 1 10577 3920 161 3615 3614 121260 383 5906 5908 6278 4057 6279 6037 10487 728358 671 5473 5657 10450 967 4069 5004 7226 6280 7097 10533 5005 5768 6556 1669 8993 8673 1511 2683 10075 823 1991 4860 3934 272 353 820 5645 5646 47 1915 11001 9218 8514 3326 3107 3106 23352 51719 3417 28956 30 55004 8649 5580 9861 3312 8773 10213 203068 5707 1536 5708 5709 1535 3683 7879 5701 5702 1520 5683 5686 5717 5718 5719 1432 80184 5713 847 5695 4790 8987 3304 5689 3071 23200 317 23191 79895 1675 718 8907 6093 6515 567 10576 2495 340061 2512 2547 7520 2990 2040 10788 3074 2444 64333 411 2720 23250 8826 4718 3320 196527 23526 10396 5337 5199 3728 3685 8694 2171 6283 1938 3687 9761 1143 948 10092 10097 5223 51209 230 5476 2821 327 3101 5211 4257 226 4311 1471 5777 3958 4758 10555 9798 5660 TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME%R-HSA-937072.4 TRAF6-mediated induction of TAK1 complex within TLR4 complex 7311 7314 23643 7099 6233 353376 3656 257397 6885 23118 10454 7316 929 7189 148022 REGULATION OF PTEN LOCALIZATION%REACTOME%R-HSA-8948747.6 Regulation of PTEN localization 4734 7316 331 7311 7874 7314 6233 5371 5728 MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 95%8875513 MET interacts with TNS proteins 4233 84951 3688 64759 3082 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 95%1963642 PI3K events in ERBB2 signaling 2064 1950 2549 1956 9542 10718 145957 3084 685 2069 5295 1839 5290 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%R-HSA-2468052.4 Establishment of Sister Chromatid Cohesion 114799 10735 23063 5885 10274 157570 8243 9126 23244 113130 23047 GLUCURONIDATION%REACTOME%R-HSA-156588.6 Glucuronidation 54659 23169 11046 7363 133688 7365 7364 7367 7366 7360 54490 80146 79799 54578 54577 55347 54576 574537 54575 54600 54658 54657 54579 7358 167127 10941 10720 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME%R-HSA-380108.6 Chemokine receptors bind chemokines 6351 6352 58191 6354 6357 6356 6348 6347 6349 2826 10850 6361 9034 6364 6363 6366 6367 1230 6360 2833 643 10663 6373 6372 6374 6376 6370 1238 2921 57007 5473 2920 1237 1236 1233 729230 3576 1232 56477 4283 6387 6346 10803 51554 10563 3627 2919 7852 1234 3579 3577 1524 1235 6375 5196 6846 2829 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME%R-HSA-76046.4 RNA Polymerase III Transcription Initiation 5434 5435 5437 6908 51082 84265 55703 112495 11128 51728 9330 27297 661 9533 2976 10623 2975 5451 2972 6621 171568 55290 55814 6619 9328 2971 9329 7702 55718 10622 6618 10302 10621 6617 5440 5441 TALDO1 DEFICIENCY: FAILED CONVERSION OF SH7P, GA3P TO FRU(6)P, E4P%REACTOME DATABASE ID RELEASE 95%6791055 TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P 6888 SERINE METABOLISM%REACTOME DATABASE ID RELEASE 95%977347 Serine metabolism 57515 10955 256987 113675 619189 26227 5723 10993 347735 29968 63826 TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME%R-HSA-166020.4 Transfer of LPS from LBP carrier to CD14 3929 929 EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME%R-HSA-3928663.5 EPHA-mediated growth cone collapse 9475 10398 6093 4628 4067 79784 4629 25791 7525 103910 387 4637 2534 4627 NEF-MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS%REACTOME%R-HSA-164938.5 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 163 51606 10053 8907 1175 8905 130340 1173 1174 920 162 55690 164 3105 940 567 926 160 3932 161 375 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 95%169893 Prolonged ERK activation events 673 4803 2889 5906 5594 5595 10818 4914 57498 7529 1398 1399 5604 5605 NEUROPHILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME DATABASE ID RELEASE 95%194306 Neurophilin interactions with VEGF and VEGFR 8829 3791 8828 2321 NUCLEAR EVENTS STIMULATED BY ALK SIGNALING IN CANCER%REACTOME DATABASE ID RELEASE 95%9725371 Nuclear events stimulated by ALK signaling in cancer 5551 597 29851 3587 3065 51530 6776 7291 3662 4869 891 2305 1051 3002 5925 6194 7535 4343 192669 5777 26523 192670 27161 5594 57690 5595 8454 9978 3726 1786 6774 6500 SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 95%2142712 Synthesis of 12-eicosatetraenoic acid derivatives 246 2876 2877 239 2879 59344 242 CHOLESTEROL BIOSYNTHESIS VIA DESMOSTEROL (BLOCH PATHWAY)%REACTOME%R-HSA-6807047.3 Cholesterol biosynthesis via desmosterol (Bloch pathway) 1595 1717 1718 6309 50814 6307 10682 7108 51478 3930 DEFECTIVE DHDDS CAUSES RP59%REACTOME%R-HSA-4755609.4 Defective DHDDS causes RP59 79947 116150 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%R-HSA-202433.5 Generation of second messenger molecules 4690 5335 9402 3123 3122 3120 55740 5063 3119 3937 3118 3117 3115 3113 915 27040 916 917 9398 2533 3127 3126 3125 3702 3932 7535 51466 7454 5058 920 7408 5336 5062 FCGR3A-MEDIATED PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 95%9664422 FCGR3A-mediated phagocytosis 10006 60 10810 2268 9844 4644 5879 4627 63916 71 7454 7456 10109 1398 1793 10552 10093 10092 10095 4067 10094 10097 695 10096 147179 25 4690 10458 51517 55845 4650 644150 917 2534 4651 8976 8936 6850 3055 4620 10787 4641 2214 10152 998 5594 5595 10451 7410 3071 10163 5747 7525 7409 23191 26999 IMPAIRED BRCA2 BINDING TO RAD51%REACTOME DATABASE ID RELEASE 95%9709570 Impaired BRCA2 binding to RAD51 7486 5982 5883 5884 5983 116028 3364 472 672 675 84126 83990 144715 83695 5810 10111 5932 7979 4361 7156 9156 4683 11073 580 10524 641 1763 545 6117 5984 5985 6119 5888 6118 80010 SENSORY PROCESSING OF SOUND%REACTOME%R-HSA-9659379.3 Sensory processing of sound 7430 10083 64787 222662 83715 783 389207 2059 5756 51475 5962 6853 140469 2036 6855 4627 8573 6804 490 3778 3779 832 9381 6711 80331 6709 5864 55584 3781 57053 6616 2934 4478 829 4641 129446 440699 25861 27445 161497 6844 124590 51168 11344 64072 9132 8927 4647 53904 494513 9750 9478 259236 65217 23136 339768 117532 117531 25794 283310 340990 246213 643226 830 286262 375611 4354 10518 776 5357 53405 9254 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%R-HSA-198725.4 Nuclear Events (kinase and transcription factor activation) 6457 6446 7166 6236 2152 3399 4066 8941 8061 466 3727 1785 7425 4208 3400 2354 10221 4664 4665 1959 5519 1958 3398 3397 23237 6722 1961 1960 429 5515 5516 5518 9261 5528 1108 6938 4209 1020 8851 1432 5978 2033 6197 6196 5594 5595 9252 6195 1386 4205 2353 5600 3726 2002 5598 51231 1849 1848 1846 1845 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%R-HSA-2173789.6 TGF-beta receptor signaling activates SMADs 3693 5045 3694 7046 4087 867 7048 4088 7040 4089 9110 5499 64750 4092 51377 23645 9958 5501 3688 8516 4052 4054 7049 10273 7311 57154 7314 9040 2280 25805 6233 3696 56937 11171 3690 8425 4738 3685 7316 7514 5500 7043 7042 23327 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%R-HSA-1358803.2 Downregulation of ERBB2:ERBB3 signaling 9101 208 2064 10193 10000 7316 7311 9542 7314 207 6233 3084 VASOPRESSIN-LIKE RECEPTORS%REACTOME%R-HSA-388479.4 Vasopressin-like receptors 553 554 5020 5021 551 552 EICOSANOIDS%REACTOME%R-HSA-211979.3 Eicosanoids 57834 66002 11283 8529 284541 1582 5740 1580 4051 6916 126410 1579 TICAM1, RIP1-MEDIATED IKK COMPLEX RECRUITMENT%REACTOME%R-HSA-168927.5 TICAM1, RIP1-mediated IKK complex recruitment 8737 8517 7098 329 7311 7314 3551 7323 7322 6233 11035 7335 330 7316 7334 1147 7189 148022 7321 GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 95%9953170 GBP-mediated host defense 2342 5045 2633 71 5292 2339 115361 2635 115362 2634 60 5229 2810 834 PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME%R-HSA-427975.4 Proton oligopeptide cotransporters 51296 6564 121260 DEFECTIVE HEXB CAUSES GM2-GANGLIOSIDOSIS 2%REACTOME%R-HSA-3656248.4 Defective HEXB causes GM2-gangliosidosis 2 3074 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-427413.4 NoRC negatively regulates rRNA expression 474382 3065 54145 25942 6908 23309 51082 7343 3066 9533 11176 8467 79685 29115 5440 5441 4331 1022 25885 2071 79595 2966 2965 2068 5434 10284 5435 64425 5437 7270 79101 2968 2967 10849 404672 902 221830 8970 8819 8331 8932 8337 128312 8334 8335 9014 9015 9013 8370 55766 8968 84172 8341 8342 8347 8348 94239 8345 3013 1789 8340 1786 64426 8338 255626 3021 51742 653604 3018 3017 85236 3014 30834 8349 MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9683673.5 Maturation of protein 3a 6480 256435 10610 6483 6482 6484 2589 27090 6487 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 95%5250941 Negative epigenetic regulation of rRNA expression 474382 3065 54145 25942 6908 23309 51082 7343 3066 9533 11176 8467 23378 79685 6839 29115 5440 5441 4331 1022 25885 2071 79595 2966 2965 2068 5434 10284 5435 64425 5437 7270 79101 2968 2967 10849 404672 902 221830 8970 8819 8331 8932 8337 128312 8334 8335 9014 9015 9013 8370 55766 8968 84172 8341 8342 8347 8348 94239 8345 3013 1789 8340 1786 23411 64426 8338 255626 3021 51742 653604 3018 3017 85236 3014 30834 8349 TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME%R-HSA-69560.4 Transcriptional activation of p53 responsive genes 57060 1026 25946 7157 RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%8951671 RUNX3 regulates YAP1-mediated transcription 7004 7003 7005 864 25937 8463 1490 10413 NEGATIVE REGULATION OF MET ACTIVITY%REACTOME DATABASE ID RELEASE 95%6807004 Negative regulation of MET activity 5771 9101 6456 4233 6455 2060 867 6457 7311 7314 26018 9146 6233 10254 5795 8027 7316 5770 30011 3082 NEGATIVE REGULATION OF FLT3%REACTOME DATABASE ID RELEASE 95%9706369 Negative regulation of FLT3 867 7311 7314 6233 10019 1445 8835 2323 9306 5795 6503 2322 84174 7316 27 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME%R-HSA-5696395.2 Formation of Incision Complex in GG-NER 2071 2966 2965 2068 142 1069 2968 8451 2967 404672 2073 2072 902 85015 7334 9557 7336 7341 10038 2067 8554 1642 7311 7329 7507 7508 7314 1643 10401 6233 9978 6612 6613 6117 7316 54778 6119 5886 6118 5887 4331 1022 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%R-HSA-2562578.3 TRIF-mediated programmed cell death 8772 11035 8737 23643 929 7099 353376 841 148022 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME DATABASE ID RELEASE 95%174184 Cdc20:Phospho-APC C mediated degradation of Cyclin A 9861 6233 7316 10213 51529 7321 5706 8881 64682 5707 25906 5708 11065 8697 5709 7324 10393 29945 27338 119504 5700 5701 29882 5702 246184 983 996 5704 51434 5705 51433 5682 5683 5684 5685 5686 5717 9184 5718 5719 991 11047 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 5687 5688 5689 4085 890 8900 701 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 95%159234 Transport of Mature mRNAs Derived from Intronless Transcripts 23636 55339 9631 7175 9972 11097 23279 8086 23511 10482 53371 8480 79023 79902 10762 5903 22916 29894 4686 7884 1977 53981 8189 348995 9883 6396 129401 81608 9688 51692 10898 57122 23225 10189 4927 23165 55746 8021 55706 MYD88-INDEPENDENT TLR4 CASCADE%REACTOME DATABASE ID RELEASE 95%166166 MyD88-independent TLR4 cascade 6885 7187 7186 7189 79155 7157 3661 29110 8772 10010 7335 9641 3665 10454 64127 929 8945 8737 329 5970 353376 841 11035 330 7334 5781 148022 8517 3146 23643 5594 5595 1386 7099 5604 5598 51231 1849 84166 1147 1848 6285 1846 6288 1845 92610 6283 9684 4793 28512 79671 3551 177 121457 5599 28511 3656 257397 23118 1326 5609 466 80216 6416 4208 5601 7867 5602 5606 5519 5515 5516 5518 7323 6233 7322 8767 3654 9261 7316 5528 4791 7321 5608 9097 10133 23291 11274 1432 4792 10392 7311 6197 7314 6196 351 4790 9252 6195 8454 4205 2353 5600 2002 6500 3725 TOXICITY OF TETANUS TOXIN (TETX)%REACTOME%R-HSA-5250982.4 Toxicity of tetanus toxin (tetX) 6844 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME DATABASE ID RELEASE 95%2046106 alpha-linolenic acid (ALA) metabolism 10005 60481 3992 64834 2180 9415 6342 3295 30 215 83401 54898 SIGNALING BY ERBB2 IN CANCER%REACTOME DATABASE ID RELEASE 95%1227990 Signaling by ERBB2 in Cancer 11140 3320 2064 1950 5335 2549 55914 1956 9542 10718 145957 3084 685 5782 2069 5295 1839 6464 6654 4893 5290 3265 TRIF (TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME%R-HSA-937061.5 TRIF (TICAM1)-mediated TLR4 signaling 6885 7187 7186 7189 79155 7157 3661 29110 8772 10010 7335 9641 3665 10454 64127 929 8945 8737 329 5970 353376 841 11035 330 7334 5781 148022 8517 3146 23643 5594 5595 1386 7099 5604 5598 51231 1849 84166 1147 1848 6285 1846 6288 1845 92610 6283 9684 4793 28512 79671 3551 177 121457 5599 28511 3656 257397 23118 1326 5609 466 80216 6416 4208 5601 7867 5602 5606 5519 5515 5516 5518 7323 6233 7322 8767 3654 9261 7316 5528 4791 7321 5608 9097 10133 23291 11274 1432 4792 10392 7311 6197 7314 6196 351 4790 9252 6195 8454 4205 2353 5600 2002 6500 3725 INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 95%140837 Intrinsic Pathway of Fibrin Clot Formation 2 2147 2158 3053 5624 5627 708 3827 7450 462 2161 2811 5547 2160 5270 2812 2157 3818 5104 2815 710 2814 2159 SIGNALING BY PLASMA MEMBRANE FGFR1 FUSIONS%REACTOME%R-HSA-8853336.2 Signaling by plasma membrane FGFR1 fusions 2260 11160 9530 EPHRIN SIGNALING%REACTOME%R-HSA-3928664.4 Ephrin signaling 6386 2048 8874 2047 1949 1948 1947 5063 5879 5058 8440 28964 10627 2534 2051 2050 5062 2049 LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME DATABASE ID RELEASE 95%140534 Ligand-dependent caspase activation 8797 8737 355 356 8717 23643 7099 353376 8743 841 8772 929 8795 7186 148022 SIGNALING BY ERBB2%REACTOME DATABASE ID RELEASE 95%1227986 Signaling by ERBB2 11140 9101 3320 1950 2064 10193 5335 55914 4145 1956 207 5782 5295 6464 2534 5581 4893 5290 26469 10273 2549 8065 7311 9542 10718 7314 51072 145957 5580 6233 2886 3084 685 1729 2069 208 10000 7316 5578 6714 5753 7525 1839 387 6654 3265 DEFECTIVE CP CAUSES ACERULOPLASMINEMIA (ACERULOP)%REACTOME%R-HSA-5619060.3 Defective CP causes aceruloplasminemia (ACERULOP) 1356 30061 GABA B RECEPTOR ACTIVATION%REACTOME%R-HSA-977444.5 GABA B receptor activation 113 114 3772 115 2774 107 108 55970 109 196883 3762 3763 3765 3766 3768 54331 59345 2793 2792 3773 346562 2791 2790 2788 2782 2787 2786 2785 2784 2783 51764 10681 9568 2771 2770 94235 3760 3761 2550 3759 111 112 2773 FCGR3A-MEDIATED IL10 SYNTHESIS%REACTOME%R-HSA-9664323.3 FCGR3A-mediated IL10 synthesis 113 114 115 5335 107 108 109 196883 5566 5567 5568 2268 2209 917 3586 3710 5573 2534 6850 5575 5576 3055 5577 5613 2214 2212 10768 808 4067 3708 3709 7525 5336 111 112 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190373 FGFR1c ligand binding and activation 2251 7049 8074 10755 2249 3730 26281 2247 2246 2254 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME%R-HSA-975138.5 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation 6885 7186 7189 79155 7157 7335 10454 64127 929 8945 5970 353376 841 7334 148022 8517 3146 23643 5594 5595 1386 7099 57162 5604 5598 51231 1849 84166 1147 1848 6285 1846 6288 1845 92610 6283 51295 51135 4214 9684 4793 28512 57161 79671 3551 177 4615 121457 246330 5599 28511 3656 257397 23118 1326 5609 466 80216 6416 4208 5601 7867 5602 5606 5519 54106 5515 5516 5518 6233 8767 3654 9261 7316 5528 4791 5608 9097 23291 11274 1432 4792 10392 7311 6197 7314 6196 351 4790 9252 6195 8454 4205 2353 5600 2002 6500 3725 51284 HIV ELONGATION ARREST AND RECOVERY%REACTOME DATABASE ID RELEASE 95%167287 HIV elongation arrest and recovery 6829 2963 2962 5434 5435 5436 5437 5438 5439 8178 25920 5430 5431 51224 5432 6924 5433 7936 6827 6749 9150 6917 905 1025 51497 7469 11198 904 8812 6921 6923 5440 5441 SIGNALING BY ERBB2 KD MUTANTS%REACTOME%R-HSA-9664565.3 Signaling by ERBB2 KD Mutants 11140 3320 2064 1950 5335 2549 55914 1956 9542 10718 145957 3084 685 2069 5295 1839 6464 6654 4893 5290 3265 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME DATABASE ID RELEASE 95%75892 Platelet Adhesion to exposed collagen 8515 7450 51206 3672 2207 4067 2811 3673 2812 3688 2534 2815 2814 11093 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 95%77595 Processing of Intronless Pre-mRNAs 55339 10914 51585 1479 10978 1478 1477 53981 8189 22916 29894 8106 4686 81608 11051 51692 10898 23283 79869 SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME DATABASE ID RELEASE 95%4090294 SUMOylation of intracellular receptors 7341 5914 5468 4929 51588 8554 7329 5241 7181 9759 10401 7421 2516 6095 2099 5465 6612 6613 7068 367 7376 6256 2908 4306 DEFECTIVE ALG11 CAUSES CDG-1P%REACTOME%R-HSA-4551295.4 Defective ALG11 causes CDG-1p 440138 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 95%73863 RNA Polymerase I Transcription Termination 2071 2966 2965 2068 5434 5435 64425 5437 7270 79101 2968 2967 10849 404672 6908 902 221830 51082 9014 9015 9013 7343 84172 9533 5440 284119 5441 30834 4331 1022 25885 DAG1 CORE M2 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 95%8932504 DAG1 core M2 glycosylations 29954 146664 10585 55624 1605 CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME DATABASE ID RELEASE 95%5607763 CLEC7A (Dectin-1) induces NFAT activation 4772 5534 10768 3710 3708 3709 808 4773 4775 5530 5532 LTC4-CYSLTR MEDIATED IL4 PRODUCTION%REACTOME%R-HSA-9664535.2 LTC4-CYSLTR mediated IL4 production 57105 2678 2687 64174 1800 10800 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%R-HSA-69656.6 Cyclin A:Cdk2-associated events at S phase entry 595 91750 993 132660 1017 7465 994 286826 1026 1875 55957 1874 5928 4609 5934 9861 6233 7316 10213 4331 1022 5706 5707 5708 5709 7027 207 1019 5700 5701 5702 898 5704 51343 6502 5705 5682 5683 9134 5684 1027 5685 902 5686 4149 7029 1869 5717 5718 5925 5719 91768 11047 5713 5714 5690 5691 5692 5693 5694 1163 7311 7979 5695 7314 8454 5687 5688 5689 208 10000 890 8900 5753 6500 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 95%3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists 54361 4040 22943 7483 4041 89780 6423 11197 6422 27121 79412 83999 27123 7474 50964 TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME%R-HSA-1299316.3 TWIK-releated acid-sensitive K+ channel (TASK) 3777 51305 REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME%R-HSA-5686938.6 Regulation of TLR by endogenous ligand 3929 10333 2244 6271 2266 3146 23643 6280 7097 7096 2243 7099 338 948 6279 1687 51284 929 79792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME%R-HSA-5654696.3 Downstream signaling of activated FGFR2 2252 27006 2255 2251 8074 5335 2549 2249 2248 2247 10818 2246 10817 8823 8817 5295 26281 5781 6654 4893 5290 2254 3265 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME%R-HSA-382556.6 ABC-family proteins mediated transport 10058 8714 91445 6048 335 91319 5244 10956 5824 8894 9619 64241 64240 1965 1080 1968 5825 21 23460 9861 6233 7316 10213 5706 5707 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 7415 5717 10057 5718 11194 5719 23456 23457 10349 27248 89845 11047 79139 85320 215 26154 10347 5713 20 5714 51009 22 5690 23 5691 24 5692 6400 5243 8504 5693 340273 5694 368 10350 7311 64137 7979 5695 23461 7314 10351 11160 5687 10257 5688 5689 225 1244 10060 10613 3767 4363 DEFECTIVE ADA DISRUPTS (DEOXY)ADENOSINE DEAMINATION%REACTOME DATABASE ID RELEASE 95%9734735 Defective ADA disrupts (deoxy)adenosine deamination 100 DEFECTIVE GFPT1 CAUSES CMSTA1%REACTOME DATABASE ID RELEASE 95%4085023 Defective GFPT1 causes CMSTA1 2673 PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION%REACTOME DATABASE ID RELEASE 95%9660826 Purinergic signaling in leishmaniasis infection 718 1511 3552 3553 5025 5970 3326 7295 114548 834 5027 29108 10628 4790 4210 10910 4907 953 957 9051 3606 719 3162 4791 79792 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME DATABASE ID RELEASE 95%2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 2252 2251 8074 2249 2248 2247 57761 2246 2323 2322 152831 8823 5295 5296 5140 2264 5781 4893 5290 5291 5170 27006 2255 117145 9846 54106 3667 2549 3481 8660 3479 30849 10818 8471 3480 8483 208 8817 26281 9965 5289 6654 2254 3265 CASP4 INFLAMMASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 95%9948001 CASP4 inflammasome assembly 808 1992 837 DEFECTIVE REGULATION OF TLR7 BY ENDOGENOUS LIGAND%REACTOME DATABASE ID RELEASE 95%9824856 Defective regulation of TLR7 by endogenous ligand 51284 ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME%R-HSA-2395516.3 Electron transport from NADPH to Ferredoxin 112812 2232 2230 HDMS DEMETHYLATE HISTONES%REACTOME%R-HSA-3214842.5 HDMs demethylate histones 7404 23081 23028 9682 10765 221656 8370 8968 23135 55818 7403 22992 5927 51780 84864 8242 5253 653604 23210 23133 8284 55693 23030 84159 80853 84678 PHOSPHORYLATION OF EMI1%REACTOME DATABASE ID RELEASE 95%176417 Phosphorylation of Emi1 5347 891 991 26271 983 51343 DEFECTIVE SLC35A2 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2M (CDG2M)%REACTOME%R-HSA-5619072.3 Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M) 7355 RHOV GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013424 RHOV GTPase cycle 171177 8826 4690 8874 1969 6709 9815 79834 10298 667 9352 81839 57473 5295 7170 9231 7171 8976 4296 998 57630 84612 11180 9738 55789 56924 1213 4649 5058 8440 6711 28964 94134 79598 8239 50855 5062 RND3 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9696264 RND3 GTPase cycle 5783 1969 57449 55704 54514 29766 9462 667 27316 1828 1832 9352 6093 81839 5295 5296 9231 8502 56667 1362 11180 22852 91544 1152 857 11188 23513 55789 8301 10970 10505 7126 2909 390 2319 57584 23592 3895 394 222584 57216 253980 TRIGLYCERIDE BIOSYNTHESIS%REACTOME%R-HSA-75109.8 Triglyceride biosynthesis 80168 84649 116255 57678 346606 64900 2713 2712 2710 150763 23175 9663 8694 392636 RESISTANCE OF ERBB2 KD MUTANTS TO TRASTUZUMAB%REACTOME DATABASE ID RELEASE 95%9665233 Resistance of ERBB2 KD mutants to trastuzumab 11140 3320 2064 55914 SEALING OF THE NUCLEAR ENVELOPE (NE) BY ESCRT-III%REACTOME%R-HSA-9668328.2 Sealing of the nuclear envelope (NE) by ESCRT-III 10383 91782 200014 260334 10382 112714 92421 7846 84790 27183 84617 113457 27243 7280 128866 347733 7277 7278 29082 25978 79861 81027 10376 6683 80086 347688 79643 51652 9798 51807 221496 10381 SIGNALING BY CSF1 (M-CSF) IN MYELOID CELLS%REACTOME DATABASE ID RELEASE 95%9680350 Signaling by CSF1 (M-CSF) in myeloid cells 146433 139716 867 9402 1435 8563 5295 6772 6464 2534 5781 3636 3055 5290 5291 9846 7311 5293 7314 3845 6233 1436 4067 3635 7316 6774 6714 7525 6654 5336 BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME%R-HSA-5620922.5 BBSome-mediated cargo-targeting to cilium 22948 166379 55212 117177 6608 92482 8195 10694 84100 2847 10575 582 583 129880 6950 54585 7203 585 6753 27241 10576 123016 79738 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 95%77286 mitochondrial fatty acid beta-oxidation of saturated fatty acids 35 3030 142827 51102 1892 6296 33 37 34 3033 3032 SIGNALING BY NOTCH1%REACTOME%R-HSA-1980143.4 Signaling by NOTCH1 83464 51107 7088 7089 3065 92737 10013 8788 7091 1272 113878 10014 1840 6907 79718 9734 6868 51564 3714 9612 408 8841 409 9611 23493 3516 4609 892 23220 3066 9759 23462 8850 6233 3280 9978 3091 79885 7316 55869 8650 22938 55534 83933 83737 9794 2648 1387 2033 28514 26960 1024 182 7311 7314 84441 8454 9148 10046 54492 4851 142678 26508 388585 6500 57534 102 54567 5663 23385 55851 5664 RESISTANCE OF ERBB2 KD MUTANTS TO NERATINIB%REACTOME DATABASE ID RELEASE 95%9665246 Resistance of ERBB2 KD mutants to neratinib 11140 3320 2064 55914 GDP-FUCOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%6787639 GDP-fucose biosynthesis 7264 8790 55343 282969 197258 2762 MYD88 DEFICIENCY (TLR5)%REACTOME DATABASE ID RELEASE 95%5602680 MyD88 deficiency (TLR5) 7100 4615 PYRIMIDINE CATABOLISM%REACTOME%R-HSA-73621.4 Pyrimidine catabolism 1806 51733 84618 64902 30833 56953 7378 4907 151531 1890 1807 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190322 FGFR4 ligand binding and activation 152831 2251 8823 8074 8817 2249 26281 2247 9965 2264 2246 2254 DISEASES OF THE NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 95%9675143 Diseases of the neuronal system 24 611 64220 7276 9227 5950 5959 222236 6017 145226 5956 5947 2652 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250347.5 SHC1 events in ERBB4 signaling 2069 9542 10718 145957 1839 6464 6654 4893 3084 685 3265 CTNNB1 T41 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 95%5358752 CTNNB1 T41 mutants aren't phosphorylated 5515 5516 5518 1499 5525 5526 8312 2932 5527 324 5528 1452 5529 139285 5519 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-HSA-6804116.5 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 1820 57060 1017 1026 144455 898 25946 9134 1027 79733 890 8900 1869 7157 CLEC7A (DECTIN-1) SIGNALING%REACTOME DATABASE ID RELEASE 95%5607764 CLEC7A (Dectin-1) signaling 3551 257397 6885 23118 3710 9020 997 10892 84433 7189 64170 5170 64581 5971 29108 808 5580 9861 6233 7322 7335 10454 7316 3708 3709 10213 4791 8945 7321 5706 5707 5708 5709 4773 3553 5700 4775 5701 5970 5702 841 5704 5705 5682 23291 5683 5684 5685 5686 7334 5717 5718 5719 6850 11047 5713 4772 5714 5690 5534 9039 5691 5692 10768 8517 4792 5693 5694 7311 7979 5695 7314 4790 9040 8454 5530 5687 5532 5688 5689 8915 6500 1147 5336 FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME%R-HSA-173599.4 Formation of the active cofactor, UDP-glucuronate 80146 23169 7358 11046 7360 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 95%112040 G-protein mediated events 113 114 5332 115 2774 107 108 109 196883 5566 5567 5568 2767 3710 5153 346562 2769 5321 2776 808 5580 5136 815 2771 5578 2770 3708 3709 816 817 818 2773 5573 5575 5576 5577 5582 5613 156 3838 5137 10645 10768 26960 84254 814 5594 5330 5331 23236 9630 111 112 RHOB GTPASE CYCLE%REACTOME%R-HSA-9013026.2 RHOB GTPase cycle 29 55914 70 23002 23263 5099 9475 50650 9639 10276 6093 9138 4168 5295 5296 11214 65124 115557 64283 9754 2040 1729 4649 8773 2909 9743 2319 284119 57584 392 9341 394 9414 11113 4650 6793 5585 81839 5586 398 23092 3728 54443 90627 55160 23365 10395 9181 29127 57580 4983 613 29941 10211 857 85415 1894 55789 6242 128239 7410 4162 9748 7037 9826 80728 9828 81624 388 7984 ABO BLOOD GROUP BIOSYNTHESIS%REACTOME%R-HSA-9033807.2 ABO blood group biosynthesis 2523 28 2524 NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME%R-HSA-5674499.2 Negative feedback regulation of MAPK pathway 673 5894 5604 5594 5605 5595 DEFECTIVE MMAB CAUSES MMA, CBLB TYPE%REACTOME DATABASE ID RELEASE 95%3359471 Defective MMAB causes MMA, cblB type 326625 SCAVENGING BY CLASS F RECEPTORS%REACTOME%R-HSA-3000484.3 Scavenging by Class F Receptors 3320 10525 8578 10808 338 811 BACTERIAL INFECTION PATHWAYS%REACTOME DATABASE ID RELEASE 95%9824439 Bacterial Infection Pathways 2633 5045 6456 4233 6455 2060 6457 11045 1938 4072 3326 10254 4057 1499 8027 5609 4843 6416 567 6804 999 2931 115361 3040 163351 2984 7097 2634 808 112755 79849 6233 7322 79872 127833 5987 7316 6714 3836 7296 3320 5230 1511 4360 867 7879 837 6616 9146 2023 6857 11151 3837 26276 5868 6421 10015 6844 51606 7311 7314 5594 5595 3043 57674 1500 80824 5604 1839 5605 928 22987 9899 6843 30011 9900 MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9694719.4 Maturation of protein 3a 6480 256435 10610 6483 6482 6484 2589 27090 6487 TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME%R-HSA-6803205.2 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 1121 604 8626 7159 10397 9540 5875 5876 79370 23368 64065 7161 332 7157 DEFECTIVE MTRR CAUSES HMAE%REACTOME DATABASE ID RELEASE 95%3359467 Defective MTRR causes HMAE 4548 4552 SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME%R-HSA-1483248.8 Synthesis of PIPs at the ER membrane 5297 8898 6305 22908 55300 UPTAKE AND FUNCTION OF ANTHRAX TOXINS%REACTOME DATABASE ID RELEASE 95%5210891 Uptake and function of anthrax toxins 5609 5045 6416 5604 808 5605 10015 CELL CYCLE%REACTOME DATABASE ID RELEASE 95%1640170 Cell Cycle 7298 200014 260334 7083 4926 26003 27436 5928 5931 5933 5934 4605 79643 51652 91782 22974 92421 4869 3837 5981 56655 7334 7336 27243 128866 5426 5427 10971 29082 25978 54107 3306 80028 23194 995 29935 10926 2237 55388 7341 7329 9738 84962 9978 4067 11200 4194 5440 5441 4331 1022 4193 5434 5435 5436 5437 5438 5439 5430 5431 5432 5433 902 113457 7280 1460 1459 5579 1457 7532 5111 7531 7533 84142 10376 9577 80086 51807 10381 10383 10382 51588 112714 55135 91750 993 132660 7846 7465 84790 286826 9088 2305 55957 10051 10592 84617 54892 29781 23310 79648 347733 7277 7278 7157 29086 79861 4292 81027 6241 348995 9883 6396 51720 129401 9688 8607 57122 23225 25 4927 23165 55746 55706 23636 9631 7175 9972 11097 23279 8086 23511 53371 8480 79023 79902 10762 8815 5903 54908 6232 8655 25909 63967 8379 9183 1063 1062 9184 1060 991 151648 55166 79184 1058 79019 151246 9735 23332 79003 5594 55055 81565 51230 22919 348235 5048 23421 220134 55835 57082 57405 51143 208 23141 147841 4085 64105 401541 10403 54820 80776 701 54821 378708 1781 23122 1780 79172 1778 81930 55920 84643 1876 3796 1875 1874 9793 7015 91687 57551 79682 5905 1783 5501 83540 80152 2491 5519 332 55143 699 11243 387893 3619 140735 5515 11004 5516 5518 9212 25936 11130 64946 79980 8468 10726 5525 5526 55839 5527 5528 5500 5529 51529 7321 3717 8881 64682 25906 11065 8697 7324 10393 29945 27338 119504 29882 891 246184 983 55320 996 51400 51434 10133 51433 5347 28227 23291 7486 5982 4218 55355 5883 5884 63943 5983 3161 51451 116028 4659 3364 5520 472 90381 79596 672 675 79866 84126 51512 1111 83990 144715 83695 5810 10111 5932 7979 4361 7156 4172 8454 9156 4173 4683 4174 4175 11073 580 4176 10524 4171 990 641 1763 84515 545 51053 5000 6117 5984 5001 5985 890 8900 6119 6500 5888 23595 6118 23594 81620 80010 4998 5889 4999 6249 5566 8945 23649 5422 2801 5557 5558 5577 5753 3065 1029 595 1017 3326 994 1026 64785 8318 9837 84296 51659 8924 4609 5901 9861 6233 387103 10734 10856 6847 27030 54069 100134934 7316 9662 4438 7840 7514 4439 5578 11064 22994 5537 22995 64326 10213 10388 7283 10733 55505 80321 11339 7534 203068 84057 114791 54433 8021 55722 79858 1454 5706 56979 1453 5707 55651 5708 55125 23626 9814 79991 5709 85378 165918 9985 11190 115106 51773 79441 54921 207 95681 7468 10426 5700 23243 5701 1263 27175 11144 1069 23345 3842 5702 653784 23224 7529 54801 644186 10142 7158 5704 9702 23353 10540 5705 25777 5682 5108 80119 11116 5683 27127 4751 5684 55164 5685 29922 1736 55142 5686 93426 22897 55291 5717 63922 27229 5718 54930 256126 5719 5116 56158 79959 29893 9025 1432 80184 93323 80169 11047 50511 728642 1030 23354 201254 5713 22981 79075 5714 440145 63979 5690 8481 51750 10844 5691 2010 5692 80254 5693 121441 5694 55755 984 7311 5695 10806 10121 7314 55559 8636 11258 80097 3930 5687 84131 5688 4957 5600 5689 6418 9133 140609 91754 10783 23592 4001 1104 27183 6790 25946 3320 7027 1021 1019 894 896 10714 1871 5424 898 5425 1870 57804 51343 6502 3978 1616 9134 1028 1027 546 4149 7029 1869 5925 8970 8331 25836 8337 8243 128312 9126 8334 23244 23047 8335 9493 10735 2033 8370 23063 23383 5885 55766 8968 10274 10112 57060 8341 8342 8347 8348 8290 94239 8345 3013 26277 25913 8340 7013 65057 7014 8338 255626 54386 3021 653604 3018 3017 9663 85236 3014 8349 474382 54145 9656 8317 64900 23175 8467 2932 2810 1452 22822 91768 10776 64151 81876 5861 5862 1032 1031 22933 1163 255919 84930 157570 2029 55844 64689 55732 113130 9918 114799 9700 6683 8615 10000 347688 7443 8556 8548 23397 9798 1719 7153 221496 26271 1859 9232 DEFECTIVE SLC24A4 CAUSES HYPOMINERALIZED AMELOGENESIS IMPERFECTA (AI)%REACTOME%R-HSA-5619055.4 Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) 123041 DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER'S DISEASE MODELS%REACTOME DATABASE ID RELEASE 95%8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 831 2801 5052 84290 356 4001 823 7531 351 993 824 10018 826 1020 994 995 7001 2309 8851 3725 6648 REGULATION OF ENDOGENOUS RETROELEMENTS BY KRAB-ZFP PROTEINS%REACTOME%R-HSA-9843940.1 Regulation of endogenous retroelements by KRAB-ZFP proteins 474382 57459 7700 3065 54145 55422 54815 10793 9422 162655 5928 340252 79862 285676 9869 7562 1107 155054 5931 7329 3066 23468 91661 147686 10155 7576 6613 6940 65251 1108 9219 57504 162967 162963 7581 9112 125893 147658 53615 284306 197320 55729 8970 8331 8337 128312 8334 8335 25799 84911 8370 55766 8968 81931 8341 8342 8347 8348 94239 8345 3013 7695 8340 90075 8338 255626 113835 3021 653604 3018 7767 3017 85236 3014 57693 8349 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME DATABASE ID RELEASE 95%3296482 Defects in vitamin and cofactor metabolism 2694 326625 27249 25974 4594 166785 51293 6948 5826 4552 55788 31 64087 5096 81693 686 5091 56922 3141 5095 8029 4548 Z-DECAY: DEGRADATION OF MATERNAL MRNAS BY ZYGOTICALLY EXPRESSED FACTORS%REACTOME%R-HSA-9820865.1 Z-decay: degradation of maternal mRNAs by zygotically expressed factors 8106 1974 1973 9775 1977 10605 1981 26986 1975 129563 79670 23318 ALPHA-OXIDATION OF PHYTANATE%REACTOME%R-HSA-389599.4 Alpha-oxidation of phytanate 10478 55825 26061 5264 11001 ORC1 REMOVAL FROM CHROMATIN%REACTOME%R-HSA-68949.5 Orc1 removal from chromatin 1017 9861 6233 9978 7316 10213 5706 5707 5708 5709 5700 5701 5702 5704 6502 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 4172 8454 4173 4174 5687 4175 5688 4176 4171 5689 990 84515 5000 5001 890 8900 6500 23595 23594 81620 4998 4999 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 95%426117 Cation-coupled Chloride cotransporters 6560 9990 10723 57468 6557 6558 6559 DEFECTIVE SLC34A1 CAUSES HYPOPHOSPHATEMIC NEPHROLITHIASIS OSTEOPOROSIS 1 (NPHLOP1)%REACTOME DATABASE ID RELEASE 95%5619040 Defective SLC34A1 causes hypophosphatemic nephrolithiasis osteoporosis 1 (NPHLOP1) 6569 RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6790901.6 rRNA modification in the nucleus and cytosol 115939 25926 114049 27340 10436 27341 57647 55623 55226 88745 10199 9136 22984 57050 55272 4839 51077 10607 11056 9724 84135 134430 51118 10885 4809 10528 51504 55505 54433 55651 1736 51602 6194 6208 6187 10171 6201 79050 84916 23160 6203 10813 27042 55127 54555 84128 51202 8602 92856 11103 65083 9277 25879 9790 51096 55813 5822 27292 56902 2091 AMYLOID FIBER FORMATION%REACTOME DATABASE ID RELEASE 95%977225 Amyloid fiber formation 83464 51107 474382 3375 5045 54145 335 337 4057 3339 7045 9027 793 23163 567 6622 10098 81619 54959 6477 5617 26088 325 9627 9445 4069 6653 23621 348 340348 23062 3015 6478 23555 6233 9246 7316 7276 2243 6406 4878 2934 8970 8331 8337 5071 128312 8334 8335 8370 3630 1471 8968 7311 8341 7314 351 8342 8347 8348 8345 3013 8340 8338 4240 255626 3021 653604 3018 3017 102 85236 3014 6288 23385 8239 796 55851 8349 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111931.3 PKA-mediated phosphorylation of CREB 113 114 115 26960 107 108 109 196883 808 5566 5567 5568 5573 5575 5576 5577 111 5613 112 B CELL ACTIVATION%REACTOME DATABASE ID RELEASE 95%983705 B Cell Activation 29760 4793 973 974 3551 6885 640 10125 3710 5295 80228 10892 84433 84876 7220 930 25780 808 118788 9861 2280 4794 6233 933 5966 27071 6786 4067 7316 695 3708 3709 10213 8945 5706 4690 5707 5708 5709 5478 4773 5700 4775 5701 5970 5702 5704 5705 5682 23291 5683 5684 5685 5686 5717 5718 5719 2534 6850 4893 11047 5713 4772 5579 5714 5690 5534 5777 5691 5692 10768 8517 4792 5693 5694 7311 7979 5695 5293 7314 4790 8454 5530 5687 5532 5688 5689 8915 6500 7409 1147 6654 5336 30011 3265 STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME DATABASE ID RELEASE 95%211994 Sterols are 12-hydroxylated by CYP8B1 1582 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%R-HSA-933541.7 TRAF6 mediated IRF7 activation 7706 64135 84282 7186 1387 7189 3442 3441 3661 2033 3440 29110 89122 3452 23586 3451 3449 3448 3447 3446 3445 80143 57506 3444 10010 3443 9641 3665 3456 DEFECTIVE PGM1 CAUSES CDG1T%REACTOME%R-HSA-5609974.5 Defective PGM1 causes CDG1t 5236 RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME%R-HSA-5627083.4 RHO GTPases regulate CFTR trafficking 1080 57120 23433 SIGNALING BY GSK3BETA MUTANTS%REACTOME DATABASE ID RELEASE 95%5339716 Signaling by GSK3beta mutants 5515 5516 5518 1499 5525 5526 8312 2932 5527 324 5528 1452 5529 139285 5519 MINERALOCORTICOID BIOSYNTHESIS%REACTOME%R-HSA-193993.4 Mineralocorticoid biosynthesis 3972 3284 3283 1585 1081 1589 HH MUTANTS ABROGATE LIGAND SECRETION%REACTOME DATABASE ID RELEASE 95%5387390 Hh mutants abrogate ligand secretion 5706 5707 5708 5709 5700 5701 3549 5702 10956 5704 5705 5682 84447 5683 5684 5685 5686 7415 5717 5718 5719 27248 11047 5713 5714 51009 5690 5691 5692 5693 6400 5694 7311 7979 5695 7314 9861 6233 5687 5688 5689 7316 55733 6469 10213 50846 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME DATABASE ID RELEASE 95%1606322 ZBP1(DAI) mediated induction of type I IFNs 3661 29110 147945 8737 8517 4792 7098 4793 23220 28512 81030 3551 4790 5970 4615 28511 11035 4791 1660 1147 148022 INTERLEUKIN-2 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 95%451927 Interleukin-2 family signaling 3561 3716 6776 2185 5295 6655 6772 3562 5296 3559 3558 6464 6850 3636 3932 5290 5291 8503 9846 5777 5293 1437 3563 59067 3560 3581 84868 3635 2885 6774 3578 1439 50615 1438 3568 3718 3601 6654 6775 3567 3600 6777 3717 3965 METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME DATABASE ID RELEASE 95%6806667 Metabolism of fat-soluble vitamins 4035 29967 154807 83875 7274 1645 79001 29914 335 5948 336 26020 375790 337 54884 57016 53630 5406 55937 1208 3339 3949 51109 345 9227 6383 8644 221914 5950 151056 9672 10082 5947 6385 2262 344 6382 2239 7804 4036 348 2719 2817 1109 338 338328 7276 4023 IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME DATABASE ID RELEASE 95%1606341 IRF3 mediated activation of type 1 IFN 3661 29110 147945 23220 81030 NEF MEDIATED CD4 DOWN-REGULATION%REACTOME%R-HSA-167590.5 Nef Mediated CD4 Down-regulation 163 1175 1173 920 51606 160 3932 161 375 ALECTINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717316.3 alectinib-resistant ALK mutants 238 SIGNALING BY TCF7L2 MUTANTS%REACTOME DATABASE ID RELEASE 95%5339700 Signaling by TCF7L2 mutants 1487 6934 1488 ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS%REACTOME DATABASE ID RELEASE 95%9609736 Assembly and cell surface presentation of NMDA receptors 55327 320 116443 26960 116444 64130 8825 88 57576 1742 1741 1740 2906 1739 2905 815 2904 2903 816 4747 2902 817 818 8573 DNA METHYLATION%REACTOME DATABASE ID RELEASE 95%5334118 DNA methylation 474382 54145 29947 8970 8331 8337 128312 8334 8335 8370 29128 55766 8968 8341 8342 8347 8348 94239 8345 3013 1789 8340 1788 1786 8338 255626 3021 653604 3018 3017 85236 3014 8349 H139HFS13* PPM1K CAUSES A MILD VARIANT OF MSUD%REACTOME%R-HSA-9912529.1 H139Hfs13* PPM1K causes a mild variant of MSUD 594 152926 1629 1738 593 DISEASES OF DNA DOUBLE-STRAND BREAK REPAIR%REACTOME%R-HSA-9675136.4 Diseases of DNA Double-Strand Break Repair 7486 5982 5883 5884 5983 116028 3364 472 10635 672 675 84126 83990 144715 83695 5810 7516 10111 5932 7979 4361 7156 5890 9156 5892 4683 11073 580 10524 641 1763 545 6117 5984 5985 6119 79728 5888 6118 80010 5889 DS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%2022923 DS-GAG biosynthesis 10090 63827 29940 1634 51363 92126 633 1464 1462 1463 10675 113189 BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME DATABASE ID RELEASE 95%9025106 Biosynthesis of DPAn-6 SPMs 246 239 DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-HSA-5693606.4 DNA Double Strand Break Response 51588 54145 9656 9682 5599 51035 8924 7157 7341 29086 7329 6233 51720 8467 7316 11200 25 8314 165918 7468 7158 2070 5536 7334 322 2140 8970 472 7336 2139 2138 9025 672 128312 79184 3838 8370 10111 7311 8341 4361 7314 8342 8347 8290 8348 8345 84142 4683 9031 9577 580 8340 10524 255626 3018 3017 85236 3014 23030 8349 PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME%R-HSA-69200.4 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes 9134 5925 1017 898 RUNX2 REGULATES GENES INVOLVED IN CELL MIGRATION%REACTOME DATABASE ID RELEASE 95%8941332 RUNX2 regulates genes involved in cell migration 4322 208 10000 865 3678 207 9358 RESPIRATORY SYNCYTIAL VIRUS (RSV) ATTACHMENT AND ENTRY%REACTOME%R-HSA-9820960.2 Respiratory syncytial virus (RSV) attachment and entry 6382 5045 2239 2719 2817 1956 23643 375790 7099 5868 3480 3339 6383 5869 221914 1524 9672 929 4691 10082 6385 5878 2262 ADIPOGENESIS%REACTOME%R-HSA-9843745.1 Adipogenesis 7040 10498 84498 5928 10025 9968 9969 1959 892 5931 10001 5465 1346 29079 1108 57504 655 5468 9112 1149 5469 64641 63976 7350 23090 3192 1019 5970 896 53615 6517 168544 9862 1879 9314 7124 7480 2033 10974 27332 7026 1052 688 6256 6604 83401 90390 57459 1050 3065 54815 2167 6907 51003 8648 79718 84246 1051 9612 10891 8841 9611 23054 9443 9441 1107 7471 9442 54797 55090 5346 5105 3066 9440 8202 80306 133522 51586 948 9439 23097 6837 219541 23389 55588 9412 400569 9967 81857 9219 9477 4086 112950 4089 80205 3952 85441 10499 96764 1387 6721 9370 1024 4790 51129 4023 9282 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 95%186763 Downstream signal transduction 4690 5335 6776 9564 1399 5295 6772 5296 5156 5921 5781 4893 5290 5291 5159 2889 6778 2886 1398 5155 8440 6774 6714 6654 6777 3265 ESR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 95%8939211 ESR-mediated signaling 55970 10498 54331 3727 4313 4846 2354 59345 1655 2782 3276 10681 8850 8877 2625 1903 3320 5469 1950 1956 7528 5241 200845 2099 1027 5536 5590 8970 8331 8337 8243 9126 128312 4893 2958 8334 2957 8335 8503 2033 10735 8370 55766 5885 8968 10274 4602 51523 340481 8341 1105 8342 5594 57678 55625 8347 5595 7764 8348 1386 94239 7090 8345 3169 3013 5481 9166 8340 9687 3480 858 1509 7033 8338 208 7392 255626 7031 4316 3021 653604 3018 2288 1839 3017 85236 3014 23030 3265 8349 474382 10728 54145 3065 4435 861 865 595 23028 3326 8648 6908 7391 5295 5296 8204 346562 5290 4609 5170 4343 6722 192669 23112 27327 26523 6387 192670 8202 27161 808 57690 5451 2289 8312 7514 2771 6714 2770 2100 5440 5441 2494 2773 23189 2963 6801 4318 2962 5434 5435 207 5436 5437 5438 5439 5430 5431 5432 5433 10499 374 2793 596 1025 2792 2791 1387 904 2790 6667 3838 2788 2787 2786 2785 2784 2783 857 51764 4314 7039 2353 685 127933 10524 255324 2069 2002 10000 2309 5747 94235 3725 HISTAMINE RECEPTORS%REACTOME%R-HSA-390650.4 Histamine receptors 59340 3274 3269 11255 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%425410 Metal ion SLC transporters 7779 9187 254428 1317 23516 64924 169026 27173 55532 7922 283375 57419 9843 6546 84679 6550 6553 389015 6547 6548 6549 283652 10479 285195 23315 6717 808 123041 1356 6543 7781 6556 7780 64116 55630 29986 57181 4891 25800 30061 25769 80024 29985 84102 DEFECTIVE ABCC8 CAN CAUSE HYPO- AND HYPER-GLYCEMIAS%REACTOME%R-HSA-5683177.4 Defective ABCC8 can cause hypo- and hyper-glycemias 6833 3767 DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 95%68952 DNA replication initiation 23649 5422 56655 54107 5557 5558 5426 5427 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%R-HSA-2206285.5 MPS VI - Maroteaux-Lamy syndrome 411 TRANSLESION SYNTHESIS BY REV1%REACTOME%R-HSA-110312.3 Translesion synthesis by REV1 7311 5111 7314 5980 6233 10459 51455 5981 5982 6117 5984 7316 5983 5985 6119 6118 RNA POLYMERASE I TRANSCRIPTION%REACTOME%R-HSA-73864.5 RNA Polymerase I Transcription 474382 57459 3065 54145 54815 54700 5928 6908 10919 51082 1107 7343 5931 3066 9533 11335 8850 5440 284119 5441 4331 1108 1022 9219 25885 2071 57504 2966 9112 2965 2068 5434 5435 64425 5437 7270 79101 2968 2967 10849 53615 404672 902 221830 8970 8331 8932 2648 8337 128312 8334 8335 9014 9015 9013 8370 55766 8968 84172 2074 8341 8342 5595 8347 8348 94239 8345 3013 8340 8338 255626 3021 653604 3018 3017 85236 3014 30834 8349 SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME%R-HSA-8849932.6 Synaptic adhesion-like molecules 5792 2892 10211 2893 2890 1742 57622 1741 57497 79414 2906 78999 1739 2905 5789 10313 2904 2903 2319 2902 5802 SYNTHESIS OF PA%REACTOME%R-HSA-1483166.8 Synthesis of PA 84803 2820 200879 64600 2819 137964 23171 201164 26279 55326 248 150763 30814 5337 5338 81579 56894 56895 22925 8443 5321 79888 84895 57678 253558 10554 374986 254531 8399 51205 100137049 5322 23259 149998 80821 10555 283748 5320 5319 PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME%R-HSA-433692.6 Proton-coupled monocarboxylate transport 6566 23539 9123 682 9194 133418 LINOLEIC ACID (LA) METABOLISM%REACTOME DATABASE ID RELEASE 95%2046105 Linoleic acid (LA) metabolism 60481 3992 64834 2180 9415 215 83401 54898 REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 95%9022692 Regulation of MECP2 expression and activity 3065 25942 5566 6907 3064 79718 9612 8841 9611 4343 2874 192669 23112 27327 26523 3066 192670 814 27161 808 57690 9212 2290 3930 815 816 28996 817 818 SARS-COV INFECTIONS%REACTOME%R-HSA-9679506.7 SARS-CoV Infections 5928 143 5931 2931 56965 83666 84875 79668 54956 54625 79643 51652 1108 91782 23479 2339 92421 4869 5970 3837 26276 11035 7334 27243 128866 10971 29082 5978 25978 51311 2288 7409 84061 11282 7841 57459 29801 25921 253832 10728 51201 3459 55741 3460 1650 11320 3551 51125 4247 51304 100128731 4249 6185 7991 4124 4245 6184 25834 23193 58505 201595 6383 2530 221914 79844 821 11253 5589 9672 10082 51114 746 6385 1603 3703 2262 7341 6382 29108 2239 2719 7329 2817 8767 57506 9978 695 9868 7428 8678 3716 5478 4088 4089 7297 114548 3838 89122 4792 10392 7532 23586 7531 7533 64426 684 7706 84282 6885 7187 7189 2697 348995 9883 6396 129401 9688 10454 57122 9817 23225 64127 4927 23165 55746 55706 23636 4690 9631 7175 8737 9972 11097 23279 8086 23511 53371 8480 79023 79902 10762 64135 53615 5903 6232 2908 7415 5781 8517 30849 208 1147 5289 6654 85437 3688 5170 54106 3717 10284 5094 6632 6850 6628 6634 51128 6633 6636 6635 6637 51284 3718 3554 5336 160 30011 161 9360 6773 163 3615 3614 29760 51185 1312 973 23186 974 3454 10280 5133 23476 59272 25855 10800 5926 10362 51317 1175 1173 1655 7097 7096 9871 9632 7335 9641 3665 10427 10465 1901 57504 9112 6230 6210 6231 6234 6235 6191 22863 2197 6193 6192 6194 51065 140032 6205 6227 6204 6207 6229 6206 6228 1915 6209 6208 6188 6187 6223 6201 6189 6222 6203 6224 6202 3178 6218 6217 3921 3065 3326 3107 3106 3134 3133 2280 6233 3654 7316 7534 203068 8021 5706 3135 207 7529 10802 10484 834 3676 7311 7314 4790 857 63982 203859 2589 7113 6733 476 57101 477 478 5045 53822 53826 53828 9475 8452 338440 480 481 6093 482 483 486 3105 6772 567 64398 3661 340061 29110 3276 55107 81030 5648 81631 7405 80143 55129 50636 2342 3320 196527 57719 5348 5349 121601 5925 2033 3570 8829 6732 861 54815 375790 23028 3656 257397 23118 3339 79760 91662 27072 84818 6607 3442 23339 3441 9908 10146 1107 3440 79833 11218 23765 6441 11311 3452 4153 3066 3451 25929 5479 3449 7555 3448 10207 3447 57617 64601 3446 23367 3445 26762 54960 3444 55823 3443 11123 8487 7284 2932 65082 10610 3456 2810 9111 1452 79685 6483 92359 9636 50628 6482 26007 6484 3605 112744 6487 9219 6480 256435 83737 27090 1514 8819 4780 598 1387 6667 5777 7082 10000 51742 RESISTANCE OF ERBB2 KD MUTANTS TO TESEVATINIB%REACTOME%R-HSA-9665245.2 Resistance of ERBB2 KD mutants to tesevatinib 11140 3320 2064 55914 STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME DATABASE ID RELEASE 95%3249367 STAT6-mediated induction of chemokines 340061 29110 6778 MPS IV - MORQUIO SYNDROME A%REACTOME%R-HSA-2206290.4 MPS IV - Morquio syndrome A 2588 BIOSYNTHESIS OF A2E, IMPLICATED IN RETINAL DEGRADATION%REACTOME DATABASE ID RELEASE 95%2466712 Biosynthesis of A2E, implicated in retinal degradation 222236 MATURATION OF DENV PROTEINS%REACTOME%R-HSA-9918432.1 Maturation of DENV proteins 23478 60559 3839 5611 28972 402569 2923 3840 90701 3841 1650 335 100128731 6185 7991 6184 3309 58505 201595 821 5593 746 1603 3703 7341 10525 7329 6233 7316 7514 3836 8974 54431 283208 51726 5033 10527 8813 3837 811 8818 22937 3838 7311 7314 10965 54344 4836 5034 9789 84061 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME%R-HSA-428890.4 Role of ABL in ROBO-SLIT signaling 10486 10487 23122 23332 9353 25 6091 27 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN PIGMENTATION%REACTOME DATABASE ID RELEASE 95%9824585 Regulation of MITF-M-dependent genes involved in pigmentation 7299 79083 2315 3662 60 6490 1638 1499 51176 4935 26039 4644 5873 8289 54843 25924 7391 6760 7306 1432 6595 6597 6599 57492 6598 7020 9274 9275 6663 5977 6601 208 8193 6603 6602 6605 6604 605 8110 86 ACTIVATION OF AMPK DOWNSTREAM OF NMDARS%REACTOME%R-HSA-9619483.3 Activation of AMPK downstream of NMDARs 51422 10645 5562 5563 5571 5564 5565 808 53632 SELENOAMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 95%2408522 Selenoamino acid metabolism 6152 6155 6154 6157 9349 6156 6159 6158 23521 51121 11224 6164 200916 6166 6122 6165 6124 6168 6123 6167 6169 6125 116832 25873 6160 6161 140801 4736 6130 6133 9045 6230 6232 6132 6210 6176 6231 6135 6234 6134 6235 6137 6191 6136 2197 6193 6171 6192 6170 6194 6173 6128 51065 6129 140032 6142 6205 6227 6141 6144 6204 6143 6207 6229 6146 6147 6206 6228 6181 6139 6138 6209 6208 6188 6187 6223 6201 6189 6222 6203 6224 6202 6218 6217 3921 9061 9060 2058 6233 6175 7296 11185 191 118672 51520 875 1615 22928 3376 51091 7965 9521 51540 9255 6301 1491 27232 60678 5859 4141 4143 3176 79048 5917 3735 4837 7311 SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME DATABASE ID RELEASE 95%8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes 65264 11065 92912 10477 7324 27338 8078 55284 55236 90268 7320 29089 997 7311 7874 7317 7314 7319 7322 6233 3093 7332 7316 7327 7326 7347 8239 7328 7321 54926 PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME%R-HSA-211945.8 Phase I - Functionalization of compounds 23491 1583 1582 1581 1580 405 1576 196 1573 26 5443 1593 6916 1589 1588 1585 66002 2328 80777 284541 5740 112812 2232 1727 126410 1558 1579 2230 1557 57491 1545 10858 1544 113612 1543 8529 5742 1559 1571 1565 6256 10728 3326 8648 217 1594 1592 1591 340665 120227 56603 57834 9971 9049 9915 4051 1577 1553 1584 216 10499 11283 124 126 1066 127 51302 54996 874 29785 285440 1595 13 125 128 2052 130 131 2327 2326 8824 55902 134147 5447 64757 196743 9420 670 314 4128 4129 1549 1548 64816 1555 1551 218 219 1572 84532 1562 54905 4835 8639 TGFBR1 LBD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3656535 TGFBR1 LBD Mutants in Cancer 7046 7048 7040 2280 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME%R-HSA-76009.4 Platelet Aggregation (Plug Formation) 4352 2244 2266 54518 5906 5908 207 7450 2243 11069 7094 1445 10411 10235 10125 9564 5770 6464 6850 5170 2147 1398 150 3690 151 152 3674 2811 5747 2812 6714 2815 2814 6654 2335 7066 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428933.3 SHC-related events triggered by IGF1R 3480 3481 3479 6654 4893 3265 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME DATABASE ID RELEASE 95%157858 Gap junction trafficking and regulation 10052 57165 375519 57369 2702 2701 2700 127534 2709 2707 2706 1759 2705 2703 219770 125111 1601 10804 1173 81025 84694 1785 8218 1212 4646 7082 2697 1213 1211 SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME DATABASE ID RELEASE 95%162699 Synthesis of dolichyl-phosphate mannose 8813 54344 8818 IRAK4 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 95%5603041 IRAK4 deficiency (TLR2 4) 10333 51135 2244 6271 2266 114609 3146 23643 6280 7097 7096 4615 2243 7099 948 6279 695 929 SIGNALING BY NOTCH%REACTOME%R-HSA-157118.7 Signaling by NOTCH 4904 4192 2208 59 5986 10959 4242 487 488 3516 489 79885 8650 2683 83933 5584 100996717 51548 1991 1999 100996763 388677 23509 56983 3002 4851 4853 4854 4855 102 54567 5663 23385 55851 5664 83464 51107 7088 7089 3065 92737 8788 7091 595 1272 113878 1840 4609 4343 192669 23112 27327 26523 192670 27161 57690 5870 9861 6233 9978 3091 7316 55869 10213 7534 5706 5707 5708 5709 4088 207 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 5690 5691 5692 1024 26960 5693 5694 7311 5695 7314 5687 5688 5689 5045 10013 10014 9734 6868 3714 408 6772 409 7157 892 23220 8850 3280 55534 1950 1956 7027 1871 7029 1869 8970 8331 9794 2648 8337 128312 8334 8335 2033 8370 55766 8968 11060 8341 8342 84441 8347 8348 94239 8345 3013 8340 10046 8338 255626 3021 653604 3018 3017 85236 23129 3014 2173 8349 474382 54145 861 6907 79718 51564 9612 8841 9611 23493 3066 9759 23462 2324 6484 6487 22938 83737 1387 28514 182 6400 7979 3955 8454 5087 9148 9787 54492 171558 23286 10402 142678 26508 10460 388585 6500 57534 3725 CTNNB1 S33 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 95%5358747 CTNNB1 S33 mutants aren't phosphorylated 5515 5516 5518 1499 5525 5526 8312 2932 5527 324 5528 1452 5529 139285 5519 P75NTR REGULATES AXONOGENESIS%REACTOME%R-HSA-193697.3 p75NTR regulates axonogenesis 396 4168 4803 4804 387 4099 57142 4974 84894 DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 95%9734009 Defective Intrinsic Pathway for Apoptosis 831 2801 708 5052 84290 1029 356 4001 823 7531 351 993 824 10018 826 1020 994 995 7001 2309 8851 3725 6648 7157 RPIA DEFICIENCY: FAILED CONVERSION OF R5P TO RU5P%REACTOME DATABASE ID RELEASE 95%5659996 RPIA deficiency: failed conversion of R5P to RU5P 22934 DEFECTIVE SLC16A1 CAUSES SYMPTOMATIC DEFICIENCY IN LACTATE TRANSPORT (SDLT)%REACTOME%R-HSA-5619070.4 Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) 6566 682 SIGNALING BY NTRK1 (TRKA)%REACTOME%R-HSA-187037.4 Signaling by NTRK1 (TRKA) 163 4803 5906 6446 1759 7166 6236 2152 3399 4066 8941 1175 8061 1173 3727 1785 7425 3400 2354 1399 10221 4664 4665 1959 1958 3398 3397 23237 1961 116 1960 117 429 5899 25759 6014 6016 135 6300 5603 10126 53358 4914 5900 57498 26052 1398 1108 5335 4893 5978 2033 8660 5594 5595 1386 10818 6774 5604 5598 387 5605 51231 1849 1848 6654 1846 1845 3265 6456 6457 466 4208 5295 7867 5296 6464 5519 5290 5291 6722 3667 5515 5516 5518 9261 5528 6938 673 4209 5898 5607 1020 7529 8851 1432 2889 6197 6196 4915 9252 6195 4205 2353 5600 1213 1211 3726 2002 160 161 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME%R-HSA-422085.5 Synthesis, secretion, and deacylation of Ghrelin 590 23478 60559 3630 28972 90701 3479 43 619373 7941 1395 2688 7349 3952 2641 5122 9789 9314 NEDDYLATION%REACTOME%R-HSA-8951664.7 Neddylation 11091 5929 154881 51088 9616 5931 8835 9306 150726 10537 55208 10072 28952 23142 55336 26094 54939 9655 23038 140825 23369 8945 54951 23363 1154 54165 149951 1161 80344 55827 93611 23113 127247 84259 401036 56929 51514 79791 79016 51122 54876 50717 83987 8451 26043 51665 150684 8533 8816 51666 90864 170622 64708 10116 79269 51397 55884 142686 55527 56995 142685 28991 10987 80067 51676 10980 55666 123879 142689 8883 122416 50813 10920 80204 1642 57542 23014 25793 11275 64410 222235 54850 140456 140458 140459 80028 23194 90135 146330 140460 140461 8878 140462 1026 54620 115290 7704 55958 8139 390594 84961 122769 55175 27252 8453 51130 9861 7323 6233 7322 2034 9903 9978 3091 4738 7316 6921 6923 92369 64344 64326 126433 10213 7428 26259 7347 201456 144699 5706 5707 899 5708 84861 5709 7353 26268 5700 90293 5701 84727 92591 5702 26263 5704 26267 5705 5682 53339 5683 10489 5684 285231 5685 89890 5686 9820 5717 26235 5718 26118 5719 79176 26232 11047 84085 5713 26272 4008 5714 5690 29099 51725 5691 9039 5692 26249 5693 5694 8065 84078 7311 5695 79594 26234 140739 7314 9040 6468 5687 79754 5688 84541 5689 26190 23412 80176 26270 123228 136371 10324 25879 55294 8452 10238 10517 2873 84261 51138 9318 26224 1643 54461 9817 55832 200845 6502 7415 332 139285 114907 7321 23291 4780 672 7979 9021 8454 6500 79728 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3642279 TGFBR2 MSI Frameshift Mutants in Cancer 7048 7040 DEFECTIVE MMACHC CAUSES MAHCC%REACTOME DATABASE ID RELEASE 95%3359474 Defective MMACHC causes MAHCC 25974 RHOBTB2 GTPASE CYCLE%REACTOME%R-HSA-9013418.4 RHOBTB2 GTPase cycle 11140 3320 71 23221 29766 55023 7919 5756 124540 8452 3326 6434 87 10250 27316 9352 3183 11329 908 10574 10576 4646 1627 TAK1-DEPENDENT IKK AND NF-KAPPA-B ACTIVATION%REACTOME%R-HSA-445989.10 TAK1-dependent IKK and NF-kappa-B activation 9684 4793 28512 79671 3551 177 121457 5970 9097 28511 3656 841 257397 6885 23118 80216 7334 11274 7186 7189 7157 8517 4792 10392 7311 3146 7314 4790 351 6233 8767 3654 7335 10454 7316 4791 64127 84166 1147 6285 6288 92610 6283 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 95%428930 Thromboxane signalling through TP receptor 2782 2788 2787 2786 55970 6915 2776 2785 2784 2783 51764 10681 10672 54331 2767 59345 9630 94235 2793 2792 2791 2769 2790 14 DEFECTIVE ABCG8 CAUSES GBD4 AND SITOSTEROLEMIA%REACTOME%R-HSA-5679090.4 Defective ABCG8 causes GBD4 and sitosterolemia 64241 64240 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381038.5 XBP1(S) activates chaperone genes 5611 2673 7094 84447 9695 9820 6464 10130 3068 22872 55062 10954 58477 2137 6745 10525 2135 10113 9114 2931 10897 27230 4000 7466 9797 4189 116138 9570 6818 7709 56005 10106 55033 1663 118 1200 5526 2134 100137049 6734 64061 11015 55738 30827 1639 51726 37 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME DATABASE ID RELEASE 95%2033519 Activated point mutants of FGFR2 2252 27006 2255 2251 8074 2249 2248 2247 2246 2263 8823 8817 26281 2254 PI5P REGULATES TP53 ACETYLATION%REACTOME%R-HSA-6811555.3 PI5P Regulates TP53 Acetylation 2033 8396 5305 5300 79837 3622 90809 5608 7157 ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 95%9034793 Activated NTRK3 signals through PLCG1 5335 4916 4908 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME%R-HSA-168164.6 Toll Like Receptor 3 (TLR3) Cascade 6885 7187 7186 7189 79155 7157 3661 29110 8772 10010 7335 9641 3665 10454 64127 8945 8737 329 5970 841 11035 330 7334 148022 8517 3146 5594 5595 1386 5604 5598 51231 1849 84166 1147 1848 6285 1846 6288 1845 92610 6283 9684 4793 28512 79671 3551 177 121457 5599 28511 3656 257397 23118 1326 5609 466 80216 6416 4208 5601 7867 5602 5606 5519 7098 5515 5516 5518 7323 6233 7322 8767 3654 9261 7316 5528 4791 7321 5608 9097 10133 23291 11274 1432 4792 10392 7311 6197 7314 6196 351 4790 9252 6195 8454 4205 2353 5600 2002 6500 3725 NFE2L2 REGULATES PENTOSE PHOSPHATE PATHWAY GENES%REACTOME%R-HSA-9818028.2 NFE2L2 regulates pentose phosphate pathway genes 2033 7086 4097 6888 5226 4780 2539 1387 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 95%390466 Chaperonin-mediated protein folding 10383 8786 10382 55294 112714 55135 55970 9628 60 7846 84790 10471 5201 5202 6499 84617 5082 11328 54331 2767 10238 10517 59345 26330 10574 8841 84261 347733 10576 2769 7277 7278 7157 22948 63971 2782 26985 26224 79861 81027 2776 54461 10528 5203 10681 5204 8877 10564 898 9134 908 113457 6950 7203 2793 2792 7280 2791 1460 2790 26272 1459 2788 1457 2787 2786 83752 2785 26234 2784 2783 51764 10693 6468 10376 10694 2629 26190 10575 80086 26270 6774 9630 94235 51807 6000 22803 10381 8787 7411 REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS%REACTOME%R-HSA-210747.3 Regulation of gene expression in early pancreatic precursor cells 2255 3651 390874 256297 3175 4825 6928 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73980.5 RNA Polymerase III Transcription Termination 4782 4784 84265 6741 55703 4774 11128 51728 27297 5434 661 5435 9533 10623 5437 171568 55718 10622 10621 51082 5440 5441 4781 ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS%REACTOME%R-HSA-9659787.2 Aberrant regulation of mitotic G1 S transition in cancer due to RB1 defects 7027 1021 595 1019 1017 894 896 1026 1871 898 1870 9134 1028 1027 7029 1869 5925 DEPURINATION%REACTOME DATABASE ID RELEASE 95%73927 Depurination 474382 4350 54145 8970 8331 8337 128312 8334 8335 4968 8370 55766 8341 8342 8347 8290 8348 55247 94239 8345 26277 3013 25913 8340 7013 65057 7014 8338 255626 54386 3018 3017 85236 3014 8349 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%R-HSA-69205.5 G1 S-Specific Transcription 7298 5422 7083 3065 7027 91750 132660 286826 1876 898 983 8318 1875 55957 1874 5928 7029 1869 5933 5934 5111 6241 990 8900 1719 81620 4998 26271 FATTY ACIDS%REACTOME%R-HSA-211935.5 Fatty acids 57834 66002 1565 8529 1553 1580 1549 11283 1555 284541 1572 1573 4051 126410 1579 RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-HSA-5693568.6 Resolution of D-loop Structures through Holliday Junction Intermediates 348654 146956 197342 84464 23514 80198 79008 7486 116028 472 10635 672 675 83990 63979 7516 10111 5932 7517 7979 4361 7156 5890 9156 5892 4683 55732 580 10524 641 1763 79728 5888 80010 5889 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1LW LOSS OF FUNCTION%REACTOME%R-HSA-9918450.1 Defective visual phototransduction due to OPN1LW loss of function 5956 ACTIVATED NTRK2 SIGNALS THROUGH RAS%REACTOME DATABASE ID RELEASE 95%9026519 Activated NTRK2 signals through RAS 4915 4909 627 6654 4893 3265 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%R-HSA-3371599.4 Defective HLCS causes multiple carboxylase deficiency 31 64087 5096 5091 56922 3141 5095 CERITINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 95%9717323 ceritinib-resistant ALK mutants 238 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296072.4 Voltage gated Potassium channels 3750 3748 3749 3741 8514 3742 3743 3744 3745 3746 3747 3751 3752 3754 3755 131096 3756 3757 9196 27012 27133 26251 3790 9132 170850 3784 3785 3786 3787 3788 7881 23416 9312 93107 23415 169522 3737 56479 3738 3739 81033 3736 90134 CASP5 INFLAMMASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 95%9948011 CASP5 inflammasome assembly 838 FMO OXIDISES NUCLEOPHILES%REACTOME%R-HSA-217271.4 FMO oxidises nucleophiles 2327 2326 2328 PROTEIN HYDROXYLATION%REACTOME DATABASE ID RELEASE 95%9629569 Protein hydroxylation 444 2158 6228 91433 100137047 11338 79697 55854 6132 79831 1819 51389 6157 4733 55239 84864 65094 23210 6194 2107 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3645790 TGFBR2 Kinase Domain Mutants in Cancer 7046 7048 7040 PARASITIC INFECTION PATHWAYS%REACTOME DATABASE ID RELEASE 95%9824443 Parasitic Infection Pathways 113 114 718 115 5045 10006 107 108 55970 109 196883 60 5025 5566 5567 5568 10800 2268 9844 54331 6868 3710 59345 4627 5027 2782 64174 7454 7456 10681 1398 719 2778 3708 147179 3709 25 79792 4690 1511 3552 5335 3553 5970 4650 10769 644150 2209 1855 5573 5575 8976 5576 5577 5613 998 1857 1856 5594 4210 5595 3569 10910 4907 953 10451 957 7410 9051 3606 7409 26999 3326 5599 10810 4644 5879 79651 136 9332 2781 346562 2212 63916 29108 71 808 10109 1793 10552 10093 10092 10095 4067 10094 10097 695 10096 2771 3162 2770 4791 2773 10811 2678 2687 1535 10458 51517 55845 7295 114548 917 3586 834 2793 2792 2534 8936 4651 6850 1432 2791 4620 3055 10787 4641 2790 2214 10152 2788 10628 124056 10768 2787 2786 2785 1800 2784 4790 2783 51764 3071 57105 10163 5747 7474 8324 7525 94235 3725 23191 5336 111 112 27035 CARNITINE SYNTHESIS%REACTOME%R-HSA-71262.5 Carnitine synthesis 223 8424 55217 6470 GSD IA%REACTOME%R-HSA-3274531.4 GSD Ia 2538 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 95%210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 2033 84441 8850 3280 10046 4851 9794 390874 2648 22938 3175 1387 50674 6928 3516 55534 SIGNALING BY RAS MUTANTS%REACTOME DATABASE ID RELEASE 95%6802949 Signaling by RAS mutants 673 8826 2244 2266 7414 8844 10256 54518 5894 22866 5906 4140 5908 7450 5037 2243 7094 1445 7529 369 283455 408 409 4893 4296 3845 808 5594 5595 3690 3674 815 6714 5604 816 5605 817 8315 818 5245 2335 3265 3717 NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME DATABASE ID RELEASE 95%9604323 Negative regulation of NOTCH4 signaling 5706 5707 5708 5709 207 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 9861 8454 6233 5687 5688 9978 5689 7316 4855 10460 6500 10213 7534 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-HSA-5693616.6 Presynaptic phase of homologous DNA pairing and strand exchange 7486 5982 5883 5884 5983 116028 3364 472 672 675 84126 1111 83990 144715 83695 5810 7516 10111 5932 7979 4361 7156 5890 9156 5892 4683 11073 580 10524 641 1763 545 6117 5984 5985 6119 5888 6118 80010 5889 TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 (RBL1) AND P130 (RBL2) IN COMPLEX WITH HDAC1%REACTOME DATABASE ID RELEASE 95%1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 3065 5933 7027 5934 91750 132660 4605 286826 983 1875 55957 5928 1874 890 7029 1869 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME%R-HSA-211897.6 Cytochrome P450 - arranged by substrate type 1583 1582 1581 1580 8648 405 1576 196 1573 5443 1594 1592 1591 1593 340665 120227 6916 1589 56603 57834 1588 1585 66002 9971 284541 5740 9915 4051 2232 112812 126410 1558 2230 1579 1557 1545 57491 10858 1544 113612 1543 8529 1559 1577 1553 1584 10499 11283 51302 29785 285440 1595 1571 1565 5447 9420 1549 1548 64816 6256 1555 1551 1572 1562 54905 LGI-ADAM INTERACTIONS%REACTOME DATABASE ID RELEASE 95%5682910 LGI-ADAM interactions 9211 10368 163175 55203 8745 203190 59283 53616 112755 1742 27092 4185 10369 6804 ACYL CHAIN REMODELLING OF PI%REACTOME DATABASE ID RELEASE 95%1482922 Acyl chain remodelling of PI 22925 79143 79887 123745 5321 255189 64600 8399 26279 11145 30814 5322 8605 81579 283748 5320 5319 DEFECTIVE TRANSLOCATION OF RB1 MUTANTS TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%9661070 Defective translocation of RB1 mutants to the nucleus 5925 PYRUVATE METABOLISM%REACTOME%R-HSA-70268.10 Pyruvate metabolism 57546 10873 55066 3939 79018 54994 10296 1737 347411 4289 25874 25852 2954 80232 10048 54704 160287 81889 92483 7416 3948 5166 2739 3945 7311 7314 1738 6233 2875 4200 5162 5163 7316 5164 5165 5091 23409 64795 4199 4750 64777 51660 8050 5160 5161 SIGNALING BY KINASE DOMAIN MUTANTS OF KIT%REACTOME%R-HSA-9669933.2 Signaling by kinase domain mutants of KIT 3815 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 7486 116028 472 10635 672 675 83990 7516 10111 5932 7979 4361 7156 5890 9156 5892 4683 580 10524 641 1763 79728 5888 80010 5889 REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME%R-HSA-9764560.1 Regulation of CDH1 Gene Transcription 474382 2146 7088 3065 54145 23028 6935 5928 8289 387893 5931 6591 3066 116092 3170 7020 94234 93986 55810 6929 23512 687 7750 348262 10009 8726 6938 54737 7291 1488 1487 5925 8970 8331 8337 128312 8334 6667 9314 8335 5315 6597 8370 55766 8968 7490 8341 5594 8342 60436 5595 8347 7764 8348 117581 94239 8345 3013 9839 11171 8340 23411 8338 255626 3021 653604 3018 6615 3017 85236 3014 8349 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%1660661 Sphingolipid de novo biosynthesis 142891 253782 9218 29095 56848 9217 29956 5587 259230 91012 124976 1455 10715 165679 94103 123099 9517 94101 79603 23683 10558 8560 25865 388931 2531 55304 151742 8877 166929 204219 80777 171546 79152 9429 5007 4363 DRUG RESISTANCE OF PDGFR MUTANTS%REACTOME%R-HSA-9674415.3 Drug resistance of PDGFR mutants 5156 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME DATABASE ID RELEASE 95%186712 Regulation of beta-cell development 3375 207 9794 2648 2308 1387 50674 6928 3516 2255 2033 3630 3170 6514 84441 8850 3280 6927 10046 4821 4760 389692 3174 4851 208 222546 10000 3171 3642 3651 390874 22938 256297 2645 3175 4825 5080 55534 SIGNALING BY SCF-KIT%REACTOME%R-HSA-1433557.6 Signaling by SCF-KIT 8651 4318 867 6776 9402 2887 5879 5295 6772 5296 2534 5781 4893 3932 5290 1111 8503 9846 5777 2242 3815 10019 2886 9306 4067 6774 7006 5578 1215 7525 10076 7409 10750 2241 6654 10603 6777 3265 3717 CELL CYCLE CHECKPOINTS%REACTOME%R-HSA-69620.5 Cell Cycle Checkpoints 8945 7334 7336 10971 1029 1017 1026 8318 995 10926 55388 8924 9861 6233 9978 7316 7514 11200 4194 64326 10213 7534 4193 79858 1454 5706 5707 5708 5709 165918 7468 5700 5701 1263 5702 7529 7158 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 9025 1432 11047 5713 5714 5690 5691 5692 5693 5694 7311 5695 7532 7314 7531 7533 84142 5687 5688 5600 9577 5689 9133 51588 993 7465 9088 7157 29086 348995 25946 6396 51720 57122 55746 23279 79023 79902 898 5903 54908 6232 8655 25909 9134 63967 8379 9183 1027 1063 1062 9184 1060 8970 991 151648 55166 128312 79184 1058 79019 151246 8370 9735 57060 23332 8341 79003 8342 55055 8347 81565 8348 51230 22919 8290 348235 5048 8345 23421 220134 57082 8340 57405 51143 255626 147841 4085 64105 401541 10403 3018 3017 85236 3014 54820 80776 701 8349 54821 378708 1781 54145 23122 1780 79172 9656 1778 81930 8317 55920 84643 3796 9793 91687 57551 79682 5905 1783 5501 83540 80152 2491 5519 332 55143 699 11243 3619 140735 5515 11004 5516 5518 9212 25936 11130 64946 79980 10726 5525 5526 55839 2932 5527 2810 5528 1452 5529 51529 7321 8881 64682 25906 11065 8697 7324 10393 29945 27338 119504 29882 891 246184 983 996 51434 51433 5347 23291 7486 5982 5883 5884 5983 116028 3364 472 672 84126 51512 1111 83990 144715 83695 5810 10111 5932 7979 4361 7156 4172 8454 9156 4173 4174 4683 4175 11073 4176 580 4171 10524 990 641 1763 84515 545 6117 5000 5984 5001 5985 890 6119 8900 6500 23595 6118 23594 80010 4998 6249 4999 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME DATABASE ID RELEASE 95%3304349 Loss of Function of SMAD2 3 in Cancer 7046 4087 4088 7048 7040 4089 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 95%176187 Activation of ATR in response to replication stress 993 1017 8317 995 8318 10926 63967 5982 5883 5884 55388 5983 3364 84126 1111 144715 5810 4172 4173 4174 4175 4176 4171 990 84515 545 5000 6117 5001 5984 5985 6119 23595 23594 6118 4998 4999 MPS IV - MORQUIO SYNDROME B (CS DS DEGRADATION)%REACTOME%R-HSA-9953111.1 MPS IV - Morquio syndrome B (CS DS degradation) 2720 FGFR3 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 95%2033514 FGFR3 mutant receptor activation 8823 8074 8817 2249 26281 2247 2246 2261 2254 LOSS OF FUNCTION OF TP53 IN CANCER DUE TO LOSS OF TETRAMERIZATION ABILITY%REACTOME DATABASE ID RELEASE 95%9723905 Loss of function of TP53 in cancer due to loss of tetramerization ability 7157 GSD 0 (MUSCLE)%REACTOME%R-HSA-3828062.5 GSD 0 (muscle) 2992 2997 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 95%181430 Norepinephrine Neurotransmitter Release Cycle 6571 8541 8497 8499 6844 22999 8500 6580 10497 10815 5864 6616 6857 4128 9256 6582 6804 REGULATION OF FZD BY UBIQUITINATION%REACTOME%R-HSA-4641263.4 Regulation of FZD by ubiquitination 8325 9101 7311 59352 7855 7314 55366 8322 343637 340419 4040 54894 6233 8549 8323 284654 4041 84133 89780 84870 7316 RHESUS BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%9037628 Rhesus blood group biosynthesis 6006 6007 DEFECTIVE ALG6 CAUSES CDG-1C%REACTOME DATABASE ID RELEASE 95%4724289 Defective ALG6 causes CDG-1c 29929 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME%R-HSA-6804114.3 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 2033 3276 5933 7027 5934 5111 891 10498 983 995 6790 25946 1874 581 2810 7029 1647 7157 OLEOYL-PHE METABOLISM%REACTOME DATABASE ID RELEASE 95%9673163 Oleoyl-phe metabolism 148811 DEFECTIVE POMT2 CAUSES MDDGA2, MDDGB2 AND MDDGC2%REACTOME DATABASE ID RELEASE 95%5083629 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 29954 10585 1605 MMR%REACTOME%R-HSA-5358508.3 MMR 4292 4436 5111 9156 10714 5424 5395 5425 4437 57804 3978 2956 6117 6119 6118 PKA ACTIVATION%REACTOME DATABASE ID RELEASE 95%163615 PKA activation 113 114 115 26960 107 108 109 196883 808 5566 5567 5568 5573 5575 5576 5577 111 112 ISG15 ANTIVIRAL MECHANISM%REACTOME DATABASE ID RELEASE 95%1169408 ISG15 antiviral mechanism 7706 3839 402569 3840 3841 5300 9775 6772 25820 3661 5610 1977 7318 6233 348995 9883 6396 9246 129401 4734 9688 7316 57122 9636 23225 3836 4927 23165 8678 8021 55746 55706 3716 23636 9631 7175 9972 5335 11097 7324 23279 1981 8086 23511 53371 8480 79023 79902 10762 3837 5903 3434 4600 9470 2317 1982 8672 7334 317649 5495 4599 11274 3838 1974 1973 7311 23586 7314 5595 51191 MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-HSA-166058.5 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 6279 6885 7186 7189 79155 7157 6280 7097 7096 7335 10454 64127 929 8945 114609 59307 11213 5970 841 7334 6271 8517 3146 23643 5594 5595 1386 7099 57162 5604 5598 51231 1849 84166 1147 1848 6285 1846 6288 1845 92610 6283 51295 51135 4214 8651 9684 4793 28512 57161 79671 3551 177 4615 121457 246330 5599 28511 3656 257397 23118 1326 5609 466 80216 6416 4208 5601 7867 5602 5606 5519 5515 5516 5518 6233 8767 948 3654 9261 7316 695 5528 4791 5608 2244 2266 2243 9097 23291 11274 1432 10333 4792 10392 7311 6197 7314 6196 351 4790 9252 6195 8454 4205 2353 5600 2002 6500 3725 AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 95%450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 5706 5707 5708 5709 1981 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 26986 9861 6233 3304 5687 5688 5689 3315 3312 7316 10213 LEUKOTRIENE RECEPTORS%REACTOME%R-HSA-391906.4 Leukotriene receptors 57105 56413 1241 10800 2840 NVP-TAE684-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 95%9717301 NVP-TAE684-resistant ALK mutants 238 CONSTITUTIVE SIGNALING BY EGFRVIII%REACTOME%R-HSA-5637810.3 Constitutive Signaling by EGFRvIII 11140 3320 1950 5335 2549 867 1956 5295 6464 6654 4893 5290 3265 TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS%REACTOME DATABASE ID RELEASE 95%168271 Transport of Ribonucleoproteins into the Host Nucleus 23636 9631 7175 9972 11097 23279 8086 23511 53371 8480 79023 79902 10762 3837 5903 348995 9883 6396 129401 9688 57122 23225 3836 4927 23165 55746 8021 55706 DEFECTIVE SLC22A12 CAUSES RENAL HYPOURICEMIA 1 (RHUC1)%REACTOME%R-HSA-5619071.4 Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) 116085 SYNTHESIS AND PROCESSING OF ENV AND VPU%REACTOME%R-HSA-171286.3 Synthesis and processing of ENV and VPU 5045 FOXO-MEDIATED TRANSCRIPTION OF CELL DEATH GENES%REACTOME%R-HSA-9614657.2 FOXO-mediated transcription of cell death genes 2033 604 10370 356 10018 4303 65018 4800 4801 4802 6794 2309 27113 2308 1387 1649 SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 95%181429 Serotonin Neurotransmitter Release Cycle 6571 8541 8497 8499 6844 22999 8500 10497 10815 5864 6853 6616 6857 8224 6854 9256 6804 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%2122948 Activated NOTCH1 Transmits Signal to the Nucleus 83464 51107 92737 8788 1272 113878 83737 1840 6868 3714 408 409 28514 182 23220 7311 7314 6233 9148 54492 4851 7316 142678 57534 102 8650 54567 5663 23385 55851 5664 CARDIOGENESIS%REACTOME%R-HSA-9733709.1 Cardiogenesis 4086 11091 4089 1499 51176 4208 2648 9421 23493 93649 150572 2627 6722 8320 6862 57057 6910 55897 8861 6899 1482 23462 4303 2626 10524 9464 3670 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME DATABASE ID RELEASE 95%8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 5275 122809 861 865 1514 9021 1513 1515 TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-168898.11 Toll-like Receptor Cascades 121260 1759 6279 6885 1785 671 7187 7186 7189 79155 7157 3661 7184 29110 6280 7097 7096 338 26052 8772 10010 7335 9641 3665 10454 64127 929 79792 8945 114609 59307 8737 11213 329 5970 353376 841 11035 5641 330 7334 5781 148022 6271 8517 3146 23643 5594 5595 30849 1386 7099 57162 51311 10695 1508 1687 5604 5598 51231 1849 84166 5289 1147 1848 6285 1846 6288 1845 92610 6283 51295 51135 4214 7100 8651 9684 4793 28512 57161 79671 3551 177 4615 121457 81793 246330 5599 28511 3656 5775 257397 23118 1326 5609 466 80216 6416 4208 5601 7867 5602 5606 5519 3684 54106 81622 7098 5515 5516 5518 7323 6233 7322 8767 948 3654 9261 3689 7316 695 5528 4791 7321 5608 3929 2244 2266 2243 9097 1520 10133 23291 1514 1513 11274 1432 1515 10333 4792 8411 10392 4064 7311 80231 6197 3663 7314 6196 351 4790 64145 9252 9450 6195 8454 4205 2353 5600 2002 6500 3725 51284 5336 DEFECTIVE ABCB6 CAUSES MCOPCB7%REACTOME%R-HSA-5683371.5 Defective ABCB6 causes MCOPCB7 10058 NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus 4904 83464 51107 1950 1956 3714 28514 182 7311 11060 7314 6233 9148 54492 7316 142678 4854 10460 57534 102 54567 5663 23385 55851 5664 SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 95%446205 Synthesis of GDP-mannose 3098 4351 5372 5373 29926 29925 PD-1 SIGNALING%REACTOME%R-HSA-389948.6 PD-1 signaling 2146 91445 84661 6048 11091 91319 8452 5133 23476 10956 5928 5929 3727 2354 6772 5931 8405 10331 9070 80380 920 8726 8945 3659 1019 5970 7415 58508 8970 8331 10987 25937 4297 5781 8337 8463 128312 8334 8335 2033 8370 55766 8968 8341 8342 8347 8348 94239 8345 3013 8340 8338 255626 6774 3021 653604 3018 3017 85236 3014 84061 8349 474382 54145 1650 595 83439 100128731 1499 6185 7991 51176 6932 7004 6934 6184 7003 5562 7005 5563 58505 201595 5564 5565 467 746 10413 1603 3703 4609 4343 51422 192669 23112 27327 26523 4613 5571 192670 27161 57690 9861 23512 6233 2034 53632 9978 3091 2932 7316 10213 4791 29126 5706 3716 5707 5708 5709 3123 3122 3120 5700 5701 3119 5702 3118 1445 3117 3115 5704 3113 5705 915 5682 5683 916 5684 4751 917 5685 5686 3127 5717 3126 5718 3125 5719 4780 1460 27248 11047 3932 1387 79139 5713 1459 5714 51009 5690 5777 5691 1457 5692 6400 5693 5694 7311 7979 5695 7532 7314 4790 8454 11160 5687 5688 2353 5689 142678 6500 3725 10613 SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 95%391160 Signal regulatory protein family interactions 10326 140885 5777 7305 2533 5747 55423 5781 8935 2185 961 MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME%R-HSA-163282.5 Mitochondrial transcription initiation 7019 64216 5442 NUCLEAR IMPORT OF REV PROTEIN%REACTOME%R-HSA-180746.3 Nuclear import of Rev protein 23636 9631 7175 9972 11097 23279 8086 23511 53371 4869 8480 79023 1104 79902 10762 3837 5903 5901 348995 9883 6396 129401 9688 57122 23225 4927 23165 55746 8021 55706 OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME%R-HSA-190704.3 Oligomerization of connexins into connexons 2697 2706 2705 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME DATABASE ID RELEASE 95%392451 G beta:gamma signalling through PI3Kgamma 55970 207 54331 59345 2793 2792 2791 2790 5170 2788 2782 2787 2786 2785 2784 2783 51764 10681 208 10000 146850 5294 23533 94235 387 CLASSICAL KIR CHANNELS%REACTOME%R-HSA-1296053.4 Classical Kir channels 3768 3770 3761 3759 REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION%REACTOME DATABASE ID RELEASE 95%9617629 Regulation of FOXO transcriptional activity by acetylation 2033 10628 23411 2309 4303 8850 2308 7295 1387 23410 SARS-COV-2 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME%R-HSA-9705677.2 SARS-CoV-2 targets PDZ proteins in cell-cell junction 92359 7082 10207 2697 64398 THE IPAF INFLAMMASOME%REACTOME%R-HSA-844623.2 The IPAF inflammasome 58484 834 ERYTHROPOIETIN ACTIVATES STAT5%REACTOME%R-HSA-9027283.2 Erythropoietin activates STAT5 2056 4067 6776 8660 6777 3717 2057 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 95%983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 3135 2923 3107 3106 10802 811 10484 3309 22863 3105 821 567 22872 3134 3133 30849 9871 64167 6890 9632 6396 51128 6892 51752 6891 10427 5289 8678 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%R-HSA-196299.3 Beta-catenin phosphorylation cascade 5515 5516 5518 1499 23401 5525 10023 5526 8312 2932 5527 324 5528 1452 5529 139285 5519 PTK6 ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 95%8849474 PTK6 Activates STAT3 6774 55620 9021 5753 CHAPERONE MEDIATED AUTOPHAGY%REACTOME DATABASE ID RELEASE 95%9613829 Chaperone Mediated Autophagy 8100 3320 1915 7311 10013 7314 3326 6233 3043 6035 3312 2670 1068 7316 10226 11315 5116 3920 200894 1080 123 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME DATABASE ID RELEASE 95%1839130 Signaling by activated point mutants of FGFR3 8823 8074 8817 2249 26281 2247 2246 2261 2254 REPLICATION OF THE SARS-COV-1 GENOME%REACTOME%R-HSA-9682706.5 Replication of the SARS-CoV-1 genome 85437 5925 7428 1655 NEURONAL SYSTEM%REACTOME%R-HSA-112316.9 Neuronal System 113 114 10052 115 2774 57369 1312 107 783 341359 108 109 196883 6853 5566 5567 5568 84694 27094 1103 27345 3778 3779 28988 10242 2319 22999 6540 18 80331 10815 5864 140679 6616 6857 9424 6529 3775 7915 3751 10089 3752 3754 3755 131096 56659 3756 3757 6511 3758 3770 338567 9196 5573 11141 27012 5575 27133 5576 10021 5577 3780 5613 3782 3783 6506 6505 26251 3776 6507 3777 51305 3790 348980 9132 170850 57657 3784 81539 5330 10211 3785 5331 3786 3787 3788 7881 23236 6512 83795 6539 23416 9312 93107 23415 169522 54407 54207 50801 3737 56479 23229 3738 3739 610 81033 3736 90134 3750 3748 3749 89822 3741 8514 3742 3743 3744 3745 3746 3747 5879 5562 217 5563 5564 5565 5924 6804 51422 2572 5571 2571 127833 53632 3312 5578 4193 6582 590 6571 8541 8497 8499 8500 6580 10497 2793 2792 8224 6854 2791 2790 5582 3838 5579 2788 10645 6844 2787 26960 2786 84254 2785 6197 2784 6196 2783 51764 6195 43 26050 28964 22871 9066 22865 57502 94235 24145 56666 81858 6812 9546 22839 27163 57669 58512 10611 91683 94030 57555 55970 85358 9454 9455 347731 347730 9456 22829 22941 50944 8495 8496 26037 26045 54331 220074 57596 2037 2035 59345 9229 26280 6532 9369 773 4646 774 54413 8573 777 55327 84189 22843 9378 9379 27330 2782 114798 320 781 116443 782 116444 8536 784 785 64130 143425 2892 8825 57030 57576 321 84631 2893 10681 9647 139065 6572 5923 10550 55799 80059 9256 55584 3781 4893 5792 5594 5595 6538 9463 3760 3761 2550 3759 3359 3265 200909 3772 2562 2561 2560 2559 2558 2557 83988 2556 2555 2554 2036 3762 3763 57622 3765 3766 57497 79414 27092 3768 78999 7102 5789 2570 10313 23426 2569 4905 2567 2566 3773 346562 9495 5802 55879 170572 5170 10369 10368 8973 1143 1142 1141 59283 2900 1138 2743 808 1137 1136 88 2742 2891 1135 2890 3084 2741 1134 1742 2901 1741 1740 285242 2906 200959 1146 1739 2905 1145 815 1144 2904 9568 4900 2771 6714 2770 2903 27020 816 89832 4747 9177 2902 8001 817 2899 818 2898 2897 2773 80852 27165 2744 2752 2911 2915 60482 814 6531 23136 4128 10060 3764 6833 3767 160 111 4916 112 9254 APC TRUNCATION MUTANTS HAVE IMPAIRED AXIN BINDING%REACTOME DATABASE ID RELEASE 95%5467337 APC truncation mutants have impaired AXIN binding 5515 5516 5518 5525 5526 8312 2932 5527 324 5528 1452 5529 139285 5519 PI3K AKT SIGNALING%REACTOME%R-HSA-1257604.12 PI3K AKT Signaling 23186 5928 1958 5931 2931 930 1108 57504 9112 5156 5978 1386 3815 1839 7409 57459 4233 572 3065 4615 1026 5879 389541 28956 2308 57521 55004 8649 4343 192669 55615 10670 6009 23112 27327 5305 26523 6591 192670 64121 27161 64223 57690 23396 153129 9861 81847 6233 84335 3654 2475 7249 58528 10542 10325 7316 146850 8658 5294 2100 23533 79837 10213 4193 5706 5707 5708 2064 5709 207 5700 5701 5702 5728 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 3164 1460 11047 5713 1459 5714 23252 5690 5691 1457 5692 5693 5694 7311 5293 5695 7314 4303 5687 5688 5689 331 842 79109 2146 90865 9173 6446 10014 5371 940 80351 7189 7157 80243 7874 118788 8975 23608 23035 5987 4734 941 2444 942 2122 1822 84232 5880 23239 8394 8726 6199 7101 8395 50852 8870 57167 253260 5468 1950 1956 53615 2099 1027 5781 27006 8503 117145 3630 2549 10273 5159 11060 8660 9542 10718 145957 5594 5595 10818 208 3643 8817 26281 6615 391 9965 1147 2254 2252 51135 2251 8074 54815 2249 23028 2248 2247 57761 2246 2323 2322 152831 8823 51564 5295 5296 8841 2264 5519 5290 8535 5291 5170 6045 2255 1107 9846 3667 648 6015 23466 5515 3066 5516 1912 5518 1911 23512 3084 80012 57332 84733 5525 5526 2932 5527 5528 5529 6714 9219 6801 8396 374 2534 3932 3082 7979 4915 4909 627 7039 685 5155 255324 2069 10000 2309 3725 4916 4908 PYROPTOSIS%REACTOME DATABASE ID RELEASE 95%5620971 Pyroptosis 91782 3552 92421 8626 3553 1991 837 838 581 3002 834 27243 128866 29082 7157 25978 3146 3606 578 79643 1687 51652 836 54205 3660 79792 3659 ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME DATABASE ID RELEASE 95%111452 Activation and oligomerization of BAK protein 578 637 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 95%110381 Resolution of AP sites via the single-nucleotide replacement pathway 7515 5423 3980 328 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 95%1614558 Degradation of cysteine and homocysteine 339896 100131187 51380 1468 1036 6821 4357 84890 2326 2806 1491 7263 25828 23474 58472 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 95%420092 Glucagon-type ligand receptors 2695 55970 2692 2691 9340 2740 7433 6344 7432 6343 7434 2696 54331 59345 2793 2792 2642 2791 2641 2790 116 2788 117 2782 2787 2786 2785 2784 2783 51764 10681 2778 94235 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME%R-HSA-8866911.3 TFAP2 (AP-2) family regulates transcription of cell cycle factors 7022 10765 7020 1026 4609 DEFECTIVE SLC7A9 CAUSES CYSTINURIA (CSNU)%REACTOME DATABASE ID RELEASE 95%5660883 Defective SLC7A9 causes cystinuria (CSNU) 11136 6519 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%R-HSA-2151209.2 Activation of PPARGC1A (PGC-1alpha) by phosphorylation 51422 5563 5571 5564 6300 5565 10891 1432 53632 5600 RAC1 GTPASE CYCLE%REACTOME%R-HSA-9013149.2 RAC1 GTPase cycle 11135 1969 10006 55914 55200 23616 10928 57636 115557 26030 80243 79658 83478 7454 7456 1124 115703 139818 201176 10788 57514 9901 64333 57679 116985 147179 57480 117289 57522 3895 9912 50855 51306 8826 9411 50619 221178 58504 11113 257106 10144 1123 23526 5063 4650 57144 644150 393 5585 396 5586 5337 5338 9938 51291 8976 85440 752 8476 81704 8503 998 23348 9855 7204 9732 57569 23580 10395 128272 57580 10160 25894 26230 57572 11188 1894 10451 128239 7410 56924 84904 23380 23370 25791 94134 9826 7409 81624 26999 22899 6654 50649 8997 7984 29 8874 64857 84144 23263 9639 10672 10810 80005 5879 9459 4168 7074 5295 6655 5296 3688 5924 5290 55004 1795 1794 1793 152273 8773 50508 7444 6510 2909 9743 57584 392 9341 394 5062 1536 10811 397 1535 10458 55843 10979 9815 7879 55845 4688 4689 10298 10652 9710 81839 23092 55971 143872 347902 4810 55619 8936 10787 27 10152 64411 124056 2010 23344 182 143098 29127 4983 613 857 3930 55789 51347 3071 4162 7112 7037 5058 10163 28964 80728 23191 653361 23592 23075 116984 55114 27035 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 95%111367 SLBP independent Processing of Histone Pre-mRNAs 4686 6634 84967 134353 6636 6635 25888 6628 6637 22916 RNA POLYMERASE II TRANSCRIPTION%REACTOME%R-HSA-73857.7 RNA Polymerase II Transcription 5915 5916 146713 143686 84661 341359 3977 11091 63970 349075 2660 163049 1327 163051 4839 5928 5929 163050 654254 900 901 51755 340252 1329 905 30832 65243 285676 4850 1340 79891 3516 4848 2669 1337 4849 79898 5931 5933 5934 1339 4605 23619 1351 65018 1350 9070 100287226 1349 79885 1347 388536 1346 1345 55215 10308 124411 10781 10780 4852 10782 65251 1108 162966 162967 162963 1121 100289635 22974 388569 83933 388566 388567 4869 5970 388561 3549 284309 10769 125965 284307 284306 400720 58500 10520 4878 10765 58508 3562 3559 3558 1378 147741 27166 253639 10971 5978 5979 284370 115509 90233 29117 4298 6830 1392 57677 27125 3329 55840 4300 57678 10018 3569 85403 1386 55677 79230 339327 339559 146434 26053 124446 353274 6601 6603 6602 6605 158431 6604 57209 91584 7710 57693 387032 613227 27153 27154 57459 133383 7700 4435 4436 219749 10370 6872 5300 6874 6873 220992 995 51003 5775 7712 442319 7711 79813 79818 10135 4208 10138 266743 6880 6883 4221 6882 6884 148254 4697 51499 7341 7022 55615 79047 6875 7021 6878 83741 5305 51741 8812 6877 7329 339488 6879 7020 5308 284252 90827 7728 2290 7323 23429 7743 148266 148268 80818 9978 2289 342926 23660 56950 6921 55869 6923 7733 54778 11200 79837 5440 7738 8732 6648 5441 9915 4331 23439 8731 730087 1022 7752 7994 2071 6662 2966 6829 7753 2064 2965 2063 2963 441234 2962 54541 2068 5434 55634 5435 51276 5436 353088 5437 7745 5438 56729 5439 5325 6657 2968 7988 2967 7748 404672 5430 136051 5431 138474 5432 10127 5433 7761 902 7760 91975 7762 8851 114026 3164 339500 4004 4488 1460 100129543 7755 4005 1459 5579 7757 55888 1457 7770 8861 219578 7771 7532 5111 7531 7773 7533 8621 90874 162972 23410 161882 148213 23411 3174 148203 51058 196528 148206 7525 5588 7767 55659 7766 7769 55657 7768 6696 5366 730291 126231 55663 579 55422 8626 6446 10794 10793 10795 7539 5371 7552 7551 9975 285267 9734 285268 7556 581 255403 79862 9968 9969 7549 57615 90649 100131827 7561 129685 7157 7562 7565 122809 7567 7566 4292 355 356 7559 9739 8409 6241 94115 7571 5395 7574 9997 7576 29959 51412 7568 80196 54925 8431 7582 7101 25 7587 6498 7586 6497 6258 253260 7581 84108 9757 8427 7594 7596 9534 8445 7592 126382 142 84333 199777 53615 9540 7122 4091 23368 4094 85456 2908 197320 84124 54715 5196 9794 9310 8463 6046 9314 64769 25799 1820 440519 440515 10273 54971 9337 162239 7159 181 9572 51230 90809 54989 152687 55835 10046 8013 79370 8493 7161 170960 57343 57103 125919 147948 147949 9358 170959 26048 55170 80108 90390 80110 221044 83860 9125 6097 342132 285971 7181 7182 6096 6095 1876 144455 1875 1874 26013 282890 344787 9377 8289 92595 55193 10919 27113 80139 168417 2737 5519 1647 332 2736 79175 133746 6722 93474 84527 4929 387893 84765 58484 5515 57154 83667 5516 3845 5518 2516 9212 133522 9167 5451 121340 6621 58491 58492 6619 1437 1436 7702 147923 6618 27300 10302 59348 5527 6617 147929 340385 8089 7422 112858 8085 84775 3622 2539 2538 27165 2744 8178 22916 25920 4686 51224 6924 7936 6827 6749 9150 6917 1025 51497 7469 11198 904 28514 182 3172 8454 890 8900 6500 5566 7222 4851 4853 4854 4855 2645 7919 5562 5563 6794 7248 5564 5565 389541 28956 57521 55004 8649 51422 10670 6009 5494 5571 64121 64223 153129 53632 2475 7249 58528 10542 10325 857 3930 7040 55240 23168 79577 80349 123169 9646 3674 3678 54623 5054 8535 6045 1107 83746 648 6015 3066 23468 9759 1912 1911 23512 23314 80012 57332 84733 7703 8312 2932 2821 1387 6667 814 627 7039 2353 10000 2309 3725 367 4194 4193 4086 4087 4088 4089 9099 5728 64750 4092 4303 8239 86 6881 7874 1643 8850 2625 7528 51616 2099 84967 134353 65123 57508 80789 26173 55726 5452 55756 64859 2648 26512 5781 4287 23248 25896 80237 79035 79664 3630 29101 22936 81556 55656 79871 23379 2593 54973 5594 92105 5595 51808 55174 57117 55197 84524 58490 9984 81608 208 57187 10898 84324 23283 84321 9877 55339 1479 26097 1478 1477 8563 8683 11051 9775 5770 55110 5170 9785 10978 199746 53981 808 84248 2891 8106 51692 815 2904 6714 51213 2903 816 10189 817 22938 818 51529 7321 8881 64682 51585 25906 11065 8697 7324 10393 29945 27338 119504 29882 891 246184 983 996 51434 51593 51433 7486 79228 5982 5883 5884 5983 116028 3364 472 672 84126 1111 83990 144715 83695 5810 51362 10111 5932 7979 4361 6628 7156 9156 5892 4683 11073 580 10524 641 6634 1763 545 6117 6636 5984 5985 6635 6119 84271 5888 6637 6118 80010 80145 4904 10914 10921 11338 29894 4116 6430 7884 6432 6431 22794 6427 6426 9939 6429 10212 6428 8189 65109 9295 10569 7307 2961 2960 2959 2958 2957 3815 4233 3065 25942 1029 595 83439 1017 1026 1499 51176 25904 6932 100506658 6934 168374 5816 6908 29028 1051 10419 284459 10891 90317 155061 10650 2308 10413 121274 1649 55571 4609 54487 4343 284443 192669 6910 23112 155054 27327 90589 2572 26523 147694 2571 192670 1482 27161 80778 57690 246175 6929 9861 147686 6233 147687 90338 3654 100129842 4986 4988 64065 22869 90576 7316 90333 7514 6940 2100 285349 10213 1493 353355 81856 7534 1490 81857 5608 6938 5706 100131980 5707 79788 5708 283337 4512 5709 4513 4514 22835 3683 207 4773 5700 1263 5701 1020 114787 5702 80317 7529 146540 84914 5704 84924 5705 57547 5682 2104 5683 57541 5684 2103 5685 27287 5686 2101 55367 5717 834 5718 835 5719 3676 839 1432 90594 6720 11047 1030 90592 5713 84911 5714 146542 5690 10628 5691 80314 5692 1024 5693 843 5694 604 7311 847 5695 4778 7314 4790 440077 84701 3458 1278 5687 1277 5688 5600 5875 5876 5689 4322 56242 57573 147657 57336 440073 10848 864 57335 317 79109 50943 54205 6750 3486 3484 23327 199704 632 2146 5045 389114 51123 7832 10013 637 84289 639 10014 10498 11105 10250 162655 146198 117608 640 405 4336 6515 406 10025 23309 7862 79869 6772 5443 7621 2177 2176 1081 650 892 51385 171392 7633 148156 3276 665 341947 79943 7626 7625 10001 11335 7627 3280 6790 25946 5465 126375 374900 55762 79973 79733 5457 8726 5458 7638 348327 7652 23774 29079 57711 55534 5467 5468 5469 55778 10224 8738 25925 1956 5241 7027 1021 91875 1019 7421 894 163732 896 221785 374928 898 200845 148103 3064 51343 6502 694 79755 1616 54457 9134 55786 1027 79759 4149 140612 7029 158399 1869 10432 5925 8970 7673 25937 8331 169270 4297 463 8337 128312 79744 9862 8334 6595 8335 6597 619279 2033 6599 8370 6598 2624 55766 30818 8968 728957 57060 4602 94241 7913 84449 8341 117584 8342 84441 8347 7678 8348 117581 94239 8784 8345 3013 7692 7695 7694 8340 5275 7697 7699 8338 163227 255626 163223 6256 79088 3021 84676 653604 28984 3018 84436 3017 84671 8794 85236 3014 8795 8550 6886 54807 6688 8793 8349 8797 5914 163255 474382 23269 59269 54811 54145 861 55900 865 54815 5052 9656 6257 9891 8317 11059 80095 6907 9422 7001 10172 7004 79718 9668 7003 7005 201514 84246 7376 9612 51564 94039 5079 23019 8841 9611 115196 50484 23493 51333 9443 9441 126070 9442 2874 7025 26974 65988 348 23466 25888 5105 9440 728927 23460 51586 23462 10398 9439 10397 10155 286075 126068 374879 127396 2811 2810 51592 55713 10168 9464 114907 84838 26152 26155 163081 9219 374655 7296 9477 7057 112950 8148 57472 7291 57474 83737 91120 7050 7295 169841 83744 163071 390927 147837 1749 7068 8396 7067 1998 1514 204851 1997 1513 84626 80264 1750 29883 1515 26149 63934 57492 163087 79027 144348 7082 9021 3958 2623 60436 84883 4800 4801 4802 2626 90075 3726 2877 84874 84870 80032 113835 93134 199692 163059 23067 9282 28996 92285 92283 256051 TAMATINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9703009 tamatinib-resistant FLT3 mutants 2322 APOPTOSIS%REACTOME DATABASE ID RELEASE 95%109581 Apoptosis 5366 637 8626 4001 7431 3024 3009 3008 3007 6093 3006 3005 581 1630 7186 7157 355 79658 356 8772 23604 118 51765 28988 90427 3836 929 79792 8428 9414 8737 57099 2339 329 708 7027 6709 10059 353376 3837 841 1828 8655 1832 23368 63967 1830 90249 26060 2934 3002 7029 1613 1869 1612 5533 10134 148022 10971 5317 22900 5534 55075 9500 660 3148 3146 8717 23643 7159 2620 5594 10018 5595 5339 7099 219699 8743 4137 1677 208 1676 7161 578 51074 6774 115209 1687 4976 4836 8795 8797 572 1029 5599 1499 100506658 22985 27113 6304 999 140735 5580 9861 6233 7316 324 2810 10213 7534 5062 5706 5707 5708 5709 207 5700 5701 5702 7529 5704 5705 5682 5683 5684 5685 5686 5717 1829 5718 596 5719 839 598 11047 5713 5714 5690 5691 5692 5693 5694 7082 7311 7979 5695 7532 7314 7531 7533 5687 5688 5689 10000 5747 331 840 842 317 5588 836 54205 56616 SOS-MEDIATED SIGNALLING%REACTOME%R-HSA-112412.5 SOS-mediated signalling 3667 8660 6654 4893 3265 DEFECTIVE CYP2U1 CAUSES SPG56%REACTOME DATABASE ID RELEASE 95%5579011 Defective CYP2U1 causes SPG56 113612 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME DATABASE ID RELEASE 95%1236973 Cross-presentation of particulate exogenous antigens (phagosomes) 1536 3693 3685 1535 653361 4688 4689 948 INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME DATABASE ID RELEASE 95%6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 10618 11127 4074 56894 10959 5049 8729 5321 6811 8398 378 832 26286 9342 8655 9183 84364 1062 1315 9493 10112 9554 9570 5048 26958 9585 8774 8775 51143 27128 23046 55860 24137 51164 11015 57589 55738 10139 830 26153 143187 55605 10671 636 1639 60592 23299 93661 22920 55850 84316 84516 10945 400 1781 63908 51014 1780 57511 55614 146909 1778 8674 81930 8677 8675 84643 339122 55582 23423 3796 23303 4124 250 372 51542 84342 91949 7110 4121 1783 10226 4905 4122 381 5050 9371 221458 51272 662 1523 57134 547 10244 9648 9527 23647 9267 11311 140735 9265 22836 9266 11004 55083 3798 22796 3799 79571 5870 2590 9382 51560 25782 347517 113220 3797 3832 10972 3833 3834 6836 3835 64837 90990 22931 9950 51209 25839 9276 9712 89953 285643 9341 147700 90196 9367 10228 375 122830 11316 83548 3831 23095 10749 27333 10905 2803 60561 60560 10466 9827 3482 9321 22818 22930 6293 10652 2800 1314 10540 124602 54732 56992 54734 51226 83452 738 53407 64147 829 27314 22820 377 55275 51594 11014 9609 81876 5861 29127 10121 11258 2589 HS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%2022928 HS-GAG biosynthesis 9348 64579 64711 375790 2131 3340 90161 222537 26035 9957 3339 9955 9956 8509 6383 221914 9653 266722 9672 10082 11046 6385 9953 9951 2262 6382 9394 2239 2137 2135 2719 2817 RUNX3 REGULATES RUNX1-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%8951911 RUNX3 regulates RUNX1-mediated transcription 865 864 REGULATION OF CDH11 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 95%9759475 Regulation of CDH11 Expression and Function 1499 3728 6667 4343 192669 23112 27327 26523 192670 27161 57690 2294 56978 9839 8728 1495 64403 27319 80332 1006 26508 1500 51129 3224 3609 6615 1009 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME%R-HSA-168176.3 Toll Like Receptor 5 (TLR5) Cascade 51295 51135 4214 7100 9684 4793 28512 57161 79671 3551 177 4615 121457 81793 246330 5599 28511 3656 257397 6885 23118 1326 5609 466 80216 6416 4208 5601 7867 5602 5606 5519 7186 7189 79155 7157 5515 5516 5518 6233 8767 9261 3654 7335 10454 7316 5528 4791 64127 8945 5608 5970 9097 841 23291 7334 11274 1432 8517 4792 10392 7311 3146 6197 7314 6196 351 5594 4790 5595 9252 8454 6195 1386 4205 2353 5600 57162 2002 5598 6500 5604 3725 51231 1849 84166 1147 1848 6285 1846 6288 1845 92610 6283 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME DATABASE ID RELEASE 95%1793185 Chondroitin sulfate dermatan sulfate metabolism 10090 29940 51363 92126 22856 337876 55501 50515 55790 54480 166012 79586 55454 56548 1462 9469 2990 23553 3373 112937 8372 113189 3074 3073 63827 1634 3425 79411 411 2720 3423 633 1464 89944 1463 10675 DEFECTIVE MPI CAUSES CDG-1B%REACTOME DATABASE ID RELEASE 95%4043916 Defective MPI causes CDG-1b 4351 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME%R-HSA-418038.3 Nucleotide-like (purinergic) receptors 2846 10161 135 5028 5030 53829 140 5029 64805 134 9934 27334 136 5031 5032 2840 MITOPHAGY%REACTOME DATABASE ID RELEASE 95%5205647 Mitophagy 10452 8878 10133 100188893 7334 7417 7416 7419 401505 5071 1460 51001 1459 56993 29110 1457 7311 7314 9804 54543 7323 7322 6233 65018 9927 81631 9140 55669 8408 9474 7335 79065 84557 7332 139341 7316 9868 NPAS4 REGULATES EXPRESSION OF TARGET GENES%REACTOME%R-HSA-9768919.3 NPAS4 regulates expression of target genes 2669 5979 146713 3630 341359 5594 5595 1020 627 2353 10769 405 406 10135 440073 7514 8851 266743 9915 1387 4193 DEFECTIVE ABCB4 CAUSES PFIC3, ICP3 AND GBD1%REACTOME%R-HSA-5678771.4 Defective ABCB4 causes PFIC3, ICP3 and GBD1 5244 INTERLEUKIN-9 SIGNALING%REACTOME DATABASE ID RELEASE 95%8985947 Interleukin-9 signaling 3716 3561 3581 6776 3578 6774 6772 3718 6777 SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 95%5654688 SHC-mediated cascade:FGFR1 27006 2255 2251 8074 2249 2248 2247 2246 26281 6654 4893 2254 3265 DEFECTIVE ABCA12 CAUSES ARCI4B%REACTOME%R-HSA-5682294.4 Defective ABCA12 causes ARCI4B 26154 SIGNAL AMPLIFICATION%REACTOME%R-HSA-392518.3 Signal amplification 55970 5028 10672 54331 2767 59345 2793 2792 1432 346562 2791 2769 2790 14 2788 2782 2787 5321 2786 6915 2785 2776 2784 2783 51764 10681 64805 2771 2770 9630 94235 2773 DEFECTIVE VWF CLEAVAGE BY ADAMTS13 VARIANT%REACTOME%R-HSA-9845621.1 Defective VWF cleavage by ADAMTS13 variant 7450 11093 MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS%REACTOME DATABASE ID RELEASE 95%9022699 MECP2 regulates neuronal receptors and channels 4233 7222 3065 25942 3066 2891 114787 5775 2289 4986 4988 6515 2904 2903 5770 PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME%R-HSA-964827.3 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 10905 4121 57134 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 95%73854 RNA Polymerase I Promoter Clearance 474382 57459 3065 54145 54815 54700 5928 6908 10919 51082 1107 7343 5931 3066 9533 11335 8850 5440 5441 4331 1108 1022 9219 25885 2071 57504 2966 9112 2965 2068 5434 5435 64425 5437 7270 79101 2968 2967 10849 53615 404672 902 221830 8970 8331 8932 2648 8337 128312 8334 8335 9014 9015 9013 8370 55766 8968 84172 2074 8341 8342 5595 8347 8348 94239 8345 3013 8340 8338 255626 3021 653604 3018 3017 85236 3014 30834 8349 SIGNALING BY ERYTHROPOIETIN%REACTOME DATABASE ID RELEASE 95%9006335 Signaling by Erythropoietin 5335 2549 6776 2889 8660 5293 2057 2056 4067 5294 5295 1399 23533 7409 6464 6654 4893 5290 5336 5291 6777 3265 3717 RESPONSE OF MTB TO PHAGOCYTOSIS%REACTOME%R-HSA-9637690.3 Response of Mtb to phagocytosis 5230 1511 2931 51606 7311 7314 5594 7879 5595 9146 6233 2023 11151 3837 26276 57674 5868 5987 7316 4843 80824 6421 3836 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME%R-HSA-77288.4 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 3030 1666 1632 33 34 3032 GABA RECEPTOR ACTIVATION%REACTOME%R-HSA-977443.7 GABA receptor activation 113 114 3772 115 2562 2561 2774 2560 107 2559 108 55970 2558 109 2557 196883 2556 2555 2554 3762 3763 3765 3766 3768 54331 2570 2569 59345 2567 2566 3773 346562 55879 2782 10681 200959 9568 2771 2770 27020 2773 2793 2792 2791 2790 2788 2787 2786 2785 2784 2783 51764 94235 23229 3760 3761 2550 3759 111 112 DEFECTIVE DPM2 CAUSES CDG-1U%REACTOME%R-HSA-4719377.4 Defective DPM2 causes CDG-1u 8813 54344 8818 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (DUODENUM)%REACTOME DATABASE ID RELEASE 95%5655799 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) 9843 30061 DEFECTIVE SLC5A5 CAUSES THYROID DYSHORMONOGENESIS 1 (TDH1)%REACTOME%R-HSA-5619096.4 Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) 6528 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 95%381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 8826 114 55970 5906 3745 5566 2740 5567 3747 11069 5568 10411 54331 3710 59345 2793 2792 5573 5575 2791 2641 5576 9495 5577 2790 26251 2788 2782 2787 2786 3790 2785 2784 2783 51764 10681 2778 3708 3709 94235 111 112 ADRENOCEPTORS%REACTOME%R-HSA-390696.5 Adrenoceptors 151 152 154 153 155 146 147 148 150 NFE2L2 REGULATING INFLAMMATION ASSOCIATED GENES%REACTOME%R-HSA-9818026.1 NFE2L2 regulating inflammation associated genes 2033 6347 4780 1387 7975 FASTK FAMILY PROTEINS REGULATE PROCESSING AND STABILITY OF MITOCHONDRIAL RNAS%REACTOME DATABASE ID RELEASE 95%9837092 FASTK family proteins regulate processing and stability of mitochondrial RNAs 9238 60493 22868 PREDNISONE ADME%REACTOME DATABASE ID RELEASE 95%9757110 Prednisone ADME 54659 1576 1645 5243 866 213 3291 3290 7364 7367 TICAM1,TRAF6-DEPENDENT INDUCTION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 95%9014325 TICAM1,TRAF6-dependent induction of TAK1 complex 6885 23118 10454 7098 7316 7311 7314 6233 7189 148022 257397 SNRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 95%191859 snRNP Assembly 10419 79760 6607 79833 11218 25929 54960 348995 9883 6396 129401 8487 9688 57122 50628 23225 4927 23165 8021 55746 55706 23636 9631 7175 9972 11097 23279 8086 23511 53371 8480 79023 79902 10762 5903 22916 4686 96764 6632 6628 51808 6634 6633 6636 6635 10073 1207 6637 79084 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME DATABASE ID RELEASE 95%170834 Signaling by TGF-beta Receptor Complex 4904 3693 5045 3694 3065 7046 7048 7040 9110 1875 1874 51377 23645 5054 9612 5501 3688 905 9611 8516 4221 4609 892 7049 8812 5494 5933 57154 7323 2280 6233 4738 7316 7514 5500 51592 54778 6498 22938 23439 6497 50855 7321 4087 867 4088 7027 4089 7050 142 5499 64750 4092 7029 50848 9958 5590 1025 57530 25937 56288 904 6667 1030 4052 4054 2033 1024 10273 7311 7314 5594 60436 5595 9040 25805 56937 1278 3696 11171 3690 8425 3726 23370 3685 387 7043 7042 8239 23327 TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME DATABASE ID RELEASE 95%432030 Transport of glycerol from adipocytes to the liver by Aquaporins 364 366 ACTIVATION OF C3 AND C5%REACTOME DATABASE ID RELEASE 95%174577 Activation of C3 and C5 629 717 718 721 727 VARIANT SLC6A14 MAY CONFER SUSCEPTIBILITY TOWARDS OBESITY%REACTOME%R-HSA-5619094.4 Variant SLC6A14 may confer susceptibility towards obesity 11254 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME DATABASE ID RELEASE 95%2142688 Synthesis of 5-eicosatetraenoic acids 2876 2877 5445 5446 5444 2879 240 4056 241 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%R-HSA-4608870.3 Asymmetric localization of PCP proteins 144165 8321 8325 57154 9861 6233 7316 10213 50855 57216 5706 5707 5708 5709 5700 5701 5702 5704 64750 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 5690 5691 5692 5693 1856 5694 7976 7311 7855 7979 5695 7314 8322 23513 5687 5688 5689 2535 7474 8324 AXON GUIDANCE%REACTOME%R-HSA-422475.8 Axon guidance 1759 8218 4313 10570 1809 56896 1400 1808 53358 26052 6386 6709 90249 1605 5979 7204 23365 219699 10451 7410 25791 9826 5598 91584 102 5663 8997 23385 55851 6453 5664 83464 8874 51107 5879 6383 7074 6655 2817 5362 10371 6478 2242 23396 8453 6237 55558 9978 4067 6921 6923 6175 2064 4318 23032 1072 5788 4478 8851 5306 1460 1459 1457 8861 5293 6197 6196 9252 6195 3672 7525 5588 3670 7305 85358 60 64283 782 784 785 27289 6711 23114 25 4690 6232 5781 4893 5361 5364 8503 998 9855 2549 23332 8660 5594 5595 10818 23380 8440 24137 387 388 6654 389 23129 3265 23122 2887 5216 5217 9775 5295 3688 5296 55110 6464 5290 5291 9846 51466 71 6387 2886 1742 1741 1793 1739 7852 2904 6714 2902 285643 286 4897 6900 55740 8828 10048 7094 22916 4686 2534 4651 7979 1213 1211 7436 2668 2676 2675 2674 776 10752 160 30011 285220 161 4753 4756 7430 163 6708 57556 100133941 2596 6710 783 5623 6712 971 5962 148738 5909 137970 5566 64096 5567 4440 10921 57698 5568 5649 2045 2044 2043 10487 4628 1175 2042 79784 1173 2041 4116 4629 5786 10507 116986 1785 64218 3984 775 3985 2046 103910 4637 779 4627 56956 56963 22794 23767 8986 6324 6477 6323 11313 1286 89884 1285 54209 7220 6331 256076 6330 7222 9939 8633 7224 9723 7223 6332 5365 7225 6335 6334 214 6326 8506 131873 6328 6327 6329 6586 1293 6585 1292 3199 1291 57731 6336 23053 11280 57113 7408 59277 220164 55800 65109 8650 1943 287 1287 2051 1942 3915 2050 288 2049 51332 2048 1946 284217 2047 1945 1949 55816 1948 1944 1947 10154 8482 1600 55715 3912 8515 9355 8022 27255 6092 4902 1641 9260 284656 6230 80031 6210 9048 6231 9046 6234 285704 6235 6191 2197 6193 6192 6194 51065 140032 5576 6205 6227 6204 6207 6229 6206 6228 6209 6208 6188 6187 6223 6201 6189 3785 6222 3786 6203 6224 5532 6202 6218 6217 3921 4233 1272 3326 10627 8912 8913 8911 9861 6233 3312 7316 5578 10213 2909 5062 5706 5707 5708 5709 1981 5700 5701 1020 5702 10298 5704 5705 5682 5683 5621 5684 5685 5686 5717 5718 5719 11047 5713 27 5714 5690 5691 5692 5693 5694 7311 5695 7314 26986 5687 5688 5689 5058 28964 80728 1969 9475 6093 57453 1630 9423 1826 1284 1282 27330 6152 6155 6154 9901 6157 9349 6156 6159 6158 23521 51121 11224 57522 6164 1463 200916 6166 6122 6165 6124 6168 3320 6123 6167 5335 6169 6125 116832 1956 25873 6160 6161 9353 140801 6091 4736 5063 4650 6130 6133 57144 9045 6132 6176 6135 6134 6137 6136 1796 6171 9037 6170 6173 6128 8976 6129 5921 6142 6141 6144 6143 6146 6147 6181 6139 6138 56924 3690 3680 4684 3685 3674 3897 3678 8829 5604 5605 1299 1298 6456 375790 3673 1297 22885 84448 9495 3983 1212 10398 10109 10552 10093 10092 10095 10094 2932 10097 10096 2107 23708 10486 2935 26019 65110 8128 7903 5747 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%R-HSA-1474244.5 Extracellular matrix organization 2 7076 682 4312 5340 4313 50509 1286 1285 256076 169044 1280 81578 255631 57642 1310 340267 7373 136227 131873 91522 5175 1296 1295 1294 1293 1292 1291 1290 1305 1303 59277 3818 1302 1301 1289 3913 1300 1288 3914 1287 3915 2335 85301 1308 10319 3918 1307 284217 84570 655 3908 1511 1306 831 3909 7448 3910 3911 3912 84290 823 8515 824 826 1991 137868 10536 10893 92291 55214 64175 5645 10753 222663 825 827 3681 3682 1605 4052 440854 4054 23127 9313 2199 3695 27302 83700 8076 1821 2192 10516 726 2006 977 1838 652 84467 1837 2202 5650 2201 4320 5339 2200 4321 3696 164656 30008 11131 8200 23473 5644 84171 8425 11132 8910 4015 4319 4016 10491 4237 871 4017 5654 1508 4238 84695 4323 4324 4239 4325 4326 102 4327 5663 22801 23385 7177 6641 6640 85007 649 1504 8038 3386 3385 3384 3383 1756 147968 26254 87 6645 50859 440387 780 51399 79709 7087 7402 388743 4921 5351 6383 5352 6443 8985 6442 9672 6445 6444 6385 7412 7093 7092 80274 6382 8751 3684 8754 26577 58494 999 5118 8082 54221 960 961 3689 5578 1215 4680 4317 4318 3683 1520 1088 3676 3691 1278 3672 1277 22795 80781 3675 4322 3655 4811 836 64386 6696 101 5045 7040 6868 650 8573 1284 1282 1281 9378 1462 63827 1634 9644 7276 633 1463 7077 9510 50848 9507 140766 9508 9509 8728 3690 3680 4684 1509 3685 3674 4316 56999 3678 11096 11095 7043 54829 170690 7042 1299 170692 1298 3679 3693 8785 3694 634 7837 4146 3371 4060 6678 375790 3687 7143 2247 4593 7148 2331 63923 3381 176 3339 1311 4148 1758 1834 5054 3673 3688 1297 1404 8516 4038 5802 5479 3791 8974 283208 5033 3817 2244 2266 7057 2243 1514 1513 5154 1515 4314 5155 5034 TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME%R-HSA-5357786.6 TNFR1-induced proapoptotic signaling 1540 8737 27005 329 9099 841 10133 330 7375 7186 7124 7128 29110 10616 56957 220213 8717 7132 55072 9825 8772 9641 142678 331 81858 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME%R-HSA-166016.4 Toll Like Receptor 4 (TLR4) Cascade 1759 6279 6885 1785 671 7187 7186 7189 79155 7157 3661 29110 6280 7097 7096 26052 8772 10010 7335 9641 3665 10454 64127 929 8945 114609 59307 8737 11213 329 5970 353376 841 11035 330 7334 5781 148022 6271 8517 3146 23643 5594 5595 1386 7099 57162 5604 5598 51231 1849 84166 1147 1848 6285 1846 6288 1845 92610 6283 51295 51135 4214 8651 9684 4793 28512 57161 79671 3551 177 4615 121457 246330 5599 28511 3656 5775 257397 23118 1326 5609 466 80216 6416 4208 5601 7867 5602 5606 5519 3684 5515 5516 5518 7323 6233 7322 8767 948 3654 9261 3689 7316 695 5528 4791 7321 5608 3929 2244 2266 2243 9097 10133 23291 11274 1432 10333 4792 10392 4064 7311 6197 7314 6196 351 4790 9252 9450 6195 8454 4205 2353 5600 2002 6500 3725 5336 GSK3B-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 95%9929356 GSK3B-mediated proteasomal degradation of PD-L1(CD274) 5706 5707 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 4751 5685 5686 5717 5718 5719 10987 11047 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 9861 8454 6233 5687 5688 9978 5689 2932 7316 6500 10213 8945 29126 PHOSPHOLIPID METABOLISM%REACTOME%R-HSA-1483257.5 Phospholipid metabolism 22874 81846 126969 201164 55326 54477 56894 56895 3636 79887 1103 79888 5321 1120 114971 55224 5833 1119 100137049 149998 10400 5320 84803 57664 133121 5867 66036 137964 5868 114884 80339 8904 388121 114879 81544 114882 660 23446 57678 51365 253558 254531 55613 284161 5322 80821 55500 5319 55750 6901 9926 129642 23760 23761 23646 54675 8605 6305 23659 8443 8871 5305 80736 56994 23396 8867 10554 5130 8760 25816 3635 171586 146850 5294 23533 79837 79626 8897 8895 375 590 51763 126282 200879 63874 64600 5728 23171 248 30814 64850 5287 5288 377 1460 1459 5297 5298 1457 5293 51552 54947 43 374986 162466 347516 51205 11145 65977 9791 23259 51573 50487 10390 64419 56910 117245 4952 54979 10162 85465 2819 9107 9468 26279 10809 81579 84725 27124 22908 158835 22925 7179 56261 57110 204962 27132 255189 283871 9108 80230 8398 8399 375775 9489 255043 10908 9362 79153 8394 8395 283748 3032 3030 5783 79143 122618 154141 81490 57153 59339 59338 84879 5337 58488 5338 50640 151056 93492 8503 123745 84895 8776 5920 30849 90809 56623 5289 9663 8694 84649 2820 5286 8898 8821 9896 55361 9110 22876 200576 11343 54893 55300 64900 54545 55697 3631 4534 150763 23175 5295 5296 5290 5291 9600 1040 57605 83394 10423 57104 8396 10555 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 83464 51107 3065 10013 10014 6907 79718 9734 6868 51564 3714 9612 8841 9611 23493 3516 4609 892 3066 9759 23462 8850 6233 3280 9978 79885 7316 55869 22938 55534 83933 9794 2648 1387 2033 28514 1024 182 7311 7314 84441 8454 9148 10046 54492 4851 142678 26508 388585 6500 57534 102 54567 5663 23385 55851 5664 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%R-HSA-3270619.3 IRF3-mediated induction of type I IFN 3661 340061 29110 147945 23220 11277 4361 2547 7520 51428 3428 197358 5591 TRAF3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 95%5602571 TRAF3 deficiency - HSE 7098 7187 148022 CHL1 INTERACTIONS%REACTOME%R-HSA-447041.3 CHL1 interactions 3312 286 3673 8829 8515 3688 27255 10752 3672 ROBO RECEPTORS BIND AKAP5%REACTOME DATABASE ID RELEASE 95%9010642 ROBO receptors bind AKAP5 5578 5566 5567 6092 5576 9495 5568 5532 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME%R-HSA-389397.3 Orexin and neuropeptides FF and QRFP bind to their respective receptors 84109 3060 64106 10886 3062 3061 347148 8620 MRNA EDITING%REACTOME%R-HSA-75072.5 mRNA Editing 200315 339 9582 10930 103 104 27350 29974 164668 403314 LXRS REGULATE GENE EXPRESSION TO CONTROL BILE ACID HOMEOSTASIS%REACTOME DATABASE ID RELEASE 95%9623433 LXRs regulate gene expression to control bile acid homeostasis 54659 7376 6256 9612 10062 6257 9611 2172 8648 DEFECTIVE ABCA1 CAUSES TGD%REACTOME%R-HSA-5682113.5 Defective ABCA1 causes TGD 335 19 SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 95%5693548 Sensing of DNA Double Strand Breaks 10524 3838 10111 4361 472 4683 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME%R-HSA-5358606.3 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 4292 4436 5111 9156 10714 5424 5395 5425 4437 57804 3978 6117 6119 6118 SENSORY PERCEPTION%REACTOME%R-HSA-9709957.5 Sensory Perception 81327 81442 50840 132112 2774 393046 8390 109 8392 122742 26494 401427 26493 26496 401667 401666 282775 122740 401665 26497 81470 81472 282770 341276 122748 3710 127074 341152 256144 1262 127077 1260 283617 120796 81469 119694 119695 120793 282763 81466 7804 81341 343563 119692 1109 387748 490 344892 79290 79296 135924 79295 338 26595 3778 26476 3779 284532 125958 442191 26246 442194 26248 442197 81127 26245 284521 135941 26339 26338 135946 26219 135948 121214 26692 402317 26693 26333 26696 26212 2339 81399 26211 80331 81392 6709 388761 5864 343406 26341 6616 2934 4836 830 255022 119395 6383 221914 9672 10082 6385 3292 2262 6382 2239 4036 2719 2817 4478 829 2792 8861 2784 51764 5588 5959 6017 158835 2782 832 6711 7276 1645 151056 808 10170 9249 8608 51109 8644 157506 2911 4641 129446 440699 25861 27445 161497 124590 51168 11344 64072 8927 4647 53904 494513 9750 9478 259236 338328 65217 23136 339768 117532 117531 25794 283310 340990 643226 286262 375611 4354 10518 4023 776 5357 53405 9254 7430 10083 64787 222662 83715 783 389207 2059 335 336 51475 5962 337 6853 140469 6855 3949 345 4627 6324 6330 6335 6326 54795 6328 6327 29850 9355 5145 24 5158 5148 9132 5330 5756 64220 9227 5950 145226 5956 5947 6804 56656 120065 121275 120066 283365 390883 390882 390649 5949 9381 124538 390648 5578 283111 4991 4992 4993 442184 442185 442186 79310 79317 284433 341799 219954 219952 121130 79541 79544 121364 125963 125962 4994 79549 4995 283694 121129 133060 5726 219965 130075 219960 390431 390433 442361 390436 390437 390439 341418 79334 341416 79339 219959 219958 219957 219956 283162 6844 138804 65055 138805 283160 138802 138803 390441 390442 390321 390201 390323 390445 390326 390327 144124 254973 144125 79324 283159 219968 127608 219986 219865 219983 219982 390892 219981 57101 401994 401993 259289 401992 285659 259287 259286 259285 81309 79473 81797 390538 7932 219858 259293 259292 219875 219874 259290 219873 219870 259296 259295 390429 79346 79345 26188 81300 26189 50700 2652 219869 347168 26716 8573 286365 283093 283092 347169 138799 390113 134083 391211 392309 150681 338674 338675 340980 283189 219417 219438 219437 219436 26707 219432 219431 338662 6010 126541 6295 403282 6011 3000 403284 127623 2986 1259 254879 1258 283297 5957 255725 219429 9397 219428 131890 54429 5475 2342 284383 4035 126370 29967 2779 10988 390271 219447 23173 83875 388531 390151 79823 391121 390152 9626 5948 441308 2979 390154 26020 2978 55584 54884 390275 3781 441669 57016 390155 6340 53630 57053 5406 390157 390036 55937 80835 1208 390037 80834 390038 441670 158131 138882 6337 138883 6339 138881 6338 23538 390162 219453 390167 390168 347468 8630 219469 1879 219464 338751 391107 391109 338755 254786 611 254783 10798 390260 390261 219479 390142 219477 162998 390264 391112 390144 390265 391114 219473 390148 79501 286362 390072 390195 390075 390197 390077 219487 390199 392376 3759 390078 390079 219484 219482 392138 127385 143502 119764 119765 143503 81050 375790 390081 390082 390083 2036 390084 6121 26687 119749 402135 3339 26689 219493 81168 81285 392391 81282 392390 504190 390174 390054 26533 346562 256892 390058 26532 344 390059 26534 26658 26539 26538 348 26659 26531 343173 390181 390061 343172 343171 343170 390063 441639 390064 389090 390066 390067 26664 343169 390190 81061 390191 403274 127062 403277 403278 127069 127068 127066 403273 127064 120787 9187 119687 81099 119682 26529 441933 127059 26648 120775 120776 119678 119679 2914 390093 392392 403253 441608 403257 391189 26735 128371 26737 8590 128372 391190 196335 346525 391192 391191 391194 391196 403244 285440 391195 128366 128367 128368 128360 119774 119772 26740 403239 346517 79490 81328 83756 120586 256148 81696 81697 50831 50833 50832 50834 50837 8387 246213 50836 8388 50839 50838 8386 8383 81318 79482 81448 AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 95%156587 Amino Acid conjugation 54988 389396 116285 348158 10249 123876 341392 219970 92292 TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION%REACTOME%R-HSA-9843743.1 Transcriptional regulation of brown and beige adipocyte differentiation 57504 655 57459 5468 4086 9112 1149 64641 3065 63976 7350 54815 23090 3192 4089 53615 8648 5928 10891 1107 5931 3066 133522 5465 1346 6256 83401 1108 9219 SIGNALING BY HIGH-KINASE ACTIVITY BRAF MUTANTS%REACTOME%R-HSA-6802948.2 Signaling by high-kinase activity BRAF mutants 673 8826 2244 2266 7414 8844 10256 54518 5894 22866 5906 4140 5908 7450 5037 2243 7094 1445 7529 369 283455 408 409 4893 5594 5595 3690 3674 6714 5604 5605 2335 3265 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%R-HSA-3769402.5 Deactivation of the beta-catenin transactivating complex 6662 7088 9757 7089 3065 84661 11091 7091 207 83439 1499 6657 51176 5929 1487 6932 6934 90780 57680 9580 56998 283149 83595 64321 25776 26108 4221 55553 6658 607 6736 6659 7311 7314 6233 7090 9070 208 7316 324 331 7514 7534 8945 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%R-HSA-2500257.7 Resolution of Sister Chromatid Cohesion 348995 6396 57122 55746 23279 79023 79902 5903 54908 6232 8655 25909 8379 9183 1063 1062 9184 1060 991 151648 8243 55166 9126 23244 23047 1058 79019 10735 151246 23063 9735 5885 10274 23332 79003 55055 81565 22919 348235 5048 23421 220134 57082 57405 51143 147841 4085 64105 401541 10403 54820 80776 701 54821 378708 1781 23122 1780 79172 1778 81930 55920 84643 3796 9793 91687 57551 79682 5905 1783 5501 83540 80152 2491 5519 332 55143 699 11243 3619 140735 5515 11004 5516 5518 9212 25936 11130 64946 79980 10726 5525 5526 55839 5527 5528 7514 5529 891 983 5347 55732 113130 9133 6249 AXIN MISSENSE MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 95%5467340 AXIN missense mutants destabilize the destruction complex 5515 5516 5518 5525 5526 8312 2932 5527 324 5528 1452 5529 139285 5519 DASATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669914.2 Dasatinib-resistant KIT mutants 3815 GAMMA CARBOXYLATION, HYPUSINYLATION, HYDROXYLATION, AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 95%163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 632 5045 285362 89978 79642 92715 1938 25870 51611 285381 340075 120526 91433 1802 100137047 11338 1801 79697 55854 410 79831 1819 412 414 51389 4733 415 55239 65094 416 8459 8460 22901 153642 347527 6157 411 2107 444 6132 6194 2677 2159 2621 83475 2147 64122 6228 1984 2158 2155 23463 8858 79672 5624 56648 5627 1725 84864 2157 23210 BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 95%8851680 Butyrophilin (BTN) family interactions 79908 11119 11118 696 56244 7498 30835 11120 5493 10385 153579 10384 INHIBITION OF NITRIC OXIDE PRODUCTION%REACTOME%R-HSA-9636249.2 Inhibition of nitric oxide production 4843 3836 3837 METALLOTHIONEINS BIND METALS%REACTOME DATABASE ID RELEASE 95%5661231 Metallothioneins bind metals 4493 4494 4495 4496 4499 4489 4501 4502 4504 84560 4490 GSD IB%REACTOME DATABASE ID RELEASE 95%3229133 GSD Ib 2542 RESISTANCE OF ERBB2 KD MUTANTS TO SAPITINIB%REACTOME DATABASE ID RELEASE 95%9665244 Resistance of ERBB2 KD mutants to sapitinib 11140 3320 2064 55914 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 95%76002 Platelet activation, signaling and aggregation 4352 51706 2 7076 7078 7873 7114 3671 66005 5894 213 3273 5906 335 3827 5908 1521 6414 6810 11069 139322 308 10411 3700 6814 10235 6813 10125 10487 3309 7123 5340 5341 5345 3710 29106 83706 3959 54676 710 1893 259215 5473 10184 78991 51571 967 9948 7222 6694 5321 5004 334 5919 7225 55664 5874 7018 3699 1191 374354 7273 1398 10447 5175 54863 5005 2316 81 5768 2812 57113 3708 3709 2815 2814 2335 51206 14 10451 150 7410 151 152 7409 10630 51266 80739 27154 87 10672 2207 5879 6915 5580 4067 146850 5294 5578 23533 7534 5478 6647 207 1072 2793 2792 1432 2791 5581 2790 5582 5579 2788 2787 2786 2785 2784 2783 51764 9630 94235 5588 1675 55970 7040 54331 2767 59345 408 409 2769 7277 2782 2776 10681 5880 1950 9564 5590 5196 5781 8503 998 5594 5595 3690 3674 387 391 388 7043 6654 7042 6678 5099 11343 5216 5583 9162 8527 26090 8525 5054 8526 5295 57406 5296 5770 221955 160851 6464 346562 1609 747 5290 1608 5291 1607 5170 1606 139189 808 88 948 2811 2771 6714 7422 2770 2768 7424 7423 2277 2773 2244 2266 7057 7414 54518 5028 7450 2243 3937 7094 1445 226 27040 2534 6850 3932 7044 3082 5265 2621 22915 2147 10490 5777 5267 29789 2153 5627 3481 350 94121 351 197 3479 51368 64805 8407 10257 12 2151 5155 5552 2149 22927 2162 1 51097 23052 5747 2157 9749 3920 928 135228 9002 54495 5660 10916 5336 6403 813 7066 REGULATION BY TREX1%REACTOME DATABASE ID RELEASE 95%3248023 Regulation by TREX1 11277 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME DATABASE ID RELEASE 95%211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 5706 5707 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 9861 6233 5687 5688 5689 7316 10213 5062 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 95%397014 Muscle contraction 301 783 5566 2983 2982 6546 4842 4629 6547 3710 775 103910 4637 80228 487 488 6324 489 6323 84876 7220 6331 6717 6330 490 6332 491 492 6335 493 6334 6326 7273 6328 6327 6786 6329 5829 6543 2977 6336 11280 3708 3709 55800 9424 3775 3751 10089 3752 56659 4878 3757 3770 338567 3776 3777 51305 3784 83795 54207 50801 30819 3750 4606 4607 60598 89822 3753 3741 30820 29766 4604 9992 56660 1756 23704 8557 4621 4624 7169 4626 7168 7111 10174 4632 493829 4633 8291 4634 25802 4635 58498 7125 217 59285 93408 59284 859 7134 10580 7136 10627 7135 140465 7138 29895 7137 8912 800 7140 7139 8913 80333 8911 2259 309 4636 2258 4638 2257 2256 6910 89 29767 29765 10008 29098 1760 1482 1674 4703 8645 23630 5062 10142 302 10768 3672 5058 476 477 478 53822 53826 7431 53828 8654 480 1193 481 2281 482 483 486 782 6263 6262 6261 8850 5350 444 5348 5349 10345 6588 25937 30818 3761 3759 3693 27092 3768 7170 7171 59283 808 88 10398 815 816 817 818 7414 7094 4880 4881 204851 4882 4311 1066 10699 2626 10060 28996 3767 9254 FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME%R-HSA-6781823.4 Formation of TC-NER Pre-Incision Complex 2873 51138 9318 10450 91603 7874 6233 57654 9978 27339 7316 5440 5441 4331 1022 2071 2966 1161 2965 9716 2068 5434 5435 5436 5437 5438 5439 2968 8451 2967 404672 8533 5430 5431 5432 64708 5433 902 6917 10987 10980 57461 50813 10920 1642 7311 7507 2074 7314 56949 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME%R-HSA-68616.6 Assembly of the ORC complex at the origin of replication 474382 54145 3837 23633 8970 8331 8337 128312 8334 8335 8370 55766 8968 8341 8342 8347 8348 94239 8345 3013 8340 8338 5000 255626 5001 3021 653604 3836 3018 23595 3017 23594 85236 3014 4998 4999 8349 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%R-HSA-201681.3 TCF dependent signaling in response to WNT 9101 84661 11091 8452 5929 1455 80351 9070 8295 8607 8395 8945 9757 4040 22943 7483 4041 89780 6423 1487 11197 6422 90780 27121 57680 9580 79412 83999 56998 27123 283149 83595 50964 64321 8970 25776 1855 8331 26108 55553 6658 8337 128312 607 8334 6736 6659 8335 6597 2033 8370 1857 55766 1856 8968 7855 8341 8322 8342 8347 8290 79577 8348 94239 7090 8323 8345 3013 123169 8340 2535 8338 208 255626 3021 653604 3018 3017 85236 3014 8349 474382 7088 54145 7089 3065 7091 83439 1499 51176 6932 6934 7015 4221 5519 4609 8321 8325 7471 6259 5515 5516 5518 9861 81847 6233 7473 9736 7479 7478 9978 51339 59349 5525 23072 5526 8312 440193 2932 5527 7316 324 5528 1452 7514 5529 8658 139285 10213 7534 8313 1454 5706 5707 6662 5708 5709 59352 55366 207 343637 5700 5701 340419 54894 5702 8549 6657 284654 84133 5704 5705 64750 5682 5683 5684 5685 5686 5717 5718 5719 1460 11047 1387 5713 1459 5714 5690 5691 1457 5692 5693 5694 54361 7311 7979 5695 7314 857 5687 5688 10524 5689 23401 10023 84870 331 7474 864 TRANSLATION%REACTOME%R-HSA-72766.7 Translation 54471 6150 55168 64949 28973 65080 51642 54998 5018 10573 11222 128308 51649 9553 64960 92259 64963 63875 64965 64968 55052 55173 64969 51250 51373 26284 51650 51253 60488 51258 219927 29074 56945 28998 64975 79590 64976 64979 115416 64978 23107 28957 64928 4706 7818 51263 29088 51021 57129 54534 51023 51264 51069 84545 78988 122704 65993 64981 10240 64983 3396 63931 26589 54460 6182 6183 118487 51073 116540 740 124995 8893 54148 8891 116541 8892 55037 8890 29927 29093 1967 9801 51116 10884 54948 51318 6230 6210 6231 6234 6235 6191 2197 6193 6192 6194 51065 140032 55666 6205 6227 6204 6207 6229 6206 6228 1915 58477 6745 6209 6208 6188 6187 6223 6201 6189 6222 6203 6224 6202 6218 6217 3921 6734 84164 10973 1650 6185 6184 8894 2058 8662 1965 8663 8661 8666 8667 1975 8664 1968 8665 27335 3646 51386 7458 8668 1978 8669 1977 10480 1964 55176 8453 9861 7323 6233 7322 26046 9978 51504 9617 7316 57505 6921 7453 6923 16 10667 4508 55699 6175 10213 4509 27068 23480 1917 54938 84340 6727 8565 22980 5706 23395 5707 123263 5708 23008 833 5709 7353 4512 10056 4513 1937 4514 1936 1981 4528 1933 5700 4519 55139 5701 124454 9669 5702 4539 6731 6730 5704 80222 5705 6729 85476 5682 6726 5683 6728 5684 55157 5685 79587 5686 23471 5717 4677 5718 219402 5719 54516 4540 6746 6748 4541 6747 11047 1983 10352 5713 4535 23438 5714 90850 4536 5690 3035 4537 5691 25973 4538 5692 6897 5693 2617 5694 9147 10952 5464 7311 5695 2193 79731 7314 92935 26986 57038 10102 51067 5687 92399 5688 57176 5689 9789 23478 60559 28972 90701 6152 6155 6154 6157 9349 6156 6159 6158 23521 51121 11224 6164 200916 6166 6122 6165 6124 6168 6123 6167 6169 6125 116832 25873 6160 6161 140801 4736 53918 6130 6133 9045 6232 6132 6176 6135 6134 6137 6136 6059 7415 6171 6170 6173 6128 6129 6142 6141 6144 6143 6146 6147 6181 1974 6139 1973 6138 1938 7284 2107 29104 7321 327 23708 2935 51520 1615 3376 7965 9521 9255 6301 5859 4141 5917 3735 7979 91574 64432 65003 64951 65005 65008 28977 90480 51081 UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME%R-HSA-438066.5 Unblocking of NMDA receptors, glutamate binding and activation 2892 808 88 2891 2893 2890 1742 1741 1740 2906 1739 2905 815 2904 2903 816 4747 2902 817 818 REGULATION OF CORTICAL DENDRITE BRANCHING%REACTOME%R-HSA-8985801.2 Regulation of cortical dendrite branching 6585 8440 6091 6092 INOSITOL PHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 95%1483249 Inositol phosphate metabolism 253430 84812 5332 64768 3705 4952 51447 3706 3707 9807 5335 51196 89869 122618 8821 51477 3628 80271 66036 5728 3631 27124 3636 808 5330 8867 5331 9108 9562 11163 23236 23007 55586 3613 170685 3635 3612 23262 11165 3632 3633 117283 9651 5333 5336 113026 9677 55190 MPS I - HURLER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953038.1 MPS I - Hurler syndrome (CS DS degradation) 3425 REGULATION OF HMOX1 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9707587.4 Regulation of HMOX1 expression and activity 571 3162 81502 4780 7975 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 95%111996 Ca-dependent events 113 114 115 107 108 109 196883 5566 5567 5568 5153 5573 5575 5576 5577 5582 5613 156 3838 5137 10645 26960 5321 84254 814 808 5594 5580 5136 815 5578 816 817 818 111 112 DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 95%5663202 Diseases of signal transduction by growth factor receptors and second messengers 27436 10956 3516 2931 930 79885 83933 4869 3549 2263 5782 3002 4000 10018 7409 102 1849 54567 1848 5663 1639 23385 55851 5664 55750 83464 51107 572 9061 8878 5599 5879 55615 7750 9978 4067 55869 146850 8658 5294 23533 5440 5441 2261 4193 833 2064 2963 4087 1937 2962 4088 5434 5435 4089 5436 7297 5437 54894 5438 5439 5728 5430 5431 5432 5433 3586 4478 5495 3164 238 5293 4303 7525 399687 80304 55109 2305 161742 27044 4763 57670 57448 8496 22808 9734 399473 11221 6868 8805 56829 57599 3714 53335 408 10342 9715 80351 409 200734 4170 471 23164 3092 8546 7157 64840 6238 57085 11044 11052 54845 9444 2804 9451 9208 1852 1850 8850 10827 8036 50616 50507 26127 8087 941 942 6711 5880 6199 50852 253260 7175 5903 2099 7415 9794 2648 5781 4893 7535 8503 27006 2549 8660 5594 5595 10818 10046 81608 208 8817 26281 9965 391 1147 6654 2254 3265 2252 2251 597 8074 2249 3662 2248 2247 2246 2323 2322 152831 8823 5501 5295 7170 5296 7171 6464 2264 5519 5290 5291 1523 5170 2255 9846 9648 3667 5515 5516 3845 808 5518 3084 5525 5526 815 5527 5528 5500 5529 6714 816 3791 817 22938 818 8315 5245 3717 673 2244 5551 23189 2120 2266 29851 3587 7414 51411 6801 8844 51530 10256 6776 2803 54518 22866 4140 7450 5037 9321 2243 891 7094 1445 369 283455 22916 10817 4686 2534 3932 3082 28514 182 7979 8454 1213 5155 9148 54492 142678 26508 388585 6500 57534 6249 4916 4908 5894 5906 5908 4627 22872 5292 10533 9530 2335 4040 22943 4041 89780 27121 79412 83999 27123 6194 5573 5156 7855 8322 3815 8323 57674 4851 1839 80853 4233 3065 1026 1499 6934 1051 2308 4609 4343 192669 26523 192670 27161 64223 57690 2280 9861 6233 84335 2475 7249 7316 2100 10213 5706 5707 5708 5709 207 5700 5701 5702 7529 10142 5704 5705 5682 11116 5683 5684 5685 5686 5717 5718 5719 11047 5713 4008 5714 5690 5691 5692 1024 5693 5694 7311 5695 7314 613 5687 5688 5689 1185 842 80824 2260 79109 55914 7046 10013 7048 7040 10014 6772 940 892 4296 118788 3280 2885 6777 55534 8826 11140 3320 1950 5335 867 1956 1488 1487 1027 5925 2033 5159 9542 10718 145957 84441 3690 3674 6774 5604 55733 5605 6469 50846 6907 79718 84447 5601 9612 51564 8841 9611 23493 8325 3066 9759 3799 23462 8312 2932 324 1452 139285 22906 3831 7291 374 598 1387 27248 51009 5777 6400 4915 4909 627 11160 7039 685 255324 3726 1786 2069 10000 2309 3725 REGULATION OF ENDOGENOUS RETROELEMENTS BY THE HUMAN SILENCING HUB (HUSH) COMPLEX%REACTOME DATABASE ID RELEASE 95%9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 474382 54145 54737 23517 79813 55729 10919 8970 8331 8337 128312 8334 8335 9869 51535 8370 55766 8968 8341 8342 8347 55596 8348 23272 94239 10179 8345 3013 8340 8338 255626 22880 3021 653604 3018 3017 85236 3014 8349 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 95%450341 Activation of the AP-1 family of transcription factors 5601 5602 5594 3725 5595 1432 1386 5599 2353 5600 BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME%R-HSA-9018896.2 Biosynthesis of E-series 18(S)-resolvins 246 4048 240 3248 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL1%REACTOME DATABASE ID RELEASE 95%9616334 Defective Base Excision Repair Associated with NEIL1 79661 DEFECTIVE GCK CAUSES MATURITY-ONSET DIABETES OF THE YOUNG 2 (MODY2)%REACTOME%R-HSA-5619073.4 Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) 2645 EUKARYOTIC TRANSLATION INITIATION%REACTOME%R-HSA-72613.5 Eukaryotic Translation Initiation 6152 6155 6154 6157 9349 6156 6159 6158 23521 51121 11224 6164 200916 6166 6122 6165 6124 6168 6123 6167 6169 6125 116832 8893 25873 8891 6160 8892 6161 8890 140801 4736 1967 6130 6133 9045 6230 6232 6132 6210 6176 6231 6135 6234 6134 6235 6137 6191 6136 2197 6193 6171 6192 6170 6194 6173 6128 51065 6129 140032 6142 6205 6227 6141 6144 6204 6143 6207 6229 6146 6147 6206 1974 6228 6181 1973 6139 6138 6209 6208 6188 6187 6223 6201 6189 6222 6203 6224 6202 6218 6217 3921 8894 8662 1965 8663 8661 8666 1975 8667 8664 1968 8665 27335 3646 51386 7458 1978 8668 1977 8669 10480 1964 6233 6175 1981 9669 1983 7311 26986 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%R-HSA-166663.4 Initial triggering of complement 629 2219 718 4153 721 78989 5648 712 713 714 715 716 717 2220 1401 8547 10584 1675 3004 RESPONSE OF ENDOTHELIAL CELLS TO SHEAR STRESS%REACTOME DATABASE ID RELEASE 95%9860931 Response of endothelial cells to shear stress 113 114 115 10266 107 108 55970 109 10203 196883 3551 5566 5567 1499 5568 54331 2767 4846 59345 3688 6772 5296 5770 5519 10413 5290 5291 5170 55615 2782 5515 2776 64223 808 59341 5518 10681 2475 5175 9641 2778 9780 1003 2324 3791 25 253260 7414 84290 207 824 5970 826 5029 7094 302 5586 2793 5520 2792 5573 2534 5575 2791 5576 5577 2790 2788 8517 2787 4792 2786 2785 5293 2784 4790 2783 51764 3690 3685 3678 5747 4323 94235 24145 79109 1147 133 111 112 DEFECTIVE F8 BINDING TO VON WILLEBRAND FACTOR%REACTOME%R-HSA-9672393.2 Defective F8 binding to von Willebrand factor 2157 7450 MICRORNA (MIRNA) BIOGENESIS%REACTOME%R-HSA-203927.5 MicroRNA (miRNA) biogenesis 6895 54487 192669 26523 5434 192670 5435 27161 5436 5901 5437 5438 5439 5430 5431 5432 5433 144233 57510 5440 29102 5441 23405 8575 VRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 95%192905 vRNP Assembly 3320 3843 MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 95%190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 2697 MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-1592230.4 Mitochondrial biogenesis 516 517 10651 518 84833 56652 10498 521 522 139322 6907 11232 8648 54927 5442 79718 27109 5563 4208 6742 5564 10891 5565 498 8841 539 9611 10476 23054 51422 51106 5571 211 6300 808 133522 53632 5465 23409 4508 4509 3054 6648 23408 2551 440574 79135 23082 10989 2746 125988 5469 10632 3313 4209 55735 3418 84303 4580 7978 84808 8834 4899 2747 80205 23373 85441 10499 2101 96764 9551 64784 1432 200186 9556 1387 25813 814 55902 9572 1386 7019 64216 23410 5600 509 6256 506 6604 513 54205 514 515 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 95%399997 Acetylcholine regulates insulin secretion 23236 2767 2776 5578 9630 4082 5330 5331 1131 2769 DEFECTIVE SERPING1 CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657689.2 Defective SERPING1 causes hereditary angioedema 2161 3818 710 MECP2 REGULATES TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 95%9022707 MECP2 regulates transcription factors 5468 4208 54715 RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME%R-HSA-5693565.6 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 51588 54145 9656 9682 5599 51035 8924 7157 7341 29086 7329 6233 51720 8467 7316 11200 25 8314 165918 7468 7158 2070 5536 7334 322 2140 8970 472 7336 2139 2138 9025 672 128312 79184 8370 10111 7311 8341 4361 7314 8342 8347 8290 8348 8345 84142 4683 9031 9577 580 8340 10524 255626 3018 3017 85236 3014 23030 8349 MECP2 REGULATES TRANSCRIPTION OF GENES INVOLVED IN GABA SIGNALING%REACTOME DATABASE ID RELEASE 95%9022927 MECP2 regulates transcription of genes involved in GABA signaling 2572 2571 TELOMERE EXTENSION BY TELOMERASE%REACTOME DATABASE ID RELEASE 95%171319 Telomere Extension By Telomerase 55651 51750 55135 23243 1017 26277 25913 7013 7015 80119 10856 65057 7014 55164 1736 54386 55291 890 8607 8900 5537 55505 54433 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%R-HSA-933543.5 NF-kB activation through FADD RIP-1 pathway mediated by caspase-8 and -10 7706 89122 8737 8517 843 23586 3551 64135 84282 841 57506 8772 1147 CDH11 HOMOTYPIC AND HETEROTYPIC INTERACTIONS%REACTOME DATABASE ID RELEASE 95%9833576 CDH11 homotypic and heterotypic interactions 1495 64403 1006 1500 3728 1009 1499 FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE%REACTOME%R-HSA-2855086.3 Ficolins bind to repetitive carbohydrate structures on the target cell surface 2219 2220 8547 5648 PENTOSE PHOSPHATE PATHWAY%REACTOME%R-HSA-71336.8 Pentose phosphate pathway 22934 55276 7086 6888 6120 221823 729020 23729 5631 25796 5634 64080 5226 2539 51071 SIGNALING BY FGFR1%REACTOME DATABASE ID RELEASE 95%5654736 Signaling by FGFR1 673 2251 8074 5335 867 10755 2249 3730 2248 2247 2246 161742 10817 23768 23769 53834 5295 10253 200734 8569 5781 23767 4893 5290 27006 2255 7049 2549 5515 7311 5516 7314 5518 5594 5595 6233 10818 7316 8817 26281 6654 2254 3265 CTNNB1 S37 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358749.4 CTNNB1 S37 mutants aren't phosphorylated 5515 5516 5518 1499 5525 5526 8312 2932 5527 324 5528 1452 5529 139285 5519 DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS%REACTOME%R-HSA-5678895.5 Defective CFTR causes cystic fibrosis 5706 5707 5708 91445 5709 6048 91319 5700 5701 5702 10956 5704 5705 5682 5683 5684 5685 5686 7415 5717 5718 5719 1080 27248 11047 79139 5713 5714 51009 5690 5691 5692 5693 6400 5694 7311 7979 5695 7314 9861 11160 6233 5687 5688 5689 7316 10213 10613 DEFECTIVE OGG1 LOCALIZATION%REACTOME DATABASE ID RELEASE 95%9657050 Defective OGG1 Localization MATURATION OF NUCLEOPROTEIN%REACTOME DATABASE ID RELEASE 95%9694631 Maturation of nucleoprotein 7341 3276 143 2931 56965 7329 83666 84875 79668 54956 54625 2932 1452 6732 6733 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%R-HSA-937041.3 IKK complex recruitment mediated by RIP1 8737 8517 329 7311 7314 3551 23643 7323 7099 7322 6233 353376 11035 7335 330 7316 7334 929 1147 7189 148022 7321 ACTIVATION OF SMO%REACTOME DATABASE ID RELEASE 95%5635838 Activation of SMO 6608 11127 3549 5727 50937 91653 132884 1452 2121 23288 408 2622 6469 84455 409 50846 2619 156 CELLULAR RESPONSE TO CHEMICAL STRESS%REACTOME DATABASE ID RELEASE 95%9711123 Cellular response to chemical stress 213 1327 1329 475 1340 1337 1339 343 1351 1350 1349 1347 1346 1345 10072 8945 7086 5584 5970 538 26043 125965 64839 571 55666 23657 4851 4097 5753 6604 5226 4363 613227 8714 25942 1029 8878 1026 5563 3417 468 4609 4697 3040 5580 9861 6233 9978 7316 3162 10213 6648 5706 5707 1536 5708 5709 7353 4512 1535 4513 6647 4514 6888 207 5700 5701 4688 5702 4689 5704 5705 5682 5683 114548 5684 5685 5686 5717 5718 5719 1460 11047 5713 1459 5714 5690 10628 5691 1457 5692 5693 5694 7311 847 5695 79594 7314 4790 84701 3043 5687 5688 5689 9429 653361 54205 81502 8452 10498 341947 9451 6737 81631 50507 5465 9817 25828 9588 5469 1950 2950 6502 2876 3163 7415 55620 493869 140809 79400 30001 10061 257202 2033 2938 1728 2940 10935 27244 644 645 84181 6649 318 2880 2878 10587 2882 9973 208 6256 6774 2168 6347 5052 6907 7001 8648 79718 9377 9612 8841 9611 23054 83667 9167 2932 139285 4199 2539 7296 2730 2729 7295 80205 85441 10499 96764 374 596 4780 5154 672 598 1387 6667 7975 7979 8454 2877 10000 6500 79728 5034 CHROMATIN ORGANIZATION%REACTOME DATABASE ID RELEASE 95%4839726 Chromatin organization 84661 23186 11091 25855 5926 5928 10362 5929 51317 5931 9070 1108 57504 23506 65980 9112 29998 63976 83933 5970 10765 58508 5978 29117 6187 1386 22992 6601 51780 6603 6602 84864 6605 8242 5253 6604 23210 23133 8284 55693 23030 84159 80853 84678 27154 7404 57459 3065 595 79813 10419 6880 6883 10856 56950 55869 7994 56979 7468 93624 80314 8473 317772 4790 85235 64426 196528 86 2146 23326 84289 60 10498 57634 6881 7862 53335 10474 3276 221613 9739 8850 8295 11240 92815 51412 2122 8969 8607 8726 440689 3054 23774 9757 6314 1019 53615 8970 8331 4297 2648 8337 128312 8334 6595 8335 64769 6597 2033 6599 8370 6598 55766 10445 8968 23135 8341 8342 8347 8348 51230 94239 8345 3013 8340 29943 84444 27097 8338 5927 55578 255626 9767 9643 54014 353238 653604 64754 3018 117143 3017 11143 85236 10196 6944 3014 54496 8464 79084 55929 55170 55352 5077 8349 55250 55257 474382 10629 26610 23587 55140 54815 83852 54859 79918 23028 55274 9682 51111 23569 55167 6907 10933 64324 8648 23338 10943 56943 79718 9913 51147 51702 8289 55870 55193 23522 9612 10919 54556 56970 8841 84193 55683 79960 9611 55689 64919 10902 79723 221656 29072 9869 339287 84787 1107 2874 8520 80854 387893 54904 8518 54934 3066 55818 23512 1810 51562 5977 79685 8089 6839 8085 4791 605 8110 9219 3717 79595 57325 23081 84148 10284 6871 26039 284058 10499 55729 6760 9575 8819 1387 121536 57492 26009 9274 9275 10524 1788 7403 8193 112869 51742 23067 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 95%196025 Formation of annular gap junctions 1213 1601 1211 1173 1785 8218 2697 1759 1212 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 95%75067 Processing of Capped Intronless Pre-mRNA 55339 10914 51585 1479 1478 1477 22916 29894 4686 84967 11051 134353 7884 79869 10978 25888 53981 6628 8189 8106 6634 81608 51692 10898 6636 23283 6635 6637 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME DATABASE ID RELEASE 95%1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 3320 5805 2644 2643 4846 6697 207 808 1719 5593 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME%R-HSA-399954.4 Sema3A PAK dependent Axon repulsion 3320 5362 10371 2242 3326 5063 55558 1072 5879 5058 3984 8829 91584 2534 5361 5062 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME%R-HSA-75035.6 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 7532 7531 7465 7533 891 983 995 7529 2810 890 8900 11200 7534 1111 10971 TGFBR3 PTM REGULATION%REACTOME%R-HSA-9839383.1 TGFBR3 PTM regulation 83464 7076 51107 7049 4323 4325 5663 7077 23385 55851 5664 DEFECTIVE BINDING OF VWF VARIANT TO GPIB:IX:V%REACTOME%R-HSA-9846298.1 Defective binding of VWF variant to GPIb:IX:V 2811 2812 7450 2815 2814 TRIGLYCERIDE CATABOLISM%REACTOME%R-HSA-163560.5 Triglyceride catabolism 2170 2820 2169 5346 2168 2167 150379 8228 5566 857 2172 5567 11343 646486 5499 3991 5568 646480 51099 5500 10226 5501 2173 2171 PHOSPHO-PLA2 PATHWAY%REACTOME DATABASE ID RELEASE 95%111995 phospho-PLA2 pathway 5321 5594 DEFECTIVE LARGE CAUSES MDDGA6 AND MDDGB6%REACTOME DATABASE ID RELEASE 95%5083627 Defective LARGE causes MDDGA6 and MDDGB6 11041 9215 INTERLEUKIN-21 SIGNALING%REACTOME DATABASE ID RELEASE 95%9020958 Interleukin-21 signaling 3716 3561 59067 6776 6774 6772 50615 3718 6775 6777 CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 95%1614603 Cysteine formation from homocysteine 1491 875 COMPLEX IV ASSEMBLY%REACTOME DATABASE ID RELEASE 95%9864848 Complex IV assembly 90639 4512 55969 4513 25994 4514 10063 80775 1327 125965 9377 84987 100303755 55744 51204 1329 285521 1340 6834 4697 1337 341947 80219 1339 9167 84701 1351 100131801 1350 29090 192286 152100 93058 9997 1349 389203 1347 116228 1346 1345 28958 51241 6341 1355 79064 1353 493753 RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME%R-HSA-5693554.3 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 7486 116028 472 10635 672 675 83990 51750 7516 10111 5932 7517 7979 4361 7156 5890 9156 5892 4683 580 10524 641 1763 79728 5888 80010 5889 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 95%983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 4690 29760 973 974 640 3710 5295 2534 6850 80228 84876 7220 5777 10768 930 5293 808 118788 933 27071 6786 4067 695 3708 3709 7409 6654 5336 30011 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%R-HSA-1650814.6 Collagen biosynthesis and modifying enzymes 649 79709 5351 5352 8985 1297 7093 7092 1284 50509 1282 1286 1281 26577 1285 256076 169044 5118 1280 81578 255631 57642 5479 1310 340267 7373 136227 131873 91522 1296 1295 1294 1293 1292 1291 1290 1305 1303 1302 1301 1289 8974 1300 1288 283208 1287 85301 5033 1308 1307 84570 1306 10536 55214 64175 23127 140766 9508 9509 1278 1277 80781 10491 871 5034 1299 1298 ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME DATABASE ID RELEASE 95%5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 23081 474382 54145 23028 5585 10499 8970 8331 8337 128312 8334 8335 8370 55766 8968 8341 8342 8347 8348 94239 8345 3013 8340 8338 367 255626 3021 653604 354 3018 3017 85236 3014 3817 8349 KILLING MECHANISMS%REACTOME DATABASE ID RELEASE 95%9664420 Killing mechanisms 5879 10811 124056 1535 1857 1856 7474 8324 3725 1855 5599 27035 FASL CD95L SIGNALING%REACTOME DATABASE ID RELEASE 95%75157 FasL CD95L signaling 8772 843 355 356 841 SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME DATABASE ID RELEASE 95%4655427 SUMOylation of DNA methylation proteins 7341 6045 648 6015 7329 1912 1911 80012 57332 1789 84733 1788 1786 7703 8535 FRS-MEDIATED FGFR4 SIGNALING%REACTOME%R-HSA-5654712.5 FRS-mediated FGFR4 signaling 2251 8074 2249 2247 10818 2246 10817 152831 8823 8817 26281 9965 2264 5781 6654 4893 2254 3265 TRNA PROCESSING IN THE NUCLEUS%REACTOME%R-HSA-6784531.6 tRNA processing in the nucleus 51493 1478 10940 339487 283989 283742 29894 116461 10248 11260 1653 10978 79042 5901 79074 10799 10557 348995 9883 6396 10556 129401 9688 51637 57122 23225 4927 23165 8021 55746 55706 23636 9631 7175 9972 11097 23279 8086 51095 23511 53371 8480 79023 60528 79902 10762 5903 10898 79897 51367 11102 54913 10775 80746 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%R-HSA-901032.7 ER Quality Control Compartment (ERQC) 51009 6400 91445 6048 55741 7311 7314 6233 10956 80267 84447 10299 9695 10206 7316 56886 267 7844 11253 55757 11236 KETONE BODY CATABOLISM%REACTOME%R-HSA-77108.6 Ketone body catabolism 622 5019 64064 38 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 95%70263 Gluconeogenesis 2026 5230 5232 2597 387712 2023 226 229 26330 5105 2203 8789 92579 54020 57818 5106 5091 7167 5223 5224 230 2542 2538 2821 2027 CELLULAR RESPONSE TO STARVATION%REACTOME%R-HSA-9711097.5 Cellular response to starvation 6152 6155 6396 6154 6157 9349 6156 6159 6158 23521 51121 11224 6164 200916 6166 6122 6165 6124 6168 6123 6167 6169 6125 116832 25873 6160 6161 140801 4736 6130 6133 9045 6230 6232 6132 6210 6176 6231 6135 6234 6134 6235 6137 6191 6136 2197 6193 6171 6192 6170 6194 6173 6128 51065 6129 140032 6142 6205 6227 6141 6144 245972 6204 6143 245973 6207 6229 6146 6147 6206 6228 6181 155066 6139 6138 6209 9114 6208 27244 51606 6188 6187 6223 6201 6189 1386 6222 6203 9550 6224 523 6202 525 526 6218 527 6217 3921 528 529 8992 90423 127124 51382 57761 533 534 8894 1054 10312 1051 440 1965 389541 467 28956 468 9296 57521 1968 1649 55004 8649 10670 6009 64121 83667 64223 153129 6233 8131 2475 201163 55846 23334 58528 10542 440275 144577 10325 23677 84219 10641 81929 55364 6175 652968 96459 729438 79726 10985 154743 9681 57600 54468 11133 7311 INOSITOL TRANSPORTERS%REACTOME%R-HSA-429593.5 Inositol transporters 115584 114134 6526 KERATAN SULFATE KERATIN METABOLISM%REACTOME%R-HSA-1638074.4 Keratan sulfate keratin metabolism 2683 4060 11081 8534 23563 93010 4969 10678 2331 8703 2799 8704 8702 176 4166 11041 9435 4958 79369 5549 9334 9331 11046 2588 9469 10331 112937 3074 3073 10402 79411 6483 2720 6482 6484 6487 89944 BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME%R-HSA-9020265.2 Biosynthesis of aspirin-triggered D-series resolvins 4048 240 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 95%380284 Loss of proteins required for interphase microtubule organization from the centrosome 10383 10382 1781 1778 7846 5566 9793 7277 5518 9738 9662 7840 11064 22994 22995 7283 10733 80321 203068 55722 1454 1453 3320 55125 9814 11190 115106 79441 95681 1069 54801 983 10142 9702 10540 8655 5347 5108 11116 4751 55142 22897 54930 5116 79959 80184 93323 5577 23354 22981 8481 80254 121441 55755 23332 7532 10806 10121 7531 55559 8636 22919 11258 5048 84131 4957 55835 54820 TNFR1-INDUCED NF-KAPPA-B SIGNALING PATHWAY%REACTOME%R-HSA-5357956.5 TNFR1-induced NF-kappa-B signaling pathway 1540 8737 27005 329 3551 9099 257397 10133 6885 23118 330 7185 10399 7375 7186 7124 7128 8517 10616 56957 220213 8717 7132 55072 9825 10454 331 1147 81858 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME%R-HSA-399721.5 Glutamate binding, activation of AMPA receptors and synaptic plasticity 80852 2036 27092 7102 23426 4905 9495 4646 5582 10369 5579 10368 59283 2892 2891 2893 2890 1742 1739 815 5578 816 9463 817 818 160 4193 INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME DATABASE ID RELEASE 95%6785807 Interleukin-4 and Interleukin-13 signaling 7076 301 7040 7431 4312 4843 4313 2208 6772 5443 4170 7157 7184 5292 7133 356 2625 9655 2335 1901 3320 3552 3911 5743 3553 3934 4582 3565 7124 3596 1052 6778 3569 3570 3606 6774 6288 8651 6356 6097 6347 3383 595 3662 3687 2247 6095 1026 6935 6367 5295 3688 2308 7412 332 4609 3684 3576 58480 5451 948 3091 4988 3312 3689 3162 7422 3605 112744 3717 3929 3561 3716 4318 7291 207 7297 240 6657 3593 3592 246 3586 4692 10538 596 3598 3597 6624 598 79923 149233 4985 3082 51561 3566 3976 5008 604 9021 4314 1278 2353 4128 3726 2162 2309 3718 SMAC(DIABLO)-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME DATABASE ID RELEASE 95%111464 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 331 840 842 317 836 54205 56616 PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME%R-HSA-1483196.4 PI and PC transport between ER and Golgi membranes 23760 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 95%187706 Signalling to p38 via RIT and RIN 673 6014 4803 6016 4914 VIRAL MESSENGER RNA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%168325 Viral Messenger RNA Synthesis 23636 9631 7175 9972 2963 11097 2962 23279 8086 5434 23511 5435 53371 5436 8480 5437 79023 5438 79902 5439 10762 5903 5430 5431 5432 5433 348995 9883 6396 129401 9688 57122 23225 5440 4927 5441 23165 55746 8021 55706 METABOLISM OF STEROIDS%REACTOME DATABASE ID RELEASE 95%8957322 Metabolism of steroids 51588 1718 213 1583 1582 1581 10498 51478 28234 3638 8720 412 80765 26031 5443 1593 1081 1589 1588 1585 1109 10948 10998 147323 83930 9871 9632 5465 1586 10427 706 112812 2232 9256 2230 134429 123264 10858 5469 1646 1645 6718 9023 403313 7421 6715 64801 6716 3837 22937 5641 80270 50814 2638 114876 114880 441282 79071 3972 114881 2194 114883 866 57678 51144 11001 31 6770 6256 51141 3293 6604 23600 200931 8714 6319 2172 6555 6907 6554 8648 79718 3284 3283 6307 3291 1594 3290 1591 3294 51171 120227 23054 8309 3292 51170 4036 7329 5901 9971 10005 6613 6579 10682 5007 91734 231 3295 1584 10802 80205 10484 4597 85441 10499 96764 8644 9885 570 51302 2224 6720 1387 2222 6667 3157 8647 1595 6721 1717 10654 6309 39 9453 4047 4520 3422 4598 6713 7108 3930 4800 26119 4801 51360 9420 4802 51128 10599 32 8029 79644 BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME%R-HSA-9026762.2 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) 2948 4056 DISEASES OF NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 95%9735804 Diseases of nucleotide metabolism 3251 100 353 4860 DEFECTIVE SFTPA2 CAUSES IPF%REACTOME%R-HSA-5687868.4 Defective SFTPA2 causes IPF 729238 SIGNALING BY WNT IN CANCER%REACTOME DATABASE ID RELEASE 95%4791275 Signaling by WNT in cancer 54894 4040 22943 1499 4041 89780 1488 1487 6934 27121 79412 83999 27123 80351 5519 8325 64840 5515 7855 5516 5518 8322 8323 5525 5526 8312 2932 5527 324 5528 1452 5529 8658 139285 ENOS ACTIVATION%REACTOME%R-HSA-203615.6 eNOS activation 3320 23576 114757 10434 340481 6697 207 808 857 80777 4846 4836 9397 GLYCOPROTEIN HORMONES%REACTOME DATABASE ID RELEASE 95%209822 Glycoprotein hormones 3972 3626 7252 3625 3624 3623 2488 94115 83729 1081 EGFR DOWNREGULATION%REACTOME DATABASE ID RELEASE 95%182971 EGFR downregulation 8874 6456 6455 1950 2060 867 6457 1956 9146 10254 5782 8027 374 10253 998 7311 7314 6233 29924 7039 58513 10252 685 5774 5796 255324 2069 7316 1839 30011 COMPLEX I BIOGENESIS%REACTOME DATABASE ID RELEASE 95%6799198 Complex I biogenesis 51295 55967 5018 150274 55744 55863 4722 54539 91942 28976 4728 4729 4720 90871 4723 4724 4725 29078 4726 4706 25915 137682 55572 4731 4705 4707 100996939 4708 4709 4700 4701 4702 55101 4704 51300 4716 374291 4717 4718 4719 51079 3313 4710 4711 4712 4713 4698 55471 4715 119559 4540 4541 4535 84233 4536 4537 4538 25880 80224 51103 284184 4694 4695 4696 79133 57226 4714 126328 MITOCHONDRIAL UNCOUPLING%REACTOME DATABASE ID RELEASE 95%166187 Mitochondrial Uncoupling 9481 7352 291 7351 7350 148811 9016 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME DATABASE ID RELEASE 95%2644605 FBXW7 Mutants and NOTCH1 in Cancer 9978 4851 6500 8454 RAC2 GTPASE CYCLE%REACTOME%R-HSA-9013404.2 RAC2 GTPase cycle 29 11135 1969 10006 55914 9217 4168 7074 5295 3688 5296 5290 55004 1795 1794 1793 5880 7444 2909 9743 57584 392 9341 5062 8826 1536 50619 1535 4580 9815 7879 55845 4688 4689 10298 3998 9710 396 81839 23092 55971 143872 5338 1829 4810 55619 85360 10424 10787 10152 8503 998 7204 9732 2010 25813 23344 23580 143098 29127 57580 4983 613 857 8987 3930 55789 10451 51347 7410 26050 3071 4162 7112 7037 23141 5058 10163 28964 80728 7409 23191 653361 81624 23592 23075 55114 51566 TRANSCRIPTIONAL REGULATION BY NPAS4%REACTOME%R-HSA-9634815.4 Transcriptional Regulation by NPAS4 146713 341359 1020 10769 405 406 2908 10135 8851 266743 1387 6722 5978 4343 2669 5979 192669 3630 23112 27327 30818 26523 192670 27161 5594 57690 5595 627 2353 7514 440073 9915 4193 DEFECTIVE GALNT12 CAUSES CRCS1%REACTOME%R-HSA-5083636.4 Defective GALNT12 causes CRCS1 727897 10071 94025 143662 140453 79695 4588 118430 4589 283463 394263 4582 4583 4584 4585 4586 200958 56667 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME%R-HSA-156584.7 Cytosolic sulfonation of small molecules 6822 6818 54928 10380 6783 391365 25830 6817 84836 8459 8460 6819 27284 445329 27233 6799 50512 ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%9018519 Estrogen-dependent gene expression 10498 3727 2354 1655 3276 8850 2625 3320 5469 7528 5241 200845 2099 8970 8331 8337 8243 9126 128312 2958 8334 2957 8335 2033 10735 8370 55766 5885 8968 10274 4602 51523 8341 1105 8342 57678 8347 7764 8348 1386 94239 7090 8345 3169 3013 9166 8340 9687 1509 7033 8338 7392 255626 7031 3021 653604 3018 2288 3017 85236 3014 23030 8349 474382 10728 54145 3065 4435 861 865 595 23028 3326 8648 6908 7391 8204 4609 4343 192669 23112 27327 26523 6387 192670 8202 27161 57690 5451 8312 5440 5441 2494 23189 2963 2962 5434 5435 5436 5437 5438 5439 5430 5431 5432 5433 10499 596 1025 1387 904 6667 3838 7039 2353 10524 3725 TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME%R-HSA-190872.3 Transport of connexons to the plasma membrane 2697 2706 INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION%REACTOME DATABASE ID RELEASE 95%168273 Influenza Viral RNA Transcription and Replication 5611 348995 9883 6152 6155 6396 6154 129401 6157 9688 9349 6156 57122 6159 6158 23521 23225 51121 11224 4927 6164 3843 23165 200916 6166 6122 55746 6165 55706 6124 23636 9631 6168 7175 6123 3320 6167 9972 6169 11097 6125 23279 116832 8086 25873 23511 6160 53371 6161 8480 140801 79023 4736 142 79902 10762 6130 6133 5903 9045 6230 6232 6132 6210 6176 6231 6135 6234 6134 6235 6137 6191 6136 2197 6193 6171 6192 6170 6194 6173 6128 51065 6129 140032 6142 6205 6227 6141 6144 6204 6143 6207 6229 6146 6147 6206 6228 6181 6139 6138 6209 6208 6188 6187 6223 6201 6189 6222 6203 6224 6202 6218 6217 3921 6233 6175 5440 5441 8021 2963 2962 5434 5435 5436 5437 5438 5439 5430 5431 5432 5433 7311 2926 2-LTR CIRCLE FORMATION%REACTOME DATABASE ID RELEASE 95%164843 2-LTR circle formation 2547 7520 3981 3159 7518 11168 8815 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME%R-HSA-379726.3 Mitochondrial tRNA aminoacylation 23395 25973 2617 79731 92935 124454 57038 51067 57176 80222 5859 55157 79587 57505 10667 55699 3735 27068 54938 10352 23438 MET ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 95%8875791 MET activates STAT3 4233 6774 3082 VARIANT SLC6A20 CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME DATABASE ID RELEASE 95%5660686 Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) 54716 SIGNALING BY FLT3 ITD AND TKD MUTANTS%REACTOME DATABASE ID RELEASE 95%9703648 Signaling by FLT3 ITD and TKD mutants 9846 5292 6776 1026 50507 2322 2885 5295 5781 6654 598 4893 5290 6777 3265 DIGESTION%REACTOME DATABASE ID RELEASE 95%8935690 Digestion 11181 8513 8544 2980 280 119548 27159 278 279 8972 2984 1056 2981 5407 3938 5406 5408 6476 1208 1118 248 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME DATABASE ID RELEASE 95%983231 Factors involved in megakaryocyte development and platelet production 3705 23186 11127 7465 5566 5567 10938 5568 55604 221037 8165 10362 25970 51317 11216 3046 3045 81928 23764 23414 3048 3047 50808 30846 30845 64780 140628 7157 10019 139818 2625 832 25 3660 3659 5868 1062 5573 5575 5576 85440 5577 9493 81704 998 23348 9732 2624 8968 4602 10112 57572 9585 23046 24137 3021 4097 830 653604 26153 55605 22920 3065 25942 55614 146909 23028 81930 1017 84643 55582 3796 23303 80005 5879 9371 221458 3442 3441 547 3440 11311 3452 3066 3451 23468 11004 55083 3798 3799 3449 3448 3447 9927 3446 1795 3445 1794 1793 55669 113220 3444 3797 3443 3832 3833 3834 3456 3835 64837 90990 89953 285643 10603 147700 3717 3831 23095 10749 1020 124602 56992 64147 55619 829 91768 7975 2627 29127 4778 2623 64145 5890 3043 2626 161882 5889 LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME%R-HSA-8853383.2 Lysosomal oligosaccharide catabolism 23324 4125 4126 4123 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH2%REACTOME DATABASE ID RELEASE 95%5632928 Defective Mismatch Repair Associated With MSH2 2956 4436 4437 SIGNALING BY FGFR3 IN DISEASE%REACTOME DATABASE ID RELEASE 95%5655332 Signaling by FGFR3 in disease 8074 5335 2549 2249 2247 10818 2246 8823 8817 5295 26281 6654 4893 5290 2261 2254 3265 INTRACELLULAR METABOLISM OF FATTY ACIDS REGULATES INSULIN SECRETION%REACTOME%R-HSA-434313.6 Intracellular metabolism of fatty acids regulates insulin secretion 2182 2181 948 DISEASES OF HEMOSTASIS%REACTOME%R-HSA-9671793.6 Diseases of hemostasis 2147 2158 7450 2161 2811 2160 2812 2157 3818 8459 8460 2815 710 2814 2677 11093 2159 SIGNALING BY ACTIVIN%REACTOME%R-HSA-1502540.5 Signaling by Activin 130399 91 7049 92 93 4087 8928 4088 10589 10468 4089 3625 5594 3624 5595 10272 3623 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME%R-HSA-8939236.2 RUNX1 regulates transcription of genes involved in differentiation of HSCs 474382 54145 861 865 10413 9861 6929 6233 2625 7316 10213 25 4331 1022 5706 6938 5707 5708 5709 83737 5700 5701 5702 5704 5705 5682 5683 5684 5685 902 5686 5717 5718 8970 5719 8331 4297 4004 8337 128312 11047 8334 8335 4005 5713 5714 5690 8370 5691 2624 5692 55766 8861 5693 8968 5694 4602 7311 7979 5695 8341 7314 2623 8342 8347 8348 94239 8345 5687 3013 5688 8340 5689 8338 7161 255626 3021 653604 3018 3017 85236 3014 6886 6688 8349 SEROTONIN RECEPTORS%REACTOME%R-HSA-390666.5 Serotonin receptors 3361 3360 3354 3352 3358 3357 3351 3356 3350 3355 3363 3362 SIGNALLING TO RAS%REACTOME%R-HSA-167044.6 Signalling to RAS 5899 25759 4803 5898 6300 5603 53358 4914 5900 9261 5600 7867 6464 1432 6654 4893 3265 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME%R-HSA-168138.6 Toll Like Receptor 9 (TLR9) Cascade 121260 6885 7186 7189 79155 7157 7335 3665 10454 64127 929 8945 5970 353376 841 7334 148022 8517 3146 23643 5594 5595 30849 1386 7099 57162 5604 5598 51231 1849 84166 5289 1147 1848 6285 1846 6288 1845 92610 6283 51295 51135 4214 9684 4793 28512 57161 79671 3551 177 4615 121457 246330 5599 28511 3656 257397 23118 1326 5609 466 80216 6416 4208 5601 7867 5602 5606 5519 54106 5515 5516 5518 6233 8767 3654 9261 7316 5528 4791 5608 9097 23291 11274 1432 4792 8411 10392 7311 80231 6197 3663 7314 6196 351 4790 64145 9252 6195 8454 4205 2353 5600 2002 6500 3725 51284 DEFECTIVE MAOA CAUSES BRUNS%REACTOME%R-HSA-5579012.4 Defective MAOA causes BRUNS 4128 SLC-MEDIATED TRANSPORT OF NEUROTRANSMITTERS%REACTOME%R-HSA-442660.4 SLC-mediated transport of neurotransmitters 6540 6580 9152 6534 57084 57030 6536 83733 140679 6538 55117 6529 6531 6530 11254 79751 54716 246213 6532 340024 6582 DEFECTIVE CYP11A1 CAUSES AICSR%REACTOME DATABASE ID RELEASE 95%5579026 Defective CYP11A1 causes AICSR 1583 112812 2232 2230 RUNX3 REGULATES BCL2L11 (BIM) TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%8952158 RUNX3 regulates BCL2L11 (BIM) transcription 2309 4088 4089 864 10018 ANCHORING FIBRIL FORMATION%REACTOME%R-HSA-2214320.5 Anchoring fibril formation 3918 1294 649 3909 3914 7093 7092 TRANSLESION SYNTHESIS BY POLI%REACTOME%R-HSA-5656121.2 Translesion synthesis by POLI 7311 5111 7314 11201 5980 6233 10459 51455 5981 5982 6117 5984 7316 5983 5985 6119 6118 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME DATABASE ID RELEASE 95%176407 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase 8881 64682 25906 11065 8697 7324 10393 29945 27338 119504 29882 246184 996 51343 51434 51433 8556 991 51529 7321 COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 95%6811434 COPI-dependent Golgi-to-ER retrograde traffic 55850 10945 63908 51014 55614 146909 11127 81930 84643 55582 3796 23423 23303 372 4905 381 10959 9371 221458 662 8729 547 11004 55083 3798 3799 378 113220 3797 3832 26286 10972 3833 3834 6836 3835 64837 90990 9276 89953 285643 147700 375 11316 3831 23095 10749 60561 22818 1314 124602 54732 56992 9183 84364 51226 1062 53407 64147 22820 377 51594 11014 1315 81876 9493 5861 10112 29127 9554 26958 9585 8774 8775 23046 24137 11015 55738 26153 55605 22920 NON-CODING RNA METABOLISM%REACTOME DATABASE ID RELEASE 95%194441 Non-coding RNA Metabolism 10419 79760 6607 79833 11218 25929 54960 348995 9883 6396 129401 8487 9688 57122 50628 23225 4927 23165 8021 55746 55706 23636 9631 7175 9972 11097 23279 8086 23511 53371 8480 79023 79902 10762 5903 22916 4686 96764 6632 6628 51808 6634 6633 6636 6635 10073 1207 6637 79084 HCMV INFECTION%REACTOME%R-HSA-9609646.5 HCMV Infection 2146 55048 89853 5371 137492 27183 5928 51271 51160 155382 93343 7251 79720 5931 221613 84313 51028 11267 5119 348995 10951 9883 6396 129401 92815 9688 8969 79643 57122 51652 8726 23225 440689 4927 23165 55746 55706 23636 9631 91782 7175 9972 11097 23279 1956 8086 92421 23511 53371 8480 79023 3190 79902 10762 5903 8655 1616 27243 8970 8331 128866 8337 128312 8334 29082 8335 8370 25978 1052 8968 8341 8342 8347 8348 8345 3013 8340 51143 8338 255626 653604 3018 3017 85236 8349 1781 1780 1778 6907 79718 1783 9612 3688 8841 9611 2874 140735 23512 10155 8021 317772 4790 85235 2002 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN WNT SIGNALING%REACTOME DATABASE ID RELEASE 95%8939256 RUNX1 regulates transcription of genes involved in WNT signaling 8312 84870 861 865 50943 2099 ACETYLATION%REACTOME%R-HSA-156582.4 Acetylation 9 10 REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME%R-HSA-6806003.4 Regulation of TP53 Expression and Degradation 253260 1029 6446 207 639 1017 9099 983 1616 900 472 5519 7157 5170 55615 5515 7311 7874 5516 64223 7314 117584 5518 51230 6233 2475 208 10000 5527 7316 80196 890 8900 11200 4194 79109 4193 PURINE CATABOLISM%REACTOME%R-HSA-74259.8 Purine catabolism 7498 4907 4860 131870 84618 22978 11164 30833 10591 55270 93034 3704 56985 9615 MAPK FAMILY SIGNALING CASCADES%REACTOME%R-HSA-5683057.5 MAPK family signaling cascades 6708 6710 5623 5894 6712 5906 5908 5566 64096 5567 5568 10125 5786 5593 25759 6300 53358 5900 57731 8555 8682 8437 2335 10642 221002 51332 7010 284 2118 5863 152559 2339 51104 10156 9693 6709 22821 115727 1844 1843 153090 4902 989 1847 5896 5897 54756 9048 8831 84292 57139 5778 81926 5596 5597 3562 64926 3559 58489 5156 3558 5922 5979 23463 3569 3815 3337 1839 1849 1848 1846 8997 4233 51125 5879 5924 28956 51114 2308 4609 8649 4343 192669 23112 27327 26523 9986 192670 27161 57690 9861 6233 9978 3315 7316 7514 10213 5062 5706 3716 5707 5708 2064 5709 5700 7297 5701 23179 5702 7529 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 5690 5691 5692 5693 5694 84078 7311 5695 7314 5687 5688 5689 5058 80824 5588 402 8452 161742 4763 22808 399473 11221 408 409 200734 4296 25780 1852 1850 8036 5923 3563 3560 6711 1439 1438 3568 3567 2342 8826 1950 1956 5063 896 377630 5536 148170 5921 5781 4893 27006 998 5159 10435 8660 9542 10718 145957 5594 5595 10818 10602 3570 3690 4684 3674 8817 5604 26281 5147 5605 9965 6654 8550 2254 3265 2252 2251 8074 2249 2248 2247 2246 2323 9462 2322 152831 8823 5295 5501 5296 6464 2264 5519 5290 5291 2255 3667 5515 8202 5516 3845 808 5518 88 3084 1742 1741 1437 1740 2906 5525 5526 1739 815 5527 2904 5528 5500 5529 6714 816 4747 2902 817 8315 818 5245 3717 3561 673 2244 2266 7414 8844 10256 54518 22866 4140 7450 5037 2243 10048 7094 983 1445 369 283455 10817 374 2534 598 3082 10434 7979 7039 685 5155 5774 255324 2069 2309 8556 5747 2668 3725 2676 2675 3718 2674 UB-SPECIFIC PROCESSING PROTEASES%REACTOME DATABASE ID RELEASE 95%5689880 Ub-specific processing proteases 9100 9101 25862 100287513 7046 27005 23326 90865 55288 993 401447 10254 645836 6881 6885 55611 57599 5423 408 80351 409 1080 7186 7189 7157 100287178 29761 10474 7874 221613 1643 9804 645402 8975 8295 2625 92815 8724 10454 8969 8607 9817 219333 440689 100287144 84749 23770 1540 8737 6314 329 91833 51616 84196 9960 9146 8078 64135 377630 6502 728419 63967 330 9958 7417 8970 7416 8331 7419 991 2648 8337 128312 8334 100287364 8335 27430 8517 8341 8342 8347 8348 8345 3013 8340 8338 255626 3018 3017 85236 8349 3416 4609 9986 6478 100287238 100287478 9861 81847 6233 9738 9736 728386 3091 8312 367 7316 51651 9868 8658 4194 10213 8678 8313 4193 5706 57646 5707 84101 5708 4086 63891 5709 7353 4087 4088 100287327 4089 5700 100287205 5701 9099 5702 9097 100287441 5728 5704 23032 5705 64750 5682 5683 100288520 5684 5685 4092 5686 154 5717 7375 5718 392188 5719 93624 11274 11047 10868 5713 10869 5714 5690 5691 5692 5693 4792 5694 317772 7311 7979 5695 23586 79594 7314 85235 4303 5687 5688 5689 100287404 64426 55031 23358 83844 890 8900 57695 79589 84132 8239 10600 POU5F1 (OCT4), SOX2, NANOG REPRESS GENES RELATED TO DIFFERENTIATION%REACTOME%R-HSA-2892245.2 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 5460 79923 6657 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%R-HSA-1296065.4 Inwardly rectifying K+ channels 3772 55970 3762 3763 3765 3766 3768 54331 59345 3758 3770 2793 2792 3773 2791 2790 2788 2782 2787 2786 2785 2784 2783 51764 10681 9568 94235 10060 3760 3764 3761 6833 2550 3767 3759 PTK6 EXPRESSION%REACTOME%R-HSA-8849473.2 PTK6 Expression 3091 27043 2908 5753 2034 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME%R-HSA-72702.5 Ribosomal scanning and start codon recognition 8894 8662 1965 8663 8661 8666 1975 8667 8664 1968 8665 27335 3646 51386 7458 8668 1977 8669 10480 1964 6233 1981 6230 6232 6210 6231 6234 6235 6191 2197 6193 6192 6194 51065 140032 6205 6227 1983 6204 6207 6229 6206 1974 6228 1973 6209 6208 6188 6187 6223 6201 6189 6222 6203 6224 6202 6218 6217 3921 HYALURONAN METABOLISM%REACTOME%R-HSA-2142845.4 Hyaluronan metabolism 55576 57214 3036 6677 10894 26503 2990 23553 960 3373 8372 3074 3073 6548 3161 10057 11261 8692 3038 3037 FORMATION OF THE URETERIC BUD%REACTOME DATABASE ID RELEASE 95%9830674 Formation of the ureteric bud 7481 5979 5076 6495 6299 2296 652 9353 3207 10736 6092 255743 2303 3227 3237 26585 3688 2668 2138 8516 2674 ASPARTATE AND ASPARAGINE METABOLISM%REACTOME DATABASE ID RELEASE 95%8963693 Aspartate and asparagine metabolism 443 339896 2346 339983 10165 10003 374569 440 2806 8604 2805 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME%R-HSA-389887.5 Beta-oxidation of pristanoyl-CoA 10005 8310 1384 55289 3295 54677 23600 8309 DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM%REACTOME%R-HSA-3560782.5 Diseases associated with glycosaminoglycan metabolism 9060 2683 4060 11081 26229 375790 2131 4969 2331 176 4166 3339 1836 4958 5549 6383 221914 9672 10082 6385 22856 2262 6382 2239 2719 2817 1462 9469 113189 3074 3073 63827 1634 11285 126792 633 1464 6487 1463 10675 RAF MAP KINASE CASCADE%REACTOME%R-HSA-5673001.12 RAF MAP kinase cascade 6708 6710 5623 5894 6712 5906 5908 64096 10125 5786 5593 25759 6300 53358 5900 57731 8682 8437 2335 221002 51332 7010 284 5863 152559 2339 51104 10156 9693 6709 22821 115727 1844 1843 153090 4902 1847 54756 9048 8831 84292 57139 5778 81926 3562 64926 3559 58489 5156 3558 5922 5979 23463 3815 1839 1849 1848 1846 4233 51125 5924 28956 51114 8649 9986 9861 6233 9978 7316 10213 5706 3716 5707 5708 2064 5709 5700 5701 23179 5702 7529 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 5690 5691 5692 5693 5694 84078 7311 5695 7314 5687 5688 5689 80824 5588 402 8452 161742 4763 22808 399473 11221 408 409 200734 4296 25780 1852 1850 8036 5923 3563 3560 6711 1439 1438 3568 3567 2342 8826 1950 1956 377630 5536 5921 4893 27006 5159 8660 9542 10718 145957 5594 5595 10818 3690 4684 3674 8817 5604 26281 5147 5605 9965 6654 2254 3265 2252 2251 8074 2249 2248 2247 2246 2323 9462 2322 152831 8823 5295 5501 5296 6464 2264 5519 5290 5291 2255 3667 5515 5516 3845 808 5518 88 3084 1742 1741 1437 1740 2906 5525 5526 1739 815 5527 2904 5528 5500 5529 6714 816 4747 2902 817 8315 818 5245 3717 3561 673 2244 2266 7414 8844 10256 54518 22866 4140 7450 5037 2243 10048 7094 1445 369 283455 10817 374 2534 598 3082 10434 7979 7039 685 5155 5774 255324 2069 5747 2668 2676 2675 3718 2674 NEUROTRANSMITTER CLEARANCE%REACTOME%R-HSA-112311.7 Neurotransmitter clearance 4128 590 217 220074 1312 6580 6532 43 6531 6582 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME%R-HSA-162658.3 Golgi Cisternae Pericentriolar Stack Reorganization 81876 5861 5862 2801 26003 5594 891 64689 983 5347 9133 8615 8548 BIOSYNTHESIS OF MARESINS%REACTOME DATABASE ID RELEASE 95%9018682 Biosynthesis of maresins 1544 1576 1571 1565 2053 1559 240 1558 ESTROGEN-STIMULATED SIGNALING THROUGH PRKCZ%REACTOME DATABASE ID RELEASE 95%9634635 Estrogen-stimulated signaling through PRKCZ 5590 5594 4893 3265 5170 SARS-COV-2 INFECTION%REACTOME DATABASE ID RELEASE 95%9694516 SARS-CoV-2 Infection 3454 59272 1655 143 2931 56965 83666 84875 79668 7097 54956 7096 54625 9871 9632 7335 9641 3665 10427 79643 51652 91782 23479 92421 26276 6230 6210 6231 6234 6235 6191 22863 2197 7334 6193 6192 6194 27243 51065 128866 140032 6205 6227 6204 10971 29082 6207 6229 6206 6228 25978 6209 6208 6188 6187 6223 6201 6189 6222 6203 6224 6202 6218 6217 3921 51311 84061 11282 7841 29801 25921 253832 51201 55741 1650 11320 3551 51125 4247 51304 3326 3107 100128731 3106 4249 6185 7991 4124 4245 6184 25834 23193 58505 201595 6383 2530 221914 79844 821 11253 9672 5589 10082 51114 6385 746 1603 3703 2262 7341 6382 2239 3134 3133 2719 7329 2817 6233 8767 57506 3654 7316 9868 7428 8678 7534 8021 3135 3716 207 7297 10802 7529 10484 114548 3838 89122 10392 7311 23586 7532 7314 7531 857 7533 63982 203859 2589 7113 6733 57101 7706 5045 84282 338440 6885 3105 6772 567 7187 64398 7189 3661 340061 29110 3276 55107 5648 2697 81631 348995 80143 7405 9883 6396 129401 9688 10454 57122 55129 23225 50636 4927 64127 23165 55746 55706 23636 9631 3320 7175 196527 57719 9972 11097 23279 8086 23511 53371 8480 79023 79902 10762 64135 5903 6232 121601 7415 5925 5781 8517 30849 208 8829 6732 5289 1147 85437 375790 3656 257397 23118 3339 79760 91662 27072 84818 6607 3442 23339 5170 3441 9908 10146 3440 79833 11218 23765 6441 11311 3452 4153 3451 25929 3449 7555 3448 10207 3447 57617 64601 23367 3446 3445 26762 54960 3444 55823 3443 8487 7284 2932 65082 10610 3456 2810 1452 6483 92359 9636 50628 6482 26007 6484 3605 112744 6487 6480 256435 27090 1514 6632 1387 5777 7082 6628 6634 51128 6633 6636 10000 6635 6637 51284 6773 DEFECTIVE SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5619081.3 Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) 6531 SIGNALING BY NUCLEAR RECEPTORS%REACTOME DATABASE ID RELEASE 95%9006931 Signaling by Nuclear Receptors 5915 5916 3727 4313 4846 2354 1655 1903 2958 2957 2194 57678 1386 3480 1839 2288 23030 6319 10728 4435 3065 595 3326 6908 1592 340665 4609 56603 4343 192669 23112 27327 26523 192670 27161 57690 2289 7514 2100 5440 5441 4318 2963 2962 5434 5435 207 5436 5437 5438 5439 5430 10901 5431 5432 5433 2793 2792 2791 2790 3838 2788 2787 2786 2785 2784 2783 857 51764 94235 55970 10498 54331 5959 59345 2782 3276 10681 8850 8877 2625 6258 5467 3320 5469 1950 1956 7528 5241 200845 2099 1027 5536 5590 8970 8331 8337 8243 4893 9126 128312 8334 8335 8503 10735 2033 8370 5885 55766 10274 8968 4602 51523 340481 8341 1105 8342 5594 8347 55625 5595 8348 7764 94239 7090 8345 3169 3013 5481 9166 8340 9687 858 7033 1509 8338 7392 208 7031 255626 6256 4316 3021 653604 3018 3017 85236 3014 8349 3265 2171 5914 474382 54145 861 865 6257 23028 9682 2172 27329 6907 80820 8648 54659 79718 9619 64241 64240 7376 7391 9612 5295 10062 5296 8204 8841 9611 19 346562 1071 5290 221656 341 5170 344 29116 6722 2874 346 5166 347 348 5346 6387 5105 10123 8202 55818 808 5451 8312 5162 5163 5164 2771 5165 6714 2770 8050 5160 2494 5161 2773 23189 6801 1737 112724 10170 9249 8854 64577 1382 1381 57665 216 8608 51109 10499 8644 157506 374 220 596 124 1025 126 127 195814 1387 904 6667 1738 4314 7039 2353 685 127933 10524 255324 2069 2002 10000 2309 5747 3725 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-391903.3 Eicosanoid ligand-binding receptors 11251 5731 5732 5733 5734 5737 6915 1241 5739 10800 57105 165140 56413 5729 2840 C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME%R-HSA-5621481.3 C-type lectin receptors (CLRs) 5894 5566 5567 5568 6885 3710 7189 56667 7335 10454 3708 3709 8945 3553 5970 4775 5063 143662 841 118430 7334 4582 4583 4584 4585 4893 4586 200958 4772 2033 727897 5534 8517 10071 94025 5530 140453 5532 4588 4589 283463 394263 8915 26253 50856 10462 1147 93978 3265 3385 3384 3551 257397 2207 23118 997 9020 10892 84433 64170 5170 64581 5971 29108 808 5580 9861 6233 7322 4067 7316 10213 4791 30835 7321 5062 5706 338339 5707 5708 5709 5700 4773 5701 5702 5704 5705 5682 23291 5683 5684 5685 5686 5717 5718 5719 2534 6850 11047 1387 5713 5714 5690 5691 9039 5692 10768 5693 4792 5694 7311 7979 5695 7314 4790 9252 9040 8454 5687 5688 5689 170482 5058 6500 5336 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME%R-HSA-72706.4 GTP hydrolysis and joining of the 60S ribosomal subunit 6152 6155 6154 6157 9349 6156 6159 6158 23521 51121 11224 6164 200916 6166 6122 6165 6124 6168 6123 6167 6169 6125 116832 25873 6160 6161 140801 4736 6130 6133 9045 6230 6232 6132 6210 6176 6231 6135 6234 6134 6235 6137 6191 6136 2197 6193 6171 6192 6170 6194 6173 6128 51065 6129 140032 6142 6205 6227 6141 6144 6204 6143 6207 6229 6146 6147 6206 1974 6228 6181 1973 6139 6138 6209 6208 6188 6187 6223 6201 6189 6222 6203 6224 6202 6218 6217 3921 8894 8662 1965 8663 8661 8666 1975 8667 8664 1968 8665 27335 3646 51386 7458 8668 1977 8669 10480 1964 6233 6175 1981 9669 1983 7311 DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME DATABASE ID RELEASE 95%168928 DDX58 IFIH1-mediated induction of interferon-alpha beta 7706 4214 4793 28512 79671 3551 5300 177 3326 84282 28511 7187 7186 3442 7189 3441 3661 3440 29110 7318 3452 3451 3449 3448 7323 3447 6233 7322 3093 3446 3445 57506 80143 8772 3444 10010 3443 9246 9641 3665 7316 3456 9868 9636 26007 4791 7321 3320 1540 8737 83737 5970 55593 64135 5094 841 1387 2033 7128 89122 8517 4792 843 7311 3146 23586 7314 351 4790 9140 9474 51191 84166 1147 79132 6285 54476 6288 8887 6283 54941 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME%R-HSA-8939247.2 RUNX1 regulates transcription of genes involved in interleukin signaling 861 865 3977 3562 1997 CATECHOLAMINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%209905 Catecholamine biosynthesis 5409 7054 1644 1621 DEFECTIVE GGT1 CAUSES GLUTH%REACTOME%R-HSA-5579022.5 Defective GGT1 causes GLUTH 2678 RECYCLING OF BILE ACIDS AND SALTS%REACTOME%R-HSA-159418.6 Recycling of bile acids and salts 123264 8647 8714 213 10998 2172 6555 9971 6554 28234 8648 6256 10499 10599 80765 6579 570 200931 DEGRADATION OF GLI2 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 95%5610783 Degradation of GLI2 by the proteasome 5706 5707 5708 5709 5700 5566 5701 5567 5702 5568 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 2736 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 9861 8454 6233 5687 5688 9978 5689 2932 7316 1452 6500 10213 51684 8945 TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME%R-HSA-5669034.4 TNFs bind their physiological receptors 8771 128178 8995 970 1896 10913 4049 10673 939 8740 8600 8744 4982 7293 7292 3604 60401 23495 943 944 9966 8718 608 8764 7133 356 7132 8784 8741 TURBULENT (OSCILLATORY, DISTURBED) FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 95%9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells 7414 84290 3551 824 5970 826 302 2767 6772 3688 5520 5770 5519 10413 8517 4792 5515 2776 4790 5518 3690 9641 3685 9780 3678 5747 25 1147 DEFECTIVE UGT1A4 CAUSES HYPERBILIRUBINEMIA%REACTOME DATABASE ID RELEASE 95%5579016 Defective UGT1A4 causes hyperbilirubinemia 54657 GSK3B AND BTRC:CUL1-MEDIATED-DEGRADATION OF NFE2L2%REACTOME DATABASE ID RELEASE 95%9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 5706 5707 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 4780 11047 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 9861 8454 6233 5687 5688 9978 5689 2932 7316 6500 10213 8945 PEPTIDE CHAIN ELONGATION%REACTOME%R-HSA-156902.4 Peptide chain elongation 1938 6233 6152 6155 6154 6157 9349 6156 6159 6158 23521 51121 6175 11224 6164 200916 6166 6122 6165 6124 6168 6123 6167 6169 6125 116832 25873 6160 6161 140801 4736 6130 6133 9045 6230 6232 6132 6210 6176 6231 6135 6234 6134 6235 6137 6191 6136 2197 6193 6171 6192 6170 6194 6173 51065 6128 140032 6129 6205 6142 6227 6141 6204 6144 6207 6143 6229 6146 6206 6147 6228 6181 1915 6139 6209 6138 6208 6188 7311 6187 6223 6201 6189 6222 6203 6224 6202 6218 6217 3921 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%R-HSA-193692.2 Regulated proteolysis of p75NTR 83464 51107 6868 4804 4790 5970 5663 23385 7189 55851 5664 SIGNALING BY MRAS-COMPLEX MUTANTS%REACTOME%R-HSA-9660537.5 Signaling by MRAS-complex mutants 673 22808 5894 5500 5501 8036 7529 369 DEFECTIVE SLC35A3 CAUSES ARTHROGRYPOSIS, MENTAL RETARDATION, AND SEIZURES (AMRS)%REACTOME DATABASE ID RELEASE 95%5619083 Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS) 23443 DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 95%5607761 Dectin-1 mediated noncanonical NF-kB signaling 5706 5707 5708 5709 5700 5970 5701 5702 5704 5705 5682 5683 23291 5684 5685 5686 5717 5718 5719 9020 11047 5713 5714 5690 5971 5691 9039 5692 5693 5694 7311 7979 5695 7314 9040 9861 8454 6233 5687 5688 5689 7316 6500 4791 10213 1147 8945 REV-MEDIATED NUCLEAR EXPORT OF HIV RNA%REACTOME DATABASE ID RELEASE 95%165054 Rev-mediated nuclear export of HIV RNA 23636 9631 7175 9972 11097 23279 8086 23511 53371 8480 79023 1104 79902 10762 5903 5905 5902 5901 348995 9883 6396 129401 9688 57122 7514 23225 4927 23165 55746 8021 55706 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%R-HSA-456926.4 Thrombin signalling through proteinase activated receptors (PARs) 55970 10672 54331 2767 59345 408 2793 2792 409 2791 2769 2790 2147 2788 2782 2787 2786 2785 2776 2784 5594 2783 5595 51764 10681 2151 2149 2768 9630 94235 9002 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%R-HSA-927802.4 Nonsense-Mediated Decay (NMD) 10921 4116 22794 9939 6152 6155 6154 6157 9349 6156 6159 6158 23521 51121 11224 6164 65109 200916 6166 6122 6165 6124 6168 6123 6167 6169 6125 116832 25873 6160 6161 140801 4736 6130 6133 9045 6230 6232 6132 6210 6176 6231 6135 6234 6134 6235 6137 6191 6136 2197 6193 6171 6192 6170 6194 6173 6128 51065 6129 140032 6142 6205 6227 6141 6144 6204 6143 6207 6229 6146 6147 6206 6228 6181 6139 6138 6209 6208 6188 6187 6223 6201 6189 6222 6203 6224 6202 6218 6217 3921 9775 55110 5515 5518 6233 55802 6175 2107 23708 2935 1981 23049 23293 22916 9887 55181 4686 26019 23381 55629 5976 65110 56006 5520 7311 26986 DOWNREGULATION OF ERBB2 SIGNALING%REACTOME%R-HSA-8863795.3 Downregulation of ERBB2 signaling 11140 9101 3320 1950 2064 10193 55914 4145 1956 207 5782 26469 10273 8065 7311 9542 10718 7314 145957 6233 3084 685 2069 208 10000 7316 1839 SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 95%9006934 Signaling by Receptor Tyrosine Kinases 1759 7425 4192 3710 4846 1399 116 117 5899 25759 6014 6016 135 6300 5603 10126 53358 4914 5900 26052 57498 1398 3708 3709 1108 5867 9146 5782 14 5978 5771 26469 1386 10451 7410 5598 7409 51231 102 1849 4485 1848 5663 4486 1846 23385 1845 55851 5664 83464 8874 51107 8651 5879 4208 7074 55615 51741 2242 3091 4067 7006 1215 10076 10750 5440 2241 10603 5441 2064 4318 2963 2962 5898 5434 5435 5436 5437 5438 5439 5795 5430 5431 5432 5433 8851 10253 8569 238 5581 5579 10768 6197 6196 9252 6195 4205 3675 2670 7525 6696 9101 6446 10254 161742 8027 6868 581 200734 54845 8877 1003 253260 4690 2185 2099 23768 23769 53834 5140 5781 53916 4893 245972 245973 8503 27006 998 117145 3630 155066 2549 10273 9114 51606 8660 84951 5792 64759 5594 51072 5595 30849 10818 9550 523 525 526 1495 527 1509 208 3643 528 8440 8817 1500 529 26281 8992 387 9965 5289 26999 6654 90423 2254 222584 3265 2252 127124 2251 23545 8074 51382 3416 2249 2887 2248 2247 57761 2246 533 2323 534 10810 2322 152831 535 537 8823 10312 50617 5295 3688 5296 5770 6464 2264 5519 9296 5725 5290 5291 5170 63916 6722 2255 9846 54106 3667 5515 6387 5516 808 5518 2886 3084 1795 1742 1793 1729 5528 2904 6714 7422 2324 3791 7424 4670 7423 2277 2321 5228 29126 3717 3561 673 6776 5607 9402 8828 10048 1445 22916 25920 10817 4686 2534 3932 1111 3082 3481 3479 29924 58513 10252 1213 5774 5155 1211 5796 3718 160 30011 161 4916 4908 163 5906 5908 5566 5567 5568 7166 6236 2152 3399 4066 1175 8941 1173 8061 5340 3727 1785 3400 2354 10221 4664 4665 1959 23767 1958 3398 3397 23237 1961 1286 1960 1285 429 7049 256076 26018 10019 131873 9306 5829 1293 1292 1291 3913 3187 3914 1287 3185 3915 10319 3918 284217 3908 3909 10193 4145 3910 10755 3911 3912 3730 6692 3249 10653 3083 5156 3815 3178 8471 3480 8483 5753 1839 4233 8038 3065 25942 1499 81610 389658 10413 143282 80310 4609 10608 5764 23543 5327 558 285016 6461 4613 57610 9982 64223 4058 382 5580 11033 10188 6233 55824 80004 7059 2475 3925 9261 7060 3315 84985 7073 7072 83888 7316 9047 1447 5578 5800 5803 5062 6938 1536 1535 10458 207 55845 1020 4688 4689 7529 8936 1432 10787 10152 8065 7311 2889 7314 857 5600 3071 5058 10163 23191 79109 653361 5045 10006 5046 5125 55914 4803 639 9475 9844 6093 6772 23163 1284 1282 4734 2885 6777 11140 3320 1950 5335 867 1956 5241 5063 2591 9564 5590 3728 7058 5921 85440 200958 2033 5159 6778 9542 10718 145957 3690 3685 6774 8829 5604 5605 6285 1299 1298 2562 6456 2561 6455 2560 2060 6457 6678 2554 11059 23118 466 3673 7867 2567 1297 2566 8841 9611 5802 55879 348 3066 4209 7057 83737 374 5777 4915 4909 627 7039 2353 685 255324 3726 1786 2069 2002 10000 5747 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME DATABASE ID RELEASE 95%2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 9536 10728 5742 5743 873 1582 3248 5730 8644 5740 80142 127281 145482 6916 27306 ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME DATABASE ID RELEASE 95%114294 Activation, translocation and oligomerization of BAX 581 637 CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 95%5690714 CD22 mediated BCR regulation 5777 4067 973 974 933 ASPIRIN ADME%REACTOME DATABASE ID RELEASE 95%9749641 Aspirin ADME 590 1557 8714 6566 213 1559 682 10249 123876 341392 219970 92292 54659 54988 389396 1576 1066 1571 1565 348158 7363 8824 133688 7365 7364 7367 7366 54490 79799 54578 54577 54576 574537 54600 54658 1244 10864 54657 54579 167127 1558 10941 10720 LOSS OF FUNCTION OF TP53 IN CANCER%REACTOME DATABASE ID RELEASE 95%9723907 Loss of Function of TP53 in Cancer 7157 INFLUENZA INFECTION%REACTOME%R-HSA-168255.6 Influenza Infection 5611 7040 348995 9883 6152 6155 6396 6154 129401 6157 9688 9349 6156 57122 6159 6158 293 23521 23225 51121 197259 3836 11224 4927 6164 3843 23165 200916 6166 6122 55746 6165 55706 6124 23636 9631 6168 7175 6123 3320 6167 9972 6169 11097 6125 23279 116832 8086 25873 23511 6160 53371 6161 8480 140801 79023 4736 142 79902 10762 6130 6133 811 3837 5903 9045 6230 6232 6132 6210 6176 6231 6135 6234 6134 6235 6137 6191 6136 2197 6193 6171 6192 6170 6194 6173 6128 51065 6129 140032 6142 6205 6227 6141 6144 6204 6143 6207 6229 6146 6147 6206 6228 6181 6139 6138 6209 6208 6188 6187 6223 6201 6189 6222 6203 6224 6202 6218 6217 3921 10898 3839 2633 402569 3840 3841 821 5610 5901 6233 8106 7514 9636 6175 5440 5441 8021 2963 2962 5434 5435 5436 5437 5438 5439 5430 5431 5432 5433 3838 7311 3304 1213 1211 2926 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%R-HSA-3858494.5 Beta-catenin independent WNT signaling 163 55970 6885 1175 54331 1173 3710 59345 409 5593 2782 10681 5880 3708 3709 50855 57216 1855 5145 4772 7481 5534 5592 1857 5158 1856 5148 7976 7855 51701 8322 5330 5331 5530 23513 8323 5532 2780 23236 2535 2775 387 23002 83439 1499 51176 5216 6932 6934 5879 144165 1212 4920 8321 4343 8325 7471 192669 23112 81029 4919 27327 6259 26523 57154 192670 27161 808 57690 9861 6233 815 7316 5578 10213 5706 5707 5708 5709 5700 5701 5702 5704 5705 64750 5682 5683 5684 5685 5686 5717 5718 2793 5719 2792 2791 11047 2790 5582 5881 5713 5714 5579 5690 2788 5691 5692 2787 5693 2786 5694 54361 7311 2785 7979 5695 7314 2784 2783 51764 5687 5688 1213 5689 1211 7474 8324 94235 160 161 ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS%REACTOME DATABASE ID RELEASE 95%9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects 8881 64682 25906 11065 8697 7324 10393 29945 27338 119504 29882 246184 996 51343 51434 6502 51433 5925 51529 7321 DEFECTIVE SLC17A5 CAUSES SALLA DISEASE (SD) AND ISSD%REACTOME DATABASE ID RELEASE 95%5619035 Defective SLC17A5 causes Salla disease (SD) and ISSD 26503 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%R-HSA-948021.4 Transport to the Golgi and subsequent modification 6708 6710 6712 375056 10342 9334 10959 9331 1081 22872 8729 2804 6811 9871 378 9632 832 6396 1294 26286 57731 10427 6711 966 287 288 1604 51332 2801 2683 6709 1522 9486 8655 84364 58485 2517 1315 3972 3630 10113 9554 9570 26958 8774 8775 51143 55860 51164 11015 55738 830 10671 1639 93661 11282 23256 84516 10945 1781 63908 51014 1780 57511 11320 1778 4247 4249 23423 4124 51399 4245 372 25834 84342 91949 4121 1783 2530 4905 4122 381 51272 57134 9527 140735 22796 9382 2890 51046 10972 5537 6484 25839 79090 9276 22870 11070 4248 9117 11196 254263 375 81562 11316 1453 27095 83548 149111 6480 9919 89866 7109 10905 4253 6399 286 79694 10466 23243 2348 10175 126003 22818 25956 8703 10802 55014 10652 8704 51693 3998 8702 122553 1314 1075 10540 10484 64377 2525 54732 83696 90411 51226 10282 338596 26984 55291 79748 128637 374 10960 829 22820 377 11014 5265 81876 5861 2153 8128 10121 11258 64689 7039 51128 8615 2157 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 95%170968 Frs2-mediated activation 673 4803 2889 5906 1399 5604 5594 5605 5595 10818 7529 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 95%73728 RNA Polymerase I Promoter Opening 474382 54145 8970 8331 8932 8337 128312 8334 8335 7343 8370 55766 8968 8341 8342 5595 8347 8348 94239 8345 3013 8340 8338 255626 3021 653604 3018 3017 85236 3014 8349 FLT3 SIGNALING BY CBL MUTANTS%REACTOME DATABASE ID RELEASE 95%9706377 FLT3 signaling by CBL mutants 2322 7316 867 7311 7314 6233 2323 MATURATION OF HRSV A PROTEINS%REACTOME%R-HSA-9828806.1 Maturation of hRSV A proteins 23478 1459 60559 5045 1457 28972 90701 5499 3837 7514 5500 5501 1460 9789 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 83464 51107 3065 10013 10014 6907 79718 9734 6868 51564 3714 9612 8841 9611 23493 3516 4609 892 3066 9759 23462 8850 6233 3280 9978 79885 7316 55869 22938 55534 83933 9794 2648 1387 2033 28514 1024 182 7311 7314 84441 8454 9148 10046 54492 4851 142678 26508 388585 6500 57534 102 54567 5663 23385 55851 5664 STAT5 ACTIVATION%REACTOME DATABASE ID RELEASE 95%9645135 STAT5 Activation 2322 9846 6776 5781 2323 6777 NUCLEOTIDE SALVAGE DEFECTS%REACTOME DATABASE ID RELEASE 95%9734207 Nucleotide salvage defects 3251 100 353 TOXICITY OF BOTULINUM TOXIN TYPE E (BOTE)%REACTOME%R-HSA-5250992.4 Toxicity of botulinum toxin type E (botE) 6616 9899 9900 KIT MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 95%9669921 KIT mutants bind TKIs 3815 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME%R-HSA-5693567.4 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 51588 29086 51720 25 51548 10714 5424 5425 57804 5981 2072 63967 56655 7334 7336 8970 5426 5427 128312 79184 51426 8370 2067 54107 8341 8342 8347 8290 8348 6047 8345 8340 255626 3018 3017 85236 3014 8349 54145 348654 146956 197342 84464 9656 23514 80198 1017 79008 8924 7329 6233 6613 7316 165918 7468 7158 7486 5982 5883 5884 5983 116028 3364 472 5429 10635 54962 9025 672 151987 675 5893 84126 5531 1111 8914 83990 144715 63979 83695 51750 5810 7516 10111 5932 7517 7311 7979 4361 5111 7314 7156 5890 9156 5892 55732 84142 4683 11073 9577 580 10524 641 1763 545 6117 5984 890 5985 6119 8900 79728 5888 6118 80010 5889 DEFECTIVE DPM1 CAUSES CDG-1E%REACTOME DATABASE ID RELEASE 95%4717374 Defective DPM1 causes CDG-1e 8813 54344 8818 DEFECTIVE SLC5A7 CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME DATABASE ID RELEASE 95%5619114 Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) 60482 FORMATION OF THE CORNIFIED ENVELOPE%REACTOME%R-HSA-6809371.6 Formation of the cornified envelope 23254 353133 353135 5045 353137 5046 353139 26085 126638 353141 149018 353140 5266 353143 353142 1825 1824 1823 353145 353144 1041 23581 2125 11005 147409 9333 5652 340654 643414 643418 43847 43849 7051 199834 404203 7062 64065 6768 11202 5318 11187 643394 4014 26239 84648 823 2312 826 3713 63036 1828 1832 1830 1829 3728 448835 8502 1475 6698 5317 142910 254910 5493 25818 6699 6707 353132 353131 6700 6701 6704 6703 6706 6705 353134 PHASE II - CONJUGATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 95%156580 Phase II - Conjugation of compounds 1312 8459 8460 2948 9 10 4548 1544 6822 2950 10249 123876 341392 219970 92292 54988 389396 23169 11046 27306 27430 2938 2940 7363 133688 7365 6818 7364 7367 7366 7360 54490 80146 79799 54578 54577 55347 54576 10327 574537 54575 54658 54657 54579 7358 167127 10941 10720 54659 79094 116285 348158 4552 51504 9446 29104 2678 191 124975 2687 79017 2730 2686 494143 2954 55748 26873 2729 4257 2937 4258 4259 4143 373156 2939 4837 2944 2941 2949 2947 2946 7172 2953 2952 57412 4144 221357 119391 2098 653689 54928 10380 6783 391365 25830 6817 84836 54600 6819 27284 445329 27233 6799 50512 ACTIVATION OF HOX GENES DURING DIFFERENTIATION%REACTOME%R-HSA-5619507.5 Activation of HOX genes during differentiation 5915 5914 5916 474382 2146 9125 84661 54145 11091 5928 5929 8841 9611 1959 23054 22976 5931 8202 23512 9070 84962 7703 3199 8726 79447 8085 5440 5441 57472 7528 5434 5435 5436 5437 5438 5439 5430 5431 5432 5433 58508 8970 8331 8337 128312 1387 8334 8335 2033 8370 55766 8968 8341 8342 8347 8348 94239 4211 8345 3200 3013 9063 5087 9935 8340 3211 3201 7403 8338 10664 255626 3221 6256 63925 3214 3021 3213 653604 3212 3725 3018 5316 3017 3233 85236 3232 3014 3198 3231 5080 8349 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%R-HSA-2129379.3 Molecules associated with elastic fibres 655 3693 3694 7448 7040 3688 8516 650 4052 4054 2199 27302 8076 2192 10516 652 2202 3696 30008 8200 3690 8425 3685 4237 4238 4239 7043 7042 RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 95%5213460 RIPK1-mediated regulated necrosis 8797 6386 11140 3320 8737 329 83737 841 11035 330 5071 7186 10015 8473 10273 355 7311 356 8717 7314 10211 6233 8743 8772 57162 7332 7316 331 197259 2319 8795 ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME%R-HSA-5620912.4 Anchoring of the basal body to the plasma membrane 57787 10383 57545 10382 26005 1781 261734 79600 26123 51134 51259 1778 54806 4735 7846 84902 5566 4867 132320 9657 54903 91147 146057 27077 9793 85302 79867 7277 117177 5518 9738 8766 9662 7840 11064 22994 79598 22995 7283 10733 80321 203068 55722 1454 1453 3320 55125 9814 11190 115106 79441 95681 1069 54801 983 10142 9702 10540 8655 5347 5108 11116 4218 4751 55142 22897 54930 5116 79959 80184 93323 5577 23354 22981 8481 80254 121441 55755 23332 7532 10806 10121 7531 55559 8636 22919 11258 5048 84131 4957 55835 23322 54820 347240 80776 22832 TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME DATABASE ID RELEASE 95%9033500 TYSND1 cleaves peroxisomal proteins 51 219743 6342 5264 8540 3295 30 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%111447 Activation of BAD and translocation to mitochondria 5534 572 7532 637 207 7531 7533 7529 208 10000 2810 596 5533 7534 10971 DEFECTIVE MOGS CAUSES CDG-2B%REACTOME DATABASE ID RELEASE 95%4793954 Defective MOGS causes CDG-2b 7841 STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS%REACTOME%R-HSA-9702518.2 STAT5 activation downstream of FLT3 ITD mutants 2322 9846 2885 6776 5292 5781 1026 598 6777 50507 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 95%1855183 Synthesis of IP2, IP, and Ins in the cytosol 4952 8821 51477 3628 8867 9108 66036 3631 55586 3613 3612 3632 3633 27124 CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME%R-HSA-177135.3 Conjugation of benzoate with glycine 389396 116285 348158 10249 219970 92292 VLDL CLEARANCE%REACTOME DATABASE ID RELEASE 95%8964046 VLDL clearance 346 7436 51599 55911 338 341 DEFECTIVE CYP1B1 CAUSES GLAUCOMA%REACTOME DATABASE ID RELEASE 95%5579000 Defective CYP1B1 causes Glaucoma 1545 SULFUR AMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 95%1614635 Sulfur amino acid metabolism 339896 100131187 51380 191 1468 1036 6821 875 4357 84890 2806 1491 23743 58478 635 4143 84245 55256 2326 4552 2805 51074 7263 4548 25828 4507 23474 58472 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME%R-HSA-159763.5 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 2621 2147 632 2158 2155 8858 5624 5627 2159 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 95%168249 Innate Immune System 5611 721 2519 3080 4179 1361 1380 10877 10878 730 731 27202 732 930 733 975 712 735 713 81494 714 715 716 717 719 3078 3075 1370 3426 1369 722 966 725 727 728 729 1604 80331 5864 5970 6616 54472 7334 1378 1386 10451 7410 51311 10695 55860 1508 830 7409 8651 23601 22875 2548 3551 2665 5300 10890 4615 374395 10549 5599 2799 201294 4973 5775 2207 5879 1118 1116 2204 1476 80301 932 4208 5834 10875 5836 27180 3310 81619 2215 2212 945 2219 3684 29108 2352 116844 387263 10857 114790 2588 6947 5870 124583 7323 960 7322 961 388698 2357 963 388697 965 968 3689 6836 5869 22931 3579 3577 5440 976 978 5878 5441 6727 4680 83716 338339 55276 4317 127829 4318 6993 4332 10493 5434 5435 160364 3240 3482 5437 79930 56729 8804 23218 5553 5795 1075 140885 5787 5788 5547 6518 4353 1088 353189 25840 1084 56954 6402 1460 11322 5799 5315 23317 29099 55754 10120 8836 11333 5328 5329 23406 8972 64114 126014 3043 8621 4125 4126 89777 10694 57826 170482 23412 683 684 566 6317 11314 7525 9961 5588 4033 8876 25801 210 5236 64386 51071 10383 10326 101 56888 55313 7305 8635 10321 9725 10562 326624 60 441864 6590 84329 84443 51646 5273 54918 1823 5036 138050 29952 199675 5269 8778 53831 5284 26 154664 9522 9535 8566 401258 5049 7157 51316 6036 9545 11026 55 7133 6286 11031 25798 9208 25797 7130 6282 387921 2919 374403 10394 11240 290 2220 175 178 1401 8547 150372 10159 10584 7276 23114 3903 55832 25 23593 10043 10288 1727 9342 9588 100049587 3916 51806 222487 83858 81567 2950 22918 51816 1512 1992 57126 8288 7077 1522 9145 57020 258010 8655 1654 1774 84766 3848 58485 93100 84514 79169 2992 3608 2517 53916 53917 26578 1315 5912 84658 998 5806 23071 84418 2896 4831 51143 387 1147 1778 5519 84265 55703 71 11128 51728 58484 5515 27297 661 5516 5518 10623 171568 79980 1729 55718 10622 10621 5528 4791 3929 2244 2266 7414 51411 9402 2243 3937 917 3702 2534 4651 6850 3055 4620 3932 4641 2214 2147 5627 8454 6500 10577 51284 5336 161 3615 3614 121260 5894 5906 5908 5566 5567 5568 10235 10125 1785 3984 4627 7318 7226 10533 3093 10010 7335 9641 3665 8945 8673 114609 7448 10075 115727 4775 4860 272 2209 353 4772 5534 6271 1915 4210 10910 5530 5532 9051 26253 50856 10462 93978 79132 54476 8887 54941 3326 3107 3106 23352 51719 28956 9020 997 10892 84433 55004 64170 8649 64581 5971 3133 9246 8773 203068 5062 1536 1535 10458 7879 55845 4688 4689 1520 8936 80184 10787 10152 10333 9039 9040 8987 3071 51191 5058 23200 10163 23191 653361 79895 10006 22861 124599 284266 115004 54210 7462 100132285 2495 9436 9447 7294 2206 7184 2205 342510 2512 4025 78989 196051 5648 22914 2547 7454 3809 7520 170506 7456 3810 3813 2040 3822 3824 84513 10788 80143 64333 147179 23250 8826 196527 23526 10396 5063 4650 644150 5337 3728 8976 6778 5591 3685 8915 5604 84166 8694 6285 6288 92610 2171 6283 51295 51135 4214 7100 9684 4793 28512 57161 79671 3687 177 121457 81793 246330 28511 3656 257397 23118 1326 5609 466 80216 6416 5601 7867 5602 5606 51082 3442 3441 3440 3452 4153 3451 3449 9533 3448 3447 3446 948 3445 3444 3443 3456 9636 26007 5223 230 30835 2821 327 3101 5211 226 596 4311 598 1387 5777 2353 2002 5747 10555 3725 9798 5660 2760 5023 2717 1759 410 2268 4842 4843 3710 4846 5027 427 79888 6300 5603 338 26052 1398 5175 8772 28988 3708 3709 929 79792 6386 6709 3553 837 838 353376 841 3837 1828 11035 5641 1832 2934 8904 148022 14 5317 3146 23643 7099 3606 57162 1687 5598 51231 102 1849 1848 5663 1846 23385 1845 84061 1650 51125 10855 23646 5589 8767 57506 221 4067 695 9868 7006 8895 4048 5478 55593 4282 240 9097 1072 302 114548 1265 829 11274 5581 7128 89122 10768 4792 10392 8411 8560 4064 80231 23586 3663 6197 51552 6196 64145 9450 9252 6195 4205 24145 7706 11010 84282 6885 7187 7186 7189 56667 79155 8398 10970 10454 5880 64127 80142 4690 1540 8737 329 122618 57153 64135 6793 3163 330 7415 5338 94103 5781 4893 245972 245973 155066 8517 9114 51606 5594 5595 30849 9550 523 525 526 527 1509 528 529 8992 391 5289 26999 6654 90423 3265 127124 634 23545 51382 54509 533 10810 534 4644 5873 535 10312 50617 5295 5296 158747 9296 5290 5291 63916 5170 9846 54106 81622 7098 808 1794 1793 23197 7321 25852 5094 10133 23291 5724 2358 5265 7979 4361 351 197 12 9140 9474 1 3920 383 245936 245937 245938 245939 6278 5068 5266 4057 6279 6037 613210 10487 116842 613211 245930 728358 245932 245934 503841 671 641517 475 710 613209 1660 55600 400830 5473 51248 5657 10578 10450 130120 54209 729230 967 4069 1671 5004 1670 245940 338324 6280 7097 7096 1191 55894 1668 57119 100133267 5005 140683 140881 5768 51297 57115 920 6039 6556 128859 1669 245913 8993 5320 503618 503614 245911 122665 117285 80341 1511 1235 59307 114770 11213 114771 2683 1113 140850 823 1673 1672 1991 538 417 6406 3934 245927 245928 245929 81623 84659 3347 3346 820 149954 117159 5645 644414 92747 5646 504180 47 11001 9218 8514 3385 3384 1499 3417 30 5580 3428 9861 6233 197358 3654 9261 3312 7316 3162 10213 5608 5706 5707 5708 5709 3683 4773 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 834 5718 835 5719 1432 11047 5713 5714 5690 10628 5691 5692 5693 843 5694 7311 847 5695 7314 4790 3304 5687 5688 5600 5689 842 317 836 1675 3004 629 718 9844 8907 6093 6515 567 10576 22954 3661 340061 29110 147945 81844 23220 81030 11277 6737 51428 2990 3074 2444 411 2720 4718 3320 5335 143662 118430 4582 5199 4583 4584 4585 4586 200958 727897 2033 10071 94025 140453 4588 4589 283463 394263 1938 9761 1143 4771 10109 10552 10093 10092 10095 10094 10097 10096 51209 5476 51517 83737 7295 4257 1514 1513 1515 1471 3958 4758 MAPK1 (ERK2) ACTIVATION%REACTOME%R-HSA-112411.3 MAPK1 (ERK2) activation 3716 7297 5594 5605 3569 5781 3717 3570 CERAMIDE SIGNALLING%REACTOME%R-HSA-193681.4 Ceramide signalling 4803 4804 6610 VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME%R-HSA-5218920.4 VEGFR2 mediated vascular permeability 253260 3320 207 5063 57761 1499 5879 4846 3728 5170 117145 55615 64223 808 857 10451 7410 2475 1495 208 5058 10000 1500 1003 7409 79109 5062 FRUCTOSE CATABOLISM%REACTOME%R-HSA-70350.9 Fructose catabolism 3795 229 216 26007 132158 REGULATION OF CDH1 FUNCTION%REACTOME%R-HSA-9764561.1 Regulation of CDH1 Function 2060 1499 1785 999 9861 6233 79872 27085 7316 6714 10213 4193 5706 5707 5708 7414 5709 5700 5701 5702 1520 5704 5705 5682 5683 5684 5685 5686 10399 5717 1514 5718 3728 5719 11047 5713 5714 5690 5691 5692 5693 54971 5694 7311 7979 5695 7314 5687 5688 5689 1495 1500 1508 MYOGENESIS%REACTOME DATABASE ID RELEASE 95%525793 Myogenesis 6938 4756 4209 1000 1499 50937 4208 1432 998 6300 6929 4205 5600 1495 9043 1013 1496 4207 6925 4617 4618 663 25 4917 1002 4654 4656 5608 RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME DATABASE ID RELEASE 95%8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 861 865 84333 8289 55193 10138 1460 8535 6595 6597 1459 6045 2033 6599 57492 6598 1457 648 6015 23466 1912 1911 23429 80012 57332 84733 26053 6601 51412 6603 6602 6605 196528 6604 28996 86 REGULATION BY C-FLIP%REACTOME DATABASE ID RELEASE 95%3371378 Regulation by c-FLIP 8772 8797 8737 355 356 8717 8795 7186 8743 841 THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME DATABASE ID RELEASE 95%8852276 The role of GTSE1 in G2 M progression after G2 checkpoint 5706 5707 3320 5708 5709 5700 3326 5701 891 1026 5702 983 5704 5705 5682 5347 5683 5684 5685 5686 63943 5717 5718 5719 11047 51512 5713 7157 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 9861 22919 6233 5687 5688 5689 9133 7316 10213 RUNX2 REGULATES CHONDROCYTE MATURATION%REACTOME DATABASE ID RELEASE 95%8941284 RUNX2 regulates chondrocyte maturation 865 9759 3549 2736 BUDDING AND MATURATION OF HIV VIRION%REACTOME DATABASE ID RELEASE 95%162588 Budding and maturation of HIV virion 91782 5478 92421 55048 89853 51534 9525 137492 27183 51271 51160 155382 93343 7251 79720 51510 27243 128866 10015 29082 25978 7311 7314 6233 7316 79643 51652 23327 MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME%R-HSA-5419276.6 Mitochondrial translation termination 6150 55168 64949 28973 65080 51642 54998 5018 10573 11222 128308 51649 9553 64960 92259 64963 63875 64965 64968 55052 55173 64969 51373 26284 51650 51253 60488 51258 219927 29074 56945 28998 64975 79590 64976 64979 64978 23107 28957 64928 7818 51263 29088 51021 57129 54534 51023 51264 51069 84545 78988 122704 65993 64981 10240 64983 3396 63931 26589 54460 6182 6183 118487 51073 116540 740 124995 54148 116541 55037 29093 9801 51116 10884 54948 51318 9617 4508 4509 84340 4512 4513 4514 4519 4539 54516 4540 4541 4535 4536 4537 4538 92399 64432 65003 64951 65005 65008 28977 90480 51081 EVASION BY RSV OF HOST INTERFERON RESPONSES%REACTOME%R-HSA-9833109.1 Evasion by RSV of host interferon responses 3716 7706 3454 7297 64135 1387 3442 3441 3661 2033 3440 5610 8065 7311 3452 23586 3451 7314 3449 3448 3447 6233 3446 3445 57506 9978 3444 3443 3456 7316 6921 6923 6773 PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME%R-HSA-5576886.3 Phase 4 - resting membrane potential 3776 60598 89822 3777 51305 56660 8645 9424 3775 10089 83795 3768 56659 54207 50801 3770 338567 3761 3759 SYNTHESIS OF PE%REACTOME%R-HSA-1483213.5 Synthesis of PE 1120 85465 64900 162466 55224 23761 5833 1119 23175 64850 55500 9663 10390 CIPROFLOXACIN ADME%REACTOME DATABASE ID RELEASE 95%9793528 Ciprofloxacin ADME 6580 213 6579 9429 9376 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250342.6 PI3K events in ERBB4 signaling 2069 9542 5295 10718 1839 145957 5290 3084 685 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME DATABASE ID RELEASE 95%164378 PKA activation in glucagon signalling 113 114 115 107 108 109 196883 5566 5567 5568 2778 5573 5575 5576 5577 111 112 DEVELOPMENTAL CELL LINEAGES OF THE INTEGUMENTARY SYSTEM%REACTOME DATABASE ID RELEASE 95%9734779 Developmental Cell Lineages of the Integumentary System 2255 1950 374 7039 5617 MASITINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669924.2 Masitinib-resistant KIT mutants 3815 SIGNALING BY FGFR3%REACTOME DATABASE ID RELEASE 95%5654741 Signaling by FGFR3 673 8074 5335 867 2249 2247 2246 2591 10817 8823 5295 10253 8569 5781 4893 5290 2549 5515 7311 5516 7314 5518 5594 5595 6233 10818 7316 8817 26281 6654 2254 3265 INTERLEUKIN-15 SIGNALING%REACTOME DATABASE ID RELEASE 95%8983432 Interleukin-15 signaling 3561 3716 9846 6776 3560 2885 6774 6655 6464 3601 3718 6654 3600 6777 PHASE 0 - RAPID DEPOLARISATION%REACTOME%R-HSA-5576892.4 Phase 0 - rapid depolarisation 783 27092 59285 59284 775 6324 2259 6323 2258 2257 2256 6331 6330 59283 782 29098 6332 808 6335 6334 6326 6328 6327 6329 815 6336 11280 816 55800 817 818 9254 SIGNALING BY HEDGEHOG%REACTOME DATABASE ID RELEASE 95%5358351 Signaling by Hedgehog 113 374654 114 8100 115 80199 51098 55811 107 79809 108 26160 109 196883 6608 11127 57728 23432 5566 8452 5567 27152 57539 5568 10956 54903 5727 6868 408 409 8405 2778 8650 51684 8945 2735 64399 22873 25989 57758 339745 85455 3549 50937 91653 132884 7415 2121 23288 2622 5573 84455 5575 2619 5576 5577 79577 55733 6469 50846 84447 2737 2736 2262 57154 9861 6233 9978 2932 7316 1452 10213 5706 5707 5708 5709 83737 5700 5701 5702 5704 5705 64750 5682 5683 5684 5685 5686 5717 5718 5719 27248 11047 5713 156 5714 51009 5690 8481 5691 5692 6400 5693 5694 7311 7979 5695 7314 8454 5687 5688 5689 6500 7289 5034 9742 23322 147111 55081 111 55764 112 79659 FGFR1 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839124.4 FGFR1 mutant receptor activation 2251 8074 6776 2249 399687 2247 2246 11116 8805 5295 6772 5290 1523 9846 11052 613 9208 11160 7750 26127 6774 26281 2260 9530 2254 6777 MPS I - HURLER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206302.5 MPS I - Hurler syndrome (HS-GAG degradation) 3425 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME DATABASE ID RELEASE 95%2565942 Regulation of PLK1 Activity at G2 M Transition 10383 10382 1781 1778 7846 5566 9793 7277 5518 6233 9738 6790 84962 9662 7316 7840 5500 11064 22994 22995 7283 10733 80321 203068 8945 55722 1454 1453 3320 55125 9814 11190 115106 79441 95681 1069 891 54801 983 10142 9702 10133 10540 8655 5347 5108 23291 11116 4218 4751 55142 22897 4659 54930 5116 79959 80184 93323 79866 5577 23354 22981 8481 80254 121441 55755 23332 7311 7532 10806 7314 10121 7531 55559 8636 8454 22919 11258 5048 84131 4957 55835 9133 6500 54820 PAUSING AND RECOVERY OF TAT-MEDIATED HIV ELONGATION%REACTOME DATABASE ID RELEASE 95%167238 Pausing and recovery of Tat-mediated HIV elongation 6829 2963 2962 5434 5435 5436 5437 5438 5439 8178 25920 5430 5431 51224 5432 6924 5433 7936 6827 6749 9150 6917 1025 51497 7469 11198 904 6921 6923 5440 5441 TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME DATABASE ID RELEASE 95%5633008 TP53 Regulates Transcription of Cell Death Genes 8797 5366 1121 8738 8626 637 63970 9540 55240 23368 581 55367 834 27113 472 835 10650 839 332 27166 1387 7157 51499 58484 665 843 355 604 94241 7159 84883 10397 5875 5876 147923 124446 79370 64065 7161 317 8794 8795 3486 8793 SCAVENGING OF HEME FROM PLASMA%REACTOME%R-HSA-2168880.3 Scavenging of heme from plasma 4035 8542 3512 213 259 335 3263 3040 9332 3250 3240 3043 DEFECTIVE B3GALTL CAUSES PPS%REACTOME DATABASE ID RELEASE 95%5083635 Defective B3GALTL causes PpS 92949 170691 7057 145173 57188 10417 10418 170689 171019 54437 9510 9037 5199 7058 157869 9507 140766 80070 9508 9509 339366 221981 79875 81794 55901 81792 9719 56999 11173 11096 11095 11174 80731 170690 54507 11093 170692 HYDROLYSIS OF LPC%REACTOME%R-HSA-1483115.5 Hydrolysis of LPC 79887 56261 123745 100137049 5321 8605 23659 255189 283748 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%R-HSA-72737.4 Cap-dependent Translation Initiation 6152 6155 6154 6157 9349 6156 6159 6158 23521 51121 11224 6164 200916 6166 6122 6165 6124 6168 6123 6167 6169 6125 116832 8893 25873 8891 6160 8892 6161 8890 140801 4736 1967 6130 6133 9045 6230 6232 6132 6210 6176 6231 6135 6234 6134 6235 6137 6191 6136 2197 6193 6171 6192 6170 6194 6173 6128 51065 6129 140032 6142 6205 6227 6141 6144 6204 6143 6207 6229 6146 6147 6206 1974 6228 6181 1973 6139 6138 6209 6208 6188 6187 6223 6201 6189 6222 6203 6224 6202 6218 6217 3921 8894 8662 1965 8663 8661 8666 1975 8667 8664 1968 8665 27335 3646 51386 7458 1978 8668 1977 8669 10480 1964 6233 6175 1981 9669 1983 7311 26986 DEFECTIVE ACTH CAUSES OBESITY AND POMCD%REACTOME DATABASE ID RELEASE 95%5579031 Defective ACTH causes obesity and POMCD 5443 4158 DEPYRIMIDINATION%REACTOME%R-HSA-73928.3 Depyrimidination 474382 54145 8970 8331 8337 128312 8334 8335 4968 8370 55766 8341 8342 8930 8347 8290 8348 55247 94239 23583 8345 26277 3013 252969 25913 8340 7013 65057 7014 8338 79661 255626 54386 6996 4913 3018 3017 85236 3014 8349 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME DATABASE ID RELEASE 95%264870 Caspase-mediated cleavage of cytoskeletal proteins 118 28988 2934 840 7431 6709 2620 836 5339 839 841 4137 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME DATABASE ID RELEASE 95%3371453 Regulation of HSF1-mediated heat shock response 3305 3309 3310 10808 9261 348995 9883 6396 129401 3297 3312 9688 2932 57122 23225 4927 23165 9530 8021 55746 55706 23636 9631 7175 3313 9972 11097 23279 8086 23511 53371 8480 27000 79023 259217 79902 116835 10762 7266 5903 51182 573 6767 51501 57805 9531 9532 22824 6782 91582 9529 472 10049 3308 5594 7531 5595 3304 23411 545 6117 6119 3337 6118 3306 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME DATABASE ID RELEASE 95%983168 Antigen processing: Ubiquitination & Proteasome degradation 154881 7320 7325 6477 131405 221687 79654 51088 9616 90678 7318 7317 56658 7319 10533 22888 3093 9870 7335 150726 10425 7332 64718 118424 23295 55336 7327 7326 197131 9867 7328 8945 10422 54926 65264 9520 10193 10075 93611 127247 401036 79791 55585 57520 89910 51665 7337 51666 26091 55905 63893 7334 142686 57531 7336 142685 55236 51676 142689 223082 91694 10293 9666 51320 80204 10616 57542 51444 11146 135892 55008 6047 6049 23376 23014 57674 143279 25793 84231 11275 9320 55819 64410 90025 222235 84937 140691 51465 54850 140456 140458 90933 140459 80028 23194 8651 90135 25897 9690 146330 140460 140461 140462 255488 114088 54620 23352 868 8916 115290 7704 55958 8139 390594 127544 55284 84961 27246 997 8924 122769 8925 64320 9354 81559 55175 84708 7174 6478 27252 8453 51130 9861 7323 642 6233 7322 51132 26046 9903 9978 9246 4591 25847 7316 6921 6923 158506 92369 54778 55182 126433 10213 7428 26259 64219 23304 7064 201456 144699 5706 5707 899 5708 84861 63891 92912 5709 10477 26268 55070 5700 90293 5701 84727 92591 5702 26263 5704 26267 5705 64750 5682 53339 5683 10489 5684 285231 5685 89890 5686 4012 9820 5717 26235 5718 26118 5719 79176 26232 55521 5071 11047 84085 5713 26272 4008 5714 5690 51725 89122 5691 9039 5692 26249 5693 25831 5694 8065 84078 7311 5695 55658 26234 140739 7314 51619 9040 148581 79876 6468 5687 79754 5688 84541 9730 5689 154214 51191 26190 151636 80176 26270 9604 136371 10324 23327 55294 8452 10517 5930 84261 22954 57630 26224 6737 54461 23608 4734 80196 9817 200845 51343 6502 991 10273 84676 11059 29116 57154 114907 51529 7321 8881 64682 11065 8697 7324 10393 29945 27338 83737 29882 246184 996 51434 51433 23291 7979 9021 8454 142678 6500 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME%R-HSA-416550.4 Sema4D mediated inhibition of cell attachment and migration 5879 4233 10507 387 2909 6237 5364 27289 PPARA ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%1989781 PPARA activates gene expression 11010 335 336 183 1581 10498 5244 84498 405 196 406 10025 27242 9968 9969 892 10001 27063 5465 29079 1579 57491 5468 5469 6822 1543 4899 9862 29841 2033 3992 376497 2274 9572 26230 3158 2180 6256 6604 90390 2168 6257 6095 57761 6907 51003 8648 79718 84246 7376 9612 10062 10891 8841 9611 19 123 23054 9443 9441 2874 9442 54797 55090 9440 211 8202 80306 133522 51586 948 9439 9971 23097 6837 219541 23389 1376 55588 9412 4199 400569 9915 9967 81857 7296 9477 112950 4862 1374 23179 80205 8800 85441 10499 2101 96764 9575 1387 2222 6667 34 3157 6721 1024 4520 4800 4801 4802 51129 54600 50486 9282 116519 TNF SIGNALING%REACTOME DATABASE ID RELEASE 95%75893 TNF signaling 27005 3551 6610 257397 6885 23118 6868 7186 55512 29110 56957 220213 7132 55072 9825 7323 6233 7322 9261 8772 9641 10454 7332 7316 9530 7321 1540 8737 329 9099 841 10133 330 7185 10399 7375 84888 90268 25999 8439 56928 7124 7128 8517 10273 10616 7311 8717 7314 8408 142678 331 1147 81858 8887 MPS II - HUNTER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953078.1 MPS II - Hunter syndrome (CS DS degradation) 3423 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%R-HSA-1296346.3 Tandem pore domain potassium channels 83795 3776 89822 3777 56659 51305 54207 50801 338567 9424 3775 10089 TCR SIGNALING%REACTOME DATABASE ID RELEASE 95%202403 TCR signaling 6885 7189 7454 7335 920 7408 50852 8945 4690 5335 5970 5063 7334 26191 7535 8517 8915 1147 3551 23118 5295 5296 997 10892 5290 84433 5291 5170 51466 9861 6233 7322 55824 8767 3635 7316 10213 7321 5062 5706 5707 5708 5709 9402 3123 3122 3120 5700 5701 55740 3119 5702 3937 3118 1445 3117 5728 3115 5795 5704 3113 5705 915 5682 23291 5683 27040 916 5788 5684 917 5685 5686 9398 2533 3127 5717 3126 5718 3125 5719 3702 11047 3932 5713 5714 5690 5691 5692 5693 4792 5694 7311 7979 5695 7314 4790 8454 5687 5688 5689 5058 6500 5588 5336 PROPIONYL-COA CATABOLISM%REACTOME%R-HSA-71032.4 Propionyl-CoA catabolism 5096 4594 166785 84693 5095 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME DATABASE ID RELEASE 95%174084 Autodegradation of Cdh1 by Cdh1:APC C 9861 6233 7316 10213 51529 7321 5706 8881 64682 5707 25906 5708 11065 8697 5709 7324 10393 29945 27338 119504 5700 5701 29882 5702 246184 996 5704 51343 51434 5705 51433 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 5687 5688 5689 TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME%R-HSA-5626978.3 TNFR1-mediated ceramide production 55512 10399 7132 6610 8439 7124 DISEASES OF CELLULAR RESPONSE TO STRESS%REACTOME DATABASE ID RELEASE 95%9675132 Diseases of cellular response to stress 1029 1021 1019 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%R-HSA-114604.7 GPVI-mediated activation cascade 51206 3937 2207 5879 27040 5295 5296 5590 2534 6850 5781 3932 5290 5291 5170 8503 998 5777 10451 7410 4067 5880 146850 5294 23533 387 7409 391 388 5336 10630 51266 80739 TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME DATABASE ID RELEASE 95%110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 7706 9100 7353 5980 10459 10714 5424 51455 5425 5981 57804 5982 56655 5983 7415 5429 55666 5426 5427 51426 83932 9768 124739 54107 7318 7311 5111 7314 11201 6233 9246 6117 7316 5984 5985 9636 6119 6118 DEFECTIVE EXT1 CAUSES EXOSTOSES 1, TRPS2 AND CHDS%REACTOME%R-HSA-3656253.6 Defective EXT1 causes exostoses 1, TRPS2 and CHDS 6382 2239 2719 2817 375790 2131 3339 6383 221914 9672 10082 6385 2262 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%R-HSA-2173796.6 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription 4904 5045 3065 4087 4088 7027 4089 7050 1875 1874 4092 5054 7029 905 1025 25937 4221 904 6667 1030 892 4609 2033 1024 8812 5933 7311 7314 5594 60436 5595 6233 1278 3726 7316 54778 DEFECTIVE MAT1A CAUSES MATD%REACTOME DATABASE ID RELEASE 95%5579024 Defective MAT1A causes MATD 4143 MAPK3 (ERK1) ACTIVATION%REACTOME%R-HSA-110056.5 MAPK3 (ERK1) activation 3716 5604 7297 3569 5595 5781 983 3717 3570 DEFECTIVE NEU1 CAUSES SIALIDOSIS%REACTOME DATABASE ID RELEASE 95%4341670 Defective NEU1 causes sialidosis 4758 2720 5476 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190371 FGFR3b ligand binding and activation 8817 26281 2246 2254 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9632697.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 1029 1019 MTF1 ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%5660489 MTF1 activates gene expression 1465 6620 4520 BILE ACID AND BILE SALT METABOLISM%REACTOME%R-HSA-194068.3 Bile acid and bile salt metabolism 123264 10858 8714 1646 1645 6718 213 9023 1582 3295 1581 2172 6555 6554 28234 8648 10499 80765 8644 80270 26031 9885 570 114876 51302 1593 8309 114880 8647 114881 114883 1109 10998 11001 9971 9420 10005 6256 10599 6579 5007 23600 200931 BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME%R-HSA-9018677.3 Biosynthesis of DHA-derived SPMs 1544 1571 4048 1543 1565 1559 5743 240 3248 246 1576 2053 239 2948 4056 1558 SIGNALING BY AMER1 MUTANTS%REACTOME%R-HSA-4839748.5 Signaling by AMER1 mutants 5515 5516 5518 5525 5526 8312 2932 5527 324 5528 1452 5529 139285 5519 AUTOINTEGRATION RESULTS IN VIRAL DNA CIRCLES%REACTOME%R-HSA-177539.4 Autointegration results in viral DNA circles 3159 11168 8815 OPSINS%REACTOME%R-HSA-419771.3 Opsins 94233 6010 221391 611 5995 10692 23596 5956 2652 DEFECTIVE B4GALT7 CAUSES EDS, PROGEROID TYPE%REACTOME DATABASE ID RELEASE 95%3560783 Defective B4GALT7 causes EDS, progeroid type 6382 2239 2719 2817 375790 1462 3339 63827 1634 11285 6383 221914 633 9672 1464 10082 6385 1463 10675 2262 MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 95%430039 mRNA decay by 5' to 3' exoribonuclease 167227 219988 23644 23658 27258 54464 1656 196513 27257 80153 51690 57819 25804 55802 11157 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME DATABASE ID RELEASE 95%210745 Regulation of gene expression in beta cells 3375 3630 3170 207 6514 6927 4821 4760 3174 389692 208 222546 10000 3171 3651 2645 2308 4825 5080 U12 DEPENDENT SPLICING%REACTOME%R-HSA-72165.3 U12 Dependent Splicing 4904 10594 11325 85437 23020 10992 9410 10081 6432 6431 55599 6427 6426 9416 8233 5440 5441 2963 2962 5434 5435 5436 5437 5438 5439 22916 79622 5430 83443 4686 5431 5432 5433 55954 9343 6632 154007 6628 10262 51639 23450 23451 6634 6633 6636 6635 11066 6637 10907 24148 CAM-PDE 1 ACTIVATION%REACTOME DATABASE ID RELEASE 95%111957 Cam-PDE 1 activation 5136 5137 808 5153 XAV939 STABILIZES AXIN%REACTOME DATABASE ID RELEASE 95%5545619 XAV939 stabilizes AXIN 8658 80351 FORMATION OF DEFINITIVE ENDODERM%REACTOME DATABASE ID RELEASE 95%9823730 Formation of definitive endoderm 8320 6862 999 4087 4088 3170 4089 1499 145258 2626 83881 6934 7852 64321 2627 NOD1 2 SIGNALING PATHWAY%REACTOME%R-HSA-168638.5 NOD1 2 Signaling Pathway 1540 329 3551 83737 837 3656 841 257397 6885 23118 330 7334 834 835 1432 7189 64170 14 7128 8517 10392 6300 5603 8767 3654 5600 7335 10454 842 64127 1147 5608 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 95%500792 GPCR ligand binding 553 554 50840 5739 6753 116 117 27202 135 719 7349 2847 2778 4852 727 728 1604 3549 1392 136 5729 11251 5731 5732 5733 5734 5737 6915 7252 7473 7479 2357 7478 3579 3577 976 154 2793 2792 2791 2790 2788 2787 2786 2785 2784 2783 51764 94235 2864 2695 55970 183 54331 59345 2782 10681 2919 2692 2691 9340 2740 7433 6344 7432 6343 7434 2696 5196 3972 84658 6351 6352 58191 6354 6357 6356 6348 6347 6349 2826 10850 6361 9034 6364 6363 6366 6367 1230 6360 2833 643 10663 6373 6372 6374 6376 6370 1238 2921 57007 2920 1237 1236 1233 3576 1232 56477 4283 6387 6346 10803 51554 10563 3627 7852 1234 5020 4295 7200 5021 7201 56413 5031 5032 1909 1908 94233 2798 2797 2796 1907 5028 1906 84432 5029 6375 1241 2693 1910 84109 10874 29933 222545 10887 5724 10886 257313 387129 2911 2358 846 2915 4985 7484 8111 8477 2922 2147 2925 54361 6846 10161 185 623 351 5030 624 53829 2488 140 64805 134 56923 9934 2151 2150 57105 2149 2829 2828 885 886 887 2837 347148 9002 338557 3814 10911 2840 2846 594857 64106 301 129521 128674 2867 3827 2865 2863 2862 60675 4922 4923 10800 8620 680 27334 84634 3060 5367 23620 3062 3061 10316 4828 4829 2642 2641 5473 84539 729230 163404 8698 57121 9170 9890 23566 64748 9294 54886 79948 1903 1902 1901 53637 1235 1129 1128 1133 1132 1131 7483 89780 7481 7976 7855 8322 9287 3363 8323 3362 150 3361 151 2535 3360 152 59340 153 155 3358 165140 3357 3356 3355 1816 83551 1815 1814 1813 1812 134864 319100 134860 9038 3354 3352 3274 3351 3350 146 147 148 3269 11255 4935 5956 4986 4988 5726 6750 133 796 797 799 718 259289 79924 3375 10266 259287 10268 259286 10267 259285 10203 6608 259293 5727 259292 259290 259296 259295 5443 2652 1081 6010 54429 4158 80835 80834 7480 611 221391 5995 10692 23596 3640 51083 90226 1240 56670 338398 170589 4987 3792 6469 27198 50846 27199 5741 2550 80326 6288 2587 4886 4887 4889 122042 1394 1393 2359 1269 1268 5744 5745 5746 2492 4543 4544 259294 2015 353164 6751 5540 6752 5539 116512 338442 6755 10022 6754 8811 339403 51384 151306 8843 5697 8321 256933 8325 7504 7471 11211 51289 4142 8862 51052 4157 114131 9718 4161 8643 4160 5368 4159 30817 117579 113091 5173 7472 7475 7477 9568 8326 7476 6019 7482 1524 7253 2918 2917 2916 2913 2912 8484 186 187 50835 2834 2832 2831 122876 1880 283869 2841 57486 2914 2853 551 2852 2859 50865 1889 2861 9283 3973 9290 59350 1325 2532 6870 6863 6865 6866 6869 83756 50831 50833 50832 50834 5179 50837 7474 50836 8324 50839 50838 5660 552 DEFECTIVE SLC9A6 CAUSES X-LINKED, SYNDROMIC MENTAL RETARDATION,, CHRISTIANSON TYPE (MRXSCH)%REACTOME%R-HSA-5619092.4 Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH) 10479 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 95%375165 NCAM signaling for neurite out-growth 6708 6710 783 5623 6712 375790 64096 5786 775 1297 779 8912 8913 8911 1284 1282 1286 1285 256076 782 784 785 131873 1293 1292 1291 57731 6711 1463 1287 51332 6709 6900 4902 9048 5621 2534 4893 8128 5594 5595 9252 4684 7903 5747 2668 2675 2674 6654 776 1299 1298 3265 SARS-COV-2 ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME%R-HSA-9705671.5 SARS-CoV-2 activates modulates innate and adaptive immune responses 7706 3454 84282 6885 6772 3105 567 7187 7189 3661 340061 29110 5648 7097 7096 9871 348995 80143 9632 9883 7335 6396 9641 129401 3665 9688 10454 10427 57122 23225 4927 64127 23165 55746 55706 23636 9631 7175 3320 9972 11097 23279 8086 23511 53371 8480 79023 79902 10762 64135 5903 22863 7334 5781 8517 30849 51311 5289 1147 3551 3326 3107 3106 3656 257397 23118 91662 84818 3442 9908 3441 10146 3440 3134 3133 23765 6441 3452 4153 3451 3449 7555 3448 3447 8767 23367 3446 3445 57506 3654 3444 3443 3456 9868 9636 26007 3605 112744 8678 8021 3135 3716 7297 10802 10484 114548 1387 3838 5777 89122 10392 23586 51128 51284 6773 INITIATION OF NUCLEAR ENVELOPE (NE) REFORMATION%REACTOME DATABASE ID RELEASE 95%2995383 Initiation of Nuclear Envelope (NE) Reformation 2010 22933 5515 4001 5518 891 3930 983 8815 3837 9133 23141 7443 5520 23592 221496 SARS-COV-2 MODULATES AUTOPHAGY%REACTOME DATABASE ID RELEASE 95%9754560 SARS-CoV-2 modulates autophagy 55823 7284 65082 11311 27072 57617 64601 23339 81631 26276 7405 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296041.4 Activation of G protein gated Potassium channels 3772 55970 3762 3763 3765 3766 3768 54331 59345 2793 2792 3773 2791 2790 2788 2782 2787 2786 2785 2784 2783 51764 10681 9568 94235 3760 3761 2550 3759 TRANSCRIPTIONAL AND POST-TRANSLATIONAL REGULATION OF MITF-M EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 95%9856649 Transcriptional and post-translational regulation of MITF-M expression and activity 3065 3094 1435 5454 1499 51176 8600 2058 5443 3397 7341 999 6591 7329 4157 4161 4160 4159 2932 7514 7534 1908 6662 51520 1615 4140 3376 1906 7965 9521 7529 6657 9255 1910 89780 5859 4141 22797 5917 7545 3735 27022 257 6926 7942 1387 4286 7030 2033 7532 5594 7531 5595 6195 7533 3815 6663 23411 10000 5077 NFE2L2 REGULATING TCA CYCLE GENES%REACTOME%R-HSA-9818025.2 NFE2L2 regulating TCA cycle genes 3417 4780 4199 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY DVL-INTERACTING PROTEINS%REACTOME%R-HSA-5368598.3 Negative regulation of TCF-dependent signaling by DVL-interacting proteins 440193 1857 1856 1855 DEFECTIVE OGG1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 95%9656256 Defective OGG1 Substrate Processing 4968 CELLULAR RESPONSES TO STIMULI%REACTOME%R-HSA-8953897.9 Cellular responses to stimuli 5611 1327 5928 1329 1340 1337 5931 1339 1351 1350 1349 1347 1346 1345 5584 5970 125965 3329 3569 1386 4493 4494 4495 4496 10294 55860 4499 51164 4489 4501 3337 4502 830 6604 4504 2288 55466 84560 10671 4490 1639 4306 613227 51266 93661 3306 3305 84516 3301 10728 10370 3551 8878 5599 79813 59284 4208 3310 4697 55615 8453 7323 7322 2034 126374 84962 9978 3091 2289 112399 112398 8994 6921 6923 64344 54583 7428 6648 2793 2792 2791 1460 2790 1459 2788 1457 2787 2786 2785 2784 7531 2783 51764 3043 23410 23411 94235 6696 55970 81502 54331 2767 59345 7157 2782 2776 9451 10681 348995 50507 9883 6396 129401 9688 9780 57122 1003 23225 25 4927 3159 23165 55746 55706 9588 23636 253260 9631 7175 9972 11097 23279 2950 8086 23511 53371 8480 79023 79902 10762 5903 6232 8655 2908 493869 140809 79400 30001 10061 257202 2938 1728 2940 10935 27244 644 645 84181 6649 9572 318 2880 2878 10587 2882 9973 51143 1147 1781 1780 6347 1778 6095 9377 1783 10919 3688 5519 3576 140735 5515 83667 5518 9167 8131 201163 55846 23334 5526 440275 144577 23677 84219 10641 7422 2324 81929 55364 3791 652968 96459 2539 729438 79726 10985 154743 9681 57600 54468 7414 11133 7094 2534 4520 8454 51360 890 8900 6500 5034 783 213 335 5566 5567 5568 8720 84699 768 3397 22872 59341 343 9641 9530 8945 811 6230 6210 6231 6234 6235 6191 2197 6193 6192 6194 5573 51065 5575 140032 5576 6205 5577 6227 6204 6207 6229 6206 6228 1915 6209 6208 6188 6187 6223 6201 6189 6222 6203 6224 6202 6218 6217 3921 4851 5753 3326 5563 389541 28956 57521 55004 8649 10670 6009 10525 10808 3040 64121 64223 153129 84335 2475 58528 10542 10325 1536 1535 4688 4689 10540 9820 10424 10121 11258 653361 133 10266 10203 4001 3024 29855 25842 8091 7290 23523 57634 3009 3008 3007 3006 3005 7184 6152 6155 6154 6157 9349 6156 6159 6158 23521 51121 11224 6164 200916 6166 6122 6165 6124 6168 6123 6167 6169 6125 116832 25873 6160 6161 140801 27000 4736 259217 116835 6130 7266 51182 6133 9045 573 6767 6132 6176 51501 6135 57805 6134 9531 6137 9532 22824 6136 6782 6171 91582 6170 9529 6173 10049 6128 3308 6129 6142 6141 6144 6143 6146 6147 6181 1465 6139 6138 6620 8290 26277 25913 3690 7013 65057 3685 7014 54386 3678 2168 3339 5609 6416 5601 7867 5602 5606 8535 23054 6045 648 6015 1912 1911 23512 80012 57332 84733 2932 3456 139285 51726 2730 2729 10499 374 596 4780 5154 598 1387 6667 2114 7975 2113 113235 10488 1032 9812 1031 90993 148327 23043 50488 9448 26353 153222 27429 81501 1388 2353 4217 2077 2081 9709 55662 64764 10000 22926 2309 9361 5747 1410 3725 30827 111 112 113 114 115 107 108 109 196883 4846 5027 2931 338 5175 118 100137049 10072 2778 3552 4899 26043 64839 571 55666 3068 55062 10954 58477 6745 10113 10897 4000 23643 9797 4189 116138 9570 7099 6818 23657 7709 56005 10106 55033 1663 1200 2134 6734 64061 115209 11015 55738 5598 4097 5226 4363 8714 2137 2135 367 4194 6175 4193 3313 7353 6647 6888 302 114548 829 4792 5293 79594 6197 6196 6195 2056 24145 9429 781 782 784 2697 832 9817 3336 25828 10963 2099 2876 5586 3163 7415 245972 245973 155066 8517 9114 51606 5594 5595 9550 523 525 526 527 208 528 529 8992 90423 127124 51382 2887 57761 533 534 10312 5296 5770 6464 9296 5290 5291 5170 808 3297 3281 815 816 4199 817 818 51529 7321 8881 64682 25906 11065 8697 7324 10393 29945 27338 119504 29882 5029 246184 996 51434 51433 472 5520 672 10111 7979 4361 4683 10524 545 6117 6119 79728 6118 3309 475 1670 7086 84290 824 826 538 11331 30968 10730 4323 25942 1029 1017 1026 1499 8894 79094 1054 1051 23645 3417 440 10891 1965 27102 8912 467 468 22809 10413 1968 1649 4609 4343 192669 23112 27327 26523 27230 192670 57690 5580 9861 6233 11340 8570 9261 23404 54512 3312 7316 7514 3162 10213 5393 23016 8021 5608 5073 5706 5707 5708 51010 4512 5709 4513 167227 4514 51013 207 5700 5701 5702 118460 5704 5705 5682 5683 5684 5685 27287 5686 22894 5717 5718 5719 1432 56915 11047 1030 5713 5714 5690 10628 5691 5692 5693 5694 7311 847 5695 7314 4790 84701 3304 5687 5688 5600 5689 79109 54205 3484 2146 10013 25994 8452 10498 405 406 6772 341947 6737 81631 5465 8726 37 5469 3320 1950 5241 7027 1021 1019 1871 898 1870 51343 6502 9134 1027 7029 55620 1869 5925 8970 8331 8337 128312 8334 8335 2033 8370 55766 8968 23135 8341 8342 8347 8348 94239 8345 3013 8340 8338 255626 6256 6774 3021 653604 3018 3017 85236 3014 8550 8349 474382 54145 5052 6907 7001 8648 79718 84447 9695 9612 8204 8841 9611 23466 7296 4209 2673 4862 7295 80205 23373 85441 10743 96764 9575 64784 10130 200186 3490 7466 4800 4801 4802 2877 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME DATABASE ID RELEASE 95%912526 Interleukin receptor SHC signaling 3561 3716 5295 3562 5296 3559 3558 6464 3636 5290 5291 8503 9846 5777 5293 1437 3563 3560 3635 1439 1438 3568 3718 6654 3567 3717 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 95%937042 IRAK2 mediated activation of TAK1 complex 6885 23118 10454 7316 7311 7314 6233 7189 3656 257397 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME DATABASE ID RELEASE 95%110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine 474382 54145 8970 8331 8337 128312 8334 8335 4968 8370 55766 8341 8342 8930 8347 8290 8348 55247 94239 23583 8345 26277 3013 252969 25913 8340 7013 65057 7014 8338 79661 255626 54386 6996 4913 3018 3017 85236 3014 8349 HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME%R-HSA-3296197.3 Hydroxycarboxylic acid-binding receptors 338442 27198 8843 DRUG RESISTANCE IN ERBB2 KD MUTANTS%REACTOME DATABASE ID RELEASE 95%9665230 Drug resistance in ERBB2 KD mutants 11140 3320 2064 55914 PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME DATABASE ID RELEASE 95%392851 Prostacyclin signalling through prostacyclin receptor 2782 2788 2787 2786 55970 2785 2784 2783 51764 10681 5739 54331 2778 59345 94235 2793 2792 2791 2790 DEFECTIVE MMADHC CAUSES MMAHCD%REACTOME%R-HSA-3359473.4 Defective MMADHC causes MMAHCD 27249 25974 DENGUE VIRUS MODULATES APOPTOSIS%REACTOME%R-HSA-9920951.1 Dengue virus modulates apoptosis 253260 55615 8737 4792 4793 64223 30849 2475 1616 57551 22863 54463 79109 5289 8678 57521 B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-5250924.4 B-WICH complex positively regulates rRNA expression 474382 54145 60 6908 9188 51082 10514 9533 8850 8467 2932 5440 5441 25885 5434 5435 64425 5437 79101 10849 221830 8970 8331 2648 8337 128312 8334 8335 9014 9015 2033 9013 8370 55766 8968 84172 2074 7913 8341 8342 8347 8348 94239 8345 3013 9031 23451 8340 8338 255626 3021 653604 3018 3017 85236 3014 30834 8349 DEFECTIVE CYP24A1 CAUSES HCAI%REACTOME%R-HSA-5579010.4 Defective CYP24A1 causes HCAI 1591 LOSS OF MECP2 BINDING ABILITY TO 5MC-DNA%REACTOME DATABASE ID RELEASE 95%9022538 Loss of MECP2 binding ability to 5mC-DNA 3065 25942 METALLOPROTEASE DUBS%REACTOME DATABASE ID RELEASE 95%5689901 Metalloprotease DUBs 8027 114548 114803 10617 8331 672 8337 79184 8334 57559 8335 2033 29086 317772 7311 221613 7314 85235 8850 6233 84142 3013 9577 580 51720 92815 23172 8338 7316 8969 10213 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%R-HSA-452723.4 Transcriptional regulation of pluripotent stem cells 4087 6299 4089 55211 2516 2247 2034 6657 5087 2041 6774 64344 63978 6997 27022 7547 5460 57167 84891 79923 79727 9314 RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%8931987 RUNX1 regulates estrogen receptor mediated transcription 8312 861 865 57678 200845 2099 HORMONE LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-375281.4 Hormone ligand-binding receptors 3972 3973 2798 2797 2796 122876 170589 7252 7253 2488 2492 1081 DEFECTIVE SLCO1B1 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME%R-HSA-5619110.4 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) 10599 DISORDERS OF NERVOUS SYSTEM DEVELOPMENT%REACTOME DATABASE ID RELEASE 95%9697154 Disorders of Nervous System Development 2874 79718 3065 25942 9612 814 808 8841 9611 5566 6907 MECP2 REGULATES TRANSCRIPTION OF NEURONAL LIGANDS%REACTOME DATABASE ID RELEASE 95%9022702 MECP2 regulates transcription of neuronal ligands 28514 3065 25942 1392 627 6750 SIGNALLING TO STAT3%REACTOME DATABASE ID RELEASE 95%198745 Signalling to STAT3 4803 6774 4914 NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY%REACTOME DATABASE ID RELEASE 95%168333 NEP NS2 Interacts with the Cellular Export Machinery 23636 9631 7175 9972 11097 23279 8086 23511 53371 8480 79023 79902 10762 5903 5901 348995 9883 6396 129401 9688 57122 7514 23225 4927 23165 55746 8021 55706 G-PROTEIN ACTIVATION%REACTOME DATABASE ID RELEASE 95%202040 G-protein activation 2782 2788 2787 2786 55970 2776 2785 2784 2783 51764 10681 5173 4988 54331 2767 59345 9630 94235 5443 2793 2792 2791 2769 2790 FERTILIZATION%REACTOME DATABASE ID RELEASE 95%1187000 Fertilization 7784 49 157855 22917 100129669 257062 2683 117144 284359 5016 57828 8747 8748 84329 57829 347732 126123 2515 117155 79820 113177 6677 928 7783 378807 11085 P2Y RECEPTORS%REACTOME%R-HSA-417957.5 P2Y receptors 2846 27334 10161 5028 5030 53829 5029 64805 5031 5032 9934 2840 CTNNB1 S45 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358751.4 CTNNB1 S45 mutants aren't phosphorylated 5515 5516 5518 1499 5525 5526 8312 2932 5527 324 5528 1452 5529 139285 5519 FRS-MEDIATED FGFR3 SIGNALING%REACTOME%R-HSA-5654706.5 FRS-mediated FGFR3 signaling 8074 2249 2247 10818 2246 10817 8823 8817 26281 5781 6654 4893 2254 3265 ACTIVATION OF PKB%REACTOME DATABASE ID RELEASE 95%165158 Activation of PKB 117145 208 57761 5170 FORMATION OF THE DYSTROPHIN-GLYCOPROTEIN COMPLEX (DGC)%REACTOME DATABASE ID RELEASE 95%9913351 Formation of the dystrophin-glycoprotein complex (DGC) 3918 284217 3908 3909 3910 3911 3912 1756 375790 6645 3339 7402 137868 6443 6442 6445 6444 1605 8082 1821 54221 1838 1837 8910 3913 3914 3915 6641 10319 6640 INFECTION WITH ENTEROBACTERIA%REACTOME%R-HSA-9640148.3 Infection with Enterobacteria 2633 7311 115361 3040 11045 7314 163351 4072 808 2634 837 7322 6233 3043 7316 TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME%R-HSA-5676594.3 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 329 4049 10673 8740 8600 8792 4055 330 8742 4050 115650 51330 959 7187 9020 7186 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME%R-HSA-1480926.4 O2 CO2 exchange in erythrocytes 51706 760 6005 6521 762 3040 759 606495 51167 358 51700 3043 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN EXPRESSION%REACTOME%R-HSA-1368108.9 BMAL1:CLOCK,NPAS2 activates circadian expression 56938 5469 79365 8553 4862 10498 551 6907 80205 8648 79718 406 85441 10499 10135 96764 5054 28999 9575 25819 1387 23054 2155 5465 6256 6604 REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS%REACTOME%R-HSA-9614399.2 Regulation of localization of FOXO transcription factors 208 10000 2810 2309 7532 207 4303 7534 2308 7529 10971 DRUG-MEDIATED INHIBITION OF MET ACTIVATION%REACTOME DATABASE ID RELEASE 95%9734091 Drug-mediated inhibition of MET activation 4233 3082 BETA-KETOTHIOLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9915355 Beta-ketothiolase deficiency 38 KERATAN SULFATE BIOSYNTHESIS%REACTOME%R-HSA-2022854.4 Keratan sulfate biosynthesis 2683 4060 11081 8534 23563 93010 4969 10678 2331 8703 8704 8702 176 4166 11041 9435 4958 79369 5549 9334 9331 11046 9469 10331 10402 6483 6482 6484 6487 VIRAL MRNA TRANSLATION%REACTOME DATABASE ID RELEASE 95%192823 Viral mRNA Translation 5611 6233 6152 6155 6154 6157 9349 6156 6159 6158 23521 51121 6175 11224 6164 200916 6166 6122 6165 6124 6168 6123 6167 6169 6125 116832 25873 6160 6161 140801 4736 6130 6133 9045 6230 6232 6132 6210 6176 6231 6135 6234 6134 6235 6137 6191 6136 2197 6193 6171 6192 6170 6194 6173 51065 6128 140032 6129 6205 6142 6227 6141 6204 6144 6207 6143 6229 6146 6206 6147 6228 6181 6139 6209 6138 6208 6188 7311 6187 6223 6201 6189 6222 6203 6224 6202 6218 6217 3921 2926 PLUS-STRAND DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%164525 Plus-strand DNA synthesis 5478 BLOCKAGE OF PHAGOSOME ACIDIFICATION%REACTOME%R-HSA-9636467.2 Blockage of phagosome acidification 51606 MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME%R-HSA-6791226.5 Major pathway of rRNA processing in the nucleolus and cytosol 25926 114049 27340 10436 27341 57647 88745 10199 9136 22984 57050 55272 51077 10607 11056 9724 84135 134430 51118 10885 55720 5394 28987 8780 4809 54881 26168 81875 79159 51388 90459 8568 55759 10528 705 79707 57418 23246 23481 26354 55131 6152 81887 6155 84946 6154 10438 6157 55781 9349 117246 6156 83732 6159 10969 6158 10200 23521 51121 11224 6164 200916 6166 6122 6165 6124 6168 6123 6167 6169 6125 116832 25873 6160 6161 23517 140801 4736 6130 6133 9045 6230 6232 6132 6210 6176 6231 6135 6234 6134 27043 6235 6137 6191 6136 2197 6193 6171 6192 6170 6194 6173 6128 51065 4691 6129 140032 6142 6205 6227 6141 6144 6204 6143 6207 6229 6146 6147 6206 6228 6181 6139 6138 6209 6208 6188 6187 6223 6201 6189 6222 6203 6224 6202 6218 6217 3921 79897 11102 54913 9188 10799 6233 10557 11340 23404 10556 54512 6175 5393 23016 1454 1453 51010 51013 118460 51602 22894 56915 7311 10171 79050 84916 23160 10813 27042 55127 54555 84128 51202 8602 92856 11103 65083 9277 25879 9790 51096 55813 22803 5822 56902 2091 METABOLISM OF FOLATE AND PTERINES%REACTOME%R-HSA-196757.8 Metabolism of folate and pterines 4524 113235 10840 10797 10588 6472 25902 6573 160428 1719 2350 441024 6470 200895 81034 4522 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 95%354194 GRB2:SOS provides linkage to MAPK signaling for Integrins 2244 2266 54518 5906 5908 7450 2243 7094 3690 3674 5747 6714 6654 2335 DEFECTIVE PRO-SFTPC CAUSES SMDP2 AND RDS%REACTOME DATABASE ID RELEASE 95%5688354 Defective pro-SFTPC causes SMDP2 and RDS 6440 FORMATION OF THE POSTERIOR NEURAL PLATE%REACTOME%R-HSA-9832991.2 Formation of the posterior neural plate 5453 25925 5015 6656 2253 6911 2637 6657 9839 89780 DEFECTIVE ST3GAL3 CAUSES MCT12 AND EIEE15%REACTOME DATABASE ID RELEASE 95%3656243 Defective ST3GAL3 causes MCT12 and EIEE15 176 4958 5549 4060 11081 4969 6487 2331 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%R-HSA-6782210.3 Gap-filling DNA repair synthesis and ligation in TC-NER 10450 91603 7874 6233 57654 9978 27339 7316 5440 5441 4331 1022 2071 2966 1161 2965 9716 2068 5434 5435 5436 5437 5438 10714 5439 5424 2968 8451 5425 2967 5981 404672 57804 5430 3978 5431 5432 5982 5433 56655 902 5983 7515 6917 5426 5427 3980 57461 51426 1642 54107 7311 2074 5111 7314 56949 6117 5984 5985 6119 6118 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 95%201722 Formation of the beta-catenin:TCF transactivating complex 474382 7088 7089 3065 84661 54145 7091 11091 83439 1499 51176 5929 6932 7015 6934 4221 4609 9070 8295 8607 8313 9757 90780 283149 8970 8331 26108 8337 128312 1387 607 8334 8335 6597 2033 8370 55766 8968 8341 8342 8347 8290 79577 8348 94239 7090 8345 3013 123169 8340 10524 8338 255626 3021 653604 864 3018 3017 85236 3014 8349 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME%R-HSA-388844.4 Receptor-type tyrosine-protein phosphatases 84189 8541 8497 8499 114798 8500 94030 5792 84631 139065 26050 8495 8496 5789 22865 26280 11141 5802 4916 DEGRADATION OF GABA%REACTOME%R-HSA-916853.4 Degradation of GABA 18 7915 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME%R-HSA-9630794.4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 1029 1021 1019 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 95%418592 ADP signalling through P2Y purinoceptor 1 2782 2788 2787 5321 2786 55970 2776 2785 5028 2784 2783 51764 10681 54331 2767 59345 9630 94235 2793 2792 1432 2791 2769 2790 AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%R-HSA-141424.4 Amplification of signal from the kinetochores 54821 378708 1781 23122 1780 79172 1778 81930 55920 84643 3796 9793 91687 57551 79682 5905 1783 5501 83540 80152 2491 5519 332 55143 699 11243 3619 140735 5515 11004 5516 5518 9212 25936 11130 64946 79980 348995 10726 6396 5525 5526 55839 5527 5528 7514 57122 5529 55746 23279 79023 79902 5903 54908 6232 8655 5347 25909 8379 9183 1063 1062 9184 1060 991 151648 55166 1058 79019 151246 9735 23332 79003 55055 81565 22919 348235 5048 23421 220134 57082 57405 51143 147841 4085 64105 401541 10403 6249 54820 80776 701 DEFECTIVE SLC26A4 CAUSES PENDRED SYNDROME (PDS)%REACTOME DATABASE ID RELEASE 95%5619046 Defective SLC26A4 causes Pendred syndrome (PDS) 5172 METABOLISM OF AMINE-DERIVED HORMONES%REACTOME%R-HSA-209776.5 Metabolism of amine-derived hormones 5409 7054 1644 1621 50506 7252 53905 405753 857 15 51061 7173 121278 7166 1734 438 1733 389434 90527 6528 1735 1081 LORLATINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717329.2 lorlatinib-resistant ALK mutants 238 DEFECTIVE ACY1 CAUSES ENCEPHALOPATHY%REACTOME DATABASE ID RELEASE 95%5579007 Defective ACY1 causes encephalopathy 95 SIGNALING BY PHOSPHORYLATED JUXTAMEMBRANE, EXTRACELLULAR AND KINASE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9670439.2 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 8503 6776 3815 4067 6774 5295 5296 6772 7525 2534 6654 4893 5290 3932 6777 3265 3717 MPS VII - SLY SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953080.1 MPS VII - Sly syndrome (CS DS degradation) 2990 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME%R-HSA-420499.4 Class C 3 (Metabotropic glutamate pheromone receptors) 259289 50840 50835 259287 259286 259285 2914 259293 80835 259294 259292 80834 353164 259290 5726 222545 259296 259295 2911 846 2915 83756 50831 50833 50832 50834 9568 50837 338398 50836 50839 50838 2918 2917 2550 2916 2913 2912 54429 SIGNALING BY AXIN MUTANTS%REACTOME DATABASE ID RELEASE 95%4839735 Signaling by AXIN mutants 5515 5516 5518 5525 5526 8312 2932 5527 324 5528 1452 5529 139285 5519 DNA DAMAGE RECOGNITION IN GG-NER%REACTOME%R-HSA-5696394.2 DNA Damage Recognition in GG-NER 7528 60 142 1069 8451 8533 29844 125476 64708 2873 10987 51138 9318 10980 50813 283899 10038 83444 54891 10920 1642 10445 7311 7508 7314 1643 79913 6233 54617 9978 7316 8607 93973 5886 4798 5887 86 DAG1 CORE M1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 95%8932506 DAG1 core M1 glycosylations 29954 10585 55624 1605 DRUG-MEDIATED INHIBITION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 95%9652282 Drug-mediated inhibition of ERBB2 signaling 11140 3320 2064 55914 INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME%R-HSA-512988.8 Interleukin-3, Interleukin-5 and GM-CSF signaling 3561 3716 29760 867 6776 5566 1399 5295 3562 5296 3559 3558 6464 2534 6850 5781 3636 3055 5290 5291 8503 9846 5777 2889 5293 1398 1437 3563 3560 4067 3635 7006 1439 7525 1438 7409 3568 3718 6654 7534 3567 6777 3717 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 95%156842 Eukaryotic Translation Elongation 1938 6233 6152 6155 6154 6157 9349 6156 6159 6158 23521 51121 6175 11224 6164 1917 200916 6166 6122 6165 6124 6168 6123 6167 6169 1937 6125 1936 116832 25873 1933 6160 6161 140801 4736 6130 6133 9045 6230 6232 6132 6210 6176 6231 6135 6234 6134 6235 6137 6191 6136 2197 6193 6171 6192 6170 6194 6173 51065 6128 140032 6129 6205 6142 6227 6141 6204 6144 6207 6143 6229 6146 6206 6147 6228 6181 1915 6139 6209 6138 6208 6188 7311 6187 6223 6201 6189 6222 6203 6224 6202 6218 6217 3921 LOSS-OF-FUNCTION MUTATIONS IN DBT CAUSE MSUD2%REACTOME DATABASE ID RELEASE 95%9865113 Loss-of-function mutations in DBT cause MSUD2 594 1629 1738 593 REGULATION OF SIGNALING BY NODAL%REACTOME%R-HSA-1433617.3 Regulation of signaling by NODAL 55997 130399 6998 91 199699 92 9350 93 6997 7044 4838 10637 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3304356 SMAD2 3 Phosphorylation Motif Mutants in Cancer 7046 4087 4088 7048 7040 INHIBITION OF PKR%REACTOME DATABASE ID RELEASE 95%169131 Inhibition of PKR 5610 DEVELOPMENTAL CELL LINEAGES%REACTOME DATABASE ID RELEASE 95%9734767 Developmental Cell Lineages 2252 3918 2255 284217 3908 1950 3909 7448 3910 3911 2249 3912 2247 7039 374 3913 3914 3915 2335 5617 10319 REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME%R-HSA-6804760.3 Regulation of TP53 Activity through Methylation 2033 133383 387893 7311 91875 7314 6233 26013 79813 56950 7316 10419 10919 11200 4194 472 7157 133746 4193 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME DATABASE ID RELEASE 95%174113 SCF-beta-TrCP mediated degradation of Emi1 5706 5707 5708 5709 5700 5701 5702 51343 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 991 11047 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 9861 8454 6233 5687 5688 5689 7316 6500 10213 26271 8945 SPOP-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME%R-HSA-9929491.1 SPOP-mediated proteasomal degradation of PD-L1(CD274) 5706 5707 5708 5709 595 1019 5700 8452 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 1460 11047 5713 1459 5714 5690 5691 1457 5692 5693 5694 7311 7979 7532 5695 7314 9861 6233 8405 5687 5688 9978 5689 7316 10213 29126 MICROBIAL MODULATION OF RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-HSA-9686347.3 Microbial modulation of RIPK1-mediated regulated necrosis 11035 8737 197259 841 WNT MEDIATED ACTIVATION OF DVL%REACTOME%R-HSA-201688.2 WNT mediated activation of DVL 1459 1454 1457 1857 1856 8395 1855 1460 APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME DATABASE ID RELEASE 95%179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 9861 6233 7316 10213 51529 7321 5706 8881 64682 5707 25906 5708 11065 8697 5709 7324 10393 29945 27338 119504 5700 5701 29882 5702 246184 983 996 5704 51434 5705 51433 5682 5683 5684 4751 5685 5686 5717 9184 5718 5719 991 11047 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 5687 5688 5689 4085 890 8900 701 ANTI-INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION%REACTOME%R-HSA-9662851.3 Anti-inflammatory response favouring Leishmania parasite infection 113 114 115 5045 107 108 55970 109 196883 5566 5567 5568 10800 2268 54331 6868 79651 3710 136 59345 9332 2781 4627 346562 2212 2782 64174 808 10681 4067 2778 2771 2770 3708 3709 2773 2678 5335 2687 10769 917 2209 3586 2793 2792 5573 2534 6850 1432 5575 2791 3055 5576 5577 2790 5613 2214 2788 10768 2787 2786 2785 1800 2784 2783 3569 51764 57105 7525 94235 5336 111 112 DEFECTIVE SLC33A1 CAUSES SPASTIC PARAPLEGIA 42 (SPG42)%REACTOME%R-HSA-5619061.3 Defective SLC33A1 causes spastic paraplegia 42 (SPG42) 9197 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 95%1253288 Downregulation of ERBB4 signaling 4734 7316 7311 6714 7314 83737 11059 6233 SENSORY PERCEPTION OF SWEET, BITTER, AND UMAMI (GLUTAMATE) TASTE%REACTOME%R-HSA-9717207.2 Sensory perception of sweet, bitter, and umami (glutamate) taste 259289 50840 259287 259286 259285 2914 259293 80835 259292 80834 259290 5726 259296 259295 3710 2911 346562 6324 2782 6330 6335 2784 5330 51764 83756 6326 54795 6328 6327 50831 50833 50832 50834 50837 50836 255022 29850 50839 119395 50838 54429 GLYCOGEN METABOLISM%REACTOME%R-HSA-8982491.3 Glycogen metabolism 2548 5261 378884 5260 8908 5834 7957 5836 83592 2992 5837 5255 5256 5257 2998 2632 5507 7311 7314 808 6233 7360 178 7316 5236 2997 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (MACROPHAGES)%REACTOME%R-HSA-5619049.3 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) 1356 30061 EXTRA-NUCLEAR ESTROGEN SIGNALING%REACTOME DATABASE ID RELEASE 95%9009391 Extra-nuclear estrogen signaling 55970 595 54331 4313 4846 59345 5295 5296 346562 5290 5170 6722 2782 3276 808 10681 8877 7514 2771 6714 2770 2100 1903 2773 3320 1950 6801 4318 1956 207 2099 1027 5590 374 2793 596 2792 2791 4893 2790 8503 2788 2787 2786 2785 340481 2784 5594 2783 5595 857 55625 51764 4314 7039 2353 685 127933 3480 858 255324 2069 208 2002 10000 2309 4316 5747 94235 1839 3265 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 95%418890 Role of second messengers in netrin-1 signaling 7220 7222 5335 7224 7223 57113 7225 5306 1630 9423 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL3%REACTOME DATABASE ID RELEASE 95%9629232 Defective Base Excision Repair Associated with NEIL3 55247 STRIATED MUSCLE CONTRACTION%REACTOME%R-HSA-390522.3 Striated Muscle Contraction 4606 4607 29766 4604 1756 7431 8557 4621 7169 4624 7168 4626 7111 4632 4633 4634 4635 7125 7134 7136 7170 7135 7138 7171 7137 7140 7139 89 29767 29765 1674 4703 88 7273 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME%R-HSA-8866910.5 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 7022 7021 2064 1956 7528 7020 3815 94115 7039 2099 29028 7422 1081 SIGNALING BY ROBO RECEPTORS%REACTOME%R-HSA-376176.7 Signaling by ROBO receptors 5566 5567 4440 10921 5568 10487 4116 56956 22794 23767 89884 9939 6586 6585 3199 23053 7408 65109 1287 9355 8022 6092 6230 6210 6231 6234 6235 6191 2197 6193 6192 6194 51065 140032 5576 6205 6227 6204 1605 6207 6229 6206 6228 6209 6208 6188 6187 6223 6201 6189 6222 6203 6224 5532 6202 6218 6217 3921 5879 6655 2817 8453 9861 6233 9978 7316 6921 6923 5578 6175 10213 5062 5706 5707 5708 5709 1981 5700 5701 5702 10298 5704 23032 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 27 5713 5714 5690 5691 5692 5693 8861 5694 7311 5695 7314 26986 5687 5688 5689 5058 80728 3670 1630 9423 6152 6155 6154 6157 9901 9349 6156 6159 6158 23521 51121 25 11224 57522 6164 200916 6166 6122 6165 6124 6168 4690 6123 6167 6169 6125 116832 25873 6160 6161 9353 140801 6091 4736 5063 4650 6130 6133 57144 9045 6232 6132 6176 6135 6134 6137 6136 6171 6170 6173 6128 6129 6142 6141 6144 6143 6146 6147 998 6181 6139 6138 23332 56924 23380 8440 8829 387 6654 23122 5216 5217 9775 55110 9495 51466 6387 7852 6714 2107 23708 2935 10486 55740 22916 4686 26019 65110 7979 4753 DEFECTIVE ALG12 CAUSES CDG-1G%REACTOME DATABASE ID RELEASE 95%4720489 Defective ALG12 causes CDG-1g 79087 INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS%REACTOME%R-HSA-177243.4 Interactions of Rev with host cellular proteins 23636 9631 7175 9972 11097 23279 8086 23511 53371 4869 8480 79023 1104 79902 10762 3837 5903 5905 5902 5901 348995 9883 6396 129401 9688 57122 7514 23225 4927 23165 55746 8021 55706 VIF-MEDIATED DEGRADATION OF APOBEC3G%REACTOME DATABASE ID RELEASE 95%180585 Vif-mediated degradation of APOBEC3G 5706 5707 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 5690 5691 5692 5693 5694 8065 7311 7979 5695 7314 9861 6233 5687 5688 9978 5689 7316 6921 6923 10213 ASSEMBLY AND RELEASE OF DENGUE VIRUS VIRIONS%REACTOME DATABASE ID RELEASE 95%9918476 Assembly and Release of Dengue Virus Virions 4904 8729 9685 10945 5045 4067 7251 4691 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME%R-HSA-674695.5 RNA Polymerase II Pre-transcription Events 83860 6872 6874 6873 6881 6908 905 6880 6883 6882 6884 129685 6875 6878 8812 6877 6879 6921 6923 5440 5441 4331 1022 2071 2966 6829 2965 2963 8148 2962 2068 5434 5435 51616 5436 5437 5438 5439 2968 8178 2967 22916 404672 5430 25920 4686 5431 138474 5432 54457 51224 5433 6924 7936 902 6827 6749 9150 6917 1025 51497 2961 7469 11198 2960 2959 904 2958 2957 4298 6830 27125 23168 55840 4300 85403 79577 55677 80349 123169 9646 54623 POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 95%110362 POLB-Dependent Long Patch Base Excision Repair 3978 10038 2237 5423 142 8505 54936 328 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 95%400451 Free fatty acids regulate insulin secretion 23236 2864 2767 2776 9630 2182 5330 5331 2181 2769 948 MITOCHONDRIAL MRNA MODIFICATION%REACTOME DATABASE ID RELEASE 95%9937008 Mitochondrial mRNA modification 81554 10128 51335 81892 84881 55149 22868 285367 26995 51001 55006 INACTIVATION OF CDC42 AND RAC1%REACTOME%R-HSA-428543.4 Inactivation of CDC42 and RAC1 23380 998 5879 9901 80728 9353 6091 57522 TRANSLESION SYNTHESIS BY POLH%REACTOME DATABASE ID RELEASE 95%110320 Translesion Synthesis by POLH 83932 7353 7311 5111 7314 6233 5981 5982 6117 5984 7316 5983 7415 5985 6119 5429 6118 55666 DEFECTIVE GALT CAN CAUSE GALCT%REACTOME DATABASE ID RELEASE 95%5609978 Defective GALT can cause GALCT 2592 SOMITOGENESIS%REACTOME DATABASE ID RELEASE 95%9824272 Somitogenesis 5706 5707 5708 5709 6911 5700 5701 5702 1499 51176 5704 5705 5682 2043 5683 5684 5685 5686 5717 5718 5719 11047 3516 5713 5714 5690 28514 5691 5692 5693 5694 84667 7979 343930 5695 134701 3955 145873 10683 9861 5687 5688 5689 4851 10213 SIGNALING BY FGFR2 IN DISEASE%REACTOME%R-HSA-5655253.3 Signaling by FGFR2 in disease 2252 2251 8074 2963 5335 2962 2249 5434 5435 2248 5436 2247 5437 5438 2246 5439 2263 22916 5430 4686 5431 5432 5433 8823 5295 4893 5290 27006 2255 2549 10818 8817 26281 5440 5441 6654 2254 3265 NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013695.2 NOTCH4 Intracellular Domain Regulates Transcription 2033 4088 84441 23462 8850 3280 10046 4851 4853 4855 59 388585 2324 9794 2648 22938 23493 1387 3516 55534 DOWNSTREAM TCR SIGNALING%REACTOME%R-HSA-202424.6 Downstream TCR signaling 3551 6885 23118 5295 5296 997 10892 5290 84433 7189 5291 5170 9861 6233 7322 8767 7335 3635 920 7316 10213 50852 8945 7321 5706 5707 5708 5709 3123 3122 3120 5700 5701 5970 3119 5702 3118 3117 5728 3115 5704 3113 5705 915 5682 23291 5683 916 5684 917 5685 5686 7334 3127 5717 3126 5718 3125 5719 11047 3932 5713 5714 5690 5691 5692 8517 4792 5693 5694 7311 7979 5695 7314 4790 8454 5687 5688 5689 8915 6500 5588 1147 SDK INTERACTIONS%REACTOME%R-HSA-373756.3 SDK interactions 221935 54549 REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME%R-HSA-8943724.2 Regulation of PTEN gene transcription 57459 2146 3065 23186 54815 23028 10014 5928 51564 389541 8841 28956 1958 57521 8535 55004 8649 7157 6045 1107 10670 6009 648 5931 6015 23466 6591 3066 64121 64223 1912 1911 153129 23512 80012 57332 2475 84733 58528 10542 2122 10325 1822 84232 8726 7101 57167 1108 9219 57504 5468 9112 53615 5978 5594 5595 1386 3725 6615 CYTOPROTECTION BY HMOX1%REACTOME DATABASE ID RELEASE 95%9707564 Cytoprotection by HMOX1 25942 213 2168 81502 10498 1327 6907 8648 79718 9377 9612 1329 8841 9611 1340 23054 4697 1337 341947 3040 1339 1351 9167 1350 5465 1349 1347 1346 1345 3162 5469 4512 4513 4514 80205 125965 114548 571 3163 85441 10499 96764 55620 4780 1387 7975 10628 644 645 84701 3043 6256 6774 5753 6604 54205 4363 613227 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-622323.5 Presynaptic nicotinic acetylcholine receptors 8973 1146 1143 1145 1142 1144 1141 1138 1137 1136 1135 1134 BASIGIN INTERACTIONS%REACTOME DATABASE ID RELEASE 95%210991 Basigin interactions 6566 5478 682 23759 481 23428 4312 23539 482 9123 483 3688 4099 9056 9057 6520 857 8140 23657 6693 56301 3675 3655 11136 3897 HYDROLYSIS OF LPE%REACTOME%R-HSA-1483152.5 Hydrolysis of LPE 56261 8605 INTERLEUKIN-23 SIGNALING%REACTOME DATABASE ID RELEASE 95%9020933 Interleukin-23 signaling 6774 7297 5034 6775 149233 3594 3593 3717 51561 DEFECTIVE APRT DISRUPTS ADENINE SALVAGE%REACTOME%R-HSA-9734195.2 Defective APRT disrupts adenine salvage 353 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH12 LOSS OF FUNCTION%REACTOME%R-HSA-9918440.1 Defective visual phototransduction due to RDH12 loss of function 145226 PRPP BIOSYNTHESIS%REACTOME%R-HSA-73843.4 PRPP biosynthesis 221823 5631 5634 DEFECTIVE POMGNT1 CAUSES MDDGA3, MDDGB3 AND MDDGC3%REACTOME%R-HSA-5083628.3 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 55624 1605 REGULATION OF GLYCOLYSIS BY FRUCTOSE 2,6-BISPHOSPHATE METABOLISM%REACTOME%R-HSA-9634600.5 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 5207 5208 5209 5528 5515 5516 5210 5518 5566 5567 5519 5568 BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME DATABASE ID RELEASE 95%9018676 Biosynthesis of D-series resolvins 4048 240 3248 RHO GTPASES ACTIVATE PKNS%REACTOME%R-HSA-5625740.3 RHO GTPases activate PKNs 474382 54145 23028 995 5879 4628 79784 4629 103910 4637 4627 5170 4660 10398 367 2810 5500 354 94274 7534 3817 23081 7529 5585 5586 10499 4659 8970 8331 8337 128312 8334 8335 10971 8370 55766 8968 7532 8341 8342 7531 29941 8347 8348 7533 94239 8345 3013 8340 8338 255626 5058 3021 653604 3018 387 3017 85236 388 3014 389 8349 GLYCOGEN SYNTHESIS%REACTOME%R-HSA-3322077.9 Glycogen synthesis 5507 7311 7314 6233 7360 378884 7316 8908 7957 2992 5236 2998 2997 2632 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME DATABASE ID RELEASE 95%174048 APC C:Cdc20 mediated degradation of Cyclin B 8881 64682 25906 11065 8697 7324 7311 10393 29945 7314 27338 119504 29882 891 6233 246184 983 996 51434 51433 7316 991 51529 7321 NCAM1 INTERACTIONS%REACTOME%R-HSA-419037.4 NCAM1 interactions 783 5623 375790 6900 64096 4902 9048 5621 775 1297 779 8912 8913 8911 1284 1282 1286 1285 256076 782 784 8128 785 131873 4684 1293 7903 1292 1291 2668 2675 776 2674 1463 1287 1299 1298 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME%R-HSA-430116.3 GP1b-IX-V activation signalling 2316 2811 5894 2812 5295 7450 2815 2814 7534 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%R-HSA-193368.4 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 8647 1646 1645 6718 1109 1582 3295 10998 1581 9971 11001 9420 8648 10005 6256 10499 8644 80270 570 23600 1593 8309 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%R-HSA-202733.7 Cell surface interactions at the vascular wall 6566 7040 682 4072 481 4312 482 483 4099 54210 338 5175 2335 7010 284 5335 3512 51206 57126 23759 9046 23428 50848 5196 5781 4893 9056 83700 9057 6520 8140 23657 6693 7441 56301 440533 914 3690 5670 7056 11136 5671 3685 5672 5673 3897 6401 3678 90952 5675 51378 9463 5669 10544 8795 5680 6654 8832 29802 8793 3265 5676 8797 5678 6404 1525 634 2734 3543 83953 120425 5197 4267 285 3687 2995 2994 962 2993 10461 4973 2888 2207 972 83692 51744 7102 1048 23539 9123 6383 5295 5296 3688 9672 6464 6385 5290 5291 6382 3684 58494 2817 960 2886 961 965 4067 3635 3689 4680 5478 3683 4282 140885 1088 1084 3676 2534 6402 3932 2621 2147 5777 5624 5627 857 55423 3675 3655 7525 6403 ACTIVATION OF RAC1%REACTOME%R-HSA-428540.6 Activation of RAC1 4690 9353 6091 5063 10298 57144 56924 5879 5058 8440 6655 6654 5062 TGFBR3 REGULATES ACTIVIN SIGNALING%REACTOME%R-HSA-9839406.1 TGFBR3 regulates activin signaling 7049 92 3624 3623 INTERLEUKIN-37 SIGNALING%REACTOME DATABASE ID RELEASE 95%9008059 Interleukin-37 signaling 5771 5783 26469 29110 5777 25930 59307 4088 5775 5780 5782 5784 8809 5778 6774 834 84867 26095 5781 27178 10068 RHOG GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013408 RHOG GTPase cycle 11135 1969 55914 23263 9217 80005 4168 27237 5295 3688 4722 55004 4296 63916 26030 3954 1795 6811 1794 10788 1793 26286 7444 2909 3336 9743 57584 392 3895 9341 394 5062 397 4698 7879 10298 10652 3998 9710 396 81839 398 5337 1829 10424 998 7204 9732 2010 23344 6472 143098 57580 4983 857 8987 3930 55789 10451 7410 4162 26084 7112 7037 23141 80728 7409 23191 391 81624 23592 8997 6453 7984 REGULATION OF LIPID METABOLISM BY PPARALPHA%REACTOME DATABASE ID RELEASE 95%400206 Regulation of lipid metabolism by PPARalpha 11010 335 336 183 1581 10498 5244 84498 405 196 406 10025 27242 9968 9969 892 10001 27063 5465 29079 1579 57491 5468 5469 6822 1543 4899 9862 29841 2033 3992 376497 2274 9572 26230 3158 2180 6256 6604 90390 25942 2168 6257 6095 57761 6907 51003 8648 79718 84246 7376 9612 10062 10891 8841 9611 19 123 23054 9443 9441 2874 9442 54797 55090 9440 211 8202 80306 133522 51586 948 9439 9971 23097 6837 219541 23389 1376 55588 9412 4199 400569 9915 9967 81857 7296 9477 112950 4862 1374 23179 80205 8800 85441 10499 2101 96764 9575 1387 2222 6667 34 3157 6721 1024 4520 4800 4801 4802 51129 54600 50486 9282 116519 MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS%REACTOME DATABASE ID RELEASE 95%174490 Membrane binding and targetting of GAG proteins 7311 7314 55048 89853 6233 137492 51271 51160 155382 93343 7251 79720 7316 9397 SARS-COV-1 INFECTION%REACTOME%R-HSA-9678108.8 SARS-CoV-1 Infection 7706 59272 7187 64398 7189 1655 3661 340061 29110 143 2931 56965 83666 84875 79668 54956 54625 81631 80143 7405 9641 79643 10465 51652 91782 92421 4869 5970 64135 3837 6230 6232 11035 6210 6231 6234 6235 6191 2197 7415 6193 6192 5925 6194 27243 51065 128866 140032 6205 6227 6204 29082 10971 6207 6229 2033 6206 6228 1915 25978 6209 6208 6188 6187 6223 6201 6189 30849 6222 6203 6224 6202 3178 6218 6217 3921 5289 7841 861 85437 3656 4245 23193 821 5589 5170 7341 29108 6441 7329 5479 2280 6233 57506 11123 2932 7316 9111 10610 2810 6483 9868 6482 26007 6484 7428 6487 8678 7534 5706 6480 5478 256435 4088 4089 83737 27090 7529 5094 114548 1514 834 598 6667 3838 4792 7311 7532 23586 7314 7531 4790 857 7533 684 51284 2589 7113 9360 NETRIN MEDIATED REPULSION SIGNALS%REACTOME DATABASE ID RELEASE 95%418886 Netrin mediated repulsion signals 90249 8633 6714 137970 5781 1630 219699 9423 REGULATION OF TBK1, IKKΕ-MEDIATED ACTIVATION OF IRF3, IRF7 UPON TLR3 LIGATION%REACTOME DATABASE ID RELEASE 95%9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 10133 10010 9641 29110 7098 7316 7311 7314 7187 6233 148022 PINK1-PRKN MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 95%5205685 PINK1-PRKN Mediated Mitophagy 10452 8878 10133 100188893 7334 7417 7416 7419 401505 5071 51001 56993 29110 7311 7314 9804 54543 7323 7322 6233 65018 9927 81631 9140 55669 9474 7335 79065 84557 7332 7316 9868 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME DATABASE ID RELEASE 95%199220 Vitamin B5 (pantothenate) metabolism 79717 8884 55229 60490 2194 8034 8875 5168 5169 80025 284439 8876 254552 5167 80347 53354 79877 79646 51248 60496 RAB REGULATION OF TRAFFICKING%REACTOME%R-HSA-9007101.4 Rab regulation of trafficking 81846 23163 26088 117177 23062 11031 5874 81631 374403 57679 8766 1121 5864 5867 5868 58485 208 57589 2665 10890 51399 5873 7248 6305 22878 22879 221960 79890 84958 80006 2664 382 57465 5870 51762 23682 83874 51560 11345 25782 729873 10260 7249 6764 9230 9909 84315 51256 160518 5869 163259 22931 126432 9363 51209 79090 26130 3257 27342 5878 79958 9367 9135 201627 338382 27095 125058 163486 54662 201475 55357 7109 1122 57533 6399 11337 207 11021 7879 9827 79735 57706 126003 5872 22930 23258 79961 51693 26000 122553 10133 116442 60684 23011 83696 4218 10981 54734 5866 84079 83452 22898 54453 128637 55667 27147 51622 4943 259173 89781 23637 9610 81876 64786 5861 414918 51112 51552 7531 8408 10000 EPITHELIAL-MESENCHYMAL TRANSITION (EMT) DURING GASTRULATION%REACTOME%R-HSA-9758919.3 Epithelial-Mesenchymal Transition (EMT) during gastrulation 8320 6862 2260 6615 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 95%427359 SIRT1 negatively regulates rRNA expression 474382 54145 79101 6908 8970 8331 8337 128312 8334 8335 9014 9015 9013 8370 55766 8968 8341 8342 8347 8348 94239 8345 3013 8340 23411 8338 23378 255626 3021 6839 653604 3018 3017 85236 3014 8349 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME%R-HSA-75944.7 Transcription from mitochondrial promoters 7978 7019 64216 5442 G2 M TRANSITION%REACTOME%R-HSA-69275.7 G2 M Transition 10383 10382 91750 993 132660 7846 7465 5566 286826 9088 2305 55957 5928 7277 7157 4605 6790 8945 3320 22974 51343 8655 1063 151648 5577 2033 23332 22919 5048 55835 54820 80028 1781 23194 1778 1017 3326 994 1026 995 9793 5519 5515 5516 5518 9861 6233 9738 84962 9978 7316 9662 7840 7514 5500 11064 22994 22995 10213 7283 10733 80321 4331 203068 114791 55722 1022 1454 5706 1453 5707 5708 55125 9814 85378 5709 11190 115106 22822 79441 95681 10426 5700 5701 27175 1069 891 5702 653784 54801 983 55320 10142 51400 5704 9702 10133 10540 5705 28227 5682 5347 5108 23291 11116 5683 4218 5684 4751 5685 29922 55355 902 5686 63943 55142 3161 22897 27229 5717 51451 5718 54930 4659 5719 5520 5116 79959 90381 79596 80184 93323 79866 11047 728642 51512 23354 5713 22981 5714 440145 5690 8481 5691 10844 5692 80254 5693 121441 5694 55755 7311 984 7979 5695 10806 7532 10121 7314 7531 55559 8636 8454 11258 80097 5687 84131 5688 4957 5689 9133 890 8900 6500 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-622327.5 Postsynaptic nicotinic acetylcholine receptors 8973 1143 1142 1141 1138 55584 1137 1136 1135 1134 1146 1145 1144 89832 EPIGENETIC REGULATION OF ADIPOGENESIS GENES BY MLL3 AND MLL4 COMPLEXES%REACTOME%R-HSA-9851695.2 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 84661 11091 5929 10025 9968 9969 892 10001 9070 25 29079 5469 63924 58508 5925 8970 8331 8337 128312 9862 8334 8335 2033 8370 55766 8968 8341 8342 57678 8347 8348 94239 8345 3013 8340 8338 255626 2180 6256 3021 653604 3018 3017 85236 3014 8349 90390 60481 474382 84649 6319 1050 54145 2167 11343 6907 3991 51003 8648 79718 23175 84246 9612 10891 8841 9611 729359 123 23054 9443 22976 2874 9442 5166 5346 9440 8202 133522 948 9439 84962 79447 8085 2494 9477 22822 1020 57104 8800 10499 7069 1387 9370 1024 79611 23411 7403 51129 10555 4023 9282 MANIPULATION OF HOST ENERGY METABOLISM%REACTOME DATABASE ID RELEASE 95%9636667 Manipulation of host energy metabolism 5230 2023 DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 95%73942 DNA Damage Reversal 221120 51008 84164 10973 4255 121642 79068 54890 MITOTIC METAPHASE AND ANAPHASE%REACTOME DATABASE ID RELEASE 95%2555396 Mitotic Metaphase and Anaphase 200014 260334 79643 51652 91782 92421 3837 27243 128866 29082 25978 7341 7329 5901 9861 6233 7316 7514 10213 5706 5707 5708 5709 5700 5701 3842 5702 5704 5705 5682 5683 5684 5685 5686 113457 5717 5718 5719 7280 11047 5713 5714 5690 5691 2010 5692 5693 5694 7311 5695 7314 3930 5687 10376 5688 5689 9133 80086 51807 23592 10381 10383 10382 112714 4001 7846 1104 84790 27183 84617 347733 7277 7278 79861 81027 348995 9883 6396 129401 9688 57122 23165 55746 55706 23636 9631 23279 23511 53371 79023 79902 8815 5903 54908 6232 8655 25909 8379 9183 1063 1062 9184 1060 991 8243 151648 55166 9126 23244 23047 1058 79019 10735 151246 23063 9735 5885 10274 23332 79003 55055 81565 22919 348235 5048 23421 220134 57082 57405 51143 23141 147841 4085 64105 401541 10403 54820 80776 701 54821 378708 1781 23122 1780 79172 1778 81930 55920 84643 3796 9793 91687 57551 79682 5905 1783 5501 83540 80152 2491 5519 332 55143 699 11243 3619 140735 5515 11004 5516 5518 9212 25936 11130 64946 79980 10726 5525 5526 55839 5527 5528 5529 51529 7321 8881 64682 25906 11065 8697 7324 10393 29945 27338 119504 29882 891 246184 983 996 51434 51433 5347 5520 22933 7979 113130 9700 6683 347688 7443 9798 221496 6249 26271 9232 WAX BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%9640463 Wax biosynthesis 158833 55711 84188 158835 UCH PROTEINASES%REACTOME DATABASE ID RELEASE 95%5689603 UCH proteinases 7046 7048 7040 60 125476 51377 221656 54891 221613 9861 171023 6233 92815 4738 7316 8969 8607 93973 10213 8314 3054 7345 7347 5706 55777 5707 5708 5709 7528 3607 5700 5701 5702 5704 5705 29844 114785 5682 5683 5684 4092 5685 5686 5717 9958 5718 5719 8331 55252 8337 11047 8334 8335 5713 5714 283899 5690 83444 5691 8473 5692 5693 10445 5694 317772 7311 7979 5695 7314 79913 85235 54617 5687 3013 5688 580 5689 221937 8338 123228 4798 86 MAPK6 MAPK4 SIGNALING%REACTOME%R-HSA-5687128.5 MAPK6 MAPK4 signaling 5566 5567 5568 5879 2308 4609 4343 192669 23112 27327 26523 192670 27161 8202 57690 9861 6233 3315 7316 7514 10213 8555 10642 5062 5706 5707 2118 5708 5709 5700 5701 5063 896 5702 983 989 5896 5704 5897 5705 5682 5683 5684 5685 5686 5596 148170 5597 5717 5718 5719 11047 5713 5714 998 5690 5691 5692 5693 5694 10435 7311 7979 5695 7314 10602 5687 5688 5689 5058 2309 8556 3337 3725 8550 8997 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME%R-HSA-69563.6 p53-Dependent G1 DNA Damage Response 1029 1017 1026 7157 9861 6233 25946 7316 11200 10213 64326 4194 4193 5706 5707 5708 5709 5700 5701 5702 898 5704 5705 5682 5683 9134 5684 1027 5685 5686 5717 5718 472 5719 11047 5713 5714 5690 5691 5692 5693 5694 57060 7311 7979 5695 7314 51230 5687 5688 5689 890 8900 DEFENSINS%REACTOME DATABASE ID RELEASE 95%1461973 Defensins 117285 1235 245936 245937 140850 245938 1673 245939 1672 417 245927 613210 245928 245929 613211 81623 245930 728358 245932 245934 503841 641517 5645 644414 613209 5646 400830 504180 729230 1671 1670 245940 7097 7096 55894 1668 100133267 140881 920 1669 245913 503618 503614 245911 UREA CYCLE%REACTOME%R-HSA-70635.4 Urea cycle 435 1373 10166 83884 5009 57407 384 383 23408 162417 7157 445 DEFECTIVE SLC26A2 CAUSES CHONDRODYSPLASIAS%REACTOME%R-HSA-3560792.5 Defective SLC26A2 causes chondrodysplasias 1836 GPCR DOWNSTREAM SIGNALLING%REACTOME DATABASE ID RELEASE 95%388396 GPCR downstream signalling 553 113 554 114 115 50840 2774 107 108 109 196883 5739 5138 3710 6753 5153 116 117 5321 135 1395 5136 719 2847 2778 10846 3708 3709 50940 4852 727 728 5533 7204 55160 23365 9181 1392 128272 57580 26230 121512 1894 10451 7410 84904 100271715 26084 23370 25791 89846 9826 54848 5598 9828 7409 23229 22899 50649 8997 6453 7984 29 8874 64857 57449 389337 445328 2245 23263 50650 221472 9639 10672 10276 55701 9459 9138 4168 27237 7074 6655 136 11214 2781 5924 5729 11251 5731 5732 5733 5734 5737 6915 7252 2357 695 146850 5294 3579 23533 3577 154 2793 2792 2791 5581 2790 5582 156 5579 3838 5137 2788 10645 10768 2787 26960 2786 10636 84254 10888 2785 26086 84152 6197 2784 85397 6196 2783 8601 126006 51764 6195 8622 5141 5143 5144 5139 5151 6001 6002 5150 157 9560 11245 9630 11250 5588 94235 285601 26166 6000 2838 2843 2848 8787 29899 27115 2854 8786 2850 2870 2864 63940 2695 55970 9628 183 54331 2767 53831 59345 408 409 2769 2782 2776 10681 2919 2692 2691 9340 2740 7433 6344 7432 6343 7434 2696 5196 5140 4893 5364 8503 998 3972 5594 5595 208 387 388 6654 389 3265 6351 6352 58191 6357 2826 10850 6364 6363 6366 1230 5583 6360 2833 9162 643 8527 10663 26090 8525 6373 8526 6372 5295 57406 3688 6374 5296 221955 6376 160851 6370 1609 5519 747 2921 5290 1608 57007 2920 1607 1237 5170 1606 1236 139189 1233 3576 1232 56477 4283 5515 6387 6346 5516 10803 808 5518 10563 3627 815 7852 1234 5528 5020 6714 4295 7200 2768 816 5021 7201 431704 56413 817 818 5031 5032 6003 1909 1908 6004 94233 2798 2797 2796 1907 5028 1906 84432 5029 6375 1241 2693 1910 84109 10874 29933 222545 10887 5724 10886 257313 64407 387129 2911 2358 846 2915 4985 8111 8477 2922 5996 2147 5997 5998 5999 2925 6846 10161 185 623 351 5030 624 53829 2488 4314 140 10287 64805 134 56923 9934 8490 2151 2150 57105 2149 2829 2828 353299 885 886 887 2837 347148 9002 338557 3814 10911 2840 2846 5332 594857 64106 301 129521 128674 2867 3827 2865 2863 5566 2862 5567 60675 4922 5568 4923 10800 2869 10235 8620 10125 680 27334 84634 3060 5367 23620 3062 3061 10316 4828 4829 2642 2641 26575 5473 2520 84539 729230 7222 7225 8698 57121 9170 57113 23566 9294 1903 1902 53637 1235 1129 1128 1133 1132 1131 5499 5573 5575 5576 5577 5613 5534 5330 5331 5530 9287 3363 5532 3362 150 2780 3361 23236 151 3360 152 59340 153 155 3358 165140 3357 3356 1839 3355 1816 83551 1815 1814 1812 134864 319100 134860 9038 3354 3352 3274 3351 146 147 148 3269 4935 5956 5580 4986 4988 5578 207 1020 5726 5058 6750 133 796 797 799 718 259289 79924 3375 10266 259287 10268 259286 10267 259285 10203 9475 259293 259292 259290 6093 259296 259295 5443 2652 1081 115557 6010 54429 2779 1956 4158 80835 80834 611 221391 5995 10692 23596 3640 51083 56670 338398 3678 170589 4987 27198 27199 5741 2550 6288 2587 4886 4887 4889 122042 1394 2359 1269 1268 5744 5745 5746 2492 11343 4543 4544 259294 353164 6751 5540 6752 5539 338442 6755 10022 6754 8811 339403 346562 151306 8843 5697 256933 51289 8862 4157 4161 4160 5368 4159 117579 113091 5173 9568 2771 2770 6019 1524 7253 2918 2917 2916 2913 2912 2773 8484 186 187 50835 2832 2831 122876 1880 283869 2841 2914 2853 551 2852 50865 2861 9283 3973 9290 59350 1325 6870 6863 6865 6866 6869 814 83756 50831 50833 50832 10000 50834 5179 50837 50836 50839 50838 5660 111 552 112 DEVELOPMENTAL BIOLOGY%REACTOME%R-HSA-1266738.19 Developmental Biology 5915 5916 84661 11091 1435 5928 5929 4313 10570 1809 56896 1400 4850 1808 3516 4848 4849 5931 9070 1346 1108 5970 3549 10765 58508 64321 6736 1605 5979 7204 23365 10451 7410 6601 6603 25791 6602 9826 6605 6604 91584 8997 6453 57459 8874 51003 5879 7074 4208 6655 7341 7022 7021 7329 5362 7020 10371 2242 23396 8453 6237 55558 728279 2034 3880 404203 84962 3881 9978 286887 3882 353323 337879 6921 100288323 6923 83902 54474 64344 337882 337880 81850 5440 81851 3872 5441 11187 3875 643812 140807 643394 6662 3890 3891 2064 3892 4318 353332 353333 5434 121391 5435 83901 5436 83900 2312 5437 3883 5438 3884 5439 3885 6657 3886 3887 3888 5430 3889 5431 728299 5432 162605 5433 5788 337979 337978 337977 337976 8851 337975 448835 100132386 81870 81871 1460 1475 81872 140258 1459 196374 8688 8689 1457 8687 337969 8861 337967 337966 337974 7532 337973 337972 7531 254910 337971 7533 337970 144501 390792 387264 337959 112802 337963 23411 6707 3174 337960 353132 353131 6700 6701 7525 6704 5588 6703 6706 6705 728224 100505753 353134 23254 353133 353135 353137 353139 7305 26085 126638 440051 353141 440050 60 149018 353140 353143 353142 1825 1824 1823 728255 353145 353144 1041 23581 2125 100507608 11005 9968 147409 9969 9333 5652 387273 51350 192666 254950 7157 51316 387266 387267 340654 728318 353288 25984 440021 125115 643414 100505724 643418 43847 43849 7051 199834 388818 7062 83899 83895 83897 83896 100533177 9119 6768 23114 11202 5318 147183 25 338785 440023 284827 653240 84616 100131902 85291 85290 85293 4014 26239 84648 386684 386683 386685 85294 3713 85280 319101 374454 53615 63036 386680 6232 386682 386681 386677 50937 85456 3848 3849 386679 386678 386672 386675 57830 9794 386674 8463 342574 85289 9314 3846 85285 6698 998 3860 3858 3859 3850 142910 23332 9337 3851 3852 3853 3854 3855 3856 3857 5493 25818 439915 100132476 10046 23380 3861 6699 643803 3866 3868 387 388 389 5077 90390 23122 9125 6348 5216 5217 8289 3688 6722 51466 71 6387 2516 133522 1729 8085 286 4140 4897 6900 55740 8828 7094 22916 4686 2534 4651 79923 7484 6928 1595 153572 6721 5455 28514 79192 182 3975 54361 7490 3172 3955 4174 5087 1213 4171 1211 7436 51129 4023 776 160 30011 161 7430 163 783 5909 5962 5566 5567 5568 4628 1175 79784 1173 4629 1785 10507 3400 3984 3985 23414 103910 4637 4664 4627 4665 1959 23405 3397 6477 130399 7220 91 92 7222 93 8928 7224 7223 10589 7225 4308 5829 57113 7408 3913 8650 3914 3915 2051 2335 2050 2049 10319 57504 3918 2048 284217 655 2047 1949 3908 9112 64641 1948 3909 7448 1947 63976 3910 7350 3911 23090 3912 8515 89780 6230 6210 6231 6234 6235 6191 2197 6193 2766 6192 6194 51065 5460 140032 5576 6205 6227 6204 6207 4772 6229 7481 6206 6228 6209 5076 6208 6188 6495 6187 6299 2296 6223 3207 6201 6189 10736 255743 6222 2303 6203 3227 6224 3237 5532 6202 26585 6218 6217 3921 4851 2645 1272 3326 8600 2058 1975 1977 112755 2909 5062 10298 1829 27 4211 3200 9063 9935 3211 3201 10664 3221 5058 63925 3214 28964 3213 80728 3212 2260 5316 3233 3232 3198 3231 1969 3375 7040 7290 8459 57453 1630 9423 5617 1826 1284 1282 6152 6155 6154 9043 1013 6157 9901 1496 9349 6156 4207 6925 6159 6158 4617 23521 4618 51121 663 11224 4917 57522 1002 6164 4654 200916 6166 4656 6122 6165 6124 6168 6123 6167 6169 6125 116832 25873 6160 6161 140801 4736 5063 4650 6130 6133 57144 9045 6132 6176 6135 6134 6137 6136 6171 6170 6173 3728 2138 6128 8976 6129 6517 6142 6141 168544 6144 1879 6143 7124 6146 7480 6147 10974 6181 27332 6139 7026 1052 6138 3169 145258 56924 3690 83881 3680 4684 3685 3674 3897 3678 8829 5604 5605 6469 50846 1299 1298 2167 375790 5054 3673 1297 22885 8516 84448 3983 23054 1107 22976 54797 29128 55090 3066 4157 80306 8202 4161 23512 4160 948 4159 200424 23097 7703 5977 6837 219541 23389 2932 55588 9412 79447 400569 605 2107 8110 23708 10486 2935 51520 1615 3376 7965 9521 9255 26039 26019 5859 4141 10499 65110 6760 5917 22797 374 3735 7545 596 27022 257 6926 1387 4286 7030 9370 9274 7039 9275 7403 10000 8193 2309 5747 63978 6997 3725 7547 84891 79727 1759 8218 4099 427 6300 53358 26052 5730 6386 1149 5453 5015 6656 6709 2253 6911 2637 4838 10637 1828 55997 6998 1832 199699 1830 90249 9350 5317 84667 343930 134701 145873 10683 219699 5598 3651 102 390874 5663 256297 3175 23385 4825 55851 5664 83464 51107 201595 6383 50674 4185 9211 163175 55203 8745 203190 53616 6591 2817 3170 6478 6927 4821 4760 389692 4067 222546 3171 3642 6175 6775 9967 4086 4087 4088 4089 3595 23032 1072 4478 5306 9421 93649 150572 2627 8320 6862 57057 55897 6899 5293 6197 6196 9252 4303 6195 4205 3672 3670 5080 86 387332 57526 30009 10406 85358 3203 7849 84059 4359 57716 4155 344022 84498 268 5081 9241 1761 2657 2018 57211 4487 3156 5376 7546 130497 64283 782 784 785 8850 27289 2625 2122 6711 57167 4690 7528 8502 2648 5781 4893 5361 5364 8503 9855 3630 2549 9114 51606 8660 5594 5595 2294 10818 9550 9839 523 526 6663 1495 527 208 528 8440 24137 529 8992 6615 6654 23129 2254 3265 2252 597 634 7837 7299 79083 2315 2249 3662 2887 1000 2247 6490 1638 5454 533 10085 6935 727936 4644 7015 5873 79444 54843 9775 25924 7391 5295 7306 5296 55110 6464 5290 5291 2255 9846 2886 1742 1741 1793 8106 1739 7852 2904 6714 2902 285643 22938 1908 1906 891 10048 1910 5347 672 7044 7979 10524 2668 2676 2675 2674 10752 285220 4753 4756 6708 57556 100133941 2596 6710 5623 6712 971 148738 137970 64096 5266 4440 10921 57698 5649 2045 2044 10487 2043 2042 4116 2041 5786 116986 64218 775 2046 779 56956 56963 23767 22794 8986 6324 6323 11313 1286 89884 1285 54209 6331 256076 6330 9939 8633 9723 6332 5365 6335 6334 214 6326 8506 131873 6328 6327 6329 6586 1293 6585 1292 3199 1291 57731 6336 23053 11280 59277 220164 55800 65109 1943 287 1287 1942 288 51332 1946 1945 55816 1944 10154 8482 1600 55715 3192 823 9355 8022 826 27255 6092 4902 1641 9260 284656 80031 9048 9046 285704 1821 652 3785 3815 3786 79966 83401 4233 3065 25942 3094 1029 595 83439 1017 994 1026 1499 51176 6909 4935 25904 6932 6934 7402 1051 10627 10891 8912 2308 8913 10413 8911 55571 4609 6804 4343 192669 6910 23112 27327 999 26523 192670 1482 27161 57690 246175 6929 9861 6233 64065 3312 7316 7514 5578 10213 7534 81857 5608 6938 5706 5707 5708 5709 1981 207 5700 5701 1020 5702 7529 5704 5705 5682 5683 5621 5684 5685 5686 5717 5718 5719 1432 11047 5713 5714 5690 5691 5692 1024 5693 5694 7311 5695 7314 4790 26986 3458 5687 5688 5600 5689 864 2146 5045 5046 9475 10498 6093 10025 5443 892 27330 10001 3280 5465 8726 1463 29079 55534 5468 5469 3320 1950 5335 25925 1956 7027 1019 9353 6091 896 3978 7029 1796 9037 1869 8970 25937 8331 5921 4297 129563 8337 5620 128312 100288687 9862 8334 6595 8335 201516 6597 2672 503835 5619 2033 6599 8370 1974 6598 1973 2624 55766 342900 678 8968 4602 390245 7913 23135 8341 503627 8342 55211 84441 8347 100033411 8348 54766 94239 285051 8345 79670 3013 284355 23318 3570 8340 132243 2313 10361 390748 688 8338 5927 359787 255626 10605 6256 124512 6774 3021 57379 6732 653604 3018 151871 3017 85236 3014 6886 6688 8349 5914 474382 1053 6456 1050 54145 861 865 54815 1441 6907 8648 7004 27092 79718 7003 84246 9612 23019 8841 9611 23493 9495 1212 9443 9441 10369 10368 7471 9442 59283 5346 5105 9440 51586 23462 10398 9439 10109 10552 10093 10092 10095 10094 10097 51592 10096 9464 9219 9477 4209 112950 57472 80205 1749 3952 85441 96764 7942 29883 57492 8128 6514 2626 7903 9282 DEFECTIVE MAN1B1 CAUSES MRT15%REACTOME DATABASE ID RELEASE 95%4793950 Defective MAN1B1 causes MRT15 11253 SIGNALING BY EGFR%REACTOME%R-HSA-177929.6 Signaling by EGFR 8874 6456 8038 6455 2060 6457 10254 8027 6868 5295 6464 81610 5290 26018 6233 55824 84985 5829 7316 6714 1950 5335 867 1956 9146 1445 5782 374 10253 5781 4893 14 998 2549 7311 7314 29924 7039 58513 10252 685 5774 5796 255324 2069 1839 102 6654 222584 30011 3265 GSD IV%REACTOME DATABASE ID RELEASE 95%3878781 GSD IV 8908 2998 2632 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%R-HSA-113510.5 E2F mediated regulation of DNA replication 23649 5422 5557 5558 5515 7027 5516 5518 891 983 28227 84515 5000 5001 7029 1869 5925 23595 23594 5519 4998 4999 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME%R-HSA-383280.3 Nuclear Receptor transcription pathway 5915 5914 5467 5916 5468 5469 2063 6097 5241 6257 7181 7421 7182 6096 126382 6095 2099 9975 2104 7068 2103 7067 7376 2101 9612 3164 9611 7025 4929 3172 2516 9572 5465 29959 3174 367 6256 8431 2100 7101 6258 RIBAVIRIN ADME%REACTOME%R-HSA-9755088.3 Ribavirin ADME 132 22978 100 64078 4831 2030 9153 3704 55315 4830 4860 SYNTHESIS OF PG%REACTOME%R-HSA-1483148.4 Synthesis of PG 201164 9489 23646 122618 5337 5338 114971 8760 BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME%R-HSA-9027307.3 Biosynthesis of maresin-like SPMs 1544 1576 1571 1565 1559 1558 RHOF GTPASE CYCLE%REACTOME%R-HSA-9035034.5 RHOF GTPase cycle 4001 7879 60 87 4650 54509 1730 55240 81839 26049 55971 9590 5295 5296 65124 85360 80115 9497 23344 8776 26092 10160 445582 857 29843 10409 55789 832 1729 23380 4162 120 7112 8773 94134 80728 9743 81624 57584 392 9341 394 DISORDERS OF DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 95%9675151 Disorders of Developmental Biology 2874 3065 84661 25942 11091 814 808 5566 6907 9070 5929 79718 9612 8085 8841 9611 IMPAIRED BRCA2 TRANSLOCATION TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%9709275 Impaired BRCA2 translocation to the nucleus 7979 675 COMPLEX III ASSEMBLY%REACTOME%R-HSA-9865881.2 Complex III assembly 728568 3313 7385 27089 1537 7384 617 7386 440567 7388 3954 54902 150274 7381 4519 90624 29796 440957 55245 57128 10975 84300 2395 790955 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 95%73772 RNA Polymerase I Promoter Escape 474382 54145 54700 6908 51082 7343 9533 11335 5440 5441 4331 1022 25885 2071 2966 2965 2068 5434 5435 64425 5437 79101 2968 2967 10849 404672 902 221830 8970 8331 8337 128312 8334 8335 9014 9015 9013 8370 55766 8968 84172 8341 8342 8347 8348 94239 8345 3013 8340 8338 255626 3021 653604 3018 3017 85236 3014 30834 8349 CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME%R-HSA-177128.5 Conjugation of salicylate with glycine 54988 389396 348158 10249 123876 341392 219970 92292 DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME DATABASE ID RELEASE 95%110357 Displacement of DNA glycosylase by APEX1 4968 4350 6996 4913 8930 23583 328 REGULATION OF HOMOTYPIC CELL-CELL ADHESION%REACTOME DATABASE ID RELEASE 95%9759476 Regulation of Homotypic Cell-Cell Adhesion 23478 60559 2146 5045 28972 5046 90701 5928 1785 283106 9159 5931 27085 8726 288 1488 1487 29954 5925 8970 3728 8331 8337 128312 10585 8334 9314 8335 6597 8370 55766 8968 54971 8341 5594 8342 5595 8347 28513 2294 7764 8348 117581 94239 80149 56978 8345 3013 9839 8728 6663 8340 1495 64403 8338 27319 255626 80332 1006 1500 1508 3021 3224 3609 653604 3018 6615 3017 1009 85236 3014 8349 7841 474382 7088 2060 54145 3065 1650 23028 100128731 1499 6185 6935 6184 23193 8289 58505 821 5589 746 1603 3703 4609 4343 192669 23112 27327 387893 999 26523 6591 4613 3066 116092 192670 27161 3170 7020 94234 57690 23396 93986 9861 6929 55810 23512 6233 687 79872 7750 348262 10009 7316 6714 10213 9743 4193 5706 6938 5707 5708 7414 5709 54737 7291 5700 5701 5702 1520 5704 5705 5682 5683 5684 5685 5686 10399 5717 1514 5718 5719 1460 11047 6667 5315 5713 1459 5714 5690 5691 1457 5692 5693 5694 7311 7979 5695 7490 7314 60436 5687 11171 5688 5689 23411 26508 51129 9789 REGULATION OF RUNX2 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 95%8939902 Regulation of RUNX2 expression and activity 59269 579 865 11059 10891 6772 650 57154 133522 9861 6233 9978 2932 7316 10213 5706 5707 5708 5709 7291 5700 5701 5702 5704 2099 6502 5705 5682 1749 5683 5684 5685 2908 5686 2101 5717 5718 5719 4488 1750 11047 5713 5714 5690 5691 5692 10273 5693 5694 7311 7979 5695 7314 8454 5687 5688 5689 6500 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 95%162791 Attachment of GPI anchor to uPAR 8733 10026 128869 51604 5329 94005 80055 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA1 BINDING FUNCTION%REACTOME%R-HSA-9704331.4 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 7486 116028 472 10635 672 675 83990 7516 10111 5932 7979 4361 7156 5890 9156 5892 4683 580 10524 641 1763 79728 5888 80010 5889 METHYLATION%REACTOME%R-HSA-156581.6 Methylation 1544 27430 191 7172 1312 57412 4144 4552 51504 4143 4837 4548 9446 29104 DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-212676.5 Dopamine Neurotransmitter Release Cycle 6571 55327 8541 8497 8499 320 6844 22999 8500 10497 64130 10815 8825 5864 6853 6616 6857 8224 6854 9256 8573 6804 GENE EXPRESSION (TRANSCRIPTION)%REACTOME%R-HSA-74160.9 Gene expression (Transcription) 5915 5916 146713 143686 84661 341359 3977 11091 63970 349075 2660 163049 1327 163051 4839 5928 5929 163050 654254 900 901 51755 340252 1329 905 30832 65243 285676 4850 1340 79891 3516 4848 2669 1337 4849 79898 5931 5933 5934 1339 4605 23619 1351 65018 1350 9070 100287226 1349 79885 1347 388536 1346 1345 55215 10308 124411 10781 10780 4852 10782 65251 1108 162966 162967 162963 1121 100289635 22974 388569 83933 388566 388567 4869 5970 388561 3549 284309 10769 125965 284307 284306 400720 58500 10520 4878 10765 58508 3562 3559 3558 1378 147741 27166 253639 10971 5978 5979 284370 115509 283 90233 29117 4298 6830 1392 57677 27125 3329 55840 4300 57678 10018 3569 85403 1386 55677 79230 339327 339559 146434 26053 124446 353274 6601 6603 6602 6605 158431 6604 57209 91584 7710 57693 387032 613227 27153 27154 57459 133383 7700 4435 4436 219749 10370 6872 5300 6874 6873 220992 995 51003 5442 5775 7712 442319 7711 79813 79818 10135 4208 10138 266743 6880 6883 4221 6882 6884 148254 4697 51499 7341 7022 55615 79047 6875 7021 6878 83741 5305 51741 8812 6877 7329 339488 6879 7020 5308 284252 90827 7728 2290 7323 23429 7743 148266 148268 84962 80818 9978 2289 342926 23660 56950 6921 55869 6923 7733 54778 11200 79837 5440 7738 8732 6648 5441 9915 4331 23439 8731 730087 1022 7752 7994 2071 6662 2966 6829 7753 2064 2965 2063 2963 441234 2962 54541 2068 5434 55634 5435 51276 5436 353088 5437 7745 5438 56729 5439 5325 6657 2968 7988 2967 7748 404672 5430 136051 5431 138474 5432 10127 5433 7761 902 7760 91975 7762 8851 114026 3164 339500 4004 4488 1460 100129543 7755 4005 1459 5579 7757 55888 1457 7770 8861 219578 7771 7532 5111 7531 7773 7533 8621 90874 162972 23410 161882 148213 23411 3174 148203 51058 196528 148206 7525 5588 7767 55659 7766 7769 55657 7768 6696 5366 730291 126231 55663 579 55422 8626 6446 10794 60 10793 10795 7539 5371 7552 7551 9975 285267 9734 285268 7556 581 255403 79862 9968 9969 7549 57615 90649 100131827 7561 129685 7157 7562 7565 122809 7567 7566 4292 355 356 7559 9739 8409 6241 94115 7571 5395 7574 9997 7576 29959 51412 7568 80196 54925 8431 144233 7582 57510 7101 29102 25 7587 6498 7586 11168 6497 6258 253260 7581 84108 9757 8427 7978 7594 7596 9534 8445 7592 126382 142 84333 199777 53615 9540 7122 4091 23368 4094 85456 2908 197320 84124 54715 5196 9794 9310 8463 6046 9314 64769 25799 1820 440519 440515 10273 54971 9337 162239 7159 181 9572 51230 90809 54989 152687 55835 10046 8013 79370 8493 7161 170960 57343 57103 125919 147948 147949 9358 170959 26048 55170 80108 90390 80110 221044 83860 9125 6097 342132 285971 7181 7182 6096 6095 1876 144455 1875 1874 26013 282890 344787 9377 8289 92595 55193 10919 27113 80139 168417 2737 5519 1647 332 2736 79175 133746 6722 93474 84265 84527 55703 4929 112495 387893 11128 84765 51728 58484 5515 9330 57154 27297 83667 661 5516 3845 5518 2976 2516 10623 9212 133522 2975 9167 5451 2972 121340 171568 6621 58491 55290 55814 58492 6619 9328 1437 9329 2971 1436 55718 7702 147923 10622 6618 27300 10621 10302 59348 5527 6617 147929 340385 8089 7422 112858 8085 84775 3622 2539 2538 27165 2744 8178 22916 25920 4686 51224 6924 7936 6827 6749 9150 6917 1025 51497 7469 11198 904 28514 182 3172 8454 890 8900 51129 6500 4023 5566 23405 8575 7257 6895 7247 7222 57504 9112 60528 4851 4853 4854 4855 2645 7919 5562 5563 6794 7248 5564 5565 389541 28956 57521 55004 8649 51422 10670 6009 5494 5571 64121 64223 5901 153129 53632 2475 7249 58528 10542 10325 857 3930 7040 55240 23168 79577 80349 123169 9646 3674 3678 6996 54623 84649 2167 11343 3991 54700 23175 5054 9188 29947 51082 55683 55689 729359 123 8535 23054 9869 51535 6045 1107 22976 83746 7343 648 5166 29128 10514 6015 3066 54934 91661 23468 9759 8202 1912 9533 55596 1911 23512 23272 23314 11176 80012 948 57332 200424 1810 84733 51562 26993 7703 5977 6613 8312 8467 23378 2932 29915 79685 6839 79447 29115 80312 605 259282 8110 2821 2494 25885 79595 57325 147646 84148 51105 54737 22822 22823 125893 64425 7270 147658 79101 80335 10849 6871 26039 57104 2145 284058 8800 10499 55729 6760 221830 8819 8932 55617 7069 1387 91272 6667 121536 9014 9015 9013 90853 9370 26147 84172 54790 2074 814 81931 340602 79611 627 26009 9274 7039 9275 2353 9031 1789 1788 1786 7403 3720 10000 8193 2309 112869 143689 51742 10555 5252 3725 30827 100170841 30834 201164 63924 4781 4782 4784 6741 4774 367 4194 4193 4086 4087 4088 4089 9099 5728 64750 4092 8473 4303 7019 64216 64426 8239 86 6881 10474 10526 7874 1643 8850 2625 284119 3054 54514 7528 51616 2099 84967 134353 65123 57508 80789 26173 55726 5452 55756 64859 2648 26512 5781 4287 23248 25896 80237 79035 79664 3630 29101 22936 10445 81556 55656 79871 23379 2593 54973 5594 92105 5595 51808 55174 57117 55197 84524 58490 9984 81608 208 57187 10898 84324 23283 84321 9877 55339 1479 26097 1478 1477 8563 8683 11051 9775 5770 55110 5170 9785 10978 221400 122402 55124 199746 84944 53981 808 54456 84248 11022 91646 2891 4603 10179 113802 8468 9271 56165 136991 8106 51692 815 2904 6714 51213 2903 816 10189 817 22938 818 51529 7321 8881 64682 51585 25906 11065 8697 7324 10393 29945 10284 27338 119504 29882 891 246184 983 996 51434 51593 51433 7486 79228 5982 5883 5884 5983 116028 3364 472 672 84126 1111 83990 144715 83695 5810 51362 10111 5932 7979 4361 6628 7156 9156 5892 4683 11073 23451 580 10524 641 6634 1763 545 6117 6636 5984 5985 6635 6119 84271 5888 6637 6118 80010 80145 4904 10914 10921 11338 29894 4116 6430 7884 6432 6431 22794 6427 6426 9939 6429 10212 6428 8189 65109 23517 9295 10569 7307 2961 2960 2959 2958 2957 3815 2180 22880 60481 6319 4233 3065 25942 1029 595 83439 1017 1026 1499 51176 25904 6932 100506658 6934 168374 5816 6908 29028 1051 10419 284459 10891 90317 155061 10650 2308 10413 121274 1649 55571 4609 54487 4343 284443 192669 6910 23112 155054 27327 90589 2572 26523 147694 2571 192670 1482 27161 80778 57690 246175 6929 9861 147686 6233 147687 90338 3654 100129842 4986 4988 64065 22869 90576 7316 90333 7514 6940 2100 285349 10213 1493 353355 81856 7534 1490 81857 5608 6938 5706 100131980 5707 79788 5708 283337 4512 5709 4513 4514 22835 3683 207 4773 5700 1263 5701 1020 114787 5702 80317 7529 146540 84914 5704 84924 5705 57547 5682 2104 5683 57541 5684 2103 5685 27287 5686 2101 55367 5717 834 5718 835 5719 3676 839 1432 90594 6720 11047 1030 90592 5713 84911 5714 146542 5690 10628 5691 80314 5692 1024 5693 843 5694 604 7311 847 5695 4778 7314 4790 440077 84701 3458 1278 5687 1277 5688 5600 5875 5876 5689 4322 56242 57573 147657 57336 440073 10848 864 57335 317 79109 50943 54205 6750 3486 3484 23327 199704 632 2146 5045 389114 51123 7832 10013 637 84289 639 10014 10498 11105 10250 162655 146198 117608 640 405 4336 6515 406 10025 23309 7862 79869 6772 5443 7621 2177 2176 1081 650 892 51385 171392 7633 148156 3276 665 341947 79943 7626 7625 10001 11335 7627 3280 6790 25946 5465 126375 374900 55762 79973 79733 5457 8726 5458 7638 348327 7652 23774 29079 57711 55534 5467 5468 5469 3320 55778 10224 8738 25925 1956 5241 7027 1021 91875 1019 7421 894 163732 896 221785 374928 898 200845 148103 3064 51343 6502 694 79755 1616 54457 9134 55786 1027 79759 4149 140612 7029 158399 1869 10432 5925 8970 7673 25937 8331 169270 4297 463 8337 128312 79744 9862 8334 6595 8335 6597 619279 2033 6599 8370 6598 2624 55766 30818 8968 728957 57060 4602 94241 7913 84449 8341 117584 8342 84441 8347 7678 8348 117581 94239 8784 8345 3013 7692 7695 7694 8340 5275 7697 7699 8338 163227 255626 163223 6256 79088 3021 84676 653604 28984 3018 84436 3017 84671 8794 85236 3014 8795 8550 6886 54807 6688 8793 8349 8797 5914 163255 474382 23269 1050 59269 54811 54145 861 55900 865 54815 5052 9656 6257 9891 8317 11059 80095 6907 9422 7001 10172 8648 7004 79718 9668 7003 7005 201514 84246 7376 9612 51564 94039 5079 23019 8841 9611 115196 50484 23493 51333 9443 9441 126070 9442 2874 7025 26974 65988 348 23466 5346 25888 5105 9440 728927 23460 51586 23462 10398 9439 10397 10155 286075 126068 374879 127396 2811 2810 51592 55713 10168 9464 114907 84838 26152 26155 163081 9219 374655 7296 9477 7057 112950 8148 57472 7291 57474 83737 91120 7050 7295 169841 83744 163071 390927 147837 1749 7068 8396 7067 1998 1514 204851 1997 1513 84626 80264 1750 29883 1515 26149 63934 57492 163087 79027 144348 7082 9021 3958 2623 60436 84883 4800 4801 4802 2626 90075 3726 2877 84874 84870 80032 113835 93134 199692 163059 23067 9282 28996 92285 92283 256051 TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME%R-HSA-69895.5 Transcriptional activation of cell cycle inhibitor p21 57060 1026 25946 7157 MITOCHONDRIAL PROTEIN DEGRADATION%REACTOME%R-HSA-9837999.2 Mitochondrial protein degradation 56910 8801 5566 522 1327 55173 1329 539 10476 4722 54995 133686 5832 36 2235 8192 10845 27034 292 293 1632 64983 6182 4719 51079 4712 3028 91689 51116 6687 10939 23203 221154 10730 27166 6472 3329 38 622 3158 5019 6770 115209 4976 3033 56652 197257 9377 217 29928 6742 51142 498 51499 27089 1891 4723 211 4967 4731 26519 5162 5163 4191 4508 55699 5160 3419 50 10632 2746 3418 3313 4512 4513 26520 4540 4541 4535 1431 4536 384 7385 1629 1738 27429 10965 7019 4200 509 4695 10440 9361 5096 2271 506 219 PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME%R-HSA-428559.2 Proton-coupled neutral amino acid transporters 153201 206358 PEXOPHAGY%REACTOME%R-HSA-9664873.4 Pexophagy 7316 7311 7314 8878 472 6233 4077 2034 84749 81631 5830 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME DATABASE ID RELEASE 95%1810476 RIP-mediated NFkB activation via ZBP1 8737 8517 4792 7098 4793 28512 81030 3551 4790 5970 4615 28511 11035 4791 1660 1147 148022 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME DATABASE ID RELEASE 95%3301854 Nuclear Pore Complex (NPC) Disassembly 23636 9631 7175 9972 11097 23279 8086 23511 53371 8480 79023 891 79902 10762 983 5903 348995 9883 6396 129401 9133 9688 140609 91754 10783 57122 23225 4927 23165 55746 8021 55706 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME%R-HSA-389957.4 Prefoldin mediated transfer of substrate to CCT TriC 10383 10382 60 7846 84790 10471 5201 5202 84617 908 113457 6950 7203 10574 7280 347733 10576 7277 7278 22948 81027 5203 10693 5204 10694 10575 10381 7411 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME%R-HSA-446388.3 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 7016 5829 9459 29780 55742 3987 87 6251 DEFECTIVE SLC34A2 CAUSES PULMONARY ALVEOLAR MICROLITHIASIS (PALM)%REACTOME%R-HSA-5619045.4 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) 10568 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963640.5 GRB2 events in ERBB2 signaling 2064 1950 1956 9542 10718 145957 3084 685 2069 1839 6654 4893 3265 GSD XV%REACTOME%R-HSA-3814836.4 GSD XV 2992 2997 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%R-HSA-975576.3 N-glycan antennae elongation in the medial trans-Golgi 6480 2683 11320 4247 4249 8703 8704 8702 4124 9486 64377 2525 25834 338596 2530 4122 9334 9331 2517 1081 3972 8128 51046 6484 4248 11282 PI METABOLISM%REACTOME DATABASE ID RELEASE 95%1483255 PI Metabolism 4952 5286 8898 8821 9896 55361 9110 22876 200576 54893 22874 55300 81846 54545 23760 55697 9107 3631 4534 6305 54477 5295 5296 84725 27124 22908 3636 5290 5291 7179 8871 5305 23396 8867 9108 80230 375775 25816 3635 10908 146850 79153 8394 5294 23533 8395 79837 79626 8897 375 5783 57664 51763 126282 133121 5867 66036 5728 59339 59338 5868 8396 5287 5288 388121 377 93492 81544 8503 5297 5298 660 5293 8776 51552 30849 90809 55613 284161 65977 51573 56623 5289 64419 APC TRUNCATION MUTANTS ARE NOT K63 POLYUBIQUITINATED%REACTOME DATABASE ID RELEASE 95%5467333 APC truncation mutants are not K63 polyubiquitinated 324 MALATE-ASPARTATE SHUTTLE%REACTOME%R-HSA-9856872.2 Malate-aspartate shuttle 79751 10165 4190 4191 83733 2806 8402 8604 2805 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%R-HSA-3134963.4 DEx H-box helicases activate type I IFN and inflammatory cytokines production 3665 4790 4791 170506 5970 4615 1660 SHOC2 M1731 MUTANT ABOLISHES MRAS COMPLEX FUNCTION%REACTOME%R-HSA-9726840.2 SHOC2 M1731 mutant abolishes MRAS complex function 673 22808 5894 5500 5501 8036 7529 369 PROTEIN METHYLATION%REACTOME%R-HSA-8876725.5 Protein methylation 1915 79823 6187 1938 808 151194 22944 79091 399818 254013 3312 221143 196483 7415 79609 2109 10196 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 95%159230 Transport of the SLBP Dependant Mature mRNA 23636 9631 7175 9972 11097 23279 8086 23511 10482 53371 8480 79023 79902 10762 5903 22916 4686 7884 1977 348995 9883 6396 129401 9688 57122 23225 10189 4927 23165 55746 8021 55706 DNA DAMAGE BYPASS%REACTOME DATABASE ID RELEASE 95%73893 DNA Damage Bypass 7706 9100 7353 7398 51514 5980 10459 10714 5424 51455 8451 5425 5981 57804 5982 56655 5983 7415 57599 5429 55666 7320 5426 5427 51426 83932 9768 124739 1642 54107 7318 7311 5111 7314 56852 11201 6233 9978 9246 6117 7316 5984 5985 9636 6119 6118 CARDIAC CONDUCTION%REACTOME%R-HSA-5576891.4 Cardiac conduction 478 53822 783 53826 53828 5566 480 1193 6546 481 4842 2281 6547 482 483 3710 486 775 80228 487 488 6324 489 6323 84876 7220 6331 6717 6330 782 6263 490 6262 6332 491 492 6335 493 6261 6334 8850 6326 6328 6327 6786 6329 6543 6336 11280 3708 3709 55800 5350 444 5348 5349 10345 6588 9424 3775 3751 10089 3752 56659 4878 3757 3770 338567 25937 3776 3777 30818 51305 3784 83795 54207 50801 3761 3759 30819 3750 60598 89822 3753 3741 30820 9992 56660 23704 27092 3768 59285 59284 7137 80333 2259 2258 2257 2256 6910 10008 59283 29098 1760 1482 808 8645 23630 815 816 817 818 10142 4880 204851 4881 4882 4311 1066 10699 10768 2626 10060 476 28996 3767 477 9254 FREE FATTY ACID RECEPTORS%REACTOME%R-HSA-444209.3 Free fatty acid receptors 2864 2867 2865 2853 338557 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%R-HSA-1660514.5 Synthesis of PIPs at the Golgi membrane 5297 7179 4952 5298 5286 9896 55361 30849 200576 55300 55697 5288 56623 5289 377 22908 93492 375 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 95%445095 Interaction between L1 and Ankyrins 6708 6710 286 6712 6709 4897 6324 6323 6331 6330 6332 6335 6334 3785 6326 3786 6328 6327 6329 57731 3897 6711 6336 11280 23114 55800 287 288 51332 CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2%REACTOME DATABASE ID RELEASE 95%9634285 Constitutive Signaling by Overexpressed ERBB2 5782 11140 3320 2064 55914 6464 6654 4893 3265 NONCANONICAL ACTIVATION OF NOTCH3%REACTOME%R-HSA-9017802.2 Noncanonical activation of NOTCH3 4904 83464 51107 4854 5663 23385 55851 5664 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%R-HSA-380972.4 Energy dependent regulation of mTOR by LKB1-AMPK 51719 5562 5563 6794 7248 5564 5565 389541 28956 57521 55004 8649 51422 10670 6009 5494 5571 64121 64223 92335 153129 81617 53632 2475 7249 55437 58528 10542 10325 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME%R-HSA-749476.4 RNA Polymerase III Abortive And Retractive Initiation 4782 4784 6741 4774 5434 5435 5437 6908 51082 84265 55703 112495 11128 51728 9330 27297 661 9533 2976 10623 2975 5451 2972 6621 171568 55290 55814 6619 9328 2971 9329 7702 55718 10622 6618 10302 10621 6617 5440 5441 4781 NUCLEOTIDE SALVAGE%REACTOME%R-HSA-8956321.3 Nucleotide salvage 7083 161823 7378 4860 151531 1890 270 271 3251 272 51292 132 100 353 1633 8226 2766 7084 1716 7371 83549 54963 978 TRANSPORT OF SMALL MOLECULES%REACTOME%R-HSA-382551.7 Transport of small molecules 113 554 114 115 10058 6566 91445 107 108 6048 109 9152 682 196883 6557 91319 6559 9843 5244 10956 126969 28234 81031 6546 6569 1836 6584 6547 10568 6578 283652 606495 51167 51700 487 488 489 6717 490 491 492 493 338 6543 118 8766 2778 6540 140679 6529 54716 23428 92745 6511 6533 206358 84889 6509 120103 55089 117247 340024 10991 6506 6505 6507 9056 9057 153201 6520 8501 23446 6541 123096 81539 8140 23657 55117 56301 11254 6512 6539 11136 6519 124935 54407 4363 84061 29801 8714 7991 80736 6528 4738 6579 6582 375 6580 353189 2793 2792 2791 2790 2788 2787 2786 2785 26234 2784 2783 51764 3043 94235 9429 55970 402 6446 54331 59345 84725 6532 1080 2782 5825 204962 57030 10681 291 292 293 55832 10539 154091 155184 65010 3658 81614 144195 1468 80772 55356 55244 4645 160728 159963 22841 79689 284129 10861 57153 66035 28231 55144 83850 284111 79815 6508 6522 3163 2039 55974 7415 5304 152519 7417 54896 7416 55867 7419 6527 125206 11309 245972 6561 245973 6563 563 115111 57835 155066 4151 23507 6574 9114 6576 51606 6534 6568 6567 91749 6581 6583 6538 345274 3077 9550 523 11182 525 57185 526 115286 527 85414 120 58157 85413 119 528 93380 64849 529 115019 23382 8992 6248 146802 51310 48 90423 94033 51458 84230 51228 127124 7036 79901 23545 348938 9356 51382 56262 123606 200010 57127 57488 9498 26266 80131 533 8170 29988 534 57380 56172 53919 535 57282 537 83697 9058 10312 1201 50617 9296 9497 3954 21 808 815 816 817 818 5245 115584 114134 6526 84679 6550 6553 389015 6548 6549 10479 285195 23315 114757 7979 8454 9388 26119 51360 10257 338328 1213 1211 7436 51128 319 81693 255738 51129 6500 10577 91289 5034 4023 8029 160 161 116519 51296 163 51706 2 6564 1497 23491 121260 57552 4018 8435 5894 213 335 336 337 4864 5566 6646 5567 4547 26291 5568 55908 3990 8720 8165 760 64788 1175 1173 762 3949 345 84699 3069 51599 759 55911 3988 51248 4284 7220 7442 360 361 7222 7224 375318 362 7223 363 7226 364 7225 57084 6536 282679 59341 343 7018 79054 366 55283 358 26133 54795 359 89872 8989 55503 4308 162514 255231 57192 80036 56302 51393 6556 57113 29850 54822 140803 90550 538 91689 6687 9512 3934 10939 23203 55486 55013 79568 64078 221154 23443 11331 23169 30968 10730 2030 23568 10367 10057 286097 11194 389812 10999 23456 5573 51000 23457 5575 5576 10349 11046 89845 5577 3933 85320 347734 286256 10347 20 7355 8884 22 376497 23 24 28965 222962 5243 3177 340273 9197 10350 64137 9153 23461 9154 84912 10351 55315 5824 8894 1965 1968 3040 9861 6233 6575 7316 3162 6510 10864 10213 5706 5707 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 215 5713 5714 5690 5691 5692 5693 8504 23344 5694 6560 10723 7311 5695 57468 6558 7314 83733 5687 5688 65125 5689 63982 1187 225 203859 1186 7037 23200 1185 1184 1183 1182 1181 5002 133308 1180 476 79895 57101 23327 477 478 1179 479 5045 150159 5046 5125 51761 53822 7439 53826 51802 53828 22802 219931 286410 9635 338440 57198 480 1193 481 6515 57194 2281 482 483 486 1188 10786 285175 65266 65268 65267 285335 2495 495 496 144453 10110 9914 10079 2512 55107 6263 6262 94015 57130 6261 23678 2040 540 28962 5205 55515 79751 40 41 266675 23400 374868 54831 23120 55129 50636 9311 5350 8402 161003 259232 84239 7809 9376 23250 444 284525 196527 57719 5348 5349 10345 57205 1831 344905 10396 6340 6588 80727 148229 27032 57578 55240 121601 51076 53373 6337 6339 6338 6517 7781 7780 64116 29986 57181 25800 25769 80024 29985 84102 7779 254428 1317 23516 64924 861 169026 27173 55532 7922 283375 57419 11059 27329 9619 64241 64240 23539 7376 9123 9194 10062 133418 19 1071 341 344 29116 346 347 348 23460 9187 551 55343 10559 27248 79139 26154 51009 113235 6005 6521 6400 9990 368 6513 60482 6514 26503 116085 11160 8671 6531 6530 142680 123041 1356 6524 6523 10599 246213 5172 55630 1244 56606 10060 4891 30061 3767 10613 111 1811 112 CD209 (DC-SIGN) SIGNALING%REACTOME DATABASE ID RELEASE 95%5621575 CD209 (DC-SIGN) signaling 5971 2033 3385 5894 3384 4790 5970 9252 5566 5063 5567 5568 4067 5058 2534 30835 4893 1387 3265 5062 IMPAIRED BRCA2 BINDING TO PALB2%REACTOME DATABASE ID RELEASE 95%9709603 Impaired BRCA2 binding to PALB2 7516 10111 5932 4361 7156 5890 9156 5892 4683 580 10524 641 7486 1763 116028 79728 472 5888 10635 672 80010 675 5889 83990 MAPLE SYRUP URINE DISEASE%REACTOME DATABASE ID RELEASE 95%9865114 Maple Syrup Urine Disease 594 152926 1629 1738 593 VIRAL RNP COMPLEXES IN THE HOST CELL NUCLEUS%REACTOME DATABASE ID RELEASE 95%168330 Viral RNP Complexes in the Host Cell Nucleus 3304 G0 AND EARLY G1%REACTOME DATABASE ID RELEASE 95%1538133 G0 and Early G1 3065 7027 91750 993 132660 1017 286826 898 983 1875 55957 1874 5928 9134 4149 7029 1869 4609 5933 5934 5111 4605 990 890 8900 7153 1859 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%R-HSA-198693.4 AKT phosphorylates targets in the nucleus 208 10000 2309 6199 207 3164 4303 2308 LXRS REGULATE GENE EXPRESSION LINKED TO LIPOGENESIS%REACTOME%R-HSA-9029558.2 LXRs regulate gene expression linked to lipogenesis 6319 2194 7376 6256 10062 8204 6257 27329 CRENOLANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702581.2 crenolanib-resistant FLT3 mutants 2322 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381183.5 ATF6 (ATF6-alpha) activates chaperone genes 3309 7184 22926 468 4800 4801 811 1649 4802 G2 M CHECKPOINTS%REACTOME%R-HSA-69481.5 G2 M Checkpoints 51588 993 7465 9088 7157 29086 51720 63967 7334 7336 8970 128312 79184 10971 8370 8341 8342 8347 8290 8348 8345 8340 255626 3018 3017 85236 3014 8349 54145 9656 8317 1017 995 8318 10926 55388 8924 9861 6233 7316 2810 11200 10213 7534 5706 5707 5708 5709 165918 7468 5700 5701 891 5702 7529 983 7158 5704 5705 5682 5683 7486 5684 5982 5685 5883 5686 5884 5983 5717 116028 3364 5718 472 5719 9025 672 11047 84126 51512 1111 83990 5713 144715 5714 5690 83695 5810 5691 5692 10111 5693 5932 5694 7311 7979 5695 7532 4361 7314 7531 7156 4172 9156 7533 4173 4174 5687 84142 4683 4175 11073 5688 4176 9577 580 4171 10524 5689 990 641 9133 1763 84515 545 6117 5000 5984 5001 890 5985 6119 8900 23595 6118 23594 80010 4998 4999 REGULATION OF NPAS4 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%9768777 Regulation of NPAS4 gene transcription 6722 5978 30818 2908 MET ACTIVATES PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 95%8851907 MET activates PI3K AKT signaling 4233 2549 5295 5290 3082 G2 M DNA REPLICATION CHECKPOINT%REACTOME%R-HSA-69478.5 G2 M DNA replication checkpoint 9133 890 8900 7465 891 9088 983 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-HSA-168188.3 Toll Like Receptor TLR6:TLR2 Cascade 6279 6885 7186 7189 79155 7157 6280 7097 7096 7335 10454 64127 929 8945 114609 59307 11213 5970 841 7334 6271 8517 3146 23643 5594 5595 1386 7099 57162 5604 5598 51231 1849 84166 1147 1848 6285 1846 6288 1845 92610 6283 51295 51135 4214 8651 9684 4793 28512 57161 79671 3551 177 4615 121457 246330 5599 28511 3656 257397 23118 1326 5609 466 80216 6416 4208 5601 7867 5602 5606 5519 5515 5516 5518 6233 8767 948 3654 9261 7316 695 5528 4791 5608 2244 2266 2243 9097 23291 11274 1432 10333 4792 10392 7311 6197 7314 6196 351 4790 9252 6195 8454 4205 2353 5600 2002 6500 3725 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME DATABASE ID RELEASE 95%1169091 Activation of NF-kappaB in B cells 4793 3551 6885 10892 84433 9861 4794 6233 5966 7316 10213 8945 5706 5707 5708 5709 5700 5701 5970 5702 5704 5705 5682 23291 5683 5684 5685 5686 5717 5718 5719 11047 5713 5579 5714 5690 5691 5692 8517 4792 5693 5694 7311 7979 5695 7314 4790 8454 5687 5688 5689 8915 6500 1147 MPS VII - SLY SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206292.6 MPS VII - Sly syndrome (Hyaluronan metabolism) 2990 VXPX CARGO-TARGETING TO CILIUM%REACTOME%R-HSA-5620916.4 VxPx cargo-targeting to cilium 8729 5310 5311 55770 117177 50807 23265 60412 378 54536 4218 8766 6010 149371 1262 1260 1258 9727 10640 11336 55763 DEFECTIVE MTR CAUSES HMAG%REACTOME DATABASE ID RELEASE 95%3359469 Defective MTR causes HMAG 4548 4552 INFLUENZA VIRUS INDUCED APOPTOSIS%REACTOME%R-HSA-168277.8 Influenza Virus Induced Apoptosis 7040 293 DEFECTIVE SLC35A1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5619037.3 Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) 10559 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%R-HSA-4641262.6 Disassembly of the destruction complex and recruitment of AXIN to the membrane 4040 1499 4041 89780 1455 1855 5519 8321 7471 1857 1856 5515 7855 5516 5518 857 7479 7478 23401 2535 5525 10023 5526 8312 2932 5527 324 5528 1452 5529 139285 PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-75896.4 Plasmalogen biosynthesis 8443 8540 25979 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME DATABASE ID RELEASE 95%913709 O-linked glycosylation of mucins 84002 8693 55568 442117 9334 374907 11227 9331 11226 374378 51809 64409 56667 84752 140687 9245 114805 2650 168391 192134 63917 51146 146712 117248 51301 2590 26290 50614 10331 57452 79623 10164 10610 6483 6482 6484 6487 6480 256435 27090 93010 10678 2591 143662 79695 118430 79369 4582 4583 4584 4585 4586 200958 727897 29071 10071 94025 140453 4588 4589 283463 56913 394263 2589 MAP2K AND MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 95%5674135 MAP2K and MAPK activation 673 8826 2244 2266 7414 8844 10256 54518 5894 22866 5906 4140 5908 7450 5037 2243 7094 1445 7529 369 283455 54756 84292 408 409 28956 4893 8649 5594 5595 3690 3674 6714 5604 5605 2335 3265 RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME%R-HSA-5362798.2 Release of Hh-Np from the secreting cell 57758 85455 6868 6469 50846 3549 147111 2262 SIGNALING BY PTK6%REACTOME DATABASE ID RELEASE 95%8848021 Signaling by PTK6 595 1017 9844 5879 5770 63916 6233 2034 3084 1398 1793 3091 5829 7316 116985 2909 1950 2064 867 1956 207 1019 898 10657 27043 10656 1027 2908 9564 1796 55620 6725 6421 202559 5921 4893 7311 9542 9021 10718 7314 145957 685 2069 6774 120892 5753 1839 387 10457 3265 LEADING STRAND SYNTHESIS%REACTOME%R-HSA-69109.5 Leading Strand Synthesis 23649 5422 5557 5558 5111 10714 5424 5425 5981 57804 5982 5984 5983 5985 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%R-HSA-1852241.7 Organelle biogenesis and maintenance 5566 139322 129880 149371 6753 1262 1260 27241 123016 55763 79738 8729 5310 5311 166379 55212 55770 117177 403 6300 79969 50807 23265 92482 8195 84747 60412 378 84100 54536 2847 6102 8766 582 583 54585 585 27031 192668 9727 10640 11336 4899 5577 1386 6604 516 10651 56652 11232 54927 5442 5563 6742 4208 5564 10891 5565 498 51422 5571 211 9738 53632 9662 7840 11064 22994 4508 22995 4509 7283 10733 6648 80321 203068 55722 1454 1453 10632 55125 3418 3313 9814 11190 115106 79441 95681 1069 3842 54801 10142 9702 10540 5108 11116 4751 55142 2101 22897 6950 7203 54930 9551 5116 79959 1432 80184 93323 9556 23354 22981 8481 80254 121441 55755 10806 7532 10121 7531 55559 8636 11258 7019 84131 64216 4957 5600 10694 23410 509 10575 506 9742 513 54205 23322 514 55081 515 347240 55764 79659 22832 57787 10383 57545 8100 517 10382 26005 51098 261734 518 79600 79809 26123 10013 51134 26160 6608 51259 54806 11127 84833 4735 57728 84902 7846 4867 10498 521 57539 522 132320 9657 54903 91147 146057 27077 85302 79867 27109 539 10476 10576 7277 22948 57576 5465 6010 79598 1258 3054 23408 2551 440574 79135 23082 10989 125988 3320 5469 55735 84303 4580 7978 84808 8834 8655 25813 23332 9572 22919 5048 55835 6256 56623 5147 200894 54820 80776 22920 1781 1778 6907 8648 9793 79718 8841 9371 9611 23054 51106 140735 808 5518 133522 23059 28981 3797 150737 51668 55112 11020 57560 56912 6991 23409 64792 92104 83657 200132 83658 26146 89891 112752 255758 2746 51626 4209 90410 79989 80173 9321 2747 983 80205 5347 23373 4218 85441 10499 96764 64784 200186 1387 814 55902 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-HSA-77075.4 RNA Pol II CTD phosphorylation and interaction with CE 2071 2966 6829 2965 2963 2962 2068 5434 5435 5436 5437 5438 5439 2968 2967 404672 5430 5431 5432 5433 902 5440 8732 5441 4331 8731 1022 RRNA PROCESSING%REACTOME%R-HSA-72312.5 rRNA processing 4839 55720 5394 28987 8780 4809 54881 26168 81875 79159 51388 90459 8568 55759 705 79707 57418 23246 23481 26354 55131 81887 84946 10438 55781 117246 83732 10969 10200 3028 54931 23517 9692 60528 6230 6210 6231 6234 6235 6191 2197 6193 6192 6194 51065 140032 6205 6227 6204 6207 6229 6206 6228 6209 6208 6188 6187 6223 6201 6189 6222 6203 6224 6202 6218 6217 3921 79897 11102 54913 10799 6233 10557 11340 23404 51504 10556 54512 6175 5393 55505 23016 54433 1454 1453 55651 51010 51013 118460 1736 22894 56915 7311 10171 79050 84916 23160 10813 27042 55127 54555 84128 51202 8602 92856 11103 65083 9277 25879 9790 51096 55813 5822 22803 27292 56902 2091 115939 25926 114049 27340 10436 27341 57647 55623 55226 88745 10199 9136 22984 57050 55272 51077 10607 11056 9724 84135 134430 51118 10885 10528 6152 6155 6154 6157 9349 6156 6159 6158 23521 51121 11224 6164 200916 6166 6122 6165 6124 6168 6123 6167 6169 6125 116832 25873 6160 6161 140801 4736 6130 6133 9045 6232 6132 6176 6135 6134 27043 6137 6136 6171 6170 6173 6128 6129 4691 6142 6141 6144 6143 6146 6147 6181 6139 6138 9188 22868 285367 26995 387338 55178 130916 51001 79922 29960 81554 51335 84881 51106 51602 REPRODUCTION%REACTOME%R-HSA-1474165.7 Reproduction 7784 49 157855 22917 100129669 257062 117144 284359 5016 4001 639 57828 8747 8748 84329 57829 347732 126123 2515 117155 79820 113177 4292 2683 1019 64321 8970 8331 5460 8337 8243 9126 128312 8334 8335 10735 8370 6677 55766 5885 8968 10274 652 8341 8342 8347 8290 8348 94239 8345 26277 3013 25913 8340 7013 65057 7014 8338 255626 54386 3021 653604 3018 3017 85236 3014 10630 3306 8349 474382 54145 1017 7022 7329 8468 10734 6847 27030 7852 4438 4439 10388 84057 56979 23626 9985 9139 342977 11144 23345 23224 644186 23353 25777 27127 93426 256126 472 56158 29893 672 79923 675 50511 8320 63979 10111 5932 54790 4361 7156 55732 4683 641 545 6117 6119 5888 6118 928 5889 7783 378807 11085 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%R-HSA-429914.4 Deadenylation-dependent mRNA decay 9125 6499 25904 57819 9775 23019 4850 1975 55571 4848 4849 1977 246175 23658 11340 23404 54512 51690 55802 11157 25804 5393 23016 5073 51010 167227 57472 1981 51013 9924 255967 118460 85456 22894 56915 29883 1974 1973 9337 219988 23644 26986 1656 27258 54464 196513 27257 79670 80349 80153 23318 10605 9652 10767 115024 28960 MYD88 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 95%5602498 MyD88 deficiency (TLR2 4) 10333 2244 6271 2266 114609 3146 23643 6280 7097 7096 4615 2243 7099 948 6279 695 929 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%R-HSA-209543.3 p75NTR recruits signalling complexes 4803 7311 5584 7314 3551 4804 8878 4615 6233 8767 3654 7316 7189 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%2197563 NOTCH2 intracellular domain regulates transcription 10046 2033 4853 3002 2208 388585 9794 84441 3280 3516 55534 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%R-HSA-450282.3 MAPK targets Nuclear events mediated by MAP kinases 5599 466 4208 5601 5602 1432 5519 5515 6197 5516 6196 5518 5594 5595 9252 6195 1386 4205 2353 9261 5600 2002 5528 5598 51231 3725 1849 1848 1846 1845 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%R-HSA-2206307.5 MPS IIIA - Sanfilippo syndrome A 6448 POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250913.6 Positive epigenetic regulation of rRNA expression 474382 57459 3065 54145 54815 60 5928 6908 9188 10919 51082 1107 5931 10514 3066 9533 11335 8850 8467 2932 5440 5441 1108 9219 25885 57504 9112 5434 5435 64425 5437 7270 79101 10849 53615 221830 8970 8331 2648 8337 128312 8334 8335 9014 9015 2033 9013 8370 55766 8968 84172 2074 7913 8341 8342 8347 8348 94239 8345 3013 9031 23451 8340 8338 255626 3021 653604 3018 3017 85236 3014 30834 8349 POSTMITOTIC NUCLEAR PORE COMPLEX (NPC) REFORMATION%REACTOME DATABASE ID RELEASE 95%9615933 Postmitotic nuclear pore complex (NPC) reformation 23636 7341 9631 23279 7329 23511 53371 5901 79023 1104 79902 3842 3837 348995 9883 6396 129401 25909 9688 5905 57122 23165 55746 55706 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME DATABASE ID RELEASE 95%174414 Processive synthesis on the C-strand of the telomere 5111 10714 5424 26277 5425 57804 25913 3978 7013 641 7486 65057 1763 7014 2237 6117 54386 6119 6118 MLL4 AND MLL3 COMPLEXES REGULATE EXPRESSION OF PPARG TARGET GENES IN ADIPOGENESIS AND HEPATIC STEATOSIS%REACTOME DATABASE ID RELEASE 95%9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis 84661 11091 5929 10025 9968 9969 892 10001 9070 25 29079 5469 63924 58508 5925 8970 8331 8337 128312 9862 8334 8335 2033 8370 55766 8968 8341 8342 57678 8347 8348 94239 8345 3013 8340 8338 255626 2180 6256 3021 653604 3018 3017 85236 3014 8349 90390 60481 474382 84649 6319 1050 54145 2167 11343 6907 3991 51003 8648 79718 23175 84246 9612 10891 8841 9611 729359 123 23054 9443 22976 2874 9442 5166 5346 9440 8202 133522 948 9439 84962 79447 8085 2494 9477 22822 1020 57104 8800 10499 7069 1387 9370 1024 79611 23411 7403 51129 10555 4023 9282 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%R-HSA-193775.3 Synthesis of bile acids and bile salts via 24-hydroxycholesterol 10858 1646 1645 6718 1109 1582 10998 11001 8644 80270 23600 51302 1593 REGULATION OF NECROPTOTIC CELL DEATH%REACTOME DATABASE ID RELEASE 95%5675482 Regulation of necroptotic cell death 8797 6386 11140 3320 8737 329 83737 841 11035 330 5071 7186 10015 8473 10273 355 7311 356 8717 7314 10211 6233 8743 8772 57162 7332 7316 331 197259 2319 8795 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME DATABASE ID RELEASE 95%179409 APC-Cdc20 mediated degradation of Nek2A 8881 64682 25906 11065 8697 7324 10393 29945 27338 119504 29882 246184 996 51434 51433 4751 9184 991 7311 7314 6233 7316 4085 51529 7321 701 PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME DATABASE ID RELEASE 95%8849468 PTK6 Regulates Proteins Involved in RNA Processing 10657 10656 5753 6421 202559 GLUTATHIONE CONJUGATION%REACTOME%R-HSA-156590.4 Glutathione conjugation 2678 124975 2687 79017 2730 2950 2686 494143 55748 2954 26873 2729 4257 2937 4258 4259 79094 373156 2939 2948 27306 2944 2941 2949 2947 2938 2946 2940 2953 2952 221357 119391 2098 653689 10327 9446 LDL CLEARANCE%REACTOME DATABASE ID RELEASE 95%8964038 LDL clearance 163 23491 57552 8435 4864 6646 338 26119 1213 1211 1175 1173 3949 255738 51599 10577 3988 160 161 FRUCTOSE BIOSYNTHESIS%REACTOME%R-HSA-5652227.6 Fructose biosynthesis 231 6652 DEFECTIVE GGT1 IN AFLATOXIN DETOXIFICATION CAUSES GLUTH%REACTOME DATABASE ID RELEASE 95%9035968 Defective GGT1 in aflatoxin detoxification causes GLUTH 2678 MECHANICAL LOAD ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN OSTEOCYTES%REACTOME DATABASE ID RELEASE 95%9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes 6696 5027 781 782 783 784 207 2697 3690 3339 3685 59284 9780 3678 3688 24145 8912 SCN4%REACTOME%R-HSA-3282872.4 SCN4 92579 SIGNALING BY MAPK MUTANTS%REACTOME DATABASE ID RELEASE 95%9652817 Signaling by MAPK mutants 11221 80824 5594 1852 1849 1850 1848 UBIQUINOL BIOSYNTHESIS%REACTOME%R-HSA-2142789.6 Ubiquinol biosynthesis 56910 27235 51805 57017 57107 56997 23590 10229 84842 79934 51004 51117 84274 DEFECTIVE SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME%R-HSA-5659735.4 Defective SLC6A19 causes Hartnup disorder (HND) 340024 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME DATABASE ID RELEASE 95%2730905 Role of LAT2 NTAL LAB on calcium mobilization 9846 4067 5295 5296 2534 6850 6654 7462 5290 5291 5170 BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME DATABASE ID RELEASE 95%9018679 Biosynthesis of EPA-derived SPMs 246 4048 5743 240 3248 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%73817 Purine ribonucleoside monophosphate biosynthesis 3615 3614 122622 5471 5198 10606 158 159 8833 2618 471 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 95%449147 Signaling by Interleukins 3977 1435 4312 4843 4313 2208 1399 3636 1398 9655 79792 1154 3552 5743 3553 5970 6616 841 5780 5782 5784 8809 54472 5778 8807 7850 7334 3562 4215 3559 84867 26095 3558 11141 3557 3565 27178 10068 5771 3596 26469 25930 3146 3569 1386 3606 57162 5598 7409 51231 1849 1848 1846 1845 8651 3551 8878 4615 5599 5775 4208 6655 821 6382 3684 8767 2357 9978 3091 4067 3635 3689 7006 6175 9987 6648 9049 6775 9446 4507 375 3716 3936 654483 3313 4318 5478 6647 5898 4088 6845 6888 7297 4282 5055 9097 3595 240 3594 6657 3593 3592 1072 246 27250 302 1265 3586 5721 4478 6950 2939 5306 829 11274 4792 10392 5293 6197 6196 9252 6195 4205 7525 6885 4170 7186 7189 7157 79155 7133 356 2919 50616 2625 941 942 10454 64127 5783 2185 5781 8503 998 8517 8660 5594 5595 54014 1147 6654 6351 6352 6356 6097 6348 6347 3662 6349 2247 6095 6364 6935 6363 6367 1230 5295 3688 5296 6464 5519 332 5290 5291 2920 9846 3576 3667 5515 5516 5518 58480 3627 5451 1437 1436 1234 5528 7422 4791 3717 3561 3929 3587 6776 23291 5724 4692 10538 3598 3597 2534 6850 6624 79923 3055 9180 149233 3932 133396 4985 200081 3082 51561 6809 3566 27189 3976 1489 5008 58985 132014 6627 3574 3572 1271 7979 1270 3575 351 3590 3589 4314 8454 3588 85480 10148 64109 23529 163702 55540 2162 29949 116379 53833 53832 55801 6500 282617 282618 5034 11009 282616 3718 3554 246778 9466 50604 6773 9244 386653 7076 3603 29760 1440 64806 301 5908 5566 6810 6813 759 5657 729230 5292 8835 7335 920 3181 8945 3185 2335 1901 1511 59307 11213 3911 3934 5896 5897 146433 3383 595 1026 2308 7412 4609 6804 7132 9861 6233 3654 9261 4988 3312 7316 3162 5803 10213 7534 5608 5062 5706 5707 5708 5709 207 5700 5701 5702 5704 5705 9235 5682 5683 5684 5685 5686 5717 5718 834 5719 1432 11047 5713 5714 5690 5691 6844 5692 5693 5694 604 7311 2889 5695 7314 4790 3458 1278 5687 5688 5600 5689 836 90865 7040 9173 4001 7431 8808 27179 27177 56300 6772 5443 26525 84639 29110 7184 3563 59067 3560 3581 84868 2885 3578 1439 50615 1438 3568 3601 3567 3600 6777 3965 3320 867 4582 7124 6597 1052 8968 6778 3570 6774 5604 653604 84166 6285 6288 92610 6283 51135 9684 4793 28512 57161 1441 79671 3687 177 121457 246330 28511 3656 257397 23118 1326 5609 466 80216 6416 5601 7867 5602 5606 84818 23765 948 3605 112744 7291 596 598 5777 9021 2353 4128 3726 2002 2309 3725 JOSEPHIN DOMAIN DUBS%REACTOME DATABASE ID RELEASE 95%5689877 Josephin domain DUBs 7316 7311 7415 7314 5886 9929 6233 4287 5887 5071 92552 126119 SIGNALING BY WNT%REACTOME DATABASE ID RELEASE 95%195721 Signaling by WNT 163 166 84661 51699 9559 55737 11091 79971 50999 5929 1175 1173 1455 3710 5593 9070 3708 3709 8945 4040 22943 7483 4041 89780 6423 11197 6422 90780 57680 27121 79412 9580 83999 56998 283149 27123 83595 50964 64321 25776 26108 55553 6658 607 6736 5145 6659 4772 7481 5534 5592 5158 5148 7976 7855 51701 8322 5330 5331 5530 8323 5532 2780 23236 2535 2775 7088 7089 3065 7091 83439 1499 51176 6932 6934 5879 4221 4609 4343 192669 23112 27327 26523 192670 27161 57690 9861 81847 6233 7473 9736 7479 7478 9978 51339 59349 23072 440193 7316 7514 8658 5578 10213 7534 8313 1454 5706 5707 6662 5708 5709 59352 55366 207 343637 5700 5701 340419 54894 5702 8549 6657 284654 84133 5704 5705 64750 5682 5683 5684 5685 5686 5717 5718 2793 5719 2792 2791 1460 11047 2790 5881 5582 5713 1459 5714 5579 5690 2788 5691 1457 5692 2787 5693 2786 5694 7311 2785 5695 7314 2784 2783 857 51764 5687 5688 5689 23401 10023 331 864 94235 9101 55970 8452 6885 54331 54764 59345 80351 409 64840 2782 10681 8295 8724 5880 8607 8395 57216 50855 9757 1488 1487 8970 8331 1855 8337 128312 8334 8335 6597 7480 2033 8370 1857 55766 1856 8968 8341 8342 8347 79577 8348 8290 94239 7090 23513 8345 3013 123169 8340 8338 208 255626 3021 653604 387 3018 3017 85236 3014 80326 8349 474382 54145 23002 5216 7015 144165 5519 51384 1212 4920 8321 8325 7471 81029 4919 6259 5515 57154 5516 808 5518 5525 5526 8312 7472 815 7475 2932 5527 7477 5528 324 1452 5529 7476 139285 7482 1387 7484 54361 7979 8454 1213 10524 1211 84870 7474 8324 6500 160 161 DEFECTIVE B3GALT6 CAUSES EDSP2 AND SEMDJL1%REACTOME DATABASE ID RELEASE 95%4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 6382 2239 2719 2817 375790 1462 3339 63827 1634 6383 126792 221914 633 9672 1464 10082 6385 1463 10675 2262 REGULATION OF ENDOGENOUS RETROELEMENTS BY PIWI-INTERACTING RNAS (PIRNAS)%REACTOME DATABASE ID RELEASE 95%9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 474382 57459 3065 54145 54815 60 5928 8289 29947 1107 5931 3066 5977 605 8110 1108 9219 57504 9112 147646 53615 26039 6760 8970 8331 8337 128312 8334 6595 8335 6597 6599 8370 90853 57492 6598 55766 8968 8341 8342 8347 8348 94239 9274 8345 9275 3013 8340 1788 8338 6601 255626 8193 6603 6602 143689 6605 3021 653604 6604 3018 3017 85236 3014 8349 86 TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME%R-HSA-1299287.3 Tandem pore domain halothane-inhibited K+ channel (THIK) 56659 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME%R-HSA-381033.4 ATF6 (ATF6-alpha) activates chaperones 8720 3309 7184 22926 468 4800 4801 51360 811 1649 4802 RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME%R-HSA-9948299.2 Ribosome-associated quality control 6152 6155 6154 6157 9349 6156 6159 6158 23521 51121 11224 6164 200916 6166 6122 6165 6124 6168 6123 6167 6169 6125 116832 25873 6160 6161 140801 4736 53918 6130 6133 9045 6230 6232 6132 6210 6176 6231 6135 6234 6134 6235 6137 6191 6136 2197 6059 7415 6193 6171 6192 6170 6194 6173 6128 51065 6129 140032 55666 6142 6205 6227 6141 6144 6204 6143 6207 6229 6146 6147 6206 6228 6181 6139 6138 6209 6208 6188 6187 6223 6201 6189 6222 6203 6224 6202 6218 6217 3921 84164 10973 8453 9861 7323 6233 7322 26046 9978 7316 6921 6923 10213 6175 7321 22980 5706 5707 5708 23008 5709 7353 5700 55139 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 90850 5690 5691 5692 5693 5694 9147 7311 7979 5695 7314 5687 5688 5689 INTERLEUKIN-27 SIGNALING%REACTOME%R-HSA-9020956.3 Interleukin-27 signaling 3716 6774 3572 6772 821 7297 246778 9466 10148 3717 9244 DEFECTIVE DPM3 CAUSES CDG-1O%REACTOME DATABASE ID RELEASE 95%4719360 Defective DPM3 causes CDG-1o 8813 54344 8818 ORGANIC CATION TRANSPORT%REACTOME DATABASE ID RELEASE 95%549127 Organic cation transport 55356 6580 55244 861 6581 6583 8170 115286 6584 85413 5002 6248 146802 6582 6563 SARS-COV-1-HOST INTERACTIONS%REACTOME%R-HSA-9692914.3 SARS-CoV-1-host interactions 7706 861 3656 7187 64398 7189 5170 3661 340061 29108 29110 6441 7329 5479 2280 6233 57506 80143 11123 9641 7316 9111 2810 9868 10465 26007 7534 5706 5478 4088 4089 83737 4869 5970 7529 64135 5094 3837 6230 6232 11035 6210 6231 6234 114548 6235 6191 2197 6193 6192 834 6194 51065 140032 598 6205 6227 6667 6204 10971 6207 3838 6229 2033 6206 6228 1915 4792 6209 6208 6188 7311 7532 23586 6187 6223 7314 6201 7531 4790 857 6189 7533 6222 6203 6224 6202 3178 6218 6217 3921 684 51284 9360 PROTEASOME ASSEMBLY%REACTOME%R-HSA-9907900.1 Proteasome assembly 143471 389362 56984 51371 80227 122706 5710 10197 5711 8624 5715 5716 84262 9491 23198 9861 10213 5706 5707 5708 5709 5696 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5721 5717 5718 5719 5698 5720 5699 11047 5713 5714 5690 5691 5692 5693 5694 7979 5695 5687 5688 5689 SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 95%1295596 Spry regulation of FGF signaling 673 867 7311 5515 7314 5516 5594 5518 5595 6233 7316 10253 8569 5781 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%R-HSA-2173782.3 Binding and Uptake of Ligands by Scavenger Receptors 4035 3320 3512 213 259 3263 335 5052 6678 3250 3240 811 9332 23166 284297 4481 922 286133 8685 2495 1284 1282 55576 1281 8542 7184 117156 10525 2512 348 8578 81035 10808 78989 3146 3040 5648 6280 3043 338 1278 948 1277 6288 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-375276.10 Peptide ligand-binding receptors 553 554 594857 64106 301 129521 128674 3827 2862 60675 4922 4923 8620 680 84634 3060 5367 23620 3062 3061 10316 6753 4828 4829 5473 84539 729230 27202 719 2847 4852 727 728 1235 2357 4986 4988 3579 3577 6750 718 183 5443 2919 4158 5196 3640 51083 4987 3792 6288 2587 4886 6351 4887 6352 4889 58191 122042 6354 6357 6356 2359 6348 6347 6349 2826 10850 6361 9034 6364 6363 6366 6367 1230 6751 6360 5540 6752 2833 5539 643 10663 116512 6373 6372 6755 6374 10022 6376 6754 6370 8811 1238 339403 2921 57007 2920 1237 5697 1236 256933 1233 7504 3576 1232 51289 56477 4142 8862 4283 6387 51052 4157 6346 10803 51554 9718 4161 10563 3627 4160 5368 4159 117579 5173 7852 1234 5020 4295 7200 6019 5021 1524 7201 1909 8484 1908 186 187 2834 2832 2831 1907 1906 283869 84432 57486 6375 2852 551 2693 1910 50865 84109 1889 10874 2861 9283 10887 59350 10886 1325 257313 2532 387129 2358 4985 2922 2147 6870 6863 2925 6865 6846 6866 6869 185 351 623 624 56923 2151 2150 2149 2829 5179 885 886 887 2837 347148 9002 5660 3814 10911 552 INTERLEUKIN-18 SIGNALING%REACTOME DATABASE ID RELEASE 95%9012546 Interleukin-18 signaling 3606 3596 8809 8807 240 3565 27178 10068 SIGNALING BY RAS GAP MUTANTS%REACTOME DATABASE ID RELEASE 95%9753510 Signaling by RAS GAP mutants 3845 4893 3265 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME DATABASE ID RELEASE 95%114452 Activation of BH3-only proteins 5366 572 7027 8626 637 207 5599 7529 8655 23368 7029 1869 27113 596 5533 10971 7157 5534 140735 7532 7159 7531 10018 7533 208 7161 10000 2810 90427 7534 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 95%420029 Tight junction interactions 5584 7122 50848 56288 9069 23562 64398 9080 53842 137075 51208 5010 24146 9073 84612 9071 9076 149461 9074 9075 26285 10207 1366 1365 1364 49861 84552 10686 92359 50855 SORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669936.2 Sorafenib-resistant KIT mutants 3815 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 95%73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 2071 2966 2965 83860 2963 2962 8148 2068 5434 6872 5435 5436 51616 6874 5437 6873 5438 5439 2968 2967 404672 6881 5430 5431 138474 54457 5432 5433 6908 902 6880 6883 2961 2960 6882 6884 2959 2958 129685 2957 6875 6878 6877 6879 5440 5441 4331 1022 RHO GTPASE EFFECTORS%REACTOME DATABASE ID RELEASE 95%195258 RHO GTPase Effectors 6279 4628 79784 4629 3984 3985 103910 4637 4627 6280 2316 10971 5300 1499 995 5879 4221 4638 999 5580 367 695 50508 7514 5578 7534 5062 1536 10811 1535 10458 55845 4688 4689 7529 1072 8936 1432 10787 10152 5579 124056 7532 7531 7533 5600 3071 5058 10163 23191 653361 27035 10006 60 9475 6093 1080 64130 7454 7456 10788 348995 6396 5880 57122 147179 25 3895 55746 8826 4690 23279 11113 79023 5063 79902 23433 5903 54908 644150 6232 9928 8655 25909 5585 8379 5586 9183 1027 1063 1062 91010 9184 5590 1060 8970 8331 1855 991 8976 8337 151648 55166 128312 8334 752 8335 1058 79019 998 151246 8370 9735 1857 55766 1856 8968 23332 57591 8341 79003 8342 55055 5594 29941 8347 81565 5595 85415 8348 22919 30849 94239 348235 5048 8345 6242 128239 3013 23421 220134 57082 8340 23380 1495 57405 8338 51143 255626 147841 4085 64105 3021 401541 10403 653604 387 3018 81624 391 3017 5289 388 26999 85236 389 3014 54820 80776 701 8349 54821 474382 378708 286205 1781 54145 23122 1780 23002 79172 1778 23028 81930 55920 84643 114793 29984 3796 10810 5216 5217 9793 91687 57551 79682 5905 1783 5501 3688 83540 80152 2491 5519 57120 332 55143 5170 699 6722 11243 51466 71 3619 114822 140735 5515 4771 11004 3798 5516 808 3799 5518 4660 9212 2017 25936 10398 11130 54763 64946 1742 10109 79980 10726 1729 10552 10093 5525 10092 5526 10095 55839 10094 5527 10097 2810 5528 10096 5500 5529 64837 354 94274 89953 147700 3817 23081 3831 30851 9055 51517 5347 10499 4659 5747 6249 SIGNAL ATTENUATION%REACTOME%R-HSA-74749.5 Signal attenuation 3630 3667 3643 8660 2887 5594 5595 6464 6654 DEFECTIVE AHCY CAUSES HMAHCHD%REACTOME DATABASE ID RELEASE 95%5578997 Defective AHCY causes HMAHCHD 191 DEFECTIVE SLC12A3 CAUSES GITELMAN SYNDROME (GS)%REACTOME%R-HSA-5619087.4 Defective SLC12A3 causes Gitelman syndrome (GS) 6559 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%R-HSA-2559582.4 Senescence-Associated Secretory Phenotype (SASP) 474382 54145 1029 1017 1026 79813 1051 10919 3576 6233 7316 51529 7321 8881 64682 25906 11065 3552 8697 7324 10393 29945 1021 27338 1019 119504 29882 5970 246184 996 51343 51434 51433 1027 27287 8970 8331 8337 128312 8334 1030 8335 8370 1032 55766 1031 3490 8968 7311 6197 8341 7314 6196 5594 8342 4790 5595 8347 3569 6195 8348 94239 8345 2353 3013 8340 8338 255626 6774 890 3021 8900 5598 653604 3725 3018 3017 85236 3014 8349 REGULATION OF CDH11 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%9762293 Regulation of CDH11 gene transcription 27319 26508 3224 3609 6615 2294 56978 6667 9839 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 95%1834941 STING mediated induction of host immune responses 3661 340061 29110 147945 23220 6778 11277 4361 2547 6737 7520 51428 3428 197358 5591 115004 PKR-MEDIATED SIGNALING%REACTOME%R-HSA-9833482.3 PKR-mediated signaling 3305 7706 378708 5611 54920 3551 8894 6772 1965 1660 6622 2176 5519 1968 8575 7157 25820 7341 6895 5610 7329 5515 5516 5518 8877 57506 199990 9246 5525 55120 3312 2189 91442 80233 2175 9636 2188 2187 57697 2178 5608 4690 4869 983 3608 201254 5771 8517 103 3304 51191 6774 3609 1147 3306 DEVELOPMENTAL LINEAGE OF MULTIPOTENT PANCREATIC PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 95%9937080 Developmental Lineage of Multipotent Pancreatic Progenitor Cells 2255 2252 1950 2249 2247 ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME%R-HSA-8963889.5 Assembly of active LPL and LIPC lipase complexes 5045 5046 5125 337 27329 26291 55908 51360 3990 338328 8720 64788 84699 51129 91289 4023 116519 344 CAM PATHWAY%REACTOME DATABASE ID RELEASE 95%111997 CaM pathway 113 114 115 107 108 109 196883 5566 5567 5568 5153 5573 5575 5576 5577 5582 5613 156 3838 5137 10645 26960 84254 814 808 5580 5136 815 5578 816 817 818 111 112 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME DATABASE ID RELEASE 95%111471 Apoptotic factor-mediated response 22900 55075 57099 708 1029 5594 5595 578 581 51074 331 1687 840 842 317 836 54205 56616 79792 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 95%73886 Chromosome Maintenance 55135 5928 5931 8607 23649 5422 5557 5558 4869 10714 5424 5425 57804 5981 3978 1616 546 1060 8970 8331 8337 55166 128312 8334 1058 8335 79019 8370 55766 8341 8342 8347 8290 8348 94239 8345 26277 3013 23421 25913 57082 8340 7013 65057 7014 8338 255626 54386 64105 3021 401541 3018 3017 85236 3014 8349 474382 378708 54145 79172 1017 7015 91687 79682 2237 80152 2491 64946 387103 10856 8467 55839 54069 100134934 5537 5440 55505 5441 11339 54433 55651 79991 51773 54921 5434 5435 5436 23243 5437 5438 5439 55320 5430 80119 5431 5432 7486 55164 5433 5982 1736 55355 55291 5983 63922 80169 201254 79075 51750 5111 641 1763 6117 5984 890 5985 6119 8900 6118 ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME%R-HSA-379398.5 Enzymatic degradation of Dopamine by monoamine oxidase 4128 1312 SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 95%3232118 SUMOylation of transcription factors 7341 7022 9112 7021 51588 8554 7329 1029 10401 7158 6612 6613 6670 3090 4286 668 7157 4193 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME DATABASE ID RELEASE 95%2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 2041 6774 6299 55211 6997 27022 2247 7547 5460 57167 79923 6657 ANDROGEN BIOSYNTHESIS%REACTOME%R-HSA-193048.5 Androgen biosynthesis 3972 3284 3283 1586 3293 5443 51144 6715 79644 6716 1081 SIGNALING BY TGFBR3%REACTOME DATABASE ID RELEASE 95%9839373 Signaling by TGFBR3 5914 6938 83464 51107 7076 7046 7048 10755 4088 7040 4089 2247 7077 408 409 6667 4343 2033 192669 23112 7049 27327 92 26523 4613 192670 27161 57690 3624 3623 6929 6256 6925 4323 4617 4618 4325 5663 4654 7042 23385 4656 83855 55851 5664 3070 REGULATION OF TP53 EXPRESSION%REACTOME DATABASE ID RELEASE 95%6804754 Regulation of TP53 Expression 639 7157 DEFECTS OF PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-HSA-9823587.3 Defects of platelet adhesion to exposed collagen 2811 2812 7450 2815 2814 11093 AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME%R-HSA-211957.3 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 1544 COX REACTIONS%REACTOME%R-HSA-140180.4 COX reactions 5742 PI3K AKT ACTIVATION%REACTOME DATABASE ID RELEASE 95%198203 PI3K AKT activation 3667 4803 5295 8660 5296 387 4914 5290 5291 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-629597.5 Highly calcium permeable nicotinic acetylcholine receptors 8973 1143 1142 1141 1138 1137 1136 1135 1134 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-HSA-5693571.3 Nonhomologous End-Joining (NHEJ) 51588 54145 9656 8924 22976 29086 2547 7520 3981 7518 51720 51567 79840 55775 55183 27343 165918 64421 27434 7468 7158 7334 8970 472 7336 9025 672 128312 79184 8370 10111 8341 4361 8342 8347 8290 8348 5591 8345 84142 4683 9577 580 8340 10524 255626 3018 3017 85236 3014 8349 SUPPRESSION OF AUTOPHAGY%REACTOME%R-HSA-9636569.3 Suppression of autophagy 80824 7879 AGGREPHAGY%REACTOME DATABASE ID RELEASE 95%9646399 Aggrephagy 8100 3320 1781 1780 140735 7311 10013 7314 1778 6233 8655 7335 3297 51143 1068 7316 1783 7415 11315 7334 5116 200894 1080 5071 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME%R-HSA-76071.4 RNA Polymerase III Transcription Initiation From Type 3 Promoter 5434 5435 5437 6908 51082 84265 55703 11128 51728 27297 661 9533 10623 5451 6621 171568 55290 55814 6619 7702 55718 10622 6618 10302 10621 6617 5440 5441 INFECTIOUS DISEASE%REACTOME%R-HSA-5663205.14 Infectious disease 5611 721 5928 905 55763 8729 5931 712 716 719 722 725 1108 23479 4869 5970 6616 6857 10769 7334 10971 5978 3569 10451 7410 51311 10294 7409 2288 57459 3839 2633 402569 10728 3840 3459 3841 3460 23601 3551 6872 6874 6873 5599 51003 5879 2237 6880 6883 6882 6884 2212 945 7341 55615 29108 6875 6878 8812 6877 7329 6879 7322 9978 6921 6923 5869 7428 5440 8732 5878 5441 4331 8731 1022 2071 2966 6829 2965 4318 2963 6993 2962 2068 5434 5435 5436 5437 5438 5439 2968 2967 404672 5430 5431 138474 5432 5433 902 2793 2792 2791 1460 2790 1459 2788 1457 2787 2786 2785 7532 2784 7531 2783 51764 7533 3043 684 11314 7525 94235 55970 60 5371 54331 59345 9968 9969 129685 6238 2782 10681 348995 9883 6396 129401 29959 9688 291 292 57122 293 23225 3836 25 4927 3159 3843 23165 11168 55746 55706 23636 253260 9631 7175 9972 11097 23279 8086 23511 53371 8480 79023 79902 142 10762 8815 5903 53615 6232 8655 1654 2908 1855 998 1857 1856 51143 1147 90390 1781 83860 1780 1778 57551 5905 1783 5501 3688 71 140735 4791 3717 8178 22916 25920 4686 51224 6924 917 7936 6827 6749 9150 6917 1025 51497 2534 7469 4651 6850 3055 4620 11198 3932 904 4641 2214 2621 2147 5627 1213 1211 51128 6500 5034 51284 3718 3554 5336 160 30011 161 6773 2926 163 3615 3614 29760 51185 1312 973 23186 974 335 3454 10280 5566 5133 23476 5567 59272 25855 5568 10800 5926 10362 51317 1175 1173 3069 4627 115361 7318 7317 2634 10533 84313 51028 11267 9871 5119 10951 9632 7335 9641 3665 10427 8945 57504 9112 7448 811 6230 6210 6231 6234 2209 6235 6191 22863 2197 6193 6192 6194 55236 5573 51065 5575 140032 5576 6205 5577 6227 5613 6204 6207 6229 6206 6228 1915 6209 6208 6188 6187 6223 6201 6189 4210 6222 10910 6203 4907 953 6224 957 6202 9051 3178 57674 6218 3480 6217 3921 1839 2923 3326 3107 3106 23352 57521 3134 3133 558 1977 10525 3040 64223 163351 5901 2984 112755 2280 79849 79872 127833 2475 9246 203068 5062 3135 10811 1535 4360 10458 7879 55845 10802 10484 25777 4751 8936 10787 10152 10333 9039 124056 8065 857 79876 3071 63982 51191 203859 10163 80824 23191 2589 7113 6733 476 57101 27035 477 478 10006 53822 7040 53826 55048 53828 89853 1104 51534 9525 137492 338440 27183 480 51271 51160 481 155382 93343 7251 79720 482 483 5902 486 51510 115004 55107 5648 2547 7454 7520 7456 3981 7518 80143 6152 6155 6154 6157 9349 6156 6159 55129 6158 23521 50636 147179 51121 11224 6164 200916 6166 6122 6165 6124 6168 6123 196527 57719 6167 6169 5348 6125 5349 116832 25873 6160 6161 140801 4736 4650 6130 6133 9045 644150 6132 6176 121601 6135 6134 6137 9532 6136 6171 6170 6173 6128 8976 6129 4691 6142 6141 6144 6143 6146 6147 6181 6139 1052 6138 23168 79577 80349 123169 9646 54623 8829 5604 5605 4793 375790 3656 257397 23118 3339 5609 10313 6416 79760 91662 27072 84818 4131 6607 3442 23339 3441 9908 10146 25820 3440 1107 79833 11218 54797 5610 23765 10332 6441 11311 55090 3452 4153 3066 3451 25929 80306 5479 3449 7555 3448 10207 3447 23512 57617 64601 4939 3446 23367 3445 26762 23097 54960 3444 55823 3443 11123 6837 8487 7284 219541 65082 23389 2932 3456 9111 1452 55588 79685 92359 9636 50628 9412 26007 1524 3605 400569 112744 8974 30835 54431 283208 51726 5033 10527 5230 2678 2687 2023 8819 4780 598 1387 6667 5777 2002 10000 5747 54463 7474 51742 8324 3725 111 112 113 114 115 107 108 109 196883 11045 4072 5025 2268 4843 3710 5593 5027 143 2931 56965 64174 83666 84875 79668 54956 54625 1398 2778 79643 3708 51652 3709 197259 929 79792 91782 3552 2339 92421 3553 837 9146 11151 3837 26276 5868 11035 22937 27243 128866 55666 10134 10015 29082 9685 25978 23643 7099 3606 4836 84061 11282 7841 29801 25921 253832 51201 55741 1650 11320 51125 4247 51304 100128731 4249 6185 10461 7991 4124 4245 6184 25834 23193 58505 201595 6383 79651 2530 221914 79844 136 821 9332 11253 2781 9672 5589 51114 10082 6385 746 1603 3703 2262 6382 2239 2719 2817 8767 57506 4067 695 9868 6175 8678 375 3716 5478 7353 4088 4089 7297 114548 3586 1982 8672 317649 3838 89122 10768 4792 10392 317772 23586 1800 85235 64426 9789 23478 7706 60559 28972 90701 10254 84282 6881 6885 8027 6868 7187 7189 221613 2697 92815 10454 8969 9817 440689 64127 4690 8737 51616 64135 7415 5781 8517 51606 5594 5595 30849 51639 53938 8896 81608 208 10898 23283 1500 51645 5289 26999 22987 9899 6654 24148 6843 55696 9900 55339 10945 1479 1478 1477 85437 23020 85313 10992 9879 9410 10810 4644 8683 10084 11051 9775 5295 5725 63916 10523 5170 9785 54106 10291 7098 10978 199746 53981 808 9416 8449 9382 1794 1793 10181 8106 51692 815 7852 1234 57794 5500 6714 816 10189 4670 817 22938 818 51340 51585 22826 22827 10284 10283 8241 5093 5094 51593 23350 10286 10285 988 9343 6632 57461 84844 56259 51362 6627 6629 7979 6628 220988 10262 10946 23450 23451 54883 6634 57105 56949 6633 6636 5546 6635 6638 6637 928 10907 9360 4904 10914 10594 10236 11325 55749 27238 10921 11338 4057 29894 3309 6430 6432 6431 1660 8175 23524 1655 10450 6427 6426 9076 6429 57703 7097 6428 7096 1191 8189 51729 5356 27339 1665 920 84991 10465 3181 3188 3187 3185 3184 1901 1511 2521 9716 51503 10421 3192 285755 3191 11100 64225 3190 689 5499 440400 1993 9295 4666 91937 550 83443 7301 7307 4061 51234 22924 10949 2961 2960 2959 2958 2957 2194 4233 3065 1499 5824 6908 6804 999 9861 6233 3654 3312 7316 7514 3162 10213 7534 81857 8021 5706 5707 5708 5709 1981 207 5700 5701 5702 7529 5704 5705 5682 5683 5684 5685 5686 80273 5717 834 5718 5719 3676 1994 1432 11047 5713 5714 5690 10628 5691 5692 6844 1024 5693 5694 7311 5695 7314 4790 26986 54464 3304 10965 5687 5688 5689 79109 23327 718 2146 5045 7431 9475 8452 10250 9844 27316 10053 8907 8905 6093 130340 3183 1174 10025 162 55690 79869 164 6772 3105 940 567 926 64398 892 3661 340061 29110 3276 81030 10001 81631 7405 5987 8726 29079 9397 2342 5469 3320 5335 867 1956 3978 1616 54457 5925 8970 6421 8331 8337 128312 9862 8334 8335 2033 8370 1974 1973 8968 8341 8342 8347 8348 8345 3013 3570 8340 8338 255626 6732 653604 3018 3017 85236 6886 8349 6456 6455 2060 861 6457 54815 1938 23028 6907 79718 84246 9612 8841 9611 346562 9443 9441 9442 2874 9440 51586 9439 10109 10155 10552 10093 10092 10095 10094 10610 2810 10097 10096 6483 2771 2770 6482 6484 6487 9219 2773 7296 9477 6480 112950 256435 8148 51517 83737 8813 27090 7295 8818 1514 7082 54344 9282 SARS-COV-1 ACTIVATES MODULATES INNATE IMMUNE RESPONSES%REACTOME%R-HSA-9692916.2 SARS-CoV-1 activates modulates innate immune responses 7706 5478 861 83737 5970 64135 5094 3837 3656 11035 114548 834 7187 7189 3661 3838 340061 29108 29110 4792 6441 7311 23586 5479 7314 4790 2280 6233 80143 57506 11123 9641 684 7316 9111 9868 10465 26007 51284 9360 PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME DATABASE ID RELEASE 95%5576894 Phase 1 - inactivation of fast Na+ channels 30819 3750 3752 30818 30820 80333 3751 VESICLE-MEDIATED TRANSPORT%REACTOME%R-HSA-5653656.4 Vesicle-mediated transport 10618 554 10052 57165 375519 57369 2702 2701 2700 127534 375056 2709 4074 2707 2706 1759 2705 81846 2703 219770 125111 1601 10804 81025 84694 8218 56894 149371 10959 55763 8729 5321 55770 117177 23265 338 26052 60412 378 54536 8766 79643 51652 966 10640 11336 1604 91782 1121 92421 6709 5864 5867 6857 9146 5868 8533 64708 27243 10987 10980 128866 10971 29082 50813 9685 25978 10920 10113 3146 9570 55860 51164 11015 55738 830 10671 1639 6453 93661 84516 2665 10890 2799 4124 5879 6305 9332 22878 8871 22879 4036 221960 79890 84958 80006 2664 5870 23396 57465 8867 51762 23682 83874 11345 729873 10260 6764 4738 9230 9909 84315 6836 51256 160518 5869 22931 163259 126432 9363 26130 3257 5878 27342 79958 9135 375 201627 338382 125058 163486 54662 201475 55357 1122 5898 57533 6845 11337 3240 11021 3482 79735 57706 5872 23258 79961 26000 1075 116442 60684 23011 10981 5866 84079 154 22898 54453 55667 829 27147 51622 377 4943 259173 89781 23637 9610 156 64786 414918 51112 7532 7531 51552 7533 3043 157 10254 8027 408 10342 409 1080 3092 8546 5049 1362 11031 2804 143425 2697 6811 6572 374403 8398 832 6396 57679 6711 9342 81567 23433 1522 8655 9183 58485 1062 1315 3630 1856 5048 8301 26958 9585 8774 51143 208 8775 27128 23046 24137 57589 10139 26153 143187 55605 636 60592 23299 22920 55850 84316 23256 9322 10945 400 1781 5286 63908 51014 1780 57511 55614 146909 1778 81930 8674 8677 8675 84643 339122 55582 3796 23423 29988 23303 4644 250 372 5873 51542 84342 91949 7110 4121 1783 4122 381 5050 9371 221458 51272 662 1523 57134 547 10244 9648 50618 9527 23647 140735 9267 9265 11004 9266 55083 808 22796 79571 2590 9382 2890 51560 25782 347517 113220 3797 3832 10972 3833 3834 3835 90990 9950 25839 9276 9712 285643 90196 10228 122830 11316 83548 23095 10749 27333 2803 10905 60561 286 60560 10466 9827 9321 22818 22930 6293 2800 1314 10133 124602 915 54732 56992 4218 54734 917 51226 83452 738 53407 64147 27314 22820 55275 51594 4641 11014 9609 5265 2153 185 3575 351 29924 26119 58513 1213 8408 1211 51128 2157 160 30011 161 163 6708 6710 213 6712 335 6810 6814 1175 1173 3949 1785 23166 4627 284297 922 22872 6280 5874 7018 84313 51028 11267 9871 9632 1294 920 57731 10427 287 288 51332 8673 2801 1129 811 388552 9185 55330 2580 950 22848 286749 10717 90019 8906 55576 112574 1176 23208 6643 115548 23216 54885 152503 84062 23431 8322 23557 25977 9554 3267 85021 286451 9829 9847 57186 9856 9882 23149 85439 51429 9892 134829 64746 1839 157807 6272 273 274 11154 55707 9698 11252 84251 7164 7163 27131 1861 26258 27348 29763 22905 9026 79058 1777 57148 51399 29993 2647 9179 29978 29979 5563 7248 5564 5565 51422 10525 8578 5571 10808 3040 382 6233 127833 53632 7249 3312 8773 7316 5537 79090 22870 7534 11070 9341 9117 11196 254263 81562 1453 27095 149111 9919 89866 7109 4253 6399 207 2348 7879 23243 10175 126003 25956 55014 7529 10802 10652 51693 3998 122553 10540 10484 83696 90411 10282 4012 26984 79748 55291 128637 10960 6844 7311 29127 10121 7314 11258 1278 1277 7037 2589 4952 11127 55048 89853 51534 9525 137492 27183 51271 10053 8907 51160 155382 8905 130340 93343 1174 7251 79720 162 2873 164 51510 51138 23163 4481 9318 286133 4646 8685 2495 26088 1284 1282 1281 23048 7184 117156 2512 54874 81035 78989 23062 5648 81631 26286 4035 3320 1950 3512 867 259 1956 3263 3250 84364 8976 6517 9493 10112 6288 6456 6455 2060 6457 6678 5052 10226 4905 1212 348 11311 22836 3798 3799 2017 948 10109 10552 10093 10092 10094 10097 2810 10096 64837 51209 89953 147700 9367 3831 551 374 81876 5861 8542 7082 6869 64689 7039 685 255324 2069 8615 10000 7474 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-HSA-68962.6 Activation of the pre-replicative complex 23649 5422 5557 5558 1017 8317 8318 29935 10926 56655 55388 5426 5427 54107 4172 4173 4174 4175 4176 4171 990 84515 51053 5000 6117 5001 6119 23595 23594 6118 81620 4998 4999 MIRO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9715370 Miro GTPase Cycle 22906 5910 66008 80179 55288 89941 9927 55669 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME%R-HSA-77588.5 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 4686 6634 84967 134353 6636 6635 25888 7884 6628 6637 22916 SIGNALING BY LRP5 MUTANTS%REACTOME%R-HSA-5339717.5 Signaling by LRP5 mutants 27121 79412 83999 27123 22943 4041 COMPLEMENT CASCADE%REACTOME%R-HSA-166658.6 Complement cascade 629 718 721 710 3080 4179 1361 1380 2219 10877 10878 730 731 27202 4153 732 78989 930 5648 733 975 712 1191 735 713 81494 714 715 716 717 719 2220 3078 1401 8547 3075 10584 1370 3426 1369 722 966 725 727 728 729 1604 7448 1991 1378 2147 5627 1675 3004 NGF-STIMULATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%9031628 NGF-stimulated transcription 6938 4209 6457 6446 1020 7166 6236 2152 3399 4066 8941 8061 466 3727 1785 7425 3400 8851 2354 10221 4664 4665 1959 1958 3398 3397 23237 6722 5978 1961 2033 1960 429 1386 2353 3726 2002 1108 DEFECTIVE OGG1 SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 95%9656255 Defective OGG1 Substrate Binding 4968 NAGS VARIANTS CAUSE NAGS DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9955693 NAGS variants cause NAGS deficiency 162417 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME%R-HSA-918233.4 TRAF3-dependent IRF activation pathway 3661 7706 2033 29110 89122 23586 64135 84282 80143 57506 9641 3665 3456 7187 1387 TRANSPORT OF RCBL WITHIN THE BODY%REACTOME%R-HSA-9758890.2 Transport of RCbl within the body 4036 51293 6948 6947 5826 4363 26119 55788 EXTENSION OF TELOMERES%REACTOME%R-HSA-180786.4 Extension of Telomeres 55135 1017 7015 2237 10856 100134934 8607 5537 55505 54433 23649 55651 5422 79991 5557 5558 54921 23243 10714 5424 5425 5981 57804 3978 80119 7486 5982 55164 1736 5983 55291 63922 80169 79075 51750 5111 26277 25913 7013 641 65057 1763 7014 6117 5984 54386 5985 890 6119 8900 6118 MUCOPOLYSACCHARIDOSES%REACTOME%R-HSA-2206281.5 Mucopolysaccharidoses 138050 6448 3425 4669 411 2720 2588 3423 2990 2799 3373 DEFECTIVE TPMT CAUSES TPMT DEFICIENCY%REACTOME%R-HSA-5578995.4 Defective TPMT causes TPMT deficiency 7172 FORMATION OF AXIAL MESODERM%REACTOME DATABASE ID RELEASE 95%9796292 Formation of axial mesoderm 6862 4087 8928 4088 3170 1499 3169 344022 51176 7004 6932 6469 8463 10413 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 95%389977 Post-chaperonin tubulin folding pathway 10383 6905 10382 112714 79861 81027 402 7846 84790 10376 84617 6902 80086 113457 6904 6903 1155 51807 7280 347733 7277 10381 7278 SODIUM CALCIUM EXCHANGERS%REACTOME%R-HSA-425561.4 Sodium Calcium exchangers 6546 9187 123041 6543 6547 6717 283652 808 57419 25769 80024 DEATH RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 95%73887 Death Receptor Signaling 27005 4803 6610 6885 6868 4099 7186 57142 4974 7189 84894 55512 29110 56957 355 356 8772 9641 7332 10454 9530 1540 8737 329 5584 5970 841 396 330 84888 25999 8439 56928 7124 7204 9500 8517 55160 10273 23365 10616 9181 8717 128272 57580 4804 10018 26230 121512 1894 23421 10451 8743 7410 84904 100271715 26084 23370 25791 89846 9826 54848 9828 387 7409 23229 1147 22899 5663 8795 6654 50649 23385 8997 55851 6453 8887 5664 8793 7984 83464 29 8797 8874 51107 64857 572 3065 57449 389337 445328 2245 23263 3551 50650 8878 4615 26574 221472 5599 9639 10672 10276 257397 55701 23118 5879 9459 9138 11108 4168 27018 27237 7074 8837 6655 11214 8841 5924 3066 220213 7132 55072 9825 7323 6233 7322 8767 3654 9261 7316 7321 9099 10133 7185 10399 7375 835 90268 7128 4792 843 7311 7314 7531 4790 8408 142678 331 836 81858 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME%R-HSA-168181.9 Toll Like Receptor 7 8 (TLR7 8) Cascade 121260 6885 7186 7189 79155 7157 7335 3665 10454 64127 929 8945 5970 353376 841 7334 148022 8517 3146 23643 5594 5595 1386 7099 57162 51311 5604 5598 51231 1849 84166 1147 1848 6285 1846 6288 1845 92610 6283 51295 51135 4214 9684 4793 28512 57161 79671 3551 177 4615 121457 246330 5599 28511 3656 257397 23118 1326 5609 466 80216 6416 4208 5601 7867 5602 5606 5519 54106 5515 5516 5518 6233 8767 3654 9261 7316 5528 4791 5608 9097 23291 11274 1432 4792 10392 7311 80231 6197 3663 7314 6196 351 4790 9252 6195 8454 4205 2353 5600 2002 6500 3725 51284 INTERLEUKIN-12 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 95%447115 Interleukin-12 family signaling 5908 4001 6772 821 759 6175 3181 9987 9049 6648 6775 9446 3185 4507 5062 3717 375 3716 3936 654483 3313 5478 6647 5898 6845 6888 7297 4282 5055 3595 3594 3593 3592 1072 27250 302 1265 3586 5721 4478 6950 2939 5306 829 149233 51561 998 6627 3572 3458 10148 6774 5034 246778 9466 9244 LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME DATABASE ID RELEASE 95%3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 3661 2033 9208 1499 1387 REGULATION OF GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 95%9968551 Regulation of GBP-mediated host defense 2633 2810 5292 834 TRANSCRIPTIONAL REGULATION OF TESTIS DIFFERENTIATION%REACTOME DATABASE ID RELEASE 95%9690406 Transcriptional regulation of testis differentiation 6662 1761 5730 7490 23414 2516 50846 2254 6736 268 2626 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME DATABASE ID RELEASE 95%2046104 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 10005 60481 3992 64834 2180 9415 6342 3295 30 215 83401 54898 INTESTINAL HEXOSE ABSORPTION%REACTOME DATABASE ID RELEASE 95%8981373 Intestinal hexose absorption 6523 6518 6248 6514 TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX%REACTOME%R-HSA-1362277.3 Transcription of E2F targets under negative control by DREAM complex 3065 5933 7027 5934 91750 5111 132660 993 286826 1875 55957 5928 1874 990 4149 7029 1869 7153 4609 SYNDECAN INTERACTIONS%REACTOME%R-HSA-3000170.4 Syndecan interactions 6382 3693 7057 7448 3371 7040 2247 87 3691 51399 3690 3655 3685 6383 3673 5578 3688 9672 6385 8573 SIGNALING BY VEGF%REACTOME%R-HSA-194138.4 Signaling by VEGF 10006 9475 5566 5567 5568 9844 6093 3710 4846 25759 6300 5603 8877 1398 5829 3708 1003 3709 253260 4690 3320 5335 5063 2185 9564 5590 3728 5921 4893 14 998 117145 10451 7410 3690 1495 3685 208 8440 1500 8829 387 7409 26999 3265 57761 1499 10810 5879 5295 7867 5296 5290 5291 63916 5170 55615 558 6461 64223 808 5580 9261 2475 1793 3315 9047 5578 7422 2324 3791 7424 7423 2277 2321 5228 5062 1536 1535 10458 207 55845 8828 4688 4689 2534 8936 1432 10787 5579 10152 10768 857 5600 3071 5058 10000 10163 5747 23191 653361 79109 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME DATABASE ID RELEASE 95%1169410 Antiviral mechanism by IFN-stimulated genes 7706 5611 5045 60 6772 6622 1660 2176 8575 7157 3661 6895 5292 7318 115361 2635 115362 2634 5229 8877 348995 9883 2316 6396 199990 4734 129401 55120 2189 9688 91442 80233 2175 57122 2188 2187 23225 3836 57697 2178 4927 23165 55746 55706 2342 23636 4690 9631 7175 9972 5335 11097 23279 2339 8086 23511 53371 4869 8480 79023 79902 10762 3837 5903 6059 7334 3608 5771 1974 1973 8517 103 5595 6774 3609 1147 3306 3305 378708 3839 2633 402569 3840 3841 54920 3551 5300 8894 9775 201626 6041 1965 4938 4940 8638 5519 1968 7341 25820 5610 71 1977 7329 5515 5516 5518 6233 4939 57506 9246 5525 3312 7316 2810 9636 8678 8021 5608 3716 7324 1981 983 3434 4600 9470 2317 1982 8672 317649 834 5495 4599 11274 201254 3838 7311 23586 7314 3304 51191 FGFR4 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 95%1839128 FGFR4 mutant receptor activation 2264 DEFECTIVE SLC34A3 CAUSES HEREDITARY HYPOPHOSPHATEMIC RICKETS WITH HYPERCALCIURIA (HHRH)%REACTOME%R-HSA-5619097.4 Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) 142680 MACROAUTOPHAGY%REACTOME DATABASE ID RELEASE 95%1632852 Macroautophagy 8100 10013 1080 29110 9804 10533 65018 4077 81631 5830 7405 7335 7332 79643 51652 84749 91782 3320 92421 8655 22863 7415 7334 7417 27243 7416 7419 128866 29082 55062 25978 30849 51143 200894 5289 1781 1780 1778 8878 5562 5563 7248 1783 10226 5564 5565 389541 28956 115201 55054 123 57521 51001 89849 55004 8649 285973 56270 51422 55626 10670 6009 9776 23710 84971 440738 140735 5571 9821 60673 64121 64223 11152 84938 54543 83734 153129 7323 64422 6233 7322 23192 2034 9927 26100 11345 53632 2475 55669 7249 3297 58528 10542 3312 10325 7316 9868 8678 8897 10452 11337 10133 100188893 472 5116 5071 401505 1460 1459 56993 1457 7311 7314 9140 8408 9474 79065 84557 139341 1068 11315 64419 ORGANIC ANION TRANSPORT BY SLC5 17 25 TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%428643 Organic anion transport by SLC5 17 25 transporters 1468 6576 160728 159963 26503 8402 PI-3K CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 95%5654720 PI-3K cascade:FGFR4 2251 8074 2549 2249 2247 10818 2246 152831 8823 8817 5295 26281 9965 2264 5781 5290 2254 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME DATABASE ID RELEASE 95%216083 Integrin cell surface interactions 3679 6696 3693 3694 3386 3371 3385 4060 3384 682 3383 375790 3687 3381 7087 3339 1311 3673 3688 1297 8516 7412 1284 1282 3684 1286 1285 58494 999 960 961 91522 5175 3689 1305 3791 2335 1307 2244 2266 7057 7448 3683 8515 2243 50848 3676 3681 3682 3695 83700 2200 3696 3672 3690 80781 3680 3675 3655 3685 3674 3678 22801 1299 1298 PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME DATABASE ID RELEASE 95%112308 Presynaptic depolarization and calcium channel opening 27092 781 782 783 784 785 773 774 9254 55799 777 10369 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME DATABASE ID RELEASE 95%1236975 Antigen processing-Cross presentation 6810 6279 3105 567 6280 7097 7096 929 8673 114609 29927 811 2209 5720 6271 8517 3146 23643 9554 7099 3685 50489 1147 3693 2923 3551 4615 3107 3106 3134 3133 55176 9861 6233 948 9902 6890 6892 8773 7316 6891 695 10213 23480 9341 5706 3135 5707 1536 2244 2266 5708 5709 1535 4360 5696 5700 5701 4688 2243 4689 5702 1520 5704 5705 5682 5683 5684 5685 5686 5721 4012 5717 1514 5718 5719 5698 11047 5699 5713 1515 5714 10333 5690 5691 5692 5693 5694 10952 7311 7979 5695 7314 5687 5688 5689 653361 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190241.3 FGFR2 ligand binding and activation 2252 27006 2255 2251 8074 9982 2249 2248 2247 2246 83888 8823 8817 26281 143282 2254 TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%5656169 Termination of translesion DNA synthesis 7706 9100 10714 5424 51455 5425 5981 57804 5982 56655 5983 5429 5426 5427 51426 9768 124739 54107 7318 7311 5111 7314 11201 6233 9246 6117 7316 5984 5985 9636 6119 6118 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 95%2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 83464 51107 3065 10013 10014 6907 79718 9734 6868 51564 3714 9612 8841 9611 23493 3516 4609 892 3066 9759 23462 8850 6233 3280 9978 79885 7316 55869 22938 55534 83933 9794 2648 1387 2033 28514 1024 182 7311 7314 84441 8454 9148 10046 54492 4851 142678 26508 388585 6500 57534 102 54567 5663 23385 55851 5664 PDE3B SIGNALLING%REACTOME DATABASE ID RELEASE 95%165160 PDE3B signalling 208 5140 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%R-HSA-936440.6 Negative regulators of RIG-I MDA5 signaling 7706 1540 79671 5300 83737 55593 64135 84282 5094 7187 3661 7128 29110 89122 7318 7311 23586 7314 7323 7322 6233 3093 9140 57506 9246 9474 51191 9641 7316 9636 84166 54476 8887 7321 54941 TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-HSA-6803207.2 TP53 Regulates Transcription of Caspase Activators and Caspases 7161 843 58484 8738 55367 8626 834 317 835 472 839 7157 FOLDING OF ACTIN BY CCT TRIC%REACTOME%R-HSA-390450.5 Folding of actin by CCT TriC 22948 10575 908 6950 7203 60 10574 10693 10576 10694 FGFR2 ALTERNATIVE SPLICING%REACTOME%R-HSA-6803529.3 FGFR2 alternative splicing 2963 2962 5434 5435 5436 5437 5438 5439 22916 5430 4686 5431 5432 5433 5725 23543 54845 80004 3178 7073 7072 5440 4670 5441 3187 3185 DISINHIBITION OF SNARE FORMATION%REACTOME DATABASE ID RELEASE 95%114516 Disinhibition of SNARE formation 5579 5578 6810 5582 6814 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 95%380287 Centrosome maturation 10383 10382 1781 1778 7846 5566 9793 7277 5518 9738 9662 7840 11064 22994 22995 7283 10733 80321 203068 114791 55722 1454 1453 3320 55125 9814 85378 11190 115106 79441 95681 10426 27175 1069 653784 54801 983 10142 9702 10540 8655 5347 5108 11116 4751 29922 55142 22897 27229 54930 5116 79959 80184 93323 5577 728642 23354 22981 440145 8481 10844 80254 121441 55755 23332 984 7532 10806 10121 7531 55559 8636 22919 11258 80097 5048 84131 4957 55835 54820 FORMATION OF THE EMBRYONIC STEM CELL BAF (ESBAF) COMPLEX%REACTOME%R-HSA-9933946.1 Formation of the embryonic stem cell BAF (esBAF) complex 6597 6599 6598 55274 60 9274 9275 5977 6601 8289 6603 6602 6605 6760 53335 6604 64919 605 86 RUNX3 REGULATES NOTCH SIGNALING%REACTOME%R-HSA-8941856.2 RUNX3 regulates NOTCH signaling 2033 182 84441 8850 3280 10046 4851 864 9794 2648 22938 1387 3516 55534 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME%R-HSA-69183.4 Processive synthesis on the lagging strand 23649 5422 5557 5558 5111 10714 5424 5425 57804 3978 1763 2237 6117 6119 6118 TGFBR3 EXPRESSION%REACTOME DATABASE ID RELEASE 95%9839394 TGFBR3 expression 5914 6938 4088 4089 6667 4343 2033 192669 23112 7049 27327 26523 4613 192670 27161 57690 6929 6256 6925 4617 4618 4654 4656 83855 3070 SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS%REACTOME%R-HSA-6802946.3 Signaling by moderate kinase activity BRAF mutants 673 8826 2244 2266 7414 8844 10256 54518 5894 22866 5906 4140 5908 7450 5037 2243 7094 1445 7529 369 283455 408 409 4893 4296 3845 808 5594 5595 3690 3674 815 6714 5604 816 5605 817 8315 818 5245 2335 3265 3717 ACTIVATION OF TRKA RECEPTORS%REACTOME DATABASE ID RELEASE 95%187015 Activation of TRKA receptors 116 117 4803 135 4915 4914 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND ALVEOLAR CELLS%REACTOME DATABASE ID RELEASE 95%9927426 Developmental Lineage of Mammary Gland Alveolar Cells 5617 GAIN-OF-FUNCTION MRAS COMPLEXES ACTIVATE RAF SIGNALING%REACTOME DATABASE ID RELEASE 95%9726842 Gain-of-function MRAS complexes activate RAF signaling 673 22808 5894 5500 5501 8036 7529 369 METABOLISM OF POLYAMINES%REACTOME%R-HSA-351202.7 Metabolism of polyamines 5706 5707 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 5690 5691 5692 1728 5693 5694 7979 5695 9861 196743 5687 4947 5688 51582 79814 5689 6303 51686 6723 4946 262 6611 113451 4953 10213 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 95%392170 ADP signalling through P2Y purinoceptor 12 2782 2788 2787 2786 55970 2785 2784 2783 51764 10681 64805 54331 2771 2770 59345 94235 2793 2792 346562 2791 2790 2773 TOXICITY OF BOTULINUM TOXIN TYPE B (BOTB)%REACTOME%R-HSA-5250958.4 Toxicity of botulinum toxin type B (botB) 6844 6857 127833 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 95%2029485 Role of phospholipids in phagocytosis 10768 5335 122618 196051 5580 8398 84513 23646 2209 917 5337 5338 3710 5295 3708 5296 3709 6850 5581 5290 5336 5291 2214 2212 DEFECTIVE CYP11B2 CAUSES CMO-1 DEFICIENCY%REACTOME DATABASE ID RELEASE 95%5579009 Defective CYP11B2 causes CMO-1 deficiency 1585 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME%R-HSA-112315.8 Transmission across Chemical Synapses 113 114 115 2774 1312 107 783 108 109 196883 6853 5566 5567 5568 1103 22999 6540 18 80331 10815 5864 140679 6616 6857 6529 7915 6511 5573 5575 5576 5577 5613 6506 6505 6507 81539 5330 5331 23236 6512 6539 54407 23229 5879 5562 217 5563 5564 5565 5924 6804 51422 2572 5571 2571 53632 3312 5578 4193 6582 590 6571 8541 8497 8499 8500 6580 10497 2793 2792 8224 6854 2791 2790 5582 3838 5579 2788 10645 6844 2787 26960 2786 84254 2785 6197 2784 6196 2783 51764 6195 43 28964 94235 27163 55970 54331 220074 59345 6532 773 4646 774 8573 777 55327 22843 27330 2782 320 781 116443 782 116444 8536 784 785 64130 2892 8825 57030 57576 2893 10681 9647 6572 5923 10550 55799 9256 55584 4893 5594 5595 6538 9463 3760 3761 2550 3759 3359 3265 200909 3772 2562 2561 2560 2559 2558 2557 83988 2556 2555 2554 2036 3762 3763 3765 3766 27092 3768 7102 2570 23426 2569 4905 2567 2566 3773 346562 9495 55879 170572 5170 10369 10368 8973 1143 1142 1141 59283 2900 1138 2743 808 1137 1136 88 2742 2891 1135 2890 3084 2741 1134 1742 2901 1741 1740 285242 2906 200959 1146 1739 2905 1145 815 1144 2904 9568 4900 2771 6714 2770 2903 27020 816 89832 4747 9177 2902 8001 817 2899 818 2898 2897 2773 80852 27165 2744 2752 60482 814 6531 4128 160 111 112 9254 DIGESTION AND ABSORPTION%REACTOME%R-HSA-8963743.4 Digestion and absorption 11181 8513 8544 2980 280 119548 27159 278 279 1056 2981 5407 3938 5406 5408 6476 1208 1118 248 6518 8972 2984 6514 6523 6248 INTRAFLAGELLAR TRANSPORT%REACTOME%R-HSA-5620924.5 Intraflagellar transport 112752 255758 8100 51626 90410 51098 79989 79809 80173 26160 11127 57728 9321 3842 57539 8655 9371 140735 57576 23059 3797 28981 150737 51668 55112 11020 57560 56912 6991 64792 92104 9742 83657 200132 55081 83658 55764 26146 89891 79659 22920 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 95%69231 Cyclin D associated events in G1 7027 1029 1021 595 1019 1017 894 896 1871 1026 898 1875 1870 1874 6502 28227 9134 1028 1027 902 7029 1869 5925 5520 5519 1030 1032 1031 1163 5933 5515 7311 5934 5516 7314 5518 8454 6233 4067 7316 5753 6500 25 4331 1022 3717 MITOCHONDRIAL TRANSLATION INITIATION%REACTOME%R-HSA-5368286.3 Mitochondrial translation initiation 6150 55168 64949 28973 65080 51642 54998 5018 10573 11222 128308 51649 9553 64960 92259 64963 63875 64965 64968 55052 55173 64969 51373 26284 51650 51253 60488 51258 219927 29074 56945 28998 64975 79590 64976 64979 64978 23107 28957 64928 7818 51263 29088 51021 57129 54534 51023 51264 51069 84545 78988 122704 65993 64981 10240 64983 3396 63931 26589 54460 6182 123263 6183 118487 51073 116540 740 124995 4528 54148 116541 55037 29093 9801 51116 10884 54948 51318 219402 64432 65003 64951 65005 65008 28977 90480 51081 ATORVASTATIN ADME%REACTOME DATABASE ID RELEASE 95%9754706 Atorvastatin ADME 54659 1576 5243 5446 10599 5444 1244 28234 METABOLISM OF RNA%REACTOME DATABASE ID RELEASE 95%8953854 Metabolism of RNA 4839 4850 55720 5394 28987 4848 8780 54881 26168 4849 81875 79159 51388 90459 8568 55759 705 79707 57418 23246 23481 26354 55131 81887 84946 10438 55781 117246 83732 10969 10200 55253 55039 9836 57570 127253 129450 10128 81892 55149 103 104 27350 29974 164668 403314 200315 339 9582 10930 9652 10767 115024 28960 6175 5440 8732 5441 4331 8731 1022 2071 2966 6829 2965 2963 2962 2068 5434 5435 5436 5437 5438 5439 2968 2967 404672 5430 5431 5432 5433 902 22803 6499 11044 10528 348995 9883 6396 129401 9688 57122 23225 4927 23165 55746 55706 23636 9631 7175 9972 11097 23279 8086 23511 53371 8480 79023 79902 10762 5903 6232 84967 134353 85456 9337 51808 51639 53938 9984 8896 81608 57187 10898 84324 23283 11066 51645 10772 84321 11193 9877 24148 55696 79084 24144 55339 8899 64852 55100 1479 9125 26097 1478 1477 85437 23020 85313 143884 10992 9879 8563 9410 10081 8683 10084 11051 9775 23398 9092 3550 22868 22985 55234 285367 55110 26995 387338 55599 8559 55178 5725 130916 58509 51001 10523 79922 6936 29960 81554 9785 10291 51335 59286 84881 29107 51106 10978 79576 5515 199746 53981 5518 84248 9416 8449 56339 10179 58517 728343 10181 8106 51690 51692 51691 57794 5500 51213 112858 11157 10189 8233 4670 22938 64895 151903 51340 10713 51585 5511 55702 5514 22826 22827 10284 5411 9924 255967 10283 153527 8241 5093 5094 60625 84811 22916 51593 4686 23350 79228 10286 10285 988 55954 11017 9584 5520 9343 6632 154007 6631 9589 10929 57461 84844 56259 51362 6625 6627 6626 6629 135295 7979 6628 220988 10262 27258 84950 10946 23450 23451 54883 6634 56949 6633 6636 5546 9238 6635 60493 6638 10073 84271 1207 6637 9128 9129 10907 26017 9360 2926 80145 4904 10914 10915 10594 7737 10236 11325 55749 10482 27238 63932 9130 10921 11338 2733 29894 4236 79706 57819 4116 84081 6430 25949 7884 6432 6431 79171 1660 22794 8175 23524 1655 4809 10450 6427 91603 6426 9939 6429 57703 10212 6428 1659 23658 8189 51729 5356 55094 27336 27339 79165 1665 26121 84991 10465 163859 25804 3181 3188 65109 3187 3185 10642 3184 57721 79753 55660 2521 7536 9716 51503 51747 51095 3192 3028 3191 23517 54931 3190 9692 23759 60528 5499 9295 10569 79622 6230 83443 6210 51634 7307 6231 6234 51759 6235 6191 2197 6193 6192 6194 51065 140032 6205 6227 6204 6207 6229 6206 6228 6209 6208 6188 6187 6223 6201 6189 6222 6203 6224 6202 3178 6218 6217 3921 134637 81605 79897 55687 51002 51367 11102 91801 54517 54913 10775 115708 80746 54482 84705 24140 51493 60487 54802 54888 7919 54920 10785 10940 4234 8270 339487 283989 55621 283742 25904 152992 64172 63892 348180 116461 2058 10419 83480 10248 11260 113179 79691 25821 79693 1975 1653 55006 55571 55644 81890 84520 51605 93587 90353 1977 221078 79042 23536 1787 5901 246175 5580 79074 10799 9861 10557 6233 11340 54974 8570 84267 57604 9261 23404 51504 3315 10556 54512 54901 3312 51637 677 7316 7514 5578 55802 64282 10213 87178 5393 10644 55505 8741 64062 7534 10643 23016 6832 54433 8021 23211 5073 1454 5706 25996 1453 5707 196441 55651 5708 124245 51010 84186 5709 54439 167227 91746 64848 1981 51013 23144 207 1797 5700 5701 3842 5702 7529 118460 5704 5705 5682 5683 5684 5685 1736 5686 22894 5717 5718 5719 1994 1432 56915 11047 7538 5713 5714 5690 5691 5692 5693 5694 7311 5695 7314 10171 8125 26986 79050 84916 54464 3304 23160 5687 10813 27042 5688 5600 55127 5689 54555 6418 84128 51202 8602 92856 11103 65083 9277 25879 9790 51096 55813 5822 27292 56902 2091 115939 25926 114049 27340 10436 27341 57647 55623 55226 88745 10199 6434 9136 22984 10250 57050 55272 51077 27316 10607 11056 9724 3183 84135 134430 51118 10885 79869 5930 51428 6152 6155 6154 6157 9349 6156 6159 6158 23521 51121 11224 6164 200916 6166 6122 6165 6124 6168 6123 6167 6169 6125 116832 25873 6160 6161 140801 4736 6130 6133 9045 6132 6176 6135 27043 6134 6137 6136 6171 6170 6173 6128 4691 6129 6142 6141 6144 6143 6146 6147 6181 1974 6139 1973 6138 219988 23644 1656 196513 79670 27257 80349 80153 23318 10605 9188 79760 23019 6607 79833 11218 25888 25929 55596 54960 8487 50628 2107 23708 2935 57472 80335 23049 23293 9887 55181 26019 23381 55629 5976 65110 56006 51602 96764 29883 MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 95%68882 Mitotic Anaphase 200014 260334 79643 51652 91782 92421 3837 27243 128866 29082 25978 7341 7329 5901 9861 6233 7316 7514 10213 5706 5707 5708 5709 5700 5701 3842 5702 5704 5705 5682 5683 5684 5685 5686 113457 5717 5718 5719 7280 11047 5713 5714 5690 5691 2010 5692 5693 5694 7311 5695 7314 3930 5687 10376 5688 5689 9133 80086 51807 23592 10381 10383 10382 112714 4001 7846 1104 84790 27183 84617 347733 7277 7278 79861 81027 348995 9883 6396 129401 9688 57122 23165 55746 55706 23636 9631 23279 23511 53371 79023 79902 8815 5903 54908 6232 8655 25909 8379 9183 1063 1062 9184 1060 991 8243 151648 55166 9126 23244 23047 1058 79019 10735 151246 23063 9735 5885 10274 23332 79003 55055 81565 22919 348235 5048 23421 220134 57082 57405 51143 23141 147841 4085 64105 401541 10403 54820 80776 701 54821 378708 1781 23122 1780 79172 1778 81930 55920 84643 3796 9793 91687 57551 79682 5905 1783 5501 83540 80152 2491 5519 332 55143 699 11243 3619 140735 5515 11004 5516 5518 9212 25936 11130 64946 79980 10726 5525 5526 55839 5527 5528 5529 51529 7321 8881 64682 25906 11065 8697 7324 10393 29945 27338 119504 29882 891 246184 983 996 51434 51433 5347 5520 22933 7979 113130 9700 6683 347688 7443 9798 221496 6249 9232 SIGNALING BY BMP%REACTOME%R-HSA-201451.6 Signaling by BMP 4086 4089 9765 4090 4093 657 658 659 94 268 64750 64388 9241 4091 2658 269 9350 4092 650 7049 27302 92 93 57154 3624 3623 7323 11167 91851 6497 7321 NUCLEAR RNA DECAY%REACTOME DATABASE ID RELEASE 95%9930044 Nuclear RNA decay 196441 124245 84186 51010 54439 91746 64848 23144 51013 1797 23517 80335 118460 22916 51593 4686 22894 56915 5394 11044 55596 11340 10179 23404 8106 10438 54512 10200 64282 5393 22803 64062 64895 23016 23211 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME%R-HSA-432722.5 Golgi Associated Vesicle Biogenesis 10618 9698 4952 6456 7164 7163 5286 27131 26258 9026 10053 2647 8907 8905 130340 1174 162 1785 164 408 2495 8546 2512 1362 2804 3312 5878 375 8673 81567 6845 3482 388552 55330 2580 10717 9685 1176 6643 6844 54885 152503 84062 23431 23557 25977 286451 8301 9829 8775 7037 51429 64746 6272 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME DATABASE ID RELEASE 95%3065676 SUMO is conjugated to E1 (UBA2:SAE1) 7341 6612 6613 10055 10054 SPERM MOTILITY AND TAXES%REACTOME DATABASE ID RELEASE 95%1300642 Sperm Motility And Taxes 117155 79820 157855 257062 117144 57828 84329 347732 378807 GLUCOCORTICOID BIOSYNTHESIS%REACTOME%R-HSA-194002.4 Glucocorticoid biosynthesis 3284 3283 1586 1585 866 3291 5443 3290 1584 1589 DEFECTIVE CSF2RA CAUSES SMDP4%REACTOME DATABASE ID RELEASE 95%5688890 Defective CSF2RA causes SMDP4 653509 729238 6441 6440 6439 1439 1438 DEFECTIVE FACTOR IX CAUSES HEMOPHILIA B%REACTOME%R-HSA-9668250.4 Defective factor IX causes hemophilia B 2158 2811 2160 2812 2157 2815 2814 2677 2159 LOSS OF MECP2 BINDING ABILITY TO THE NCOR SMRT COMPLEX%REACTOME DATABASE ID RELEASE 95%9022537 Loss of MECP2 binding ability to the NCoR SMRT complex 2874 79718 9612 8841 9611 6907 LOSS OF MECP2 BINDING ABILITY TO 5HMC-DNA%REACTOME DATABASE ID RELEASE 95%9022534 Loss of MECP2 binding ability to 5hmC-DNA REPRESSION OF WNT TARGET GENES%REACTOME DATABASE ID RELEASE 95%4641265 Repression of WNT target genes 1487 6932 6934 7088 166 7089 3065 7091 83439 7090 51176 1488 DEFECTIVE OPLAH CAUSES OPLAHD%REACTOME DATABASE ID RELEASE 95%5578998 Defective OPLAH causes OPLAHD 26873 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 95%2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 83464 51107 3065 10013 10014 6907 79718 9734 6868 51564 3714 9612 8841 9611 23493 3516 4609 892 3066 9759 23462 8850 6233 3280 9978 79885 7316 55869 22938 55534 83933 9794 2648 1387 2033 28514 1024 182 7311 7314 84441 8454 9148 10046 54492 4851 142678 26508 388585 6500 57534 102 54567 5663 23385 55851 5664 DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME DATABASE ID RELEASE 95%5654708 Downstream signaling of activated FGFR3 8074 5335 2549 2249 2247 10818 2246 10817 8823 8817 5295 26281 5781 6654 4893 5290 2254 3265 HIGH LAMINAR FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND PECAM1:CDH5:KDR IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 95%9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells 113 114 115 10266 107 108 55970 109 10203 196883 5566 5567 1499 5568 54331 2767 4846 59345 5296 5290 5291 5170 55615 2782 2776 64223 808 59341 10681 2475 5175 2778 9780 1003 2324 3791 253260 7414 84290 207 824 826 5029 7094 5586 2793 2792 5573 2534 5575 2791 5576 5577 2790 2788 2787 2786 2785 5293 2784 2783 51764 4323 94235 24145 79109 133 111 112 MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME%R-HSA-5223345.7 Miscellaneous transport and binding events 81614 1497 348938 56262 123606 57127 80131 7991 57380 55144 56172 79815 2039 5304 152519 54896 563 6005 23507 57185 120 118 119 93380 84061 51458 84230 NEPHRIN FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 95%373753 Nephrin family interactions 8826 4690 89 6709 88 87 81 8440 23607 6711 9863 5295 55243 5296 84623 84063 2534 4868 8976 5290 5291 8573 RESPIRATORY SYNCYTIAL VIRUS GENOME TRANSCRIPTION%REACTOME%R-HSA-9828642.1 Respiratory syncytial virus genome transcription 3312 REGULATION OF CDH1 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 95%9764265 Regulation of CDH1 Expression and Function 23478 60559 2146 5045 28972 5046 90701 5928 1785 283106 9159 5931 27085 8726 288 1488 1487 29954 5925 8970 3728 8331 8337 128312 10585 8334 9314 8335 6597 8370 55766 8968 54971 8341 5594 8342 5595 8347 7764 8348 117581 94239 8345 3013 9839 8340 1495 8338 255626 1500 1508 3021 653604 3018 6615 3017 85236 3014 8349 7841 474382 7088 2060 54145 3065 1650 23028 100128731 1499 6185 6935 6184 23193 8289 58505 821 5589 746 1603 3703 4609 4343 192669 23112 27327 387893 999 26523 6591 4613 3066 116092 192670 27161 3170 7020 94234 57690 23396 93986 9861 6929 55810 23512 6233 687 79872 7750 348262 10009 7316 6714 10213 9743 4193 5706 6938 5707 5708 7414 5709 54737 7291 5700 5701 5702 1520 5704 5705 5682 5683 5684 5685 5686 10399 5717 1514 5718 5719 1460 11047 6667 5315 5713 1459 5714 5690 5691 1457 5692 5693 5694 7311 7979 5695 7490 7314 60436 5687 11171 5688 5689 23411 9789 PEROXISOMAL LIPID METABOLISM%REACTOME%R-HSA-390918.7 Peroxisomal lipid metabolism 10478 55825 122970 3295 26063 11001 91452 1962 10005 51179 8310 1384 79777 55289 26061 5264 54677 23600 283927 30 215 8309 390916 DEFECTIVE CBLIF CAUSES IFD%REACTOME%R-HSA-3359457.4 Defective CBLIF causes IFD 2694 INTERLEUKIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 95%9020702 Interleukin-1 signaling 6885 7186 7189 79155 7157 7335 10454 64127 8945 3552 11213 3553 5970 841 54472 7334 7850 4215 3557 8517 3146 57162 5604 84166 1147 6285 6288 92610 6283 51135 9684 4793 28512 57161 79671 3551 177 8878 4615 121457 246330 28511 3656 257397 23118 1326 80216 6416 9861 6233 8767 3654 9978 7316 10213 4791 5608 5706 5707 5708 5709 5700 5701 5702 9097 5704 5705 5682 23291 5683 5684 5685 5686 5717 5718 5719 11274 11047 5713 5714 5690 5691 5692 5693 4792 5694 10392 7311 7979 5695 7314 351 4790 8454 5687 5688 5689 6500 3554 CHOLINE CATABOLISM%REACTOME%R-HSA-6798163.6 Choline catabolism 635 23446 501 55349 29958 1757 DEFECTS OF FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME%R-HSA-9651496.5 Defects of Formation of Fibrin Clot (Clotting Cascade) 2147 2158 7450 2161 2811 2160 2812 2157 3818 8459 8460 2815 710 2814 2677 2159 PERK REGULATES GENE EXPRESSION%REACTOME%R-HSA-381042.3 PERK regulates gene expression 51010 167227 6347 51013 118460 8894 3309 1054 1051 22894 440 1965 467 468 56915 1968 1649 3576 9451 4800 11340 4801 8570 4802 23404 9709 54512 22926 5393 23016 3484 5073 CASP5-MEDIATED SUBSTRATE CLEAVAGE%REACTOME DATABASE ID RELEASE 95%9960525 CASP5-mediated substrate cleavage 3606 3553 836 838 79792 SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME%R-HSA-209931.3 Serotonin and melatonin biosynthesis 1644 15 121278 7166 438 TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME%R-HSA-5578749.8 Transcriptional regulation by small RNAs 474382 54145 5434 5435 5436 5437 5438 5439 5430 5431 5432 5433 8970 8331 8337 128312 8334 8335 8370 27327 55766 10526 8968 26523 27161 8341 8342 5901 8347 8348 94239 8345 3013 8340 8338 255626 3021 653604 3018 5440 3017 85236 5441 3014 8349 NADE MODULATES DEATH SIGNALLING%REACTOME DATABASE ID RELEASE 95%205025 NADE modulates death signalling 27018 4803 4804 7531 835 836 DEFECTIVE SLC7A7 CAUSES LYSINURIC PROTEIN INTOLERANCE (LPI)%REACTOME DATABASE ID RELEASE 95%5660862 Defective SLC7A7 causes lysinuric protein intolerance (LPI) 9056 6520 SELENOCYSTEINE SYNTHESIS%REACTOME DATABASE ID RELEASE 95%2408557 Selenocysteine synthesis 6233 6152 6155 6154 6157 9349 6156 6159 6158 23521 51121 6175 11224 6164 200916 6166 6122 6165 6124 6168 6123 6167 118672 6169 6125 116832 25873 22928 6160 6161 51091 140801 4736 6130 6133 9045 6301 6230 6232 6132 6210 6176 6231 60678 6135 6234 6134 6235 6137 6191 6136 2197 6193 79048 6171 6192 6170 6194 6173 51065 6128 140032 6129 6205 6142 6227 6141 6204 6144 6207 6143 6229 6146 6206 6147 6228 6181 6139 6209 6138 6208 6188 7311 6187 6223 6201 6189 6222 6203 6224 6202 6218 6217 3921 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%R-HSA-1482883.5 Acyl chain remodeling of DAG and TAG 57104 347516 84649 80339 11343 8694 158835 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 95%196741 Cobalamin (Cbl, vitamin B12) transport and metabolism 2694 1504 326625 27249 4036 25974 4594 166785 51293 6948 6947 5826 26119 440387 4552 55788 5644 81693 8029 5646 4548 4363 NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 95%5654726 Negative regulation of FGFR1 signaling 673 2251 8074 867 2249 3730 2248 2247 2246 10253 8569 5781 27006 2255 5515 7311 5516 7314 5518 5594 5595 6233 10818 7316 26281 2254 SIGNALING BY MET%REACTOME DATABASE ID RELEASE 95%6806834 Signaling by MET 9101 6456 4233 6455 2060 6457 5906 5908 10254 8027 5879 1399 5295 3673 3688 5770 23163 5290 57610 382 26018 6233 1398 7316 6714 3913 3914 3915 10319 3918 284217 3908 3909 3910 867 3911 3912 6692 3249 10653 5867 10048 9146 3083 5795 5781 85440 53916 4893 3082 200958 5771 2549 2889 7311 84951 64759 7314 3675 5747 6774 6654 30011 3265 DEFECTIVE CYP27A1 CAUSES CTX%REACTOME DATABASE ID RELEASE 95%5578996 Defective CYP27A1 causes CTX 1593 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 95%111885 Opioid Signalling 113 114 5332 115 2774 107 108 55970 109 196883 5566 5567 5568 54331 2767 3710 59345 5443 5153 346562 5519 2769 2782 5321 5515 2776 5516 808 5518 5580 10681 5136 4988 5173 815 5528 2771 5578 2770 3708 3709 816 817 818 2773 1020 5499 2793 2792 5533 5573 5575 2791 5576 5577 5582 2790 5613 156 3838 5137 2788 5534 10645 10768 2787 26960 2786 84254 2785 84152 814 2784 5594 2783 5330 51764 5331 5530 5141 5143 5532 5144 23236 9630 94235 111 112 DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME DATABASE ID RELEASE 95%5654687 Downstream signaling of activated FGFR1 27006 2255 2251 8074 5335 2549 2249 2248 2247 10818 2246 10817 23768 23769 5295 26281 5781 6654 23767 4893 5290 2254 3265 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%1483206 Glycerophospholipid biosynthesis 56910 117245 54979 10162 85465 2819 126969 9468 201164 26279 55326 10809 81579 56894 56895 158835 22925 79887 56261 1103 57110 204962 79888 5321 27132 1120 255189 283871 8398 114971 8399 55224 5833 9489 1119 255043 100137049 9362 149998 10400 283748 5320 3032 3030 84803 79143 122618 154141 81490 57153 137964 114884 84879 80339 5337 58488 5338 50640 8904 151056 114879 114882 123745 84895 23446 5920 57678 51365 253558 254531 5322 80821 55500 5319 9663 8694 55750 84649 2820 6901 9926 129642 11343 64900 23760 23761 23646 54675 150763 23175 8605 23659 8443 80736 56994 10554 5130 8760 171586 9600 1040 57605 83394 10423 8895 590 200879 63874 64600 23171 57104 248 30814 64850 1460 1459 1457 54947 43 374986 162466 347516 51205 11145 9791 23259 10555 50487 10390 LXRS REGULATE GENE EXPRESSION TO LIMIT CHOLESTEROL UPTAKE%REACTOME DATABASE ID RELEASE 95%9031525 LXRs regulate gene expression to limit cholesterol uptake 29116 7376 6256 10062 6257 REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME DATABASE ID RELEASE 95%6804759 Regulation of TP53 Activity through Association with Co-factors 54971 8626 7159 207 51230 25946 23368 208 7161 10000 5457 10848 5458 7157 ABERRANT REGULATION OF MITOTIC CELL CYCLE DUE TO RB1 DEFECTS%REACTOME DATABASE ID RELEASE 95%9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 8881 64682 25906 11065 8697 7324 10393 7027 29945 1021 595 27338 1019 119504 29882 1017 894 896 1871 246184 1026 898 996 1870 51343 51434 6502 51433 9134 1028 1027 7029 1869 5925 51529 7321 FGFR2 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 95%1839126 FGFR2 mutant receptor activation 2252 2251 8074 2963 2962 2249 5434 5435 2248 5436 2247 5437 5438 2246 5439 2263 22916 5430 4686 5431 5432 5433 8823 27006 2255 8817 26281 5440 5441 2254 DAP12 SIGNALING%REACTOME DATABASE ID RELEASE 95%2424491 DAP12 signaling 5335 7305 9402 3937 5879 5295 5296 2534 567 6850 4893 3932 5290 5291 54209 3133 22914 3822 3824 10451 7410 695 6654 5336 3265 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%R-HSA-975110.5 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling 51135 7335 54106 3665 7334 51284 4615 7189 3654 MPS II - HUNTER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206296.5 MPS II - Hunter syndrome (HS-GAG degradation) 3423 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 95%193704 p75 NTR receptor-mediated signalling 83464 29 8874 51107 64857 572 3065 57449 4803 389337 445328 2245 23263 3551 50650 8878 4615 26574 221472 6610 5599 9639 10672 10276 55701 5879 9459 9138 11108 4168 6868 27018 27237 7074 6655 11214 8841 5924 4099 57142 4974 7189 84894 3066 6233 8767 3654 7316 5584 5970 396 835 7204 9500 55160 4792 23365 9181 7311 128272 57580 7314 4804 7531 4790 10018 26230 121512 1894 10451 23421 7410 84904 100271715 26084 23370 25791 89846 9826 54848 9828 7409 387 836 23229 22899 5663 50649 6654 8997 23385 55851 6453 5664 7984 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 95%163210 Formation of ATP by chemiosmotic coupling 516 517 10632 518 84833 521 522 509 27109 506 4508 9551 498 4509 539 513 10476 9556 514 515 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME%R-HSA-975155.6 MyD88 dependent cascade initiated on endosome 6885 7186 7189 79155 7157 7335 3665 10454 64127 929 8945 5970 353376 841 7334 148022 8517 3146 23643 5594 5595 1386 7099 57162 5604 5598 51231 1849 84166 1147 1848 6285 1846 6288 1845 92610 6283 51295 51135 4214 9684 4793 28512 57161 79671 3551 177 4615 121457 246330 5599 28511 3656 257397 23118 1326 5609 466 80216 6416 4208 5601 7867 5602 5606 5519 54106 5515 5516 5518 6233 8767 3654 9261 7316 5528 4791 5608 9097 23291 11274 1432 4792 10392 7311 6197 7314 6196 351 4790 9252 6195 8454 4205 2353 5600 2002 6500 3725 51284 TIE2 SIGNALING%REACTOME DATABASE ID RELEASE 95%210993 Tie2 Signaling 7010 284 285 2886 2888 9046 5295 5296 51378 6464 5781 6654 4893 5290 5291 3265 BINDING AND ENTRY OF HIV VIRION%REACTOME DATABASE ID RELEASE 95%173107 Binding and entry of HIV virion 7852 920 5478 1234 LAGGING STRAND SYNTHESIS%REACTOME%R-HSA-69186.4 Lagging Strand Synthesis 23649 5422 5557 5558 5111 10714 5424 5425 5981 57804 3978 1763 5982 2237 6117 5984 5983 5985 6119 6118 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME%R-HSA-69017.4 CDK-mediated phosphorylation and removal of Cdc6 1017 9861 6233 7316 10213 51529 7321 5706 8881 64682 5707 25906 5708 11065 8697 5709 7324 10393 29945 27338 119504 5700 5701 29882 5702 246184 898 996 5704 51343 51434 5705 51433 5682 5683 9134 5684 5685 5686 5717 5718 5719 11047 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 5687 5688 5689 990 890 8900 CARGO CONCENTRATION IN THE ER%REACTOME DATABASE ID RELEASE 95%5694530 Cargo concentration in the ER 81562 149111 4253 375056 2348 10175 10802 1522 3998 1075 10484 90411 79748 374 10960 10959 5265 2153 10113 9554 9570 2890 7039 6811 9871 9632 1294 51128 10972 10427 2157 966 254263 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-HSA-975956.2 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 6233 6152 6155 6154 6157 9349 6156 6159 6158 23521 51121 6175 11224 6164 200916 2107 6166 6122 6165 6124 23708 6168 2935 6123 6167 6169 6125 116832 1981 25873 6160 6161 140801 4736 6130 6133 22916 9045 6230 6232 6132 4686 6210 6176 6231 6135 6234 6134 6235 5976 6137 6191 6136 2197 6193 6171 6192 6170 6194 6173 51065 6128 140032 6129 6205 6142 6227 6141 6204 6144 6207 6143 6229 6146 6206 6147 6228 6181 6139 6209 6138 6208 6188 7311 6187 6223 6201 6189 26986 6222 6203 6224 6202 6218 6217 3921 SIGNALING BY ERBB2 ECD MUTANTS%REACTOME DATABASE ID RELEASE 95%9665348 Signaling by ERBB2 ECD mutants 11140 3320 2064 1950 5335 55914 2549 1956 5295 6464 6654 4893 5290 3265 REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN INVASION%REACTOME%R-HSA-9854909.3 Regulation of MITF-M dependent genes involved in invasion 1729 634 2766 DRUG RESISTANCE OF KIT MUTANTS%REACTOME DATABASE ID RELEASE 95%9669937 Drug resistance of KIT mutants 3815 PREVENTION OF PHAGOSOMAL-LYSOSOMAL FUSION%REACTOME%R-HSA-9636383.4 Prevention of phagosomal-lysosomal fusion 5868 7316 7311 7314 7879 9146 6233 11151 26276 LOSS-OF-FUNCTION MUTATIONS IN BCKDHA OR BCKDHB CAUSE MSUD%REACTOME DATABASE ID RELEASE 95%9865125 Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD 594 1629 593 ESTROGEN BIOSYNTHESIS%REACTOME%R-HSA-193144.8 Estrogen biosynthesis 441282 1588 3294 51171 3292 51170 SIGNALING BY KIT IN DISEASE%REACTOME%R-HSA-9669938.5 Signaling by KIT in disease 8503 6776 3815 4067 6774 5295 5296 6772 7525 2534 6654 4893 5290 3932 6777 3265 3717 DRUG RESISTANCE OF ALK MUTANTS%REACTOME%R-HSA-9700649.4 Drug resistance of ALK mutants 238 LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME DATABASE ID RELEASE 95%418889 Ligand-independent caspase activation via DCC 23604 9500 90249 26060 1613 1612 842 836 1630 219699 TRKA ACTIVATION BY NGF%REACTOME DATABASE ID RELEASE 95%187042 TRKA activation by NGF 4803 4914 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH PMS2%REACTOME DATABASE ID RELEASE 95%5632987 Defective Mismatch Repair Associated With PMS2 4292 5395 FLT3 SIGNALING IN DISEASE%REACTOME%R-HSA-9682385.3 FLT3 signaling in disease 2120 867 6776 9321 399687 1026 2323 2322 5295 5781 598 4893 5290 9846 5292 7311 2804 7314 6233 7750 50507 2885 7316 6711 6654 6777 3265 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 95%2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) 57834 2678 4048 2687 8529 64174 1800 1580 240 241 9261 246 11283 22949 284541 4051 4363 4056 126410 1579 RHO GTPASES ACTIVATE CIT%REACTOME%R-HSA-5625900.4 RHO GTPases activate CIT 9055 11113 4660 10398 1742 9928 5879 4628 79784 4629 1027 5500 103910 4659 387 4637 4627 388 389 CASP4-MEDIATED SUBSTRATE CLEAVAGE%REACTOME DATABASE ID RELEASE 95%9960519 CASP4-mediated substrate cleavage 3606 3553 836 837 79792 GLYCOSPHINGOLIPID TRANSPORT%REACTOME%R-HSA-9845576.2 Glycosphingolipid transport 83850 51228 80772 23344 1201 84725 57488 375 CELL RECRUITMENT (PRO-INFLAMMATORY RESPONSE)%REACTOME DATABASE ID RELEASE 95%9664424 Cell recruitment (pro-inflammatory response) 718 1511 3552 3553 5025 5970 3326 7295 114548 834 5027 29108 10628 4790 4210 10910 4907 953 957 9051 3606 719 3162 4791 79792 SLC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619102.9 SLC transporter disorders 553 554 6566 9152 682 6557 6559 9843 28234 81031 6569 1836 6584 10568 6578 283652 348995 9883 6396 6528 129401 9688 6575 57122 23225 4927 23165 8021 55746 55706 3098 23636 9187 9631 7175 9972 11097 23279 8086 23511 53371 8480 79023 79902 10762 551 5903 54716 23443 10479 285195 55343 10999 10559 340024 7355 6505 6507 6005 6521 9056 9990 153201 6520 9197 6513 60482 6514 26503 116085 55315 8671 6531 6530 11254 142680 123041 1356 11136 6519 6524 6523 10599 246213 5172 55630 5002 56606 4891 2646 30061 2645 1811 552 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%R-HSA-202427.8 Phosphorylation of CD3 and TCR zeta chains 3123 3122 3120 3119 55824 3118 1445 3117 5795 3115 3113 915 5788 916 920 917 3127 3126 3125 3932 26191 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%R-HSA-193670.2 p75NTR negatively regulates cell cycle via SC1 11108 3065 4803 3066 4804 8841 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%R-HSA-350054.5 Notch-HLH transcription pathway 3065 83933 10013 10014 6907 79718 9734 51564 9612 8841 9794 9611 2648 1387 3516 3066 9759 84441 8850 10046 79885 4851 4853 55869 4854 4855 22938 55534 SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 95%1614517 Sulfide oxidation to sulfate 100131187 1468 6821 7263 23474 58472 DENGUE VIRUS-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 95%9918481 Dengue Virus-Host Interactions 4904 10914 10594 10236 721 11325 55749 335 27238 10921 11338 29894 6430 6432 6431 1660 8175 23524 55763 1655 8729 10450 6427 6426 6429 57703 6428 712 1191 8189 51729 5356 716 27339 9641 1665 84991 722 3181 725 3188 3187 3185 3184 2521 7448 9716 51503 10421 3192 285755 3191 11100 3190 1993 9295 550 83443 7307 10949 22863 10015 2194 23643 7099 3178 23601 3326 1499 23352 5824 6383 221914 9672 10082 6385 57521 2262 6382 55615 2239 2719 7329 2817 64223 57506 2475 3312 5440 8678 5441 4318 2963 6993 2962 5434 5435 5436 5437 5438 5439 5430 5431 5432 4751 5433 80273 1994 4792 317772 85235 79109 7706 7431 10250 27316 3183 79869 115004 340061 221613 29959 92815 8969 440689 253260 3320 8737 64135 1616 1654 8970 8331 8337 6141 128312 8334 8335 8370 8968 23168 8341 8342 8347 79577 8348 30849 8345 51639 3013 80349 53938 123169 8340 8896 9646 81608 8338 10898 255626 23283 54623 51645 653604 3018 3017 5289 85236 24148 6886 55696 8349 55339 1479 4793 1478 1477 375790 23020 85313 10992 9879 9410 8683 3339 10084 11051 57551 9775 5725 10523 9785 10291 10978 4153 199746 53981 9416 8449 9382 10181 8106 51692 815 57794 816 10189 4670 817 22938 818 51340 51585 22826 22827 10283 8241 5093 5094 22916 51593 23350 4686 10286 10285 988 9343 6632 57461 84844 56259 2147 51362 6627 6629 7082 6628 220988 10262 10946 23450 23451 54883 6634 56949 6633 6636 5546 6635 6638 54463 6637 10907 6773 MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME DATABASE ID RELEASE 95%68881 Mitotic Metaphase Anaphase Transition 5347 26271 INTEGRATION OF ENERGY METABOLISM%REACTOME%R-HSA-163685.7 Integration of energy metabolism 113 114 115 2864 107 783 108 55970 109 5906 196883 5566 5567 11069 5568 10411 54331 2767 3710 775 59345 2642 773 2641 2769 777 2782 784 2776 10681 2778 3708 3709 8826 7086 4082 2740 6616 1131 5573 5575 5576 5577 47 26251 3630 2194 3790 5330 5331 150 23236 31 152 2182 2181 51085 79602 51094 3745 3747 5563 6794 5565 9495 5519 6804 51422 5515 5516 5518 10554 948 5528 2771 5578 2770 6888 5207 2793 2792 2791 2790 6945 6861 2788 9370 10768 6844 2787 2786 2785 6513 2784 6514 2783 51764 9630 94235 32 776 6833 3767 6812 111 112 9254 ANTIGEN PROCESSING: UB, ATP-INDEPENDENT PROTEASOMAL DEGRADATION%REACTOME DATABASE ID RELEASE 95%9912633 Antigen processing: Ub, ATP-independent proteasomal degradation 5690 5691 5692 5693 5694 5696 5695 5687 5688 5689 5682 5683 5684 5685 5686 5721 5720 5698 5699 EXPRESSION AND TRANSLOCATION OF OLFACTORY RECEPTORS%REACTOME%R-HSA-9752946.3 Expression and translocation of olfactory receptors 81327 81442 132112 393046 8390 8392 122742 26494 401427 26493 26496 401667 401666 282775 122740 401665 26497 81470 81472 282770 341276 122748 127074 341152 256144 127077 283617 120796 81469 119694 119695 120793 282763 81466 81341 343563 119692 387748 344892 79290 79296 135924 79295 26595 26476 284532 125958 442191 26246 442194 26248 442197 81127 26245 284521 135941 26339 26338 135946 26219 135948 26692 402317 26693 26333 26696 26212 81399 26211 81392 388761 343406 26341 8861 9355 56656 120065 121275 120066 283365 390883 390882 390649 124538 390648 283111 4991 4992 4993 442184 442185 442186 79310 79317 284433 341799 219954 219952 121130 79541 79544 121364 125963 125962 4994 79549 4995 283694 121129 219965 130075 219960 390431 390433 442361 390436 390437 390439 341418 79334 341416 79339 219959 219958 219957 219956 283162 138804 65055 138805 283160 138802 138803 390441 390442 390321 390201 390323 390445 390326 390327 144124 254973 144125 79324 283159 219968 127608 219986 219865 219983 219982 390892 219981 401994 401993 401992 285659 81309 79473 81797 390538 7932 219858 219875 219874 219873 219870 390429 79346 79345 26188 81300 26189 219869 347168 26716 286365 283093 283092 347169 138799 390113 134083 391211 392309 150681 338674 338675 340980 283189 219417 219438 219437 219436 26707 219432 219431 338662 126541 403282 403284 127623 254879 283297 255725 219429 219428 284383 126370 390271 219447 390151 391121 390152 441308 390154 390275 441669 390155 390157 390036 390037 390038 441670 158131 138882 138883 138881 23538 390162 219453 390167 390168 347468 219469 1879 219464 338751 391107 391109 338755 254786 254783 10798 390260 390261 219479 390142 219477 162998 390264 391112 390144 390265 391114 219473 390148 79501 286362 390072 390195 390075 390197 390077 219487 390199 392376 390078 390079 219484 219482 392138 127385 143502 119764 119765 143503 81050 390081 390082 390083 390084 26687 119749 402135 26689 219493 81168 81285 392391 81282 392390 504190 390174 390054 26533 256892 390058 26532 390059 26534 26658 26539 26538 26659 26531 343173 390181 390061 343172 343171 343170 390063 441639 390064 389090 390066 390067 26664 343169 390190 81061 390191 403274 127062 403277 403278 127069 127068 127066 403273 127064 120787 119687 81099 119682 26529 441933 127059 26648 120775 120776 119678 119679 390093 392392 403253 441608 403257 391189 26735 128371 26737 8590 128372 391190 196335 346525 391192 391191 391194 391196 403244 391195 128366 128367 128368 128360 119774 119772 26740 403239 346517 79490 81328 120586 256148 81696 81697 8387 8388 8386 8383 81318 79482 81448 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%R-HSA-2206291.5 MPS IIIC - Sanfilippo syndrome C 138050 DEFECTIVE GALNT3 CAUSES HFTC%REACTOME DATABASE ID RELEASE 95%5083625 Defective GALNT3 causes HFTC 727897 10071 94025 2591 143662 140453 4588 118430 4589 283463 394263 4582 4583 4584 4585 4586 200958 56667 DEFECTIVE TBXAS1 CAUSES GHDD%REACTOME DATABASE ID RELEASE 95%5579032 Defective TBXAS1 causes GHDD 6916 INLA-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELLS%REACTOME DATABASE ID RELEASE 95%8876493 InlA-mediated entry of Listeria monocytogenes into host cells 999 7316 1500 7311 6714 7314 79872 6233 1499 ZINC TRANSPORTERS%REACTOME%R-HSA-435354.4 Zinc transporters 7779 23516 64924 169026 27173 7922 283375 7781 7780 64116 55630 29986 57181 25800 29985 LOSS OF PHOSPHORYLATION OF MECP2 AT T308%REACTOME DATABASE ID RELEASE 95%9022535 Loss of phosphorylation of MECP2 at T308 814 808 5566 HEDGEHOG LIGAND BIOGENESIS%REACTOME%R-HSA-5358346.2 Hedgehog ligand biogenesis 10956 84447 6868 2262 9861 6233 7316 10213 5706 5707 5708 57758 85455 5709 5700 5701 5702 3549 5704 5705 5682 5683 5684 5685 5686 7415 5717 5718 5719 27248 11047 5713 5714 51009 5690 5691 5692 6400 5693 5694 7311 7979 5695 7314 5687 5688 5689 55733 6469 5034 50846 147111 MATURATION OF REPLICASE PROTEINS%REACTOME DATABASE ID RELEASE 95%9694301 Maturation of replicase proteins 23479 RAS SIGNALING DOWNSTREAM OF NF1 LOSS-OF-FUNCTION VARIANTS%REACTOME%R-HSA-6802953.3 RAS signaling downstream of NF1 loss-of-function variants 399473 200734 161742 4893 4763 3265 DEFECTIVE SLC5A1 CAUSES CONGENITAL GLUCOSE GALACTOSE MALABSORPTION (GGM)%REACTOME DATABASE ID RELEASE 95%5656364 Defective SLC5A1 causes congenital glucose galactose malabsorption (GGM) 6523 DEFECTIVE CHSY1 CAUSES TPBS%REACTOME DATABASE ID RELEASE 95%3595177 Defective CHSY1 causes TPBS 63827 1634 633 1464 1462 1463 10675 22856 UPTAKE OF DIETARY COBALAMINS INTO ENTEROCYTES%REACTOME%R-HSA-9758881.4 Uptake of dietary cobalamins into enterocytes 5644 2694 1504 81693 6947 5826 8029 5646 440387 55788 ACYL CHAIN REMODELING OF CL%REACTOME%R-HSA-1482798.3 Acyl chain remodeling of CL 3030 5321 6901 253558 8398 3032 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME DATABASE ID RELEASE 95%3656534 Loss of Function of TGFBR1 in Cancer 7046 4087 4088 7048 7040 2280 PROLINE CATABOLISM%REACTOME DATABASE ID RELEASE 95%70688 Proline catabolism 58510 8659 5625 ADENOSINE P1 RECEPTORS%REACTOME DATABASE ID RELEASE 95%417973 Adenosine P1 receptors 135 136 140 134 DEFECTIVE SLC39A4 CAUSES ACRODERMATITIS ENTEROPATHICA, ZINC-DEFICIENCY TYPE (AEZ)%REACTOME%R-HSA-5619088.5 Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) 55630 TOXICITY OF BOTULINUM TOXIN TYPE D (BOTD)%REACTOME DATABASE ID RELEASE 95%5250955 Toxicity of botulinum toxin type D (botD) 6844 22987 9899 6843 9900 SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 95%5683826 Surfactant metabolism 51201 6440 51816 1512 7270 5029 6569 653509 10568 6439 136 2627 729238 5222 6441 1755 221395 135 29080 643834 21 9476 29995 643847 150 10970 152 1439 1438 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 95%1247673 Erythrocytes take up oxygen and release carbon dioxide 760 6005 6521 762 3040 759 358 3043 DEFECTIVE ABCC6 CAUSES PXE%REACTOME DATABASE ID RELEASE 95%5690338 Defective ABCC6 causes PXE 368 ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%111446 Activation of BIM and translocation to mitochondria 8655 10018 5599 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 95%444473 Formyl peptide receptors bind formyl peptides and many other ligands 301 2359 351 2358 6288 2357 50865 REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 95%8941858 Regulation of RUNX3 expression and activity 5706 5707 5708 5709 865 7040 1029 5700 5701 5702 5704 64750 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 2033 5690 5691 5692 5693 5694 7311 57154 7979 5695 7314 9861 6233 5687 5688 5689 7316 6714 864 10213 4193 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME DATABASE ID RELEASE 95%198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 29121 10990 718 4345 10871 10870 7305 3811 3812 27181 353514 114836 117157 2213 946 3820 3821 340205 10219 146894 57823 10859 11024 11027 8778 135250 131450 9437 3105 124599 959 259197 79168 567 926 29992 29990 54210 10225 100132285 89790 9436 4277 114132 51348 54209 11126 11026 11006 342510 339390 81035 100131439 9976 22914 930 100507436 80329 975 79465 3904 79865 933 27036 3824 146722 6614 196500 8519 3903 10288 2209 3695 1525 3386 3385 3384 120425 3383 4267 3107 3106 7087 3688 27180 7412 945 3134 3133 999 3689 3135 3683 915 916 917 3676 6402 2214 126014 909 56253 56654 5817 5819 89858 910 911 912 4068 3803 3804 11314 3805 3806 374383 925 10666 3802 285852 23547 NEURODEGENERATIVE DISEASES%REACTOME DATABASE ID RELEASE 95%8863678 Neurodegenerative Diseases 831 2801 5052 84290 356 4001 823 7531 351 993 824 10018 826 1020 994 995 7001 2309 8851 3725 6648 HIGHLY SODIUM PERMEABLE POSTSYNAPTIC ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME%R-HSA-629587.6 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors 1146 1143 1145 1144 1141 1137 1136 PYRIMIDINE SALVAGE%REACTOME%R-HSA-73614.5 Pyrimidine salvage 7083 1633 8226 7084 7371 83549 54963 978 7378 151531 1890 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME DATABASE ID RELEASE 95%202430 Translocation of ZAP-70 to Immunological synapse 3123 3122 3120 3119 3118 3117 3115 3113 915 916 920 917 3127 3126 3125 3932 7535 26191 INVADOPODIA FORMATION%REACTOME%R-HSA-8941237.3 Invadopodia formation 8751 8038 9644 8728 TLR3-MEDIATED TICAM1-DEPENDENT PROGRAMMED CELL DEATH%REACTOME%R-HSA-9013957.3 TLR3-mediated TICAM1-dependent programmed cell death 8772 11035 8737 7098 841 148022 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%433137 Sodium-coupled sulphate, di- and tri-carboxylate transporters 26266 6561 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%R-HSA-2179392.4 EGFR Transactivation by Gastrin 1956 5578 1839 4314 6654 4893 3265 PHASE 2 - PLATEAU PHASE%REACTOME%R-HSA-5576893.4 Phase 2 - plateau phase 3753 59283 10008 782 783 9992 23704 3784 23630 10142 27092 59285 59284 775 9254 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-HSA-975871.3 MyD88 cascade initiated on plasma membrane 51295 51135 4214 7100 9684 4793 28512 57161 79671 3551 177 4615 121457 81793 246330 5599 28511 3656 257397 6885 23118 1326 5609 466 80216 6416 4208 5601 7867 5602 5606 5519 7186 7189 79155 7157 5515 5516 5518 6233 8767 9261 3654 7335 10454 7316 5528 4791 64127 8945 5608 5970 9097 841 23291 7334 11274 1432 8517 4792 10392 7311 3146 6197 7314 6196 351 5594 4790 5595 9252 8454 6195 1386 4205 2353 5600 57162 2002 5598 6500 5604 3725 51231 1849 84166 1147 1848 6285 1846 6288 1845 92610 6283 CELL-CELL COMMUNICATION%REACTOME%R-HSA-1500931.9 Cell-Cell communication 5928 1785 9069 23562 9080 53842 137075 51208 5010 24146 9073 5931 9071 9076 149461 9074 9075 26285 1366 1365 1364 49861 84552 6251 7016 10686 2316 81 5829 29780 3611 55742 54751 55679 7408 3987 2318 3914 288 1308 3918 3909 5584 6709 29954 10585 283 977 221935 5339 54549 1508 7841 7088 3065 1650 100128731 87 1499 6185 6184 9459 23193 58505 821 5589 746 1603 3703 4609 4343 192669 23112 89 27327 999 26523 6591 4613 192670 116092 27161 7020 3170 94234 57690 23396 93986 9861 6929 55810 6233 687 79872 961 7750 348262 10009 7316 10213 9743 4193 5706 6938 5707 5708 5709 10979 5700 5701 5702 1520 5704 5705 140885 5682 5683 5684 5685 23607 5686 9863 5717 55243 5718 84623 5719 84063 4868 1460 11047 5713 5315 1459 5714 5690 5691 1457 5692 5693 5694 7311 5695 7314 55423 8935 3691 5687 5688 5817 5819 5689 3655 23411 9789 23478 10326 60559 5045 2146 28972 5046 7305 90701 283106 9159 64398 8573 81607 27085 5818 57863 1013 23705 1010 6711 1008 1007 1003 8726 1005 1004 1001 1002 1016 1015 1012 253559 50855 25945 8826 4690 2185 667 1488 1487 7122 50848 5925 8970 3728 8331 56288 8976 8337 5781 128312 8334 9314 8335 6597 8370 55766 54971 8968 8341 8342 5594 8347 5595 28513 8348 2294 7764 117581 94239 80149 8345 56978 3013 9839 8728 8340 6663 1495 64403 8338 27319 80332 255626 8440 1006 1500 3224 3021 3609 653604 6615 3018 1009 3017 85236 3014 8349 474382 54145 2060 1000 23028 6935 8289 5295 5296 3688 5290 5291 387893 84612 3066 88 10207 23512 92359 6714 7414 54737 7291 10399 2533 1514 2534 6667 5777 7490 7979 60436 11171 5747 26508 51129 FORMATION OF HIV-1 ELONGATION COMPLEX CONTAINING HIV-1 TAT%REACTOME%R-HSA-167200.5 Formation of HIV-1 elongation complex containing HIV-1 Tat 2071 2966 6829 2965 2963 2962 2068 5434 5435 5436 5437 5438 5439 2968 8178 2967 22916 404672 25920 5430 4686 5431 51224 5432 6924 5433 7936 902 6827 6749 9150 6917 1025 51497 7469 11198 904 6921 6923 5440 5441 4331 1022 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 95%453276 Regulation of mitotic cell cycle 1017 9212 9861 6233 6790 7316 10213 8945 51529 7321 5706 8881 64682 5707 25906 5708 11065 8697 5709 7324 10393 29945 27338 119504 5700 5701 29882 891 5702 246184 983 996 5704 51343 51434 6502 5705 51433 5347 5682 5683 5684 4751 5685 5686 5717 9184 5718 5925 5719 991 11047 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 8454 5687 5688 5689 4085 8556 890 8900 6500 26271 9232 701 DEFECTIVE SLC24A1 CAUSES CONGENITAL STATIONARY NIGHT BLINDNESS 1D (CSNB1D)%REACTOME%R-HSA-5619077.3 Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D) 9187 DEFECTIVE ALG3 CAUSES CDG-1D%REACTOME%R-HSA-4720475.4 Defective ALG3 causes CDG-1d 10195 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME%R-HSA-392154.3 Nitric oxide stimulates guanylate cyclase 27094 27345 8654 3778 2983 3779 2982 5136 5138 4842 2977 4843 10846 3708 4846 10335 5152 10242 5153 50940 5593 NUCLEOTIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%8956320 Nucleotide biosynthesis 7372 3615 790 3614 1723 122622 5471 5198 10606 158 159 8833 471 2618 SUNITINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702632 sunitinib-resistant FLT3 mutants 2322 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME DATABASE ID RELEASE 95%174437 Removal of the Flap Intermediate from the C-strand 5111 10714 5424 26277 5425 57804 25913 7013 7486 65057 1763 7014 2237 6117 54386 6119 6118 SIGNALING BY LEPTIN%REACTOME DATABASE ID RELEASE 95%2586552 Signaling by Leptin 3952 3667 6776 6774 8660 9021 5781 6777 3717 M-DECAY: DEGRADATION OF MATERNAL MRNAS BY MATERNALLY STORED FACTORS%REACTOME DATABASE ID RELEASE 95%9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 9125 57472 1981 25904 85456 9775 23019 4850 1975 23405 29883 55571 4848 1974 4849 1973 1977 678 9337 27161 246175 26986 54766 390748 10605 CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 95%8856825 Cargo recognition for clathrin-mediated endocytosis 10618 163 554 4074 10254 8027 1601 1175 1173 3949 8218 2873 408 51138 409 1080 9318 143425 7018 338 6572 920 8673 1950 867 1956 1129 9146 6857 8533 64708 9185 950 10987 22848 10980 286749 90019 50813 23208 10920 115548 1856 8322 25977 3267 85021 8301 9856 23149 85439 9892 1839 6453 55707 6456 84251 6455 2060 6457 1861 27348 8674 22905 29988 29978 29979 1212 50618 4036 6233 127833 4738 7316 9341 6845 3482 551 915 917 154 374 156 6844 7311 6869 7314 185 3575 29924 26119 7039 58513 685 1213 1211 255324 2069 7037 157 7474 160 30011 161 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME DATABASE ID RELEASE 95%2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 1557 1545 1544 1543 2053 1559 1573 1558 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%R-HSA-163359.8 Glucagon signaling in metabolic regulation 113 114 115 107 108 55970 109 196883 5566 5567 5568 54331 59345 5573 2642 5575 2791 2641 5576 5577 2790 2788 2782 2787 2786 2785 2784 2783 51764 2778 94235 111 112 CHYLOMICRON REMODELING%REACTOME DATABASE ID RELEASE 95%8963901 Chylomicron remodeling 348 345 335 336 337 4023 338 338328 344 116519 DEFECTIVE UGT1A1 CAUSES HYPERBILIRUBINEMIA%REACTOME%R-HSA-5579002.5 Defective UGT1A1 causes hyperbilirubinemia 54658 REGULATION OF CDH11 MRNA TRANSLATION BY MICRORNAS%REACTOME DATABASE ID RELEASE 95%9759811 Regulation of CDH11 mRNA translation by microRNAs 4343 192669 23112 27327 26523 192670 27161 57690 1009 CELLULAR RESPONSE TO HYPOXIA%REACTOME DATABASE ID RELEASE 95%1234174 Cellular response to hypoxia 25994 10370 405 768 8453 9861 7323 6233 7322 2034 126374 84962 9978 3091 112399 112398 8994 7316 6921 6923 7422 64344 54583 10213 7428 7321 5706 5707 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 1387 11047 5713 5714 2033 5690 5691 5692 5693 5694 7311 7979 5695 7314 5687 5688 2056 5689 55662 DEFECTIVE B4GALT1 CAUSES B4GALT1-CDG (CDG-2D)%REACTOME DATABASE ID RELEASE 95%3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) 176 4958 5549 2683 4060 11081 4969 2331 SEMAXANIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702577 semaxanib-resistant FLT3 mutants 2322 PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF BMAL1 (ARNTL) AND CLOCK%REACTOME%R-HSA-9931529.2 Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK 1457 406 9575 1020 1460 DEFECTIVE ALG9 CAUSES CDG-1L%REACTOME DATABASE ID RELEASE 95%4720454 Defective ALG9 causes CDG-1l 79796 ASSEMBLY AND RELEASE OF RESPIRATORY SYNCYTIAL VIRUS (RSV) VIRIONS%REACTOME%R-HSA-9820962.1 Assembly and release of respiratory syncytial virus (RSV) virions 3320 3326 GSD 0%REACTOME DATABASE ID RELEASE 95%3858516 GSD 0 8908 2998 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 95%1280215 Cytokine Signaling in Immune system 5611 3977 1435 8792 4312 4055 4843 8742 4313 4050 2208 1399 115650 51330 959 3636 1398 2688 9655 3660 79792 3659 1154 3552 2339 5743 4869 3553 5970 6616 841 3837 5780 5782 5784 8809 54472 5778 8807 7850 7334 3562 4215 3559 84867 26095 3558 11141 3557 3565 27178 10068 5771 3596 26469 25930 3146 103 3569 10018 1386 3606 57162 4502 5598 7409 51231 1849 1848 1846 1845 3306 3305 3839 2633 402569 8651 3840 3459 3841 3460 3551 5300 8878 4615 5599 5775 4208 6655 821 7341 6382 3684 7329 7323 960 7322 8767 57506 2357 9978 2289 3091 4067 3635 3689 6921 6923 7006 6175 9987 6648 9049 6775 8678 9446 4507 375 3716 3936 654483 3313 4318 5478 6647 5898 4088 6845 6888 7297 4282 5055 9097 3595 240 3594 6657 3593 3592 5795 1072 246 3434 27250 4600 302 1265 9470 2317 3586 4092 5721 1982 4478 8672 6950 317649 2939 5306 5495 829 4599 11274 3838 4792 10392 5293 23586 3663 6197 6196 9252 6195 4205 684 7525 7706 60 5371 6885 6868 4170 7187 7186 7189 7157 79155 7133 356 9451 8877 2919 50616 348995 9883 2625 6396 941 129401 942 9688 10454 57122 23225 3836 64127 4927 23165 55746 55706 23636 4690 9631 5783 7175 9972 11097 329 23279 8086 23511 53371 8480 79023 79902 10762 2185 64135 5903 330 3608 5781 4893 8503 998 8517 8660 5594 5595 208 54014 3609 1147 6654 3265 6351 6352 378708 51447 6356 6097 6348 6347 3662 6349 2887 2247 6095 6364 2323 6935 6363 8563 2322 6367 1230 9775 5295 3688 5296 5770 6464 5519 332 5290 5291 2920 9846 3576 3667 71 5515 5516 3845 5518 58480 3627 5451 1437 1436 5525 815 1234 5528 6714 7422 816 4791 817 818 7321 3717 3561 3929 3587 6776 7324 9402 3123 3122 3120 3119 983 3118 1445 3117 3115 3113 23291 5724 4692 3127 10538 3126 3598 3125 3597 2534 6850 6624 79923 3055 9180 149233 3932 133396 4985 200081 3082 51561 6809 3566 27189 3976 1489 5008 58985 132014 6627 3574 3572 1271 7979 1270 3575 351 3590 3589 4314 8454 3588 85480 10148 64109 23529 163702 55540 2162 29949 116379 53833 53832 55801 6500 282617 282618 5034 11009 282616 3718 3554 246778 5336 9466 50604 6773 9244 4904 386653 7076 3603 29760 1440 64806 301 5894 3454 5908 5566 6810 6813 3309 759 1660 1958 8575 5657 6895 729230 9616 5292 115361 7318 2635 115362 2634 5229 10019 8835 9306 6503 84174 2316 7335 199990 55120 3665 2189 920 91442 80233 2175 2188 2187 57697 3181 2178 8945 3185 2335 1901 1511 59307 11213 3911 3934 5896 5897 2209 146433 139716 8771 128178 8995 970 3383 54920 595 1896 10913 3107 4049 10673 939 1026 3106 8740 8600 8744 4982 7293 8894 7292 3604 60401 23495 943 944 201626 9966 6041 1965 8718 4938 608 4940 8638 2308 7412 9020 1968 4609 6804 5971 3134 3133 1977 163351 7132 5580 9861 6233 3654 9261 9246 4988 3312 7316 3162 5803 10213 8741 7534 8021 5608 5062 5706 3135 5707 5708 5709 5696 1981 207 5700 5701 5702 5704 5705 9235 5682 5683 5684 5685 5686 5717 5718 834 5719 1432 11047 201254 5713 27 5714 5690 5691 9039 6844 5692 5693 5694 8065 604 7311 2889 5695 7314 4790 9040 3304 3458 1278 5687 5688 5600 5689 51191 836 5045 90865 7040 9173 4001 7431 8808 27179 27177 56300 3105 6772 5443 26525 567 84639 6622 2176 5617 3661 29110 7184 6737 3563 8519 59067 4734 3560 3581 84868 2885 3578 1439 50615 1438 3568 3601 3567 3600 6777 3965 2342 3320 81603 10410 5335 2690 867 55223 2689 91543 3430 3664 3669 3429 5618 10612 3437 55128 3433 10964 117854 1027 23321 51127 10379 6059 7726 4582 85363 10475 3394 6672 4261 10581 9830 23650 7124 10107 6597 10346 10437 1974 25939 1973 1052 4281 8968 24138 6778 79097 11074 53840 54739 80128 80263 23087 8784 388646 2537 3570 1442 4684 6774 5604 653604 84166 6285 6288 92610 6283 51135 9684 4793 28512 57161 1441 79671 3687 177 121457 246330 28511 3656 257397 23118 1326 5609 466 80216 6416 5601 7867 5602 5606 84818 3442 3441 25820 3440 5610 23765 8554 3452 3451 3449 3448 3447 4939 948 3446 3445 3444 3443 3456 2810 9636 3605 112744 7291 596 598 8764 5777 9021 2353 4128 3726 2002 10000 22926 2309 3725 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME DATABASE ID RELEASE 95%3304351 Signaling by TGF-beta Receptor Complex in Cancer 7046 4087 4088 7048 7040 4089 2280 DEFECTIVE CUBN CAUSES MGA1%REACTOME%R-HSA-3359463.4 Defective CUBN causes MGA1 2694 81693 8029 HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME%R-HSA-5685938.3 HDR through Single Strand Annealing (SSA) 7486 2072 5982 5883 5884 5983 116028 3364 472 672 5893 84126 83990 144715 83695 5810 2067 10111 5932 4361 7156 9156 4683 11073 580 10524 641 1763 545 6117 5984 5985 6119 5888 25 6118 80010 TRANSLATION OF STRUCTURAL PROTEINS%REACTOME%R-HSA-9683701.6 Translation of Structural Proteins 7841 6480 256435 27090 4245 23193 821 5589 7341 143 2931 7311 56965 7329 83666 7314 84875 79668 54956 54625 6233 2932 7316 10610 6483 6482 6484 2589 6487 RND2 GTPASE CYCLE%REACTOME%R-HSA-9696270.2 RND2 GTPase cycle 5783 1969 2802 667 27316 1828 10817 9928 9352 81839 157285 5295 5296 9231 8502 8153 56667 23048 224 11180 22852 55227 91544 857 11188 10818 23513 55789 57498 10726 10970 23074 7037 7126 2909 23592 392 23129 3895 394 222584 57216 253980 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 95%420597 Nectin Necl trans heterodimerization 5819 81607 5818 57863 23705 5817 25945 REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME%R-HSA-6804756.4 Regulation of TP53 Activity through Phosphorylation 83860 6872 5300 9891 6874 1017 6873 6881 5562 6908 5563 6794 5564 5565 6880 6883 6882 6884 129685 7157 51422 6875 6878 6877 5571 6879 9212 6233 6790 53632 7316 112858 11200 4194 26155 4193 22974 8148 8445 51616 1263 1020 138474 7486 54457 5982 5883 5884 5983 6749 8851 116028 3364 204851 472 672 1432 11198 1460 84126 1111 83990 1459 144715 83695 5810 1457 10111 5932 7311 94241 4361 7314 7156 9156 4683 11073 580 5600 10524 641 1763 545 6117 5984 5985 890 6119 8900 6118 80010 28996 8550 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%R-HSA-917977.3 Transferrin endocytosis and recycling 127124 7036 23545 51382 79689 533 534 55240 535 537 10312 50617 9296 245972 245973 155066 9114 51606 7018 3077 9550 523 525 526 527 7037 57192 528 529 8992 90423 ENDOGENOUS STEROLS%REACTOME%R-HSA-211976.8 Endogenous sterols 57491 1545 10858 1583 1582 1581 1584 8648 405 196 10499 5443 51302 1593 1589 1595 285440 1588 1585 9971 9420 6256 9915 2232 112812 2230 RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME%R-HSA-5666185.2 RHO GTPases Activate Rhotekin and Rhophilins 30851 114822 64130 387 388 85415 389 54763 6242 DEFECTIVE HEXA CAUSES GM2-GANGLIOSIDOSIS 1%REACTOME DATABASE ID RELEASE 95%3656234 Defective HEXA causes GM2-gangliosidosis 1 3073 POSITIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME%R-HSA-9764790.1 Positive Regulation of CDH1 Gene Transcription 8289 3170 7020 5925 93986 55810 687 11171 9314 6667 9839 INTERLEUKIN-17 SIGNALING%REACTOME DATABASE ID RELEASE 95%448424 Interleukin-17 signaling 64806 3551 5599 3656 257397 6885 23118 1326 5609 466 6416 4208 5601 7867 5602 5606 84818 5519 7189 79155 23765 5515 5516 5518 6233 8767 9261 3654 7335 10454 7316 5528 3605 64127 112744 8945 5608 23291 7334 1432 27189 8517 132014 10392 7311 6197 7314 6196 5594 4790 5595 9252 8454 6195 1386 4205 2353 5600 55540 2002 5598 6500 5604 3725 51231 1849 1147 1848 1846 1845 INSULIN-LIKE GROWTH FACTOR-2 MRNA BINDING PROTEINS (IGF2BPS IMPS VICKZS) BIND RNA%REACTOME%R-HSA-428359.5 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs IMPs VICKZs) bind RNA 10644 10643 10642 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME DATABASE ID RELEASE 95%192105 Synthesis of bile acids and bile salts 10858 1646 1645 6718 9023 1582 3295 1581 8648 10499 8644 80270 26031 9885 570 114876 51302 1593 8309 114880 8647 114881 114883 1109 10998 11001 9971 9420 10005 6256 5007 23600 SEPARATION OF SISTER CHROMATIDS%REACTOME DATABASE ID RELEASE 95%2467813 Separation of Sister Chromatids 348995 6396 57122 55746 23279 79023 79902 5903 54908 6232 8655 25909 8379 9183 1063 1062 9184 1060 991 151648 8243 55166 9126 23244 23047 1058 79019 10735 151246 23063 9735 5885 10274 23332 79003 55055 81565 22919 348235 5048 23421 220134 57082 57405 51143 147841 4085 64105 401541 10403 54820 80776 701 54821 378708 1781 23122 1780 79172 1778 81930 55920 84643 3796 9793 91687 57551 79682 5905 1783 5501 83540 80152 2491 5519 332 55143 699 11243 3619 140735 5515 11004 5516 5518 9212 9861 25936 6233 11130 64946 79980 10726 5525 5526 55839 5527 7316 5528 7514 5529 10213 51529 7321 5706 8881 64682 5707 25906 5708 11065 5709 8697 7324 10393 29945 27338 119504 5700 5701 29882 5702 246184 996 5704 51434 5705 51433 5682 5347 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 5687 113130 5688 5689 9700 6249 9232 STIMULATION OF THE CELL DEATH RESPONSE BY PAK-2P34%REACTOME DATABASE ID RELEASE 95%211736 Stimulation of the cell death response by PAK-2p34 836 5062 DEFECTIVE SLC2A9 CAUSES HYPOURICEMIA RENAL 2 (RHUC2)%REACTOME DATABASE ID RELEASE 95%5619047 Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) 56606 FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME DATABASE ID RELEASE 95%77042 Formation of editosomes by ADAR proteins 103 104 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME DATABASE ID RELEASE 95%2428928 IRS-related events triggered by IGF1R 2252 2251 8074 2249 2248 2247 57761 2246 2323 2322 152831 8823 5295 5296 5140 2264 5781 4893 5290 5291 5170 27006 2255 117145 9846 54106 3667 2549 3481 8660 3479 30849 10818 8471 3480 208 8817 26281 9965 5289 6654 2254 3265 DIFFERENTIATION OF KERATINOCYTES IN INTERFOLLICULAR EPIDERMIS IN MAMMALIAN SKIN%REACTOME%R-HSA-9725554.2 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin 1950 MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 95%8874081 MET activates PTK2 signaling 3918 284217 3908 4233 3909 3910 3911 3912 3675 5747 3673 6714 3688 3913 3914 3915 3082 10319 AMINE OXIDASE REACTIONS%REACTOME%R-HSA-140179.4 Amine Oxidase reactions 4128 4129 196743 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA2 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 7486 5982 5883 5884 5983 116028 3364 472 10635 672 675 84126 83990 144715 83695 5810 7516 10111 5932 7979 4361 7156 5890 9156 5892 4683 11073 580 10524 641 1763 545 6117 5984 5985 6119 79728 5888 6118 80010 5889 GASTRULATION%REACTOME DATABASE ID RELEASE 95%9758941 Gastrulation 387332 7849 344022 5081 2043 9241 4487 7546 130497 3516 8928 8850 55534 5453 25925 5015 6656 2253 6911 2637 3549 89780 64321 9794 5460 2648 8463 2033 5076 4602 84667 343930 2296 652 134701 145873 84441 10683 2294 2303 3169 9839 145258 83881 10046 4851 6469 6615 5077 2249 83439 2247 1499 51176 6932 7004 6934 10413 7022 7021 999 3170 7020 9861 7852 51592 10213 22938 5706 5707 5708 5709 4087 4088 4089 5700 5701 5702 6657 5704 5705 5682 1749 5683 5684 5685 5686 5717 5718 5719 7545 79923 11047 1387 5713 2627 5714 8320 5690 6862 5691 28514 5692 5693 5694 3975 7979 5695 3955 5687 5688 2626 5689 2260 5080 MHC CLASS II ANTIGEN PRESENTATION%REACTOME DATABASE ID RELEASE 95%2132295 MHC class II antigen presentation 163 6712 11127 1759 10053 8907 8905 1175 130340 1173 1174 162 1785 164 22872 26052 9871 9632 832 6396 10427 1512 8655 5641 1062 114876 9493 10437 10112 1510 1519 1509 8722 51143 83547 3112 55860 3111 24137 1508 51164 3902 3109 830 3108 26153 10671 1639 93661 22920 84516 6456 1781 1780 1778 81930 84643 3796 972 1783 821 9371 140735 11004 3798 3799 3797 3832 3835 64837 89953 285643 147700 5476 375 3831 3123 3122 3120 7879 3119 3118 10802 3117 1520 3115 3113 1075 10540 10484 56992 3127 1514 3126 3125 829 1513 1515 10120 29127 10121 11258 1213 1211 51128 160 161 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME%R-HSA-435368.6 Zinc efflux and compartmentalization by the SLC30 family 7779 64924 169026 7781 7780 REGULATION OF PTEN MRNA TRANSLATION%REACTOME%R-HSA-8943723.2 Regulation of PTEN mRNA translation 4343 192669 23112 27327 26523 192670 27161 57690 5728 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%R-HSA-1855204.5 Synthesis of IP3 and IP4 in the cytosol 84812 5332 3705 4952 3706 3707 5335 51196 89869 122618 80271 5728 27124 3636 808 5330 8867 5331 23236 23007 3635 3633 9651 5333 5336 113026 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-83936.4 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 64078 222962 291 3177 292 402 2030 293 9153 9154 23568 55315 HYPUSINYLATION%REACTOME DATABASE ID RELEASE 95%204626 Hypusinylation 83475 1984 56648 1725 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME DATABASE ID RELEASE 95%77350 Beta oxidation of hexanoyl-CoA to butanoyl-CoA 35 3030 1892 3033 3032 CLEAVAGE OF THE DAMAGED PURINE%REACTOME DATABASE ID RELEASE 95%110331 Cleavage of the damaged purine 474382 4350 54145 8970 8331 8337 128312 8334 8335 4968 8370 55766 8341 8342 8347 8290 8348 55247 94239 8345 26277 3013 25913 8340 7013 65057 7014 8338 255626 54386 3018 3017 85236 3014 8349 DEFECTIVE CYP7B1 CAUSES SPG5A AND CBAS3%REACTOME DATABASE ID RELEASE 95%5579013 Defective CYP7B1 causes SPG5A and CBAS3 9420 MEMBRANE TRAFFICKING%REACTOME%R-HSA-199991.8 Membrane Trafficking 10618 554 10052 57165 375519 57369 2702 2701 2700 127534 375056 2709 4074 2707 2706 1759 2705 81846 2703 219770 125111 1601 10804 81025 84694 8218 56894 149371 10959 55763 8729 5321 55770 117177 23265 338 26052 60412 378 54536 8766 79643 51652 966 10640 11336 1604 91782 1121 92421 6709 5864 5867 6857 9146 5868 8533 64708 27243 10987 10980 128866 10971 29082 50813 9685 25978 10920 10113 9570 55860 51164 11015 55738 830 10671 1639 6453 93661 84516 2665 10890 2799 4124 5879 6305 22878 8871 22879 4036 221960 79890 84958 80006 2664 5870 23396 57465 8867 51762 23682 83874 11345 729873 10260 6764 4738 9230 9909 84315 6836 51256 160518 5869 22931 163259 126432 9363 26130 3257 5878 27342 79958 9135 375 201627 338382 125058 163486 54662 201475 55357 1122 5898 57533 6845 11337 11021 3482 79735 57706 5872 23258 79961 26000 1075 116442 60684 23011 10981 5866 84079 154 22898 54453 55667 829 27147 51622 377 4943 259173 89781 23637 9610 156 64786 414918 51112 7532 7531 51552 7533 157 10254 8027 408 10342 409 1080 3092 8546 5049 1362 11031 2804 143425 2697 6811 6572 374403 8398 832 6396 57679 6711 9342 81567 23433 1522 8655 9183 58485 1062 1315 3630 1856 5048 8301 26958 9585 8774 51143 208 8775 27128 23046 24137 57589 10139 26153 143187 55605 636 60592 23299 22920 55850 84316 23256 9322 10945 400 1781 5286 63908 51014 1780 57511 55614 146909 1778 81930 8674 8677 8675 84643 339122 55582 3796 23423 29988 23303 4644 250 372 5873 51542 84342 91949 7110 4121 1783 4122 381 5050 9371 221458 51272 662 1523 57134 547 10244 9648 50618 9527 23647 140735 9267 9265 11004 9266 55083 808 22796 79571 2590 9382 2890 51560 25782 347517 113220 3797 3832 10972 3833 3834 3835 90990 9950 25839 9276 9712 285643 90196 10228 122830 11316 83548 23095 10749 27333 2803 10905 60561 286 60560 10466 9827 9321 22818 22930 6293 2800 1314 10133 124602 915 54732 56992 4218 54734 917 51226 83452 738 53407 64147 27314 22820 55275 51594 4641 11014 9609 5265 2153 185 3575 351 29924 26119 58513 1213 8408 1211 51128 2157 160 30011 161 163 6708 6710 6712 6810 6814 1175 1173 3949 1785 4627 22872 5874 7018 84313 51028 11267 9871 9632 1294 920 57731 10427 287 288 51332 8673 2801 1129 388552 9185 55330 2580 950 22848 286749 10717 90019 8906 112574 1176 23208 6643 115548 23216 54885 152503 84062 23431 8322 23557 25977 9554 3267 85021 286451 9829 9847 57186 9856 9882 23149 85439 51429 9892 134829 64746 1839 157807 6272 273 274 11154 55707 9698 11252 84251 7164 7163 27131 1861 26258 27348 29763 22905 9026 79058 1777 57148 51399 29993 2647 9179 29978 29979 5563 7248 5564 5565 51422 5571 382 6233 127833 53632 7249 3312 8773 7316 5537 79090 22870 7534 11070 9341 9117 11196 254263 81562 1453 27095 149111 9919 89866 7109 4253 6399 207 2348 7879 23243 10175 126003 25956 55014 7529 10802 10652 51693 3998 122553 10540 10484 83696 90411 10282 4012 26984 79748 55291 128637 10960 6844 7311 29127 10121 7314 11258 7037 2589 4952 11127 55048 89853 51534 9525 137492 27183 51271 10053 8907 51160 155382 8905 130340 93343 1174 7251 79720 162 2873 164 51510 51138 23163 9318 4646 2495 26088 23048 2512 54874 23062 81631 26286 1950 867 1956 84364 8976 6517 9493 10112 6456 6455 2060 6457 10226 4905 1212 11311 22836 3798 3799 2017 10109 10552 10093 10092 10094 10097 2810 10096 64837 51209 89953 147700 9367 3831 551 374 81876 5861 7082 6869 64689 7039 685 255324 2069 8615 10000 7474 3-METHYLGLUTACONIC ACIDURIA%REACTOME DATABASE ID RELEASE 95%9914274 3-methylglutaconic aciduria 549 DEFECTIVE MUT CAUSES MMAM%REACTOME DATABASE ID RELEASE 95%3359478 Defective MUT causes MMAM 4594 166785 SARS-COV-1 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME%R-HSA-9735871.2 SARS-CoV-1 targets host intracellular signalling and regulatory pathways 5706 2033 4088 7329 7532 4089 7531 857 7533 7529 2810 7534 6667 5170 10971 FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190377 FGFR2b ligand binding and activation 2255 2252 27006 83888 9982 2248 2247 2246 143282 SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 95%5654743 Signaling by FGFR4 673 2251 8074 5335 867 2249 2247 2246 10817 152831 8823 5295 10253 8569 2264 5781 4893 5290 2549 5515 7311 5516 7314 5518 5594 5595 6233 10818 7316 8817 26281 9965 6654 2254 3265 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%R-HSA-1660517.8 Synthesis of PIPs at the late endosome membrane 4534 5286 8898 9896 9110 30849 5289 200576 9108 66036 55697 TRAFFICKING OF MYRISTOYLATED PROTEINS TO THE CILIUM%REACTOME DATABASE ID RELEASE 95%5624138 Trafficking of myristoylated proteins to the cilium 6102 403 27031 192668 84747 CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 95%5357769 Caspase activation via extrinsic apoptotic signalling pathway 8797 8737 353376 841 90249 26060 1613 1612 1630 7186 148022 9500 355 356 8717 23643 7099 219699 8743 8772 23604 842 836 929 8795 CLEARANCE OF DOPAMINE%REACTOME%R-HSA-379401.6 Clearance of dopamine 4128 220074 1312 6531 REGULATION OF TNFR1 SIGNALING%REACTOME DATABASE ID RELEASE 95%5357905 Regulation of TNFR1 signaling 1540 8737 27005 329 3551 9099 841 10133 330 7185 10399 7375 90268 84888 25999 7186 56928 7124 7128 29110 8517 10273 10616 56957 7311 220213 8717 7132 7314 55072 9825 7323 6233 7322 9261 8772 8408 9641 7332 7316 142678 331 1147 81858 8887 7321 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 95%174143 APC C-mediated degradation of cell cycle proteins 1017 9212 9861 6233 6790 7316 10213 8945 51529 7321 5706 8881 64682 5707 25906 5708 11065 8697 5709 7324 10393 29945 27338 119504 5700 5701 29882 891 5702 246184 983 996 5704 51343 51434 6502 5705 51433 5347 5682 5683 5684 4751 5685 5686 5717 9184 5718 5925 5719 991 11047 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 8454 5687 5688 5689 4085 8556 890 8900 6500 26271 9232 701 NEF MEDIATED DOWNREGULATION OF CD28 CELL SURFACE EXPRESSION%REACTOME DATABASE ID RELEASE 95%164939 Nef mediated downregulation of CD28 cell surface expression 1173 940 REGULATION OF THE APOPTOSOME ACTIVITY%REACTOME DATABASE ID RELEASE 95%9627069 Regulation of the apoptosome activity 22900 55075 57099 51074 331 842 5594 317 5595 54205 56616 SIGNALING BY OVEREXPRESSED WILD-TYPE EGFR IN CANCER%REACTOME%R-HSA-5638302.3 Signaling by Overexpressed Wild-Type EGFR in Cancer 255324 2069 1950 1956 374 1839 7039 685 ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME DATABASE ID RELEASE 95%2473224 Antagonism of Activin by Follistatin 10468 3625 3624 10272 SUMOYLATION OF NUCLEAR ENVELOPE PROTEINS%REACTOME DATABASE ID RELEASE 95%9793242 SUMOylation of nuclear envelope proteins 7341 5905 7329 HDL REMODELING%REACTOME%R-HSA-8964058.4 HDL remodeling 9619 348 345 213 335 9388 1071 344 NTF4 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 95%9026357 NTF4 activates NTRK2 (TRKB) signaling 4915 4909 AMINO ACIDS REGULATE MTORC1%REACTOME%R-HSA-9639288.3 Amino acids regulate mTORC1 127124 51382 533 534 10312 389541 28956 9296 57521 55004 8649 10670 6009 64121 83667 64223 153129 8131 2475 201163 6396 55846 23334 58528 10542 144577 10325 23677 84219 10641 81929 652968 96459 729438 79726 154743 9681 57600 54468 11133 245972 245973 155066 9114 27244 51606 9550 523 525 526 527 528 529 8992 90423 SHC-MEDIATED CASCADE:FGFR3%REACTOME%R-HSA-5654704.3 SHC-mediated cascade:FGFR3 8823 8074 8817 2249 26281 2247 2246 6654 4893 2254 3265 RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-HSA-74158.4 RNA Polymerase III Transcription 4782 4784 6741 4774 5434 5435 5437 6908 51082 84265 55703 112495 11128 51728 9330 27297 661 9533 2976 10623 2975 5451 2972 6621 171568 55290 55814 6619 9328 2971 9329 7702 55718 10622 6618 10302 10621 6617 5440 5441 4781 DEFECTIVE TCN2 CAUSES TCN2 DEFICIENCY%REACTOME DATABASE ID RELEASE 95%3359454 Defective TCN2 causes TCN2 deficiency 6948 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 95%68877 Mitotic Prometaphase 10383 10382 4926 27436 7846 5566 10051 10592 7277 348995 6396 57122 55746 3320 23279 79023 79902 5903 54908 6232 8655 25909 8379 9183 1063 1062 9184 1060 991 151648 8243 55166 9126 5577 23244 23047 1058 79019 10735 151246 23063 9735 5885 10274 23332 79003 55055 81565 22919 348235 5048 23421 220134 55835 57082 57405 51143 147841 4085 64105 401541 10403 54820 80776 701 54821 378708 1781 23122 1780 79172 1778 81930 55920 84643 3796 9793 91687 57551 79682 5905 1783 5501 83540 80152 2491 5519 332 55143 699 11243 3619 140735 5515 11004 5516 5518 9212 25936 9738 11130 64946 79980 10726 5525 5526 55839 5527 9662 5528 7840 7514 5529 11064 22994 22995 7283 10733 80321 203068 114791 55722 1454 1453 55125 9814 85378 11190 115106 79441 95681 10426 27175 1069 891 653784 54801 983 10142 9702 10540 5347 5108 11116 4751 29922 55142 22897 27229 54930 5116 79959 80184 93323 1460 23354 64151 22981 1459 440145 8481 10844 1457 80254 121441 55755 10806 7532 10121 7531 55559 8636 11258 80097 55732 84131 113130 4957 9918 9133 140609 91754 10783 23397 6249 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 95%76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 5434 5435 5437 6908 51082 84265 55703 112495 11128 51728 9330 27297 661 9533 2976 10623 2975 2972 171568 55814 9328 2971 9329 55718 10622 10621 5440 5441 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 95%2559586 DNA Damage Telomere Stress Induced Senescence 474382 54145 4001 3024 1017 29855 25842 8091 1026 7290 23523 57634 3009 3008 3007 3006 3005 7157 3159 898 9134 1027 5925 8970 472 8331 8337 128312 8334 8335 8370 55766 10111 8341 4361 8342 8347 8290 8348 94239 8345 4683 26277 3013 25913 8340 10524 7013 65057 7014 8338 255626 54386 890 8900 3018 3017 85236 3014 8349 HYALURONAN DEGRADATION%REACTOME DATABASE ID RELEASE 95%2160916 Hyaluronan degradation 55576 57214 6677 10894 26503 2990 23553 960 3373 8372 3074 3073 6548 3161 11261 8692 DEFECTIVE F8 SECRETION%REACTOME%R-HSA-9672397.2 Defective F8 secretion 2157 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%R-HSA-1655829.4 Regulation of cholesterol biosynthesis by SREBP (SREBF) 6319 10498 6907 8648 3638 8720 79718 23054 5901 9871 5465 9632 10427 5469 10802 3837 80205 22937 10484 85441 4597 10499 96764 2224 1387 2222 6667 3157 1595 79071 6721 1717 2194 10654 6309 9453 4047 4520 3422 57678 4598 6713 7108 4800 4801 51360 4802 31 51128 6256 51141 6604 32 DENGUE VIRUS ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 95%9920588 Dengue virus activates modulates innate and adaptive immune responses 7706 3320 7448 23601 721 335 3326 8241 64135 23352 1654 115004 55763 340061 4153 23168 712 79577 1191 80349 57506 123169 716 9646 9641 54623 722 725 6773 PAUSING AND RECOVERY OF HIV ELONGATION%REACTOME DATABASE ID RELEASE 95%167290 Pausing and recovery of HIV elongation 6829 2963 2962 5434 5435 5436 5437 5438 5439 8178 25920 5430 5431 51224 5432 6924 5433 7936 6827 6749 9150 6917 905 1025 51497 7469 11198 904 8812 6921 6923 5440 5441 REGULATION OF GENE EXPRESSION IN ENDOCRINE-COMMITTED (NEUROG3+) PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 95%210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells 4821 4760 3642 50674 THE AIM2 INFLAMMASOME%REACTOME%R-HSA-844615.2 The AIM2 inflammasome 9447 29108 834 PLATELET CALCIUM HOMEOSTASIS%REACTOME DATABASE ID RELEASE 95%418360 Platelet calcium homeostasis 5023 5024 5025 5026 22953 6546 6547 3710 80228 487 488 489 84876 5027 7222 6717 9127 490 7225 491 808 492 493 6786 6543 3708 57113 3709 VITAMIN E TRANSPORT%REACTOME DATABASE ID RELEASE 95%8877627 Vitamin E transport 7274 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 95%73762 RNA Polymerase I Transcription Initiation 2071 57504 2966 57459 9112 2965 3065 2068 54815 5434 5435 64425 5437 7270 79101 2968 2967 10849 54700 53615 404672 5928 6908 902 10919 221830 51082 2648 9014 9015 9013 1107 7343 5931 84172 3066 2074 9533 8850 5440 5441 30834 4331 1108 1022 25885 9219 PEPTIDE HORMONE METABOLISM%REACTOME DATABASE ID RELEASE 95%2980736 Peptide hormone metabolism 5972 23478 60559 5126 2864 56605 28972 64924 2695 2999 90701 169026 139760 1803 183 59272 1499 4644 6934 5873 25924 149371 5443 346562 2641 1081 55763 1361 6804 2782 55770 3798 7252 3799 23265 94115 619373 60412 7941 1395 290 2688 54536 7349 10159 1215 10640 11336 590 1511 1522 1045 3952 4311 1066 9314 2922 3972 3630 6844 3626 3625 2784 3624 3623 3479 51764 2488 83729 43 2626 1509 2028 5034 57393 3800 1363 338557 3670 5122 1360 9789 1359 5080 1636 PHENYLALANINE METABOLISM%REACTOME DATABASE ID RELEASE 95%8964208 Phenylalanine metabolism 5053 259307 5860 5092 883 80150 RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%8941855 RUNX3 regulates CDKN1A transcription 4088 7040 4089 864 463 1026 7157 RECYCLING PATHWAY OF L1%REACTOME%R-HSA-437239.3 Recycling pathway of L1 7430 163 6456 5962 1759 57698 1175 1173 1785 4478 1808 8986 27330 6197 6196 5594 9252 6195 26052 1213 1211 3897 24137 8650 285643 160 161 REGULATION OF EXPRESSION AND FUNCTION OF TYPE I CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 95%9764274 Regulation of Expression and Function of Type I Classical Cadherins 23478 60559 2146 5045 28972 5046 90701 5928 1785 283106 9159 5931 27085 8726 288 1488 1487 29954 5925 8970 3728 8331 8337 128312 10585 8334 9314 8335 6597 8370 55766 8968 54971 8341 5594 8342 5595 8347 7764 8348 117581 94239 8345 3013 9839 8340 1495 8338 255626 1500 1508 3021 653604 3018 6615 3017 85236 3014 8349 7841 474382 7088 2060 54145 3065 1650 23028 100128731 1499 6185 6935 6184 23193 8289 58505 821 5589 746 1603 3703 4609 4343 192669 23112 27327 387893 999 26523 6591 4613 3066 116092 192670 27161 3170 7020 94234 57690 23396 93986 9861 6929 55810 23512 6233 687 79872 7750 348262 10009 7316 6714 10213 9743 4193 5706 6938 5707 5708 7414 5709 54737 7291 5700 5701 5702 1520 5704 5705 5682 5683 5684 5685 5686 10399 5717 1514 5718 5719 1460 11047 6667 5315 5713 1459 5714 5690 5691 1457 5692 5693 5694 7311 7979 5695 7490 7314 60436 5687 11171 5688 5689 23411 9789 SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME%R-HSA-3108214.4 SUMOylation of DNA damage response and repair proteins 51588 197370 1029 493861 9656 286053 23137 79677 56160 5371 54780 51564 8924 8535 6045 7341 648 8554 6015 7329 1912 1911 7518 80012 57332 348995 84733 9883 6612 6396 7703 129401 6613 9688 57122 23225 4927 23165 8021 55746 55706 23636 9631 7175 9972 165918 11097 23279 8086 23511 53371 8480 79023 1069 142 79902 10762 5903 7486 6672 672 8243 5893 9126 10735 5885 10274 7508 641 6117 6996 SLC-MEDIATED TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-9955298.1 SLC-mediated transport of organic anions 6566 1468 9356 160728 682 159963 57153 551 28231 126969 28234 53919 284111 9058 23539 6578 9123 9194 353189 133418 55867 11309 80736 204962 6576 23446 6567 60482 26503 116085 345274 10599 64849 6579 10864 8402 9376 DEFECTIVE CYP4F22 CAUSES ARCI5%REACTOME DATABASE ID RELEASE 95%5579005 Defective CYP4F22 causes ARCI5 126410 DEGRADATION OF CRY AND PER PROTEINS%REACTOME DATABASE ID RELEASE 95%9932298 Degradation of CRY and PER proteins 5706 5707 5708 5709 5700 5701 1408 1407 5187 5702 5704 5705 5682 8864 5683 8863 23291 5684 5685 5686 5717 5718 5719 11047 5713 5714 5690 5691 5692 5693 26224 5694 7311 7979 5695 7314 9861 8454 6233 5687 5688 9978 5689 7316 6500 10213 8945 7321 DEVELOPMENTAL LINEAGES OF THE MAMMARY GLAND%REACTOME DATABASE ID RELEASE 95%9924644 Developmental Lineages of the Mammary Gland 2255 1950 374 7039 5617 FORMATION OF WDR5-CONTAINING HISTONE-MODIFYING COMPLEXES%REACTOME%R-HSA-9772755.2 Formation of WDR5-containing histone-modifying complexes 57325 84148 9757 84661 51105 11091 80335 6871 5929 284058 58508 55683 4297 55689 2648 4221 55617 91272 23054 22976 8473 10474 10445 54934 9739 26009 51230 8850 9070 1810 51562 26993 7403 112869 29915 8085 79447 23067 30827 3054 259282 11168 DEFECTIVE GALM CAUSES GALAC4%REACTOME DATABASE ID RELEASE 95%9931929 Defective GALM causes GALAC4 130589 CASP8 ACTIVITY IS INHIBITED%REACTOME DATABASE ID RELEASE 95%5218900 CASP8 activity is inhibited 8772 8797 8737 355 356 8717 8795 7186 8743 841 DEFECTIVE F8 BINDING TO THE CELL MEMBRANE%REACTOME DATABASE ID RELEASE 95%9672395 Defective F8 binding to the cell membrane 2157 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%209952 Peptide hormone biosynthesis 3972 3626 7252 3625 3624 5443 3623 2488 94115 83729 5122 1081 RAS GTPASE CYCLE MUTANTS%REACTOME DATABASE ID RELEASE 95%9649913 RAS GTPase cycle mutants 3845 4893 3265 MITF-M-REGULATED MELANOCYTE DEVELOPMENT%REACTOME%R-HSA-9730414.5 MITF-M-regulated melanocyte development 60 1435 5443 23405 3397 427 4308 5829 89780 3978 2766 6595 6597 2033 6599 6598 9114 51606 5594 5595 3815 9550 523 526 6663 527 208 6601 6603 528 6602 6605 529 6604 8992 5077 597 634 4233 7837 3065 7299 25942 79083 3094 2315 1029 595 3662 1000 83439 6490 1017 994 1638 5454 1026 533 10085 1499 8600 6935 51176 6909 727936 4935 6932 4644 6934 7015 5873 79444 8289 54843 201595 2058 25924 5054 7391 3673 7306 10891 4343 7341 192669 23112 27327 999 26523 6591 7329 192670 4157 27161 7020 57690 4161 4160 4159 1729 5977 2932 7514 605 7534 8110 1908 6662 51520 1615 4140 3376 1906 7965 891 9521 6657 7529 9255 1910 26039 5347 5859 4141 6760 22797 5917 596 7545 3735 27022 257 672 1432 6926 7942 1387 4286 7030 57492 7532 7531 6195 7533 9274 4174 9275 4171 23411 10000 8193 86 COENZYME A BIOSYNTHESIS%REACTOME%R-HSA-196783.7 Coenzyme A biosynthesis 79717 60490 80025 80347 53354 79877 79646 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%R-HSA-195253.4 Degradation of beta-catenin by the destruction complex 7088 7089 166 3065 7091 83439 1499 51176 6932 6934 54764 5519 5515 5516 5518 9861 6233 9978 5525 5526 8312 2932 5527 7316 324 5528 1452 5529 139285 10213 8945 5706 5707 5708 5709 5700 5701 5702 5704 1488 5705 1487 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 8454 7090 5687 5688 5689 23401 10023 6500 MET RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 95%8875656 MET receptor recycling 4233 2549 1399 382 23163 5867 53916 1398 3082 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 95%112399 IRS-mediated signalling 2252 2251 8074 2249 2248 2247 57761 2246 2323 2322 152831 8823 5295 5296 5140 2264 5781 4893 5290 5291 5170 27006 2255 117145 9846 54106 3667 2549 8660 30849 10818 208 8817 26281 9965 5289 6654 2254 3265 REVERSE TRANSCRIPTION OF HIV RNA%REACTOME DATABASE ID RELEASE 95%162589 Reverse Transcription of HIV RNA 5478 PRIMITIVE STREAK FORMATION%REACTOME DATABASE ID RELEASE 95%9754189 Primitive streak formation 8320 6862 387332 4087 8928 4088 4089 652 1499 6657 51176 145258 83881 6932 51592 5460 79923 INTERACTIONS OF TAT WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 95%176034 Interactions of Tat with host cellular proteins 1025 904 DISSOLUTION OF FIBRIN CLOT%REACTOME%R-HSA-75205.5 Dissolution of Fibrin Clot 5327 5328 3273 5329 5055 6281 5271 302 5340 5269 5054 5345 5270 PRE-NOTCH PROCESSING IN GOLGI%REACTOME DATABASE ID RELEASE 95%1912420 Pre-NOTCH Processing in Golgi 5045 6400 2683 3955 5870 4851 4853 10402 4854 4855 6484 5986 10959 6487 4242 487 488 489 SIGNALING BY HIPPO%REACTOME%R-HSA-2028269.3 Signaling by Hippo 9414 261734 1856 7082 7531 7529 92597 9113 154810 26524 23286 55233 51421 60485 6788 6789 25937 836 10413 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND LUMINAL EPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 95%9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 1950 374 7039 PTK6 REGULATES CELL CYCLE%REACTOME DATABASE ID RELEASE 95%8849470 PTK6 Regulates Cell Cycle 1027 595 5753 1019 1017 898 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME%R-HSA-71403.5 Citric acid cycle (TCA cycle) 8803 50 3419 8801 3418 6389 1743 81689 54949 57001 92259 6391 644096 6390 6392 57128 122961 1431 23530 1738 4967 3421 751071 38 23410 3420 135154 2271 4191 2395 8802 10131 INACTIVATION OF CSF3 (G-CSF) SIGNALING%REACTOME DATABASE ID RELEASE 95%9705462 Inactivation of CSF3 (G-CSF) signaling 3716 1440 8651 6776 1441 7297 6772 6850 3055 9616 8065 7311 9021 7314 7323 7322 6233 4067 7316 6921 6774 6923 6777 7321 3717 VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME%R-HSA-432040.5 Vasopressin regulates renal water homeostasis via Aquaporins 113 114 554 115 107 108 4645 55970 109 196883 22841 5566 5567 551 5568 54331 59345 2793 2792 5573 5575 2791 5576 5577 2790 2788 2782 360 2787 361 2786 2785 2784 2783 51764 10681 358 359 8766 2778 94235 111 112 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%R-HSA-451306.4 Ionotropic activity of kainate receptors 1739 2900 83988 808 2899 2898 2897 1742 1741 2901 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME DATABASE ID RELEASE 95%177504 Retrograde neurotrophin signalling 163 6456 4803 10126 4914 1759 26052 1213 1211 1175 1173 1785 160 161 COLLAGEN DEGRADATION%REACTOME DATABASE ID RELEASE 95%1442490 Collagen degradation 85007 1307 84570 5045 4317 1306 4318 1991 4312 6868 4313 1514 1297 5645 1513 8754 9313 1310 7373 4320 4314 136227 4321 164656 91522 80781 4322 1509 4319 4316 1305 1508 4323 1303 4324 102 4327 1299 1298 1308 SLC15A4:TASL-DEPENDENT IRF5 ACTIVATION%REACTOME%R-HSA-9860276.3 SLC15A4:TASL-dependent IRF5 activation 8517 121260 80231 3663 3551 1147 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME DATABASE ID RELEASE 95%159227 Transport of the SLBP independent Mature mRNA 23636 9631 7175 9972 11097 23279 8086 23511 10482 53371 8480 79023 79902 10762 5903 22916 4686 1977 348995 9883 6396 129401 9688 57122 23225 10189 4927 23165 55746 8021 55706 GPER1 SIGNALING%REACTOME DATABASE ID RELEASE 95%9634597 GPER1 signaling 113 114 115 107 108 55970 109 196883 5566 5567 2852 5568 54331 59345 3688 2793 2781 2792 5573 346562 5575 2791 5576 5577 2790 2788 2782 2787 2786 2785 2784 2783 51764 10681 2778 2771 3678 2770 6714 94235 111 112 2773 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%R-HSA-933542.3 TRAF6 mediated NF-kB activation 7706 4214 4793 28512 3551 177 5970 64135 28511 84282 7186 7189 89122 8517 4792 3146 23586 4790 351 57506 4791 1147 6285 6288 6283 SIALIC ACID METABOLISM%REACTOME DATABASE ID RELEASE 95%4085001 Sialic acid metabolism 6480 256435 10825 27090 30815 338596 10559 84620 8869 55907 8128 140838 26503 29906 54187 80896 81849 51046 7903 4758 10402 10610 129807 6483 4759 2720 6482 6484 55808 6487 6489 5476 10020 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME%R-HSA-70221.8 Glycogen breakdown (glycogenolysis) 2548 808 178 5261 5260 8908 5834 2992 5836 83592 5837 5255 5256 5257 5236 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%R-HSA-2022377.11 Metabolism of Angiotensinogen to Angiotensins 5972 1511 2999 183 59272 1522 290 1509 10159 1215 2028 4311 1066 1360 1359 1361 1636 REGULATION OF NPAS4 MRNA TRANSLATION%REACTOME%R-HSA-9768778.2 Regulation of NPAS4 mRNA translation 4343 192669 23112 27327 26523 192670 266743 27161 57690 ATTACHMENT AND ENTRY%REACTOME%R-HSA-9678110.5 Attachment and Entry 7415 1514 7113 59272 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%R-HSA-3371571.3 HSF1-dependent transactivation 3305 2033 3320 10728 64223 26353 3326 3304 84335 2475 3297 3281 3312 815 1410 3337 2288 816 817 57521 1387 818 3306 INTERLEUKIN-7 SIGNALING%REACTOME DATABASE ID RELEASE 95%1266695 Interleukin-7 signaling 3561 3716 1154 8651 6776 5896 5897 5295 5296 3082 6597 8503 3667 8968 3574 8660 3575 85480 8835 64109 6774 54014 653604 3718 6777 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%R-HSA-170822.6 Regulation of Glucokinase by Glucokinase Regulatory Protein 23636 9631 7175 9972 11097 23279 8086 23511 53371 8480 79023 79902 10762 5903 348995 9883 6396 129401 9688 57122 23225 4927 2646 2645 23165 55746 8021 55706 RESPIRATORY SYNCYTIAL VIRUS (RSV) GENOME REPLICATION, TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-9820965.1 Respiratory syncytial virus (RSV) genome replication, transcription and translation 23478 1459 60559 5045 3320 1457 28972 90701 3326 5499 3837 3312 7514 5500 5501 1460 9789 SENSORY PERCEPTION OF SOUR TASTE%REACTOME%R-HSA-9729555.2 Sensory perception of sour taste 133060 3759 RPIA DEFICIENCY: FAILED CONVERSION OF RU5P TO R5P%REACTOME%R-HSA-6791461.4 RPIA deficiency: failed conversion of RU5P to R5P 22934 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-2151201.4 Transcriptional activation of mitochondrial biogenesis 56652 10498 6907 11232 8648 5442 79718 4208 6742 10891 8841 9611 23054 51106 211 808 133522 5465 23409 3054 6648 23408 2551 23082 2746 5469 4209 3418 7978 84808 4899 2747 80205 23373 85441 10499 2101 96764 64784 200186 1387 814 55902 9572 1386 7019 64216 23410 6256 506 6604 54205 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME%R-HSA-73776.5 RNA Polymerase II Promoter Escape 2071 2966 2965 83860 2963 2962 8148 2068 5434 6872 5435 5436 51616 6874 5437 6873 5438 5439 2968 2967 404672 6881 5430 5431 138474 54457 5432 5433 6908 902 6880 6883 2961 2960 6882 6884 2959 2958 129685 2957 6875 6878 6877 6879 5440 5441 4331 1022 SIGNALING BY ALK%REACTOME DATABASE ID RELEASE 95%201556 Signaling by ALK 3561 3065 5335 25942 639 4192 5295 5296 8841 389658 238 5290 5291 4609 5764 2033 5777 3667 285016 3066 4613 10818 3091 1786 6774 5803 3718 29126 NEIL3-MEDIATED RESOLUTION OF ICLS%REACTOME DATABASE ID RELEASE 95%9636003 NEIL3-mediated resolution of ICLs 55247 CREATION OF C4 AND C2 ACTIVATORS%REACTOME%R-HSA-166786.4 Creation of C4 and C2 activators 2219 4153 78989 5648 712 713 714 715 716 2220 1401 8547 10584 MITOCHONDRIAL TRANSLATION%REACTOME%R-HSA-5368287.5 Mitochondrial translation 54471 6150 55168 64949 28973 65080 51642 54998 5018 10573 11222 128308 51649 9553 64960 92259 64963 63875 64965 64968 55052 55173 64969 51250 51373 26284 51650 51253 60488 51258 219927 29074 56945 28998 64975 79590 64976 64979 115416 64978 23107 28957 64928 4706 7818 51263 29088 51021 57129 54534 51023 51264 51069 84545 78988 122704 65993 64981 10240 64983 3396 63931 26589 54460 6182 6183 118487 51073 116540 740 124995 54148 116541 55037 29093 9801 51116 10884 54948 51318 7284 9617 4508 4509 84340 123263 4512 4513 4514 4528 4519 4539 85476 219402 54516 4540 4541 4535 4536 4537 4538 10102 92399 91574 64432 65003 64951 65005 65008 28977 90480 51081 LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME%R-HSA-166662.5 Lectin pathway of complement activation 2219 2220 8547 10584 4153 78989 5648 PHENYLALANINE AND TYROSINE METABOLISM%REACTOME DATABASE ID RELEASE 95%8963691 Phenylalanine and tyrosine metabolism 5053 259307 5860 5092 883 80150 2954 3081 6898 3242 2184 ISOVALERIC ACIDEMIA%REACTOME%R-HSA-9914355.1 Isovaleric acidemia 3712 TICAM1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 95%5602566 TICAM1 deficiency - HSE 7098 148022 METAL ION ASSIMILATION FROM THE HOST%REACTOME DATABASE ID RELEASE 95%9638482 Metal ion assimilation from the host 3040 3043 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 95%418359 Reduction of cytosolic Ca++ levels 6546 6543 6547 6717 490 491 808 492 493 487 488 489 SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME%R-HSA-3899300.7 SUMOylation of transcription cofactors 51588 25942 4869 8648 1487 1616 10499 9612 10891 8204 1387 4152 8535 6294 1655 7341 10210 6045 2033 9994 115426 7690 648 8554 10521 6015 7329 57591 10401 1912 1911 80012 57332 10155 84733 6612 7703 6613 59348 11315 3622 28996 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME DATABASE ID RELEASE 95%73929 Base-Excision Repair, AP Site Formation 474382 4350 54145 8970 8331 8337 128312 8334 8335 4968 8370 55766 8341 8342 8930 8347 8290 8348 55247 94239 23583 8345 26277 3013 252969 25913 8340 7013 65057 7014 8338 79661 255626 54386 6996 4913 3018 3017 85236 3014 8349 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296059.4 G protein gated Potassium channels 3772 55970 3762 3763 3765 3766 3768 54331 59345 2793 2792 3773 2791 2790 2788 2782 2787 2786 2785 2784 2783 51764 10681 9568 94235 3760 3761 2550 3759 MODULATION BY MTB OF HOST IMMUNE SYSTEM%REACTOME%R-HSA-9637628.2 Modulation by Mtb of host immune system 4360 7316 7311 7314 7097 567 6233 ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%111448 Activation of NOXA and translocation to mitochondria 5366 7029 7027 1869 7157 TRANSPORT AND METABOLISM OF PAPS%REACTOME%R-HSA-174362.8 Transport and metabolism of PAPS 1836 9061 9060 284129 51000 10861 347734 CYP2E1 REACTIONS%REACTOME%R-HSA-211999.4 CYP2E1 reactions 1557 1549 1571 1548 1555 1565 1559 1572 1553 1558 29785 EPHB-MEDIATED FORWARD SIGNALING%REACTOME%R-HSA-3928662.4 EPHB-mediated forward signaling 9475 60 1072 5879 6093 6383 7074 3984 3985 2534 8976 5921 998 71 64283 10109 10552 10093 10092 10095 4067 10094 5058 10097 2904 10096 5747 7525 387 2902 8997 6453 3265 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME DATABASE ID RELEASE 95%975144 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation 7335 57162 8517 7334 57161 3551 1147 246330 7189 3654 TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-HSA-6781827.3 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 2873 51138 9318 10450 91603 7874 6233 57654 9978 27339 7316 5440 5441 4331 1022 2071 2966 1161 2965 9716 2068 5434 5435 5436 5437 5438 10714 5439 5424 2968 8178 8451 5425 2967 5981 404672 57804 8533 5430 3978 2073 5431 2072 5432 5982 64708 5433 56655 902 5983 7515 6917 10987 10980 5426 5427 3980 57461 51426 50813 2067 10920 1642 54107 7311 7507 2074 5111 7314 56949 6117 5984 5985 6119 6118 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%R-HSA-451326.4 Activation of kainate receptors upon glutamate binding 55970 83988 54331 59345 2793 2792 2791 2790 2788 2782 2787 2786 2900 2785 808 2784 2783 5330 51764 5331 10681 1742 2901 1741 23236 1739 94235 2899 2898 2897 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO STRA6 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9918449 Defective visual phototransduction due to STRA6 loss of function 64220 7276 5950 RETINOID METABOLISM AND TRANSPORT%REACTOME%R-HSA-975634.4 Retinoid metabolism and transport 4035 29967 83875 1645 335 5948 336 26020 375790 337 54884 57016 53630 5406 55937 1208 3339 3949 51109 345 9227 6383 8644 221914 5950 151056 9672 10082 5947 6385 2262 344 6382 2239 7804 4036 348 2719 2817 1109 338 338328 7276 4023 EXPRESSION OF NOTCH2NL GENES%REACTOME DATABASE ID RELEASE 95%9911233 Expression of NOTCH2NL genes 100996717 1991 100996763 388677 RUNX3 REGULATES IMMUNE RESPONSE AND CELL MIGRATION%REACTOME DATABASE ID RELEASE 95%8949275 RUNX3 Regulates Immune Response and Cell Migration 6696 865 864 3683 3676 DEFECTIVE CYP19A1 CAUSES AEXS%REACTOME DATABASE ID RELEASE 95%5579030 Defective CYP19A1 causes AEXS 1588 PYRIMIDINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%500753 Pyrimidine biosynthesis 7372 790 1723 ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 95%2559585 Oncogene Induced Senescence 7027 1029 1021 1019 1871 1870 7029 1869 5925 6667 3397 1030 7157 2114 4343 2113 192669 23112 27327 1032 1031 26523 7311 192670 7314 5594 57690 5595 6233 2077 7316 4194 4193 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO DAXX MUTATIONS%REACTOME%R-HSA-9670613.2 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations 1616 546 METABOLISM OF SEROTONIN%REACTOME%R-HSA-380612.6 Metabolism of serotonin 4128 217 TRANSLOCATION OF SLC2A4 (GLUT4) TO THE PLASMA MEMBRANE%REACTOME%R-HSA-1445148.4 Translocation of SLC2A4 (GLUT4) to the plasma membrane 11127 10890 6810 79058 57148 6814 4644 5879 5563 5564 149371 5565 4627 9371 55763 51422 55770 5571 808 23265 53632 60412 54536 8766 8773 2810 7534 10640 11336 5898 207 5867 5872 7529 23433 4218 4012 6517 4641 10971 6844 23216 7532 7531 51552 7533 9847 57186 208 9882 22920 GAP JUNCTION ASSEMBLY%REACTOME DATABASE ID RELEASE 95%190861 Gap junction assembly 10052 57165 375519 57369 2702 2701 2700 127534 2709 2707 2697 2706 2705 2703 219770 125111 10804 81025 84694 DEFECTIVE SLC1A1 IS IMPLICATED IN SCHIZOPHRENIA 18 (SCZD18) AND DICARBOXYLIC AMINOACIDURIA (DCBXA)%REACTOME%R-HSA-5619067.4 Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) 6505 FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190370 FGFR1b ligand binding and activation 2255 27006 7049 10755 2248 2247 2246 INTERLEUKIN-10 SIGNALING%REACTOME%R-HSA-6783783.5 Interleukin-10 signaling 6351 3716 6352 7076 1440 3552 3587 6348 3383 6347 5743 6349 3553 7297 1435 6364 6363 3593 3592 6367 1230 3586 5724 2208 7850 3557 2920 7124 3976 3576 729230 7133 7132 3569 3627 3588 2919 1437 2357 3606 941 942 1234 6774 3554 ALKBH2 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 95%112122 ALKBH2 mediated reversal of alkylation damage 121642 ENHANCED BINDING OF GP1BA VARIANT TO VWF MULTIMER:COLLAGEN%REACTOME DATABASE ID RELEASE 95%9845620 Enhanced binding of GP1BA variant to VWF multimer:collagen 2811 2812 7450 2815 2814 TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME%R-HSA-1299344.3 TWIK-related spinal cord K+ channel (TRESK) 338567 FORMATION OF THE NEPHRIC DUCT%REACTOME DATABASE ID RELEASE 95%9830364 Formation of the nephric duct 51316 5979 5076 57526 3975 10406 652 3203 7849 2247 255743 1499 2625 2122 2018 3214 3400 130497 DEFECTIVE POMT1 CAUSES MDDGA1, MDDGB1 AND MDDGC1%REACTOME%R-HSA-5083633.3 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 29954 10585 1605 MET ACTIVATES PTPN11%REACTOME DATABASE ID RELEASE 95%8865999 MET activates PTPN11 4233 2549 5781 3082 CALNEXIN CALRETICULIN CYCLE%REACTOME%R-HSA-901042.5 Calnexin calreticulin cycle 2923 91445 55741 6048 10956 811 80267 84447 10299 23193 9695 10206 56886 267 821 7844 11253 5589 55757 11236 51009 6400 7311 7314 6233 7316 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN EXTRACELLULAR MATRIX, FOCAL ADHESION AND EPITHELIAL-TO-MESENCHYMAL TRANSITION%REACTOME%R-HSA-9926550.1 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition 5829 999 7837 201595 5054 3673 1000 10085 6657 6935 727936 GILTERITINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702590 gilteritinib-resistant FLT3 mutants 2322 CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT%REACTOME%R-HSA-9603798.3 Class I peroxisomal membrane protein import 10478 5825 8504 5195 55670 5827 5828 5193 91452 5194 9409 84896 5824 225 8799 54332 51024 215 11264 PACKAGING OF TELOMERE ENDS%REACTOME DATABASE ID RELEASE 95%171306 Packaging Of Telomere Ends 474382 54145 8970 8331 8337 128312 8334 8335 8370 55766 8341 8342 8347 8290 8348 94239 8345 26277 3013 25913 8340 7013 65057 7014 8338 255626 54386 3018 3017 85236 3014 8349 N-GLYCAN ANTENNAE ELONGATION%REACTOME DATABASE ID RELEASE 95%975577 N-Glycan antennae elongation 6480 2683 8128 11320 4249 8703 8704 8702 25834 51046 338596 9334 6484 9331 11282 OTHER SEMAPHORIN INTERACTIONS%REACTOME%R-HSA-416700.3 Other semaphorin interactions 57556 54209 10154 7305 8482 9723 5362 5365 971 3672 80031 5788 10507 64218 9037 3688 91584 23129 5361 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME DATABASE ID RELEASE 95%9646303 Evasion of Oncogene Induced Senescence Due to p14ARF Defects 1029 DENGUE VIRUS ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 95%9918485 Dengue Virus Attachment and Entry 163 5045 4360 375790 440400 10461 91937 7301 3339 1175 4061 3309 1173 51234 22924 6383 5295 221914 9672 55236 10082 6385 2262 945 2621 6382 9039 2239 558 2719 7318 9076 2817 5627 7317 10533 79876 26762 3921 11314 929 30835 160 161 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-HSA-75955.4 RNA Polymerase II Transcription Elongation 905 8812 6921 6923 5440 5441 4331 1022 2071 2966 6829 2965 2963 2962 2068 5434 5435 5436 5437 5438 5439 2968 8178 2967 22916 404672 5430 25920 4686 5431 5432 51224 5433 6924 7936 902 6827 6749 9150 6917 1025 51497 7469 11198 904 4298 6830 27125 23168 55840 4300 85403 79577 55677 80349 123169 9646 54623 MEIOSIS%REACTOME%R-HSA-1500620.4 Meiosis 474382 54145 4001 1017 4292 7329 8468 10734 6847 27030 4438 4439 10388 84057 56979 23626 9985 1019 11144 23345 23224 644186 23353 25777 27127 93426 256126 8970 472 56158 8331 29893 672 8337 675 8243 128312 50511 9126 8334 8335 63979 10735 8370 55766 10111 5885 8968 5932 10274 8341 4361 8342 7156 8347 8290 8348 94239 8345 55732 4683 26277 3013 25913 8340 7013 641 65057 7014 8338 545 6117 255626 54386 6119 3021 653604 3018 5888 6118 3017 85236 3014 5889 8349 3306 ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME%R-HSA-6803544.3 Ion influx efflux at host-pathogen interface 6556 475 538 51248 SYNTHESIS OF PS%REACTOME DATABASE ID RELEASE 95%1483101 Synthesis of PS 9791 81490 TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME%R-HSA-1299361.3 TWIK-related alkaline pH activated K+ channel (TALK) 83795 89822 TRANSLATION OF STRUCTURAL PROTEINS%REACTOME%R-HSA-9694635.5 Translation of Structural Proteins 7841 29801 25921 253832 51201 55741 1650 11320 51125 4247 51304 100128731 4249 6185 7991 4124 4245 6184 25834 23193 58505 201595 2530 79844 821 11253 5589 51114 746 1603 3703 7341 3276 143 2931 7329 56965 83666 84875 79668 54956 54625 6233 2932 7316 10610 1452 6483 6482 6484 6487 6480 256435 27090 7311 7314 6732 2589 6733 84061 11282 IMPAIRED BRCA2 BINDING TO SEM1 (DSS1)%REACTOME DATABASE ID RELEASE 95%9763198 Impaired BRCA2 binding to SEM1 (DSS1) 7979 675 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 95%2029480 Fcgamma receptor (FCGR) dependent phagocytosis 10006 60 3326 10810 2268 9844 4644 5879 23646 3710 3984 5295 5296 4627 5290 5291 2212 63916 71 196051 4771 7454 5580 7456 10109 84513 8398 1398 1793 10552 10093 10092 10095 4067 10094 10097 695 10096 3708 147179 3709 25 4690 3320 5335 10458 122618 51517 55845 4650 644150 1072 917 2209 5337 5338 2534 4651 8976 8936 6850 3055 4620 5581 10787 4641 2214 10152 998 10768 5594 5595 10451 7410 3071 5058 10163 5747 7525 7409 23191 26999 5336 MODULATION OF HOST RESPONSES BY IFN-STIMULATED GENES%REACTOME DATABASE ID RELEASE 95%9909505 Modulation of host responses by IFN-stimulated genes 25820 7706 8517 7318 23586 3551 9451 3429 64135 2537 9246 51191 2289 10964 3309 22926 9636 1147 RELAXIN RECEPTORS%REACTOME DATABASE ID RELEASE 95%444821 Relaxin receptors 117579 3640 122042 51289 59350 10022 6019 339403 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%R-HSA-187577.5 SCF(Skp2)-mediated degradation of p27 p21 595 1017 1026 9861 6233 7316 10213 5706 5707 5708 5709 1019 5700 5701 5702 898 5704 6502 5705 5682 5683 9134 5684 1027 5685 5686 5717 5718 5719 11047 5713 5714 5690 5691 5692 5693 5694 1163 7311 7979 5695 7314 8454 5687 5688 5689 890 8900 5753 6500 LACTOSE SYNTHESIS%REACTOME%R-HSA-5653890.4 Lactose synthesis 3906 2683 6513 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%R-HSA-446210.4 Synthesis of UDP-N-acetyl-glucosamine 5238 5973 51005 55577 2673 6675 9945 64841 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 95%73933 Resolution of Abasic Sites (AP sites) 4350 142 10714 5424 5425 5981 57804 3978 5982 56655 2237 5983 7515 5423 5426 5427 3980 10038 4968 54107 11284 5111 8930 23583 252969 79661 6117 5984 6996 5985 6119 4913 6118 8505 54936 328 SHC1 EVENTS IN EGFR SIGNALING%REACTOME%R-HSA-180336.4 SHC1 events in EGFR signaling 255324 2069 1950 1956 374 1839 6464 6654 4893 7039 685 3265 PTEN REGULATION%REACTOME%R-HSA-6807070.4 PTEN Regulation 2146 23186 10014 5371 5928 80351 1958 7157 80243 5931 7874 8975 23608 5987 4734 2444 2122 1822 84232 8726 7101 57167 1108 57504 5468 9112 53615 5978 10273 11060 5594 5595 1386 208 6615 57459 3065 54815 23028 51564 389541 8841 28956 57521 8535 55004 8649 4343 6045 1107 10670 192669 6009 23112 648 27327 6015 26523 23466 6591 3066 192670 64121 64223 27161 1912 57690 1911 153129 9861 81847 23512 6233 80012 57332 84733 2475 58528 10542 10325 7316 8658 10213 9219 5706 5707 5708 5709 207 5700 5701 5702 5728 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 1460 11047 5713 1459 5714 23252 5690 5691 1457 5692 5693 5694 7311 7979 5695 7314 5687 5688 5689 10000 331 3725 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME%R-HSA-203641.3 NOSTRIN mediated eNOS trafficking 1785 115677 4846 857 8976 VITAMIN B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME DATABASE ID RELEASE 95%964975 Vitamin B6 activation to pyridoxal phosphate 316 55163 8566 NFE2L2 REGULATING MDR ASSOCIATED ENZYMES%REACTOME%R-HSA-9818032.1 NFE2L2 regulating MDR associated enzymes 10061 2033 8714 4780 9429 4363 1387 7975 DEFECTIVE RHAG CAUSES REGULATOR TYPE RH-NULL HEMOLYTIC ANEMIA (RHN)%REACTOME%R-HSA-5619042.4 Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN) 6005 ZNF598 AND THE RIBOSOME-ASSOCIATED QUALITY TRIGGER (RQT) COMPLEX DISSOCIATE A RIBOSOME STALLED ON A NO-GO MRNA%REACTOME DATABASE ID RELEASE 95%9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA 84164 10973 7323 6233 7322 6152 6155 6154 6157 9349 6156 7316 6159 6158 23521 51121 6175 11224 6164 200916 6166 6122 7321 6165 6124 6168 6123 6167 6169 6125 116832 25873 6160 6161 140801 4736 6130 6133 9045 6230 6232 6132 6210 6176 6231 6135 6234 6134 6235 6137 6191 6136 2197 6193 6171 6192 6170 6194 6173 51065 6128 140032 6129 6205 6142 6227 6141 6204 6144 6207 6143 6229 6146 90850 6206 6147 6228 6181 6139 6209 6138 6208 6188 7311 6187 6223 7314 6201 6189 6222 6203 6224 6202 6218 6217 3921 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%R-HSA-1855167.3 Synthesis of pyrophosphates in the cytosol 11163 3705 64768 9807 170685 23262 11165 117283 9677 55190 REGULATION OF CDH19 EXPRESSION AND FUNCTION%REACTOME%R-HSA-9764302.3 Regulation of CDH19 Expression and Function 6663 1495 1500 3728 28513 80149 1499 PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME%R-HSA-8849469.3 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 7316 867 1796 7311 116985 7314 5753 207 6233 RESISTANCE OF ERBB2 KD MUTANTS TO OSIMERTINIB%REACTOME DATABASE ID RELEASE 95%9665247 Resistance of ERBB2 KD mutants to osimertinib 11140 3320 2064 55914 SUCCINYL-COA BIOSYNTHESIS%REACTOME%R-HSA-9853506.1 Succinyl-CoA Biosynthesis 1743 1738 4967 92259 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 95%1912422 Pre-NOTCH Expression and Processing 474382 5045 54145 861 595 5986 10959 4242 487 488 3516 489 7157 4343 192669 23112 27327 26523 192670 27161 57690 5870 8850 6484 6487 22938 55534 2683 5584 7027 100996717 51548 1991 1999 100996763 1871 388677 23509 56983 7029 1869 8970 8331 9794 2648 8337 128312 1387 8334 8335 2033 8370 55766 6400 8968 8341 3955 8342 84441 8347 8348 94239 8345 3013 8340 10046 4851 8338 4853 255626 10402 4854 4855 3021 653604 3725 3018 3017 85236 3014 8349 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-HSA-372708.3 p130Cas linkage to MAPK signaling for integrins 2244 2266 54518 5906 5908 7450 2243 7094 1398 3690 3674 9564 5747 6714 2335 ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 95%9026527 Activated NTRK2 signals through PLCG1 5335 4915 4909 627 AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME%R-HSA-141444.4 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 54821 378708 1781 23122 1780 79172 1778 81930 55920 84643 3796 9793 91687 57551 79682 5905 1783 5501 83540 80152 2491 5519 332 55143 699 11243 3619 140735 5515 11004 5516 5518 9212 25936 11130 64946 79980 348995 10726 6396 5525 5526 55839 5527 5528 7514 57122 5529 55746 23279 79023 79902 5903 54908 6232 8655 5347 25909 8379 9183 1063 1062 9184 1060 991 151648 55166 1058 79019 151246 9735 23332 79003 55055 81565 22919 348235 5048 23421 220134 57082 57405 51143 147841 4085 64105 401541 10403 6249 54820 80776 701 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%R-HSA-445717.4 Aquaporin-mediated transport 113 114 554 115 107 108 55970 109 196883 5566 5567 5568 54331 59345 4284 2782 360 361 375318 362 363 364 282679 343 366 10681 358 359 89872 8766 2778 4645 22841 551 2793 2792 5573 5575 2791 5576 5577 2790 2788 2787 2786 2785 2784 2783 51764 94235 111 112 EXPRESSION OF BMAL (ARNTL), CLOCK, AND NPAS2%REACTOME DATABASE ID RELEASE 95%9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 5469 4209 6097 4862 6096 6095 10498 6907 80205 8648 79718 23373 406 85441 10499 10743 96764 4208 10891 9575 8204 64784 8841 9611 200186 1387 23054 2033 9572 1386 5465 23411 6256 6604 CELLULAR RESPONSES TO MECHANICAL STIMULI%REACTOME%R-HSA-9855142.1 Cellular responses to mechanical stimuli 113 6696 114 115 10266 107 783 108 55970 109 10203 196883 5566 5567 5568 54331 2767 4846 59345 6772 5027 2782 781 782 784 2776 59341 2697 10681 5175 9641 2778 9780 1003 25 253260 84290 824 5970 826 5586 5573 5575 5576 5577 8517 3690 3685 3678 4323 1147 3551 1499 3339 59284 5296 3688 5770 8912 5519 10413 5290 5291 5170 55615 5515 64223 808 5518 2475 2324 3791 7414 207 5029 7094 302 2793 5520 2792 2534 2791 2790 2788 2787 4792 2786 2785 5293 2784 4790 2783 51764 5747 94235 24145 79109 133 111 112 SYNTHESIS OF DNA%REACTOME%R-HSA-69239.5 Synthesis of DNA 23649 5422 5557 5558 10714 5424 898 5425 57804 5981 51343 6502 3978 9134 56655 5426 5427 54107 1017 64785 8318 9837 84296 51659 2237 9861 6233 9978 7316 10213 51529 7321 5706 8881 64682 5707 25906 5708 11065 5709 8697 7324 10393 29945 27338 119504 5700 5701 29882 5702 246184 996 5704 51434 5705 51433 5682 5683 5684 5982 5685 5686 5983 5717 5718 5719 11047 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 5111 7314 4172 8454 4173 4174 5687 4175 5688 4176 4171 5689 990 1763 84515 51053 6117 5000 5984 5001 890 5985 6119 8900 6500 23595 6118 23594 81620 4998 4999 INFLAMMASOMES%REACTOME%R-HSA-622312.3 Inflammasomes 9447 5027 29108 10628 58484 4790 351 4210 5970 3326 10910 7295 9051 114548 3162 22861 834 4791 596 24145 598 NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013508.2 NOTCH3 Intracellular Domain Regulates Transcription 2033 84441 23462 8850 3280 5087 10046 9787 171558 4851 23286 4854 26508 6772 388585 9794 2648 22938 23129 23493 1387 2173 3516 55534 RAS PROCESSING%REACTOME DATABASE ID RELEASE 95%9648002 RAS processing 2342 23463 2339 51104 10434 9986 402 51125 3845 808 377630 81926 5147 58489 5588 5593 51114 598 4893 3265 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 95%71387 Carbohydrate metabolism 5566 5567 5568 2524 2523 1836 8705 9334 9331 4123 22934 23324 2683 7086 11041 5261 378884 5260 8908 10057 7957 83592 5837 51000 5255 11046 11261 5256 8692 5257 347734 3038 2998 3037 2632 55576 5507 57214 3036 6677 10894 2592 9469 11285 126792 5226 2646 2542 2645 9061 9060 9348 64579 26229 64711 2548 2131 3340 90161 222537 2799 10855 26035 9957 60495 9955 6448 9956 8509 4669 6383 5834 221914 9653 5836 266722 9672 10082 6385 9953 9951 2262 6382 9394 28 2239 2137 2135 2719 2817 2588 6233 960 7316 8021 2997 55276 231 6888 6007 6006 2525 7311 7314 4125 4126 5091 5236 51071 26330 1462 2990 23553 3373 10331 112937 348995 132158 8372 113189 9883 3795 3074 6396 3073 129401 63827 9688 178 1634 3425 79411 57122 411 2720 3423 23225 633 1464 4927 89944 23165 1463 10675 55746 55706 23636 9631 7175 9972 11097 23279 8086 23511 53371 6120 8480 221823 79023 729020 284129 79902 23729 10762 10861 5631 25796 5903 5634 64080 10090 29940 51363 92126 2992 7360 80146 10327 51084 9942 6652 51181 4060 375790 2331 130589 176 3339 5519 3906 5515 5105 5516 808 2203 5518 27087 8789 2584 92579 2582 54020 124872 57818 8707 5106 9917 8708 10690 92370 64131 64132 5528 2526 6483 10317 2529 6482 7167 26007 2528 6484 5223 135152 5224 2527 230 6487 2539 80201 2538 283209 2821 2027 3098 2026 5214 5230 5232 3099 132789 2597 3101 11081 8534 387712 23563 5210 5211 93010 4969 30815 5213 2023 10678 8703 10007 8704 226 8702 83440 4166 229 9435 669 5207 4958 79369 5208 216 5549 5209 6548 3161 1514 22856 337876 55501 50515 55790 54480 166012 79586 55454 6513 56548 26503 10402 SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME DATABASE ID RELEASE 95%3108232 SUMO E3 ligases SUMOylate target proteins 51588 5371 3183 1655 7157 7518 6790 348995 9883 5465 6396 5987 9641 129401 9688 57122 23225 4927 6670 23165 3090 668 55746 55706 23636 9631 5468 7175 9112 9972 11097 23279 8086 5241 23511 53371 4869 7421 8480 5970 79023 3190 142 79902 10762 5903 2099 1487 1616 2908 6672 8243 9126 2033 10735 8370 8517 5885 10274 57591 7508 10401 6256 6996 4306 5914 3065 25942 197370 1029 493861 7181 9656 286053 23137 6095 79677 56160 54780 8648 7376 5905 51564 9612 10891 8204 9189 8924 332 8535 4152 55143 6304 6294 7341 10210 6045 9994 1107 7022 115426 83746 4929 7690 648 5610 7021 8554 10521 3619 6015 7329 3066 23468 9759 1912 2516 1911 9212 23512 23314 80012 57332 84733 10155 6612 7703 6613 59348 367 4791 7428 3622 7155 7150 8021 4193 165918 1069 7158 7486 7068 10499 51602 672 5893 1387 4286 4792 5111 1789 1788 641 1786 6117 11315 7153 28996 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-264642.6 Acetylcholine Neurotransmitter Release Cycle 8541 8497 8499 1103 6844 22999 8500 10497 10815 60482 5864 6616 6857 6572 9256 6804 RETINOID METABOLISM DISEASE EVENTS%REACTOME%R-HSA-6809583.3 Retinoid metabolism disease events 5950 WAX AND PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-8848584.5 Wax and plasmalogen biosynthesis 8443 158833 8540 55711 84188 25979 158835 TAT-MEDIATED HIV ELONGATION ARREST AND RECOVERY%REACTOME DATABASE ID RELEASE 95%167243 Tat-mediated HIV elongation arrest and recovery 6829 2963 2962 5434 5435 5436 5437 5438 5439 8178 25920 5430 5431 51224 5432 6924 5433 7936 6827 6749 9150 6917 1025 51497 7469 11198 904 6921 6923 5440 5441 RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT%REACTOME DATABASE ID RELEASE 95%444411 Rhesus glycoproteins mediate ammonium transport 6005 57127 51458 INTESTINAL INFECTIOUS DISEASES%REACTOME%R-HSA-8942233.2 Intestinal infectious diseases 2984 79849 RHOJ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013409 RHOJ GTPase cycle 11135 8874 4952 5295 5296 55004 9497 23048 54874 57381 7454 2631 2697 2040 8773 6510 147179 2909 9743 57584 392 9341 394 5062 9815 7879 5063 10298 55240 81839 23092 91010 3728 144402 85360 8976 8476 81704 998 7204 143098 11060 57580 4983 9578 857 23513 55789 128239 7112 7037 5058 28964 200894 81624 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%R-HSA-5173214.3 O-glycosylation of TSR domain-containing proteins 92949 170691 7057 145173 57188 10417 10418 170689 171019 54437 9510 9037 5199 7058 157869 9507 140766 80070 9508 9509 339366 221981 79875 81794 55901 81792 9719 56999 11173 11096 11095 11174 80731 23275 170690 54507 11093 170692 DISEASES OF TELOMERE MAINTENANCE%REACTOME%R-HSA-9673013.3 Diseases of Telomere Maintenance 1616 546 INTEGRATION OF VIRAL DNA INTO HOST GENOMIC DNA%REACTOME%R-HSA-175567.4 Integration of viral DNA into host genomic DNA 3159 11168 8815 MET ACTIVATES RAP1 AND RAC1%REACTOME DATABASE ID RELEASE 95%8875555 MET activates RAP1 and RAC1 5879 4233 2549 2889 5906 1399 5908 85440 1398 3082 DARPP-32 EVENTS%REACTOME DATABASE ID RELEASE 95%180024 DARPP-32 events 5534 5515 5516 84152 808 5518 5566 1020 5567 5530 5499 5141 5568 5143 5532 5144 5528 5573 5533 5575 5576 5519 5577 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1250196.6 SHC1 events in ERBB2 signaling 2064 1950 1956 9542 10718 145957 5580 3084 685 5782 2069 5578 1839 6464 6654 5581 4893 3265 MPS IX - NATOWICZ SYNDROME (CS DS DEGRADATION)%REACTOME DATABASE ID RELEASE 95%9953097 MPS IX - Natowicz syndrome (CS DS degradation) 3373 CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER%REACTOME DATABASE ID RELEASE 95%5674400 Constitutive Signaling by AKT1 E17K in Cancer 253260 55615 572 2931 64223 207 4303 1026 84335 2475 7249 208 2932 1027 10000 2309 6199 842 3164 79109 1147 2308 5170 4193 HATS ACETYLATE HISTONES%REACTOME%R-HSA-3214847.3 HATs acetylate histones 23326 11091 84289 60 6881 57634 7862 10474 5931 221613 8850 8295 92815 8969 8607 440689 3054 23774 6314 8970 8331 2648 8337 128312 8334 8335 64769 2033 8370 10445 8968 8341 8342 8347 8348 1386 51230 8345 3013 8340 27097 8338 55578 255626 9767 9643 653604 3018 3017 117143 11143 85236 6944 8464 55929 5077 8349 55250 27154 55257 10629 26610 23587 55140 54859 55167 10933 8648 23338 10943 56943 9913 51147 23522 54556 56970 6880 55683 6883 79960 55689 10902 339287 8520 8518 54934 1810 51562 10856 8089 7994 79595 57325 84148 6871 284058 10499 9575 93624 1387 80314 8473 317772 85235 26009 10524 112869 86 CALMODULIN INDUCED EVENTS%REACTOME DATABASE ID RELEASE 95%111933 Calmodulin induced events 113 114 115 107 108 109 196883 5566 5567 5568 5153 5573 5575 5576 5577 5582 5613 156 3838 5137 10645 26960 84254 814 808 5580 5136 815 5578 816 817 818 111 112 IRS ACTIVATION%REACTOME DATABASE ID RELEASE 95%74713 IRS activation 3630 3667 3643 8660 2887 ACTIVATION OF RAS IN B CELLS%REACTOME DATABASE ID RELEASE 95%1169092 Activation of RAS in B cells 10125 25780 4893 3265 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 95%418594 G alpha (i) signalling events 113 114 5332 115 50840 2774 301 107 129521 108 109 196883 3827 5566 5567 5568 5367 3710 10316 6753 5153 26575 5473 84539 729230 5321 5136 719 2847 8698 57121 2778 9170 3708 23566 3709 9294 4852 727 728 1903 1902 53637 1235 1129 1132 5499 5533 5573 5575 5576 5577 5613 5534 5330 5331 5530 5532 150 2780 23236 3361 151 152 59340 165140 3355 1815 1814 3354 3352 3351 2781 5956 11251 5733 5580 2357 4986 4988 5578 3579 3577 1020 5726 2793 2792 2791 2790 5582 156 3838 5137 2788 10645 10768 2787 26960 2786 10636 84254 2785 26086 84152 2784 85397 2783 8601 51764 126006 5141 5143 5144 6001 6002 9560 9630 94235 26166 6000 6750 8787 29899 8786 718 259289 63940 259287 259286 259285 55970 9628 183 259293 259292 259290 54331 259296 2767 259295 59345 5443 2769 2652 2782 2776 10681 2919 6010 54429 2779 80835 80834 5196 221391 611 5995 10692 23596 5594 51083 56670 338398 4987 27198 27199 2550 6288 2587 4886 6351 4887 6352 4889 58191 6357 2359 1269 1268 2826 10850 4543 6364 4544 6363 259294 6366 353164 1230 6751 6360 5540 6752 2833 5539 643 10663 6373 338442 6372 6755 6374 10022 6376 6754 6370 8811 346562 339403 5519 2921 57007 2920 8843 1237 5697 1236 256933 1233 3576 1232 51289 56477 8862 4283 6387 5515 6346 5516 10803 808 5518 10563 3627 5368 117579 5173 815 7852 1234 9568 5528 2771 6714 2770 816 1524 431704 2918 817 2917 818 2916 2913 6003 2912 2773 8484 186 6004 187 50835 2832 2831 1880 283869 2841 2914 2853 2852 50865 10874 2861 9283 9290 1325 64407 2358 846 4985 5996 5998 5999 814 351 5030 623 53829 624 140 10287 83756 64805 134 56923 8490 9934 50831 50833 50832 50834 5179 50837 353299 50836 50839 50838 5660 111 112 2840 NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME%R-HSA-112313.5 Neurotransmitter uptake and metabolism In glial cells 6506 6507 2752 81539 SYNTHESIS OF KETONE BODIES%REACTOME%R-HSA-77111.7 Synthesis of Ketone Bodies 622 3158 65985 3155 79611 56898 38 54511 VPR-MEDIATED NUCLEAR IMPORT OF PICS%REACTOME%R-HSA-180910.4 Vpr-mediated nuclear import of PICs 23636 9631 7175 9972 11097 23279 8086 23511 53371 8480 79023 79902 10762 8815 5903 348995 9883 6396 129401 9688 57122 23225 3836 4927 3159 23165 11168 55746 8021 55706 ERYTHROPOIETIN ACTIVATES PHOSPHOLIPASE C GAMMA (PLCG)%REACTOME%R-HSA-9027277.3 Erythropoietin activates Phospholipase C gamma (PLCG) 2056 4067 5335 8660 5336 3717 2057 DEFECTIVE F8 ACCELERATES DISSOCIATION OF THE A2 DOMAIN%REACTOME%R-HSA-9672387.2 Defective F8 accelerates dissociation of the A2 domain 2157 ACTIVATION OF RRNA EXPRESSION BY ERCC6 (CSB) AND EHMT2 (G9A)%REACTOME%R-HSA-427389.3 Activation of rRNA Expression by ERCC6 (CSB) and EHMT2 (G9a) 57504 474382 57459 9112 3065 54145 54815 7270 53615 5928 10919 8970 8331 8337 128312 8334 8335 1107 8370 55766 8968 5931 3066 2074 8341 8342 8347 8348 11335 94239 8345 3013 8340 8338 255626 3021 653604 3018 3017 85236 3014 1108 8349 9219 HISTIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 95%70921 Histidine catabolism 131669 3067 3034 138199 10841 3176 144193 57571 MITOCHONDRIAL UNFOLDED PROTEIN RESPONSE (UPRMT)%REACTOME%R-HSA-9841251.1 Mitochondrial unfolded protein response (UPRmt) 3301 3313 1670 847 3329 207 4899 27429 3304 2099 23410 3297 9361 2309 3336 6648 22809 DEFECTIVE SLC35A1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME DATABASE ID RELEASE 95%5663020 Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) 10559 INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 95%880009 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate 728294 79944 137872 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%R-HSA-2980766.4 Nuclear Envelope Breakdown 23636 9631 7175 9972 11097 23279 8086 23511 4001 53371 8480 79023 891 79902 10762 983 8815 64900 5903 5347 23175 5579 2010 255919 348995 9883 6396 129401 9133 9688 140609 91754 7443 10783 57122 5578 23225 4927 9663 23592 23165 221496 55746 8021 55706 S PHASE%REACTOME%R-HSA-69242.5 S Phase 91750 993 132660 7465 286826 55957 5928 5934 23649 5422 5557 5558 7027 1019 10714 5424 898 5425 57804 5981 51343 6502 3978 9134 56655 1027 4149 7029 1869 5925 5426 8243 5427 9126 23244 23047 10735 23063 5885 10274 54107 208 5753 595 1017 994 1026 64785 8318 1875 9837 1874 84296 51659 2237 4609 9861 6233 9978 2932 7316 10213 4331 51529 7321 1022 5706 8881 64682 5707 25906 5708 11065 5709 8697 7324 10393 29945 27338 207 119504 5700 5701 29882 5702 246184 996 5704 51434 5705 51433 5682 5683 5684 5982 5685 902 5686 5983 5717 5718 5719 91768 11047 5713 5714 5690 5691 5692 5693 5694 1163 7311 7979 5695 5111 7314 157570 4172 8454 4173 4174 5687 4175 113130 5688 4176 4171 114799 5689 990 1763 84515 51053 6117 10000 5000 5984 5001 890 5985 6119 8900 6500 23595 6118 23594 81620 4998 4999 DEFECTIVE ALG14 CAUSES ALG14-CMS%REACTOME DATABASE ID RELEASE 95%5633231 Defective ALG14 causes ALG14-CMS 199857 79868 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME%R-HSA-381070.3 IRE1alpha activates chaperones 5611 84447 3309 9695 6464 22872 2137 10525 2135 2931 27230 118 5526 100137049 51726 37 2673 7094 9820 10130 3068 55062 10954 58477 6745 9114 10113 10897 4000 9797 7466 4189 116138 9570 6818 7709 56005 10106 2081 55033 1663 1200 2134 6734 64061 11015 55738 30827 1639 MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 95%5389840 Mitochondrial translation elongation 6150 55168 64949 28973 65080 51642 54998 5018 10573 11222 128308 51649 9553 64960 92259 64963 63875 64965 64968 55052 55173 64969 51373 26284 51650 51253 60488 51258 219927 29074 56945 28998 64975 79590 64976 64979 64978 23107 28957 64928 7818 51263 29088 51021 57129 54534 51023 7284 51264 51069 84545 78988 122704 65993 64981 10240 64983 3396 63931 26589 54460 6182 6183 118487 51073 116540 740 124995 54148 116541 55037 29093 9801 51116 10884 54948 51318 85476 10102 64432 65003 64951 65005 65008 28977 90480 51081 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 95%69541 Stabilization of p53 5706 5707 5708 5709 1029 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 472 5719 11047 5713 7157 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 9861 51230 6233 5687 5688 5689 7316 11200 4194 10213 64326 4193 DEFECTIVE GNE CAUSES SIALURIA, NK AND IBM2%REACTOME DATABASE ID RELEASE 95%4085011 Defective GNE causes sialuria, NK and IBM2 10020 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME%R-HSA-373080.4 Class B 2 (Secretin family receptors) 799 79924 3375 1394 10266 1393 10268 2695 10267 55970 10203 6608 5744 5745 5746 5727 2015 54331 59345 2642 51384 2641 8321 8325 116 7471 117 2782 11211 114131 8643 10681 7473 7479 30817 7478 113091 7349 7472 7475 7477 2778 8326 7476 7482 976 1604 2692 2691 9340 2740 7433 3549 7483 6344 7432 89780 6343 7434 2696 2793 2792 2791 7484 2790 7480 7481 84658 2788 2787 2786 1392 54361 7976 2785 7855 2784 8322 2783 51764 8323 2535 90226 7474 8324 6469 94235 50846 5741 80326 133 796 797 INTRA-GOLGI TRAFFIC%REACTOME DATABASE ID RELEASE 95%6811438 Intra-Golgi traffic 83548 27333 63908 10905 57511 10466 9827 9321 8675 10652 4124 250 84342 54734 91949 83452 4121 4905 4122 27314 51272 1523 9609 57134 9527 9267 11311 9265 9266 22796 9570 9382 6811 347517 8774 8775 27128 57589 9950 25839 143187 9342 10228 375 MITOCHONDRIAL ABC TRANSPORTERS%REACTOME%R-HSA-1369007.2 Mitochondrial ABC transporters 22 10058 11194 23456 O-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 95%5173105 O-linked glycosylation 84002 9334 9331 56667 10331 11093 145173 57188 2591 143662 79695 10417 9486 118430 11041 10418 9215 170689 29954 171019 113829 729920 54437 120071 9510 2218 9037 4582 146664 5199 10329 4583 79147 7058 148789 4584 84892 4585 10585 4586 55624 200958 1605 157869 84197 727897 29071 9507 140766 80070 9508 9509 10071 94025 339366 221981 79875 81794 140453 55901 4588 4589 81792 283463 9719 56999 56913 394263 11173 11096 11095 11174 80731 170690 54507 170692 92949 170691 8693 55568 442117 374907 11227 11226 374378 51809 64409 84752 140687 9245 114805 2650 168391 192134 63917 51146 146712 117248 51301 2590 26290 50614 57452 79623 10164 10610 6483 6482 6484 6487 23275 7057 6480 79812 256435 129080 84750 170384 27090 93010 10678 79369 10559 22915 2589 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 95%597592 Post-translational protein modification 10618 164395 5611 80235 9487 3956 9488 4924 91445 3053 146760 7070 6048 26140 721 50863 11091 8614 51715 2519 84628 375056 23093 10272 84871 174 646627 1435 123624 10956 54972 3698 387787 2653 84141 9210 5929 340351 11098 57403 462 257194 1368 54587 401409 7425 58530 10966 284348 154064 390243 79805 7512 266727 55647 353091 25837 8729 137797 79841 55650 51299 23627 5931 25809 4045 91978 116372 4062 115273 23170 4706 8434 374969 142684 378 7369 254173 171169 54965 51227 8766 8000 54742 123904 60509 84720 966 83871 57111 10942 147719 83639 1604 83887 51601 84992 8073 1121 5864 4869 5970 8451 8533 9486 11041 9215 64708 29954 113829 729920 120071 2218 7334 146664 10329 7336 10987 79147 148789 10980 84892 10585 55624 1605 50813 84197 83475 64122 1984 23463 10920 79672 1642 56648 1725 7508 10401 3569 55860 51164 830 10671 1639 4306 93661 84516 8878 10890 4221 2215 7341 7022 7021 7329 5870 8453 7323 7322 2034 9978 3091 6921 6923 5869 22931 64344 7428 5878 1075 113457 7280 26272 29099 5329 5111 26234 6468 10376 26190 23412 683 26270 8876 10381 10383 6696 10382 55294 112714 326624 60 7846 84790 5371 84617 10238 10517 10342 84261 347733 401258 7278 7157 9545 26224 81027 11031 2804 54461 348995 9883 6396 129401 9688 57122 23225 55832 4927 23165 55746 55706 23636 9631 7175 9972 11097 23279 8086 23511 53371 8480 79023 79902 142 10762 1522 5903 8655 2908 58485 991 2517 53916 53917 1315 57591 51143 387 10196 1781 1780 1778 7181 6095 5905 1783 332 55143 4929 3619 140735 2516 9212 59348 4791 3622 2266 286 93010 2243 10678 8703 8704 8702 79369 2677 2159 2621 2147 2158 2155 8858 5624 5627 1629 8454 338328 51128 255738 890 8900 6500 5034 116519 213 335 336 8720 154881 7320 22872 51088 9616 7317 7319 3093 8835 9871 9306 9632 9641 150726 10427 118424 55336 7327 7326 3913 8945 3915 7328 2335 11093 54926 65264 9112 93611 3912 127247 401036 79791 811 51665 51666 142686 6194 142685 55236 51676 5720 142689 6228 1915 80204 57542 6187 9554 23014 25793 11275 84864 64410 23210 222235 54850 140456 140458 140459 2923 90135 146330 140460 140461 140462 54620 115290 7704 55958 8139 390594 55284 84961 997 8924 122769 10670 55175 27252 51130 9903 92369 5537 64326 126433 79090 26259 22870 11070 9117 11196 201456 254263 144699 81562 1453 27095 899 84861 149111 92912 9919 10477 165918 89866 7109 5696 4253 6399 26268 79694 2348 7879 23243 90293 10175 84727 1069 126003 92591 25956 26263 10802 55014 10652 51693 7158 122553 3998 26267 10484 10540 64377 53339 2525 10489 83696 285231 90411 89890 10282 26984 9820 79748 55291 128637 26235 26118 10960 79176 26232 5893 5698 5699 84085 4008 51725 9039 26249 8065 84078 10121 140739 9040 11258 79754 84541 80176 136371 10324 25879 2589 7046 7048 7040 8459 8460 7184 7518 10331 26286 6157 3895 444 57719 1487 6132 84364 8243 9126 10735 5885 10274 92305 6596 23168 9781 56852 79577 51322 5591 80349 123169 51255 9646 257218 55829 9810 220441 6996 54623 8915 3371 4148 1758 9189 8535 6304 6045 1107 83746 5610 648 8554 6015 3066 23468 9759 1912 1911 23512 23314 80012 57332 84733 6612 7703 6613 8312 324 139285 4248 2107 57104 10499 10055 25950 10054 374 4780 90268 29089 1387 4286 81876 5861 5862 64689 7039 1789 1788 1786 8615 347688 7153 84002 260334 285362 79642 25870 340075 410 412 414 415 416 9334 22901 10959 9331 153642 347527 338 10537 55208 7332 10072 28952 23142 26094 54939 9655 2350 23038 140825 23369 54951 2230 23363 1154 54165 149951 1161 80344 55827 23113 84259 6709 56929 79016 51122 5867 54876 50717 9146 83987 26043 150684 5868 8816 90864 170622 10116 79269 51397 55884 55527 56995 28991 80067 55666 123879 8883 122416 10113 9570 11015 55738 102 84061 11282 7841 80028 23194 55741 1650 11320 4247 100128731 91433 4249 100137047 6185 79697 7991 4124 55854 79831 4245 6184 1819 51389 25834 4733 1048 23193 58505 55239 65094 201595 8875 6383 2530 821 11253 5589 746 1603 3703 2719 9986 6478 100287238 100287478 81847 51762 23682 9738 8767 9736 57506 728386 161725 4738 9230 23172 367 51651 9868 8658 93973 4194 9363 8314 7345 8678 7347 8313 4193 375 338382 57646 84101 4086 63891 7353 201475 4087 1122 4088 100287327 4089 11021 100287205 55593 9099 5872 9097 100287441 5728 23032 116442 64750 114785 248 23011 100288520 114548 10981 4092 5721 154 10617 7375 392188 829 93624 11274 55252 377 5071 10868 57559 10869 23252 7128 89122 8473 4792 10392 317772 23586 79594 51552 79913 85235 4303 54617 84142 92552 9577 100287404 221937 64426 55031 23358 83844 123228 11315 57695 79589 5886 84132 4798 5887 8239 10600 86 7706 9100 9101 51588 25862 100287513 27005 23326 80124 55288 993 79931 401447 10254 84282 645836 6881 6885 8027 125476 55611 54764 51377 57599 5423 408 80351 409 1080 7187 7186 94005 7189 56667 80055 79155 100287178 8733 10026 29761 54891 128869 10474 51604 29086 56957 7874 221613 1643 9804 9929 171023 8850 6811 645402 8975 8295 151194 832 2625 22944 79091 51720 10970 92815 399818 8724 254013 10454 221143 6711 8969 196483 8607 79609 9817 219333 440689 64127 3054 100287144 84749 78990 126119 55777 23770 1540 8737 6314 329 91833 7528 3607 51616 84196 9960 8078 64135 377630 2099 29844 728419 63967 114803 330 10318 7415 9958 7417 7416 7419 2648 4287 79184 100287364 55432 283899 3972 83444 3630 27430 8517 10445 26958 8774 8775 23256 10945 63908 8074 51014 57511 3416 1000 339122 23423 372 5873 84342 91949 4121 8693 55568 4122 442117 381 374907 11227 11226 374378 51272 51809 64409 57134 84752 140687 9245 114805 2650 9527 168391 192134 63917 51146 146712 808 22796 117248 51301 2590 29843 26290 50614 2890 9382 51560 57452 79623 347517 10164 10972 25839 9276 7321 11316 83548 11065 7324 10905 1737 10466 27338 22818 983 1314 54732 23291 7486 4218 54734 51226 83452 27314 22820 672 11014 9609 5265 22915 2153 7979 351 197 580 641 6117 2157 79728 135228 813 6708 7076 6710 6712 3827 143471 389362 56984 51371 11338 80227 122706 5710 10197 5711 8624 5715 5716 84262 9491 29106 23198 1655 6694 334 5874 7018 1294 5768 57731 6670 3090 287 668 288 51332 80341 2801 2683 51514 3190 4061 4052 652 2200 3065 25942 1029 5828 1026 51399 10891 4609 9861 6233 3312 7316 10213 8021 5706 5707 5708 5709 5195 5700 5701 5702 5192 5193 5194 5704 5705 5682 5683 5684 5685 5686 5717 2109 5718 5719 11047 5713 5714 5690 5691 5692 5693 5694 7311 5695 7314 5687 5688 5875 5876 5689 3486 79644 3484 632 718 5045 90865 1743 8452 3183 56254 2873 3105 51138 9318 1081 1462 6790 5465 5987 411 2720 5468 79823 5241 7421 145173 57188 2591 200845 143662 79695 10417 6502 118430 1616 10418 170689 171019 54437 9510 9037 4582 8970 5199 4583 8331 7058 6672 4584 8337 4585 128312 4586 8334 8335 200958 157869 727897 2033 29071 8370 9507 140766 80070 9508 9509 8341 10071 94025 8342 8347 339366 221981 8348 79875 8345 81794 3013 140453 55901 4588 8340 4589 81792 8338 283463 255626 9719 56999 6256 56913 394263 11173 3018 11096 3017 11095 11174 85236 80731 170690 54507 170692 8349 92949 5914 170691 89978 92715 197370 493861 9656 1938 286053 51611 285381 23137 120526 79677 56160 1802 54780 1801 9761 8648 64772 80267 84447 10299 55768 9695 10206 7376 9612 56886 51564 267 4905 51035 8204 7844 55757 11236 221656 4152 6294 10210 9994 115426 7690 10521 348 140838 29906 207063 6675 124872 56052 81849 10155 440138 79053 84920 51046 5973 51005 10610 6483 22845 6482 6484 51209 114907 55808 6487 7155 6489 7150 64841 23275 5476 9367 10020 3098 79087 256281 7057 6480 144245 256435 79812 10825 129080 55577 84750 2673 170384 115827 8813 64284 27090 4978 30815 22854 9945 503542 85365 27076 197258 22846 8818 57799 7264 5865 29929 376267 4351 1043 10195 7068 80328 4597 205564 338596 84932 59343 6975 8790 51602 146183 29926 54872 29925 55343 8934 84276 29880 161357 1798 10130 79796 1087 419 10559 23556 84620 54757 79139 420 51246 2762 150465 91869 8404 349667 8542 51009 8869 1471 25941 5238 3491 432 116150 3490 433 6400 5372 79739 5373 3488 158135 55907 3487 284098 8128 9021 80740 7466 57171 284076 64856 26503 349633 282969 10117 23287 199857 53942 1114 54187 152330 258 80896 7857 5277 54344 5279 79868 11167 10232 249 9526 79947 5283 5954 130576 1356 7903 56955 4758 251 4240 10402 5281 4241 129807 9654 5179 4759 3270 5067 265 54839 93183 401138 51156 8581 91851 7007 360226 11019 28996 147111 2813 51280 27247 56975 2822 NTRK3 AS A DEPENDENCE RECEPTOR%REACTOME DATABASE ID RELEASE 95%9603505 NTRK3 as a dependence receptor 25920 581 4916 DEFECTIVE NTHL1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 95%9630221 Defective NTHL1 substrate processing 4913 RESPIRATORY SYNCYTIAL VIRUS GENOME REPLICATION%REACTOME%R-HSA-9834752.1 Respiratory syncytial virus genome replication 3320 3326 DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS DUE TO P14ARF LOSS OF FUNCTION%REACTOME%R-HSA-9645722.3 Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function 708 1029 G1 PHASE%REACTOME%R-HSA-69236.6 G1 Phase 7027 1029 1021 595 1019 1017 894 896 1871 1026 898 1875 1870 1874 6502 28227 9134 1028 1027 902 7029 1869 5925 5520 5519 1030 1032 1031 1163 5933 5515 7311 5934 5516 7314 5518 8454 6233 4067 7316 5753 6500 25 4331 1022 3717 BLOOD GROUP SYSTEMS BIOSYNTHESIS%REACTOME%R-HSA-9033658.3 Blood group systems biosynthesis 28 30815 124872 2524 8707 6007 2523 6006 8708 10690 2525 10402 2526 10317 8705 2529 2528 6484 2527 6487 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN DNA REPLICATION, DAMAGE REPAIR AND SENESCENCE%REACTOME%R-HSA-9825895.3 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence 4171 3978 7015 672 4174 IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME%R-HSA-6788467.5 IL-6-type cytokine receptor ligand interactions 3716 386653 3976 1489 5008 3572 3977 1271 1270 7297 3590 3589 23529 9180 133396 9244 3717 SIGNALING PATHWAYS%REACTOME%R-HSA-162582.13 Signaling Pathways 553 554 50840 10956 6753 2847 5584 100996717 51548 1999 100996763 388677 90780 57680 9580 56998 283149 83595 64321 25776 26108 55553 6658 607 6736 6659 7204 23463 9500 55160 23365 9181 128272 57580 4804 10018 26230 121512 1894 10451 7410 84904 100271715 26084 23370 25791 89846 9826 3337 54848 9828 7409 2288 23229 22899 50649 8997 6453 7984 29 8874 64857 10728 572 57449 8651 389337 445328 2245 23263 3551 50650 8878 26574 4615 221472 5599 9639 10672 10276 55701 5879 9459 9138 4168 27237 7074 6655 11214 5924 1592 340665 56603 51741 2242 23396 7323 7322 2034 7473 7479 7478 9978 51339 3091 59349 23072 440193 7428 5440 5441 2963 2962 5434 5435 5436 5437 5438 5439 5430 5431 5432 5433 908 2793 2792 2791 1460 2790 1459 2788 1457 2787 2786 2785 2784 2783 51764 10376 9630 94235 6000 8787 8786 55970 402 9628 60 161742 4763 22808 54331 399473 11221 2767 59345 200734 2769 7157 64840 2782 54845 2776 1852 10681 1850 8877 8036 348995 6396 57122 1003 55746 23279 8086 79023 79902 5903 54908 6232 8655 23768 25909 23769 53834 8379 9183 50937 91653 1063 1062 132884 2121 91010 9184 23288 1060 2622 84455 1855 2619 991 151648 55166 752 1058 79019 998 151246 9735 1857 1856 23332 57591 79003 55055 81565 22919 348235 5048 23421 220134 57082 23380 57405 51143 147841 4085 64105 401541 10403 387 81624 1147 388 389 54820 80776 701 54821 378708 286205 1781 23122 1780 23002 79172 1778 81930 9110 55920 84643 114793 29984 3796 5216 5217 9793 91687 5583 9162 57551 8527 79682 5905 26090 8525 1783 8526 5501 3688 57406 221955 83540 160851 80152 2491 1609 5519 747 332 1608 55143 1607 699 1606 6722 139189 11243 51466 71 3619 140735 5515 11004 5516 5518 9212 25936 11130 64946 79980 10726 1729 5525 5526 55839 5527 5528 5529 7422 2324 2768 3791 7424 7423 2277 2321 5228 29126 3561 23189 6801 5607 8828 112724 10170 9249 8854 64577 22916 25920 1382 4686 1381 57665 216 8608 51109 7185 8644 10399 157506 220 1025 124 126 127 195814 904 4985 7484 28514 182 54361 10434 3625 3955 3624 3623 2488 8454 25805 56937 29924 11171 58513 10252 5087 9148 5774 5796 9787 54492 171558 23286 142678 26508 10460 388585 6500 57534 3718 5336 30011 4916 4908 5894 23186 5906 5908 5566 5567 11069 5568 10411 10800 10235 10125 4628 79784 4629 3984 3985 103910 4637 4627 130399 91 92 7222 93 8928 10589 10468 7225 57113 8555 3913 8682 3914 3915 8437 2335 10642 10319 221002 7010 3918 284217 284 2118 3908 5863 3909 10193 152559 51104 3910 10156 3911 9693 3912 1129 22821 1128 115727 1133 1844 1132 1843 1131 153090 989 1847 5896 5897 54756 8831 84292 57139 81926 5596 5597 64926 6194 58489 5922 10616 3178 4851 4853 4854 4855 165140 120892 5753 1839 10457 8887 23221 29766 55023 7919 5756 124540 3326 87 51719 6198 5562 5563 6794 7248 5564 5565 389541 29904 81610 28956 1975 389658 57521 143282 80310 55004 10608 8649 5764 51422 23543 10670 6009 5327 1978 558 1977 285016 5494 6461 5571 57610 64121 9982 64223 4058 382 92335 11033 153129 10188 2280 81617 55824 80004 84335 7059 53632 2475 3925 7249 7060 84985 55437 7073 58528 7072 10542 10325 83888 9047 8773 50508 1447 7444 5800 6510 5803 2909 9743 57584 392 9341 394 5062 395 1536 10811 397 1535 10458 55843 10979 9815 7879 55845 4688 4689 10298 10652 3998 9235 9710 81839 10489 23092 55971 143872 347902 1829 4810 55619 85360 8936 10424 10787 5881 27 10152 64411 124056 2010 23344 143098 8065 84078 2889 29127 4983 613 9040 857 8987 3930 55789 51347 26050 3071 4162 7112 7037 5058 10163 28964 80728 22865 80824 23191 653361 23592 23075 116984 133 55114 796 27035 797 799 11135 79924 4952 1969 3375 10266 261734 10006 10268 55914 10267 7046 10203 7048 7040 4001 4296 1284 1282 10928 115557 23048 26030 80243 54874 79658 83478 7454 9754 7456 115703 2040 8405 139818 201176 10788 57514 51133 26286 9901 64333 9644 6925 116985 4617 23268 4618 147179 57480 117289 57522 4654 3895 4656 9912 50855 51306 64399 22873 8826 343578 25989 57758 9411 50619 339745 221178 85455 101059918 124997 58504 257106 4158 1123 23526 5063 4650 153478 57144 644150 393 55240 396 398 84364 5337 29062 148170 51291 3728 144402 8976 84888 85440 25999 90627 8439 56928 8476 56990 81704 23348 89839 57569 23580 611 221391 10395 5995 10435 10692 92799 10160 23596 9578 25894 79577 57572 23513 10602 128239 56924 123169 3690 3640 4684 51083 3685 90226 3674 1240 56670 3678 338398 170589 8829 4987 5604 55733 3792 6469 5605 27198 50846 27199 7043 5741 6285 80326 7042 6288 2587 1299 1298 4886 4887 3693 51135 4889 122042 3694 1394 1393 2359 1269 1268 6678 5744 5745 5746 2492 4543 4544 259294 2015 257397 23118 353164 6751 5540 6752 466 5539 116512 5054 338442 3673 6755 7867 1297 10022 6754 8516 8811 339403 51384 5802 151306 8535 8843 5697 6045 256933 1107 7504 11211 648 51289 4142 6015 8862 3066 51052 4157 114131 9759 1912 9718 4161 1911 23512 8643 4160 80012 5368 57332 4159 30817 84733 117579 113091 5173 8312 7472 2932 7475 324 7477 1452 8326 139285 7476 6019 1524 7482 7253 2918 2917 2916 2913 2912 8484 186 187 50835 2834 2832 2831 122876 1880 283869 2841 57486 2853 2852 2859 50865 1889 2861 9283 3973 9290 59350 1325 2532 374 596 598 1387 6667 5777 6870 6863 6865 6866 6869 814 4915 4909 627 7039 2353 685 127933 255324 2069 2002 10000 2309 8556 5747 7474 8324 3725 111 112 113 114 115 2774 107 108 109 196883 5739 5138 1455 3710 4846 5153 5593 487 488 489 5321 5136 2778 10846 3708 3709 50940 5867 9146 9350 5598 51231 1849 1848 1846 1845 51125 51114 5729 11251 5731 5732 5733 5734 5737 6915 9986 81847 9738 8767 9736 4738 367 8658 8313 4193 4086 4087 4088 4089 9099 23179 5728 64750 4092 154 7375 23252 7128 4792 10636 10888 5293 26086 84152 85397 8601 126006 4303 8622 5141 5143 5144 5139 5151 6001 6002 5150 157 9560 11245 11250 285601 26166 2838 2843 2848 8239 29899 27115 2854 2850 2870 9101 63940 27005 55288 183 10254 268 6885 9241 8027 54764 51377 408 80351 409 1080 7186 7189 56957 7874 8850 8975 8295 2625 8724 10454 8607 8394 8395 1540 8737 329 7528 377630 2099 330 7415 9958 2648 3972 8517 1152 51072 1495 1500 6615 7015 7391 5725 7852 1234 5020 5500 4295 7200 5021 7201 431704 4670 56413 22938 5031 5032 6003 1909 1908 6004 94233 2798 2797 2796 1907 5028 1906 84432 5029 6375 1241 2693 1910 84109 10874 29933 222545 10887 5724 10886 257313 64407 387129 2911 2358 846 2915 8111 8477 2922 5996 5997 5998 5999 2925 6846 10161 185 623 624 4314 10287 56923 8490 2151 2150 57105 2149 2829 2828 353299 885 886 887 2837 347148 9002 338557 3814 10911 2840 2846 4904 5332 594857 64106 301 166 129521 51699 128674 9559 2867 55737 79971 2865 2863 50999 2862 60675 4922 4923 2869 8620 680 27334 84634 3060 5367 23620 3062 3061 10316 4828 4829 2642 2641 26575 2520 1655 84539 1286 1285 256076 131873 1293 1292 1291 3187 1287 3185 83855 3070 2683 6692 3249 10653 5499 3083 23509 56983 3815 9287 3363 3362 150 3361 151 3360 152 59340 153 155 3358 3357 3356 3355 1816 83551 1815 1814 1813 1812 134864 319100 134860 9038 3354 3352 3274 3351 3350 146 147 148 3269 11255 4935 11108 6908 27018 8837 2308 10413 4638 6929 3654 4986 4988 2100 6938 9765 4090 1020 4093 657 658 659 94 64388 2658 269 835 1030 1024 843 4790 1278 864 79109 6750 23327 2146 10013 639 10014 10498 6772 5443 1081 650 892 3276 3280 8726 55534 5467 5468 5469 5241 2591 200845 25937 7058 200958 6597 84441 8795 8550 8793 8797 6456 6455 2060 6457 54815 11059 84447 92597 9113 154810 26524 55233 51564 51421 60485 6788 6789 23493 144165 1212 4920 8321 8325 7471 81029 4919 6259 23466 66008 22836 4771 3798 3799 4660 23462 2017 54763 10398 9927 10109 55669 10552 10093 10092 10095 10094 2810 10097 51592 10096 64837 354 51209 94274 89953 89941 147700 9367 3817 9219 22906 23081 3831 7057 30851 5910 9055 80179 51517 83737 7050 3952 8396 7082 9021 60436 11167 3726 84870 5179 91851 147111 5915 5916 84661 11091 10272 5928 5929 7425 4313 1399 905 3516 5931 27202 5933 930 9070 79885 719 727 4852 728 1108 1604 83933 5970 3549 5782 5778 3562 3559 3558 10971 5978 5771 5979 26469 1392 57678 3569 1386 4485 4486 57459 4435 5300 995 4208 4221 55615 5305 8812 5870 2357 2289 55869 54778 3579 3577 79837 976 23439 6662 2064 4318 6657 5795 8851 3164 5579 7532 7531 7533 7525 5588 6696 6446 5371 9734 581 53831 355 356 2919 7101 25 6498 6497 6258 253260 9757 142 7077 53615 4091 2908 5196 9794 53916 84658 10273 84951 64759 10046 6351 6352 58191 6354 6357 6356 6348 6347 6349 2826 10850 6361 9034 6364 6363 1875 6366 1874 6367 1230 6360 2833 643 10663 6373 6372 6374 6376 6370 1238 2737 2921 57007 2736 2920 1237 1236 1233 3576 1232 56477 4283 6387 57154 6346 3845 10803 51554 10563 3627 5451 1437 8315 5245 3717 673 2244 2266 7414 8844 10256 6776 9402 54518 22866 4140 7450 5037 2243 7094 1445 369 283455 10817 2534 6850 3932 2147 1629 1738 1213 1211 5034 160 161 163 7166 6236 2152 3399 4066 8941 1175 1173 8061 3727 1785 3400 2354 10221 4664 4665 1959 1958 3398 3397 23237 1961 1960 429 7049 26018 10019 9306 2316 5829 9641 8650 9530 51684 8945 2735 57504 9112 4145 10755 3730 4040 22943 7483 4041 89780 6423 11197 6422 27121 79412 83999 27123 50964 5573 5575 5576 5577 5613 5145 4772 7481 5534 5592 5158 5148 7976 7855 51701 8322 5330 5331 5530 8323 5532 2780 23236 8471 2535 3480 8483 2775 23030 7088 7089 92737 8788 7091 1272 113878 1840 5956 1454 8481 23163 25780 118788 3563 3560 2885 1439 1438 3568 3567 6777 1488 1487 5536 50848 5590 57530 56288 8243 9126 7124 7480 10735 5885 5159 10274 6778 51523 9542 340481 10718 1105 145957 55625 7764 8290 7090 3169 5481 9166 9687 858 7033 7392 7031 4316 5147 200894 2173 2171 11343 10226 5166 8202 2494 10499 90268 1786 5660 1759 6610 4192 2208 59 5986 10959 4242 4099 57142 4974 84894 55512 116 117 5899 25759 6014 2931 6016 135 6300 5603 10126 53358 5900 4914 57498 26052 1398 8772 1395 7349 7332 2319 9414 2339 708 6709 841 1828 1832 3002 5533 10134 14 55075 8717 10211 8743 102 54567 5663 23385 55851 5664 83464 51107 136 2781 2262 6591 7252 4067 695 146850 5294 7006 23533 1215 10076 10750 2241 10603 3716 5898 59352 55366 7297 343637 340419 54894 8549 284654 84133 1072 10253 8569 238 5581 5582 156 3838 5137 10645 10768 26960 84254 6197 6196 9252 6195 4205 2057 2056 3675 23401 10023 2670 81858 2864 2695 6868 3714 5959 65124 55200 399693 253959 4722 23616 56667 57636 57630 55219 5825 64283 1362 22852 55227 26092 91544 1124 2697 10409 6811 91452 27289 832 23035 10970 4649 941 942 10505 2122 57679 6711 1822 5880 84232 114885 23239 79598 6199 3336 50852 284119 8870 27145 57167 4548 57579 57216 253980 10963 4690 5783 55968 54514 4580 55852 4698 11113 2692 2691 10144 25963 9340 79834 2740 2185 7433 6344 23433 667 7432 6343 79822 9928 7434 6793 2696 5585 5586 3163 54438 5338 157285 9938 23779 8502 5140 54443 9824 5781 4893 5361 245972 5364 245973 7535 8503 27006 9855 117145 3630 9732 155066 25813 224 2549 6472 9114 11180 51606 11060 8660 8776 5792 94240 5594 5595 29941 85415 30849 11188 10818 9550 84681 523 6242 8301 525 11075 526 527 120 1509 84317 208 9748 3643 23141 528 8440 8817 94134 9528 529 26281 7126 8992 390 9965 391 26999 5289 23129 6654 90423 399 222584 2254 3265 51566 2252 171177 127124 23256 2251 9322 23545 84144 55704 8074 70 51382 2802 3416 65992 2249 5099 2887 9217 2248 2247 55831 57761 51479 2246 54509 55717 533 2323 9462 10810 534 2322 1730 152831 80005 22800 535 537 93663 8823 26049 10312 9590 50617 57473 5295 7170 5296 9231 5770 7171 6464 123720 80115 2264 158747 9296 5290 57120 8153 5291 63916 5170 84986 2255 9846 9497 50618 54106 3667 157769 84612 114822 57381 3954 445582 808 58480 88 2631 29843 2886 3084 1795 1742 1794 1741 1793 152273 1740 2906 79180 23074 1739 23197 5162 815 5163 2904 5164 6714 5165 816 4747 2902 817 818 8050 5160 7321 5161 1737 10048 983 10133 5347 4659 1111 3082 3481 7979 5030 351 53829 3479 140 64805 134 9934 5155 10524 8408 2668 2676 2675 2674 6249 6708 7076 6710 5623 6712 3827 64096 6279 5786 5340 23767 5473 729230 6280 163404 57731 8698 57121 9170 9890 23566 64748 9294 54886 79948 1903 1902 1901 51332 53637 1235 1991 4902 9048 5156 2958 2957 4052 4054 2194 27302 3696 8425 4323 4325 6319 4233 8038 3065 25942 595 83439 1017 1026 1499 51176 6932 6934 23645 4609 4343 192669 23112 27327 999 26523 4613 220213 192670 27161 7132 55072 57690 9825 5580 9861 6233 9261 3315 7316 7514 5578 10213 7534 5706 5707 5708 5709 1981 207 5700 5701 5702 7529 5704 5705 10901 5682 5726 5683 5684 5685 5686 5717 5718 5719 1432 11047 5713 5714 5690 5691 5692 5693 5694 7311 5695 7314 5687 5688 5600 5689 331 842 7289 836 9742 23322 55081 55764 79659 374654 259289 8100 718 5045 80199 5046 51098 259287 5125 55811 259286 4803 79809 259285 26160 90865 9173 6608 11127 7431 57728 9475 23432 8452 27152 6434 8654 57539 259293 10250 54903 259292 9886 5727 9844 27316 23013 259290 9352 6093 3183 259296 11329 259295 56254 2873 79869 5930 940 10574 51138 9318 2652 10576 4646 1627 29110 23220 64130 5923 23608 5987 4734 2444 6010 54429 2342 11140 2779 3320 1950 5335 867 1956 7027 1019 896 1871 898 80835 80834 10657 27043 10656 1027 9564 7029 1796 55620 1869 6725 8970 6421 202559 8331 5921 8337 128312 8334 8335 2033 8370 55766 8968 4602 8341 8342 8347 8348 94239 8345 3013 3570 8340 8338 255626 6256 6774 3021 653604 3018 3017 85236 3014 2550 8349 5914 474382 2562 2561 2560 54145 861 865 6257 23028 9682 2554 2172 27329 6907 80820 8648 54659 79718 9619 64241 64240 7376 9612 10062 8204 2567 2566 8841 9611 19 346562 1071 221656 55879 341 344 29116 2874 346 347 348 5346 5105 10123 55818 9568 2771 2770 6484 6487 2773 4209 2914 551 27248 51009 6400 83756 50831 50833 50832 10402 50834 50837 50836 50839 50838 552 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression 6910 1482 8850 2626 7004 7003 7005 4878 204851 25937 8463 28996 1490 10413 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%R-HSA-2022090.5 Assembly of collagen fibrils and other multimeric structures 649 7837 1297 7093 7092 1284 50509 1282 1286 1281 1285 256076 5118 1280 255631 131873 1296 1295 1294 1293 1292 1291 1290 1302 1301 1289 1300 3914 1287 85301 3918 1306 3909 4318 1520 1514 1515 9313 977 5339 4314 3691 1278 1277 80781 84171 4322 4015 3655 4016 4017 4316 1508 84695 1299 1298 DEFECTIVE ABCD1 CAUSES ALD%REACTOME%R-HSA-5684045.4 Defective ABCD1 causes ALD 215 AZATHIOPRINE ADME%REACTOME DATABASE ID RELEASE 95%9748787 Azathioprine ADME 3615 3614 2987 2938 7172 3177 4831 9153 7498 10451 10257 7410 3251 5879 64078 55270 2030 2939 10057 7409 4830 8833 2944 EGR2 AND SOX10-MEDIATED INITIATION OF SCHWANN CELL MYELINATION%REACTOME%R-HSA-9619665.3 EGR2 and SOX10-mediated initiation of Schwann cell myelination 3908 5453 3912 84059 4359 5454 57716 4155 7003 7402 57211 3156 5376 4664 4665 25937 1959 4099 10413 1605 6597 1595 6721 1821 3066 6663 3915 79966 INHIBITION OF MEMBRANE REPAIR%REACTOME%R-HSA-9635644.5 Inhibition of membrane repair 9146 SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME DATABASE ID RELEASE 95%3232142 SUMOylation of ubiquitinylation proteins 23636 9631 7175 51588 9972 11097 23279 8086 23511 53371 8480 79023 79902 10762 5371 5903 7341 8554 7329 348995 9883 6396 5987 129401 9688 57122 23225 7428 4927 23165 55746 8021 4193 55706 POTASSIUM TRANSPORT CHANNELS%REACTOME%R-HSA-1296067.3 Potassium transport channels 3766 3758 3773 OLFACTORY SIGNALING PATHWAY%REACTOME%R-HSA-381753.8 Olfactory Signaling Pathway 81327 81442 132112 2774 393046 8390 109 8392 122742 26494 401427 26493 26496 401667 401666 282775 122740 401665 26497 81470 81472 282770 341276 122748 127074 341152 256144 1262 127077 1260 283617 120796 81469 119694 119695 120793 282763 81466 81341 343563 119692 387748 344892 79290 79296 135924 79295 26595 26476 284532 125958 442191 26246 442194 26248 442197 81127 26245 284521 135941 26339 26338 135946 26219 135948 26692 402317 26693 26333 26696 26212 81399 26211 81392 388761 343406 26341 8861 51764 2782 9355 56656 120065 121275 120066 283365 390883 390882 390649 124538 390648 283111 4991 4992 4993 442184 442185 442186 79310 79317 284433 341799 219954 219952 121130 79541 79544 121364 125963 125962 4994 79549 4995 283694 121129 219965 130075 219960 390431 390433 442361 390436 390437 390439 341418 79334 341416 79339 219959 219958 219957 219956 283162 138804 65055 138805 283160 138802 138803 390441 390442 390321 390201 390323 390445 390326 390327 144124 254973 144125 79324 283159 219968 127608 219986 219865 219983 219982 390892 219981 57101 401994 401993 401992 285659 81309 79473 81797 390538 7932 219858 219875 219874 219873 219870 390429 79346 79345 26188 81300 26189 219869 347168 26716 286365 283093 283092 347169 138799 390113 134083 391211 392309 150681 338674 338675 340980 283189 219417 219438 219437 219436 26707 219432 219431 338662 126541 403282 403284 127623 254879 283297 255725 219429 219428 284383 126370 390271 219447 390151 391121 390152 441308 390154 390275 441669 390155 390157 390036 390037 390038 441670 158131 138882 138883 138881 23538 390162 219453 390167 390168 347468 219469 1879 219464 338751 391107 391109 338755 254786 254783 10798 390260 390261 219479 390142 219477 162998 390264 391112 390144 390265 391114 219473 390148 79501 286362 390072 390195 390075 390197 390077 219487 390199 392376 390078 390079 219484 219482 392138 127385 143502 119764 119765 143503 81050 390081 390082 390083 390084 26687 119749 402135 26689 219493 81168 81285 392391 81282 392390 504190 390174 390054 26533 256892 390058 26532 390059 26534 26658 26539 26538 26659 26531 343173 390181 390061 343172 343171 343170 390063 441639 390064 389090 390066 390067 26664 343169 390190 81061 390191 403274 127062 403277 403278 127069 127068 127066 403273 127064 120787 119687 81099 119682 26529 441933 127059 26648 120775 120776 119678 119679 390093 392392 403253 441608 403257 391189 26735 128371 26737 8590 128372 391190 196335 346525 391192 391191 391194 391196 403244 391195 128366 128367 128368 128360 119774 119772 26740 403239 346517 79490 81328 120586 256148 81696 81697 8387 8388 8386 8383 81318 79482 81448 REPLACEMENT OF PROTAMINES BY NUCLEOSOMES IN THE MALE PRONUCLEUS%REACTOME DATABASE ID RELEASE 95%9821993 Replacement of protamines by nucleosomes in the male pronucleus 5619 8370 54145 8341 8342 8347 8348 8345 7290 132243 8340 10361 255626 124512 3021 6732 8970 3018 3017 85236 3014 128312 5620 8349 GENE AND PROTEIN EXPRESSION BY JAK-STAT SIGNALING AFTER INTERLEUKIN-12 STIMULATION%REACTOME DATABASE ID RELEASE 95%8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 3936 654483 3313 5478 6647 5898 6888 4001 5908 4282 5055 1072 27250 302 1265 3586 5721 4478 6950 2939 5306 759 829 998 6627 3458 3181 6175 9987 9049 6648 6775 9446 3185 4507 5062 375 LATE ENDOSOMAL MICROAUTOPHAGY%REACTOME DATABASE ID RELEASE 95%9615710 Late endosomal microautophagy 91782 8100 10013 92421 55048 89853 137492 51271 51160 155382 93343 7251 79720 10226 27243 5116 1080 128866 123 29082 25978 7311 7314 6233 3043 6035 3312 7316 1068 79643 11315 51652 200894 PI3K AKT SIGNALING IN CANCER%REACTOME DATABASE ID RELEASE 95%2219528 PI3K AKT Signaling in Cancer 940 2931 930 118788 941 942 5880 6199 50852 253260 1950 1956 2099 1027 5156 5781 27006 8503 2549 5159 8660 9542 10718 145957 3815 10818 208 8817 26281 7409 1839 391 9965 1147 2254 2252 2251 4233 572 8074 2249 2248 2247 1026 2246 2323 2322 152831 5879 8823 5295 5296 2264 2308 5290 5291 5170 2255 55615 9846 3667 64223 3084 84335 2475 7249 2932 146850 5294 6714 2100 23533 4193 2064 6801 207 5728 374 3164 2534 3932 3082 5293 4915 4909 4303 627 7039 685 5155 255324 2069 10000 2309 842 79109 4916 4908 TRANSLATION INITIATION COMPLEX FORMATION%REACTOME%R-HSA-72649.4 Translation initiation complex formation 8894 8662 1965 8663 8661 8666 1975 8667 8664 1968 8665 27335 3646 51386 7458 8668 1977 8669 10480 1964 6233 1981 6230 6232 6210 6231 6234 6235 6191 2197 6193 6192 6194 51065 140032 6205 6227 6204 6207 6229 6206 1974 6228 1973 6209 6208 6188 6187 6223 6201 6189 26986 6222 6203 6224 6202 6218 6217 3921 NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME%R-HSA-5676590.3 NIK-->noncanonical NF-kB signaling 5706 5707 5708 5709 5700 5701 5702 5704 5705 5682 5683 23291 5684 5685 5686 5717 5718 5719 9020 11047 5713 5714 5690 5971 5691 9039 5692 5693 5694 7311 7979 5695 7314 9040 9861 8454 6233 5687 5688 5689 7316 6500 4791 10213 1147 8945 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME DATABASE ID RELEASE 95%196791 Vitamin D (calciferol) metabolism 5641 6613 51588 4036 7329 7421 2638 1594 8029 1591 26119 120227 MINUS-STRAND DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%164516 Minus-strand DNA synthesis 5478 HOMOLOGY DIRECTED REPAIR%REACTOME%R-HSA-5693538.4 Homology Directed Repair 51588 29086 51720 25 10721 51548 142 10714 5424 5425 57804 5981 2072 63967 56655 7515 7334 7336 8970 5426 5427 128312 79184 3980 51426 10038 8370 2067 54107 8341 8342 8347 8290 8348 6047 8345 8340 255626 3018 3017 85236 3014 8349 54145 348654 146956 197342 84464 9656 23514 80198 1017 79008 2237 8924 7329 6233 6613 7316 165918 7468 7158 7486 5982 5883 5884 5983 116028 3364 472 5429 10635 54962 9025 672 151987 675 5893 84126 5531 1111 8914 83990 144715 63979 83695 51750 5810 7516 10111 5932 7517 7311 7979 4361 5111 7314 7156 5890 9156 5892 55732 84142 4683 11073 9577 580 10524 641 1763 545 6117 5984 890 5985 6119 8900 79728 5888 6118 80010 5889 GALACTOSE CATABOLISM%REACTOME%R-HSA-70370.7 Galactose catabolism 231 2592 2584 2582 5236 130589 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 95%113507 E2F-enabled inhibition of pre-replication complex formation 84515 5000 5001 23595 23594 891 4998 983 4999 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 95%186797 Signaling by PDGF 6696 5045 5340 1399 5295 6772 5296 1297 5290 80310 5291 1284 1282 1286 1285 5327 256076 2886 131873 7059 1398 7060 1293 1292 1291 6714 1287 6777 4690 7057 5335 6776 5782 9564 5156 7058 5921 5781 4893 5159 2889 6778 5155 8440 6774 6654 1299 1298 3265 ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME DATABASE ID RELEASE 95%1369062 ABC transporters in lipid homeostasis 20 5825 8504 10350 64137 335 23461 21 23460 5824 225 9619 64241 64240 10349 215 26154 10347 ACTIVATION OF GABAB RECEPTORS%REACTOME%R-HSA-991365.6 Activation of GABAB receptors 113 114 3772 115 2774 107 108 55970 109 196883 3762 3763 3765 3766 3768 54331 59345 2793 2792 3773 346562 2791 2790 2788 2782 2787 2786 2785 2784 2783 51764 10681 9568 2771 2770 94235 3760 3761 2550 3759 111 112 2773 CRISTAE FORMATION%REACTOME%R-HSA-8949613.3 Cristae formation 10989 516 517 10632 125988 3313 10651 55735 84303 518 4580 8834 84833 521 522 139322 54927 27109 498 9551 539 10476 9556 25813 509 506 4508 4509 513 514 440574 515 79135 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%R-HSA-5099900.2 WNT5A-dependent internalization of FZD4 163 5579 1856 8322 1213 1211 1175 1173 7474 5578 409 160 1212 5582 161 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME%R-HSA-446203.8 Asparagine N-linked glycosylation 6708 91445 6048 6710 6712 375056 10956 9334 10959 9331 22872 8729 9871 378 7369 9632 1294 57731 10427 966 287 288 1604 51332 2801 2683 6709 811 9486 10113 9554 9570 55860 11015 51164 55738 830 10671 1639 93661 84061 11282 7841 84516 2923 55741 1650 11320 4247 100128731 4249 6185 7991 4124 51399 4245 6184 25834 23193 58505 201595 2530 821 11253 5589 746 1603 3703 6233 7316 5537 79090 22870 11070 9117 11196 254263 375 81562 1453 27095 149111 9919 89866 7109 4253 6399 79694 5700 23243 2348 10175 126003 25956 55014 10802 10652 51693 3998 122553 10540 1075 10484 64377 2525 83696 90411 10282 26984 55291 79748 128637 10960 829 377 7311 10121 7314 11258 5887 79644 10342 1081 2804 6811 832 6396 26286 6711 2720 1522 8655 84364 58485 7415 2517 1315 3972 3630 26958 8774 8775 51143 23256 10945 1781 63908 51014 1780 57511 1778 9761 23423 64772 80267 84447 372 10299 84342 55768 9695 91949 10206 4121 1783 56886 267 4905 4122 381 51035 7844 55757 11236 51272 57134 9527 140735 140838 22796 29906 207063 6675 9382 2890 124872 56052 81849 440138 79053 84920 51046 5973 10972 51005 10610 6483 22845 6482 6484 25839 55808 9276 6487 6489 4248 64841 5476 10020 3098 11316 79087 83548 256281 6480 144245 256435 10905 10825 55577 286 2673 10466 8813 27090 30815 22818 9945 85365 8703 197258 8704 8818 8702 1314 7264 29929 54732 4351 10195 51226 4597 338596 8790 29926 29925 374 55343 22820 29880 1798 79796 11014 10559 79139 84620 2762 5265 81876 91869 5861 51009 8869 5238 116150 432 6400 433 5372 2153 5373 55907 8128 57171 26503 282969 199857 54187 64689 80896 7039 54344 79868 9526 79947 7903 4758 51128 8615 10402 129807 4759 2157 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 95%141405 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components 8881 64682 25906 11065 8697 7324 10393 29945 27338 119504 29882 246184 996 51434 51433 4085 9184 991 51529 7321 701 RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%111457 Release of apoptotic factors from the mitochondria 578 581 1687 54205 56616 79792 DRUG RESISTANCE IN ERBB2 TMD JMD MUTANTS%REACTOME DATABASE ID RELEASE 95%9665737 Drug resistance in ERBB2 TMD JMD mutants 11140 3320 2064 55914 FIBRONECTIN MATRIX FORMATION%REACTOME%R-HSA-1566977.5 Fibronectin matrix formation 634 3678 1088 3688 4680 2335 HS-GAG DEGRADATION%REACTOME DATABASE ID RELEASE 95%2024096 HS-GAG degradation 6382 2239 2719 2817 375790 10855 60495 3339 6448 3425 4669 6383 221914 1514 3423 9672 10082 6385 2262 UBIQUITIN-MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME%R-HSA-69601.6 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 993 9861 6233 9978 2932 7316 1452 11200 10213 8945 79858 1454 5706 5707 5708 5709 5700 1263 5701 5702 5704 5705 5682 23291 5683 5684 5685 5686 5717 5718 5719 1432 11047 1111 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 8454 5687 5688 5600 5689 6500 EPIGENETIC REGULATION OF GENE EXPRESSION BY MLL3 AND MLL4 COMPLEXES%REACTOME%R-HSA-9818564.2 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 84661 11091 5929 10025 9968 9969 892 10001 9070 25 29079 5469 63924 58508 5925 8970 8331 8337 128312 9862 8334 8335 2033 8370 55766 8968 8341 8342 57678 8347 8348 94239 8345 3013 8340 8338 255626 2180 6256 3021 653604 3018 3017 85236 3014 8349 90390 60481 474382 84649 6319 1050 54145 2167 11343 6907 3991 51003 8648 79718 23175 84246 9612 10891 8841 9611 729359 123 23054 9443 22976 2874 9442 5166 5346 9440 8202 133522 948 9439 84962 79447 8085 2494 9477 22822 1020 57104 8800 10499 7069 1387 9370 1024 79611 23411 7403 51129 10555 4023 9282 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME DATABASE ID RELEASE 95%174178 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 9212 9861 6233 6790 7316 10213 51529 7321 5706 8881 64682 5707 25906 5708 11065 8697 5709 7324 10393 29945 27338 119504 5700 5701 29882 5702 246184 996 5704 51343 51434 6502 5705 51433 5347 5682 5683 5684 5685 5686 5717 5718 5925 5719 991 11047 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 5687 5688 5689 9232 ACTIVATION OF PUMA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%139915 Activation of PUMA and translocation to mitochondria 23368 7161 7029 7027 8626 1869 27113 7159 7157 DISEASES OF CARBOHYDRATE METABOLISM%REACTOME%R-HSA-5663084.5 Diseases of carbohydrate metabolism 2548 6888 3938 6476 2799 229 6448 138050 378884 4669 8908 7957 2992 2998 2632 22934 5507 7311 2588 7314 2990 92579 6233 3373 3795 3425 7316 411 2720 3423 51181 2542 2538 2997 SYNTHESIS OF CL%REACTOME%R-HSA-1483076.4 Synthesis of CL 54675 DEVELOPMENTAL CELL LINEAGES OF THE EXOCRINE PANCREAS%REACTOME DATABASE ID RELEASE 95%9820448 Developmental Cell Lineages of the Exocrine Pancreas 2252 3918 2255 284217 3908 1950 3909 7448 3910 3911 2249 3912 2247 3913 3914 3915 2335 10319 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-HSA-194313.3 VEGF ligand-receptor interactions 7422 2324 3791 7424 7423 2277 2321 5228 HIV INFECTION%REACTOME DATABASE ID RELEASE 95%162906 HIV Infection 163 1175 1173 905 920 79643 51652 8945 91782 92421 4869 3837 27243 128866 2961 2960 10015 2959 2958 2957 29082 25978 4836 6872 6874 6873 5879 6908 2237 6880 6883 6882 6884 6875 6878 8812 6877 6879 5901 9861 6233 9978 7316 6921 6923 7514 10213 5440 8732 5441 4331 8021 8731 375 1022 5062 5706 2071 5707 2966 5708 6829 2965 5709 2963 5478 2962 2068 5434 5435 5700 5436 5701 5437 5438 5702 5439 2968 2967 404672 5704 5705 5430 5431 5682 138474 5432 5683 5433 5684 5685 902 5686 5717 5718 5719 11047 5713 5714 5690 5691 5692 5693 5694 8065 7311 5695 7314 5687 5688 5689 23327 5045 55048 89853 1104 51534 9525 137492 27183 6881 9844 10053 51271 8907 51160 155382 8905 130340 93343 7251 1174 162 79720 55690 5902 164 51510 3105 940 567 926 129685 2547 7520 3981 7518 348995 9883 6396 129401 9688 291 292 57122 293 23225 3836 4927 3159 23165 11168 9397 55746 55706 23636 9631 7175 9972 11097 23279 8086 23511 53371 8480 51616 79023 79902 10762 8815 5903 3978 54457 51606 83860 5905 1794 7852 1234 8148 8178 22916 25920 4686 51224 6924 7936 6827 6749 9150 6917 1025 51497 2534 7469 11198 3055 3932 904 7979 6500 160 161 SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA%REACTOME DATABASE ID RELEASE 95%9662361 Sensory processing of sound by outer hair cells of the cochlea 7430 10083 64787 222662 83715 389207 2059 5756 5962 140469 2036 4627 8573 3778 3779 6711 6709 55584 3781 57053 2934 4478 4641 129446 25861 161497 124590 51168 11344 64072 9132 4647 53904 494513 9750 259236 65217 23136 339768 117532 117531 25794 283310 340990 643226 286262 375611 4354 10518 5357 53405 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 95%427652 Sodium-coupled phosphate cotransporters 142680 6569 10568 6575 6574 6568 HCMV LATE EVENTS%REACTOME%R-HSA-9610379.4 HCMV Late Events 55048 89853 137492 27183 51271 51160 155382 93343 7251 79720 221613 84313 51028 11267 5119 348995 9883 6396 129401 92815 9688 8969 79643 57122 51652 23225 440689 4927 23165 8021 55746 55706 23636 9631 91782 7175 9972 11097 23279 8086 92421 23511 53371 8480 3190 79023 79902 10762 5903 8970 27243 8331 128866 8337 128312 8334 8335 29082 8370 25978 1052 8968 317772 8341 8342 8347 85235 8348 8345 3013 8340 8338 255626 653604 3018 3017 85236 8349 COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 95%6807878 COPI-mediated anterograde transport 6708 84516 10945 1781 63908 1780 51014 6710 57511 6712 1778 23423 372 84342 91949 1783 4905 381 10959 51272 8729 9527 140735 2804 22796 9382 6811 378 832 26286 10972 57731 6711 25839 966 9276 11070 287 288 1604 51332 375 11316 83548 2801 286 6709 10466 2348 22818 10652 1314 10540 8655 54732 84364 51226 10282 829 22820 377 11014 1315 81876 5861 3630 10121 9570 11258 64689 26958 8774 8775 8615 51143 55860 51164 11015 55738 830 10671 1639 93661 PI-3K CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 95%5654695 PI-3K cascade:FGFR2 2252 27006 2255 2251 8074 2549 2249 2248 2247 10818 2246 8823 8817 5295 26281 5781 5290 2254 GLYCOSPHINGOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%9840309 Glycosphingolipid biosynthesis 84002 8869 53947 9514 29906 30815 81849 2524 2523 6483 8705 8706 9334 9331 64781 6487 7357 7368 2583 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-HSA-156827.5 L13a-mediated translational silencing of Ceruloplasmin expression 6152 6155 6154 6157 9349 6156 6159 6158 23521 51121 11224 6164 200916 6166 6122 6165 6124 6168 6123 6167 6169 6125 116832 25873 6160 6161 140801 4736 6130 6133 9045 6230 6232 6132 6210 6176 6231 6135 6234 6134 6235 6137 6191 6136 2197 6193 6171 6192 6170 6194 6173 6128 51065 6129 140032 6142 6205 6227 6141 6144 6204 6143 6207 6229 6146 6147 6206 1974 6228 6181 1973 6139 6138 6209 6208 6188 6187 6223 6201 6189 6222 6203 6224 6202 6218 6217 3921 8894 8662 1965 8663 8661 8666 1975 8667 8664 1968 8665 27335 3646 51386 7458 8668 1977 8669 10480 1964 6233 6175 1981 7311 26986 INTERLEUKIN-38 SIGNALING%REACTOME DATABASE ID RELEASE 95%9007892 Interleukin-38 signaling 8808 84639 11141 5599 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 95%71064 Lysine catabolism 85007 123688 51166 55526 89874 10157 1743 2639 1738 1428 501 51268 TGFBR3 REGULATES TGF-BETA SIGNALING%REACTOME%R-HSA-9839389.1 TGFBR3 regulates TGF-beta signaling 7049 7046 10755 7048 7040 408 409 7042 SIGNALING BY FGFR IN DISEASE%REACTOME DATABASE ID RELEASE 95%1226099 Signaling by FGFR in disease 2252 2251 8074 2249 2248 399687 2247 2246 8823 8805 5295 6772 2264 5290 1523 2255 9846 11052 9208 7750 26127 5440 5441 9530 2261 6777 5335 2963 2962 6776 5434 5435 5436 5437 5438 5439 2263 22916 5430 4686 5431 5432 11116 5433 4893 27006 2549 613 10818 11160 8817 6774 26281 2260 6654 2254 3265 SIGNALING BY NTRKS%REACTOME DATABASE ID RELEASE 95%166520 Signaling by NTRKs 163 5045 5046 5125 4803 5906 6446 1759 7166 6236 2152 3399 4066 8941 1175 8061 1173 3727 1785 581 7425 3400 2354 1399 10221 4664 4665 1959 1958 3398 3397 23237 1961 116 1960 117 429 5899 25759 6014 6016 135 6300 5603 10126 53358 4914 5900 57498 26052 1398 1108 5335 5781 4893 5978 2033 2549 8660 5594 5595 1386 10818 6774 5604 5598 387 5605 51231 1849 1848 6654 1846 1845 3265 6456 6457 5879 466 4208 7074 5295 7867 5296 6464 5519 5802 5290 5291 6722 3667 5515 5516 5518 1795 9261 2904 5528 6714 5800 6938 673 4209 5898 5607 1020 7529 10817 25920 8851 1432 2889 6197 6196 4915 4909 9252 6195 627 4205 2353 5600 1213 1211 3726 2002 160 4916 161 4908 DEFECTIVE MPDU1 CAUSES CDG-1F%REACTOME DATABASE ID RELEASE 95%4687000 Defective MPDU1 causes CDG-1f 9526 DEFECTIVE SLC11A2 CAUSES HYPOCHROMIC MICROCYTIC ANEMIA, WITH IRON OVERLOAD 1 (AHMIO1)%REACTOME DATABASE ID RELEASE 95%5619048 Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) 4891 DEFECTIVE ABCC2 CAUSES DJS%REACTOME DATABASE ID RELEASE 95%5679001 Defective ABCC2 causes DJS 1244 REGULATION OF KIT SIGNALING%REACTOME DATABASE ID RELEASE 95%1433559 Regulation of KIT signaling 5777 8651 867 3815 10019 9306 4067 5578 7525 2534 6654 10603 3932 SIGNALING BY NTRK3 (TRKC)%REACTOME DATABASE ID RELEASE 95%9034015 Signaling by NTRK3 (TRKC) 3667 5335 25920 581 5295 5800 6714 6654 5802 4893 5290 4916 3265 4908 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%425381 Bicarbonate transporters 9497 57835 57282 83697 6521 6508 6522 23382 9498 8671 METHYLATION OF MESEH FOR EXCRETION%REACTOME DATABASE ID RELEASE 95%2408552 Methylation of MeSeH for excretion 11185 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE%REACTOME%R-HSA-110330.6 Recognition and association of DNA glycosylase with site containing an affected purine 474382 4350 54145 8970 8331 8337 128312 8334 8335 4968 8370 55766 8341 8342 8347 8290 8348 55247 94239 8345 26277 3013 25913 8340 7013 65057 7014 8338 255626 54386 3018 3017 85236 3014 8349 DEFECTIVE CSF2RB CAUSES SMDP5%REACTOME DATABASE ID RELEASE 95%5688849 Defective CSF2RB causes SMDP5 653509 729238 6441 6440 6439 1439 1438 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 95%111465 Apoptotic cleavage of cellular proteins 9414 2339 329 6709 7431 4001 1499 841 1828 100506658 1832 63967 6093 1830 2934 1829 22985 839 10134 6304 5317 999 660 7082 2620 5580 5339 4137 118 51765 28988 324 5747 840 5588 836 8428 TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME DATABASE ID RELEASE 95%6803211 TP53 Regulates Transcription of Death Receptors and Ligands 8797 124446 23368 7161 355 8626 7159 8794 8795 3486 8793 7157 DEFECTIVE SLC17A8 CAUSES AUTOSOMAL DOMINANT DEAFNESS 25 (DFNA25)%REACTOME%R-HSA-5619076.4 Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) 246213 METABOLISM OF VITAMIN K%REACTOME%R-HSA-6806664.5 Metabolism of vitamin K 154807 79001 29914 PDH COMPLEX SYNTHESIZES ACETYL-COA FROM PYR%REACTOME DATABASE ID RELEASE 95%9861559 PDH complex synthesizes acetyl-CoA from PYR 5162 1737 1738 8050 5160 5161 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 95%982772 Growth hormone receptor signaling 1154 5777 3667 8651 2690 6776 8660 9021 2689 5594 5595 5618 8835 1442 2688 4067 6868 6774 6772 5770 6777 5617 3717 AMPK-INDUCED ERAD AND LYSOSOME MEDIATED DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 95%9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 91445 6048 91319 10956 5562 5563 5564 5565 51422 5571 9861 6233 53632 7316 10213 29126 5706 5707 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 7415 5717 5718 5719 27248 11047 79139 5713 5714 51009 5690 5691 5692 6400 5693 5694 7311 7979 5695 7314 11160 5687 5688 5689 10613 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME%R-HSA-400042.7 Adrenaline,noradrenaline inhibits insulin secretion 783 55970 54331 775 59345 2793 2792 2791 2790 2788 2782 2787 2786 784 2785 2784 2783 51764 10681 150 152 2771 2770 94235 776 111 112 9254 HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME%R-HSA-450520.4 HuR (ELAVL1) binds and stabilizes mRNA 6418 7514 5578 8125 5580 1994 8741 8021 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN LYSOSOME BIOGENESIS AND AUTOPHAGY%REACTOME%R-HSA-9857377.3 Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy 526 527 427 9114 528 51606 529 8992 533 9550 523 LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS%REACTOME%R-HSA-8876384.4 Listeria monocytogenes entry into host cells 6456 4233 6455 2060 999 867 6457 7311 7314 9146 6233 79872 10254 1499 8027 7316 1500 6714 30011 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 95%372790 Signaling by GPCR 553 113 554 114 115 50840 2774 107 108 109 196883 5739 5138 3710 6753 5153 116 117 5321 27202 135 1395 5136 719 7349 2847 2778 10846 3708 3709 50940 4852 727 728 1604 3549 5533 7204 55160 23365 9181 1392 128272 57580 26230 121512 1894 10451 7410 84904 100271715 26084 23370 25791 89846 9826 54848 5598 9828 7409 23229 22899 50649 8997 6453 7984 29 8874 64857 57449 389337 445328 2245 23263 50650 221472 9639 10672 10276 55701 9459 9138 4168 27237 7074 6655 136 11214 2781 5924 5729 11251 5731 5732 5733 5734 5737 6915 7252 7473 7479 2357 7478 695 146850 5294 3579 23533 3577 976 154 2793 2792 2791 5581 2790 5582 156 5579 3838 5137 2788 10645 10768 2787 26960 2786 10636 84254 10888 2785 26086 84152 6197 2784 85397 6196 2783 8601 126006 51764 6195 8622 5141 5143 5144 5139 5151 6001 6002 5150 157 9560 11245 9630 11250 5588 94235 285601 26166 6000 2838 2843 2848 8787 29899 27115 2854 8786 2850 2870 2864 63940 2695 55970 9628 183 54331 2767 53831 59345 408 409 2769 2782 2776 10681 2919 2692 2691 9340 2740 7433 6344 7432 6343 7434 2696 5196 5140 4893 5364 8503 998 3972 84658 5594 5595 208 387 388 6654 389 3265 6351 6352 58191 6354 6357 6356 6348 6347 6349 2826 10850 6361 9034 6364 6363 6366 6367 1230 5583 6360 2833 9162 643 8527 10663 26090 8525 6373 8526 6372 5295 57406 3688 6374 5296 221955 6376 160851 6370 1238 1609 5519 747 2921 5290 1608 57007 2920 1607 1237 5170 1606 1236 139189 1233 3576 1232 56477 4283 5515 6387 6346 5516 10803 808 5518 51554 10563 3627 815 7852 1234 5528 5020 6714 4295 7200 2768 816 5021 7201 431704 56413 817 818 5031 5032 6003 1909 1908 6004 94233 2798 2797 2796 1907 5028 1906 84432 5029 6375 1241 2693 1910 84109 10874 29933 222545 10887 5724 10886 257313 64407 387129 2911 2358 846 2915 4985 7484 8111 8477 2922 5996 2147 5997 5998 5999 2925 54361 6846 10161 185 623 351 5030 624 53829 2488 4314 140 10287 64805 134 56923 9934 8490 2151 2150 57105 2149 2829 2828 353299 885 886 887 2837 347148 9002 338557 3814 10911 2840 2846 5332 594857 64106 301 129521 128674 2867 3827 2865 2863 5566 2862 5567 60675 4922 5568 4923 10800 2869 10235 8620 10125 680 27334 84634 3060 5367 23620 3062 3061 10316 4828 4829 2642 2641 26575 5473 2520 84539 729230 7222 7225 163404 8698 57121 9170 9890 57113 23566 64748 9294 54886 79948 1903 1902 1901 53637 1235 1129 1128 1133 1132 1131 5499 7483 89780 5573 5575 5576 5577 5613 7481 5534 7976 7855 8322 5330 5331 5530 9287 3363 8323 5532 3362 150 2780 3361 23236 151 2535 3360 152 59340 153 155 3358 165140 3357 3356 1839 3355 1816 83551 1815 1814 1813 1812 134864 319100 134860 9038 3354 3352 3274 3351 3350 146 147 148 3269 11255 4935 5956 5580 4986 4988 5578 207 1020 5726 5058 6750 133 796 797 799 718 259289 79924 3375 10266 259287 10268 259286 10267 259285 10203 6608 9475 259293 5727 259292 259290 6093 259296 259295 5443 2652 1081 115557 6010 54429 2779 1956 4158 80835 80834 7480 611 221391 5995 10692 23596 3640 51083 90226 1240 56670 338398 3678 170589 4987 3792 6469 27198 50846 27199 5741 2550 80326 6288 2587 4886 4887 4889 122042 1394 1393 2359 1269 1268 5744 5745 5746 2492 11343 4543 4544 259294 2015 353164 6751 5540 6752 5539 116512 338442 6755 10022 6754 8811 339403 346562 51384 151306 8843 5697 8321 256933 8325 7504 7471 11211 51289 4142 8862 51052 4157 114131 9718 4161 8643 4160 5368 4159 30817 117579 113091 5173 7472 7475 7477 9568 8326 2771 7476 2770 6019 7482 1524 7253 2918 2917 2916 2913 2912 2773 8484 186 187 50835 2834 2832 2831 122876 1880 283869 2841 57486 2914 2853 551 2852 2859 50865 1889 2861 9283 3973 9290 59350 1325 2532 6870 6863 6865 6866 6869 814 83756 50831 50833 50832 10000 50834 5179 50837 7474 50836 8324 50839 50838 5660 111 552 112 SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS%REACTOME%R-HSA-1839117.4 Signaling by cytosolic FGFR1 fusion mutants 9846 11052 6776 613 9208 399687 7750 26127 11116 8805 6774 5295 6772 5290 1523 6777 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME DATABASE ID RELEASE 95%2871809 FCERI mediated Ca+2 mobilization 5335 9402 4773 4775 3937 3710 3702 6850 4772 7294 5534 10768 808 5530 10451 5532 7410 4067 695 7006 3708 3709 7409 6654 5336 PROTEIN LIPOYLATION%REACTOME DATABASE ID RELEASE 95%9857492 Protein lipoylation 1737 1743 1629 4706 11019 387787 27247 2653 2230 51601 TRANSLESION SYNTHESIS BY POLK%REACTOME%R-HSA-5655862.2 Translesion synthesis by POLK 7311 5111 7314 5980 6233 10459 51455 5981 5982 6117 5984 7316 5983 5985 6119 6118 51426 RETINOID CYCLE DISEASE EVENTS%REACTOME%R-HSA-2453864.5 Retinoid cycle disease events 24 611 64220 7276 9227 5950 5959 222236 6017 145226 5956 5947 2652 NUCLEAR ENVELOPE (NE) REASSEMBLY%REACTOME DATABASE ID RELEASE 95%2995410 Nuclear Envelope (NE) Reassembly 10383 200014 260334 10382 112714 4001 7846 1104 84790 27183 84617 5905 347733 7277 7278 7341 79861 7329 5515 81027 5901 5518 348995 9883 6396 129401 9688 79643 57122 51652 23165 55746 55706 23636 9631 91782 23279 92421 23511 53371 79023 3842 891 79902 8815 983 3837 25909 113457 27243 5520 7280 128866 29082 2010 25978 22933 3930 10376 6683 9133 80086 23141 347688 7443 9798 51807 23592 221496 10381 LXRS REGULATE GENE EXPRESSION LINKED TO TRIGLYCERIDE LIPOLYSIS IN ADIPOSE%REACTOME DATABASE ID RELEASE 95%9031528 LXRs regulate gene expression linked to triglyceride lipolysis in adipose 7376 6256 5346 10062 6257 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%R-HSA-2691232.3 Constitutive Signaling by NOTCH1 HD Domain Mutants 28514 182 7311 7314 6233 9148 54492 4851 7316 142678 6868 3714 57534 102 54567 PEROXISOMAL PROTEIN IMPORT%REACTOME%R-HSA-9033241.5 Peroxisomal protein import 8528 3416 8540 5828 54363 8310 4843 2053 3417 51268 30 8309 8443 1891 3155 122970 7323 6233 7322 4358 10005 5189 1384 7316 54677 7321 51 5195 5190 3295 5191 5192 5193 5194 10901 51179 219743 373156 570 55825 83752 7311 847 6342 7314 55670 26063 10965 11001 196743 189 1962 54469 26061 5264 23600 283927 8239 1610 390916 TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME%R-HSA-6804115.2 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 4848 4849 9125 7832 9337 57472 4869 1263 246175 5325 995 10769 55835 25904 85456 28984 23019 4850 29883 7157 55571 TOXICITY OF BOTULINUM TOXIN TYPE G (BOTG)%REACTOME%R-HSA-5250989.4 Toxicity of botulinum toxin type G (botG) 6844 6857 6843 ASSEMBLY OF VIRAL COMPONENTS AT THE BUDDING SITE%REACTOME DATABASE ID RELEASE 95%168316 Assembly of Viral Components at the Budding Site 821 811 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 95%9020558 Interleukin-2 signaling 3716 3561 3560 6776 3559 3558 6464 3718 6850 2185 3932 6777 BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME%R-HSA-9018683.3 Biosynthesis of DPA-derived SPMs 246 5743 239 240 PRC2 METHYLATES HISTONES AND DNA%REACTOME DATABASE ID RELEASE 95%212300 PRC2 methylates histones and DNA 474382 2146 54145 22823 5928 2145 8970 8331 8337 128312 8334 121536 8335 8370 55766 26147 8968 5931 8341 340602 8342 8347 8348 23512 94239 8345 3013 1789 8340 1788 1786 3720 8338 255626 3021 8726 653604 3018 5252 3017 85236 100170841 3014 8349 SUNITINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674401.2 Sunitinib-resistant PDGFR mutants 5156 TALDO1 DEFICIENCY: FAILED CONVERSION OF FRU(6)P, E4P TO SH7P, GA3P%REACTOME%R-HSA-6791462.4 TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P 6888 SIGNALING BY RHO GTPASES%REACTOME DATABASE ID RELEASE 95%194315 Signaling by Rho GTPases 57498 2319 9414 708 6709 9146 1828 1832 10134 10971 7204 55075 55160 23365 9181 128272 57580 10211 26230 121512 1894 10451 7410 84904 26084 23370 25791 89846 9826 9828 7409 23229 22899 50649 8997 6453 7984 29 8874 64857 57449 2245 23263 5300 50650 221472 995 9639 10672 10276 55701 5879 9459 9138 4168 27237 7074 6655 11214 5924 4221 9738 367 695 1072 908 5579 7532 7531 7533 10376 8239 60 10254 8027 65124 55200 399693 1080 253959 4722 23616 56667 57636 57630 55219 5825 64283 1362 22852 55227 26092 91544 1124 2697 10409 6811 91452 27289 348995 832 10970 6396 4649 10505 57679 6711 5880 57122 114885 79598 3336 284119 25 27145 4548 57579 57216 55746 253980 10963 4690 5783 55968 54514 4580 23279 55852 8086 4698 11113 10144 25963 79023 79834 79902 2185 23433 667 5903 79822 54908 9928 6232 6793 8655 25909 5585 5586 8379 9183 3163 1063 54438 1062 5338 7415 157285 91010 9184 9938 1060 23779 8502 1855 991 54443 151648 9824 5361 55166 752 5364 1058 7535 8503 79019 998 9855 9732 151246 25813 9735 224 1857 6472 1856 23332 11180 11060 57591 8776 79003 1152 5594 94240 55055 5595 29941 81565 85415 22919 30849 348235 11188 10818 84681 5048 23421 6242 8301 220134 11075 57082 1495 120 23380 57405 84317 51143 9748 23141 147841 4085 8440 64105 94134 9528 401541 10403 7126 387 390 81624 391 5289 388 26999 6654 389 23129 54820 399 80776 222584 701 51566 54821 171177 23256 378708 286205 9322 84144 1781 23122 55704 70 1780 23002 2802 65992 79172 5099 1778 81930 9217 55920 55831 51479 84643 114793 54509 55717 29984 3796 9462 5216 10810 5217 1730 9793 80005 91687 22800 57551 537 93663 79682 26049 9590 5905 57473 1783 5501 5295 7170 3688 5296 9231 7171 83540 123720 80152 2491 80115 5519 158747 332 5290 57120 55143 8153 699 5170 63916 6722 84986 11243 9497 51466 50618 71 157769 84612 3619 140735 114822 5515 57381 11004 3954 5516 445582 808 5518 58480 9212 2631 25936 29843 11130 2886 1795 64946 79980 1742 1794 10726 1793 1729 152273 5525 79180 5526 23074 55839 23197 5527 5528 5500 5529 6714 1445 10817 5347 4659 3932 182 1629 1213 6249 6279 4628 79784 4629 3984 3985 103910 4637 4627 6280 2316 23221 29766 55023 7919 5756 124540 3326 87 1499 55004 4638 999 5580 8773 7514 50508 5578 7444 6510 2909 9743 57584 7534 392 9341 394 5062 395 1536 10811 397 1535 10458 55843 10979 9815 7879 55845 4688 4689 7529 10298 10652 3998 9235 9710 81839 23092 55971 143872 347902 1829 4810 55619 85360 8936 1432 10424 10787 5881 27 10152 64411 124056 2010 23344 143098 2889 29127 4983 613 857 8987 3930 55789 51347 5600 26050 3071 4162 7112 7037 5058 10163 28964 80728 22865 23191 653361 23592 23075 116984 55114 27035 11135 4952 1969 10006 55914 4001 7431 9475 8452 6434 8654 10250 9886 27316 23013 9352 6093 3183 11329 56254 2873 79869 5930 10574 51138 9318 10576 4646 1627 4296 10928 115557 23048 26030 80243 54874 79658 64130 83478 7454 9754 7456 115703 2040 139818 201176 10788 57514 51133 26286 9901 64333 9644 116985 23268 147179 57480 117289 57522 3895 9912 50855 51306 8826 11140 343578 3320 9411 50619 221178 101059918 124997 58504 257106 1123 23526 5063 4650 153478 57144 644150 393 55240 396 398 1027 84364 5337 29062 148170 51291 5590 8970 3728 8331 144402 8976 8337 85440 128312 90627 8334 8476 56990 8335 81704 23348 89839 8370 57569 55766 23580 8968 10395 10435 92799 8341 10160 8342 9578 8347 25894 57572 8348 23513 94239 10602 8345 3013 128239 56924 8340 8338 255626 3021 653604 3018 3017 200894 85236 3014 8349 474382 54145 23028 4771 3798 3799 4660 2017 54763 10398 10109 10552 10093 10092 10095 10094 10097 2810 10096 64837 354 94274 89953 147700 3817 23081 3831 30851 9055 51517 10499 5747 ROS AND RNS PRODUCTION IN PHAGOCYTES%REACTOME%R-HSA-1222556.11 ROS and RNS production in phagocytes 127124 1536 23545 1535 51382 4688 84329 4689 533 534 535 4842 4843 10312 4353 50617 4846 9296 245972 245973 155066 9114 4025 51606 9550 523 525 526 527 528 5880 6556 529 8992 653361 90423 SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME DATABASE ID RELEASE 95%4615885 SUMOylation of DNA replication proteins 23636 9631 7175 51588 9972 11097 23279 8086 23511 53371 8480 79023 79902 10762 5903 5905 332 55143 7341 3619 7329 5111 10401 9212 6790 348995 9883 6612 6396 129401 6613 9688 57122 23225 4927 7153 7155 23165 7150 55746 8021 55706 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 95%114608 Platelet degranulation 51706 2 7076 7078 7873 7114 3671 66005 213 7040 3273 335 3827 1521 6414 139322 308 3700 6813 10487 3309 7123 5340 5341 5345 29106 83706 3959 54676 710 1893 259215 7277 5473 10184 78991 51571 967 9948 6694 5004 334 5919 55664 5874 7018 1191 3699 374354 7273 10447 5175 54863 5005 2316 81 5768 2335 1950 5196 3690 3674 7043 7042 27154 6678 5099 87 5216 5054 808 88 948 7422 7424 7423 2277 2244 2266 7057 7414 5478 6647 7450 2243 7094 226 1072 7044 3082 5265 2621 22915 10490 5267 29789 2153 3481 5627 350 94121 351 197 3479 51368 8407 10257 12 5155 5552 22927 2162 1 51097 23052 2157 9749 3920 928 135228 54495 5660 10916 6403 1675 813 RHOT1 GTPASE CYCLE%REACTOME%R-HSA-9013425.2 RHOT1 GTPase cycle 22906 5910 66008 80179 55288 ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-139910.5 Activation of BMF and translocation to mitochondria 140735 90427 5599 KERATAN SULFATE DEGRADATION%REACTOME%R-HSA-2022857.7 Keratan sulfate degradation 4060 11081 2588 4969 2331 2799 112937 3074 176 3073 4958 5549 79411 2720 89944 RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 95%5663213 RHO GTPases Activate WASPs and WAVEs 4690 10006 10458 51517 60 55845 644150 10810 5879 8976 8936 10787 10152 998 71 7454 5594 5595 7456 10109 10552 3071 10093 10092 10095 10094 10097 695 10163 10096 5747 147179 23191 25 26999 DEFECTIVE SLC3A1 CAUSES CYSTINURIA (CSNU)%REACTOME DATABASE ID RELEASE 95%5619113 Defective SLC3A1 causes cystinuria (CSNU) 11136 6519 ENTRY OF INFLUENZA VIRION INTO HOST CELL VIA ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 95%168275 Entry of Influenza Virion into Host Cell via Endocytosis 1213 1211 REGULATION OF CDH1 POSTTRANSLATIONAL PROCESSING AND TRAFFICKING TO PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 95%9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane 7841 23478 60559 5045 5046 28972 90701 1650 100128731 1499 6185 6184 29954 23193 58505 821 3728 5589 283106 746 1460 9159 10585 1603 3703 1459 1457 999 23396 9743 9789 288 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME DATABASE ID RELEASE 95%174417 Telomere C-strand (Lagging Strand) Synthesis 23649 5422 79991 5557 5558 54921 10714 5424 5425 5981 57804 3978 7486 5982 2237 5983 63922 80169 79075 5111 26277 25913 7013 641 65057 1763 7014 6117 54386 100134934 5984 5985 6119 6118 ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME%R-HSA-9028731.2 Activated NTRK2 signals through FRS2 and FRS3 10817 4915 4909 627 5781 6654 10818 4893 3265 DEFECTIVE MUTYH SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 95%9608287 Defective MUTYH substrate binding CRIZOTINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717326.3 crizotinib-resistant ALK mutants 238 TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 95%8963684 Tyrosine catabolism 2954 3081 6898 3242 2184 VITAMIN C (ASCORBATE) METABOLISM%REACTOME DATABASE ID RELEASE 95%196836 Vitamin C (ascorbate) metabolism 6515 6513 119391 9962 9963 9446 1727 1528 APOBEC3G MEDIATED RESISTANCE TO HIV-1 INFECTION%REACTOME DATABASE ID RELEASE 95%180689 APOBEC3G mediated resistance to HIV-1 infection 5478 3159 11168 8815 REGULATION OF THYROID HORMONE ACTIVITY%REACTOME%R-HSA-350864.4 Regulation of thyroid hormone activity 1735 1734 1733 VIRUS ASSEMBLY AND RELEASE%REACTOME DATABASE ID RELEASE 95%168268 Virus Assembly and Release 821 811 DEFECTIVE GALK1 CAUSES GALCT2%REACTOME%R-HSA-5609976.5 Defective GALK1 causes GALCT2 2584 CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME%R-HSA-173623.4 Classical antibody-mediated complement activation 716 1401 712 713 714 715 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 95%73884 Base Excision Repair 474382 4350 54145 2237 5423 11284 142 10714 5424 5425 5981 57804 3978 5982 56655 5983 7515 8970 8331 8337 5426 128312 5427 8334 3980 8335 4968 10038 8370 55766 54107 8341 5111 8342 8930 8347 8290 8348 55247 94239 8345 23583 26277 3013 252969 25913 8340 7013 65057 7014 8338 6117 255626 79661 5984 54386 5985 6996 6119 4913 3018 6118 3017 85236 3014 8505 54936 328 8349 MITOTIC G1 PHASE AND G1 S TRANSITION%REACTOME DATABASE ID RELEASE 95%453279 Mitotic G1 phase and G1 S transition 7298 7083 91750 993 132660 7465 286826 55957 5928 5933 5934 4605 6241 25 23649 5422 5557 5558 7027 1021 1019 894 896 1871 898 1870 6502 9134 1028 56655 1027 4149 7029 1869 5925 5426 5427 54107 208 5753 3065 1029 595 8317 1017 1876 1026 8318 1875 1874 29935 10926 55388 5519 4609 5515 5516 5518 9861 6233 4067 7316 10213 4331 1022 3717 5706 5707 5708 5709 207 5700 5701 891 5702 983 5704 5705 28227 5682 5683 5684 5685 902 5686 5717 5718 5719 5520 91768 11047 1030 5713 5714 5690 5691 5692 1032 5693 1031 5694 1163 7311 7979 5695 5111 7314 4172 8454 4173 4174 5687 4175 5688 4176 4171 5689 990 84515 51053 6117 10000 5000 5001 890 6119 8900 6500 23595 6118 1719 23594 81620 7153 4998 26271 4999 1859 RESISTANCE OF ERBB2 KD MUTANTS TO LAPATINIB%REACTOME DATABASE ID RELEASE 95%9665251 Resistance of ERBB2 KD mutants to lapatinib 11140 3320 2064 55914 SIGNALING BY FGFR%REACTOME%R-HSA-190236.4 Signaling by FGFR 2252 2251 8074 2249 2248 2247 2246 161742 152831 8823 5295 200734 2264 23767 143282 5290 5725 2255 23543 7049 54845 5515 9982 5516 5518 6233 80004 7073 7072 83888 7316 5440 4670 5441 3187 3185 673 5335 2963 2962 867 10755 5434 3730 5435 5436 5437 5438 5439 2591 22916 10817 5430 23768 4686 5431 23769 5432 5433 53834 10253 8569 5781 4893 27006 2549 7311 7314 5594 5595 10818 3178 8817 26281 9965 6654 2254 3265 DEFECTIVE CHST6 CAUSES MCDC1%REACTOME DATABASE ID RELEASE 95%3656225 Defective CHST6 causes MCDC1 176 4166 4958 5549 4060 11081 4969 2331 ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 95%112303 Electric Transmission Across Gap Junctions 10052 57369 84694 24145 56666 AXONAL GROWTH STIMULATION%REACTOME DATABASE ID RELEASE 95%209563 Axonal growth stimulation 396 4803 4804 387 REGULATION OF NFE2L2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%9818749 Regulation of NFE2L2 gene expression 2033 4851 4790 4780 5970 1387 4609 7975 ETHANOL OXIDATION%REACTOME%R-HSA-71384.5 Ethanol oxidation 125 128 216 217 130 131 219 124 126 84532 55902 127 EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS%REACTOME DATABASE ID RELEASE 95%168274 Export of Viral Ribonucleoproteins from Nucleus 23636 9631 7175 9972 11097 23279 8086 23511 53371 8480 79023 79902 10762 5903 5901 3304 348995 9883 6396 129401 9688 57122 7514 23225 4927 23165 55746 8021 55706 PAOS OXIDISE POLYAMINES TO AMINES%REACTOME%R-HSA-141334.4 PAOs oxidise polyamines to amines 196743 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA1 LOSS OF FUNCTION%REACTOME%R-HSA-9701192.4 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 7486 116028 472 10635 672 675 83990 7516 10111 5932 7979 4361 7156 5890 9156 5892 4683 580 10524 641 1763 79728 5888 80010 5889 RHOC GTPASE CYCLE%REACTOME%R-HSA-9013106.2 RHOC GTPase cycle 29 55914 23002 23263 9475 9217 114793 9639 55701 6093 93663 9138 4168 5295 11214 399693 115557 55219 5825 64283 2040 6811 91452 1729 2909 9743 2319 284119 57584 392 9341 394 8826 9414 708 11113 4650 3998 6793 5585 396 81839 5586 23092 91010 3728 54443 90627 55160 23365 10395 29127 57580 4983 613 29941 10211 857 3930 55789 6242 128239 7410 4162 7112 9748 7037 9826 80728 9828 387 81624 389 7984 SIGNALING BY RAS GTPASE MUTANTS%REACTOME DATABASE ID RELEASE 95%9753512 Signaling by RAS GTPase mutants 3845 4893 3265 SPECIFICATION OF THE NEURAL PLATE BORDER%REACTOME DATABASE ID RELEASE 95%9834899 Specification of the neural plate border 7022 7021 4602 2249 7020 652 83439 2637 1499 6657 89780 5081 1749 4487 7545 5460 5077 DEFECTIVE SLC24A5 CAUSES OCULOCUTANEOUS ALBINISM 6 (OCA6)%REACTOME DATABASE ID RELEASE 95%5619036 Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) 283652 POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME%R-HSA-8957275.2 Post-translational protein phosphorylation 10618 6696 7076 5611 718 3956 4924 3053 721 213 8614 335 3827 2519 336 375056 10272 174 1435 54972 3698 84141 8720 9210 11098 462 54587 7425 29106 7184 6694 334 1462 7018 338 10970 5768 3913 3895 3915 2335 80341 57719 3912 4052 652 3569 2200 102 8074 3371 11320 1000 4148 1758 6383 5589 4221 348 2719 2266 2243 57104 10130 54757 51246 5265 8404 2621 8542 1471 3491 3490 2153 5624 3488 3487 7466 351 64856 197 10117 1114 258 7857 11167 10232 5954 1356 56955 4240 4241 5179 255738 3270 265 401138 51156 5034 91851 147111 3486 51280 3484 56975 116519 813 FATTY ACID METABOLISM%REACTOME%R-HSA-8978868.7 Fatty acid metabolism 51102 23597 1582 1580 6584 79777 55289 1573 4056 641371 134526 6916 158833 5321 64174 1622 4706 91452 5730 27349 284541 1632 158584 80142 5740 37 126410 1558 1579 26027 3032 3030 5467 1557 1545 1544 113612 1543 8529 5742 1559 5743 1892 284486 2876 1666 80221 58488 22949 239 2879 59344 145482 47 9200 27306 9524 117145 79071 64834 3992 376497 2194 401494 23205 23305 79993 84869 873 253017 201562 51144 2166 55301 3248 11001 11000 55856 54898 5538 142827 31 197322 51703 2180 6256 6785 22880 5444 9374 3293 5264 2182 81616 2181 23600 51495 283927 4363 79966 83401 390916 3033 7923 109703458 60481 6319 5445 10728 5446 11332 8310 5563 2053 5565 30 8309 51422 10478 57834 122970 9261 10005 80724 1384 58526 1376 10449 788 1375 54677 4051 2678 4048 84320 2687 1374 3295 240 241 242 246 247 51179 414149 11283 8644 7069 33 215 34 35 55825 9536 9415 4594 166785 1800 6342 84693 26063 10965 1962 84129 2877 5096 26061 5095 6296 127281 XENOBIOTICS%REACTOME%R-HSA-211981.3 Xenobiotics 1557 57491 1544 1571 1543 1565 1559 1577 1553 405 1549 1576 1548 196 64816 1555 1551 1572 1573 1562 54905 9915 1558 29785 ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 95%9694614 Attachment and Entry 6382 5045 2239 2719 2817 375790 59272 26762 3339 6383 7415 221914 1514 8829 9672 10082 7113 6385 2262 FRS-MEDIATED FGFR1 SIGNALING%REACTOME%R-HSA-5654693.5 FRS-mediated FGFR1 signaling 27006 2255 2251 8074 2249 2248 2247 10818 2246 10817 26281 5781 6654 4893 2254 3265 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%R-HSA-205043.3 NRIF signals cell death from the nucleus 83464 51107 4803 7311 7314 4804 8878 6233 5599 23421 7316 5663 23385 7189 55851 5664 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190242 FGFR1 ligand binding and activation 27006 2255 2251 7049 8074 10755 2249 3730 2248 2247 2246 26281 2254 REGULATION OF NPAS4 GENE EXPRESSION%REACTOME%R-HSA-9768759.2 Regulation of NPAS4 gene expression 4343 6722 5978 192669 23112 27327 30818 26523 192670 27161 57690 2908 266743 SIGNALING BY TGFB FAMILY MEMBERS%REACTOME DATABASE ID RELEASE 95%9006936 Signaling by TGFB family members 4904 7076 5045 7046 7048 7040 10272 268 9241 51377 408 905 409 650 892 130399 91 7049 92 93 8928 5933 10589 10468 6925 4617 4618 6498 4654 4656 6497 50855 83855 3070 867 10755 7027 142 5499 7077 4091 9350 7029 50848 9958 5590 57530 56288 25937 4052 4054 2033 27302 10273 5594 5595 3696 3690 8425 23370 3685 6256 4323 4325 387 7043 5663 7042 23385 55851 5664 83464 5914 3693 51107 3694 3065 9110 2247 1875 1874 5054 23645 9612 5501 3688 9611 8516 4221 4609 4343 192669 23112 27327 8812 26523 5494 4613 57154 192670 27161 57690 7323 2280 6929 6233 4738 7316 7514 5500 51592 54778 22938 23439 7321 6938 4086 4087 4088 4089 9765 4090 7050 4093 657 658 659 94 64750 64388 2658 269 4092 1025 904 6667 1030 1024 7311 7314 3625 3624 60436 9040 3623 25805 56937 1278 11171 11167 3726 91851 8239 23327 PDGFR MUTANTS BIND TKIS%REACTOME%R-HSA-9674428.2 PDGFR mutants bind TKIs 5156 PREGNENOLONE BIOSYNTHESIS%REACTOME%R-HSA-196108.5 Pregnenolone biosynthesis 134429 231 6770 1583 10948 706 147323 112812 83930 2232 9256 2230 G2 M DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69473.7 G2 M DNA damage checkpoint 51588 54145 9656 7465 995 8924 7157 29086 51720 2810 11200 7534 165918 7468 891 7529 983 7158 7486 5982 5883 5884 5983 7334 116028 3364 8970 472 7336 9025 672 128312 84126 79184 1111 83990 10971 144715 83695 8370 5810 10111 5932 7532 8341 4361 8342 7531 7156 8347 8290 9156 8348 7533 8345 84142 4683 11073 9577 580 8340 10524 641 1763 545 6117 255626 5984 5985 890 6119 8900 3018 6118 3017 85236 80010 3014 8349 DEFECTIVE SLC12A6 CAUSES AGENESIS OF THE CORPUS CALLOSUM, WITH PERIPHERAL NEUROPATHY (ACCPN)%REACTOME%R-HSA-5619039.4 Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) 9990 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 95%176408 Regulation of APC C activators between G1 S and early anaphase 1017 9861 6233 7316 10213 8945 51529 7321 5706 8881 64682 5707 25906 5708 11065 8697 5709 7324 10393 29945 27338 119504 5700 5701 29882 891 5702 246184 983 996 5704 51343 51434 5705 51433 5347 5682 5683 5684 5685 5686 5717 9184 5718 5719 991 11047 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 8454 5687 5688 5689 4085 890 8900 6500 26271 701 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME%R-HSA-69166.4 Removal of the Flap Intermediate 23649 5422 5557 5558 5111 10714 5424 5425 57804 1763 2237 6117 6119 6118 LESTAURTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702596 lestaurtinib-resistant FLT3 mutants 2322 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%2691230 Signaling by NOTCH1 HD Domain Mutants in Cancer 28514 182 7311 7314 6233 9148 54492 4851 7316 142678 6868 3714 57534 102 54567 GABA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%888568 GABA synthesis 2572 2571 HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME%R-HSA-5685939.3 HDR through MMEJ (alt-NHEJ) 10038 10721 2237 10111 5932 7515 4361 142 675 5893 4683 3980 VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME%R-HSA-5218921.5 VEGFR2 mediated cell proliferation 5579 10768 5335 808 5580 8877 3710 3708 5578 5590 3709 3791 5921 4893 3265 5170 DISEASES ASSOCIATED WITH SURFACTANT METABOLISM%REACTOME%R-HSA-5687613.4 Diseases associated with surfactant metabolism 653509 729238 10568 6441 6440 6439 1439 21 1438 DEFECTIVE VWF BINDING TO COLLAGEN TYPE I%REACTOME%R-HSA-9845622.1 Defective VWF binding to collagen type I 7450 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%R-HSA-727802.6 Transport of nucleotide sugars 7355 23443 23169 55343 84912 51000 11046 10559 347734 CREB3 FACTORS ACTIVATE GENES%REACTOME%R-HSA-8874211.3 CREB3 factors activate genes 8720 10488 64764 90993 148327 84699 153222 81501 51360 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME DATABASE ID RELEASE 95%3296469 Defects in cobalamin (B12) metabolism 2694 326625 27249 25974 4594 166785 51293 6948 5826 4552 55788 81693 8029 4548 DEFECTIVE SLC6A2 CAUSES ORTHOSTATIC INTOLERANCE (OI)%REACTOME%R-HSA-5619109.4 Defective SLC6A2 causes orthostatic intolerance (OI) 6530 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME%R-HSA-212718.4 EGFR interacts with phospholipase C-gamma 255324 2069 1950 5335 1956 374 1839 7039 685 LATENT INFECTION - OTHER RESPONSES OF MTB TO PHAGOCYTOSIS%REACTOME%R-HSA-1222499.4 Latent infection - Other responses of Mtb to phagocytosis 4057 BIOLOGICAL OXIDATIONS%REACTOME%R-HSA-211859.4 Biological oxidations 23491 1312 1583 1582 1581 1580 1576 1573 1593 6916 1589 1588 1585 66002 64174 2328 9 10 80777 284541 5740 2232 126410 1558 1579 2230 1557 1545 10858 1544 113612 6822 1543 8529 5742 1559 10249 123876 341392 219970 92292 54988 389396 23169 11046 6818 10728 3326 79094 217 1594 1592 1591 340665 120227 56603 57834 9971 4552 51504 9049 9915 4051 9446 11283 2939 373156 51302 2944 2941 2949 2947 2946 7172 2953 2952 57412 1800 4144 221357 119391 2098 653689 196743 9420 54600 405 196 8459 26 8460 5443 2948 4548 1727 112812 57491 2950 27306 2938 27430 1571 2940 1565 7363 133688 7365 7364 7367 7366 7360 54490 80146 79799 54578 54577 6256 55347 54576 10327 574537 54575 54658 54657 54579 7358 167127 10941 10720 8648 54659 116285 348158 29104 2678 191 124975 2687 79017 2730 2686 494143 8574 22977 2954 55748 1577 26873 2729 1553 2937 4257 1584 91703 4258 4259 95 246181 216 10499 4143 124 126 4837 127 1066 54996 874 29785 285440 1595 13 125 128 2052 130 131 2327 2326 8824 55902 134147 5447 64757 670 314 4128 4129 54928 1549 10380 1548 6783 64816 391365 1555 25830 1551 6817 218 84836 219 6819 1572 27284 84532 445329 1562 27233 54905 6799 4835 50512 8639 METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME%R-HSA-6799990.3 Metal sequestration by antimicrobial proteins 338324 6280 6278 4057 6279 3934 LEWIS BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%9037629 Lewis blood group biosynthesis 30815 124872 2524 8707 8708 10690 2525 10402 2526 10317 8705 2529 2528 6484 2527 6487 BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME DATABASE ID RELEASE 95%141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB 4128 4129 ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME DATABASE ID RELEASE 95%392023 Adrenaline signalling through Alpha-2 adrenergic receptor 151 152 150 METABOLISM%REACTOME DATABASE ID RELEASE 95%1430728 Metabolism 5018 5244 55788 92259 28234 1836 6584 4706 1558 1579 1557 1545 1544 113612 1543 8529 1559 10249 123876 341392 219970 92292 54988 389396 11041 9469 26230 7498 64064 56898 38 54511 622 3158 65985 5019 2542 10728 26229 1594 1592 1591 340665 120227 56603 7329 23396 27068 2068 2793 2792 2791 1460 2790 1459 2788 1457 2787 2786 5464 2785 2784 2783 51764 9562 11163 23007 2629 55586 3613 170685 3612 23262 11165 3632 9630 3633 94235 117283 9651 5333 113026 9677 55190 84812 3705 3706 3707 51196 89869 55970 51477 3628 80271 54331 2767 59345 26330 471 2769 7157 2782 2776 10681 8877 348995 9883 6396 129401 9688 291 57122 23225 4927 23165 23408 55746 55706 23636 9631 7175 9972 11097 23279 8086 23511 53371 4082 6120 8480 79023 221823 79902 729020 10762 23729 5631 5903 25796 5634 64080 6232 2938 1728 2940 644 645 10327 51084 9942 6652 51181 253430 64768 51447 9807 5286 8898 8821 9896 55361 9110 22876 200576 54893 55300 54545 55697 3631 4534 5501 5519 5805 5515 2644 2643 5516 6697 5518 2203 8789 92579 54020 57818 5106 58526 5528 1376 788 1375 9600 1040 57605 83394 10423 65263 57494 29920 2746 27165 284716 2744 883 11081 2752 5831 8534 23563 4942 2806 93010 4969 2747 10678 8703 8704 8702 4166 9435 4958 216 79369 5549 51109 8644 124 126 127 2224 2222 3157 1595 6721 1717 10654 23576 6309 9453 114757 10434 4047 4520 3422 4598 6713 7108 54928 10380 6783 391365 25830 6817 84836 6819 27284 445329 27233 6799 5336 50512 3615 3614 1312 5906 5566 5567 11069 5568 10411 760 771 761 762 763 765 766 768 759 377677 23632 11238 4123 23324 9871 9 9632 10 131870 22978 11164 10427 10591 55270 93034 3704 56985 9615 1131 6230 6210 6231 6234 6235 6191 2197 6193 6192 6194 51065 140032 11261 6205 8692 6227 3038 6204 3037 6207 55576 6229 57214 6206 3036 6228 6677 10894 6209 6208 6188 6187 6223 6201 6189 6222 6203 6224 6202 443 6218 2346 6217 339983 3921 10003 374569 11285 126792 2646 2645 5409 7054 1644 1621 3326 5563 6794 5565 51422 10802 10484 2525 2944 2941 2949 2947 2946 7172 2953 2952 57412 4144 221357 119391 857 2098 653689 3930 4952 51293 6948 23743 58478 635 84245 55256 8459 8460 51070 10331 113189 132158 3795 6152 6155 6154 6157 9349 6156 6159 6158 23521 51121 11224 6164 200916 6166 6122 6165 6124 8826 6168 6123 6167 6169 6125 116832 25873 6160 6161 140801 4736 6130 6133 9045 6132 6176 6135 6134 6137 6136 5337 6171 6170 6173 6128 8976 6129 6142 6141 6144 6143 6146 6147 6181 6139 6138 51295 4060 375790 2331 176 3339 54797 55090 80306 23097 6837 6613 219541 23389 55588 9412 7167 5223 400569 5224 230 80201 283209 2821 29104 2027 2026 5214 5230 2678 5232 124975 3099 2687 79017 132789 2597 2730 2686 3101 494143 387712 55748 5210 5211 26873 5213 2729 2023 2937 10007 226 83440 229 669 5207 5208 5209 1066 1387 6667 113235 2875 1719 6833 3767 111 112 7298 113 114 115 7083 107 108 109 196883 1583 1582 1581 1580 22874 81846 126969 3638 201164 55326 1576 79777 1455 3710 80765 54477 4846 56894 1573 56895 340485 5593 3636 1593 6916 1589 55331 1588 79887 1103 7804 1585 79888 5321 1109 64174 1120 125981 10998 27063 147323 338 83930 114971 55224 5833 1119 5730 204219 100137049 80777 2778 149998 171546 3708 3709 25902 284541 10400 6573 160428 706 158584 2350 5740 441024 200895 2232 126410 81034 4522 2230 4524 123264 345275 10840 84803 1149 10797 10858 128486 57664 10588 161247 6822 6718 29923 63924 5742 5743 133121 284486 4899 5867 15 121278 6715 6716 438 3837 66036 137964 5868 22937 5641 114884 80339 80221 5261 10715 378884 8904 5260 8908 50814 22949 7957 83592 388121 5837 114876 81537 5255 120103 114879 5256 145482 5257 81544 2998 114880 2632 5507 441282 114881 114882 114883 866 23683 2592 6520 2274 25865 23446 873 51365 253558 8140 2166 3248 254531 55856 55613 142827 6539 166929 284161 6770 5322 5444 51141 80821 55500 84188 5319 25979 4363 200931 3033 55750 253782 8714 5445 5446 11332 9926 29095 56848 129642 8611 8612 6555 6554 5587 23760 23761 3284 3283 23646 54675 8034 8605 8875 6305 5168 6307 5169 3291 80025 23659 284439 3290 254552 123099 80347 3294 53354 51171 79877 3292 79646 51170 60496 57834 79717 55229 79603 60490 8613 8871 4036 80736 10558 211 55304 56994 151742 8867 10554 9971 5130 8760 25816 80724 221 222 171586 10449 6579 8879 10682 79626 5007 91734 9967 4051 8897 8895 590 142891 231 4048 84320 51763 126282 200879 63874 29956 64600 23179 240 241 242 5728 23171 246 247 248 414149 30814 11283 64850 5287 5288 9885 165679 377 51302 9517 33 34 35 5297 5298 9536 83884 9415 384 39 8560 5293 1800 51552 84693 54947 43 374986 9420 162466 84129 347516 51205 11145 65977 9791 23259 51573 54600 50486 9429 50487 6296 127281 10390 64419 56910 117245 51102 51588 1718 54979 11010 10162 23597 183 55711 85465 51478 2819 84498 91012 9107 9468 26279 10809 196 55289 27242 81579 26031 84725 27124 4830 22908 2948 641371 134526 158835 22925 7179 158833 56261 57110 204962 133686 27132 388931 36 1622 255189 2235 10948 283871 27034 9108 80230 8398 8399 375775 9489 255043 27349 10908 9362 79153 8226 8394 79152 7084 7371 8395 83549 283748 1632 54963 80142 112812 9256 26027 134429 57491 79143 1646 1645 122618 154141 9023 160728 403313 1892 81490 130367 284129 10861 57153 64801 259230 59339 59338 2876 1666 84879 124976 58488 50640 80270 151056 7416 2638 2879 94103 93492 59344 94101 27306 29841 3972 27430 3992 1571 123745 1565 1158 84895 6535 2531 6534 5920 2593 1152 1160 2628 6538 548596 48 51085 79602 51094 7299 1638 7306 5500 51805 57017 57107 56997 23590 10229 84842 79934 51004 51117 84274 122622 5471 5198 10606 158 159 8833 2618 5332 2642 2641 2683 7086 5499 23169 51000 11046 347734 26251 8884 376497 3790 150 152 3745 3747 217 10891 28976 4728 4729 27089 4720 137872 4723 4724 4725 4967 4726 25915 55572 4731 4947 51582 152100 93058 79814 6303 728294 51686 100996939 6723 3420 116228 4946 4190 262 28958 6611 4191 113451 4508 4953 55101 4509 1355 51660 51300 81857 1353 374291 10873 3419 10632 3418 4512 7352 4513 7351 4514 347411 6389 55471 4519 80775 54949 2110 119559 160287 81889 6391 6390 6392 2108 55245 10975 122961 2101 51204 2109 9551 4540 285521 501 4541 55349 6720 9556 29958 6834 1757 4535 6945 6861 84233 4536 58510 4537 8659 4538 5625 1024 7385 7384 7386 7388 80219 7381 83733 84701 25880 80224 51103 2805 4200 389203 509 284184 4694 4695 4696 2271 79133 57226 51241 126328 513 8802 514 515 10131 8803 55967 517 8801 518 55969 25994 25874 84833 1743 81689 10498 521 522 29796 440957 57001 92483 405 644096 9481 27109 6515 84987 406 10025 57128 100303755 55744 55863 5443 148811 539 10476 790955 1081 54539 91942 9016 892 728568 3948 79944 2739 3945 90871 341947 440567 23530 3052 29078 10001 90624 100131801 137682 192286 751071 4705 5465 79751 4707 4708 4709 135154 84300 4700 4701 4702 4704 6341 8402 79064 4716 29079 493753 4717 5467 7372 4718 5468 790 4719 5469 1723 51079 4710 4711 4712 4713 54902 4715 7421 9862 25939 259307 5860 5092 80150 130589 84246 3081 6898 50484 3242 2184 9443 9441 9442 3906 9440 115677 316 55163 27087 51586 2584 2582 9439 124872 8707 9917 8708 10690 92370 64131 64132 2526 10317 2529 2528 135152 2527 144193 57571 131669 7296 3067 9477 3034 138199 10841 112950 8574 22977 1577 1553 7295 4257 91703 4258 4259 95 246181 8396 1514 152926 26275 549 3712 4800 4801 4802 2877 9282 1327 2653 1329 1340 1337 1339 1351 1350 1349 1347 1346 1345 2987 123688 51166 55526 89874 10157 2639 1428 9962 6616 9963 1528 64077 81894 125965 56474 8942 11112 51151 10243 10247 203 204 205 212 5498 83594 23057 8564 275 23498 23475 64428 128240 1503 27010 92014 64802 79077 122481 4682 57678 27158 158067 51647 125061 51218 7389 7390 221264 9583 26289 1635 55191 79178 377841 130013 6604 55328 4329 6999 4338 55739 64210 613227 25961 5053 80704 57089 51312 9673 27231 51727 4832 4833 2548 1352 1371 169355 952 954 2799 955 956 51003 55034 349565 3145 10101 65220 586 10135 587 10560 5834 6240 60386 5836 54981 1841 56267 112817 2731 9380 4697 2745 102157402 9391 9390 27304 5305 4948 3620 2588 6947 960 79837 978 9915 55276 4125 4126 23410 683 8876 210 5236 51071 9968 9969 26 8566 6241 9997 178 7276 1727 2950 93100 2992 4831 7363 133688 9572 7365 7364 90809 7367 7366 7360 54490 80146 79799 54578 54577 55347 54576 574537 54575 54658 54657 54579 7358 167127 10941 10720 90390 6095 9377 133522 9167 57515 10955 256987 113675 619189 26227 2539 5723 2538 10993 347735 29968 63826 6548 594 10295 1629 1738 593 26119 51360 338328 51128 81693 51129 4023 776 8029 116519 9254 23491 783 213 335 336 337 7166 8720 3949 345 1785 5167 55312 113278 80308 55065 79581 54 66002 7350 3028 161823 4860 270 271 3251 272 51292 132 100 353 1633 2766 1716 10057 239 5573 5575 5576 5577 22 5330 5331 4907 953 957 23236 56953 7378 151531 1890 1807 1806 51733 84618 64902 30833 2058 9227 5950 5947 28 326625 5901 4552 51504 51750 2694 27249 25974 4035 29967 154807 83875 7274 79001 29914 5948 26020 54884 57016 53630 5406 55937 1208 10090 29940 51363 92126 340481 56623 9663 8694 392636 2173 2171 2170 80168 84649 2820 2169 116255 2168 2167 150379 8228 346606 11343 646486 3991 64900 646480 2713 2712 2710 51099 150763 23175 10226 123 23054 5166 8202 948 26007 11185 191 118672 51520 875 1615 22928 3376 51091 7965 9521 51540 9255 6301 1491 27232 57104 60678 5859 4141 8800 4143 10499 3176 79048 5917 3735 4837 7069 54996 874 29785 285440 13 125 128 9370 2052 130 131 2327 2326 8824 55902 79611 134147 5447 64757 670 314 4128 4129 1549 1548 64816 1555 1551 218 219 10555 1572 84532 1562 54905 5660 4835 8639 7368 339221 84002 53947 57704 285362 9514 2760 79642 56624 25870 2717 4074 340075 6610 6609 2524 410 2523 412 414 415 55627 416 8705 8706 9334 22901 9331 64781 153642 7357 2583 2581 57733 22934 55512 347527 427 143 56965 83666 84875 79668 54956 54625 2328 660 6818 51074 4836 5226 9061 9060 9348 64579 64711 2131 3340 90161 222537 10855 26035 9957 60495 9955 6448 9956 8509 4669 6383 221914 9653 266722 223 9672 8424 10082 6385 55217 9953 6470 9951 2262 6382 9394 2239 2137 2135 2719 2817 50506 7252 53905 405753 51061 7173 1734 1733 389434 90527 6528 1735 3635 146850 5294 23533 6175 9049 9446 4507 2997 375 3313 6888 6007 6006 2939 10768 4594 166785 64087 5096 686 5091 56922 3141 32 5095 6812 2864 773 4722 777 784 91452 4548 7263 25828 23474 58472 339896 100131187 51380 5783 1468 1036 6821 4357 84890 4698 2740 3163 5338 8503 117145 3630 6472 8776 30849 5289 9217 57761 5295 5296 5290 5291 116285 348158 3954 808 5162 5163 5164 5165 23409 64795 4199 4750 64777 8050 5160 5161 57546 55066 3939 79018 54994 10296 1737 4289 25852 2954 80232 10048 54704 1584 3161 83990 22856 337876 55501 50515 55790 54480 166012 79586 55454 7979 56548 162417 445 435 1373 10166 5009 57407 383 775 51248 5320 5646 47 9200 9524 79071 64834 2194 401494 23205 23305 79993 84869 253017 201562 51144 55301 11001 11000 54898 5538 5644 31 197322 51703 2180 6785 22880 9374 3293 2182 5264 81616 2395 2181 23600 51495 79966 283927 1610 83401 390916 7923 85007 109703458 8528 60481 6319 1504 516 9218 6901 25942 150274 8540 5827 54363 440387 79094 8310 2053 3417 440 498 51268 30 8309 6804 10478 8443 3155 122970 27235 9861 3421 6233 29090 9261 10005 1384 7316 5578 3162 10213 54677 8604 8021 5706 50 5707 5708 90639 1537 5709 10063 207 5700 3295 5701 5702 5704 5705 51179 5682 5683 5684 5685 5686 373156 5717 5718 5719 570 11047 215 5713 1431 5714 5690 55825 5691 6844 5692 5693 617 5694 7311 5695 6342 7314 26063 10965 196743 5687 5688 189 1962 5689 10165 506 26061 4714 54205 79644 4056 1462 2990 23553 3373 112937 8372 3074 3073 63827 1634 1586 3425 79411 411 2720 3423 633 1464 89944 1463 10675 9397 37 3032 3030 3320 5335 5424 2033 6256 6257 2172 6907 8648 54659 79718 7376 9612 10062 8841 9611 19 9495 344 2874 348 5346 5105 29906 81849 6483 2771 2770 6482 6484 6487 5476 3098 10825 4862 1374 30815 80205 4597 85441 96764 9575 8647 8869 6513 26503 6514 5826 4758 10402 10599 4759 1244 APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME DATABASE ID RELEASE 95%351906 Apoptotic cleavage of cell adhesion proteins 5317 1832 100506658 1830 9414 999 7082 1829 836 1499 1828 THE FATTY ACID CYCLING MODEL%REACTOME DATABASE ID RELEASE 95%167826 The fatty acid cycling model 9481 7352 7351 7350 9016 FORMATION OF LATERAL PLATE MESODERM%REACTOME DATABASE ID RELEASE 95%9758920 Formation of lateral plate mesoderm 652 6469 2294 3549 2626 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 95%432720 Lysosome Vesicle Biogenesis 8673 6456 81567 6845 4074 9146 1777 2799 1522 10053 2647 8907 9179 8905 130340 1174 162 1785 164 408 27243 1212 10717 8906 6844 351 23431 9829 1213 1211 3312 134829 157807 11154 375 INSERTION OF TAIL-ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE%REACTOME%R-HSA-9609523.4 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 819 6449 2010 6844 9218 51608 27230 10952 8266 351 6811 7485 5621 9381 3162 7917 23480 439 6804 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NTHL1%REACTOME DATABASE ID RELEASE 95%9616333 Defective Base Excision Repair Associated with NTHL1 4913 DEFECTIVE F8 SULFATION AT Y1699%REACTOME%R-HSA-9674519.2 Defective F8 sulfation at Y1699 2157 8459 8460 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 95%418990 Adherens junctions interactions 5928 1785 5931 288 29954 10585 283 1508 7841 7088 3065 1650 100128731 1499 6185 6184 23193 58505 821 5589 746 1603 3703 4609 4343 192669 23112 27327 999 26523 6591 4613 192670 116092 27161 7020 3170 94234 57690 23396 93986 9861 6929 55810 6233 687 79872 7750 348262 10009 7316 10213 9743 4193 5706 6938 5707 5708 5709 5700 5701 5702 1520 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 1460 11047 5713 5315 1459 5714 5690 5691 1457 5692 5693 5694 7311 5695 7314 5687 5688 5817 5819 5689 23411 9789 23478 60559 5045 2146 28972 5046 90701 283106 9159 81607 27085 5818 57863 1013 23705 1010 1008 1007 1003 8726 1005 1004 1001 1002 1016 1015 1012 253559 25945 1488 1487 5925 8970 3728 8331 8337 128312 8334 9314 8335 6597 8370 55766 54971 8968 8341 8342 5594 8347 5595 28513 8348 2294 7764 117581 94239 80149 8345 56978 3013 9839 8728 8340 6663 1495 64403 8338 27319 80332 255626 1006 1500 3224 3021 3609 653604 6615 3018 1009 3017 85236 3014 8349 474382 54145 2060 1000 23028 6935 8289 387893 3066 23512 6714 7414 54737 7291 10399 1514 6667 7490 7979 60436 11171 26508 51129 EML4 AND NUDC IN MITOTIC SPINDLE FORMATION%REACTOME DATABASE ID RELEASE 95%9648025 EML4 and NUDC in mitotic spindle formation 54821 378708 1781 23122 1780 27436 79172 1778 81930 55920 84643 3796 9793 91687 57551 79682 5905 1783 5501 83540 80152 2491 5519 332 55143 699 11243 3619 140735 5515 11004 5516 5518 9212 25936 11130 64946 79980 348995 10726 6396 5525 5526 55839 5527 5528 7514 57122 5529 55746 23279 79023 79902 5903 54908 6232 8655 5347 25909 8379 9183 1063 1062 9184 1060 991 151648 55166 1058 79019 151246 9735 23332 79003 55055 81565 22919 348235 5048 23421 220134 57082 57405 140609 51143 91754 147841 10783 4085 64105 401541 10403 6249 54820 80776 701 G BETA:GAMMA SIGNALLING THROUGH BTK%REACTOME DATABASE ID RELEASE 95%8964315 G beta:gamma signalling through BTK 2782 2788 2787 2786 55970 2785 2784 2783 51764 10681 54331 695 59345 94235 2793 2792 2791 2790 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-HSA-975163.3 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation 7311 7314 23643 7099 6233 353376 3656 257397 6885 23118 10454 7316 929 7189 148022 ADORA2B MEDIATED ANTI-INFLAMMATORY CYTOKINES PRODUCTION%REACTOME DATABASE ID RELEASE 95%9660821 ADORA2B mediated anti-inflammatory cytokines production 113 114 115 107 108 55970 109 196883 5566 5567 5568 54331 136 59345 2793 2781 2792 5573 346562 5575 2791 5576 5577 2790 5613 2788 2782 2787 2786 2785 2784 2783 3569 51764 10681 2778 2771 2770 94235 111 112 2773 DEFECTIVE SLC2A2 CAUSES FANCONI-BICKEL SYNDROME (FBS)%REACTOME DATABASE ID RELEASE 95%5619098 Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) 6514 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 95%69206 G1 S Transition 7298 7083 91750 993 132660 7465 286826 55957 5928 5933 5934 6241 23649 5422 5557 5558 7027 1019 898 6502 9134 56655 1027 4149 7029 1869 5925 5426 5427 54107 208 5753 3065 595 8317 1017 1876 1026 8318 1875 1874 29935 10926 55388 5519 4609 5515 5516 5518 9861 6233 7316 10213 4331 1022 5706 5707 5708 5709 207 5700 5701 891 5702 983 5704 5705 28227 5682 5683 5684 5685 902 5686 5717 5718 5719 91768 11047 5713 5714 5690 5691 5692 5693 5694 1163 7311 7979 5695 5111 7314 4172 8454 4173 4174 5687 4175 5688 4176 4171 5689 990 84515 51053 6117 10000 5000 5001 890 6119 8900 6500 23595 6118 1719 23594 81620 4998 26271 4999 SIGNALING BY ERBB4%REACTOME DATABASE ID RELEASE 95%1236394 Signaling by ERBB4 83464 51107 2562 2561 2560 6678 2554 11059 23118 6868 5295 2567 2566 6464 9611 10413 5290 55879 10608 348 51741 6387 11033 6233 3084 1742 3925 4734 7316 1447 6714 1950 6776 1956 5241 83737 2099 4893 7311 9542 10718 7314 145957 685 2069 2670 1839 5663 6285 6654 23385 55851 5664 3265 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME%R-HSA-446107.3 Type I hemidesmosome assembly 3918 3655 3909 977 5339 3914 3691 667 1308 MRNA EDITING: A TO I CONVERSION%REACTOME DATABASE ID RELEASE 95%75064 mRNA Editing: A to I Conversion 103 104 FORMATION OF INTERMEDIATE MESODERM%REACTOME DATABASE ID RELEASE 95%9761174 Formation of intermediate mesoderm 5076 3975 652 2296 7849 2247 130497 2303 PROTEIN REPAIR%REACTOME DATABASE ID RELEASE 95%5676934 Protein repair 22921 4482 5110 253827 51734 7295 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%R-HSA-204174.5 Regulation of pyruvate dehydrogenase (PDH) complex 57546 55066 5166 1737 2954 1738 54704 5162 5163 5164 5165 23409 8050 5160 5161 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 95%6783310 Fanconi Anemia Pathway 378708 146956 197342 7398 84464 80198 79008 2072 57599 2177 2176 29089 84126 201254 2067 7311 7314 64858 6233 22909 9937 353497 199990 55120 2189 545 91442 6117 7316 80233 2175 55215 2188 6119 2187 57697 2178 6118 UPTAKE AND FUNCTION OF DIPHTHERIA TOXIN%REACTOME%R-HSA-5336415.3 Uptake and function of diphtheria toxin 7296 3320 1938 1839 3326 928 DECTIN-2 FAMILY%REACTOME DATABASE ID RELEASE 95%5621480 Dectin-2 family 338339 143662 2207 118430 4582 4583 2534 6850 4584 4585 4586 200958 56667 727897 10071 94025 140453 4588 4589 170482 283463 4067 394263 26253 50856 10462 93978 5336 FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME%R-HSA-72689.3 Formation of a pool of free 40S subunits 6152 6155 6154 6157 9349 6156 6159 6158 23521 51121 11224 6164 200916 6166 6122 6165 6124 6168 6123 6167 6169 6125 116832 25873 6160 6161 140801 4736 6130 6133 9045 6230 6232 6132 6210 6176 6231 6135 6234 6134 6235 6137 6191 6136 2197 6193 6171 6192 6170 6194 6173 6128 51065 6129 140032 6142 6205 6227 6141 6144 6204 6143 6207 6229 6146 6147 6206 6228 6181 6139 6138 6209 6208 6188 6187 6223 6201 6189 6222 6203 6224 6202 6218 6217 3921 8662 8663 8661 8666 8667 8664 8665 27335 3646 51386 8668 8669 10480 1964 6233 6175 7311 RHO GTPASES ACTIVATE PAKS%REACTOME DATABASE ID RELEASE 95%5627123 RHO GTPases activate PAKs 4638 998 4771 808 4660 5063 2017 10398 2316 5879 4628 79784 5058 4629 5500 3984 103910 4659 4637 4627 5062 NTRK2 ACTIVATES RAC1%REACTOME%R-HSA-9032759.2 NTRK2 activates RAC1 5879 4915 627 1795 DEFECTIVE SLC35D1 CAUSES SCHBCKD%REACTOME%R-HSA-5579020.4 Defective SLC35D1 causes SCHBCKD 23169 SARS-COV-2 MODULATES HOST TRANSLATION MACHINERY%REACTOME DATABASE ID RELEASE 95%9754678 SARS-CoV-2 modulates host translation machinery 79760 6607 79833 11218 25929 6233 54960 8487 50628 6230 6232 6210 6231 6234 6235 6191 2197 6193 6192 6194 6632 51065 140032 6205 6227 6204 6207 6229 6206 6228 6209 6208 6188 6187 6628 6223 6201 6189 6222 6203 6224 6202 6218 6634 6217 3921 6633 6636 6635 6637 G2 PHASE%REACTOME DATABASE ID RELEASE 95%68911 G2 Phase 890 8900 1869 1017 1871 METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES%REACTOME%R-HSA-5579029.5 Metabolic disorders of biological oxidation enzymes 1545 2678 113612 191 2730 1583 26873 2729 2937 1584 95 4143 23169 1594 1591 340665 1593 120227 6916 1589 56603 1588 7172 1585 9420 2328 4128 1586 54658 54657 2232 112812 126410 2230 PYROPHOSPHATE HYDROLYSIS%REACTOME%R-HSA-71737.5 Pyrophosphate hydrolysis 5464 27068 64077 SIGNALING BY LTK%REACTOME DATABASE ID RELEASE 95%9842663 Signaling by LTK 3667 285016 2885 5295 5296 4058 10188 389658 6654 5290 5291 G BETA:GAMMA SIGNALLING THROUGH CDC42%REACTOME DATABASE ID RELEASE 95%8964616 G beta:gamma signalling through CDC42 998 2782 2788 2787 2786 55970 2785 2784 2783 51764 10681 9459 54331 5058 59345 94235 2793 2792 2791 2790 DIFFERENTIATION OF T CELLS%REACTOME DATABASE ID RELEASE 95%9945266 Differentiation of T cells 4772 861 6348 30009 864 8459 3458 6775 3595 7124 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME DATABASE ID RELEASE 95%2564830 Cytosolic iron-sulfur cluster assembly 22 51750 9391 64428 10101 2068 4682 27158 51647 5424 64210 83990 VIRAL INFECTION PATHWAYS%REACTOME%R-HSA-9824446.5 Viral Infection Pathways 5611 721 5928 905 55763 8729 5931 712 716 722 725 1108 23479 4869 5970 7334 10971 5978 51311 10294 7409 2288 57459 3839 2633 402569 10728 3840 3459 3841 3460 23601 3551 6872 6874 6873 51003 5879 2237 6880 6883 6882 6884 945 7341 55615 29108 6875 6878 8812 6877 7329 6879 9978 6921 6923 5869 7428 5440 8732 5878 5441 4331 8731 1022 2071 2966 6829 2965 4318 2963 6993 2962 2068 5434 5435 5436 5437 5438 5439 2968 2967 404672 5430 5431 138474 5432 5433 902 1460 1459 1457 7532 7531 7533 684 11314 5371 9968 9969 129685 6238 348995 9883 6396 129401 29959 9688 291 292 57122 293 23225 3836 4927 3159 3843 23165 11168 55746 55706 23636 253260 9631 7175 9972 11097 23279 8086 23511 53371 8480 79023 79902 142 10762 8815 5903 53615 6232 8655 1654 2908 51143 1147 90390 1781 83860 1780 1778 57551 5905 1783 5501 3688 140735 3717 8178 22916 25920 4686 51224 6924 7936 6827 6749 9150 6917 1025 51497 2534 7469 6850 3055 11198 3932 904 2621 2147 5627 1213 1211 51128 6500 5034 51284 3718 3554 5336 160 30011 161 6773 2926 163 3615 3614 29760 51185 1312 973 23186 974 335 3454 10280 5133 23476 59272 25855 10800 5926 10362 51317 1175 1173 3069 7318 7317 10533 84313 51028 11267 9871 5119 10951 9632 7335 9641 3665 10427 8945 57504 9112 7448 811 6230 6210 6231 6234 6235 6191 22863 2197 6193 6192 6194 55236 51065 140032 6205 6227 6204 6207 6229 6206 6228 1915 6209 6208 6188 6187 6223 6201 6189 6222 6203 6224 6202 3178 6218 3480 6217 3921 2923 3326 3107 3106 23352 57521 3134 3133 558 1977 10525 64223 5901 2280 2475 9246 203068 5062 3135 4360 10802 10484 25777 4751 10333 9039 8065 857 79876 63982 51191 203859 2589 7113 6733 476 57101 477 478 53822 7040 53826 55048 53828 89853 1104 51534 9525 137492 338440 27183 480 51271 51160 481 155382 93343 7251 79720 482 483 5902 486 51510 115004 55107 5648 2547 7520 3981 7518 80143 6152 6155 6154 6157 9349 6156 6159 55129 6158 23521 50636 51121 11224 6164 200916 6166 6122 6165 6124 6168 6123 196527 57719 6167 6169 5348 6125 5349 116832 25873 6160 6161 140801 4736 6130 6133 9045 6132 6176 121601 6135 6134 6137 9532 6136 6171 6170 6173 6128 6129 4691 6142 6141 6144 6143 6146 6147 6181 6139 1052 6138 23168 79577 80349 123169 9646 54623 8829 4793 375790 3656 257397 23118 3339 10313 79760 91662 27072 84818 4131 6607 3442 23339 3441 9908 10146 25820 3440 1107 79833 11218 54797 5610 23765 10332 6441 11311 55090 3452 4153 3066 3451 25929 80306 5479 3449 7555 3448 10207 3447 23512 57617 64601 4939 3446 23367 3445 26762 23097 54960 3444 55823 3443 11123 6837 8487 7284 219541 65082 23389 2932 3456 9111 1452 55588 79685 92359 9636 50628 9412 26007 1524 3605 400569 112744 8974 30835 54431 283208 51726 5033 10527 8819 4780 598 1387 6667 5777 2002 10000 54463 51742 5593 143 2931 56965 83666 84875 79668 54956 54625 79643 51652 197259 929 91782 2339 92421 3837 26276 5868 11035 22937 27243 128866 55666 10134 10015 29082 9685 25978 23643 7099 4836 84061 11282 7841 29801 25921 253832 51201 55741 1650 11320 51125 4247 51304 100128731 4249 6185 10461 7991 4124 4245 6184 25834 23193 58505 201595 6383 2530 221914 79844 821 11253 9672 5589 51114 10082 6385 746 1603 3703 2262 6382 2239 2719 2817 8767 57506 4067 695 9868 6175 8678 375 3716 5478 7353 4088 4089 7297 114548 1982 8672 317649 3838 89122 4792 10392 317772 23586 85235 64426 9789 23478 7706 60559 28972 90701 84282 6881 6885 7187 7189 221613 2697 92815 10454 8969 9817 440689 64127 4690 8737 51616 64135 7415 5781 8517 51606 30849 51639 53938 8896 81608 208 10898 23283 51645 5289 6654 24148 55696 55339 10945 1479 1478 1477 85437 23020 85313 10992 9879 9410 8683 10084 11051 9775 5295 5725 10523 5170 9785 54106 10291 7098 10978 199746 53981 9416 8449 9382 1794 10181 8106 51692 815 7852 1234 57794 5500 816 10189 4670 817 22938 818 51340 51585 22826 22827 10284 10283 8241 5093 5094 51593 23350 10286 10285 988 9343 6632 57461 84844 56259 51362 6627 6629 7979 6628 220988 10262 10946 23450 23451 54883 6634 56949 6633 6636 5546 6635 6638 6637 10907 9360 4904 10914 10594 10236 11325 55749 27238 10921 11338 29894 3309 6430 6432 6431 1660 8175 23524 1655 10450 6427 6426 9076 6429 57703 7097 6428 7096 1191 8189 51729 5356 27339 1665 920 84991 10465 3181 3188 3187 3185 3184 1901 2521 9716 51503 10421 3192 285755 3191 11100 64225 3190 689 5499 440400 1993 9295 4666 91937 550 83443 7301 7307 4061 51234 22924 10949 2961 2960 2959 2958 2957 2194 3065 1499 5824 6908 9861 6233 3654 3312 7316 7514 10213 7534 81857 8021 5706 5707 5708 5709 1981 207 5700 5701 5702 7529 5704 5705 5682 5683 5684 5685 5686 80273 5717 834 5718 5719 3676 1994 11047 5713 5714 5690 5691 5692 1024 5693 5694 7311 5695 7314 4790 26986 54464 3304 10965 5687 5688 5689 79109 23327 2146 5045 7431 9475 8452 10250 9844 27316 10053 8907 8905 6093 130340 3183 1174 10025 162 55690 79869 164 6772 3105 940 567 926 64398 892 3661 340061 29110 3276 81030 10001 81631 7405 8726 29079 9397 2342 5469 3320 1956 3978 1616 54457 5925 8970 8331 8337 128312 9862 8334 8335 2033 8370 1974 1973 8968 8341 8342 8347 8348 8345 3013 3570 8340 8338 255626 6732 653604 3018 3017 85236 6886 8349 861 54815 23028 6907 79718 84246 9612 8841 9611 9443 9441 9442 2874 9440 51586 9439 10155 10610 2810 6483 6482 6484 6487 9219 9477 6480 112950 256435 8148 83737 8813 27090 8818 1514 7082 54344 9282 ION TRANSPORT BY P-TYPE ATPASES%REACTOME%R-HSA-936837.6 Ion transport by P-type ATPases 478 479 51761 53822 53826 53828 286410 57198 480 481 57194 482 483 486 487 51248 488 489 495 496 9914 6717 10079 490 491 808 492 57130 493 540 5205 23400 374868 815 23120 816 5350 817 84239 818 23250 5348 5349 57205 344905 10396 538 6588 148229 27032 51076 23200 476 79895 477 DEFECTIVE PRO-SFTPB CAUSES SMDP1 AND RDS%REACTOME DATABASE ID RELEASE 95%5688031 Defective pro-SFTPB causes SMDP1 and RDS 6439 MIDOSTAURIN-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702600 midostaurin-resistant FLT3 mutants 2322 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME DATABASE ID RELEASE 95%170670 Adenylate cyclase inhibitory pathway 113 114 115 2774 107 108 109 196883 2771 2770 346562 111 112 2773 NERVOUS SYSTEM DEVELOPMENT%REACTOME%R-HSA-9675108.3 Nervous system development 1759 8218 4313 10570 1809 56896 1400 1808 4099 53358 26052 6386 5453 6709 90249 1605 5979 7204 23365 219699 10451 7410 25791 9826 5598 91584 102 5663 8997 23385 55851 6453 5664 83464 8874 51107 5879 6383 7074 6655 2817 5362 10371 6478 2242 23396 8453 6237 55558 9978 4067 6921 6923 6175 2064 4318 23032 1072 5788 4478 8851 5306 1460 1459 1457 8861 5293 6197 6196 9252 6195 3672 7525 5588 3670 7305 85358 60 84059 4359 57716 4155 57211 3156 5376 64283 782 784 785 27289 6711 23114 25 4690 6232 5781 4893 5361 5364 8503 998 9855 2549 23332 8660 5594 5595 10818 6663 23380 8440 24137 387 388 6654 389 23129 3265 23122 2887 5454 5216 5217 9775 5295 3688 5296 55110 6464 5290 5291 9846 51466 71 6387 2886 1742 1741 1793 1739 7852 2904 6714 2902 285643 286 4897 6900 55740 8828 10048 7094 22916 4686 2534 4651 1595 6721 7979 1213 1211 7436 2668 2676 2675 2674 776 10752 160 30011 285220 161 4753 4756 7430 163 6708 57556 100133941 2596 6710 783 5623 6712 971 5962 148738 5909 137970 5566 64096 5567 4440 10921 57698 5568 5649 2045 2044 2043 10487 4628 1175 2042 79784 1173 2041 4116 4629 5786 10507 116986 1785 64218 3984 775 3985 2046 103910 4637 4664 779 4627 4665 56956 56963 1959 22794 23767 8986 6324 6477 6323 11313 1286 89884 1285 54209 7220 6331 256076 6330 7222 9939 8633 7224 9723 7223 6332 5365 7225 6335 6334 214 6326 8506 131873 6328 6327 6329 6586 1293 6585 1292 3199 1291 57731 6336 23053 11280 57113 7408 59277 220164 55800 65109 8650 1943 287 1287 2051 1942 3915 2050 288 2049 51332 2048 1946 284217 2047 1945 1949 55816 3908 1948 1944 1947 10154 8482 1600 55715 3912 8515 9355 8022 27255 6092 4902 1641 9260 284656 6230 80031 6210 9048 6231 9046 6234 285704 6235 6191 2197 6193 6192 6194 51065 140032 5576 6205 6227 6204 6207 6229 6206 6228 6209 6208 1821 6188 6187 6223 6201 6189 3785 6222 3786 6203 6224 5532 6202 6218 6217 3921 79966 4233 1272 3326 7402 10627 8912 8913 10413 8911 9861 6233 3312 7316 5578 10213 2909 5062 5706 5707 5708 5709 1981 5700 5701 1020 5702 10298 5704 5705 5682 5683 5621 5684 5685 5686 5717 5718 5719 11047 5713 27 5714 5690 5691 5692 5693 5694 7311 5695 7314 26986 5687 5688 5689 5058 28964 80728 1969 9475 6093 57453 1630 9423 1826 1284 1282 27330 6152 6155 6154 9901 6157 9349 6156 6159 6158 23521 51121 11224 57522 6164 1463 200916 6166 6122 6165 6124 6168 3320 6123 6167 5335 6169 6125 116832 1956 25873 6160 6161 9353 140801 6091 4736 5063 4650 6130 6133 57144 9045 6132 6176 6135 6134 6137 6136 1796 6171 9037 6170 6173 25937 6128 8976 6129 5921 6142 6141 6144 6143 6597 6146 6147 6181 6139 6138 56924 3690 3680 4684 3685 3674 3897 3678 8829 5604 5605 1299 1298 6456 375790 7003 3673 1297 22885 84448 9495 3983 1212 3066 10398 10109 10552 10093 10092 10095 10094 2932 10097 10096 2107 23708 10486 2935 26019 65110 8128 7903 5747 VPU MEDIATED DEGRADATION OF CD4%REACTOME DATABASE ID RELEASE 95%180534 Vpu mediated degradation of CD4 5706 5707 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 9861 6233 5687 5688 5689 920 7316 6500 10213 8945 DISEASES OF METABOLISM%REACTOME%R-HSA-5668914.11 Diseases of metabolism 435 1373 10166 5009 57407 383 1583 55788 1836 10568 1593 6916 1589 22934 1588 1585 2328 2232 126410 2230 11093 1545 113612 6440 2683 4860 3251 11041 9215 29954 100 353 378884 23169 8908 7957 10585 55624 2998 1605 2632 5507 2592 9469 38 31 4851 4853 4854 11285 4855 126792 2542 5053 7841 9060 26229 2548 2131 4247 2799 6448 4669 6383 3417 221914 11253 1594 9672 10082 1591 6385 340665 120227 2262 56603 6382 2239 326625 2719 2817 2588 6233 4552 7316 2997 6888 653509 6439 2694 27249 7172 25974 4594 7311 166785 7314 9420 64087 5096 686 5091 56922 3141 5095 79644 5236 51293 6948 138050 5443 56667 1462 2990 3373 113189 3795 3074 3073 63827 1634 1586 3425 411 2720 1439 3423 633 1438 1464 1463 4548 112812 10675 1892 4158 145173 57188 2591 143662 79695 10417 118430 10418 170689 171019 54437 9510 9037 4582 5199 2992 4583 7058 4584 4585 4586 200958 157869 727897 29071 9507 140766 80070 9508 9509 10071 94025 339366 221981 79875 81794 140453 55901 4588 4589 81792 283463 9719 56999 56913 394263 11173 54658 11096 54657 51181 11095 11174 80731 170690 54507 170692 92949 170691 4060 375790 2331 130589 176 3339 6441 21 2584 92579 2582 56052 440138 79053 22845 6487 2538 5476 10020 79087 2678 191 7057 2730 11081 2673 8813 26873 4969 2729 2937 3938 6476 1584 85365 8818 95 4166 229 29929 4351 4958 10195 5549 4143 152926 26275 549 3712 1798 79796 22856 91869 729238 116150 5373 594 10295 1629 3955 1738 593 5826 199857 54344 79868 9526 4128 79947 4758 81693 8029 162417 445 INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-HSA-6783589.8 Interleukin-6 family signaling 3716 386653 3976 1489 5008 867 3572 3977 9021 1271 1270 7297 3590 3569 3589 3570 23529 6774 6772 5781 9180 133396 9244 3717 FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME%R-HSA-5658623.4 FGFRL1 modulation of FGFR1 signaling 2255 27006 53834 8074 8817 2249 2248 2247 200734 161742 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 95%199992 trans-Golgi Network Vesicle Budding 10618 9698 4952 6456 7164 7163 5286 27131 26258 4074 9026 6810 1777 2799 10053 2647 8907 9179 8905 130340 1174 162 1785 164 408 1212 2495 8546 8729 2512 1362 2804 3312 8773 5878 375 8673 81567 6845 3482 9146 1522 388552 55330 27243 2580 10717 8906 9685 1176 6643 6844 54885 152503 84062 351 23431 23557 25977 286451 8301 9829 1213 1211 8775 7037 51429 134829 64746 157807 6272 11154 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME DATABASE ID RELEASE 95%2173793 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer 4904 5045 3065 1875 1874 5054 9612 905 9611 4221 4609 892 8812 5494 5933 7323 6233 7316 51592 54778 6498 22938 23439 6497 7321 4087 4088 7027 4089 7050 142 64750 4092 7029 1025 25937 904 6667 1030 2033 1024 7311 7314 5594 60436 5595 1278 3726 8239 23327 BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME%R-HSA-9026403.2 Biosynthesis of DPAn-3-derived 13-series resolvins 240 CALCINEURIN ACTIVATES NFAT%REACTOME DATABASE ID RELEASE 95%2025928 Calcineurin activates NFAT 4772 5534 5478 808 4773 4775 2280 5530 5532 GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME%R-HSA-5610785.2 GLI3 is processed to GLI3R by the proteasome 5706 5707 5708 5709 5700 5566 5701 5567 5702 5568 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 2737 11047 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 9861 8454 6233 5687 5688 9978 5689 2932 7316 1452 6500 10213 51684 8945 SARS-COV-1-MEDIATED EFFECTS ON PROGRAMMED CELL DEATH%REACTOME%R-HSA-9692913.2 SARS-CoV-1-mediated effects on programmed cell death 598 DEFECTIVE C1GALT1C1 CAUSES TNPS%REACTOME%R-HSA-5083632.4 Defective C1GALT1C1 causes TNPS 727897 29071 10071 94025 143662 140453 4588 118430 4589 283463 56913 394263 4582 4583 4584 4585 4586 200958 56667 NEGATIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME%R-HSA-9764725.1 Negative Regulation of CDH1 Gene Transcription 474382 2146 7088 3065 54145 23028 6935 5928 387893 5931 6591 3066 116092 94234 6929 23512 7750 348262 10009 8726 6938 54737 7291 1488 1487 8970 8331 8337 128312 8334 8335 5315 6597 8370 55766 8968 7490 8341 5594 8342 60436 5595 8347 7764 8348 117581 94239 8345 3013 9839 8340 23411 8338 255626 3021 653604 3018 6615 3017 85236 3014 8349 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%R-HSA-451308.4 Activation of Ca-permeable Kainate Receptor 1739 2900 83988 808 2899 2898 2897 1742 1741 2901 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 95%69580 p53-Dependent G1 S DNA damage checkpoint 1029 1017 1026 7157 9861 6233 25946 7316 11200 10213 64326 4194 4193 5706 5707 5708 5709 5700 5701 5702 898 5704 5705 5682 5683 9134 5684 1027 5685 5686 5717 5718 472 5719 11047 5713 5714 5690 5691 5692 5693 5694 57060 7311 7979 5695 7314 51230 5687 5688 5689 890 8900 DEFECTIVE DPAGT1 CAUSES CDG-1J, CMSTA2%REACTOME DATABASE ID RELEASE 95%4549356 Defective DPAGT1 causes CDG-1j, CMSTA2 1798 MATURATION OF SPIKE PROTEIN%REACTOME%R-HSA-9683686.4 Maturation of spike protein 7841 4245 23193 821 5589 RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME%R-HSA-6807505.4 RNA polymerase II transcribes snRNA genes 6908 905 6880 6882 6884 129685 6878 8812 6877 5451 6621 6619 7702 6618 10302 6617 5440 5441 1022 51585 6829 2963 2962 5434 5435 5436 5437 5438 5439 8178 22916 5430 51593 4686 5431 5432 5433 65123 6827 57508 80789 26173 55726 1025 5452 55756 64859 2961 26512 2960 23248 2959 904 6667 2958 25896 80237 2957 79035 79664 29101 22936 81556 55656 79871 23379 54973 92105 51808 55174 57117 55197 84524 58490 BETA DEFENSINS%REACTOME DATABASE ID RELEASE 95%1461957 Beta defensins 117285 1235 245936 245937 140850 245938 1673 245939 1672 245927 613210 245928 245929 613211 81623 245930 245932 245934 503841 641517 644414 613209 400830 504180 729230 245940 7097 7096 55894 100133267 140881 245913 503618 503614 245911 REGULATION OF INSULIN SECRETION%REACTOME%R-HSA-422356.6 Regulation of insulin secretion 114 2864 783 55970 5906 3745 5566 5567 3747 11069 5568 10411 54331 2767 3710 775 59345 773 2641 2769 9495 777 6804 2782 784 2776 10681 948 2778 2771 5578 2770 3708 3709 8826 4082 2740 6616 1131 2793 2792 5573 5575 2791 5576 5577 2790 6861 26251 2788 3630 6844 10768 2787 2786 3790 2785 6513 2784 6514 2783 5330 51764 5331 150 23236 152 9630 94235 2182 2181 6833 776 3767 6812 111 112 9254 DEFECTIVE ABCC9 CAUSES CMD10, ATFB12 AND CANTU SYNDROME%REACTOME%R-HSA-5678420.4 Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome 10060 3767 ATF6B (ATF6-BETA) ACTIVATES CHAPERONES%REACTOME%R-HSA-8874177.2 ATF6B (ATF6-beta) activates chaperones 8720 3309 1388 51360 INTERFERON GAMMA SIGNALING%REACTOME%R-HSA-877300.9 Interferon gamma signaling 4904 7706 2633 8651 3459 3460 5894 3383 3662 3107 3106 5371 3105 4938 5770 567 4940 8638 7412 7341 3661 3134 3133 8554 115361 2635 163351 115362 6737 2634 5580 4939 960 3665 815 816 3660 817 818 3717 3659 3716 3135 81603 55223 3123 3122 3120 3664 3119 3118 10612 3117 3115 55128 3113 117854 23321 4092 2209 51127 5724 10379 3127 7726 3126 85363 3125 10475 3394 6672 5781 4261 9830 23650 10107 10346 5777 10437 4281 79097 9021 11074 53840 3663 5594 80128 5595 80263 23087 3458 388646 4684 4502 ATP-DEPENDENT CHROMATIN REMODELERS%REACTOME%R-HSA-9932444.2 ATP-dependent chromatin remodelers 23506 65980 29998 55274 60 26039 8289 55193 6760 53335 64919 6595 6597 6599 57492 6598 29117 9274 9275 5977 6601 51412 8193 6603 6602 6605 196528 6604 605 8110 86 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%947581 Molybdenum cofactor biosynthesis 27304 10243 4338 55034 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME%R-HSA-381119.4 Unfolded Protein Response (UPR) 5611 6347 8720 84447 8894 3309 9695 1054 1051 84699 440 1965 6464 467 468 1968 1649 22872 7184 3576 2137 10525 2135 2931 27230 9451 11340 8570 23404 54512 118 5526 100137049 5393 23016 51726 37 5073 51010 167227 51013 2673 7094 118460 811 9820 22894 10130 56915 3068 55062 10954 10488 58477 6745 90993 9114 148327 10113 10897 4000 9797 7466 4189 153222 116138 9570 4800 6818 81501 4801 1388 7709 51360 4802 56005 10106 2081 55033 1663 9709 1200 64764 2134 22926 6734 64061 11015 55738 30827 1639 3484 DEFECTIVE FACTOR XII CAUSES HEREDITARY ANGIOEDEMA%REACTOME DATABASE ID RELEASE 95%9657688 Defective factor XII causes hereditary angioedema 2147 2161 3818 MRNA 3'-END PROCESSING%REACTOME DATABASE ID RELEASE 95%72187 mRNA 3'-end processing 4904 10914 10915 10236 11325 55749 6434 10921 10250 11338 29894 27316 4116 3183 6430 79869 5930 6432 6431 1660 22794 8175 23524 1655 6427 6426 9939 6429 10212 6428 8189 27336 1665 84991 3181 3188 65109 3187 3185 3184 55660 2521 3192 3191 3190 5499 9295 10569 83443 7307 51639 3178 9984 81608 57187 10898 84324 23283 10772 84321 9877 55339 64852 1479 26097 1478 1477 7919 10992 9879 8563 8683 11051 9775 55110 5725 10523 9785 10291 10978 199746 53981 84248 6233 58517 10181 8106 51692 7316 57794 5500 51213 10189 5440 4670 5441 64895 51585 5511 2963 5514 2962 22826 22827 5434 5435 5436 5437 5438 8241 5439 5093 5094 22916 5430 51593 4686 5431 23350 5432 79228 5433 10285 9584 6632 6631 10929 84844 51362 6625 6627 6626 6629 7311 135295 6628 7314 220988 10262 10946 23450 23451 6634 6633 6636 6635 6638 84271 6637 22803 80145 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 95%176409 APC C:Cdc20 mediated degradation of mitotic proteins 9861 6233 7316 10213 51529 7321 5706 8881 64682 5707 25906 5708 11065 8697 5709 7324 10393 29945 27338 119504 5700 5701 29882 891 5702 246184 983 996 5704 51434 5705 51433 5682 5683 5684 4751 5685 5686 5717 9184 5718 5719 991 11047 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 5687 5688 5689 4085 890 8900 9232 701 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%R-HSA-500657.3 Presynaptic function of Kainate receptors 2782 2788 2787 2786 55970 2785 2784 5330 2783 5331 51764 10681 23236 54331 59345 94235 2793 2792 2791 2899 2790 ZYGOTIC GENOME ACTIVATION (ZGA)%REACTOME DATABASE ID RELEASE 95%9819196 Zygotic genome activation (ZGA) 503835 2033 342900 390245 503627 55211 100033411 79670 284355 23318 7004 151871 1387 10413 100288687 7157 201516 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME%R-HSA-71291.10 Amino acid and derivative metabolism 435 1373 10166 5009 57407 383 7166 92259 2653 123688 51166 55526 89874 10157 3028 2639 1428 15 121278 438 6230 8942 6210 6231 11112 6234 51151 6235 6191 10247 2197 6193 6192 6194 51065 120103 140032 6205 6227 8564 275 6204 23498 6207 6229 6206 6228 6209 6208 6188 6520 6187 23446 6223 6201 6189 8140 6222 6203 125061 6224 38 6202 443 6218 2346 6539 6217 3921 339983 10003 374569 51074 130013 4329 6999 1610 5053 5409 85007 8528 7054 1644 9673 1621 9061 9060 169355 5827 54363 64902 586 2058 587 440 223 8424 56267 55217 51268 112817 6470 2731 9380 4948 3620 50506 7252 53905 4967 405753 9861 51061 6233 7173 1734 4552 1733 4947 389434 51582 79814 90527 6528 6303 51686 1735 6723 4946 262 6611 113451 4953 6175 10213 8604 4507 5706 5707 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 501 55349 29958 11047 1757 5713 5714 58510 5690 8659 5691 5625 5692 83884 384 5693 5694 7311 5695 857 5687 196743 2805 189 5688 5689 10165 64087 56922 1743 23743 58478 635 84245 55256 1081 7157 36 27034 6152 6155 6154 6157 9349 6156 6159 6158 23521 51121 11224 6164 7263 4548 200916 23408 6166 25828 6122 23474 6165 58472 6124 339896 6168 100131187 6123 51380 1468 6167 6169 1036 6125 6821 116832 4357 25873 84890 6160 6161 1892 140801 4736 6130 6133 9045 6232 6132 6176 6135 6134 6137 6136 6171 6170 6173 6128 6129 6142 6141 6144 6143 6146 6147 6181 6139 1728 6138 1158 6535 6534 2593 1152 1160 2628 6538 548596 259307 5860 5092 7299 80150 1638 7306 3081 6898 3242 2184 57515 10955 256987 113675 619189 26227 5723 10993 347735 144193 29968 65263 57571 63826 131669 57494 29920 7296 3067 11185 3034 2746 138199 27165 191 118672 10841 284716 51520 2744 875 883 1615 2752 5831 22928 3376 2954 4942 51091 2806 7965 2747 9521 51540 9255 6301 1491 27232 60678 5859 4141 4143 3176 152926 79048 26275 5917 549 3735 3712 4837 594 7979 2326 10295 1629 1738 593 2875 162417 445 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME DATABASE ID RELEASE 95%606279 Deposition of new CENPA-containing nucleosomes at the centromere 378708 474382 54145 79172 5928 91687 79682 80152 2491 5931 64946 387103 8467 55839 54069 8607 11339 51773 4869 55320 55355 8970 1060 8331 8337 128312 55166 8334 201254 8335 1058 79019 8370 55766 8341 8342 8347 8348 94239 8345 3013 23421 8340 57082 8338 255626 64105 401541 3018 3017 85236 3014 8349 THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME DATABASE ID RELEASE 95%2187335 The retinoid cycle in cones (daylight vision) 5949 611 6017 5956 2652 9249 158835 MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE%REACTOME DATABASE ID RELEASE 95%9854311 Maturation of TCA enzymes and regulation of TCA cycle 50 3418 6389 81689 54949 38 751071 23410 57001 6391 644096 6390 6392 135154 57128 122961 2395 1431 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME%R-HSA-450302.5 activated TAK1 mediates p38 MAPK activation 8517 10392 8767 3656 257397 9261 5600 3654 6885 23118 7335 10454 7334 7867 5606 64127 1432 7189 5608 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 95%75876 Synthesis of very long-chain fatty acyl-CoAs 9524 79071 60481 64834 401494 23205 23305 79993 253017 201562 51144 11000 54898 197322 51703 2180 6785 3293 2182 81616 2181 51495 83401 9200 DUAL INCISION IN GG-NER%REACTOME%R-HSA-5696400.3 Dual Incision in GG-NER 2071 2966 2965 2068 142 10714 2968 5424 8451 2967 5425 5981 57804 404672 2073 2072 5982 56655 5983 9557 5426 5427 51426 10038 2067 1642 54107 7311 7507 5111 7314 1643 6233 9978 6117 7316 5984 5985 6119 6118 RESPONSE OF EIF2AK4 (GCN2) TO AMINO ACID DEFICIENCY%REACTOME%R-HSA-9633012.4 Response of EIF2AK4 (GCN2) to amino acid deficiency 6152 6155 6154 6157 9349 6156 6159 6158 23521 51121 11224 6164 200916 6166 6122 6165 6124 6168 6123 6167 6169 6125 116832 25873 6160 6161 140801 4736 6130 6133 9045 6230 6232 6132 6210 6176 6231 6135 6234 6134 6235 6137 6191 6136 2197 6193 6171 6192 6170 6194 6173 6128 51065 6129 140032 6142 6205 6227 6141 6144 6204 6143 6207 6229 6146 6147 6206 6228 6181 6139 6138 6209 6208 6188 6187 6223 6201 6189 1386 6222 6203 6224 6202 6218 6217 3921 57761 8894 1054 1051 440 1965 467 468 1968 1649 6233 440275 55364 6175 10985 7311 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%R-HSA-3238698.3 WNT ligand biogenesis and trafficking 51699 9559 55737 79971 50999 7483 89780 51384 7484 7480 64840 7481 7471 81029 54361 7473 7479 7478 8724 7472 7475 7477 7474 7476 7482 80326 MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME DATABASE ID RELEASE 95%8949215 Mitochondrial calcium ion transport 3954 90550 91689 6687 9512 10939 8165 23203 55486 55013 79568 221154 6547 11331 30968 10730 7417 10367 7416 286097 7419 80024 5245 VISUAL PHOTOTRANSDUCTION%REACTOME%R-HSA-2187338.3 Visual phototransduction 335 375790 336 337 6121 3339 3949 64220 345 9227 6383 221914 5950 5959 6017 145226 9672 5956 5947 10082 6385 2652 50700 3292 158835 2262 344 6382 2239 2782 7804 4036 348 2719 1109 2817 808 338 5949 6010 6295 7276 5578 6011 3000 2986 1259 1258 5957 9397 131890 121214 5475 4035 2342 9187 29967 2779 10988 83875 23173 388531 1645 2339 79823 9626 5948 2979 26020 2978 54884 57016 53630 10170 5406 55937 9249 1208 8608 51109 8644 157506 151056 2792 8630 5145 285440 24 5158 5148 611 4647 338328 4836 5588 4023 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII CAMKK CAMKIV CASCASDE%REACTOME%R-HSA-442729.5 CREB1 phosphorylation through the activation of CaMKII CaMKK CaMKIV cascasde 3838 10645 84254 814 808 816 818 ACYL CHAIN REMODELLING OF PS%REACTOME%R-HSA-1482801.5 Acyl chain remodelling of PS 22925 114882 123745 5321 154141 10162 255189 64600 51365 254531 8399 114884 26279 11145 100137049 30814 5322 81579 283748 5320 5319 114879 AGMATINE BIOSYNTHESIS%REACTOME%R-HSA-351143.3 Agmatine biosynthesis 79814 113451 GRB2 EVENTS IN EGFR SIGNALING%REACTOME%R-HSA-179812.4 GRB2 events in EGFR signaling 255324 2069 1950 1956 374 1839 6654 4893 7039 685 3265 DEFECTIVE CYP21A2 CAUSES AH3%REACTOME%R-HSA-5579021.4 Defective CYP21A2 causes AH3 1589 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME DATABASE ID RELEASE 95%450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 8517 10392 5599 8767 3656 257397 3654 6885 23118 7335 5609 10454 6416 5601 7334 5602 64127 7189 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 95%157579 Telomere Maintenance 474382 54145 55135 1017 7015 2237 10856 100134934 8607 5537 5440 55505 5441 54433 23649 55651 5422 79991 5557 5558 54921 5434 5435 23243 5436 5437 5438 10714 5439 5424 5425 5981 57804 5430 3978 80119 1616 5431 7486 5432 5982 55164 5433 1736 546 5983 55291 63922 8970 8331 8337 80169 128312 8334 8335 79075 51750 8370 55766 8341 5111 8342 8347 8290 8348 94239 8345 26277 3013 25913 8340 7013 641 65057 1763 7014 8338 6117 255626 5984 54386 5985 890 6119 3021 8900 3018 6118 3017 85236 3014 8349 FORMATION OF THE POLYBROMO-BAF (PBAF) COMPLEX%REACTOME%R-HSA-9933939.1 Formation of the polybromo-BAF (pBAF) complex 6597 6599 6598 29117 55274 60 9274 9275 6601 6603 6602 55193 196528 6605 6604 605 6595 86 TGFBR1 KD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3656532 TGFBR1 KD Mutants in Cancer 7046 4087 4088 7048 7040 THE NLRP1 INFLAMMASOME%REACTOME%R-HSA-844455.2 The NLRP1 inflammasome 22861 596 598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 95%416993 Trafficking of GluR2-containing AMPA receptors 80852 5579 2892 2891 2893 2890 7102 23426 4905 5578 9463 160 5582 DEFECTIVE FACTOR IX CAUSES THROMBOPHILIA%REACTOME%R-HSA-9672383.2 Defective factor IX causes thrombophilia 2158 2157 2159 RSK ACTIVATION%REACTOME%R-HSA-444257.5 RSK activation 27330 6197 6196 5594 5595 6195 5170 RHOD GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013405 RHOD GTPase cycle 4001 9217 51479 87 29984 9590 5295 5296 123720 158747 1627 9497 26092 832 1729 79180 7444 2909 9743 57584 27145 392 9341 394 101059918 7879 57144 3998 55240 81839 23092 144402 10424 5361 5364 2010 23344 29127 857 8987 3930 84681 55789 56924 120 4162 7112 94134 80728 81624 23592 55114 CLEC7A INFLAMMASOME PATHWAY%REACTOME DATABASE ID RELEASE 95%5660668 CLEC7A inflammasome pathway 29108 4790 3553 5970 10892 841 INHIBITION OF HOST MRNA PROCESSING AND RNA SILENCING%REACTOME DATABASE ID RELEASE 95%168315 Inhibition of Host mRNA Processing and RNA Silencing 8106 10898 OADH COMPLEX SYNTHESIZES GLUTARYL-COA FROM 2-OA%REACTOME DATABASE ID RELEASE 95%9858328 OADH complex synthesizes glutaryl-CoA from 2-OA 55526 1743 1738 SARS-COV-1 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9679514.4 SARS-CoV-1 Genome Replication and Transcription 85437 5925 7428 1655 MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME%R-HSA-163316.4 Mitochondrial transcription termination 7978 REGULATION OF CDH11 FUNCTION%REACTOME DATABASE ID RELEASE 95%9762292 Regulation of CDH11 function 1495 64403 80332 1006 1500 51129 3728 1009 1499 8728 HDL CLEARANCE%REACTOME%R-HSA-8964011.2 HDL clearance 81693 335 3069 8029 MITOTIC PROPHASE%REACTOME%R-HSA-68875.7 Mitotic Prophase 4926 26003 4001 10051 10592 54892 29781 23310 79648 348995 9883 6396 129401 9688 57122 23225 4927 23165 55746 55706 23636 9631 7175 9972 2801 11097 23279 8086 23511 53371 8480 79023 79902 10762 8815 5903 5925 8970 8331 8337 128312 8334 8335 8370 55766 8968 8341 5594 8342 8347 8290 8348 94239 8345 3013 8340 8338 255626 3021 653604 3018 3017 9663 85236 3014 8349 474382 54145 64900 23175 5519 387893 5515 5516 5518 5578 8021 891 983 5347 10776 81876 5579 5861 5862 2010 255919 84930 2029 55844 64689 6418 9133 140609 8615 91754 7443 10783 8548 23592 221496 OTC MAIN CHAIN VARIANTS CAUSE OTC DEFICIENCY%REACTOME%R-HSA-9956553.1 OTC main chain variants cause OTC deficiency 5009 TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-HSA-6791312.6 TP53 Regulates Transcription of Cell Cycle Genes 9125 7832 1017 10498 1026 995 144455 1874 25904 581 23019 4850 1647 55571 7157 4848 4849 3276 5933 5934 246175 6790 25946 79733 2810 57472 7027 4869 1263 891 5325 898 983 10769 9134 85456 1027 7029 1869 29883 2033 1820 57060 9337 5111 55835 890 8900 28984 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME%R-HSA-68689.6 CDC6 association with the ORC:origin complex 990 84515 5000 5001 23595 23594 4998 4999 PROTEIN UBIQUITINATION%REACTOME%R-HSA-8852135.4 Protein ubiquitination 5828 56254 3105 55284 7320 997 10670 7874 7317 7319 7323 6233 7322 3093 7332 7316 118424 7327 7326 7328 7347 7321 54926 65264 11065 92912 10477 7324 5195 27338 5192 8078 5193 5194 7415 7334 8970 7336 55236 90268 29089 79139 92305 7311 6596 23168 8341 5111 7314 9781 8342 56852 8347 79577 8348 51322 5591 8345 80349 123169 8340 51255 9646 257218 55829 255626 9810 220441 54623 8915 3018 3017 85236 8239 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME DATABASE ID RELEASE 95%8939245 RUNX1 regulates transcription of genes involved in BCR signaling 640 861 1998 865 5079 1997 HDL ASSEMBLY%REACTOME%R-HSA-8963896.2 HDL assembly 2 29801 335 5566 19 5567 5568 SIGNALING BY FGFR2%REACTOME DATABASE ID RELEASE 95%5654738 Signaling by FGFR2 2252 2251 8074 2249 2248 2247 2246 8823 5295 143282 5290 5725 2255 23543 54845 5515 9982 5516 5518 6233 80004 7073 7072 83888 7316 5440 4670 5441 3187 3185 673 5335 2963 2962 867 5434 5435 5436 5437 5438 5439 22916 10817 5430 4686 5431 5432 5433 10253 8569 5781 4893 27006 2549 7311 7314 5594 5595 10818 3178 8817 26281 6654 2254 3265 FLT3 SIGNALING%REACTOME DATABASE ID RELEASE 95%9607240 FLT3 Signaling 867 6776 9402 2887 207 1445 2323 5795 2322 1027 5295 2534 6850 5781 3055 4893 3932 5290 27 9846 7311 7314 10018 6233 10019 8835 9306 6503 84174 208 10000 7316 2309 6654 6777 3265 IMATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669917.2 Imatinib-resistant KIT mutants 3815 LIGAND-RECEPTOR INTERACTIONS%REACTOME DATABASE ID RELEASE 95%5632681 Ligand-receptor interactions 50937 91653 6469 50846 2619 3549 5727 64399 RHOT2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013419 RHOT2 GTPase cycle 22906 5910 66008 80179 89941 9927 55669 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME%R-HSA-193807.3 Synthesis of bile acids and bile salts via 27-hydroxycholesterol 1646 1645 6718 1109 1582 1581 9971 9420 8648 6256 10499 8644 80270 1593 LEISHMANIA PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 95%9664417 Leishmania phagocytosis 10006 60 10810 2268 9844 4644 5879 4627 63916 71 7454 7456 10109 1398 1793 10552 10093 10092 10095 4067 10094 10097 695 10096 147179 25 4690 10458 51517 55845 4650 644150 917 2534 4651 8976 8936 6850 3055 4620 10787 4641 2214 10152 998 5594 5595 10451 7410 3071 10163 5747 7525 7409 23191 26999 T(4;14) TRANSLOCATIONS OF FGFR3%REACTOME%R-HSA-2033515.2 t(4;14) translocations of FGFR3 2261 BIOSYNTHESIS OF LIPOXINS (LX)%REACTOME%R-HSA-2142700.7 Biosynthesis of Lipoxins (LX) 22949 239 240 3248 4056 241 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME DATABASE ID RELEASE 95%1236978 Cross-presentation of soluble exogenous antigens (endosomes) 5706 5707 5708 5709 4360 5696 5700 5701 5702 5704 5705 5682 5683 5684 5685 2209 5686 5721 5717 5718 5719 5698 5720 5699 11047 5713 5714 5690 5691 5692 5693 5694 7979 5695 9861 5687 9902 5688 5689 50489 10213 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 95%380259 Loss of Nlp from mitotic centrosomes 10383 10382 1781 1778 7846 5566 9793 7277 5518 9738 9662 7840 11064 22994 22995 7283 10733 80321 203068 55722 1454 1453 3320 55125 9814 11190 115106 79441 95681 1069 54801 983 10142 9702 10540 8655 5347 5108 11116 4751 55142 22897 54930 5116 79959 80184 93323 5577 23354 22981 8481 80254 121441 55755 23332 7532 10806 10121 7531 55559 8636 22919 11258 5048 84131 4957 55835 54820 NGF PROCESSING%REACTOME DATABASE ID RELEASE 95%167060 NGF processing 5045 5046 5125 4803 THE ACTIVATION OF ARYLSULFATASES%REACTOME DATABASE ID RELEASE 95%1663150 The activation of arylsulfatases 347527 285362 79642 25870 340075 410 412 414 415 416 411 22901 153642 DEFECTIVE GCLC CAUSES HAGGSD%REACTOME DATABASE ID RELEASE 95%5578999 Defective GCLC causes HAGGSD 2730 2729 PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME%R-HSA-6811558.5 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling 90865 9173 940 7189 930 118788 941 942 5880 8394 8395 50852 8870 1950 1956 2099 5156 5781 27006 8503 3630 2549 5159 8660 9542 10718 145957 5594 5595 3815 10818 3643 8817 26281 7409 1839 391 9965 2254 2252 51135 2251 4233 8074 2249 2248 4615 2247 2246 2323 2322 152831 5879 8823 5295 5296 2264 5519 5290 5291 2255 9846 3667 5305 5515 5516 5518 23396 3084 3654 5525 5526 5527 5528 146850 5529 5294 6714 2100 23533 79837 2064 6801 207 8396 374 2534 3932 3082 5293 4915 4909 627 7039 685 5155 255324 2069 4916 4908 PI-3K CASCADE:FGFR1%REACTOME%R-HSA-5654689.4 PI-3K cascade:FGFR1 27006 2255 2251 8074 2549 2249 2248 2247 10818 2246 5295 26281 5781 5290 2254 DISEASE%REACTOME%R-HSA-1643685.19 Disease 553 554 10058 6566 91445 6048 9152 682 6557 91319 6559 9843 5244 10956 55788 28234 81031 6569 1836 6584 10568 6578 283652 55763 8729 1545 113612 2263 11041 9215 29954 7334 10585 55624 1605 4968 10018 9469 38 10451 7410 10294 7409 2288 1639 2542 10728 572 3459 3460 26229 3551 8878 4615 5599 5879 2237 1594 1591 340665 120227 56603 7341 7329 7322 9978 6921 6923 7428 5440 8732 5441 4331 8731 1022 2071 2966 6829 2965 833 2963 1937 2962 2068 5434 5435 5436 5437 5438 5439 2968 2967 404672 5430 5431 5432 5433 902 2793 2792 2791 1460 2790 1459 2788 1457 2787 2786 2785 2784 2783 51764 94235 55970 60 399687 80304 55109 161742 27044 4763 57670 57448 22808 54331 399473 11221 8805 56829 53335 59345 10342 9715 200734 4170 471 23164 3092 8546 7157 64840 6238 57085 2782 11044 11052 54845 9444 2804 9451 9208 1852 10681 1850 10827 8036 50616 348995 50507 9883 26127 6396 8087 129401 9688 291 292 57122 293 23225 3836 4927 3843 3159 23165 11168 55746 55706 23636 9631 7175 9972 11097 23279 8086 23511 53371 8480 79023 79902 10762 8815 5903 6232 8655 1855 998 1857 1856 51143 51181 1147 1781 1780 1778 57551 5905 1783 5501 3688 5519 71 140735 5515 5516 5518 92579 5525 5526 5527 5528 5529 3791 4791 23189 2120 51411 6801 2803 11081 4969 3938 6476 8178 22916 4166 25920 4686 51224 4958 6924 5549 7936 6827 6749 9150 6917 1025 51497 7469 11198 904 28514 729238 182 3955 8454 9148 54492 142678 26508 388585 6500 57534 51284 3718 3554 5336 30011 4916 6773 2926 4908 3615 3614 29760 51185 1312 973 5894 23186 5906 974 5908 3454 10280 5566 5133 23476 5567 59272 25855 5568 10800 5926 10362 51317 4627 22872 7318 7317 10533 84313 51028 11267 9871 5119 10951 9632 7335 10427 2335 114609 7448 811 6230 6210 6231 6234 2209 6235 6191 22863 2197 6193 6192 6194 55236 51065 140032 6205 6227 6204 6207 6229 6206 6228 6271 1915 6209 6208 6188 6187 6223 6201 6189 6222 6203 6224 6202 3178 57674 6218 6217 3921 4851 4853 11285 4854 126792 4855 1839 2646 2645 2923 3326 3107 3106 23352 57521 3134 3133 558 1977 64223 2280 84335 2475 7249 9246 5062 3135 10811 1535 4360 10458 7879 55845 10802 10484 8936 10787 4008 10152 10333 9039 124056 7172 8065 613 857 79876 3071 51191 10163 80824 23191 2260 2589 7113 6733 27035 10006 55914 7046 7048 51293 7040 6948 4001 55048 89853 1104 51534 9525 137492 27183 51271 51160 155382 93343 7251 79720 5902 51510 8459 8460 115004 4296 5648 2547 7454 7520 7456 3981 7518 113189 3795 6152 6155 6154 6157 9349 6156 6159 6158 23521 147179 51121 11224 6164 200916 6166 6122 6165 6124 8826 6168 6123 6167 6169 6125 116832 25873 6160 4158 6161 140801 4736 4650 6130 6133 9045 644150 6132 6176 6135 6134 9532 6137 6136 6171 6170 6173 6128 8976 6129 6142 6141 6144 6143 6146 6147 6181 6139 6138 611 23168 79577 80349 123169 3690 9646 3674 54623 8829 5604 55733 6469 5605 50846 51135 7100 4793 4060 375790 81793 2331 3656 257397 23118 176 3339 5609 6416 5601 4131 3442 3441 25820 1107 3440 54797 5610 10332 55090 3452 3066 3451 80306 9759 3449 3448 23512 3447 4939 3446 3445 23097 3444 3443 6837 8312 219541 2932 23389 324 3456 1452 55588 139285 9636 9412 1524 400569 30835 5230 2678 2687 2730 26873 2729 2023 2937 229 374 4780 598 1387 6667 5777 814 4915 4909 627 7039 685 255324 2069 2002 10000 2309 5747 54463 7474 8324 3725 10060 6833 3767 111 112 113 114 115 107 108 27436 109 196883 11045 4072 1583 5025 2268 4843 3710 5593 1593 6916 1589 5027 1588 1585 64174 2778 3708 3709 2232 126410 2230 6440 9146 11151 3837 26276 5868 22937 54716 378884 8908 7957 340024 2998 2632 5507 6505 9685 6507 9056 153201 2592 6520 11254 11136 6519 1849 1848 84061 11282 7841 55750 29801 25921 253832 51201 55741 1650 11320 51125 4247 51304 100128731 4249 6185 10461 7991 4124 4245 6184 25834 23193 58505 201595 2530 79844 821 11253 5589 51114 746 1603 3703 8767 57506 9868 8658 8678 4193 7353 4087 4088 4089 5728 114548 89122 4792 10392 317772 23586 5293 1800 85235 4303 9420 64426 7706 993 10254 84282 6881 6885 8027 57599 408 80351 409 1080 7187 7186 7189 221613 8850 92815 10454 8969 9817 440689 64127 112812 8737 51616 1892 64135 2099 7415 2648 8517 51639 53938 8896 81608 10898 1500 23283 51645 22987 9899 6843 24148 55696 9900 55339 597 1479 1478 1477 3662 85437 23020 85313 10992 9879 9410 4644 8683 10084 11051 9775 5725 10523 9785 10291 10978 199746 53981 9416 8449 10181 8106 51692 7852 57794 1234 5500 10189 4670 22938 51340 51585 22826 22827 10284 10283 8241 5093 5094 51593 23350 10286 10285 988 9343 6632 57461 84844 56259 51362 6627 6629 6628 220988 10262 10946 23450 23451 54883 6634 57105 56949 6633 6636 5546 6635 6638 6637 10907 9360 4904 10914 10594 10236 11325 55749 27238 10921 11338 29894 6430 6432 6431 1660 8175 23524 1655 10450 6427 6426 9076 6429 57703 6428 8189 51729 5356 27339 1665 84991 10465 3181 3188 3187 3185 3184 2521 9716 51503 2683 10421 3192 285755 3191 11100 64225 3190 689 5499 440400 1993 9295 4666 91937 550 83443 7301 7307 4061 51234 22924 23443 10949 23169 10999 7355 9197 55315 3815 6908 2308 3654 2100 81857 1020 653509 6439 834 3676 10628 1024 4790 79109 23327 2146 10013 10014 10025 6772 5443 892 3276 10001 3280 8726 29079 55534 5469 145173 57188 2591 143662 79695 10417 118430 10418 54457 170689 171019 54437 9510 9037 4582 5199 4583 7058 4584 4585 4586 9862 200958 157869 727897 29071 9507 140766 80070 9508 9509 10071 94025 84441 339366 221981 79875 81794 140453 55901 4588 4589 81792 283463 9719 56999 56913 394263 11173 11096 11095 11174 80731 170690 54507 170692 92949 170691 6456 6455 2060 6457 54815 5052 1938 130589 7001 84447 84246 51564 23493 9443 9441 8325 9442 9440 3799 51586 23462 2584 2582 9439 10109 10155 10552 10093 10092 10095 2811 10094 2810 10097 10096 9219 22906 7296 9477 3831 7057 112950 8148 7291 51517 83737 7295 95 1514 152926 26275 549 3712 7082 3726 9282 5611 84661 721 11091 5928 5929 905 3516 5931 930 712 9070 716 79885 719 722 725 1108 23479 83933 4869 5970 6616 6857 3549 10769 4437 5782 10971 5978 3569 51311 5053 57459 3839 2633 402569 3840 3841 4436 23601 6872 2548 6874 6873 2799 995 51003 6880 6883 6882 6884 2212 945 55615 6875 29108 6878 8812 6877 6879 2588 55869 5869 6648 5878 2064 4318 6993 138474 8851 3164 7532 7531 7533 3043 684 11314 7525 5236 5371 138050 9734 9968 9969 129685 4292 356 5395 29959 7276 25 253260 142 53615 1654 2908 2992 9794 10046 54658 54657 90390 83860 3845 8085 2538 8315 5245 3717 673 5551 2244 29851 2266 7414 3587 51530 8844 10256 6776 54518 22866 4140 7450 5037 2243 7094 1445 369 283455 10817 917 10479 285195 2534 4651 6850 4620 3055 4641 3932 2677 2214 2159 2621 2147 2158 5627 594 10295 1629 1738 593 1213 1211 51128 81693 5034 8029 160 161 163 335 1175 1173 3069 5292 115361 2634 9641 3665 2161 2160 2812 3818 2815 2814 9530 8945 11093 57504 9112 4040 22943 4860 4041 89780 3251 27121 79412 100 83999 353 27123 5573 5575 5576 5577 5613 24 7855 8322 4210 10910 4907 8323 953 957 9051 3480 80853 64220 9227 5950 222236 145226 5956 5947 326625 10525 3040 163351 5901 2984 112755 79849 79872 127833 4552 6575 203068 10142 25777 11116 4751 2694 27249 25974 63982 203859 1185 476 57101 477 478 53822 53826 53828 338440 480 481 482 483 486 55107 118788 80143 2885 55129 1439 50636 1438 6777 196527 57719 5348 5349 1488 1487 121601 4691 1052 5159 9542 10718 145957 55247 79661 4913 10313 79760 91662 27072 84818 6607 23339 9908 10146 79833 11218 23765 6441 11311 4153 25929 5479 7555 10207 57617 64601 948 23367 26762 54960 55823 11123 8487 7284 65082 9111 79685 92359 50628 26007 3605 112744 8974 54431 283208 51726 5033 10527 191 4143 8819 1789 4128 1788 1786 51742 22934 143 2931 56965 83666 84875 79668 54956 54625 1398 2328 8772 79643 51652 197259 929 79792 91782 3552 2339 708 92421 3553 837 841 11035 3002 27243 55666 128866 10134 10015 148022 29082 25978 3146 8717 4000 23643 7099 3606 1687 4836 102 54567 5663 23385 55851 5664 83464 51107 9061 9060 2131 6448 4669 6383 79651 221914 136 9332 2781 9672 10082 6385 2262 6382 2239 2719 2817 7750 6528 4067 695 146850 5294 23533 6175 2261 2997 375 3716 5478 6888 7297 54894 3586 1982 8672 4478 317649 5495 238 3838 10768 4594 166785 64087 5096 686 5091 56922 3141 5095 9789 23478 60559 28972 90701 2305 8496 6868 3714 5959 6017 56667 2697 941 942 6711 5880 6199 50852 4548 4690 5781 4893 7535 8503 27006 2549 51606 8660 5594 5595 30849 10818 208 8817 26281 9965 391 26999 5289 6654 2254 3265 2252 2251 10945 8074 2249 2248 2247 2246 2323 10810 2322 152831 8823 5295 7170 5296 7171 6464 2264 5290 1523 5291 63916 5170 2255 9846 9648 54106 3667 81622 7098 21 808 9382 3084 1794 1793 815 6714 816 817 818 51529 7321 8881 64682 25906 11065 8697 7324 10393 29945 27338 119504 29882 9321 891 246184 1584 996 51434 51433 7486 5982 5883 5884 5983 116028 3364 472 10635 672 675 84126 83990 22856 3082 144715 83695 5810 7516 10111 5932 7979 4361 351 7156 5890 9156 5892 4683 11073 580 5155 10524 641 1763 545 6117 5984 5985 2157 6119 79728 5888 6118 928 80010 5889 6249 162417 445 435 1373 10166 5009 57407 383 4057 6279 3309 710 6280 7097 7096 1191 920 1901 23649 5422 1511 831 2801 5557 5558 84290 823 824 826 5156 2961 2960 2959 2958 2957 2194 31 4233 3065 25942 1029 595 1017 994 1026 1499 5824 6934 1051 3417 4609 6804 4343 192669 999 26523 192670 27161 57690 9861 6233 3312 7316 7514 3162 10213 7534 8021 5706 5707 5708 5709 1981 207 5700 5701 5702 7529 5704 5705 5682 5683 5684 5685 5686 80273 5717 5718 5719 1994 1432 11047 215 5713 5714 5690 5691 6844 5692 5693 5694 7311 5695 7314 26986 54464 3304 10965 5687 5688 5689 842 5002 79644 718 5045 7431 9475 8452 10250 9844 27316 10053 8907 8905 6093 130340 3183 1174 162 55690 79869 164 3105 940 567 926 2652 64398 3661 340061 29110 81030 1462 2990 3373 81631 7405 3074 5987 3073 63827 1634 1586 3425 411 2720 3423 633 1464 1463 10675 9397 2342 11140 3320 1950 5335 867 1956 7027 1021 1019 894 896 1871 898 1870 51343 6502 3978 1616 2956 9134 1028 1027 546 7029 1869 5925 8970 6421 8331 8337 128312 8334 8335 2033 1974 8370 1973 55766 8968 8341 8342 8347 8348 94239 8345 3013 3570 8340 8338 255626 6774 3021 6732 653604 3018 3017 85236 3014 6886 8349 474382 54145 861 23028 6907 79718 64241 64240 9612 8841 9611 19 346562 2874 56052 440138 79053 10610 6483 2771 22845 2770 6482 6484 6487 5476 10020 2773 3098 79087 9187 6480 256435 2673 8813 27090 85365 551 8818 29929 4351 10195 55343 1798 79796 27248 10559 79139 26154 8647 91869 51009 6005 116150 6521 6400 9990 5373 368 6513 60482 26503 6514 116085 5826 199857 11160 8671 54344 6531 6530 79868 9526 142680 123041 79947 1356 4758 6524 6523 10599 246213 5172 55630 1244 56606 4891 30061 10613 1811 552 INTERLEUKIN-35 SIGNALLING%REACTOME%R-HSA-8984722.5 Interleukin-35 Signalling 3716 6774 3572 6772 821 7297 6775 3595 9466 10148 3717 3592 TRANSPORT OF ORGANIC ANIONS%REACTOME DATABASE ID RELEASE 95%879518 Transport of organic anions 53919 6578 10599 6579 353189 6567 551 11309 28231 28234 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME DATABASE ID RELEASE 95%2454202 Fc epsilon receptor (FCERI) signaling 10235 6885 10125 3710 7462 7189 7294 2206 2205 7335 10454 3708 3709 8945 5335 115727 5970 4775 7334 4893 4772 5534 8517 5594 5595 5530 10451 5532 7410 8915 7409 1147 6654 3265 4214 3551 5599 257397 2207 23118 5879 5609 6416 5601 5295 5296 5602 997 10892 5290 84433 5291 5170 9846 808 9861 6233 7322 4067 7316 695 7006 10213 7321 5062 5706 5707 5708 5709 9402 5700 4773 5701 5702 3937 5704 5705 5682 23291 5683 5684 5685 5686 5717 5718 5719 3702 2534 6850 11047 5713 5714 5690 5691 5692 10768 5693 4792 5694 7311 7979 5695 7314 4790 8454 5687 5688 2353 5689 5058 6500 5588 3725 5336 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME DATABASE ID RELEASE 95%2173795 Downregulation of SMAD2 3:SMAD4 transcriptional activity 3065 4087 4088 4089 7050 142 64750 4092 9612 25937 9611 5494 7311 7314 5594 60436 5595 7323 6233 7316 51592 54778 6498 22938 23439 8239 6497 7321 23327 RUNX3 REGULATES P14-ARF%REACTOME%R-HSA-8951936.2 RUNX3 regulates p14-ARF 2033 861 865 7040 595 864 9759 3845 6046 CD163 MEDIATING AN ANTI-INFLAMMATORY RESPONSE%REACTOME DATABASE ID RELEASE 95%9662834 CD163 mediating an anti-inflammatory response 5045 3586 6868 79651 9332 3569 4627 1432 10769 RND1 GTPASE CYCLE%REACTOME%R-HSA-9696273.2 RND1 GTPase cycle 10963 5783 1969 57449 55704 9462 667 27316 10817 9928 1832 9352 22800 81839 5295 5296 9231 8502 5361 56667 224 1362 11180 22852 94240 91544 857 2886 10818 55789 57498 27289 11075 7037 9528 2909 2319 23592 57579 394 222584 57216 INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME DATABASE ID RELEASE 95%9670095 Inhibition of DNA recombination at telomere 474382 54145 5434 5435 5436 5437 5438 5439 5430 1616 5431 5432 5433 546 8970 8331 8337 128312 8334 8335 8370 55766 8341 8342 8347 8290 8348 94239 8345 26277 3013 25913 8340 7013 65057 7014 8338 255626 54386 3021 3018 5440 3017 85236 5441 3014 8349 RHOBTB3 ATPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9706019 RHOBTB3 ATPase cycle 10489 22836 10226 7428 51209 8452 9146 898 9367 STRAND-ASYNCHRONOUS MITOCHONDRIAL DNA REPLICATION%REACTOME%R-HSA-9913635.2 Strand-asynchronous mitochondrial DNA replication 92667 9941 6742 7156 56652 246243 11232 5428 5442 HEREDITARY FRUCTOSE INTOLERANCE%REACTOME%R-HSA-5657560.5 Hereditary fructose intolerance 229 COLLAGEN FORMATION%REACTOME%R-HSA-1474290.5 Collagen formation 649 7837 79709 5351 5352 8985 1297 7093 7092 1284 50509 1282 1286 1281 26577 1285 256076 169044 5118 1280 81578 255631 57642 5479 1310 340267 7373 136227 131873 91522 1296 1295 1294 1293 1292 1291 1290 1305 1303 1302 1301 1289 8974 1300 3914 1288 283208 1287 85301 5033 1308 3918 1307 84570 1306 3909 4318 1520 10536 1514 55214 64175 1515 23127 9313 140766 9508 9509 977 5339 4314 3691 1278 1277 80781 84171 4322 4015 3655 4016 10491 871 4017 4316 1508 84695 5034 1299 1298 LANOSTEROL BIOSYNTHESIS%REACTOME%R-HSA-9969896.1 Lanosterol biosynthesis 10654 9453 39 4047 403313 3422 4598 6713 4597 91734 2224 2222 3157 TRANSCRIPTION OF THE HIV GENOME%REACTOME DATABASE ID RELEASE 95%167172 Transcription of the HIV genome 83860 6872 6874 6873 6881 6908 905 6880 6883 6882 6884 129685 6875 6878 8812 6877 6879 6921 6923 5440 8732 5441 4331 8731 1022 2071 2966 6829 2965 2963 8148 2962 2068 5434 5435 51616 5436 5437 5438 5439 2968 8178 2967 22916 404672 5430 25920 4686 5431 138474 5432 54457 51224 5433 6924 7936 902 6827 6749 9150 6917 1025 51497 2961 7469 11198 2960 2959 904 2958 2957 NEF MEDIATED CD8 DOWN-REGULATION%REACTOME%R-HSA-182218.5 Nef Mediated CD8 Down-regulation 163 1175 1173 51606 926 160 161 TRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 95%6787450 tRNA modification in the mitochondrion 84705 64172 54802 55687 3028 54931 9692 25821 79693 55006 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 95%446728 Cell junction organization 5928 1785 9069 23562 9080 53842 137075 51208 5010 24146 9073 5931 9071 9076 149461 9074 9075 26285 1366 1365 1364 49861 84552 6251 7016 10686 2316 5829 29780 3611 55742 54751 55679 7408 3987 2318 3914 288 1308 3918 3909 5584 29954 10585 283 977 221935 5339 54549 1508 7841 7088 3065 1650 100128731 87 1499 6185 6184 9459 23193 58505 821 5589 746 1603 3703 4609 4343 192669 23112 27327 999 26523 6591 4613 192670 116092 27161 7020 3170 94234 57690 23396 93986 9861 6929 55810 6233 687 79872 7750 348262 10009 7316 10213 9743 4193 5706 6938 5707 5708 5709 10979 5700 5701 5702 1520 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 1460 11047 5713 5315 1459 5714 5690 5691 1457 5692 5693 5694 7311 5695 7314 3691 5687 5688 5817 5819 5689 3655 23411 9789 23478 60559 5045 2146 28972 5046 90701 283106 9159 64398 81607 27085 5818 57863 1013 23705 1010 1008 1007 1003 8726 1005 1004 1001 1002 1016 1015 1012 253559 50855 25945 667 1488 1487 7122 50848 5925 8970 3728 8331 56288 8337 128312 8334 9314 8335 6597 8370 55766 54971 8968 8341 8342 5594 8347 5595 28513 8348 2294 7764 117581 94239 80149 8345 56978 3013 9839 8728 8340 6663 1495 64403 8338 27319 80332 255626 1006 1500 3224 3021 3609 653604 6615 3018 1009 3017 85236 3014 8349 474382 54145 2060 1000 23028 6935 8289 3688 387893 84612 3066 10207 23512 92359 6714 7414 54737 7291 10399 1514 6667 7490 7979 60436 11171 26508 51129 REGULATION OF EXPRESSION OF SLITS AND ROBOS%REACTOME%R-HSA-9010553.2 Regulation of expression of SLITs and ROBOs 10921 4440 4116 56956 22794 89884 9939 6152 6155 6154 6585 6157 3199 9349 6156 23053 6159 6158 23521 51121 11224 6164 65109 200916 6166 1287 6122 6165 6124 6168 6123 6167 6169 6125 116832 25873 9355 6160 8022 9353 6161 140801 6091 4736 6092 6130 6133 9045 6230 6232 6132 6210 6176 6231 6135 6234 6134 6235 6137 6191 6136 2197 6193 6171 6192 6170 6194 6173 6128 51065 6129 140032 6142 6205 6227 6141 6144 6204 6143 6207 1605 6229 6146 6147 6206 6228 6181 6139 6138 6209 6208 6188 6187 6223 6201 6189 6222 6203 6224 6202 6218 6217 3921 9775 55110 8453 9861 6233 9978 7316 6921 6923 10213 6175 2107 5706 23708 5707 2935 5708 5709 1981 5700 5701 5702 22916 5704 23032 5705 4686 5682 26019 5683 5684 5685 5686 65110 5717 5718 5719 11047 5713 5714 5690 5691 5692 5693 8861 5694 7311 7979 5695 7314 26986 5687 5688 5689 3670 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME DATABASE ID RELEASE 95%2029482 Regulation of actin dynamics for phagocytic cup formation 10006 60 3326 10810 9844 4644 5879 3984 4627 2212 63916 71 4771 7454 7456 10109 1398 1793 10552 10093 10092 10095 10094 10097 695 10096 147179 25 4690 3320 10458 51517 55845 4650 644150 1072 917 2209 4651 8976 8936 6850 4620 10787 4641 2214 10152 998 5594 5595 10451 7410 3071 5058 10163 5747 7409 23191 26999 UNCOATING OF THE HIV VIRION%REACTOME DATABASE ID RELEASE 95%162585 Uncoating of the HIV Virion 5478 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME DATABASE ID RELEASE 95%1834949 Cytosolic sensors of pathogen-associated DNA 4793 28512 3551 4615 1499 28511 51082 1660 115004 22954 9447 3661 84265 340061 29110 55703 147945 81844 11128 51728 7098 23220 81030 27297 11277 2547 661 6737 7520 170506 51428 9533 9208 10623 3428 6233 197358 171568 55718 10622 10621 3665 7316 4791 5440 5441 8737 5434 5435 5437 5970 11035 1387 148022 2033 8517 4792 7311 6778 4361 7314 4790 5591 1147 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%R-HSA-168643.3 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 3551 3326 3656 257397 6885 23118 22861 7189 64170 9447 5027 29108 58484 6300 5603 8767 3654 7335 10454 3162 4791 64127 5608 1540 329 83737 5970 837 7295 841 114548 330 7334 834 596 835 1432 598 14 7128 10628 8517 10392 351 4790 4210 10910 9051 5600 842 24145 1147 BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME DATABASE ID RELEASE 95%9027604 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives 5743 240 GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 95%8856688 Golgi-to-ER retrograde transport 11127 56894 10959 5049 8729 5321 8398 378 832 26286 8655 9183 84364 1062 1315 9493 10112 9554 5048 26958 9585 8774 8775 51143 23046 55860 24137 51164 11015 55738 830 26153 55605 10671 636 1639 23299 93661 22920 55850 84516 10945 1781 63908 51014 1780 55614 146909 1778 81930 84643 55582 23423 3796 23303 372 1783 4905 381 5050 9371 221458 662 547 140735 11004 55083 3798 3799 5870 2590 51560 25782 113220 3797 3832 10972 3833 3834 6836 3835 64837 90990 22931 9276 89953 285643 147700 375 11316 3831 23095 10749 60561 22818 22930 1314 10540 124602 54732 56992 51226 53407 64147 829 22820 377 51594 11014 81876 5861 29127 10121 11258 2589 SIGNALING BY JUXTAMEMBRANE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9669935.2 Signaling by juxtamembrane domain KIT mutants 3815 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3311021 SMAD4 MH2 Domain Mutants in Cancer 4087 4088 4089 FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC%REACTOME%R-HSA-389960.4 Formation of tubulin folding intermediates by CCT TriC 10383 10382 112714 7846 84790 84617 908 113457 6950 7203 10574 7280 347733 10576 7277 7278 22948 79861 81027 10693 10376 10694 10575 80086 51807 10381 TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME%R-HSA-9013973.6 TICAM1-dependent activation of IRF3 IRF7 3661 29110 7098 7311 7314 6233 10133 10010 9641 3665 7316 7187 148022 ABORTIVE ELONGATION OF HIV-1 TRANSCRIPT IN THE ABSENCE OF TAT%REACTOME DATABASE ID RELEASE 95%167242 Abortive elongation of HIV-1 transcript in the absence of Tat 6829 2963 2962 5434 5435 5436 5437 5438 5439 22916 5430 25920 5431 4686 5432 5433 7936 6827 9150 5440 51497 7469 5441 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME DATABASE ID RELEASE 95%174411 Polymerase switching on the C-strand of the telomere 23649 5422 79991 5557 5558 54921 10714 5424 5425 5981 57804 5982 5983 63922 80169 79075 5111 26277 25913 7013 65057 7014 54386 100134934 5984 5985 SUPPRESSION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 95%9635465 Suppression of apoptosis 57674 5987 1511 2931 5594 6421 5595 PHOSPHORYLATED BMAL1:CLOCK (ARNTL:CLOCK) ACTIVATES EXPRESSION OF CORE CLOCK GENES%REACTOME DATABASE ID RELEASE 95%9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes 5936 6097 1628 8553 4862 9572 1408 6095 1407 5187 85457 150094 8864 8863 23373 406 9575 4297 7942 1387 SENSORY PERCEPTION OF TASTE%REACTOME%R-HSA-9717189.3 Sensory perception of taste 259289 50840 259287 259286 259285 6340 2914 259293 80835 259292 80834 133060 259290 5726 259296 6337 259295 6339 3710 6338 2911 346562 6324 2782 6330 6335 2784 5330 51764 83756 6326 54795 6328 6327 50831 50833 50832 50834 50837 50836 255022 29850 50839 119395 50838 3759 54429 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%R-HSA-2660825.3 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 28514 4851 182 6868 3714 102 54567 CS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%2022870 CS-GAG biosynthesis 337876 55501 50515 55790 54480 166012 79586 55454 56548 1462 9469 10090 63827 1634 51363 633 1464 1463 10675 22856 RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME%R-HSA-8876198.4 RAB GEFs exchange GTP for GDP on RABs 2665 10890 81846 51399 5873 6305 22878 22879 221960 79890 117177 11031 80006 2664 5874 5870 51762 23682 51560 25782 10260 6764 9909 57679 84315 160518 5869 163259 22931 126432 51209 79090 26130 3257 27342 5878 79958 9367 201627 338382 27095 1121 163486 201475 7109 1122 6399 207 11021 7879 5864 9827 57706 126003 5872 22930 23258 79961 51693 122553 116442 5868 60684 23011 83696 10981 4218 54734 5866 58485 84079 22898 54453 55667 27147 51622 259173 89781 9610 81876 5861 414918 51112 7531 51552 8408 208 10000 57589 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 95%159231 Transport of Mature mRNA Derived from an Intronless Transcript 23636 55339 9631 7175 9972 11097 23279 8086 23511 10482 53371 8480 79023 79902 10762 5903 22916 29894 4686 1977 53981 8189 348995 9883 6396 129401 81608 9688 51692 10898 57122 23225 10189 4927 23165 55746 8021 55706 TRAIL SIGNALING%REACTOME DATABASE ID RELEASE 95%75158 TRAIL signaling 8772 8797 843 8837 8795 8743 841 8793 INTERLEUKIN-6 SIGNALING%REACTOME%R-HSA-1059683.5 Interleukin-6 signaling 3716 867 6774 3572 9021 6772 7297 3569 5781 3717 3570 RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME%R-HSA-6811440.2 Retrograde transport at the Trans-Golgi-Network 10618 84316 400 63908 57511 8674 4074 8677 8675 339122 51542 84342 91949 7110 10226 4905 10244 9648 23647 22836 22796 79571 5870 9382 51560 51209 25839 9712 9341 90196 10228 9367 122830 83548 2803 60560 10466 9827 3482 6293 2800 738 55275 8774 8775 57589 10139 143187 60592 SIGNALING BY NODAL%REACTOME%R-HSA-1181150.3 Signaling by NODAL 130399 5045 91 5046 92 93 4087 8928 4088 10589 4089 5594 5595 4838 10637 55997 6998 199699 9350 2657 2309 6997 7044 RESPONSE TO METAL IONS%REACTOME%R-HSA-5660526.6 Response to metal ions 1465 6620 4520 4493 4494 4495 4496 4499 4489 4501 4502 4504 84560 4490 DEFECTIVE SLC1A3 CAUSES EPISODIC ATAXIA 6 (EA6)%REACTOME%R-HSA-5619062.4 Defective SLC1A3 causes episodic ataxia 6 (EA6) 6507 INTERCONVERSION OF POLYAMINES%REACTOME%R-HSA-351200.3 Interconversion of polyamines 6303 196743 PTEN LOSS OF FUNCTION IN CANCER%REACTOME%R-HSA-5674404.3 PTEN Loss of Function in Cancer 5728 PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 95%5651801 PCNA-Dependent Long Patch Base Excision Repair 54107 5111 10714 5424 5425 5981 57804 3978 5982 56655 2237 6117 5984 5983 5985 5423 6119 6118 5426 5427 328 CHOLESTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%191273 Cholesterol biosynthesis 1718 403313 51478 64801 4597 6307 50814 2224 6720 2222 3157 1595 6721 1717 10654 6309 9453 39 4047 3422 4598 6713 7108 3930 10682 91734 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-352230.6 Amino acid transport across the plasma membrane 54716 23428 92745 6533 206358 84889 6509 120103 55089 117247 340024 10991 9056 9057 153201 6520 8501 6541 123096 81539 8140 23657 55117 56301 11254 6539 11136 6519 124935 54407 6510 GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1306955.5 GRB7 events in ERBB2 signaling 2064 9542 2886 3084 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190239 FGFR3 ligand binding and activation 8823 8074 8817 2249 26281 2247 2246 2591 2254 INTERFERON ALPHA BETA SIGNALING%REACTOME DATABASE ID RELEASE 95%909733 Interferon alpha beta signaling 51447 8651 3662 3454 3107 3106 6041 6772 3105 4938 5770 4940 8638 1958 3442 3441 3661 3440 3134 5610 3133 3452 3451 3449 2634 3448 3447 6233 4939 3446 3445 3444 8519 3443 3665 7316 3456 9636 3836 3660 3659 3716 3135 10410 5696 91543 7297 3430 3664 3669 3429 3837 3437 3434 3433 4600 10379 6059 4599 11274 3394 5781 10581 5777 25939 24138 7311 9021 7314 3663 54739 103 2537 684 6773 EVENTS ASSOCIATED WITH PHAGOCYTOLYTIC ACTIVITY OF PMN CELLS%REACTOME%R-HSA-8941413.2 Events associated with phagocytolytic activity of PMN cells 4025 4353 INDUCTION OF CELL-CELL FUSION%REACTOME%R-HSA-9733458.3 Induction of Cell-Cell Fusion 5045 196527 57719 55107 59272 338440 63982 121601 203859 55129 50636 7113 57101 DEFECTIVE AVP DOES NOT BIND AVPR2 AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-9036092.3 Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) 554 551 RESISTANCE OF ERBB2 KD MUTANTS TO AFATINIB%REACTOME DATABASE ID RELEASE 95%9665249 Resistance of ERBB2 KD mutants to afatinib 11140 3320 2064 55914 THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514856.3 The phototransduction cascade 2342 9187 2779 10988 23173 388531 2339 79823 9626 2979 2978 2792 5145 2782 5158 5148 808 6010 6295 6011 5578 4836 3000 2986 5588 1259 1258 5957 9397 131890 5475 BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME%R-HSA-1307965.3 betaKlotho-mediated ligand binding 152831 9965 2264 DEGRADATION OF DVL%REACTOME%R-HSA-4641258.3 Degradation of DVL 5706 5707 5708 5709 5700 8452 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 1855 11047 5713 5714 5690 5691 5692 1857 5693 1856 5694 7311 7979 5695 7314 9861 6233 5687 5688 9978 5689 51339 59349 23072 7316 10213 MELANIN BIOSYNTHESIS%REACTOME%R-HSA-5662702.6 Melanin biosynthesis 51151 4948 7299 7306 1638 SORAFENIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702624 sorafenib-resistant FLT3 mutants 2322 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%R-HSA-204998.3 Cell death signalling via NRAGE, NRIF and NADE 83464 29 8874 51107 64857 572 57449 4803 389337 445328 2245 23263 50650 8878 26574 221472 5599 9639 10672 10276 55701 5879 9459 9138 4168 27018 27237 7074 6655 11214 5924 7189 6233 7316 835 7204 9500 55160 23365 9181 7311 128272 57580 7314 4804 7531 10018 26230 121512 1894 10451 23421 7410 84904 100271715 26084 23370 25791 89846 9826 54848 9828 7409 836 23229 22899 5663 50649 6654 8997 23385 55851 6453 5664 7984 ACYL CHAIN REMODELLING OF PC%REACTOME%R-HSA-1482788.5 Acyl chain remodelling of PC 10162 129642 64600 26279 30814 8605 50640 81579 151056 22925 79887 123745 5321 79888 255189 54947 8398 254531 8399 255043 11145 100137049 5322 283748 5320 5319 50487 MPS IX - NATOWICZ SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206280.5 MPS IX - Natowicz syndrome (Hyaluronan metabolism) 3373 RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION%REACTOME%R-HSA-8940973.2 RUNX2 regulates osteoblast differentiation 632 221044 25925 865 10013 5594 5595 23462 121340 23314 3280 1277 4094 367 6714 7525 5925 8841 25 25937 2737 23493 10413 CONJUGATION OF CARBOXYLIC ACIDS%REACTOME%R-HSA-159424.4 Conjugation of carboxylic acids 54988 389396 116285 348158 10249 123876 341392 219970 92292 NEUREXINS AND NEUROLIGINS%REACTOME%R-HSA-6794361.6 Neurexins and neuroligins 57669 58512 10611 91683 341359 57555 85358 9454 9455 347731 347730 2036 9456 22829 22941 50944 26037 26045 57596 2037 2035 9229 9369 54413 8573 6804 55327 9378 9379 320 64130 143425 8825 321 127833 1742 1741 1740 80059 2906 2905 2904 28988 2903 2902 6857 2911 2915 23136 22871 9066 57502 81858 6812 9546 22839 PI-3K CASCADE:FGFR3%REACTOME%R-HSA-5654710.4 PI-3K cascade:FGFR3 8074 2549 2249 2247 10818 2246 8823 8817 5295 26281 5781 5290 2254 RHO GTPASES ACTIVATE IQGAPS%REACTOME DATABASE ID RELEASE 95%5626467 RHO GTPases activate IQGAPs 8826 1495 998 5879 999 808 4221 1499 6249 128239 10788 EPH-EPHRIN SIGNALING%REACTOME%R-HSA-2682334.3 EPH-Ephrin signaling 163 83464 8874 51107 1969 9475 60 1759 2045 2044 2043 5879 2042 6093 4628 1175 2041 1173 79784 4629 8218 6383 7074 4313 3984 10627 3985 2046 103910 4637 4627 1212 71 64283 10398 10109 10552 10093 10092 10095 4067 10094 10097 2904 10096 2902 1943 1942 2051 2050 5062 2049 1946 2048 6386 1945 2047 1949 1948 1944 1947 4318 5063 284656 1072 2534 8976 5921 998 10451 7410 1213 1211 25791 5058 8440 5747 28964 7525 387 102 5663 160 8997 23385 161 55851 6453 285220 5664 3265 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 95%418457 cGMP effects 27094 27345 8654 3778 3779 5136 5138 10846 3708 10335 5152 10242 5153 50940 5593 MATRIGLYCAN BIOSYNTHESIS ON DAG1%REACTOME DATABASE ID RELEASE 95%9939291 Matriglycan biosynthesis on DAG1 9486 11041 9215 113829 729920 120071 2218 10329 79147 10559 55624 1605 ALK MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 95%9700645 ALK mutants bind TKIs 1213 57448 6801 27436 53335 5495 9451 4869 5573 238 3092 2335 SIGNALING BY NTRK2 (TRKB)%REACTOME DATABASE ID RELEASE 95%9006115 Signaling by NTRK2 (TRKB) 5335 2549 4915 4909 1020 627 10818 1795 10817 5879 2904 7074 5295 8851 6714 5781 6654 4893 5290 3265 4908 SLC25A15 VARIANTS CAUSE HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINEMIA SYNDROME%REACTOME%R-HSA-9956508.1 SLC25A15 variants cause hyperornithinemia-hyperammonemia-homocitrullinemia syndrome 10166 ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME%R-HSA-9027276.3 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 2056 4067 2549 5294 5295 8660 5293 23533 5290 5291 3717 2057 ERYTHROPOIETIN ACTIVATES RAS%REACTOME%R-HSA-9027284.2 Erythropoietin activates RAS 2056 4067 2889 8660 1399 7409 6464 6654 4893 3717 2057 3265 GLYCOGEN STORAGE DISEASES%REACTOME DATABASE ID RELEASE 95%3229121 Glycogen storage diseases 5507 7311 7314 2548 92579 6233 378884 7316 8908 7957 2992 2542 2538 2998 2997 2632 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 95%70326 Glucose metabolism 5566 5567 5568 26330 5519 5105 5515 5516 2203 5518 8789 92579 54020 57818 5106 348995 9883 6396 129401 9688 5528 57122 7167 23225 5223 5224 4927 230 80201 23165 2538 283209 2821 8021 55746 2027 55706 2026 3098 23636 5214 9631 7175 5230 5232 9972 3099 11097 132789 23279 2597 8086 3101 23511 387712 53371 5210 8480 5211 79023 5213 79902 2023 10762 10007 5903 226 83440 229 669 5207 5208 5209 5091 2646 2542 2645 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME DATABASE ID RELEASE 95%1234158 Regulation of gene expression by Hypoxia-inducible Factor 2056 3091 2033 405 25994 7422 10370 768 1387 2034 ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-HSA-73930.5 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway 5423 328 RAF ACTIVATION%REACTOME%R-HSA-5673000.4 RAF activation 673 8844 5894 4140 7529 369 22808 5501 5519 4893 4296 5515 5516 808 5518 8036 5525 5526 815 5527 5528 5500 5529 6714 5604 816 5605 817 8315 818 5245 3265 3717 ARACHIDONATE METABOLISM%REACTOME DATABASE ID RELEASE 95%2142753 Arachidonate metabolism 10728 5445 5446 1582 1580 2053 1573 4056 6916 57834 158833 5321 64174 9261 5730 284541 158584 5740 80142 4051 126410 1558 1579 1557 1545 2678 1544 113612 4048 1543 2687 8529 5742 1559 5743 240 241 242 246 2876 247 11283 8644 22949 239 2879 59344 145482 27306 376497 9536 1800 873 2166 3248 2877 5444 127281 4363 SMAC, XIAP-REGULATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 95%111469 SMAC, XIAP-regulated apoptotic response 331 840 842 317 836 54205 56616 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 95%2559580 Oxidative Stress Induced Senescence 474382 2146 54145 1029 5599 5928 5609 6416 5601 7867 5602 5606 8535 7157 6045 4343 192669 23112 27327 648 5931 26523 6015 23466 192670 1912 57690 1911 23512 6233 80012 57332 9261 84733 7316 3456 8726 4194 4193 5608 7027 1021 1019 7295 1871 1870 7029 1869 8970 8331 1432 8337 128312 8334 1030 8335 8370 1032 55766 1031 8968 23043 7311 23135 50488 8341 9448 7314 5594 8342 5595 8347 8348 94239 8345 2353 3013 4217 5600 8340 8338 255626 3021 653604 3725 3018 3017 85236 3014 8550 8349 SCAVENGING BY CLASS B RECEPTORS%REACTOME%R-HSA-3000471.6 Scavenging by Class B Receptors 3146 5052 335 6280 284297 922 338 6288 948 CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME DATABASE ID RELEASE 95%8955332 Carboxyterminal post-translational modifications of tubulin 10383 164395 260334 10382 112714 26140 23093 7846 84871 84790 123624 22846 84617 340351 113457 84276 79805 7280 347733 7278 150465 79841 25941 25809 79739 158135 81027 91978 284076 23287 23170 374969 10376 254173 347688 9654 60509 54839 10381 83887 DAP12 INTERACTIONS%REACTOME%R-HSA-2172127.3 DAP12 interactions 100049587 10326 5335 7305 9402 23601 3107 3937 3106 5879 5295 5296 124599 2534 567 284266 6850 54210 4893 3932 5290 100132285 5291 9436 54209 3133 342510 22914 3809 3810 3813 3822 3824 10451 7410 695 6654 5336 3265 DNA REPLICATION PRE-INITIATION%REACTOME%R-HSA-69002.4 DNA Replication Pre-Initiation 3836 23649 5422 5557 5558 3837 51343 56655 8970 8331 5426 8337 5427 128312 8334 8335 8370 55766 8968 54107 8341 8342 8347 8348 94239 8345 3013 8340 8338 255626 3021 653604 3018 3017 85236 3014 8349 474382 54145 8317 1017 8318 29935 10926 55388 23633 9861 6233 7316 10213 51529 7321 5706 8881 64682 5707 25906 5708 11065 5709 8697 7324 10393 29945 27338 119504 5700 5701 29882 5702 246184 996 5704 51434 5705 51433 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 4172 4173 4174 5687 4175 5688 4176 4171 5689 990 84515 51053 6117 5000 5001 6119 23595 6118 23594 81620 4998 4999 SCAVENGING BY CLASS H RECEPTORS%REACTOME%R-HSA-3000497.2 Scavenging by Class H Receptors 55576 6678 23166 338 ACROSOME REACTION AND SPERM:OOCYTE MEMBRANE BINDING%REACTOME%R-HSA-1300645.4 Acrosome Reaction and Sperm:Oocyte Membrane Binding 49 113177 100129669 284359 928 126123 DISEASES OF CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 95%9630747 Diseases of Cellular Senescence 1029 1021 1019 ABC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619084.7 ABC transporter disorders 10058 91445 6048 335 91319 5244 10956 55788 64241 64240 19 1080 21 9861 6233 7316 10213 5706 5707 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 7415 5717 5718 5719 27248 11047 79139 215 26154 5713 8647 5714 51009 5690 5691 5692 6400 5693 5694 368 7311 7979 5695 7314 5826 11160 5687 5688 5689 1244 10060 6833 10613 3767 MYOCLONIC EPILEPSY OF LAFORA%REACTOME DATABASE ID RELEASE 95%3785653 Myoclonic epilepsy of Lafora 5507 378884 7316 7311 7314 7957 2992 6233 2997 THREONINE CATABOLISM%REACTOME DATABASE ID RELEASE 95%8849175 Threonine catabolism 10247 113675 10993 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69613.5 p53-Independent G1 S DNA Damage Checkpoint 993 9861 6233 9978 2932 7316 1452 11200 10213 8945 79858 1454 5706 5707 5708 5709 5700 1263 5701 5702 5704 5705 5682 23291 5683 5684 5685 5686 5717 5718 5719 1432 11047 1111 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 8454 5687 5688 5600 5689 6500 DEFECTIVE SLC22A5 CAUSES SYSTEMIC PRIMARY CARNITINE DEFICIENCY (CDSP)%REACTOME DATABASE ID RELEASE 95%5619053 Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP) 6584 ENDOSOMAL VACUOLAR PATHWAY%REACTOME DATABASE ID RELEASE 95%1236977 Endosomal Vacuolar pathway 3135 3134 3133 4012 1514 3105 3107 567 3106 1520 1515 GLI PROTEINS BIND PROMOTERS OF HH RESPONSIVE GENES TO PROMOTE TRANSCRIPTION%REACTOME%R-HSA-5635851.3 GLI proteins bind promoters of Hh responsive genes to promote transcription 2737 2736 2735 SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME DATABASE ID RELEASE 95%4085377 SUMOylation of SUMOylation proteins 23636 9631 7175 51588 9972 11097 23279 8086 23511 53371 8480 79023 79902 10762 5903 7341 10210 7329 348995 9883 6396 129401 6613 9688 57122 23225 4927 23165 55746 8021 55706 NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 95%5654727 Negative regulation of FGFR2 signaling 2252 673 2251 8074 867 2249 2248 2247 2246 8823 10253 8569 5781 27006 2255 5515 7311 5516 7314 5518 5594 5595 6233 10818 7316 8817 26281 2254 MPS IV - MORQUIO SYNDROME B (KERATIN METABOLISM)%REACTOME%R-HSA-2206308.5 MPS IV - Morquio syndrome B (Keratin metabolism) 2720 CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 95%2559583 Cellular Senescence 2146 4001 3024 29855 25842 8091 7290 23523 57634 5928 3009 3008 3007 3006 3005 3397 7157 5931 8726 3159 3552 7027 1021 1019 5970 1871 898 1870 51343 9134 1027 7029 1869 5925 8970 8331 8337 128312 8334 8335 8370 55766 8968 23135 8341 5594 8342 5595 8347 3569 8290 8348 94239 8345 26277 3013 25913 8340 7013 65057 7014 8338 255626 54386 6774 3021 5598 653604 3018 3017 85236 3014 8550 8349 474382 54145 1029 1017 1026 5599 5609 79813 6416 1051 5601 10919 7867 5602 5606 8535 4343 6045 192669 3576 23112 648 27327 6015 26523 23466 192670 1912 57690 1911 23512 6233 80012 57332 84733 9261 7316 3456 4194 51529 7321 4193 5608 8881 64682 25906 11065 8697 7324 10393 29945 27338 119504 29882 7295 246184 996 51434 51433 27287 472 1432 6667 1030 2114 2113 1032 3490 10111 1031 23043 7311 50488 6197 4361 9448 7314 6196 4790 6195 4683 4217 2353 5600 2077 10524 890 8900 3725 GSD II%REACTOME%R-HSA-5357609.5 GSD II 2548 2992 SIGNALING BY FGFR4 IN DISEASE%REACTOME DATABASE ID RELEASE 95%5655291 Signaling by FGFR4 in disease 5335 2549 5295 2264 6654 10818 4893 5290 3265 NUCLEAR EVENTS MEDIATED BY NFE2L2%REACTOME%R-HSA-9759194.4 Nuclear events mediated by NFE2L2 8714 6347 1029 5052 8878 5563 3417 468 4609 9861 6233 9978 2932 7316 3162 9817 10213 4199 2539 8945 5706 7296 5707 5708 1950 5709 7086 2730 6888 5700 5701 5970 2729 7295 5702 5704 5705 5682 5683 5684 571 5685 5686 5717 374 5718 596 5719 4780 5154 598 140809 1387 11047 6667 7975 5713 10061 5714 2033 5690 5691 2938 5692 1728 2940 5693 5694 7311 7979 5695 7314 4790 84181 6649 8454 23657 5687 5688 5689 4851 4097 6500 5226 9429 4363 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 95%1660499 Synthesis of PIPs at the plasma membrane 4952 5286 8898 8821 55361 22874 55300 81846 9107 3631 4534 54477 5295 5296 84725 27124 3636 5290 5291 8871 5305 23396 8867 80230 3635 146850 8394 5294 23533 8395 79837 8897 375 5783 57664 51763 5867 66036 5728 59339 59338 5868 8396 5287 5288 8503 660 5293 8776 51552 55613 65977 64419 DIGESTION OF DIETARY CARBOHYDRATE%REACTOME%R-HSA-189085.4 Digestion of dietary carbohydrate 11181 1118 280 27159 278 279 8972 3938 6476 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 95%140877 Formation of Fibrin Clot (Clotting Cascade) 2244 2 2266 3053 708 5197 3827 7450 57126 2243 2152 462 5547 5196 710 5657 2159 2147 2158 2155 2153 5624 5627 7035 2165 2149 7056 2162 2161 2811 2160 5270 2812 2157 3818 5104 2815 2814 10544 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73856.6 RNA Polymerase II Transcription Termination 55339 10914 1479 26097 1478 7919 1477 10921 10250 11338 8563 29894 8683 11051 4116 9775 6430 7884 79869 6432 6431 55110 22794 9785 6427 6426 10978 9939 6429 25888 199746 53981 10212 84248 6428 8189 8106 51692 51213 10189 65109 51585 9295 10569 22916 4686 84967 79228 7307 134353 51362 6628 9984 6634 81608 57187 10898 6636 84324 23283 6635 84271 6637 84321 9877 80145 DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BARD1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9699150 Defective DNA double strand break response due to BARD1 loss of function 672 580 REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO%REACTOME%R-HSA-428542.5 Regulation of commissural axon pathfinding by SLIT and ROBO 6586 6585 6714 9353 6091 6092 1630 9423 4753 DEFECTIVE SLC6A5 CAUSES HYPEREKPLEXIA 3 (HKPX3)%REACTOME DATABASE ID RELEASE 95%5619089 Defective SLC6A5 causes hyperekplexia 3 (HKPX3) 9152 ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME%R-HSA-8937144.3 Aryl hydrocarbon receptor signalling 405 57491 10728 196 3326 9049 9915 STIMULI-SENSING CHANNELS%REACTOME%R-HSA-2672351.7 Stimuli-sensing channels 1179 150159 7439 5894 51802 6446 22802 219931 9635 338440 1193 2281 1188 10786 285175 65266 65268 65267 285335 144453 7220 10110 7442 7222 6717 7224 55107 7223 6263 7226 6262 7225 94015 59341 6261 79054 55283 23678 2040 26133 28962 54795 8989 55503 55515 40 4308 41 162514 255231 266675 57192 80036 56302 54831 51393 57113 55129 50636 29850 54822 9311 140803 161003 259232 7809 444 284525 196527 57719 10345 1831 6340 80727 57578 121601 53373 6337 6339 6338 11059 808 6233 7316 7311 7314 65125 63982 1187 203859 1186 1185 1184 1183 1182 1181 133308 1180 57101 23327 OXIDATIVE DEMETHYLATION OF DNA%REACTOME%R-HSA-5221030.6 Oxidative demethylation of DNA 6996 54790 80312 200424 ASS1 VARIANTS CAUSE CITRULLINEMIA%REACTOME DATABASE ID RELEASE 95%9956520 ASS1 variants cause citrullinemia 57407 445 DEFECTIVE SLCO1B3 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME%R-HSA-5619058.4 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) 28234 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 95%168256 Immune System 91445 6048 91319 10956 7334 7336 10987 11119 11118 696 103 56244 10018 7498 11120 10385 153579 10451 10384 7410 79908 55860 51164 4502 830 7409 10671 1639 93661 3306 3305 84516 8651 3459 3460 3551 8878 4615 5599 5879 6655 7341 7329 8453 7323 7322 2034 9978 3091 6921 6923 7428 5440 5441 5434 5435 5437 6950 1460 26272 1459 1457 26234 6468 10694 26190 26270 10383 55294 60 1823 10517 84261 4170 7157 26224 9451 54461 9208 8877 50616 348995 9883 6396 129401 2220 9688 1401 8547 10584 57122 23225 3836 4927 23165 55746 55706 23636 9631 7175 9972 11097 23279 8086 23511 53371 8480 79023 79902 10762 5903 8655 3848 1062 991 998 5493 51143 54014 387 1147 378708 51447 1781 1780 1778 81930 84643 3796 1783 3688 5519 332 84265 55703 51466 71 11128 140735 51728 5515 11004 27297 661 5516 5518 10623 171568 79980 1729 5525 55718 10622 5526 10621 5527 5528 5529 7422 4791 29126 3561 51411 4692 10538 3598 3597 6624 79923 149233 4985 51561 3566 3976 5008 8454 142678 6500 51284 3718 3554 5336 30011 6773 3615 3614 29760 121260 23108 6494 973 5894 5906 974 5908 3454 5909 5566 5133 23476 5567 11069 5568 10411 10235 10125 3984 759 4627 154881 7320 7325 8575 6477 131405 6895 22872 221687 7220 79654 51088 9616 90678 7318 7226 7317 56658 7319 10533 22888 3093 9870 9871 64167 9632 7335 150726 10425 64718 10427 118424 23295 55336 7327 7326 197131 9867 7328 2335 10422 54926 8673 65264 9520 114609 10193 7448 10075 93611 3911 127247 401036 115727 79791 29927 55585 57520 89910 811 5896 51665 5897 7337 51666 26091 55905 2209 63893 22863 142686 57531 142685 55236 51676 5720 142689 223082 91694 10293 9666 6271 1915 51320 80204 10616 57542 51444 11146 135892 55008 9554 6047 6049 23376 23014 57674 143279 25793 84231 11275 50489 9320 55819 64410 26253 90025 50856 10462 222235 84937 93978 140691 79132 54476 51465 54850 8887 54941 140456 140458 90933 140459 2923 90135 8771 128178 25897 8995 9690 146330 970 140460 1896 140461 10913 3326 3107 4049 10673 140462 939 3106 255488 8740 114088 8600 54620 8744 4982 23352 7293 868 51719 8916 7292 5562 115290 3604 60401 7704 5563 23495 55958 8139 943 5564 390594 944 5565 9966 127544 8718 55284 608 84961 28956 27246 997 8924 122769 55004 8925 8649 64320 51422 9354 3134 3133 1977 81559 55175 5571 84708 7174 64223 27252 55176 51130 642 2280 51132 55824 26046 9902 53632 2475 9903 6890 9246 4591 25847 6892 6891 8773 158506 92369 55182 5803 126433 26259 64219 23304 7064 9341 201456 5062 144699 3135 1536 899 84861 92912 1535 10477 4360 10458 5696 26268 55070 90293 7879 55845 84727 4688 92591 4689 26263 10802 1520 26267 10484 9235 53339 10489 285231 89890 4012 9820 26235 26118 79176 26232 8936 55521 5698 10787 5699 84085 27 4008 10152 10333 51725 9039 26249 25831 8065 84078 2889 55658 29127 140739 51619 9040 8987 148581 79876 79754 84541 9730 3071 154214 51191 151636 80176 5058 51752 10163 9604 136371 10324 23191 653361 10006 7040 4001 8808 27179 27177 22861 56300 26525 124599 284266 84639 115004 54210 7462 2495 100132285 9436 9447 7294 2206 7184 2205 2512 342510 81035 4025 78989 196051 5648 22914 3809 2547 7454 170506 7520 3810 7456 3813 2040 3822 8405 10331 3824 84513 80380 10788 64333 147179 8826 23526 5063 4650 644150 5337 6059 3728 8976 26191 5591 4684 3685 8915 5604 84166 6285 6288 92610 6283 51295 3693 51135 4214 7100 9684 4793 28512 57161 79671 3687 177 121457 81793 246330 28511 3656 257397 23118 1326 5609 466 80216 6416 5601 7867 5602 5606 3442 3441 25820 3440 5610 8554 3452 3451 3449 3448 23512 3447 4939 3446 3445 3444 3443 2932 3456 9636 5223 230 30835 2821 327 3101 5211 226 596 4780 4311 598 1387 151888 8764 5777 2353 2002 10000 22926 2309 5747 3725 9798 5023 2268 8792 4842 4055 8742 4843 3710 4050 115650 4846 51330 959 3636 80228 84876 5027 79888 338 5175 6786 3708 3709 5743 3837 5641 8904 114876 5598 51231 1849 1848 1846 1845 84061 1525 1650 120425 51125 4267 100128731 6185 7991 972 6184 23646 58505 201595 821 5589 746 1603 3703 6478 8767 57506 221 9868 8678 8895 4048 63891 4088 55593 240 9097 5728 246 64750 114548 4092 11274 5071 7128 89122 4792 10392 8560 23586 5293 51552 7706 11010 84282 6885 7187 7186 7189 79155 8398 2625 10454 9817 64127 80142 1540 8737 329 122618 57153 64135 330 7415 94103 8517 3609 634 3662 8563 6935 4644 5873 9775 1234 5094 5724 2358 9180 133396 200081 6809 27189 1489 58985 132014 6627 3574 3572 1271 1270 3575 3590 4314 3589 3588 85480 10148 64109 23529 163702 55540 29949 116379 53833 53832 55801 282617 282618 11009 282616 246778 9466 50604 9244 386653 4904 3603 1440 64806 301 1660 10450 199990 55120 2189 91442 80233 2175 2188 2187 57697 3181 2178 3185 59307 11213 2683 8514 201626 6041 4938 4940 8638 2308 10413 3654 4988 1493 5608 3683 4773 834 835 3676 10628 843 604 847 4790 3458 909 1278 56253 56654 5817 5819 89858 910 911 912 4068 3803 3804 3805 3806 79109 374383 925 10666 3802 285852 23547 23327 29121 10990 2146 4345 10871 10870 3811 3812 27181 353514 114836 117157 2213 946 3820 3821 340205 640 10219 146894 57823 10859 6515 11024 11027 135250 131450 6772 9437 5443 259197 79168 29992 2176 29990 10225 89790 4277 114132 51348 11126 11006 339390 100131439 9976 100507436 80329 79465 3904 79865 27036 146722 6614 196500 8519 8726 4718 81603 10410 2690 55223 2689 91543 3430 3664 3669 3429 5618 200845 10612 143662 3437 55128 118430 3433 10964 117854 23321 51127 10379 7726 4582 85363 5199 10475 4583 3394 25937 6672 4584 4261 4585 10581 4586 9830 23650 200958 6597 10107 10346 727897 10437 25939 4281 24138 79097 11074 53840 10071 54739 94025 80128 80263 23087 8784 388646 2537 140453 1442 4588 1510 4589 1519 8722 83547 283463 3112 3111 3902 394263 84676 3109 3108 6456 1938 11059 9761 7004 7003 7005 4771 3798 3799 10109 10552 10093 10092 10095 10094 2810 10097 10096 64837 51209 114907 89953 147700 3831 7291 51517 83737 7295 4257 1514 1513 1515 1471 9021 3958 3726 5611 84661 721 3977 11091 2519 1435 5928 5929 4312 4313 1399 3080 4179 1361 1380 10877 10878 730 731 5931 27202 732 930 733 975 712 735 713 81494 9070 714 715 716 717 719 3078 3075 1370 3426 1369 722 966 725 727 728 729 1604 23308 80331 5864 4869 5970 6616 5780 5782 5784 8809 54472 5778 8807 7850 58508 4215 3562 84867 3559 26095 3558 11141 1378 3557 3565 27178 10068 5771 3596 26469 25930 3569 1386 51311 10695 1508 3839 2633 402569 3840 3841 23601 22875 2548 2665 5300 10890 374395 10549 2799 201294 4973 5775 2207 1118 1116 2204 1476 80301 4208 932 5834 10875 5836 27180 3310 81619 2215 2212 945 2219 3684 55615 29108 2352 116844 387263 10857 114790 2588 6947 5870 124583 960 961 388698 2357 963 388697 2289 965 968 3689 6836 5869 54778 22931 3579 3577 976 978 6648 5878 6727 4680 83716 338339 55276 4317 127829 4318 6993 4332 10493 160364 3240 3482 79930 56729 8804 23218 6657 5553 5795 1075 140885 5787 5788 5547 6518 4353 1088 353189 25840 1084 56954 6402 11322 5799 5315 5579 23317 29099 55754 10120 8836 11333 5328 5329 7532 23406 8972 64114 126014 8621 3043 4125 4126 89777 57826 170482 23412 683 684 566 6317 11314 9961 7525 5588 4033 8876 25801 210 5236 64386 51071 10326 101 56888 55313 7305 8635 10321 9725 10562 326624 441864 6590 84329 84443 5371 51646 5273 54918 5036 138050 29952 199675 5269 8778 53831 5284 26 154664 9522 9535 8566 401258 5049 51316 6036 9545 11026 55 7133 6286 11031 356 25798 25797 7130 6282 387921 2919 374403 10394 11240 290 175 178 150372 10159 80196 7276 23114 3903 55832 25 23593 10043 10288 1727 9342 9588 253260 100049587 3916 51806 222487 83858 81567 2950 22918 51816 1512 1992 57126 8288 7077 1522 9145 57020 258010 1654 1774 84766 58485 93100 84514 79169 2992 3608 2517 53916 8463 53917 26578 1315 5912 84658 5806 23071 84418 10273 2896 4831 6351 6352 6356 6097 6348 6347 6349 6095 6364 6363 6367 1230 2920 3576 58484 57154 3845 3627 5451 1437 1436 3717 3929 2244 2266 7414 3587 6776 9402 3123 3122 3120 55740 2243 3119 3937 3118 1445 3117 3115 3113 915 27040 916 917 9398 2533 3127 3126 3125 3702 2534 4651 6850 4620 3055 4641 3932 2214 2147 5627 1213 1211 51128 10577 5034 160 161 163 1175 1173 3727 1785 2354 1958 5292 115361 2635 115362 2634 5229 10019 8835 9306 6503 84174 2316 10010 9641 3665 7408 8945 4775 4860 272 353 4772 5534 4210 10910 5530 5532 9051 146433 139716 54920 9020 10892 84433 64170 64581 5971 163351 203068 10540 4751 80184 201254 10121 11258 23200 79895 6622 5617 25780 118788 4794 933 5966 27071 80143 3563 59067 3560 3581 84868 2885 3578 1439 50615 1438 3568 3601 3567 3600 6777 23250 3965 196527 10396 7124 9493 1052 6778 10112 8694 2171 51082 84818 23765 4153 9533 948 26007 3605 112744 4128 10555 5660 2760 2717 1759 410 2208 427 6300 5603 26052 1398 8772 2688 7332 28988 9655 929 3660 79792 3659 6386 1154 3552 2339 6709 3553 837 838 353376 841 1828 11035 1832 2934 148022 14 5317 3146 23643 7099 3606 57162 1687 102 5663 23385 80028 23194 10855 6382 4067 3635 695 146850 5294 7006 23533 6175 9987 9049 6775 9446 4507 375 3716 3936 654483 3313 5478 6647 5898 6845 6888 7297 4282 5055 3595 3594 3593 3592 1072 3434 27250 4600 302 9470 1265 2317 3586 1982 5721 8672 4478 317649 2939 5495 5306 4599 829 5581 3838 10768 8411 4064 80231 3663 6197 64145 6196 9450 9252 6195 4205 24145 6868 56667 57630 832 10970 941 942 5880 50852 4690 5783 2185 6793 3163 5338 5781 4893 245972 245973 7535 8503 117145 155066 9114 51606 8660 5594 5595 30849 9550 523 525 526 527 1509 208 528 24137 529 8992 26153 391 26999 5289 6654 90423 3265 22920 127124 23545 51382 2887 2247 57761 54509 533 2323 10810 534 2322 535 10312 50617 5295 5296 5770 6464 9371 158747 9296 5290 5291 63916 5170 9846 54106 3667 81622 7098 808 58480 1794 1793 3797 3832 23197 815 3835 6714 816 285643 817 818 51529 7321 8881 64682 11065 8697 7324 10393 29945 25852 27338 29882 246184 983 996 51434 10133 51433 56992 23291 3082 5265 7979 4361 351 197 12 9140 9474 2162 1 3920 7076 383 245936 6712 245937 245938 245939 6278 5068 6810 5266 4057 6279 6037 6813 613210 10487 116842 3309 613211 245930 728358 245932 245934 503841 671 641517 475 710 613209 55600 400830 5473 51248 5657 10578 130120 54209 729230 967 4069 1671 5004 1670 245940 338324 6280 7097 7096 1191 55894 1668 57119 100133267 5005 140683 140881 51297 5768 57115 920 6039 6556 128859 1669 245913 8993 5320 503618 503614 245911 1901 122665 117285 80341 1511 1235 114770 114771 1113 140850 1673 823 1672 1991 538 417 6406 3934 245927 245928 245929 81623 84659 3347 3346 820 149954 117159 5645 644414 92747 5646 504180 47 3695 11001 3386 9218 3385 3384 3383 595 83439 1026 1499 51176 6932 6934 7087 8894 3417 1965 467 7412 1968 30 4609 6804 4343 192669 23112 27327 999 26523 4613 192670 27161 7132 57690 5580 9861 3428 6233 197358 9261 3312 7316 3162 10213 23480 8741 7534 8021 5706 5707 5708 5709 1981 207 5700 5701 5702 7529 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 1432 11047 5713 5714 5690 5691 6844 5692 5693 5694 7311 10952 5695 7314 3304 5687 5688 5600 5689 842 317 836 1675 3004 629 718 5045 90865 9173 11127 7431 8452 9844 10053 8907 8905 6093 130340 1174 162 164 5930 3105 940 567 926 10576 22954 3661 340061 29110 147945 81844 23220 81030 11277 6737 51428 2990 23608 3074 4734 2444 411 2720 2342 3320 5335 867 1019 51343 6502 1027 8970 8331 4297 8337 128312 8334 8335 2033 1974 8370 1973 55766 8968 8341 8342 8347 8348 94239 8345 3013 3570 8340 8338 255626 6774 3021 653604 3018 3017 85236 3014 8349 474382 54145 1441 29116 1143 5476 27248 79139 51009 6400 11160 4758 10613 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME DATABASE ID RELEASE 95%159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins 2621 2147 632 5045 2158 2155 8858 5624 5627 2159 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 95%163767 PP2A-mediated dephosphorylation of key metabolic factors 5207 5528 5515 5516 5518 5519 51085 ACTIVATION OF INFLAMMATORY CASPASES%REACTOME DATABASE ID RELEASE 95%9686114 Activation of inflammatory caspases 3606 808 3553 1992 836 837 838 79792 IRAK1 RECRUITS IKK COMPLEX%REACTOME DATABASE ID RELEASE 95%937039 IRAK1 recruits IKK complex 7335 57162 8517 7334 57161 3551 1147 246330 7189 3654 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME%R-HSA-350562.6 Regulation of ornithine decarboxylase (ODC) 5706 5707 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 5690 5691 5692 1728 5693 5694 7979 5695 9861 5687 4947 5688 51582 5689 51686 4946 4953 10213 PONATINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702614 ponatinib-resistant FLT3 mutants 2322 CHOLESTEROL BIOSYNTHESIS FROM ZYMOSTEROL (MODIFIED KANDUTSCH-RUSSELL PATHWAY)%REACTOME DATABASE ID RELEASE 95%9969901 Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway) 1717 1718 6309 10682 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%R-HSA-193634.4 Axonal growth inhibition (RHOA activation) 396 4168 4804 387 4099 57142 4974 84894 NICOTINATE METABOLISM%REACTOME%R-HSA-196807.8 Nicotinate metabolism 27231 160728 952 349565 65220 10135 93100 54981 4837 83594 23057 23475 9390 128240 143 92014 133686 64802 56965 83666 84875 79668 54956 54625 4907 683 55191 55328 55739 NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-112310.8 Neurotransmitter release cycle 27163 6853 8573 6804 55327 320 1103 2572 64130 2571 57030 8825 6572 10550 3312 9256 6582 6571 8541 8497 8499 27165 22999 8500 2744 6540 6580 10497 18 80331 10815 5864 140679 6616 6857 6529 7915 6511 8224 6854 6506 6505 6507 6844 60482 6538 4128 6512 6539 54407 RHOU GTPASE CYCLE%REACTOME%R-HSA-9013420.5 RHOU GTPase cycle 8826 4690 8874 1969 6709 9815 257106 5063 79834 9146 10254 2185 10298 667 8027 9352 9459 81839 5295 5296 9231 4646 998 50618 11180 11060 58480 55789 1213 57514 23380 5058 8440 6711 28964 6714 8239 50855 5062 DNA REPAIR%REACTOME%R-HSA-73894.5 DNA Repair 7320 10450 91603 7318 11201 199990 27339 55120 2189 91442 80233 55215 2175 2188 2187 57697 2178 51567 79840 55775 1161 10721 55183 27343 9716 64421 27434 7398 51514 51548 8451 5981 4437 8533 2073 2072 64708 56655 85015 7515 7334 9557 7336 10987 10980 55666 5426 5427 3980 51426 50813 4968 10038 2067 10920 1642 54107 7507 7508 10401 6047 23030 121642 8505 54936 79068 54890 328 221120 51008 84164 10973 4350 348654 4436 146956 197342 84464 23514 80198 1017 79008 5599 2237 8924 7341 7329 64858 6233 57654 22909 9937 353497 9978 9246 7316 54778 93973 11200 8314 5440 5441 4331 1022 2071 2966 2965 7353 165918 2068 5434 7468 5435 5436 5437 1069 5438 5439 2968 7158 2967 404672 5430 5431 5432 5433 902 5429 54962 9025 151987 5893 5531 8914 201254 3838 63979 51750 7311 5111 7314 79913 54617 84142 9577 5886 4798 5887 86 7706 9100 51588 60 125476 57599 2873 5423 51138 9318 2177 2176 7157 54891 29086 4292 7874 2547 1643 7520 3981 7518 5395 51720 8607 25 7528 142 10714 5424 5425 57804 29844 3978 2956 63967 2070 5536 7415 322 2140 2139 8970 8331 2138 8337 128312 79184 8334 8335 83932 283899 9768 83444 8370 124739 55766 10445 8341 8342 8347 8930 56852 8348 8290 94239 55247 8345 23583 5591 26277 3013 252969 25913 8340 7013 65057 7014 8338 79661 255626 54386 6996 4913 3018 3017 4255 85236 3014 8349 474382 378708 54145 9656 9682 5980 10459 51455 51035 22976 8554 11284 6612 6613 8467 9636 8178 7486 5982 5883 5884 5983 116028 6917 3364 472 10635 672 29089 675 84126 1111 57461 83990 144715 83695 5810 7516 10111 5932 7517 7979 2074 4361 7156 5890 9156 5892 4683 55732 11073 9031 580 10524 641 56949 1763 545 6117 5984 5985 890 6119 8900 79728 5888 6118 80010 5889 SIGNALING BY MEMBRANE-TETHERED FUSIONS OF PDGFRA OR PDGFRB%REACTOME%R-HSA-9673768.2 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB 23189 2120 51411 2803 3791 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 95%77387 Insulin receptor recycling 127124 23545 51382 3416 533 534 535 537 10312 50617 5770 9296 245972 245973 3630 155066 9114 51606 5792 9550 523 525 526 527 1509 3643 528 529 8992 90423 REGULATION OF RAS BY GAPS%REACTOME DATABASE ID RELEASE 95%5658442 Regulation of RAS by GAPs 8452 161742 9462 4763 399473 200734 9861 6233 9978 7316 10213 8437 5706 5707 5708 5709 10156 22821 5700 5701 5702 153090 5704 5705 5682 5683 8831 5684 5685 5686 5717 64926 5718 5719 5922 5921 4893 11047 5713 5714 5690 5691 5692 5693 5694 84078 7311 7979 5695 7314 5687 5688 5689 3265 SIGNALING BY ALK IN CANCER%REACTOME%R-HSA-9700206.5 Signaling by ALK in cancer 597 3065 27436 3662 8878 80304 1026 5599 2305 8496 57448 1051 5601 7170 5295 53335 10342 6772 5296 7171 4627 4170 471 5290 3092 5291 7157 22872 4343 6238 192669 9648 3667 26523 192670 27161 9451 3799 57690 6233 50616 9978 7316 2885 2335 4193 5551 3831 7175 29851 833 7414 3587 5335 51530 6801 1937 6776 7291 7297 4869 891 5903 10817 3586 3002 4478 5495 5925 6194 5573 238 4008 7535 5777 7311 7314 5594 5595 8454 10818 1213 57674 3726 1786 6774 6500 3725 1639 ER-PHAGOSOME PATHWAY%REACTOME DATABASE ID RELEASE 95%1236974 ER-Phagosome pathway 2923 3551 4615 3107 6810 3106 6279 3105 567 3134 3133 6280 7097 55176 7096 9861 6233 948 6890 6892 8773 7316 6891 695 10213 23480 929 9341 5706 8673 3135 5707 2244 2266 5708 114609 5709 5696 5700 5701 29927 2243 5702 811 5704 5705 5682 5683 5684 5685 5686 5721 5717 5718 5719 5698 5720 5699 11047 5713 10333 5714 5690 6271 5691 5692 8517 5693 5694 10952 7311 3146 7979 5695 23643 7314 9554 7099 5687 5688 5689 1147 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME%R-HSA-77310.3 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 3030 1892 33 3033 3032 SUMOYLATION%REACTOME DATABASE ID RELEASE 95%2990846 SUMOylation 51588 5371 3183 1655 7157 7518 6790 348995 9883 5465 6396 5987 9641 129401 9688 57122 23225 4927 6670 23165 3090 668 55746 55706 23636 9631 5468 7175 9112 9972 11097 23279 8086 5241 23511 53371 4869 7421 8480 5970 79023 3190 142 79902 10762 5903 2099 1487 1616 2908 6672 8243 9126 2033 10735 8370 8517 5885 10274 57591 7508 10401 6256 6996 4306 5914 3065 25942 197370 1029 493861 7181 9656 286053 23137 6095 79677 56160 54780 8648 7376 5905 51564 9612 10891 8204 9189 8924 332 8535 4152 55143 6304 6294 7341 10210 6045 9994 1107 7022 115426 83746 4929 7690 648 5610 7021 8554 10521 3619 6015 7329 3066 23468 9759 1912 2516 1911 9212 29843 23512 23314 80012 57332 84733 10155 6612 7703 6613 59348 367 4791 7428 3622 7155 7150 8021 4193 165918 1069 7158 7486 7068 205564 10499 10055 59343 51602 25950 10054 672 5893 1387 4286 4792 5111 1789 1788 641 1786 6117 11315 7153 28996 DEFECTIVE ABCG5 CAUSES SITOSTEROLEMIA%REACTOME%R-HSA-5679096.3 Defective ABCG5 causes sitosterolemia 64241 64240 OTC VARIANTS CAUSE OTC DEFICIENCY%REACTOME%R-HSA-9956522.1 OTC variants cause OTC deficiency 5009 BIOSYNTHESIS OF PROTECTINS%REACTOME%R-HSA-9018681.2 Biosynthesis of protectins 246 1544 4048 1543 MAP KINASE ACTIVATION%REACTOME%R-HSA-450294.5 MAP kinase activation 3551 5599 3656 257397 6885 23118 1326 5609 466 6416 4208 5601 7867 5602 5606 5519 7189 79155 5515 5516 5518 6233 8767 9261 3654 7335 10454 7316 5528 64127 8945 5608 23291 7334 1432 8517 10392 7311 6197 7314 6196 5594 4790 5595 9252 8454 6195 1386 4205 2353 5600 2002 5598 6500 5604 3725 51231 1849 1147 1848 1846 1845 BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME DATABASE ID RELEASE 95%9026395 Biosynthesis of DHA-derived sulfido conjugates 2948 4056 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME%R-HSA-69202.5 Cyclin E associated events during G1 S transition 595 91750 993 132660 1017 7465 286826 1026 1875 55957 1874 5928 4609 5934 9861 6233 7316 10213 4331 1022 5706 5707 5708 5709 7027 207 1019 5700 5701 5702 898 5704 6502 5705 5682 5683 9134 5684 1027 5685 902 5686 4149 7029 1869 5717 5718 5925 5719 91768 11047 5713 5714 5690 5691 5692 5693 5694 1163 7311 7979 5695 7314 8454 5687 5688 5689 208 10000 890 8900 5753 6500 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 95%380320 Recruitment of NuMA to mitotic centrosomes 10383 10382 1781 4926 1778 7846 5566 9793 7277 5518 9738 9662 7840 11064 22994 22995 7283 10733 80321 203068 114791 55722 1454 1453 3320 55125 9814 85378 11190 115106 79441 95681 10426 27175 1069 653784 54801 983 10142 9702 10540 8655 5347 5108 11116 4751 29922 55142 22897 27229 54930 5116 79959 80184 93323 5577 23354 22981 440145 8481 10844 80254 121441 55755 23332 7532 10806 10121 7531 55559 8636 22919 11258 80097 5048 84131 4957 55835 54820 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 95%112043 PLC beta mediated events 113 114 5332 115 107 108 109 196883 5566 5567 5568 2767 3710 5153 5573 5575 2769 5576 5577 5582 5613 156 3838 5137 10645 10768 26960 5321 84254 2776 814 808 5594 5580 5330 5331 23236 5136 815 5578 3708 9630 3709 816 817 818 111 112 INTERFERON SIGNALING%REACTOME DATABASE ID RELEASE 95%913531 Interferon Signaling 4904 5611 5894 3454 3309 1660 1958 8575 6895 5292 7318 115361 2635 115362 2634 5229 2316 199990 55120 3665 2189 91442 80233 2175 2188 2187 57697 2178 3660 3659 2339 4869 3837 2209 7334 5771 103 4502 3306 3305 3839 2633 402569 8651 3840 3459 3841 3460 54920 3383 3551 5300 3107 3106 8894 201626 6041 1965 4938 4940 8638 7412 1968 7341 3134 3133 1977 7329 163351 5580 6233 960 57506 9246 2289 3312 7316 8678 8021 5608 3135 3716 1981 5696 7297 3434 4600 9470 2317 4092 1982 8672 317649 834 5495 4599 11274 201254 3838 7311 23586 3663 7314 3304 3458 51191 684 7706 5045 60 5371 3105 6772 567 6622 2176 7157 3661 9451 6737 8877 348995 9883 8519 6396 4734 129401 9688 57122 23225 3836 4927 23165 55746 55706 2342 23636 9631 4690 7175 81603 9972 10410 5335 11097 23279 55223 8086 23511 91543 53371 3430 8480 3664 79023 3669 79902 10762 3429 64135 10612 5903 3437 55128 3433 10964 117854 23321 51127 6059 10379 7726 85363 10475 3394 3608 6672 5781 4261 10581 9830 23650 10107 10346 1974 10437 1973 25939 8517 4281 24138 79097 11074 53840 54739 5594 80128 5595 80263 23087 388646 2537 4684 6774 3609 1147 378708 51447 3662 9775 5770 5519 3442 3441 25820 3440 5610 71 8554 3452 5515 3451 5516 3449 5518 3448 3447 4939 3446 3445 3444 3443 5525 815 3456 2810 9636 816 817 818 3717 7324 3123 3122 3120 3119 983 3118 3117 3115 3113 5724 3127 3126 3125 5777 9021 22926 6773 DIGESTION OF DIETARY LIPID%REACTOME%R-HSA-192456.7 Digestion of dietary lipid 8513 119548 1056 5407 5406 5408 1208 HOST INTERACTIONS OF HIV FACTORS%REACTOME DATABASE ID RELEASE 95%162909 Host Interactions of HIV factors 163 1104 9844 10053 8907 8905 1175 130340 1173 1174 162 55690 5902 164 3105 940 567 926 348995 9883 6396 129401 9688 920 291 292 57122 293 23225 3836 4927 3159 23165 8945 11168 55746 55706 23636 9631 7175 9972 11097 23279 8086 23511 53371 4869 8480 79023 79902 10762 8815 3837 5903 51606 5879 5905 5901 9861 6233 1794 9978 7316 6921 6923 7514 10213 8021 375 5062 5706 5707 5708 5709 5478 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 1025 2534 3055 11047 3932 904 5713 5714 5690 5691 5692 5693 5694 8065 7311 7979 5695 7314 5687 5688 5689 6500 160 161 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 95%109606 Intrinsic Pathway for Apoptosis 5366 572 637 1029 8626 5599 581 27113 7157 140735 2810 90427 7534 79792 57099 708 7027 207 7529 841 8655 23368 3002 7029 1869 596 5533 598 10971 22900 5534 55075 7532 7159 5594 7531 10018 5595 7533 208 7161 578 10000 51074 6774 331 1687 840 4836 842 317 836 54205 56616 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%R-HSA-3299685.7 Detoxification of Reactive Oxygen Species 1536 7296 1535 6647 2950 5052 538 4688 4689 7295 7001 2876 475 493869 79400 30001 257202 10935 847 6649 343 318 2880 2878 10587 50507 2882 9973 2877 5034 653361 6648 54205 25828 9588 DISEASES OF MISMATCH REPAIR (MMR)%REACTOME DATABASE ID RELEASE 95%5423599 Diseases of Mismatch Repair (MMR) 2956 4436 4292 5395 4437 DEFECTIVE ALG2 CAUSES CDG-1I%REACTOME DATABASE ID RELEASE 95%4549349 Defective ALG2 causes CDG-1i 85365 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME DATABASE ID RELEASE 95%111932 CaMK IV-mediated phosphorylation of CREB 3838 10645 815 84254 814 808 816 817 818 REGULATION OF ENDOGENOUS RETROELEMENTS%REACTOME DATABASE ID RELEASE 95%9842860 Regulation of endogenous retroelements 55422 60 10793 162655 5928 340252 79862 285676 7562 5931 7576 65251 1108 57504 162967 162963 7581 9112 23517 53615 284306 197320 8970 8331 8337 128312 8334 6595 8335 6597 25799 6599 8370 6598 55766 8968 8341 8342 8347 8348 94239 8345 3013 7695 8340 8338 6601 255626 6603 6602 22880 6605 3021 653604 6604 3018 3017 85236 3014 57693 8349 474382 57459 7700 54145 3065 54815 9422 79813 8289 10919 29947 9869 51535 1107 155054 7329 3066 91661 23468 55596 23272 147686 10179 10155 5977 6613 6940 605 8110 9219 147646 54737 125893 147658 26039 55729 6760 84911 90853 57492 81931 9274 9275 90075 1788 8193 113835 143689 7767 86 SIGNALING BY PDGFRA TRANSMEMBRANE, JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS%REACTOME%R-HSA-9673767.2 Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 6774 5295 5296 6772 5156 6654 4893 5290 5291 3265 COSTIMULATION BY THE CD28 FAMILY%REACTOME DATABASE ID RELEASE 95%388841 Costimulation by the CD28 family 91445 84661 6048 11091 91319 5133 23476 10956 5928 5929 3727 2354 5931 9070 920 8945 3659 23308 5970 58508 10987 7409 84061 1650 595 83439 100128731 1499 6185 7991 51176 6932 6934 5879 6184 5562 58505 5563 201595 5564 5565 467 746 9020 10413 1603 3703 4609 51422 4343 192669 55615 23112 27327 26523 4613 5571 192670 27161 64223 57690 9861 6233 2034 53632 2475 9978 3091 4067 7316 146850 5294 23533 10213 1493 5062 5706 3716 5707 5708 5709 207 5700 5701 5702 5704 5705 5682 5683 4751 5684 5685 5686 5717 5718 5719 1460 11047 5713 1459 5714 5690 5691 1457 5692 5693 5694 7311 5293 5695 7532 7314 4790 5687 5688 5689 5058 7525 79109 2146 8452 6772 940 8405 10331 80380 941 942 8726 253260 1019 5063 7415 8970 8331 25937 4297 8337 8463 5781 128312 8334 8335 8503 117145 2033 998 8370 55766 8968 8341 8342 8347 8348 94239 8345 3013 8340 8338 208 255626 6774 3021 653604 3018 3017 85236 3014 8349 474382 54145 57761 7004 1326 7003 7005 5295 5296 5519 5290 5291 5170 5515 5516 5518 23512 5525 5526 2932 5527 5528 5529 4791 29126 9402 3123 3122 3120 3119 3118 1445 3117 3115 3113 915 916 917 3127 3126 3125 4780 2534 1387 27248 3932 79139 151888 51009 8764 5777 6400 7979 8454 11160 2353 10000 142678 6500 3725 10613 SELECTIVE AUTOPHAGY%REACTOME DATABASE ID RELEASE 95%9663891 Selective autophagy 8100 1781 1780 10013 1778 8878 5563 1783 10226 5564 5565 1080 123 51001 51422 29110 140735 5571 9804 54543 7323 6233 7322 65018 2034 4077 9927 53632 81631 5830 55669 7335 3297 3312 7332 7316 9868 84749 10452 3320 10133 8655 100188893 7415 7334 7417 472 5116 7416 7419 5071 401505 1460 1459 56993 1457 7311 7314 9140 8408 9474 79065 84557 51143 139341 1068 11315 200894 PLASMA LIPOPROTEIN ASSEMBLY%REACTOME%R-HSA-8963898.3 Plasma lipoprotein assembly 29801 2 346 348 335 336 337 5566 5567 338 4547 5568 51128 345 5034 19 341 344 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 95%389357 CD28 dependent PI3K Akt signaling 253260 207 57761 1326 5295 5296 940 2534 9020 3932 5290 5291 5170 8503 117145 55615 5293 64223 2475 941 942 208 10000 146850 5294 23533 79109 HEME DEGRADATION%REACTOME%R-HSA-189483.5 Heme degradation 2938 213 2168 644 645 28234 3163 10599 3162 1244 54658 9429 54657 4363 METABOLISM OF STEROID HORMONES%REACTOME%R-HSA-196071.5 Metabolism of steroid hormones 134429 231 1583 6715 1584 6716 3284 412 3283 3291 5443 3290 3294 1081 51171 3292 51170 1589 441282 3972 1588 1585 866 10948 51144 147323 83930 6770 1586 3293 706 2232 112812 79644 9256 2230 CREB PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 95%199920 CREB phosphorylation 466 6197 6196 9252 6195 9261 SIGNALING BY NOTCH1 IN CANCER%REACTOME%R-HSA-2644603.5 Signaling by NOTCH1 in Cancer 83464 51107 3065 10013 10014 6907 79718 9734 6868 51564 3714 9612 8841 9611 23493 3516 4609 892 3066 9759 23462 8850 6233 3280 9978 79885 7316 55869 22938 55534 83933 9794 2648 1387 2033 28514 1024 182 7311 7314 84441 8454 9148 10046 54492 4851 142678 26508 388585 6500 57534 102 54567 5663 23385 55851 5664 DUAL INCISION IN TC-NER%REACTOME%R-HSA-6782135.4 Dual incision in TC-NER 10450 91603 7874 6233 57654 9978 27339 7316 5440 5441 4331 1022 2071 2966 1161 2965 9716 2068 5434 5435 5436 5437 5438 10714 5439 5424 2968 8451 5425 2967 5981 404672 57804 5430 2073 5431 2072 5432 5982 5433 56655 902 5983 6917 5426 5427 57461 51426 2067 1642 54107 7311 7507 2074 5111 7314 56949 6117 5984 5985 6119 6118 SIGNALING BY ALK FUSIONS AND ACTIVATED POINT MUTANTS%REACTOME%R-HSA-9725370.3 Signaling by ALK fusions and activated point mutants 597 3065 27436 3662 8878 80304 1026 5599 2305 8496 57448 1051 5601 7170 5295 53335 10342 6772 5296 7171 4627 4170 471 5290 3092 5291 7157 22872 4343 6238 192669 9648 3667 26523 192670 27161 9451 3799 57690 6233 50616 9978 7316 2885 2335 4193 5551 3831 7175 29851 833 7414 3587 5335 51530 6801 1937 6776 7291 7297 4869 891 5903 10817 3586 3002 4478 5495 5925 6194 5573 238 4008 7535 5777 7311 7314 5594 5595 8454 10818 1213 57674 3726 1786 6774 6500 3725 1639 RHOA GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%8980692 RHOA GTPase cycle 55914 9475 6093 65124 55200 57636 115557 55219 26030 5825 80243 64283 79658 83478 9754 2040 6811 91452 57514 4649 64333 116985 2319 117289 284119 57522 3895 9912 8826 343578 9411 9414 50619 55852 708 8086 58504 11113 257106 10144 25963 23526 4650 79822 393 6793 5585 396 5586 3163 5337 91010 51291 23779 3728 54443 10134 9824 90627 7204 89839 57569 55160 23365 10395 9181 128272 57580 10160 29941 10211 25894 85415 1894 6242 10451 128239 7410 84317 9748 23370 25791 9826 9828 387 7409 81624 22899 50649 8997 7984 29 23256 8874 57449 70 23002 65992 23263 5099 50650 9217 55831 9639 10276 55701 93663 537 9138 4168 7074 5295 5296 11214 5924 84986 114822 1794 1729 23197 8773 2909 9743 57584 392 9341 394 395 397 10652 3998 81839 23092 143872 10424 64411 29127 4983 613 857 8987 3930 55789 4162 7112 7037 80728 116984 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%R-HSA-442380.4 Zinc influx into cells by the SLC39 gene family 23516 27173 55630 64116 7922 29986 283375 57181 25800 29985 REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 95%5218859 Regulated Necrosis 8797 8626 581 7186 7157 355 356 6233 8772 7332 7316 79643 51652 197259 2319 3660 79792 3659 6386 11140 91782 3320 8737 3552 329 92421 3553 83737 1991 837 838 841 11035 330 3002 834 27243 128866 5071 10015 29082 8473 25978 10273 7311 3146 8717 7314 10211 8743 3606 57162 578 331 1687 836 54205 8795 ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME%R-HSA-199977.6 ER to Golgi Anterograde Transport 6708 6710 6712 375056 10342 10959 22872 8729 2804 6811 9871 378 9632 832 6396 1294 26286 57731 10427 6711 966 287 288 1604 51332 2801 6709 1522 8655 84364 58485 1315 3630 10113 9554 9570 26958 8774 8775 51143 55860 51164 11015 55738 830 10671 1639 93661 23256 84516 10945 1781 63908 51014 1780 57511 1778 23423 51399 372 84342 91949 1783 4905 381 51272 9527 140735 22796 9382 2890 10972 5537 25839 79090 9276 22870 11070 9117 11196 254263 375 81562 11316 1453 27095 83548 149111 9919 89866 7109 4253 6399 286 10466 23243 2348 10175 126003 22818 25956 10802 55014 10652 51693 3998 122553 1314 1075 10540 10484 54732 83696 90411 51226 10282 26984 55291 79748 128637 374 10960 829 22820 377 11014 5265 81876 5861 2153 10121 11258 64689 7039 51128 8615 2157 LGK974 INHIBITS PORCN%REACTOME%R-HSA-5340573.4 LGK974 inhibits PORCN 64840 RORA,B,C AND NR1D1 (REV-ERBA) REGULATE GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 2033 5469 6097 1374 9572 6095 10498 6907 80205 8648 5465 79718 85441 6256 10499 96764 8204 10891 6604 8841 9611 6720 1387 23054 REGULATION OF TBK1, IKKΕ (IKBKE)-MEDIATED ACTIVATION OF IRF3, IRF7%REACTOME DATABASE ID RELEASE 95%9824878 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 29110 7311 7314 23643 7099 6233 353376 10133 10010 9641 7316 929 7187 148022 FCERI MEDIATED NF-KB ACTIVATION%REACTOME DATABASE ID RELEASE 95%2871837 FCERI mediated NF-kB activation 3551 10235 257397 6885 23118 10125 997 10892 84433 7189 5170 9861 6233 7322 7335 4067 10454 7316 10213 8945 7321 5706 5707 5708 5709 5700 115727 5701 5970 5702 5704 5705 5682 23291 5683 5684 5685 5686 7334 5717 5718 5719 11047 5713 5714 5690 5691 5692 8517 4792 5693 5694 7311 7979 5695 7314 4790 8454 5687 5688 5689 8915 6500 5588 1147 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 95%196854 Metabolism of vitamins and cofactors 335 336 337 55788 3949 345 4846 5167 5593 55312 113278 80308 51248 55065 79581 54 7804 143 1109 56965 83666 84875 79668 54956 54625 338 25902 6573 160428 2350 441024 200895 81034 4522 4524 10840 10797 10588 9962 9963 1528 10243 83594 23057 5646 23475 8884 128240 2194 27010 92014 64802 4907 5644 31 55191 79178 55328 4338 55739 4363 80704 1504 27231 952 440387 55034 349565 65220 8034 10135 8875 5168 6383 9227 10560 5950 5169 3417 221914 60386 80025 284439 54981 9672 254552 5947 10082 80347 6385 53354 6470 79877 79646 60496 2262 6382 79717 55229 60490 2239 9390 326625 27304 4036 2719 2817 6947 27235 4552 9446 207 2694 27249 25974 4594 166785 119391 683 64087 5096 686 5091 56922 3141 32 8876 5095 56910 51293 6948 6515 8566 133686 7276 4548 1727 4035 29967 3320 154807 83875 7274 1645 79001 29914 5948 160728 26020 54884 57016 53630 5406 55937 1208 93100 151056 6472 48 375790 3339 344 348 5805 2644 2643 316 6697 808 55163 51805 57017 57107 56997 23590 10229 84842 79934 51004 51117 84274 51109 8644 4837 113235 6513 5826 26119 338328 81693 1719 4023 8029 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 95%75953 RNA Polymerase II Transcription Initiation 2071 2966 2965 83860 2963 2962 8148 2068 5434 6872 5435 5436 51616 6874 5437 6873 5438 5439 2968 2967 404672 6881 5430 5431 138474 54457 5432 5433 6908 902 6880 6883 2961 2960 6882 6884 2959 2958 129685 2957 6875 6878 6877 6879 5440 5441 4331 1022 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 95%379716 Cytosolic tRNA aminoacylation 3035 833 6897 10056 2617 51520 5464 2193 1615 3376 7965 9521 9255 6301 5859 4141 2058 7453 16 4677 5917 3735 8565 RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-112409.5 RAF-independent MAPK1 3 activation 3716 7297 5594 5595 1844 3569 1852 1843 1850 983 1847 3570 11221 80824 5604 5605 1849 1848 8682 5781 1846 3717 TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME DATABASE ID RELEASE 95%190827 Transport of connexins along the secretory pathway 2697 2706 2705 VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%R-HSA-196819.4 Vitamin B1 (thiamin) metabolism 80704 27010 79178 10560 60386 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME DATABASE ID RELEASE 95%174154 APC C:Cdc20 mediated degradation of Securin 9861 6233 7316 10213 51529 7321 5706 8881 64682 5707 25906 5708 11065 8697 5709 7324 10393 29945 27338 119504 5700 5701 29882 5702 246184 996 5704 51434 5705 51433 5682 5683 5684 5685 5686 5717 5718 5719 991 11047 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 5687 5688 5689 9232 ACTIVATION OF AMPA RECEPTORS%REACTOME%R-HSA-399710.4 Activation of AMPA receptors 2892 2893 2891 2890 PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME%R-HSA-5693607.4 Processing of DNA double-strand break ends 51588 54145 9656 1017 8924 29086 7329 6233 51720 6613 7316 165918 7468 51548 7158 7486 63967 5982 5883 5884 5983 7334 116028 3364 8970 472 7336 54962 9025 672 151987 128312 84126 5531 79184 1111 8914 83990 144715 83695 8370 5810 10111 5932 7311 8341 4361 7314 8342 7156 8347 8290 9156 8348 6047 8345 84142 4683 11073 9577 580 8340 10524 641 1763 545 6117 255626 5984 5985 890 6119 8900 3018 6118 3017 85236 80010 3014 8349 BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 95%450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 51010 167227 51013 207 54464 11340 7529 118460 9261 23404 54512 677 22894 55802 5393 56915 23016 REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 95%975578 Reactions specific to the complex N-glycan synthesis pathway 9486 64377 2525 3972 2530 4122 4247 2517 1081 4124 DEFECTIVE F9 SECRETION%REACTOME%R-HSA-9673218.2 Defective F9 secretion 2158 KIDNEY DEVELOPMENT%REACTOME DATABASE ID RELEASE 95%9830369 Kidney development 57526 10406 3203 9353 7849 2247 6092 1499 2018 3400 3688 130497 2138 8516 7484 6928 153572 51316 7481 5979 5455 28514 79192 182 3975 5076 6495 54361 6299 7490 2296 652 3172 3955 3207 10736 255743 2303 3227 3237 26585 2625 2122 3214 2668 2674 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%R-HSA-5140745.2 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 163 4919 7855 1213 2535 1211 1175 1173 7474 160 1212 161 4920 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME DATABASE ID RELEASE 95%1237044 Erythrocytes take up carbon dioxide and release oxygen 51706 760 6005 6521 762 3040 759 606495 51167 358 51700 3043 CROSSLINKING OF COLLAGEN FIBRILS%REACTOME%R-HSA-2243919.5 Crosslinking of collagen fibrils 84171 649 4015 4016 5118 7837 4017 84695 7093 7092 SARS-COV-2 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME DATABASE ID RELEASE 95%9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways 208 10000 2810 7532 207 7531 857 7533 7534 7529 10971 5170 MET PROMOTES CELL MOTILITY%REACTOME DATABASE ID RELEASE 95%8875878 MET promotes cell motility 3918 284217 3908 4233 3909 3910 3911 3912 5906 5908 5879 1399 3673 3688 85440 3082 2549 2889 84951 64759 1398 3675 5747 6714 3913 3914 3915 10319 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO ABCA4 LOSS OF FUNCTION%REACTOME%R-HSA-9918454.1 Defective visual phototransduction due to ABCA4 loss of function 24 HEME SIGNALING%REACTOME DATABASE ID RELEASE 95%9707616 Heme signaling 5469 4209 335 4862 6095 10498 6907 80205 8648 79718 571 23373 406 85441 10499 10743 96764 4208 10891 9575 8204 64784 8841 4780 9611 200186 10424 1387 23054 7975 113235 2033 3040 23643 9572 1386 3043 338 7099 5465 23411 6256 7514 3162 6604 51266 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 95%389359 CD28 dependent Vav1 pathway 998 5879 941 942 5058 940 7409 2534 5063 3932 5062 SIGNALING BY FGFR1 AMPLIFICATION MUTANTS%REACTOME DATABASE ID RELEASE 95%1839120 Signaling by FGFR1 amplification mutants CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-HSA-8856828.5 Clathrin-mediated endocytosis 10618 163 554 4952 4074 10254 1759 8027 1601 1175 1173 3949 1785 8218 2873 408 51138 409 1080 9318 3092 23048 54874 143425 7018 338 6572 26052 920 8673 1950 867 1956 1129 9146 6857 8533 5868 64708 9185 2580 950 10987 22848 8976 10980 286749 90019 50813 112574 23208 10920 115548 1856 8322 25977 3267 85021 8301 9829 9856 23149 85439 51429 55738 9892 1839 273 274 6453 55707 11252 9322 6456 84251 6455 5286 2060 6457 1861 27348 8674 29763 22905 9026 29988 29993 29978 29979 1212 50618 8871 4036 382 23396 8867 2017 6233 127833 10109 10552 10093 10092 4738 3312 10094 10097 7316 10096 5869 26130 5878 9341 6845 3482 551 915 917 154 374 156 6844 7311 6869 7314 185 3575 29924 26119 7039 58513 685 1213 1211 255324 2069 7037 157 7474 160 30011 161 HEDGEHOG 'ON' STATE%REACTOME%R-HSA-5632684.2 Hedgehog 'on' state 374654 6608 11127 8452 23432 5727 408 409 2737 2736 57154 9861 6233 8405 9978 7316 1452 10213 8650 51684 2735 64399 22873 5706 25989 5707 5708 339745 5709 83737 5700 5701 5702 3549 5704 64750 5705 5682 5683 5684 5685 50937 91653 5686 132884 2121 5717 23288 5718 2622 5719 84455 2619 11047 156 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 79577 5687 5688 5689 6469 50846 REELIN SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 95%8866376 Reelin signalling pathway 7436 1600 2534 30011 5649 CHYLOMICRON CLEARANCE%REACTOME%R-HSA-8964026.3 Chylomicron clearance 3949 348 338 26119 3990 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME%R-HSA-381340.5 Transcriptional regulation of white adipocyte differentiation 90390 1050 7040 2167 10498 6907 51003 84498 8648 79718 84246 10025 1051 9612 10891 9968 8841 9969 9611 1959 23054 9443 9441 892 9442 7471 54797 55090 5346 5105 9440 80306 8202 51586 10001 9439 948 23097 5465 6837 219541 23389 55588 9412 400569 9967 29079 81857 5468 9477 5469 112950 1019 5970 896 80205 3952 85441 10499 96764 6517 1387 168544 9862 9314 1879 7124 7480 2033 10974 6721 27332 7026 9370 1024 1052 4790 688 6256 51129 6604 4023 9282 DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BRCA1 LOSS OF FUNCTION%REACTOME%R-HSA-9663199.3 Defective DNA double strand break response due to BRCA1 loss of function 672 580 TOXICITY OF BOTULINUM TOXIN TYPE C (BOTC)%REACTOME%R-HSA-5250971.4 Toxicity of botulinum toxin type C (botC) 112755 6616 6804 PHOSPHORYLATION OF CLOCK, ACETYLATION OF BMAL1 (ARNTL) AT TARGET GENE PROMOTERS%REACTOME DATABASE ID RELEASE 95%9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 406 9575 4297 1387 TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME DATABASE ID RELEASE 95%8878171 Transcriptional regulation by RUNX1 84661 3977 11091 5371 640 5929 23309 122809 3276 9739 8850 9070 2625 51412 25 9757 1021 894 896 84333 200845 2099 7122 58508 3562 8970 3559 5196 8331 3558 4297 1378 5781 8337 128312 8334 6595 8335 6597 2033 6599 8370 6598 2624 55766 8968 4602 8341 8342 57678 8347 8348 94239 8784 8345 3013 8340 26053 8013 5275 8338 6601 7161 255626 3674 6603 6602 6605 3021 653604 6604 3018 3017 85236 3014 6886 55170 6688 8349 474382 54145 3065 25942 861 865 595 100506658 8289 55193 10138 5079 10413 8535 4343 6045 192669 23112 648 27327 6015 26523 23466 192670 27161 1912 57690 1911 9861 6929 6233 23429 10398 80012 57332 84733 1437 8312 2811 7316 6714 8085 10213 1493 4331 1022 5706 6938 5707 5708 7057 5709 83737 5700 4773 5701 5702 5704 5705 5682 5683 5684 5685 902 5686 1998 5717 1514 5718 1997 5719 1513 4004 1460 11047 1387 5713 1515 4005 1459 5714 5579 5690 5691 57492 1457 5692 5693 8861 5694 7082 7311 7979 5695 9021 3958 4778 7314 2623 3458 5687 5688 5689 161882 84870 196528 5588 23067 50943 28996 86 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 95%68867 Assembly of the pre-replicative complex 3836 3837 51343 8970 8331 8337 128312 8334 8335 8370 55766 8968 8341 8342 8347 8348 94239 8345 3013 8340 8338 255626 3021 653604 3018 3017 85236 3014 8349 474382 54145 23633 9861 6233 7316 10213 51529 7321 5706 8881 64682 5707 25906 5708 11065 5709 8697 7324 10393 29945 27338 119504 5700 5701 29882 5702 246184 996 5704 51434 5705 51433 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 4172 4173 4174 5687 4175 5688 4176 4171 5689 990 84515 51053 5000 5001 23595 23594 81620 4998 4999 SORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674404.2 Sorafenib-resistant PDGFR mutants 5156 TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME%R-HSA-1299503.3 TWIK related potassium channel (TREK) 3776 54207 50801 ALPHA-DEFENSINS%REACTOME DATABASE ID RELEASE 95%1462054 Alpha-defensins 920 1671 728358 1670 1669 5645 417 5646 1668 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-629594.5 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors 8973 1143 1142 1141 1138 55584 1137 89832 1136 1135 1134 RAS ACTIVATION UPON CA2+ INFLUX THROUGH NMDA RECEPTOR%REACTOME%R-HSA-442982.5 Ras activation upon Ca2+ influx through NMDA receptor 808 88 5923 1742 1741 1740 2906 1739 815 2904 816 5924 4747 2902 817 4893 818 3265 COBALAMIN (CBL) METABOLISM%REACTOME DATABASE ID RELEASE 95%9759218 Cobalamin (Cbl) metabolism 326625 27249 25974 4594 166785 4548 4552 DEFECTIVE HK1 CAUSES HEXOKINASE DEFICIENCY (HK DEFICIENCY)%REACTOME%R-HSA-5619056.4 Defective HK1 causes hexokinase deficiency (HK deficiency) 3098 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 95%72202 Transport of Mature Transcript to Cytoplasm 55339 26097 7919 10482 10921 10250 11338 8563 2733 29894 8683 4116 9775 6430 7884 6432 6431 55110 22794 9785 6427 29107 6426 1977 9939 6429 199746 53981 10212 84248 6428 8189 728343 348995 9883 6396 129401 51692 9688 57122 51213 23225 10189 4927 65109 23165 8021 55746 55706 23636 9631 7175 9972 11097 23279 8086 23511 53371 8480 79023 79902 10762 9295 5903 10569 22916 4686 79228 7307 51362 9984 81608 57187 10898 84324 84271 84321 9877 80145 DEFECTIVE DOLK CAUSES CDG-1M%REACTOME%R-HSA-4755583.4 Defective DOLK causes CDG-1m 22845 DEFECTIVE GALE CAUSES EDG%REACTOME DATABASE ID RELEASE 95%5609977 Defective GALE causes EDG 2582 DEFECTIVE SLC26A3 CAUSES CONGENITAL SECRETORY CHLORIDE DIARRHEA 1 (DIAR1)%REACTOME DATABASE ID RELEASE 95%5619085 Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) 1811 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH3%REACTOME DATABASE ID RELEASE 95%5632927 Defective Mismatch Repair Associated With MSH3 4436 4437 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9632693.5 Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects 1029 1021 1019 RIBOSOME QUALITY CONTROL (RQC) COMPLEX EXTRACTS AND DEGRADES NASCENT PEPTIDE%REACTOME%R-HSA-9954709.2 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 6152 6155 6154 6157 9349 6156 6159 6158 23521 51121 11224 6164 200916 6166 6122 6165 6124 6168 6123 6167 6169 6125 116832 25873 6160 6161 140801 4736 6130 6133 9045 6132 6176 6135 6134 6137 6136 7415 6171 6170 6173 6128 6129 55666 6142 6141 6144 6143 6146 6147 6181 6139 6138 8453 9861 6233 7322 26046 9978 7316 6921 6923 10213 6175 7321 22980 5706 5707 5708 23008 5709 7353 5700 55139 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 5690 5691 5692 5693 5694 9147 7311 7979 5695 7314 5687 5688 5689 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 95%70895 Branched-chain amino acid catabolism 9673 594 36 10295 3028 1892 1629 1738 593 27034 38 11112 64087 586 587 152926 26275 56922 549 3712 4329 GLYCINE DEGRADATION%REACTOME%R-HSA-6783984.3 Glycine degradation 1743 1738 4967 2731 275 2653 92259 CILIUM ASSEMBLY%REACTOME%R-HSA-5617833.7 Cilium Assembly 10383 57787 57545 8100 10382 26005 261734 51098 79600 79809 26123 10013 51134 26160 51259 6608 54806 11127 4735 57728 7846 84902 5566 4867 57539 132320 9657 54903 91147 146057 27077 85302 79867 129880 149371 6753 1262 1260 27241 10576 123016 7277 55763 79738 8729 22948 5310 5311 166379 55212 55770 117177 403 79969 50807 23265 57576 92482 8195 84747 60412 378 84100 54536 2847 6102 8766 6010 582 583 54585 79598 585 27031 192668 1258 9727 10640 11336 3320 8655 5577 23332 22919 5048 55835 56623 5147 200894 54820 80776 22920 1781 1778 9793 9371 140735 5518 9738 23059 28981 3797 150737 51668 55112 9662 11020 7840 57560 11064 56912 6991 22994 64792 22995 92104 7283 83657 10733 200132 80321 203068 83658 26146 55722 89891 1454 112752 1453 255758 55125 51626 9814 90410 79989 11190 80173 115106 79441 95681 9321 1069 3842 54801 983 10142 9702 10540 5347 5108 11116 4218 4751 55142 22897 6950 7203 54930 5116 79959 80184 93323 23354 22981 8481 80254 121441 55755 10806 7532 10121 7531 55559 8636 11258 84131 4957 10694 10575 9742 23322 55081 347240 55764 79659 22832 RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-8868773.5 rRNA processing in the nucleus and cytosol 4839 55720 5394 28987 8780 4809 54881 26168 81875 79159 51388 90459 8568 55759 705 79707 57418 23246 23481 26354 55131 81887 84946 10438 55781 117246 83732 10969 10200 23517 6230 6210 6231 6234 6235 6191 2197 6193 6192 6194 51065 140032 6205 6227 6204 6207 6229 6206 6228 6209 6208 6188 6187 6223 6201 6189 6222 6203 6224 6202 6218 6217 3921 79897 11102 54913 10799 6233 10557 11340 23404 51504 10556 54512 6175 5393 55505 23016 54433 1454 1453 55651 51010 51013 118460 1736 22894 56915 7311 10171 79050 84916 23160 10813 27042 55127 54555 84128 51202 8602 92856 11103 65083 9277 25879 9790 51096 55813 5822 22803 27292 56902 2091 115939 25926 114049 27340 10436 27341 57647 55623 55226 88745 10199 9136 22984 57050 55272 51077 10607 11056 9724 84135 134430 51118 10885 10528 6152 6155 6154 6157 9349 6156 6159 6158 23521 51121 11224 6164 200916 6166 6122 6165 6124 6168 6123 6167 6169 6125 116832 25873 6160 6161 140801 4736 6130 6133 9045 6232 6132 6176 6135 6134 27043 6137 6136 6171 6170 6173 6128 6129 4691 6142 6141 6144 6143 6146 6147 6181 6139 6138 9188 51602 ALPK1 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 95%9645460 ALPK1 signaling pathway 6885 23118 80216 10454 7316 7311 7314 6233 7189 92610 257397 PLC-GAMMA1 SIGNALLING%REACTOME%R-HSA-167021.5 PLC-gamma1 signalling 5335 4803 4914 P38MAPK EVENTS%REACTOME DATABASE ID RELEASE 95%171007 p38MAPK events 5899 5898 7867 6300 5603 1432 5900 4893 3265 5600 9261 SEMAPHORIN INTERACTIONS%REACTOME%R-HSA-373755.3 Semaphorin interactions 57556 4233 7305 971 9475 3326 5879 6093 4628 79784 4629 10507 64218 3984 3985 10570 3688 103910 1809 4637 56896 4627 1400 1808 54209 9723 5362 10371 5365 2242 23396 6237 10398 55558 27289 2932 2909 5062 3320 2064 10154 8482 5063 1020 7094 1072 80031 5788 8851 9037 2534 5361 5364 9855 23365 3672 5058 9826 8829 387 91584 388 23129 389 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 95%428157 Sphingolipid metabolism 84002 53947 57704 285362 9514 2760 79642 56624 25870 2717 4074 340075 6610 6609 2524 91012 410 2523 412 414 415 55627 1455 416 8705 8706 9334 22901 9331 340485 64781 153642 7357 2583 2581 55331 57733 55512 347527 427 388931 125981 8877 112937 3074 3073 204219 79411 80777 411 2720 171546 79152 89944 130367 259230 124976 10715 94103 81537 94101 23683 25865 2531 166929 4363 253782 9218 29095 56848 9217 8611 8612 5587 123099 79603 8613 10558 55304 29906 151742 81849 221 222 6483 8879 5007 6487 5476 142891 10825 29956 30815 165679 9517 8869 8560 2629 4758 4759 9429 5660 7368 339221 SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME%R-HSA-1855231.3 Synthesis of IPs in the ER lumen 9562 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME%R-HSA-434316.8 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 23236 2864 2767 2776 9630 5330 5331 2769 REGORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669929.2 Regorafenib-resistant KIT mutants 3815 INORGANIC ANION EXCHANGE BY SLC26 TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%427601 Inorganic anion exchange by SLC26 transporters 115111 1836 115019 5172 284129 10861 1811 65010 VLDL ASSEMBLY%REACTOME DATABASE ID RELEASE 95%8866423 VLDL assembly 346 5034 338 4547 341 M PHASE%REACTOME%R-HSA-68886.5 M Phase 200014 260334 4926 26003 27436 5566 79643 51652 91782 2801 92421 3837 27243 128866 5577 29082 25978 7341 7329 5901 9861 6233 9738 7316 9662 7840 7514 11064 5578 22994 22995 10213 7283 10733 80321 203068 114791 8021 55722 1454 5706 1453 5707 5708 55125 9814 5709 85378 11190 115106 79441 95681 10426 5700 5701 27175 1069 3842 5702 653784 54801 10142 5704 9702 10540 5705 5682 5108 11116 5683 4751 5684 29922 5685 55142 5686 113457 22897 5717 27229 5718 54930 5719 5116 79959 7280 80184 93323 1460 11047 23354 5713 22981 1459 5714 440145 5579 8481 5690 10844 5691 1457 2010 5692 80254 5693 121441 5694 55755 7311 5695 10806 7532 10121 7314 7531 55559 8636 11258 80097 3930 84131 5687 10376 5688 4957 5689 6418 9133 140609 80086 91754 10783 51807 23592 10381 10383 10382 112714 4001 7846 1104 84790 27183 10051 10592 84617 54892 29781 23310 79648 347733 7277 7278 79861 81027 348995 9883 6396 129401 9688 57122 23225 4927 23165 55746 55706 23636 9631 3320 7175 9972 11097 23279 8086 23511 53371 8480 79023 79902 10762 8815 5903 54908 6232 8655 25909 8379 9183 1063 1062 9184 5925 1060 8970 8331 991 25836 8337 8243 151648 55166 9126 128312 8334 23244 23047 8335 1058 79019 9493 10735 151246 8370 23063 9735 23383 5885 55766 10274 8968 23332 10112 8341 79003 8342 55055 5594 8347 81565 8348 22919 8290 94239 348235 5048 8345 3013 23421 220134 55835 57082 8340 57405 8338 51143 23141 255626 147841 4085 64105 3021 401541 10403 653604 3018 3017 9663 85236 3014 54820 80776 701 8349 54821 474382 378708 1781 54145 23122 1780 79172 1778 81930 55920 84643 3796 64900 9793 91687 57551 79682 23175 5905 1783 5501 83540 80152 2491 5519 332 55143 699 11243 387893 3619 140735 5515 11004 5516 5518 9212 25936 11130 64946 79980 10726 5525 5526 55839 5527 5528 5529 51529 7321 8881 64682 25906 11065 8697 7324 10393 29945 27338 119504 29882 891 246184 983 996 51434 51433 5347 5520 10776 64151 81876 5861 5862 22933 255919 7979 84930 2029 55844 64689 55732 113130 9918 9700 6683 8615 347688 7443 8548 23397 9798 221496 6249 26271 9232 ACTIVATED NTRK2 SIGNALS THROUGH CDK5%REACTOME DATABASE ID RELEASE 95%9032845 Activated NTRK2 signals through CDK5 5879 7074 8851 4915 1020 627 DEFECTIVE SLCO2A1 CAUSES PRIMARY, AUTOSOMAL RECESSIVE HYPERTROPHIC OSTEOARTHROPATHY 2 (PHOAR2)%REACTOME%R-HSA-5619095.4 Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) 6578 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-2979096.6 NOTCH2 Activation and Transmission of Signal to the Nucleus 83464 51107 100996717 1272 100996763 388677 4192 3714 28514 182 7311 7314 6233 9148 54492 4853 7316 142678 57534 102 54567 5663 23385 55851 5664 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND MYOEPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 95%9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 1950 374 7039 MITOTIC SPINDLE CHECKPOINT%REACTOME%R-HSA-69618.4 Mitotic Spindle Checkpoint 348995 6396 57122 55746 23279 79023 79902 5903 54908 6232 8655 25909 8379 9183 1063 1062 9184 1060 991 151648 55166 1058 79019 151246 9735 23332 79003 55055 81565 22919 348235 5048 23421 220134 57082 57405 51143 147841 4085 64105 401541 10403 54820 80776 701 54821 378708 1781 23122 1780 79172 1778 81930 55920 84643 3796 9793 91687 57551 79682 5905 1783 5501 83540 80152 2491 5519 332 55143 699 11243 3619 140735 5515 11004 5516 5518 9212 25936 11130 64946 79980 10726 5525 5526 55839 5527 5528 7514 5529 51529 7321 8881 64682 25906 11065 8697 7324 10393 29945 27338 119504 29882 246184 996 51434 51433 5347 6249 ACYL CHAIN REMODELLING OF PE%REACTOME%R-HSA-1482839.4 Acyl chain remodelling of PE 117245 54979 154141 10162 63874 129642 64600 26279 30814 8605 50640 81579 22925 79887 57110 123745 5321 5920 255189 8398 254531 8399 11145 100137049 5322 283748 5320 5319 50487 REUPTAKE OF GABA%REACTOME%R-HSA-888593.5 Reuptake of GABA 6539 6540 6538 6529 DEFECTIVE SLC5A2 CAUSES RENAL GLUCOSURIA (GLYS1)%REACTOME%R-HSA-5658208.4 Defective SLC5A2 causes renal glucosuria (GLYS1) 6524 DEFECTIVE SLC2A1 CAUSES GLUT1 DEFICIENCY SYNDROME 1 (GLUT1DS1)%REACTOME%R-HSA-5619043.3 Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) 6513 PLASMA LIPOPROTEIN CLEARANCE%REACTOME%R-HSA-8964043.3 Plasma lipoprotein clearance 163 23491 57552 8435 335 4864 6646 3990 1175 1173 3949 7376 10062 3069 51599 55911 3988 341 29116 346 348 7311 7314 6233 338 26119 1213 1211 7436 7316 81693 255738 10577 8029 160 161 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 95%77348 Beta oxidation of octanoyl-CoA to hexanoyl-CoA 3030 1892 34 3033 3032 SIGNALING BY CYTOSOLIC PDGFRA AND PDGFRB FUSION PROTEINS%REACTOME%R-HSA-9673766.2 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins 81608 6801 57599 MITOCHONDRIAL PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 95%1268020 Mitochondrial protein import 100272147 516 10651 5009 6901 10531 400916 150274 56942 54927 92609 197257 29928 51142 498 51025 134266 79145 27235 9804 54543 3421 29090 10245 26519 291 26515 9868 293 26517 51287 8604 10452 50 3313 90639 1537 4580 10063 26521 9512 10469 23203 26520 100188893 80273 100287932 7416 1678 401505 84269 1431 56993 25813 617 131474 3329 131118 388753 10165 10440 506 4714 2671 2395 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%R-HSA-349425.4 Autodegradation of the E3 ubiquitin ligase COP1 5706 5707 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 472 5719 11047 5713 7157 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 9861 6233 5687 5688 5689 7316 10213 64326 DISEASES OF IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 95%5260271 Diseases of Immune System 2244 51135 2266 7100 114609 3551 5970 4615 81793 2243 6279 7187 148022 10333 6271 8517 4792 81622 7098 3146 23643 6280 4790 7097 7096 7099 948 695 4791 51284 929 1147 AUTOPHAGY%REACTOME DATABASE ID RELEASE 95%9612973 Autophagy 8100 10013 55048 89853 137492 51271 51160 155382 93343 7251 79720 1080 29110 9804 10533 65018 4077 81631 5830 7405 7335 7332 79643 51652 84749 91782 3320 92421 8655 22863 7415 7334 7417 27243 7416 7419 128866 29082 55062 1915 25978 30849 51143 200894 5289 1781 1780 1778 8878 3326 5562 5563 7248 1783 10226 5564 5565 389541 28956 115201 55054 123 57521 51001 89849 55004 8649 285973 56270 51422 55626 10670 6009 9776 23710 84971 440738 140735 5571 9821 60673 64121 64223 11152 84938 54543 83734 153129 7323 64422 6233 7322 23192 2034 9927 26100 11345 53632 2475 55669 7249 3297 58528 10542 3312 10325 7316 9868 8678 8897 10452 11337 10133 100188893 472 5116 5071 401505 1460 1459 56993 1457 7311 7314 3043 9140 8408 9474 79065 84557 6035 2670 139341 1068 11315 3920 64419 DEFECTIVE AVP DOES NOT BIND AVPR1A,B AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-5619099.5 Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) 553 551 552 IKBKG DEFICIENCY CAUSES ANHIDROTIC ECTODERMAL DYSPLASIA WITH IMMUNODEFICIENCY (EDA-ID) (VIA TLR)%REACTOME%R-HSA-5603027.3 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) 8517 3551 1147 INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 95%499943 Interconversion of nucleotide di- and triphosphates 7298 7296 2987 51727 4832 4833 7295 56474 203 6240 204 205 1841 50484 4830 2745 102157402 1503 4831 79077 122481 6241 158067 221264 26289 1635 25961 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME DATABASE ID RELEASE 95%446199 Synthesis of dolichyl-phosphate 79947 116150 4597 22845 57171 207063 79644 DEFECTIVE ALG1 CAUSES CDG-1K%REACTOME DATABASE ID RELEASE 95%4549380 Defective ALG1 causes CDG-1k 56052 SIGNALING BY PDGFRA EXTRACELLULAR DOMAIN MUTANTS%REACTOME%R-HSA-9673770.2 Signaling by PDGFRA extracellular domain mutants 6774 5295 5296 6772 5156 6654 4893 5290 5291 3265 BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME%R-HSA-9023661.2 Biosynthesis of E-series 18(R)-resolvins 246 4048 240 ONCOGENIC MAPK SIGNALING%REACTOME%R-HSA-6802957.9 Oncogenic MAPK signaling 55750 9061 5894 5906 5908 55109 161742 27044 4763 57670 22808 399473 11221 8805 56829 5501 408 9715 409 200734 23164 4296 8546 57085 11044 54845 9444 3845 808 1852 10533 1850 10827 8036 8087 815 5500 6714 816 817 8315 818 5245 2335 3717 673 8826 22906 2244 2266 7414 8844 10256 54518 22866 4140 7450 5037 2243 7094 7529 1445 369 10142 283455 4893 4000 5594 10018 5595 3690 3674 1185 80824 5604 5605 1849 1848 80853 3265 EPIGENETIC REGULATION BY WDR5-CONTAINING HISTONE MODIFYING COMPLEXES%REACTOME DATABASE ID RELEASE 95%9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 84661 11091 5929 10025 9968 9969 892 10474 9739 10001 8850 9070 25 3054 11168 29079 5469 9757 63924 58508 5925 8970 8331 4297 2648 8337 128312 9862 8334 8335 2033 8370 55766 10445 8968 8341 8342 57678 8347 8348 51230 94239 8345 3013 8340 8338 255626 2180 6256 3021 653604 3018 3017 85236 3014 8349 90390 60481 474382 84649 6319 1050 54145 2167 11343 6907 3991 51003 8648 79718 23175 84246 9612 10891 8841 55683 9611 55689 4221 729359 123 23054 9443 22976 2874 9442 5166 5346 54934 9440 8202 133522 948 9439 84962 1810 51562 26993 29915 79447 8085 259282 2494 57325 9477 84148 51105 22822 1020 80335 6871 57104 284058 8800 10499 55617 7069 91272 1387 9370 8473 1024 79611 26009 23411 7403 112869 51129 10555 23067 30827 4023 9282 TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-8864260.5 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 2064 4435 1956 10370 7528 4869 163732 1026 4839 2099 29028 10765 1081 1387 4609 7341 7022 2033 79047 7021 83741 348 51741 7329 339488 7913 7020 3329 5308 284252 4605 3815 94115 7039 8089 7422 CHYLOMICRON ASSEMBLY%REACTOME%R-HSA-8963888.2 Chylomicron assembly 51128 348 345 335 336 337 5034 338 4547 344 DEFECTIVE COFACTOR FUNCTION OF FVIIIA VARIANT%REACTOME%R-HSA-9672396.2 Defective cofactor function of FVIIIa variant 2158 2157 2159 VEGFA-VEGFR2 PATHWAY%REACTOME DATABASE ID RELEASE 95%4420097 VEGFA-VEGFR2 Pathway 10006 9475 5566 57761 5567 1499 5568 10810 9844 5879 6093 3710 4846 5295 7867 5296 5290 5291 63916 5170 55615 558 25759 6461 6300 64223 808 5603 5580 8877 1398 9261 2475 1793 3315 5829 9047 5578 3708 1003 3709 3791 5062 253260 4690 1536 3320 1535 5335 10458 207 55845 5063 4688 4689 2185 9564 5590 3728 2534 8936 1432 5921 4893 10787 5579 10152 117145 998 10768 857 10451 7410 5600 3690 3071 1495 3685 208 5058 10000 8440 10163 1500 5747 7409 23191 387 653361 79109 26999 3265 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME%R-HSA-5693532.5 DNA Double-Strand Break Repair 51588 7157 29086 2547 7520 3981 7518 51720 25 51567 79840 55775 55183 10721 27343 64421 27434 51548 142 10714 5424 5425 57804 5981 2072 63967 56655 2070 5536 7515 7334 322 2140 7336 8970 2139 2138 5426 5427 128312 79184 3980 51426 10038 8370 2067 54107 8341 8342 8347 8290 8348 6047 5591 8345 8340 255626 3018 3017 85236 3014 23030 8349 54145 348654 146956 197342 84464 9656 23514 80198 1017 9682 79008 5599 2237 51035 8924 7341 22976 7329 6233 6613 8467 7316 11200 8314 165918 7468 7158 7486 5982 5883 5884 5983 116028 3364 472 5429 10635 54962 9025 672 151987 675 5893 84126 5531 1111 8914 83990 144715 3838 63979 83695 51750 5810 7516 10111 5932 7517 7311 7979 4361 5111 7314 7156 5890 9156 5892 55732 84142 4683 11073 9031 9577 580 10524 641 1763 545 6117 5984 890 5985 6119 8900 79728 5888 6118 80010 5889 METABOLISM OF COFACTORS%REACTOME%R-HSA-8978934.6 Metabolism of cofactors 56910 3320 207 51805 57017 57107 56997 23590 10229 84842 79934 51004 51117 84274 3417 4846 5593 5805 2644 2643 6697 808 27235 1719 48 SPECIFICATION OF PRIMORDIAL GERM CELLS%REACTOME%R-HSA-9827857.2 Specification of primordial germ cells 8320 7022 7852 9139 54790 342977 652 64321 639 5460 79923 10630 PORPHYRIN METABOLISM%REACTOME%R-HSA-189445.3 Porphyrin metabolism 213 2168 1352 1371 28234 3145 3163 212 5498 2938 211 644 645 2235 7389 7390 10599 3162 54658 1244 54657 9429 1355 210 4363 DENGUE VIRUS GENOME TRANSLATION AND REPLICATION%REACTOME%R-HSA-9918487.1 Dengue Virus Genome Translation and Replication 4904 23478 60559 3839 5611 28972 402569 2923 3840 90701 3841 1650 335 7431 100128731 6185 7991 6184 3309 10313 9775 58505 201595 3069 821 5593 746 1603 3703 7341 6238 1977 10525 7329 6233 81631 3312 7316 7514 3836 8974 54431 283208 51726 5033 10527 7353 1981 8813 64225 689 3837 811 4666 8818 22937 25777 9532 1982 8672 7415 317649 55666 3838 1974 2194 1973 7311 7314 26986 54464 10965 3304 54344 10294 4836 5034 9789 84061 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190372 FGFR3c ligand binding and activation 8823 8074 8817 2249 26281 2247 2246 2591 2254 ABACAVIR METABOLISM%REACTOME%R-HSA-2161541.6 Abacavir metabolism 22978 5105 124 161823 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%R-HSA-879415.2 Advanced glycosylation endproduct receptor signaling 3146 1650 3958 5594 351 177 5595 830 829 5589 6285 6288 6283 ESSENTIAL PENTOSURIA%REACTOME%R-HSA-5662853.4 Essential pentosuria 51181 NUCLEOTIDE EXCISION REPAIR%REACTOME%R-HSA-5696398.4 Nucleotide Excision Repair 60 125476 2873 51138 9318 10450 54891 91603 7874 1643 27339 8607 1161 9716 7528 142 10714 5424 5425 8451 57804 5981 8533 29844 3978 2073 2072 64708 56655 85015 7515 7334 9557 7336 10987 10980 5426 5427 3980 51426 50813 283899 10038 83444 2067 10920 1642 10445 54107 7507 7508 10401 7341 8554 7329 6233 57654 9978 6612 6613 7316 54778 93973 5440 5441 4331 1022 2071 2966 2965 2068 5434 5435 5436 5437 1069 5438 5439 2968 2967 8178 404672 5430 5431 5432 5433 5982 902 5983 6917 57461 7311 2074 5111 7314 79913 54617 56949 6117 5984 5985 6119 5886 6118 4798 5887 86 REGULATION OF PD-L1(CD274) TRANSCRIPTION%REACTOME%R-HSA-9909649.2 Regulation of PD-L1(CD274) transcription 474382 2146 84661 54145 11091 83439 23476 1499 51176 5928 7004 5929 6932 6934 7003 7005 3727 2354 6772 467 10413 4609 5931 4613 23512 2034 9070 3091 8726 4791 3659 5970 58508 8970 8331 4780 25937 4297 8337 8463 128312 1387 8334 8335 2033 8370 55766 8968 8341 8342 4790 8347 8348 94239 8345 2353 3013 8340 8338 255626 6774 3021 653604 3725 3018 3017 85236 3014 8349 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 95%71240 Tryptophan catabolism 51166 3620 6520 883 169355 8140 125061 8942 130013 120103 56267 6999 8564 23498 PENTOSE PHOSPHATE PATHWAY DISEASE%REACTOME DATABASE ID RELEASE 95%6791465 Pentose phosphate pathway disease 22934 6888 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME%R-HSA-162710.6 Synthesis of glycosylphosphatidylinositol (GPI) 84992 80235 9487 55650 9488 284098 5277 5279 8818 5283 54965 51227 5281 93183 84720 54872 23556 DEFECTIVE EXT2 CAUSES EXOSTOSES 2%REACTOME%R-HSA-3656237.5 Defective EXT2 causes exostoses 2 6382 2239 2719 2817 375790 2131 3339 6383 221914 9672 10082 6385 2262 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%R-HSA-3000171.6 Non-integrin membrane-ECM interactions 3693 3371 7040 375790 1756 2247 6645 87 780 51399 3339 7402 4921 6383 6443 3673 3688 6442 9672 6445 6444 6385 8573 6382 9378 8082 54221 7276 5578 59277 3913 3914 3915 10319 3918 284217 3908 7057 3909 7448 3910 3911 3912 137868 5154 1605 1821 1838 1837 3691 3690 5155 3655 8910 3685 6641 6640 DEFECTIVE CYP27B1 CAUSES VDDR1B%REACTOME DATABASE ID RELEASE 95%5579027 Defective CYP27B1 causes VDDR1B 120227 FOXO-MEDIATED TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-HSA-9617828.2 FOXO-mediated transcription of cell cycle genes 4087 4088 57060 5934 4089 2660 857 2290 4303 1026 694 1027 901 2309 2308 1647 9314 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME%R-HSA-6803204.3 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 51499 5366 665 94241 8626 637 63970 7159 84883 55240 147923 23368 7161 581 27113 472 10650 1387 27166 7157 INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME%R-HSA-8854521.3 Interaction between PHLDA1 and AURKA 22822 6790 REPLICATION OF THE SARS-COV-2 GENOME%REACTOME%R-HSA-9694686.7 Replication of the SARS-CoV-2 genome 85437 5925 7428 1655 SPHINGOLIPID CATABOLISM%REACTOME%R-HSA-9845614.3 Sphingolipid catabolism 55331 221 8613 222 8879 125981 8611 130367 8612 340485 81537 DEFECTIVE SLC4A4 CAUSES RENAL TUBULAR ACIDOSIS, PROXIMAL, WITH OCULAR ABNORMALITIES AND MENTAL RETARDATION (PRTA-OA)%REACTOME%R-HSA-5619054.4 Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) 8671 DISEASES OF GLYCOSYLATION%REACTOME DATABASE ID RELEASE 95%3781865 Diseases of glycosylation 1836 56667 1462 113189 3074 3073 63827 1634 2720 633 1464 1463 10675 11093 2683 145173 57188 2591 143662 79695 10417 118430 11041 10418 9215 170689 29954 171019 54437 9510 9037 4582 5199 4583 7058 4584 4585 10585 4586 55624 200958 1605 157869 727897 29071 9507 140766 80070 2592 9508 9509 10071 94025 339366 9469 221981 79875 81794 140453 55901 4588 4589 81792 4851 283463 4853 9719 4854 11285 56999 4855 126792 56913 394263 11173 11096 11095 11174 80731 170690 54507 170692 7841 92949 170691 9060 4060 26229 375790 4247 2131 2331 130589 176 3339 6383 221914 11253 9672 10082 6385 2262 6382 2239 2719 2817 2584 2582 56052 440138 79053 22845 6487 5476 10020 79087 7057 11081 2673 8813 4969 85365 8818 4166 29929 4351 4958 10195 5549 1798 79796 22856 91869 116150 5373 3955 199857 54344 79868 9526 79947 4758 79644 5236 BCKDH SYNTHESIZES BCAA-COA FROM KIC, KMVA, KIV%REACTOME DATABASE ID RELEASE 95%9859138 BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV 594 1629 1738 593 ENTEROBACTERIAL FACTORS ANTAGONIZE HOST DEFENSE%REACTOME DATABASE ID RELEASE 95%9956593 Enterobacterial factors antagonize host defense 2633 7316 115361 7311 7314 163351 808 2634 837 7322 6233 DRUG RESISTANCE OF FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702506 Drug resistance of FLT3 mutants 2322 HCN CHANNELS%REACTOME%R-HSA-1296061.5 HCN channels 348980 57657 610 10021 SIGNALING BY NOTCH2%REACTOME%R-HSA-1980145.4 Signaling by NOTCH2 83464 51107 100996717 1272 100996763 388677 3002 4192 3714 2208 9794 3516 2033 28514 182 7311 7314 84441 6233 3280 9148 10046 54492 4853 7316 142678 388585 57534 102 54567 5663 23385 55851 5664 55534 CHROMATIN MODIFYING ENZYMES%REACTOME DATABASE ID RELEASE 95%3247509 Chromatin modifying enzymes 84661 23186 11091 25855 5926 5928 10362 5929 51317 5931 9070 1108 57504 9112 63976 83933 5970 10765 58508 5978 6187 1386 22992 6601 51780 6603 6602 84864 6605 8242 5253 6604 23210 23133 8284 55693 23030 84159 80853 84678 27154 7404 57459 3065 595 79813 10419 6880 6883 10856 56950 55869 7994 56979 7468 93624 80314 8473 317772 4790 85235 64426 196528 86 2146 23326 84289 60 10498 57634 6881 7862 10474 3276 221613 9739 8850 8295 11240 92815 51412 2122 8969 8607 8726 440689 3054 23774 9757 6314 1019 53615 8970 8331 4297 2648 8337 128312 8334 6595 8335 64769 6597 2033 6599 8370 6598 55766 10445 8968 23135 8341 8342 8347 8348 51230 94239 8345 3013 8340 29943 84444 27097 8338 5927 55578 255626 9767 9643 54014 353238 653604 64754 3018 117143 3017 11143 85236 10196 6944 3014 54496 8464 79084 55929 55170 55352 5077 8349 55250 55257 474382 10629 26610 23587 55140 54815 83852 54859 79918 23028 9682 51111 23569 55167 6907 10933 64324 8648 23338 10943 56943 79718 9913 51147 51702 8289 55870 55193 23522 9612 10919 54556 56970 8841 84193 55683 79960 9611 55689 10902 79723 221656 29072 9869 339287 84787 1107 2874 8520 80854 387893 54904 8518 54934 3066 55818 23512 1810 51562 79685 8089 6839 8085 4791 9219 3717 79595 57325 23081 84148 10284 6871 284058 10499 55729 9575 8819 1387 121536 57492 26009 10524 1788 7403 112869 51742 23067 DEFECTIVE SLC34A2 CAUSES PALM%REACTOME DATABASE ID RELEASE 95%5687583 Defective SLC34A2 causes PALM 10568 HEME ASSIMILATION%REACTOME DATABASE ID RELEASE 95%9927020 Heme assimilation 3040 3043 RRNA MODIFICATION IN THE MITOCHONDRION%REACTOME%R-HSA-6793080.7 rRNA modification in the mitochondrion 29960 81554 51335 84881 51106 22868 285367 26995 387338 55178 130916 51001 79922 TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 95%5668541 TNFR2 non-canonical NF-kB pathway 8771 128178 8995 970 1896 10913 4049 10673 939 8740 8600 8744 4982 7293 7292 3604 8792 4055 60401 8742 23495 4050 943 115650 944 51330 9966 959 8718 608 9020 7187 7186 5971 7133 356 7132 9861 6233 7316 10213 4791 8741 8945 5706 5707 5708 5709 329 5700 5701 5702 5704 5705 5682 23291 5683 5684 5685 330 5686 5717 5718 5719 11047 7124 5713 5714 5690 8764 9039 5691 5692 5693 5694 7311 7979 5695 7314 9040 8454 8784 5687 5688 5689 6500 1147 TRANSPORT OF FATTY ACIDS%REACTOME%R-HSA-804914.3 Transport of fatty acids 376497 347 28965 389812 10999 3933 286256 CELLULAR RESPONSE TO MITOCHONDRIAL STRESS%REACTOME%R-HSA-9840373.2 Cellular response to mitochondrial stress 8894 9812 11331 30968 115209 10730 1965 27102 1968 RESPIRATORY SYNCYTIAL VIRUS INFECTION PATHWAY%REACTOME%R-HSA-9820952.2 Respiratory Syncytial Virus Infection Pathway 23478 7706 60559 5045 28972 90701 3454 10025 9968 9969 892 3661 7097 10001 929 29079 3320 5469 1956 5499 64135 3837 5868 4691 10134 9862 2033 23643 8341 7099 3480 90390 375790 3326 51003 3339 84246 6383 221914 5501 9672 10082 6385 4131 3442 9443 3441 9441 2262 6382 25820 3440 9442 54797 2239 5610 10332 2719 7098 55090 3452 2817 3451 9440 80306 3449 3448 51586 3447 6233 4939 3446 9439 3445 57506 23097 9978 3444 9246 3443 6837 219541 3312 23389 7316 6921 3456 55588 6923 7514 5500 5869 9636 9412 1524 400569 30835 8678 5878 81857 3716 9477 112950 7297 1460 1387 1459 10333 1457 1024 8065 7311 23586 7314 51191 51284 9282 9789 6773 DEFECTIVE AMN CAUSES MGA1%REACTOME DATABASE ID RELEASE 95%3359462 Defective AMN causes MGA1 2694 81693 8029 LEISHMANIA PARASITE GROWTH AND SURVIVAL%REACTOME DATABASE ID RELEASE 95%9664433 Leishmania parasite growth and survival 113 114 115 5045 107 108 55970 109 196883 5566 5567 5568 10800 2268 54331 6868 79651 3710 136 59345 9332 2781 4627 346562 2212 2782 64174 808 10681 4067 2778 2771 2770 3708 3709 2773 2678 5335 2687 10769 917 2209 3586 2793 2792 5573 2534 6850 1432 5575 2791 3055 5576 5577 2790 5613 2214 2788 10768 2787 2786 2785 1800 2784 2783 3569 51764 57105 7525 94235 5336 111 112 FLT3 MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 95%9702509 FLT3 mutants bind TKIs 2322 RESISTANCE OF ERBB2 KD MUTANTS TO AEE788%REACTOME DATABASE ID RELEASE 95%9665250 Resistance of ERBB2 KD mutants to AEE788 11140 3320 2064 55914 HIV TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 95%167161 HIV Transcription Initiation 2071 2966 2965 83860 2963 2962 8148 2068 5434 6872 5435 5436 51616 6874 5437 6873 5438 5439 2968 2967 404672 6881 5430 5431 138474 54457 5432 5433 6908 902 6880 6883 2961 2960 6882 6884 2959 2958 129685 2957 6875 6878 6877 6879 5440 5441 4331 1022 COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME%R-HSA-6814122.3 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding 8786 55970 9628 5082 54331 2767 908 6950 59345 7203 2793 10574 2792 2791 10576 2769 1460 2790 1459 22948 2788 2782 1457 2787 2786 2785 2776 2784 2783 51764 10681 10693 10694 10575 9630 94235 6000 8787 ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME%R-HSA-451307.5 Activation of Na-permeable kainate receptors 2898 2897 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 95%5696397 Gap-filling DNA repair synthesis and ligation in GG-NER 10714 5424 5425 5981 57804 3978 5982 56655 5983 7515 5426 5427 3980 51426 54107 7311 5111 7314 6233 6117 7316 5984 5985 6119 6118 NUCLEAR SIGNALING BY ERBB4%REACTOME%R-HSA-1251985.7 Nuclear signaling by ERBB4 83464 51107 6776 5241 6678 2099 23118 6868 9611 10413 10608 348 51741 6387 9542 10718 145957 11033 3084 3925 685 2069 2670 1447 6714 1839 5663 6285 23385 55851 5664 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 95%1280218 Adaptive Immune System 91445 84661 6048 11091 91319 10956 5928 5929 5931 930 975 9070 23308 5970 58508 7334 7336 10987 11119 11118 696 56244 7498 11120 10385 153579 10384 79908 55860 51164 1508 830 7409 10671 1639 93661 84516 8651 3551 4615 5879 27180 945 55615 8453 7323 7322 2034 9978 3091 3689 6921 6923 54778 7428 5795 1075 5788 6402 1460 26272 1459 5579 1457 10120 7532 26234 126014 6468 26190 26270 11314 7525 5588 55294 7305 8778 10517 84261 11026 26224 54461 6396 80196 3903 10288 253260 1512 8655 1062 991 8463 998 10273 5493 51143 1147 1781 1780 1778 81930 84643 3796 1783 3688 5519 51466 140735 5515 57154 11004 5516 5518 5525 5526 5527 5528 5529 4791 29126 2244 2266 9402 3123 3122 3120 55740 2243 3119 3937 3118 1445 3117 3115 3113 915 27040 916 917 9398 2533 3127 3126 3125 3702 2534 6850 3932 2214 8454 1213 1211 51128 142678 6500 5336 160 30011 161 163 29760 23108 973 6494 5894 5906 974 5908 5909 5566 5133 23476 5567 11069 5568 10411 10235 10125 1175 1173 3727 1785 2354 154881 7320 7325 6477 131405 22872 221687 7220 79654 51088 9616 90678 7318 7317 56658 7319 10533 22888 3093 9870 9871 64167 9632 7335 150726 10425 64718 10427 118424 23295 55336 7408 7327 7326 197131 9867 8945 7328 10422 54926 8673 65264 9520 114609 10193 10075 93611 127247 401036 79791 4775 29927 55585 57520 89910 811 51665 7337 51666 26091 55905 2209 63893 22863 142686 57531 142685 55236 51676 5720 142689 223082 91694 4772 10293 9666 5534 6271 51320 80204 10616 57542 51444 11146 135892 55008 9554 5530 6047 6049 5532 23376 23014 57674 143279 25793 84231 11275 50489 9320 55819 64410 90025 222235 84937 140691 51465 54850 140456 140458 90933 140459 2923 90135 25897 9690 146330 140460 140461 3107 140462 3106 255488 114088 54620 23352 868 8916 5562 115290 7704 5563 55958 8139 390594 5564 127544 5565 55284 84961 27246 9020 997 10892 8924 84433 122769 8925 64320 51422 9354 3134 3133 81559 55175 5571 84708 7174 64223 27252 55176 51130 642 2280 51132 55824 26046 9902 53632 2475 9903 6890 9246 4591 25847 6892 8773 6891 158506 92369 55182 126433 26259 64219 23304 7064 9341 201456 5062 144699 3135 899 1536 84861 92912 10477 1535 4360 5696 26268 55070 7879 90293 84727 4688 92591 4689 26263 10802 1520 26267 10484 10540 53339 10489 4751 285231 89890 4012 9820 26235 26118 79176 26232 55521 5698 5699 84085 4008 10333 51725 9039 26249 25831 8065 84078 29127 55658 10121 140739 51619 9040 148581 11258 79876 79754 84541 9730 154214 51191 151636 80176 5058 51752 9604 136371 10324 653361 124599 54210 100132285 9436 342510 81035 22914 7454 25780 118788 4794 933 8405 5966 10331 3824 27071 80380 5063 26191 9493 10112 3685 8915 3693 4793 23118 1326 23512 948 2932 30835 4780 1387 151888 8764 5777 2353 10000 3725 1759 3710 959 80228 84876 26052 6786 7332 3708 3709 929 3659 5641 114876 3146 23643 7099 84061 80028 1525 23194 120425 1650 4267 100128731 6185 7991 972 6184 58505 201595 821 746 1603 3703 6478 8767 4067 3635 695 146850 5294 23533 8678 375 3716 63891 5478 5728 64750 5721 829 5071 89122 10768 4792 5293 6885 7189 57630 832 941 942 9817 50852 4690 7415 5781 4893 7535 8503 117145 8517 30849 1509 208 24137 26153 5289 6654 3265 22920 57761 5295 5296 9371 5290 5291 5170 808 3797 3832 3835 285643 51529 7321 8881 64682 11065 8697 7324 10393 29945 27338 29882 246184 996 51434 51433 23291 56992 7979 6712 6810 6279 3309 54209 6280 7097 7096 920 3695 3386 3385 3384 3383 595 83439 1499 51176 6932 6934 7087 467 7412 10413 4609 4343 192669 23112 27327 999 26523 4613 192670 27161 57690 9861 6233 7316 10213 1493 23480 7534 5706 5707 5708 5709 3683 207 4773 5700 5701 5702 7529 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 3676 11047 5713 5714 5690 5691 5692 5693 5694 10952 7311 5695 7314 4790 909 5687 56253 56654 5688 5817 5819 5689 89858 910 911 912 4068 3803 3804 3805 3806 79109 374383 925 10666 3802 285852 23327 23547 29121 10990 718 2146 4345 10871 10870 3811 3812 27181 353514 11127 114836 117157 8452 2213 946 3820 3821 340205 640 10219 10053 8907 146894 8905 57823 10859 130340 11024 1174 11027 162 135250 131450 164 6772 9437 5930 3105 940 259197 567 79168 926 29992 29990 10225 89790 22954 4277 114132 51348 11126 11006 339390 100131439 9976 100507436 80329 6737 79465 3904 79865 27036 146722 6614 196500 8519 23608 4734 8726 5335 1019 200845 51343 6502 8970 25937 8331 4297 8337 128312 8334 8335 2033 10437 8370 55766 8968 8341 8342 8347 8348 94239 8345 3013 8340 1510 1519 8722 8338 83547 3112 255626 3111 6774 3902 3021 84676 3109 653604 3108 3018 3017 85236 3014 8349 474382 6456 54145 11059 7004 7003 7005 29116 3798 3799 64837 114907 89953 147700 5476 3831 83737 1514 1513 27248 79139 1515 51009 6400 9021 11160 10613 DEFECTIVE ABCB11 CAUSES PFIC2 AND BRIC2%REACTOME%R-HSA-5678520.4 Defective ABCB11 causes PFIC2 and BRIC2 8647 ERK1 ERK2 PATHWAY%REACTOME DATABASE ID RELEASE 95%5684996 ERK1 ERK2 pathway 6708 6710 5623 5894 6712 5906 5908 64096 10125 5786 5593 25759 6300 53358 5900 57731 8682 8437 2335 221002 51332 7010 284 5863 152559 2339 51104 10156 9693 6709 22821 115727 1844 1843 153090 4902 1847 54756 9048 8831 84292 57139 5778 81926 3562 64926 3559 58489 5156 3558 5922 5979 23463 3569 3815 1839 1849 1848 1846 4233 51125 5924 28956 51114 8649 9986 9861 6233 9978 7316 10213 5706 3716 5707 5708 2064 5709 5700 7297 5701 23179 5702 7529 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 5690 5691 5692 5693 5694 84078 7311 5695 7314 5687 5688 5689 80824 5588 402 8452 161742 4763 22808 399473 11221 408 409 200734 4296 25780 1852 1850 8036 5923 3563 3560 6711 1439 1438 3568 3567 2342 8826 1950 1956 377630 5536 5921 5781 4893 27006 5159 8660 9542 10718 145957 5594 5595 10818 3570 3690 4684 3674 8817 5604 26281 5147 5605 9965 6654 2254 3265 2252 2251 8074 2249 2248 2247 2246 2323 9462 2322 152831 8823 5295 5501 5296 6464 2264 5519 5290 5291 2255 3667 5515 5516 3845 808 5518 88 3084 1742 1741 1437 1740 2906 5525 5526 1739 815 5527 2904 5528 5500 5529 6714 816 4747 2902 817 8315 818 5245 3717 3561 673 2244 2266 7414 8844 10256 54518 22866 4140 7450 5037 2243 10048 7094 983 1445 369 283455 10817 374 2534 598 3082 10434 7979 7039 685 5155 5774 255324 2069 5747 2668 2676 2675 3718 2674 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9630791.4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 1029 1019 NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME DATABASE ID RELEASE 95%5675221 Negative regulation of MAPK pathway 673 152559 8844 5894 4140 5037 1844 1843 7529 369 1847 11221 5778 5536 5519 4893 5515 7311 5516 6300 7314 5518 5594 1852 5595 1850 6233 5774 5525 5526 5527 7316 5528 5529 80824 5604 5605 1849 1848 1846 8315 3265 REGULATION OF NF-KAPPA B SIGNALING%REACTOME%R-HSA-9758274.2 Regulation of NF-kappa B signaling 8517 9684 7311 7314 3551 79671 121457 6233 9097 841 7316 11274 1147 84166 7186 7189 7157 MRNA POLYADENYLATION%REACTOME%R-HSA-9770562.1 mRNA Polyadenylation 4904 10914 10915 10236 11325 55749 6434 11338 29894 27316 3183 6430 79869 5930 6432 6431 1660 8175 23524 1655 6427 6426 6429 6428 8189 27336 1665 84991 3181 3188 3187 3185 3184 55660 2521 3192 3191 3190 5499 9295 83443 7307 51639 3178 81608 10898 23283 10772 55339 64852 1479 1478 1477 10992 9879 8683 11051 5725 10523 10291 10978 199746 53981 6233 58517 10181 8106 51692 7316 57794 5500 5440 4670 5441 64895 51585 5511 2963 5514 2962 22826 22827 5434 5435 5436 5437 5438 8241 5439 5093 5094 22916 5430 51593 4686 5431 23350 5432 5433 10285 9584 6632 6631 10929 84844 51362 6625 6627 6626 6629 7311 135295 6628 7314 220988 10262 10946 23450 23451 6634 6633 6636 6635 6638 6637 22803 NILOTINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 95%9669926 Nilotinib-resistant KIT mutants 3815 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME%R-HSA-163765.6 ChREBP activates metabolic gene expression 31 2194 32 10554 47 51085 6945 EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-HSA-3928665.5 EPH-ephrin mediated repulsion of cells 2048 163 83464 1946 2047 51107 1945 1949 1969 1948 1944 1947 4318 1759 284656 2045 2044 5879 2043 1175 2042 1173 2041 8218 7074 4313 2046 2534 1212 10451 7410 1213 1211 4067 7525 102 1943 5663 2051 23385 160 1942 2050 285220 161 55851 5664 2049 DEFECTIVE NTHL1 SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 95%9630222 Defective NTHL1 substrate binding 4913 HCMV EARLY EVENTS%REACTOME%R-HSA-9609690.2 HCMV Early Events 2146 1781 1780 1778 6907 5371 5928 79718 1783 9612 3688 8841 9611 2874 5931 140735 221613 23512 348995 10155 10951 9883 6396 129401 92815 9688 8969 57122 8726 23225 440689 4927 23165 8021 55746 55706 23636 9631 7175 9972 11097 23279 1956 8086 23511 53371 8480 79023 79902 10762 5903 8655 1616 8970 8331 8337 128312 8334 8335 8370 8968 317772 8341 8342 4790 8347 85235 8348 8345 3013 8340 8338 51143 2002 255626 653604 3018 3017 85236 8349 DEFECTIVE MMAA CAUSES MMA, CBLA TYPE%REACTOME%R-HSA-3359475.4 Defective MMAA causes MMA, cblA type 4594 166785 IFNG SIGNALING ACTIVATES MAPKS%REACTOME DATABASE ID RELEASE 95%9732724 IFNG signaling activates MAPKs 3716 3459 5894 3460 5594 5595 3458 3717 DEFECTIVE RFT1 CAUSES CDG-1N%REACTOME DATABASE ID RELEASE 95%4570571 Defective RFT1 causes CDG-1n 91869 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-210500.6 Glutamate Neurotransmitter Release Cycle 6506 8541 6505 8497 6507 8499 27165 6844 22999 8500 2744 10497 10815 57030 5864 6616 6857 10550 6512 54407 6511 9256 6804 DEFECTIVE GAMMA-CARBOXYLATION OF F9%REACTOME%R-HSA-9673240.2 Defective gamma-carboxylation of F9 2158 2677 LXRS REGULATE GENE EXPRESSION LINKED TO GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 95%9632974 LXRs regulate gene expression linked to gluconeogenesis 6256 5105 10062 8204 6257 PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME DATABASE ID RELEASE 95%8850843 Phosphate bond hydrolysis by NTPDase proteins 57089 9583 377841 954 953 955 956 957 RA BIOSYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 95%5365859 RA biosynthesis pathway 112724 10170 9249 8854 64577 10901 1381 57665 216 8608 51109 8644 157506 5959 220 124 126 1592 127 195814 340665 56603 INTESTINAL ABSORPTION%REACTOME DATABASE ID RELEASE 95%8963676 Intestinal absorption 6523 6518 6248 6514 NGF-INDEPENDANT TRKA ACTIVATION%REACTOME DATABASE ID RELEASE 95%187024 NGF-independant TRKA activation 116 117 135 4915 4914 FCGR ACTIVATION%REACTOME%R-HSA-2029481.3 FCGR activation 4067 2209 917 7525 2534 6850 3055 2214 2212 2268 ORGANIC ANION TRANSPORT BY SLC22 TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%561048 Organic anion transport by SLC22 transporters 9356 10864 55867 116085 9376 LDL REMODELING%REACTOME%R-HSA-8964041.4 LDL remodeling 4018 319 5034 338 4547 1071 SENSORY PROCESSING OF SOUND BY INNER HAIR CELLS OF THE COCHLEA%REACTOME%R-HSA-9662360.2 Sensory processing of sound by inner hair cells of the cochlea 7430 10083 64787 222662 83715 783 389207 2059 5756 51475 5962 6853 140469 2036 6855 4627 8573 6804 490 3778 3779 832 9381 6711 80331 6709 5864 6616 4478 829 4641 129446 440699 25861 27445 161497 6844 124590 51168 11344 64072 9132 8927 4647 53904 494513 9750 9478 259236 65217 23136 339768 117532 117531 25794 246213 643226 830 286262 10518 776 5357 53405 9254 DEFECTS IN TOLL-LIKE RECEPTOR CASCADES%REACTOME DATABASE ID RELEASE 95%5602358 Defects in Toll-like Receptor Cascades 2244 51135 2266 7100 114609 3551 5970 4615 81793 2243 6279 7187 148022 10333 6271 8517 4792 81622 7098 3146 23643 6280 4790 7097 7096 7099 948 695 4791 51284 929 1147 MITOCHONDRIAL RNA DEGRADATION%REACTOME%R-HSA-9836573.1 Mitochondrial RNA degradation 25996 10128 81892 9238 60493 22868 87178 6832 2926 COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 95%6811436 COPI-independent Golgi-to-ER retrograde traffic 84516 1781 1780 1778 22930 10540 8655 1783 56894 5050 829 5049 5321 140735 10121 5870 2590 11258 5048 51560 8398 25782 832 51143 55860 51164 22931 830 2589 10671 636 1639 23299 93661 TRNA AMINOACYLATION%REACTOME%R-HSA-379724.3 tRNA Aminoacylation 23395 833 10056 51520 1615 3376 124454 7965 9521 9255 80222 6301 5859 4141 55157 79587 2058 4677 5917 3735 10352 23438 3035 25973 6897 2617 5464 2193 79731 92935 57038 51067 57176 57505 7453 16 10667 55699 27068 54938 8565 NEUROFASCIN INTERACTIONS%REACTOME%R-HSA-447043.2 Neurofascin interactions 6386 286 23114 4897 1272 1641 8506 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF OTHER TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866906.3 TFAP2 (AP-2) family regulates transcription of other transcription factors 7022 10370 5308 7020 AURKA ACTIVATION BY TPX2%REACTOME%R-HSA-8854518.4 AURKA Activation by TPX2 10383 10382 1781 1778 7846 5566 9793 7277 5518 9738 6790 9662 7840 11064 22994 22995 7283 10733 80321 203068 55722 1454 1453 3320 55125 9814 22974 11190 115106 79441 95681 1069 54801 983 10142 9702 10540 8655 5347 5108 11116 4751 55142 3161 22897 54930 5116 79959 80184 93323 5577 23354 22981 8481 80254 121441 55755 23332 7532 10806 10121 7531 55559 8636 22919 11258 5048 84131 4957 55835 54820 DEFECTIVE PMM2 CAUSES CDG-1A%REACTOME%R-HSA-4043911.4 Defective PMM2 causes CDG-1a 5373 REGULATION OF PD-L1(CD274) EXPRESSION%REACTOME%R-HSA-9909648.1 Regulation of PD-L1(CD274) expression 2146 91445 84661 6048 11091 91319 8452 5133 23476 10956 5928 5929 3727 2354 6772 5931 8405 10331 9070 80380 8726 8945 3659 1019 5970 7415 58508 8970 8331 10987 25937 4297 8337 8463 128312 8334 8335 2033 8370 55766 8968 8341 8342 8347 8348 94239 8345 3013 8340 8338 255626 6774 3021 653604 3018 3017 85236 3014 84061 8349 474382 54145 1650 595 83439 100128731 1499 6185 7991 51176 6932 7004 6934 6184 7003 5562 7005 5563 58505 201595 5564 5565 467 746 10413 1603 3703 4609 4343 51422 192669 23112 27327 26523 4613 5571 192670 27161 57690 9861 23512 6233 2034 53632 9978 3091 2932 7316 10213 4791 29126 5706 3716 5707 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 4751 5685 5686 5717 5718 5719 4780 1460 27248 11047 1387 79139 5713 1459 5714 51009 5690 5691 1457 5692 6400 5693 5694 7311 7979 5695 7532 7314 4790 8454 11160 5687 5688 2353 5689 142678 6500 3725 10613 LOSS-OF-FUNCTION MUTATIONS IN DLD CAUSE MSUD3 DLDD%REACTOME DATABASE ID RELEASE 95%9907570 Loss-of-function mutations in DLD cause MSUD3 DLDD 594 1629 1738 593 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 95%429947 Deadenylation of mRNA 9125 57472 1981 9924 255967 25904 85456 9775 23019 4850 1975 29883 55571 4848 1974 4849 1973 1977 9337 246175 26986 79670 23318 10605 5073 DEFECTIVE MUTYH SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 95%9608290 Defective MUTYH substrate processing METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 95%196849 Metabolism of water-soluble vitamins and cofactors 51293 6948 55788 6515 5167 55312 8566 113278 51248 80308 55065 79581 54 143 133686 56965 83666 84875 79668 54956 54625 25902 6573 160428 2350 441024 4548 200895 1727 81034 4522 4524 10840 10797 10588 160728 9962 9963 1528 10243 93100 83594 23057 5646 23475 8884 128240 2194 27010 6472 92014 64802 4907 5644 31 55191 79178 55328 4338 55739 4363 80704 1504 27231 952 440387 55034 349565 65220 8034 10135 8875 5168 10560 5169 80025 60386 284439 54981 254552 80347 53354 6470 79877 79646 60496 79717 55229 60490 9390 326625 27304 4036 316 55163 6947 4552 9446 4837 113235 2694 27249 25974 4594 6513 166785 119391 5826 26119 683 64087 81693 5096 686 5091 56922 3141 32 8876 1719 5095 8029 EARLY SARS-COV-2 INFECTION EVENTS%REACTOME%R-HSA-9772572.4 Early SARS-CoV-2 Infection Events 91782 5045 23479 92421 85437 375790 59272 3339 7415 6383 1514 221914 5925 27243 9672 128866 10082 6385 1655 29082 2262 6382 2239 25978 2719 2817 30849 81631 26762 7405 79643 8829 51652 7428 5289 7113 8678 LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME%R-HSA-446343.3 Localization of the PINCH-ILK-PARVIN complex to focal adhesions 5829 3611 55742 3688 NADPH REGENERATION%REACTOME DATABASE ID RELEASE 95%389542 NADPH regeneration 3417 48 FORMATION OF THE EDITOSOME%REACTOME DATABASE ID RELEASE 95%75094 Formation of the Editosome 200315 339 9582 10930 27350 29974 164668 403314 TP53 REGULATES METABOLIC GENES%REACTOME%R-HSA-5628897.6 TP53 Regulates Metabolic Genes 143686 8626 5052 1327 7001 5562 9377 5563 7248 5564 1329 5565 389541 50484 28956 1340 57521 55004 8649 4697 7157 4343 51422 10670 192669 1337 6009 23112 27327 26523 5571 341947 192670 64121 83667 27161 1339 64223 57690 153129 1351 9167 1350 53632 2475 9997 1349 7249 1347 58528 10542 1346 10325 1345 2810 2539 7534 2821 7296 27165 4512 2744 4513 54541 4514 207 7295 7529 5728 125965 10971 7532 7531 7533 84701 2877 208 10000 57103 54205 613227 CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%R-HSA-69273.10 Cyclin A B1 B2 associated events during G2 M transition 993 7465 1017 891 994 9088 2305 995 983 55320 51343 51400 28227 5347 55355 902 51451 5520 90381 79596 5519 151648 79866 5515 5516 5518 9133 890 7514 8900 4331 1022 EXTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME%R-HSA-140834.4 Extrinsic Pathway of Fibrin Clot Formation 2158 2155 7035 2159 2152 SWI SNF CHROMATIN REMODELERS%REACTOME%R-HSA-9932451.1 SWI SNF chromatin remodelers 23506 65980 29998 55274 60 26039 8289 55193 6760 53335 64919 6595 6597 6599 57492 6598 29117 9274 9275 5977 6601 51412 8193 6603 6602 6605 196528 6604 605 8110 86 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME DATABASE ID RELEASE 95%174430 Telomere C-strand synthesis initiation 23649 5422 79991 5557 5558 26277 25913 7013 65057 7014 54386 100134934 80169 CA ACTIVATED K+ CHANNELS%REACTOME%R-HSA-1296052.3 Ca activated K+ channels 3783 27094 10242 3781 27345 3778 3780 3779 3782 TAT-MEDIATED ELONGATION OF THE HIV-1 TRANSCRIPT%REACTOME DATABASE ID RELEASE 95%167246 Tat-mediated elongation of the HIV-1 transcript 2071 2966 6829 2965 2963 2962 2068 5434 5435 5436 5437 5438 5439 2968 8178 2967 22916 404672 25920 5430 4686 5431 51224 5432 6924 5433 7936 902 6827 6749 9150 6917 1025 51497 7469 11198 904 6921 6923 5440 5441 4331 1022 PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME%R-HSA-6794362.6 Protein-protein interactions at synapses 57669 58512 10611 91683 94030 341359 57555 85358 9454 9455 347731 347730 2036 9456 22829 22941 57622 50944 8495 57497 8496 79414 26037 78999 26045 5789 10313 57596 2037 2035 9229 26280 9369 5802 54413 8573 6804 55327 84189 9378 9379 320 114798 64130 143425 2892 8825 321 84631 2893 139065 2890 127833 1742 1741 1740 80059 2906 1739 2905 2904 28988 2903 2319 2902 8541 8497 8499 8500 6857 2911 11141 2915 5792 10211 26050 23136 22871 9066 22865 57502 81858 6812 9546 4916 22839 QUIZARTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702620 quizartinib-resistant FLT3 mutants 2322 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME DATABASE ID RELEASE 95%3323169 Defects in biotin (Btn) metabolism 31 64087 5096 686 5091 56922 3141 5095 SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME DATABASE ID RELEASE 95%4755510 SUMOylation of immune response proteins 7341 6612 10210 9641 51588 5610 8517 4792 7329 10401 4791 5970 UPTAKE AND ACTIONS OF BACTERIAL TOXINS%REACTOME%R-HSA-5339562.5 Uptake and actions of bacterial toxins 7296 5045 3320 1938 3326 6616 6857 5609 6416 10015 6804 6844 808 2984 112755 79849 127833 5604 1839 5605 928 22987 9899 6843 9900 DISEASES ASSOCIATED WITH N-GLYCOSYLATION OF PROTEINS%REACTOME DATABASE ID RELEASE 95%3781860 Diseases associated with N-glycosylation of proteins 7841 91869 79087 2683 4247 199857 56052 85365 440138 79868 79053 9526 29929 10195 4758 2720 11253 1798 79796 5476 GLYCOSAMINOGLYCAN-PROTEIN LINKAGE REGION BIOSYNTHESIS%REACTOME%R-HSA-1971475.6 Glycosaminoglycan-protein linkage region biosynthesis 26229 375790 3339 6383 221914 9672 10082 6385 2262 6382 2239 2719 2817 1462 27087 9917 80146 92370 63827 64131 1634 64132 11285 126792 633 135152 1464 1463 10675 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME DATABASE ID RELEASE 95%3065679 SUMO is proteolytically processed 7341 6612 6613 205564 59343 29843 TERMINAL PATHWAY OF COMPLEMENT%REACTOME%R-HSA-166665.5 Terminal pathway of complement 730 731 732 733 735 727 1191 729 GLYCOSAMINOGLYCAN METABOLISM%REACTOME DATABASE ID RELEASE 95%1630316 Glycosaminoglycan metabolism 1836 9334 9331 1462 2990 23553 3373 10331 112937 8372 113189 3074 3073 63827 1634 3425 79411 411 2720 3423 633 1464 89944 1463 10675 2683 284129 10861 10090 11041 29940 51363 92126 10057 51000 11046 11261 8692 3038 347734 3037 55576 57214 3036 6677 10894 9469 80146 11285 126792 9061 9060 9348 4060 64579 26229 64711 375790 2131 3340 90161 222537 2799 2331 10855 26035 9957 60495 176 3339 9955 6448 9956 8509 4669 6383 221914 9653 266722 9672 10082 6385 9953 9951 2262 6382 9394 2239 2137 2135 2719 2817 2588 27087 960 9917 92370 64131 64132 6483 6482 6484 135152 6487 11081 8534 23563 93010 4969 10678 8703 8704 8702 4166 9435 4958 79369 5549 6548 3161 1514 22856 337876 55501 50515 55790 54480 166012 79586 55454 56548 26503 10402 CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER%REACTOME DATABASE ID RELEASE 95%2219530 Constitutive Signaling by Aberrant PI3K in Cancer 2252 2251 4233 8074 2249 2248 2247 2246 2323 2322 152831 5879 8823 5295 5296 940 2264 5290 5291 2255 9846 3667 930 118788 3084 941 942 146850 5880 6714 5294 23533 2100 50852 1950 2064 6801 1956 2099 374 5156 2534 5781 3932 3082 27006 8503 2549 5159 9542 8660 5293 10718 4915 145957 4909 3815 627 10818 7039 685 5155 255324 2069 8817 26281 7409 1839 391 9965 2254 4916 4908 NUCLEOTIDE CATABOLISM%REACTOME DATABASE ID RELEASE 95%8956319 Nucleotide catabolism 57089 56953 954 7378 955 4860 151531 956 1890 1807 1806 51733 84618 64902 30833 25939 7498 4907 953 957 9583 131870 22978 11164 10591 55270 93034 377841 3704 56985 9615 DEFECTIVE SLC29A3 CAUSES HISTIOCYTOSIS-LYMPHADENOPATHY PLUS SYNDROME (HLAS)%REACTOME%R-HSA-5619063.4 Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) 55315 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME DATABASE ID RELEASE 95%917729 Endosomal Sorting Complex Required For Transport (ESCRT) 91782 92421 55048 89853 9146 10254 51534 9525 137492 27183 51271 51160 8027 155382 93343 7251 79720 51510 27243 128866 29082 25978 7311 7314 84313 6233 51028 11267 7316 79643 51652 SIGNALING BY EGFR IN CANCER%REACTOME%R-HSA-1643713.4 Signaling by EGFR in Cancer 11140 3320 1950 5335 2549 867 7311 1956 7314 6233 7039 685 255324 2069 7316 5295 374 1839 6464 6654 4893 5290 3265 SIGNALING BY FGFR2 FUSIONS%REACTOME%R-HSA-8853333.2 Signaling by FGFR2 fusions 2263 TLR3 DEFICIENCY - HSE%REACTOME%R-HSA-5602410.3 TLR3 deficiency - HSE 7098 INTRACELLULAR OXYGEN TRANSPORT%REACTOME DATABASE ID RELEASE 95%8981607 Intracellular oxygen transport 58157 4151 114757 TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 95%112307 Transmission across Electrical Synapses 10052 57369 84694 24145 56666 TRANSCRIPTIONAL REGULATION BY VENTX%REACTOME DATABASE ID RELEASE 95%8853884 Transcriptional Regulation by VENTX 8881 64682 25906 11065 8697 7324 10393 29945 1029 595 27338 119504 29882 5970 246184 1499 996 51176 51343 51434 51433 6934 79813 27287 1051 10919 7157 4343 192669 23112 27327 26523 192670 4790 57690 3569 1436 51529 7321 SHC-MEDIATED CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 95%5654699 SHC-mediated cascade:FGFR2 2252 27006 2255 2251 8074 2249 2248 2247 2246 8823 8817 26281 6654 4893 2254 3265 COPII-MEDIATED VESICLE TRANSPORT%REACTOME%R-HSA-204005.6 COPII-mediated vesicle transport 23256 63908 51399 4905 10342 10959 22872 2890 6811 9871 9632 6396 1294 10972 10427 5537 966 79090 22870 9117 11196 254263 81562 1453 27095 149111 9919 2801 89866 7109 6399 23243 2348 10175 126003 25956 55014 10802 10652 51693 1522 3998 122553 1075 10484 83696 90411 10282 58485 26984 55291 79748 128637 374 10960 5265 81876 5861 2153 10113 9554 9570 64689 7039 8774 8775 51128 8615 2157 APAP ADME%REACTOME DATABASE ID RELEASE 95%9753281 APAP ADME 2678 8714 124975 2687 6822 2950 2686 55748 95 10057 2944 1571 2952 6818 7366 10257 9 10 54578 6783 6817 54575 54600 54658 1244 9429 445329 27233 4363 OTHER INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 95%449836 Other interleukin signaling 6382 3716 6809 3603 146433 1440 6844 1441 7297 6810 6616 1435 3588 9235 1436 6813 163702 920 5803 282618 836 200081 5657 6804 INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 95%264876 Insulin processing 5126 56605 64924 169026 4644 5873 25924 149371 55763 6804 3630 6844 55770 3798 3799 23265 60412 54536 5034 57393 3800 1363 10640 5122 11336 DRUG-MEDIATED INHIBITION OF CDK4 CDK6 ACTIVITY%REACTOME DATABASE ID RELEASE 95%9754119 Drug-mediated inhibition of CDK4 CDK6 activity 595 1021 1019 894 896 INTERACTION WITH CUMULUS CELLS AND THE ZONA PELLUCIDA%REACTOME%R-HSA-2534343.4 Interaction With Cumulus Cells And The Zona Pellucida 7784 22917 6677 2683 5016 8747 8748 57829 7783 2515 11085 BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME%R-HSA-9018678.5 Biosynthesis of specialized proresolving mediators (SPMs) 1544 1571 4048 1543 1565 1559 5743 240 241 3248 246 1576 2053 22949 239 2948 4056 1558 L1CAM INTERACTIONS%REACTOME%R-HSA-373760.4 L1CAM interactions 163 7430 6708 100133941 2596 6710 6712 5962 1759 57698 1175 1173 1785 1808 8986 6324 6323 11313 27330 6331 6330 6332 6335 6334 214 6326 26052 8506 6328 6327 6329 57731 6711 6336 11280 23114 55800 8650 1463 287 3915 288 51332 2048 6386 284217 1956 3912 6709 8515 27255 1641 5594 5595 3785 3786 7410 3690 3680 4684 3685 3674 3897 24137 3678 8829 5604 5605 6456 1272 5879 3673 3688 1742 1741 1739 3312 285643 286 4897 6900 8828 10048 4478 1460 1459 1457 6197 6196 9252 6195 3672 1213 1211 5058 10752 160 161 ION HOMEOSTASIS%REACTOME DATABASE ID RELEASE 95%5578775 Ion homeostasis 478 53822 53826 53828 5566 480 6546 1193 481 4842 6547 2281 482 3710 483 486 7137 80228 487 488 489 84876 7220 6717 6263 490 6262 1760 491 808 492 493 6261 6786 6543 815 3708 3709 816 5350 817 818 444 5348 5349 10345 6588 10768 10060 476 3767 477 APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 95%5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 4968 79661 11284 7515 5423 3980 252969 DEFECTIVE F9 ACTIVATION%REACTOME DATABASE ID RELEASE 95%9673221 Defective F9 activation 2158 2811 2160 2812 2815 2814 FORMATION OF NEURONAL PROGENITOR AND NEURONAL BAF (NPBAF AND NBAF)%REACTOME%R-HSA-9934037.1 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 55274 60 26039 8289 6760 53335 64919 6595 6597 6599 57492 6598 9274 9275 5977 6601 51412 8193 6603 6602 6605 6604 605 8110 86 RET SIGNALING%REACTOME%R-HSA-8853659.7 RET signaling 55816 5335 5623 85358 55715 2887 5909 5566 64096 5567 4902 5568 9260 9048 9046 1796 5295 5296 6464 5781 5290 5291 8503 5979 9846 2549 8660 5293 53358 2886 10818 5578 5598 2668 220164 2676 2675 6654 2674 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 95%418555 G alpha (s) signalling events 113 2854 799 114 79924 2850 554 115 3375 594857 2870 10266 10268 2695 107 10267 108 55970 109 10203 196883 2863 5566 5567 5568 5739 2869 5138 54331 53831 59345 408 5443 5153 409 2642 2641 1081 116 117 2782 135 10681 1395 5136 2778 10846 50940 2692 2691 4158 9340 2740 7433 6344 7432 6343 7434 2696 5573 5140 5575 5576 5577 3972 1392 9287 3363 3362 3640 3360 153 155 3678 170589 1816 5741 83551 1812 134864 319100 122042 1394 134860 9038 3274 5744 5745 5746 2492 136 3688 2781 346562 151306 5729 5732 5734 4157 7252 4161 4160 4159 117579 113091 2771 6714 2770 6019 7253 5032 2773 122876 2852 551 3973 154 59350 2793 387129 2792 2791 2790 156 2788 2787 2786 10888 2785 2784 2783 51764 2488 8622 5141 5143 5144 5139 57105 5151 5150 157 11245 11250 94235 285601 2838 2843 133 2848 111 796 112 27115 797 SIGNALING BY CSF3 (G-CSF)%REACTOME DATABASE ID RELEASE 95%9674555 Signaling by CSF3 (G-CSF) 3716 1440 8651 6776 1441 7297 6772 6464 6850 5781 3055 9846 9616 8065 7311 9021 7314 3845 7323 7322 6233 4067 2885 7316 6921 6774 6923 6777 7321 3717 PHASE 3 - RAPID REPOLARISATION%REACTOME%R-HSA-5576890.4 Phase 3 - rapid repolarisation 3741 3753 10008 3757 9992 23704 3784 23630 10142 PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME%R-HSA-5654219.4 Phospholipase C-mediated cascade: FGFR1 2255 27006 2251 5335 8074 2249 26281 2248 2247 2246 2254 CO-INHIBITION BY CTLA4%REACTOME DATABASE ID RELEASE 95%389513 Co-inhibition by CTLA4 5515 207 5516 5518 5525 941 5526 4067 942 208 10000 5527 5528 5529 7525 1493 2534 5781 5519 3932 DEFECTIVE SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME DATABASE ID RELEASE 95%5619044 Defective SLC6A19 causes Hartnup disorder (HND) 340024 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME DATABASE ID RELEASE 95%139853 Elevation of cytosolic Ca2+ levels 84876 5027 7222 9127 5023 7225 5024 5025 5026 22953 6786 3710 3708 57113 3709 80228 TGFBR3 REGULATES FGF2 SIGNALING%REACTOME DATABASE ID RELEASE 95%9839397 TGFBR3 regulates FGF2 signaling 7049 10755 2247 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME%R-HSA-9646304.4 Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects 1029 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%R-HSA-2465910.4 MASTL Facilitates Mitotic Progression 5515 84930 5516 5518 2029 891 55844 5519 983 10776 SARS-COV-2-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 95%9705683 SARS-CoV-2-host interactions 3454 7097 7096 9871 9632 7335 9641 3665 10427 26276 6230 6210 6231 6234 6235 6191 22863 2197 7334 6193 6192 6194 51065 140032 6205 6227 6204 10971 6207 6229 6206 6228 6209 6208 6188 6187 6223 6201 6189 6222 6203 6224 6202 6218 6217 3921 51311 3551 3326 3107 3106 3134 3133 6233 8767 57506 3654 9868 8678 7534 8021 3135 3716 207 7297 10802 7529 10484 114548 3838 89122 10392 23586 7532 7531 857 7533 7706 84282 6885 3105 6772 567 7187 64398 7189 3661 340061 29110 5648 2697 81631 348995 80143 7405 9883 6396 129401 9688 10454 57122 23225 4927 64127 23165 55746 55706 23636 9631 3320 7175 9972 11097 23279 8086 23511 53371 8480 79023 79902 10762 64135 5903 6232 5781 8517 30849 208 5289 1147 3656 257397 23118 79760 91662 27072 84818 6607 3442 23339 5170 3441 9908 10146 3440 79833 11218 23765 6441 11311 3452 4153 3451 25929 3449 7555 3448 10207 3447 57617 64601 23367 3446 3445 54960 3444 55823 3443 8487 7284 65082 3456 2810 92359 9636 50628 26007 3605 112744 6632 1387 5777 7082 6628 6634 51128 6633 6636 10000 6635 6637 51284 6773 ESSENTIAL FRUCTOSURIA%REACTOME DATABASE ID RELEASE 95%5657562 Essential fructosuria 3795 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME%R-HSA-77289.7 Mitochondrial Fatty Acid Beta-Oxidation 3030 51102 84320 11332 23597 1892 284486 1666 414149 80221 58488 641371 33 134526 34 35 117145 4594 166785 1622 84693 4706 10965 55856 84129 80724 142827 27349 5096 10449 1632 5095 6296 37 26027 3033 3032 MEIOTIC SYNAPSIS%REACTOME%R-HSA-1221632.3 Meiotic synapsis 474382 54145 4001 7329 8468 10734 6847 10388 9985 23345 23224 644186 23353 25777 27127 93426 256126 8970 56158 8331 672 8337 8243 128312 50511 9126 8334 8335 10735 8370 55766 5885 10274 8341 8342 8347 8290 8348 94239 8345 26277 3013 25913 8340 7013 65057 7014 8338 545 255626 54386 3018 3017 85236 3014 8349 3306 DEFECTIVE RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-HSA-9693928.5 Defective RIPK1-mediated regulated necrosis 8772 11035 8737 8717 197259 7186 841 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME DATABASE ID RELEASE 95%1168372 Downstream signaling events of B Cell Receptor (BCR) 4793 3551 6885 10125 10892 84433 25780 808 9861 2280 4794 6233 5966 7316 10213 8945 5706 5707 5708 5709 5478 4773 5700 4775 5701 5970 5702 5704 5705 5682 23291 5683 5684 5685 5686 5717 5718 5719 4893 11047 5713 4772 5579 5714 5690 5534 5691 5692 8517 4792 5693 5694 7311 7979 5695 7314 4790 8454 5530 5687 5532 5688 5689 8915 6500 1147 3265 GENE SILENCING BY RNA%REACTOME%R-HSA-211000.5 Gene Silencing by RNA 474382 54145 201164 23405 8575 7257 54487 6895 7247 192669 23112 27327 10526 221400 26523 122402 55124 192670 27161 84944 5901 54456 57690 11022 91646 4603 113802 8468 9271 56165 136991 144233 57510 29102 5440 5441 3320 54514 5434 5435 5436 5437 60528 5438 5439 5430 5431 5432 5433 8970 8331 8337 128312 8334 8335 8370 55766 283 8968 8341 8342 8347 8348 94239 8345 3013 8340 8338 255626 143689 3021 653604 3018 3017 85236 3014 8349 TYPE II NA+ PI COTRANSPORTERS%REACTOME DATABASE ID RELEASE 95%427589 Type II Na+ Pi cotransporters 142680 6569 10568 NUCLEOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 95%774815 Nucleosome assembly 378708 474382 54145 79172 5928 91687 79682 80152 2491 5931 64946 387103 8467 55839 54069 8607 11339 51773 4869 55320 55355 8970 1060 8331 8337 128312 55166 8334 201254 8335 1058 79019 8370 55766 8341 8342 8347 8348 94239 8345 3013 23421 8340 57082 8338 255626 64105 401541 3018 3017 85236 3014 8349 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN APOPTOSIS%REACTOME%R-HSA-9824594.3 Regulation of MITF-M-dependent genes involved in apoptosis 4343 192669 23112 597 27327 3065 26523 25942 3094 192670 27161 57690 5454 4308 79444 596 23405 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME DATABASE ID RELEASE 95%5654228 Phospholipase C-mediated cascade; FGFR4 2251 8074 5335 2249 2247 2246 152831 8823 8817 26281 9965 2264 2254 TBC RABGAPS%REACTOME%R-HSA-8854214.2 TBC RABGAPs 338382 125058 54662 55357 57533 11337 11021 7879 79735 5867 26000 10133 5868 4218 83452 7248 128637 23163 4943 23637 26088 64786 23062 84958 382 57465 5870 51762 51560 83874 374403 81631 11345 729873 8408 7249 9230 8766 51256 5869 9363 27342 5878 9135 CELLULAR HEXOSE TRANSPORT%REACTOME%R-HSA-189200.7 Cellular hexose transport 144195 200010 6513 6514 91749 66035 26291 11182 29988 81031 85414 6524 6515 6523 55974 56606 6527 125206 6517 154091 155184 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%R-HSA-438064.5 Post NMDA receptor activation events 114 107 5566 5567 5568 5879 5562 5563 5564 5565 5924 5170 51422 27330 8536 5571 808 88 2891 2890 3084 5923 1742 53632 1741 1740 2906 1739 2905 815 2904 4900 6714 2903 816 4747 2902 817 818 5573 5575 5576 4893 5577 5613 3838 10645 84254 6197 814 6196 5594 5595 6195 28964 3265 ASSEMBLY OF THE HIV VIRION%REACTOME DATABASE ID RELEASE 95%175474 Assembly Of The HIV Virion 5045 5478 7311 7314 55048 89853 6233 137492 51271 51160 155382 93343 7251 79720 7316 9397 PLASMA LIPOPROTEIN REMODELING%REACTOME%R-HSA-8963899.3 Plasma lipoprotein remodeling 5045 5046 5125 4018 213 335 336 337 27329 4547 26291 55908 3990 8720 64788 9619 345 84699 1071 344 348 9388 338 51360 338328 319 51129 91289 5034 4023 116519 PLATELET SENSITIZATION BY LDL%REACTOME%R-HSA-432142.4 Platelet sensitization by LDL 5777 7804 5321 5515 5516 5518 338 5175 2268 5525 5526 5527 5528 5529 1432 5781 5519 BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 95%352238 Breakdown of the nuclear lamina 4001 839 DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME DATABASE ID RELEASE 95%5683678 Defective ABCA3 causes SMDP3 21 DISEASES OF PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 95%9759785 Diseases of propionyl-CoA catabolism 4594 166785 OVARIAN TUMOR DOMAIN PROTEASES%REACTOME DATABASE ID RELEASE 95%5689896 Ovarian tumor domain proteases 7706 8737 80124 79931 55593 64135 84282 983 5728 2099 55611 54764 10318 7415 7187 7189 79155 7157 55432 23252 7128 89122 8517 10392 56957 7311 23586 7314 6233 8767 57506 161725 7316 324 79589 387 64127 78990 7321 ZYMOSTENOL BIOSYNTHESIS VIA LATHOSTEROL (KANDUTSCH-RUSSELL PATHWAY)%REACTOME DATABASE ID RELEASE 95%6807062 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) 1595 6721 1718 50814 6307 7108 51478 6720 THE NLRP3 INFLAMMASOME%REACTOME%R-HSA-844456.10 The NLRP3 inflammasome 5027 29108 10628 4790 351 4210 5970 3326 10910 7295 9051 114548 3162 834 4791 24145 DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME DATABASE ID RELEASE 95%5654716 Downstream signaling of activated FGFR4 2251 8074 5335 2549 2249 2247 10818 2246 10817 152831 8823 8817 5295 26281 9965 2264 5781 6654 4893 5290 2254 3265 METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME DATABASE ID RELEASE 95%5263617 Metabolism of ingested MeSeO2H into MeSeH 7296 SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%8847453 Synthesis of PIPs in the nucleus 8396 5305 79837 90809 IRON UPTAKE AND TRANSPORT%REACTOME DATABASE ID RELEASE 95%917937 Iron uptake and transport 127124 7036 79901 23545 51382 9843 533 534 535 537 10312 50617 9296 2495 2512 7018 6233 4738 57192 7316 3162 55832 10539 3658 79689 3934 55240 3163 245972 245973 113235 155066 9114 51606 7311 26234 7314 8454 9550 3077 523 525 526 527 1356 7037 528 529 6500 8992 9429 4891 51310 48 30061 94033 90423 PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME%R-HSA-8849471.4 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 1398 9844 1793 5879 5829 9564 5753 2909 387 5921 4893 3265 63916 RUNX3 REGULATES WNT SIGNALING%REACTOME DATABASE ID RELEASE 95%8951430 RUNX3 regulates WNT signaling 6932 6934 595 864 83439 1499 51176 4609 CD28 CO-STIMULATION%REACTOME DATABASE ID RELEASE 95%389356 CD28 co-stimulation 253260 9402 207 5063 57761 5879 1326 5295 5296 940 2534 9020 5519 3932 5290 5291 5170 8503 117145 998 55615 5515 5293 5516 64223 5518 2475 5525 941 5526 4067 942 208 5058 10000 5527 5528 146850 5529 5294 23533 7525 7409 1493 79109 5062 SIGNALING BY EXTRACELLULAR DOMAIN MUTANTS OF KIT%REACTOME%R-HSA-9680187.2 Signaling by extracellular domain mutants of KIT 3815 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME DATABASE ID RELEASE 95%881907 Gastrin-CREB signalling pathway via PKC and MAPK 1956 6197 6196 5594 5595 6195 4314 5578 5598 887 1839 6654 4893 2520 3265 DEFECTIVE ABCD4 CAUSES MAHCJ%REACTOME%R-HSA-5683329.4 Defective ABCD4 causes MAHCJ 5826 55788 SIGNALING BY RNF43 MUTANTS%REACTOME DATABASE ID RELEASE 95%5340588 Signaling by RNF43 mutants 8325 7855 8322 4040 54894 8323 4041 89780 DEFECTIVE SLC9A9 CAUSES AUTISM 16 (AUTS16)%REACTOME DATABASE ID RELEASE 95%5619052 Defective SLC9A9 causes autism 16 (AUTS16) 285195 EARLY PHASE OF HIV LIFE CYCLE%REACTOME%R-HSA-162594.4 Early Phase of HIV Life Cycle 5478 2547 7520 3981 7518 8815 3978 7852 2237 920 1234 3836 3159 11168 MATURATION OF PROTEIN E%REACTOME DATABASE ID RELEASE 95%9694493 Maturation of protein E 7316 7311 7314 6233 MET ACTIVATES RAS SIGNALING%REACTOME DATABASE ID RELEASE 95%8851805 MET activates RAS signaling 4233 57610 10048 6654 4893 3082 200958 3265 CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR-MEDIATED ACTIVATION OF RAS SIGNALING%REACTOME%R-HSA-442742.5 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 5924 4893 5170 27330 6197 808 6196 5594 88 5595 6195 5923 1742 1741 1740 2906 1739 815 2904 816 4747 2902 817 818 3265 HEME BIOSYNTHESIS%REACTOME%R-HSA-189451.5 Heme biosynthesis 213 211 1352 1371 2235 7389 7390 3145 212 5498 9429 1355 210 ATTENUATION PHASE%REACTOME%R-HSA-3371568.2 Attenuation phase 3305 2033 3320 10728 3326 3304 3297 3281 3312 3337 2288 1387 3306 SIGNALING BY FLT3 FUSION PROTEINS%REACTOME DATABASE ID RELEASE 95%9703465 Signaling by FLT3 fusion proteins 9846 2120 5292 6776 2804 9321 399687 1026 7750 50507 6711 5295 6654 4893 5290 6777 3265 GAP JUNCTION TRAFFICKING%REACTOME DATABASE ID RELEASE 95%190828 Gap junction trafficking 10052 57165 375519 57369 2702 2701 2700 127534 2709 2707 2706 1759 2705 2703 219770 125111 1601 10804 1173 81025 84694 1785 8218 1212 4646 2697 1213 1211 GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME%R-HSA-389661.10 Glyoxylate metabolism and glycine degradation 58510 8528 8659 1743 2806 1738 4967 5827 54363 189 92259 2653 27232 64902 112817 2731 9380 275 1610 FORMATION OF THE ANTERIOR NEURAL PLATE%REACTOME DATABASE ID RELEASE 95%9823739 Formation of the anterior neural plate 5453 25925 5015 6656 7546 2637 5460 79923 6657 9839 5080 MDK AND PTN IN ALK SIGNALING%REACTOME DATABASE ID RELEASE 95%9851151 MDK and PTN in ALK signaling 5764 4192 5803 238 DEGRADATION OF AXIN%REACTOME%R-HSA-4641257.3 Degradation of AXIN 5706 5707 5708 5709 5700 5701 5702 5704 64750 5705 5682 5683 5684 5685 5686 5717 5718 5719 80351 11047 5713 5714 5690 5691 5692 5693 5694 7311 7979 5695 7314 9861 81847 6233 5687 5688 5689 8312 7316 8658 10213 8313 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME DATABASE ID RELEASE 95%2393930 Phosphate bond hydrolysis by NUDT proteins 131870 11164 55270 56985 NETRIN-1 SIGNALING%REACTOME%R-HSA-373752.4 Netrin-1 signaling 7430 4756 4690 5335 148738 9353 6091 137970 5879 285704 90249 116986 5306 22885 4651 84448 56963 57453 8976 5781 1630 3983 9423 6477 1826 998 7220 7204 7222 7224 8633 7223 6478 7225 219699 1793 6586 6585 5747 57113 6714 59277 5588 FORMATION OF THE CANONICAL BAF (CBAF) COMPLEX%REACTOME DATABASE ID RELEASE 95%9933937 Formation of the canonical BAF (cBAF) complex 6597 6599 57492 6598 60 9274 9275 26039 5977 8289 8193 6602 6605 6760 605 8110 6595 86 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME DATABASE ID RELEASE 95%1799339 SRP-dependent cotranslational protein targeting to membrane 23478 60559 28972 90701 6152 6155 6154 6157 9349 6156 6159 6158 23521 51121 11224 6164 200916 6166 6122 6165 6124 6168 6123 6167 6169 6125 116832 25873 6160 6161 140801 29927 4736 6130 6133 9045 6230 6232 6132 6210 6176 6231 6135 6234 6134 6235 6137 6191 6136 2197 6193 6171 6192 6170 6194 6173 6128 51065 6129 140032 6142 6205 6227 6141 6144 6204 6143 6207 6229 6146 6147 6206 6228 6181 6139 58477 6745 6138 6209 6208 6188 6187 6223 6201 6189 6222 6203 6224 6202 6218 6217 3921 6734 1650 6185 6184 55176 6233 6175 23480 6727 6731 6730 6729 6726 6728 23471 6746 6748 6747 10952 7311 9789 SLC-MEDIATED TRANSPORT OF INORGANIC ANIONS%REACTOME%R-HSA-9958790.2 SLC-mediated transport of inorganic anions 160728 6557 9498 6559 284129 26266 10861 6569 57282 1836 83697 6508 6522 10568 6561 9497 115111 57835 6521 6574 6560 9990 10723 57468 6568 6558 8671 142680 6528 6575 115019 5172 23382 1811 65010 TRAFFICKING OF AMPA RECEPTORS%REACTOME%R-HSA-399719.3 Trafficking of AMPA receptors 80852 2036 27092 7102 23426 4905 9495 4646 5582 10369 5579 10368 59283 2892 2891 2893 2890 1742 1739 815 5578 816 9463 817 818 160 4193 CLEARANCE OF SERATONIN%REACTOME%R-HSA-380615.6 Clearance of seratonin 4128 217 6532 SARS-COV-2 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9694682.4 SARS-CoV-2 Genome Replication and Transcription 85437 5925 7428 1655 ABACAVIR ADME%REACTOME%R-HSA-2161522.5 Abacavir ADME 22978 5243 6580 5105 124 6581 9429 161823 6582 TRUNCATIONS OF AMER1 DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 95%5467348 Truncations of AMER1 destabilize the destruction complex 5515 5516 5518 5525 5526 8312 2932 5527 324 5528 1452 5529 139285 5519 DEFECTIVE SLC12A1 CAUSES BARTTER SYNDROME 1 (BS1)%REACTOME DATABASE ID RELEASE 95%5619104 Defective SLC12A1 causes Bartter syndrome 1 (BS1) 6557 DIFFERENTIATION OF NAIVE CD+ T CELLS TO T HELPER 1 CELLS (TH1 CELLS)%REACTOME%R-HSA-9942503.2 Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) 4772 861 6348 30009 864 8459 3458 6775 3595 7124 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 95%15869 Nucleotide metabolism 7298 3615 57089 3614 7083 51727 4832 4833 56953 954 7378 955 151531 956 1890 1807 1806 51733 84618 64902 30833 6240 1841 50484 4830 471 2745 102157402 6241 131870 22978 11164 10591 55270 93034 8226 7084 3704 7371 56985 9615 83549 54963 978 7372 790 7296 2987 1723 7295 161823 4860 270 271 3251 56474 272 51292 132 100 353 122622 5471 203 1633 5198 204 2766 205 1716 10606 158 159 8833 2618 1503 25939 4831 79077 122481 7498 158067 4907 953 957 221264 9583 26289 1635 377841 25961 CLOSTRIDIUM NEUROTOXICITY%REACTOME DATABASE ID RELEASE 95%168799 Clostridium neurotoxicity 6844 112755 22987 6616 9899 6857 127833 6843 9900 6804 BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME%R-HSA-9025094.3 Biosynthesis of DPAn-3 SPMs 246 5743 239 240 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME DATABASE ID RELEASE 95%209560 NF-kB is activated and signals survival 4792 4803 7311 7314 3551 4790 4804 8878 5970 6233 3654 7316 7189 HEMOSTASIS%REACTOME%R-HSA-109582.5 Hemostasis 4352 6566 3053 682 5023 4072 5024 5025 5026 22953 5739 2983 2268 2982 6546 462 5138 4842 4312 6547 4843 3710 4846 10335 5152 5153 5593 4099 80228 487 488 489 84876 5027 27094 7804 6717 5321 9127 490 491 492 493 27345 338 3778 3779 1398 5175 6786 5136 6543 5051 2977 2778 10846 3708 3709 10242 50940 3660 3659 708 5868 23428 14 9056 9057 6520 8140 23657 6693 56301 10451 7441 7410 440533 914 5670 11136 7056 5671 5672 5673 6401 90952 830 5675 4097 51378 7409 5669 10544 5680 10630 8832 51266 29802 5676 80739 27154 5678 6404 1525 2734 3543 83953 120425 5197 4267 285 2995 2994 962 2993 10461 10672 4973 2888 2207 972 5879 83692 51744 1048 6383 9672 6385 6382 3684 6915 2817 960 961 7035 2165 965 4067 3635 3689 146850 5294 23533 10603 4680 5478 6647 4282 5055 1072 140885 302 5547 1088 2793 829 2792 1084 2791 6402 5581 2790 5582 2627 5579 2788 2787 2786 5328 2785 5329 2784 64145 2783 55423 51764 3043 3672 161882 3675 3655 7525 9630 5588 94235 3705 55970 7465 54331 2767 5269 59345 408 409 2769 7277 7157 2782 2776 10681 832 2625 5880 25 57126 1062 5196 5781 4893 8503 998 9732 5594 5595 9585 23046 24137 387 26153 391 55605 388 6654 3265 22920 634 55614 146909 5099 81930 84643 55582 3796 23303 5216 80005 5583 9162 8527 26090 8525 8526 5295 57406 3688 5296 5770 221955 160851 6464 9371 221458 1609 5519 747 5290 1608 5291 1607 5170 1606 547 139189 5515 11004 5516 55083 808 5518 88 2886 1795 1794 1793 113220 3797 5525 5526 3832 5527 3833 5528 3834 5529 3835 6714 90990 7422 2768 7424 7423 285643 2277 3717 2244 2266 23095 10749 7414 54518 5028 7450 2243 3937 7094 1445 124602 27040 56992 64147 2534 6850 3932 7044 2159 3082 5265 2621 2147 22915 10490 2158 2155 5267 29789 5624 2153 5627 3481 350 94121 351 5890 197 3479 51368 64805 8407 10257 2151 12 5155 5552 2149 22927 2162 1 51097 23052 2157 9749 3920 928 135228 9002 54495 5889 5336 10916 6403 813 51706 2 7076 7078 7873 7114 3671 66005 5894 213 23186 3273 335 5906 3827 5908 1521 5566 6414 6810 5567 139322 11069 5568 308 10938 10411 55604 3700 6814 2152 10235 221037 6813 10362 10125 8165 25970 10487 51317 3309 11216 3046 7123 5340 3045 5341 81928 5345 23764 29106 23414 83706 3048 3047 3959 50808 54676 710 30846 1893 30845 64780 259215 5473 140628 5657 10184 78991 51571 967 9948 6694 7222 5004 334 5919 55664 7225 5874 7018 3699 1191 10019 374354 7273 10447 54863 5005 2316 81 5768 2161 2160 5270 2812 57113 3818 5104 2815 2814 2335 11093 7010 284 8515 51206 23759 9046 5573 5575 5576 5577 83700 150 151 152 3065 25942 1017 87 5327 58494 5580 5578 7534 3683 207 1020 55619 3676 1432 29127 4778 857 1675 7040 11127 8654 481 482 483 54210 139818 1950 5335 3512 9564 50848 5590 85440 81704 9493 23348 2624 8968 4602 10112 57572 3690 3685 3674 3897 3678 3021 653604 9463 7043 8795 7042 8793 8797 6678 3687 23028 11343 6281 5271 7102 23539 5054 9123 3673 346562 3442 3441 3440 11311 3452 3066 3451 23468 3798 3799 3449 3448 3447 948 3446 9927 3445 55669 3444 3443 2811 3456 2771 64837 2770 89953 147700 2773 3831 7057 226 91768 7975 5777 2623 2626 5747 5660 7066 CELLULAR RESPONSES TO STRESS%REACTOME%R-HSA-2262752.13 Cellular responses to stress 5611 1327 5928 1329 1340 1337 5931 2931 1339 1351 338 1350 1349 1347 118 1346 100137049 1345 10072 3552 5584 5970 4899 26043 125965 64839 571 55666 3068 55062 10954 58477 6745 10113 10897 4000 3329 23643 9797 4189 3569 116138 1386 9570 6818 23657 7099 7709 56005 10106 55033 1663 1200 2134 6734 10294 64061 55860 51164 115209 11015 3337 55738 830 6604 5598 4097 2288 5226 55466 10671 1639 4306 4363 613227 51266 93661 3306 3305 84516 3301 8714 10728 10370 8878 5599 79813 4208 3310 4697 2137 2135 8453 7323 7322 2034 126374 84962 9978 2289 3091 112399 112398 8994 367 6921 6923 64344 54583 7428 4194 6175 6648 4193 3313 7353 6647 6888 114548 829 1460 1459 1457 79594 6197 7531 6196 6195 3043 23410 2056 23411 9429 81502 7157 9451 348995 50507 832 9883 6396 129401 9688 57122 9817 23225 3336 4927 3159 23165 25828 55746 55706 9588 10963 23636 9631 7175 9972 11097 23279 2950 8086 23511 53371 8480 79023 79902 10762 5903 2099 6232 8655 2876 3163 2908 7415 493869 140809 79400 245972 30001 245973 10061 257202 2938 155066 1728 2940 10935 9114 27244 51606 644 645 84181 5594 6649 5595 9572 318 2880 9550 2878 523 10587 525 2882 526 9973 527 51143 208 528 529 8992 90423 127124 1781 51382 1780 6347 1778 2887 57761 6095 533 534 9377 10312 1783 10919 6464 9296 3576 140735 83667 9167 8131 201163 55846 5526 23334 3297 440275 3281 815 144577 23677 84219 10641 7422 81929 816 55364 652968 4199 96459 2539 817 729438 818 79726 10985 51529 7321 154743 8881 9681 64682 57600 25906 54468 11065 11133 8697 7324 10393 29945 27338 119504 29882 246184 7094 996 51434 51433 472 672 10111 7979 4361 8454 4683 51360 10524 545 6117 890 8900 6119 6500 79728 5034 6118 213 335 8720 3309 84699 768 475 3397 22872 1670 343 9530 8945 7086 538 811 6230 6210 6231 6234 6235 11331 6191 2197 30968 10730 6193 6192 6194 51065 140032 6205 6227 6204 6207 6229 6206 6228 1915 6209 6208 6188 6187 6223 6201 6189 6222 6203 6224 6202 6218 6217 3921 4851 5753 25942 1029 1017 3326 1026 8894 79094 1054 5563 1051 23645 3417 440 10891 1965 389541 27102 467 468 28956 22809 57521 1968 55004 1649 4609 8649 4343 192669 10670 6009 23112 27327 10525 26523 10808 27230 192670 3040 64121 64223 57690 5580 153129 9861 6233 11340 84335 8570 2475 9261 23404 58528 54512 10542 3312 10325 7316 7514 3162 10213 5393 23016 8021 5608 5073 5706 5707 1536 5708 51010 5709 4512 1535 4513 167227 4514 51013 207 5700 5701 4688 5702 4689 118460 5704 10540 5705 5682 5683 5684 5685 27287 5686 9820 22894 5717 5718 5719 1432 10424 56915 11047 1030 5713 5714 5690 10628 5691 5692 5693 5694 7311 847 5695 10121 7314 4790 84701 11258 3304 5687 5688 5600 5689 653361 54205 3484 2146 10013 25994 4001 3024 8452 29855 10498 25842 8091 7290 23523 57634 3009 3008 405 3007 3006 3005 406 7184 341947 6737 81631 5465 6152 6155 6154 6157 9349 6156 6159 8726 6158 23521 51121 11224 6164 200916 6166 6122 37 6165 6124 6168 3320 5469 6123 6167 1950 6169 6125 116832 25873 5241 7027 1021 6160 1019 6161 140801 27000 4736 259217 116835 1871 898 6130 7266 51182 6133 1870 573 51343 9045 6502 6767 6132 6176 51501 57805 6135 9134 6134 9531 1027 6137 9532 22824 6136 6782 7029 91582 55620 6171 1869 9529 6170 5925 8970 6173 10049 3308 6128 8331 6129 6142 8337 128312 6141 6144 8334 6143 8335 6146 2033 6147 6181 8370 6139 55766 6138 8968 23135 8341 8342 8347 8348 8290 94239 8345 3013 26277 25913 8340 7013 65057 7014 8338 255626 54386 6256 6774 3021 653604 3018 3017 85236 3014 8550 8349 474382 54145 2168 5052 6907 7001 8648 79718 84447 5609 9695 6416 5601 9612 7867 5602 8204 5606 8841 9611 8535 23054 6045 648 6015 23466 1912 1911 23512 80012 57332 84733 2932 3456 139285 51726 7296 4209 2730 2673 4862 2729 7295 80205 23373 85441 10743 10499 96764 374 9575 596 64784 4780 10130 5154 200186 598 1387 6667 2114 7975 2113 113235 10488 1032 9812 1031 3490 90993 148327 23043 50488 7466 9448 26353 153222 27429 81501 4800 1388 4801 2353 4217 4802 2077 2081 9709 55662 2877 64764 10000 22926 2309 9361 1410 3725 30827 KW2449-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702569.2 KW2449-resistant FLT3 mutants 2322 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME DATABASE ID RELEASE 95%77346 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 3030 51102 1892 34 3033 3032 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 95%187687 Signalling to ERKs 673 4803 5898 5906 7529 1399 7867 6464 1432 4893 5899 25759 6014 6016 2889 6300 5594 5603 5595 53358 10818 4914 5900 57498 1398 9261 5600 5604 5605 6654 3265 DENGUE VIRUS INFECTION%REACTOME%R-HSA-9839923.1 Dengue Virus Infection 163 4904 5611 10914 10594 10236 721 11325 55749 335 27238 10921 11338 29894 3309 1175 1173 6430 3069 6432 6431 1660 5593 8175 23524 55763 1655 8729 10450 6427 6426 7318 9076 6429 7317 57703 6428 10533 712 1191 8189 51729 5356 716 27339 9641 1665 84991 722 3181 725 3188 929 3187 3185 3184 2521 7448 9716 51503 10421 3192 285755 3191 11100 64225 3190 689 440400 1993 9295 811 4666 3837 91937 22937 550 83443 7301 4061 7307 51234 22924 10949 22863 55236 55666 10015 9685 2194 23643 7099 3178 3921 10294 4836 84061 3839 2923 402569 3840 3841 23601 1650 3326 100128731 1499 6185 7991 10461 23352 5824 6184 58505 201595 6383 221914 821 9672 10082 6385 746 57521 1603 3703 945 2262 7341 6382 55615 2239 558 10525 1977 2719 7329 2817 64223 6233 57506 2475 4067 3312 7316 7514 5440 8678 5441 7353 4318 2963 6993 2962 4360 1981 5434 5435 5436 5437 5438 5439 25777 5430 5431 5432 4751 5433 1982 80273 8672 317649 1994 3838 9039 4792 317772 7311 7314 85235 26986 54464 3304 10965 79876 11314 79109 9789 23478 7706 60559 5045 28972 90701 7431 10250 27316 3183 7251 79869 115004 6238 340061 221613 81631 29959 92815 8969 3836 440689 253260 3320 8737 64135 1616 1654 9532 7415 8970 8331 4691 8337 6141 128312 8334 8335 8370 1974 1973 8968 23168 8341 8342 8347 79577 8348 30849 8345 51639 3013 80349 53938 123169 8340 8896 9646 81608 8338 10898 255626 23283 54623 51645 653604 3018 3017 5289 85236 24148 6886 55696 8349 55339 10945 1479 4793 1478 1477 375790 23020 85313 10992 9879 9410 8683 3339 10084 11051 57551 9775 10313 5295 5725 10523 9785 10291 10978 4153 199746 53981 9416 8449 9382 26762 10181 8106 51692 815 57794 816 10189 4670 8974 30835 817 22938 54431 818 283208 51726 5033 51340 10527 51585 22826 22827 10283 8813 8241 5093 5094 22916 8818 51593 23350 4686 10286 10285 988 9343 6632 57461 84844 2621 56259 2147 51362 6627 5627 6629 7082 6628 220988 10262 10946 23450 54344 23451 54883 6634 56949 6633 6636 5546 6635 6638 54463 6637 5034 10907 160 161 6773 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME DATABASE ID RELEASE 95%1592389 Activation of Matrix Metalloproteinases 7076 5045 1511 4317 1504 4318 1991 50859 7077 440387 5340 4312 10893 4313 5645 1513 1515 4320 4314 80781 5644 4322 4319 4316 4323 1215 3818 4324 4325 4326 7177 64386 3817 INTEGRIN SIGNALING%REACTOME DATABASE ID RELEASE 95%354192 Integrin signaling 2244 2266 54518 5906 5908 207 7450 2243 11069 7094 1445 10411 10235 10125 9564 5770 6464 6850 5170 1398 3690 3674 5747 6714 6654 2335 METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME DATABASE ID RELEASE 95%2408508 Metabolism of ingested SeMet, Sec, MeSec into H2Se 1491 27232 191 4143 875 3176 4837 51540 SLC-MEDIATED BILE ACID TRANSPORT%REACTOME DATABASE ID RELEASE 95%9958517 SLC-mediated bile acid transport 204962 80736 60482 23446 345274 57153 126969 NEGATIVE REGULATION OF NMDA RECEPTOR-MEDIATED NEURONAL TRANSMISSION%REACTOME%R-HSA-9617324.2 Negative regulation of NMDA receptor-mediated neuronal transmission 22843 8536 814 808 88 9647 1742 1741 1740 2906 1739 2905 815 2904 2903 816 4747 2902 817 818 ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME%R-HSA-379397.7 Enzymatic degradation of dopamine by COMT 4128 220074 1312 MPS IIID - SANFILIPPO SYNDROME D%REACTOME DATABASE ID RELEASE 95%2206305 MPS IIID - Sanfilippo syndrome D 2799 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME%R-HSA-373076.10 Class A 1 (Rhodopsin-like receptors) 2846 553 554 594857 64106 301 129521 128674 2867 3827 2865 2863 2862 60675 4922 5739 4923 10800 8620 680 27334 84634 3060 5367 23620 3062 3061 10316 6753 4828 4829 5473 84539 729230 27202 135 719 2847 163404 8698 57121 9170 9890 23566 64748 9294 4852 727 54886 728 79948 1903 1902 1901 53637 1235 1129 1128 1133 1132 1131 9287 3363 3362 150 3361 151 3360 152 59340 153 155 165140 3358 3357 3356 3355 1816 83551 1815 1814 1813 1812 134864 319100 134860 9038 3354 3352 3274 3351 3350 146 147 148 3269 11255 4935 136 5956 5729 11251 5731 5732 5733 5734 5737 6915 7252 2357 4986 4988 3579 3577 154 6750 718 2864 183 5443 2652 1081 2919 6010 4158 5196 3972 221391 611 5995 10692 23596 3640 51083 1240 56670 170589 4987 3792 27198 27199 6288 2587 4886 6351 4887 6352 4889 58191 122042 6354 6357 6356 2359 6348 1269 6347 1268 6349 2826 10850 6361 2492 4543 9034 6364 4544 6363 6366 6367 1230 6751 6360 5540 6752 2833 5539 643 10663 116512 6373 338442 6372 6755 6374 10022 6376 6754 6370 8811 1238 339403 2921 57007 151306 2920 8843 1237 5697 1236 256933 1233 7504 3576 1232 51289 56477 4142 8862 4283 6387 51052 4157 6346 10803 51554 9718 4161 10563 3627 4160 5368 4159 117579 5173 7852 1234 5020 4295 7200 6019 5021 1524 7201 7253 56413 5031 5032 1909 8484 1908 186 187 94233 2798 2834 2797 2832 2796 2831 1907 122876 5028 1880 1906 283869 84432 2841 5029 57486 6375 2853 1241 2852 551 2693 2859 1910 50865 84109 1889 10874 2861 29933 9283 3973 10887 9290 5724 59350 10886 1325 257313 2532 387129 2358 4985 8111 8477 2922 2147 6870 6863 2925 6865 6846 6866 10161 6869 185 351 5030 623 53829 624 140 2488 64805 134 56923 9934 2151 2150 57105 2149 2829 2828 5179 885 886 887 2837 347148 9002 338557 5660 3814 10911 2840 552 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%977068 Termination of O-glycan biosynthesis 6480 256435 27090 143662 118430 4582 4583 4584 4585 4586 200958 56667 727897 10071 94025 140453 4588 4589 283463 10610 6483 394263 6482 6484 6487 DEFECTIVE F9 VARIANT DOES NOT ACTIVATE FX%REACTOME%R-HSA-9673202.2 Defective F9 variant does not activate FX 2158 2157 2159 POLYMERASE SWITCHING%REACTOME%R-HSA-69091.4 Polymerase switching 23649 5422 5557 5558 5111 10714 5424 5425 5981 57804 5982 5984 5983 5985 ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%75108 Activation of BID and translocation to mitochondria 3002 637 4836 841 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%R-HSA-113418.5 Formation of the Early Elongation Complex 2071 2966 6829 2965 2963 2962 2068 5434 5435 5436 5437 5438 5439 2968 2967 22916 404672 25920 5430 4686 5431 5432 5433 7936 902 6827 9150 51497 7469 5440 5441 4331 1022 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 95%166208 mTORC1-mediated signalling 10670 6009 1978 1977 1981 64121 64223 153129 2280 84335 7529 2475 6198 58528 10542 10325 389541 6194 29904 28956 1975 57521 55004 8649 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 95%140342 Apoptosis induced DNA fragmentation 3148 3146 3024 3837 3009 3008 1677 3007 1676 3006 3005 3836 836 COMPETING ENDOGENOUS RNAS (CERNAS) REGULATE PTEN TRANSLATION%REACTOME%R-HSA-8948700.2 Competing endogenous RNAs (ceRNAs) regulate PTEN translation 4343 192669 23112 27327 26523 192670 27161 57690 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME DATABASE ID RELEASE 95%5685942 HDR through Homologous Recombination (HRR) 348654 146956 197342 84464 23514 80198 79008 6233 7316 10714 5424 5425 5981 57804 7486 5982 56655 5883 5884 5983 116028 3364 472 5429 10635 672 675 5426 84126 5427 1111 83990 51426 144715 63979 83695 51750 5810 7516 10111 5932 54107 7517 7311 7979 5111 4361 7314 7156 5890 9156 5892 55732 4683 11073 580 10524 641 1763 545 6117 5984 5985 6119 79728 5888 6118 80010 5889 RECEPTOR MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 95%8934903 Receptor Mediated Mitophagy 1459 8408 9474 1457 84557 139341 1460 81631 9140 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%R-HSA-2453902.7 The canonical retinoid cycle in rods (twilight vision) 285440 24 4647 10170 6121 8608 6010 64220 5949 51109 7276 9227 5950 157506 5959 6017 145226 5947 50700 8630 3292 121214 CELLULAR RESPONSE TO HEAT STRESS%REACTOME DATABASE ID RELEASE 95%3371556 Cellular response to heat stress 3305 10728 10013 3326 3309 3310 57521 10808 64223 84335 9261 2475 348995 9883 6396 129401 3297 3281 3312 9688 815 2932 57122 23225 816 4927 23165 817 9530 818 8021 55746 55706 23636 9631 3320 7175 3313 9972 11097 23279 8086 23511 53371 8480 27000 79023 259217 79902 116835 10762 7266 5903 51182 573 6767 51501 57805 9531 9532 22824 7415 6782 91582 9529 472 10049 3308 1387 2033 1915 26353 5594 7531 5595 3304 23411 545 6117 1410 6119 3337 2288 6118 3306 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%R-HSA-2514853.4 Condensation of Prometaphase Chromosomes 1459 10592 9133 1457 23397 891 983 1460 10051 9918 64151 SIGNALING BY BRAF AND RAF1 FUSIONS%REACTOME DATABASE ID RELEASE 95%6802952 Signaling by BRAF and RAF1 fusions 55750 9061 5894 5906 5908 55109 27044 57670 8805 56829 408 9715 409 23164 8546 57085 11044 54845 9444 808 10533 10827 8087 815 6714 816 817 818 2335 3717 673 8826 22906 2244 2266 7414 8844 10256 54518 22866 4140 7450 5037 2243 7094 7529 1445 369 10142 283455 4893 4000 5594 10018 5595 3690 3674 1185 5604 5605 80853 3265 VLDLR INTERNALISATION AND DEGRADATION%REACTOME DATABASE ID RELEASE 95%8866427 VLDLR internalisation and degradation 163 29116 7311 7314 6233 1213 1211 1175 7436 1173 7376 7316 255738 10062 160 161 DRUG ADME%REACTOME DATABASE ID RELEASE 95%9748784 Drug ADME 3615 3614 6566 213 682 28234 1576 4830 9 10 22978 55270 3704 9376 1558 1557 2987 1645 6822 2950 1559 10249 123876 161823 4860 341392 219970 92292 3251 54988 389396 132 64078 100 2030 10057 2938 1571 5243 866 3177 1565 4831 9153 7363 133688 6581 55315 7365 7498 6818 7364 7367 7366 10451 7410 54490 79799 54578 54577 5444 54576 574537 54575 54658 7409 54657 54579 4363 167127 10941 10720 8714 5446 54659 5879 3291 3290 5105 348158 6579 10864 6582 590 2678 124975 2687 6580 2686 55748 95 2939 124 1066 8833 2944 7172 2952 8824 10257 6783 10599 6817 54600 1244 9429 445329 27233 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME%R-HSA-964739.2 N-glycan trimming and elongation in the cis-Golgi 4245 10905 4121 79694 57134 RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME DATABASE ID RELEASE 95%5668599 RHO GTPases Activate NADPH Oxidases 5579 1536 124056 10811 1535 6280 5594 5300 5580 5595 30849 4688 4689 6279 5600 5879 5880 50508 5578 5590 653361 5289 1432 27035 NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 95%5654732 Negative regulation of FGFR3 signaling 673 8074 867 7311 5515 2249 7314 5516 5594 5518 5595 2247 6233 10818 2246 8823 7316 8817 26281 10253 8569 5781 2254 KEAP1-NFE2L2 PATHWAY%REACTOME%R-HSA-9755511.5 KEAP1-NFE2L2 pathway 8452 9451 6737 81631 10072 9817 8945 1950 7086 5584 5970 26043 6502 64839 571 7415 55666 140809 10061 2033 2938 1728 2940 27244 84181 6649 23657 4851 208 4097 5226 4363 8714 6347 5052 1029 8878 1026 5563 3417 468 4609 83667 5580 9861 6233 9978 2932 7316 139285 3162 10213 4199 2539 5706 7296 5707 5708 5709 7353 2730 6888 207 5700 5701 2729 7295 5702 5704 5705 5682 5683 5684 5685 5686 5717 374 5718 596 5719 4780 5154 672 598 1460 11047 1387 6667 7975 5713 1459 5714 5690 5691 1457 5692 5693 5694 7311 7979 5695 79594 7314 4790 8454 5687 5688 5689 10000 79728 6500 9429 THE CRY:PER:KINASE COMPLEX REPRESSES TRANSACTIVATION BY THE BMAL:CLOCK (ARNTL:CLOCK) COMPLEX%REACTOME%R-HSA-9931521.1 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex 1454 8864 1453 8863 406 9575 4862 1408 4297 1407 5187 1387 DEFECTIVE GSS CAUSES GSS DEFICIENCY%REACTOME DATABASE ID RELEASE 95%5579006 Defective GSS causes GSS deficiency 2937 RHOH GTPASE CYCLE%REACTOME%R-HSA-9013407.3 RHOH GTPase cycle 397 55968 7879 9475 10298 1445 55717 57144 6093 396 81839 398 7415 3728 253959 3932 55004 1627 7535 9497 55075 157769 1629 857 2631 2040 10376 56924 7037 5058 114885 9528 6510 4548 9341 399 5062 NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION%REACTOME DATABASE ID RELEASE 95%164940 Nef mediated downregulation of MHC class I complex cell surface expression 10053 8907 8905 130340 1174 162 55690 164 3105 567 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME%R-HSA-425407.6 SLC-mediated transmembrane transport 51296 6564 1497 121260 6566 9152 682 6557 6559 9843 26291 126969 28234 81031 6546 6569 1836 6584 6547 10568 6578 283652 51248 6717 57084 6536 6543 6556 6540 140679 6529 54716 64078 23428 92745 23443 23169 6511 2030 6533 23568 206358 389812 84889 10999 6509 120103 51000 11046 55089 117247 3933 347734 340024 10991 286256 7355 6506 6505 8884 376497 6507 28965 9056 222962 9057 153201 3177 9197 6520 8501 9153 23446 6541 9154 84912 123096 81539 55315 8140 23657 55117 56301 11254 6512 6539 11136 6519 124935 54407 80736 6528 6575 6579 6510 10864 6582 6580 353189 6560 10723 57468 6558 83733 5002 402 6515 6532 204962 57030 79751 291 292 293 8402 154091 155184 9376 65010 144195 1468 55356 55244 160728 159963 284129 10861 57153 66035 28231 284111 6508 6522 55974 55867 6527 6517 125206 11309 6561 6563 115111 57835 6574 6576 6534 6568 6567 91749 6581 6583 6538 345274 11182 115286 85414 85413 64849 7781 115019 7780 23382 64116 6248 29986 57181 146802 25800 25769 80024 29985 84102 7779 254428 1317 23516 9356 64924 861 169026 27173 200010 55532 7922 283375 57419 9498 26266 8170 29988 53919 57282 83697 9058 23539 9123 9194 133418 9497 347 808 9187 115584 114134 6526 551 84679 6550 6553 389015 6548 6549 10479 285195 55343 23315 10559 6521 9990 6513 60482 26503 6514 116085 8671 6531 6530 142680 123041 1356 6524 6523 10599 246213 5172 55630 56606 4891 30061 1811 DIMERIZATION OF PROCASPASE-8%REACTOME%R-HSA-69416.5 Dimerization of procaspase-8 8772 8797 8737 355 356 8717 8795 7186 8743 841 MEIOTIC RECOMBINATION%REACTOME DATABASE ID RELEASE 95%912446 Meiotic recombination 474382 54145 1017 4292 27030 4438 4439 84057 56979 23626 1019 11144 8970 472 8331 29893 672 8337 675 128312 8334 8335 63979 8370 55766 10111 8968 5932 8341 4361 8342 7156 8347 8290 8348 94239 8345 55732 4683 3013 8340 641 8338 6117 255626 6119 3021 653604 3018 5888 6118 3017 85236 3014 5889 8349 RUNX2 REGULATES GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME%R-HSA-8941333.2 RUNX2 regulates genes involved in differentiation of myeloid cells 861 865 3958 FCERI MEDIATED MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 95%2871796 FCERI mediated MAPK activation 4214 5335 9402 3937 5599 5879 5609 6416 5601 5602 6850 4893 5594 5595 2353 10451 7410 4067 5058 7409 3725 6654 5336 3265 5062 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 95%2474795 Diseases associated with visual transduction 24 611 64220 7276 9227 5950 5959 222236 6017 145226 5956 5947 2652 SIGNALING BY NOTCH4%REACTOME%R-HSA-9013694.3 Signaling by NOTCH4 83464 51107 59 23493 3516 9861 23462 8850 6233 3280 9978 7316 2324 10213 7534 22938 55534 5706 5707 5708 5709 4088 207 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 9794 2648 1387 11047 5713 5714 2033 5690 5691 5692 5693 182 5694 7311 7979 5695 7314 84441 8454 5687 5688 5689 10046 4851 4853 4855 10460 388585 6500 102 54567 5663 23385 55851 5664 TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME%R-HSA-8953750.3 Transcriptional Regulation by E2F6 23269 84108 2146 7027 8317 1876 5928 79813 4149 7029 10138 10919 1869 672 1111 6045 83746 80314 648 6015 5931 5932 23468 8409 1911 6241 23512 11335 23429 80012 7703 8726 317 5888 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%R-HSA-1362409.6 Mitochondrial iron-sulfur cluster biogenesis 51312 57128 122961 150274 81689 2395 112812 2232 51218 81894 2230 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 95%611105 Respiratory electron transport 55967 55969 25994 5018 1327 29796 440957 84987 57128 100303755 55744 1329 55863 790955 1340 4722 54539 91942 728568 1337 90871 341947 440567 1339 3052 29078 90624 1351 100131801 4706 137682 1350 192286 4705 9997 1349 79751 4707 1347 4708 4709 1346 1345 84300 4700 4701 4702 4704 6341 8402 79064 4716 493753 4717 4718 4719 51079 4710 4711 4712 4713 4698 54902 4715 125965 2395 613227 51295 150274 9377 4697 28976 4728 4729 27089 4720 4723 3954 4724 4725 4726 9167 25915 55572 29090 4731 152100 93058 100996939 116228 4190 28958 4191 55101 1355 51300 8604 1353 374291 3313 90639 4512 1537 4513 4514 6389 10063 55471 4519 80775 2806 2110 119559 6391 6390 6392 2108 55245 10975 51204 2109 4540 285521 4541 6834 4535 84233 4536 4537 4538 7385 7384 617 7386 7388 80219 7381 83733 84701 25880 80224 51103 2805 389203 284184 4694 10165 4695 4696 79133 57226 4714 51241 126328 54205 10131 FORMATION OF PARAXIAL MESODERM%REACTOME%R-HSA-9793380.5 Formation of paraxial mesoderm 1499 51176 2043 9241 3516 9861 8850 10213 22938 55534 5706 5707 5708 5709 5700 6911 5701 5702 5704 89780 5705 5682 5683 5684 5685 5686 5717 5718 5719 9794 2648 1387 11047 5713 5714 2033 5690 6862 28514 5691 5692 5693 5694 84667 7979 343930 5695 652 134701 3955 145873 84441 10683 5687 5688 5689 10046 4851 2260 METABOLISM OF PROTEINS%REACTOME%R-HSA-392499.12 Metabolism of proteins 54471 6150 55168 64949 91445 28973 6048 65080 51642 54998 5018 10573 11222 128308 51649 9553 10956 64960 92259 64963 6569 63875 64965 64968 55052 10568 55173 64969 51250 51373 149371 26284 51650 51253 60488 51258 55763 219927 29074 56945 8729 28998 64975 79590 64976 64979 55770 115416 64978 23107 28957 64928 23265 4706 7818 51263 60412 29088 378 51021 57129 54534 54536 51023 51264 8766 51069 84545 78988 122704 65993 64981 10240 64983 10640 3396 63931 11336 26589 54460 6182 6183 118487 51073 116540 740 124995 54148 116541 55037 29093 9801 51116 10884 54948 8451 51318 8533 9486 11041 9215 64708 29954 113829 729920 120071 7334 2218 146664 10329 7336 79147 10987 148789 10980 84892 10585 55624 1605 50813 84197 83475 64122 1984 23463 10920 79672 1642 56648 1725 7508 10401 38 622 3158 5019 55860 51164 830 10671 1639 4306 93661 84516 8878 56652 6742 8662 8663 8661 8666 8667 8664 8665 27335 3646 7341 51386 7022 7458 8668 7021 8669 10480 1964 7329 8453 7323 7322 2034 9978 3091 9617 57505 6921 6923 7453 16 64344 10667 55699 7428 27068 1917 54938 84340 8565 22980 23395 123263 23008 833 10056 1937 1936 4528 1933 55139 124454 9669 4539 6731 6730 80222 6729 85476 6726 6728 55157 79587 908 23471 113457 4677 6950 7203 219402 2793 54516 2792 6746 6748 7280 2791 6747 1460 1983 2790 10352 26272 23438 1459 90850 6905 3035 2788 25973 1457 6897 2787 2617 2786 9147 5464 83752 2785 2193 26234 79731 2784 92935 2783 57038 51764 10102 10693 51067 6468 92399 10376 57176 10694 6902 2629 26190 10575 80086 26270 6904 6903 9630 94235 51807 6000 22803 10381 8787 7411 10383 8786 10382 55294 112714 55135 26085 55970 402 9628 60 7846 84790 10471 5201 5202 6499 84617 5082 11328 54331 2767 10238 10517 59345 10342 26330 1155 84261 347733 2769 7277 7278 7157 22948 63971 2782 26985 26224 79861 81027 2804 2776 54461 10528 5203 10681 5204 8877 10564 348995 9883 6396 129401 9688 292 57122 293 23225 4927 23165 55746 55706 23636 9631 7175 9972 11097 23279 8086 23511 53371 8480 79023 79902 10762 5903 6232 8655 991 57591 51143 387 10196 1781 1780 1778 5905 1783 332 55143 3619 140735 9212 4791 2746 286 93010 10678 8703 8704 8702 79369 729238 3626 3625 3624 3623 2488 8454 83729 890 8900 6500 5566 59272 154881 7320 6477 22872 51088 9616 7317 7319 3093 9871 9632 150726 10427 118424 55336 7327 7326 3913 7328 3915 2335 54926 65264 93611 127247 3912 401036 79791 29927 811 51665 6230 51666 6210 6231 6234 6235 6191 2197 6193 142686 6192 6194 142685 55236 51065 51676 140032 5720 6205 6227 142689 6204 6207 6229 6206 6228 1915 80204 6209 6208 57542 6188 6187 6223 6201 6189 9554 6222 6203 6224 6202 23014 6218 6217 25793 3921 11275 64410 222235 54850 140456 140458 84164 140459 2923 10973 90135 146330 140460 140461 140462 54620 115290 7704 55958 8139 390594 55284 84961 1975 997 8924 122769 10670 1978 1977 55175 27252 55176 51130 26046 9903 9246 92369 126433 79090 26259 22870 11070 9117 11196 201456 144699 254263 81562 27095 899 84861 149111 92912 9919 89866 10477 7109 4253 5696 6399 26268 79694 2348 90293 7879 10175 84727 126003 92591 26263 25956 10802 55014 10652 51693 122553 26267 3998 10484 64377 53339 2525 83696 10489 285231 90411 89890 10282 26984 9820 79748 128637 26235 26118 10960 79176 26232 5893 5698 5699 84085 4008 51725 9039 26249 8065 84078 140739 9040 79754 84541 80176 136371 10324 2589 796 3375 7046 7048 7040 8459 8460 7184 7518 10331 6152 6155 26286 6154 6157 9349 6156 6159 6158 23521 51121 11224 6164 3895 200916 6166 6122 6165 6124 6168 6123 6167 6169 6125 116832 25873 6160 6161 140801 4736 53918 6130 6133 9045 6132 6176 6135 6134 6137 84364 6136 6059 6171 6170 6173 6128 6129 6142 6141 6144 6143 6146 6147 6181 6139 6138 92305 6596 23168 9781 56852 79577 51322 5591 80349 123169 51255 9646 257218 55829 9810 220441 54623 8915 6288 3371 3339 4148 1758 9189 8535 6304 6045 1107 83746 648 5610 8554 6015 3066 23468 9759 1912 1911 23512 23314 80012 57332 84733 6612 7703 6613 8312 324 139285 4248 2107 29104 327 23708 2935 10055 25950 10054 374 4780 4311 1066 4286 1387 81876 5861 5862 27429 64689 7039 8615 347688 9361 7153 260334 338 2350 2230 6440 8893 8891 8892 8890 5867 1967 9146 5868 6770 115209 4976 84061 3033 11282 7841 51201 55741 1650 11320 4247 100128731 4249 6185 7991 4124 4245 6184 25834 1048 23193 58505 201595 8875 2530 821 11253 5589 746 1603 3703 211 9986 6478 100287238 100287478 81847 51762 23682 9738 8767 9736 57506 728386 161725 4738 9230 23172 367 51651 9868 8658 93973 4194 9363 8314 7345 8678 7347 8313 4193 338382 57646 590 84101 4086 63891 7353 201475 4087 1122 4088 100287327 4089 11021 100287205 55593 9099 5872 9097 100287441 5728 23032 116442 64750 114785 248 23011 100288520 114548 10981 4092 154 10617 7375 392188 93624 11274 55252 377 5071 10868 57559 10869 23252 7128 89122 8473 384 4792 10392 317772 23586 79594 51552 79913 85235 4303 54617 43 84142 92552 9577 100287404 221937 64426 55031 23358 83844 123228 57695 79589 5886 84132 4798 5887 8239 10600 86 7706 56910 9100 9101 51588 25862 100287513 27005 23326 80124 55288 993 183 79931 401447 10254 84282 645836 6881 6885 8027 125476 55611 54764 51377 57599 5423 408 80351 409 1080 7187 7186 94005 7189 80055 79155 100287178 8733 29761 10026 54891 128869 51604 10474 29086 56957 54995 133686 7874 5832 221613 36 1643 9804 2235 8192 9929 171023 10845 27034 8850 645402 8975 8295 151194 2625 22944 79091 51720 92815 399818 254013 8724 221143 10454 8969 196483 8607 79609 9817 219333 440689 64127 1632 3054 100287144 84749 78990 126119 55777 23770 1540 8737 6314 329 91833 7528 3607 51616 84196 9960 8078 64135 377630 2099 29844 728419 63967 114803 330 10318 7415 9958 7417 7416 7419 2648 4287 79184 100287364 55432 283899 3972 83444 27430 8517 10445 1000 4644 5873 25924 8693 55568 442117 374907 11227 11226 374378 51809 64409 84752 140687 9245 114805 2650 168391 192134 63917 51146 146712 117248 51301 26290 50614 57452 79623 10164 5029 2922 338557 143471 389362 56984 51371 11338 80227 122706 5710 10197 5711 8624 5715 5716 84262 9491 23198 2641 1655 1294 6670 3090 668 2683 51514 3190 4061 150 152 217 10891 27089 4723 4967 4731 4191 4508 4509 3419 10632 3418 4512 4513 4514 4519 653509 6439 2109 4540 4541 4535 4536 4537 4538 7385 5222 1755 221395 29080 643834 9476 29995 643847 5875 4200 5876 509 4695 2271 3486 3484 632 8801 1743 522 5443 539 10476 1081 6790 5465 5468 4719 51079 4712 5241 7421 145173 57188 2591 200845 143662 79695 10417 118430 10418 170689 171019 54437 9510 9037 4582 5199 4583 7058 6672 4584 4585 4586 200958 157869 727897 29071 9507 140766 80070 9508 9509 10071 94025 339366 221981 79875 81794 140453 55901 4588 4589 81792 283463 9719 56999 56913 394263 11173 11096 2028 11095 57393 11174 3800 80731 1363 170690 1360 1359 54507 170692 1636 92949 5972 170691 5126 56605 89978 92715 197370 1938 493861 9656 286053 51611 23137 285381 79677 120526 56160 1802 54780 1801 9761 64772 80267 84447 10299 55768 9695 10206 56886 51564 267 51035 7844 55757 11236 4152 6294 10210 9994 115426 7690 10521 3798 3799 124872 10155 354 51209 114907 7155 7150 23275 9367 3817 7057 79812 129080 84750 170384 115827 64284 4978 7295 22854 503542 27076 22846 57799 5865 1045 376267 1043 7068 3952 205564 80328 84932 59343 51602 6975 146183 54872 8934 84276 161357 10130 1087 3485 3483 419 23556 54757 51246 420 150465 8404 349667 8542 1471 25941 3491 432 3490 433 3489 79739 158135 3488 9021 3487 284098 80740 7466 64856 284076 349633 10117 3816 23287 1114 53942 152330 258 7857 5277 11167 5279 2626 10232 249 5954 5283 130576 56955 251 4240 4241 5281 5179 9654 3270 5067 265 54839 401138 93183 51156 8581 91851 7007 5069 360226 11019 28996 147111 2813 51280 56975 27247 2822 60676 10618 164395 5611 80235 9487 3956 9488 4924 3053 146760 2999 7070 26140 721 11091 8614 50863 2519 51715 84628 375056 23093 10272 84871 174 646627 1327 1435 123624 54972 3698 387787 84141 2653 5929 9210 340351 11098 57403 257194 462 1368 54587 4312 401409 7425 58530 4313 10966 284348 1329 154064 390243 79805 7512 266727 55647 353091 25837 1361 137797 79841 55650 51299 23627 5931 25809 4045 91978 116372 4062 115273 23170 8434 374969 142684 7369 254173 171169 54965 51227 8000 54742 123904 60509 84720 966 83871 57111 10942 147719 83639 1604 83887 51601 84992 8073 1121 5864 4869 5970 4878 27166 3329 3569 10890 4221 81619 2215 51499 22921 4482 5110 253827 5870 51734 5869 22931 5878 6727 1075 29099 5329 5111 23412 683 8876 6696 326624 5371 401258 9545 11031 94115 290 10159 7276 55832 51816 1512 142 1522 2908 58485 2517 53916 53917 9314 1315 7181 6095 9377 4929 2516 59348 3622 2266 2243 2677 2159 2621 2147 2158 2155 8858 5624 5627 1629 1738 338328 51128 255738 5034 116519 213 335 336 337 8720 8835 9306 9641 8945 11093 9112 3028 84864 23210 2058 51504 5537 64326 1453 165918 23243 1069 7158 10540 55291 10121 11258 25879 7045 9027 793 23163 6622 10098 54959 5617 26088 325 9627 9445 6653 23621 340348 23062 3015 23555 1439 1438 444 57719 1487 8243 9126 10735 5885 10274 6996 64924 169026 6441 7284 51520 1615 3376 7270 7965 9521 9255 6301 57104 5859 4141 10499 5917 3735 90268 29089 1789 1788 1786 219 84002 285362 79642 25870 340075 410 412 414 415 416 9334 22901 10959 9331 153642 347527 135 619373 7941 1395 2688 7349 10537 55208 7332 10072 28952 23142 26094 54939 9655 23038 140825 23369 54951 23363 1154 54165 149951 1161 80344 55827 23113 84259 6709 56929 79016 51122 54876 50717 83987 26043 150684 8816 90864 170622 10116 79269 2934 51397 55884 55527 56995 28991 80067 55666 123879 8883 122416 58477 6745 10113 9570 6734 11015 55738 102 23385 55851 83464 51107 80028 23194 91433 100137047 79697 55854 79831 1819 51389 4733 55239 65094 6383 136 2719 7252 1215 6175 375 3313 5721 829 2627 7019 5096 11315 3670 5122 9789 5080 23478 60559 2864 28972 2695 90701 139760 1803 4722 56667 6811 832 10970 6711 3630 6472 26958 1509 8774 8775 23256 10945 63908 8074 51014 57511 3416 339122 23423 372 84342 91949 4121 4122 381 51272 57134 9527 21 22796 808 2590 29843 2890 9382 51560 347517 10972 5162 5163 25839 9276 5160 7321 11316 83548 11065 7324 10905 1737 10466 27338 22818 983 1314 54732 23291 7486 4218 54734 51226 83452 27314 22820 672 11014 9609 5265 22915 2153 3481 7979 351 197 3479 580 641 6117 2157 79728 135228 813 6708 7076 6710 6712 3827 4057 5340 29106 4069 6694 334 5874 7018 5768 57731 287 288 51332 80341 1511 2801 91689 6406 6687 10939 23203 221154 10730 4052 652 2200 3065 25942 1029 5828 1026 1499 51399 6934 197257 8894 29928 51142 1965 498 1968 4609 6804 1891 9861 6233 26519 3312 7316 10213 23480 8021 5706 50 5707 5708 5709 5195 1981 5700 5701 5192 5702 5193 5194 5704 5705 5682 26520 5683 5684 5685 5686 5717 5718 5719 11047 5713 1431 5714 5690 5691 6844 5692 5693 5694 7311 10952 5695 7314 26986 10965 5687 5688 5689 10440 506 79644 718 5045 90865 8452 3183 56254 2873 3105 10574 51138 567 9318 10576 1462 5987 411 2720 79823 898 6502 1616 9134 8970 8331 8337 128312 8334 8335 2033 1974 8370 1973 8968 8341 8342 8347 8348 8345 3013 8340 8338 255626 6256 6774 3021 653604 3018 3017 85236 3014 8349 5914 474382 54145 8648 7376 9612 4905 8204 8841 346562 221656 348 140838 29906 207063 6675 56052 81849 440138 79053 84920 51046 5973 51005 10610 6483 22845 6482 6484 55808 6487 6489 64841 5476 10020 3098 79087 256281 6480 144245 256435 10825 55577 2673 8813 27090 30815 9945 85365 197258 8818 7264 29929 4351 10195 4597 338596 8790 29926 29925 55343 29880 1798 79796 10559 79139 84620 2762 91869 51009 8869 5238 116150 6400 5372 5373 55907 8128 57171 26503 282969 199857 54187 80896 54344 79868 9526 79947 1356 7903 4758 10402 129807 4759 91574 64432 65003 64951 65005 65008 28977 90480 51081 PROLACTIN RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 95%1170546 Prolactin receptor signaling 2690 6776 2689 8454 5618 1442 9978 2688 6500 5781 8945 6777 5617 3717 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-HSA-2142770.2 Synthesis of 15-eicosatetraenoic acid derivatives 246 2876 247 2877 5743 2879 VPR-MEDIATED INDUCTION OF APOPTOSIS BY MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION%REACTOME DATABASE ID RELEASE 95%180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization 291 292 293 SIGNALING DOWNSTREAM OF RAS MUTANTS%REACTOME%R-HSA-9649948.2 Signaling downstream of RAS mutants 673 8826 2244 2266 7414 8844 10256 54518 5894 22866 5906 4140 5908 7450 5037 2243 7094 1445 7529 369 283455 408 409 4893 4296 3845 808 5594 5595 3690 3674 815 6714 5604 816 5605 817 8315 818 5245 2335 3265 3717 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME DATABASE ID RELEASE 95%1474228 Degradation of the extracellular matrix 6696 2 7076 101 5045 682 5340 4312 6868 4313 1310 7373 136227 91522 63827 1634 1305 1303 3818 3914 3915 1308 3918 1307 84570 1511 1306 831 3909 3911 3912 84290 823 824 1991 826 7077 10893 9510 92291 5645 10753 222663 825 827 440854 9313 9507 726 5650 4320 4321 164656 11131 23473 5644 11132 1509 4319 56999 4316 5654 1508 4323 4324 4325 11096 4326 11095 102 4327 5663 7177 23385 170690 1299 1298 170692 85007 649 1504 147968 26254 50859 440387 176 3339 388743 1297 7093 7092 80274 8751 8754 999 960 1215 3817 4317 4318 1520 1514 1513 1515 4314 80781 4322 4811 836 64386 INTERLEUKIN-20 FAMILY SIGNALING%REACTOME%R-HSA-8854691.8 Interleukin-20 family signaling 3716 6776 7297 6772 5781 58985 3588 50616 163702 29949 116379 53833 6774 53832 55801 282617 282618 11009 282616 3718 6775 6777 50604 6773 3717 INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME%R-HSA-9006925.5 Intracellular signaling by second messengers 113 114 115 107 108 23186 109 196883 5566 5567 5568 5928 3710 5153 1958 5931 2931 930 5136 3708 3709 1108 57504 9112 5156 5573 5575 5576 5577 5613 5978 1386 3815 1839 7409 57459 4233 572 3065 4615 1026 5879 389541 28956 2308 57521 55004 8649 4343 192669 55615 10670 6009 23112 27327 5305 26523 6591 192670 64121 27161 64223 57690 23396 5580 153129 9861 81847 6233 84335 3654 2475 7249 58528 10542 10325 7316 146850 8658 5294 5578 2100 23533 79837 10213 4193 5706 5707 5708 2064 5709 207 5700 5701 5702 5728 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 3164 1460 11047 5581 5582 5713 156 1459 5714 23252 3838 5137 5690 10645 5691 1457 10768 5692 26960 5693 84254 5694 7311 5293 5695 7314 4303 5687 5688 5689 331 842 79109 2146 90865 9173 6446 10014 5371 940 80351 7189 7157 80243 7874 118788 8975 23608 23035 5987 4734 941 2444 942 2122 1822 84232 5880 23239 8394 8726 6199 7101 8395 50852 8870 57167 253260 5468 1950 5335 1956 53615 2099 1027 5781 27006 8503 117145 3630 2549 10273 5159 11060 8660 9542 10718 145957 5594 5595 10818 208 3643 8817 26281 6615 391 9965 1147 2254 2252 51135 2251 8074 54815 2249 23028 2248 2247 57761 2246 2323 2322 152831 8823 51564 5295 5296 8841 2264 5519 5290 8535 5291 5170 6045 2255 1107 9846 3667 648 6015 23466 5515 3066 5516 808 1912 5518 1911 23512 3084 80012 57332 84733 5525 5526 815 2932 5527 5528 5529 6714 816 817 818 9219 6801 8396 374 2534 3932 3082 7979 814 4915 4909 627 7039 685 5155 255324 2069 10000 2309 3725 111 4916 112 4908 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 95%421270 Cell-cell junction organization 5928 1785 9069 23562 9080 53842 137075 51208 5010 24146 9073 5931 9071 9076 149461 9074 9075 26285 1366 1365 1364 49861 84552 10686 288 5584 29954 10585 283 221935 54549 1508 7841 7088 3065 1650 100128731 1499 6185 6184 23193 58505 821 5589 746 1603 3703 4609 4343 192669 23112 27327 999 26523 6591 4613 192670 116092 27161 7020 3170 94234 57690 23396 93986 9861 6929 55810 6233 687 79872 7750 348262 10009 7316 10213 9743 4193 5706 6938 5707 5708 5709 5700 5701 5702 1520 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 1460 11047 5713 5315 1459 5714 5690 5691 1457 5692 5693 5694 7311 5695 7314 5687 5688 5817 5819 5689 23411 9789 23478 60559 5045 2146 28972 5046 90701 283106 9159 64398 81607 27085 5818 57863 1013 23705 1010 1008 1007 1003 8726 1005 1004 1001 1002 1016 1015 1012 253559 50855 25945 1488 1487 7122 50848 5925 8970 3728 8331 56288 8337 128312 8334 9314 8335 6597 8370 55766 54971 8968 8341 8342 5594 8347 5595 28513 8348 2294 7764 117581 94239 80149 8345 56978 3013 9839 8728 8340 6663 1495 64403 8338 27319 80332 255626 1006 1500 3224 3021 3609 653604 6615 3018 1009 3017 85236 3014 8349 474382 54145 2060 1000 23028 6935 8289 387893 84612 3066 10207 23512 92359 6714 7414 54737 7291 10399 1514 6667 7490 7979 60436 11171 26508 51129 RESOLUTION OF D-LOOP STRUCTURES%REACTOME%R-HSA-5693537.3 Resolution of D-Loop Structures 348654 146956 197342 84464 23514 80198 79008 7486 116028 472 10635 672 675 83990 63979 51750 7516 10111 5932 7517 7979 4361 7156 5890 9156 5892 4683 55732 580 10524 641 1763 79728 5888 80010 5889 DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%5609975 Diseases associated with glycosylation precursor biosynthesis 116150 5373 2592 2673 8813 2584 2582 130589 54344 8818 79947 4351 22845 79644 5236 10020 POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME%R-HSA-426496.6 Post-transcriptional silencing by small RNAs 192669 23112 27327 26523 192670 27161 57690 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO ATRX MUTATIONS%REACTOME%R-HSA-9670615.2 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations 1616 546 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 95%418597 G alpha (z) signalling events 113 114 115 6004 107 108 55970 109 196883 5583 54331 59345 2793 2781 2792 346562 2791 5581 26575 5582 2790 5579 2788 2782 2787 5999 2786 2785 2784 5580 2783 8601 51764 10681 10287 150 151 152 353299 2778 2771 2770 5578 94235 5588 111 112 2773 ACYL CHAIN REMODELLING OF PG%REACTOME%R-HSA-1482925.3 Acyl chain remodelling of PG 22925 5321 79888 9926 255189 64600 254531 8399 26279 100137049 54675 30814 5322 81579 283748 5320 50487 5319 PERVASIVE DEVELOPMENTAL DISORDERS%REACTOME DATABASE ID RELEASE 95%9005895 Pervasive developmental disorders 2874 79718 3065 25942 9612 814 808 8841 9611 5566 6907 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 95%416572 Sema4D induced cell migration and growth-cone collapse 2064 23365 9475 10398 27289 6093 4628 79784 4629 10507 9826 3984 3985 103910 387 4637 4627 388 389 5364 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%R-HSA-199418.5 Negative regulation of the PI3K AKT network 90865 9173 940 7189 930 118788 23035 941 942 5880 8394 23239 8395 50852 8870 1950 1956 2099 5156 5781 27006 8503 117145 3630 2549 5159 8660 9542 10718 145957 5594 5595 3815 10818 208 3643 8817 26281 7409 1839 391 9965 2254 2252 51135 2251 4233 8074 2249 2248 4615 2247 57761 2246 2323 2322 152831 5879 8823 5295 5296 2264 5519 5290 5291 2255 9846 3667 5305 5515 5516 5518 23396 3084 3654 5525 5526 5527 5528 146850 5529 5294 6714 2100 23533 79837 2064 6801 207 5728 8396 374 2534 3932 3082 5293 4915 4909 627 7039 685 5155 255324 2069 10000 4916 4908 BDNF ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 95%9024909 BDNF activates NTRK2 (TRKB) signaling 4915 627 FRUCTOSE METABOLISM%REACTOME%R-HSA-5652084.8 Fructose metabolism 3795 229 231 216 26007 6652 132158 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME DATABASE ID RELEASE 95%9630750 Evasion of Oncogene Induced Senescence Due to p16INK4A Defects 1029 1021 1019 ASL VARIANTS CAUSE ARGININOSUCCINATE ACIDURIA%REACTOME%R-HSA-9956529.1 ASL variants cause argininosuccinate aciduria 435 KINESINS%REACTOME%R-HSA-983189.5 Kinesins 3831 23095 10749 55614 11127 146909 81930 84643 55582 3796 23303 124602 56992 1062 64147 9371 221458 9493 547 10112 29127 11004 55083 3798 3799 113220 9585 3797 3832 3833 23046 3834 24137 3835 64837 90990 26153 55605 89953 285643 147700 22920 MITOCHONDRIAL SHORT-CHAIN ENOYL-COA HYDRATASE DEFICIENCY 1%REACTOME DATABASE ID RELEASE 95%9916720 Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 1892 NFE2L2 REGULATING ANTI-OXIDANT DETOXIFICATION ENZYMES%REACTOME%R-HSA-9818027.3 NFE2L2 regulating anti-oxidant detoxification enzymes 7296 2033 2938 1728 2940 2730 5052 84181 6649 2729 7295 23657 571 3162 4780 468 140809 1387 7975 SIGNALING BY FGFR1 IN DISEASE%REACTOME%R-HSA-5655302.4 Signaling by FGFR1 in disease 2251 8074 5335 6776 2249 399687 2247 2246 11116 8805 5295 6772 4893 5290 1523 9846 2549 11052 613 9208 11160 10818 7750 26127 6774 26281 2260 6654 9530 2254 6777 3265 SYNTHESIS OF PC%REACTOME%R-HSA-1483191.7 Synthesis of PC 590 56910 57153 64900 126969 9468 10809 84879 58488 23175 1460 1459 1457 1103 80736 204962 79888 1120 23446 56994 43 5130 162466 1119 171586 10400 9663 10390 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO LRAT LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9918442 Defective visual phototransduction due to LRAT loss of function 9227 5947 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 95%5654221 Phospholipase C-mediated cascade; FGFR2 2252 27006 2255 2251 8074 5335 2249 2248 2247 2246 8823 8817 26281 2254 CPS1 VARIANTS CAUSE CPS1 DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9955542 CPS1 variants cause CPS1 deficiency 1373 TOXICITY OF BOTULINUM TOXIN TYPE A (BOTA)%REACTOME%R-HSA-5250968.4 Toxicity of botulinum toxin type A (botA) 22987 6616 9899 9900 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%R-HSA-997272.3 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits 3772 55970 3762 3763 3765 3766 3768 54331 59345 2793 2792 3773 2791 2790 2788 2782 2787 2786 2785 2784 2783 51764 10681 9568 94235 3760 3761 2550 3759 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 95%159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 26097 7919 10482 10921 10250 11338 8563 2733 8683 4116 9775 6430 6432 6431 55110 22794 9785 6427 29107 6426 9939 6429 199746 10212 84248 6428 728343 348995 9883 6396 129401 9688 57122 51213 23225 10189 4927 65109 23165 8021 55746 55706 23636 9631 7175 9972 11097 23279 8086 23511 53371 8480 79023 79902 10762 9295 5903 10569 22916 4686 79228 7307 51362 9984 57187 84324 84271 84321 9877 80145 DEGRADATION OF CDH1%REACTOME DATABASE ID RELEASE 95%9766229 Degradation of CDH1 2060 1499 1785 999 9861 6233 79872 27085 7316 6714 10213 4193 5706 5707 5708 5709 5700 5701 5702 1520 5704 5705 5682 5683 5684 5685 5686 10399 5717 1514 5718 3728 5719 11047 5713 5714 5690 5691 5692 5693 54971 5694 7311 7979 5695 7314 5687 5688 5689 1495 1500 1508 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME DATABASE ID RELEASE 95%3371598 Defective BTD causes biotidinase deficiency 686 LEISHMANIA INFECTION%REACTOME DATABASE ID RELEASE 95%9658195 Leishmania infection 113 114 718 115 5045 10006 107 108 55970 109 196883 60 5025 5566 5567 5568 10800 2268 9844 54331 6868 3710 59345 4627 5027 2782 64174 7454 7456 10681 1398 719 2778 3708 147179 3709 25 79792 4690 1511 3552 5335 3553 5970 4650 10769 644150 2209 1855 5573 5575 8976 5576 5577 5613 998 1857 1856 5594 4210 5595 3569 10910 4907 953 10451 957 7410 9051 3606 7409 26999 3326 5599 10810 4644 5879 79651 136 9332 2781 346562 2212 63916 29108 71 808 10109 1793 10552 10093 10092 10095 4067 10094 10097 695 10096 2771 3162 2770 4791 2773 10811 2678 2687 1535 10458 51517 55845 7295 114548 917 3586 834 2793 2792 2534 8936 4651 6850 1432 2791 4620 3055 10787 4641 2790 2214 10152 2788 10628 124056 10768 2787 2786 2785 1800 2784 4790 2783 51764 3071 57105 10163 5747 7474 8324 7525 94235 3725 23191 5336 111 112 27035 RHO GTPASES ACTIVATE ROCKS%REACTOME%R-HSA-5627117.5 RHO GTPases Activate ROCKs 9475 4660 10398 1072 6093 4628 79784 5058 4629 5500 3984 3985 103910 4659 387 4637 4627 388 389 DEFECTIVE SLC5A7 CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5658471.4 Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) 60482 ACTIVATION OF IRF3, IRF7 MEDIATED BY TBK1, IKKΕ (IKBKE)%REACTOME%R-HSA-936964.6 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 3661 29110 7311 7314 23643 7099 6233 353376 10133 10010 9641 3665 7316 929 7187 5781 148022 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2122947.6 NOTCH1 Intracellular Domain Regulates Transcription 7088 7089 3065 83933 10013 7091 10014 6907 79718 9734 51564 9612 8841 9794 9611 2648 23493 1387 3516 892 4609 2033 26960 1024 3066 7311 9759 7314 84441 8454 23462 8850 6233 3280 9978 10046 3091 79885 4851 7316 55869 26508 6500 388585 22938 55534 PKMTS METHYLATE HISTONE LYSINES%REACTOME DATABASE ID RELEASE 95%3214841 PKMTs methylate histone lysines 56979 2146 9757 84661 63976 83852 11091 7468 79918 5970 51111 64324 5928 5929 79813 55870 55729 10919 58508 84193 4297 79723 121536 29072 9869 84787 8370 80854 387893 54904 8968 5931 4790 9739 23512 9070 84444 56950 2122 8726 6839 653604 8085 4791 64754 23067 METHIONINE SALVAGE PATHWAY%REACTOME DATABASE ID RELEASE 95%1237112 Methionine salvage pathway 58478 51074 84245 55256 4507 2805 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME%R-HSA-6796648.5 TP53 Regulates Transcription of DNA Repair Genes 4436 9656 51755 905 2177 2176 7157 4292 8812 1643 5395 6921 55215 6923 5440 5441 4331 1022 2071 2966 6829 2965 2963 2962 2068 5434 5435 5436 5437 5438 5439 2968 8178 2967 404672 5430 25920 5431 5432 51224 5433 6924 7936 902 6827 6749 9150 6917 472 1025 51497 672 7469 11198 904 1111 1386 8621 5892 2353 545 3725 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME%R-HSA-72695.4 Formation of the ternary complex, and subsequently, the 43S complex 8894 8662 1965 8663 8661 8666 8667 8664 1968 8665 27335 3646 51386 8668 8669 10480 1964 6233 6230 6232 6210 6231 6234 6235 6191 2197 6193 6192 6194 51065 140032 6205 6227 6204 6207 6229 6206 6228 6209 6208 6188 6187 6223 6201 6189 6222 6203 6224 6202 6218 6217 3921 COMMON PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 95%140875 Common Pathway of Fibrin Clot Formation 2147 2244 2266 3053 2153 5624 5627 5197 2243 57126 2165 7056 462 2149 2162 5270 2157 5196 5104 10544 2159 5657 RAB GERANYLGERANYLATION%REACTOME%R-HSA-8873719.4 RAB geranylgeranylation 51715 326624 10890 339122 57403 5873 401409 10966 55647 401258 25837 9545 11031 5874 5870 115273 51762 23682 51560 142684 347517 9230 8766 5869 22931 83871 51209 9363 57111 5878 9367 338382 8073 1121 201475 1122 11021 7879 115827 5864 64284 5867 5872 57799 116442 5868 5865 23011 376267 10981 4218 54734 83452 84932 8934 27314 53916 53917 9609 81876 5861 5862 51552 5875 5876 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9909438 3-Methylcrotonyl-CoA carboxylase deficiency 64087 56922 MISCELLANEOUS SUBSTRATES%REACTOME%R-HSA-211958.5 Miscellaneous substrates 57834 113612 64816 1565 8529 284541 1580 54905 4051 126410 1579 29785 BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME DATABASE ID RELEASE 95%9026286 Biosynthesis of DPAn-3-derived protectins and resolvins 246 240 RHOQ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013406 RHOQ GTPase cycle 11135 8874 9322 1080 57120 55004 9497 23048 26030 115703 2697 2040 8773 6510 2909 9743 57584 392 9341 394 5062 8826 9815 7879 10298 23433 55240 81839 23092 54438 3728 144402 85360 8976 8476 998 23580 143098 10395 10435 11060 57580 4983 9578 857 23513 55789 10602 128239 23380 7037 5058 28964 23229 200894 81624 6453 55114 SIGNALING BY FGFR3 FUSIONS IN CANCER%REACTOME%R-HSA-8853334.5 Signaling by FGFR3 fusions in cancer 2261 IGF1R SIGNALING CASCADE%REACTOME DATABASE ID RELEASE 95%2428924 IGF1R signaling cascade 2252 2251 8074 2249 2248 2247 57761 2246 2323 2322 152831 8823 5295 5296 5140 2264 5781 4893 5290 5291 5170 27006 2255 117145 9846 54106 3667 2549 3481 8660 3479 30849 10818 8471 3480 208 8817 26281 9965 5289 6654 2254 3265 TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6782315.9 tRNA modification in the nucleus and cytosol 54482 129450 24140 60487 54802 54888 54920 10785 4234 8270 55621 152992 63892 348180 2058 83480 113179 79691 55644 81890 84520 51605 93587 90353 221078 23536 1787 54974 84267 57604 51504 54901 134637 81605 51002 112858 91801 54517 55253 55039 9836 115708 57570 127253 ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS%REACTOME%R-HSA-380994.5 ATF4 activates genes in response to endoplasmic reticulum stress 51010 167227 6347 51013 118460 1054 1051 22894 440 467 468 56915 1649 3576 4800 11340 4801 8570 4802 23404 9709 54512 22926 5393 23016 3484 5073 GAB1 SIGNALOSOME%REACTOME%R-HSA-180292.5 GAB1 signalosome 1950 2549 1956 55824 7039 1445 685 255324 5829 2069 5295 6714 374 1839 5781 5290 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME DATABASE ID RELEASE 95%2644607 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 9978 4851 6500 8454 ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 95%2161517 Abacavir transmembrane transport 5243 6580 6581 9429 6582 G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME%R-HSA-418217.5 G beta:gamma signalling through PLC beta 2782 2788 2787 2786 55970 2785 2784 5330 2783 5331 51764 10681 23236 54331 59345 94235 2793 2792 2791 2790 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 95%69615 G1 S DNA Damage Checkpoints 1029 993 1017 1026 7157 9861 6233 25946 9978 2932 7316 1452 11200 10213 64326 4194 8945 79858 4193 1454 5706 5707 5708 5709 5700 1263 5701 5702 898 5704 5705 5682 23291 5683 9134 5684 1027 5685 5686 5717 5718 472 5719 1432 11047 1111 5713 5714 5690 5691 5692 5693 5694 57060 7311 7979 5695 7314 8454 51230 5687 5688 5600 5689 890 8900 6500 LOSS OF FUNCTION OF KMT2D IN KABUKI SYNDROME%REACTOME DATABASE ID RELEASE 95%9944971 Loss of Function of KMT2D in Kabuki Syndrome 5929 84661 11091 8085 9070 BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME DATABASE ID RELEASE 95%77285 Beta oxidation of myristoyl-CoA to lauroyl-CoA 3030 33 3032 SYNTHESIS AND PROCESSING OF GAG, GAGPOL POLYPROTEINS%REACTOME DATABASE ID RELEASE 95%174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins 7311 7314 55048 89853 6233 137492 51271 51160 155382 93343 7251 79720 7316 9397 SIGNALING BY MAP2K MUTANTS%REACTOME%R-HSA-9652169.2 Signaling by MAP2K mutants 5604 5594 5605 5595 PARASITE INFECTION%REACTOME%R-HSA-9664407.3 Parasite infection 10006 60 10810 2268 9844 4644 5879 4627 63916 71 7454 7456 10109 1398 1793 10552 10093 10092 10095 4067 10094 10097 695 10096 147179 25 4690 10458 51517 55845 4650 644150 917 2534 4651 8976 8936 6850 3055 4620 10787 4641 2214 10152 998 5594 5595 10451 7410 3071 10163 5747 7525 7409 23191 26999 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME%R-HSA-9632700.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 1029 1021 1019 RNA POLYMERASE II HIV PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 95%167162 RNA Polymerase II HIV Promoter Escape 2071 2966 2965 83860 2963 2962 8148 2068 5434 6872 5435 5436 51616 6874 5437 6873 5438 5439 2968 2967 404672 6881 5430 5431 138474 54457 5432 5433 6908 902 6880 6883 2961 2960 6882 6884 2959 2958 129685 2957 6875 6878 6877 6879 5440 5441 4331 1022 REGULATION OF PAK-2P34 ACTIVITY BY PS-GAP RHG10%REACTOME DATABASE ID RELEASE 95%211728 Regulation of PAK-2p34 activity by PS-GAP RHG10 79658 5062 ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME DATABASE ID RELEASE 95%9032500 Activated NTRK2 signals through FYN 5879 2904 6714 4915 627 1795 MRNA SPLICING%REACTOME DATABASE ID RELEASE 95%72172 mRNA Splicing 4904 10915 10594 7737 10236 11325 55749 27238 63932 9130 10921 11338 4236 79706 57819 4116 84081 6430 25949 6432 6431 79171 1660 22794 8175 23524 1655 4809 10450 6427 91603 6426 9939 6429 57703 6428 1659 23658 51729 5356 55094 27336 27339 79165 1665 26121 84991 10465 163859 25804 3181 3188 65109 3187 3185 3184 79753 55660 2521 7536 9716 51503 51747 3192 3191 23517 3190 23759 9295 10569 79622 83443 51634 7307 51759 3178 7919 3312 5440 5441 2963 2962 5434 5435 5436 5437 5438 5439 5430 5431 5432 5433 6434 10250 27316 3183 51428 51639 53938 8896 11066 51645 10772 11193 24148 55696 24144 8899 55100 85437 23020 85313 143884 10992 9879 9410 10081 8683 10084 9775 23398 9092 3550 22985 55234 55110 55599 8559 5725 58509 10523 6936 9785 10291 59286 79576 199746 9416 8449 10179 58517 10181 51690 51691 57794 11157 10189 8233 4670 22938 151903 51340 10713 5511 55702 22826 22827 10284 5411 10283 153527 8241 5093 5094 60625 84811 22916 51593 23350 4686 10286 10285 988 55954 11017 9584 9343 6632 154007 6631 10929 57461 84844 56259 51362 6625 6627 6626 6629 135295 6628 220988 10262 27258 84950 10946 23450 23451 54883 6634 56949 6633 6636 5546 6635 6638 6637 9128 9129 10907 26017 9360 DEPOLYMERIZATION OF THE NUCLEAR LAMINA%REACTOME%R-HSA-4419969.4 Depolymerization of the Nuclear Lamina 5579 2010 23175 255919 5578 4001 9663 891 23592 221496 983 64900 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME DATABASE ID RELEASE 95%3304347 Loss of Function of SMAD4 in Cancer 4087 4088 4089 OAS ANTIVIRAL RESPONSE%REACTOME DATABASE ID RELEASE 95%8983711 OAS antiviral response 2316 6059 23586 201626 6041 4938 4940 8638 4939 PD-L1(CD274) GLYCOSYLATION AND TRANSLOCATION TO PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 95%9931295 PD-L1(CD274) glycosylation and translocation to plasma membrane 3716 1650 5133 100128731 6185 10331 7991 80380 6184 58505 201595 142678 746 1603 84061 3703 29126 RHO GTPASES ACTIVATE KTN1%REACTOME%R-HSA-5625970.2 RHO GTPases activate KTN1 998 5879 3831 64837 3798 387 3799 391 89953 3895 147700 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 95%163125 Post-translational modification: synthesis of GPI-anchored proteins 80235 9487 9488 146760 7070 50863 84628 646627 257194 1368 1048 8875 58530 284348 154064 390243 7512 266727 2215 94005 353091 80055 8733 137797 10026 128869 55650 51604 51299 23627 4045 116372 4062 8434 171169 54965 51227 8000 54742 123904 84720 2350 10942 147719 83639 84992 8813 4978 22854 503542 27076 8818 4061 248 1043 80328 6975 146183 54872 161357 1087 419 23556 420 349667 284098 5329 80740 349633 53942 152330 5277 54344 338328 5279 249 10232 5283 130576 683 251 5281 4241 5067 93183 8581 7007 8876 360226 135228 2813 2822 GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 95%190873 Gap junction degradation 1213 1601 1211 1173 1785 8218 2697 1759 1212 4646 ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS%REACTOME%R-HSA-5617472.4 Activation of anterior HOX genes in hindbrain development during early embryogenesis 5915 5914 5916 474382 2146 9125 84661 54145 11091 5928 5929 8841 9611 1959 23054 22976 5931 8202 23512 9070 84962 7703 3199 8726 79447 8085 5440 5441 57472 7528 5434 5435 5436 5437 5438 5439 5430 5431 5432 5433 58508 8970 8331 8337 128312 1387 8334 8335 2033 8370 55766 8968 8341 8342 8347 8348 94239 4211 8345 3200 3013 9063 5087 9935 8340 3211 3201 7403 8338 10664 255626 3221 6256 63925 3214 3021 3213 653604 3212 3725 3018 5316 3017 3233 85236 3232 3014 3198 3231 5080 8349 METABOLISM OF NITRIC OXIDE: NOS3 ACTIVATION AND REGULATION%REACTOME DATABASE ID RELEASE 95%202131 Metabolism of nitric oxide: NOS3 activation and regulation 3320 23576 114757 10434 115677 340481 6697 207 808 857 1785 80777 4846 4836 51070 8976 9397