PROTEASOME DEGRADATION%WIKIPATHWAYS_20260510%WP302%RATTUS NORVEGICUS Proteasome degradation Psmc6 Psmc5 Psma5 Psmc2 Rpn2 Psma2 Psmc4 Psmc3 Rpn1 Psme2 Psme1 Psmd12 Psmd11 Ube2b Psmd13 Psmb9 Uchl3 Psmb8 Psmb6l1 Psmb5 Psmd7 Psmd6 Psmb4 Psmb7 Psmd8 Uchl1 Psmb1 Psmd3 Psmd2 Psmd5 Psmd4 Psmb2 Ube2d3 Ube2d1 Psma7 TCA CYCLE%WIKIPATHWAYS_20260510%WP347%RATTUS NORVEGICUS TCA cycle Idh3b Afdn Pdha1 Pc Suclg1 Suclg2 Pdk4 Pdk3 Ogdh Dld Pdk2 Fh Mdh1 Mdh2 Pdhb Sdhc Sdhb Sdha BETA OXIDATION META PATHWAY%WIKIPATHWAYS_20260510%WP372%RATTUS NORVEGICUS Beta oxidation meta pathway Dld Hadha Hadhb Lpl Pnpla2 Acadvl Acss2 Acat1 Gcdh Crat Tpi1 Acadm Cpt2 Acads Echs1 Cpt1a Acsl1 Lipe Gpd2 Lipf Acsl5 Acsl6 Acsl3 Acsl4 Hadh HEDGEHOG SIGNALING PATHWAY%WIKIPATHWAYS_20260510%WP574%RATTUS NORVEGICUS Hedgehog signaling pathway Ccnb1 Hhip Igf2 Gli1 Gli3 Gli2 Ski Crebbp Shh Ptch2 Smo Ptch1 Sufu Sap18 Dyrk1a Cdk1 OSTEOCLAST%WIKIPATHWAYS_20260510%WP489%RATTUS NORVEGICUS Osteoclast Ifnb1 Trpv5 Itgb3 Zcchc2 Ctsk Spp1 Tnfsf11 Slc9a1 Atp6v1e1 Ifnar1 HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP94%RATTUS NORVEGICUS Hepatocyte growth factor receptor signaling Pxn Mapk1 Elk1 Dock1 Mapk3 Crkl Pak1 Itga1 Ptpn11 Rap1a Jun Rap1b Pik3ca Hgf Gab1 Ptk2b Fos Pten Ptk2 Map4k1 Itgb1 Map2k2 Map2k1 Rapgef1 Stat3 Grb2 Raf1 Sos1 Met Crk Hras Mapk8 Src Rasa1 G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20260510%WP348%RATTUS NORVEGICUS G1 to S cell cycle control Rb1 Ccnd1 Rpa2 Cdk7 Cdk6 Wee1 Mdm2 E2f1 E2f2 E2f3 E2f4 Cdkn1a E2f5 Cdkn1b E2f6 Pole Cdkn1c Ccnb1 Cdk1 Ccna1 Mcm7 Ccne1 Ccne2 Mnat1 Necab3 Cdkn2b Tfdp1 Cdkn2c Tp53 Cldn5 Creb3 Pcna Ccnh Myt1 Rbl1 Mcm4 Mcm5 Mcm6 Mcm2 Pole2 Pola2 Ccng2 Creb3l4 Gadd45a Creb3l1 Orc5 Rpa3l1 Orc4 Orc6 Orc1 Atf6b Orc3 ONE CARBON METABOLISM%WIKIPATHWAYS_20260510%WP1292%RATTUS NORVEGICUS One carbon metabolism Mat1a Gart Mthfr Mthfd1l Ahcy Folh1 Mtrr Mtr Dnmt3b Mthfd2 Ftcd Dhfr Ahcyl2 Bhmt Tcn2 Dnmt3a Aldh1l1 Shmt1 REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20260510%WP351%RATTUS NORVEGICUS Regulation of actin cytoskeleton Tmsb4x Arhgap35 Wasf2 Gsn Wasf1 Egf Mos Apc Limk1 Rock1 Pip5k1b Pip5k1a Slc9a1 Pxn Mapk1 Dock1 Mapk3 Pak1 Itga1 Pik3ca Ptk2 Map2k1 Raf1 Sos1 Crk Ins1 Ins2 Fgf2 Fgf1 Fgf4 Fgf3 Mapk4 Fgf6 Fgf5 Fgf8 Fgf7 Fgf9 Cfl1 Cfl2 Egfr Actb Nras Pip4k2b Pfn1 Ezr Vcl Pip4k2a Arhgef7 Arhgef6 Arhgef1 F2r Myh10 Chrm1 Chrm3 Nckap1 Chrm2 Chrm5 Chrm4 Pdgfrb Pdgfra Pdgfa Rras2 Pik3cg Actg1 Pik3cd Pik3c2b Pik3c2a Ssh3 Fgfr3 Pik3c2g Ssh2 Fgfr4 Ssh1 Fgfr1 Fgfr2 Mylk Cyfip2 Arpc5 Cd14 Gng12 Fgf16 Fgf17 Fgf14 Fgf18 Fgf19 Braf Fgf12 Fgf13 Pik3c3 Fgf10 Rhoa Fgf11 Enah Iqgap1 Rac1 Baiap2 Git1 Fgf20 F2 Fgf23 Rras Pik3r5 Rassf7 Sos2 Pik3r1 Pik3r2 Pik3r3 Gna12 Gna13 Fgd1 Bcar1 Pak6 Csk Pak3 Pak2 Pak5 Pak4 Cdc42 ANGIOTENSIN II SIGNALING ACUTE IN THICK ASCENDING LIMBS%WIKIPATHWAYS_20260510%WP3887%RATTUS NORVEGICUS Angiotensin II signaling acute in thick ascending limbs Calm2 Pdpk1 Akt3 Pde2a Gnaq Akt2 Pten Arrb2 Agtr1a Akt1 Agtr1b Nos3 Plcg1 Agtr2 Prkaca Plcg2 Dnm1 Prkcg Mas1 Nox4 Prkca Itpr3 Itpr2 Itpr1 Agtrap P53 PATHWAY%WIKIPATHWAYS_20260510%WP655%RATTUS NORVEGICUS p53 pathway Cdk6 Cdkn1a Pten Ccne1 Ccnb1 Sesn1 Ccng1 Chek1 Chek2 Zmat3 Tp53 Igfbp3 Serpinb5 Cdkn2a Bid Shisa5 Tp73 Sfnl1 Adgrb1 Casp9 Cd82 Cdk1 Casp3 Cycs Tsc2 Perp Gadd45a Siah1 Pmaip1 Bax Fas Serpine1 Mdm4 Ppm1d Rchy1 Rprm ETHANOL METABOLISM RESULTING IN PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20260510%WP4268%RATTUS NORVEGICUS Ethanol metabolism resulting in production of ROS by CYP2E1 Mafg Prkcb Cyp2e1 Nfe2l2 Map2k1 Mapk8 ERBB SIGNALING PATHWAY%WIKIPATHWAYS_20260510%WP1299%RATTUS NORVEGICUS ErbB signaling pathway Mapk1 Elk1 Shc2 Erbb2 Egf Eif4ebp1 Map2k7 Ereg Hbegf Mtor Jun Rps6kb1 Cdkn1a Camk2a Abl1 Cdkn1b Akt3 Bad Gab1 Tgfa Cblc Nrg2 Nrg1 Ptk2 Btc Gsk3b Stat5a Map2k1 Nrg4 Plcg1 Nrg3 Grb2 Sos1 Crk Hras Prkca Pik3r5 Egfr Mapk8 Src Pak4 PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20260510%WP303%RATTUS NORVEGICUS Prostaglandin synthesis and regulation Ednrb Anxa8 Ednra Anxa6 Pla2g4a Prl Ptgdr Ptgds Ptger4 Ptgfr Ptger2 Ptger3 Cyp11a1 Ptger1 S100a6 Scgb1a1 Hsd11b1 Hsd11b2 Tbxas1 Edn1 Hpgd Ptgis Ptgir Anxa5 Anxa4 Anxa3 S100a10 Ptgs1 Anxa1 Ptgs2 GPCRS OTHER%WIKIPATHWAYS_20260510%WP409%RATTUS NORVEGICUS GPCRs other Grm8 Htr2a Gpr61 Or1n1 Ccr5 Ccr2 Gpr176 Adra1d Cckbr Alg6 Adgrl2 Adgrl3 Gpr135 Sstr2 Htr1f Taar3 Rxfp3 Taar2 Rxfp1 Taar5 Ghrhr Gpr183 C5ar2 Or3a1e Or2a5 Hrh4 Gpr88 Or2f1 S1pr1 Drd3 Drd4 Celsr2 Cnr1 Gpr18 Grpr Uts2r P2ry13 Gpr17 Or10a5 Ltb4r2 Lgr6 Or10a2 Smo F2r Chrm3 Chrm2 Ednra Ptgfr Prokr2 Adora2a Gpr162 Adgrg1 Cxcr1 Gnrhr Ntsr1 Grm1 Htr7 Fshr MRNA PROCESSING%WIKIPATHWAYS_20260510%WP529%RATTUS NORVEGICUS mRNA processing Celf2 Pabpn1 Celf1 Snrpd3 Sf3b2 Sf3b3 Sf3b4 Rbm39 Sfswap Sf3b5 Srp54 Hnrnph2 Ppm1g Hnrnph1 Dicer1 Ddx20 Rngtt Smc1a Prpf4 Phf5a Prpf6 Prpf3 Prpf40a Scamp3 Hnrnpa2b1 Supt5h Cdc40 Rnmt Snrnp70 Clp1 Snrpb2 Xrn2 Spop Prpf8 Snrnp40 Prpf18 Dhx8 Hnrnpr Dhx9 Hnrnpu Papola Snrpb Snrpa1 Snrpa Clk2 Clk3 Clk4 Mettl3 Prp4k Ptbp1 Fus Sugp1 Sugp2 Srpk1 Cpsf4 Lsm7 Cpsf1 Hnrnpd Cpsf2 Cpsf3 Ddx1 Snrpepl2 Hnrnpk Hnrnpm Hnrnpab Cstf1 Ybx1 Clasrp Nudt21 Tmed10 Sfpq Prmt1 Prmt2 Cstf2 Dhx16 Cstf3 Dhx15 Srsf1 Ptbp2 Srsf9 Srsf7 Srsf6 Srsf5 Srsf4 Srsf3 Srsf2 Srek1 Srsf10 Srrm1 Rbm17 Linc00176 U2af1 Nxf1 Sf3a1 Sf3a2 Sf3a3 U2af2 Ncbp2 Ncbp1 Cd2bp2 Rbmx Snrpd1 Tra2b Celf4 IL 9 SIGNALING PATHWAY%WIKIPATHWAYS_20260510%WP8%RATTUS NORVEGICUS IL 9 signaling pathway Mapk1 Mapk3 Ptpn11 Socs3 Pik3r1 Vcp Shc1 Akt1 Irs2 Stat5a Il2rg Map2k1 Stat5b Kat5 Stat3 Il9 Grb2 Jak3 Jak1 Il9r G PROTEIN SIGNALING PATHWAYS%WIKIPATHWAYS_20260510%WP73%RATTUS NORVEGICUS G protein signaling pathways Gnaq Prkaca Prkcg Plcb3 Prkd3 Pde7b Prkca Pde7a Adcy3 Akap7 Itpr1 Akap8 Adcy4 Adcy1 Adcy2 Adcy7 Akap3 Akap4 Adcy8 Akap1 Adcy5 Gnaz Adcy9 Akap10 Akap11 Akap12 Akap9 Akap13 Nras Pde4b Prkacb Prkcq Pde8a Pde8b Kcnj3 Prkci Slc9a1 Prkcd Arhgef1 Prkce Gnai1 Pakap Gnai3 Prkar1a Prkcb Gna14 Prkar1b Gnao1 Gng3 Gnal Gng5 Pde4c Pde4d Gnas Gng8 Prkcz Ppp3ca Gngt1 Ppp3cc Prkar2b Pde1c Gnb2 Pde1a Gnb1 Gnb3 Gng11 Gng13 Gng12 Hras Rhoa Rras Gna12 Gna13 TOLL LIKE RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260510%WP1309%RATTUS NORVEGICUS Toll like receptor signaling pathway Mapk13 Mapk14 Tollip Ripk1 Nfkbia Map2k4 Map2k3 Il1b Tab2 Chuk Mapk10 Akt3 Akt2 Akt1 Ifnb1 Spp1 Ifnar1 Mapk8 Mapk1 Mapk3 Map2k7 Pik3cg Pik3cd Jun Pik3ca Fos Map2k1 Mapk9 Ikbkb Cd14 Traf6 Il12b Ikbkg Il12a Map3k8 Map3k7 Ikbke Tnf Ticam2 Nfkb2 Nfkb1 Lbp Cd86 Cd40 Cd80 Rac1 Rela Ly96 Tlr1 Ifna4 Irf3 Ifna1 Irf7 Pik3r5 Tlr8 Irf5 Fadd Tlr7 Pik3r1 Tlr6 Pik3r2 Tlr5 Pik3r3 Tlr4 Tlr3 Tlr2 Cxcl11 Cxcl10 Map2k6 Il6 Cxcl9 Ccl5 Ccl4 Ccl3 NOD LIKE RECEPTOR NLR SIGNALING PATHWAY%WIKIPATHWAYS_20260510%WP1294%RATTUS NORVEGICUS Nod like receptor NLR signaling pathway Cd40 Ikbkb Rela Chuk Ikbkg Ephb2 Mapk8 Map3k7 FATTY ACID OMEGA OXIDATION%WIKIPATHWAYS_20260510%WP133%RATTUS NORVEGICUS Fatty acid omega oxidation Cyp1a1 Cyp4a2 Cyp2e1 Cyp3a2 Adh7 Adh6 Acad10 Adh5 Adh4 Aldh1a1 Adh1 Aldh2 GLUTATHIONE METABOLISM%WIKIPATHWAYS_20260510%WP469%RATTUS NORVEGICUS Glutathione metabolism Gstm3 Gstm2 Gstt2 Gstt1 Gclm Ggt1 Oplah Ggt5 G6pd Gpx2 Gpx3 Gss Gsr Anpep Gstm5l Gstm6 IL 2 SIGNALING PATHWAY%WIKIPATHWAYS_20260510%WP569%RATTUS NORVEGICUS IL 2 signaling pathway Mapk14 Chuk Socs3 Akt1 Shc1 Irs2 Il2rg Stat5b Jak3 Jak1 Socs1 Il2ra Plcb1 Ets2 Jak2 Foxo3 Stam2 Syk Rack1 Gab2 Eif4e Tert Lck Cd53 Nr3c1 Ptpn6 Itm2b Stam Eif3b Il2 Fyn Lyn Mapk8 Mapkapk2 Nmi Mknk1 Mapk1 Mapk3 Crkl Ptpn11 Pik3cg Mtor Pik3cd Rps6kb1 Prkcz Pik3ca Ptk2b Stat5a Map2k1 Mapk9 Stat3 Grb2 Ybx1 Raf1 Sos1 Crk Nfkb1 Rela Pik3r1 Pik3r2 GLUCOCORTICOID METABOLISM%WIKIPATHWAYS_20260510%WP305%RATTUS NORVEGICUS Glucocorticoid metabolism Cyp21a1 Akr1c14 Cyp17a1 Cyp11a1 Hsd11b1 Hsd11b2 SYNTHESIS AND DEGRADATION OF KETONE BODIES%WIKIPATHWAYS_20260510%WP349%RATTUS NORVEGICUS Synthesis and degradation of ketone bodies Hmgcl Bdh1 Oxct1 Hmgcs2 OXIDATIVE STRESS RESPONSE%WIKIPATHWAYS_20260510%WP173%RATTUS NORVEGICUS Oxidative stress response Mapk14 Gstt2 Nfkb1 Nqo1 Nfix Hmox1 Sod3 Mapk10 Sod2 Sod1 Txn2 Txnrd2 Cyba Fos Cyp1a1 Cat Mgst1 Junb Xdh Gpx3 Gsr ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20260510%WP557%RATTUS NORVEGICUS ACE inhibitor pathway Ace Agtr1b Kng2l1 Nos3 Ren Bdkrb2 Agtr2 Kng2 Agt MIR219 IN OLIGODENDROCYTE DIFFERENTIATION AND MYELINATION%WIKIPATHWAYS_20260510%WP2811%RATTUS NORVEGICUS mir219 in oligodendrocyte differentiation and myelination Pdgfra Zbtb18 Foxj3 Elovl7 Neurod1 Sox6 Hes5 NUCLEOTIDE METABOLISM%WIKIPATHWAYS_20260510%WP146%RATTUS NORVEGICUS Nucleotide metabolism Pold1 Prps2 Polb Impdh1 Nme2 Hprt1 Polg Mthfd2 Adss2 Sat1 Dhfr Srm ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20260510%WP360%RATTUS NORVEGICUS Acetylcholine synthesis Pdha1 Ache Pcyt1a Ahsg Chat Pemt NUCLEAR FACTOR ERYTHROID DERIVED 2 LIKE 2 SIGNALING PATHWAY%WIKIPATHWAYS_20260510%WP2376%RATTUS NORVEGICUS Nuclear factor erythroid derived 2 like 2 signaling pathway Scarb1 Cdc34 Pmf1 Gstm5 Gstm4 Gstm1 Ubb Slc1a4 Mafk Actg2 Fosl1 Bach1 Dhcr7 Ephx1 Akr1a1 Slc35b1 Dnajc5 Aldh3a1 Ftl1 Vcp Xpo1 Gsto1 Mgst3 Gsto2 Slc2a1 Mgst2 Ugdh Cbr1 Ldhb Prkcg Gstp1 Pik3r6 Prkd3 Taldo1 Prkca Aldoa Dnajb4 Actc1 Nqo2 Fmo1 Akr1b10 Brca1 Usp14 Ran Crebbp Prkcq Prkci Prkcd Prkce Mapk8 Mafg Mapk1 Prkcb Nfe2l2 Mapk3 Map2k7 Jun Prkcz Pik3ca Gsk3b Map2k1 Mapk9 Raf1 Map3k7 Hras Tp53 Map2k6 Mapk14 Cdkn1a G6pd Gss Gsr Gstm5l Gstm6 Gstm3 Gstm2 Gstt2 Gstt1 Gclm Actb Nras Fyn Rras2 Nqo1 Hmox1 Actg1 Pik3cd Sod3 Pik3c2b Sod2 Pik3c2a Sod1 Pik3c2g Mgst1 Psmc6 Psmc5 Psmc2 Psmc4 Psmc3 Pik3c3 Rras Txn1 Pik3r5 Mapk7 Akr7a3 Akr7a2 Pik3r1 Eif2ak3 Pik3r2 Ube2k Pik3r3 Gstk1 Herpud1 Sqstm1 Fth1 Acta1 Acta2 Prdx1 Abcc3 Abcc4 Abcc1 Map3k1 P38 MAPK SIGNALING PATHWAY%WIKIPATHWAYS_20260510%WP294%RATTUS NORVEGICUS p38 Mapk signaling pathway Mapk14 Elk1 Ripk1 Map2k4 Shc1 Grb2 Pla2g4a Map3k7 Hras Atf2 Rac1 Max Map3k9 Mef2d Map3k5 Tgfb2 Tradd Hspb1 Traf2 Mapkapk5 Rps6ka5 Tgfbr1 Daxx Map2k6 Mapkapk2 Cdc42 Map3k1 Mknk1 FOLIC ACID NETWORK%WIKIPATHWAYS_20260510%WP1311%RATTUS NORVEGICUS Folic acid network Mt-co2 Selenok Mthfr Sod1 Ptgis Txnrd2 Cat Xdh Fads2 Mtr Mt-co1 Gpx1 Gpx6 Alox5 Gpx3 Msrb1 Selenow Gsr Kmo Tbxt Cbs Ptgds Pnpo NUCLEOTIDE GPCRS%WIKIPATHWAYS_20260510%WP502%RATTUS NORVEGICUS Nucleotide GPCRs Adora2b P2ry6 Lpar6 Adora1 P2ry2 Adora2a P2ry1 Lpar4 MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20260510%WP140%RATTUS NORVEGICUS Myometrial relaxation and contraction pathways Gnaq Arrb2 Gsto1 Nos3 Plcg1 Plcg2 Prkcg Plcb3 Prkca Itpr3 Adcy3 Actc1 Itpr1 Adcy4 Adcy1 Adcy2 Adcy7 Atf2 Igfbp3 Adcy5 Adcy9 Pde4b Prkacb Prkcq Prkcd Prkce Prkar1a Prkcb Prkar1b Gng3 Pde4d Prkd1 Rgs4 Jun Gng8 Rgs5 Prkcz Rgs2 Camk2a Gja1 Gngt1 Rgs3 Rgs1 Prkar2b Crcp Fos Slc8a1 Gnb2 Rgs9 Rgs6 Gnb1 Rgs7 Gnb3 Myl4 Mylk2 Gng13 Prkch Myl2 Rxfp2 Atf5 Atf3 Maff Pkib Calca Grk5 Grk4 Pkia Grk6 Pkig Nfkb1 Oxtr Gucy1a1 Dgkz Gnb4 Rln1 Ryr2 Atp2a3 Creb3 Atp2a2 Ywhaq Oxt Adm Ywhah Ywhag Gabpa Ywhae Ywhab Nos1 Guca2b Guca2a Crhr1 Lpar1 Cald1 Crh Il6 Rgs20 Camk2g Rgs17 Atf6b Camk2d Rgs19 Camk2b Gng2 Igfbp4 Vkorc1l1 Rgs14 Gng7 Igfbp1 Rgs16 Il1b Arrb1 Rgs10 Ackr5 Corin Ramp3 Rxfp1 Ets2 Actb Actg1 Gng12 Acta1 IL 6 SIGNALING PATHWAY%WIKIPATHWAYS_20260510%WP135%RATTUS NORVEGICUS IL 6 signaling pathway Rb1 Mapk14 Map2k4 Ppp2r3b Ppp2r3a Hsp90aa1 Map3k4 Ppp2r2c Socs3 Ppp2r2b Hdac1 Akt1 Foxo4 Shc1 Mapt Foxo1 Ppp2cb Plcg1 Stat5b Ppp2ca Cdk5r1 Fgr Jak1 Hck Ptpa Rps6ka2 Btk Sgk1 Il6st Nlk Ppp2r5c Cebpb Ppp2r5b Ppp2r5a Ncoa1 Tmem97 Il6r Inppl1 Ppp2r2a Crebbp Jak2 Eif2a Foxo3 Bmx Cdk9 Ppp2r1a Hspb1 Ppp2r5e Gab2 Tec Eif4e Casp9 Cdk5 Fes Casp3 Hnf1a Daxx Prkcd Fyn Lyn Mapk8 Mapkapk2 Pxn Mapk1 Mapk3 Erbb2 Eif4ebp1 Ptpn11 Jun Rps6kb1 Gab1 Bad Ptk2b Fos Ptk2 Gsk3b Map2k2 Stat5a Map2k1 Stat3 Grb2 Raf1 Sos1 Map3k7 Hras Nfkb1 Cd40 Rac1 Pik3r1 Pik3r2 Map2k6 Il6 MISMATCH REPAIR%WIKIPATHWAYS_20260510%WP1295%RATTUS NORVEGICUS Mismatch repair Pold1 Lig1 Msh2 Rfc1 Pcna S1P RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20260510%WP1312%RATTUS NORVEGICUS S1P receptor signal transduction Mapk1 Mapk3 Plcb1 Mapk4 Pik3c2b Akt3 Akt2 Akt1 Smpd2 Mapk12 Plcb2 Asah1 Sphk2 Sphk1 S1pr1 Plcb3 Gnai1 S1pr3 Gnai3 ACETATE MEDIATED PROMOTION OF METABOLIC SYNDROME%WIKIPATHWAYS_20260510%WP3650%RATTUS NORVEGICUS Acetate mediated promotion of metabolic syndrome Ins2 Gast LIPID DROPLET METABOLISM%WIKIPATHWAYS_20260510%WP3901%RATTUS NORVEGICUS Lipid droplet metabolism Lpin3 Acsl3 Aup1 Lipa Gpat2 Lpin1 Plin2 Bscl2 Dgat2 Agpat5 Dgat1 Agpat3 Fitm2 Agpat4 Agpat1 Pnpla2 Agpat2 Acsl1 Gpd2 Soat1 BETA OXIDATION OF UNSATURATED FATTY ACIDS%WIKIPATHWAYS_20260510%WP418%RATTUS NORVEGICUS Beta oxidation of unsaturated fatty acids Decr1 Acadm Hadha Hadhb Eci1 THICK ASCENDING LIMB TRANSPORTERS%WIKIPATHWAYS_20260510%WP3882%RATTUS NORVEGICUS Thick ascending limb transporters Car2 Slc4a7 Slc12a1 Atp1b1 Slc9a2 Slc9a3 Atp1a1 Aqp1 Kcnk12 Ca4 Kcnq1 Slc12a7 Kcnj16 Clcnkb Clcnka TNF ALPHA NF KB SIGNALING PATHWAY%WIKIPATHWAYS_20260510%WP457%RATTUS NORVEGICUS TNF alpha NF kB signaling pathway Glg1 Cdc34 Bag4 Ripk2 Ripk3 G3bp2 Dcaf7 Cops3 Nfkbib Cav1 Capn3 Kpna6 Mcc Kpna3 Kpna2 Dap Bcl3 Cul1 Akt2 Rel Ccar2 Traf4 Akt1 Pfdn2 Faf1 Csnk2a2 Csnk2a1 Tnfrsf8 Mark2 Prkaca Tnfrsf1b Hdac2 Tnfrsf1a Smarcb1 Alpl Rasal2 Csnk2b Rpl8l1 Cyld Akap8 Fkbp5 Tnip2 Tnip1 Pdcd2 Nsmaf Zfand5 Commd1 Crebbp Trpc4ap Casp7 Fancd2 Elp1 Tradd Casp2 Hspb1 Ktn1 Traf2 Pebp1 Pkn1 Lrpprc Casp3 Mtif2 Map3k14 Src Ptpn11 Rps6kb1 Prkcz Gab1 Ptk2 Gsk3b Ikbkb Traf6 Ikbkg Map3k8 Ikbke Tnf Mcm7 Nfkb2 Nfkb1 Rela Ywhah Ywhag Mcm5 Fadd Ywhae Ywhab Ripk1 Nfkbia Tab2 Chuk Hdac1 Ppp2ca Rack1 Psmc2 Kcnq1 Psmc3 Nkiras1 Nr2c2 Psmd12 Nkiras2 Tbkbp1 Rps11 Psmd13 Rpl6 Rps13 Pias3 Fbl Rpl30 Psmb5 Ube2i Psmd7 Dpf2 Psmd6 Polr1b Rnf216 Polr1a Polr1g Fbxw11 Polr1e Psmd3 Casp8ap2 Txlna Tank Gtf2i Map3k3 Actl6a Map3k2 Smarce1 Tifa Ube2d2 Polr2sl1 Flna Btrc Map3k1 Nfkbiz FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20260510%WP504%RATTUS NORVEGICUS Fatty acid biosynthesis Acsl3 Hadh Pc Decr1 Acss2 Mecr Echdc3 Echdc1 Echdc2 Echs1 Acly Acaa2 Acsl1 Scd Fasn Acacb Acsl5 Acaca Acsl6 TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20260510%WP270%RATTUS NORVEGICUS Tryptophan metabolism Tph1 Aldh3a2 Aldh9a1 Cyp2e1 Inmt Cyp2j3 Hsd17b10 Cyp2b15 Mdm2 Wars1 Cyp2j4 Ogdh Tdo2 Cyp4f1 Cyp2f2 Aadat Aldh1a1 Cyp1b1 Cyp2d2 Aldh2 Cyp7b1 Aanat Cyp1a1 Cat Afmid Gcdh Aoc1 Dhcr24 Haao Acad10 Asmt Kynu Cyp2a2 Echs1 Cyp2a1 Ube3a Acmsd Ido1 Prmt1 Hadh Ddc WNT MYOFIBROBLASTIC ACTIVATION OF HEPATIC STELLATE CELLS%WIKIPATHWAYS_20260510%WP3649%RATTUS NORVEGICUS Wnt myofibroblastic activation of hepatic stellate cells Wnt3a Pparg INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20260510%WP40%RATTUS NORVEGICUS Inflammatory response pathway Il4r Il2rb Il4 Lama5 Vtn Cd86 Il5 Cd40 Ifng Cd80 Cd40lg Il2ra Il5ra Lamc1 Lamb1 Thbs1 Lck Il2rg Il2 Tnfrsf1b Tnfrsf1a Col1a2 Col1a1 GENETIC ALTERATIONS OF LUNG CANCER%WIKIPATHWAYS_20260510%WP1968%RATTUS NORVEGICUS Genetic alterations of lung cancer Rb1 Ccne1 Ccnd1 Mapk1 Necab3 Erbb2 Mdm2 E2f1 Tp53 Crebbp Pik3cd Cdkn1a Pik3ca Bmyc Dmp1 Tgfb2 Rasl11b Smad2 Tgfb1 Egfr Smad4 Akt1 Map2k1 Raf1 BURN WOUND HEALING%WIKIPATHWAYS_20260510%WP5057%RATTUS NORVEGICUS Burn wound healing Adora2b Pdgfa Gpr176 Il1b Jun Col1a1 Tp53 Ptgis Syk Il10 Epo Casp3 Dll4 Arfgap1 Ccn2 Col4a1 Chp1 Acta1 Ankrd1 Igf1 Syp Mmp9 Il1rl1 Glb1 Cdc25b ESTROGEN METABOLISM%WIKIPATHWAYS_20260510%WP1302%RATTUS NORVEGICUS Estrogen metabolism Sult1e1 Cyp1a1 Comt Sult1a1 Arsl Gstm1 Nqo1 Cyp1b1 STEROID BIOSYNTHESIS%WIKIPATHWAYS_20260510%WP66%RATTUS NORVEGICUS Steroid biosynthesis Cyp17a1 Hsd17b7 Hsd3b5 Hsd3b2 Hsd17b3 Hsd3b1 Hsd17b4 Hsd17b1 Hsd17b2 F13b APOPTOSIS%WIKIPATHWAYS_20260510%WP1290%RATTUS NORVEGICUS Apoptosis Ripk1 Nfkbia Map2k4 Nfkbib Chuk Mapk10 Prf1 Birc5 Hells Bcl2l11 Traf1 Bcl2l2 Xiap Akt1 Bnip3l Irf4 Irf1 Irf2 Tnfrsf10b Lta Tnfrsf1b Irf6 Diablol1 Tnfrsf1a Bak1 Tnfrsf25 Faslg Igf1r Dffa Dffb Tp63 Igf2 Casp7 Bid Tradd Tp73 Casp2 Traf2 Casp9 Casp3 Pmaip1 Bax Fas Jun Bad Ikbkb Ikbkg Nfkb1 Tp53 Rela Irf3 Irf7 Irf5 Fadd Pik3r1 Map3k1 GLUCOCORTICOID EFFECT ON TARGET GENE EXPRESSION%WIKIPATHWAYS_20260510%WP1963%RATTUS NORVEGICUS Glucocorticoid effect on target gene expression Mt-co2 Tsc22d3 Nfkb1 Hspa4 Anxa1 Nfkbia Nr3c1 Fkbp4 Pla2g4a Rras INTRACELLULAR TRAFFICKING OF CFTR%WIKIPATHWAYS_20260510%WP1486%RATTUS NORVEGICUS Intracellular trafficking of CFTR Cftr Ezr Nherf1 Fblim1 Rab7a Rab11a NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20260510%WP139%RATTUS NORVEGICUS Nuclear receptors in lipid metabolism and toxicity Abcc2 Cyp26a1 Cyp2e1 Cyp7a1 Abcb11 Pparg Nr1i3 Nr1i2 Abcb1a Abcd2 Cyp27b1 Abcd3 Cyp2c11 Abcb4 Cyp4b1 Rara Rarb Cyp2b2 Cyp8b1 Vdr Nr1h3 Ppard Ppara Abcg1 Abcc3 Abca1 Cyp24a1 Abcg5 GPCRS CLASS A RHODOPSIN LIKE%WIKIPATHWAYS_20260510%WP473%RATTUS NORVEGICUS GPCRs class A rhodopsin like Gpr85 Drd1 Or7a36 Drd5 Opn4 Xcr1 Lpar5 Opn3 Olr1073 Gper1 Gpr19 Sucnr1 Or6b1 Gpr15 Or2c1 Or13c7d Or5i1 Gpr12 Adora3 Agtr1a Or2t1 Cckar Opn1sw Npbwr1 Nmur2 Prlhr Agtr2 Npy5r Ntsr2 Brs3 Gpr25 Mc2r Mas1 Gpr27 Gpr22 Gpr21 Ccr9 Mchr1 Ccr7 Htr2c Ccr6 Ccr3 Mtnr1a Npy4r Gpr37 Gpr39 Htr1d Or11a4 Htr1a Rgr Or14j1 Mc4r Or10j27 Ptafr Npffr1 Or2f2 Npffr2 Ptgdr2 Rho Hcrtr1 Or5ap2b Or2w1 Gpr37l1 Cysltr2 Cysltr1 Npy2r Ackr4 Gpr4 Cnr2 Adora2b Gpr3 P2ry6 Ackr2 Lpar6 Gpr6 Adora1 P2ry10 P2ry2 Mc3r P2ry1 Or2ag1 Lpar4 P2ry14 F2rl1 Or10a4 Gpr50 Oprk1 F2rl2 F2rl3 Ednrb Ednra Ptgdr Ptger4 Ptgfr Ptger2 Ptger3 Oxtr Ptger1 Ptgir Adora2a Cxcr1 Ntsr1 Htr7 Fshr Htr2a Ccr5 Ccr2 Adra1d Cckbr Sstr2 Htr1f C5ar2 Or3a1e Or2f1 Drd3 Drd4 Cnr1 Gpr18 Grpr P2ry13 Gpr17 Or10a5 F2r Chrm1 Chrm3 Chrm2 Chrm5 Chrm4 Hcar1 Adra2a Ghsr Adra2c Adra2b Gpr161 Npy1r Rrh Htr4 Or3a1 Htr6 Oprd1 Or2h2 Gpr65 Or2h1 Gpr68 Cxcr4 C3ar1 Gpr63 Oprl1 Bdkrb2 Adrb1 Gpr173 Adra1b Gpr174 Adra1a Adrb3 Galr2 Gpr171 Galr3 Galr1 Cmklr1 Lhcgr Sstr5 Sstr4 Sstr3 Olr226 Sstr1 Avpr1b Mc5r Oprm1 Gpr75 Htr5a Tbxa2r Or7c70 Ffar3 Fpr1 Aplnr Nmbr Fpr3 Ffar1 Bdkrb1 Fpr2 Ffar2 Ccr10 Hrh1 Or2b2 Or2j3 Hrh2 Hrh3 Or5v1b KIT RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260510%WP147%RATTUS NORVEGICUS Kit receptor signaling pathway Akt1 Shc1 Plcg1 Stat5b Tnfrsf10b Fgr Hck Btk Prkca Socs1 Jak2 Tec Fes Ptpn6 Fyn Lyn Src Rasa1 Mapk1 Prkcb Crkl Ptpn11 Pik3cg Abl1 Bad Stap1 Mitf Grb10 Socs5 Socs4 Matk Socs6 Stat5a Ptpru Map2k1 Csf2rb Cltc Stat3 Sh3kbp1 Grb2 Cblb Raf1 Vav2 Sos1 Dok1 Rps6ka1 Crk Kit Hras Spred1 Mpdz Spred2 Grb7 Grap Plce1 Sh2b2 Pik3r1 Pik3r2 ID SIGNALING PATHWAY%WIKIPATHWAYS_20260510%WP397%RATTUS NORVEGICUS ID signaling pathway Rb1 Elk1 Egf Atf3 Igf1r Ccne1 Nfkb1 Myog Ccna2 Cd40lg Flt1 Rela Myod1 Elk4 Id2 Id1 Kdr Id4 Rbl1 Id3 Hes1 Tcf7l2 Smad4 Ngf Tert Bmp6 Lck Psmd4 Pax2 Smad1 Rbl2 Bmp2 Pax8 Smad5 Igf1 Srebf1 Myf5 INTERACTIONS BETWEEN CFTR AND OTHER ION CHANNELS%WIKIPATHWAYS_20260510%WP1485%RATTUS NORVEGICUS Interactions between CFTR and other ion channels Cftr Nherf1 Scnn1b Scnn1g PROXIMAL TUBULE TRANSPORTERS%WIKIPATHWAYS_20260510%WP3881%RATTUS NORVEGICUS Proximal tubule transporters Car15 Slc26a1 Fxyd4 Slc22a5 Tctn2 Atp6v0a2 Atp6v0a4 Atp6v1g3 Atp6v0e2 Atp6v0a1 Nherf2 Slc1a1 Atp6v0c Car7 Slc4a4 Slc38a7 Slc34a1 Slc6a19 Car2 Slc7a6 Slc7a7 Atp1b1 Slc9a8 Slc13a3 Slc9a3 Slc7a8 Atp1a1 Atp6v1a Slc13a1 Slc7a9 Slc34a2 Ca4 Slc13a2 Atp6v1b2 Atp6v0d2 Atp6v0d1 Atp6v1b1 Slc16a10 Atp6v1g1 Slc22a8 Atp6v1d Ca14 Atp6v1h Nherf1 Atp6v1e1 Slc20a2 Slc22a6 RELATIONSHIP BETWEEN GLUTATHIONE AND NADPH%WIKIPATHWAYS_20260510%WP2562%RATTUS NORVEGICUS Relationship between glutathione and NADPH Gsn Cdkn1a Ftl1 G6pd Ugdh Gss Gstp1 Gsr Anpep Taldo1 Aldoa Dffa Dffb Gclm Gpi Eno1 Nnt Pgam2 Pgm2 Pgm1 Map3k5 Ptgr1 Kif1b Gapdh Pgd Tfr2 Tkt Gapdhl6 Pklr Casp3 Rpe Dpep2 Rpia Pfkl Pgk1 Alox5 Ugp2 Bax Ugt8 Fas Ltc4s Tfrc Mapk8 Gck Pgls Nqo1 Tp53 Txn1 Fth1 Abcc1 G13 SIGNALING PATHWAY%WIKIPATHWAYS_20260510%WP520%RATTUS NORVEGICUS G13 signaling pathway Iqgap2 Ppp1cb Diaph1 Tnk2 Rhpn2 Wasl Sh3rf1 Cit Limk1 Cyfip1 Rock2 Rock1 Pik3cd Mybph Mapk10 Rps6kb1 Map3k4 Iqgap1 Rac1 Cfl2 Pkn1 Pik3r2 Pip4k2a Arhgef1 Pak3 Arhgdib Cdc42 IRINOTECAN PATHWAY%WIKIPATHWAYS_20260510%WP124%RATTUS NORVEGICUS Irinotecan pathway Abcc2 Abcg2 Bche Ces1f Ces1e Abcc1 Ces1d Ces2c GLUCURONIDATION%WIKIPATHWAYS_20260510%WP1276%RATTUS NORVEGICUS Glucuronidation Ugt2b1 Ugt2b7 Pgm5 Ugt2b35 Ugt2b34 Ugt2a1 Hk1 Ugp2 Ugdh Pgm2 Pgm1 COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260510%WP547%RATTUS NORVEGICUS Complement and coagulation cascades Serpinc1 A2m Cpb2 Cd55 C1qc F13b Serpine1 F2r Kng2l1 C3ar1 Cr2 Kng2 Serping1 Cr1l Serpinf2 Mbl1 Fgb Vwf Masp1 Masp2 Tfpi C8b F3 C4a F7 F8 F9 Plaur Cfb C1qb Cfd F2 C1qa Cd59b Cfh Cfi Plg Klkb1 C2 Proc C6 C9 Serpind1 Cd46 F10 C1s C1r F12 Plat Thbd Plau Pros1 ATM SIGNALING PATHWAY%WIKIPATHWAYS_20260510%WP654%RATTUS NORVEGICUS ATM signaling pathway Rb1 Ccne1 Ccnd1 Ccnb1 Necab3 Cdk6 Brca1 Chek2 E2f1 Tp53 Cdkn1a Sfnl1 Casp9 Cdk1 Casp3 Cycs Gadd45a Pmaip1 Bax Bak1 Rprm NON HOMOLOGOUS END JOINING%WIKIPATHWAYS_20260510%WP1277%RATTUS NORVEGICUS Non homologous end joining Xrcc6 Rad50 Prkdc Xrcc4 GPCRS CLASS B SECRETIN LIKE%WIKIPATHWAYS_20260510%WP378%RATTUS NORVEGICUS GPCRs class B secretin like Calcr Adgre5 Adgrl2 Gipr Adgrl3 Gcgr Adgre1 Sctr Adgrl4 Adcyap1r1 Adgrl1 Glp2r Vipr1 Ghrhr Calcrl Glp1r Crhr2 Crhr1 WNT SIGNALING PATHWAY%WIKIPATHWAYS_20260510%WP375%RATTUS NORVEGICUS Wnt signaling pathway Camk2b Ccnd1 Apc Arrb1 Cul1 Arrb2 Akt1 Csnk2a2 Ctnnb1 Csnk2a1 Ctbp1 Ppp2ca Mark2 Wnt5a Cdh1 Ctbp2 Sox9 Prkcg Tax1bp3 Skp1 Sfrp2 Prkca Csnk2b Sfrp1 Tbp Nlk Dkk1 Magi3 Axin1 Axin2 Ror2 Crybb2 Tmem97 Csnk1d Sall1 Cdc25c Senp2 Lef1 Ruvbl1 Vangl2 Lrp6 Csnk1a1 Dab2 Lrp5 Cdk1 Tfap2a Dvl1 Dvl2 Dvl3 Wnt7a Brd7 Wnt2 Wnt4 Wnt3 Fzd2 Mapk8 Jup Fzd4 Map1b Fzd9 Mapk1 Prkcb Fzd8 Ctnnbip1 Ankrd6 Mapk3 Bcl9 Dlg1 Dlg2 Mapk8ip1 Dlg4 Tcf4 Jun Nr5a1 Hipk2 Camk2a Gsk3b Mapk9 Raf1 Wnt3a Map3k7 Rhoa Rac1 Smad4 Pax2 Camk2g Btrc Camk2d SELENIUM MICRONUTRIENT NETWORK %WIKIPATHWAYS_20260510%WP1310%RATTUS NORVEGICUS Selenium micronutrient network Mt-co2 Selenok Mthfr Tbxas1 Selenop Sod1 Fads1 Ptgis Cat Xdh Fads2 Mtr Mt-co1 Gpx1 Gpx6 Alox5 Gpx3 Gsr Kmo Tbxt Ptgds Pnpo STATIN PATHWAY%WIKIPATHWAYS_20260510%WP145%RATTUS NORVEGICUS Statin pathway Scarb1 Hmgcr Apoe Cyp7a1 Lcat Abca1 Lpl Apoc1 Mttp Soat1 NOTCH SIGNALING PATHWAY%WIKIPATHWAYS_20260510%WP517%RATTUS NORVEGICUS Notch signaling pathway Aph1a Hdac1 Ncstn Ncor2 Dtx2 Dtx3 Dtx4 Ctbp1 Dll3 Rbpjl Maml1 Ctbp2 Dtx3l Mfng Numb Hes5 Jag2 Jag1 Kat2a Rfng Notch4 Numbl Notch1 Notch2 Lfng Notch3 Psen1 Crebbp Psen2 Hes1 Dll4 Dvl1 Dvl2 Dvl3 MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20260510%WP1301%RATTUS NORVEGICUS Mitochondrial gene expression Prkar1b Tfb1m Ppp3ca Tfb2m Camk4 Mterf1 Ppargc1a Nrf1 Ppargc1b Gabpa Myef2 Esrra Gabpb2 Tfam Pprc1 Polrmt SEROTONIN AND ANXIETY%WIKIPATHWAYS_20260510%WP2132%RATTUS NORVEGICUS Serotonin and anxiety Fos Prkcb Htr2a Htr2c Nlgn1 Arc Plek Crh Grin2d Ppp3ca Adra1a Htr1a ESTROGEN SIGNALING%WIKIPATHWAYS_20260510%WP1279%RATTUS NORVEGICUS Estrogen signaling Taf12 Gtf2f2 Mapk14 Ccnd1 Gtf2b Gtf2e1 Cdk7 Polr2c Polr2a Polr2b Taf9 Polr2g Polr2h Gper1 Chuk Polr2f Polr2i Polr2j Gtf2h2 Gtf2h1 Gtf2h4 Gtf2h3 Ercc2 Ercc3 Hdac1 Esr1 Akt1 Taf7 Taf6 Taf5 Prkaca Hdac2 Tbp Brca1 Crebbp Src Mapk1 Elk1 Shc2 Jun Gngt1 Fos Gnb1 Map2k1 Mapk9 Ikbkb Grb2 Sos1 Hras Braf Mnat1 Nfkb1 Ccnh Ilk Hdac3 Hdac5 Taf13 INSULIN INDUCED PI3K AKT AND MAPK IN HEPATOCYTES%WIKIPATHWAYS_20260510%WP4229%RATTUS NORVEGICUS Insulin induced PI3K Akt and MAPK in hepatocytes Mapk1 Mapk3 Eif4ebp1 Mtor Rps6kb1 Bad Grb10 Shc1 Akt1 Irs2 Foxo1 Rptor Pfkfb2 Gys1 Grb2 Gys2 Raf1 Rheb Sos1 Foxk1 Akt1s1 Rps6ka1 Rps6 Tsc1 Gsk3a Mlst8 Pik3c3 Ins1 Eif4e Tsc2 Acly IL 3 SIGNALING PATHWAY%WIKIPATHWAYS_20260510%WP319%RATTUS NORVEGICUS IL 3 signaling pathway Mapk14 Birc5 Bcl2l11 Socs3 Akt1 Shc1 Foxo1 Slc2a1 Stat5b Ppp2ca Prkaca Tnfrsf1b Jak1 Dnm1 Hck Prkca Gsk3a Spi1 Kcnip3 Rac2 Fcer2 Mmp2 Chek1 Bcl2l1 Atf2 Rxra Gata2 Il3ra Jak2 Selp Il3 Bmx Rps6kb2 Syk Rack1 Hspb1 Gab2 Tec Fes Lck Rara Ptpn6 Vcl Bax Fyn Lyn Mapk8 Mapkapk2 Src Pxn Mapk1 Prkcb Mapk3 Crkl Pak1 Ptpn11 Rap1a Pik3cd Pik3ca Gab1 Bad Ptk2 Matk Gsk3b Stat5a Map2k1 Mapk9 Csf2rb Rapgef1 Stat3 Grb2 Raf1 Sos1 Crk Hras Nfkb1 Rac1 Ywhaq Id1 Mapk7 Pik3r1 Ywhab Pik3r2 Mmp9 Cdc42 METAPATHWAY BIOTRANSFORMATION%WIKIPATHWAYS_20260510%WP1286%RATTUS NORVEGICUS Metapathway biotransformation Gstm5 Gstm4 Gstm1 Ephx1 Akr1a1 Gsto1 Mgst3 Gstp1 Fmo1 Akr1b10 Cyp2e1 Inmt Cyp2f2 Cyp1b1 Cyp7b1 Sult1e1 Comt Sult1a1 Cyp1a1 Gpx2 Gss Gsr Chst10 Chst11 Cyp27b1 Chst12 Cyp2u1 Chst13 Cyp4f18 Chst14 Cyp4f17 Cyp26b1 Ndst1 Cyp8b1 Cyp4x1 Ndst3 Sult4a1 Cyp11b2 Sult1b1 Hs3st3b1 Gstm7 Cyp24a1 Gstcd Glyat Cyp21a1 Cyp26a1 Cyp51 Hs2st1 Cyp7a1 Cyp17a1 Tpmt Hnmt Naa50 Cyp46a1 Nat8 Nat1 Nat2 Ephx2 Nat9 Sult2b1 Sult6b2 Naa40 Nat10 Akr1b1 Ugt2b1 Mgst1 Hs3st3a1 Chst1 Sult2a1 Chst3 Sult2a6 Chst4 Chst6 Chst9 Naa30 Akr1c1 Zfp628 Gstz1 Hs3st2 Hs3st5 Hs3st6 Cyp2s1 Cyp4f39 Baat Naa20 Akr1d1 Kcnab2 Kcnab3 Cyp2r1 Fmo3 Fmo2 Fmo5 Hs6st3 Fmo4 Hs6st1 Cyp26c1 Gal3st4 Gal3st3 Akr7a3 Akr7a2 Gstk1 FRUCTOSE METABOLISM IN PROXIMAL TUBULES%WIKIPATHWAYS_20260510%WP3894%RATTUS NORVEGICUS Fructose metabolism in proximal tubules Gpi Akr1b1 Slc5a9 Psme3 Slc5a10 Tpi1 Sord Aldob G6pc1 Hk1 Khk Pfkl Tkfc Naglt1 Fbp1 Slc2a5 Pfkp Aldoa POLYOL PATHWAY%WIKIPATHWAYS_20260510%WP1303%RATTUS NORVEGICUS Polyol pathway Akr1b1 Sord Aldob Khk HYPERTROPHY MODEL%WIKIPATHWAYS_20260510%WP442%RATTUS NORVEGICUS Hypertrophy model Il1a Dusp14l1 Ifrd1 Il1r1 Ccn1 Nr4a3 Myog Eif4ebp1 Ifng Hbegf Eif4e Ankrd1 Atf3 Jund Wdr1 Zeb1 IL 5 SIGNALING PATHWAY%WIKIPATHWAYS_20260510%WP44%RATTUS NORVEGICUS IL 5 signaling pathway Mapk14 Nfkbia Rap1gap Itgam Pim1 Sox4 Sdcbp Alox5ap Hcls1 Itgb2 Cdkn1b Unc119 Akt1 Shc1 Ctnnb1 Stat5b Jak1 Hck Btk Gsk3a Socs1 Atf2 Jak2 Foxo3 Syk Ptpn6 Alox5 Bax Prkcd Lyn Mapk1 Prkcb Elk1 Mapk3 Shc2 Crkl Ptpn11 Pik3cg Jun Ptk2b Gsk3b Stat5a Mapk9 Rapgef1 Stat3 Grb2 Raf1 Pla2g4a Rps6ka1 Hras Nfkb1 Il5 Sh2b2 Rac1 Il5ra Pik3r1 Pik3r2 PHASE I BIOTRANSFORMATIONS NON P450%WIKIPATHWAYS_20260510%WP1291%RATTUS NORVEGICUS Phase I biotransformations non P450 Ces5a Pon1 Pon2 Lipa Ces2j Esd Pon3 HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20260510%WP1296%RATTUS NORVEGICUS Homologous recombination Pold1 Pold2 Rad51 Rad50 Brca2 Rad52 Pold4 Pold3 Fsbp Nbn WNT SIGNALING PATHWAY AND PLURIPOTENCY%WIKIPATHWAYS_20260510%WP1288%RATTUS NORVEGICUS Wnt signaling pathway and pluripotency Ccnd1 Apc Fosl1 Mapk10 Ppp2r3a Ppp2r2c Ppp2r2b Ctnnb1 Ppp2cb Ctbp1 Ppp2ca Wnt5a Ctbp2 Ptpa Pafah1b1 Sox2 Wnt5b Prkca Wnt9b Wnt16 Nlk Fbxw2 Wnt11 Axin1 Tcf7 Axin2 Nkd2 Wnt6 Tmem97 Tcf7l1 Cd44 Pou5f1 Fzd3 Ppp2r2a Crebbp Ccnd2 Lef1 Nanog Wnt2b Ppp2r1a Ppm1j Lrp6 Lrp5 Dvl1 Dvl2 Prkcq Dvl3 Wnt7a Wnt2 Ppard Prkci Wnt4 Prkcd Wnt3 Prkce Fzd2 Fzd4 Fzd9 Prkcb Fzd8 Jun Prkcz Gsk3b Mapk9 Wnt3a Map3k7 Rhoa Tp53 Plau VEGF RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20260510%WP1965%RATTUS NORVEGICUS VEGF receptor signal transduction Pxn Mapk1 Rac1 Bad Sh2d2a Pgf Casp9 Hspbp1 Vegfc Vegfb Shc1 Akt1 Pik3r3 Nos3 Plcg1 Grb2 Prkci Raf1 Mapkapk2 Src Prkca MONOAMINE GPCRS%WIKIPATHWAYS_20260510%WP276%RATTUS NORVEGICUS Monoamine GPCRs Chrm2 Htr2a Drd1 Chrm5 Chrm4 Drd5 Adra2a Adra2c Adra1d Adra2b Htr4 Htr6 Htr1f Adrb1 Adra1b Adra1a Drd3 Adrb3 Drd4 Htr2c Htr1d Htr1a Htr5a Htr5b Hrh1 Hrh2 Chrm1 Htr7 Chrm3 EBV LMP1 SIGNALING%WIKIPATHWAYS_20260510%WP1278%RATTUS NORVEGICUS EBV LMP1 signaling Mapk1 Nfkb2 Nfkb1 Rela Chuk Tradd Ifnb1 Map3k14 Pdlim7 Ikbkb Traf6 Mapk8 Ccl5 Map3k7 OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20260510%WP1283%RATTUS NORVEGICUS Oxidative phosphorylation Ndufa8 Atp5pf Ndufb10 Atp5po Ndufs3 Ndufs2 Ndufs5 Ndufs4 Ndufs6 Mt-co3 Ndufs8 Mt-nd5 Adck2 Mt-nd4 Ndufb2 Mt-atp6 Mt-nd6 Atp5mc1 Mt-nd1 Ndufb6 Mt-nd3 Mt-nd4l Ndufb5 Mt-nd2 Ndufb8 Ndufb7 Atp5mc3 Atp5mf Atp5me Ndufv1 Ndufv3 Atp5f1a Ndufa10l1 Ndufab1 Ndufc1 Ndufc2 Ndufa2 Ndufa5 Gzmb Ndufa4 Atp5pb Gzmc Ndufa9 INSULIN SIGNALING%WIKIPATHWAYS_20260510%WP439%RATTUS NORVEGICUS Insulin signaling Pdpk1 Akt2 Akt1 Shc1 Irs2 Slc2a1 Lipe Prkca Map3k9 Map3k5 Rps6ka5 Map3k14 Tsc2 Prkcq Prkci Prkcd Mapk8 Mapk1 Prkcb Elk1 Mapk3 Shc2 Eif4ebp1 Map2k7 Ptpn11 Jun Mtor Rps6kb1 Prkcz Gab1 Cblc Fos Grb10 Pten Map4k1 Gsk3b Map2k2 Map2k1 Mapk9 Prkch Rapgef1 Ikbkb Grb2 Cblb Raf1 Sos1 Map3k8 Rps6ka1 Crk Map3k7 Hras Cyth3 Grb14 Trib3 Map3k6 Stxbp1 Sh2b2 Stxbp2 Stxbp3 Stxbp4 Prkaa1 Prkaa2 Gyg1 Kif5b Shc3 Insr Flot2 Flot1 Map4k5 Map4k4 Map4k3 Rab4a Egr1 Xbp1 Kif3a Tbc1d4 Map4k2 Ehd1 Map2k6 Ehd2 Snap25 Snap23 Reg1a Arf1 Rhoj Mapk13 Slc2a4 Mapk14 Ptprf Cap1 Rrad Inpp4a Map2k4 Ppp1r3a Vamp2 Rps6ka3 Rps6ka4 Rps6ka6 Mapk10 Mink1 Sgk3 Sgk2 Myo1c Enpp1 Map3k4 Ptpn1 Stx4 Arhgap33 Map3k10 Map3k11 Map3k13 Foxo1 Mapk11 Rptor Gys1 Gys2 Rheb Rps6ka2 Tsc1 Igf1r Sgk1 Gsk3a Rac2 Socs1 Mapk4 Inppl1 Foxo3 Rps6kb2 Eif4e Pfkl Mapk12 Pik3cg Pik3cd Pik3c2a Pik3c2g Pik3c3 Rac1 Sos2 Pik3r1 Pik3r2 Map3k3 Map3k2 Map3k1 ADIPOGENESIS%WIKIPATHWAYS_20260510%WP155%RATTUS NORVEGICUS Adipogenesis Celf1 Lpl Socs3 Irs2 Stat5b Lipe Wnt5b Mef2d Dvl1 Fas Serpine1 Scd Stat5a Ncor2 Stat3 Pparg Tnf Trib3 Necab3 Ptgis Rbl1 Id3 Ppargc1a Tgfb1 Rbl2 Bmp2 Gadd45a Igf1 Srebf1 Il6 Rb1 Slc2a4 E2f1 Cdkn1a Foxo1 Nampt Nrip1 Ahr Lifr Prlr Foxc2 Twist1 Ebf1 Mif Retn Il6st Lmna Mbnl1 Frzb Cebpb Ins2 Cntfr Gata3 Gata4 Ncoa1 Socs1 Rxrg Rxra Gh1 Gata2 Hif1a Gtf3a Ndn Cisd1 Pck1 Pck2 Egr2 Lif Bmp4 Bmp3 Wwtr1 Hnf1a Bmp1 Rara Nr3c1 Hmga1 Cyp26b1 Plin1 Adipoq Epas1 Nr1h3 Sfrp4 Nr2f1 Ppard Ppara Klf15 Ncor1 Ucp1 Gadd45b Pnpla3 Cebpd Lpin3 Cyp26a1 Ncoa2 Zmpste24 Asip Osm Lpin1 Plin2 Dlk1 Bscl2 Mixl1 Mef2a Mef2b Klf6 Mef2c Klf5 Lep Spock1 Gdf10 Agpat2 Agt Cfd IL 1 SIGNALING PATHWAY%WIKIPATHWAYS_20260510%WP355%RATTUS NORVEGICUS IL 1 signaling pathway Il1a Mapk1 Tollip Il1r1 Mapk3 Nfkbia Nfkbib Il1b Ptpn11 Chuk Prkcz Il1rap Peli1 Irak4 Irak3 Irak2 Akt1 Capn1 Sirpa Map2k1 Il1r2 Plcg1 Capns1 Tab1 Traf6 Il1rn Map3k7 Nfkb1 Rela Elp1 Map3k14 Sqstm1 Mapk8 CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260510%WP632%RATTUS NORVEGICUS Cholesterol metabolism Lss Scarb1 Hmgcs1 Mvd Msmo1 Dhcr7 Lpl Apoc1 Hmgcr Apoe Fdps Srebf1 Idi1 Mvk Rusc1 Apoc2 Soat1 Fdft1 NUCLEAR RECEPTORS%WIKIPATHWAYS_20260510%WP217%RATTUS NORVEGICUS Nuclear receptors Nr5a1 Esr1 Pparg Nr2c2 Nr2e1 Hnf4a Esrrb Nr2f6 Rxrg Thrb Rxra Nr1d2 Thra Nr1i3 Nr2f2 Nr1i2 Rorc Nr1h2 Esr2 Rxrb Ror1 Nr5a2 Nr4a2 Esrra Rara Nr3c1 Rarb Vdr Nr1h3 Nr2f1 Ppard Ppara GPCRS CLASS C METABOTROPIC GLUTAMATE PHEROMONE%WIKIPATHWAYS_20260510%WP42%RATTUS NORVEGICUS GPCRs class C metabotropic glutamate pheromone Grm8 Gprc5b Gprc5a Casr Gprc5d Gprc5c Grm3 Grm2 Grm5 Grm4 Grm7 Grm1 Gabbr1 Grm6 Gabbr2 PENTOSE PHOSPHATE PATHWAY%WIKIPATHWAYS_20260510%WP282%RATTUS NORVEGICUS Pentose phosphate pathway Tkt Rpe Rpia G6pd Kif1b Taldo1 Pgls Pgd AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20260510%WP1300%RATTUS NORVEGICUS Aflatoxin B1 metabolism Akr7a3 Akr7a2 Gstm1 Ephx1 OSTEOBLAST SIGNALING%WIKIPATHWAYS_20260510%WP227%RATTUS NORVEGICUS Osteoblast signaling Slc34a1 Bglap Pth Pdgfrb Pdgfra Tnfsf11 Fgf23 Col1a1 SELENIUM METABOLISM SELENOPROTEINS%WIKIPATHWAYS_20260510%WP1293%RATTUS NORVEGICUS Selenium metabolism selenoproteins Selenok Selenbp1 Eefsec Nfe2l2 Crem Sp3 Selenof Sars2 Selenoi Sars1 Fabp1 Jun Selenoo Selenop Selenos Dio1 Txnrd2 Selenot Dio2 Dio3 Fos Selenov Sephs1 Trnau1ap Gpx2 Gpx3 Nfkb1 Rela Rpl30 Gpx6 Msrb1 Selenow SPINAL CORD INJURY%WIKIPATHWAYS_20260510%WP2433%RATTUS NORVEGICUS Spinal cord injury Rb1 Il1a Ccnd1 Il1r1 Il1b E2f1 E2f5 Btg2 Bdnf Fkbp1a Ptprz1 Slit1 Slit2 Aqp4 Slit3 Pdyn Sox9 Rhoc Rgma Nox4 Vcan Prkca Sema6a Lilrb2 Tnfsf13b Zfp36 Gap43 Arg1 Ccng1 Prpg2 Omg Plxna2 Epha4 Mag Rtn4r Selp Tacr1 Ngfr Pla2g2a Chst11 Ntn1 Klk8 Rtn4 Gfap Cdk1 Bcan Casp3 Tnfsf13 C5 Gdnf Ccl2 Pla2g5 Mbp Il2 Cd47 Cxcl1 Cxcl2 Grin1 Pla2g6 Fcgr2a Nos2 Mapk1 Ptpra Ncan Acan Mapk3 Xylt1 Vim Rock2 Ppp3ca Gja1 Fos Il4 Necab3 Ifng Tp53 Tgfb1 Nos1 Anxa1 Tlr4 Egr1 Gadd45a Col4a1 Cxcl10 Il6 Mmp9 RENIN ANGIOTENSIN SYSTEM%WIKIPATHWAYS_20260510%WP376%RATTUS NORVEGICUS Renin angiotensin system Mapk13 Map2k4 Mapk10 Agtr1a Shc1 Agtr2 Prkaca Anpep Mas1 Itpr3 Itpr2 Itpr1 Atf2 Plcb1 Jak2 Prkcq Mapk8 Mapk1 Elk1 Mapk3 Ctsg Pak1 Cpa3 Map2k7 Mme Ace2 Enpep Jun Ctsa Nln Pik3ca Cma1 Lnpep Ptk2b Fos Ptk2 Ace Ren Mapk9 Ikbkb Stat3 Agt Grb2 Raf1 Ikbkg Rac1 Rela Ptgir Pak6 Pak3 Pak2 Pak5 Pak4 Map3k1 SULINDAC METABOLIC PATHWAY%WIKIPATHWAYS_20260510%WP2541%RATTUS NORVEGICUS Sulindac metabolic pathway Cyp1a1 Msrb2 Msra METHYLATION%WIKIPATHWAYS_20260510%WP1282%RATTUS NORVEGICUS Methylation Mat1a Comt Pnmt Mat2a Inmt Hnmt MAPK SIGNALING PATHWAY%WIKIPATHWAYS_20260510%WP358%RATTUS NORVEGICUS MAPK signaling pathway Il1a Il1r1 Egf Mos Akt3 Akt2 Arrb2 Akt1 Bdnf Prkaca Prkcg Tnfrsf1a Prkca Atf2 Map3k5 Tgfb2 Hspb1 Traf2 Mapkapk5 Casp3 Tgfbr1 Daxx Map3k14 Prkacb Fas Prkcd Mapk8 Rasa1 Mapk1 Elk1 Mapk3 Crkl Pak1 Map2k7 Mapk8ip1 Rap1a Jun Ppp3ca Ppp3cc Fos Cacng8 Map4k1 Cacna1g Cacna1h Cacna1e Map2k1 Mapk9 Cacng7 Cacna1f Ikbkb Cacna1c Grb2 Traf6 Cacna1d Raf1 Cacna1a Ikbkg Sos1 Cacna1b Pla2g4a Cacng1 Map3k8 Crk Map3k7 Cacng4 Hras Cacng5 Cacng3 Cacna1s Map3k20 Nfkb2 Lamtor3 Nfkb1 Map3k6 Rasgrp3 Rasgrp4 Rasgrp1 Flnc Tp53 Rela Rasgrp2 Flnb Elk4 Stmn1 Stk4 Tgfb3 Nf1 Ppp3cb Rasgrf2 Tgfb1 Ppp5c Pla2g4b Map4k4 Pla2g4e Ngf Map4k3 Pla2g4d Nfatc1 Nfatc3 Cacna2d1 Cacna2d3 Gadd45a Cacna2d4 Map4k2 Dusp16 Ptpn7 Map2k6 Ptpn5 Dusp3 Ntf4 Dusp2 Cdc25b Hspa1l Dusp4 Mapk13 Ntf3 Mapk14 Dusp10 Dusp9 Dusp8 Cacnb4 Map2k4 Cacnb1 Cacnb2 Il1b Tab2 Rps6ka3 Arrb1 Taok2 Rps6ka4 Taok1 Chuk Taok3 Mapk10 Ntrk2 Ntrk1 Rapgef2 Mapk8ip3 Map3k4 Map3k11 Mapt Map3k13 Faslg Nlk Fgf2 Fgf1 Fgf4 Tmem97 Fgf3 Fgf6 Fgf5 Fgf8 Fgf7 Fgf9 Egfr Nras Mapkapk2 Mknk1 Pdgfrb Pdgfa Rras2 Mef2c Fgfr3 Fgfr4 Fgfr1 Fgfr2 Il1r2 Cd14 Gng12 Fgf16 Fgf17 Fgf14 Fgf18 Fgf19 Braf Fgf12 Fgf13 Fgf10 Fgf11 Rac1 Fgf20 Rras Sos2 Gna12 Map3k2 Pak2 Flna Jund Map3k1 Cdc42 CATECHOLAMINE SYNTHESIS%WIKIPATHWAYS_20260510%WP513%RATTUS NORVEGICUS Catecholamine synthesis Pah Pnmt Dbh Ddc Th GLYCOGEN METABOLISM%WIKIPATHWAYS_20260510%WP160%RATTUS NORVEGICUS Glycogen metabolism Calm2 Ppp2r3a Ppp2r2c Gbe1 Ppp2r2b Phkb Phka1 Gsk3b Phka2 Pygb Ppp2cb Phkg1 Ppp2ca Phkg2 Gys1 Agl Gys2 Pygm Ptpa Gsk3a Ppp2r5b Ppp2r5a Ppp2r2a Pgm1 Gyg1 Ppp2r1a Ugp2 PEPTIDE GPCRS%WIKIPATHWAYS_20260510%WP131%RATTUS NORVEGICUS Peptide GPCRs Ccr5 Ccr2 Cckbr Sstr2 Agtr1a Cckar Agtr2 Npy5r Ntsr2 Brs3 Cxcr6 Tacr3 Mc2r Tacr2 Tshr Tac4 Grpr Ccr7 Ccr6 Ccr3 Npy4r Tacr1 Mc4r Npy2r Ghsr Mc3r Npy1r Oprk1 Oprd1 Cxcr4 C3ar1 Oprl1 Bdkrb2 Ednrb Ednra Galr2 Galr3 Galr1 Lhcgr Sstr5 Oxtr Sstr4 Sstr3 Sstr1 Avpr1b Mc5r Oprm1 Fpr1 Nmbr Fpr3 Bdkrb1 Fpr2 Ccr10 Cxcr1 Gnrhr Ntsr1 Fshr AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20260510%WP1287%RATTUS NORVEGICUS Amino acid conjugation of benzoic acid Acss2 Glyat TRANSLATION FACTORS%WIKIPATHWAYS_20260510%WP149%RATTUS NORVEGICUS Translation factors Gspt2 Cluh Eif4ebp1 Eef1a2 Eef1d Eif3j Pycr3 Eif2s3 Eif2ak1 Eef1g Eif4ebp2 Eif2ak2 Eif3f Eif4g1 Eif4g3 Eif3a Eif1a Eif5b Eif5a Eif2b3 Eif2b2 Eif4e Eif2b5 Eif2ak3 Eif2b4 Kcnq2 Eif2s2 Eef2k Eif2b1 Eif4h Eif3b Paip1 Eif1 Eif1ax Eif6 Eif4a2 Eif4a1 Etf1 STRIATED MUSCLE CONTRACTION%WIKIPATHWAYS_20260510%WP316%RATTUS NORVEGICUS Striated muscle contraction Tnnt3 Tnnt2 Tnnt1 Tnnc2 Vim Tnnc1 Tmod1 Tpm4 Actg1 Tpm3 Tpm2 Neb Tnni3 Tnni2 Tnni1 Myh3 Actn2 Actn3 Mybpc3 Myh8 Actn4 Myl9 Myh6 Myl2 Actc1 Acta1 Acta2 SMALL LIGAND GPCRS%WIKIPATHWAYS_20260510%WP161%RATTUS NORVEGICUS Small ligand GPCRs Cnr1 Ptger4 Cnr2 Ptgfr Ptger2 Ptger3 Ptger1 Mtnr1a Ptgir Ptafr Lpar1 S1pr1 S1pr3 Ptgdr BIOSYNTHESIS OF ALDOSTERONE AND CORTISOL%WIKIPATHWAYS_20260510%WP508%RATTUS NORVEGICUS Biosynthesis of aldosterone and cortisol Cyp21a1 Cyp17a1 Hsd3b2 Cyp11b2 HYPOTHETICAL NETWORK FOR DRUG ADDICTION%WIKIPATHWAYS_20260510%WP1281%RATTUS NORVEGICUS Hypothetical network for drug addiction Camk2b Mapk1 Drd1 Mapk3 Map2k1 Grin2a Nisch Krit1 Prkaca Terf2ip Gria2 Gria1 Ppa1 Drd4 Grin2c Grin2b Adcy1 Adcy8 Camk4 Acta1 Grm5 Grin2d Prkce Grm1 Grin1 P53 SIGNAL PATHWAY%WIKIPATHWAYS_20260510%WP656%RATTUS NORVEGICUS p53 signal pathway Ccnb3 Gadd45g Ccne1 Gtse1 Bbc3 Parp1 Mdm2 Tp53 Igfbp3 Bid Casp9 Cdk1 Casp3 Perp Siah1 Pmaip1 Bax Igf1 Fas Rprm TYPE II INTERFERON SIGNALING IFNG %WIKIPATHWAYS_20260510%WP1289%RATTUS NORVEGICUS Type II interferon signaling IFNG Nos2 Il1b Ptpn11 Socs3 Irf4 Irf1 Irf2 Jak1 Spi1 Ifngr2 Psmb9 Ifng Oas1a Socs1 Ifngr1 Eif2ak2 Gbp1 Tap1 Ciita Jak2 Cybb Irf8 Isg15 Hist1h2ao Irf9 Ifit2 Ifnb1 Cxcl10 Prkcd Cxcl9 Reg1a FOCAL ADHESION%WIKIPATHWAYS_20260510%WP188%RATTUS NORVEGICUS Focal adhesion Vasp Srms Txk Pdgfc Chad Itga8 Egf Itga6 Itga9 Itgam Itga3 Cav1 Itga4 Rock1 Pdgfb Itga10 Cav3 Cav2 Pdpk1 Itgb2 Akt3 Tesk2 Col4a2 Tnk1 Akt2 Ptk6 Col4a6 Ibsp Akt1 Shc1 Pelo Itgax Itgav Itgae Itgal Itgad Itgb8 Itgb6 Itga2b Itgb5 Actn1 Col11a1 Col11a2 Lamb3 Vegfd Col6a2 Lamc3 Styk1 Zyx Pip5k1c Ccnd2 Pgf Vegfc Vegfb Itgb3 Spp1 Mapk8 Src Pxn Mapk1 Elk1 Dock1 Erbb2 Pak1 Rap1a Jun Rap1b Pik3ca Selenop Hgf Bad Pten Ptk2 Gsk3b Itgb1 Map2k2 Mylk2 Map2k1 Mapk9 Rapgef1 Grb2 Raf1 Sos1 Met Crk Col1a2 Hras Col1a1 Lama5 Vtn Flt1 Lamc1 Lamb1 Thbs1 Kdr Shc3 Col4a1 Igf1 Map2k6 Ilk Ccnd1 Mapk14 Map2k3 Fgr Hck Igf1r Rac2 Mapk4 Egfr Actb Vcl Mapk12 Fyn Diaph1 Tnk2 Pdgfrb Pdgfra Pdgfa Pik3cg Actg1 Rock2 Pik3cd Capn1 Mylk Vwf Braf Rac1 Pik3r5 Mapk7 Tnc Comp Pik3r1 Ppp1r12a Pik3r2 Tnn Tnr Col5a1 Arhgap5 Reln Bcar1 Lama2 Pak6 Lama3 Lama4 Pak3 Tln1 Pak2 Thbs2 Pak5 Thbs4 Pak4 Blk Cdc42 MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20260510%WP278%RATTUS NORVEGICUS Matrix metalloproteinases Tnf Mmp2 Mmp11 Cep295nl Mmp23 Mmp24 Mmp14 Mmp15 Mmp16 Mmp28 Mmp17 Timp3 Timp2 Timp4 Bsg Tcf20 Mmp21 Mmp9 APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20260510%WP487%RATTUS NORVEGICUS Apoptosis modulation by HSP70 Ripk1 Nfkb1 Mapk10 Casp7 Bid Casp2 Casp9 Fadd Casp3 Cycs Casp6 Aifm1 Hspa1b Fas Tnfrsf1a Faslg Map3k1 INTEGRIN MEDIATED CELL ADHESION%WIKIPATHWAYS_20260510%WP74%RATTUS NORVEGICUS Integrin mediated cell adhesion Vasp Itga8 Itga6 Map2k3 Itgam Itga9 Itga3 Cav1 Itga4 Capn3 Rock1 Mapk10 Itga10 Cav3 Pdpk1 Itgb2 Cav2 Akt3 Akt2 Akt1 Shc1 Itgax Itgav Itgae Itgal Itgad Itgb8 Itgb6 Itga2b Itgb5 Rac2 Zyx Mapk4 Itgb3 Vcl Rho Mapk12 Arhgef7 Vav3 Itgb4 Fyn Itga2 Capn9 Src Git2 Capn5 Pxn Capn7 Mapk1 Capn6 Capn2 Dock1 Pak1 Itga1 Rap1a Rock2 Rap1b Selenop Ptk2 Itgb1 Capn1 Map2k2 Mylk2 Map2k1 Rapgef1 Capns1 Grb2 Raf1 Vav2 Sos1 Crk Hras Braf Rac1 Shc3 Mapk7 Pik3r2 Bcar1 Pak6 Map2k6 Pak3 Ilk Tln1 Pak2 Pak4 Cdc42 EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP1284%RATTUS NORVEGICUS EPO receptor signaling Mapk1 Ptprc Mapk3 Pdk1 Socs1 Pik3cg Jak2 Epo Shc1 Akt1 Irs2 Map2k2 Stat5a Ptpru Map2k1 Stat5b Stat3 Grb2 Raf1 Sos1 Src Rasa1 CFTR ACTIVITY IN THE PLASMA MEMBRANE%WIKIPATHWAYS_20260510%WP1488%RATTUS NORVEGICUS CFTR activity in the plasma membrane Plcz1 Cftr Pdzk1 Nherf1 Plcb1 Nherf2 Prkaa2 Rack1 Ezr Ppp2ca Prkaca Plcb2 Prkcg Plcb3 Snap23 VEGFR 3 SIGNALING%WIKIPATHWAYS_20260510%WP1964%RATTUS NORVEGICUS VEGFR 3 signaling Mapk1 Vegfd Mapk3 Itpkc Flt4 Pik3cg Bad Casp9 Vegfc Shc1 Akt1 Nos3 Plcg1 Grb2 HEXOSES METABOLISM IN PROXIMAL TUBULES%WIKIPATHWAYS_20260510%WP3916%RATTUS NORVEGICUS Hexoses metabolism in proximal tubules Pdha1 Pc Pdk4 Pdk3 Dld Pdk2 Tpi1 Ldhb Aldoa Gpi Eno1 Pgam2 Pck1 Gapdh Pklr Pfkl Pgk1 Acly Pdk1 Pdhx Eno3 Eno2 Mpc1 Mpc2 Slc2a2 Pgam1 Akr1b1 Ldha Aldoc Slc5a1 Slc5a2 Got1 Got2 Pdp1 Hk1 Pdp2 Slc5a9 Psme3 Slc5a10 Sord Aldob G6pc1 Khk Tkfc Fbp1 Mdh1 Slc2a5 Mdh2 Pdhb Pfkp BRAIN DERIVED NEUROTROPHIC FACTOR%WIKIPATHWAYS_20260510%WP2148%RATTUS NORVEGICUS Brain derived neurotrophic factor Plg Mapk1 Bdnf Map2k1 Raf1 Ntrk2 Serpine1 Plat Ngfr TRANSCRIPTIONAL ACTIVATION BY NFE2L2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20260510%WP1280%RATTUS NORVEGICUS Transcriptional activation by Nfe2l2 in response to phytochemicals Cebpb Nfe2l2 Gclm Nqo1 Aimp2 Maf Hmox1 Ephb2 Mapk8 Prkca RETINOL METABOLISM%WIKIPATHWAYS_20260510%WP1297%RATTUS NORVEGICUS Retinol metabolism Scarb1 Cyp26a1 Sult1a1 Cyp2e1 Sult2b1 Adh4 Aldh1a1 Lpl Adh1 Adh5 Dhrs3 Cd36l1 Rdh12 Aldh1a3 Rdh10 Bco1 Npc1l1 Rpe65 Rbp7 Rbp4 Retsat Crabp2 Cd36 Rxrg Lrat Rxra Rlbp1 Rxrb Rara Rarb Cyp26b1 Abcg5 TNF ALPHA AND MUCUS PRODUCTION IN LUNG EPYTHELIUM%WIKIPATHWAYS_20260510%WP1487%RATTUS NORVEGICUS TNF alpha and mucus production in lung epythelium Tnf Mapk1 Ripk2 Nfkb1 Nfkbia Rela Muc2 Chuk Tradd Tgfa Traf2 Egfr Shc1 Tlr4 Map2k1 Ikbkb Grb2 Raf1 Ikbkg Il6 Sos1 Tnfrsf1a Rps6ka2 CARDIOVASCULAR SIGNALING%WIKIPATHWAYS_20260510%WP590%RATTUS NORVEGICUS Cardiovascular signaling Capn6 Wasf1 Erbb2 Pdgfra Egf Rras2 Selenop Col4a2 Akt1 Vav2 Vwf Col11a1 Col1a1 Vegfd Stmn1 Wnt2b Casp2 Hspb1 Cfl1 Pgf Tnc Casp3 Col5a1 Col4a1 Casp6 Arhgef7 Hspa1b Wnt2 Map2k6 Mapk8 Thbs2