TUMOR SUPPRESSOR ACTIVITY OF SMARCB1%WIKIPATHWAYS_20260510%WP4204%HOMO SAPIENS Tumor suppressor activity of SMARCB1 DPF3 SMARCE1 SUZ12 SMARCC1 SMARCC2 H3F3B ACTL6B EED CDKN2A PTCH1 ACTL6A ARID1A ARID1B SMARCA4 CDK6 SMO CDK4 EZH2 RB1 SMARCD1 SMARCD2 SMARCD3 GLI3 GLI4 RBBP4 DPF1 DPF2 MAPK AND NFKB SIGNALING INHIBITED BY YERSINIA YOPJ%WIKIPATHWAYS_20260510%WP3849%HOMO SAPIENS MAPK and NFkB signaling inhibited by Yersinia YopJ IKBKB NFKBIA MAP3K1 CHUK RRAS TRAF6 MAPK1 IKBKG RAF1 MAP3K14 NFKB1 MAP2K6 CALCIUM REGULATION IN CARDIAC CELLS%WIKIPATHWAYS_20260510%WP536%HOMO SAPIENS Calcium regulation in cardiac cells CHRM2 CHRM3 HEL2 CHRM1 CHRM4 CHRM5 SLC8A1 RGS4 RGS5 RGS2 GJA1 GJA3 RGS1 GJA5 GJA4 GJA9 GJA8 RGS6 RGS7 PRKCH PRKCB PRKCE PRKCA ATP1B3 ATP1B2 ATP1B1 CACNB1 CACNB3 ADCY9 PRKAR1B STIM2 PRKAR1A ORAI1 PRKCQ PRKD1 GNAZ CACNA1B CACNA1A ITPR2 ADRB1 CACNA1C ADRB2 PRKCZ GJC1 GRK5 GRK4 SFN CACNA1S GNG12 GNG11 GNG13 GNAO1 PKIB GJB2 GJB1 GJB4 GJB3 PKIA GJB6 GNB2 FXYD2 GNB1 GNAS GNB4 GNB3 GNB5 PKIG CALM1 RYR1 RYR2 ATP2A2 ADRA1D ARRB2 ADRA1B ADRA1A RYR3 GNGT1 YWHAQ ANXA6 HEL-S-1 YWHAG YWHAZ GJD2 PLCB3 ADRB3 CASQ2 CASQ1 RGS18 RGS17 CAMK2D RGS14 RGS16 CAMK2A ATP1A4 GNAI3 ADCY3 ADCY1 ADCY8 HEL-S-99n GNAI1 ADCY6 GNG3 PLN GNG2 GNG5 GNG4 GNG7 GNA11 RGS20 GNG8 CAMK2G KCNJ3 KCNJ5 KCNB1 ATP2B3 CXNO ATP2B2 ATP2B1 FKBP1A CAMK4 CXNA RGS10 CAMK1 RGS11 SARS COV 2 MITOCHONDRIAL CHRONIC OXIDATIVE STRESS AND ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260510%WP5183%HOMO SAPIENS SARS CoV 2 mitochondrial chronic oxidative stress and endothelial dysfunction MITA TERF2 TNF ACE2 MAVS IL6 TRAF3 RPS6KA1 NDUFAF2 NLRP3 TERF2IP REN NDUFAF1 TRAF6 TOMM70 NLRX1 ACAD9 NFKB1 IL18 SIRT6 ECSIT ETHYLMALONIC ENCEPHALOPATHY%WIKIPATHWAYS_20260510%WP5030%HOMO SAPIENS Ethylmalonic encephalopathy ETHE1 SUOX CORTICOTROPIN RELEASING HORMONE SIGNALING%WIKIPATHWAYS_20260510%WP2355%HOMO SAPIENS Corticotropin releasing hormone signaling CREB1 CYP21A2 GNAZ CRH TLR4 IVL PRKAA2 RELA CACNA1H CRHR1 ACACA CRHR2 MAPK9 MAPK8 CYP11A1 PLCG2 PLCG1 MAPK3 TFAP2A GNAO1 TGFB1 JUND JUP HSD3B2 HSD3B1 BRAF MAPK14 IL2 GNB2 FOSL2 POMC GNB1 FOSL1 GNAS ARHA STAR GNB3 SP1 GNB5 KRT14 BCL2 CTNNB1 FOSB TCF4 ARRB2 CAMK2A GNAI1 GNA11 NFKBIA MAPK1 RAF1 NFKB1 IL18 GJA1 GSK3B CXCL8 ECE1 CASP9 PRKCB CRHBP CASP12 PRKCA TRIM28 CASP3 JUNB MAP3K5 SULT2A1 PRKCI MAP2K1 PARP1 KRT1 FOS ERN1 PRKCQ HEMOGLOBIN SWITCHING EMBRYONIC FETAL AND ADULT%WIKIPATHWAYS_20260510%WP5605%HOMO SAPIENS Hemoglobin switching embryonic fetal and adult HBZ tal-1 HBG2 LDB1 HBG1 LMO2 HBE1 HBB HBA2 HBD GATA1 ESTROGEN SIGNALING%WIKIPATHWAYS_20260510%WP712%HOMO SAPIENS Estrogen signaling CREB1 BCL2 GNGT1 MAPK9 JUN PIK3CA IKBKB GPER CHUK BRAF MAPK14 MAPK1 IKBKG MAP2K1 GNB1 NFKB1 GNAS FOS SP1 GENES RELATED TO PRIMARY CILIUM DEVELOPMENT BASED ON CRISPR %WIKIPATHWAYS_20260510%WP4536%HOMO SAPIENS Genes related to primary cilium development based on CRISPR TMEM231 IFT20 TTC8 TMEM17 SASS6 MKS1 IFT27 CEP162 B9D1 CIBAR1 DNCL1 CLUAP1 CEP44 IFT25 DYNC2I2 TTC23 C2CD3 TRAF3IP1 CEP19 IFT172 CBY1 EFCAB7 TXNDC15 IFT52 TCTN3 TCTN2 TMEM107 TCTN1 CDK20 TRAPPC11 BBS9 BBS7 KIFAP3 CEP97 IFT57 CC2D2A IFT56 BBS5 BBS4 DYNC2H1 OFD1 DYNLT1 IFT140 CEP295 ARMC9 IFT80 RPGRIP1L WDR35 LZTFL1 BBS10 IFT43 EVC BBS12 IFT81 TMEM216 CCDC41 WDPCP CEP20 IFT46 TEDC1 CEP104 IFT70B TEDC2 ARL6 ARL3 FBF1 DYNLT2B KATNB1 TUBD1 DYNC2LI1 IFT74 ARL13B KIF3B KIF3A TMEM67 RAB23 INPP5E KIAA0753 CEP192 CEP76 PIBF1 EVC2 BBS2 BBS1 SCLT1 RABL2B CPLANE1 TUBE1 FUZ CPLANE2 MIB1 HALLMARK OF CANCER SUSTAINING PROLIFERATIVE SIGNALING%WIKIPATHWAYS_20260510%WP5475%HOMO SAPIENS Hallmark of cancer sustaining proliferative signaling RELA CDKN1A FLT1 FLT3 MAPK3 FLT4 PTEN PIK3CD NR1C2 JUP IGF1R RPTOR DEPTOR BRAF CCND1 SALL4 MYC AKT3 KDR MLST8 HRAS IL6R PDGFRA MAP2K2 KSR1 CTNNB1 TSC2 TSC1 AXIN2 TTI1 GAREM2 PYGO1 AKT1S1 KIT RARA ULK2 SOS1 SOS2 MET EPHA2 JUN PIK3CA CSF1R SHC1 SRC LEF1 LRP5 RETN EGFR FOXO1 LRP6 WNT1 RUNX1T1 NTRK1 NGFR NTRK2 CSNK1A1 ZBTB16 INSR STAT3 PML MTOR BCL9 APC RHEB REL MDM2 KRAS GRB2 TCF3 FGFR4 NFKBIE FGFR3 FGFR2 FGFR1 IKBKB NFKBIA CHUK MAPK1 IKBKG RAF1 NFKB1 IL6 GSK3B MAP2K1 FOS SICKLE CELL DISEASE%WIKIPATHWAYS_20260510%WP5604%HOMO SAPIENS Sickle cell disease IL1B TLR4 HBB IL18 HBA2 MELANOMA%WIKIPATHWAYS_20260510%WP4685%HOMO SAPIENS Melanoma CDKN1A MAPK3 PTEN PIK3CD BRAF CCND1 AKT3 KDR ARHA HRAS MAP2K2 CALM1 KIT SOS1 SOS2 PIK3CA RB1 CDKN2A MDM2 KRAS GRB2 CDK6 CDK4 CALML6 ARAF HEL114 CALML3 CALML4 GRM3 MAPK1 PREX2 RAC1 RAF1 POLK EXOC7 RHOB DDB2 PDE5A SHC2 PIK3R3 PIK3R2 PIK3R1 NRAS PAK1 ERBB4 E2F2 E2F3 BAK1 GADD45B BAD GADD45A PTPN11 GADD45G NF1 BAX MAP2K1 MIRNAS INVOLVED IN DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260510%WP1545%HOMO SAPIENS miRNAs involved in DNA damage response CREB1 H2AX RAD52 CCND3 CDKN1B CCNE1 ATM CCND1 MYC CDKN1A CDK6 CELL CYCLE%WIKIPATHWAYS_20260510%WP179%HOMO SAPIENS Cell cycle CDC27 CHEK1 EP300 SKP2 SKP1 ANAPC7 CDC25B RBX1 CCNE2 ANAPC5 MAD1L1 ANAPC1 ANAPC2 ANAPC13 PRKDC PKMYT1 ANAPC10 ANAPC11 CCNB3 TGFB1 CCNB2 CCNB1 ORC6 ORC3 RAD21 ORC2 SMAD2 SMAD4 PLK1 CDC6 CDC2 STAG1 CDK7 STAG2 CDK2 ATR CDKN1C MCM7 ORC1L SMC1A SMC1B RBL2 CCNA2 RBL1 DBF4 TFDP1 ESPL1 TFDP2 MCM3 MCM5 MCM6 MCM2 HDAC2 PCNA HDAC1 TTK RB1 FZR1 CDC45 E2F4 E2F5 CDKN2D CDKN2B CDKN2C MAD2L2 WEE1 WEE2 CDKN2A CDK6 CDK4 HEL2 SFN CDKN1A CCND1 MYC YWHAQ HEL-S-1 YWHAG YWHAZ MDM2 E2F2 E2F3 GADD45B GADD45A GADD45G GSK3B CCND3 CDKN1B CCNE1 ATM CCNH SMC3 CDC14B CDC20 CDC23 CCND2 PTTG1 PTTG2 CHEK2 RETINOBLASTOMA GENE IN CANCER%WIKIPATHWAYS_20260510%WP2446%HOMO SAPIENS Retinoblastoma gene in cancer CHEK1 SKP2 CDC25B CCNE2 CDKN1A PRKDC CCNB2 CCNB1 CCND1 MYC CDC2 CDK2 MCM7 ORC1L SMC1A CCNA2 TFDP1 TFDP2 MCM3 MCM6 PCNA HDAC1 TTK RB1 CDC45 RBBP4 WEE1 TOP2A SUV39H1 FAF1 HMGB2 HMGB1 SMC2 SIN3A POLE RFC3 MDM2 RFC4 PRMT2 SAP30 MSH6 RBP1 CDK6 PRIM1 TYMS CDK4 POLD3 NPAT HLTF RBBP7 H2AZ1 BARD1 PLK4 CDT1 RRM1 RAF1 RRM2 RPA1 FANCG MAPK13 DHFR POLA1 POLE2 RPA3 CCDC6 ZNF655 E2F2 E2F3 CCND3 CDKN1B CCNE1 SMC3 PROLINE AND HYDROXYPROLINE PATHWAYS%WIKIPATHWAYS_20260510%WP5026%HOMO SAPIENS Proline and hydroxyproline pathways PRODH OCTADECANOID FORMATION FROM LINOLEIC ACID%WIKIPATHWAYS_20260510%WP5324%HOMO SAPIENS Octadecanoid formation from linoleic acid GPX4 CYP4A11 ALOX15 EPHX3 ALOX12B CYP3A4 PTGS2 CYP2C19 PTGS1 CYP2C9 CYP2C8 CYP1A2 ALOXE3 MIRNA BIOGENESIS%WIKIPATHWAYS_20260510%WP2338%HOMO SAPIENS miRNA biogenesis XPO5 DGCR8 DROSHA DICER1 TARBP2 RAN CYCLIN DEPENDENT KINASE 4 6 INHIBITORS IN BREAST CANCER%WIKIPATHWAYS_20260510%WP5497%HOMO SAPIENS Cyclin dependent kinase 4 6 inhibitors in breast cancer MTOR KRAS CDKN1A CDK6 MAPK3 CDK4 PIK3CD IGF1R RPTOR CCND1 MAPK1 RAF1 AKT3 HRAS PIK3R3 CDK2 PIK3R2 PIK3R1 NRAS PIK3CA CDKN1B CCNE1 EGFR IRS1 PIK3R4 PIK3C2G PIK3C2A INS PIK3C2B PIK3R5 ERBB2 MICRORNA NETWORK ASSOCIATED WITH CHRONIC LYMPHOCYTIC LEUKEMIA%WIKIPATHWAYS_20260510%WP4399%HOMO SAPIENS MicroRNA network associated with chronic lymphocytic leukemia ZAP70 BCL2 MCL1 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES APOPTOSIS%WIKIPATHWAYS_20260510%WP4864%HOMO SAPIENS Host pathogen interaction of human coronaviruses apoptosis BCL2 MCL1 APAF1 TNF MAPK12 BBC3 MAPK11 CASP8 BCL2L11 TNFSF6 FADD BCL2L1 BAD BAX CASP9 CASP3 MAPK14 MAPK13 IL5 SIGNALING%WIKIPATHWAYS_20260510%WP127%HOMO SAPIENS IL5 signaling STAT3 KRAS GSK3A GRB2 IL5RA CSF2RB SPRED1 FOXO3A MAPK3 JAK1 LYN STAT5B SYK STAT1 RPS6 RPS6KB1 RPS6KB2 MAPK1 BTK IL2 RAF1 MAP2K2 PIK3R2 PIK3R1 RPS6KA1 PTPN11 SOS1 GSK3B JUN SHC1 MAP2K1 PPAR ALPHA PATHWAY%WIKIPATHWAYS_20260510%WP2878%HOMO SAPIENS PPAR alpha pathway KLK15 CYP7A1 APOA5 CYP8B1 FABP1 RXRA CYP4A11 CPT2 EHHADH ACADM UGT1A9 PLTP CDK4 CCND1 SLC27A1 CPT1A MYC APOA2 APOC3 NR1H3 CDC2 NR1C1 DBI ERBB SIGNALING%WIKIPATHWAYS_20260510%WP673%HOMO SAPIENS ErbB signaling BCL2L11 MAPK9 MAPK8 CDKN1A PLCG2 MAPK3 STAT5B PIK3CD RPS6KB1 BRAF RPS6KB2 CCND1 MYC AKT3 HRAS MAP2K2 AREG CRKL NCK2 SOS1 NCK1 SOS2 MAP2K4 PDPK1 JUN NRG1 PIK3CA NRG2 SHC1 EREG SRC BTC NRG3 NRG4 CRK CAMK2D EGFR HBEGF FOXO1 SHC4 SHC3 CAMK2A TGFA CBL ERBB3 EIF4EBP1 PAK6 ABL2 PAK4 EGF MAPK10 MTOR MDM2 KRAS GRB2 CAMK2G ARAF MAPK1 RAF1 SHC2 PIK3R3 PIK3R2 PIK3R1 NRAS PAK1 ERBB4 BAD GSK3B PRKCB CDKN1B PRKCA MAP2K1 ERBB2 HAIR FOLLICLE DEVELOPMENT ORGANOGENESIS STAGE 2 OF 3%WIKIPATHWAYS_20260510%WP2839%HOMO SAPIENS Hair follicle development organogenesis stage 2 of 3 ITGB1 LAMA5 FOXI3 PDGFA SHH NCAM1 PTCH1 TP63 FZD1 TNLG7C INHBA RUNX2 GTPBP4 SMO BMP4 FGFR2 EDAR SNAI1 CCND1 GJB6 MYC NFKB1 PDGFRA CTNNB1 LEF1 LRP5 CCND2 FATTY ACID OMEGA OXIDATION%WIKIPATHWAYS_20260510%WP206%HOMO SAPIENS Fatty acid omega oxidation CYP4A11 CYP3A4 CYP1A2 ADH1C HEL-S-117 ADH1A ADH7 ADH6 CYP2A6 ALDH2 HEL-S-53e CYP1A1 CYP2E1 HEL-S-4 HEAD AND NECK SQUAMOUS CELL CARCINOMA%WIKIPATHWAYS_20260510%WP4674%HOMO SAPIENS Head and neck squamous cell carcinoma PRKAA2 CASP8 RELA FADD CDKN1A PTEN IGF1R RPS6 RPTOR RPS6KB2 CCND1 SMAD4 AKT3 MLST8 HRAS CTNNB1 TSC2 TSC1 PDPK1 PIK3CA RB1 EGFR EIF4EBP1 MTOR RHEB CDKN2A REL TP63 KRAS CDK6 FGFR3 CDK4 FGFR1 FKBP1A NFKB1 MAML1 KEAP1 STK11 SESN1 SESN2 PIK3R2 TGFBR2 PIK3R1 DDIT4 NRAS NUMB TRAF3 IRF6 AJUBA BIRC2 NOTCH2 PRKAA1 NOTCH1 MAPKAP1 TERT RICTOR CSMD3 EIF4E VEGFA NFKB2 FAT1 LTBR NFE2L2 PIK3R5 ERBB2 BETA GLOBIN GENE EXPRESSION REGULATION%WIKIPATHWAYS_20260510%WP5606%HOMO SAPIENS Beta globin gene expression regulation ZBTB7A tal-1 HBG2 LDB1 HBG1 LMO2 HBE1 HBB HBD GATA1 HDAC2 HDAC1 KDM1A BCL11A CHD3 NR2C2 GATAD2B KLF1 MYB MTA2 PPARGC1A ZFPM1 GNAQ PATHWAYS IN PORT WINE STAIN%WIKIPATHWAYS_20260510%WP5437%HOMO SAPIENS GNAQ pathways in port wine stain YAP1 MAP2K2 MAP2K3 TRIO MTOR AMOT MAP2K5 MAP2K4 MAPK3 PIK3CA MAPK1 RAC1 RAF1 MAP2K1 NFKB1 ARHA MAP2K6 IL9 SIGNALING%WIKIPATHWAYS_20260510%WP22%HOMO SAPIENS IL9 signaling MAP2K2 STAT3 PIK3R2 PIK3R1 IL2RG CDK9 IL9 JAK3 IL9R GRB2 MAPK3 JAK1 STAT5B STAT1 MAPK1 MAP2K1 GLYCINE METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260510%WP5028%HOMO SAPIENS Glycine metabolism including IMDs LIPT2 LIPT1 GLDC SHMT1 HEL-S-302 AMT HSCB LIAS NFU1 GCSH BOLA3 DLD ISCU NIPBL ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260510%WP5119%HOMO SAPIENS NIPBL role in DNA damage Cornelia de Lange syndrome H2AX ATR ATM RNF168 MDC1 NIPBL CBX3 RNF8 REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20260510%WP51%HOMO SAPIENS Regulation of actin cytoskeleton MAPK3 BRAF CYFIP2 ARHA NCKAP1 FGF2 ARHGAP35 MYLK ACTG1 FGF7 FGF8 FGF9 CFL2 PIP4K2A PIP4K2B HEL70 ACTN1 F2R MYL1 MYL3 PFN1 EZR PXN IQGAP1 PIK3CA HEL-S-15 FGF20 PIP5K1A PIP5K1C CD14 FGF23 MYH10 FGF22 FGF21 RDX RASSF7 ARPC5 SSH2 SSH3 FGF16 FGF14 FGF18 FGF13 FGF12 FGF10 BRK1 STM7 FGF8A PS1TP5BP1 PIP5KL1 TMSB4X BDKRB2 BDKRB1 RAC3 APC2 ITGA1 RRAS2 FGF7B F2 VAV1 FGF7A RRAS ARHGEF4 ARHGEF1 ARHGEF7 MAPK1 DOCK1 RAF1 ROCK1 ROCK2 WAS FGF6B CHRM2 FGD1 CHRM3 GNA13 CDC42 CHRM1 CSK CHRM4 WASF1 CHRM5 MAPK6 WASF2 MAPK4 LIMK1 FGF5C BAIAP2 MOS ABI2 PIK3R4 PIK3C2G PIK3C2A PIK3C2B PIK3R5 GNG12 PIK3CD PDGFRA MAP2K2 SOS1 SOS2 CRK EGFR PAK6 PAK4 EGF APC PDGFA KRAS FGFR4 FGFR3 FGFR2 FGFR1 HEL114 RAC1 PIK3R3 PIK3R2 PIK3R1 NRAS PAK1 MAP2K1 SHANK3 PATHWAY INVOLVED IN PHELAN MCDERMID SYNDROME%WIKIPATHWAYS_20260510%WP5566%HOMO SAPIENS SHANK3 pathway involved in Phelan McDermid syndrome ITGB1 PS1TP5BP1 ARHGEF7 HRAS CDC42 PAK1 BAIAP2 GRIA2 SPAAR CTNND2 ARHGAP44 SHARPIN RAP1A SYNGAP1 DLGAP1 MAP3K7 SPTAN1 LZTS3 HOMER1 GRIN2B GRIN1 DLG4 CAMK2A ADGRL1 SHANK3 HCN1 FBXL10 ENHANCEMENT OF MAP ERK SIGNALING IN DIFFUSE LARGE B CELL LYMPHOMA%WIKIPATHWAYS_20260510%WP4553%HOMO SAPIENS FBXL10 enhancement of MAP ERK signaling in diffuse large B cell lymphoma H2AB1 MACROH2A2 SUZ12 MACROH2A1 RNF2 H2AJ H3F3B H3C15 BCL6 EED PCGF1 BCOR MAPK3 H2AX EZH2 H2AZ1 MAPK1 H2AZ2 H3C8 H2AB3 PERTURBED THYROID HORMONE HOMEOSTASIS LEADING TO DEVELOPMENTAL NEUROTOXICITY%WIKIPATHWAYS_20260510%WP5517%HOMO SAPIENS Perturbed thyroid hormone homeostasis leading to developmental neurotoxicity SLCO1C1 SLC7A5 SLCO3A1 SLCO4A1 SLCO1A2 SLC16A10 SLC16A2 TH17 CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260510%WP5130%HOMO SAPIENS Th17 cell differentiation pathway ZAP70 MAPK8 PLCG1 IF2B1 JAK1 IL23R RORC TGFB1 CD3G RORA STAT1 IL27 AHR CD3E CD3D MAPK14 IL-21 SMAD2 IL2 IL27RA PPP3CA IFNGR1 TYK2 FOXP3 IL6R TGFBR1 RUNX1 IFNG IL23A LCK IRF4 CRY1 RXRA GATA3 HIF1A SOCS3 HLA-DMA NFIL3 RARA TBX21 IL21R NFATC1 NR1D1 IL4 JUN PER1 IL2RA IL17F LAT IL17A STAT3 MTOR IKBKB IL1B NFKBIA MAPK1 NFKB1 IL6 FOS PRKCQ LINOLEIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260510%WP5137%HOMO SAPIENS Linoleic acid oxylipin metabolism ALOX5 EPHX2 ALOX15 MFAP5 EFFECT ON PERMEABILITY AND MOTILITY OF ENDOTHELIAL CELLS VIA CYTOSKELETON REARRANGEMENT%WIKIPATHWAYS_20260510%WP4560%HOMO SAPIENS MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement CREB1 MYLK ACTN1 PLCG1 JUN PXN MAPK3 HEL114 ITGB3 LPP MAPK1 MFAP5 TJP1 MYL2 ITGAV PRKCQ T CELL RECEPTOR AND CO STIMULATORY SIGNALING%WIKIPATHWAYS_20260510%WP2583%HOMO SAPIENS T cell receptor and co stimulatory signaling CD8B1 ZAP70 NFATC2 CALM1 CD8A LCK CTLA4 FYN PTPN6 PDCD1 GSK3A GSK3B PLCG1 PTEN NFKBIA PRKCA IL2 PPP3CA NFKB1 ITK DYRK2 CSNK1A1 DYRK1A HEPATITIS C AND HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260510%WP3646%HOMO SAPIENS Hepatitis C and hepatocellular carcinoma STAT3 BRCA1 CXCR1 TNFSF6 FRZB NOS2 BCL2L1 MYOF GRB2 MAPK8 HNF1A VAV2 CDKN1A COL4A2 BIRC5 MAPK3 JAK1 HEL-117 CD44 TGFB1 BIRC3 CCND1 MAPK14 MYC RAC1 SMAD4 RRM2 NFKB1 IL6R TGFBR1 IL6 HIF1A E2F2 PTGS2 PTPN11 SOS1 CXCL8 JUN VEGFA CASP9 LEF1 CASP3 EFFECT OF OMEGA 3 PUFA ON HUNTINGTON 39 S DISEASE PATHWAYS%WIKIPATHWAYS_20260510%WP5470%HOMO SAPIENS Effect of omega 3 PUFA on Huntington 39 s disease pathways CREB1 GABRA3 REST RAB3GAP1 PRKAA2 MAPK9 MAPK8 MAPK3 SP1 BCL2 PIK3CA HDAC2 HDAC1 SIN3A IKBKB MAPK1 RAF1 NFKB1 PIK3R4 PIK3C2G PIK3C2A PIK3C2B PIK3R5 CASP8 BCL2L11 BCL2L1 PTEN PIK3CD RPTOR RPS6KB1 DEPTOR AKT3 MLST8 HRAS MAP2K2 TSC2 TSC1 AKT1S1 MAP2K4 EGFR EIF4EBP1 NTRK2 EGF MAPK10 MTOR RHEB IL1B CYP46A1 RPS6KA5 KIF5A PRKAB2 GABRG3 PRKAB1 GABRG2 GABRG1 ABCG4 ABCG1 NEUROD1 MBP PI3 APOE PIK3R3 ABCA1 PIK3R2 BDNF PIK3R1 MAP3K10 DHCR7 IL6 GABRB3 GABRB2 GABRB1 PRKAG1 PRKAG2 PRKAG3 PRKAA1 AHI-1 BAD OPA1 HMGCS1 HEL-S-29 RICTOR SREBF2 HAP1 EIF4E BAX C1QA HTT HMGCR GABRE SLC12A2 CASP3 GABRQ GABRA2 GABRP SLC12A5 GABRA6 MAP2K1 GABRA5 BNIP3 NR1H2 PPARGC1A GABRA4 CYP51A1 SEROTONIN HTR1 GROUP AND FOS PATHWAY%WIKIPATHWAYS_20260510%WP722%HOMO SAPIENS Serotonin HTR1 group and FOS pathway CREB1 GNAI1 MAP2K3 STAT3 RASGRF1 HTR2A HTR1E HTR1F HTR1D HTR1B MAPKAPK3 MAPKAPK2 5HT1A MAPK3 GNAO1 RPS6KA5 MAP3K1 BRAF MAPK1 MAPK14 MAP2K6 ARHA MAP2K2 RAP1A PDPK1 PIK3CA MAP2K1 GNAI3 FOS ARYL HYDROCARBON RECEPTOR PATHWAY%WIKIPATHWAYS_20260510%WP2873%HOMO SAPIENS Aryl hydrocarbon receptor pathway EP300 SLC7A5 MYOF MGST1 CYP1B1 IL12B UGT1A4 HES1 IL12A UGT1A3 TGFB1 IL1B UGT1A7 JUND CAP2 IGFBP1 AHR NCOA1 NQO1 SERPINB2 UGT1A1 IL2 PTGES3 POLK AIP CYP1A1 ALDH3A1 CDC37 AHRR CES3 IL17B IFNG TNF UGT1A9 JUN CYP1A2 BAX SRC CDKN1B NFE2L2 EGFR JUNB DOPAMINE METABOLISM%WIKIPATHWAYS_20260510%WP2436%HOMO SAPIENS Dopamine metabolism PPP2CA DDC TH MAOA PRKACG HEL-S-44 NQO1 TYR BMP2 WNT4 FOXO1 PATHWAY IN PRIMARY ENDOMETRIAL STROMAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260510%WP3876%HOMO SAPIENS BMP2 WNT4 FOXO1 pathway in primary endometrial stromal cell differentiation CTNNB1 BCL2L11 SMAD1 SMAD9 DKK1 DCN SFRP1 BMP2 SST DKFZp781O1323 LEFTY2 WNT4 FOXO1 CANCER IMMUNOTHERAPY BY PD 1 BLOCKADE%WIKIPATHWAYS_20260510%WP4585%HOMO SAPIENS Cancer immunotherapy by PD 1 blockade CD8B1 ZAP70 NFATC2 IFNG STAT3 CD8A LCK PDCD1 NFATC1 PTPN11 JUN NFAT5 NFATC3 CD3G PDCD1LG2 HLA-A NFATC4 CD3E BATF CD3D HLA-DRB1 NFKB1 PEROXISOMAL BETA OXIDATION OF TETRACOSANOYL COA%WIKIPATHWAYS_20260510%WP1941%HOMO SAPIENS Peroxisomal beta oxidation of tetracosanoyl CoA ACOX1 HSD17B4 GASTRIN SIGNALING%WIKIPATHWAYS_20260510%WP4659%HOMO SAPIENS Gastrin signaling CREB1 RELA MAPK9 MAPK8 PLCG1 MAPK3 SERPINB2 MAPK14 IL2 ARHA SP1 CTNNB1 TCF4 BMP2 PXN JUN PIK3CA ATF2 CLDN1 KAT5 MEF2C MEF2B SLC9A3 PRKD2 ARHGEF28 EGR1 YES1 MAP3K11 ELAVL1 MMP7 ANXA2 CDKN2A RHOD CCKBR GAS TFF2 PPARG HDC HDAC7 MEF2D KLF4 IKBKB LAMTOR3 NFKBIA CHUK MAPK1 RAF1 ROCK1 NFKB1 CDC42 PTGS2 PRKCH PRKCE PRKCA IRS1 PRKCQ PRKD1 BCL2L1 CDKN1A FOXO3A RPS6 RPS6KB1 CCND1 MYC HRAS ARRB2 KIT SOS1 SHC1 SRC CRK EGFR FOXO1 TJP1 EIF4EBP1 STAT3 ITGB1 FYN MTOR KRAS GRB2 BIRC5 CD44 BIRC3 RAC1 RHOB PIK3R3 PIK3R2 PIK3R1 PAK1 BIRC2 BAD PTPN11 GSK3B CXCL8 VEGFA CDKN1B CASP3 MAP2K1 FOS COMPLEMENT SYSTEM IN NEURONAL DEVELOPMENT AND PLASTICITY%WIKIPATHWAYS_20260510%WP5090%HOMO SAPIENS Complement system in neuronal development and plasticity DIABLO C1R APAF1 C5AR2 CFI C5AR1 HTRA2 CASP8 PARD6G ATP10A CFP PRKCZ TNFSF6 C4B_2 C2 VTN PARD6B PARD6A C6 C7 C9 CD59 DEDD TGFB1 CD55 MARK1 ATP8B3 ATP8B2 ATP8B1 HEL-S-62p MERTK AXL FAS CYCS PALS1 C1QC IFNG ITGB3 ITGAV FCN1 FCN2 PATJ FCN3 ITGAM PROS1 C4BPA C4BPB CLU C8A CX3CL1 C4A MBP C8G CASP10 ITGAX C3AR1 DLGAP5 MBL2 CAP1 CR2 CR1 ATP11C SCRIB BAK1 ATP11A PLSCR1 PLSCR3 PARD3 PLSCR4 TYRO3 SERPING1 BAX MASP2 C1QA CASP9 MASP1 CD46 MFGE8 LLGL2 CASP3 CFD CRB2 COLEC12 C1QB PRKCI CX3CR1 COLEC11 CRB1 COLEC10 C1S CFH CELL DIFFERENTIATION INDEX%WIKIPATHWAYS_20260510%WP2029%HOMO SAPIENS Cell differentiation index LEFTY1 LEFTY2 TLX3 TLX2 STAT3 TLX1 HDAC5 PRE IMPLANTATION EMBRYO%WIKIPATHWAYS_20260510%WP3527%HOMO SAPIENS Pre implantation embryo MACROH2A2 FOSB NANOGNB IRF4 AQP3 NR3C2 GATA3 FOXQ1 SOX2 ZFP36 DNMT3L KHSRP SIX3 SOX8 MYBL1 TEAD4 BATF3 FOXD1 SOX11 POU5F1 ZAR1 ARGFX DPPA3 DDIT3 ZFP42 DLX2 PADI6 E2F5 ATP1A1 GATA2 BARX2 ZFP36L2 LEUTX NKX2-1 MTA3 ESRRA EGR1 TFAP2B TCF7L1 CDX2 ELAVL1 IRX5 HMGA1 TPRX1 HNRNPAB PBX1 TBX3 DPRX SMARCA4 ZSCAN4 MXD1 KLF4 MOS RENIN ANGIOTENSIN ALDOSTERONE SYSTEM RAAS %WIKIPATHWAYS_20260510%WP4756%HOMO SAPIENS Renin angiotensin aldosterone system RAAS CREB1 CYP21A2 ITPR2 CAMK2G CYP11A1 ATF1 ATF6B CREB3L3 CREB3L4 CALML6 CREB3L2 CTSG CAMK1D HSD3B2 CAMK4 CALML3 CMA1 HSD3B1 CALML4 CREB3 CYP11B2 CAMK1 AGTR1 AGTR2 PLCB2 CAMK1G CREB5 STAR ATF4 CALM1 REN CAMK2D CAMK2A ATF2 SELENIUM METABOLISM AND SELENOPROTEINS%WIKIPATHWAYS_20260510%WP28%HOMO SAPIENS Selenium metabolism and selenoproteins SELS RELA NFKB1 RPL30 SP1 CREM HEL-S-134P SELENOF SELENOK SELENOI FABP1 SELENOH GPX4 SEPHS1 SEPHS2 PSTK EEFSEC GPX2 GPX1 POU2F1 TXNRD3 GPX3 TXNRD2 JUN GPX6 DIO1 TRNAU1AP SELENOO SEPSECS SELENON NFE2L2 SARS1 SELENOM SARS2 CTH SP3 SELENOP SELENOW SELENOV FOS SELENOT MSRB1 2Q13 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP5222%HOMO SAPIENS 2q13 copy number variation syndrome CHTM1 IL1RN CSF2 CSF1 ZC3H8 CXCL13 ZNRD1 BCL2L11 IL36A IL36B PSD4 ARL14 ANAPC1 CKAP2L IL1R1 IL1A PLCG2 POLR1A POLR1C POLR1D POLR1F POLR1G ARF6 STAT1 FBLN7 TMEM87B SLC20A1 RGPD8 TULP1 MERTK IL2 TTL IL1RL2 SOCS1 NT5DC4 POLR2F IL36RN POLR2H POLR2K IL23A POLR2L IL37 IL36G IL1F10 GATA3 SOCS3 GRB2 IL1B MAPK1 RAC1 IL6 FAMILIAL HYPERLIPIDEMIA TYPE 3%WIKIPATHWAYS_20260510%WP5110%HOMO SAPIENS Familial hyperlipidemia type 3 APOE SCARB1 LIPC LPL APOA4 VLDLR PLTP APOA2 LDLR OMEGA 9 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260510%WP4724%HOMO SAPIENS Omega 9 fatty acid synthesis ELOVL1 ELOVL5 ACSL1 ELOVL2 SCD5 ELOVL3 FACL4 ELOVL6 ACSL3 FADS2 SCD FASN FADS1 TCA CYCLE AND DEFICIENCY OF PYRUVATE DEHYDROGENASE COMPLEX PDHC %WIKIPATHWAYS_20260510%WP2453%HOMO SAPIENS TCA cycle and deficiency of pyruvate dehydrogenase complex PDHc PC OGDH SUCLG2 DLAT PCK1 HEL60 DLD FH PDHA1 HEL-S-32 SDHA HEL-S-26 CS ACLY SEROTONIN AND ANXIETY RELATED EVENTS%WIKIPATHWAYS_20260510%WP3944%HOMO SAPIENS Serotonin and anxiety related events PRKCB CRH HTR2A NLGN1 ARC PLEK CRHR1 PLCD4 PPP3CA 5HT1A FOS PYRIMIDINE METABOLISM AND RELATED DISEASES%WIKIPATHWAYS_20260510%WP4225%HOMO SAPIENS Pyrimidine metabolism and related diseases GLS2 AGXT2 DPYS CAD ABAT TYMP TYMS DHODH NT5C3A RRM2B DPYD HEL74 UMPS OTC RRM1 RRM2 AEROBIC GLYCOLYSIS AUGMENTED%WIKIPATHWAYS_20260510%WP4628%HOMO SAPIENS Aerobic glycolysis augmented HEL-S-49 HEL-S-87p HEL-S-30 PGAM2 HEL-S-133P GPT ENO1 HEL-S-68p PFKM HEL-S-162eP INSULIN SIGNALING IN ADIPOCYTES NORMAL CONDITION %WIKIPATHWAYS_20260510%WP3634%HOMO SAPIENS Insulin signaling in adipocytes normal condition TBC1D4 INSR SLC2A4 MTOR RPS6 RPS6KB1 IRS1 NAD METABOLISM IN ONCOGENE INDUCED SENESCENCE AND MITOCHONDRIAL DYSFUNCTION ASSOCIATED SENESCENCE%WIKIPATHWAYS_20260510%WP5046%HOMO SAPIENS NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence SLC2A4 MDH2 GOT2 SIRT5 IL6 NMNAT2 ELAVL1 RELA HMGA1 SIRT1 SIRT2 SIRT3 PRKAA1 NAMPT CCL27 IL1B HEL-S-32 PARP1 COPPER HOMEOSTASIS%WIKIPATHWAYS_20260510%WP3286%HOMO SAPIENS Copper homeostasis MT1A SCO1 MTF1 MT1F MT1G ADAM9 APC MT1B XAF1 STEAP1 MDM2 STEAP2 MT1E FOXO3A PTEN CCND1 SP1 HEL-S-44 APP STEAP3 STEAP4 GSK3B COX17 MT2A JUN ATP7B PIK3CA COX11 ATP7A PRNP SLC31A2 CASP3 SLC31A1 SLC11A2 FOXO1 ADAM10 COMMD1 MT4 MT3 ATOX1 BACE1 ADAM17 CCS INSULIN SIGNALING IN ADIPOCYTES DIABETIC CONDITION %WIKIPATHWAYS_20260510%WP3635%HOMO SAPIENS Insulin signaling in adipocytes diabetic condition TBC1D4 INSR SLC2A4 MTOR RPS6 RPS6KB1 IRS1 UTERINE NATURAL KILLER CELLS AND PROGESTERONE ESTROGEN AND CHORIONIC GONADOTROPIN%WIKIPATHWAYS_20260510%WP5569%HOMO SAPIENS Uterine natural killer cells and progesterone estrogen and chorionic gonadotropin MCL1 MAPK11 IL2RG JAK3 NR3C1 MRC1 MADCAM1 IL10 IL15RA JAK1 ITGA4 MAPK3 IL15 GAB3 STAT5B HLA-G NCR1 NCR2 NR3A2 NCR3 PGR CXCR4 KIR2DL4 CCL8 CCL7 CCL5 CXCR3 CCL4 CCL3 IFNG CCL2 BCL2 ANGPT2 VCAM1 ANGPT1 IL3 CXCL11 CXCL12 SELL IL2RB CD69 MAP2K4 IL4 GATA2 CX3CL1 TNF IL6 CXCL8 VEGFA PIBF1 WNT SIGNALING NETPATH%WIKIPATHWAYS_20260510%WP363%HOMO SAPIENS Wnt signaling NetPath NFATC2 MTOR BCL9 APC STM7 GSK3A MAPK9 MAPK8 TCF3 PPARG CDK6 CCND1 MAPK1 RAC1 ARHA CTNNB1 TSC2 TSC1 TCF4 ARRB2 CTBP1 NLK FRAT1 SOX1 GSK3B DVL1 DVL2 DVL3 TCF7L2 PRKCB MAP3K7 GCKR LEF1 RYK PRKCA LRP5 AXIN1 CSNK1D CSNK1E ROR1 LRP6 ROR2 PI4K2A CSNK1G1 CSNK1A1 VITAMIN B12 DISORDERS%WIKIPATHWAYS_20260510%WP4271%HOMO SAPIENS Vitamin B12 disorders TCN2 CBLIF TCN1 MTR MMACHC MMADHC CD320 CUBN AMN MTRR MMAA VISUAL CYCLE%WIKIPATHWAYS_20260510%WP5534%HOMO SAPIENS Visual cycle RDH8 ABCA4 RLBP1 RPE65 OPN1SW OPN1MW RDH12 OPN1LW RBP1 RBP3 RDH11 RDH10 RHO RDH5 LRAT PTDINS 4 5 P2 IN CYTOKINESIS PATHWAY%WIKIPATHWAYS_20260510%WP5199%HOMO SAPIENS PtdIns 4 5 P2 in cytokinesis pathway SEPTIN2 RAB35 KIF23 OCRL HEL70 MYL2 RDX ARHA EZR BLADDER CANCER%WIKIPATHWAYS_20260510%WP2828%HOMO SAPIENS Bladder cancer EGF CDKN2A MDM2 KRAS CDKN1A TYMP FGFR3 CDK4 ARAF RPS6KA5 BRAF CCND1 MAPK1 THBS1 RASSF1 MYC RAF1 MMP2 DAPK2 MMP9 HRAS UPK3A MAP2K2 PIK3R2 PIK3R1 NRAS CXCL8 VEGFA SRC RB1 EGFR HBEGF MAP2K1 ERBB2 MITOCHONDRIAL COMPLEX IV ASSEMBLY%WIKIPATHWAYS_20260510%WP4922%HOMO SAPIENS Mitochondrial complex IV assembly COX19 COX7B COX16 COX18 TACO1 COX4I1 COX7A2 HIGD1A COX6A1 COX7C COX5A COX3 COX2 COX14 COA6 CSRP2BP COX17 COX10 COX8A COA3 COX11 SURF1 PET100 FAM36A CMC1 COX6B1 TMEM177 PNKD COXFA4 SMIM20 PGK1 PKM2 KHKC KHKA ACTING AS PROTEIN KINASES%WIKIPATHWAYS_20260510%WP5433%HOMO SAPIENS PGK1 PKM2 KHKC KHKA acting as protein kinases H2AX STAT3 H3F3B HEL-S-30 AKT1S1 MYL2 SNAP23 KHK HEL-S-68p HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20260510%WP186%HOMO SAPIENS Homologous recombination POLD2 POLD3 MRE11A RAD52 NBN BRCA2 RAD54B ATM RPA1 POLD4 RAD50 RAD51 BIOMARKERS FOR PYRIMIDINE METABOLISM DISORDERS%WIKIPATHWAYS_20260510%WP4584%HOMO SAPIENS Biomarkers for pyrimidine metabolism disorders TYMS DHODH NT5C3A RRM2B DPYD HEL74 UMPS RRM1 RRM2 DPYS HEL-S-29 TYMP PRIMARY OVARIAN INSUFFICIENCY%WIKIPATHWAYS_20260510%WP5461%HOMO SAPIENS Primary ovarian insufficiency NBN BRCA2 NUP107 AMHR2 PRORP FMR1 PRDM1 ANTXR1 EIF4ENIF1 MEIOSIN POF1B MEIOB SIL1 NANOS3 ATG9A LARS2 PREPL CLPP MSH4 NOBOX KHDRBS1 BLM AARS2 AIRE ALOX12 MST1R HMMR WDR62 STAR STRA8 SYCE1 SOHLH1 KASH5 SOHLH2 SWI5 EIF2B5 EIF2B2 HELQ FANCM FANCL FANCA FANCC ERAL1 BMP6 DAZL GDF9 DIAPH2 STAG3 H1-8 HROB BMPR1A LHX8 BMPR2 BNC1 MCMDC2 MCM9 LAMC1 HSD17B4 ELAVL2 BMP15 EIF2B1 AMH POLG C1orf146 FIGLA MRPS22 FOXL2 NR5A1 TGFBR3 SIX6OS1 PPM1B HAX1 PCCA FSHR DMC1 PCCB ZP3 CYP17A1 PSMC3IP RECQL4 DCAF17 WRN PGRMC1 SLX4 POLR2C HSD17B1 LMNA CCDC185 MGME1 C10orf2 MND1 CENPE NLRP11 XPNPEP2 SPATA33 WT1 RFWD3 POLR3H NR3A2 SALL4 GNAS SOX8 ZAR1 TP63 NOTCH2 COX10 ATM RAD51 OSTEOARTHRITIC CHONDROCYTE HYPERTROPHY%WIKIPATHWAYS_20260510%WP5373%HOMO SAPIENS Osteoarthritic chondrocyte hypertrophy STAT3 RELA FGFR4 RUNX2 FGFR3 MAPK3 FGFR2 FGFR1 JUND MAPK1 FOSL2 AKT3 KDR NFKB1 FOSL1 CEBPB FOSB RELB CTGF ACAN HIF1A IBSP SPP1 COL10A1 VHL SOX9 CNMD P4HTM NGF GANC JUN COL1A1 VEGFA COL3A1 PIK3CA COL2A1 LAMTOR1 PRKCA DDR2 FGF23 JUNB NTRK1 FOS HALLMARK OF CANCER METASTASIS AND EPITHELIAL TO MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260510%WP5469%HOMO SAPIENS Hallmark of cancer metastasis and epithelial to mesenchymal transition SUZ12 SUV39H1 TCF4 SIRT1 EZH2 TGFB1 SNAI1 HDAC2 FOXC2 HDAC1 PRRX1 KDM1A SIX1 TWIST1 KLF8 ZEB2 ELF3 ELF5 SNAI2 GSC2 GANGLIO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260510%WP5299%HOMO SAPIENS Ganglio series sphingolipid metabolism NEU4 ST8SIA1 HEXB HEXA B3GALT4 ST8SIA5 ST3GAL5 B4GALNT1 ST8SIA6 SIAT4C ST3GAL1 NEU3 AIRWAY SMOOTH MUSCLE CELL CONTRACTION%WIKIPATHWAYS_20260510%WP4962%HOMO SAPIENS Airway smooth muscle cell contraction MYLK CALM1 RYR1 ADRB2 PPP1R14A GDI1 MYL1 IL13 HEL-S-80p PLCB1 ROCK1 ROCK2 ARHA PILOCYTIC ASTROCYTOMA%WIKIPATHWAYS_20260510%WP2253%HOMO SAPIENS Pilocytic astrocytoma NRAS BRAF KRAS RAF1 GRB2 PTPN11 SOS1 HRAS NF1 IL6 SIGNALING%WIKIPATHWAYS_20260510%WP364%HOMO SAPIENS IL6 signaling STAT3 PRDM1 BCL2L1 GRB2 CRP MAPK3 JAK1 TIMP1 CREBBP NR2F6 STAT1 VAV1 IRF1 VIP NCOA1 RPS6KB1 IL6ST MAPK1 RAC1 TYK2 IL6R MAP2K2 PIK3R2 PIK3R1 IL6 SOCS3 BAD NLK PTPN11 SOS1 GSK3B MAP2K4 SHC1 MAP3K7 HDAC1 JUNB MAP2K1 BEMPEDOIC ACID THERAPY IN ATHEROSCLEROSIS AND METABOLIC SYNDROME%WIKIPATHWAYS_20260510%WP5500%HOMO SAPIENS Bempedoic acid therapy in atherosclerosis and metabolic syndrome MAPK12 MAPK10 PRKAA2 MAPK11 HMGA1 ACACA MAPK9 MAPK8 CRP MAPK3 PRKAB2 ACACB MAPK1 PCK2 MAPK14 PRKAB1 G6PC1 G6PC2 G6PC3 SLC27A2 MAPK13 PRKAG1 PRKAG2 PRKAA1 PRKAG3 ACLY ERYTHROPOIESIS%WIKIPATHWAYS_20260510%WP5607%HOMO SAPIENS Erythropoiesis EPOR CD79A KITLG TF PTPRC HBZ IL3 IL3RA CD34 HBG2 TNFSF6 HBG1 KIT HBE1 HBB HBA2 HBD GATA1 FAS GATA2 GDF11 TFRC EPO DISORDERS OF BILE ACID SYNTHESIS AND BILIARY TRANSPORT%WIKIPATHWAYS_20260510%WP5176%HOMO SAPIENS Disorders of bile acid synthesis and biliary transport CYP7A1 CYP8B1 ABCC3 HSD3B7 ABCC2 ABCB1 ABCD3 ABCB4 SLC10A2 AKR1D1 SLC51A AKR1C4 BAAT SLC51B ABCB11 CYP7B1 CYP27A1 SLCO1B1 ATP8B1 AMACR FABP6 SLC27A5 HSD17B4 SLC27A2 MITOCHONDRIAL IMMUNE RESPONSE TO SARS COV 2%WIKIPATHWAYS_20260510%WP5038%HOMO SAPIENS Mitochondrial immune response to SARS CoV 2 CTSL IKBKE TICAM1 IRF3 IRF7 TLR7 TLR3 RIGI TRAF6 AGTR1 TOMM70 AGTR2 NLRX1 ACAD9 NFKB1 ECSIT MITA ACE2 MAVS TRAF3 REN NDUFAF1 NFKB2 NDUFB9 TMPRSS2 CGAS PHB2 IFIH1 TBK1 SERINE METABOLISM%WIKIPATHWAYS_20260510%WP4688%HOMO SAPIENS Serine metabolism TYMS SRR PSAT1 PHGDH HEL-S-51e PSPH DHFR SHMT1 ARACHIDONIC ACID AA ARA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260510%WP5155%HOMO SAPIENS Arachidonic acid AA ARA oxylipin metabolism EPHX2 PTGS2 PTGS1 ARSENIC METABOLISM AND REACTIVE OXYGEN SPECIES GENERATION%WIKIPATHWAYS_20260510%WP5233%HOMO SAPIENS Arsenic metabolism and reactive oxygen species generation ND1 COA3 HEL-S-44 ATP1A1 SDHA AS3MT HEL-S-21 UQCRFS1 G PROTEIN SIGNALING%WIKIPATHWAYS_20260510%WP35%HOMO SAPIENS G protein signaling PRKD1 GNAZ PRKCZ GNG12 GNG11 GNG13 GNAO1 GNB2 PPP3CA GNB1 GNAS ARHA HRAS GNB3 GNB5 CALM1 PRKACG GNGT1 PLCB3 GNAI3 ADCY3 ADCY1 ADCY8 GNAI1 ADCY6 GNG3 GNG5 GNG4 GNG7 GNA11 KRAS GNG8 KCNJ3 HEL159 AKAP12 AKAP10 AKAP11 GNGT2 PPP3CC RRAS PDE4B ARHGEF1 PDE4A PDE8A PDE4D PRKD3 AKAP9 PDE1C PDE1B PDE1A GNA13 AKAP8 AKAP7 AKAP6 AKAP5 AKAP4 NRAS GNA14 GNA15 GNG10 GNAL PDE7B PDE7A PRKCH PRKCB PRKCE PRKCA PRKCI ADCY9 PRKAR1B PRKAR1A PRKCQ PYRIMIDINE METABOLISM%WIKIPATHWAYS_20260510%WP4022%HOMO SAPIENS Pyrimidine metabolism POLR2B POLD2 POLR2D NT5M POLR2G POLR2I POLR2J POLR2J3 ZNRD1 DUT PNPT1 POLR2J2 POLR3GL POLE4 UCK2 POLA2 UCK1 POLR1A POLR3A POLR1C POLR3B POLR1D POLR3C POLR1F POLR3D POLE3 POLR3E POLR3F POLR3G POLR3K POLR2H POLR2K POLR2L POLE DPYS CAD PRIM1 TYMP TYMS DHODH POLD3 RRM2B DPYD HEL74 UMPS POLR2C RRM1 RRM2 POLA1 POLE2 POLR3H CDA ENPP1 ENPP3 TK1 ENTPD1 ENTPD3 NME2 NME3 CTPS2 CTPS1 NME4 DCTD NME6 NME7 CMPK1 CMPK2 UPRT DCTPP1 PRIM2 POLD4 DTYMK POLR2A SNARE COMPLEX MACHINERY IN EXOCYTOSIS%WIKIPATHWAYS_20260510%WP5621%HOMO SAPIENS SNARE complex machinery in exocytosis STX1B RIMS1 CACNA1B STXBP5 CACNA1A STXBP6 VAMP2 GDI1 NAPA SNAP25 UNC13A SYT1 STXBP1 SYP CPLX1 RPH3A ACETAMINOPHEN IN ANALGESIA AND ANTIPYRESIS%WIKIPATHWAYS_20260510%WP5444%HOMO SAPIENS Acetaminophen in analgesia and antipyresis FAAH TRPA1 KCNQ2 CACNA1H KCNQ3 TRPV1 PTGS2 5HT1A PTGS1 EICOSANOID METABOLISM VIA LIPOOXYGENASES LOX %WIKIPATHWAYS_20260510%WP4721%HOMO SAPIENS Eicosanoid metabolism via lipooxygenases LOX TRPA1 CYP4A11 ALOX15 EHHADH TRPV1 HEL-S-298 HPGD CYP4F2 CYP4A22 FPR2 LTC4S PTGR1 ALOX15B CYP4F12 LTB4R NR1C2 KPG_011 ALOX5 ACOX3 ACOX1 ALOX12 NR1C1 ETHANOL METABOLISM PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20260510%WP4269%HOMO SAPIENS Ethanol metabolism production of ROS by CYP2E1 MAP2K2 NFE2L2 MAFG MAFF MAFK MAP2K1 MAPK8 CYP2E1 SP1 EXTRACELLULAR VESICLES IN THE CROSSTALK OF CARDIAC CELLS%WIKIPATHWAYS_20260510%WP4300%HOMO SAPIENS Extracellular vesicles in the crosstalk of cardiac cells EGF STAT3 TLR4 IL6 HEL-S-44 SPP1 BIRC5 PTEN EGFR CD63 HEL-S-102 CD81 GATA4 KDR IGF1 MMP9 ETS2 GLP 1 SECRETION FROM INTESTINE TO PORTAL VEIN%WIKIPATHWAYS_20260510%WP5446%HOMO SAPIENS GLP 1 secretion from intestine to portal vein SLC2A2 GCG SLC5A1 PCSK1 COVID 19 ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260510%WP4891%HOMO SAPIENS COVID 19 adverse outcome pathway CCL3 CCL2 TNF CSF3 ACE2 IL7 IL6 IL10 CXCL8 IL2RA IL1B IL2 TMPRSS2 POLYCYSTIC KIDNEY DISEASE PATHWAY%WIKIPATHWAYS_20260510%WP2571%HOMO SAPIENS Polycystic kidney disease pathway PRKAA2 PLCG2 FLT1 MAPK3 IGF1R BRAF CCND1 MYC KDR GNAS HRAS MAP2K2 CTNNB1 TSC2 TSC1 PRKACG DVL1 DVL2 JUN DVL3 WNT4 SRC WNT1 GNAI3 IGF1 GNAI1 ADCY6 EGF MTOR WNT2B FZD10 PKD1 RHEB WNT5B WNT9B GNA11 WNT9A KRAS WNT16 FZD1 SSTR2 SFRP4 CFTR WNT8A WNT8B KCNN4 IKBKB WNT3 WNT10B WNT10A FZD3 PRKAB2 FZD2 FZD5 PRKAB1 FZD4 WNT3A WNT7B FZD7 FZD9 VEGFB WNT7A PDE1A FZD8 STK11 TNF NRAS RPS6KA1 PRKAG1 PRKAG2 PRKAG3 PRKAA1 GSK3B SLC12A2 FOS ERBB2 SLEEP REGULATION%WIKIPATHWAYS_20260510%WP3591%HOMO SAPIENS Sleep regulation CRH DLAT HTR2A NLGN1 IL18 STAR OXTR NPY2R OXT NPAS2 TH NPS CACNA1I IL6 HEL-S-2 DRD1 DRD2 DRD3 PTGDR CHRNB2 UTS2R MRGPRX2 BTBD9 HCRTR2 HCRTR1 PER3 ADORA2A MTNR1B GHRH UTS2 GHRL SLC29A1 ADA FOS FUMARATE HYDRATASE DEFICIENT PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260510%WP4241%HOMO SAPIENS Fumarate hydratase deficient papillary renal cell carcinoma SFPQ CTSK COL21A1 EP300 ELOC BIRC7 HIF1A RBX1 VHL CDKN1A DVL2 VEGFA CREBBP TGFB1 EGLN1 FH EGLN3 SETD2 TGFA EGLN2 CADM2 PRCC TFEB SMITH MAGENIS AND POTOCKI LUPSKI SYNDROME COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5381%HOMO SAPIENS Smith Magenis and Potocki Lupski syndrome copy number variation CREB1 YAP1 NT5M TLR4 RELA PRDM1 SHMT1 BLM CDC2 ARHA CFL2 JUN TRAF3IP1 IFT172 IFT52 PCK1 IFT57 IFT56 IFT80 IFT81 HEL-S-133P ROCK1 MAP3K14 NFKB1 IFT46 IFT70B LIMK1 IFT74 APP PARD3 TFEB IFT20 FOXA1 FHOD1 BCL6 IFT27 PARK2 BCL2L11 FERD3L GRIP1 ALKBH5 MAEA PPP1R14A CLUAP1 DENR PARD6B HES6 IFT25 MIGA1 MED9 ARMC8 RNF41 TOM1L2 PTEN RRAGA ULK1 LLGL1 DRC5 RPTOR DRC7 DRC8 FLII G6PC1 MYC GPR85 CLEC16A COPS7A PLD6 MLST8 NR1H3 RAI1 ATG101 WWTR1 TNFSF13 RAB39B COPS4 COPS6 IFT22 CRY1 COPS5 PEMT DRC1 COPS8 MYD88 CLTC GDI2 CLTB WDR41 CLTA FLCN PER1 RB1CC1 RAB8A ATPAF2 ARG2 RMI2 RMI1 TOP3A ITPK1 ETV5 DRC10 MYH2 TACI CRY2 IRF8 SMCR8 C9orf72 WDR26 GPS1 STAT3 MIEF2 RASD1 MTOR RMND5A FNIP1 FNIP2 RANBP9 MYO16 RAB10 MKLN1 GID4 MYO15A CARM1 DRG2 FOXA2 IL1B PRKAB1 TNF BIRC2 PRKAG2 PRKAA1 BAX PRKCI NR1H2 PRION DISEASE PATHWAY%WIKIPATHWAYS_20260510%WP3995%HOMO SAPIENS Prion disease pathway CREB1 EP300 STAT3 FYN NCAM1 MAPK3 SPI1 FGFR1 CTCF CHD2 HEL-S-125m HEL-S-89n TBP RAD21 HEL-S-269 MAPK1 PAX5 POU2F2 RFX5 NFKB1 BCL2 IRF4 RXRA CASP12 PRNP CASP3 BCL11A BATF SMC3 MEF2C VEDOLIZUMAB THERAPY FOR INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260510%WP5512%HOMO SAPIENS Vedolizumab therapy for inflammatory bowel disease ITGA4 VCAM1 ITGB1 SELPLG ITGA2 MADCAM1 ITGB7 SELE WHITE FAT CELL DIFFERENTIATION%WIKIPATHWAYS_20260510%WP4149%HOMO SAPIENS White fat cell differentiation CREB1 IRF3 TCF7L1 NR3C1 PPARG KLF4 STAT5B WNT10B RORA NR1H3 CEBPA CEBPD CTNNA1 EVI1 CEBPB ZNF423 TLE3 IRF4 EGR2 GATA3 NR2F2 KLF15 KLF2 KLF5 RARA DDIT3 FOXO1 GATA2 INS INFLUENZA A VIRUS INFECTION%WIKIPATHWAYS_20260510%WP1438%HOMO SAPIENS Influenza A virus infection BCL2 PHOTODYNAMIC THERAPY INDUCED HIF 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260510%WP3614%HOMO SAPIENS Photodynamic therapy induced HIF 1 survival signaling MCL1 NOS2 BCL2L1 BIRC5 IGFBP1 HEL-S-30 HEL-S-133P HEL-S-68p EPO ANGPT2 ANGPT1 HIF1A BAK1 BCL2A1 SLC2A3 PTGS2 PMAIP1 HIF1AN BNIP3L EDN1 IGFBP2 BAX VEGFA PFKL EGLN1 PDHA1 TGFA BNIP3 GLUTATHIONE METABOLISM%WIKIPATHWAYS_20260510%WP100%HOMO SAPIENS Glutathione metabolism GPX4 GPX2 GPX1 GPX3 HEL-S-64p GSTM2 GSTM1 GSTT2 OPLAH HEL-75 GCLC GSTA5 GCLM HEL-S-26 ULCERATIVE COLITIS SIGNALING%WIKIPATHWAYS_20260510%WP5174%HOMO SAPIENS Ulcerative colitis signaling IFNG TNF GATA3 IL2RG HLA-DMA IL13 NFATC1 IL10 IL4 TGFB1 NOD2 NFKB1 IL5 MAF FOXP3 MAP3K1 ROLE IN PROMOTING AND BLOCKING GONADAL DETERMINATION%WIKIPATHWAYS_20260510%WP4872%HOMO SAPIENS MAP3K1 role in promoting and blocking gonadal determination CTNNB1 FOXL2 MAPK11 FGF9 SOX9 FRAT1 GADD45G GSK3B FGFR2 WNT4 MAP3K1 AXIN1 MAPK1 ROCK1 ARHA SRY NEURAL CREST CELL MIGRATION DURING DEVELOPMENT%WIKIPATHWAYS_20260510%WP4564%HOMO SAPIENS Neural crest cell migration during development ARF1 EPHB2 PAK4 EPHB1 STAT3 TRIO EPHB4 EPHB3 TIAM1 CDH11 F2RL2 PIK3CD RAC1 AKT3 MMP2 MMP9 ARHA PIK3R3 BDNF PAK1 JUN PIK3CA TWIST1 PIK3R4 NGFR PIK3R5 FOS EPHB6 PAK6 METABOLIC REPROGRAMMING IN COLON CANCER%WIKIPATHWAYS_20260510%WP4290%HOMO SAPIENS Metabolic reprogramming in colon cancer SUCLG2 GLS HK3 PSAT1 SLC16A3 HEL-S-51e TIGAR PSPH HEL107 PGAM1 PYCR2 PAICS SDHB RPIA GLUD1 ACO2 ALDOB HEL-S-30 HEL-S-133P ENO1 HEL-S-68p HEL-S-162eP MDH2 GOT2 PFKL FASN FH PDHA1 ACLY CELL TYPE DEPENDENT SELECTIVITY OF CCK2R SIGNALING%WIKIPATHWAYS_20260510%WP3679%HOMO SAPIENS Cell type dependent selectivity of CCK2R signaling GNAI1 RYR1 RYR2 DAGLA CNR1 TRPC1 CCK RYR3 CCKBR PLCB1 NEURODEGENERATION WITH BRAIN IRON ACCUMULATION NBIA SUBTYPES PATHWAY%WIKIPATHWAYS_20260510%WP4577%HOMO SAPIENS Neurodegeneration with brain iron accumulation NBIA subtypes pathway MTOR RHEB ACACA DCAF17 ULK1 RPTOR DEPTOR PANK2 PLA2G6 WDR45 SPTLC1 MAP1LC3A MLST8 ATG5 ATG101 ATG3 STK11 ATG10 WIPI1 WIPI2 TSC2 C19orf12 TSC1 ATG14 CP COASY ATG12 FA2H ATG16L1 AKT1S1 PRKAA1 ATG2A FTL RB1CC1 PIK3R4 ONE CARBON METABOLISM%WIKIPATHWAYS_20260510%WP241%HOMO SAPIENS One carbon metabolism TCN2 MTR HEL-S-51e MTFMT AHCYL2 HEL-S-70p SHMT1 HEL-S-61p AMT GLRX TYMS MTHFS MAT1A FTCD FOLH1 MTHFD1L MTHFD1 MTHFD2 CHDH DNMT3B MTRR DHFR IL1 AND MEGAKARYOCYTES IN OBESITY%WIKIPATHWAYS_20260510%WP2865%HOMO SAPIENS IL1 and megakaryocytes in obesity HEL-S-134P IFNG CCL2 NLRP3 MYD88 F2R IL1R1 PIK3CA TIMP1 IL1B F2 HBEGF PLA2G7 TLR1 NFKB1 IRAK1 IL18 MMP9 FCER1A S100A9 CCR3 FGFR3 SIGNALING IN CHONDROCYTE PROLIFERATION AND TERMINAL DIFFERENTIATION%WIKIPATHWAYS_20260510%WP4767%HOMO SAPIENS FGFR3 signaling in chondrocyte proliferation and terminal differentiation CNP THRA NPR2 FGF18 IHH MAPK12 PTH1R PTHLH MAPK11 CDKN1A FGFR3 MAPK3 BMP4 SNAI1 STAT1 MAPK1 MAPK14 RAF1 MAPK13 ATG5 PPP2CA MAP2K2 FGF9 RBL1 SOX9 BMP2 MAP2K1 FGF23 SIGNALING IN HYPOPHOSPHATEMIC RICKETS AND RELATED DISORDERS%WIKIPATHWAYS_20260510%WP4790%HOMO SAPIENS FGF23 signaling in hypophosphatemic rickets and related disorders SLC34A3 KL GALNT3 SPP1 PTH SLC34A1 DMP1 CYP27B1 ENPP1 CYP24A1 CDKN1A FAM20C ALPL FGFR3 ROS1 FGFR2 NFKB2 FGF23 CCND1 CYP11B2 NFKB1 ORAI1 PI3K AKT MTOR SIGNALING AND THERAPEUTIC OPPORTUNITIES IN PROSTATE CANCER%WIKIPATHWAYS_20260510%WP3844%HOMO SAPIENS PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer MTOR RHEB KRAS FOXO3A FOXO4 PTEN GRB10 ULK1 RPTOR MLST8 HRAS PIK3R3 PIK3R2 PIK3R1 TSC2 NRAS BAD MAPKAP1 RICTOR GSK3B RB1CC1 PIK3CA CDKN1B FOXO1 EIF4EBP1 TFEB SARS COV 2 INNATE IMMUNITY EVASION AND CELL SPECIFIC IMMUNE RESPONSE%WIKIPATHWAYS_20260510%WP5039%HOMO SAPIENS SARS CoV 2 innate immunity evasion and cell specific immune response EP300 CSF2 CXCL13 CASP8 FADD IL10 JAK1 TFAP2A TGFB1 STAT1 CCL5 IL6R CCL4 CCL3 CCL2 CXCL11 CXCL12 HDAC2 TBK1 IRF3 IRF7 TLR7 RIGI CXCL6 CXCL9 IFITM1 TRADD CXCL17 TRAF6 CXCL1 CXCL3 CXCL2 CXCL5 IFIT2 NFKB1 AP1G1 DHX58 TRIM25 HAVCR2 IFNAR2 TNF LAG3 TRAF2 ACE2 hEMMPRIN MAVS TRAF5 IL6 TRAF3 NUP98 IFNAR1 TANK IL8RB LARP1 RIPK1 RAE1 IFNB1 CD160 STAT2 CXCL8 MX1 PPBP TP53I3 PF4 MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260510%WP4190%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway HMGCS1 HMGCR IDI1 FDPS MVK GGPS1 IDI2 ACAT2 ACAT1 HMGCL PMVK MVD FDFT1 KIT RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP304%HOMO SAPIENS Kit receptor signaling RPS6KA3 INPP5D EP300 SOCS6 STAT3 SH2B2 FYN MATK GAB2 PTPN6 DOK1 TEC GRB2 MAPK8 PLCG1 FOXO3A MAPK3 LYN GRB10 STAT5B STAT1 VAV1 RPS6 RPS6KB1 MAPK1 MAPK14 BTK RAF1 SOCS1 HRAS MAP2K2 PIK3R2 KITLG PIK3R1 RPS6KA1 KIT BAD CRKL PTPN11 SOS1 SHC1 PRKCB SRC PRKCA CRK MAP2K1 CBL GRB7 TRANSCRIPTIONAL ACTIVATION BY NRF2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20260510%WP3%HOMO SAPIENS Transcriptional activation by NRF2 in response to phytochemicals EPHB2 CEBPB SLC7A11 AIMP2 HMOX1 MAPK8 PIK3CA PRKCA NFE2L2 NQO1 GCLC GCLM MAF KEAP1 MICROGLIA PATHOGEN PHAGOCYTOSIS PATHWAY%WIKIPATHWAYS_20260510%WP3937%HOMO SAPIENS Microglia pathogen phagocytosis pathway PTPN6 NCF1 NCF2 ARPC1B VAV2 NCF4 PLCG2 RAC3 TREM2 TREM1 NCKAP1L LYN FCGR1A PIK3CD VAV3 SYK FCER1G VAV1 CYBB CYBA ITGAM TYROBP SIGLEC7 RAC1 C1QC PIK3R3 PIK3R2 PIK3R1 C1QA PIK3CA LAT C1QB PIK3C2A CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260510%WP5304%HOMO SAPIENS Cholesterol metabolism PCSK9 MSMO1 LIPA APOA2 TM7SF2 APOC3 LIPG CD36 STAR LBR PBR STARD3 CYP7A1 MYLIP ABCG8 ABCG5 DGAT1 SCARB1 NPC1 LIPC SOAT1 NPC2 LPL APOA4 ANGPTL8 ANGPTL3 PLTP LPA LDLR SLC27A4 LRPAP1 SAR1B MTTP HSD17B7 EBP NPC1L1 ABCB11 APOH SC5D CYP27A1 MGAT1 APOB SORT1 CIDEB DHCR24 FABP2 SQLE VAPA APOC2 APOC1 APOE ABCA1 DHCR7 HMGCS1 HMGCR IDI1 FDPS MVK ACAT2 PMVK MVD FDFT1 CYP51A1 MACROPHAGE MARKERS%WIKIPATHWAYS_20260510%WP4146%HOMO SAPIENS Macrophage markers CD163 CD83 CD68 LYZ F3 CD14 CD74 ANDROGEN RECEPTOR NETWORK IN PROSTATE CANCER%WIKIPATHWAYS_20260510%WP2263%HOMO SAPIENS Androgen receptor network in prostate cancer CHEK1 MRE11A CDC25B MAPK8 PRKDC MAPK3 HSD3B2 HSD3B1 BLM MAPK14 SMAD2 PLK1 CDC2 SP1 CDK2 BCL2 ATR PXN JUN PIK3CA RB1 SMARCD1 SMARCD2 SMARCD3 HSD17B4 CDKN2B SMARCC1 SMARCC2 ACTL6B CDKN2A ACTL6A ARID1A ARID1B MSH6 SMARCA4 CYP17A1 CDK4 BARD1 HSD17B1 MAPK1 DOCK1 RAF1 RAP1A FOXA1 CASP8 CDKN1A JAK1 PTEN STAT1 RPTOR CCND1 MYC HRAS MAP2K2 TSC2 TSC1 CRKL SOS1 HSD17B7 CRK EIF4EBP1 STAT3 MTOR SPINK1 HGF MSH2 RHEB BRCA1 EIF4E1B ERG MDM2 FKBP5 KLK3 GRB2 NOXA1 F13B MAP4K1 ATF1 ETV4 RAPGEF1 HSD17B3 CPN1 HSD17B2 PTK2B SPRY2 SPRY1 PAK1 BAD PTPN11 RICTOR BAX CASP9 CDKN1B ATM CASP3 MAP2K1 FOS RAD50 CHEK2 DIFFERENTIATION OF WHITE AND BROWN ADIPOCYTE%WIKIPATHWAYS_20260510%WP2895%HOMO SAPIENS Differentiation of white and brown adipocyte PRDM16 HOXC9 HOXC8 CEBPB ZNF423 PPARGC1B MPZL2 SMAD1 SMAD9 BMP2 PPARG DKFZp781O1323 BMP4 DGIC CEBPG HSPB7 CIDEA EBF3 SLC7A10 BMP7 LEP PPARGC1A CEBPA ZIC1 GLUCOSE METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260510%WP5211%HOMO SAPIENS Glucose metabolism in triple negative breast cancer cells PPM2C PFKP HEL-S-30 HEL-S-133P SMC1 SMC3 ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260510%WP5118%HOMO SAPIENS SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome MRE11A NBN ATM SMC1A PAXIP1 RAD21 BRCA1 SMC3 RAD18 MDC1 RAD50 SEROTONIN AND ANXIETY%WIKIPATHWAYS_20260510%WP3947%HOMO SAPIENS Serotonin and anxiety CRH HTR2A ARC FMR1 PLEK ADRA1A TRPV1 EEF2K PLCD4 5HT1A PRKCB POMC PPP3CA FOS CONVERSION OF ANGIOTENSINOGEN TO ANGIOTENSIN II %WIKIPATHWAYS_20260510%WP4818%HOMO SAPIENS Conversion of angiotensinogen to angiotensin II CTSG CMA1 HEL-S-130P REN SMALL LIGAND GPCRS%WIKIPATHWAYS_20260510%WP247%HOMO SAPIENS Small ligand GPCRs PTGDR PTGER4 PTGFR PTGIR PTGER1 PTGER2 PTGER3 LPAR1 GPR50 MTNR1A MTNR1B CNR2 TBXA2R CNR1 S1PR1 S1PR3 S1PR2 S1PR4 DOCOSAHEXAENOIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260510%WP5154%HOMO SAPIENS Docosahexaenoic acid oxylipin metabolism EPHX2 PTGS2 MIR 124 PREDICTED INTERACTIONS WITH CELL CYCLE AND DIFFERENTIATION %WIKIPATHWAYS_20260510%WP3595%HOMO SAPIENS mir 124 predicted interactions with cell cycle and differentiation STK11 PTBP1 PRKAA1 SIX4 CTDSP1 STRADB 15Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP4940%HOMO SAPIENS 15q11 2 copy number variation syndrome NIPA1 TUBGCP6 TUBGCP4 NIPA2 FMR1 CYFIP1 TUBGCP5 THIAMINE METABOLIC PATHWAYS%WIKIPATHWAYS_20260510%WP4297%HOMO SAPIENS Thiamine metabolic pathways OGDH BCKDK TPK1 SLC19A3 DKFZp667O1614 SLC19A2 PDHA1 HEL107 MOLECULAR PATHWAY FOR OXIDATIVE STRESS%WIKIPATHWAYS_20260510%WP5477%HOMO SAPIENS Molecular pathway for oxidative stress CREB1 CHEK1 MAP2K3 MTOR RHEB NRF1 MDM2 HMOX1 GSX1 NOS2 BCL2L1 IPCEF1 MAPK8 PINK1 PIP CDKN1A IL1A PTEN IKBKB RPS6KA5 NQO1 MAPK14 IKBKG NFKB1 KEAP1 CDK2 BCL2 TNF ATR TSC1 IL6 SIRT1 PTGS2 MAP2K4 CXCL8 PIK3CA CCNE1 NFE2L2 FOXO1 MAP3K5 ATF2 FOS NOTCH1 REGULATION OF ENDOTHELIAL CELL CALCIFICATION%WIKIPATHWAYS_20260510%WP3413%HOMO SAPIENS NOTCH1 regulation of endothelial cell calcification NOTCH1 GJA5 JAG2 PLAT ALPL FGFR3 ITGA1 DLL3 LPAR1 VEGFA DLL4 MGP CALU SOX6 PHOSPHATIDYL INOSITOL PHOSPHATE PATHWAY%WIKIPATHWAYS_20260510%WP5411%HOMO SAPIENS Phosphatidyl inositol phosphate pathway INPP5D STM7 PLCD4 PLCG2 PLCG1 PLCB1 PTEN PIK3CD MTMR1 PI4K2B MTMR2 MTMR8 OCRL MTMR6 MTM1 PIP4P2 PLCB2 PIP4P1 PLCE1 TPTE2 SACM1L IPMK FIG4 INPP4A INPP4B PIKFYVE PLCB4 PI4KB PIP4K2A PLCD3 PIP4K2B INPP5E PLCB3 PIK3CA PIP5K1A PIP5K1C PIK3C2G PI4K2A PIK3C2A PIK3C2B MAMMALIAN DISORDER OF SEXUAL DEVELOPMENT%WIKIPATHWAYS_20260510%WP4842%HOMO SAPIENS Mammalian disorder of sexual development WT1 CTNNB1 FOXL2 NR5A1 MAPK11 FGF9 AMHR2 EMX2 RBFOX2 DMRT1 PBX1 DHH SOX9 CBX2 FST SOX8 RSPO1 INSL3 FGFR2 WNT4 GATA4 SRY AMH MITOCHONDRIAL FISSION AND FUSION%WIKIPATHWAYS_20260510%WP4318%HOMO SAPIENS Mitochondrial fission and fusion FIS1 BAX MTFP1 MFN1 MFN2 SH3GL2 BCL2L1 OPA1 BNIP3 MIB1 MICRORNA FOR TARGETING CANCER GROWTH AND VASCULARIZATION IN GLIOBLASTOMA%WIKIPATHWAYS_20260510%WP3593%HOMO SAPIENS MicroRNA for targeting cancer growth and vascularization in glioblastoma HES1 VEGFA VEGFC HIF1A VEGFB HIF1AN MAMMARY GLAND DEVELOPMENT INVOLUTION STAGE 4 OF 4%WIKIPATHWAYS_20260510%WP2815%HOMO SAPIENS Mammary gland development involution stage 4 of 4 BAX STAT3 CHI3L1 IL6ST SOCS3 MYC MMP9 SIGNAL TRANSDUCTION THROUGH IL1R%WIKIPATHWAYS_20260510%WP4496%HOMO SAPIENS Signal transduction through IL1R IL1RN MAP2K3 RELA MAPK8 IL1R1 IL1A IKBKB TGFB1 IL1B NFKBIA MAP3K1 CHUK TRAF6 MAPK14 MAP3K14 NFKB1 MAP2K6 ECSIT TNF IL6 MYD88 IFNB1 JUN MAP3K7 IFNA1 IRAK2 IRAK3 MAP3K7IP1 IRAK1 CHEMOKINE SIGNALING%WIKIPATHWAYS_20260510%WP3929%HOMO SAPIENS Chemokine signaling TIAM1 CXCL13 RELA JAK3 MAPK3 BRAF PRKACG PLCB4 PXN PIK3CA CXCL14 CXCL16 PREX1 ELMO1 GRK1 CCR3 CCR10 CCR1 XCR1 NFKBIB WASL CCR8 CCR7 CCR6 CCR4 CCR2 XCL1 DOCK2 CCL11 CXCR5 PRKX CXCR6 ADRBK1 CCL1 IKBKB CCL19 NFKBIA CCL17 CXCL9 VAV1 CCL15 CHUK CCL25 CCL24 CCL22 MAPK1 CCL21 CXCL3 IKBKG CCL20 RAF1 ROCK1 c-fgr CXCL5 ROCK2 CCL28 NFKB1 WAS CCL26 CX3CL1 CDC42 CSK IL8RB CCL27 PARD3 STAT2 RAP1A PPBP PRKCB PF4 ADCY9 CX3CR1 PIK3R5 PRKCZ GRK5 NCF1 GRK4 GNG12 FOXO3A GNG11 PLCB1 GNG13 LYN STAT5B PIK3CD VAV3 STAT1 GNB2 CXCR4 AKT3 GNB1 CCL7 GNB4 CCL5 GNB3 HRAS CXCR3 GNB5 CCL4 CCL3 CXCL11 ARRB2 CXCL12 GNGT1 CRKL SOS1 SOS2 PLCB3 SHC1 CRK SHC4 SHC3 GNAI3 ITK ADCY3 ADCY1 ADCY8 GNAI1 ADCY6 STAT3 GNG3 GNG2 GNG5 GNG4 GNG7 KRAS GRB2 GNG8 VAV2 PTK2B GNGT2 RAC1 PLCB2 SHC2 PIK3R3 PIK3R2 PIK3R1 NRAS PAK1 GNG10 GSK3B MAP2K1 FATTY ACID AND LIPOPROTEIN TRANSPORT IN HEPATOCYTES%WIKIPATHWAYS_20260510%WP5323%HOMO SAPIENS Fatty acid and lipoprotein transport in hepatocytes SLC27A1 PCSK9 LIPA SLC27A2 ACSL6 ACSL5 STAR DBI FABP4 APOE SOAT2 ABCA1 STARD3 SLC27A3 MYLIP FABP1 SCARB1 SOAT1 NPC2 APOA4 LDLR LPA SLC27A4 ACSL1 ACSL3 APOB SORT1 FABP2 APOC2 APOC1 SREBF AND MIR33 IN CHOLESTEROL AND LIPID HOMEOSTASIS%WIKIPATHWAYS_20260510%WP2011%HOMO SAPIENS SREBF and miR33 in cholesterol and lipid homeostasis ABCA1 MED15 MTOR SIRT1 PRKAA1 LDLR HMGCS1 SREBF2 HMGCR SCD FASN NR1H3 NR1C1 SIRT6 PPARGC1A 2Q37 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP5224%HOMO SAPIENS 2q37 copy number variation syndrome ARF1 UGT1A4 HES1 UGT1A3 UGT1A7 UGT1A1 MAP1LC3A JUN TRAF3IP1 MEF2C NFKBIA MROH2A UGT1A10 DGKD NDUFA10 HJURP ERFE KLHL30 IL13RA1 GABARAPL2 GABARAPL1 EEF1A1 THAP4 RRAGB RRAGD CALCA CALCRL TWIST2 AGAP1 GABARAP OR6B3 MAP4 TRPM8 OR6B2 UBE2F MTERF4 RAB27A HAMP COPS9 SNED1 NEU4 RTP5 RNPEPL1 PRH PRL ING5 GYS1 SEPT6 MAP1LC3C KIF1A GAL3ST2 ILKAP BOK MYOG HES6 AQP12B AQP12A DUSP28 ANO7 OTOS HEL-S-28 RRAGA ARL4C MYOD1 RPS6 DKFZp762B153 USP40 AGXT ARF5 CXCR4 NEDD8 ASCL1 ASB18 CENPA CYTH2 GBX2 PPP1R7 GPC1 CALM1 SH3BP4 SPP2 D2HGDH DISC1 UGT1A8 CXCL11 ANKMY1 CXCL12 CYTH1 FARP2 COPS8 UGT1A9 PDX1 SEPTIN4 PER2 MLPH CAPN10 ACKR3 RAB17 RAMP1 ASB1 ITGB3 EGFR ITPK1 IRF8 PDCD1 PDGFA IL1B SEPTIN2 RAC1 ABCA1 TNF TRAF3 DTYMK ACUTE MYELOID LEUKEMIA%WIKIPATHWAYS_20260510%WP5293%HOMO SAPIENS Acute myeloid leukemia CSF2 RELA FLT3 MAPK3 FCGR1A STAT5B PIK3CD NR1C2 JUP RPS6KB1 BRAF RPS6KB2 CCND1 MYC AKT3 HRAS RUNX1 MAP2K2 IL3 CCNA2 KIT RARA PER2 SOS1 SOS2 PIK3CA CSF1R MPO TCF7L2 PIM1 PIM2 LEF1 CEBPE CD14 RUNX1T1 EIF4EBP1 ZBTB16 STAT3 PML TCF7L1 MTOR KRAS GRB2 SPI1 IKBKB ARAF CHUK ITGAM MAPK1 IKBKG RAF1 NFKB1 CEBPA PIK3R3 PIK3R2 PIK3R1 NRAS BCL2A1 BAD MAP2K1 PANCREATIC CANCER SUBTYPES%WIKIPATHWAYS_20260510%WP5390%HOMO SAPIENS Pancreatic cancer subtypes TSPAN8 VSIG2 AGR2 AGR3 LYZ FAM3D TNS4 KRT6C FAM83A KRT6A SERPINB3 BTNL8 FGFBP1 S100A2 TFF2 REG4 KRT7 ANXA10 LEMD1 DHRS9 CEACAM6 SCCA2 PLA2G10 LY6D TFF3 TFF1 VGLL1 CLRN3 CDH17 SPRR1B AREG SPRR3 ANXA8L1 ST6GALNAC1 GPR87 HEL136 KRT20 CST6 CYP3A7 LGALS4 SCEL EXTRACELLULAR VESICLE MEDIATED SIGNALING IN RECIPIENT CELLS%WIKIPATHWAYS_20260510%WP2870%HOMO SAPIENS Extracellular vesicle mediated signaling in recipient cells TSPAN8 CTNNB1 TGFBR2 MTOR NRAS TGFBR3 HGF APC KRAS MET TGFB1 MFGE8 AXIN1 EGFR SMAD2 WNT3A SMAD4 RAF1 TGFA DKK4 CD133 HRAS TGFBR1 ERBB2 MRNA PROCESSING%WIKIPATHWAYS_20260510%WP411%HOMO SAPIENS mRNA processing DHX38 SRPK2 CPSF4 CPSF1 FUS CPSF3 NONO CPSF2 SUPT5H WDR57 SFRS3 CLK4 LSM2 CLK2 SRPK1 HNRNPL CLK1 LSM7 HNRNPK HNRNPD RNPS1 CLASRP HNRNPC DKFZp434N041 SUGP2 SUGP1 CELF1 CELF2 CELF4 SRP54 YBX1 DHX15 DHX16 RBM5 RBM17 NCBP1 NCBP2 PRMT1 PRPF40A SMC1A PRPF18 NHP2L1 HNRNPH1 SNRPA1 DNAJC8 SF3B5 SF3B2 RNMT CSTF2T U2AF1 PPM1G PABPN1 U2AF2 TRA2B SPOP SNRPB2 SF3B1 SRSF10 SF3A1 SF3A2 NUDT21 PHF5A HNRNPA2B1 RBMX PRMT2 DICER1 SFPQ HNRNPAB SNRPD2 SNRPD1 HNRPR CLP1 PAPOLA SNRPD3 TXNL4A PSKH1 SNRPN METTL3 PRP4K CDC40 PRPF4 PRPF6 PRPF3 SNRPG SRSF4 SNRPE SNRPF SREK1 SRSF6 SRSF7 SNRPA SNRPB SRSF9 TMED10 DHX8 DDX1 CSTF3 PTBP1 CSTF2 PRPF8 SFRS5 SFRS8 CSTF1 POLR2A HISTONE MODIFICATIONS%WIKIPATHWAYS_20260510%WP2369%HOMO SAPIENS Histone modifications SETD4 SUV39H2 SETD5 SUV39H1 SET SETD3 KMT2A H3C15 H3F3B SETD8 SMYD5 EED SETD9 KMT2C SETD6 KMT2B DOT1L SETD7 EHMT1 PRDM2 SMYD2 SMYD1 EZH2 KMT5B SMYD4 SMYD3 H4C7 MLL2 H4C9 SETDB1 KMT5C HIST1H4L SETD1B SETD1A SETDB2 SETMAR ASH1L AEBP2 SETBP1 EZH1 SETD2 H3C8 KMT2E MULTIPLE SCLEROSIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260510%WP5540%HOMO SAPIENS Multiple sclerosis mechanism and therapies ITGA4 HEL-S-171mP ITGB1 S1PR5 MS4A1 S1PR1 S1PR3 BTK S1PR4 CREATINE PATHWAY%WIKIPATHWAYS_20260510%WP5190%HOMO SAPIENS Creatine pathway SLC6A8 HEL-S-20 HEL-S-29 THYROID STIMULATING HORMONE TSH SIGNALING%WIKIPATHWAYS_20260510%WP2032%HOMO SAPIENS Thyroid stimulating hormone TSH signaling CREB1 MAP2K3 PLCB1 JAK1 MAPK3 GNAO1 STAT1 IGF1R RPS6 RPS6KB1 BRAF MAPK14 GNB1 GNAS HRAS CDK2 RBL2 PDPK1 PIK3CA SRC RB1 GNAI3 ADCY3 GNAI1 STAT3 MTOR GNG2 CDK4 MAPK1 PDE4D RAF1 MAP2K6 GNA13 PIK3R2 PIK3R1 RPS6KA1 TSHB SCRIB RAP1GAP MYL12B CGA KCNIP3 TSHR APEX1 RAP1A CCND3 CDKN1B CCNE1 MAP2K1 ARYL HYDROCARBON RECEPTOR RESPONSE TO MAIN MEDIATORS PAH AND TCDD%WIKIPATHWAYS_20260510%WP2586%HOMO SAPIENS Aryl hydrocarbon receptor response to main mediators PAH and TCDD EP300 RELA KRAS CYP1B1 CDKN1A CCL1 AHR NQO1 MAPK1 MYC RAF1 AIP CYP1A1 NFKB1 CDC37 CD36 HRAS AHRR CDK2 TNF NRAS LPL PTGS2 RET NF1 PLAGL1 CYP1A2 VEGFA NCOR2 KLF6 SRC NCOA7 CDKN1B NFE2L2 RB1 EGFR GCLC FGF21 MAP2K1 SARS COV 2 B 1 1 7 VARIANT ANTAGONISES INNATE IMMUNE ACTIVATION%WIKIPATHWAYS_20260510%WP5116%HOMO SAPIENS SARS CoV 2 B 1 1 7 variant antagonises innate immune activation IKBKE IRF3 MAVS TRAF3 TRAF6 RIGI TOMM70 IFNB1 TBK1 IL18 SIGNALING%WIKIPATHWAYS_20260510%WP4754%HOMO SAPIENS IL18 signaling CASP8 RELA TNFSF6 NCF1 MAPK9 NCF2 MAPK3 PTEN IRF1 RPS6KB1 ACACB FAS CYCS SP1 CTNNB1 LCK IL37 MYD88 GATA1 NFATC4 HEL-S-102 IRAK1 ELAVL1 IKBKB NFKBIA CHUK TRAF6 MAPK1 NFKB1 IL18 TNF CEBPB PIK3R1 PRKAA1 GSK3B BAX PRKCB MAP3K7 CSN2 PRKCA IL18RAP CASP3 TICAM2 IMP3 GRIN2B TNFRSF1A SLC12A3 IL18R1 PARP1 KLEEFSTRA SYNDROME%WIKIPATHWAYS_20260510%WP5351%HOMO SAPIENS Kleefstra syndrome PAGR1 ASXL1 WDR5 SMARCC1 BAP1 SMARCC2 H3F3B RXRA ACTL6B PAXIP1 KMT2C ACTL6A ARID1A ARID1B SMARCA4 EHMT1 SMARCD1 SMARCD2 SMARCD3 MBD5 NCOA6 NR1I3 DPY30 ASH2L TARGET OF RAPAMYCIN SIGNALING%WIKIPATHWAYS_20260510%WP1471%HOMO SAPIENS Target of rapamycin signaling PRR5 MTOR PRKAA2 DDIT4L RHEB RRAGA FKBP1A ULK1 RPTOR PRKAB2 RPS6KB1 PRKAB1 RAC1 MLST8 CDC42 TSC2 TSC1 DDIT4 PRKAG1 PRKAG2 AKT1S1 PRKAA1 PRKAG3 MAPKAP1 ULK2 RICTOR RRAGB RRAGD HMGCR IDI1 PRKCA EIF4EBP1 GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260510%WP661%HOMO SAPIENS Glucose homeostasis INS NUCLEOTIDE EXCISION REPAIR%WIKIPATHWAYS_20260510%WP4753%HOMO SAPIENS Nucleotide excision repair POLD2 CETN2 XPA RBX1 XPC POLE GTF2H2C_2 RFC3 RFC4 LIG1 RFC1 POLE4 RFC2 GTF2H2 GTF2H3 GTF2H5 CUL4A POLD3 DDB1 ERCC1 POLE3 ERCC2 ERCC5 MNAT1 CUL4B RPA1 DDB2 CDK7 POLE2 RPA3 PCNA CCNH POLD4 TRANSCRIPTION FACTOR REGULATION IN ADIPOGENESIS%WIKIPATHWAYS_20260510%WP3599%HOMO SAPIENS Transcription factor regulation in adipogenesis CEBPD CREB1 INSR SLC2A4 TNF CEBPB IL6 RXRA NR3C1 MAPK8 PPARG LPIN1 IRS1 TWIST1 FOXO1 PCK2 LEP PPARGC1A CEBPA NRF2 ARE REGULATION%WIKIPATHWAYS_20260510%WP4357%HOMO SAPIENS NRF2 ARE regulation INSR EPHB2 CEBPB YES1 FYN RBX1 SLC7A11 AIMP2 HMOX1 MAPK8 GSK3B PIK3CA SRC PRKCA NFE2L2 NQO1 GCLC PGAM5 GCLM MAF KEAP1 LTF DANGER SIGNAL RESPONSE PATHWAY%WIKIPATHWAYS_20260510%WP4478%HOMO SAPIENS LTF danger signal response pathway TNF TLR4 IL6 MYD88 IFNB1 IL1A CXCL8 TREM1 IL1B CD14 IFNA1 TRAF6 MAPK1 IRAK4 HEL110 AGER NFKB1 IRAK1 TARGETED THERAPY IN BREAST CANCER%WIKIPATHWAYS_20260510%WP5496%HOMO SAPIENS Targeted therapy in breast cancer PIK3R3 PIK3R2 PIK3R1 NRAS ERBB4 KRAS MAPK3 PIK3CA PIK3CD EGFR MAPK1 PIK3R4 PIK3C2G RAF1 PIK3C2A AKT3 PIK3C2B ERBB3 PIK3R5 HRAS ERBB2 IL23 INHIBITORS IN INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260510%WP5516%HOMO SAPIENS IL23 inhibitors in inflammatory bowel disease IFNG STAT3 TNF IL23A CSF2 TLR4 IL12B IF2B1 STAT5B RORC IL17F STAT1 IL17A STAT4 TYK2 IL12RB1 TYPE I COLLAGEN SYNTHESIS IN THE CONTEXT OF OSTEOGENESIS IMPERFECTA%WIKIPATHWAYS_20260510%WP4786%HOMO SAPIENS Type I collagen synthesis in the context of osteogenesis imperfecta FZD1 PLOD2 TNFRSF11B MIA3 TNFRSF11A PLOD1 ADAMTS2 TNFSF11 TMEM38B COLGALT1 IFITM5 MBTPS1 CRTAP P3H2 P3H1 COL1A2 BMP1 LOX P4HA1 COL1A1 P4HA2 SP7 PPIB MBTPS2 LRP5 LRP6 WNT1 MITOCHONDRIAL LONG CHAIN FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260510%WP368%HOMO SAPIENS Mitochondrial long chain fatty acid beta oxidation CPT2 EHHADH ACADM ACSL1 FACL4 PECR ACSL3 ACADVL ACSF2 ACADL SLC25A20 ACADS CPT1A FOLATE METABOLISM%WIKIPATHWAYS_20260510%WP176%HOMO SAPIENS Folate metabolism CSF1 RELA SHMT1 PLAT CRP IL2 IFNG CCL2 SCARB1 HEL-S-44 LDLR HBB HBA2 IL4 MTHFS MPO MAT1A MTHFD1 APOB MTHFD2 SERPINA3 SLC46A1 FLAD1 FGA MTRR IZUMO1R F7 SAA4 PLG INSR CBS MTR SLC19A1 HEL-S-78p ALB SAA1 SAA2 FOLR3 FOLR2 FOLR1 HEL-S-51e IL1B F2 NFKB1 DHFR ABCA1 TNF GPX4 IL6 GPX2 GPX1 GPX3 GPX6 NFKB2 CTH INS IL1 SIGNALING%WIKIPATHWAYS_20260510%WP195%HOMO SAPIENS IL1 signaling MAP2K3 NFKBIB RELA PRKCZ REL MAPKAPK2 HEL-S-71 MAPK9 HSPB2-C11orf52 MAPK8 MAP3K2 IL1R1 IL1A PELI1 PLCG1 TAB3 MAPK3 UBE2V1 SQSTM1 IKBKB IL1B NFKBIA MAP3K1 CHUK TRAF6 MAPK1 MAPK14 IKBKG IRAK4 MAP3K14 NFKB1 MAP2K6 ECSIT MAP2K2 PIK3R2 PIK3R1 MYD88 PTPN11 MAP2K4 JUN MAP3K7 IRAK2 IRAK3 MAP3K7IP1 ATF2 MAP2K1 IRAK1 STEROID HORMONE PRECURSOR BIOSYNTHESIS%WIKIPATHWAYS_20260510%WP5277%HOMO SAPIENS Steroid hormone precursor biosynthesis CYP21A2 SRD5A2 AKR1C1 HSD3B2 HSD3B1 CYP11A1 AKR1D1 CYP17A1 PHYSIOLOGICAL AND PATHOLOGICAL HYPERTROPHY OF THE HEART%WIKIPATHWAYS_20260510%WP1528%HOMO SAPIENS Physiological and pathological hypertrophy of the heart CALM1 MAP2K3 STAT3 MAPK11 MAPK8 EDN1 JUN PRKCB PRKCE CTF1 MYEF2 NFATC4 IL6ST CAMK2D MAPK14 MAPK1 RAC1 PPP3CA GATA4 ARHA FOS HIPPOCAMPAL SYNAPTOGENESIS AND NEUROGENESIS%WIKIPATHWAYS_20260510%WP5231%HOMO SAPIENS Hippocampal synaptogenesis and neurogenesis CREB1 BCL2 CALM1 BDNF PRL RPS6KA1 DRD1 NCAM1 NGF HNRNPL PRKCA RPS6KA5 CAMK4 SYT2 NRXN1 NRXN3 MAPK14 MAPK1 NRXN2 CAMK2A CAMKK1 CAMKK2 CCND2 PPARGC1A LDL INFLUENCE ON CD14 AND TLR4%WIKIPATHWAYS_20260510%WP5272%HOMO SAPIENS LDL influence on CD14 and TLR4 CREB1 CCL2 MAPK12 TLR4 RELB MAPK11 IL6 RELA REL IL10 CREB3L3 NFKB2 CREB3L4 IL1B CREB3L2 CD14 CREB3 MAPK14 NFKB1 MAPK13 CREB5 ATF4 CARNOSINE METABOLISM OF GLIAL CELLS%WIKIPATHWAYS_20260510%WP5313%HOMO SAPIENS Carnosine metabolism of glial cells SLC15A2 CARNS1 SLC15A4 VITAMIN D IN INFLAMMATORY DISEASES%WIKIPATHWAYS_20260510%WP4482%HOMO SAPIENS Vitamin D in inflammatory diseases PPP3R1 MED14 MAP2K3 TNF IL6 RXRA RELA NR3C1 NFATC1 IKBKB NFKBIA MAP3K1 CHUK MAPK14 IKBKG SMAD4 PPP3CA NFKB1 MAP2K6 NR1i1 HEROIN METABOLISM%WIKIPATHWAYS_20260510%WP2645%HOMO SAPIENS Heroin metabolism BCHE CES2 CES1 THERMOGENESIS%WIKIPATHWAYS_20260510%WP4321%HOMO SAPIENS Thermogenesis RPS6KA3 CREB1 MAP2K3 MAPK12 PRKAA2 MAPK11 RPS6 RPTOR CNR1 RPS6KB1 RPS6KB2 MAPK14 CPT1A GNAS MLST8 HRAS ACTG1 TSC2 TSC1 PRKACG CPT2 AKT1S1 SOS1 ACSL1 SOS2 FACL4 ADRB3 ACSL3 SMARCD1 SLC25A20 SMARCD2 SMARCD3 FGF21 ATF2 ADCY3 DPF1 ADCY1 ADCY8 DPF3 SMARCE1 GCG ADCY6 SMARCC1 SMARCC2 MTOR ACTL6B RHEB PS1TP5BP1 ACTL6A KRAS ARID1A GRB2 ARID1B PPARG SMARCA4 CREB3L3 FGFR1 CREB3L4 CREB3L2 PRKAB2 CREB3 PRKAB1 ACSL6 CREB5 MAPK13 ACSL5 SIRT6 PRDM16 NRAS LIPE RPS6KA6 RPS6KA2 RPS6KA1 PRKAG1 PRKG1 PRKAG2 FRS2 PRKAG3 CPT1C PRKAA1 ZNF516 PLIN1 MGLL KDM3A KDM3B UCP1 HEL-S-7a SLC25A29 BMP8A BMP8B PNPLA2 KDM1A MAP3K5 ADCY9 PPARGC1A NUCLEAR RECEPTORS%WIKIPATHWAYS_20260510%WP170%HOMO SAPIENS Nuclear receptors NR1B3 THRA NR5A2 ESRRA RARB NR5A1 NR3C1 PPARG RORC NR2F6 RORA NR1C2 NR3A2 PGR NR1H3 NR1C1 NR1i1 RXRA NR2F2 RARA NR2E1 NR1A2 NR2A1 ROR1 NR2C2 RXRB RXRG NR1i2 ESRRB NR1I3 NR1H2 NR2F1 NR1D2 NR0B1 AKT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260510%WP5531%HOMO SAPIENS AKT signaling and ARTD family members PHLPP1 PARP3 MTOR PARP2 PIK3CD RPTOR IKBKG AKT3 MLST8 STK11 PIK3R3 PIK3R2 PIK3R1 TSC2 TSC1 SIRT1 MAPKAP1 RICTOR GSK3B PIK3CA ATM FOXO1 PIK3R4 PIK3C2G PIK3C2A PARP1 PIK3C2B PIK3R5 NEPHROTOXCICITY ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260510%WP5229%HOMO SAPIENS Nephrotoxcicity adverse outcome pathway SLC31A1 SLC22A2 GASTRIC ACID PRODUCTION%WIKIPATHWAYS_20260510%WP2596%HOMO SAPIENS Gastric acid production CBLIF VIP SCT CCK PGA3 PGC PGA5 GAS MUC6 T CELL ANTIGEN RECEPTOR TCR PATHWAY DURING STAPHYLOCOCCUS AUREUS INFECTION%WIKIPATHWAYS_20260510%WP3863%HOMO SAPIENS T cell antigen receptor TCR pathway during Staphylococcus aureus infection ZAP70 CSF2 MAPK9 GRAP2 DAG1 CHP1 IL10 MAP3K8 PLCG1 AHSA1 MAPK3 LCP2 CARD11 BCL10 ICOS CD40LG CD3D IL2 MAP2K2 IFNG CALM1 LCK PTPRC SOS1 NCK1 IL4 JUN PIK3CA LAT CBL ITK NFATC2 CD8A CTLA4 FYN PTPN6 PDCD1 GRB2 CDK4 IKBKB NFKBIA CHUK RRAS IKBKG RAF1 MAP3K14 NFKB1 TNF PAK1 GSK3B MAP3K7 MAP2K1 IL5 FOS PRKCQ TROP2 REGULATORY SIGNALING%WIKIPATHWAYS_20260510%WP5300%HOMO SAPIENS TROP2 regulatory signaling CHEK1 PAK4 ITGB1 CDKN2A CDK4 PTEN STAT1 IGF1R ACVRL1 PSEN2 HEL113 CCND1 TACSTD2 MDK RAC1 ABCC1 IGF2 NFKB1 IGF2R CLDN7 PECAM1 TLN1 CDK2 BCL2 CTNNB1 PIK3R1 NOTCH1 JUN BAX SRC CDKN1B PRKCA CCNE1 RB1 EGFR CLDN1 IGF1 MIRNA REGULATION OF P53 PATHWAY IN PROSTATE CANCER%WIKIPATHWAYS_20260510%WP3982%HOMO SAPIENS miRNA regulation of p53 pathway in prostate cancer EI24 APAF1 SIAH1 SHISA5 TNFRSF10B BBC3 CYS1 TP53AIP1 CASP8 SESN3 ZMAT3 PERP MDM2 PMAIP1 BAX PTEN CASP9 CASP3 ATM DDB2 CHEK2 DISORDERS OF NAD METABOLISM%WIKIPATHWAYS_20260510%WP5506%HOMO SAPIENS Disorders of NAD metabolism BST1 NAXE NAXD NADSYN1 DNAJB1 PRKACA FUSION IN FIBROLAMELLAR LIVER CANCER%WIKIPATHWAYS_20260510%WP5514%HOMO SAPIENS DNAJB1 PRKACA fusion in fibrolamellar liver cancer CREB1 SIK3 SIK1 SIK2 GNAS DNAJB1 HDAC5 CRTC2 HDAC7 EFFECTS OF NITRIC OXIDE%WIKIPATHWAYS_20260510%WP1995%HOMO SAPIENS Effects of nitric oxide MB AOX1 XDH NOS2 HBB HBA2 NON SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260510%WP4255%HOMO SAPIENS Non small cell lung cancer RARB CASP8 JAK3 CDKN1A PLCG2 FOXO3A PLCG1 MAPK3 STAT5B PIK3CD BRAF CCND1 AKT3 CYCS HRAS MAP2K2 RXRA SOS1 SOS2 MET PDPK1 PIK3CA ALK RB1 HEL-S-61 EGFR EML4 CRABP2 CRABP1 TGFA STK4 FHIT EGF STAT3 HGF CDKN2A KRAS GRB2 CDK6 CDK4 ARAF KIF5A MAPK1 RASSF1 RAF1 POLK DDB2 NRAS E2F2 E2F3 BAK1 GADD45B BAD GADD45A GADD45G RET BAX CASP9 PRKCB PRKCA CASP3 RXRB RXRG MAP2K1 ERBB2 COMPLEMENT ACTIVATION%WIKIPATHWAYS_20260510%WP545%HOMO SAPIENS Complement activation C1R CFP C4B_2 C2 C6 C7 C9 C1QA MASP2 MASP1 CD55 CFD HEL-S-62p C1QB C8A C1S C4A C1QC C8G IL4 SIGNALING%WIKIPATHWAYS_20260510%WP395%HOMO SAPIENS IL4 signaling INPP5D EP300 STAT3 GAB2 MAPK11 PTPN6 IL2RG RELA JAK3 GRB2 MAPK3 JAK1 IKBKB STAT5B PIK3CD NFKBIA STAT1 CHUK RPS6KB1 MAPK1 MAPK14 SOCS1 NFKB1 TYK2 CEBPA PIK3R2 CEBPB PIK3R1 SOCS3 BAD PTPN11 SOS1 IL4 PIK3CA SHC1 IRS1 ATF2 CBL FLNA SOCS5 FOS FES TAR SYNDROME%WIKIPATHWAYS_20260510%WP5362%HOMO SAPIENS TAR syndrome POLR3GL FLT3 POLR3C HLA-G POLR3F POLR3G CD3D CXCR4 IFNG LCK FARP2 MET HDAC2 HLA-A EGFR ANKRD35 EIF4A3 GPR89B STAT3 CCAR2 ITGB1 SLK SUMO2 MAGOH SLC34A3 NUDT17 HEL-S-76p HLA-B HLA-C HFE2 HLA-F HLA-E RBCK1 CFTR SLC22A4 PEX11B FURIN TXN AKAP10 CLCN3 BCL2L13 TNFRSF14 ZFHX3 PEX19 NHERF1 UBE2I PYM1 PDZK1IP1 NFKB1 MITD1 DDIT4 SIRT1 CD160 LAMTOR1 HAMP SYNTHESIS OF CERAMIDES AND 1 DEOXYCERAMIDES%WIKIPATHWAYS_20260510%WP5194%HOMO SAPIENS Synthesis of ceramides and 1 deoxyceramides B4GALT1 CERK SGMS1 SPHK1 SGMS2 DGAT1 UGT8 UGCG B3GNT5 B4GALNT1 KDSR A4GALT A3GALT2 CERS1 tmp_locus_29 CERS2 SPTLC1 CERS3 CERS5 CERS6 GENES TARGETED BY MIRNAS IN ADIPOCYTES%WIKIPATHWAYS_20260510%WP1992%HOMO SAPIENS Genes targeted by miRNAs in adipocytes HAND2 KCNJ2 HCN2 GJA1 ERG TMSB4X IGF1 HCN4 KCNE1 ANDROGEN RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP138%HOMO SAPIENS Androgen receptor signaling NCOR1 CREB1 ZNF318 EP300 FKBP4 RNF6 RNF4 HEL-S-67p RELA BAG1 PATZ1 LIMK2 NR0B2 STUB1 SMIM40 RLN1 RAD9A PTEN CREBBP NCOA1 CCND1 SMAD4 ARHA SP1 CTNNB1 JUN SRC HDAC1 RB1 EGFR FOXO1 ETV5 KAT5 FLNA PAK6 HEL-S-99n SMARCE1 STAT3 BRCA1 SIN3A MDM2 RUNX2 CARM1 PSMC3IP UBE2I RAC1 ROCK1 ROCK2 RHOB CDC42 PIK3R2 PIK3R1 SIRT1 GSK3B NCOR2 TGFB1I1 FHL2 UBE3A CCNE1 KDM1A EFCAB6 SUMO1 RAN ZMIZ1 HEL32 NR2C2 KAT7 TGIF1 PIAS2 PIAS1 TLE5 KAT2B MTHFR DEFICIENCY%WIKIPATHWAYS_20260510%WP4288%HOMO SAPIENS MTHFR deficiency PEMT CHKA EHMT1 HEL-S-61p MARS1 ASMT ALDH7A1 CASP9 CASP3 GRIN1 CHDH DNMT3B CYCS FLT3 P GLN640SERFSTER8 SIGNALING%WIKIPATHWAYS_20260510%WP5431%HOMO SAPIENS FLT3 p Gln640SerfsTer8 signaling FLT3 STAT3 CCR5 CCR6 DEVELOPMENT OF PULMONARY DENDRITIC CELLS AND MACROPHAGE SUBSETS%WIKIPATHWAYS_20260510%WP3892%HOMO SAPIENS Development of pulmonary dendritic cells and macrophage subsets STAT3 CSF2 CSF1 IRF4 TCF4 RUNX2 BATF3 SPI1 FLT3LG IKZF1 TPO ID2 IRF8 CYTOKINES AND INFLAMMATORY RESPONSE%WIKIPATHWAYS_20260510%WP530%HOMO SAPIENS Cytokines and inflammatory response CSF3 CSF2 CSF1 IL7 PDGFA IL13 IL12B IL10 IL1A IL15 TGFB1 IL1B IL11 CXCL1 HLA-DRA IL2 CXCL2 IFNG TNF IL3 IL6 IFNB1 IL4 HLA-DRB1 IL5 11P11 2 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260510%WP5348%HOMO SAPIENS 11p11 2 copy number variation syndrome REST ITGB1 SHH ITGA4 TIMP1 NRXN1 HLA-DRA LGALS3BP IGSF8 CD151 CD82 SPPL2C PRDM11 ACCS PHF21A ALKBH3 SDCBP C11orf96 HLA-DMB CD19 MS4A1 ALX4 TP53I11 LARGE2 HLA-DMA PEX16 CHST6 IZUMO1 SLC35C1 SYT13 MAPK8IP1 EXT1 VANGL1 EXT2 FREY1 SLC25A17 LEF1 B4GAT1 B3GNT7 PEX3 TSPAN18 CHST1 HBEGF CD63 ITGA6 B4GALT4 GLI3 CRY2 TYPE I INTERFERON INDUCTION AND SIGNALING DURING SARS COV 2 INFECTION%WIKIPATHWAYS_20260510%WP4868%HOMO SAPIENS Type I interferon induction and signaling during SARS CoV 2 infection IRF9 IKBKE IRF3 TLR4 IRF7 TLR7 TLR3 RIGI JAK1 STAT1 TRAF6 IRAK4 TYK2 IFNAR2 ACE2 MAVS TRAF3 IFNAR1 MYD88 STAT2 TMPRSS2 EIF2AK2 OAS1 OAS2 IFIH1 TREML4 TBK1 TLR9 ROS IN COVID 19 ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260510%WP5258%HOMO SAPIENS ROS in COVID 19 endothelial dysfunction TNF ACE2 IFNA1 IFNAR1 TNFRSF1A NFKB1 BRAIN DERIVED NEUROTROPHIC FACTOR BDNF SIGNALING%WIKIPATHWAYS_20260510%WP2380%HOMO SAPIENS Brain derived neurotrophic factor BDNF signaling CREB1 RASGRF1 TIAM1 MAP2K5 PRKAA2 RELA MAPK9 MAPK8 PLCG1 MAPK3 CNR1 MAPK14 YBX1 PPP2CA CTNNB1 JUN HEL-S-15 NFATC4 MEF2C IKBKB NFKBIA MAP3K1 CHUK TRAF6 MAPK1 IKBKG RAF1 NFKB1 CDC42 GRIA2 NGF RAP1A GRIN2B IRS1 GRIN1 ADAM17 RPS6KA3 SH2B2 GRIP1 NCF1 NCF2 FOXO3A STAT5B VAV3 STAT1 RPS6 RPS6KB1 ACACB HRAS MAP2K2 KSR1 TSC2 NCK2 NCK1 PDPK1 SHC1 SRC SORT1 SHC4 SHC3 CAMK2A NTRK1 NGFR EIF4EBP1 NTRK2 CRTC1 CDH2 STAT3 SIRPA MAPK10 CDKL5 FYN MTOR CSNK2A1 FRS3 APC DOK5 KCNN2 RANBP9 GRIA3 NCAM1 EIF2S2 EEF2 GRB2 EIF2S1 CDK5 VAV2 MAP3K2 DOCK3 PTPRF SYN1 SQSTM1 KCNA3 MAPK7 NTF3 RPS6KA5 IGF2BP1 PTK2B SH2B1 CAMK4 LINGO1 KIDINS220 NTRK3 CAMK1 ARHG RAC1 MARCKS CDK5R1 SHC2 PIK3R2 BDNF PIK3R1 GABRB3 RPS6KA1 FRS2 PRKAA1 BAD PTPN11 GSK3B EIF4E CASP3 MAP2K1 CYFIP1 UREA CYCLE AND METABOLISM OF AMINO GROUPS%WIKIPATHWAYS_20260510%WP497%HOMO SAPIENS Urea cycle and metabolism of amino groups ASL NAGS ALDH18A1 HEL-S-5 HEL-S-20 HEL-S-29 GLUD1 ARG2 OTC ARG1 ASS1 SRM SMS NEPHROGENESIS%WIKIPATHWAYS_20260510%WP5052%HOMO SAPIENS Nephrogenesis OSR1 FGF8 GREB1L TCF21 PAX2 MEIS1 NOTCH2 WNT9B SIX2 ALDH1A2 RSPO3 RSPO1 FOXD1 WNT4 FGF20 WNT3A BMP7 EIF5A REGULATION IN RESPONSE TO INHIBITION OF THE NUCLEAR EXPORT SYSTEM%WIKIPATHWAYS_20260510%WP3302%HOMO SAPIENS eIF5A regulation in response to inhibition of the nuclear export system IGF2BP1 EIF5A XPO4 KISSPEPTIN KISSPEPTIN RECEPTOR SYSTEM IN THE OVARY%WIKIPATHWAYS_20260510%WP4871%HOMO SAPIENS Kisspeptin kisspeptin receptor system in the ovary FSHR KRAS CYP11A1 PLCB1 MAPK3 PIK3CD HSD3B1 MAPK1 RAF1 PLCB2 NFKB1 MMP9 HRAS STAR MAP2K2 NRAS PLCB4 ARRB2 KISS1R KISS1 GDF9 PRKCH PLCB3 PIK3CA PRKCB PRKCE PRKCA MAP2K1 BMP15 AMH PRKCQ CONGENITAL GENERALIZED LIPODYSTROPHY%WIKIPATHWAYS_20260510%WP5101%HOMO SAPIENS Congenital generalized lipodystrophy FYN DGAT1 HIF1A GRB2 DGAT2 CAVIN1 PIK3CA ITGB4 BSCL2 HMFN0839 LPIN2 LPIN3 LPIN1 IRS1 INS SELECTIVE EXPRESSION OF CHEMOKINE RECEPTORS DURING T CELL POLARIZATION%WIKIPATHWAYS_20260510%WP4494%HOMO SAPIENS Selective expression of chemokine receptors during T cell polarization CCL3 CCR1 IFNG CSF2 CCR7 CCR4 CCR2 IL12B IL4 IL12A TGFB1 CCR5 CD40LG IFNGR2 CXCR4 IL2 IL18R1 IFNGR1 IL5 IL12RB1 CXCR3 CCL4 CCR3 UROTENSIN II MEDIATED SIGNALING%WIKIPATHWAYS_20260510%WP5158%HOMO SAPIENS Urotensin II mediated signaling EP300 RELA HMOX1 GSK3A NCF1 MAPK9 NCF2 MAPK8 NCF4 MAPK3 PTEN CREBBP TGFB1 CYBB CYBA MAPK14 SMAD2 CDC2 ARHA HDAC5 CDK2 BCL2 CTNNB1 VCAM1 ESPL1 PCNA ALOX5 DDIT3 EGFR CAMK2A STAT3 IRF3 PLN IKBKB IL1B CHUK MAPK1 AGTR1 MMP2 NFKB1 MMP9 ABCA1 TNF IL6 UTS2R PTPN11 GSK3B COL1A1 BAX COL3A1 CASP9 COL2A1 CCNE1 UTS2 CASP3 NPPB AIFM2 NPPA TRPC4 ACTA2 HSPA2 NOX4 PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20260510%WP98%HOMO SAPIENS Prostaglandin synthesis and regulation HSD11B1 HSD11B2 EDNRA PRL EDNRB PTGFRN HEL-S-7 S100A10 ANXA1 PTGIS ANXA2 ANXA3 ANXA4 AKR1C2 SCGB1A1 CYP11A1 S100A6 PPARG PTGES AKR1C1 PPARGC1B PTGDR PTGER4 HPGD PTGS2 SOX9 PTGFR ANXA6 PTGS1 PTGIR PTGER1 PTGER2 EDN1 PTGER3 TBXA2R PPARGC1A AKR1B1 EVOLOCUMAB MECHANISM TO REDUCE LDL CHOLESTEROL%WIKIPATHWAYS_20260510%WP3408%HOMO SAPIENS Evolocumab mechanism to reduce LDL cholesterol PCSK9 LDLR AMPK REGULATION OF MAMMARY MILK PROTEIN SYNTHESIS%WIKIPATHWAYS_20260510%WP5492%HOMO SAPIENS AMPK regulation of mammary milk protein synthesis TSC2 MTOR PRKAA2 PRKAG1 PRKAG2 EEF2K PRKAA1 PRKAG3 EEF2 EIF4A2 CSN3 EIF4E CSN1S1 EIF4G1 CSN2 PRKAB2 RPTOR RPS6KB1 PRKAB1 MLST8 DISORDERS OF GALACTOSE METABOLISM %WIKIPATHWAYS_20260510%WP5173%HOMO SAPIENS Disorders of galactose metabolism SLC2A2 SLC5A1 GYS2 HEL-S-19 GYS1 PYGL GYG1 AKR1B1 GLYCINE METABOLISM%WIKIPATHWAYS_20260510%WP1495%HOMO SAPIENS Glycine metabolism HEL-S-51e SHMT1 DNA IR DAMAGE AND CELLULAR RESPONSE VIA ATR%WIKIPATHWAYS_20260510%WP4016%HOMO SAPIENS DNA IR damage and cellular response via ATR CHEK1 MRE11A NBN BRCA2 BCL6 XPA CLK2 RAD9A PRKDC DCLRE1A SMARCAL1 MDC1 FEN1 UBE2D3 CEP164 PLK1 FOXM1 RNF8 HERC2 CDC2 UIMC1 TOPBP1 SP1 RECQL HUS1 CDK2 FANCD2 ATR EEF1E1 MCPH1 ABRAXAS1 SMC1A BRCC3 PPM1D BRIP1 RBBP8 USP1 FANCA CLSPN TP53BP1 ATRIP POLN XRCC5 SHFM1 PALB2 MCM2 TDP1 RAD17 PCNA RAD1 RMI1 TOP3A CDC45 PML SMARCC2 BRCA1 MSH2 MDM2 RECQL4 WRN BARD1 IKBKG RPA1 RFWD3 H2AX RAD52 TRIM28 ATM PARP1 RAD50 CHEK2 RAD51 CANCER PATHWAYS%WIKIPATHWAYS_20260510%WP5434%HOMO SAPIENS Cancer pathways RELA MAPK9 MAPK8 PLCG2 JAG2 PLCG1 DLL3 MAPK3 DLL4 TGFB1 JUP BRAF IL2 ARHA SP1 BCL2 CTNNB1 PLCB4 JUN PIK3CA VEGFC IFNA1 FH IL13RA1 CDKN1A IL15RA FLT3 FLT4 IL15 PTEN PIK3CD NR1C2 IGF1R NR3A2 CCND1 CXCR4 MYC AKT3 HRAS IL6R PDGFRA MAP2K2 IL3 AXIN2 CXCL12 IL2RB KIT CTBP1 RARA SOS1 FRAT1 SOS2 DVL1 MET DVL2 CSF1R DVL3 TCF7L2 PIM1 PIM2 LEF1 LRP5 AXIN1 EGFR FOXO1 LRP6 WNT1 RUNX1T1 NTRK1 ZBTB16 STAT3 PML MTOR APC MDM2 KRAS GRB2 FGFR4 FGFR3 FGFR2 FGFR1 CALML6 ARAF CALML3 CALML4 RASSF1 RAC1 POLK MMP2 DAPK2 DDB2 PIK3R3 PIK3R2 PIK3R1 NRAS E2F2 E2F3 BAK1 GADD45B BAD GADD45A GADD45G BAX CCND3 CDKN1B CCNE1 CCND2 RAD51 EP300 SKP2 BRCA2 SKP1 RBX1 CCNE2 SMAD2 SMAD4 CDK2 CCNA2 HDAC2 HDAC1 LAMC1 CDKN2B MSH6 CCDC6 VHL PTGS2 RET ERBB2 APAF1 BBC3 CASP8 BCL2L11 TNFSF6 FADD BCL2L1 IL5RA IL13 CSF2RB PLCB1 JAK1 CREBBP STAT5B STAT1 IL6ST RPS6KB1 RPS6KB2 STAT4 IL12RB1 EPO EPOR KITLG IL3RA RXRA CRKL CRK TGFA CBL EGF MAPK10 ITGB1 LAMA5 PDGFA SHH FZD1 HEL-S-21 BMP4 GNGT2 KEAP1 TGFBR2 GNG10 BIRC2 NOTCH2 NOTCH1 TERT VEGFA NFKB2 NFE2L2 RXRB RXRG RARB IL2RG JAK3 IGF2 F2R ALK EML4 IGF1 IL7 WNT2B FZD10 WNT5B WNT9B WNT9A WNT16 BDKRB2 BDKRB1 RAC3 APC2 WNT8A WNT8B WNT3 WNT10B F2 WNT10A FZD3 FZD2 FZD5 ARHGEF1 FZD4 WNT3A WNT7B ROCK1 FZD7 ROCK2 FZD9 VEGFB WNT7A FZD8 GNA13 EGLN1 EGLN3 EGLN2 ELOC BIRC7 FLT3LG IFNGR1 TGFBR1 RUNX1 IFNG IL23A HIF1A IL4 IL2RA ITGA6 ITGAV NOS2 COL4A2 BIRC5 SPI1 BIRC3 HEL-S-125m RPS6KA5 ITGA2 CEBPA CTNNA1 EVI1 PMAIP1 EDN1 GSTM2 GSTM1 GSTT2 IFNGR2 GSTA5 IL5 EDNRA EDNRB MGST1 IL12B HES1 IL12A NCOA1 NQO1 PRKACG BMP2 WNT4 TFG KPG_010 RB1 BCR CTBP2 GSTM4 GSTM3 IF1AA9 GLI3 GSTM5 HEY2 APPL1 PAX8 CSF3R ITGA2B IFNA13 IFNA14 IFNA16 TPM3 IFNA17 MSH3 CDKN2A IFNA10 NOTCH3 PTCH1 MAX KNG1 TPR PPARG IFNA21 CDK6 HSP90AB1 SMO NKX3-1 CDK4 PLEKHG5 TRAF1 IKBKB TRAF4 CCDC42 NFKBIA HHIP CHUK FRAT2 MGST3 TRAF6 MGST2 LPAR2 MAPK1 IKBKG LPAR3 LPAR4 RAF1 GSTT2B NFKB1 IFNA4 IFNA7 IFNA6 IFNA2 IFNA8 IFNAR2 SUFU KIF7 TRAF2 CTNNA3 CTNNA2 TRAF5 ARNT2 VEGFD IFNAR1 GSTA4 GSTA3 F2RL3 RALBP1 COL4A1 COL4A4 COL4A3 COL4A6 STAT2 COL4A5 CSF2RA RASGRP4 PRKCB PLD2 RASGRP3 PRKCA PTCH2 IL7R LAMC2 CKS1B ARHGEF11 ARHGEF12 ADCY9 DCC MMP3 HEL-S-22 RALA RALB LAMA1 LAMA4 LAMA3 HES5 LAMB3 LAMB2 LAMB4 LAMB1 HMOX1 GNG12 GNG11 GNG13 GNB2 FAS GNB1 GNAS CYCS GNB4 GNB3 GNB5 GNGT1 PLCB3 CAMK2D CAMK2A GNAI3 ADCY3 ADCY1 ADCY8 GNAI1 ADCY6 GNG3 TCF7L1 GNG2 HGF GNG5 MSH2 GNG4 GNG7 GNA11 KLK3 GNG8 CAMK2G AGTR1 PLCB2 IL6 TRAF3 PTGER4 TXNRD3 PTGER1 TXNRD2 PTGER2 GSK3B PTGER3 CXCL8 LPAR1 CASP9 CASP3 MAP2K1 FOS WNT SIGNALING%WIKIPATHWAYS_20260510%WP428%HOMO SAPIENS Wnt signaling MAPK9 MAPK8 FOSL1 ARHA CTNNB1 PLCB4 DKK1 SFRP1 JUN WNT4 NFATC3 NFATC4 CTBP2 WNT2B FZD10 WNT5B WNT16 SFRP4 WNT3 WNT10B WNT10A FRAT2 FZD3 FZD2 FZD5 WNT3A WNT7B FZD7 ROCK2 FZD9 WNT7A FZD8 PRKCB MAP3K7 PRKCA SOX17 CER1 CSNK2A3 CSNK2A2 CTNNBIP1 DKK2 DAAM1 DAAM2 SFRP5 PLCB1 CSNK2B PORCN PPP3R2 INVS CHD8 SOST KREMEN1 SENP2 CCND1 PRICKLE2 CXXC4 MYC NKD1 PPP3CA NKD2 WIF1 GPC4 NOTUM CTBP1 NLK FRAT1 NFATC1 DVL1 DVL2 VANGL1 DVL3 PLCB3 TCF7L2 LEF1 RYK AXIN1 LRP5 CSNK1E CAMK2D ROR1 ROR2 LRP6 WNT1 CAMK2A CSNK1A1 NFATC2 TCF7L1 CSNK2A1 APC FZD1 CAMK2G PPP3CC RAC1 PLCB2 DKK4 PPP3R1 GSK3B CCND3 CCND2 NICOTINE EFFECT ON DOPAMINERGIC NEURONS%WIKIPATHWAYS_20260510%WP1602%HOMO SAPIENS Nicotine effect on dopaminergic neurons KCNK9 CHRNA5 GNAI1 DDC CHRNA6 TH PPP1R1B SLC18A2 GNG2 DRD4 KCNK3 DRD2 DRD3 CHRNB2 CDK5 GNB1 CHRNA3 TGF BETA RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP560%HOMO SAPIENS TGF beta receptor signaling EP300 MAPK9 JAK1 MAPK3 CREBBP TGFB1 STAT1 SMAD2 SMAD4 HRAS TGFBR1 LEFTY1 IFNG CTNNB1 ZFYVE9 ITGB6 SMAD1 NOG SMAD9 FOXH1 RUNX3 ENG FST LTBP1 SKIL DKFZp781O1323 LIF LEFTY2 JUN SMAD6 SKI BAMBI LEF1 WNT1 EGF STAT3 TGFBR3 INHBA RUNX2 BMP4 FKBP1A THBS1 NFKB1 TNF TGFBR2 ZNF423 SPP1 ZEB2 TGIF1 FOS REGULATION OF WNT B CATENIN SIGNALING BY SMALL MOLECULE COMPOUNDS%WIKIPATHWAYS_20260510%WP3664%HOMO SAPIENS Regulation of Wnt B catenin signaling by small molecule compounds CTNNB1 TCF4 APC FZD1 SFRP4 GSK3B DVL2 TNKS LEF1 MBOAT1 AXIN1 DKK3 WNT1 FZD7 CSNK1A1 FZD8 MITOCHONDRIAL FATTY ACID OXIDATION DISORDERS%WIKIPATHWAYS_20260510%WP5123%HOMO SAPIENS Mitochondrial fatty acid oxidation disorders CPT2 EHHADH ACADM ACSL1 FACL4 PECR ACSL3 ACADVL SLC22A5 ACSF2 HADHB ACADL SLC25A20 ACADS CPT1A ARYLAMINE METABOLISM%WIKIPATHWAYS_20260510%WP694%HOMO SAPIENS Arylamine metabolism CYP1A2 SULT1A1 NAT2 UGT1A9 SULT1A2 UGT1A4 STEROIDOGENIC PATHWAY%WIKIPATHWAYS_20260510%WP4463%HOMO SAPIENS Steroidogenic pathway HSD17B1 HSD3B1 CYP11A1 STAR CYP17A1 PLEURAL MESOTHELIOMA%WIKIPATHWAYS_20260510%WP5087%HOMO SAPIENS Pleural mesothelioma CREB1 SLC3A2 YAP1 EIF4B MAP2K3 CTHRC1 CSF2 ANGPT4 CSF1 AMOT MOBKL1A MAP2K5 PRKAA2 CSNK1A1L MAPK9 MAPK8 MAPK3 TGFB1 MAPK14 MDK IGF2 FOSL1 FGF2 SP1 BCL2 CTNNB1 ACTG1 FGF7 FGF8 PLCB4 FGF9 JUN PIK3CA FGF20 VEGFC FGF23 FGF22 FGF21 RASSF7 IGF1 FGF14 FGF18 CSF3 FGF13 FGF12 FGF10 WNT2B FZD10 FGF8A WNT5B PS1TP5BP1 WNT16 SFRP4 ITGA1 FGF7B WNT3 WNT10B WNT10A FZD3 FGF7A FZD2 FZD5 WNT3A WNT7B FZD7 FZD9 FGF6B VEGFB WNT7A FZD8 FABP4 FGF5C SETD2 RNF2 SLC7A5 CDKN1A IL10 FLT1 FLT3 ITGA4 FLT4 PTEN FLT3LG PIK3CD ULK1 IGF1R RPTOR DEPTOR CCND1 MYC AKT3 KDR MLST8 CCL5 HRAS CCL4 WWTR1 PDGFRA MAP2K2 CCL2 ANGPT2 TSC2 TSC1 ANGPT1 TTI1 HIF1A CXCL12 AKT1S1 KIT CTBP1 ULK2 FRAT1 SOS1 DVL1 MET EPHA2 DVL2 CSF1R DVL3 RB1CC1 SHC1 TCF7L2 SRC RYK LEF1 AXIN1 LRP5 CSNK1E EGFR ITGB3 ROR1 FOXO1 ROR2 ITGA6 LRP6 WNT1 ITGAV NTRK1 NGFR NTRK2 CSNK1A1 INSR CDH2 MTOR CSNK2A1 APC BRCA1 RHEB MDM2 GRB2 FGFR4 COL4A2 FGFR3 FGFR2 CD44 FGFR1 IL1B MAPK7 NTF3 RPS6KA5 PRKAB2 KIF23 PRKAB1 RASSF1 CDH17 MMP2 DKK4 ITGA2 MMP9 SELE CTNNA1 BDNF MAP3K10 PAK1 PRKAG1 PRKAG2 BAK1 PRKAG3 BAX ITGB4 CCND3 CCNE1 ATM CCND2 ACTA2 CDH11 MAPKAPK2 MAD1L1 EIF4G1 FOXM1 CDK7 CDK2 DKK1 SFRP1 WNT4 CTBP2 LAMC1 ATF2 RBBP4 SETD5 SUZ12 MAP3K11 HMGB1 EED CDKN2A KMT2C MAX MEF2D CDK4 EZH2 MAP3K1 FRAT2 BARD1 SETDB1 CXCL1 MAPK1 RAF1 CXCL5 NFKB1 MAP2K6 CTNNA3 TRAF2 CTNNA2 CTGF VEGFD COL4A1 COL4A4 COL4A3 COL4A6 NGF COL4A5 LAMC2 MMP3 INS LAMA1 RPS6KA3 LAMA4 MCL1 LAMA3 ASXL1 WDR5 BAP1 LAMB3 BBC3 LAMB2 LAMB1 SOX17 CER1 CSNK2A3 CSNK2A2 DKK2 SFRP5 CSNK2B JAK1 PORCN STAT1 CHD8 RPS6 SOST KREMEN1 RPS6KB1 SENP2 RPS6KB2 CXXC4 AGER WIF1 CYCS NOTUM KITLG AREG HEL-S-1 TEAD4 MAP2K4 BTC DDIT3 HBEGF SPARC TGFA RASSF2 RASSF3 RASSF4 EIF4EBP1 RASSF6 PAK6 LGALS9 BTRC PAK4 HCFC1 EGF ATF3 MAPK10 IDO1 ITGB1 TCF7L1 PDGFD LAMA5 PDGFC HGF PDGFA STK38L PHC1 LIMD1 BMI1 FZD1 PRSS23 TEAD2 GABPA MAP3K2 TEAD3 MAP4K1 MAP4K2 MINK1 CIT MMP14 TNNT1 CD47 PIGF VGLL4 NTF4 MAP4K3 IL34 MAD2L1 WWC1 CDH9 ACTG2 CDH8 CDH6 YY1 CDH4 MAP3K6 HMGN1 TNIK DSC3 IL6 EFNA5 RPS6KA1 AJUBA EFNA4 BAG2 CDH24 NLRP3 EFNA1 PRKAA1 MOB1A EFNA3 TERT LIN28B EFNA2 MDM4 GSK3B NF2 VEGFA OGT MCU HEL-S-31 PRB1 PRB2 LATS1 ACTA1 MAP3K5 LATS2 CDH10 CDH12 MAP2K1 CDH15 CDH16 CDH18 PPARGC1A CDH19 UHRF1 OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20260510%WP623%HOMO SAPIENS Oxidative phosphorylation NDUFA11 ATP5G1 COXFA4L2 HEL-S-271 ATP6AP2 NDUFC2 NDUFC1 NDUFS8 NDUFS6 NDUFS5 NDUFS4 NDUFS3 NDUFS1 ND3 ND2 ND5 ND4 ND6 NDUFB8 NDUFB7 NDUFB10 NDUFB6 NDUFB5 NDUFB4 ATP6 NDUFB2 ATP5MC2 ATP5MC3 ATP5J NDUFB1 ATP5H HEL-S-123m NDUFV3 NDUFV2 ATP5MG ATP5MF ATP5ME NDUFA9 DMAC2L NDUFA7 NDUFA6 NDUFA5 ATP5PB NDUFA3 NDUFA2 ND4L ATP5F1D ATP5F1E NDUFAB1 ATP5PO NDUFB9 ND1 NDUFA10 COXFA4 WNT BETA CATENIN SIGNALING INHIBITORS IN CURRENT AND PAST CLINICAL TRIALS%WIKIPATHWAYS_20260510%WP5442%HOMO SAPIENS Wnt Beta catenin signaling inhibitors in current and past clinical trials PORCN CREBBP CTNNB1 LRP5 LRP6 METAPATHWAY BIOTRANSFORMATION PHASE I AND II%WIKIPATHWAYS_20260510%WP702%HOMO SAPIENS Metapathway biotransformation Phase I and II CYP21A2 AKR1C2 MGST1 CYP1B1 CYP11A1 UGT1A4 UGT1A3 UGT1A7 UGT1A1 CYP4F2 CYP4F12 TPMT HEL-S-75 GSTM4 HS6ST1 GSTM3 HS6ST2 HS6ST3 GSTM5 CYP4Z1 NDST3 HEL-S-166mP UGT2B11 UGT2B15 UGT2B17 SULT2B1 CYP2U1 SULT6B1 NNMT HS3ST3A1 CYP4F22 CYP2C18 CYP2B6 CYP4X1 CYP27B1 CHST11 CHST12 CYP24A1 CHST10 CYP17A1 CHST13 CHST14 SULT1A4 NAA50 CYP2J2 GATF-C GLYATL2 MGST3 HEL-S-165mP MGST2 EPHX1 CYP4F3 CYP4F11 CYP4F8 GSTT2B CYP26A1 SULT1B1 CYP27C1 AKR1B10 NAT8 CYP2S1 NAT9 NAA40 NAT10 UGT1A10 NAT14 LOC51064 GPX4 HS2ST1 SULT1C3 GSTA4 SULT1C2 GSTA3 CYP26B1 CYP4V2 CYP3A4 HYAL3 CYP2C19 CYP2R1 UGT2A2 CYP2C9 UGT2A1 CYP2C8 GAL3ST3 CYP1A2 GAL3ST4 SULT1C4 CHST8 HS3ST3B1 CHST9 CHST7 CYP3A43 KCNAB1 KCNAB3 INMT CYP2A7 CYP26C1 HEL-S-22 UGT2B4 CHST4 NAT8L CHST5 UGT2B7 CHST3 HEL-S-75p NAA20 UGT2B28 SULT1E1 CYP2A13 UGT1A5 CYP2F1 GAL3ST2 CYP4B1 HS3ST5 HS3ST6 FMO4 HS3ST4 FMO5 HS3ST1 HS3ST2 GSTZ1 CYP2W1 CYP20A1 CYP7A1 CYP8B1 UGT1A9 CHST6 AKR1D1 AKR1C4 BAAT CYP7B1 CYP27A1 EPHX2 SULT1A1 CHST1 NAT2 SULT1A2 CYP3A7 HEL-S-21 CYP46A1 AKR1C1 CYP11B2 CYP2A6 CYP1A1 CYP2E1 GPX2 GPX3 HEL-S-64p GSTM2 GSTM1 GSTT2 HEL-75 SULT2A1 GSTA5 AKR1B1 CYP51A1 GPCRS CLASS C METABOTROPIC GLUTAMATE PHEROMONE%WIKIPATHWAYS_20260510%WP501%HOMO SAPIENS GPCRs class C metabotropic glutamate pheromone GRM2 GABBR2 GABBR1 CASR GRM3 GPRC5A GRM4 GRM6 GRM8 GPRC5D GPRC5C NEURAL CREST CELL MIGRATION IN CANCER%WIKIPATHWAYS_20260510%WP4565%HOMO SAPIENS Neural crest cell migration in cancer ARF1 EPHB2 PAK4 EPHB1 STAT3 TRIO EPHB4 EPHB3 TIAM1 CDH11 F2RL2 PIK3CD KIDINS220 RAC1 AKT3 MMP2 MMP9 ARHA PIK3R3 BDNF PAK1 JUN PIK3CA SORT1 TWIST1 PIK3R4 NGFR PIK3R5 NTRK2 FOS EPHB6 PAK6 PATHOGENIC ESCHERICHIA COLI INFECTION%WIKIPATHWAYS_20260510%WP2272%HOMO SAPIENS Pathogenic Escherichia coli infection TLR4 ITGB1 WASL FYN PS1TP5BP1 ARPC1B ROCK1 ROCK2 WAS ARHA TUBAL3 LY96 TUBB8 CDC42 TUBA3E ACTG1 TUBA1C CTNNB1 TUBB6 TUBA1B TUBA1A TUBB1 TUBB ARPC4 HEL-68 TUBB4B YWHAQ TUBB4A TUBA4A NCK2 TUBB2A NCK1 KRT18 YWHAZ ARPC2 EZR ARPC3 TUBA2 NCL HCLS1 PRKCA ARHGEF2 TLR5 CD14 TUBA8 CLDN1 ARPC5 CANONICAL AND NON CANONICAL NOTCH SIGNALING%WIKIPATHWAYS_20260510%WP3845%HOMO SAPIENS Canonical and non canonical Notch signaling NOTCH2 NOTCH3 NOTCH1 JAG2 DLL3 HES1 DLL4 LEF1 CHUK RRAS MAML2 PSEN2 ADAM10 PSEN1 RBPJ DLK2 MFAP1 DNER MFAP2 MAML1 MAML3 RIBOFLAVIN AND COQ DISORDERS%WIKIPATHWAYS_20260510%WP5037%HOMO SAPIENS Riboflavin and CoQ disorders SLC52A2 ETFDH SLC52A1 PDSS1 ETFA COQ8A COQ9 APTX COQ7 COQ6 FLAD1 COQ2 DNA DAMAGE RESPONSE ONLY ATM DEPENDENT %WIKIPATHWAYS_20260510%WP710%HOMO SAPIENS DNA damage response only ATM dependent BBC3 BCL6 BCL2L11 TNFSF6 MAPK9 MAPK8 CDKN1A FOXO3A PTEN TGFB1 PIK3CD CCND1 PCK2 G6PC1 MYC SMAD4 AKT3 FOSL1 ARHA HRAS BCL2 CTNNB1 RBL2 LDLR FRAT1 SOS1 SOS2 DVL1 DVL2 JUN PIK3CA DVL3 WNT4 SHC1 TCF7L2 LEF1 AXIN1 WNT1 INSR MAPK10 TCF7L1 WNT2B HMGB1 APC WNT5B CDKN2A MDM2 PPP2R5E KRAS PPP2R5C WNT16 GRB2 MLKL BIK RAC3 CCNG2 TP73 WNT3 WNT10B WNT10A MAP3K1 MAPK1 WNT3A RAC1 WNT7B NFKB1 WNT7A CDC42 PIK3R3 PIK3R2 PIK3R1 NRAS BAK1 BAD PMAIP1 GSK3B BAX NFKB2 CCND3 MAP3K7 CDKN1B ATM IRS1 PIK3R4 PIK3C2G PIK3C2A CCND2 PIK3C2B PIK3R5 ERBB2 MIR TARGETED GENES IN LEUKOCYTES%WIKIPATHWAYS_20260510%WP2003%HOMO SAPIENS miR targeted genes in leukocytes SH3BGRL3 ACP2 NELFCD CTSC SCYL1 SLC7A6 CDCP1 RFT1 FRG1 PTRH1 UNC93B1 ANAPC1 HEL-S-47e POLE4 PTPA SHOC2 CDIPT MAP3K8 CA12 AP3D1 ARCN1 WDR11 FMNL2 MAPK14 SPTLC1 IGF2R BCL2 CTNNB1 PRPF40A LPL USP1 DNAJB1 MTHFD2 FADS1 SRSF10 HEL-S-26 TPM3 ANXA2 CDK6 TYMS KCNN4 LAMTOR3 POLR2C HEL-S-30 GNA13 CEBPB CAP1 MCL1 GYS1 BCL6 SLC7A11 HMOX1 ATP2A2 TUBA1A YWHAQ PPIB HMGA1 SERPINE2 PLXND1 RDH10 TUSC2 ARID4B DCAF7 TXN2 PNP CHORDC1 GOLGA7 CDK5RAP3 THBS1 ARHG VPS39 ATP6V0E1 TNLG5A IFRD1 HEL-S-66 PISD RAB34 PPIF POM121 DDX5 RAB5C SLC1A4 ADIPOR2 RTN4 CORO1C MRPL20 SAC3D1 MPDU1 ATP6V1F SNX6 CD164 PHC2 BRPF3 TBCA MENT SFXN1 SLC25A1 ARF4 TRAM1 TMED10 ADPGK TNFAIP2 ADAR LMNB2 SNAP23 PRSS21 MRC2 TMEM43 TMED3 TMEM109 REGULATORY CIRCUITS OF STAT3 SIGNALING%WIKIPATHWAYS_20260510%WP4538%HOMO SAPIENS Regulatory circuits of STAT3 signaling MAPK12 MAPK11 IL2RG F2RL2 JAK3 IL9R MAPK9 IL5RA MAPK8 CSF2RB IL15RA JAK1 MAPK3 CREBBP PTPRT CNTFR MPL RPTOR IL6ST GHR DEPTOR DUSP2 MAPK14 IL11RA IL27RA OSMR IL20RA IFNGR1 IL20RB MLST8 TYK2 IL10RB IL10RA IL6R IFNLR1 PDGFRA MAPK15 IL22RA1 PTPRC IL3RA SOCS3 AKT1S1 IL2RB F2R IL21R IL2RA SRC EGFR CSF3R STAT3 MAPK10 MTOR SETD7 MAPK7 CTF1 MAPK1 AGTR1 AGTR2 MAPK13 IFNAR2 MAPK6 MAPK4 IFNAR1 F2RL3 MAPKAP1 RICTOR CSF2RA PRKCB TRIM28 IL7R IFNGR2 CATALYTIC CYCLE OF MAMMALIAN FLAVIN CONTAINING MONOOXYGENASES FMOS %WIKIPATHWAYS_20260510%WP688%HOMO SAPIENS Catalytic cycle of mammalian flavin containing monooxygenases FMOs FMO4 FMO5 PATHWAYS AFFECTED IN ADENOID CYSTIC CARCINOMA%WIKIPATHWAYS_20260510%WP3651%HOMO SAPIENS Pathways affected in adenoid cystic carcinoma NCOR1 CHEK1 EP300 BCOR PRKDC FOXO3A PTEN CREBBP MYC HRAS MAP2K2 JMJD1C TLK1 HIST1H1E CMTR2 MAGI1 SMC1A KDM6B FBXW7 HIST1H2AK INSRR ARID5B CTBP1 FOXP2 MORF4L1 MYBL1 KAT6A BCORL1 MYCBP PIK3CA SRCAP DTX4 MGA ERBIN KANSL1 NFIB MAML3 FGF16 SMARCE1 BRCA1 KMT2C MAX ARID1A FGFR4 ARID4B RAF1 CEBPA NOTCH1 ATM SETD2 MYB CHEK2 UHRF1 ERBB2 ANGIOPOIETIN LIKE PROTEIN 8 REGULATORY PATHWAY%WIKIPATHWAYS_20260510%WP3915%HOMO SAPIENS Angiopoietin like protein 8 regulatory pathway MAP2K3 MAP2K5 PRKAA2 MAPK9 MAPK8 MAP3K8 MAPK3 MAPK14 SESN3 LPL PIK3CA SCD IRS4 FASN CBLC RPS6KA4 MLXIPL MAP3K13 MAP3K12 FLOT1 FLOT2 FBP1 PTPN1 THRA HEL-S-42 TRIP10 PCK1 MAP3K11 CYP2B6 MAP3K1 MAPK1 RAF1 MAP3K14 MAP2K6 MAPK13 SLC2A4 MAPK6 CAP1 MAPK4 CYP3A4 MAP3K7 IRS1 PIK3R4 PIK3C2G PIK3C2A INS RPS6KA3 MAPK12 GYS1 MAPK11 SLCO1C1 GSK3A FOXO3A SLC16A2 PIK3CD RPTOR RPS6KB1 RPS6KB2 G6PC1 MLST8 NR1H3 HRAS MAP2K2 CYP7A1 ABCG8 TSC2 ABCG5 TSC1 RXRA ANGPTL8 SOS1 SOS2 MAP2K4 PDPK1 SHC1 CRK FOXO1 SHC3 CBL EIF4EBP1 INSR MAPK10 MTOR RHEB MAP3K2 MAP4K1 MAP4K2 MINK1 RAPGEF1 MAPK7 RPS6KA5 PRKAB2 PRKAB1 MAP4K3 EXOC7 SHC2 PIK3R3 MAP3K6 PIK3R2 PIK3R1 MAP3K10 RPS6KA6 RPS6KA2 RPS6KA1 PRKAG1 PRKAG2 PRKAG3 PRKAA1 MAPKAP1 RICTOR GSK3B SREBF2 EIF4E HEL-S-31 NR1A2 MAP3K5 MAP2K1 CILIARY LANDSCAPE%WIKIPATHWAYS_20260510%WP4352%HOMO SAPIENS Ciliary landscape YAP1 HEL-S-47e TFAP2A HEL113 CTNNB1 MCM7 NDUFA9 MCM3 NDUFA5 MCM5 IQGAP1 MCM6 MCM2 DYNC2I2 HDAC2 ACSL3 HDAC1 TRAF3IP1 SNRPB2 RB1 IFT172 CTBP2 MCM9 IFT52 WEE1 DGKE BBS9 UBE2D2 BBS7 SMC4 H3F3B PSMD7 CEP97 APMAP IFT57 RAB2A DYNC1LI1 IFT56 MYL6 BBS5 TIPRL BBS4 ERF ARL8B PSMD12 DYNLT1 INTU IFT140 PSMD13 HEL-S-296 IFT80 IQGAP3 CDH23 NUP88 LZTFL1 CDR2 AAR2 CTSA IFT43 NEK8 TFAP2C IFT81 UBE2H TFAP2D TFAP2E NFKB1 RHBDD2 EXOC6B CNOT10 IFT46 BBIP1 LSM4 TBC1D4 EHD3 IFT70B CNOT1 WNK1 LCN2 RANBP10 DYNLRB2 DYNLT2B NEF3 DOCK5 ZMYND19 MCM10 IFT74 MYL6B RPGR NEFL CEP170 TMED1 DFNB31 CEP290 NINL SNAP29 IQCB1 EIF5B BBS2 RBM14 BBS1 NUDC CNOT6L EXOC8 NUP133 EIPR1 FUZ DYNLT3 RAB3IL1 RALB ARFGAP3 DYNLL2 IFT20 RABEP2 NME8 TTC8 EXOC4 EXOC3 HTRA2 MKS1 EXOC6 IFT27 EXOC5 EFHC2 MAPRE2 EXOC2 PAFAH1B1 DNCL1 MAEA CCDC40 CLUAP1 GDI1 EXOC1 IFT25 IFT70A ECHS1 HEL-S-91n ARMC8 SSNA1 ANKS3 CREBBP VPS4A USH1C RAB21 RMND5B EXOSC4 DNPEP PGRMC2 STOM UQCC DYNC1H1 COPS7A LRPPRC PSMC6 RAB14 GLB1 PSMC4 CALM1 VAPB XPNPEP3 COPS4 GID8 COPS6 RQCD1 IFT22 YPEL5 COPS5 GLA COPS8 DVL3 RAB8A CAMK2A MFAP1 WDR26 CBS TFAP2B RMND5A APC MSH2 RANBP9 MKLN1 GID4 DCAF7 RAC1 EXOC7 POM121 DDX5 OPIOID RECEPTOR PATHWAYS%WIKIPATHWAYS_20260510%WP5093%HOMO SAPIENS Opioid receptor pathways SPINAL CORD INJURY%WIKIPATHWAYS_20260510%WP2431%HOMO SAPIENS Spinal cord injury TLR4 ANXA1 IL1R1 IL1A MAPK3 TGFB1 HEL113 IL2 PLA2G6 CDC2 ARHA CDK2 LTB4R RB1 E2F5 EGR1 CCR2 CHST11 ROS1 CDK4 CXCL1 MAPK1 CXCL2 ROCK2 CDC42 ACAN GJA1 SOX9 COL4A1 PTGS2 APEX1 COL2A1 PRKCA GRIN1 C1QB FOXO3A CCND1 MYC PPP3CA TNFSF13 IFNG CCL2 XYLT1 AQP4 AQP1 ZFP36 EPHA4 SEMA6A OMG MIF PDYN BCAN IL4 RTN4R PLA2G5 KLK8 EFNB2 PLXNA2 GFAP SELP GDNF EGFR CSPG4 BTG2 NCAN TACR1 RGMA NGFR MMP12 VCAN GAP43 LTB AIF1 NTN1 SLIT1 TNLG7A SLIT3 SLIT2 PLA2G2A LILRB3 FCGR2A NOS2 CCNG1 IL1B CD47 FKBP1A RAC1 ARG1 MMP9 RHOB MBP LEP TNF BDNF IL6 RTN4 GADD45A CXCL8 CDKN1B PRB1 PRB2 CASP3 NOX4 FOS 1P36 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP5345%HOMO SAPIENS 1p36 copy number variation syndrome PEX10 PEX12 HES5 RNF223 OR4F16 MORN1 TMEM278 FNDC10 RBX1 ANKRD65 PRKCZ INTS4 PLCH2 INTS9 VTN AGRN PARD6B SLC35E2B C1orf159 TGFB1 ARF6 SMAD2 SMAD4 GNB1 DVL1 SKI MCM2 DKK3 IFIH1 ELAVL1 PANK4 INTS11 INTS13 INTS14 INTS10 GDE1 TMEM52 GRIK2 CALML6 NOC2L IFIT1 METTL14 TNFRSF14 SDF4 PLEKHN1 CCNL2 TNFRSF4 SAMD11 MUSK TNFRSF18 HEL-S-72p SSU72 TRIM25 PEX2 ATAD3A ATAD3C GLTPD1 TRAF2 ACAP3 RER1 SCNN1D TRAF5 MMP23B C1QTNF12 PEX5 MXRA8 MRPL20 VWA1 AURKAIP1 TNLG2B TNLG2A PERM1 CD160 KLHL17 MEPCE LRP4 VEGFA UBE2J2 PHKG2 BTLA PUSL1 TAS1R3 NADK HES4 COMMD1 OR4F5 OR4F3 CDK11A CFAP74 MIB2 ISG15 B3GALT6 MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY%WIKIPATHWAYS_20260510%WP1544%HOMO SAPIENS MicroRNAs in cardiomyocyte hypertrophy MAP2K3 MAP2K5 CDK9 MAPK8 MYLK3 CISH HDAC9 MAPK3 TGFB1 PIK3CD IGF1R IL6ST MAPK14 PPP3CA ARHA FGF2 HDAC5 CDK7 MYLK MAP2K2 CALM1 CTNNB1 EIF2B5 MAP2K4 DVL1 LIF PDPK1 NRG1 PIK3CA LRP5 NFATC4 CAMK2D LRP6 MAP3K7IP1 GATA4 IGF1 IKBKE EGF STAT3 MTOR PLA2G2A FZD1 HDAC7 FGFR2 IKBKB MAPK7 CTF1 CHUK MYEF2 FZD2 MAPK1 IKBKG WNT3A RAC1 RAF1 ROCK1 PLCB2 ROCK2 MAP3K14 NFKB1 MAP2K6 PIK3R3 TNF PIK3R2 PIK3R1 MAPK4 PRKG1 GSK3B EDN1 PRKCB NPPB NPPA MAP2K1 FATTY ACID TRANSPORTERS%WIKIPATHWAYS_20260510%WP5061%HOMO SAPIENS Fatty acid transporters FABP1 SLC27A4 ACSL1 FABP9 FACL4 FABP5 ACSL3 FABP6 FABP2 ACSL6 ACSL5 CD36 DBI FABP4 SENESCENCE AND AUTOPHAGY IN CANCER%WIKIPATHWAYS_20260510%WP615%HOMO SAPIENS Senescence and autophagy in cancer MAP2K3 CDC25B MAP1LC3C VTN CDKN1A IL1A PLAT PTEN TGFB1 IL24 ING1 IRF1 ULK1 IGF1R LAMP2 DKFZp762B153 SLC39A2 IL6ST SLC39A1 BRAF SLC39A3 SERPINB2 MAPK14 SH3GLB1 TNLG1B SMAD4 IGFBP5 RNASEL MAP1LC3A MLST8 AMBRA1 HRAS IFI16 ATG5 IL6R ATG3 CREG1 ATG10 CCL3 IGFBP7 IFNG UVRAG BCL2 RSL1D1 ATG14 IL3 ATG12 AKT1S1 ATG16L1 BMP2 JUN RB1CC1 SRC PCNA RB1 SPARC CXCL14 IGF1 IRF7 MTOR KMT2A HMGA1 CDKN2A MDM2 BMI1 INHBA SQSTM1 CD44 MMP14 IL1B CXCL1 MAPK1 THBS1 RAF1 CEBPB IL6 COL10A1 GABARAPL2 GABARAPL1 IFNB1 GSK3B CXCL8 COL1A1 COL3A1 CDKN1B GABARAP MAP2K1 INS DISORDERS IN KETOLYSIS%WIKIPATHWAYS_20260510%WP5195%HOMO SAPIENS Disorders in ketolysis BDH1 OXCT1 ACAT2 ACAT1 HMGCS1 AMINO ACID METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260510%WP5213%HOMO SAPIENS Amino acid metabolism in triple negative breast cancer cells SLC7A11 GLS PSAT1 PHGDH PSPH OXYSTEROLS DERIVED FROM CHOLESTEROL%WIKIPATHWAYS_20260510%WP4545%HOMO SAPIENS Oxysterols derived from cholesterol HSD11B1 HSD11B2 SULT2B1 RORC CYP46A1 NR3A2 SLC27A2 IL17B CYP7A1 CYP8B1 DHCR7 IL25 INSIG1 DBP THEM5 HSD3B7 LBP CYP3A4 ACOT9 ACOT8 ACOT7 ACOT11 AKR1D1 ACOT12 ACOT13 AKR1C4 CH25H EBP BAAT GPR183 IL17F IL17D ACOT6 CYP7B1 IL17C IL17A CYP27A1 ACOT4 EPHX2 AMACR SULT2A1 SLC27A5 NR1i2 NR1H2 SYNAPTIC SIGNALING ASSOCIATED WITH AUTISM SPECTRUM DISORDER%WIKIPATHWAYS_20260510%WP4539%HOMO SAPIENS Synaptic signaling associated with autism spectrum disorder MTOR PRKAA2 CACNA1C ARC RHEB KRAS MAPK3 PTEN PIK3CD CAMK4 RPTOR PRKAB2 RPS6KB1 MAPK1 PRKAB1 AKT3 HRAS PIK3R3 PIK3R2 BDNF PIK3R1 TSC2 NRAS TSC1 PRKAG1 PRKAG2 PRKAA1 PRKAG3 GSK3B NF1 SYNGAP1 PIK3CA UBE3A HOMER1 GRIN3B GRIN2B GRIN3A GRIN1 DLG4 SHANK3 EIF4EBP1 NTRK2 WARBURG EFFECT MODULATED BY DEUBIQUITINATING ENZYMES AND THEIR SUBSTRATES%WIKIPATHWAYS_20260510%WP5216%HOMO SAPIENS Warburg effect modulated by deubiquitinating enzymes and their substrates OTUD6B MTOR HIF1A VHL PGAM1 VEGFA PIK3CA U2AF2 OTUB2 FOXO1 USP37 G6PC1 USP44 HEL-S-133P MYC OTUD7B SIRT7 KDR HEL-S-68p USP28 USP19 HK2 FBP1 MALATE ASPARTATE SHUTTLE%WIKIPATHWAYS_20260510%WP4315%HOMO SAPIENS Malate aspartate shuttle SLC1A3 SLC25A11 GOT2 HEL-S-32 DEREGULATION OF RAB AND RAB EFFECTOR GENES IN BLADDER CANCER%WIKIPATHWAYS_20260510%WP2291%HOMO SAPIENS Deregulation of Rab and Rab effector genes in bladder cancer MADD SYTL1 RAB27B MYRIP SYTL5 UNC13D TBC1D10A SYTL2 EXPH5 MLPH RAB27A RPH3A CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260510%WP197%HOMO SAPIENS Cholesterol biosynthesis pathway DHCR7 HMGCS1 HMGCR IDI1 SC5D FDPS MVK MSMO1 SQLE PMVK MVD FDFT1 CYP51A1 MEVALONATE PATHWAY%WIKIPATHWAYS_20260510%WP3963%HOMO SAPIENS Mevalonate pathway HMGCR FDPS MVK ACAT2 PMVK HMGCS1 MVD CHOLESTEROL METABOLISM WITH BLOCH AND KANDUTSCH RUSSELL PATHWAYS%WIKIPATHWAYS_20260510%WP4718%HOMO SAPIENS Cholesterol metabolism with Bloch and Kandutsch Russell pathways ELOVL4 CYP46A1 MSMO1 TM7SF2 ABCG1 NR1H3 LBR SOAT2 ABCA1 MYLIP DHCR7 SOAT1 HMGCS1 ELOVL5 ACSL1 ELOVL2 SREBF2 HSD17B7 CH25H EBP ELOVL3 FACL4 HMGCR IDI1 SC5D ACSL3 FADS2 FDPS CYP27A1 MVK SCD GGPS1 FASN FADS1 ACAT2 DHCR24 SQLE PMVK NR1H2 MVD FDFT1 CYP51A1 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260510%WP4249%HOMO SAPIENS Hedgehog signaling IHH CSNK1A1L SHH PTCH1 BOC CDON CSNK1G3 SMO ADRBK1 SMURF2 SMURF1 FBXL17 GPR161 HHIP SPOPL GAS1 CSNK1G2 CCND1 EVC SUFU BCL2 KIF7 PRKACG ARRB2 DHH KIF3A PTCH2 SPOP EVC2 CSNK1D CSNK1E GLI3 CSNK1G1 CCND2 CSNK1A1 MIR TARGETED GENES IN ADIPOCYTES%WIKIPATHWAYS_20260510%WP2001%HOMO SAPIENS miR targeted genes in adipocytes CEBPB TGFBR2 CAP1 LPL ELOVL5 CYP1B1 PHC2 SRSF9 TMED10 PICALM SRSF10 FADS1 IGF2R TMEM43 ADIPOGENESIS%WIKIPATHWAYS_20260510%WP236%HOMO SAPIENS Adipogenesis CREB1 PTGIS TGFB1 CNTFR NCOA1 CELF1 SOCS1 SP1 CTNNB1 LPL RBL2 RBL1 BMP2 SCD RB1 IRS4 E2F4 GATA4 IGF1 MEF2C MEF2B PCK1 WNT5B SFRP4 PPARG MEF2D WNT10B LMNA CISD1 MBNL1 GTF3A PRLR CYP26A1 ADFP TRIB3 ZMPSTE24 NDN GH1 BMP3 ID3 SLC2A4 CEBPB ASIP SPOCK1 GDF10 OSM KLF7 PNPLA3 CYP26B1 MIXL1 NAMPT STAT2 NCOR2 KLF6 FOXC2 CFD IRS1 TWIST1 INS NCOR1 NR3C1 CDKN1A STAT5B RORA NR1C2 STAT1 AHR IL6ST LPIN1 PCK2 FAS NR1H3 NR1C1 WWTR1 RXRA GATA3 HIF1A SOCS3 RARA MIF BMP1 DVL1 LIF RETN DDIT3 FOXO1 WNT1 GATA2 STAT3 HMGA1 FRZB FZD1 HNF1A BMP4 LEP CEBPA CEBPD TNF LIPE EGR2 IL6 KLF15 KLF5 GADD45B GADD45A PLIN1 UCP1 BSCL2 LPIN2 LPIN3 RXRG NR2F1 PPARGC1A BILE ACID SYNTHESIS AND ENTEROHEPATIC CIRCULATION %WIKIPATHWAYS_20260510%WP4389%HOMO SAPIENS Bile acid synthesis and enterohepatic circulation MAPK3 CYP7A1 ABCG8 ABCB11 ABCG5 FGF8A MAPK1 FXR1 LDLR SLC10A2 FGFR4 EPAC1 AND PKA REDUCTION OF RETINAL INFLAMMATION%WIKIPATHWAYS_20260510%WP5440%HOMO SAPIENS EPAC1 and PKA reduction of retinal inflammation IL1B NLRP3 PRKAR1B PRKAR1A OMEGA 3 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260510%WP5432%HOMO SAPIENS Omega 3 fatty acids in senescence ALOX15 PTGIS CYP3A4 HPGD GPR32 PTGS2 ELOVL5 PTGS1 FPR2 CYP2C9 PTGES ELOVL2 LTC4S CYP2C8 CYP1A2 ALOX15B FADS2 ALOX5 EPHX2 FADS1 GSTM4 ALOX12 HEL-S-22 CYP2E1 CORI CYCLE%WIKIPATHWAYS_20260510%WP1946%HOMO SAPIENS Cori cycle SLC2A2 HEL-S-49 SLC2A4 PFKP HEL-S-87p HEL-S-133P GPT INS PGAM1 HEL-S-68p HEL-S-162eP NANOPARTICLE TRIGGERED AUTOPHAGIC CELL DEATH%WIKIPATHWAYS_20260510%WP2509%HOMO SAPIENS Nanoparticle triggered autophagic cell death ATG10 UVRAG INSR BCL2 TSC2 TSC1 ATG14 ATG12 ATG16L1 ATG9B ULK2 VMP1 CHAF1A ULK1 SH3GLB1 INS AMBRA1 MAP1LC3A ATG5 ATG3 ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20260510%WP554%HOMO SAPIENS ACE inhibitor pathway ACE2 NR3C2 ATP6AP2 KNG1 REN BDKRB2 BDKRB1 MGRA TGFB1 CTSG CMA1 CYP11B2 AGTR1 AGTR2 INFLUENCE OF LAMINOPATHIES ON WNT SIGNALING%WIKIPATHWAYS_20260510%WP4844%HOMO SAPIENS Influence of laminopathies on Wnt signaling HES5 TCF7L1 CSNK1A1L APC PPARG RUNX2 CDK6 HES1 WNT10B LMNA CCND1 ZMPSTE24 CEBPA CEBPD SLC2A4 CTNNB1 CEBPB SPP1 GSK3B TOR1AIP1 FNTA EMD TCF7L2 ICMT LEF1 HMGA2 AXIN1 DICER1 AGO2 TARBP2 CSNK1A1 CONTROL OF IMMUNE TOLERANCE BY VASOACTIVE INTESTINAL PEPTIDE%WIKIPATHWAYS_20260510%WP4484%HOMO SAPIENS Control of immune tolerance by vasoactive intestinal peptide IFNG IL12A TGFB1 CTLA4 VIP CD80 IL2 FAS IL5 IL10 IL4 SPHINGOLIPID METABOLISM INTEGRATED PATHWAY%WIKIPATHWAYS_20260510%WP4726%HOMO SAPIENS Sphingolipid metabolism integrated pathway PLPP2 CERK PLPP1 SGMS1 SPHK1 SGMS2 UGT8 UGCG KDSR CERS1 CERS2 SPHK2 SGPP2 SGPP1 SGPL1 SPTLC2 SPTLC1 SMPD1 CERS3 DEGS1 CERS5 DEGS2 CERS6 PLPP3 VASOPRESSIN REGULATED WATER REABSORPTION%WIKIPATHWAYS_20260510%WP5085%HOMO SAPIENS Vasopressin regulated water reabsorption DYNLL2 CREB1 DCTN6 ADCY6 DCTN5 RAB5B DCTN1 DCTN4 ARHGDIG HEL-S-77 AQP2 DYNC1LI1 ARHGDIB DNCL1 HEL-S-47e STX4A DYNC1I1 DYNC2H1 AVPR2 RAB11A RAB11B DYNC1LI2 CREB3L3 AVP CREB3L4 RAB5A CREB3L2 CREB3 DYNC1H1 GNAS CREB5 RAB5C VAMP2 AQP3 PRKACG AQP4 DYNC2LI1 ADCY9 ADCY3 EFFECT OF DASATINIB ON THE BCR ABL SIGNALING PATHWAY%WIKIPATHWAYS_20260510%WP5493%HOMO SAPIENS Effect of dasatinib on the BCR ABL signaling pathway INPP5D EIF4B GAB2 BCL9 MAPK11 DOK1 KRAS GRB2 HSPB2-C11orf52 MAP3K2 MAPK3 BCLAF1 ARAF VAV1 SPAG1 BRAF MAPK1 MAPK14 RAF1 AKT3 HRAS SHC2 BCL2 PIK3R1 NRAS RPS6KA1 CRKL SOS1 PXN PIK3CA SHC1 SRC BCR CRK SHC4 SHC3 HEL-S-102 ATF2 CBL MEF2C EXRNA MECHANISM OF ACTION AND BIOGENESIS%WIKIPATHWAYS_20260510%WP2805%HOMO SAPIENS exRNA mechanism of action and biogenesis XPO5 DGCR8 DROSHA ERI1 AGO2 DICER1 MONOAMINE GPCRS%WIKIPATHWAYS_20260510%WP58%HOMO SAPIENS Monoamine GPCRs HTR2A ADRB1 HTR1E HTR1F ADRB2 HTR1D HTR1B 5HT1A HTR2B HTR4 HRH1 HTR6 HTR7 HRH2 DRD5 ADRA2C CHRM2 HTR5A CHRM3 ADRA2B ADRA2A CHRM1 CHRM4 CHRM5 ADRA1D DRD4 ADRA1B DRD1 ADRA1A DRD2 DRD3 ADRB3 DOPAMINERGIC NEUROGENESIS%WIKIPATHWAYS_20260510%WP2855%HOMO SAPIENS Dopaminergic neurogenesis STAT3 SHH FOXA2 TGFB1 ASCL1 HEL-S-53e NEUROD1 GBX2 SLC6A3 DDC OTX2 CDKN1C MSX1 TH FGF8 NKX6-1 SLC18A2 NKX2-2 PITX3 EN2 SOX2 EN1 LMX1A LMX1B NEUROG2 RET WNT1 AUTOSOMAL RECESSIVE OSTEOPETROSIS PATHWAYS%WIKIPATHWAYS_20260510%WP4788%HOMO SAPIENS Autosomal recessive osteopetrosis pathways TCIRG1 TNFRSF11A RAB7A IKBKB TNFSF11 TRAF6 CLCN7 NFKB1 OSTM1 PLEKHM1 SNX10 RENIN ANGIOTENSIN SYSTEM AND BRADYKININ PATHWAYS IN COVID 19%WIKIPATHWAYS_20260510%WP4969%HOMO SAPIENS Renin Angiotensin System and Bradykinin pathways in COVID 19 TNF ACE2 PRKG1 CYP3A4 KNG1 REN BDKRB2 CYP24A1 BDKRB1 IL1A SERPING1 CPN1 IL1B KLNA1 KLKB1 MAPK1 AGTR1 ROCK1 AGTR2 NFKB1 ARHA NR1i1 GPR143 IN MELANOCYTES AND RETINAL PIGMENT EPITHELIUM CELLS%WIKIPATHWAYS_20260510%WP4941%HOMO SAPIENS GPR143 in melanocytes and retinal pigment epithelium cells CREB1 ASIP PLCB4 PRKACG ARRB2 GNA15 TYR PLCB1 VEGFA PLCB3 PRKCB PMEL TYRP1 GPR143 MC1R DCT ADCY9 POMC PLCB2 GNAS 5Q35 COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5380%HOMO SAPIENS 5q35 copy number variation INPP5D HK3 MAPK9 MAPK8 PLCG1 USH1C IGF1R CXCR4 MYC UIMC1 CYP7A1 ABRAXAS1 BRCC3 KDM6B FBXW7 CLTB SOS1 JUN SRC RGS14 PRR7 KIAA1191 FAF2 DDX41 GNAI3 TRIAP1 HEL-S-273 BABAM1 BABAM2 CAPN3 GNAI1 NELFB NTN1 ARL10 MAPK10 TMED9 RNF44 H3F3B UNC5A BRCA1 EED MYO7B FGF8A ARFGAP2 EIF4E1B HIC2 PTH SLC34A1 DOK3 MAX GPRIN1 GRB2 CDHR2 FAM193B FGFR4 PFN3 DBN1 MAGED1 ABHD5 COX7A1 LMAN2 RAB24 ZNF346 SNCB BARD1 PDLIM7 SNCA PRELID1 PTPRN2 NOP16 MUPCDH HIGD2A TSPAN17 ANKS4B COX7B RNP24 MXD3 PIK3R1 COX4I1 COX6A1 COX7C DRD2 FRS2 COX5A COX3 COX2 COX8A H2AX PNPLA2 COX6B1 TMED10 GRIN2B ADAM10 GRIN1 VITAMIN K METABOLISM AND ACTIVATION OF DEPENDENT PROTEINS%WIKIPATHWAYS_20260510%WP5186%HOMO SAPIENS Vitamin K metabolism and activation of dependent proteins VKORC1 UBIAD1 F2 F9 PROC F10 NQO1 GGCX PROS1 PROZ AIFM2 F7 15Q25 COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5408%HOMO SAPIENS 15q25 copy number variation SYNJ1 ALPK3 EGF ZSCAN2 SHANK1 AP3D1 PDE8A RAF1 RYR1 RYR2 SH3GL3 RAMAC ZNF592 AGAP2 TENT4B RNMT BTBD1 GOLGA6L4 ADAMTSL3 C15orf40 HTT FSD2 AP3S1 WHAMM SEC11A NMB BNC1 HOMER2 NMBR WDR73 TM6SF1 AP3B2 SHANK3 DNM3 SPCS3 SPCS2 SPCS1 NON CLASSICAL ROLE OF VITAMIN D%WIKIPATHWAYS_20260510%WP5133%HOMO SAPIENS Non classical role of vitamin D ACE2 AGTR1 AGTR2 REN CYP27B1 CYP2R1 PHOTODYNAMIC THERAPY INDUCED AP 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260510%WP3611%HOMO SAPIENS Photodynamic therapy induced AP 1 survival signaling MCL1 MAP2K3 MAPK12 TNFSF10 BMF MAPK11 BCL2L11 CDKN2A TNFSF6 BCL2L1 MAPK8 CDKN1A TRAF6 CCND1 MAPK14 IL2 MMP2 FAS MAP2K6 MAPK13 PDGFRA IFNG BCL2 TNF FGF7 TRAF2 IL6 TRAF5 BAK1 CCNA2 MAP2K4 JUN BAX CCNE1 NFE2L2 RB1 EGFR JUNB MAP3K5 TNFRSF1A HBEGF ATF2 FOS 15Q11Q13 COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5407%HOMO SAPIENS 15q11q13 copy number variation MTMR10 RELA SPEF1 OTUD7A SMC5 SMC6 ANKRD32 ANKRD2 GOLGA8R GOLGA8T KLF13 CXADR NSMCE3 NSMCE2 CREBBP NSMCE1 GOLGA8K GOLGA8J GOLGA8O GOLGA8Q GJD3 CANX GOLGA8H MYZAP FAN1 STXBP1 STX1A CCL5 NECAB3 CHRNA7 STX1B LYPD6 ENTREP2 CALM1 FANCD2 TRPM1 UBN1 MLSN2 SLF2 CGN CDC42BPB TJP3 HDAC1 TJP1 SIN3A CXNO GJA1 APP KAT2B TNF ALPHA SIGNALING%WIKIPATHWAYS_20260510%WP231%HOMO SAPIENS TNF alpha signaling DIABLO MAP2K3 APAF1 SKP1 CASP8 PRKCZ FADD BCL2L1 MAPK9 MAPK8 MAP3K8 MAPK3 CREBBP PYGL CYBA PLK1 CDC37 HRAS PPP2CA KSR1 TNFAIP3 SMPD2 PSMD2 PIG59 RIPK3 SOS1 FBXW11 MAP2K4 KSR2 TNFRSF1B JUN PTPRCAP NSMAF RFFL MAP3K7IP1 OTUD7B TBK1 BTRC MADD NFKBIB CSNK2A1 REL KRAS GRB2 NFKBIE MAP4K2 TAB3 TRAF1 IKBKB BIRC3 TXN NFKBIA MAP3K1 CHUK TRADD MAPK1 IKBKG RAC1 RAF1 MAP3K14 NFKB1 MAP2K6 TNF TRAF2 NRAS BIRC2 TANK RIPK1 BAD BAX CASP9 NFKB2 MAP3K7 CASP3 MAP3K5 TNFRSF1A GDNF RET SIGNALING AXIS%WIKIPATHWAYS_20260510%WP4830%HOMO SAPIENS GDNF RET signaling axis SLIT2 IFT27 SOX17 IFT25 BMP4 SPRY1 AGTR2 WT1 CTNNB1 GATA3 PAX2 SIX2 ALDH1A2 RET SOX11 ROBO2 FOXC2 FOXC1 HOXD11 HOXC11 GDNF HOXA11 ROBO1 SALL1 GLI3 EYA1 GREM1 LHX1 FAT4 TCF2 EMBRYONIC STEM CELL PLURIPOTENCY PATHWAYS%WIKIPATHWAYS_20260510%WP3931%HOMO SAPIENS Embryonic stem cell pluripotency pathways MAP2K3 MAP2K5 BRAF SMAD4 FGF2 CTNNB1 FGF7 FGF8 FGF9 SMAD1 SMAD9 DKFZp781O1323 JUN WNT4 FGF20 BMPR1A BMPR2 FGF23 FGF22 FGF21 ACVR1 FGF16 FGF14 ACTR2 FGF18 ERAS FGF13 ACVR2B FGF12 FGF10 WNT2B WNT5B FGF8A WNT9B WNT16 WNT3 FGF7B WNT10B WNT10A FZD3 FGF7A FZD2 FZD5 FZD4 MAPK1 WNT3A RAF1 WNT7B FZD7 FZD9 MAP2K6 FGF6B WNT7A FZD8 MAPK6 MAPK4 FGF5C MAPK12 JAK1 PTEN PIK3CD IL6ST AKT3 HRAS PDGFRA MAP2K2 NOG SOS1 DVL1 LIF DVL2 SMAD6 DVL3 AXIN1 LRP5 EGFR LRP6 WNT1 EGF STAT3 MTOR APC PDGFA MDM2 FZD1 GRB2 HNF1A FGFR4 FGFR3 BMP4 FGFR2 FGFR1 MAPK7 ARAF PIK3R2 PTPN11 GSK3B MAP2K1 SELENOP FOS 2Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP5223%HOMO SAPIENS 2q21 1 copy number variation syndrome CDC27 STAT3 AMER3 STMN2 MZT2A APC FAM168B CCDC74A POTEE GPR148 TUBA2 CCDC42 ARHGEF4 RAC1 ARHA SULFATION BIOTRANSFORMATION REACTION%WIKIPATHWAYS_20260510%WP692%HOMO SAPIENS Sulfation biotransformation reaction SULT2B1 SULT1E1 SULT6B1 SULT1C3 SULT1C2 PAPSS2 PAPSS1 SULT1A4 SULT1C4 HEL-75 SULT1A1 SULT2A1 SULT1A2 SULT1B1 GAMMA GLUTAMYL CYCLE FOR THE BIOSYNTHESIS AND DEGRADATION OF GLUTATHIONE%WIKIPATHWAYS_20260510%WP4518%HOMO SAPIENS Gamma glutamyl cycle for the biosynthesis and degradation of glutathione HEL-S-64p OPLAH GCLC C7orf24 STING PATHWAY IN KAWASAKI LIKE DISEASE AND COVID 19%WIKIPATHWAYS_20260510%WP4961%HOMO SAPIENS STING pathway in Kawasaki like disease and COVID 19 MITA IKBKE IRF3 F3 RELA REL FCGR2A NLRP3 IFNB1 GSDMD NFKBIE IKBKB IL1B NFKBIA CHUK IKBKG NLRX1 CGAS NFKB1 TBK1 GLYCOSAMINOGLYCAN SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260510%WP5395%HOMO SAPIENS Glycosaminoglycan synthesis in fibroblasts CHST3 HS3ST3A1 CHST11 CHST12 CHPF CHST13 HS3ST1 XYLT2 CHST14 HS3ST2 EXTL2 EXTL1 CHSY1 CHSY3 CSGALNACT1 CHPF2 B3GAT3 B3GAT2 GLCE B3GAT1 CSGALNACT2 UST HS2ST1 XYLT1 EXT1 EXT2 HS3ST3B1 CHST7 CHST1 HS6ST1 HS6ST2 HS6ST3 NDST3 B3GALT6 HINT1 PATHWAY%WIKIPATHWAYS_20260510%WP5523%HOMO SAPIENS HINT1 pathway HINT1 NFATC2 RUVBL2 RUVBL1 CTNNB1 TCF4 GTF2H2C_2 MAPK9 GTF2H2 GTF2H3 GTF2H5 JUN ERCC2 MNAT1 CCNH NFKB1 KARS1 FOS USF2 SH3RF1 CDK7 ACUTE VIRAL MYOCARDITIS%WIKIPATHWAYS_20260510%WP4298%HOMO SAPIENS Acute viral myocarditis CREB1 TLR4 CASP8 BCL2L1 DAG1 IL12B IL10 JAK1 CXADR MAPK3 IL12A CCR5 HEL-S-28 TGFB1 EIF4G1 CD55 STAT1 CD40LG CCND1 CXCR4 IL2 SOCS1 CYCS IFNG BCL2 HLA-DMA SOS1 SRC TLR5 CCR3 ABL2 AIF1 TICAM1 STAT3 FYN TLR3 PS1TP5BP1 RAC3 MAPK1 MMP9 TNF CAAP1 PIK3R1 PYCARD SGCD IL6 SGCA CASP6 SGCB CASP2 SGCG DFFB DFFA PABPC1 MYH6 GSK3B EDN1 CHRAC1 BNIP2 BAX DMD CASP9 MICA NFKB2 AAG1 CD80 CASP3 NOD2 PARP1 BIOTIN METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260510%WP5031%HOMO SAPIENS Biotin metabolism including IMDs PC MCCC2 BTD HLCS MCCC1 ACACB PCCA ACACA PCCB GANGLIO SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260510%WP1423%HOMO SAPIENS Ganglio sphingolipid metabolism ST8SIA1 B3GALT4 ST8SIA5 ST3GAL5 B4GALNT1 SLC33A1 B3GALT1 FUT1 A3GALT2 ST3GAL1 ST6GALNAC6 PHYSICO CHEMICAL FEATURES AND TOXICITY ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260510%WP3680%HOMO SAPIENS Physico chemical features and toxicity associated pathways MAPK8 DAAM1 CDKN1A PLCG1 MYC ARHA MYLK PPP2CA CTNNB1 HEL-S-44 MYL1 SOS1 NCK1 PFN1 MAP2K4 DVL1 JUN SHC1 SRC AXIN1 EGFR TGFA CBL ACTR2 FZD10 APC TMSB4X WNT16 FZD1 GRB2 PFN3 FZD3 FZD2 FZD5 MAPK1 FZD4 CAMK1 RAF1 ROCK2 FZD7 FZD9 FZD8 PAK1 ERBB4 NEF3 GPX1 NEFL GSK3B CDKN1B ACTA1 MAP2K1 NEFH ACTR3 PFN4 PFN2 ERBB2 KALLMANN SYNDROME%WIKIPATHWAYS_20260510%WP5074%HOMO SAPIENS Kallmann syndrome MYRF MAP2K2 LHB SEMA3E OTX2 OLIG2 SOX10 FGF8 TMEM98 ANOS1 PROK2 GNRH1 FRS2 NEUROG1 GRB2 PTPN11 PLXND1 PIK3CA FGFR1 MAPK1 ASCL1 KENNEDY PATHWAY FROM SPHINGOLIPIDS%WIKIPATHWAYS_20260510%WP3933%HOMO SAPIENS Kennedy pathway from sphingolipids CEPT1 PEMT PTDSS2 SGPL1 PTDSS1 PCYT1B CHKB PCYT2 CHKA ETNK1 PISD UREA CYCLE AND ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260510%WP4595%HOMO SAPIENS Urea cycle and associated pathways ASL NAGS MDH2 GOT2 NOS2 GLS2 SLC25A15 LDHB GLUD1 SLC25A12 SLC25A13 OTC FH HEL-S-32 GPT ARG1 ASS1 HLA C ALLOTYPES INTERACTIONS WITH KIR ON DNK CELLS%WIKIPATHWAYS_20260510%WP5580%HOMO SAPIENS HLA C allotypes interactions with KIR on dNK cells IFNG TNF CSF2 FYN PTPN6 HLA-C PLCG1 LCP2 SYK LAT PRKCA VAV1 KIR2DL1 KIR2DL3 TYROBP NLRP7 NLRP2 RAC1 ELF3 PRKCQ TGF BETA RECEPTOR SIGNALING IN SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260510%WP4816%HOMO SAPIENS TGF beta receptor signaling in skeletal dysplasias EP300 MAPK9 JAK1 MAPK3 CREBBP TGFB1 STAT1 ADAMTSL2 SMAD2 SMAD4 pp6425 FBN1 HRAS TGFBR1 LEFTY1 IFNG CTNNB1 ZFYVE9 ITGB6 SMAD1 NOG SMAD9 FOXH1 RUNX3 ENG FST LTBP1 SKIL DKFZp781O1323 LIF LEFTY2 JUN SMAD6 SKI BAMBI LEF1 WNT1 EGF STAT3 TGFBR3 INHBA RUNX2 BMP4 FKBP1A THBS1 NFKB1 TNF TGFBR2 ZNF423 SPP1 ZEB2 TGIF1 FOS ASPIRIN PREVENTION OF CANCER METASTASIS%WIKIPATHWAYS_20260510%WP5518%HOMO SAPIENS Aspirin prevention of cancer metastasis TBXA2R ARHGEF1 ARHA PTGS1 GNA13 ISOGLOBO SERIES SPHINGOLIPIDS%WIKIPATHWAYS_20260510%WP5311%HOMO SAPIENS Isoglobo series sphingolipids B3GALT5 KCNQ2 RELATED EPILEPSIES%WIKIPATHWAYS_20260510%WP5360%HOMO SAPIENS KCNQ2 related epilepsies CHRM1 CALM1 AKAP5 CSNK2A1 KCNQ2 KCNQ3 BDKRB2 PLCG2 PRKCA PPP3CC AGTR1 PPP1R10 BACE1 STX1A P2RY1 SCN1B GDNF SIGNALING%WIKIPATHWAYS_20260510%WP5143%HOMO SAPIENS GDNF signaling MOLYBDENUM COFACTOR MOCO BIOSYNTHESIS%WIKIPATHWAYS_20260510%WP4507%HOMO SAPIENS Molybdenum cofactor Moco biosynthesis MOCS2 MTARC2 MOCS1 GPHN AOX1 XDH SUOX NSAIDS MECHANISM OF ACTION%WIKIPATHWAYS_20260510%WP5513%HOMO SAPIENS NSAIDs mechanism of action PTGS2 PTGS1 PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS %WIKIPATHWAYS_20260510%WP2572%HOMO SAPIENS Primary focal segmental glomerulosclerosis FSGS TLR4 LAMB2 VTN AGRN DAG1 CDKN1A PLCG1 HEL-S-28 TGFB1 SMARCAL1 HEL113 CD151 PLCE1 TLN1 CTNNB1 CDKN1C SCARB2 PTPRO MKI67 SYNPO KIRREL3 TRPC6 KIRREL2 DKK1 LMX1B YWHAQ MME PLAUR ACTN4 NCK1 CD2AP INF2 MYH9 PARVA MYO1E NPHS1 PCNA NPHS2 LRP5 LIMS1 ITGB3 LRP6 WNT1 CLDN1 ITGAV CTSL CDH2 ITGB1 FYN LAMA5 HEL114 WT1 IRF6 CR1 PAX2 NOTCH1 COL4A4 COL4A3 COL4A5 ITGB4 FAT1 CDKN1B CD80 METABOLIC EPILEPTIC DISORDERS%WIKIPATHWAYS_20260510%WP5355%HOMO SAPIENS Metabolic epileptic disorders HK3 GLDC PGAM1 ECHS1 SHMT1 AMT SLC25A15 ALDH7A1 LDHB GLUD1 ALDOB DLD G6PC1 MOCS2 MOCS1 GPHN XDH MOCS3 ENO2 ENO3 DHTKD1 MPC1 PDHA1 HEL-S-32 MPC2 AASS SLC25A5 FBP2 HK2 FBP1 GCDH SLC2A2 SLC7A2 PC PKLR CBS AADAT DLAT SQOR PCK1 GCK CDO1 HEL60 PSAT1 PHGDH GLS2 HEL-S-51e PSPH OTC HEL-S-87p HEL-S-30 PGAM2 HEL-S-133P GPT ENO1 ARG1 HEL-S-68p ASS1 PFKM HEL-S-162eP ASL HEL-S-49 SLC2A4 MDH2 GOT2 PFKP HEL-S-20 SLC2A3 ETHE1 SUOX PFKL SFXN1 SLC25A1 BTD HLCS CTH ACAT1 SPCS1 TRANSCRIPTION ACTIVATION RNA POLYMERASE I AND KAT2A B AND INHIBITION NURD COMPLEX %WIKIPATHWAYS_20260510%WP5565%HOMO SAPIENS Transcription activation RNA polymerase I and KAT2A B and inhibition NuRD complex H2AB1 EP300 H2AJ H3C15 POLR1A POLR1C MAPK3 POLR1D CREBBP SRCAP HDAC2 HDAC1 SIRT7 RBBP4 H3F3B PWWP2B H2AC19 CHD4 H2AC14 H2BC26 H2BC12L H2BC21 TLK2 UBTF PWWP2A HIST1H2AB H2AC6 H2BC17 H2BC12 H2BC13 KAT2A H2AZ1 TBP H2BC14 H2BC15 H4C9 HAT1 H2BC11 HIST1H2BE HIST1H4L ASF1A ASF1B RRN3 TAF1D TAF1B EP400 H2BC9 MBD3 H2BC8 TAF12 H2BC3 MBD2 H2BC1 GATAD2A H2AC20 CDK2AP1 H2AX CHD3 GATAD2B MTA2 H2AZ2 H3C8 KAT2B NANOMATERIAL INDUCED INFLAMMASOME ACTIVATION%WIKIPATHWAYS_20260510%WP3890%HOMO SAPIENS Nanomaterial induced inflammasome activation IL1B TLR4 PYCARD NFKB1 ENDOCHONDRAL OSSIFICATION%WIKIPATHWAYS_20260510%WP474%HOMO SAPIENS Endochondral ossification PLAT STAT5B TGFB1 MGP SOX6 STAT1 IGF1R GHR IGF2 FGF2 CALM1 CDKN1C RUNX3 BMP6 BMPR1A GLI3 IGF1 MEF2C THRA FGF18 IHH PTH1R PTHLH PTH FRZB PTCH1 CHST11 RUNX2 ALPL FGFR3 FGFR1 MMP9 BMP7 GH1 ACAN SPP1 COL10A1 ADAMTS4 SOX9 ADAMTS5 ENPP1 TIMP3 HMGCS1 NKX3-2 KIF3A SOX5 CAB39 CST5 VEGFA COL2A1 SCIN DDR2 SCFA AND SKELETAL MUSCLE SUBSTRATE METABOLISM%WIKIPATHWAYS_20260510%WP4030%HOMO SAPIENS SCFA and skeletal muscle substrate metabolism GCG SLC2A4 PYY FFAR3 NR1C2 FFAR2 MICROTUBULE CYTOSKELETON REGULATION%WIKIPATHWAYS_20260510%WP2038%HOMO SAPIENS Microtubule cytoskeleton regulation EPHB2 STAT3 TRIO TIAM1 APC F2RL2 MAPKAPK2 PARD6A SPRED1 PTEN RHO MARK1 CAMK4 NTRK3 WNT3A ROCK1 RAC1 CDC2 CDC42 PAK1 CFL2 LIMK1 GSK3B DVL1 SRC PRKCA AURKB FREP1 CLASP1 TAOK1 MAP1B MAPRE1 NTRK1 PHLDB2 NTRK2 POLYOL PATHWAY%WIKIPATHWAYS_20260510%WP690%HOMO SAPIENS Polyol pathway ALDOB KHK SORD AKR1B1 FTO OBESITY VARIANT MECHANISM%WIKIPATHWAYS_20260510%WP3407%HOMO SAPIENS FTO obesity variant mechanism PRDM16 UCP1 IRX5 ARID5B TBX1 PPARGC1A IRX3 GLYCEROL METABOLISM INCLUDING LINKED IMDS%WIKIPATHWAYS_20260510%WP5570%HOMO SAPIENS Glycerol metabolism including linked IMDs GLYCTK HEL-S-49 PC PKLR AQP7 GPD2 GPD1 PCK1 LIPE PGAM1 MGLL PFKL ALDOB PNPLA2 HEL-S-165mP HEL-S-87p AGXT G6PC1 ENO1 KHK HEL-S-68p FBP1 HEL-S-162eP DIRECT REVERSAL REPAIR%WIKIPATHWAYS_20260510%WP4931%HOMO SAPIENS Direct reversal repair ALKBH3 ALKBH2 MGMT DDX1 AS A REGULATORY COMPONENT OF THE DROSHA MICROPROCESSOR%WIKIPATHWAYS_20260510%WP2942%HOMO SAPIENS DDX1 as a regulatory component of the Drosha microprocessor MRE11A NBN DGCR8 DROSHA ATM DDX1 RAD50 FACTORS AND PATHWAYS AFFECTING INSULIN LIKE GROWTH FACTOR IGF1 AKT SIGNALING%WIKIPATHWAYS_20260510%WP3850%HOMO SAPIENS Factors and pathways affecting insulin like growth factor IGF1 Akt signaling ACVR2B ITGB1 WASL MTOR TRIM63 FBXO32 GDF8 PTEN HEL-S-28 IGF1R RPTOR RPS6KB1 DEPTOR PRKAB1 SMAD2 IGFBP5 TNLG5A NFKB1 MAP1LC3A MLST8 EIF2B2 AKT1S1 MAPKAP1 RICTOR GSK3B EIF4E IRS1 TNFRSF1A IGF1 PPARGC1A GNAQ P R183Q DRIVES CAPILLARY MALFORMATION%WIKIPATHWAYS_20260510%WP5501%HOMO SAPIENS GNAQ p R183Q drives capillary malformation PPP3R1 PRKD1 PRKD2 ANGPT2 PRKCZ PKN3 PKN2 PKN1 NFATC1 PRKCH PLCB3 PRKCB PPP3R2 PRKCE PRKCA PPP3CC PRKCI PPP3CA PRKD3 PRKCQ SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260510%WP4658%HOMO SAPIENS Small cell lung cancer LAMA4 LAMA3 APAF1 RARB LAMB3 SKP1 BIRC7 LAMB2 LAMB4 CASP8 RELA LAMB1 CCNE2 BCL2L1 CKS2 CDKN1A PTEN PIK3CD CCND1 MYC AKT3 CYCS CDK2 BCL2 CDKN1C RXRA PIK3CA RB1 ITGA6 LAMC1 ITGAV FHIT CDKN2B ITGA2B NFKBIB ITGB1 LAMA5 MAX NOS2 COL4A2 CDK6 CDK4 TRAF1 IKBKB TRAF4 BIRC3 NFKBIA CHUK TRAF6 IKBKG POLK ITGA2 NFKB1 DDB2 PIK3R3 PIK3R2 TRAF2 PIK3R1 TRAF5 TRAF3 E2F2 BIRC2 E2F3 BAK1 GADD45B COL4A1 PTGS2 COL4A4 GADD45A COL4A3 COL4A6 GADD45G COL4A5 BAX CASP9 CDKN1B CCNE1 LAMC2 CASP3 CKS1B RXRB RXRG LAMA1 BIOSYNTHESIS AND TURNOVER OF 1 DEOXY SPHINGOID BASES%WIKIPATHWAYS_20260510%WP5179%HOMO SAPIENS Biosynthesis and turnover of 1 deoxy sphingoid bases SPHK1 SPHK2 KDSR SGPP2 SGPP1 SPTLC2 SPTLC1 ROBO4 AND VEGF SIGNALING CROSSTALK%WIKIPATHWAYS_20260510%WP3943%HOMO SAPIENS ROBO4 and VEGF signaling crosstalk VEGFA SRC SLIT2 RAC1 KDR ROBO4 OXIDATIVE DAMAGE RESPONSE%WIKIPATHWAYS_20260510%WP3941%HOMO SAPIENS Oxidative damage response C1R APAF1 MAPK10 C5AR1 C4B_2 C2 CDKN1A BAG4 NFKBIE TNK2 TRAF1 MAP3K1 TRAF6 NFKB1 CYCS MAPK13 C1QC CDC42 BCL2 TNF C3AR1 CDKN1C TRAF2 CR2 TRAF3 BAK1 BAD GADD45A MAP2K4 TNFRSF1B C1QA CASP9 PCNA CDKN1B CASP3 C1QB C1S DUAL HIJACK MODEL OF VIF IN HIV INFECTION%WIKIPATHWAYS_20260510%WP3300%HOMO SAPIENS Dual hijack model of Vif in HIV infection CBFB RUNX1 APOBEC3G CUL5 UBB ELOC RBX1 MFAP5 MEDIATED OVARIAN CANCER CELL MOTILITY AND INVASIVENESS%WIKIPATHWAYS_20260510%WP3301%HOMO SAPIENS MFAP5 mediated ovarian cancer cell motility and invasiveness JUN CREB1 MAPK3 TNNC1 ITGB3 MAPK1 MFAP5 RYR3 ITGAV PRKCQ PLCG1 GLYCOGEN SYNTHESIS AND DEGRADATION%WIKIPATHWAYS_20260510%WP500%HOMO SAPIENS Glycogen synthesis and degradation GYS1 HK3 PPP2R5E GSK3A PPP2R5C PTPA GYS2 PYGB PYGL PPP2R2A GYG1 PYGM PPP2R1B PPP2R1A AGL PPP2R5B PPP2R5A PPP2R5D PPP2R3B PHKB PHKA1 PPP2CA PPP2R3A CALM1 PHKA2 PPP2R2C PPP2R2B GSK3B PHKG2 HK2 LINOLEIC ACID METABOLISM AFFECTED BY SARS COV 2%WIKIPATHWAYS_20260510%WP4853%HOMO SAPIENS Linoleic acid metabolism affected by SARS CoV 2 ACE2 FADS2 FADS1 ELOVL5 ELOVL2 MRNA PROTEIN AND METABOLITE INDUCED STRESS PATHWAY BY CYCLOSPORIN A%WIKIPATHWAYS_20260510%WP3953%HOMO SAPIENS mRNA protein and metabolite induced stress pathway by cyclosporin A SLC3A2 NFE2L2 SLC7A11 SLC7A5 ATF4 KEAP1 SOMITOGENESIS IN THE CONTEXT OF SPONDYLOCOSTAL DYSOSTOSIS%WIKIPATHWAYS_20260510%WP4785%HOMO SAPIENS Somitogenesis in the context of spondylocostal dysostosis DLL3 MESP2 LFNG HES7 RIPPLY2 TBX6 EPHA4 NOTCH1 MBDNF AND PROBDNF REGULATION OF GABA NEUROTRANSMISSION%WIKIPATHWAYS_20260510%WP4829%HOMO SAPIENS mBDNF and proBDNF regulation of GABA neurotransmission GABRA3 CREB1 STAT3 PLCG1 PTEN GABRG3 GABRG2 ROCK1 GABRG1 ARHA CREM PIK3R3 PIK3R2 BDNF PIK3R1 GABRB3 GABRB2 GABRB1 AP2A1 AP2A2 PIK3CA SHC1 GABRE GABRQ GABRA2 GABRP SLC12A5 GABRA6 GABRA5 NGFR NTRK2 GABRA4 NEOLACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260510%WP5302%HOMO SAPIENS Neolacto series sphingolipid metabolism B4GALT1 FUT2 B3GNT5 SIAT4C FUT1 B4GALT4 NEU2 FUT5 FUCA1 NAGA BURN WOUND HEALING%WIKIPATHWAYS_20260510%WP5055%HOMO SAPIENS Burn wound healing TLR4 S100A6 TIMP1 IL15 CD3E CXCR4 FBN1 PECAM1 CHRNA7 CCL2 BCL2 CXCL12 MYD88 DCN COL1A2 FST ACHE FOXE1 HEXD TNC F13A1 DKFZp686P11128 MMP28 KRT222 PCTK1 FLG BRD4 AMBP HEL-S-43 S100A9 SLURP1 SCEL LIN28A TPT1 EGF HMGB1 HGF KRT6A INHBA FGFR4 FGFR3 FGFR2 KLF4 FGFR1 IL1B CXCL1 MMP2 NFKB1 MMP9 IFNA2 TNF IL6 IL8RB IFNB1 CXCL8 COL1A1 BAX VEGFA CASP3 ACTA1 SNAI2 NOX4 17Q12 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP5287%HOMO SAPIENS 17q12 copy number variation syndrome STAC2 PEX12 TCAP CDK12 SPMAP1 TEC ACACA CCL8 CCL7 CCL5 CCL4 CCL3 STARD3 CCL2 PPP1R1B PIP4K2B RFFL MMP28 LHX1 TCF2 PNMT DHRS11 PGAP3 TBC1D3B CCL4L2 TBC1D3E TBC1D3C CWC25 PIGW TBC1D3I AATF IKZF3 CCL11 CISD3 DUSP14 TBC1D3H CCT6B RDM1 CCL1 ARL5C C17orf50 GPR179 CCL15 UNC45B MED1 SLC35G3 RPL23 SRCIN1 FNDC8 SLFN12 SLFN13 RAD51D TBC1D3 SLFN11 SLFN14 ZNF830 CCL14 SLFN5 CCL13 GGNBP2 CCL3L3 FBXO47 MRM1 MLLT6 FBXL20 NEUROD2 MIEN1 ZNHIT3 LYZB C17orf78 ASIC2 CCL18 GAS2L2 SOCS7 CCL16 HEATR9 TAF15 TMEM132E CACNB1 RASL10B PCGF2 SYNRG EPOP PLXDC1 NLE1 ARHGAP23 GRB7 ERBB2 TBC1D3K NRP1 TRIGGERED SIGNALING IN PANCREATIC CANCER %WIKIPATHWAYS_20260510%WP5144%HOMO SAPIENS NRP1 triggered signaling in pancreatic cancer EGF NRP1 SEMA3A TGFBR3 RELA PLXNA1 HGF PLXNA4 CCNE2 REL GSK3A FLT1 MAPK3 SNAI1 CHD2 MAPK1 SMAD2 RAC1 SMAD4 AKT3 MMP2 KDR NFKB1 MMP9 TGFBR1 PECAM1 MAP2K2 CDK2 TGFBR2 RELB CTGF COL1A2 MET COL1A1 VEGFA NFKB2 SRC CDKN1B PLXNA2 CCNE1 EGFR MAP2K1 SNAI2 SELENIUM MICRONUTRIENT NETWORK%WIKIPATHWAYS_20260510%WP15%HOMO SAPIENS Selenium micronutrient network SELS RELA HEL-S-97n KYNU KMO PRDX3 PRDX5 HEL-S-2a ALOX5AP PLAT HEL-S-302 CRP IFNG CCL2 SCARB1 HEL-S-44 LDLR HBB HBA2 ALOX15B MPO ALOX5 XDH APOB SERPINA3 FLAD1 FGA F7 SAA4 PLG INSR CBS MTR HEL-S-78p ALB SAA1 SAA2 IL1B TXN F2 NFKB1 ABCA1 TNF SELENOF SELENOK SELENOI GPX4 SELENOH IL6 SEPHS2 GPX2 GPX1 PTGS2 PTGS1 TXNRD3 GPX3 TXNRD2 GPX6 DIO1 NFKB2 SELENOO SELENON HEL-75 SELENOM CTH SELENOP SELENOW INS SELENOV SELENOT MSRB1 NIFEDIPINE ACTIVITY%WIKIPATHWAYS_20260510%WP259%HOMO SAPIENS Nifedipine activity PCNA PTK2B HEL-S-44 MAPK1 CYP3A4 MAP2K1 BDKRB2 KDR JAK STAT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260510%WP5528%HOMO SAPIENS JAK STAT signaling and ARTD family members HDAC3 DTX3L BTRC STAT3 PARP14 HDAC2 STAT1 SKP1 RBX1 PARP1 PARP11 PATHOPHYSIOLOGICAL ROLES OF DUX4 IN FSHD1%WIKIPATHWAYS_20260510%WP5342%HOMO SAPIENS Pathophysiological roles of DUX4 in FSHD1 EP300 TRIM63 ADRB2 FBXO32 MYOG CDKN1A RET VEGFA H3Y1 H3Y2 MYOD1 DUX4 NR3A2 PAX7 MYF5 MYC PPARGC1A GENE REGULATORY NETWORK MODELING SOMITOGENESIS %WIKIPATHWAYS_20260510%WP2854%HOMO SAPIENS Gene regulatory network modeling somitogenesis HES1 FGF8 MESP2 LFNG HES7 RIPPLY2 WNT3A TBX6 EPHA4 NOTCH1 RAS SIGNALING%WIKIPATHWAYS_20260510%WP4223%HOMO SAPIENS Ras signaling RASGRF1 TIAM1 RELA MAPK9 MAPK8 SHOC2 PLCG2 PLCG1 MAPK3 ARF6 PLA2G6 PLCE1 ARHA PRKACG KSR2 PIK3CA STK4 ETS2 RAC3 FOXO4 RRAS2 IKBKB CHUK RRAS MAPK1 IKBKG RAF1 NFKB1 CDC42 RALBP1 RAP1A SYNGAP1 RASGRP4 PRKCB PLD2 RASGRP3 PRKCA GRIN2B GRIN1 RALA RALB ZAP70 RAB5B GAB2 TNFSF6 EXOC2 BCL2L1 GNG12 GNG11 FLT1 GNG13 FLT3 FLT4 RAB5A PIK3CD IGF1R RIN1 PLA1A GNB2 HTR7 PLA2G3 AKT3 RASAL1 GNB1 KDR RASAL3 TTBK1 GNB4 AFDN GNB3 HRAS GNB5 RASGRF2 PDGFRA PLA2G12A MAP2K2 CALM1 PLA2G4F RASA4B KSR1 PLA2G12B PLA2G4D PLA2G4E PLA2G4B PLA2G4C PLAAT3 RASA3 GNGT1 RASA4 KIT RASA2 RAPGEF5 SOS1 PLA2G1B SOS2 PLA2G2F MET PLA2G2D EPHA2 PLA2G2E CSF1R PLA2G5 PLA2G2C SHC1 LAT EGFR SHC4 SHC3 NTRK1 NGFR NTRK2 PAK6 ABL2 INSR PAK4 GNG3 MAPK10 GNG2 GNG5 GNG4 PLA2G2A REL GNG7 KRAS GRB2 GNG8 FGFR4 FGFR3 FGFR2 FGFR1 CALML6 PLA2G10 GNGT2 CALML3 CALML4 RASSF1 RAC1 SHC2 PIK3R3 PIK3R2 PIK3R1 RAB5C NRAS PAK1 GNG10 BAD PTPN11 NF1 MAP2K1 MIR TARGETED GENES IN MUSCLE CELL%WIKIPATHWAYS_20260510%WP2005%HOMO SAPIENS miR targeted genes in muscle cell GPD2 CSF1 PKN2 POLE4 POLA2 CBFB MAPK14 IGF2R FGF2 BCL2 CTNNB1 TNFRSF10B LPL DNAJB1 FADS2 RAB27B PICALM HEL-S-30 MBNL1 GNA13 HYAL3 GRIA2 BACE1 NRP1 CDKN1A CCND1 PPP3CA PPP1R7 SH3BP4 SDCBP CXCL12 KIT MET CPNE8 NCL VEZT TMEM41B BACH1 PWP1 CSNK1D RAVER2 EGFR CIAO2A SEC62 HEL-S-303 CACNA2D1 FNDC3B FNDC3A MTRR CARHSP1 HEL-S-273 WDR82 FAR1 TMEM87A HACD3 UBE2J1 COMMD9 GRPEL2 ATP6V1C1 MOV10 RHEB NCEH1 PDE3A STRN KRAS ANP32B GFM1 MAGT1 PANX1 PTPRF COIL SERP1 RDH10 C1QBP GNPNAT1 TUSC2 MAPK7 TMED7 ARID4B MRPS24 IGF2BP1 ELMOD2 TXN2 TMT1A CHORDC1 AP3B1 PDLIM7 VSNL1 CDK5RAP3 CSDE1 ARHG THBS1 VPS39 PXDN ATP6V0E1 AMIGO2 FSTL1 ITGA2 IFRD1 NAPG NT5E HEL-S-66 PISD MPZL1 RNP24 SPRYD4 RAB34 TTC9C PPIF TPPP3 GPAM NFIA NEDD4 SLC1A4 SNX15 ADIPOR2 LAMTOR5 RTN4 LTN1 CORO1C E2F3 MRPL20 CPOX ABHD10 POGLUT3 KPNA3 SNX6 SLC38A1 RARS1 CD164 TPM1 STX7 BRPF3 UBE4A TBCA CDKAL1 ITGB4 SFXN1 RAB30 CDKN1B SYPL1 SLC25A1 ARF4 PTMAP7 SLC12A2 TRAM1 GEMIN7 SRSF9 ABCG2 TMED10 RAI14 TNFAIP2 CAMTA1 ADAR SLC38A5 LMNB2 TM6SF1 GFPT1 SNAP23 MRC2 SLC4A10 TMEM43 SPCS3 GNL3L TMED3 CHMP2A SRPRB TMEM109 CYP51A1 SH3BGRL3 DKFZp761E1322 POLD2 CALCOCO2 ACP2 NELFCD DOCK7 CTSC CYR61 SYNE2 SCYL1 SLC7A6 SYNE1 CDCP1 HEL-S-108 HSDL1 RFT1 FRG1 RCN2 RBMS1 DSG2 ANAPC1 SEC23A HEL-S-47e PTPA LUZP1 CYP1B1 SHOC2 NUFIP2 NXN CDIPT CA12 HSD17B12 AP3D1 ACVR1B HES1 ARCN1 ATG9A CAND1 WDR11 TDG TP53INP1 FMNL2 ZNF622 SLC25A24 GALNT7 NHERF2 GALNT1 SLC4A7 SLC25A32 PLK1 BET1 SPTLC1 DHX15 USP1 RB1 MTHFD2 SRSF10 GSTM4 LAMC1 CLDN1 TPM3 ARID1A EHMT1 CDK6 TYMS EZH2 LAMTOR3 PGRMC1 POLR2C CEBPB GJA1 DOCK5 COL1A1 COL3A1 SNAP29 LAMC2 IRS1 ASH2L ERBB2 MCL1 MAPK12 SLC7A11 HMOX1 SSNA1 SLC25A13 CUL4B AXL MYLIP ATP2A2 RQCD1 YWHAQ COL1A2 P4HA2 PPIB MYO1E SPARC ERBB3 HMGA1 ERG PSAT1 CCNG1 TGFBR2 NOTCH2 NOTCH1 NF2 EIF4E PRKCI PHLDB2 UHRF1 CARDIOMYOCYTE SIGNALING CONVERGING ON TITIN%WIKIPATHWAYS_20260510%WP5344%HOMO SAPIENS Cardiomyocyte signaling converging on titin TCAP ADRB1 TRIM63 ADRB2 MDM2 ANKRD2 MAPK1 RAF1 GUCY1B1 FHL1 MYPN TTN CSRP3 NUP62 MAP2K2 ANKRD1 HEL-S-101 ANKRD23 PRKACG C22orf13 NBR1 TRIM55 FHL2 PRKCA CAMK2A MAP2K1 PRKAR1A GALANIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260510%WP4970%HOMO SAPIENS Galanin receptor pathway CREB1 YAP1 SLC2A4 CDKN1C VAMP2 IL6 BCL2L11 PPARG CDKN1A CRP VEGFA CDKN1B POMC INS FOS RETINOID METABOLISM IN RETINA HEALTHY VS RLBP1 DEFICIENT%WIKIPATHWAYS_20260510%WP5532%HOMO SAPIENS Retinoid metabolism in retina healthy vs RLBP1 deficient RLBP1 OVARIAN INFERTILITY%WIKIPATHWAYS_20260510%WP34%HOMO SAPIENS Ovarian infertility NCOR1 CREB1 FIGLA EGR1 SYNE2 MTOR NR5A1 FMR1 FSHR DMC1 ZP3 CDK4 TBP NR3A2 PGR PRLR NR1i1 CEBPB TSC2 TSC1 LHCGR INHA ZP2 GJA4 DAZL PTGER2 GDF9 CDKN1B ATM CCND2 SMPD1 RAD51 PSORIASIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260510%WP5537%HOMO SAPIENS Psoriasis mechanism and therapies STAT3 TNF IL23A CCR6 HLA-C IL17RC IL12B IF2B1 CXCL8 IL23R IL1B IL17F IL17A CXCL1 CCL20 TYK2 IL12RB1 BASE EXCISION REPAIR%WIKIPATHWAYS_20260510%WP4752%HOMO SAPIENS Base excision repair POLD2 PARP3 HMGB1 PARP2 APTX POLE RFC3 RFC4 LIG1 RFC1 POLE4 RFC2 POLD3 TDG POLE3 FEN1 POLE2 MPG OGG1 PNKP APEX1 UNG NTHL1 POLL MUTYH TDP1 MBD4 PCNA PARP4 ADPRHL2 SMUG1 NEIL3 NEIL2 POLG2 NEIL1 PARP1 POLD4 POLG HIPPO MERLIN SIGNALING DYSREGULATION%WIKIPATHWAYS_20260510%WP4541%HOMO SAPIENS Hippo Merlin signaling dysregulation YAP1 AMOT CDH11 RBX1 PPP1R14A HEL-S-80p FLT1 FLT3 ITGA4 CUL4A FLT4 DDB1 IGF1R CCND1 MYC FOXM1 KDR HRAS PDGFRA WWTR1 CTNNB1 PRKACG PLCB4 ITGB6 KIT TEAD4 MET EPHA2 CSF1R ITGB3 EGFR ITGA6 ITGB5 ITGAE ITGAV NTRK1 DCAF1 NGFR PPP1CC NTRK2 ITGB8 PAK6 ITGA7 ITGA2B PAK4 INSR CDH2 ITGB1 KRAS TEAD2 FGFR4 TEAD3 FGFR3 ITGA1 FGFR2 CD44 FGFR1 VGLL4 ITGAM CDH17 CDH9 ITGA2 ITGB7 CDH8 CDH6 CDH4 ITGAX CTNNA1 NRAS CTGF PAK1 AJUBA CDH24 LIN28B NF2 ITGB4 LATS1 LATS2 CDH10 CDH12 PRKAR1B CDH15 CDH16 PRKAR1A CDH18 CDH19 BARDET BIEDL SYNDROME%WIKIPATHWAYS_20260510%WP5234%HOMO SAPIENS Bardet Biedl syndrome TTC8 MKS1 IFT27 EFHC2 CLUAP1 INVS CEP164 FLCN DYNC2I2 TRAF3IP1 IFT172 GLI3 IFT52 TMEM107 ZIC2 CNGA1 NEK1 BBS9 BBS7 SCAPER CFAP418 CFAP410 PKD1 IFT57 RP2 MAK EFHC1 PTCH1 BBS5 CNGB1 BBS4 SDCCAG8 DYNC2H1 CRX PKD1L1 PKHD1 IFT140 SMO PDE6D NPHP3 USP9X IFT80 PCARE GPR161 DCDC2 WDR35 CEP41 LZTFL1 TRIM32 BBS10 IFT43 OCRL EVC NEK8 BBS12 IFT81 TMEM216 WDPCP BBIP1 SUFU CEP104 KIF7 ARL6 ARL3 DYNLT2B DYNC2LI1 IFT74 ARL13B TMEM67 RAB23 INPP5E CEP290 IQCB1 EVC2 BBS2 BBS1 SCLT1 FUZ GENES CONTROLLING NEPHROGENESIS%WIKIPATHWAYS_20260510%WP4823%HOMO SAPIENS Genes controlling nephrogenesis ITGB1 LAMB2 SLIT2 SHH ETV4 FGFR2 HEL-S-28 KIRREL1 MAFB CXCR4 KDR CD36 WT1 CTNNB1 FGF8 TCF21 PAX2 CXCL12 EMX2 NOTCH2 LMX1B NCK2 NCK1 CD2AP RET WNT4 FOXD1 VEGFA NPHS1 ROBO2 NPHS2 FOXC2 FOXC1 HOXD11 SIX1 GDNF HOXA11 GLI3 EYA1 LHX1 TCF2 DEVELOPMENT AND HETEROGENEITY OF THE ILC FAMILY%WIKIPATHWAYS_20260510%WP3893%HOMO SAPIENS Development and heterogeneity of the ILC family ZBTB16 IL7 IL9 HNF1A IL13 IL12B IF2B1 IL12A IL15 RORC IL1B RORA AHR ID2 GFI1 ATL1 IL33 TSLP TOX IL18 IFNG TNF IL23A IL25 IL6 GATA3 NFIL3 AREG TBX21 IL4 IL17A IL5 CANNABINOID RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP3869%HOMO SAPIENS Cannabinoid receptor signaling MAPK12 MAPK10 MAPK11 MAPK9 MAPK8 MAPK3 DAGLA AHR CNR1 MAPK1 MAPK14 CYP1A1 MAPK13 NAPEPLD DAGLB FAAH PRKACG CYP3A4 CYP2C19 CYP2C9 ADORA2A CNR2 PRKAR1B PRKAR1A ADCY1 COHESIN COMPLEX CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260510%WP5117%HOMO SAPIENS Cohesin complex Cornelia de Lange syndrome APC PPP2R5E PPP2R5C PTPA RAD21 PPP2R1B PPP2R1A NIPBL PLK1 PPP2R5B PPP2R5A PPP2R5D CDC2 CDCA5 PDS5B STAG2 PDS5A PPP2CA HDAC8 SGOL1 WAPAL ESCO1 ESCO2 SMC1A REC8 SMC1B MAU2 ESPL1 STAG3 AURKB SMC3 PTTG1 OMEGA 3 OMEGA 6 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260510%WP4723%HOMO SAPIENS Omega 3 omega 6 fatty acid synthesis PLA2G5 FACL4 ACSL3 FADS2 ACOX3 PLA2G4B FADS1 ACOX1 PLA2G6 ELOVL5 ACSL1 ELOVL2 FAMILIAL HYPERLIPIDEMIA TYPE 4%WIKIPATHWAYS_20260510%WP5111%HOMO SAPIENS Familial hyperlipidemia type 4 APOA5 GCK LIPC LPL PDIA2 APOA4 SEL1L PLTP LMF1 LDLR ACSS1 GPIHBP1 MTTP DGAT2 GCKR APOA2 FAS APOC2 NOD LIKE RECEPTOR NLR SIGNALING%WIKIPATHWAYS_20260510%WP288%HOMO SAPIENS Nod like receptor NLR signaling EPHB2 IKBKB MAP3K7 ERBIN CHUK RELA IKBKG MAPK8 CD40 LIPID METABOLISM IN SENESCENT CELLS%WIKIPATHWAYS_20260510%WP5149%HOMO SAPIENS Lipid metabolism in senescent cells PLA2G12A PLA2G4F PLA2G12B PLA2G4D PLA2G4E PLA2G4C PTGS2 PLA2G1B CDKN1A PLA2G2D SLCO2A1 PLA2G5 PLA2G10 ALOX5 PLA2G3 PLA2G6 PLA2G7 HRAS HUNGER AND SATIETY%WIKIPATHWAYS_20260510%WP5445%HOMO SAPIENS Hunger and satiety MC4R NPY GCG AgRP PYY GHRL POMC LEP TGFB SMAD SIGNALING%WIKIPATHWAYS_20260510%WP5382%HOMO SAPIENS TGFB Smad signaling WWTR1 POSTN TGFBR2 TGFBR3 CTGF SMAD2 SMAD4 SPARC YWHAG TGFBR1 LUNG PATHOLOGY OF COVID 19%WIKIPATHWAYS_20260510%WP5146%HOMO SAPIENS Lung pathology of COVID 19 MITA CCL2 TNF CSF2 IRF3 MAVS IL6 TLR7 CXCL11 TLR3 RIGI IL1B CXCL9 TLR8 CGAS NFKB1 IL18 IFIH1 TBK1 OXIDATIVE STRESS RESPONSE%WIKIPATHWAYS_20260510%WP408%HOMO SAPIENS Oxidative stress response MAPK10 HMOX1 MGST1 UGT1A3 TXN2 CYBB NQO1 MAPK14 CYP1A1 NFKB1 SP1 MAOA HEL-S-44 GPX1 GPX3 TXNRD2 GSTT2 XDH NOX3 NFE2L2 NOX5 JUNB HEL-75 GCLC FOS NOX4 NEUROINFLAMMATION AND GLUTAMATERGIC SIGNALING%WIKIPATHWAYS_20260510%WP5083%HOMO SAPIENS Neuroinflammation and glutamatergic signaling CREB1 GLS IL1R1 IL12B SHMT1 IL1A MAPK3 IL12A TGFB1 DLD SMAD2 SMAD4 IL10RB IL10RA FGF2 BCL2 PLCB4 PIG59 TNFRSF1B HEL-S-15 GRIN3B GRIN3A PDHA1 IGF1 PPP1CC SLC1A3 DLAT TGFBR3 ARC GLS2 MAPK1 NFKB1 TRAF5 IL13RA1 GRIA2 NGF PRKCB PRKCA CNTF GRIN2B IRS1 IL1R2 TNFRSF1A GRIN1 SLC1A1 SLC1A2 NELF SLC38A3 GRIA4 DAO SLC6A9 GRIK5 GRIK3 GRIK1 LTA LRRC8C LRRC8D SLC17A6 SLC17A7 LRRC8E IL13 HEL-S-80p IL10 PLCB1 JAK1 GRM2 STAT1 IL6ST GRM4 GRM8 IFNGR1 IL6R TGFBR1 CALM1 IFNG DISC1 SOCS3 LIF IL4 PLCB3 GFAP CAMK2D CAMK2A ADCY3 ADCY1 ADCY8 INSR STAT3 SRR GRIA3 PSAT1 PHGDH HEL-S-51e PSPH CAMK2G GRIK2 IL1B CAMK4 CAMKK1 PLCB2 CAMKK2 SLC7A10 TNF BDNF TGFBR2 SLC1A4 IL6 SLC2A3 SLC38A1 NFKB2 IFNGR2 SLC38A5 FOS ETHER LIPID BIOSYNTHESIS%WIKIPATHWAYS_20260510%WP5275%HOMO SAPIENS Ether lipid biosynthesis FAR1 UGT8 PEX16 LPCAT1 PEDS1 ALDH3A2 GNPAT PEX7 PEX5L DHRS7B AGMO CEPT1 AGPS ACAD10 LPIN2 PEX3 LPIN3 PEX19 LPIN1 AUTOPHAGY IN PANCREATIC DUCTAL ADENOCARCINOMA%WIKIPATHWAYS_20260510%WP5331%HOMO SAPIENS Autophagy in pancreatic ductal adenocarcinoma STAT3 HMGB1 PARK2 MDM2 KRAS PINK1 VMP1 SHOC2 SQSTM1 IPO8 DKFZp762B153 NFE2L2 AGER NFKB1 TFEB PARTHANATOS CELL DEATH SIGNALING PATHWAY%WIKIPATHWAYS_20260510%WP5585%HOMO SAPIENS Parthanatos cell death signaling pathway AIFM1 PARP1 MIF EFFECT OF PROGERIN ON GENES INVOLVED IN PROGERIA%WIKIPATHWAYS_20260510%WP4320%HOMO SAPIENS Effect of progerin on genes involved in progeria MTA3 MBD3 SUV39H1 H3F3B H3C15 MBD2 CHD4 HDAC2 LEF1 RBBP7 HDAC1 HEL25 KDM1A CBX1 RB1 CHD3 CBX3 RBBP4 MTA2 H3C8 GABA RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP4159%HOMO SAPIENS GABA receptor signaling GABRA3 ABAT GABBR2 GABBR1 SLC6A1 GABRG3 AP2S1 AP2M1 GABRG2 SLC32A1 GABRG1 GAD1 GAD2 SLC6A11 ALDH9A1 GPHN GABRB3 GABRB2 GABRB1 AP2A1 AP2A2 GABRE GABRQ GABRA2 GABRP GABRA6 GABRA5 GABRA4 ULTRACONSERVED REGION 339 MODULATION OF TUMOR SUPPRESSOR MICRORNAS IN CANCER%WIKIPATHWAYS_20260510%WP4284%HOMO SAPIENS Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer CCNE2 GLYCEROLIPIDS AND GLYCEROPHOSPHOLIPIDS%WIKIPATHWAYS_20260510%WP4722%HOMO SAPIENS Glycerolipids and glycerophospholipids CRLS1 DGKZ AGPAT4 GPAM GPAT4 DGAT1 PEMT PNPLA3 PTDSS2 PTDSS1 CHKB PLA2G1B PCYT2 CDIPT ETNK1 DGAT2 PNPLA2 CDS1 PISD FOXP3 IN COVID 19%WIKIPATHWAYS_20260510%WP5063%HOMO SAPIENS FOXP3 in COVID 19 IL2RA STAT5B STAT3 IL6 IL7R CD80 IL6ST IL2RG IL2RB IL2 FOXP3 IL6R EBOLA VIRUS INFECTION IN HOST%WIKIPATHWAYS_20260510%WP4217%HOMO SAPIENS Ebola virus infection in host EP300 TLR4 TIAM1 RELA MAPK3 TFAP2A ARHA ACTG1 ACTN1 IQGAP1 PIK3CA HLA-A HLA-DRB1 FLNA HLA-B PS1TP5BP1 HLA-C HLA-F HLA-E ITGA1 MAPK1 NFKB1 HAVCR2 CDC42 MBL2 RELB TYRO3 MFGE8 ADAM17 RFC1 ITGA4 CREBBP RAB5A VPS4A HLA-G PIK3CD STAT1 IGF1R HLA-DRA MERTK AXL CLEC4M HLA-DMB CLEC10A ICAM2 NPC1 ICAM3 HLA-DOA SOCS3 NPC2 HLA-DOB HLA-DMA KPNA1 VPS18 CLTC RASA2 CD300A VPS33A ACTN4 CLTB TIMD4 TSG101 IL4 CLTA CLTCL1 VPS11 RAB7A HLA-DQA2 HLA-DQA1 VPS16 HLA-DRB5 CAV3 CAV2 ITGB3 EGFR BST2 CD209 ITGA6 CLEC6A EIF2AK2 ASGR1 ITGAV HAVCR1 HLA-DPA1 HLA-DQB2 TBK1 HLA-DQB1 CTSL FLNB IKBKE DAB2IP PRKRA IRF3 VPS41 ITGB1 IRF7 HLA-DPB1 RAB9A RIGI REL FOLR1 EIF2S1 VAV2 C1QBP VPS39 RAC1 ITGA2 RHOB PIK3R3 PIK3R2 PIK3R1 PAK1 NEDD4 SCIN NFKB2 CAMKK2 PATHWAY%WIKIPATHWAYS_20260510%WP4874%HOMO SAPIENS CAMKK2 pathway CREB1 EP300 RELA ACACA HMOX1 SLCO3A1 MAPK3 IL15 ULK1 RPS6 DKFZp762B153 RPTOR RPS6KB1 CCND1 PCK2 KDR MAP1LC3A CCL5 EPOR CALM1 VCAM1 TSC1 SMC1A CXCL11 HIF1A SELL AQP1 CRTC2 FIS1 FASN HK2 TSPAN8 NFATC2 GCK MTOR MS4A3 HFE IFGGE IFI44L OASL ERMAP GALNT9 MAMDC2 MID1 FAM20C ERAF STIM1 SPINT1 SQSTM1 HMBS SFI1 WDR35 S100A8 PFKFB2 CAMK4 ATP10D DGIC TBXT ARHGEF7 TSPAN33 MAPK1 CAMK1 RHD RAC1 RAF1 ENHO CAMKK2 CYB5R3 SLC25A21 NLRP1 WFS1 CHRM3 KEAP1 MX2 ASNS ABCA1 LR8 SLC2A4 TNF TRPV4 SPIRE1 RHAG PAK1 SIRT1 C1QTNF12 CPOX CCNE1 NFE2L2 ATP1B2 SLC38A5 KLF1 PARP1 MAF MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY WITH INHIBITORS%WIKIPATHWAYS_20260510%WP4189%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway with inhibitors HMGCR MVD EXERCISE INDUCED CIRCADIAN REGULATION%WIKIPATHWAYS_20260510%WP410%HOMO SAPIENS Exercise induced circadian regulation PIGF H2BC15 CBX3 HEL-S-72p NCKAP1 CEBPB DAZAP2 CRY1 BTG1 TOB1 PURA HLA-DMA STBD1 SUMO3 UCP3 PER2 QK3 ERC2 RBPMS ZFR G0S2 PER1 ETV6 CLDN5 PSMA4 AAG1 IDI1 PPP1R3C KLF9 MYF6 SUMO1 GSTM3 HEL-S-22 VAPA CRY2 NR1D2 ECTODERM DIFFERENTIATION%WIKIPATHWAYS_20260510%WP2858%HOMO SAPIENS Ectoderm differentiation ARHGAP15 ZBTB2 SOCS2 TRPM2 RHPN1 ST8SIA4 HESX1 ZBTB7B GAS2L1 GREB1 ZFHX4 PAN2 PTPRB PPFIBP2 NUMA1 SCHIP1 LDB2 TFAP2A WDR44 SIX6 RAB8B JUP BCAS3 CAP2 PAX3 PAX6 SORCS1 BAZ1A FOXL1 SMAD4 SERPINB6 CLDN11 TOX3 ARHGAP10 ARHGEF9 KIFC3 RUTBC3 STX16 RRBP1 CTNNB1 HDAC6 TBL1X CLVS1 TTC14 C1GALT1 PTPN13 VAX2 RIT1 ZNF219 MYORG ELOVL2 BMPR1A GLI3 LHX1 HMGB2 NLGN1 ELOVL4 BOC CDON SMURF1 FZD5 MAFB FZD4 TFAP2C FZD8 CTNNA2 CTNND2 DMD FHL2 TLE5 MKS1 ARHGDIG BCOR NR1C2 MYC TNFRSF11B GLB1 CCL2 SDCBP SOX2 CTBP1 NLK NFATC1 SKIL PIM1 PLXNA2 ROR2 WNT1 RGMA ZBTB16 FYN TCF7L1 KRT6A SHH TCF3 TNLG7C UBTF BMP4 FGFR2 FOXA2 SPRY2 SNCA POU2F2 CDH8 CDH6 H2BC9 NR2F2 PRKAG2 PDE7A AHI-1 NF2 OGT HDAC10 CELSR2 KCNK10 MZF1 ASTN1 LY6E ARX GATA6 STC1 RIOK1 AND RIOK2 IN EGFR AND PI3K MEDIATED TUMORIGENESIS%WIKIPATHWAYS_20260510%WP3873%HOMO SAPIENS RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis PIK3CA PTEN MTOR EGFR AKT3 MAPKAP1 RPL11 MLST8 RIOK2 RICTOR RIOK1 FOXO3A IRON METABOLISM IN PLACENTA%WIKIPATHWAYS_20260510%WP2007%HOMO SAPIENS Iron metabolism in placenta HEPHL1 TFR2 IREB2 TF SLC40A1 MCOLN1 HEL60 SLC11A2 STEAP3 HAMP TFRC SLC25A46 PATHWAY%WIKIPATHWAYS_20260510%WP5521%HOMO SAPIENS SLC25A46 pathway EMC1 EMC2 EMC3 EMC6 EMC7 OPA1 MFN1 MFN2 APOOL MMGT1 IMMT TMEM85 COX4NB EMC10 MICOS13 MICOS10 APOO CHCHD3 CHCHD6 NRF2 PATHWAY%WIKIPATHWAYS_20260510%WP2884%HOMO SAPIENS NRF2 pathway UGT1A4 TGFB1 UGT1A3 UGT1A7 SLC39A2 SLC39A1 NQO1 SLC39A3 UGT1A1 ALDH3A1 CES3 FTL DNAJB1 PTGR1 MAFG MAFF GSTM4 GSTM3 GSTM5 SLC2A2 SLC5A1 EGR1 FGF13 SLC39A9 FTH1 SLC39A6 SLC39A5 SLC39A8 SLC6A19 SLC6A18 SLC6A17 SLC6A16 SLC6A13 HSP90AB1 HEL126 SLC5A6 SLC5A7 SLC5A8 TXN SLC5A9 CES8 EPHA3 HEL-S-10 MGST3 MGST2 SLC5A2 SLC6A20 SLC5A3 SLC5A4 SLC5A5 SLC2A9 HEL-S-128m SLC6A5 SLC6A7 SERPINA1 SRXN1 SLC2A4 SLC2A6 SLC6A2 SLC2A7 SLC2A8 SLC6A8 ME1 CYP4A11 SLC2A14 GSTA4 SLC2A11 GSTA3 SLC2A10 ABCC5 SLC2A13 SLC2A12 HEL-S-25 SLC39A11 SLC39A10 SLC39A13 SLC39A12 SLC39A14 SLC5A12 SLC5A10 HEL-S-22 SLC6A9 UGT2B7 SLC7A11 HMOX1 NR1C2 SLC6A1 AGER SLC6A11 SLC6A3 RXRA ABCC3 ABCC2 UGT1A9 EPHA2 NRG1 HBEGF TGFA HGF SQSTM1 ADH7 CYP2A6 KEAP1 CES2 TGFBR2 CES1 GPX2 SLC2A3 TXNRD3 GPX3 GSTM2 GSTM1 GSTT2 NFE2L2 HEL-75 GCLC GSTA5 GCLM HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP313%HOMO SAPIENS Hepatocyte growth factor receptor signaling STAT3 ITGB1 HGF GRB2 MAPK8 MAP4K1 MAPK3 ITGA1 RAPGEF1 PTEN PTK2B MAPK1 DOCK1 RAF1 HRAS MAP2K2 PAK1 PTGS2 CRKL PTPN11 SOS1 MET PXN RAP1A JUN PIK3CA SRC CRK MAP2K1 FOS CELL LINEAGE MAP FOR NEURONAL DIFFERENTIATION%WIKIPATHWAYS_20260510%WP5417%HOMO SAPIENS Cell lineage map for neuronal differentiation SHANK1 GLS 5HT1A HES1 PAX3 PAX6 SNAP25 UNC13A CLDN11 SYP PECAM1 TH AP2A1 AP2A2 PIG59 ACHE TNC ROBO1 GATA4 LHX1 CNP SLC1A3 ERAS NLGN1 KLF4 FGF7A SLC6A5 SLC6A2 NEF3 MIXL1 SOX9 NEFL TWIST2 RIMS2 HOMER3 HOMER1 BSN GRIN2B RBFOX3 TWIST1 GRIN1 MSX2 DLG4 FBXO15 SLC1A2 CASK SHANK3 TBR1 TPH1 SNAI2 LIN7A FUT4 SLC6A9 MAP2 ChAT DLG2 HES5 FEV OLIG2 SOX10 CD24 NODAL PCLO SLC17A6 SOX17 ERC1 SLC17A7 SLC18A3 FOXD3 DPPA2 DCX GLRA1 GLRA2 GLRA3 CACNG2 HES3 KCNJ6 MOG S100B GLRB GABBR2 RIMBP2 GABBR1 SLC6A1 GAD1 GAD2 ADRA2C HTR5A ADRA2B ADRA2A SLC6A3 GPHN MSX1 CD34 AQP4 SOX2 LMX1B POU5F1 LEF1 GFAP DPPA3 ZFP42 CSPG4 ITGA6 NGFR CDH2 ITGB1 BMP4 FOXA2 SNAI1 TBXT MBP NOTCH1 TPM1 HOMER2 NR2A1 ESRRB GATA6 DISORDERS IN KETONE BODY SYNTHESIS%WIKIPATHWAYS_20260510%WP5175%HOMO SAPIENS Disorders in ketone body synthesis BDH1 OXCT1 ACAT1 HMGCL MRNA VACCINE ACTIVATION OF DENDRITIC CELL AND INDUCTION OF IFN 1%WIKIPATHWAYS_20260510%WP5187%HOMO SAPIENS mRNA vaccine activation of dendritic cell and induction of IFN 1 TNFRSF11A IRF3 MAVS IRF7 TLR8 TLR7 MR1 TLR3 RIGI IFIH1 BIOGENIC AMINE SYNTHESIS%WIKIPATHWAYS_20260510%WP550%HOMO SAPIENS Biogenic amine synthesis PNMT ChAT DDC TH MAOA HDC ASMT ACHE DBH AANAT PAH GAD1 GAD2 TPH1 GPR40 ROLE IN INSULIN SECRETION%WIKIPATHWAYS_20260510%WP3958%HOMO SAPIENS GPR40 role in insulin secretion PLCB3 PLCD3 PKD1 GNA11 PLCL1 PLCH1 PLCB2 FFAR1 PLCE1 PLCG2 PLCG1 PLCB1 GLYCOSYLPHOSPHATIDYL INOSITOL ANCHOR PATHWAY%WIKIPATHWAYS_20260510%WP5505%HOMO SAPIENS Glycosylphosphatidyl inositol anchor pathway PGAP1 PIGO PGAP2 PIGN PGAP3 GPAA1 PIGP PIGV PIGY PIGX PIGW PIGC DPM2 PIGB PIGA PIGK PIGM MPPE1 PIGL PIGH PIGF PIGS PIGU PIGT FAMILIAL HYPERLIPIDEMIA TYPE 5%WIKIPATHWAYS_20260510%WP5112%HOMO SAPIENS Familial hyperlipidemia type 5 APOA5 LIPC LPL APOA4 SEL1L PLTP APOA2 LDLR LMF1 APOC2 GPIHBP1 LNCRNA IN CANONICAL WNT SIGNALING AND COLORECTAL CANCER%WIKIPATHWAYS_20260510%WP4258%HOMO SAPIENS lncRNA in canonical Wnt signaling and colorectal cancer MACROH2A2 CSNK1A1L SOX17 CER1 CSNK2A3 CSNK2A2 CTNNBIP1 DKK2 SFRP5 CSNK2B PORCN TFAP2A HNRNPK CHD8 SOST KREMEN1 SENP2 CCND1 CXXC4 MYC NKD1 NKD2 WIF1 FOSL1 NOTUM CTNNB1 AXIN2 DKK1 CTBP1 SFRP1 NLK FRAT1 DVL1 DVL2 JUN DVL3 WNT4 TCF7L2 CDK8 LEF1 RYK AXIN1 LRP5 CSNK1E ROR1 CTBP2 ROR2 LRP6 WNT1 CSNK1A1 ATF3 TCF7L1 WNT2B CSNK2A1 FZD10 APC WNT5B WNT16 FZD1 TCF3 SFRP4 CDK6 APC2 EZH2 WNT3 WNT10B WNT10A FRAT2 FZD3 FZD2 FZD5 WNT3A WNT7B FZD7 DKK4 FZD9 WNT7A FZD8 RUVBL1 GSK3B CCND3 MAP3K7 CCND2 PLATELET MEDIATED INTERACTIONS WITH VASCULAR AND CIRCULATING CELLS%WIKIPATHWAYS_20260510%WP4462%HOMO SAPIENS Platelet mediated interactions with vascular and circulating cells CCL2 VCAM1 TLR4 TLR7 CD40 TGFB1 IL1B PF4 CD40LG SELP SELPLG CCL5 SELE PURINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260510%WP4224%HOMO SAPIENS Purine metabolism and related disorders HEL-S-70p PAICS RRM2B ADSL MOCOS AOX1 AMPD1 XDH PFAS PNP APRT TPMT DGUOK ADA IMPDH1 HPRT1 ADSS SEROTONIN RECEPTOR 2 AND ELK SRF GATA4 SIGNALING%WIKIPATHWAYS_20260510%WP732%HOMO SAPIENS Serotonin receptor 2 and ELK SRF GATA4 signaling MAP2K2 RASGRF1 HTR2A NRAS MAPKAPK2 KRAS MAPK3 HTR2B MAPK1 RAF1 MAP2K1 GATA4 HRAS PARKINSON 39 S DISEASE PATHWAY%WIKIPATHWAYS_20260510%WP2371%HOMO SAPIENS Parkinson 39 s disease pathway GPR37 UBE2G1 APAF1 UBE2G2 UBE2J1 SNCAIP MAPK12 SEPT5 HTRA2 HEL-S-67p MAPK11 EPRS1 SYT11 PARK2 CCNE2 PINK1 HEL-117 UBB SNCA MAPK14 CYCS MAPK13 SLC6A3 DDC TH CASP6 CASP2 UBE2J2 CASP9 CCNE1 CASP3 UBA7 LRRK2 UBE2L6 ATXN2 INTEGRATED CANCER PATHWAY%WIKIPATHWAYS_20260510%WP1971%HOMO SAPIENS Integrated cancer pathway CHEK1 MRE11A BBC3 CASP8 CDC25B BRCA1 MSH2 MDM2 NOXA1 MSH6 CDKN1A ATF1 JAK1 CDK4 PTEN STAT1 BARD1 BLM SMAD2 MYC PLK1 CDC2 CDK2 BCL2 ATR BAD POU2F1 BAX CASP9 CDKN1B BACH1 CASP3 ATM RB1 MAP3K5 CDKN2B RAD50 CHEK2 OSTEOCLAST SIGNALING%WIKIPATHWAYS_20260510%WP12%HOMO SAPIENS Osteoclast signaling TNFRSF11A CTSK TNFSF11 ATP6V1G1 IFNAR1 GPR68 SPP1 AIMP2 TRPV5 ACP5 MAPK8 IFNB1 ITGB3 TNFRSF11B ONCOSTATIN M SIGNALING%WIKIPATHWAYS_20260510%WP2374%HOMO SAPIENS Oncostatin M signaling CREB1 RELA JAK3 MAPK9 MAPK8 JAK1 MAPK3 STAT5B JUND STAT1 RPS6 IL6ST MAPK14 OSMR TYK2 HRAS MAP2K2 CDK2 HIF1A SOCS3 SOS1 PXN SHC1 SRC STAT3 EGR1 MTOR KRAS GRB2 NFKBIA PTK2B MAPK1 RAF1 NFKB1 CEBPB PIK3R1 OSM PTPN11 RICTOR PRKCH VEGFA PRKCB PRKCE CDKN1B PRKCA CASP3 JUNB IRS1 MAP2K1 FOS BENZENE METABOLISM%WIKIPATHWAYS_20260510%WP3891%HOMO SAPIENS Benzene metabolism MPO GSTM1 NQO1 EPHX1 DHDH CYP2E1 HFE EFFECT ON HEPCIDIN PRODUCTION%WIKIPATHWAYS_20260510%WP3924%HOMO SAPIENS Hfe effect on hepcidin production HFE HFE2 TMPRSS6 ID1 HAMP BMP6 MECHANOREGULATION AND PATHOLOGY OF YAP TAZ VIA HIPPO AND NON HIPPO MECHANISMS%WIKIPATHWAYS_20260510%WP4534%HOMO SAPIENS Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms YAP1 PAK4 MAPK10 ITGB1 LIMD1 PS1TP5BP1 MAPK9 MAPK8 TEAD2 TEAD3 MAP4K1 MAP4K2 MAP4K3 ACTG2 ITGB7 WWTR1 CTNNA1 SGMS1 ACTG1 CTNNB1 PAK1 ITGB6 YWHAQ TEAD4 NF2 ITGB4 SRC HEL-S-31 LATS1 ITGB3 ACTA1 ITGB5 ACTA2 ITGB8 PAK6 NUCLEOTIDE METABOLISM%WIKIPATHWAYS_20260510%WP404%HOMO SAPIENS Nucleotide metabolism OAZ1 NME2 RRM2B ADSL MTHFD2 RRM1 IMPDH1 RRM2 HPRT1 ADSS SRM DHFR POLA1 POLG EV RELEASE FROM CARDIAC CELLS AND THEIR FUNCTIONAL EFFECTS%WIKIPATHWAYS_20260510%WP3297%HOMO SAPIENS EV release from cardiac cells and their functional effects PRL ERBB4 CXCL12 KLF2 RGS16 MYB NEOVASCULARIZATION PROCESSES%WIKIPATHWAYS_20260510%WP4331%HOMO SAPIENS Neovascularization processes EPHB2 EPHB4 RELA REL NOTCH3 MAPK9 MAPK8 MAPK3 FLT4 DLL4 TGFB1 ACVRL1 MAPK1 CXCR4 SMAD2 KDR NFKB1 MMP9 TGFBR1 KITLG RELB ANGPT1 HIF1A CXCL12 SMAD1 SMAD9 KIT NOTCH1 DKFZp781O1323 NFKB2 DYRK1A INVOLVEMENT REGARDING CELL PROLIFERATION IN BRAIN DEVELOPMENT%WIKIPATHWAYS_20260510%WP5180%HOMO SAPIENS DYRK1A involvement regarding cell proliferation in brain development CREB1 REST HES5 HES1 RPTOR DEPTOR CCND1 MLST8 FGF2 TSC2 TSC1 EIF2B5 RBL2 AKT1S1 RBL1 NEUROG2 TFDP1 NFATC1 TFDP2 PSEN1 FOXO1 E2F4 E2F5 DNER CRY2 RBBP4 DYRK1A CSNK1A1 MTOR H3F3B CDK6 LIN54 GMNN CDK4 LIN52 PSENEN TFDP3 DCAF7 AMPH LIN37 SPRY2 LIN9 TFAP4 SIRT1 NOTCH1 APP GSK3B CASP9 CDKN1B CASP3 LATS2 BACE1 APOPTOSIS%WIKIPATHWAYS_20260510%WP254%HOMO SAPIENS Apoptosis DIABLO MCL1 APAF1 LTA BBC3 TNFSF10 CASP8 RELA BCL2L11 TNFSF6 FADD BCL2L1 BOK IRF1 IGF1R MYC FAS IGF2 CYCS BCL2 IRF4 TNFRSF10B MAP2K4 TNFRSF1B JUN IGF1 IRF3 MAPK10 NFKBIB IRF7 CDKN2A MDM2 TP63 NFKBIE BIRC5 TP73 TRAF1 IKBKB BIRC3 NFKBIA MAP3K1 CHUK TRADD HRK PRF1 IKBKG CASP4 HELLS SCAF11 NFKB1 IRF2 TNFRSF25 TNFRSF21 CASP10 CRADD BCL2L2 TNF TRAF2 PIK3R1 TRAF3 IRF6 CASP6 BIRC2 CASP2 BAK1 DFFB RIPK1 BAD DFFA PMAIP1 BNIP3L BAX CASP9 CASP3 TNFRSF1A MIRNA REGULATION OF PROSTATE CANCER SIGNALING%WIKIPATHWAYS_20260510%WP3981%HOMO SAPIENS miRNA regulation of prostate cancer signaling MTOR PDGFA MDM2 KRAS KLK3 GRB2 CDKN1A CREBBP NFKBIA CCND1 MAPK1 IKBKG RAF1 AKT3 NFKB1 MAP2K2 BCL2 CTNNB1 BAD SOS1 GSK3B PIK3CA CASP9 CDKN1B FOXO1 MAP2K1 NOVEL INTRACELLULAR COMPONENTS OF RIG I LIKE RECEPTOR PATHWAY%WIKIPATHWAYS_20260510%WP3865%HOMO SAPIENS Novel intracellular components of RIG I like receptor pathway MAPK12 MAPK11 CASP8 RELA FADD MAPK9 MAPK8 MAPK14 ATG5 IFNG ATG12 CXCL12 IFNA1 IFIH1 TBK1 IKBKE IRF3 MAPK10 NFKBIB IRF7 RIGI IKBKB NFKBIA MAP3K1 CHUK TRADD TRAF6 IKBKG NLRX1 NFKB1 MAPK13 DHX58 TRIM25 CASP10 MITA DDX3Y TNF OTUD5 TRAF2 DDX3X MAVS AZI2 SIKE1 TRAF3 RNF125 IFNE TANK IFNK CYLD RIPK1 SNW1 PIN1 IFNB1 TBKBP1 CXCL8 MAP3K7 ISG15 TYPE II INTERFERON SIGNALING%WIKIPATHWAYS_20260510%WP619%HOMO SAPIENS Type II interferon signaling IRF9 HLA-B NOS2 JAK1 SPI1 IL1B CXCL9 STAT1 IRF1 CYBB H4C9 IFIT2 SOCS1 IFNGR1 IRF2 IFNA2 IFNG IRF4 SOCS3 IFNB1 PTPN11 IFI6 GBP1 STAT2 TAP1 MHC2TA IFNGR2 EIF2AK2 OAS1 ISG15 IRF8 BIOSYNTHESIS AND REGENERATION OF TETRAHYDROBIOPTERIN AND CATABOLISM OF PHENYLALANINE%WIKIPATHWAYS_20260510%WP4156%HOMO SAPIENS Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine ASMT PNMT SPR TH JDP1 MAOA PTS DBH AANAT PAH DHFR GLIOBLASTOMA SIGNALING%WIKIPATHWAYS_20260510%WP2261%HOMO SAPIENS Glioblastoma signaling EP300 MAP2K3 BRCA2 MAP2K5 PRKCZ CDKN1A PLCG2 FOXO3A PLCG1 MAPK3 PTEN PIK3CD IGF1R BRAF CCND1 AKT3 HRAS PDGFRA MAP2K2 CDK2 TSC2 TSC1 MAP2K4 MET PDPK1 PIK3CA SRC RB1 EGFR FOXO1 CBL CDKN2B ERBB3 CDKN2C BRCA1 CDKN2A MDM2 KRAS GRB2 MSH6 CDK6 CDK4 FGFR2 FOXO4 FGFR1 ARAF SPRY2 MAPK1 RAF1 MAP2K6 PIK3R2 PIK3R1 NRAS NF1 MDM4 PRKCH PRKCB CDKN1B PRKCA ERRFI1 CCNE1 ATM IRS1 PIK3C2G PRKCI PIK3C2A MAP2K1 CCND2 PIK3C2B PRKCQ ERBB2 SOMATROPH AXIS GH AND ITS RELATIONSHIP TO DIETARY RESTRICTION AND AGING%WIKIPATHWAYS_20260510%WP4186%HOMO SAPIENS Somatroph axis GH and its relationship to dietary restriction and aging PTEN MTOR IGF1R SIRT1 FOXO1 INHIBITION OF GNAQ REGULATED SIGNALING IN UVEAL MELANOMA%WIKIPATHWAYS_20260510%WP5490%HOMO SAPIENS Inhibition of GNAQ regulated signaling in uveal melanoma YAP1 TRIO MTOR PKN3 PKN2 PKN1 TEAD2 TEAD3 PLCB1 PIK3CD MAPK1 ROCK1 AKT3 PLCB2 ARHA PIK3R3 PIK3R2 PIK3R1 TSC2 TSC1 PLCB4 MOB1A TEAD4 PLCB3 PIK3CA LATS1 LATS2 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260510%WP47%HOMO SAPIENS Hedgehog signaling ADRBK1 SUFU KIF7 IHH PTCH2 SAP18 SIN3A SHH PTCH1 DHH GLI3 SMO OSTEOPONTIN SIGNALING%WIKIPATHWAYS_20260510%WP1434%HOMO SAPIENS Osteopontin signaling MAPK3 IKBKB CHUK RELA ITGB3 SPP1 MAPK1 MAP2K1 MAP3K14 ITGAV NFKB1 MMP9 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES AUTOPHAGY%WIKIPATHWAYS_20260510%WP4863%HOMO SAPIENS Host pathogen interaction of human coronaviruses autophagy ATG10 WIPI1 MTOR ATG12 ATG16L1 ULK2 RB1CC1 ULK1 ZFYVE1 ATG16L2 PIK3R4 MAP1LC3A ATG5 ATG3 CYTOSOLIC DNA SENSING PATHWAY%WIKIPATHWAYS_20260510%WP4655%HOMO SAPIENS Cytosolic DNA sensing pathway CASP8 RELA FADD POLR3GL POLR3A POLR1C POLR3B POLR1D POLR3C POLR3D POLR3E POLR3F POLR3G POLR3K CCL5 POLR2F ATG5 CCL4 POLR2H POLR2K POLR2L ATG12 RIPK3 IFNA1 IF1AA9 CGAS TBK1 IKBKE IFNA13 IFNA14 IRF3 NFKBIB IFNA16 IRF7 CCL4L2 IFNA17 RIGI IFNA10 IFNA21 IKBKB IL1B NFKBIA CHUK TRADD IKBKG IL33 NLRX1 IFNA4 NFKB1 IFNA7 IL18 IFNA6 IFNA2 TRIM25 IFNA8 CASP10 MITA POLR3H PYCARD MAVS IL6 RNF125 CYLD RIPK1 IFNB1 ADAR ZBP1 AIM2 TREX1 ISG15 6Q16 COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5400%HOMO SAPIENS 6q16 copy number variation INSR BDNF MC4R NPY AgRP GHRL POMC GHSR INS LEPR NTRK2 LEP SIM1 CHOLESTEROL SYNTHESIS DISORDERS%WIKIPATHWAYS_20260510%WP5193%HOMO SAPIENS Cholesterol synthesis disorders DHCR7 HMGCS1 EBP HMGCR IDI1 SC5D FDPS HSD3B2 MVK DHCR24 MSMO1 SQLE PMVK MVD FDFT1 CYP51A1 LBR CELL INTERACTIONS IN PANCREATIC CANCER MICROENVIRONMENT%WIKIPATHWAYS_20260510%WP5284%HOMO SAPIENS Cell interactions in pancreatic cancer microenvironment BAG3 CSF2 CTLA4 NRP1 CSF1 TNFSF6 CCR2 CCR5 TGFB1 HLA-DRA CXCR4 FAS KDR CCL5 CXCR3 CCL2 LAG3 CXCL12 ITGB6 CSF2RA CSF1R VEGFA CD80 HLA-DRB1 IFITM2 CHOLESTEROL BIOSYNTHESIS PATHWAY IN HEPATOCYTES%WIKIPATHWAYS_20260510%WP5329%HOMO SAPIENS Cholesterol biosynthesis pathway in hepatocytes PLPP6 ELOVL4 CYP46A1 MSMO1 TM7SF2 ABCG1 NR1H3 LBR CYP7A1 ABCA1 MYLIP HMGCS1 ELOVL5 ACSL1 ELOVL2 HSD17B7 CH25H EBP ELOVL3 HMGCR IDI1 SC5D ACSL3 FADS2 FDPS CYP27A1 MVK SCD GGPS1 IDI2 ACAT2 DHCR24 PMVK NR1H2 MVD FDFT1 CYP51A1 TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20260510%WP465%HOMO SAPIENS Tryptophan metabolism TPH2 AADAT HAAO IL4I1 IDO1 TDO2 AFMID AOC1 KYAT3 KYNU KYAT1 KMO IDO2 ALDH8A1 ECHS1 ASMT STAT1 AHR DLD AANAT ALDH2 CYP1A1 DDC MAOA GOT2 AOX1 INMT ACAT1 TPH1 GCDH T CELL MODULATION AND DESMOPLASIA IN PANCREATIC CANCER%WIKIPATHWAYS_20260510%WP5078%HOMO SAPIENS T cell modulation and desmoplasia in pancreatic cancer LGALS9 CTLA4 IDO1 PDGFD PDGFC PDCD1 PDGFA SHH TNFSF6 VTCN1 VSIR IL13 TIGIT IL10 B2M TNFRSF9 FAP TGFB1 CD226 CCL17 ICOS CD40LG CCL22 CXCR4 TNFRSF4 FAS TNLG5A ARG1 VEGFB NT5E NR1i1 HAVCR2 IL6 VEGFD CXCL12 TNLG2B CD40 ENTPD1 IL4 VEGFA PDCD1LG2 VEGFC HLA-A CD80 FLUOROACETIC ACID TOXICITY%WIKIPATHWAYS_20260510%WP4966%HOMO SAPIENS Fluoroacetic acid toxicity ACSS2 ACO2 ALDH2 ALDH3A2 CS ALDH9A1 COPPER METABOLISM%WIKIPATHWAYS_20260510%WP5189%HOMO SAPIENS Copper metabolism ATP7B ATP7A SLC31A1 SLC11A2 GLUCURONIDATION%WIKIPATHWAYS_20260510%WP698%HOMO SAPIENS Glucuronidation UGT2B11 UGT2B7 UGT2B15 UGT2B17 UGT1A10 UGT2B28 UGT1A8 UGT1A5 UGT1A9 UGT2A2 UGT2A1 UGT1A4 UGT1A3 UGT1A7 UGT2B10 UGDH PGM3 PGM2 PGM5 UGT1A1 UGT2B4 FLAVAN 3 OL METABOLIC PATHWAY%WIKIPATHWAYS_20260510%WP4238%HOMO SAPIENS Flavan 3 ol metabolic pathway MIR 222 IN EXERCISE INDUCED CARDIAC GROWTH%WIKIPATHWAYS_20260510%WP3938%HOMO SAPIENS miR 222 in exercise induced cardiac growth CDKN1B HMBOX1 HIPK1 HIPK2 DISORDERS OF FRUCTOSE METABOLISM%WIKIPATHWAYS_20260510%WP5178%HOMO SAPIENS Disorders of fructose metabolism GLYCTK SLC2A2 HEL-S-49 PFKL SLC5A1 ALDOB G6PC1 HEL-S-53e KHK SORD FBP1 INTERACTIONS OF NATURAL KILLER CELLS IN PANCREATIC CANCER%WIKIPATHWAYS_20260510%WP5092%HOMO SAPIENS Interactions of natural killer cells in pancreatic cancer CSF2 BMI1 TIGIT CCL1 CD226 NCR1 NCR3 PRF1 MYC FCGR3A KLRK1 CCL5 NCR3LG1 CCL4 MICB CCL3 CD96 CCL2 IFNG TNF MICA FOXO1 ADAM10 GATA2 ADAM17 13Q12 OR CRYL1 COPY NUMBER VARIATION %WIKIPATHWAYS_20260510%WP5405%HOMO SAPIENS 13q12 or CRYL1 copy number variation HEL30 COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260510%WP558%HOMO SAPIENS Complement and coagulation cascades C1R CFI C5AR1 C4B_2 C2 C6 PLAT C7 C9 CD55 HEL-S-62p C1QC THBD VWF SERPINF2 F5 F8 CPB2 SERPINC1 TFPI LMAN1 CLTC F2R SERPIND1 PLAUR KLKB1 F7 PLG F3 HEL-S-78p KNG1 BDKRB1 F13B F2 PROS1 CLU C8G SERPINA1 C3AR1 F9 PROC CR2 F10 CR1 SERPING1 MASP2 C1QA MASP1 CD46 CFD C1QB C1S CFH HORMONAL CONTROL OF PUBERTAL GROWTH SPURT%WIKIPATHWAYS_20260510%WP4194%HOMO SAPIENS Hormonal control of pubertal growth spurt GH1 GHRH GNRH1 IGF1 SST RESISTIN AS A REGULATOR OF INFLAMMATION%WIKIPATHWAYS_20260510%WP4481%HOMO SAPIENS Resistin as a regulator of inflammation RELA PLCD4 PLCG2 IL12B PLCG1 PLCB1 MAPK3 IL12A IKBKB PIK3CD NFKBIA CHUK MAPK1 MAPK14 IKBKG AKT3 PLCB2 NFKB1 PLCE1 TNF IL6 PLCB4 PLCD3 CXCL8 PLCB3 PIK3CA RETN MAPK SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260510%WP5530%HOMO SAPIENS MAPK signaling and ARTD family members MAP2K3 MAPK12 MAPK10 MAPK11 MAP3K11 MAPK9 MAPK8 MAP3K8 MAPK3 PARP14 ARAF MAP3K1 BRAF MAPK1 MAPK14 RAF1 MAP2K6 MAPK13 ATF4 MAP2K2 MAP3K10 MAP3K21 MAP2K4 TNKS MAP3K7 MAP3K5 MAP2K1 PARP1 MAP3K12 ENDOTHELIN PATHWAYS%WIKIPATHWAYS_20260510%WP2197%HOMO SAPIENS Endothelin pathways GNAI1 EDNRA EDNRB ADRB1 CAD PLCB1 GNG13 MAPK1 RAF1 GNAS GNB5 MYLK CALM1 ATP2A2 GNA15 ADRA1A COX2 MYL1 HEL-S-14 PTGIR NPY1R EDN1 RIIAD1 RAMP1 CALCA ECE1 HEL-S-7a NPY CALCRL PRKCA MAP2K1 TYPE II DIABETES MELLITUS%WIKIPATHWAYS_20260510%WP1584%HOMO SAPIENS Type II diabetes mellitus SLC2A2 INSR SLC2A4 PHKA2 TNF CACNA1A MTOR PRKCZ PDX1 MAPK8 MAFA INS-IGF2 SURF1 IKBKB SOCS4 IRS1 MAPK1 PIK3R5 NICOTINE EFFECT ON CHROMAFFIN CELLS%WIKIPATHWAYS_20260510%WP1603%HOMO SAPIENS Nicotine effect on chromaffin cells CHRNB4 CACNA1G CACNA1C CHRNA3 GLYOXYLATE METABOLISM%WIKIPATHWAYS_20260510%WP5166%HOMO SAPIENS Glyoxylate metabolism GOT2 SLC26A1 PXMP2 HAO1 AGXT HOGA1 PRODH2 HEL-S-133P DAO NUCLEOTIDE GPCRS%WIKIPATHWAYS_20260510%WP80%HOMO SAPIENS Nucleotide GPCRs ADORA2A LTB4R P2RY6 LPAR4 P2RY4 ADORA2B P2RY2 P2RY1 PHOTODYNAMIC THERAPY INDUCED NFE2L2 NRF2 SURVIVAL SIGNALING%WIKIPATHWAYS_20260510%WP3612%HOMO SAPIENS Photodynamic therapy induced NFE2L2 NRF2 survival signaling SRXN1 MAPK12 CES1 MAPK11 ABCC3 ABCC2 HMOX1 MAPK8 JUN NFE2L2 NQO1 EPHX1 ABCG2 MAPK14 GCLC GCLM HEL-S-22 MAPK13 NQO2 FOS ABCC6 KEAP1 T CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP69%HOMO SAPIENS T cell receptor signaling ZAP70 CREB1 GAB2 RELA MAPK9 GRAP2 MAPK8 MAP3K8 PLCG1 MAPK3 LCP2 CARD11 CD3G VAV3 BCL10 ICOS CD3E CD3D MAPK14 HRAS MAP2K2 LCK CRKL SOS1 NFATC1 NCK1 PDPK1 JUN SHC1 LAT CRK ATF2 CBL ITK HEL-S-81p PSTPIP1 NFATC2 RIPK2 CD8A SH2B3 FYN FYB1 REL GRB2 MAP4K1 IKBKB NFKBIA VAV1 PTK2B CHUK TRAF6 MAPK1 IKBKG RAF1 MAP3K14 WAS NFKB1 CDC42 PIK3R2 PIK3R1 PAK1 PTPN11 MAP3K7 MAP2K1 FOS PRKCQ RALA DOWNSTREAM REGULATED GENES%WIKIPATHWAYS_20260510%WP2290%HOMO SAPIENS RalA downstream regulated genes CDC42 NRAS YBX3 EXOC2 RALBP1 EXOC8 KRAS RAC1 RALA RAC3 HRAS CANONICAL NF KB PATHWAY%WIKIPATHWAYS_20260510%WP4562%HOMO SAPIENS Canonical NF kB pathway IKBKB NFKBIA CHUK RELA REL IKBKG NFKB1 NFKBIE ATM SIGNALING IN DEVELOPMENT AND DISEASE %WIKIPATHWAYS_20260510%WP3878%HOMO SAPIENS ATM signaling in development and disease CHEK1 MRE11A NBN MAPK12 MTOR MAPK11 RIF1 NHEJ1 ATMIN PPP5C CEP63 CDK5 PRKDC MAPK14 RNF168 MDC1 IKBKG RNF8 NFKB1 MAPK13 STK11 PPP2CA CDK2 ATR HMGN1 TSC2 SMC1A PPM1D RBBP8 TP53BP1 TRIM28 AURKB ATM LMNB2 HEL-S-102 ATF2 KAT5 RAD50 CHEK2 FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260510%WP143%HOMO SAPIENS Fatty acid beta oxidation GPD2 LIPF DECR1 CHKB CRAT ECHS1 ACSS2 DLD CPT1A ACSL6 ACSL5 HEL-S-49 LIPE CPT2 LIPC LPL ACADM ACSL1 FACL4 ACSL3 ACADVL PNPLA2 ACADL HADHB SLC25A20 ACADS ACAT1 GCDH HIPPO SIGNALING REGULATION%WIKIPATHWAYS_20260510%WP4540%HOMO SAPIENS Hippo signaling regulation YAP1 PRKAA2 CDH11 PRKCZ FLT1 PLCB1 FLT3 FLT4 IGF1R SMAD2 KDR GNAS ARHA PDGFRA WWTR1 CTNNB1 PRKACG PLCB4 KIT TEAD4 MET EPHA2 PLCB3 CSF1R TCF7L2 LEF1 EGFR GNAI3 NTRK1 NGFR NTRK2 INSR CDH2 TCF7L1 MTOR GNA11 TEAD2 FGFR4 TEAD3 FGFR3 FGFR2 FGFR1 PRKAB2 PRKAB1 RAC1 CDH17 PRKD3 PLCB2 CDH9 CDH8 CDH6 CDC42 CDH4 PRKAG1 GNAL PRKAG2 CDH24 PRKAG3 PRKAA1 NF2 PRKCH PRKCB PRKCE PRKCA LATS1 LATS2 CDH10 PRKCI CDH12 PRKAR1B CDH15 CDH16 PRKAR1A CDH18 CDH19 PRKCQ TYROSINE KINASE INHIBITORS IN GLIOBLASTOMA%WIKIPATHWAYS_20260510%WP5494%HOMO SAPIENS Tyrosine kinase inhibitors in glioblastoma EGF STAT3 TSC2 TSC1 MTOR NRAS RHEB JAK3 KRAS GRB2 SOS1 SOS2 JAK1 PTEN EREG BTC RPTOR RAF1 TGFA AKT3 TYK2 HRAS CANONICAL AND NON CANONICAL TGF B SIGNALING%WIKIPATHWAYS_20260510%WP3874%HOMO SAPIENS Canonical and non canonical TGF B signaling TGFBR2 MAPK9 MAPK8 BMP1 LOXL4 LOX LOXL1 LOXL2 TGFB1 BMPR1A BMPR2 MAPK14 SMAD2 SMAD4 GREM1 TGFBR1 AMINO ACID TRANSPORT DEFECTS IEMS %WIKIPATHWAYS_20260510%WP5029%HOMO SAPIENS Amino acid transport defects IEMs SLC3A2 SLC7A7 SLC36A2 CLTRN SLC7A9 SLC3A1 SLC6A20 SLC1A1 SLC6A19 KCNQ2 AND KCNQ3 RELATED EPILEPSY%WIKIPATHWAYS_20260510%WP5599%HOMO SAPIENS KCNQ2 and KCNQ3 related epilepsy FGF13 FGF12 DAG1 RAB11A RAB1A ZNF547 TRAPPC3 SNAP25 PRRT2 GIGYF1 TRAPPC6B SCN8A KCNQ5 STX1A SCN2A SCN4B CALM1 AKAP5 VAMP2 NEDD4 KCNQ2 KCNQ3 PRKCE CAMK2A BACE1 IRON METABOLISM DISORDERS%WIKIPATHWAYS_20260510%WP5172%HOMO SAPIENS Iron metabolism disorders CYBRD1 HEPH TF CP FTH1 HFE HFE2 FTL STEAP3 UQCRFS1 TFR2 SLC40A1 SLC11A2 PANK2 HAMP TFRC OXYTOCIN SIGNALING%WIKIPATHWAYS_20260510%WP2889%HOMO SAPIENS Oxytocin signaling OXTR H19 RB E2F1 AND CDK BETA CATENIN IN COLORECTAL CANCER%WIKIPATHWAYS_20260510%WP3969%HOMO SAPIENS H19 Rb E2F1 and CDK beta catenin in colorectal cancer CDK4 CDK8 CSRP2 CTNNB1 MACROH2A1 SOX4 MED1 RB1 CCND1 PMAIP1 NAD BIOSYNTHESIS II FROM TRYPTOPHAN%WIKIPATHWAYS_20260510%WP2485%HOMO SAPIENS NAD biosynthesis II from tryptophan HAAO NMNAT1 TDO2 HEL-S-90n AFMID KYNU KMO NADSYN1 OSTEOBLAST SIGNALING%WIKIPATHWAYS_20260510%WP322%HOMO SAPIENS Osteoblast signaling COL1A1 PDGFRA TNFSF11 PTH1R BGLAP IBSP ITGB3 FGF23 SLC17A2 PTH ITGAV TNFRSF11B IMMUNE INFILTRATION IN PANCREATIC CANCER%WIKIPATHWAYS_20260510%WP5285%HOMO SAPIENS Immune infiltration in pancreatic cancer LGALS9 CSF2 REG4 IL13 IL12B IL10 IL12A TGFB1 IL1B CXCL1 CCL20 IL2 CXCL5 CCL28 CCL5 VEGFB MMP9 IL17B CCL2 IFNG TNF IL23A IL25 IL6 VEGFD CXCL12 IL4 CXCL8 VEGFA IL17F IL17D IL17C IL17A VEGFC IL5 16P13 11 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260510%WP5502%HOMO SAPIENS 16p13 11 copy number variation syndrome DCTN6 DCTN1 DCTN4 PAFAH1B1 OFD1 ABCC1 PLK1 CEP20 DISC1 GATA3 PLAG1 PCM1 ACTR1B BMERB1 NDE1 MARF1 DCP1A CEP170 ACTR10 RAP1A PLAGL1 DCP2 RAPGEF4 KIAA0753 ABCC6 BREAST CANCER PATHWAY%WIKIPATHWAYS_20260510%WP4262%HOMO SAPIENS Breast cancer pathway MRE11A NBN BRCA2 SKP1 CSNK1A1L JAG2 DLL3 HES1 MAPK3 DLL4 NCOA1 BRAF FGF2 SP1 ATR CTNNB1 FGF7 FGF8 FGF9 JUN WNT4 PIK3CA FGF20 RB1 FGF23 FGF22 FGF21 IGF1 HEY2 FGF16 FGF18 FGF10 WNT2B FZD10 WNT5B FGF8A NOTCH3 WNT16 SFRP4 CDK6 APC2 CDK4 WNT3 FGF7B WNT10B WNT10A FRAT2 FZD3 FGF7A FZD2 FZD5 MAPK1 WNT3A RAF1 WNT7B FZD7 FZD9 FGF6B WNT7A FZD8 FGF5C CETN3 ERBB2 HES5 CSNK2A3 CSNK2A2 CDKN1A CSNK2B FLT4 PTEN PIK3CD IGF1R NR3A2 RPS6KB1 RPS6KB2 CCND1 PGR MYC AKT3 HRAS MAP2K2 TNFSF11 AXIN2 KIT FRAT1 SOS1 SOS2 DVL1 DVL2 DVL3 SHC1 TCF7L2 LEF1 AXIN1 LRP5 EGFR SHC4 LRP6 SHC3 WNT1 CSNK1A1 EGF TCF7L1 MTOR CSNK2A1 APC BRCA1 KRAS FZD1 GRB2 FGFR1 ARAF POLK DDB2 SHC2 PIK3R3 PIK3R2 PIK3R1 NRAS E2F2 E2F3 NOTCH2 BAK1 GADD45B NOTCH1 GADD45A GADD45G GSK3B BAX NFKB2 ATM MAP2K1 PARP1 FOS RAD50 RAD51 RELATIONSHIP BETWEEN INFLAMMATION COX 2 AND EGFR%WIKIPATHWAYS_20260510%WP4483%HOMO SAPIENS Relationship between inflammation COX 2 and EGFR NRAS KRAS PTGER4 PTGS2 PTGER1 PTGER2 PTGER3 MAPK3 PIK3CA SRC PIK3CD BRAF EGFR MAPK1 PLA1A AKT3 HRAS EXTRAFOLLICULAR AND FOLLICULAR B CELL ACTIVATION BY SARS COV 2%WIKIPATHWAYS_20260510%WP5218%HOMO SAPIENS Extrafollicular and follicular B cell activation by SARS CoV 2 TLR4 CXCL13 BCL6 PRDM1 IL10 CRP IL12A SYK ICOS CD40LG HEL-S-62p IL-21 CXCR4 IL2 CD82 IFNG CD79A TNFSF13 IRF4 PTPRC CD19 CXCL12 SELL CD69 TBX21 IL4 GPR183 BCR FOXO1 IRF8 TNLG7A TLR7 CCR7 PDCD1 CXCR5 CCL19 IFITM1 PAX5 CCL21 IFIT2 HEL-S-72p C4A ITGAX IFNAR2 TNF MS4A1 IL6 CR2 CR1 CD40 BACH2 BLNK MFGE8 BTLA AID CD80 TMSB10 ICOSLG FCRL5 EBI3 ZEB2 CD1D SLAMF7 XBP1 MAF SH2D1A ISG15 CD22 CAFFEINE IN MYOCYTES%WIKIPATHWAYS_20260510%WP5603%HOMO SAPIENS Caffeine in myocytes TNNI1 TNNI2 TNNI3 MYL11 TNNC2 TPM3 MYH1 HEL-S-108 TNNT3 MYH8 MYH4 PS1TP5BP1 MYH7 MYL6 TNNT1 TNNC1 ACTG2 RYR1 ACTG1 RYR2 RYR3 MYL1 MYL3 MYH6 TPM1 ACTA1 MYH2 MYL2 ACTA2 HEL-S-273 MYH13 TCA CYCLE NUTRIENT USE AND INVASIVENESS OF OVARIAN CANCER%WIKIPATHWAYS_20260510%WP2868%HOMO SAPIENS TCA cycle nutrient use and invasiveness of ovarian cancer MAPK3 JAK1 STAT3 EGFR MAPK1 HIPPO YAP SIGNALING%WIKIPATHWAYS_20260510%WP4537%HOMO SAPIENS Hippo YAP signaling WWTR1 YAP1 TNIK STK38L TEAD2 MAP4K1 TEAD3 TEAD4 MAP4K2 MINK1 NF2 HEL-S-31 LATS1 LATS2 MAP4K3 RASSF1 MALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260510%WP5320%HOMO SAPIENS Male steroid hormones in cardiomyocyte energy metabolism HSD17B3 SRD5A2 HSD17B2 HSD3B2 HSD3B1 SULT1A1 UGT1A1 CYP11A1 CYP17A1 IL10 ANTI INFLAMMATORY SIGNALING%WIKIPATHWAYS_20260510%WP4495%HOMO SAPIENS IL10 anti inflammatory signaling JAK1 STAT3 STAT1 IL6 HEL-S-10 HMOX1 IL10RB IL10 IL1A IL10RA STAT2 COLCHICINE METABOLIC PATHWAY%WIKIPATHWAYS_20260510%WP2536%HOMO SAPIENS Colchicine metabolic pathway CYP3A4 ESTROGEN SYNTHESIS AND METABOLISM%WIKIPATHWAYS_20260510%WP5276%HOMO SAPIENS Estrogen synthesis and metabolism UGT2B7 UGT1A10 SULT1E1 UGT1A8 CYP3A4 HSD17B10 CYP2C19 CYP1B1 UGT2A2 CYP2C9 CYP2C8 HSD17B7 CYP1A2 HSD17B3 HSD17B2 HSD17B1 HSD17B4 CYP3A7 SILDENAFIL TREATMENT%WIKIPATHWAYS_20260510%WP5294%HOMO SAPIENS Sildenafil treatment PARK2 PRKG1 NRF1 NOS2 GUCY1A2 ZNF746 TFAM GSK3B PDE4B PDE4A PDE4D AKT3 GUCY1B1 PPARGC1A PDE5A HEL-S-162eP JOUBERT SYNDROME%WIKIPATHWAYS_20260510%WP4656%HOMO SAPIENS Joubert syndrome TMEM231 MRE11A TTC8 TMEM17 MKS1 CETN2 B9D1 CCP110 ARR3 TMEM138 ARL2 NPHP1 INVS MYO6 PDE6A PCNT PDE6G RAB3IP TMEM237 UNC119 B9D2 CEP164 ARHA DVL1 DVL3 RAB8A KAT5 TCTN3 FLNA TCTN2 TCTN1 BBS9 BBS7 MTOR CEP97 RP2 RHEB SHH CC2D2A BBS5 BBS4 OFD1 PDE6D NPHP3 ARMC9 RPGRIP1L CEP41 NEK8 TMEM216 ATF4 SUFU CEP104 ZNF423 ARL3 PCM1 AHI-1 ARL13B TMEM67 INPP5E CEP290 PIBF1 ATM BBS2 BBS1 CPLANE1 PARP1 RAD50 UREA CYCLE AND RELATED DISEASES%WIKIPATHWAYS_20260510%WP4571%HOMO SAPIENS Urea cycle and related diseases ASL SLC25A15 NAGS SLC25A13 OTC GLS2 ARG1 ASS1 FEMALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260510%WP5318%HOMO SAPIENS Female steroid hormones in cardiomyocyte energy metabolism STK11 ESRRA SLC2A4 PPARGC1B APOB HADHB ACADM NR1C1 ACLY MTTP ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY%WIKIPATHWAYS_20260510%WP2118%HOMO SAPIENS Arrhythmogenic right ventricular cardiomyopathy CACNA1C DSG2 DAG1 CACNA1S CACNG2 ITGA4 JUP ACTN2 CACNA2D3 CACNA2D2 CACNA2D4 CACNB4 PKP2 DSC2 ACTG1 CACNA1F CTNNB1 RYR2 CACNG6 ATP2A2 CACNG7 CACNG8 CACNG1 CACNG3 ITGB6 CACNG4 CACNG5 ACTN1 ACTN4 TCF7L2 LEF1 ITGB3 ITGA6 ITGB5 CACNA2D1 ITGAV ITGB8 ITGA7 ITGA2B CDH2 ITGB1 TCF7L1 PS1TP5BP1 ITGA1 LMNA ITGA2 ITGB7 CTNNA1 CTNNA3 SLC8A1 CTNNA2 SGCD SGCA GJA1 SGCB SGCG tmp_locus_29 DMD ITGB4 EMD CACNB1 CACNB3 GLYCOSPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260510%WP5292%HOMO SAPIENS Glycosphingolipid metabolism NEU4 UGT8 UGCG ST3GAL5 GLA B3GNT5 B4GALNT1 A4GALT GBA2 A3GALT2 B3GALT2 B4GALT5 B3GALT1 B4GALT4 NEU3 INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260510%WP5120%HOMO SAPIENS Inclusion body myositis PSENEN NFKB2 PSEN2 SIRT1 PSEN1 GDF8 APP NFKB1 BACE1 CELLS AND MOLECULES INVOLVED IN LOCAL ACUTE INFLAMMATORY RESPONSE %WIKIPATHWAYS_20260510%WP4493%HOMO SAPIENS Cells and molecules involved in local acute inflammatory response TNF VCAM1 ITGB1 IL6 KNG1 IL1A C6 C7 CXCL8 ITGA4 SELP HEL-S-62p SELPLG TGIF DISRUPTION OF SHH SIGNALING%WIKIPATHWAYS_20260510%WP3674%HOMO SAPIENS Tgif disruption of Shh signaling NKX2-1 FGF8 NODAL SHH SMAD2 TGIF1 GLI3 TGIF2 FOXG1 LDLRAD4 INTRONIC SNP EFFECT ON COVID PATIENTS%WIKIPATHWAYS_20260510%WP4904%HOMO SAPIENS LDLRAD4 intronic SNP effect on COVID patients TGFBR2 NEDD4 SMAD2 ATG16L1 TMEPAI TGFBR1 NOTCH SIGNALING%WIKIPATHWAYS_20260510%WP61%HOMO SAPIENS Notch signaling NCOR1 EP300 HES5 STAT3 SKP1 MTOR NOTCH3 SAP30 HES6 JAG2 DLL3 HES1 DLL4 PSENEN PSEN2 NFKB1 FHL1 MAML1 PIK3R2 PIK3R1 LCK NUMB FBXW7 NOTCH2 NOTCH1 SNW1 GSK3B DTX1 APH1B NCOR2 MAGEA1 HDAC2 SRC CIRSR SPEN HDAC1 ITCH MAML2 PSEN1 RBPJ HEY2 ADAM17 MAML3 SULINDAC METABOLIC PATHWAY%WIKIPATHWAYS_20260510%WP2542%HOMO SAPIENS Sulindac metabolic pathway CYP1A2 MSRA MSRB2 MSRB3 CYP1B1 METABOLISM OF SPHINGOLIPIDS IN ER AND GOLGI APPARATUS%WIKIPATHWAYS_20260510%WP4142%HOMO SAPIENS Metabolism of sphingolipids in ER and Golgi apparatus B4GALT1 CERK SGMS1 SPHK1 SGMS2 UGT8 UGCG B4GALNT1 KDSR B3GALT2 SPHK2 GALNT1 SGPP2 B4GALT2 SGPP1 B3GALT1 GALNT16 SGPL1 CERS3 MEASLES VIRUS INFECTION%WIKIPATHWAYS_20260510%WP4630%HOMO SAPIENS Measles virus infection TLR4 IL2RG RELA CCNE2 JAK3 MAPK9 MAPK8 IL12B IL1A IL12A IL2 CDK2 BCL2 HEL70 TNFAIP3 JUN PIK3CA IFNA1 IF1AA9 IRAK1 IFNA13 IFNA14 NFKBIB IFNA16 IFNA17 IFNA10 IFNA21 CDK6 CDK4 IKBKB NFKBIA CHUK TRADD TRAF6 IKBKG NFKB1 IFNA4 IFNA7 IFNA6 IFNA2 IFNA8 IFNAR2 IFNAR1 IFNB1 STAT2 MX1 MAP3K7 CD46 APAF1 BBC3 CASP8 TNFSF6 CSNK2A3 FADD CSNK2A2 BCL2L1 CSNK2B JAK1 STAT5B PIK3CD CD3G STAT1 CD3E CCND1 CD3D IRAK4 FAS CYCS TYK2 CLEC4M IL2RB MYD88 IL2RA CD209 LNIR EIF2AK2 EIF2AK1 OAS1 EIF2AK4 OAS2 IFIH1 HEL-S-103 TBK1 EIF3S3 TLR9 IRF9 RCHY1 IKBKE FCGR2B STAT3 RAB9B IRF3 MAPK10 IRF7 CSNK2A1 TLR7 RAB9A RIGI EIF2S1 TP73 IL1B HEL-S-72p PIK3R3 PIK3R2 PIK3R1 MAVS IL6 TRAF3 BAK1 BAD BAX NFKB2 CASP9 CCND3 CDKN1B CCNE1 CASP3 ADAR CCND2 HSPA2 FOS LACTATE SHUTTLE IN GLIAL CELLS%WIKIPATHWAYS_20260510%WP5314%HOMO SAPIENS Lactate shuttle in glial cells LDHB HEL-76 CA4 SLC16A7 NUDT14 SLC4A4 SLC1A2 HEL-S-133P SLC16A3 SLC2A3 SUDDEN INFANT DEATH SYNDROME SIDS SUSCEPTIBILITY PATHWAYS%WIKIPATHWAYS_20260510%WP706%HOMO SAPIENS Sudden infant death syndrome SIDS susceptibility pathways CREB1 REST IL1RN EP300 TPH2 HTR2A 5HT1A IL1A HDAC9 HES1 SNAP25 FOXM1 YBX1 CHRNA7 SP1 DDC CTNNB1 TH MAOA VAMP2 SST JUN CHRNB4 HDAC1 MEF2C SLC9A3 SLC1A3 EGR1 SSTR2 NKX3-1 HEL-S-87p NFKB1 CHRM2 C4A HEL-S-162eP SCN4B HEL2 CEBPB GJA1 CHRNB2 NGF RET GRIN1 PRKAR1B PRKAR1A TPH1 MAP2 ChAT HES5 FEV C4B_2 NR3C1 IL13 IL10 AVP CREBBP RORA NR3A2 G6PC1 PAH CPT1A ASCL1 GNB3 IL6R TLX3 TF RYR2 NKX2-2 GATA3 HIF1A AQP4 SOX2 ACADM EN1 LMX1B RUNX3 YWHAQ HEL-S-1 YWHAG YWHAZ POU5F1 CAV3 HADHB DLX2 TACR1 GATA2 NTRK2 GCK VIPR2 PKNOX1 TSPYL1 PBX1 POU3F2 ADCYAP1R1 TCF3 BHLHB2 DEAF1 SCN3B TP73 SPTBN1 PHOX2B PHOX2A CTCF IL1B CC2D1A HEL-S-125m SCN5A SNTA1 NOS1AP SLC25A4 HSPD1 POU2F2 KCNJ8 NFYA GPD1L NEUROD1 CREM TNF BDNF PPARGC1B IL6 CXCL8 ECE1 VEGFA NFKB2 CASP3 FREP1 NR1A2 SP3 MYB PPARGC1A EDA SIGNALING IN HAIR FOLLICLE DEVELOPMENT%WIKIPATHWAYS_20260510%WP3930%HOMO SAPIENS EDA signaling in hair follicle development LTB EDAR WNT3 RELB SHH PTCH1 DKK1 DKK4 EDARADD TNLG7C BMP1 SOSTDC1 INTEGRIN MEDIATED CELL ADHESION%WIKIPATHWAYS_20260510%WP185%HOMO SAPIENS Integrin mediated cell adhesion MAP2K3 MAPK12 MAP2K5 ITGA4 HEL-S-28 VAV3 BRAF AKT3 MYPN HRAS TLN1 MAP2K2 ITGB6 SOS1 CAPN10 PDPK1 PXN SHC1 SRC CAV3 ITGB3 CRK CAV2 ITGA6 SHC3 ITGB5 ITGAE ITGAV ITGB8 PAK6 ITGA7 ITGA2B CAPN3 PAK4 MAPK10 ITGB1 FYN GRB2 VAV2 RAC3 ITGA1 RAPGEF1 MAPK7 RHO ARAF HEL114 ITGAM ARHGEF7 MAPK1 DOCK1 RAC1 RAF1 ROCK1 ROCK2 ITGA2 ITGB7 MAP2K6 MYLK2 CAPN9 CAPNS1 CDC42 CAPN6 ITGAX CSK CAPN7 PIK3R2 CAPN5 MAPK6 TNS1 PAK1 MAPK4 VASP GIT2 CAPN11 ZYX RAP1A ITGB4 MAP2K1 SELENOP ASPIRIN AND MIRNAS%WIKIPATHWAYS_20260510%WP4707%HOMO SAPIENS Aspirin and miRNAs VEGFA WNT1 PTGS2 NFKB1 MVD PTGS1 NR1C1 GABA AND GLUTAMATE SIGNALLING IN EPILEPTOGENESIS%WIKIPATHWAYS_20260510%WP5600%HOMO SAPIENS GABA and glutamate signalling in epileptogenesis GABRA3 MAPK3 ARHGEF9 PPP2CA AP2A1 AP2A2 PIG59 SH3GL2 HDAC1 GRIN3B GRIN3A SLC1A3 ARC GLS2 ABAT SLC6A13 MAPK1 HEL-S-162eP SLC6A8 PDIA2 GRIA2 PRKCA HOMER1 GRIN2B SUMO1 GRIN1 SLC1A1 DLG4 SLC1A2 MBD5 GRIA4 ORAI1 GRIK5 GRIK3 GRIK1 SLC7A11 GRIP1 PLCB1 CACNG2 CREBBP GRM2 STAT1 DKFZp762B153 SLC6A1 GRM4 GRM6 SLC32A1 GRM8 GAD1 FFAR1 SLC6A11 SDCBP CACNG8 NRG1 EFNB2 SRC CAMK2A CRTC1 CDH2 STAT3 GRIA3 GNA11 STIM1 GRIK2 GABRG3 GRM3 NRXN3 GABRG2 GABRG1 GABRB3 GABRB2 ERBB4 GABRB1 FRMPD3 ADARB1 SLC6A12 NETO2 CPEB3 CABIN1 GABRR3 GABRR1 NPTN ADIJ DLGAP3 ADII GABRE PICK1 NWD1 GABRQ HDAC10 SNX27 GABRA2 ATAD1 GABRP SLC12A5 SYVN1 GABRA6 LHFPL4 MAP2K1 GABRA5 SNX14 GABRA4 FRAGILE X SYNDROME%WIKIPATHWAYS_20260510%WP4549%HOMO SAPIENS Fragile X syndrome ARHGAP32 CREB1 KCNC1 DUSP3 KCND2 SHANK1 ALDH5A1 TBC1D7 EPS8L1 PTPN5 FMR1 DAG1 PLCG1 EIF4G1 CNR1 BRAF PPP2R5B CYFIP2 AP2A1 ARC CDKN2A ABAT MAPK1 RAF1 RAP1GAP GRIA2 APP EEF1A1 SYNGAP1 PRKCA DICER1 AGO2 HOMER1 TARBP2 GRIN2B GRIN1 DLG4 HCN1 PRKAR1A GRIP1 ALDH3A2 PLCB1 PTEN DKFZp762B153 RPTOR RPS6KB1 DEPTOR SLC6A1 AP2S1 AP2M1 CPT1A PPP3CA GAD1 MLST8 MAP2K2 TSC2 GPHN TSC1 TTI1 AKT1S1 EPHA4 ABCD3 CLTC CLTB SOS1 CLTA CLTCL1 SHC1 SRC CAMK2A NTRK2 FYN MTOR RHEB KRAS GRB2 ARAF CAMK4 CAMK1 GABRG2 MMP9 BDNF AKAP5 GABRB2 SH3GL3 AGAP2 PTPN11 NF1 EIF4E DLGAP3 PICK1 MAP1B MAP2K1 EIF4A1 SH3GL1 CYFIP1 GRIP2 EIF4EBP2 ENTEROCYTE CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260510%WP5333%HOMO SAPIENS Enterocyte cholesterol metabolism MSMO1 TM7SF2 CD36 LBR ABCA1 ABCG8 ABCG5 DHCR7 DGAT1 APOA4 LDLR SLC27A4 HMGCS1 SAR1B MTTP HSD17B7 EBP NPC1L1 HMGCR IDI1 SC5D MGAT1 FDPS MVK APOB ACAT2 DHCR24 FABP2 SQLE PMVK MVD FDFT1 CYP51A1 LNCRNA LIKE NMRK2 IN TRANSLOCATION RENAL CELL CARCINOMA%WIKIPATHWAYS_20260510%WP5519%HOMO SAPIENS LncRNA like NMRK2 in translocation renal cell carcinoma MDH2 NONO NMRK2 SLC19A2 FH CS SIGNALING LIPIDS%WIKIPATHWAYS_20260510%WP5584%HOMO SAPIENS Signaling lipids CYP7A1 CYP8B1 GPX4 ALOX15 PRXL2B CYP2B6 HPGD PTGS2 CYP4F2 PLA2G1B CYP2C9 PTGES LTC4S CYP2C8 PLCB1 CYP7B1 CYP27A1 FADS2 ALOX5 EPHX2 PLA1A ALOX12 LUNG FIBROSIS%WIKIPATHWAYS_20260510%WP3624%HOMO SAPIENS Lung fibrosis CSF2 FAM13A HMOX1 SFTPC RTEL1 IL13 SFTPA2 IL12B DPP9 STN1 MUC5B TIMP1 PTX3 TGFB1 SFTPA1 CCL5 FGF2 CCL4 CCL3 CCL2 FGF7 SKIL IL4 KPG_011 TGFA GREM1 IGF1 CCR3 EGF CSF3 HGF PDGFA CCR2 CCL11 IL1B ELMOD2 CMA1 CXCL2 MMP2 MMP9 BMP7 SERPINA1 TNF CEBPB CTGF IL6 SPP1 ATP11A TERT EDN1 CXCL8 MT2A CALCA NFE2L2 IL5 ATR SIGNALING%WIKIPATHWAYS_20260510%WP3875%HOMO SAPIENS ATR signaling RPA3 CHEK1 HUS1 ATR RAD9B RAD1 RPA1 ATRIP RAD9A TOPBP1 17P13 3 YWHAE COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5376%HOMO SAPIENS 17p13 3 YWHAE copy number variation HEL2 PPP2CA DCTN6 DDC DCTN5 TH DISC1 DCTN1 DCTN4 HEL-S-77 PAFAH1B1 YWHAQ CDK5 HEL-S-1 YWHAG YWHAZ DCTN3 NDEL1 DBH DYNC1H1 HEMATOPOIETIC STEM CELL DIFFERENTIATION%WIKIPATHWAYS_20260510%WP2849%HOMO SAPIENS Hematopoietic stem cell differentiation CSF2 CSF1 HES6 IL1A ACVR1B NCKAP1L IKZF1 TPO TRAF3IP3 LYL1 HMGN5 TRIM29 CXCR4 CBFA2T3 ZNF835 ABO MUC1 MXI1 EPO NFE2 RUNX1 RIOK3 XB FLI1 KITLG ARHH FOSB GP9 IL3 CD34 LMO2 GATA1 PIM1 LEF1 ITGB3 GATA2 ITGA2B NFATC2 CSF3 SPI1 IL1B VAV1 IL6 NOTCH1 MHC2TA NR1A2 KLF1 MYB IL5 FOS ENERGY METABOLISM%WIKIPATHWAYS_20260510%WP1541%HOMO SAPIENS Energy metabolism CREB1 EP300 ESRRA PRKAA2 NRF1 CAMK2G GABPA TFAM PPARG FOXO3A MEF2D PPP3R2 NR1C2 CAMK4 PPP3CC NCOA1 MED1 PRKAB2 MAPK14 PRKAB1 PPP3CA NR1C1 PPP3R1 PPARGC1B TFB1M RXRA PRMT1 UCP2 TFB2M SIRT1 PRKAG1 PPRC1 PRKAG2 SIRT3 MYBBP1A PRKAA1 PRKAG3 UCP3 GSK3B HDAC1 FOXO1 ATF2 PPARGC1A MEF2C MEF2B 22Q11 2 DISTAL CNV%WIKIPATHWAYS_20260510%WP5546%HOMO SAPIENS 22q11 2 distal CNV CHEK1 RBX1 WDR57 PTPA CANX DHX16 RNF19B SNRPA1 RPS15 RPS14 SF3B5 VPREB1 SF3B2 RPS17 RPS16 RPS19 RPS18 CWC22 ROPN1L RPS11 RPS10 RPS13 SNRPB2 RSPH6A BCR SF3B1 RPS9 AQR SF3A1 RPS7 SF3A2 RPS8 RPS5 PHF5A DNAJB13 RPSA CRNKL1 PDIA4 RAB36 DNAJB11 PPIE DYDC1 SNRNP200 UBA6 CABP1 AK8 CD79B SDF2L1 CWC15 TDRD3 RPS26 RPS28 RPS29 RSPH14 RPS20 HYOU1 RPS21 RPS24 RPS23 GGTLC2 ZNF280A IQUB MAPK1 HEL-S-107 ARIH1 CCDC116 BUD31 PLRG1 NME5 YDJC RBM22 RSPH9 PPM1F RNF113A RPS15A RPS3 RPS2 RPS27A RILP PDIA2 UGGT1 PPIL1 SOX9 CDC5L RSPH3 IGLL5 XAB2 IGLL1 YPEL1 FAU PPIL4 PPIL6 UBE3A XBP1 GNAZ ELOC PARK2 RPS6 CD79A PPIB CAMK2A CBL HEL-S-99n MDM2 HEL-S-125m HEL-S-89n CAMK4 CAMK1 SNRPD2 SNRPD1 SNRPD3 PAK1 NEDD4 SNW1 SNRPG SNRPE SNRPF LRP4 SNRPB PRPF8 ALZHEIMER 39 S DISEASE%WIKIPATHWAYS_20260510%WP5124%HOMO SAPIENS Alzheimer 39 s disease CSF1 CSNK1A1L RELA MAPK9 MAPK8 IL1A MAPK3 BRAF PSEN2 AMBRA1 CTNNB1 PLCB4 LPL PIK3CA HEL-S-61 WNT2B FZD10 WNT5B WNT16 SFRP4 APC2 WNT3 WNT10B WNT10A FZD3 FZD2 FZD5 WNT3A WNT7B FZD7 FZD9 WNT7A HEL-S-162eP FZD8 APP PSMD9 PSMD6 PSMD4 PSMD3 GRIN2B PSMD1 GRIN1 ADAM10 VDAC3 NRBF2 ATG2B IDE BACE1 PSMA2 KNS2 ADAM17 PSMA8 PSMB6 PSMB2 PSMB3 PSMC1 HEL-S-276 RTN3 GPR83 KLC4 KLC3 KLC2 NAE1 ATP2A1 SLC25A6 BECN2 ADRM1 SLC25A31 PIK3CD ULK1 AKT3 PPP3CA HRAS TUBAL3 ATG101 TUBB8 TUBA3E MAP2K2 TUBA1C TUBB6 TUBA1B TUBA1A AXIN2 TUBB1 TUBB TUBB4B TUBB4A ULK2 TUBA4A FRAT1 TUBB2A DVL1 DVL2 DVL3 TUBA2 RB1CC1 AXIN1 LRP5 TUBA8 CSNK1E PSEN1 LRP6 WNT1 EIF2AK2 CSNK1A1 INSR MTOR CSNK2A1 APC NOS2 KRAS EIF2S1 CDK5 PSENEN IL1B CALML6 ARAF KIF5A CALML3 CALML4 SNCA CDK5R1 DKK4 APOE PIK3R3 PPIF PIK3R2 PIK3R1 NRAS RTN4 BAD NOX4 CHRNA7 WIPI1 WIPI2 ATG14 DKK1 ATG2A PSMD2 SHFM1 WNT4 IRS4 PSMD7 PSMD12 PSMD13 IKBKB FRAT2 CHUK MAPK1 RAF1 NFKB1 TRAF2 PTGS2 IRS1 TNFRSF1A PIK3R4 XBP1 INS APAF1 ITPR2 CACNA1C CASP8 CSNK2A3 FADD CSNK2A2 HSD17B10 DKK2 CACNA1S PLCB1 HEL-S-91n CSNK2B PPP3R2 CYBB FAS AGER CYCS PSMC6 PSMC4 CALM1 CACNA1F ATP2A2 RYR3 MME APH1B PLCB3 DDIT3 SLC25A5 MAPK10 FZD1 PPP3CC SLC25A4 PLCB2 ATF4 PPP3R1 TNF IL6 GSK3B MCU CASP9 PSMA4 CASP12 CASP3 MAP3K5 MAP2K1 ERN1 TRANS SULFURATION PATHWAY%WIKIPATHWAYS_20260510%WP2333%HOMO SAPIENS Trans sulfuration pathway pcap CBS MTR CTH GCLM APOPTOSIS RELATED NETWORK DUE TO ALTERED NOTCH3 IN OVARIAN CANCER%WIKIPATHWAYS_20260510%WP2864%HOMO SAPIENS Apoptosis related network due to altered Notch3 in ovarian cancer RIPK2 YBX3 HEL-S-7 PKN1 CDKN1A BIRC5 BEX3 TRAF1 SQSTM1 CUL5 RNF7 VAV3 JUND NET1 PTK2B CARD14 HEL-S-89n RPS6KB1 NQO1 HEL113 HSPD1 MAPK1 THBS1 HELLS NFKB1 TNFRSF21 APOE CTNNA1 TNF TNFRSF10B SOCS3 F2R APP NRG1 CDKN1B HDAC1 AXIN1 IL7R GCLC HEL-S-102 ERBB3 ERN1 MIR 509 3P ALTERATION OF YAP1 ECM AXIS%WIKIPATHWAYS_20260510%WP3967%HOMO SAPIENS miR 509 3p alteration of YAP1 ECM axis YAP1 EDNRA TEAD2 TEAD3 TEAD4 COL1A1 COL3A1 PBX3 THBS2 GPC6 TWIST1 SPARC SNAI2 METABOLIC PATHWAY OF LDL HDL AND TG INCLUDING DISEASES%WIKIPATHWAYS_20260510%WP4522%HOMO SAPIENS Metabolic pathway of LDL HDL and TG including diseases APOE ABCA1 SCARB1 LIPC ANXA2 LPL LDLR MTTP APOB PCSK9 APOA2 APOC2 LIPG IL26 SIGNALING%WIKIPATHWAYS_20260510%WP5347%HOMO SAPIENS IL26 signaling CTSK STAT3 CSF2 RELA MAPK9 MAPK8 IL10 MAPK3 JAK1 RORC IL1B NFKBIA STAT1 EPHA3 IF2G MAPK1 MAPK14 SMAD2 CCL20 DCSTAMP IL33 DEFB4B IL20RA ATP6V0D2 IL10RB TYK2 MMP9 TNF TNFSF11 IL6 SOCS3 COX2 NFATC1 CXCL8 JUN BAX PIK3CA MPO IL17A CASP3 DDIT3 ACTA2 MYD88 DISTINCT INPUT OUTPUT PATHWAY%WIKIPATHWAYS_20260510%WP3877%HOMO SAPIENS MYD88 distinct input output pathway TLR4 TLR7 MYD88 HEL-S-71 IL1A JUN UBE2V1 TLR8 TLR5 TRAF6 TLR1 NFKB1 IRAK1 TIFA TLR10 TLR9 BIOMARKERS FOR UREA CYCLE DISORDERS%WIKIPATHWAYS_20260510%WP4583%HOMO SAPIENS Biomarkers for urea cycle disorders ASL NAGS F10 OTC HEL-S-20 GLS2 GPT ARG1 ASS1 F7 ANK2 PATHWAY IN EPILEPSY DEVELOPMENT%WIKIPATHWAYS_20260510%WP5557%HOMO SAPIENS ANK2 pathway in epilepsy development ANK2 L1CAM EIF2A CSNK2A1 SEMA3A KCNQ2 CSNK2A2 CSNK2B SCN5A SPTAN1 DDIT3 SNAP25 PRRT2 SPTBN4 SCN2A ATF4 BRSK1 CHRONIC HYPERGLYCEMIA IMPAIRMENT OF NEURON FUNCTION%WIKIPATHWAYS_20260510%WP5283%HOMO SAPIENS Chronic hyperglycemia impairment of neuron function MMP7 PRKCZ NOS2 MMP14 HEL-S-62p SNAP25 AGER MMP2 PRKD3 SCN8A MMP9 BDNF MMP21 MMP20 MMP25 MMP24 TRPA1 MMP23B MMP27 SCN9A TRPV1 MMP10 MMP11 SLC2A3 SCN10A MMP16 MMP15 MMP17 MMP19 PRKCH PRKCB PRKCE PRKCA MMP28 PRKCI MMP3 SORD MMP12 PRKCQ INITIATION OF TRANSCRIPTION AND TRANSLATION ELONGATION AT THE HIV 1 LTR%WIKIPATHWAYS_20260510%WP3414%HOMO SAPIENS Initiation of transcription and translation elongation at the HIV 1 LTR NFATC2 EP300 NELFB NELFCD RELA CDK9 SUPT5H HDAC7 HDAC3 HDAC9 PPP3R2 CREBBP NFKBIA PPP3CC PPP3CA NFKB1 HDAC5 SP1 PPP3R1 HDAC8 NFATC1 SUPT4H1 NELFA HEXIM1 HDAC2 NFATC3 HDAC1 NFATC4 CELLULAR PROTEOSTASIS%WIKIPATHWAYS_20260510%WP4918%HOMO SAPIENS Cellular proteostasis VBP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 NSP1 FROM SARS COV 2 INHIBITS TRANSLATION INITIATION IN THE HOST CELL%WIKIPATHWAYS_20260510%WP5027%HOMO SAPIENS nsp1 from SARS CoV 2 inhibits translation initiation in the host cell EIF3CL EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B EIF2S2 EIF2S1 EIF1AX SUI1 EIF5 EIF2S3 EIF3S2 EIF3J EIF3S3 EIF3G DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260510%WP707%HOMO SAPIENS DNA damage response CREB1 CHEK1 MRE11A NBN APAF1 BBC3 CASP8 CCNE2 RFC1 SFN RAD9A CDKN1A PRKDC CCNB3 CCNB2 CCNB1 CCND1 MYC FAS CYCS CDC2 CDK2 FANCD2 ATR TLK1 TNFRSF10B TP53AIP1 SMC1A ATRIP RAD17 RAD1 RB1 PML HUS1B BRCA1 PIDD1 MDM2 TLK2 CDK5 CDK6 CDK4 RRM2B DDB2 SESN1 GADD45B PMAIP1 GADD45A GADD45G BAX H2AX CASP9 RAD52 CCND3 CDKN1B CCNE1 CASP3 ATM CCND2 RAD50 CHEK2 RAD51 INTERACTOME OF POLYCOMB REPRESSIVE COMPLEX 2 PRC2 %WIKIPATHWAYS_20260510%WP2916%HOMO SAPIENS Interactome of polycomb repressive complex 2 PRC2 AEBP2 SUZ12 EZH1 EED MORC3 ELL SETX THRAP3 STK38 TRIM35 JARID2 EZH2 BCLAF1 RBBP7 RBBP4 METHIONINE DE NOVO AND SALVAGE PATHWAY%WIKIPATHWAYS_20260510%WP3580%HOMO SAPIENS Methionine de novo and salvage pathway MTR IL4I1 HEL-S-61p AMD1 APIP MRI1 TXN MAT1A MTAP ADI1 ENOPH1 MSRA MSRB2 CHDH MSRB3 SRM SMS FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20260510%WP357%HOMO SAPIENS Fatty acid biosynthesis PC ACACA DECR1 ECHS1 ACSL1 FACL4 ACSS2 PECR ACSL3 MECR SCD ACACB FASN ECHDC1 ECHDC2 ACSL6 ACSL5 ACLY INTERFERON TYPE I SIGNALING%WIKIPATHWAYS_20260510%WP585%HOMO SAPIENS Interferon type I signaling ZAP70 CREB1 EIF4B MAP2K3 GAB2 JAK1 PIK3CD STAT1 RPS6 RPTOR RPS6KB1 MAPK14 SOCS1 STAT4 MLST8 TYK2 LCK PTPRC PRMT1 SOCS3 CRKL CRK RPS6KA4 CBL EIF4EBP1 IRF9 STAT3 FYN MTOR PTPN6 REL RAPGEF1 RPS6KA5 VAV1 MAP3K1 RAC1 MAP2K6 IFNAR2 PIK3R2 PIK3R1 IFNAR1 MAPKAP1 PTPN11 STAT2 RAP1A EIF4E IRS1 EIF4A1 PIAS1 NUCLEOSOME REMODELING COMPLEX%WIKIPATHWAYS_20260510%WP5572%HOMO SAPIENS Nucleosome remodeling complex SMIM40 PRKDC CHAF1A XRCC5 MCM2 PCNA H4C9 HAT1 SUPT16H HIST1H4L SSRP1 CHAF1B ASF1A NASP ASF1B RBBP4 CHEK2 SEROTONIN RECEPTOR 4 6 7 AND NR3C SIGNALING%WIKIPATHWAYS_20260510%WP734%HOMO SAPIENS Serotonin receptor 4 6 7 and NR3C signaling CREB1 MAP2K2 EGR1 MAPKAPK2 NR3C1 ATF1 RAP1A MAPK3 RPS6KA5 BRAF HTR4 MAPK1 HTR6 HTR7 MAP2K1 GNAS NF1 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260510%WP5366%HOMO SAPIENS NF1 copy number variation syndrome MCL1 EXOC4 EXOC3 EXOC6 H3C15 EXOC5 CCNE2 SUPT5H EXOC2 RFC2 EXOC1 RAD9A RAB11A MAPK3 ARF6 ARHA BCL2 ATR CRY1 TUBB CCNA2 USP1 OMG SOS1 RTN4R PER1 HEL-S-15 PCNA EGFR NGFR SUZ12 EGF EIF3A EED RIGI RFC3 RFC4 MAP3K2 JARID2 SYN1 RBBP7 MAP3K1 H4C9 MAPK1 RAF1 HIST1H4L ROCK2 EXOC7 WDR48 HOXA9 HOXA1 POLRMT MYT1 EVL EZH1 SDC2 ADAP2 MAVS INPP5A E2F6 LIMK1 RAB11FIP4 TEFM UTP6 ATAD5 COPRS EVI2A IFNB1 CRLF3 NGF EVI2B NF1 METAP2 CCNE1 EXOC8 H3C8 RAD51 SYNAPTIC VESICLE PATHWAY%WIKIPATHWAYS_20260510%WP2267%HOMO SAPIENS Synaptic vesicle pathway SLC1A3 CACNA1B CACNA1A HEL-S-67p SLC17A6 SLC17A7 SLC18A3 SYN1 SLC25A4 NAPA AP2S1 SNAP25 AP2M1 UNC13A SLC32A1 SYT1 STXBP1 SYP STX1A CPLX1 STX1B RIMS1 SLC18A2 VAMP2 AP2A1 CLTC AP2A2 SLC38A1 CLTA SLC22A3 CLTCL1 CPLX2 CLN8 SLC17A8 STX2 SLC18A1 UNC13B UNC13C SYN2 STX3A DNM3 STRIATED MUSCLE CONTRACTION PATHWAY%WIKIPATHWAYS_20260510%WP383%HOMO SAPIENS Striated muscle contraction pathway TNNI1 TNNI2 TCAP TNNI3 TNNC2 TPM3 HEL-S-108 TNNT3 MYH8 TNNT1 TNNC1 HEL113 ACTN2 TTN ACTG1 MYL1 tmp_locus_29 ACTN4 MYL3 MYH6 TPM1 DMD ACTA1 MYOM1 MYBPC3 MYL2 TMOD1 ACTA2 MYL4 HEL-S-273 KYNURENINE PATHWAY AND LINKS TO CELL SENESCENCE%WIKIPATHWAYS_20260510%WP5044%HOMO SAPIENS Kynurenine pathway and links to cell senescence IFNG AADAT TNF HAAO TLR4 IDO1 HEL-S-90n TDO2 AFMID KLF5 KYNU KMO IDO2 IFNB1 CDKN1A AHR IL1R2 FOXO1 EIF2AK1 EIF2AK4 PROLACTIN SIGNALING%WIKIPATHWAYS_20260510%WP2037%HOMO SAPIENS Prolactin signaling ZAP70 SOCS2 PRL GAB2 RELA TEC MAPK9 MAPK8 CISH JAK1 MAPK3 STAT5B STAT1 RPS6 RPS6KB1 MAPK14 MYC SOCS1 HRAS MAP2K2 SOCS3 SOS1 YWHAG YWHAZ PXN JUN PIK3CA PPIB SHC1 SRC CBL FLNA EIF4EBP1 PTPN1 STAT3 SIRPA NFKBIB ITGB1 FYN MTOR PTPN6 GRB2 VAV2 NFKBIA VAV1 MAPK1 RAC1 RAF1 PRLR NFKB1 PIK3R2 PIK3R1 PAK1 RPS6KA2 HEL-S-130P AGAP2 PTPN11 GSK3B CASP3 IRS1 MAP2K1 HEL-S-69p FOS NEK3 ERBB2 VITAMIN B12 METABOLISM%WIKIPATHWAYS_20260510%WP1533%HOMO SAPIENS Vitamin B12 metabolism SAA4 MCEE TCN2 PLG CBLIF INSR CBS TCN1 MTR HEL-S-78p ALB RELA SAA1 SAA2 HEL-S-51e PLAT CRP IL1B F2 NFKB1 CCL5 APOE CCL2 ABCA1 IFNG TNF IL6 SCARB1 HEL-S-44 LDLR HBB HBA2 MPO MAT1A NFKB2 APOB CTH SERPINA3 INS CUBN FGA MTRR F7 TYROBP CAUSAL NETWORK IN MICROGLIA%WIKIPATHWAYS_20260510%WP3945%HOMO SAPIENS TYROBP causal network in microglia CD84 NRROS FKBP15 LOXL3 PPP1R18 CD37 RNASE6 LGALS9C APBB1IP BIN2 ELF4 NCF2 SFT2D2 TMEM106A RBM47 IGSF6 KCNE3 SAMSN1 NCKAP1L HLX CYTL1 LHFPL2 HIMAP2 GAPT LYL1 TYROBP HEL-S-62p IL10RA C1QC TGFBR1 NPC2 RUNX3 TCIRG1 TNFRSF1B HCLS1 CXCL16 ZFP36L2 SH2B3 PLEK SLC7A7 CREB3L2 DPYD ITGAM IL18 HEL-S-66 ITGAX PYCARD ADAP2 RPS6KA1 SPP1 RGS1 IL13RA1 GPX1 GAL3ST4 MAF VEGFA VEGFR2 SIGNALING%WIKIPATHWAYS_20260510%WP3888%HOMO SAPIENS VEGFA VEGFR2 signaling CREB1 MAP2K3 AMOT PRKAA2 RELA ACACA MAPK9 MAPK8 PLCG1 LDB2 HDAC9 MAPK3 DLL4 CALU ARF6 NAPA MAPK14 ARHA IGFBP7 XB BCL2 CTNNB1 ACTG1 INPP4B tal-1 ACOT9 AP2A1 PFN1 HBD EZR JUN PXN IQGAP1 PIK3CA HEL-S-15 RPS11 HEL-S-102 BRD4 SLC25A11 SDF2L1 TMSB4X TXN HYOU1 HEL-S-87p HEL-S-133P ROCK1 ROCK2 HEL-S-128m HEL-S-68p HEL-S-162eP CDC42 CSK WASF1 LIMK1 SLC2A14 RAP1A FHL2 PSMD4 ADAM10 ELOC ADAM9 FHOD1 HEL-S-2a RAB11A FLT1 RAB5A CCND1 FLII PPP3CA KDR MLST8 HRAS AFDN GPC1 TUBB8 MAP2K2 CCL2 EIF2A TUBA1C SDCBP MMP10 AKT1S1 CLTC NFATC1 ACKR3 EPHA2 NCL SHC1 SRC ITGB3 FOXO1 CACNA2D1 MYL2 ITGAV NFATC2 STAT3 EIF3F FYN MTOR EIF3D EPRS1 PTPN6 MOV10 MDM2 GRB2 VAV2 BIRC5 RPS6KA5 HEL114 PNP OCRL VPS39 RAC1 MMP2 SELE TNFRSF25 SHC2 CTNNA1 PIK3R2 PIK3R1 PAK1 PTPN11 TBCA ARF4 PTMAP7 TMOD1 NOX4 SH3BGRL3 SYNJ1 EPHB2 CYR61 ANXA1 MAPKAPK2 HEL107 SRPK1 GLUD1 EIF4G1 HLX RPL5 TRPC1 TRAF3IP2 RPL7 RPL18A LUC7L UBAP2L CHAC1 SRP54 ATP6V1E1 IER5 TMEM170A SND1 PPP2CA KATNAL2 EWSR1 BIN1 TXNIP RPL27 RPL26 CDC42BPB ATP6V0D1 SH2D2A DKK1 GIGYF2 LMAN1 FXR2 DHX36 SIAH2 BMP2 MICAL2 FBXW11 PRRC2C LARP7 DHX29 PPM1G FARSB NRP2 KCNC3 CCDC124 HDAC1 SHB EEA1 RPLP2 ELOA CLIC1 ATF2 CGNL1 ITGB5 DUSP5 SSR4 MEF2C SSR3 FJX1 KANK1 CNP PTPN1 PRKD2 CRIP2 SLC7A1 SET EGR1 FAF1 APOLD1 FGD5 CCT7 TPM3 HMGB1 TAOK2 COPG1 KL CTNND1 PLOD3 RPL10A CCRL2 DECR1 TMOD3 SEMA6D DPM1 ARMCX1 HDAC7 HGS RAB37 FOXO4 GRB10 MAPKAPK5 ZNF555 NFKBIA DSC1 LRRC59 PSMD11 HTRA1 ZC3H15 MAPK1 HEL-S-94n RAF1 RAB4A HEL-S-84 TNFRSF10C NFKB1 MAP2K6 BMX TFCP2 NR4A3 HEL2 TPP1 GRSF1 CSRP2 C15orf39 BMP10 hEMMPRIN SLC8A1 NRARP CTGF RND1 CAPZB LRRFIP2 GJA1 ADAMTS9 TRPC3 ARHGEF15 PTGS2 SHROOM2 RPL13A PABPC1 HEL164 EPN1 CYP2C8 MMRN2 DNAJB4 FAM120A PRKCB DNAJB9 PRKCE AAG1 ABCF2 PRKCA SLC25A25 PDE4DIP TMSB10 FMNL3 MYO1C PTPN9 FUT1 PRKD1 MAPK12 DOK1 ADRB2 PRKCZ FADD BCL2L1 NCF1 NCF2 TFAM FOXO3A CREBBP MYO6 STAT1 RPS6 CYBB RPS6KB1 ACACB AP2S1 FAS CYCS HDAC5 ARRB2 ENG PLAUR NCK1 TEAD4 MAP2K4 P4HA2 PDPK1 MYH9 PLA2G5 PLCB3 ITCH CRK HBEGF GATA2 CBL FGA EIF3S3 HEL-S-99n FLNB PRKRA HEL-S-78p F3 ITGB1 ALB ERG RAPGEF1 MMP14 PTK2B CAMKK2 ATF4 SPIRE1 NUMB PRKG1 FRS2 PRKAA1 GPX1 MAPKAP1 QK3 RICTOR GSK3B CXCL8 EIF4E VEGFA SARS1 S1PR1 MAP3K5 PRKCI MAP2K1 ERN1 BENZO A PYRENE METABOLISM%WIKIPATHWAYS_20260510%WP696%HOMO SAPIENS Benzo a pyrene metabolism AKR1C4 AKR1C1 HEL-S-165mP EPHX1 CYP3A4 CYP1A1 AKR1C2 CYP1B1 WNT BETA CATENIN SIGNALING IN LEUKEMIA%WIKIPATHWAYS_20260510%WP3658%HOMO SAPIENS Wnt beta catenin signaling in leukemia ZBTB16 CTNNB1 PML AXIN2 BCL9 APC PYGO1 DKK1 RARA TCF3 GSK3B FLT3 JUP LEF1 NR1C2 LRP5 CCND1 LRP6 SALL4 MYC WNT1 RUNX1T1 WIF1 CSNK1A1 NEUROTRANSMITTER DISORDERS%WIKIPATHWAYS_20260510%WP4220%HOMO SAPIENS Neurotransmitter disorders PNMT SLC6A3 TPH2 DDC TH MAOA SLC18A2 DBH TPH1 FAS LIGAND PATHWAY AND STRESS INDUCTION OF HEAT SHOCK PROTEINS%WIKIPATHWAYS_20260510%WP314%HOMO SAPIENS Fas ligand pathway and stress induction of heat shock proteins APAF1 RIPK2 FAF1 CASP8 TNFSF6 PS1TP5BP1 FADD MAPKAPK3 ARHGDIB MAPKAPK2 SMIM40 MAPK8 PRKDC IL1A MAP3K1 LMNA FAS CYCS CASP10 BCL2 TNF ACTG1 PAK1 CASP6 DFFB DFFA MAP2K4 JUN CASP9 MAP3K7 SPTAN1 CASP3 RB1 ACTA1 NFX1 LMNB2 HEL-S-102 PARP1 METHYLATION PATHWAYS%WIKIPATHWAYS_20260510%WP704%HOMO SAPIENS Methylation pathways PNMT MAT1A NNMT TPMT INMT QUERCETIN AND NF KB AP 1 INDUCED APOPTOSIS%WIKIPATHWAYS_20260510%WP2435%HOMO SAPIENS Quercetin and Nf kB AP 1 induced apoptosis JUN VEGFA IKBKB NFKBIA NFE2L2 MAFG CYP2A6 MAFK PTGS2 NFKB1 FOS KEAP1 MAPK CASCADE%WIKIPATHWAYS_20260510%WP422%HOMO SAPIENS MAPK cascade MAP2 MAP2K3 MAPK12 MAPK10 KRAS GRB2 MAP3K2 MAPK3 LAMTOR3 ARAF MAP3K1 RRAS BRAF MAPK1 MAPK14 RAF1 MAP2K6 MBP HRAS MAP2K2 NRAS RASA3 SOS1 SOS2 MAP2K4 JUN PLCB3 SIPA1 MAP2K1 MAP3K12 SUZETRIGINE MECHANISM FOR PAIN RELIEF%WIKIPATHWAYS_20260510%WP5558%HOMO SAPIENS Suzetrigine mechanism for pain relief SCN10A VITAMIN B6 DEPENDENT AND RESPONSIVE DISORDERS%WIKIPATHWAYS_20260510%WP4228%HOMO SAPIENS Vitamin B6 dependent and responsive disorders ALDH7A1 PIGV PLPBP ALPI HEL-S-1a HEL-S-302 ALPL G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20260510%WP45%HOMO SAPIENS G1 to S cell cycle control CREB1 CCNE2 POLA2 CDKN1A CCNB1 ORC6 MNAT1 ORC3 CCND1 ORC2 MYC CDC2 CDK7 CDK2 CDKN1C MCM7 ORC1L TFDP1 TFDP2 MCM3 MCM5 MCM6 MCM2 PCNA RB1 CDC45 CDKN2D CDKN2B CDKN2C WEE1 POLE CDKN2A MDM2 CDK6 CCNG2 PRIM1 ATF6B CDK4 CREB3L3 CREB3L4 CREB3 RPA1 POLE2 MYT1 RPA3 E2F2 E2F3 GADD45A CCND3 CDKN1B CCNE1 ATM CCNH CCND2 PRIM2 HALLMARK OF CANCER NON MUTATIONAL EPIGENETIC REPROGRAMMING%WIKIPATHWAYS_20260510%WP5483%HOMO SAPIENS Hallmark of cancer non mutational epigenetic reprogramming CADM1 TET2 EZH2 CREBBP EP300 NOL9 HDAC2 HDAC1 PIP4K2A IRS1 IFITM3 ANKRD13C EICOSANOID METABOLISM VIA CYCLOOXYGENASES COX %WIKIPATHWAYS_20260510%WP4719%HOMO SAPIENS Eicosanoid metabolism via cyclooxygenases COX PTGDR2 PTGIS PRXL2B PPARG PTGES NR1C2 PLA2G6 PLA2G4B CYP4A11 EHHADH HEL-S-298 PTGDR HPGD PTGS2 PTGFR CYP4F2 CYP4A22 PTGS1 PTGIR PTGR1 PLA2G5 CYP4F12 TBXA2R ACOX3 ACOX1 AKR1B1 OLIGODENDROCYTE DEVELOPMENT%WIKIPATHWAYS_20260510%WP5574%HOMO SAPIENS Oligodendrocyte development MYRF NFATC2 HES5 OLIG2 PTN SOX10 ZNF24 TMEM98 DUSP15 RELN SHH ZNF488 LGI1 NKX2-6 OPALIN OLIG1 ZBTB33 ID4 CNTN1 BMP4 CHD8 SOX6 WNT10A ID2 ASCL1 MBP FGF2 PDGFRA MYT1 NKX6-1 NFIA NKX2-2 EGR2 SOX2 SMAD1 SOX9 SOX8 BMP1 SOX5 TCF7L2 SOX11 PRKCA CSPG4 ZEB2 13Q12 12 COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5406%HOMO SAPIENS 13q12 12 copy number variation MAPK9 MAPK8 DAG1 MIPEP C1QTNF9 TRAF1 ATXN1 SACS TNFRSF19 SNTA1 C1QTNF9B LINGO1 SPATA13 SSPN SNTB1 RAC1 ARHA CDC42 TRAF2 SGCD TRAF5 SGCA TRAF3 RTN4 SGCB SGCG RTN4R DMD CHOLESTEROL BIOSYNTHESIS WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260510%WP4804%HOMO SAPIENS Cholesterol biosynthesis with skeletal dysplasias EBP SC5D DHCR7 DHCR24 CYP51A1 LBR FELBAMATE METABOLISM%WIKIPATHWAYS_20260510%WP2816%HOMO SAPIENS Felbamate metabolism CYP3A4 CYP2E1 OSTEOBLAST DIFFERENTIATION AND RELATED DISEASES%WIKIPATHWAYS_20260510%WP4787%HOMO SAPIENS Osteoblast differentiation and related diseases MAPK9 MAPK8 PRKDC JAG2 DLL3 MAPK3 DLL4 MAPK14 SMAD4 FGF2 CTNNB1 FGF7 FGF8 FGF9 SMAD1 SMAD9 BMP2 DKFZp781O1323 WNT4 PIK3CA BMPR1A BMPR2 GLI3 HEY2 FGF18 IHH FGF10 WNT2B FZD10 WNT5B NOTCH3 PTCH1 WNT9B WNT9A WNT16 PPARG SMO WNT8A WNT8B WNT3 FGF7B WNT10B WNT10A FZD3 FGF7A FZD2 FZD5 FZD4 MAPK1 WNT3A WNT7B FZD7 FZD9 MAPK13 WNT7A FZD8 MAPK6 MAPK4 FGF5C SOX9 PRKCH PRKCB PRKCE PRKCA PIK3R4 PIK3C2G PIK3C2A PIK3C2B PIK3R5 PRKCQ PRKD1 MAPK12 MAPK11 PRKCZ HES6 HES3 PIK3CD MYOD1 STAT1 HES2 LRP5 RBPJ LRP6 WNT1 MAPK10 FZD1 FGFR4 RUNX2 FGFR3 BMP4 FGFR2 FGFR1 MAPK7 PIK3R3 PIK3R2 PIK3R1 NOTCH2 NOTCH1 PRKCI HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES MAPK SIGNALING%WIKIPATHWAYS_20260510%WP4877%HOMO SAPIENS Host pathogen interaction of human coronaviruses MAPK signaling RPS6KA3 MAP2K3 MAPK12 MAPK10 MAPK11 MAP3K11 MAPK9 MAPK8 MAPK3 MAP3K1 IFITM1 MAPK1 MAPK14 IFI27 RAF1 MAP2K6 MAPK13 MAP2K2 BCL2 MAP3K10 RPS6KA2 RPS6KA1 MAP2K4 EIF4E JUN JUNB DDIT3 BST2 ATF2 MAP2K1 IFITM3 FOS IFITM2 SPHINGOLIPID METABOLISM OVERVIEW%WIKIPATHWAYS_20260510%WP4725%HOMO SAPIENS Sphingolipid metabolism overview PLPP2 CERK PLPP1 SGMS1 SPHK1 SGMS2 UGT8 UGCG KDSR GBA2 CERS1 CERS2 SPHK2 SGPP2 SGPP1 SGPL1 SPTLC2 SPTLC1 SMPD1 CERS3 DEGS1 DEGS2 CERS6 PLPP3 HIPK2 IN KIDNEY FIBROSIS%WIKIPATHWAYS_20260510%WP4751%HOMO SAPIENS HIPK2 in kidney fibrosis SIAH1 HIPK2 MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20260510%WP391%HOMO SAPIENS Mitochondrial gene expression POLRMT CREB1 ESRRA HCFC1 PPARGC1B TFB1M TFB2M PPRC1 NRF1 TFAM GABPA MYEF2 CAMK4 MTERF3 PPP3CA GABPB1 MTERF1 PPARGC1A SP1 INFLAMMATORY BOWEL DISEASE SIGNALING%WIKIPATHWAYS_20260510%WP5198%HOMO SAPIENS Inflammatory bowel disease signaling STAT3 TLR4 IL2RG IL13 IL10 IL1A IF2B1 IL23R IL12A RORC TGFB1 RORA STAT1 IL-21 SMAD2 IL2 STAT4 IFNGR1 NFKB1 IL12RB1 IL18 FOXP3 IFNG TNF IL23A IL6 GATA3 HLA-DMA TBX21 IL21R NFATC1 IL4 JUN IL17F IL18RAP TLR5 NOD2 IL5 MAF GROWTH FACTORS AND HORMONES IN BETA CELL PROLIFERATION%WIKIPATHWAYS_20260510%WP5385%HOMO SAPIENS Growth factors and hormones in beta cell proliferation INSR CDK2 PDGFA PDX1 KRAS CRTC2 FLT1 CDK4 MAPK3 IGF1R BRAF FOXO1 MAPK1 RASSF1 MYC AKT3 FOXM1 INS IGF1 RAB43 TGFBR1 ALZHEIMER 39 S DISEASE AND MIRNA EFFECTS%WIKIPATHWAYS_20260510%WP2059%HOMO SAPIENS Alzheimer 39 s disease and miRNA effects CSF1 CSNK1A1L RELA MAPK9 MAPK8 IL1A MAPK3 BRAF PSEN2 AMBRA1 CTNNB1 PLCB4 LPL PIK3CA HEL-S-61 WNT2B FZD10 WNT5B WNT16 SFRP4 APC2 WNT3 WNT10B WNT10A FZD3 FZD2 FZD5 WNT3A WNT7B FZD7 FZD9 WNT7A HEL-S-162eP FZD8 APP PSMD9 PSMD6 PSMD4 PSMD3 GRIN2B PSMD1 GRIN1 ADAM10 VDAC3 NRBF2 ATG2B IDE BACE1 PSMA2 KNS2 ADAM17 PSMA8 PSMB6 PSMB2 PSMB3 PSMC1 HEL-S-276 RTN3 GPR83 KLC4 KLC3 KLC2 NAE1 ATP2A1 SLC25A6 BECN2 ADRM1 SLC25A31 PIK3CD ULK1 AKT3 PPP3CA HRAS TUBAL3 ATG101 TUBB8 TUBA3E MAP2K2 TUBA1C TUBB6 TUBA1B TUBA1A AXIN2 TUBB1 TUBB TUBB4B TUBB4A ULK2 TUBA4A FRAT1 TUBB2A DVL1 DVL2 DVL3 TUBA2 RB1CC1 AXIN1 LRP5 TUBA8 CSNK1E PSEN1 LRP6 WNT1 EIF2AK2 CSNK1A1 INSR MTOR CSNK2A1 APC NOS2 KRAS EIF2S1 CDK5 PSENEN IL1B CALML6 ARAF KIF5A CALML3 CALML4 SNCA CDK5R1 DKK4 APOE PIK3R3 PPIF PIK3R2 PIK3R1 NRAS RTN4 BAD NOX4 CHRNA7 WIPI1 WIPI2 ATG14 DKK1 ATG2A PSMD2 SHFM1 WNT4 IRS4 PSMD7 PSMD12 PSMD13 IKBKB FRAT2 CHUK MAPK1 RAF1 NFKB1 TRAF2 PTGS2 IRS1 TNFRSF1A PIK3R4 XBP1 INS APAF1 ITPR2 CACNA1C CASP8 CSNK2A3 FADD CSNK2A2 HSD17B10 DKK2 CACNA1S PLCB1 HEL-S-91n CSNK2B PPP3R2 CYBB FAS AGER CYCS PSMC6 PSMC4 CALM1 CACNA1F ATP2A2 RYR3 MME APH1B PLCB3 DDIT3 SLC25A5 MAPK10 FZD1 PPP3CC SLC25A4 PLCB2 ATF4 PPP3R1 TNF IL6 GSK3B MCU CASP9 PSMA4 CASP12 CASP3 MAP3K5 MAP2K1 ERN1 NAD METABOLISM SIRTUINS AND AGING%WIKIPATHWAYS_20260510%WP3630%HOMO SAPIENS NAD metabolism sirtuins and aging ROS1 SIRT1 HIF1A FOXO1 SIRT3 NAMPT PARP1 NFKB1 TFAM PPARG FOXO3A 3Q29 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP4906%HOMO SAPIENS 3q29 copy number variation syndrome DYNLL2 NRROS DNCL1 STAT5B TGFB1 RNF168 MYC RNF8 TFRC UBXN7 SMCO1 MFI2 MYCBP2 NCBP1 FBXO45 TF NCBP2 ZDHHC19 BRINP1 TM4SF19 HIF1A CEP350 PIGX FBXW7 MCRS1 MAD2L1BP WDR53 ZNF76 PIGM SLC51A PXN JUN SLC51B DYNC2I2 SLC40A1 CEP19 HFE HEL-S-71 H2BC21 DYNC2H1 DYNLT1 FNDC8 PIK3R3 SIRT1 DYNLT2B DYNLRB2 DYNC2LI1 NF2 ADAM10 RABL2B DYNLT3 HAMP CYTOPLASMIC RIBOSOMAL PROTEINS%WIKIPATHWAYS_20260510%WP477%HOMO SAPIENS Cytoplasmic ribosomal proteins RPS6KA3 RPS6 RPS6KB1 RPL5 RPS6KB2 RPL7 RPL18A RPL27 RPL26 RPS15 HEL-S-310 RPS14 RPL4 RPL11 RPL3 RPS17 RPL32 RPS16 RPL31 RPS19 RPLP1 RPS18 RPL34 RPLP0 RPL8 RPS11 RPL9 RPS10 RPL6 RPS13 RPS4X RPL7A RPLP2 RPS9 RPL36 RPL35 RPS7 RPL38 RPS8 RPL37 RPS5 RPL39 RPL21 RPSA RPL22 RPS3A RPL37A RPL29 RPL28 RPL10 RPL12 MRPL19 RPL36A RPS4Y1 RPL14 RPL10A RPL13 RPL15 RPL18 RPL17 RPS26 RPL19 RPS28 RPL41 RPS29 RPL35A RPL23A RPS20 RPL3L RPS25 RPS21 RPS27 RPS24 RPL27A RPS23 RPL23 RPL30 RPS15A RPS3 RPS6KA6 RPS2 RPS6KA2 RPS6KA1 RPS27A RPL13A FAU FOCAL ADHESION%WIKIPATHWAYS_20260510%WP306%HOMO SAPIENS Focal adhesion RASGRF1 MAPK9 MAPK8 MYLK3 TNK2 MAPK3 BRAF ARHA ARHGAP35 TLN1 MYLK BCL2 XB ACTG1 CTNNB1 VWF ACTN1 PXN JUN PIK3CA TNC PIP5K1C VEGFC LAMC1 ITGB5 IGF1 FLNA PPP1CC ITGB8 ITGA7 ITGA2B PS1TP5BP1 RAC3 ITGA1 VAV1 MAPK1 DOCK1 RAF1 ROCK1 c-fgr ROCK2 VEGFB CDC42 VEGFD IBSP SPP1 MYL12B COL4A1 COL4A4 COL4A6 RAP1A COL1A1 PRKCB COL2A1 PRKCA LAMC2 LAMA1 ERBB2 LAMA4 LAMA3 MYL11 LAMB3 LAMB2 LAMB1 RELN VTN HEL-S-80p FLT1 ITGA4 PTEN HEL-S-28 PIK3CD VAV3 IGF1R THBS2 CCND1 AKT3 KDR HRAS PDGFRA ITGB6 CRKL COL1A2 ACTN4 SOS1 MET PDPK1 PARVA SHC1 SRC CAV3 CAV2 ITGB3 CRK EGFR SHC4 ITGA6 SHC3 MYL2 ITGAV PAK6 FLNB PAK4 EGF MAPK10 ITGB1 FYN PDGFD LAMA5 HGF PDGFC PDGFA GRB2 VAV2 COL4A2 RAPGEF1 BIRC3 HEL114 MYLK4 COMP TNR MYL5 THBS1 MYL7 RAC1 TLN2 BLK ITGA2 TXK ITGB7 MYLK2 MYL12A CHAD SHC2 MYL10 PIK3R3 SRMS PIK3R2 TNK1 PIK3R1 PTK6 PARVB VASP PARVG PAK1 COL5A3 COL5A2 ARHGAP5 BIRC2 ZYX EMP2 PPP1R12B PPP1R12C BAD THBS4 THBS3 STYK1 GSK3B VEGFA ITGB4 CCND3 MAP2K1 CCND2 OLIGODENDROCYTE SPECIFICATION AND DIFFERENTIATION LEADING TO MYELIN COMPONENTS FOR CNS%WIKIPATHWAYS_20260510%WP4304%HOMO SAPIENS Oligodendrocyte specification and differentiation leading to myelin components for CNS CNP OLIG2 SOX10 SHH NKX2-6 OLIG1 BMP4 MOG IL1B SOX6 CXCL1 ASCL1 CXCL2 MBP FGF2 MYT1 TNF NKX2-2 SOX9 OMG SOX8 BMP2 SOX5 LIF CNTF IGF1 OSX AND MIRNAS IN TOOTH DEVELOPMENT%WIKIPATHWAYS_20260510%WP3971%HOMO SAPIENS OSX and miRNAs in tooth development CTNNB1 NOTCH2 NOTCH3 DKK1 NOTCH1 DMP1 HNF1A RUNX2 DSPP ALPL KLF4 SP7 SOST BMP7 4P16 3 COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5365%HOMO SAPIENS 4p16 3 copy number variation NELFB NELFCD H3F3B GRB2 PLCG1 FGFR3 MAPK3 ERI1 MAPK1 FGF2 PIK3R1 FRS2 SOS1 POLN SLBP CLTCL1 NSD2 NELFA UBE2J2 FAM53A CKAP5 LETM1 NICOL1 TACC3 CBL NAT8L LIPID METABOLISM PATHWAY%WIKIPATHWAYS_20260510%WP3965%HOMO SAPIENS Lipid metabolism pathway PRKAA2 LIPE PRKACG PRKAG1 PRKAG2 ACACA PRKAA1 PRKAG3 PLIN1 ABHD5 ACSS2 PNPLA2 PRKAB2 HILPDA FASN PRKAB1 PDHA1 PRKAR1B AKT3 PRKAR1A ACLY MIRNA REGULATION OF DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260510%WP1530%HOMO SAPIENS miRNA regulation of DNA damage response CREB1 CHEK1 MRE11A NBN APAF1 BBC3 CASP8 CCNE2 RFC1 SFN RAD9A CDKN1A PRKDC CCNB3 CCNB2 CCNB1 CCND1 MYC FAS CYCS CDC2 CDK2 FANCD2 ATR TLK1 TNFRSF10B TP53AIP1 SMC1A ATRIP RAD17 RAD1 RB1 PML HUS1B BRCA1 PIDD1 MDM2 CCNG1 TLK2 CDK5 CDK6 CDK4 RRM2B DDB2 SESN1 GADD45B PMAIP1 GADD45A GADD45G BAX H2AX CASP9 RAD52 CCND3 CDKN1B CCNE1 CASP3 ATM CCND2 RAD50 CHEK2 RAD51 INTERACTIONS BETWEEN IMMUNE CELLS AND MICRORNAS IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260510%WP4559%HOMO SAPIENS Interactions between immune cells and microRNAs in tumor microenvironment CCL2 STAT3 TGFBR2 CTLA4 TLR4 TLR7 IL2RG PDCD1 IL2RB IL4 IL2RA TGFB1 NFKB2 TLR8 CD80 TRAF6 IRAK4 NFKB1 SOCS1 CCL5 VITAMIN D SENSITIVE CALCIUM SIGNALING IN DEPRESSION%WIKIPATHWAYS_20260510%WP4698%HOMO SAPIENS Vitamin D sensitive calcium signaling in depression TPH2 ITPR2 CACNA1C CYP27B1 ATP2B3 ATP2B2 ATP2B1 NR1i1 CHRM1 BCL2 SLC8A1 RXRA KDM6B KCNQ2 KCNQ3 KDM3A CYP27A1 NFE2L2 KDM1A GRIN2B HEL-75 KDM1B GRIN1 GCLC CALB1 ATP2B4 PVALB TPH1 APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20260510%WP384%HOMO SAPIENS Apoptosis modulation by HSP70 APAF1 MAPK10 CASP8 CASP6 TNFSF6 CASP2 FADD RIPK1 CASP9 MAP3K1 AIFM1 CASP3 TNFRSF1A FAS NFKB1 CYCS METABOLIC PATHWAYS OF FIBROBLASTS%WIKIPATHWAYS_20260510%WP5312%HOMO SAPIENS Metabolic pathways of fibroblasts PLOD1 ALDH18A1 ADAMTS2 GCK GLS PSAT1 PHGDH PSPH BMP1 FGFR4 P4HA1 PLCG1 LOXL2 P4HA2 LPAR1 FGFR1 GLUD1 UGDH HEL-S-133P P3H4 P3H3 ARHA P4HA3 CD36 THYROID HORMONES PRODUCTION AND PERIPHERAL DOWNSTREAM SIGNALING EFFECTS%WIKIPATHWAYS_20260510%WP4746%HOMO SAPIENS Thyroid hormones production and peripheral downstream signaling effects TTF2 AQP7 TTF1 NHSL1 DUOXA2 SECISBP2L ITPR2 DUOX2 DEHAL1 TG SLC26A4 SLCO1C1 MAPKAPK3 SLC16A10 SLC16A2 RPS6 TPO RPTOR RPS6KB1 MAPK14 AKT3 POMC MLST8 HRAS CTNNB1 TSC2 TSC1 RXRA AKT1S1 SOS1 MAFA PIK3CA WNT4 ADRB3 SRC ITGB3 FOXO1 FGF21 ATF2 ITGAV ADCY3 PAX8 ADCY8 THRA MTOR ACTL6B RHEB SHH MDM2 GRB2 PPARG FGFR1 PFKFB2 CREB3 MAPK1 RAF1 SLC5A5 SIRT6 PRDM16 TBC1D4 RPS6KA6 TSHB FRS2 ZNF516 NOTCH1 BAD PLIN1 MGLL TSHR GSK3B KDM3B MC4R UCP1 DIO1 NPY CASP9 AgRP PNPLA2 KDM1A NR1A2 NPPB MAP2K1 PPARGC1A TRH PROSTAGLANDIN AND LEUKOTRIENE METABOLISM IN SENESCENCE %WIKIPATHWAYS_20260510%WP5122%HOMO SAPIENS Prostaglandin and leukotriene metabolism in senescence GNAI1 MAPK11 PTGIS PRXL2B KRAS CDKN1A ALOX5AP PTGES ALOX12 IGFBP5 GNAS HRAS NRAS ALOX15 SIRT1 PTGER4 PTGS2 PTGS1 PTGER1 PTGER2 LTC4S PTGER3 ALOX15B ALOX5 RB1 ADCY3 SRF AND MIRS IN SMOOTH MUSCLE DIFFERENTIATION AND PROLIFERATION%WIKIPATHWAYS_20260510%WP1991%HOMO SAPIENS SRF and miRs in smooth muscle differentiation and proliferation MEF2D KLF4 CAMK2D MYOCD NKX2-5 CCND2 MEF2C MEF2B FAMILIAL HYPERLIPIDEMIA TYPE 2%WIKIPATHWAYS_20260510%WP5109%HOMO SAPIENS Familial hyperlipidemia type 2 EPHX2 APOB GHR LIPC LPL PCSK9 APOA4 PLTP APOA2 LDLR USF1 GPIHBP1 CAFFEINE AND THEOBROMINE METABOLISM%WIKIPATHWAYS_20260510%WP3633%HOMO SAPIENS Caffeine and theobromine metabolism CYP1A2 XDH CYP2A6 NAT2 BLOOD BASED NEUROINFLAMMATION MARKERS %WIKIPATHWAYS_20260510%WP5548%HOMO SAPIENS Blood based neuroinflammation markers PBR CCL2 BDNF TNF IL6 GRN CCL11 CCL23 ADM NEFL TREM2 OLR1 CRP TREM1 IL1B S100B GFAP CHI3L1 CX3CL1 CCL5 DBI TRANSCRIPTIONAL CASCADE REGULATING ADIPOGENESIS%WIKIPATHWAYS_20260510%WP4211%HOMO SAPIENS Transcriptional cascade regulating adipogenesis CEBPD CEBPB EGR2 GATA3 DDIT3 KLF15 CEBPG KLF2 KLF5 GATA2 PPARG CEBPA ALSTROM SYNDROME%WIKIPATHWAYS_20260510%WP5202%HOMO SAPIENS Alstrom syndrome IFT27 PTCH1 IFT25 SMO VCP BLOC1S4 VCPIP1 BLOC1S6 GPR161 BLOC1S1 CIMAP3 SNAPIN RFX2 DTNBP1 RFX3 RFX1 IFT81 TUBG1 RILPL1 MYO5B ALMS1 STX5A IFT74 ACTN4 TFDP2 CEP192 CEP19 IFT172 E2F4 RABL2B DNM3 LIDOCAINE METABOLISM%WIKIPATHWAYS_20260510%WP2646%HOMO SAPIENS Lidocaine metabolism CYP1A2 CYP3A4 FERROPTOSIS%WIKIPATHWAYS_20260510%WP4313%HOMO SAPIENS Ferroptosis SLC3A2 MAP1LC3C SLC7A11 HMOX1 AKR1C2 CYBB DKFZp762B153 MAP1LC3A TFRC ATG5 SAT2 POR CHMP6 CHMP5 TF DPP4 FTMT CP PCBP1 LPCAT3 FTL ACSL1 FACL4 IREB2 SLC40A1 ACSL3 BACH1 HEL-S-102 COQ2 CBS FTH1 SLC39A8 AKR1C1 CISD1 ACSL6 ACSL5 GPX4 ALOX15 STEAP3 SLC38A1 HEL-S-64p SLC39A14 HMGCR PHKG2 PRNP SLC11A2 GCLC AIFM2 VDAC3 CTH GCLM FDFT1 NOX4 KREBS CYCLE DISORDERS%WIKIPATHWAYS_20260510%WP4236%HOMO SAPIENS Krebs cycle disorders LDHB SUCLG2 PDHX PCK2 FH SUCLA2 DHTKD1 MPC1 HEL-S-133P SUCLG1 GPT VALPROIC ACID PATHWAY%WIKIPATHWAYS_20260510%WP3871%HOMO SAPIENS Valproic acid pathway HDAC1 HADHB EHHADH CYP2A6 CYP2B6 HSD17B10 IVD ACADSB CYP2C9 ABAT INTEGRATED BREAST CANCER PATHWAY%WIKIPATHWAYS_20260510%WP1984%HOMO SAPIENS Integrated breast cancer pathway CREB1 CHEK1 MRE11A EP300 BRCA2 CDC25B ANXA1 GRN DAG1 APOBEC3G BRAF BLM SMAD2 SMAD4 FOSL2 PLK1 HIPK2 FOSL1 CDK7 SP1 CDK2 BCL2 ATR CTNNB1 SMAD1 TFPI ERAL1 SMEK1 ZMYND8 NAB1 MAP3K7CL JUN ALKBH1 RPP38 RALGAPA1 PPP4R3B BMPR1A CCNB1IP1 HDAC1 LGALS13 BMPR2 RB1 NUP85 PLK3 XRCC3 FER MAP3K7IP1 MAP3K13 PIGR RASGEF1A DCAKD ITPKC USP15 WEE1 USP16 AURKA USP21 FILIP1 MAX TPR MSH6 SMARCA4 CDK4 CHUK RRAS BARD1 TRADD MAPK1 NFKB1 CDC42 CERK ZNF655 SIRT1 RAP1A FAU RASGRP3 IRS1 ZMIZ1 UBE2F PIAS1 RALA CASP8 FADD GSK3A GDI1 JAK1 PTEN STAT1 AHR PKIA CCND1 MYC TGFBR1 MYCBP2 TSC2 TSC1 SMAD6 BACH1 CSNK1D EGFR FOXO1 DHTKD1 PML MTOR MSH2 RHEB BRCA1 MDM2 KRAS NOXA1 ATF1 EDAR RHO ARAF RAC1 STK11 MYT1 PIK3R2 TGFBR2 SELENOK PAK1 BAK1 BAD GADD45A NF1 BAX VEGFA CASP9 HMGCR ATM CASP3 RAD50 CHEK2 RAD51 MITOCHONDRIAL COMPLEX III ASSEMBLY%WIKIPATHWAYS_20260510%WP4921%HOMO SAPIENS Mitochondrial complex III assembly UQCRB UQCC3 UQCC2 UQCR11 UQCR10 TTC19 CYB UQCRH UQCRQ LYRM7 UQCRC1 UQCRFS1 CYC1 UQCRC2 UQCC SOX GENES AND THEIR INFLUENCE ON NEUROGENESIS AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260510%WP5568%HOMO SAPIENS SOX genes and their influence on neurogenesis and neurodevelopmental disorders WWTR1 SOX4 YES1 SOX2 POU3F2 TEAD2 SRRT SOX11 SOX12 POU3F1 UTF1 FGF7A SOX15 ZSCAN10 H4C9 HIST1H4L INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20260510%WP453%HOMO SAPIENS Inflammatory response pathway ZAP70 LAMB2 LAMA5 IL2RG LAMB1 VTN IL5RA CD40LG THBS1 IL2 IFNG LCK IL2RB COL1A2 THBS3 CD40 IL4 TNFRSF1B COL1A1 COL3A1 IL2RA CD80 LAMC2 TNFRSF1A LAMC1 IL5 PROXIMAL TUBULE TRANSPORT%WIKIPATHWAYS_20260510%WP4917%HOMO SAPIENS Proximal tubule transport SLC2A2 SLC3A2 SLC9A3 SLC5A1 HEL-76 CA4 SLC22A2 ATP6V1C1 SLC34A3 SLC4A4 ATP6V1G1 SLC6A19 SLC34A1 SLC6A18 SLC16A10 SLC7A7 SLC36A2 SLC5A8 CLTRN SLC7A9 SLC3A1 SLC47A2 SLC5A2 ATP6V1A SLC6A20 SLC22A6 SLC47A1 FXYD2 SLC5A5 ATP6V0A4 ATP6V0E1 ATP6V0D2 ATP6V1D SLC22A11 ATP6V1E1 ATP6V0B ATP6V0C SLC22A7 ATP6V1B1 AQP1 ABCC2 ABCB1 ATP6V1F ATP1B1 ABCG2 SLC1A1 ATP1A1 MITOCHONDRIAL FATTY ACID SYNTHESIS PATHWAY%WIKIPATHWAYS_20260510%WP4317%HOMO SAPIENS Mitochondrial fatty acid synthesis pathway OXSM HTD2 MCAT MECR ACACA HSD17B12 OREXIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260510%WP5094%HOMO SAPIENS Orexin receptor pathway CREB1 PRKD1 LHB EIF4B PRKCZ IL9 GNRH1 MAPK9 MAPK8 IL10 MAPK3 DAGLA RPS6 RPS6KB1 CCK MAPK14 POMC GNAS STAR MAP2K2 TH ARRB2 HIF1A SMAD1 DKFZp781O1323 IL4 PDPK1 BMPR1A FOXO1 EIF4EBP1 GNAI1 GCG STAT3 MTOR GNA11 DYNLT1 RUNX2 IL1B MAPK7 MAPK1 CXCL2 CAMKK2 BMP7 LEP GH1 SLC2A4 TNF PIK3R2 PIK3R1 NPFFR1 IL6 FSHB BGLAP RPS6KA1 SGK1 NPVF HCRT PRKAA1 VHL OPRK1 CGA PTPN11 HCRTR2 CXCL8 HCRTR1 NPY CASP9 PRKCB PRKCE PRKCA NFE2L2 CASP3 GHRL SLC1A2 MAP2K1 DYNLT3 NOX4 G13 SIGNALING%WIKIPATHWAYS_20260510%WP524%HOMO SAPIENS G13 signaling MAPK10 WASL ARHGDIG ARHGDIB PKN1 HEL-S-80p TNK2 CIT PIK3CD RPS6KB1 ARHGEF1 ROCK1 RAC1 ROCK2 WAS ARHA SH3RF1 GNA13 CDC42 CALM1 PIK3R2 CFL2 LIMK1 PIP4K2A RTKN RHPN2 MYL1 MYBPH PFN1 IQGAP1 PIK3CA HEL-S-15 CYFIP1 AMYOTROPHIC LATERAL SCLEROSIS ALS %WIKIPATHWAYS_20260510%WP2447%HOMO SAPIENS Amyotrophic lateral sclerosis ALS APAF1 BCL2L1 SMIM40 RAB5A PPP3CC MAPK14 RAC1 PPP3CA MAP2K6 MAP2K2 BCL2 TNF HEL-S-2 HEL-S-44 NEF3 GPX1 BAD TOMM40 NEFL DERL1 BAX CASP9 CASP12 CASP3 MAP3K5 TNFRSF1A SLC1A2 NEFH CCS MAPK PATHWAY IN CONGENITAL THYROID CANCER%WIKIPATHWAYS_20260510%WP4928%HOMO SAPIENS MAPK pathway in congenital thyroid cancer MAP2K2 KSR1 GAREM2 KRAS SOS1 SOS2 JUN MAPK3 SHC1 ALK BRAF MYC RAF1 MAP2K1 FOS EGF EGFR SIGNALING%WIKIPATHWAYS_20260510%WP437%HOMO SAPIENS EGF EGFR signaling SYNJ1 CREB1 MAP2K5 PTPN5 MAPK9 MAPK8 PLCG1 TNK2 JUND ARF6 BRAF MAPK14 STXBP1 PLCE1 SP1 FOSB SH2D2A AP2A1 JUN IQGAP1 HEL-S-15 SH3GL2 PCNA CBLC MEF2C HGS MEF2D FOXO4 GRB10 VAV1 MAP3K1 ARHGEF1 MAPK1 RAF1 ROCK1 CDC42 CSK MAPK4 GJA1 RALBP1 PLSCR1 EPN1 USP6NL RAP1A NDUFA13 INPPL1 PRKCB PLD2 STAMBP PRKCA STAM2 HEL-S-34 EPS15L1 ASAP1 REPS2 PIK3C2B RALA RALB ERBB2 RPS6KA3 INPP5D GAB2 PRKCZ LIMK2 JAK1 STAT5B RAB5A PTEN VAV3 STAT1 RPS6KB1 RIN1 AP2S1 AP2M1 NEDD8 HRAS MAP2K2 CRKL NCK2 SOS1 NCK1 SOS2 PDPK1 SHC1 SRC ITCH CAV2 CRK EGFR FOXO1 CAMK2A CBL EIF4EBP1 ATXN2 EGF STAT3 MTOR KRAS GRB2 VAV2 MAP3K2 MAP4K1 ATF1 MAPK7 RPS6KA5 PTK2B SPRY2 RAC1 PXDN PIK3R2 PIK3R1 PTK6 PAK1 NEDD4 RPS6KA2 RPS6KA1 SH3GL3 COX2 PTPN11 RICTOR ERRFI1 PRKCI MAP2K1 FOS INTERFERON SIGNALING IN TUBERCULOSIS%WIKIPATHWAYS_20260510%WP4197%HOMO SAPIENS Interferon signaling in tuberculosis IRF9 IFNAR2 IFNG IFNAR1 STAT2 MX1 TAP1 JAK1 STAT1 IFIT1 IRF1 IFITM1 IFNGR2 IFI35 PSMB8 IFIT3 IFNGR1 SOCS1 OAS1 TYK2 PIAS1 CODEINE AND MORPHINE METABOLISM%WIKIPATHWAYS_20260510%WP1604%HOMO SAPIENS Codeine and morphine metabolism UGT2B7 UGT1A10 UGT1A8 ABCC3 ABCC2 UGT1A9 ABCB1 CYP3A4 CYP2C8 UGT1A3 SLCO1B1 UGT1A1 UGT2B4 DISRUPTION OF POSTSYNAPTIC SIGNALING BY CNV%WIKIPATHWAYS_20260510%WP4875%HOMO SAPIENS Disruption of postsynaptic signaling by CNV DLG2 SHANK1 NLGN1 ARC FMR1 CAMK2G MAPK3 NRXN1 NRXN3 MAPK1 NRXN2 STX1A RPH3A RYR2 YWHAG SYNGAP1 DLGAP1 HOMER1 CAMK2D GRIN2B GRIN1 CAMK2A TJP1 NLGN3 NLGN2 CYFIP1 DENGUE 2 INTERACTIONS WITH COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260510%WP3896%HOMO SAPIENS Dengue 2 interactions with complement and coagulation cascades C1R CFI C5AR1 C4B_2 C2 C6 PLAT C7 C9 CD55 HEL-S-62p APOA2 C1QC THBD VWF SERPINF2 F5 F8 CPB2 SERPINC1 TFPI LMAN1 CLTC F2R SERPIND1 PLAUR KLKB1 F7 PLG F3 HEL-S-78p KNG1 BDKRB1 F13B F2 PROS1 CLU C8G SERPINA1 C3AR1 F9 PROC CR2 F10 CR1 SERPING1 MASP2 C1QA MASP1 CD46 CFD C1QB C1S CFH KININ KALLIKREIN PATHWAY%WIKIPATHWAYS_20260510%WP5089%HOMO SAPIENS Kinin Kallikrein pathway SERPING1 CPN1 KLKB1 KNG1 BDKRB2 BDKRB1 INVOLVEMENT OF SECRETASE IN NEURODEGENERATIVE DISEASES%WIKIPATHWAYS_20260510%WP5372%HOMO SAPIENS Involvement of secretase in neurodegenerative diseases SRPK2 BDNF CEBPB SET STAT1 SNCA AKT3 APP BACE1 NTRK2 TARDBP POST COVID NEUROINFLAMMATION%WIKIPATHWAYS_20260510%WP5485%HOMO SAPIENS Post COVID neuroinflammation IFNG TNF ACE2 TLR4 HMGB1 IL6 TLR7 TLR3 CCL11 IL10 IL1A IL4 CXCL8 FURIN IL12A IL1B TLR8 GFAP MAPK1 IL2 TMPRSS2 IL18 IFNA2 GENES AND COMPLEXES INVOLVED IN THE DNA REPAIR PATHWAYS%WIKIPATHWAYS_20260510%WP4946%HOMO SAPIENS Genes and complexes involved in the DNA repair pathways POLD2 CHEK1 MRE11A NBN BRCA2 RAD54B PARP2 MGMT RBX1 POLE4 PRKDC TDG POLE3 FEN1 FAN1 CDK7 FANCD2 ATR BRIP1 FANCM FANCL FANCA USP1 FANCC MPG OGG1 PNKP XRCC5 UNG NTHL1 PALB2 POLL MUTYH MBD4 PCNA SMUG1 NEIL3 NEIL2 HMGB1 MSH3 NHEJ1 POLE RFC3 RFC4 MSH6 POLD3 WRN RPA1 FANCG POLE2 RPA3 APEX1 RAP1A REV1 FANCB FANCE FANCF REV3L POLI RAD51C CETN2 FAAP24 XPA PMS2 XPC CENPX GTF2H2C_2 POLM LIG1 APEX2 RFC1 CENPS RFC2 GTF2H2 GTF2H3 GTF2H5 CUL4A DDB1 ERCC1 ERCC2 ERCC5 MNAT1 CUL4B MSH2 BRCA1 POLK WDR48 DDB2 TERF2 H2AX RAD52 ATM CCNH PARP1 POLD4 RAD50 RAD51 GASTRIC CANCER NETWORK 2%WIKIPATHWAYS_20260510%WP2363%HOMO SAPIENS Gastric cancer network 2 TOP2A RFC3 RFC4 AHCTF1 DSCC1 S100A6 CHTF18 MTDH CHTF8 BRIX1 UBE2C ATAD2 CACYBP FAM91A1 RNF144B DGIC UBE2T COL9A1 SNURF MYC CD48 COL9A3 CEBPZ LBR CTNNB1 OTUD5 RAD17 EGFR LMNB2 ESTROGEN RECEPTOR PATHWAY%WIKIPATHWAYS_20260510%WP2881%HOMO SAPIENS Estrogen receptor pathway JUN CYP1A2 STAT3 GPAM PCK1 ACOX1 NR0B2 CYP1A1 PDK4 CYP1B1 NR1C1 SP1 FIBROTIC RESPONSE OF TRABECULAR MESHWORK CELLS TO TGFB3 AND ENPP2 IN AQUEOUS HUMOR%WIKIPATHWAYS_20260510%WP5545%HOMO SAPIENS Fibrotic response of trabecular meshwork cells to TGFB3 and ENPP2 in aqueous humor COL1A1 TGFB1 STAT3 RHO MAPK10 CTGF MAPK9 LPA ACTA2 MAPK8 ENPP2 ARTEMISININ INHIBITION OF UVEAL MELANOMA%WIKIPATHWAYS_20260510%WP5441%HOMO SAPIENS Artemisinin inhibition of uveal melanoma MTOR AKT3 INTERLEUKIN 1 IL 1 STRUCTURAL PATHWAY%WIKIPATHWAYS_20260510%WP2637%HOMO SAPIENS Interleukin 1 IL 1 structural pathway MAP2K3 MAPK10 NFKBIB IRF7 MAPK11 RELA MAPKAPK2 MAPK9 MAPK8 IL1R1 IL1A MAP3K8 TAB3 MAPK3 IKBKB NFKBIA RPS6KA5 MAP3K1 CHUK TRAF6 MAPK1 MAPK14 IRAK4 MYC MAP3K14 NFKB1 MAP2K6 MBP SAFB MAP2K2 TANK MYD88 MAP2K4 EIF4E MAP3K7 IRAK2 MAP3K7IP1 ATF2 MAP2K1 IRAK1 FOS ENTEROHEPATIC CIRCULATION OF BILE ACIDS%WIKIPATHWAYS_20260510%WP5396%HOMO SAPIENS Enterohepatic circulation of bile acids SLC51B ABCB11 SLCO1B1 ABCC3 FABP6 ABCC2 ABCB1 SLC10A2 SLC51A OVERLAP BETWEEN SIGNAL TRANSDUCTION PATHWAYS CONTRIBUTING TO LMNA LAMINOPATHIES%WIKIPATHWAYS_20260510%WP4879%HOMO SAPIENS Overlap between signal transduction pathways contributing to LMNA laminopathies CTSK HES5 TCF7L1 CSNK1A1L APC GDF8 PS1TP5BP1 PPARG CDKN1A RUNX2 HES1 CDK4 CREBBP TGFB1 WNT10B MYOD1 LMNA SMAD2 WNT7B ZMPSTE24 CEBPA TNFRSF11B CEBPD LEMD3 CTNNB1 CEBPB MAOA SPP1 NOTCH1 BMP2 GSK3B FNTA EMD TCF7L2 ICMT LEF1 HMGA2 HDAC1 AXIN1 DICER1 AGO2 TARBP2 RB1 JUNB CSNK1A1 KAT2B METASTATIC BRAIN TUMOR%WIKIPATHWAYS_20260510%WP2249%HOMO SAPIENS Metastatic brain tumor CDC42 PIK3R1 E2F3 MYC CDK6 BMP SIGNALING IN EYELID DEVELOPMENT%WIKIPATHWAYS_20260510%WP3927%HOMO SAPIENS BMP signaling in eyelid development INHBB PITX2 FGF10 SMAD1 SHH NOTCH1 MAPK9 DKK2 SFRP1 DKFZp781O1323 JUN BMP4 FGFR2 MAPK3 MAP3K1 FOXC2 FOXC1 EGFR SMAD4 TGFA CATABOLISM OF SKELETAL MUSCLE IN CACHEXIA%WIKIPATHWAYS_20260510%WP5474%HOMO SAPIENS Catabolism of skeletal muscle in cachexia EP300 STAT3 MTOR MAPK11 RELA TRIM63 FBXO32 GDF8 REL IL1R1 IL1A FOXO3A JAK1 IKBKB IL1B NFKBIA IGF1R CHUK RPTOR IKBKG SMAD2 SMAD4 NFKB1 MAP1LC3A MLST8 IL6R TNF CEBPB TWEAK RELB TNFRSF12A ACVR2A IL6 AKT1S1 NFKB2 TNFRSF1A IGF1 FOXA2 PATHWAY%WIKIPATHWAYS_20260510%WP5066%HOMO SAPIENS FOXA2 pathway PPARGC1B FOXA1 ABCC3 ABCC2 ACACA MTTP FOXA2 GSTM2 SLCO1B1 APOB FASN IRS1 FOXO1 SLC27A5 MLXIPL INS LEUCINE ISOLEUCINE AND VALINE METABOLISM%WIKIPATHWAYS_20260510%WP4686%HOMO SAPIENS Leucine isoleucine and valine metabolism ACAD8 ACSF3 DBT PCCA MLYCD HSD17B10 BCAT1 IVD BCAT2 ACADSB PCCB ECHS1 MCCC2 DLD MCCC1 ACAT1 FGFR4 P G388R SIGNALING%WIKIPATHWAYS_20260510%WP5428%HOMO SAPIENS FGFR4 p G388R signaling STAT3 FGFR4 IL10 WNT SIGNALING IN ADULT HIPPOCAMPAL NEUROGENESIS%WIKIPATHWAYS_20260510%WP5536%HOMO SAPIENS Wnt signaling in adult hippocampal neurogenesis WNT3 FZD3 CCND1 WNT3A LRP6 FZD1 NEUROG2 PROX1 NEUROD1 WNT7A LAMIN A PROCESSING PATHWAY%WIKIPATHWAYS_20260510%WP4299%HOMO SAPIENS Lamin A processing pathway ICMT LMNA ZMPSTE24 MULTIPLE EPIPHYSEAL DYSPLASIA AND PSEUDOACHONDROPLASIA GENES%WIKIPATHWAYS_20260510%WP4789%HOMO SAPIENS Multiple epiphyseal dysplasia and pseudoachondroplasia genes COMP COL9A1 COL9A3 MATN1 COL9A2 MATN3 NANOPARTICLE TRIGGERED REGULATED NECROSIS%WIKIPATHWAYS_20260510%WP2513%HOMO SAPIENS Nanoparticle triggered regulated necrosis TICAM1 TNF CASP8 TRADD TNFRSF1A FADD RIPK1 FTL MAPK8 PARP1 RIPK3 LNCRNA MEDIATED MECHANISMS OF THERAPEUTIC RESISTANCE%WIKIPATHWAYS_20260510%WP3672%HOMO SAPIENS lncRNA mediated mechanisms of therapeutic resistance HIF1A ABCB1 BCL2L1 CDKN1A SEBALEIC ACID FORMATION AND METABOLISM%WIKIPATHWAYS_20260510%WP5315%HOMO SAPIENS Sebaleic acid formation and metabolism FADS2 ALOX5 CYP4F3 FADS1 ACSL1 HEME BIOSYNTHESIS%WIKIPATHWAYS_20260510%WP561%HOMO SAPIENS Heme biosynthesis ALAS2 ALAS1 FECH HMBS UROD UROS CPOX ALTERED GLYCOSYLATION OF MUC1 IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260510%WP4480%HOMO SAPIENS Altered glycosylation of MUC1 in tumor microenvironment IKBKB TNF NFKBIA IL6 CHUK RELA IKBKG NFKB1 MUC1 BDNF SIGNALING IN NEURODEVELOPMENT%WIKIPATHWAYS_20260510%WP5541%HOMO SAPIENS BDNF signaling in neurodevelopment CREB1 DOCK7 TIAM1 MAP2K5 MAPKAPK2 HEL-S-47e MAPK8 PLCG1 MAPK3 ARHA ARHGAP35 BCL2 CTNNB1 CFL2 JUN PIK3CA HEL-S-15 WASL IQGAP3 IKBKB NFKBIA MAP3K1 CHUK TRADD TRAF6 MAPK1 IKBKG RAF1 ROCK1 ROCK2 HEL2 CDC42 LIMK1 PARD3 PRKCH PRKCB PRKCE PRKCA IRS1 SMPD1 APAF1 SH2B2 MAPK11 CASP8 BCL2L11 PRKCZ FADD PARD6B PARD6A FOXO3A PIK3CD RPS6KB1 RPS6KB2 MYC CYCS HRAS MAP2K2 YWHAQ HEL-S-1 SOS1 YWHAG MAP2K4 YWHAZ RTN4R PDPK1 SHC1 TCF7L2 LEF1 NPTX2 CRK SORT1 NGFR EIF4EBP1 NTRK2 STAT3 TCF7L1 MTOR KRAS EEF2 GRB2 TP73 RAPGEF1 MAPK7 LINGO1 KIDINS220 RAC1 BMP7 BDNF NRAS PAK1 FRS2 EEF2K BAD PTPN11 GSK3B EIF4E BAX CASP9 MAP3K5 PRKCI MAP2K1 PROSTAGLANDIN SIGNALING%WIKIPATHWAYS_20260510%WP5088%HOMO SAPIENS Prostaglandin signaling CSF1 IRF7 CCR2 IL1A PTGES IL12A TGFB1 IL1B CXCL9 AHR CXCL1 NFKB1 MMP9 CCL3 CCL2 IFNG TNF PYCARD IL6 NLRP3 PTGER4 AREG PTGER2 CXCL8 VEGFA IL17F IL17A KLRD1 IFNA1 DOWNREGULATION OF ACE2 BY SARS COV 2 SPIKE PROTEIN%WIKIPATHWAYS_20260510%WP4799%HOMO SAPIENS Downregulation of ACE2 by SARS CoV 2 spike protein ACE2 AGTR1 AGTR2 WNT SIGNALING AND PLURIPOTENCY%WIKIPATHWAYS_20260510%WP399%HOMO SAPIENS Wnt signaling and pluripotency PRKD1 EP300 PRKCZ FOXD3 PAFAH1B1 MAPK9 PTPA ZBTB33 CREBBP NR1C2 PPP2R2A PPP2R1B CCND1 PPP2R1A MYC NKD1 NKD2 FOSL1 ARHA PPP2R3B PPP2CA PPP2R3A CTNNB1 PPP2R2C PPP2R2B AXIN2 SOX2 CTBP1 LDLR NLK FRAT1 MAP2K4 DVL1 DVL2 JUN DVL3 WNT4 TCF7L2 POU5F1 LEF1 AXIN1 LRP5 CSNK1E FBXW2 CTBP2 PPM1J LRP6 WNT1 LRRK2 MAPK10 TCF7L1 WNT2B FZD10 APC MMP7 CTNND1 WNT5B WNT9B PPP2R5E PPP2R5C WNT16 FZD1 CD44 WNT3 WNT10B WNT10A FZD3 FZD2 FZD5 FZD4 WNT3A NFYA WNT7B FZD7 FZD9 WNT7A FZD8 GSK3B PRKCH PRKCB CCND3 MAP3K7 PRKCE PRKCA PRKCI CCND2 ESRRB PRKCQ 15Q13 3 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP4942%HOMO SAPIENS 15q13 3 copy number variation syndrome TRPM1 FANCD2 FYN MTMR10 OTUD7A GOLGA8R KLF13 CREBBP GOLGA8O GOLGA8Q ARHGAP11B GPR75 GRM6 GOLGA8H CHRFAM7A FAN1 CCL5 CHRNA7 KAT2B RETINOL METABOLISM%WIKIPATHWAYS_20260510%WP5188%HOMO SAPIENS Retinol metabolism BCO1 RPE65 RDH12 DHRS9 CYP2W1 AOX1 LRAT ADH1A CYP2A6 HEL-S-53e CYP1A1 DHRS4 CYP3A7 SDR16C5 AWAT2 PNPLA4 CIRCADIAN RHYTHM GENES%WIKIPATHWAYS_20260510%WP3594%HOMO SAPIENS Circadian rhythm genes CREB1 EP300 TPH2 CRH KCND2 PHLPP1 SKP1 PRKAA2 NONO SFTPC MAPK9 MAPK8 PRKDC JUND HNRNPD STAR DDC TH DBP MYBBP1A FBXW11 JUN SIK1 HDAC2 HDAC1 PPP1CC TCF2 SLC9A3 TOP2A SUV39H2 SUV39H1 CCAR2 EGR1 KMT2A NLGN1 SIN3A CRX PPARG CDK4 TYMS EZH2 ZFHX3 ROCK2 CHRM1 NPY2R ID3 NPAS2 RELB NPS ARNT2 HEL-S-2 DRD1 SIRT1 RPS27A DRD2 DRD3 NAMPT CHRNB2 UTS2R BTBD9 HCRTR2 HCRTR1 PER3 AgRP ADORA2A MTNR1B GHRH UBE3A UTS2 HOMER1 GHRL ADA TPH1 SFPQ NCOR1 PROK2 HEL-S-80p ID4 HDAC3 HS3ST2 AVP RORC PTEN NR2F6 RORA AHR ID2 AANAT HTR7 CPT1A FAS NR1H3 RAI1 NR1C1 TNFRSF11A DRD4 CRY1 NFIL3 PER2 SIX3 PROX1 NR1D1 MTTP PER1 CSNK1D CSNK1E NTRK1 NGFR CRY2 ADCY1 DYRK1A F7 NKX2-1 C1orf51 CRTC1 BTRC RORB PROK1 PML MAPK10 KCNH7 USP2 SOX14 CARTPT CLDN4 PSPC1 GNA11 TIMELESS NOS2 ATF5 SETX MAGEL2 THRAP3 BHLHB2 UBC OPN4 OPN3 MAGED1 FBXL3 KDM5A BHLHE41 HEBP1 RBM4 KLF10 PAX4 MC3R KCNMA1 NTRK3 PRF1 CIPC RBM4B ATOH7 PROKR1 NOCT ATF4 CAVIN3 LEP PASD1 CREM BMAL2 DDX5 IL6 METTL3 PRKAA1 GSK3B OGT MTNR1A KLF9 GFPT1 PPARGC1A NR1D2 EFFECTS OF MFN2 MUTATION%WIKIPATHWAYS_20260510%WP5443%HOMO SAPIENS Effects of MFN2 mutation MAP2 RAB3B TRAK1 ATAT1 RHOT1 DCTN1 KIF1B CASP8 RABAC1 DYNC2H1 DYNC1I1 DYNC1LI2 BAX RAB7A DYNC2I2 MFN2 SYPL1 CASP3 SNCA DYNC1H1 FAMILIAL HYPERLIPIDEMIA TYPE 1%WIKIPATHWAYS_20260510%WP5108%HOMO SAPIENS Familial hyperlipidemia type 1 APOA5 LIPC ANGPTL4 LPL APOA4 ANGPTL8 SEL1L ANGPTL3 PLTP LMF1 LDLR GPIHBP1 APOA2 APOC2 TGF BETA SIGNALING IN THYROID CELLS FOR EPITHELIAL MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260510%WP3859%HOMO SAPIENS TGF beta signaling in thyroid cells for epithelial mesenchymal transition CDH2 ID1 RUNX2 MAPK3 SNAI1 TNC HEL113 MAPK1 SMAD2 SMAD4 AKT3 CDH16 SNAI2 CDH6 AMP ACTIVATED PROTEIN KINASE SIGNALING%WIKIPATHWAYS_20260510%WP1403%HOMO SAPIENS AMP activated protein kinase signaling GYS1 PRKAA2 ACACA CDKN1A PLCB1 PIK3CD GYS2 CCNB1 RPTOR RPS6KB1 ACACB RPS6KB2 CPT1A TSC2 TSC1 PRKACG ADRA1B ADRA1A CCNA2 CRTC2 PIK3CA INS-IGF2 FASN EIF4EBP1 INSR MTOR ELAVL1 EEF2 PRKAB2 PRKAB1 CAMKK1 CAMKK2 LEP STK11 PIK3R3 SLC2A4 PIK3R2 PIK3R1 PPARGC1B LIPE ADIPOR2 PRKAG1 STRADA PRKAG2 EEF2K ADIPOR1 PRKAG3 CPT1C PRKAA1 SLC2A4RG CAB39 HMGCR NR2A1 LEPR STRADB FOCAL ADHESION PI3K AKT MTOR SIGNALING%WIKIPATHWAYS_20260510%WP3932%HOMO SAPIENS Focal adhesion PI3K Akt mTOR signaling CREB1 EIF4B PHLPP1 ANGPT4 CSF1 PRKAA2 IL2RG JAK3 ACACA MAPK3 PPP2R1B PPP2R1A IL2 PPP2R5B PPP2R5A PPP2R5D FGF2 XB PPP2R3A FGF7 PPP2R2C FGF8 PPP2R2B FGF9 F2R CRTC2 PIK3CA FGF20 TNC VEGFC FGF22 FGF21 IGF1 FGF16 SLC2A2 FGF14 FGF18 CSF3 FGF13 FGF12 FGF10 FGF8A FGF7B FGF7A PRLR FGF6B VEGFB SLC2A4 OSM FGF5C PRL GYS1 FOXA1 CDKN1A RAB11B FLT1 ITGA4 FLT4 PTEN PIK3CD ULK1 IGF1R RPTOR THBS2 AKT3 KDR MLST8 HRAS IL6R PDGFRA MAP2K2 ANGPT2 TSC2 TSC1 ANGPT1 HIF1A AKT1S1 IL2RB KIT SOS1 MET EPHA2 CSF1R IL2RA RAB8A EGFR ITGB3 FOXO1 ITGA6 ITGAV NGFR INSR MTOR RHEB MDM2 PPP2R5E NOS2 RAB10 KRAS GRB2 PPP2R5C FGFR4 COL4A2 FGFR3 FGFR2 FGFR1 HEL-S-125m THBS1 ITGA2 ITGB7 PIK3R2 PIK3R1 NRAS STRADA TCL1B SLC2A3 BAD TCL1A PELO HIF3A PHLPP2 COL11A2 CSHL1 GHB3 ITGB4 PFKFB1 CDKN1B PFKFB4 PPP2R3C PIK3IP1 PPP2R2D GYS2 GHR OSMR CDC37 PPP2CA VWF KPG_010 IRS4 LAMC1 ATF2 ITGB5 ITGAE ITGB8 CSF3R ITGA7 ITGA2B ELAVL1 RAB2A HSP90AB1 IKBKB ITGAM LPAR2 MAPK1 LPAR3 IKBKG LPAR4 RAF1 IFNA7 CHRM2 CHRM1 IFNAR2 ITGAX VEGFD IBSP IFNAR1 SPP1 COL4A1 COL4A4 IFNB1 COL4A6 NGF COL1A1 COL3A1 COL2A1 IL7R LAMC2 IRS1 PIK3R4 PIK3C2A INS PIK3C2B PIK3R5 LAMA1 LAMA4 LAMA3 LAMB3 LAMB2 LAMB1 RELN VTN GNG12 FOXO3A GNG11 GNG13 JAK1 RPS6 RPS6KB1 RPS6KB2 GNB2 GNB1 GNB4 GNB3 RAB14 EPO EPOR KITLG IL3RA ITGB6 GNGT1 COL1A2 PDPK1 EIF4EBP1 EGF GNG3 ITGB1 PDGFD LAMA5 GNG2 PDGFC HGF GNG5 PDGFA GNG4 EIF4E1B GNG7 GNG8 ATF6B CREB3L3 CREB3L4 CREB3L2 GNGT2 PFKFB2 COMP CREB3 TNR CREB5 ATF4 CHAD STK11 DDIT4 LIPE EFNA5 COL5A3 GNG10 EFNA4 COL5A2 EFNA1 PRKAA1 EFNA3 THBS4 THBS3 EFNA2 GSK3B CAB39 EIF4E LPAR1 VEGFA CASP9 MAP2K1 PPARGC1A PHOSPHOINOSITIDES METABOLISM%WIKIPATHWAYS_20260510%WP4971%HOMO SAPIENS Phosphoinositides metabolism INPP5D MTMR10 STM7 PLCH2 PLCD4 PLCG2 PLCG1 PLCB1 PTEN PIK3CD MTMR1 MTMR2 MTMR8 OCRL MTMR6 MTM1 PIP4P2 PLCH1 PLCB2 PIP4P1 PLCE1 SACM1L PIKFYVE PLCB4 PIP4K2A PLCD3 PIP4K2B PLCB3 PIK3CA PIP5K1A PIP5K1C MTMR3 MTMR12 PIK3R4 MTMR11 PIK3C2G MTMR9 PIK3C2A MTMR4 PIK3C2B SBF1 SBF2 GLYCOLYSIS IN SENESCENCE%WIKIPATHWAYS_20260510%WP5049%HOMO SAPIENS Glycolysis in senescence RB1 HEL-S-30 PRKAA1 HEL-S-133P ENO1 HEL-S-68p HEL-S-162eP MAMMARY GLAND DEVELOPMENT PREGNANCY AND LACTATION STAGE 3 OF 4%WIKIPATHWAYS_20260510%WP2817%HOMO SAPIENS Mammary gland development pregnancy and lactation stage 3 of 4 PTPN1 TFPI2 CLDN6 TTC9 PRL GAL HDGFL2 TPM3 BCL2L1 NR3C1 USF1 STAT5B EIF4G1 GJB2 CHUK NR3A2 CCND1 PGR MYC PRLR USF2 CEBPA YY1 TNFRSF11A CEBPB TNFSF11 NFIA ERBB4 EIF4E NRG1 CSN2 NFIB EGFR ELF5 ERBB3 ORAI1 ERBB2 DLGAP4 TNF RELATED WEAK INDUCER OF APOPTOSIS TWEAK SIGNALING%WIKIPATHWAYS_20260510%WP2036%HOMO SAPIENS TNF related weak inducer of apoptosis TWEAK signaling NFKBIB RELA CASP8 TRIM63 FADD MAPK9 MAPK8 MAPK3 TRAF1 IKBKB BIRC3 NFKBIA CHUK MAPK1 MAPK14 RAC1 RAF1 MAP3K14 NFKB1 TNF CTNNB1 TWEAK TRAF2 RELB TNFRSF12A TRAF5 TRAF3 BIRC2 RIPK1 GSK3B JUN NFKB2 MAP3K7 HDAC1 CASP3 METABOLISM OF ALPHA LINOLENIC ACID%WIKIPATHWAYS_20260510%WP4586%HOMO SAPIENS Metabolism of alpha linolenic acid FADS2 ALOX5 ALOX15 FADS1 ALOX12 PTGS2 GABA METABOLISM AKA GHB %WIKIPATHWAYS_20260510%WP4157%HOMO SAPIENS GABA metabolism aka GHB ALDH5A1 PON3 ADHFE1 GLS GLS2 GAD1 GAD2 ABAT HEL-S-166mP TRYPTOPHAN CATABOLISM LEADING TO NAD PRODUCTION%WIKIPATHWAYS_20260510%WP4210%HOMO SAPIENS Tryptophan catabolism leading to NAD production AADAT HAAO NMNAT1 IDO1 HEL-S-90n TDO2 NMNAT2 AFMID NMNAT3 NMRK2 NMRK1 NAPRT KYNU KMO NAMPT NADSYN1 FOLLICLE STIMULATING HORMONE FSH SIGNALING%WIKIPATHWAYS_20260510%WP2035%HOMO SAPIENS Follicle stimulating hormone FSH signaling CREB1 TSC2 MTOR FSHB RHEB SGK1 H3-4 FSHR CGA MAPK3 SRC PRKCA RPS6 RPS6KB1 RPS6KB2 MAPK14 FOXO1 MAPK1 RAF1 EIF4EBP1 APPL1 HYPOTHETICAL CRANIOFACIAL DEVELOPMENT PATHWAY%WIKIPATHWAYS_20260510%WP3655%HOMO SAPIENS Hypothetical craniofacial development pathway TFAP2A ARHGEF2 IRF6 TP63 ARHGAP29 ARHA HEART DEVELOPMENT%WIKIPATHWAYS_20260510%WP1591%HOMO SAPIENS Heart development NFATC2 FGF10 SHH NKX2-5 TBX20 BHLHB2 IRX4 TBX5 ISL1 TBX2 BMP4 FOXA2 SMYD1 HAND1 MAPK1 SMAD4 VEGFB PITX2 CTNNB1 BMP10 FGF8 SMAD1 FOXH1 NOTCH1 NFATC1 PTPN11 BMP2 HAND2 VEGFA NFATC3 BMPR1A FOXC2 FOXC1 VEGFC BMPR2 NFATC4 GATA4 ERBB3 HEY2 GATA6 TBX1 MEF2C HDAC6 INTERACTIONS IN THE CENTRAL NERVOUS SYSTEM%WIKIPATHWAYS_20260510%WP5426%HOMO SAPIENS HDAC6 interactions in the central nervous system EP300 DLG2 FUS DCTN1 HEL-S-67p PARK2 PRKCZ CSNK2A2 STUB1 GSK3A NR3C1 MAPK8 HEL-S-2a CSNK2B VCP HDAC9 MAPK3 HDAC11 IKBKAP FAT10 CYBB OPTN ITIH4 NEDD9 HEL113 KALRN ATXN3 SMAD2 HSF1 CCDC141 HSPA4 MAP1LC3A MIIP FOXP3 ARID3A GARS1 SP1 CNOT6 BCL2 TUBA1C CTNNB1 HDAC6 HEL-S-44 TUBB HIF1A MYD88 TUBA4A MIF MYH9 PXN TUBA2 POU5F1 EGFR HEL-S-102 HEL-S-32 KAT5 AURKA SNCAIP APC SHH ERG CFTR BIRC5 ADRBK1 SQSTM1 PTK2B MAPK1 SNCA RAC1 CD133 HEL-S-72p EP400 APOE BBIP1 BDNF RHOT1 SGK1 SIRT2 VHL GRIA2 GSK3B BAX HTT PRKCE FREP1 MAP3K5 TWIST1 DLG4 CDC20 MAP1B MAPRE1 ISG15 TARDBP PANCREATIC ADENOCARCINOMA PATHWAY%WIKIPATHWAYS_20260510%WP4263%HOMO SAPIENS Pancreatic adenocarcinoma pathway BRCA2 RELA BCL2L1 MAPK9 MAPK8 CDKN1A JAK1 MAPK3 TGFB1 PIK3CD STAT1 RPS6KB1 BRAF RPS6KB2 CCND1 SMAD2 SMAD4 AKT3 TGFBR1 dik MAP2K2 PIK3CA RB1 EGFR TGFA PAK6 PAK4 EGF STAT3 MAPK10 MTOR CDKN2A KRAS RAC3 CDK6 CDK4 IKBKB ARAF CHUK MAPK1 IKBKG RAC1 RAF1 POLK NFKB1 DDB2 CDC42 PIK3R3 PIK3R2 TGFBR2 PIK3R1 PAK1 E2F2 E2F3 BAK1 RALBP1 GADD45B BAD GADD45A GADD45G BAX VEGFA CASP9 PLD2 HEL-S-34 MAP2K1 RALA RALB ERBB2 RAD51 THYROXINE THYROID HORMONE PRODUCTION%WIKIPATHWAYS_20260510%WP1981%HOMO SAPIENS Thyroxine thyroid hormone production CREB1 MAP2K2 DUOX1 CLCN5 HEL-S-5 PRKAA2 DUOX2 TG PRKAA1 CGA TSHR RAP1A MAPK3 PRKCA TPO MAPK1 RAF1 MAP2K1 SLC5A5 NFKB1 TRH INTERACTIONS BETWEEN LOXL4 AND OXIDATIVE STRESS PATHWAY%WIKIPATHWAYS_20260510%WP3670%HOMO SAPIENS Interactions between LOXL4 and oxidative stress pathway IGFBP7 SUV39H1 FGF7 DDR1 EXOC6 HEL-S-7 SIRT1 PKD1 NRF1 BMP2 LOXL4 TGFB1 COL2A1 NFE2L2 NQO1 CDC37 ECSIT TRANSLATION INHIBITORS IN CHRONICALLY ACTIVATED PDGFRA CELLS%WIKIPATHWAYS_20260510%WP4566%HOMO SAPIENS Translation inhibitors in chronically activated PDGFRA cells EIF4B MAP2K3 MAPK10 MTOR MAP2K5 CSNK2A1 MAPK9 MAPK8 EIF4A2 MAPK3 EIF4G1 RPS6KA5 RPS6 RPTOR RPS6KB1 RPS6KB2 MAPK1 MAPK14 AKT3 MAP2K6 PIK3R3 MAP2K2 PIK3R2 PIK3R1 RPS6KA2 RPS6KA1 MAP2K4 EIF4E PIK3CA PIM1 PIM2 PRKCA RPS6KA4 MAP2K1 EIF4A1 EIF4EBP1 ESTRADIOL REGULATION IN PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260510%WP5235%HOMO SAPIENS Estradiol regulation in porto sinusoidal vascular disease CALM1 KCNN3 SP3 SP1 BUTYRATE INDUCED HISTONE ACETYLATION%WIKIPATHWAYS_20260510%WP2366%HOMO SAPIENS Butyrate induced histone acetylation ACLY PHOTODYNAMIC THERAPY INDUCED NF KB SURVIVAL SIGNALING%WIKIPATHWAYS_20260510%WP3617%HOMO SAPIENS Photodynamic therapy induced NF kB survival signaling CSF2 RELA REL IL1A BIRC5 IKBKB IL1B BIRC3 CHUK CD40LG TRAF6 CCND1 IL2 CXCL2 MMP2 NFKB1 MMP9 SELE BCL2L2 TNF VCAM1 RELB IL6 BIRC2 BCL2A1 PTGS2 CXCL8 VEGFA NFKB2 TNFRSF1A MMP3 EGLN2 CYTOSINE METHYLATION%WIKIPATHWAYS_20260510%WP3585%HOMO SAPIENS Cytosine methylation TET2 MBD3 TDG TET1 HEL-S-26 COMMON PATHWAYS UNDERLYING DRUG ADDICTION%WIKIPATHWAYS_20260510%WP2636%HOMO SAPIENS Common pathways underlying drug addiction CREB1 GNAI1 PS1TP5BP1 GRIA3 HEL-S-80p MAPK3 ARAF GJB1 CAMK4 MAPK1 RAF1 GNAS ACTG2 MAP2K2 CALM1 ACTG1 PRKACG DRD4 DRD1 PPP1R1A DRD2 GRIA2 RAP1A PRKCB PRKCA GRIN1 CAMK2A MAP2K1 GRIA4 ADCY1 PPP1CC ADCY8 EPITHELIAL TO MESENCHYMAL TRANSITION IN COLORECTAL CANCER%WIKIPATHWAYS_20260510%WP4239%HOMO SAPIENS Epithelial to mesenchymal transition in colorectal cancer CLDN6 MAP2K3 MAPK8 JAG2 DLL3 MAPK3 DLL4 TGFB1 FMNL2 JUP MAPK14 SMAD2 SMAD4 CLDN11 FOXM1 CLDN7 CTNNB1 TUSC3 HEL-S-79 CLDN2 CDKL2 CLDN3 CLDN9 PKP1 EIF5A2 CLDN22 WNT4 CLDN20 PIK3CA CLDN24 NRP2 CLDN23 CLDN10 CLDN15 CLDN14 CLDN19 STRAP CLDN18 CLDN17 CLDN16 CLDN1 TMPRSS4 RBBP4 GDF15 NUBPL CRB3 SUZ12 WNT2B FZD10 PKD1 EED WNT5B NOTCH3 WNT9B WNT9A WNT16 WNT8A WNT8B MEF2D EZH2 WNT3 WNT10B WNT10A FZD3 FZD2 FZD5 TRAF6 FZD4 MAPK1 WNT3A RAF1 WNT7B FZD7 FZD9 MAP2K6 MAPK13 WNT7A FZD8 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 TWIST2 FOXC2 TWIST1 ZEB2 SNAI2 MAPK12 MAPK11 VTN PIK3CD ID2 AKT3 PALS1 HRAS TGFBR1 PKP2 MAP2K2 FOXQ1 HIF1A PROX1 MMP15 SOS1 SOS2 MAP2K4 SHC1 LRP5 RBPJ LRP6 WNT1 TJP1 SPARC CDH2 CLDN4 KRAS FZD1 GRB2 ID1 COL4A2 SNAI1 MMP2 MMP9 PIK3R3 PIK3R2 PIK3R1 TGFBR2 PAK1 NOTCH2 NOTCH1 GSK3B CLDN5 LATS2 NR2C2 MAP2K1 CTDSP1 MITOCHONDRIAL COMPLEX II ASSEMBLY%WIKIPATHWAYS_20260510%WP4920%HOMO SAPIENS Mitochondrial complex II assembly SDHAF2 SDHB SDHAF3 SDHAF1 SDHAF4 SDHC SDHD SDHA EFFECT OF INTESTINAL MICROBIOME ON ANTICOAGULANT RESPONSE OF VITAMIN K ANTAGONISTS%WIKIPATHWAYS_20260510%WP5273%HOMO SAPIENS Effect of intestinal microbiome on anticoagulant response of vitamin K antagonists NPC1L1 NR1C2 SCARB1 NR1i2 CYP2C9 NR1C1 CD36 NR1i1 PROTEASOME DEGRADATION%WIKIPATHWAYS_20260510%WP183%HOMO SAPIENS Proteasome degradation PSMB6 PSMB2 PSMB3 PSMC1 HEL-S-276 UBE2D2 PSMD10 PSMD7 RPN2 RPN1 UBE2D1 HLA-B PSMB10 HLA-C PSMD5 UBE2B HLA-F UBC HLA-E HEL-S-283 PSMD12 PSME2 HEL-S-91n PSMD13 HIST1H2AB HEL-117 UBB HLA-G H2AZ1 PSMD11 UBE2D3 PSMC6 PSMC4 IFNG NEDD4 PSMD2 H2AX PSMA4 PSMD9 PSMD6 HLA-A PSMD4 PSMD3 PSMD1 PSMB8 UBA7 PSMA2 GIP AND GLP 1 FUNCTION BY TISSUE%WIKIPATHWAYS_20260510%WP5509%HOMO SAPIENS GIP and GLP 1 function by tissue GCG GIP MIR TARGETED GENES IN LYMPHOCYTES%WIKIPATHWAYS_20260510%WP2004%HOMO SAPIENS miR targeted genes in lymphocytes GPD2 GAS2L1 PKN2 POLE4 POLA2 MAP3K8 CBFB MAPK14 IGF2R FGF2 BCL2 CTNNB1 TNFRSF10B LPL AP2A1 ELOVL5 DNAJB1 FADS2 FADS1 HEL-S-26 SUCLG2 RAB27B KCNN4 NT5C3A PICALM HEL-S-30 MBNL1 GNA13 MRM1 CHAF1A RAB23 BACE1 NRP1 GYS1 BCL6 CDKN1A CCND1 PPP3CA PPP1R7 SH3BP4 SDCBP VCAM1 TUBA1A CXCL12 KIT MET CPNE8 NCL VEZT TMEM41B BACH1 PWP1 CSNK1D RAVER2 EGFR CIAO2A SEC62 HEL-S-303 CACNA2D1 FNDC3B FNDC3A MTRR CARHSP1 HEL-S-273 WDR82 FAR1 HACD3 ARL10 UBE2J1 COMMD9 GRPEL2 ATP6V1C1 MOV10 RHEB NCEH1 PDE3A STRN KRAS ANP32B PPP2R5C GFM1 MAGT1 PANX1 COL4A2 PTPRF COIL SERPINE2 SERP1 RDH10 C1QBP PLXND1 GNPNAT1 TUSC2 MAPK7 TMED7 ARID4B DCAF7 MRPS24 IGF2BP1 ELMOD2 TXN2 PNP TMT1A CHORDC1 AP3B1 PDLIM7 GOLGA7 CDK5RAP3 CSDE1 ARHG VPS39 PXDN ATP6V0E1 AMIGO2 TNLG5A ITGA2 IFRD1 RHOB NAPG NT5E HEL-S-66 PISD MPZL1 RNP24 SPRYD4 RAB34 TTC9C PPIF POM121 TPPP3 BDNF ATAT1 GPAM DDX5 NFIA RAB5C NEDD4 SLC1A4 SNX15 ADIPOR2 LAMTOR5 RTN4 LTN1 CORO1C E2F3 MRPL20 CPOX ABHD10 SAC3D1 POGLUT3 MPDU1 TCL1A KPNA3 ATP6V1F SNX6 SLC38A1 RARS1 CD164 PHC2 TPM1 STX7 BRPF3 UBE4A TBCA CDKAL1 MENT SFXN1 RAB30 CDKN1B SYPL1 SLC25A1 ARF4 PTMAP7 SLC12A2 TRAM1 GEMIN7 SRSF9 ABCG2 TMED10 ADPGK RAI14 TNFAIP2 ADAR LMNB2 TM6SF1 GFPT1 SNAP23 MRC2 SLC4A10 TMEM43 SPCS3 GNL3L TMED3 CHMP2A SRPRB TMEM109 CYP51A1 SH3BGRL3 DKFZp761E1322 POLD2 CALCOCO2 ACP2 NELFCD DOCK7 CTSC CYR61 SYNE2 SCYL1 SLC7A6 SYNE1 CDCP1 HEL-S-108 HSDL1 RFT1 FRG1 RCN2 PTRH1 RBMS1 UNC93B1 ANAPC1 SEC23A HEL-S-47e PTPA LUZP1 CYP1B1 SHOC2 NUFIP2 NXN CDIPT HSD17B12 AP3D1 ARCN1 ATG9A CAND1 WDR11 TDG TP53INP1 FMNL2 ZNF622 SLC25A24 GALNT7 NHERF2 GALNT1 SLC4A7 SLC25A32 PLK1 BET1 SPTLC1 ATG3 DHX15 CDKN1C PRPF40A SMC1A SMAD1 USP1 FXR2 FBXW11 RB1 MTHFD2 SRSF10 GSTM4 DNMT3B LAMC1 CLDN1 TPM3 ANXA2 CDKN2A PPP5C ARID1A EHMT1 CDK6 PRIM1 RRP8 TYMS DHX57 EZH2 LOC541469 IQGAP3 LAMTOR3 HOXA5 PGRMC1 OTULINL CEP72 POLR2C VTI1B HARS1 BRI3BP PEDS1-UBE2V1 FERMT2 HOXD8 RCOR1 MEOX2 VAMP3 MRPS33 TAF9B MTX1 TRMT1 TMEM59 CEBPB TRIP13 CAP1 LY6K GEMIN2 MSI2 ABHD11 PLAG1 NARS1 DOCK5 ARID2 NPRC TNFRSF10A TRPV6 UBE2S UTP15 MARS2 RBM19 SIGMAR1 ABCF2 SLC25A22 SNAP29 LAMC2 IRS1 ASH2L MCL1 MAPK12 HMOX1 SSNA1 SLC25A13 CUL4B AXL MYLIP ATP2A2 RQCD1 YWHAQ P4HA2 PPIB MYO1E HMGA1 PSAT1 PPP3R1 AKAP8 TGFBR2 PURA NOTCH2 NOTCH1 TERT NF2 EIF4E AURKB PRKCI PTBP1 MYB UHRF1 TRANSCRIPTION FACTORS REGULATE MIRNAS RELATED TO CARDIAC HYPERTROPHY%WIKIPATHWAYS_20260510%WP1559%HOMO SAPIENS Transcription factors regulate miRNAs related to cardiac hypertrophy PPP3R1 TGFB1 STAT3 RASGRF1 MYEF2 NFKB1 S1P RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20260510%WP26%HOMO SAPIENS S1P receptor signal transduction GNAI1 SPHK1 MAPK12 MAPK6 S1PR5 MAPK4 SMPD2 PLCB1 MAPK3 PLCB3 MAPK7 S1PR1 SPHK2 S1PR3 MAPK1 S1PR2 AKT3 PLCB2 GNAI3 PIK3C2B CELL DIFFERENTIATION EXPANDED INDEX%WIKIPATHWAYS_20260510%WP2023%HOMO SAPIENS Cell differentiation expanded index LEFTY1 TLX3 STAT3 TLX2 TLX1 SOX2 RUNX2 MEF2D LEFTY2 KLF4 EZH2 MYOD1 PAX7 ID2 MEF2C HDAC5 MEF2B IL17 SIGNALING%WIKIPATHWAYS_20260510%WP2112%HOMO SAPIENS IL17 signaling STAT3 NFKBIB RELA MAPK3 JAK1 IKBKB TRAF6 TRAF3IP2 MAPK1 IKBKG MAP3K14 NFKB1 SP1 CEBPD IL17B CEBPB IL25 TRAF3 IL17RC GSK3B PIK3CA IL17F IL17D MAP3K7 IL17RB IL17C IL17A IL17RA MIR 517 RELATIONSHIP WITH ARCN1 AND USP1%WIKIPATHWAYS_20260510%WP3596%HOMO SAPIENS miR 517 relationship with ARCN1 and USP1 ARCN1 ID2 USP1 ID1 CDKN1A EICOSANOID SYNTHESIS%WIKIPATHWAYS_20260510%WP167%HOMO SAPIENS Eicosanoid synthesis PLA2G4B ALOX15 PTGIS PRXL2B PTGS2 PTGS1 ALOX5AP PTGES LTC4S PLA2G5 ALOX15B ALOX5 PLA2G6 ALOX12 PHOSPHODIESTERASES IN NEURONAL FUNCTION%WIKIPATHWAYS_20260510%WP4222%HOMO SAPIENS Phosphodiesterases in neuronal function CREB1 ADCY6 PDE3A GUCY1A2 PDE6D PDE6A PDE6G PDE4B PDE4A PDE8A PDE4D GUCY1B1 PDE1C PDE1B CHRNA7 PDE1A PDE5A PPP1R1B DRD1 DRD2 PRKG1 PDE7B PDE7A HEL-S-7a ADORA2A PDE3B PDE11A GRIN2B PDE6C GRIN1 PDE6H CAMK2A PDE2A ADCY9 PDE10A PDE12 ADCY3 PDE9A ADCY1 ADCY8 NAD METABOLISM%WIKIPATHWAYS_20260510%WP3644%HOMO SAPIENS NAD metabolism NMNAT1 SIRT5 NMNAT2 NMNAT3 SIRT1 SIRT2 SIRT3 NAMPT NADK PARP1 SIRT7 NRK SIRT6 NT5E SIRT4 GENETIC CAUSES OF PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260510%WP5269%HOMO SAPIENS Genetic causes of porto sinusoidal vascular disease DOCK6 CYBC1 COX4I2 CXXC5 CHCHD2 C4orf54 BEND6 GTF2I EFL1 SHCBP1 ARHGAP31 NCF1 IBTK NCF2 EIF6 SBDS NCF4 MAPK3 DLL4 CYBB CYBA MAPK1 BTK RAC1 NFKB1 SP1 CDC42 KCNN3 NOTCH1 TLR8 NOX3 DGUOK RBPJ TLR9 4 HYDROXYTAMOXIFEN DEXAMETHASONE AND RETINOIC ACIDS REGULATION OF P27 EXPRESSION%WIKIPATHWAYS_20260510%WP3879%HOMO SAPIENS 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression MAP2K2 PIK3R3 MAP2K3 PIK3R2 TSC2 PIK3R1 TSC1 MTOR MAP3K11 PRKAA1 HEL164 EIF4E MAPK3 PIK3CA PIK3CD MAPK1 MAP3K5 RAF1 MAP2K1 MAP2K6 EIF4EBP1 AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20260510%WP699%HOMO SAPIENS Aflatoxin B1 metabolism CYP1A2 GSTM1 CYP2A13 EPHX1 CYP3A4 HEL-S-166mP LEPTIN INSULIN SIGNALING OVERLAP%WIKIPATHWAYS_20260510%WP3935%HOMO SAPIENS Leptin insulin signaling overlap INSR PIK3R3 DGKZ STAT3 SOCS2 SOCS3 PDPK1 IRS4 IRS1 INS SOCS1 LEPR LEP SARS COV 2 AND ACE2 RECEPTOR MOLECULAR MECHANISMS%WIKIPATHWAYS_20260510%WP4883%HOMO SAPIENS SARS CoV 2 and ACE2 receptor molecular mechanisms ACE2 AGTR1 TMPRSS2 REN MGRA ENDODERM DIFFERENTIATION%WIKIPATHWAYS_20260510%WP2853%HOMO SAPIENS Endoderm differentiation NR1B3 MAP2K3 ACACA ZFHX4 CAND1 TGFB1 PAX3 DUSP2 SMAD2 SMAD4 TOX3 CTNNB1 TCF4 TET1 DKK1 SFRP1 SIAH2 BCORL1 BMPR1A HOXC11 CTBP2 DNMT3B LAMC1 GATA4 DUSP5 LHX1 MAD2L2 TCF2 PTHLH ELAVL1 WNT8A EZH2 WNT3 TOX AEBP2 MIXL1 APP SLC2A12 PABPC1 PIAS1 FOXA1 NODAL SOX17 CER1 NR3C1 SOX21 CEP250 SOX7 WDHD1 SFMBT1 CDYL VAV3 EMSY STAT1 RFX7 PBX3 RAB38 ATP8B2 CUL4B WDFY2 CTR9 PRDM14 RTF1 MBTD1 PLCH1 EPB41L5 LRPPRC CEBPZ UBR5 BPTF FOXN3 GDF3 TRERF1 OTX2 SP4 NABP2 PAF1 TAF4B TRIM71 ONECUT1 SOX2 PHF6 CDC73 NOG FOXH1 HHEX ZIC3 TBX21 NLK TRIM5 DUSP4 PARP8 EXT1 Pax9 AHDC1 BTAF1 TCEAL2 POU5F1 LEO1 LEF1 KDM4A ZNF462 ELP4 ZIC5 FOXO1 TNRC6C TAF5 HPRT1 NKX2-1 CRTC1 TCF7L1 APC PBX1 JARID2 FOXA2 C1QBP RGS10 WWC1 BMP7 HOXA1 SESN1 NOTCH1 GATA6 IL19 SIGNALING%WIKIPATHWAYS_20260510%WP5422%HOMO SAPIENS IL19 signaling STAT3 TNF CCL11 MAPK8 IL4 COL1A1 MAPK3 JAK1 TGFB1 STAT1 CCNB1 MAPK14 TNFRSF1A MAPK1 CXCR4 IL19 RAC1 IL20RA MUC5AC IL20RB NFKB1 ACTA2 SOCS1 SOCS5 ETHANOL EFFECTS ON HISTONE MODIFICATIONS%WIKIPATHWAYS_20260510%WP3996%HOMO SAPIENS Ethanol effects on histone modifications MTR SLC19A1 HDAC7 HDAC3 TYMS HDAC9 ACSS2 ADH1C HEL-S-117 ADH1A HAT1 ALDH2 HEL-S-53e CYP2E1 DHFR HDAC5 HDAC8 HDAC6 ALDH1A2 MAT1A HDAC2 HDAC1 HDAC10 ATF2 ALDH1A3 KAT2B TYROSINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260510%WP4506%HOMO SAPIENS Tyrosine metabolism and related disorders GSTZ1 HPD GLP 1 IN PANCREATIC ISLET CELLS%WIKIPATHWAYS_20260510%WP5447%HOMO SAPIENS GLP 1 in pancreatic islet cells SLC2A2 GCG IL6 INS GLP1R IL6R CLASSICAL PATHWAY OF STEROIDOGENESIS WITH GLUCOCORTICOID AND MINERALOCORTICOID METABOLISM%WIKIPATHWAYS_20260510%WP4523%HOMO SAPIENS Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism HSD11B1 HSD11B2 POR CYP21A2 CYP11A1 CYP17A1 HSD17B3 SRD5A2 HSD3B2 HSD3B1 CYP11B2 STAR H6PD TELOMERE END PACKAGING AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260510%WP5567%HOMO SAPIENS Telomere end packaging and neurodevelopmental disorders H2AB1 ACD TINF2 TERF1 POT1 H2AJ H2AC19 H2AC14 H2BC26 H3-4 H2BC12L H2BC21 HIST1H2AB H2AC6 H2BC17 H2BC12 H2BC13 H2AZ1 H2BC14 H4C9 H2BC15 H2BC11 HIST1H4L HIST1H2BE TPP1 H2BC9 TERF2 H2BC8 H2BC3 H2BC1 H2AC20 TERF2IP H2AX H2AZ2 CARDIAC HYPERTROPHIC RESPONSE%WIKIPATHWAYS_20260510%WP2795%HOMO SAPIENS Cardiac hypertrophic response PRKD1 MAP2K3 MAP2K5 CDK9 MAPK8 HDAC9 MAPK3 TGFB1 MAPK14 PPP3CA FGF2 TGFBR1 HDAC5 CDK7 MAP2K2 CALM1 MAP2K4 PDPK1 NRG1 CAMK2D IGF1 IKBKE NFATC2 EGF GUCA1A MTOR PLA2G2A MAP4K1 HDAC7 FGFR2 IKBKB MAPK7 MAP3K1 CHUK MAPK1 IKBKG RAC1 RAF1 MAP3K14 NFKB1 MAP2K6 TNF PRKG1 GSK3B MAP3K7 PRKCA TNFRSF1A NPPA MAP2K1 HSPB3 IN CHARCOT MARIE TOOTH DISEASE%WIKIPATHWAYS_20260510%WP5524%HOMO SAPIENS HSPB3 in Charcot Marie Tooth disease DMPK HP1BP3 HSPB3 NOTCH3 MYOG HSPB2-C11orf52 tmp_locus_29 MYOD1 H2AZ1 HEL25 ACTA1 LMNA MEF2C LBR AMINO ACID METABOLISM PATHWAY EXCERPT HISTIDINE CATABOLISM EXTENSION%WIKIPATHWAYS_20260510%WP4661%HOMO SAPIENS Amino acid metabolism pathway excerpt histidine catabolism extension GLUD1 FTCD HAL UROC1 GPT2 RUBINSTEIN TAYBI SYNDROME 1%WIKIPATHWAYS_20260510%WP5367%HOMO SAPIENS Rubinstein Taybi syndrome 1 CREB1 CREBBP NPAS2 PCNA MAFG FOXO1 SMAD4 FBL HEL23 IRF2 DDX21 MET IN TYPE 1 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260510%WP4205%HOMO SAPIENS MET in type 1 papillary renal cell carcinoma JAK3 MAPK8 CDKN1A PLCG1 MAPK3 PIK3CD BRAF AKT3 KDR HRAS MAP2K2 CRKL SOS1 RPL11 SOS2 INSL3 MET JUN PIK3CA SRC ALK CRK ELOA CBL PAK6 PAK4 STAT3 HGF KRAS STRN GRB2 C8orf34 RAPGEF1 ARAF MAPK1 RAC1 RAF1 CDC42 PIK3R3 PIK3R2 PIK3R1 NRAS PAK1 BAD PTPN11 RAP1A VEGFA MAP2K1 PRCC EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP581%HOMO SAPIENS EPO receptor signaling EPOR MAP2K2 STAT3 PTPRC GRB2 SOS1 PTPRU CISH MAPK3 STAT5B SHC1 SRC STAT1 IRS1 MAPK1 RAF1 MAP2K1 SOCS1 EPO FLUOROPYRIMIDINE ACTIVITY%WIKIPATHWAYS_20260510%WP1601%HOMO SAPIENS Fluoropyrimidine activity DPYS UCK2 UCK1 TYMP TYMS FPGS UPP2 TDG GGH DPYD ERCC2 UMPS CYP2A6 RRM1 RRM2 DHFR SLC22A7 CES2 CES1 ABCC3 ABCC5 CDA TK1 SMUG1 SLC29A1 ABCG2 XRCC3 PDGF PATHWAY%WIKIPATHWAYS_20260510%WP2526%HOMO SAPIENS PDGF pathway STAT3 WASL TIAM1 PDGFA GRB2 MAPK8 VAV2 PLCG1 MAPK3 JAK1 NFKBIA MAP3K1 STAT1 VAV1 CHUK MAPK1 RAC1 RAF1 NFKB1 ARHA HRAS CDC42 PIK3R1 PAK1 COX2 PTPN11 SOS1 MAP2K4 JUN SHC1 SRC MAP2K1 FOS ATOPIC DERMATITIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260510%WP5538%HOMO SAPIENS Atopic dermatitis mechanism and therapies STAT3 IL25 IL2RG JAK3 IL13RA1 IL13 IL4 IL1RL1 FCER1G MS4A2 CRLF2 IL33 OSMR TSLP IL5 TYK2 FCER1A SOMATIC SEX DETERMINATION%WIKIPATHWAYS_20260510%WP4814%HOMO SAPIENS Somatic sex determination WT1 CTNNB1 FOXL2 NR5A1 FGF9 DMRT1 DHH SOX9 SOX8 RSPO1 WNT4 GATA4 SRY AMH B CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP23%HOMO SAPIENS B cell receptor signaling CREB1 INPP5D GAB2 RELA BCL6 GTF2I TEC GSK3A MAPK9 MAPK8 PLCG2 PLCG1 LYN CARD11 SYK BCL10 BRAF BTK MAPK14 MYC HRAS MAP2K2 CD79A LCK PTPRC CD19 CRKL SOS1 NCK1 PDPK1 JUN SHC1 HCLS1 NFATC3 PIP5K1A PIP5K1C CRK FOXO1 CAMK2A ATF2 CD81 CBL NFATC2 FYN PTPN6 STM7 REL CD79B MAX GRB2 VAV2 MAP4K1 RAPGEF1 IKBKB NFKBIA VAV1 CHUK LAT2 DAPP1 MAPK1 PTPN18 IKBKG TIEG2 RAC1 RAF1 PIK3AP1 BLK NFKB1 MAP2K6 CDC42 PIK3R2 PIK3R1 MAPK4 CR2 RPS6KA1 PTPN11 GSK3B PRKCB MAP3K7 RASGRP3 BLNK MAP2K1 CD22 METABOLIC REPROGRAMMING IN PANCREATIC CANCER%WIKIPATHWAYS_20260510%WP5220%HOMO SAPIENS Metabolic reprogramming in pancreatic cancer DLAT GLS2 SLC7A5 KRAS CARM1 RPIA GNPNAT1 GLUD1 PGM3 DLD HEL-S-30 HEL-S-133P RPE GPT SLC16A4 GOT2 ME1 SOAT1 PDHX LDLR BCAT2 PFKL HMGCR FASN PDHA1 HEL-S-32 GFPT1 CS HK2 ACLY IL7 SIGNALING%WIKIPATHWAYS_20260510%WP205%HOMO SAPIENS IL7 signaling MAP2K2 STAT3 PIK3R2 PIK3R1 IL7 FYN IL2RG JAK3 BAD GSK3B MAPK3 JAK1 STAT5B STAT1 PTK2B IL7R MAPK1 MAP2K1 LIPID PARTICLES COMPOSITION%WIKIPATHWAYS_20260510%WP3601%HOMO SAPIENS Lipid particles composition APOE APOB LPL APOA2 LDLR APOC3 APOC2 1Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP4905%HOMO SAPIENS 1q21 1 copy number variation syndrome PRKAA2 BCL9 FMO5 KIRREL1 PRKAB2 PRKAB1 F11R ACP6 AFDN AMELX NBPF12 CHD1L PYGO2 CTNNB1 PRKAG1 GJA1 PYGO1 TJP3 PRKAG2 GJA3 PRKAA1 PRKAG3 GJA5 GJA8 TJP1 MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20260510%WP129%HOMO SAPIENS Matrix metalloproteinases MMP7 TIMP1 MMP14 MMP2 MMP9 TNF TCF20 MMP21 MMP20 MMP26 hEMMPRIN MMP25 TIMP4 MMP24 MMP23B MMP27 MMP10 MMP11 MMP16 TIMP3 MMP15 MMP17 MMP19 MMP28 MMP3 MMP12 LIVER X RECEPTOR PATHWAY%WIKIPATHWAYS_20260510%WP2874%HOMO SAPIENS Liver X receptor pathway CYP7A1 ABCG8 ABCG5 RXRA SCD FASN CYP2B6 CYP3A4 NR1H3 SPLICING FACTOR NOVA REGULATED SYNAPTIC PROTEINS%WIKIPATHWAYS_20260510%WP4148%HOMO SAPIENS Splicing factor NOVA regulated synaptic proteins CADM1 CDH2 PRKCZ MAPK9 AGRN CAMK2G CSN3 KCNJ6 GRIK2 ATP2B1 GABBR2 KCNMA1 GABRG2 GPHN MAPK4 PLCB4 EFNA5 CHL1 EPB41L3 KCNQ2 NCDN RAP1GAP NEO1 NTNG1 TERF2IP CADM3 SNW1 DAB1 STX2 MAP4 CAV2 GRIN2B CLASP1 GRIN1 CASK INSULIN SIGNALING%WIKIPATHWAYS_20260510%WP481%HOMO SAPIENS Insulin signaling ARF1 MAP2K3 MAP2K5 PRKAA2 MAPK9 MAPK8 MAP3K8 MAPK3 GYS2 ARF6 GYG1 MAPK14 SNAP25 STXBP1 SOCS1 INPP4A VAMP2 JUN PIK3CA IRS4 HEL-S-61 CBLC RPS6KA4 MAP3K13 MAP3K12 FLOT1 FLOT2 PTPN1 HEL-S-42 EGR1 MAP3K11 GRB10 IKBKB MAP3K1 MAPK1 RAF1 RAB4A MAP3K14 TRIB3 MAP2K6 MAPK13 PFKM TBC1D4 SLC2A4 MAPK6 CAP1 MAPK4 SGK1 KIF3A PRKCH INPPL1 PRKCB MAP3K7 PRKCA MYO1C IRS1 PIK3R4 PIK3C2G PIK3C2A XBP1 PRKCQ RPS6KA3 SH2B2 MAPK12 GYS1 MAPK11 PRKCZ STX4A GSK3A FOXO3A PTEN PIK3CD IGF1R RPS6KB1 RPS6KB2 HRAS MAP2K2 TSC2 TSC1 SOCS3 SOS1 SOS2 MAP2K4 PDPK1 SHC1 CRK FOXO1 SHC3 CBL EIF4EBP1 INSR MAPK10 MTOR RHEB GRB2 MAP3K2 MAP4K1 PTPRF MAP4K2 MINK1 RAPGEF1 MAPK7 RPS6KA5 MAP4K3 RAC1 SHC2 PIK3R3 MAP3K6 PIK3R2 PIK3R1 MAP3K10 LIPE RPS6KA6 RPS6KA2 RPS6KA1 PRKAA1 ENPP1 GRB14 PTPN11 STXBP3 STXBP4 GSK3B RRAD EIF4E PPP1R3A PFKL EHD1 EHD2 HEL-S-31 SGK2 SNX26 MAP3K5 PRKCI MAP2K1 SNAP23 FOS VITAMIN D RECEPTOR PATHWAY%WIKIPATHWAYS_20260510%WP2877%HOMO SAPIENS Vitamin D receptor pathway NINJ1 S100A4 COL13A1 EPHB4 KLK6 CRACR2A CRACR2B DND1 KRTAP4-1 SLC37A2 PRDM1 KRTAP12-2 KRTAP8-1 PNOC CLPTM1L S100A6 ALPG ZNF257 CD200 ORM1 IL12A ORM2 TGFB1 CASP14 DUSP10 ADGRE5 IGFBP1 CASP5 DACT2 KRTAP5-1 CA9 ABCD1 CAMP IGFBP5 KRTAP5-4 KRT34 CEACAM1 KRT38 SATB1 HEL57 CDK2 SEMA3B THBD ASAP2 CST1 CLMN IL25 CREG2 LRRC25 S100G KRTAP10-2 TNFAIP3 KRTAP10-4 CLDN2 KRTAP10-7 KRTAP10-9 SFRP1 KRT13 BMP6 MYO9B DEFB132 KRT16 CD9 CD14 FGF23 HLA-DRB1 CDKN2D CDKN2B CDKN2C S100A9 PTHLH KL CDKN2A PTH CYP2B6 KNG1 CYP27B1 BDKRB1 CYP24A1 KLF4 ITGAM CYP2S1 SLC2A4 SLC8A1 BGLAP SULT1C2 SPP1 CYP3A4 TRPV6 STEAP4 CYP2C9 CD40 COLEC11 ALPI PRKCQ BCL6 ADRB2 ID4 CDKN1A MED9 TREM1 NR1C2 CCND1 SALL4 MYC DEFB4B CLEC16A TNFRSF11B CYP7A1 TNFSF11 IRF4 RXRA HIF1A ADRA1B ABCB1 HLA-DQA2 HLA-DQA1 LRP5 ALOX5 FOXO1 DNER CST6 IRF8 LGALS9 NFATC2 CBS CTLA4 CDX2 TRPV5 S100A2 HNF1A ID1 MXD1 IL1RL1 HSD17B2 ATP2B1 S100A8 CYP1A1 SPRR1B SOSTDC1 CEBPA NR1i1 MX2 TRAK1 EFNA5 PTGER4 TNLG2B GADD45A ADAMTS5 TIMP3 TPM1 G0S2 CDKAL1 BTLA CDKN1B CCNE1 LPGAT1 CCNC JUNB HILPDA GXYLT2 STS SULT2A1 KRT71 SLC34A2 LCE1F LCE1D LCE2B CDC34 8P23 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP5346%HOMO SAPIENS 8p23 1 copy number variation syndrome TLR4 S100A10 NUMA1 TBX5 SOX7 MAPK3 ERI1 MTMR8 MTMR6 CTNNB1 NKX6-1 MCRS1 PDX1 BMP1 PINX1 HEPACAM2 CLDN23 SLC35G5 TNKS PRSS55 AXIN1 PPP1R3B CSTA MSRA PRSS51 NEIL2 DEFB136 C8orf74 DEFB135 DEFB134 CGAS GATA4 RP1L1 MFHAS1 FAM167A XKR6 FCGR2B TERF1 FCGR2A HSPD1 MAPK1 RAF1 BLK SLC2A4 HEL-S-130P TERT SLBP SGPL1 MTMR9 FDFT1 IRINOTECAN PATHWAY%WIKIPATHWAYS_20260510%WP229%HOMO SAPIENS Irinotecan pathway BCHE CES2 UGT1A10 CES1 SLCO1B1 ABCG2 ABCC2 UGT1A1 UGT1A9 CYP3A4 ABCC1 COMPLEMENT SYSTEM%WIKIPATHWAYS_20260510%WP2806%HOMO SAPIENS Complement system C5AR2 CFI C5AR1 LAMB1 CFP C2 VTN SFTPA2 ADM C6 C7 CRP C9 CD59 PTX3 SFTPA1 CD55 HEL-S-62p FCGR3A CLEC4M CD19 ICAM2 ARRB2 SELL DCN PLAUR RPS19 KLKB1 F13A1 SELP ITGB3 LAMC1 GNAI3 FGA CSNK1A1 VSIG4 HEL-S-99n ITGA2B CD93 PLG HEL-S-92n FCER2 FKBP2 HEL-S-78p LAMA5 FPR1 ALB ELANE F11 CFHR2 CFHR4 C1QBP TXN CPN1 FCN1 FCN2 PROS1 C4BPA THBS1 SELPLG C8A ITGA2 WAS C4A SELE C3AR1 MBL2 CR2 GNA15 F10 IBSP CR1 SPP1 CD40 SERPING1 MASP2 MASP1 CD46 PRKCA PRNP CFD C1S CFH CALORIC RESTRICTION AND AGING%WIKIPATHWAYS_20260510%WP4191%HOMO SAPIENS Caloric restriction and aging MTOR PRKAB2 SIRT1 NAMPT IGF1 PPARGC1A CAFFEINE IN BLOOD VESSELS%WIKIPATHWAYS_20260510%WP5601%HOMO SAPIENS Caffeine in blood vessels MYLK CALM1 ADCY6 RYR2 ADRA1D ADRA1B ADRA1A RYR3 PDE3A GUCY1A2 PPP1R12C HEL-S-80p ADORA2A PDE3B PDE4B PDE4A PDE4D ADCY9 ADORA2B ADCY3 ADCY1 ADCY8 DISORDERS OF MITOCHONDRIAL HOMEOSTATIS DYNAMICS PROTEIN IMPORT AND QUALITY CONTROL%WIKIPATHWAYS_20260510%WP5504%HOMO SAPIENS Disorders of mitochondrial homeostatis dynamics protein import and quality control MCL1 HTRA2 PARK2 PINK1 PYCR2 MIPEP VCP SACS AIFM1 CLPP XPNPEP3 MFN1 MFN2 MICOS13 PLEK UFD1L UBXN1 CLPB FLJ10842 OPA3 GDAP1L1 LONP1 C1QBP PMPCB USP9X PMPCA UBXN6 PAM16 TXN2 OXA1L PPA2 TMEM126A YME1L1 HSPD1 MICU1 SPG7 MFF TIMM50 PITRM1 MSTO1 MARCHF5 ATAD3A DNAJC19 TIMM8A TRAK1 TIMMDC1 GFER COQ5 COQ3 NPLOC4 SFXN4 RTN4IP1 OPA1 TXNRD2 STAT2 TESSADORI BICKNELL VAN HAAFTEN SYNDROME VARIANTS NUCLEOSOME ASSEMBLY%WIKIPATHWAYS_20260510%WP5573%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome variants nucleosome assembly H2BC12 H4C9 HIRA HIST1H4L CHAF1B SMIM40 RBBP4 CHAF1A NUCLEAR RECEPTORS META PATHWAY%WIKIPATHWAYS_20260510%WP2882%HOMO SAPIENS Nuclear receptors meta pathway SLC19A2 TGFB1 JUND SLC39A2 SLC39A1 SLC39A3 IL2 SP1 DNAJB1 JUN PTGR1 CYP4F12 MAFG SCD FASN MAFF SLC2A2 SLC5A1 FGF13 PCK1 SLC39A9 FTH1 SLC39A6 FGF8A SLC39A5 SLC39A8 SLC6A19 CYP2B6 SLC6A18 SLC6A17 SLC6A16 SLC6A13 HEL126 SLC5A6 SLC5A7 SLC5A8 TXN SLC5A9 CES8 EPHA3 HEL-S-10 SLC5A2 SLC6A20 SLC5A3 CCL20 SLC5A4 SLC5A5 SLC2A9 HEL-S-128m SLC6A5 SLC6A7 SERPINA1 SRXN1 SLC2A4 SLC2A6 SLC6A2 SLC2A7 SLC2A8 ME1 SLC2A14 B3GNT5 SLC2A11 SLC2A10 GCC1 ABCC5 PLK2 SLC2A13 SMARCA1 SLC2A12 CPEB4 HEL-S-25 EPB41L4B SLC39A11 ENC1 SLC39A10 EDN2 SLC39A13 TSC22D3 SLC39A12 SLC39A14 CDC42EP3 PMP2 SLC5A12 FGD4 SLC5A10 SRPX2 GPR153 SERTAD2 CAVIN2 NR1H4 KTN1 SLCO2B1 SCNN1A UGT2B4 SLC26A2 ABHD2 KAT2B IP6K3 DNAJC15 UGT2B7 ARL5B SRGN DNAJC7 NAV3 ADGRF4 PRRG4 PPP1R14C S100P NR0B2 SLC7A5 NR3C1 ALOX5AP NR1C2 AHR IL11 CCND1 MYC PDK4 SLC6A3 IFNG CCL2 ACKR3 EPHA2 ALAS1 SRC EGFR FOXO1 DNER CYP3A7 STAT3 TNS4 FGFBP1 MYOF IL1B BIRC3 AMIGO2 POLK GPAM ANGPTL4 GADD45B SLC2A3 BAX GSTM2 GSTM1 CDKN1B GSTT2 HEL-75 GCLC GSTA5 GCLM EP300 MGST1 PTPA CYP1B1 IL12B UGT1A4 HES1 IL12A UGT1A3 UGT1A7 CAP2 IGFBP1 NCOA1 NQO1 SERPINB2 UGT1A1 PTGES3 AIP ALDH3A1 CDC37 CDC2 AHRR CES3 IL17B ANKRD1 THBD CDKN1C SMC1A TNFAIP3 FTL GSTM4 ACOX1 GSTM3 GSTM5 ZIC2 EGR1 TGFBR3 HSP90AB1 CDK4 MGST3 MGST2 SLC6A8 CYP4A11 GSTA4 RGS2 GSTA3 CYP3A4 PTGS2 CYP2C19 CYP2C9 CYP1A2 MFGE8 NCOA6 HEL-S-22 SNAI2 NR1I3 SLC6A9 SLC7A11 HMOX1 SLC6A1 SLC27A1 STOM CPT1A AGER APOA2 APOC3 SLC6A11 NR1H3 NR1C1 DBI KLK15 CYP7A1 APOA5 CYP8B1 ABCG8 FABP1 ABCG5 RXRA CPT2 ABCC3 EHHADH ACADM ABCC2 UGT1A9 ABCB1 PLTP ABCB4 BAAT NRG1 POU5F1 ABCB11 SLCO1B1 SULT1A1 HBEGF SLC27A5 TGFA HGF FKBP5 BHLHB2 SQSTM1 ADH7 SPRY1 PDE4B CYP2A6 CYP1A1 KEAP1 NR1i1 TNF CES2 TGFBR2 CES1 BIRC2 GPX2 TXNRD3 GPX3 NFKB2 NFE2L2 JUNB SULT2A1 NR1i2 PPARGC1A NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20260510%WP299%HOMO SAPIENS Nuclear receptors in lipid metabolism and toxicity NR1B3 RARB ABCD2 CYP4B1 CYP2B6 CYP27B1 CYP24A1 PPARG NR1C2 CYP26A1 CYP2E1 ABCG1 NR1H3 NR1C1 NR1i1 CYP7A1 ABCA1 CYP8B1 ABCG5 CYP4A11 ABCC3 ABCC2 ABCB1 CYP3A4 ABCD3 RARA ABCB4 CYP2C9 CYP1A2 ABCB11 NR1H4 NR1i2 NR1I3 T CELL ACTIVATION SARS COV 2%WIKIPATHWAYS_20260510%WP5098%HOMO SAPIENS T cell activation SARS CoV 2 ZAP70 LTA RELA IRF2BPL BCL2L1 GRAP2 CDKN1A IL12B FOXO3A PLCG1 MAPK3 IL23R IL12A LCP2 PTEN CARD11 PIK3CD CD3G BCL10 ICOS RPTOR CD3E DEPTOR CD3D CCND1 HLA-DRA IL2 STAT4 MLST8 TYK2 IL12RB1 HRAS MAP2K2 IFNG IL23A TSC2 LCK TSC1 PTPRC MYD88 SOS1 NFATC1 IL4 PDPK1 JUN LAT IL17A HLA-DRB1 CTLA4 FYN MTOR RHEB CDKN2A GRB2 IKBKB CCL19 NFKBIA CHUK PPP3CC MAPK1 IKBKG RAF1 CCL28 NFKB1 IFNAR2 TNF PIK3R1 IFNAR1 IFNB1 RICTOR GSK3B BAX CD80 IL18R1 MAP2K1 FOS PRKCQ PI3K AKT MTOR VITAMIN D3 SIGNALING%WIKIPATHWAYS_20260510%WP4141%HOMO SAPIENS PI3K AKT mTOR vitamin D3 signaling TSC2 TSC1 MTOR PRKAA2 RXRA RELA HK3 SLC2A3 CYP24A1 IL10 GSK3B PIK3CA IL12A PFKFB4 CD80 HLA-DRA PDHA1 HEL-S-133P MYC NR1i1 ENDOMETRIAL CANCER%WIKIPATHWAYS_20260510%WP4155%HOMO SAPIENS Endometrial cancer CDKN1A FOXO3A MAPK3 PTEN HEL-S-28 PIK3CD BRAF CCND1 MYC AKT3 HRAS FGF2 MAP2K2 CTNNB1 AXIN2 SOS1 SOS2 PDPK1 PIK3CA TCF7L2 LEF1 AXIN1 EGFR EGF TCF7L1 APC KRAS GRB2 APC2 FGFR3 FGFR2 FGFR1 ARAF MAPK1 RAF1 POLK DDB2 PIK3R3 CTNNA1 PIK3R2 PIK3R1 CTNNA3 NRAS CTNNA2 BAK1 GADD45B BAD GADD45A GADD45G GSK3B BAX CASP9 MAP2K1 FOS ERBB2 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES INTERFERON INDUCTION%WIKIPATHWAYS_20260510%WP4880%HOMO SAPIENS Host pathogen interaction of human coronaviruses interferon induction IRF9 IKBKE TICAM1 IRF3 TLR7 RIGI MAPK8 JAK1 IKBKB NFKBIA STAT1 CHUK TRAF6 MAPK14 IKBKG NFKB1 TYK2 IFNAR2 MAVS TRAF3 IFNAR1 MYD88 RIPK1 STAT2 JUN MAP3K7 EIF2AK2 OAS1 OAS2 IFIH1 FOS TBK1 CELIAC DISEASE MECHANISM AND THERAPIES%WIKIPATHWAYS_20260510%WP5562%HOMO SAPIENS Celiac disease mechanism and therapies ITGA4 DHODH IFNG IL15 TNF EGFR IL2 IL-21 F2RL1 ITGB7 TARGETING YAP IN PANCREATIC DUCTAL ADENOCARCINOMA PDAC %WIKIPATHWAYS_20260510%WP5495%HOMO SAPIENS Targeting YAP in pancreatic ductal adenocarcinoma PDAC YAP1 CYR61 PRKAA2 CTGF PRKAG1 PRKAG2 RHOD PRKAA1 PRKAG3 MOB1A TEAD2 TEAD3 TEAD4 RHO HMGCR PRKAB2 LATS1 PRKAB1 LATS2 STK4 RHOB ARHA NEURAL CREST DIFFERENTIATION%WIKIPATHWAYS_20260510%WP2064%HOMO SAPIENS Neural crest differentiation HES5 OLIG2 SOX10 FOXD3 NEUROG1 DMBX1 OLIG1 MPZ MIA OLIG3 ISL1 HOXB1 HDAC3 HDAC9 DLL3 HES1 HAND1 DLX5 DLL4 TFAP2A HDAC11 PRTG PMP22 GJB1 LHX5 PAX3 PAX7 MYC ASCL1 GBX2 FGF2 HDAC5 TLX2 CTNNB1 HDAC6 MSX1 FGF8 TCF4 AXIN2 SMAD1 TBX6 DVL1 DVL2 DVL3 HDAC2 AXIN1 HDAC1 GFAP ZIC5 DCT CTBP2 RBPJ WNT1 HEY2 LHX1 CDH2 TFAP2B ITGB1 TCF7L1 FGF8A NOTCH3 ID1 WNT8A HDAC7 FGFR3 BMP4 FGFR2 PHOX2B FGFR1 SNAI1 FZD3 WNT3A NFKB1 RHOB BMP7 MBP CDH6 ZIC1 HOXA1 HDAC8 NOTCH2 SOX9 NOTCH1 GSK3B SOX5 COL11A2 COL2A1 NFKB2 HDAC10 TWIST1 MSX2 MYB SNAI2 ID SIGNALING%WIKIPATHWAYS_20260510%WP53%HOMO SAPIENS ID signaling CDK2 ID3 PAX2 RBL2 RBL1 ID1 MYOD1 ELK3 CCNE1 ID2 RB1 PAX5 PAX8 16P12 2 COPY NUMBER VARIATION SYNDROME 520KB %WIKIPATHWAYS_20260510%WP5510%HOMO SAPIENS 16p12 2 copy number variation syndrome 520kb MAPK12 PRKAA2 MAPK11 NDUFS8 MAPK3 NDUFS3 POLR3E RPTOR RAB5IF RPS6KB1 MOSMO TRPM7 MAPK14 PDZD9 SDR42E2 VWA3A MLST8 CDC2 MAP2K2 CDK2 CALM1 NDUFA9 UQCRB MTOR UQCR11 UQCR10 CYB UQCRH EEF2 UQCRQ UQCRC1 UQCRFS1 CYC1 UQCRC2 CDR2 PRKAB2 PRKAB1 MAPK1 MAPK13 RPS6KA1 PRKAG1 COX7C PRKAG2 EEF2K COX5A PRKAG3 PRKAA1 COXFA4 MAP2K1 CDH18 CHROMOSOMAL AND MICROSATELLITE INSTABILITY IN COLORECTAL CANCER %WIKIPATHWAYS_20260510%WP4216%HOMO SAPIENS Chromosomal and microsatellite instability in colorectal cancer BBC3 CSNK1A1L BCL2L11 EXOC2 MAPK9 MAPK8 CDKN1A MAPK3 TGFB1 BRAF CCND1 SMAD2 MYC SMAD4 AKT3 CYCS ARHA TGFBR1 BCL2 CTNNB1 AXIN2 JUN TCF7L2 LEF1 AXIN1 APPL1 TBK1 CSNK1A1 NTN1 MAPK10 TCF7L1 APC MSH2 MSH3 REL KRAS MSH6 RAC3 APC2 BIRC5 ARAF MAPK1 RAC1 RAF1 POLK DDB2 TGFBR2 BAK1 GADD45B PTGS2 BAD PMAIP1 GADD45A GADD45G GSK3B BAX CASP9 CASP3 DCC MAP2K1 RALA FOS RALB CYSTEINE AND METHIONINE CATABOLISM%WIKIPATHWAYS_20260510%WP4504%HOMO SAPIENS Cysteine and methionine catabolism pcap HEL-S-64p CBS MAT1A SQOR MTR CDO1 GCLC CTH ETHE1 SUOX HEL-S-61p THYMIC STROMAL LYMPHOPOIETIN TSLP SIGNALING%WIKIPATHWAYS_20260510%WP2203%HOMO SAPIENS Thymic stromal lymphopoietin TSLP signaling STAT3 FYN YES1 GAB2 RELA TEC MAPK9 MAPK8 MAPK3 JAK1 LYN STAT5B NFKBIA STAT1 RPS6 CRLF2 MAPK1 MAPK14 BTK TSLP STAT4 NFKB1 MAP2K2 LCK RELB PTPN11 NFKB2 SRC IL7R MAP2K1 EIF4EBP1 FES MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20260510%WP289%HOMO SAPIENS Myometrial relaxation and contraction pathways CREB1 CRH CRHR1 PLCG2 ADM PLCG1 IGFBP1 IGFBP5 SP1 ACTG1 HEL-S-14 JUN MAFF ATF2 ETS2 PS1TP5BP1 NFKB1 HEL2 OXTR OXT SLC8A1 RGS4 RGS5 RGS2 GJA1 RGS1 RGS6 RGS7 PRKCH CALCA PRKCB PRKCE PRKCA CACNB3 ADCY9 PRKAR1B PRKAR1A PRKCQ PRKD1 ITPR2 PRKCZ GRK5 GRK4 SFN RLN1 GNG12 GNG11 GNG13 PKIB PKIA GNB2 GNB1 CRCP GABPB1 GNAS RXFP2 GNB4 IGFBP4 GNB3 CNN2 GNB5 CALD1 PKIG DGKZ IGFBP6 CALM1 RYR1 RAMP2 RYR2 RAMP3 ATP2A2 CORIN GUCA2B ARRB2 GUCA2A ACKR5 RYR3 GNGT1 YWHAQ HEL-S-1 YWHAG ACKR3 YWHAZ RAMP1 PLCB3 RGS18 RGS17 CAMK2D RGS14 RGS16 CAMK2A MYL2 ADCY3 ADCY1 ADCY8 ADCY6 ATF3 GNG3 GNG2 GNG5 GNG4 GNG7 RGS20 ATF5 GNG8 CAMK2G GABPA HEL-S-21 ATF1 ATF6B IL1B PDE4B CREB3 RGS10 RGS11 PDE4D MYLK2 ATF4 IL6 IGFBP2 LPAR1 ACTA1 ACTA2 MYL4 FOS ACRYLAMIDE BIOTRANSFORMATION AND EXPOSURE BIOMARKERS%WIKIPATHWAYS_20260510%WP4233%HOMO SAPIENS Acrylamide biotransformation and exposure biomarkers CYP2E1 PERTURBATIONS TO HOST CELL AUTOPHAGY INDUCED BY SARS COV 2 PROTEINS%WIKIPATHWAYS_20260510%WP4936%HOMO SAPIENS Perturbations to host cell autophagy induced by SARS CoV 2 proteins CALCOCO2 EIF4B VPS41 MTOR PRKAA2 RHEB ATG9A SQSTM1 ULK1 LAMP2 RPS6 DKFZp762B153 OPTN RPTOR RPS6KB1 DEPTOR HEL-S-30 VPS39 MLST8 ATG5 ATG3 TMEM59 NBR1 ATG12 PPP1R9A VAMP8 ATG16L1 AKT1S1 LARP1 VPS18 GABARAPL2 VPS33A RB1CC1 VPS11 RAB7A LAMTOR1 VPS16 APOB ATG2B TESSADORI BICKNELL VAN HAAFTEN SYNDROME 3 OVERVIEW PATHWAY%WIKIPATHWAYS_20260510%WP5575%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome 3 overview pathway TBP H4C9 MED23 TAF13 TAF8 MED27 LUPUS THERAPIES%WIKIPATHWAYS_20260510%WP5560%HOMO SAPIENS Lupus therapies TNLG7A C4B_2 C2 IL12B IL12A CD40LG HEL-S-62p C4A C1QC IL6R IL17B IFNG IL23A IL25 CD19 IL6 MS4A1 CD40 C1QA IL17F IL17D IL17C IL17A CD80 C1QB CD22 TP53 NETWORK%WIKIPATHWAYS_20260510%WP1742%HOMO SAPIENS TP53 network BCL2 OTX2 BBC3 TNFSF10 CDKN2A MDM2 TP63 BOK GADD45A PMAIP1 CDKN1A TP73 BAX ATM SUMO1 MYC SPINA BIFIDA%WIKIPATHWAYS_20260510%WP5150%HOMO SAPIENS Spina bifida MAT1A MTR MTHFD1 DNMT3B AHCYL2 MTRR SHMT1 AMINO ACID METABOLISM%WIKIPATHWAYS_20260510%WP3925%HOMO SAPIENS Amino acid metabolism TDO2 GLS ALDH7A1 LARS2 GLUD1 ACO2 TPO DLD DBH G6PC2 PDK4 DDC TH MAOA EHHADH ACADM PDHX SUCLG1 BCAT1 PIG59 PPM1L HEL-S-61p ADH5 P4HA2 IARS FARSB FTCD ARG2 FH PDHA1 HEL-S-32 SDHA HEL-S-26 CS ACLY PC PNMT OGDH CBS PCK1 EPRS1 HAL GPT2 CAD HDC ADH1C ADH7 OTC HEL-S-30 HEL-S-53e HEL-S-133P ARG1 HEL-S-4 ASS1 SRM SMS ASNS ALDH18A1 MDH2 GOT2 ACSS1 RARS1 MARS2 HEL-S-64p MCCC1 HEL-75 CTH GCLM HMGCL TPH1 TRYPTOPHAN KYNURENINE PATHWAY IN POST COVID SYNDROME%WIKIPATHWAYS_20260510%WP5549%HOMO SAPIENS Tryptophan kynurenine pathway in post COVID syndrome IFNG DDC AADAT TNF HAAO GOT2 IDO1 IL6 TDO2 AFMID KYAT3 KYNU KYAT1 KMO IDO2 IFNB1 IL1B AHR IFNA6 PKC GAMMA CALCIUM SIGNALING IN ATAXIA%WIKIPATHWAYS_20260510%WP4760%HOMO SAPIENS PKC gamma calcium signaling in ataxia CACNA1A GNA14 PLCB4 GNA15 TRPC3 RYR3 GNA11 GRIA3 GRIA2 PLCB1 PLCB3 CA8 ATP2B2 HOMER3 PLCB2 GRIA4 NANOMATERIAL INDUCED APOPTOSIS%WIKIPATHWAYS_20260510%WP2507%HOMO SAPIENS Nanomaterial induced apoptosis DIABLO BCL2 APAF1 HTRA2 CASP8 CASP6 TNFSF6 FADD BAK1 BAX CASP9 AIFM1 CASP3 PRF1 FAS CYCS BLOOD CLOTTING CASCADE%WIKIPATHWAYS_20260510%WP272%HOMO SAPIENS Blood clotting cascade PLG VWF SERPINF2 F3 HEL-S-78p F9 F5 F10 F8 F11 F13B PLAT KLNA1 F2 KLKB1 SERPINB2 FGA F7 16P11 2 DISTAL DELETION SYNDROME%WIKIPATHWAYS_20260510%WP4950%HOMO SAPIENS 16p11 2 distal deletion syndrome INSR NFATC2 RABEP2 PLN ATP2A1 GRB2 SDCCAG8 VAV2 TRAF1 RAB5A IFITM1 SH2B1 MPL HEL-S-62p RAB4A CD82 KDR TRAF2 CD19 PRMT1 CR2 IL4 SLN NFATC2IP LAT TUFM ATXN2L SPNS1 CD81 OVERVIEW OF PROINFLAMMATORY AND PROFIBROTIC MEDIATORS%WIKIPATHWAYS_20260510%WP5095%HOMO SAPIENS Overview of proinflammatory and profibrotic mediators IL1RN CSF2 CSF1 CXCL13 IL36A IL9 IL36B CCL23 IL12B IL1A IL12A TGFB1 IL24 IL2 IL36RN IL17B IL37 IL36G IL1F10 IL25 IL17D IL17C IFNA1 CXCL14 IF1AA9 CXCL16 IFNA13 CSF3 IFNA14 IFNA16 IL7 CCL4L2 IFNA17 IFNA10 XCL1 CCL11 IFNA21 CCL1 CCL19 CXCL6 CCL17 CXCL9 CCL15 CCL25 CCL24 CXCL17 CCL22 CXCL1 CCL21 CXCL3 CCL20 CXCL2 IL33 TSLP CXCL5 CCL28 NFKB1 IFNA4 CCL26 IFNA7 CX3CL1 IFNA6 IFNA2 IFNA8 CCL14 CCL13 CCL3L3 OSM SPP1 CCL27 IFNB1 PPBP CCL18 PF4 CCL16 CNTF EBI3 MMP3 LTA IL13 IL10 IF2B1 IL15 IL27 IL11 IF2G IL-21 CCL8 CCL7 CCL5 EPO CCL4 CCL3 TNFSF13 IFNG CCL2 IL23A IL3 CXCL11 CXCL12 AREG LIF IL4 IL17F IL17A IF2D IFNW1 IF1IB1 PF4V1 IL19 XCL2 IFNL2 IFNL3 IL31 TNLG7A IL1B CTF1 IL18 MMP9 TNF IL6 IFNK CXCL8 VEGFA IL5 LEUKOCYTE INTRINSIC HIPPO PATHWAY FUNCTIONS%WIKIPATHWAYS_20260510%WP4542%HOMO SAPIENS Leukocyte intrinsic Hippo pathway functions KNSTRN YAP1 RAB13 FERMT3 FYB1 CCR7 STK38L PRDM1 TEAD2 TEAD3 FOXO3A FOXO4 MAPK14 RAC1 ARHA FOXP3 WWTR1 CD19 LPL YWHAQ MOB1A TEAD4 RAP1A LATS1 FOXO1 LATS2 FOXO6 ALANINE AND ASPARTATE METABOLISM%WIKIPATHWAYS_20260510%WP106%HOMO SAPIENS Alanine and aspartate metabolism PC ASL ASPA GOT2 AGXT GAD1 GPT GAD2 ASS1 ABAT ENDOPLASMIC RETICULUM STRESS RESPONSE IN CORONAVIRUS INFECTION%WIKIPATHWAYS_20260510%WP4861%HOMO SAPIENS Endoplasmic reticulum stress response in coronavirus infection PPP1R15A PPP1R15B PPP1R13B PPP1R11 PPP1R14C PPP1R2 PPP1R8 PPP1R16B PPP1R14A PPP1R14B MAPK8 PPP1R16A EIF2S1 PPP1R3G HEL-S-80p PPP1R3F PPP1R3E PPP1R1C PPP1R3D PPP1R14D HEL-S-89n PPP1R10 MAP1LC3A ATF4 PPP1R7 BCL2 PPP1R1B PPP1R1A PPP1R9A MBTPS1 PPP1R12B PPP1R12C PPP1R3A MBTPS2 PPP1R3C PPP1R3B DDIT3 EIF2AK2 XBP1 EIF2AK1 PPP1CC ERN1 PENTOSE PHOSPHATE PATHWAY IN SENESCENT CELLS%WIKIPATHWAYS_20260510%WP5043%HOMO SAPIENS Pentose phosphate pathway in senescent cells RPIA HEL-S-304 PRPS1L1 DERA RPE WNT SIGNALING IN KIDNEY DISEASE%WIKIPATHWAYS_20260510%WP4150%HOMO SAPIENS Wnt signaling in kidney disease MAPK10 WNT2B WNT5B WNT9B MAPK9 FZD1 WNT16 MAPK8 NPHP3 WNT3 INVS WNT10B WNT10A FZD3 FZD2 FZD5 FZD4 WNT3A WNT7B FZD7 FZD9 ARHA WNT7A FZD8 CTNNB1 DVL1 DVL2 DVL3 WNT4 LRP5 LRP6 WNT1 COCAINE METABOLISM%WIKIPATHWAYS_20260510%WP2826%HOMO SAPIENS Cocaine metabolism BCHE CES2 CES1 CYP3A4 LEPTIN AND ADIPONECTIN%WIKIPATHWAYS_20260510%WP3934%HOMO SAPIENS Leptin and adiponectin ADIPOR2 PRKAG1 PRKAB1 ADIPOR1 ACACA CPT1A PRKAA1 LEPR LEP LUPUS PATHOGENESIS%WIKIPATHWAYS_20260510%WP5559%HOMO SAPIENS Lupus pathogenesis TLR4 TNLG7A IL6 TLR7 PDCD1 CD40 ICOS IL17A CD40LG CD80 TNFRSF13C BCR ICOSLG IFNA2 TLR9 NON HOMOLOGOUS END JOINING%WIKIPATHWAYS_20260510%WP438%HOMO SAPIENS Non homologous end joining POLL WRN NHEJ1 POLM PRKDC XRCC5 EGFR TYROSINE KINASE INHIBITOR RESISTANCE%WIKIPATHWAYS_20260510%WP4806%HOMO SAPIENS EGFR tyrosine kinase inhibitor resistance BCL2L11 BCL2L1 PLCG2 FOXO3A PLCG1 JAK1 MAPK3 PTEN PIK3CD IGF1R RPS6 RPS6KB1 BRAF RPS6KB2 CCND1 MYC AXL AKT3 KDR HRAS FGF2 IL6R PDGFRA MAP2K2 BCL2 SOS1 SOS2 MET PDPK1 NRG1 PIK3CA NRG2 SHC1 SRC EGFR SHC4 SHC3 TGFA ERBB3 IGF1 EIF4EBP1 EGF STAT3 MTOR PDGFD HGF PDGFC PDGFA KRAS GRB2 FGFR3 FGFR2 RRAS2 ARAF RRAS MAPK1 RAF1 SHC2 PIK3R3 PIK3R2 PIK3R1 NRAS IL6 BAD GSK3B NF1 EIF4E BAX VEGFA PRKCB PRKCA MAP2K1 ERBB2 ROTENONE METABOLISM%WIKIPATHWAYS_20260510%WP5486%HOMO SAPIENS Rotenone metabolism CYP3A4 CYP2C19 OMEGA 6 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260510%WP5424%HOMO SAPIENS Omega 6 fatty acids in senescence MAPK11 PTGIS PRXL2B DECR1 CDKN1A ALOX5AP PTGES DPEP2 HEL-S-53e PTGES3 CYP4F8 ALOX12 ALOX15 SIRT1 HEL-S-298 HPGD PTGS2 GPX1 PTGS1 ELOVL5 LTC4S ELOVL2 SLCO2A1 ALOXE3 ALOX15B FADS2 ALOX5 EPHX2 RB1 FADS1 NAT2 HEL-S-22 AKR1B1 NETWORK MAP OF SARS COV 2 SIGNALING%WIKIPATHWAYS_20260510%WP5115%HOMO SAPIENS Network map of SARS CoV 2 signaling TRPM2 PARP2 CXCL13 INTS4 IL9 MAPK8 IL1A CARD11 CASP5 FGF2 ACTG1 LBP HBB HBD JUN CD14 CXCL16 IL7 CCR6 PS1TP5BP1 CCL11 PMPCB CCL1 CCL15 CCL22 CCL21 CCL20 CCL26 PITRM1 GABARAPL2 CCL27 STEAP3 IGLL1 PIAS1 MIB1 ADAM9 IL10 IF2B1 CCR5 CD3G ULK1 TPO DKFZp762B153 RPTOR AHR CD3E DEPTOR HLA-DRA IL-21 LGALS3BP CCL8 MLST8 CCL5 CCL4 CCL3 IFNG CCL2 LCK MMP25 HIF1A CXCL12 AKT1S1 MYD88 IL4 IL17A NTRK1 OAS2 CD8B1 IRF9 CD8A FYN MTOR PTPN6 MOV10 FAM83A RHEB CXCR1 BIRC5 C1QBP IL1B HEL117 GTSE1 VPS36 RAC1 WDR74 APOD HEL103 PRG3 HRG CTSZ SERPINA10 SDF2 GP1BA IL16 TLE3 HMFT1766 OS9 APOL1 RTN4 COQ8B SRP19 NRF HP CLCC1 GTF2F2 TBKBP1 IFI6 UGCGL2 G3BP2 NPTX1 MDN1 NEK9 TRO TRIM59 ITIH3 ATE1 CD2 ATP13A3 FAM98A IL5 TNFSF10 EIF4A2 IL12A CD226 CCNB2 CCNB1 ITIH4 CDC2 SRP54 SMAD1 DKFZp781O1323 NFATC3 HLA-DRB1 IRAK1 HEL-S-81p EGR1 CXCL6 CXCL9 IFITM1 RRAS TRAF6 CXCL1 IKBKG CXCL3 IL33 CXCL2 RRM2 CXCL5 C8A TRAF2 CEBPB IL8RB LARP1 PTGS2 IFNB1 MX1 TP53I3 SIGMAR1 PF4 IL18RAP IL1R2 IFITM3 C1S PRKCQ CFH ZAP70 C1R CFI CASP8 CFP IL13 JAK1 CRP STAT1 RPS6 IFI27 APOA2 TF VPS18 VPS33A VPS11 APOH VPS16 HLA-DRB5 ITCH SELP BST2 FGA IFIH1 EIF4EBP1 APOC1 TBK1 CTSL CD163 IRF3 VPS41 HEL-S-78p ALB SAA1 SAA2 RIGI IFI44L CPN1 GGH IFIT1 CAMK4 TOMM70 HEL-S-72p IL18 NLRP1 TNF ACE2 TGFBR2 DDIT4 MAVS IL6 TRAF3 NLRP3 HEL-S-130P CXCL8 EIF4E NFKB2 CASP9 CASP3 JUNB FOS HEMESYNTHESIS DEFECTS AND PORPHYRIAS%WIKIPATHWAYS_20260510%WP5169%HOMO SAPIENS Hemesynthesis defects and porphyrias ALAS2 ALAS1 FECH HMBS UROD UROS CPOX PDGFR BETA PATHWAY%WIKIPATHWAYS_20260510%WP3972%HOMO SAPIENS PDGFR beta pathway STAT3 PIK3R1 GRB2 MAPK8 SOS1 MAP2K4 PLCG1 JUN MAPK3 JAK1 PIK3CA STAT5B SHC1 PRKCB MAP3K1 STAT1 PRKCA RAF1 MAP2K1 EIF2AK2 FOS HRAS GASTRIC CANCER NETWORK 1%WIKIPATHWAYS_20260510%WP2361%HOMO SAPIENS Gastric cancer network 1 ESM1 TOP2A AURKA MYBL2 RUVBL1 ECT2 KIF20B E2F7 NUP107 H3F3B APC S100P ACTL6A NOTCH1 UBE2C CEP192 LIN9 H4C9 INO80D HCTP4 GATD3 KIF15 SMOC2 CENPF GPCRS CLASS B SECRETIN LIKE%WIKIPATHWAYS_20260510%WP334%HOMO SAPIENS GPCRs class B secretin like PTH1R GIPR GCGR SCTR VIPR2 GPR64 CRHR1 PTH2R CRHR2 GHRHR ADGRE2 ADCYAP1R1 CALCR ADGRL4 ADGRL2 ADGRL3 CALCRL ADGRE5 ADGRL1 GLP1R PLURIPOTENT STEM CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260510%WP2848%HOMO SAPIENS Pluripotent stem cell differentiation pathway EGF CSF1 WNT2B NODAL FGF10 HGF PDGFA SHH CXCR1 INHBA GDF5 BMP4 TGFB1 FLT3LG TPO FGF7A NTF4 IL11 WNT3A WNT7B NT5E EPO FGF2 IL6R LEFTY1 KITLG TF FGF8 TNFSF11 IL3 IL6 NOG DKK1 KIT NOTCH1 FST CSF1R VEGFA ALK CNTF WNT1 INS IGF1 SPHINGOLIPID PATHWAY%WIKIPATHWAYS_20260510%WP1422%HOMO SAPIENS Sphingolipid pathway CERK PPP2CA PLPP1 SGMS1 SPHK1 SGMS2 UGT8 UGCG KDSR GBA2 CERS2 ASAH2 ACER1 SPTLC3 SERINC1 CERT1 SPHK2 SGPP2 SGPL1 SPTLC2 SPTLC1 CERS3 CERS5 CERS6 TRANSCRIPTION CO FACTORS SKI AND SKIL PROTEIN PARTNERS%WIKIPATHWAYS_20260510%WP4533%HOMO SAPIENS Transcription co factors SKI and SKIL protein partners HDAC3 SKI HDAC1 LATS1 SIN3A LATS2 MERTK TEAD2 SKIL TEAD3 TEAD4 NF1 DRAVET SYNDROME%WIKIPATHWAYS_20260510%WP5200%HOMO SAPIENS Dravet syndrome FGF13 PRR5 MTOR MAPK11 SCN3B CHD2 SNTA1 KCNA2 PCDH19 SCN3A SCN1A SCN2B STXBP1 NFKB1 SCN8A MLST8 SCN2A SCN1B SCN4B CALM1 TNF MAPKAP1 RICTOR PIK3CA PRKCA CAMK2A HCN1 INDUCTION OF AUTOPHAGY AND TOLL LIKE RECEPTOR SIGNALING BY GRAPHENE OXIDE %WIKIPATHWAYS_20260510%WP5336%HOMO SAPIENS Induction of autophagy and toll like receptor signaling by graphene oxide IFNG TNF IRF3 TLR4 TRAF6 MYD88 NFKB1 MAP1LC3A IFNB1 TLR9 MAMMARY GLAND DEVELOPMENT PUBERTY STAGE 2 OF 4%WIKIPATHWAYS_20260510%WP2814%HOMO SAPIENS Mammary gland development puberty stage 2 of 4 TIMP1 EGF CCND1 HEL113 PGR MYC AREG FOSL1 ERBB2 SARS CORONAVIRUS AND INNATE IMMUNITY%WIKIPATHWAYS_20260510%WP4912%HOMO SAPIENS SARS coronavirus and innate immunity IRF9 IKBKE IFNA13 TICAM1 IFNA14 IRF3 IFNA16 IFNA17 TLR3 RIGI IFNA10 IFNA21 JAK1 STAT1 IFNA4 IFNA7 TYK2 IFNA6 IFNA2 IFNA8 IFNAR2 ACE2 MAVS TRAF3 IFNAR1 IFNB1 STAT2 IFNA1 IF1AA9 IFIH1 TBK1 COMPLEMENT MEDIATED INFLAMMATION OF PULMONARY ALVEOLUS IN COVID 19 HYPOTHETICAL PATHWAY %WIKIPATHWAYS_20260510%WP5148%HOMO SAPIENS Complement mediated inflammation of pulmonary alveolus in COVID 19 hypothetical pathway C9 MASP2 C3AR1 FCN1 ACE2 C5AR1 HEL-S-62p COLEC11 C8A C6 C7 GLP 1 FROM INTESTINE AND PANCREAS AND ROLE IN GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260510%WP5452%HOMO SAPIENS GLP 1 from intestine and pancreas and role in glucose homeostasis GCG PCSK2 INS GLP1R PCSK1 MIRNA TARGETS IN ECM AND MEMBRANE RECEPTORS%WIKIPATHWAYS_20260510%WP2911%HOMO SAPIENS miRNA targets in ECM and membrane receptors LAMA4 XB SDC2 LAMB2 COL5A3 COL5A2 ITGB6 COL4A1 COL1A2 COL4A2 ITGA1 COL3A1 THBS2 THBS1 LAMC1 ITGB5 COL6A1 NETRIN UNC5B SIGNALING%WIKIPATHWAYS_20260510%WP4747%HOMO SAPIENS Netrin UNC5B signaling YAP1 INPP5D NTN1 FYN PTPA ROBO4 IL10 IL1A ALPL MAPK3 PTK2B MYF5 PPP2R1B MAPK1 MAPK14 DCSTAMP RAC1 RAF1 KDR RLF ARHA NTN3 SELE PLEKHH1 UNC5B CCL2 MAP2K2 CIP2A TNF VCAM1 CTGF NEO1 AGAP2 PTPN11 JUN COL1A1 PIK3CA ITGB4 SRC PRKCA CASP3 ARHGEF12 MAP2K1 RGMA MECP2 AND ASSOCIATED RETT SYNDROME%WIKIPATHWAYS_20260510%WP3584%HOMO SAPIENS MECP2 and associated Rett syndrome NCOR1 CREB1 TET2 REST FUS BCL6 DLX5 PTEN IGF1R RPS6 GAD1 IGF2 YBX1 FGF2 SP1 PSIP1 RBFOX1 TET3 DLX6 TET1 NREP FUT8 PRPF38A HNRNPH1 POU4F1 HNRNPF TAF1 FOXG1 SST HDAC1 CAMK2A IGF1 APOC2 MEF2C CNP MTOR SIN3A GRIA3 FKBP5 POU3F2 GPRIN1 CDON EZH2 CTCF FGF7A MBP CEBPD MYT1 BDNF HEL-S-20 SGK1 FGF5C OPRK1 NF1 TAP1 UBE3A SMC3 GRIN1 SP3 GRIA4 TARDBP FIBRIN COMPLEMENT RECEPTOR 3 SIGNALING%WIKIPATHWAYS_20260510%WP4136%HOMO SAPIENS Fibrin complement receptor 3 signaling PLG TICAM1 IRF3 TLR4 HEL-S-78p RELA TLR3 REL NOS2 IL12B PLAT IKBKB SYK FCER1G CHUK ITGAM TYROBP TRAF6 CXCL3 IKBKG IRAK4 NFKB1 ARHA LY96 CCL2 TNF IL6 LBP MYD88 TIRAP IFNB1 PIK3CA SRC CD14 TICAM2 IRAK2 IRAK1 FGA INTERFERON MEDIATED SIGNALING%WIKIPATHWAYS_20260510%WP4558%HOMO SAPIENS Interferon mediated signaling IRF9 IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 IFNA21 JAK1 STAT1 IFNA4 IFNGR1 IFNA7 IL10RB TYK2 IFNA6 IFNA2 IFNLR1 IFNA8 IFNAR2 IFNG PIK3R1 IFNAR1 IFNE IFNK IFNL4 IFNB1 STAT2 PIK3CA PRKCA IFNA1 IFNGR2 IFNW1 IF1IB1 IF1AA9 IFNL2 IFNL3 TRANSCRIPTIONAL REGULATION OF MEMORY B CELL DIFFERENTIATION%WIKIPATHWAYS_20260510%WP5491%HOMO SAPIENS Transcriptional regulation of memory B cell differentiation STAT3 TLR4 TLR7 BCL6 TLR3 CDKN2A CD79B BCL2L1 TCF3 CDKN1A SPI1 LYN EZH2 SYK TNFRSF13C POU2F2 MYC NFKB1 TLR10 CD79A ID3 IRF4 TCF4 IL6 IL21R CD40 SPIB POU2AF1 CCND3 CDKN1B TLR8 TLR5 ICOSLG BCR TLR1 CCND2 MEF2C IRF8 MEF2B TLR9 NICOTINE METABOLISM IN LIVER CELLS%WIKIPATHWAYS_20260510%WP1600%HOMO SAPIENS Nicotine metabolism in liver cells AOX1 CYP2A6 UGT1A9 CYP2B6 UGT1A4 MODULATION OF PI3K AKT MTOR SIGNALING BY BIOACTIVE SPHINGOLIPIDS%WIKIPATHWAYS_20260510%WP5192%HOMO SAPIENS Modulation of PI3K Akt mTOR signaling by bioactive sphingolipids ASAH2 PIK3CA CERK TSC1 MTOR IGF1R S1PR1 SPHK2 S1PR3 HIF1A CERS1 NFKB1 FANCONI ANEMIA%WIKIPATHWAYS_20260510%WP5465%HOMO SAPIENS Fanconi anemia FANCB MRE11A FANCE NBN FANCF BRCA2 RAD51C FAAP24 BRCA1 CENPX CENPS SMARCA4 PTEN ERCC1 HEL-S-125m SLX4 UBE2T FANCG FAN1 CEBPD RFWD3 FANCD2 ATR BRIP1 FANCM FANCL USP1 FANCA FANCC DCLRE1B CTDP1 PALB2 UHRF2 MCM2 MEN1 ATM EGFR MAD2L2 RAD50 UHRF1 REV1 RAD51 GPCRS OTHER%WIKIPATHWAYS_20260510%WP117%HOMO SAPIENS GPCRs other EDNRA C5AR2 HTR2A GPR83 HTR1F ADRB2 GHRHR ADGRE2 ADGRL2 ADGRL3 CCR5 CNR1 HTR7 CXCR3 ADRA1D DRD4 F2R GPR183 OR1G1 OR2M4 GPR61 GPR143 GPR62 CELSR1 GRPR CELSR3 RXFP3 GPR176 GPR132 GNRHR GPR135 ADGRV1 ALG6 OR1F1 OR2H1 TAAR5 OR1J2 TAAR2 OR1N1 GPR162 CXCR1 CCR2 OR5AC2 CCKBR FSHR ADGRF5 VN1R1 SSTR2 OR10A2 OR6C3 OR3A3 SMO OR6C2 OR10A5 OR3A1 OR8G1 OR1E1 GPR88 GPR84 MCHR2 FY OR2B6 NTSR1 OR5D3 P2RY13 GPR17 P2RY11 CHRM2 OR2F1 CHRM3 GPR55 EMR3 ADGRD1 OR2A5 LGR6 OR2A4 GPR18 OR7E24 IL8RB DRD3 UTS2R PTGFR ADORA2A S1PR1 CELSR2 CYTOKINE CYTOKINE RECEPTOR INTERACTION%WIKIPATHWAYS_20260510%WP5473%HOMO SAPIENS Cytokine cytokine receptor interaction IL1RN CSF2 CSF1 CXCL13 IL2RG IL36A GDF8 IL9 IL36B IL9R IL1R1 CCL23 IL1A TGFB1 IL24 CD40LG ACVRL1 IL2 TNLG1B IL1RL2 IL36RN IL37 IL36G TNFRSF10B IL1F10 IL25 IL17D IL17C CXCL14 CXCL16 CCR10 CCR1 XCR1 CSF3 IL7 CCR8 CCL4L2 CCR7 CCR6 CCR4 CCR2 XCL1 CCL11 CXCR5 CXCR6 CCL1 CCL19 CCL15 CCL25 TNFRSF14 CCL24 CCL22 CCL21 CCL20 CCL28 PRLR CCL26 GH1 BMP3 CCL14 CCL13 GDF10 IL13RA1 CCL27 CCL18 PRL NODAL IL10 IL15RA IF2B1 IL23R IL15 CCR5 IL27 TPO IL11 IF2G CXCR4 IL-21 IL27RA CCL8 IFNGR1 CCL7 CCL5 IL6R TGFBR1 CCL4 CCL3 INHBB IFNG CCL2 IL23A TWEAK TNFRSF12A IL3 ACVR2A CXCL11 CXCL12 IL2RB IL21R ACKR3 IL4 CSF1R IL2RA IL17F IL17A IF2D IFNW1 IF1IB1 PF4V1 XCL2 TACI IFNL2 NGFR IFNL3 IL31 CXCR1 ANP32B TNFRSF13C TNLG5A TNFRSF25 TNFRSF21 IFNK IFNGR2 IL5 LEPR TNFSF10 AMHR2 GDF5 TNFRSF9 ACVR1B CNTFR MPL GHR IL11RA IL20RA IL20RB IL10RB IL10RA IFNLR1 IL17B IL22RA1 INHA IL17RC BMP6 GDF9 TNFRSF1B BMPR1A BMPR2 BMP15 GDF15 AMH CCR3 ACVR1 CSF3R ACVR2B CXCL6 CXCL9 CXCL17 CXCL1 CXCL3 IL33 CXCL2 TSLP CXCL5 TNFRSF10C CX3CL1 IFNA2 IFNAR2 BMP10 gdf7 IFNAR1 TNFSF14 IL8RB GDF1 GDF6 CD27 RELT TNFRSF10A IFNB1 GHB2 CD40 CLCF1 NGF TNLG8A TNFRSF8 CSF2RA PPBP IL13RA2 TNFRSF17 PF4 INHBC IL17RB BMP5 IL17RA IL18RAP INHBE IL7R ACVR1C CNTF ACKR4 IL1R2 TNFRSF1A IL18R1 CX3CR1 LTA TNFSF6 IL5RA IL13 CSF2RB TNFRSF19 IL6ST FAS IL12RB1 GDF11 EPO TNFRSF11B GDF3 EPOR TNFRSF11A TNFSF11 IL3RA LIF IL19 LTB TNLG7A TNLG7C INHBA BMP4 EDAR IL1RL1 IL34 TNFRSF4 TNFRSF18 IL18 BMP7 LEP TNF TGFBR2 IL6 TNLG2B CXCL8 BMP8B LTBR PEROXIREDOXIN 2 INDUCED OVARIAN FAILURE%WIKIPATHWAYS_20260510%WP4873%HOMO SAPIENS Peroxiredoxin 2 induced ovarian failure BAX MAPK10 HSD3B2 PARP2 CASP3 HEL-S-2a CYP11A1 STAR HYPOXIA MEDIATED EMT AND STEMNESS%WIKIPATHWAYS_20260510%WP2943%HOMO SAPIENS Hypoxia mediated EMT and stemness DICER1 NF KB SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260510%WP5527%HOMO SAPIENS NF kB signaling and ARTD family members TFPI2 BTRC CLDN6 EP300 SKP1 RBX1 RIGI IKBKB CREBBP PARP14 NFKBIA CHUK IKBKG MAP3K14 RELB MAVS GSK3B NFKB2 ZC3HAV1 TIPARP PARP16 PARP12 PARP1 PARP10 TBK1 ERN1 PARKIN UBIQUITIN PROTEASOMAL SYSTEM PATHWAY%WIKIPATHWAYS_20260510%WP2359%HOMO SAPIENS Parkin ubiquitin proteasomal system pathway PSMC1 CASP8 PARK2 STUB1 HEL-S-91n HSPA4 PSMC6 TUBAL3 TUBB8 PSMC4 TUBA3E TUBA1C SIAH1 TUBB6 TUBA1B TUBA1A TUBB1 TUBB FBXW7 TUBB4B PSMD2 TUBB4A TUBA4A TUBB2A SIAH2 TUBA2 TUBA8 UBE2L6 HEL-S-103 GPR37 UBE2G1 UBE2G2 UBE2J1 SNCAIP SEPT5 PSMD7 PSMD10 PSMD5 PSMD12 PSMD13 HEL-S-89n PSMD11 SNCA HEL-S-72p UBE2J2 PSMD9 PSMD6 CCNE1 PSMD4 PSMD3 PSMD1 CASK RNF19A HSPA2 TUBA4B HSPA14 MACROPHAGE STIMULATING PROTEIN MSP SIGNALING%WIKIPATHWAYS_20260510%WP5353%HOMO SAPIENS Macrophage stimulating protein MSP signaling RPS6KA3 SLPI CSF2 PRKAA2 RELA ACACA NR0B2 MAPK9 MAPK8 IL10 FLT1 PLCG1 MAPK3 PTEN TGFB1 IGF1R RPS6 RPS6KB1 HEL113 MAPK14 SMAD2 CPT1A KDR MST1R SOCS1 PDGFRA KLK15 MAP2K2 CCL2 CTNNB1 SOCS3 SMAD1 SMAD9 CRKL DUSP4 DKFZp781O1323 PDPK1 JUN SMAD6 SP7 SHC1 SRC PCNA RPS6KA4 HEL-S-102 TJP1 CLDN1 HK2 CDH2 CSF3 EGR1 ITGB1 MTOR FZD1 GRB2 FGFR1 IL1B WNT10B RPS6KA5 CXCL1 MAPK1 CXCL2 RAF1 HEL-S-133P CXCL5 NFKB1 MMP9 TNF PIK3R1 IL6 BGLAP IBSP RPS6KA1 COL4A1 IFNB1 GSK3B CXCL8 VEGFA PRKCB CLDN5 SIX1 ZEB2 MAP2K1 PARP1 ACTA2 SNAI2 FOS PPARGC1A 10Q22Q23 COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5402%HOMO SAPIENS 10q22q23 copy number variation SH2D4B FAM25A BUB1B ADIRF LDB3 GHITM CDHR1 DYDC2 ZMYND11 RGR GPR15LG SNCG GPR15 SUSD2 TSPAN14 RSPH1 LRIT2 GLUD1 SHLD3 LRIT1 PRXL2A SHLD2 SHLD1 RAD21 CCSER2 ACTN2 STAG1 TNFSF11 SMC1A BMP2 MAT1A ROPN1L BMPR1A NRG3 RSPH6A DNAJB13 MAD2L2 DYDC1 PPARG OPN4 RSPH14 IQUB NFKB1 NME5 CEBPA PDS5B RSPH9 PDS5A WAPAL ERBB4 SH3GL3 RSPH3 MMRN2 MGRA VEGFA SMC3 ADAM10 SIRT4 NEPHROTIC SYNDROME%WIKIPATHWAYS_20260510%WP4758%HOMO SAPIENS Nephrotic syndrome CTLA4 LAMB2 COQ6 HEL-S-47e LMNA SMARCAL1 GPC5 CYP11B2 YARS ALG1 CD151 ARHGAP24 PLCE1 ZMPSTE24 WT1 SCARB2 PTPRO APOL1 SYNPO PAX2 E2F3 COQ8B TRPC6 EMP2 LMX1B COL4A4 ACTN4 COL4A3 CD2AP INF2 COL4A5 MYH9 ITGB4 MYO1E NPHS1 NPHS2 WDR73 CUBN COQ2 STEROID BIOSYNTHESIS%WIKIPATHWAYS_20260510%WP496%HOMO SAPIENS Steroid biosynthesis HSD17B7 HSD17B3 CPN1 HSD17B2 HSD3B2 HSD17B1 HSD3B1 HSD17B4 F13B CYP17A1 MARKERS OF KIDNEY CELL LINEAGE%WIKIPATHWAYS_20260510%WP5236%HOMO SAPIENS Markers of kidney cell lineage CITED1 KDR DACT1 KCTD1 EPO PECAM1 TSHZ3 TBX18 VSX2 FGF7 TLX1 FGF8 AXIN2 EMX2 SMAD1 KIT DCN SFRP1 RSPO1 DKFZp781O1323 FOXD1 WNT4 NPHS1 TNC NPHS2 GDNF SALL1 EYA1 LHX1 FAT4 TCF2 NTN1 PBX1 HNF1A BMP4 BMP7 NT5E WT1 OSR1 TCF21 PAX2 SIX2 NOTCH2 ALDH1A2 RSPO3 NOTCH1 REN tmp_locus_29 SIX1 NR2A1 EGLN1 EGLN3 ACTA2 EGLN2 TRIACYLGLYCERIDE SYNTHESIS%WIKIPATHWAYS_20260510%WP325%HOMO SAPIENS Triacylglyceride synthesis PLPP2 PLPP1 AGPAT5 AGPAT4 MOGAT3 GPAM GPD1 MOGAT2 DGAT1 MOGAT1 LIPE AGPAT3 LIPC LPL LIPF GNPAT DGAT2 AGPS PNPLA2 PLPP3 COVID 19 THROMBOSIS AND ANTICOAGULATION%WIKIPATHWAYS_20260510%WP4927%HOMO SAPIENS COVID 19 thrombosis and anticoagulation PLG F2 HEL-S-78p F13A1 FGA F13B LAC PHE PATHWAY%WIKIPATHWAYS_20260510%WP5239%HOMO SAPIENS Lac Phe pathway CNDP2 ABCC5 EICOSANOID METABOLISM VIA CYTOCHROME P450 MONOOXYGENASES PATHWAY%WIKIPATHWAYS_20260510%WP4720%HOMO SAPIENS Eicosanoid metabolism via cytochrome P450 monooxygenases pathway CYP4F12 EPHX2 CYP4A11 CYP2C18 CYP4F2 CYP4A22 PPARG NR1C1 CYP2C8 HEPATITIS B INFECTION%WIKIPATHWAYS_20260510%WP4666%HOMO SAPIENS Hepatitis B infection CREB1 EP300 MAP2K3 TLR4 RELA JAK3 MAPK9 MAPK8 MAPK3 TGFB1 BRAF MAPK14 SMAD2 SMAD4 BCL2 TIRAP JUN PIK3CA NFATC3 PCNA NFATC4 IFNA1 MAP3K7IP1 ATF2 IF1AA9 IRAK1 IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 IFNA21 IKBKB MAP3K1 CHUK TRAF6 MAPK1 IKBKG RAF1 NFKB1 IFNA4 MAP2K6 IFNA7 MAPK13 IFNA6 IFNA2 IFNA8 CASP10 IFNAR1 IFNB1 STAT2 PRKCB MAP3K7 PRKCA TICAM2 VDAC3 APAF1 MAPK12 MAPK11 CASP8 TNFSF6 FADD CDKN1A JAK1 DDB1 STAT5B CREBBP PIK3CD STAT1 IRAK4 MYC AKT3 FAS CYCS STAT4 TYK2 HRAS TGFBR1 MAP2K2 HSPG2 MYD88 YWHAQ NFATC1 HEL-S-1 SOS1 SOS2 MAP2K4 YWHAZ SRC IFIH1 TBK1 NFATC2 IKBKE TICAM1 STAT3 IRF3 MAPK10 IRF7 TLR3 RIGI KRAS GRB2 BIRC5 ATF6B CREB3L3 CREB3L4 CREB3L2 ARAF PTK2B CREB3 MMP9 CREB5 ATF4 DDB2 PIK3R3 TNF PIK3R2 PIK3R1 TGFBR2 MAVS DDX3X NRAS EGR2 IL6 TRAF3 BAD CXCL8 BAX CASP9 CASP12 CASP3 MAP2K1 FOS DNA IR DOUBLE STRAND BREAKS AND CELLULAR RESPONSE VIA ATM%WIKIPATHWAYS_20260510%WP3959%HOMO SAPIENS DNA IR double strand breaks and cellular response via ATM YAP1 CHEK1 MRE11A NBN APAF1 BRCA2 RIF1 BRCA1 CDKN2A MDM2 ACTL6A CDK5 RAD9A PRKDC TP73 TRAF6 BLM MDC1 RASSF1 HSF1 RNF8 TERF2 FANCD2 ATR NABP2 MCPH1 SMC1A BAK1 TP53BP1 BAX H2AX CASP9 RAD52 RAD17 PCNA TRIM28 CASP3 LATS1 ATM SMC3 ATF2 PARP1 KAT5 RAD50 CHEK2 RAD51 TARGETED AGENTS IN TRIPLE NEGATIVE BREAST CANCER%WIKIPATHWAYS_20260510%WP5215%HOMO SAPIENS Targeted agents in triple negative breast cancer MTOR PARP2 KRAS GRB2 MAPK3 PTEN ARAF RPTOR RPS6KB1 DEPTOR BRAF MAPK1 RAF1 AKT3 MLST8 HRAS MAP2K2 PIK3R1 TSC2 INPP4B NRAS TSC1 AKT1S1 MAPKAP1 SOS1 RICTOR SOS2 PIK3CA IRS1 MAP2K1 PARP1 EIF4EBP1 IDO METABOLIC PATHWAY%WIKIPATHWAYS_20260510%WP5414%HOMO SAPIENS IDO metabolic pathway IFNG AADAT TNF GOT2 IDO1 TDO2 KYAT3 KYNU KYAT1 KMO IDO2 REGULATION OF CYTOTOXIC T CELL RESPONSES BY MALAT1 MIR 15 16 CIRCUIT %WIKIPATHWAYS_20260510%WP5489%HOMO SAPIENS Regulation of cytotoxic T cell responses by Malat1 miR 15 16 circuit BCL2 CD3G CD80 CD3E CD3D SPN IL2 CD27 NRXN1 DELETION SYNDROME%WIKIPATHWAYS_20260510%WP5398%HOMO SAPIENS NRXN1 deletion syndrome NLGN1 GRIN3B GRIN3A NRXN1 GRIN2B GRIN1 DLG4 GRIA3 GRIA2 NLGN3 NLGN2 GRIA4 SOLUBLE ACE2 MEDIATED CELL ENTRY OF SARS COV 2%WIKIPATHWAYS_20260510%WP5076%HOMO SAPIENS Soluble ACE2 mediated cell entry of SARS CoV 2 ACE2 AGTR1 AVPR1B ADAM17 DNA MISMATCH REPAIR%WIKIPATHWAYS_20260510%WP531%HOMO SAPIENS DNA mismatch repair POLE2 POLD2 RPA3 MSH2 PMS2 POLE RFC3 RFC4 LIG1 RFC1 POLE4 RFC2 MSH6 POLD3 POLE3 PCNA RPA1 POLD4 VITAMIN A AND CAROTENOID METABOLISM%WIKIPATHWAYS_20260510%WP716%HOMO SAPIENS Vitamin A and carotenoid metabolism BCO1 NR1B3 RARB SULT2B1 RDH8 RLBP1 RPE65 RDH12 RBP1 RDH10 RDH5 LRAT ADH1A MAPK1 HEL-S-53e CYP26A1 CYP2E1 HEL-S-4 CD36 ABCG8 ABCG5 RXRA DGAT1 SCARB1 LPL CYP26B1 ALDH1A2 RETSAT RARA DHRS3 RBP7 RBP4 RBP2 NPC1L1 SULT1A1 CRABP2 RXRB CRABP1 RXRG ALDH1A3 SDR16C5 AWAT2 NEUROGENESIS REGULATION IN THE OLFACTORY EPITHELIUM%WIKIPATHWAYS_20260510%WP5265%HOMO SAPIENS Neurogenesis regulation in the olfactory epithelium MAP2 MRE11A STAT3 RELN PAFAH1B1 AGRN TCF3 CDK5 ID1 HES1 PLXND1 NDEL1 PAX6 ID2 NTRK3 ASCL1 MYC CDK5R1 NEUROD1 BDNF DISC1 TCF4 NUMB ERBB4 RTN4 CXCL12 SOX2 VLDLR NOTCH1 APP DAB1 NGF RET GSK3B RTN4R LRP8 NRG1 NEUROG3 FAIM IL17A KDM1A GHRL PSEN1 MAP1B NTRK1 NGFR NTRK2 MEF2C APOPTOSIS MODULATION AND SIGNALING%WIKIPATHWAYS_20260510%WP1772%HOMO SAPIENS Apoptosis modulation and signaling PRKD1 DIABLO BAG3 MCL1 APAF1 BBC3 TNFSF10 BIRC7 HTRA2 BMF CASP8 BCL2L11 TNFSF6 FADD BCL2L1 BOK SMIM40 MAPK8 IL1R1 MAPK3 AIFM1 FAS CYCS BCL2 TNFRSF10B PTPN13 SEPTIN4 MYD88 TNFRSF1B JUN TNFRSF6B PTRH2 NAIP BCL2L10 TNFRSF10D IRAK1 MADD PIDD1 CDKN2A BIK BIRC5 IKBKB BIRC3 NFKBIA TRADD TRAF6 HRK CASP4 MAP3K14 BLK TNFRSF10C NFKB1 TNFRSF25 CAPNS1 CASP10 CRADD BCL2L2 TRAF3 CASP6 BIRC2 CASP2 BAK1 BCL2A1 DFFB RIPK1 BAD DFFA PMAIP1 TNFRSF10A BAX CASP9 CASP3 MAP3K5 IL1R2 TNFRSF1A AIFM2 BNIP3 FOS SUPPRESSION OF HMGB1 MEDIATED INFLAMMATION BY THBD%WIKIPATHWAYS_20260510%WP4479%HOMO SAPIENS Suppression of HMGB1 mediated inflammation by THBD IKBKB THBD NFKBIA CHUK HMGB1 RELA IKBKG AGER NFKB1 DEREGULATING CELLULAR METABOLISM THROUGH NON GENOTOXIC CARCINOGENS%WIKIPATHWAYS_20260510%WP5571%HOMO SAPIENS Deregulating cellular metabolism through non genotoxic carcinogens SESN2 EIF2A TSC2 TSC1 MTOR MARS1 LONP1 SLC7A7 CLPP IRS1 OMA1 FOXO1 HSPD1 LONP2 MYC GDF15 PHB2 ATF4 RNA POLYMERASE II TRANSCRIPTION THE PREINITIATION COMPLEX%WIKIPATHWAYS_20260510%WP5563%HOMO SAPIENS RNA polymerase II transcription the preinitiation complex POLR2B POLR2D NELFCD POLR2G POLR2I POLR2J MED9 POLR2F POLR2H POLR2K POLR2L MED23 TAF13 TAF1 TAF8 MED27 NELFA CTDP1 CDK8 TAF5 GTF2B MED19 MED16 MED18 MED17 MED12 MED11 THRA MED13 MED10 NELFB MED8 MED4 GTF2F1 MED26 MED6 MED29 MED28 MED22 MED25 MED24 MED21 GTF2A1 TAF9 GTF2E2 MED30 MED31 POLR2M TAF10 POLR2C TAF11 MED1 TBP TRFP TAF7 TAF6 CRSP9 TAF4 TAF3 MED14 MED15 TAF12 CCNC POLR2A ENDOCHONDRAL OSSIFICATION WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260510%WP4808%HOMO SAPIENS Endochondral ossification with skeletal dysplasias PLAT STAT5B TGFB1 MGP SOX6 STAT1 IGF1R GHR IGF2 FGF2 CALM1 CDKN1C RUNX3 BMP6 BMPR1A GLI3 IGF1 MEF2C THRA FGF18 IHH PTH1R PTHLH PTH FRZB PTCH1 CHST11 RUNX2 ALPL FGFR3 FGFR1 MMP9 BMP7 GH1 ACAN SPP1 COL10A1 ADAMTS4 SOX9 ADAMTS5 ENPP1 TIMP3 HMGCS1 NKX3-2 KIF3A SOX5 CAB39 CST5 VEGFA COL2A1 SCIN DDR2 PEPTIDE GPCRS%WIKIPATHWAYS_20260510%WP24%HOMO SAPIENS Peptide GPCRs EDNRA EDNRB C5AR1 AVPR2 CCR5 CXCR4 CXCR3 LHCGR AVPR1B NPY1R FPR2 MC1R GRPR TACR1 GNRHR CCR3 CCR10 CCR1 CCR8 FPR1 CCR7 CCR6 CCR4 CXCR1 CCR2 CCKBR FSHR BDKRB2 SSTR2 BDKRB1 CXCR5 CXCR6 MC3R FY AGTR1 NTSR1 AGTR2 ATP8A1 BRS3 CCKAR NPY5R OXTR TACR2 NPY2R TACR3 C3AR1 OPRM1 AVPR1A SSTR3 SSTR4 FPRL2 TRHR SSTR5 OPRD1 IL8RB NPY4R OPRK1 MC2R GALR3 GALR2 TSHR GALR1 TAC4 HCRTR2 MC4R NTSR2 HCRTR1 MC5R NMBR CX3CR1 GHSR NANOPARTICLE MEDIATED ACTIVATION OF RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP2643%HOMO SAPIENS Nanoparticle mediated activation of receptor signaling MAPK12 MAPK10 ITGB1 MAPK11 KRAS MAPK9 GRB2 MAPK8 ITGA1 PIK3CD MAPK1 MAPK14 RAF1 AKT3 MAPK13 HRAS TLN1 MAP2K2 NRAS AREG SOS1 PXN COL1A1 SRC EGFR MAP2K1 CAFFEINE IN NEURONS%WIKIPATHWAYS_20260510%WP5602%HOMO SAPIENS Caffeine in neurons ADORA2A ADRA1D ADRA1B ADRA1A MINERALOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260510%WP5279%HOMO SAPIENS Mineralocorticoid biosynthesis HSD11B1 AKR1C4 UGT2B7 HSD11B2 CYP21A2 SRD5A2 AKR1C1 UGT1A10 CYP11B2 AKR1C2 AKR1D1 ZINC HOMEOSTASIS%WIKIPATHWAYS_20260510%WP3529%HOMO SAPIENS Zinc homeostasis MT1A MTF1 MT1F MT1G SLC39A9 MT1B SLC39A6 SLC39A5 SLC39A8 MT1E SLC39A2 SLC39A1 SLC39A3 SLC39A11 SLC39A10 MT2A SLC39A13 SLC39A12 MT1M SLC39A14 SLC30A10 SLC30A7 SLC30A6 SLC30A9 SLC30A8 SLC30A2 SLC30A5 SLC30A4 MT4 SLC30A1 MT3 UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260510%WP4925%HOMO SAPIENS Unfolded protein response BCL2 PPP1R15A TNFRSF10B BBC3 TXNIP BCL2L11 MBTPS1 CASP2 EIF2S1 PMAIP1 IL1B MBTPS2 HEL-S-89n NFE2L2 DDIT3 XBP1 RTCB ATF4 ERN1 PRO SURVIVAL SIGNALING OF NEUROPROTECTIN D1%WIKIPATHWAYS_20260510%WP5182%HOMO SAPIENS Pro survival signaling of neuroprotectin D1 TNF TRAF2 CASP8 FADD RIPK1 RIPK3 BAX CASP9 BIRC3 TRADD CASP3 TNFRSF1A CYCS NCRNAS IN WNT SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260510%WP4336%HOMO SAPIENS ncRNAs in Wnt signaling in hepatocellular carcinoma CSNK1A1L SOX17 CER1 CSNK2A3 CSNK2A2 CTNNBIP1 DKK2 SFRP5 MTDH SOX7 CSNK2B PORCN CHD8 SOST KREMEN1 SENP2 CCND1 CXXC4 MYC NKD1 NKD2 WIF1 FOSL1 NOTUM CTNNB1 DKK1 CTBP1 SFRP1 NLK FRAT1 DVL1 DVL2 JUN DVL3 WNT4 TCF7L2 LEF1 RYK AXIN1 LRP5 CSNK1E ROR1 CTBP2 ROR2 LRP6 WNT1 CSNK1A1 TCF7L1 WNT2B CSNK2A1 FZD10 ELAVL1 APC WNT5B WNT16 FZD1 SFRP4 KLF4 EZH2 WNT3 WNT10B WNT10A FRAT2 FZD3 FZD2 FZD5 WNT3A WNT7B FZD7 DKK4 FZD9 WNT7A FZD8 GSK3B CCND3 CCND2 BONE MORPHOGENIC PROTEIN SIGNALING AND REGULATION%WIKIPATHWAYS_20260510%WP1425%HOMO SAPIENS Bone morphogenic protein signaling and regulation SMAD6 SMURF1 BMPR1A BMPR2 TOB1 SMAD1 NOG SMAD4 BMP2 TOB2 RUNX2 ALA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260510%WP5136%HOMO SAPIENS ALA oxylipin metabolism ALOX5 EPHX2 ALOX15 SODIUM CHANNEL IN EPILEPSY%WIKIPATHWAYS_20260510%WP5598%HOMO SAPIENS Sodium channel in epilepsy PDCD10 SCN7A FGF14 MAPK8IP2 SCNM1 FGF13 FYN SCN4A FGF12 RNF121 SCN3B SCN5A SCN3A SCN1A PRRT2 SCN2B SCN8A SCN2A SCN1B SCN4B CALM1 TNF NEDD4 SCN9A SCN10A GSK3B PSEN1 CAMK2A BACE1 PTPRN SCN11A WEE1 AFFECTED PATHWAYS IN DUCHENNE MUSCULAR DYSTROPHY%WIKIPATHWAYS_20260510%WP5356%HOMO SAPIENS Affected pathways in Duchenne muscular dystrophy TNNI1 ITPR2 PRKAA2 MCUB SCX TOMM20 TRDN ATP2A1 DAG1 CACNA1S IL10 IL1A TGFB1 CYBB TRPC1 SSPN SNTB1 SMAD2 SMAD4 TGFBR1 RYR1 CACNA1F CACNG1 TRPC6 MPO SLN CASQ1 CAMK2D CACNA2D1 FGA SLC25A5 CAPN3 HEL-S-78p ELANE PLA2G2A NOS2 STIM1 IL1B NFKBIA FKBP1A AGTR1 MMP2 NFKB1 MMP9 PRG3 PPIF TNF TGFBR2 CTGF IL6 SGCA SPP1 TRPC3 PRKAA1 DMD CASP9 SIGMAR1 MCU CACNB1 ORAI1 NOX4 IL3 SIGNALING%WIKIPATHWAYS_20260510%WP286%HOMO SAPIENS IL3 signaling INPP5D STAT3 FYN GAB2 PTPN6 BCL2L1 GRB2 IL5RA MAPK8 CSF2RB MAPK3 JAK1 RAPGEF1 LYN STAT5B TGFB1 PIK3CD SYK VAV1 MAPK1 RAF1 HRAS BCL2 PIK3R2 PIK3R1 IL3 IL3RA CD69 YWHAQ BAD CRKL HEL-S-1 ENPP3 PTPN11 SOS1 CXCL8 JUN SHC1 SRC MAP2K1 CBL FOS CCR3 FACT COMPLEX AND DNA DOUBLE STRAND BREAK REPAIR%WIKIPATHWAYS_20260510%WP5564%HOMO SAPIENS FACT complex and DNA double strand break repair NBN H1-1 TP53BP1 PRKDC XRCC5 ATM H4C9 RNF168 MDC1 SUPT16H HIST1H4L SSRP1 SETD2 RNF8 NASP RAD51 NON GENOMIC ACTIONS OF 1 25 DIHYDROXYVITAMIN D3%WIKIPATHWAYS_20260510%WP4341%HOMO SAPIENS Non genomic actions of 1 25 dihydroxyvitamin D3 TLR4 MAPK12 MAPK11 PRKCZ IFI27L2 MAPK9 RSAD2 MAPK8 PLCG2 PLCB1 JAK1 MAPK3 STAT1 CD40LG MAPK14 CAMP DEFB4B IFNGR1 PLCE1 TYK2 HRAS SP1 IFNG CCL2 PLCB4 RXRA JUN PLCB3 CAMK2D CAMK2A OAS2 IFI44L KRAS CYP27B1 CAMK2G CYP24A1 IKBKB MAPK7 MED1 MAPK1 PLCB2 NFKB1 MAPK13 IFNA2 NR1i1 IFNAR2 TNF RELB NRAS IL6 CD40 STAT2 CXCL8 PRKCH PRKCB NFKB2 PRKCE PRKCA TLR8 IFNGR2 TNFRSF1A RXRB RXRG SP3 NOD2 ISG15 PRKCQ CLOCK CONTROLLED AUTOPHAGY IN BONE METABOLISM%WIKIPATHWAYS_20260510%WP5205%HOMO SAPIENS Clock controlled autophagy in bone metabolism CTSK CTHRC1 CSF1 PRKAA2 SEMA3A ARHGAP4 FYCO1 DRAM2 VCP SEMA4D TGFB1 ULK1 LAMP2 SOST DKFZp762B153 SMAD4 MAP1LC3A AMBRA1 ATG5 ATG3 TNFRSF11B ATG101 ATG10 TNFRSF11A BCL2 TNFSF11 CRY1 IL3 ATG12 SMAD1 SMAD9 ATG16L1 DKK1 NFATC1 BMP6 BMP2 PLEKHM1 DKFZp781O1323 PER1 RB1CC1 SP7 EFNB2 LRP5 BMPR2 IGF1 RORB MTOR HMGB1 PTH WNT16 BHLHB2 RUNX2 BMP4 SQSTM1 BHLHE41 WNT10B CTF1 TRAF6 LEP BMP3 NPAS2 IL6 NOTCH1 CALCA BMP5 NR1D2 7 OXO C AND 7 BETA HC PATHWAYS%WIKIPATHWAYS_20260510%WP5064%HOMO SAPIENS 7 oxo C and 7 beta HC pathways HSD11B1 CYP7A1 HSD11B2 DHCR7 NPC1 DBP NPC2 THEM5 ACOT9 ACOT8 ACOT7 ACOT11 ACOT12 ACOT13 BAAT EBP ACOT6 CYP27A1 ACOT4 EPHX2 AMACR SLC27A5 SLC27A2 EXERCISE AND HYPERTROPHY IN SKELETAL MUSCLE%WIKIPATHWAYS_20260510%WP516%HOMO SAPIENS Exercise and hypertrophy in skeletal muscle IFNG ANKRD1 CYR61 ATF3 GDF8 MYOG IL1R1 DUSP14 IL1A EIF4E HEL-S-52 VEGFA JUND ADAM10 HBEGF IFRD1 IL18 EIF4EBP1 NR4A3 NPHP1 DELETION SYNDROME%WIKIPATHWAYS_20260510%WP5399%HOMO SAPIENS NPHP1 deletion syndrome FLNB MAPK3 NPHP1 INVS RPGRIP1L PTK2B MAPK1 FLNA N GLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260510%WP5153%HOMO SAPIENS N glycan biosynthesis RFT1 DPAGT1 GMPPB MAN1A2 MAN1A1 ALG8 ST6GAL1 ALG9 ST6GAL2 ALG5 ALG1 ALG2 ALG14 ALG13 ALG3 ALG12 ALG11 ALG10 DDOST DPM3 GCS1 MAN1B1 ALG10B FUT8 GANAB TUSC3 MAN2A2 MAN2A1 DPM2 MGAT5 MGAT5B MGAT3 MGAT2 SRD5A3 DOLK MGAT4C MGAT4D MGAT4A DOLPP1 MGAT4B MGAT1 STT3A STT3B B4GALT2 ALG6 RPN2 RPN1 DPM1 B4GALT1 MPDU1 PROTEOGLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260510%WP4784%HOMO SAPIENS Proteoglycan biosynthesis CHST3 XYLT1 PAPSS2 EXT1 XYLT2 CHST14 EXT2 CHSY1 CSGALNACT1 SLC35B2 B3GAT3 CANT1 BPNT2 SLC26A2 B3GALT6 PRADER WILLI AND ANGELMAN SYNDROME%WIKIPATHWAYS_20260510%WP3998%HOMO SAPIENS Prader Willi and Angelman syndrome NIPA1 LHB TUBGCP6 TUBGCP4 NIPA2 NUP107 ATP10A FMR1 PRKCZ GNRH1 AHCTF1 DLX5 CCND1 SNURF POMC RNF8 CDC6 HERC2 NUP62 MSX1 TYR RB1 NUP85 NUP188 NPAP1 NUP214 CDKN2B NDC1 CDKN2C GOLGA8S PCSK1 NUP210 GOLGA6L2 NUP93 FEZ1 FEZ2 NUP54 NUP58 OCA2 NUP205 SLC45A2 CDKN2A SEH1L MDM2 AAAS HEL-S-71 BBS4 NUP160 MAGEL2 NHLH2 TPR NUP42 RANBP2 CDK6 NUP155 NUP153 CDK4 NUP35 MKRN3 NUP88 GABRG3 GABRG2 GABRG1 NDN TACR3 OXT POM121 BDNF GABRB3 SNRPN FSHB NUP98 PCM1 CGA RAE1 NGF GABRR3 KISS1 MDM4 GABRR1 EIF4E GHRH UBE3A GHRL NUP133 GABRA5 CCND2 INS CYFIP1 TUBGCP5 VITAMINS A AND D ACTION MECHANISMS%WIKIPATHWAYS_20260510%WP4342%HOMO SAPIENS Vitamins A and D action mechanisms RXRA RARA NR1i1 INHIBITORS OF METABOLISM IN MELANOMA THERAPY%WIKIPATHWAYS_20260510%WP5609%HOMO SAPIENS Inhibitors of metabolism in melanoma therapy RPS6KA3 PKLR DLAT MTOR GLS SLC16A3 MAPK3 LDHB HEL-S-304 ARAF PFKFB2 RPTOR DLD BRAF HEL-S-30 MAPK1 CPT1A HEL-S-133P RAF1 MLST8 MAP2K2 GPX4 RPS6KA2 RPS6KA1 NAMPT ACSS1 HEL-75 PDHA1 MAP2K1 PPARGC1A HIJACK OF UBIQUITINATION BY SARS COV 2%WIKIPATHWAYS_20260510%WP4860%HOMO SAPIENS Hijack of ubiquitination by SARS CoV 2 CBFB UBA3 ELOC RBX1 NAE1 STEROL REGULATORY ELEMENT BINDING PROTEINS SREBP SIGNALING%WIKIPATHWAYS_20260510%WP1982%HOMO SAPIENS Sterol regulatory element binding proteins SREBP signaling CREB1 PRKAA2 ACACA GSK3A SEC23A LPIN1 CAMP DBI SP1 SCARB1 INSIG1 LPL MBTPS1 LDLR RBP4 SAR1B PIK3CA CDK8 MBTPS2 SCD FASN FGF21 HEL-S-32 SQLE ACLY MTOR PPARG SAR1A RNF139 PRKAB2 SEC23B SEC31B PRKAB1 SEC31A AMFR NFYA SEC24C YY1 MED15 PPARGC1B GPAM SIRT1 PRKAG1 PRKAG2 PRKAG3 PRKAA1 ACSS1 HMGCS1 SREBF2 HMGCR IDI1 FDPS INS MVD NR1H2 FDFT1 CYP51A1 GLUCOCORTICOID RECEPTOR PATHWAY%WIKIPATHWAYS_20260510%WP2880%HOMO SAPIENS Glucocorticoid receptor pathway DNAJC15 ARL5B SRGN NAV3 ADGRF4 PRRG4 PPP1R14C SLC19A2 S100P NR3C1 ALOX5AP IL11 STOM PTGES3 CCL2 THBD ANKRD1 CDKN1C RXRA TNFAIP3 ACKR3 JUN POU5F1 DNER ZIC2 TNS4 TGFBR3 FGFBP1 BHLHB2 BIRC3 SPRY1 PDE4B CCL20 AMIGO2 MGAM RGS2 B3GNT5 ANGPTL4 BIRC2 GADD45B PTGS2 PLK2 CPEB4 EPB41L4B ENC1 EDN2 TSC22D3 CDC42EP3 NFKB2 PMP2 MFGE8 FGD4 GPR153 SERTAD2 CAVIN2 KTN1 NR1i2 SCNN1A SLC26A2 NR1I3 SNAI2 ABHD2 LEPTIN SIGNALING%WIKIPATHWAYS_20260510%WP2034%HOMO SAPIENS Leptin signaling CREB1 SOCS2 PRKAA2 RELA ACACA GSK3A MAPK8 PLCG2 CISH PLCG1 JAK1 MAPK3 PTEN STAT5B STAT1 RPS6 NCOA1 RPS6KB1 KHDRBS1 ACACB MAPK14 ARHA HRAS SP1 MAP2K2 CFL2 SOCS3 SOS1 SHC1 SRC FOXO1 EIF4EBP1 PTPN1 STAT3 FYN MTOR REL GRB2 IKBKB CHUK SH2B1 MAPK1 IKBKG RAC1 RAF1 ROCK1 ROCK2 KPNA4 NFKB1 LEP CDC42 PIK3R2 PIK3R1 RPS6KA1 PRKAA1 BAD PTPN11 GSK3B EIF4E SOCS7 PDE3B IRS1 MAP2K1 LEPR ERBB2 KETOGENESIS AND KETOLYSIS%WIKIPATHWAYS_20260510%WP4742%HOMO SAPIENS Ketogenesis and ketolysis BDH1 OXCT1 CPT2 UCP2 SLC25A20 ACAT1 16P11 2 PROXIMAL DELETION SYNDROME%WIKIPATHWAYS_20260510%WP4949%HOMO SAPIENS 16p11 2 proximal deletion syndrome PAGR1 MAP2K3 CASP8 NR3C1 CDIPT HDAC3 MAPK3 PTEN PPP2R1A UNC13A PPP2R5D BPTF PPP2CA SIAH1 SPN HEL70 TBX6 SMEK1 EZR PARP4 PPP4R3B PCNA CCT7 TAOK2 REL KMT2C PPARG CCT6B MLL2 TRAF6 HEL-S-87p PRRT2 NFKB1 DOC2A MAP2K6 FAM57B FIMP PPP4R1 PPP4R2 PPP4R4 CCDC6 HEL-S-69 TRAF2 ASPHD1 TCP1 HEL-S-90n KCTD13 ZG16 PAXIP1 INO80E MVP HIRA GDPD3 CORO1A HIRIP3 PPP4C CCT8 CCT4 IGBP1 HEL-S-100n C16orf54 CCT6A YPEL3 UNC13B TAMOXIFEN METABOLISM%WIKIPATHWAYS_20260510%WP691%HOMO SAPIENS Tamoxifen metabolism UGT2B7 UGT2B15 UGT1A10 SULT1E1 UGT1A8 CYP3A4 CYP2C19 CYP1B1 CYP2C9 CYP2C8 UGT1A4 CYP1A2 SULT1A1 CYP2A6 SULT2A1 CYP1A1 CYP2E1 ANGIOGENESIS OVERVIEW%WIKIPATHWAYS_20260510%WP1993%HOMO SAPIENS Angiogenesis overview NRP1 SEMA3A MAPK11 MAPK8 ROBO4 DAG1 PLCG1 PIK3CD MAPK14 KDR ANGPT1 SOS1 PLA2G1B NCK1 MAP2K4 PDPK1 PXN IQGAP1 SHC1 SRC SHB CRK ROBO1 ATF2 MTOR SLIT2 APC KRAS GRB2 PLXND1 FGFR1 MMP14 F2 PTK2B MAPK1 RAC1 RAF1 MMP2 WAS MMP9 MAP2K6 BMX CDC42 TIMP4 PAK1 FRS2 VHL BAD GRB14 PTPN11 VEGFA MAP3K7 PRKCA MAP2K1 NOX4 GRB7 HIF1A AND PPARG IN HYPERTROPHIC CARDIOMYOPATHY%WIKIPATHWAYS_20260510%WP2456%HOMO SAPIENS HIF1A and PPARG in hypertrophic cardiomyopathy HEL-S-49 GPD1 HMFN0839 HIF1A HEL-S-133P PPARG CD36 HEL-S-162eP MESODERMAL COMMITMENT PATHWAY%WIKIPATHWAYS_20260510%WP2857%HOMO SAPIENS Mesodermal commitment pathway NR1B3 YAP1 RARB ACACA ZFHX4 SCHIP1 HAND1 PAX6 SMAD2 SMAD4 TOX3 PPP2CA FGF8 TCF4 TET1 HES7 SMAD1 TBX6 DKK1 ARID5B BCORL1 LEFTY2 BMPR1A FOXC1 BMPR2 CTBP2 DNMT3B AMH ACVR1 ZIC2 ACVR2B KLF4 WNT3 FZD5 FZD4 WNT3A TOX FZD8 AEBP2 CSRP2 CCDC6 MIXL1 SLC2A12 HMGA2 ADAM19 FOXC2 TWSG1 MSGN1 ARL4A WDCP SETD2 PIAS1 PRKAR1A FOXA1 NODAL SOX17 SOX21 CEP250 WDHD1 VAV3 EMSY PBX3 ATP8B2 CUL4B WDFY2 CCND1 MBTD1 PLCH1 EPB41L5 UBR5 GDF3 LEFTY1 TRERF1 PITX2 NABP2 AXIN2 ACVR2A GATA3 TRIM71 SOX2 PHF6 NOG FOXH1 ZIC3 NLK TRIM5 PARP8 EXT1 SMAD6 AHDC1 EXT2 POU5F1 LEF1 AXIN1 ZNF462 ELP4 ZIC5 HPRT1 RPL38 C9orf72 CRTC1 TCF7L1 PBX1 TBX3 TEAD2 BHLHB2 INHBA JARID2 BMP4 FOXA2 FGFR1 C1QBP SNAI1 RGS10 BMP7 SESN1 MEIS1 KLF5 HTT TRIM28 NFE2L2 LATS1 NR2A1 GATA6 TBX1 REGULATION OF SISTER CHROMATID SEPARATION AT THE METAPHASE ANAPHASE TRANSITION%WIKIPATHWAYS_20260510%WP4240%HOMO SAPIENS Regulation of sister chromatid separation at the metaphase anaphase transition BUB1B APC SMC1A RAD21 SMC3 CDC20 MAD1L1 MAD2L1 CENPE ESPL1 PTTG1 STAG1 CHOLESTASIS%WIKIPATHWAYS_20260510%WP5238%HOMO SAPIENS Cholestasis ABCG8 ABCG5 RXRA SCARB1 ABCC3 ABCC2 LDLR ABCB4 SLCO1A2 HMGCR ABCB11 ATP8B1 EPHX1 NR1H4 SLC22A1 NR1I3 PHOSPHOINOSITIDE 3 KINASE PI3K FAMILY%WIKIPATHWAYS_20260510%WP5472%HOMO SAPIENS Phosphoinositide 3 kinase PI3K family PIK3CA PIK3R3 PIK3R2 PIK3CD PIK3R1 PIK3R4 PIK3C2G PIK3C2A PIK3C2B PIK3R5 KILLER CELL IMMUNOGLOBULIN LIKE RECEPTORS AND HUMAN LEUKOCYTE ANTIGEN C PATHWAY%WIKIPATHWAYS_20260510%WP5576%HOMO SAPIENS Killer cell immunoglobulin like receptors and human leukocyte antigen C pathway IFNG TNF CSF2 FYN PTPN6 CD34 HLA-C GRB2 PLCG1 LCP2 SYK LAT PRKCA VAV1 KIR2DL1 KIR2DL3 TYROBP RAC1 HRAS PRKCQ CCL18 SIGNALING%WIKIPATHWAYS_20260510%WP5097%HOMO SAPIENS CCL18 signaling CDH2 PTK2B CCR8 ZEB2 MMP2 AK4 PCSK9 MEDIATED LDL RECEPTOR DEGRADATION%WIKIPATHWAYS_20260510%WP2846%HOMO SAPIENS PCSK9 mediated LDL receptor degradation PCSK9 LDLR MITOCHONDRIAL CARRIER DEFICIENCY ASSOCIATED WITH SHUTTLE DISTURBANCES%WIKIPATHWAYS_20260510%WP5507%HOMO SAPIENS Mitochondrial carrier deficiency associated with shuttle disturbances GLUD1 SLC25A12 SLC25A22 GOT2 SLC25A13 10Q11 21Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP5352%HOMO SAPIENS 10q11 21q11 23 copy number variation syndrome RGMB BAZ1B ChAT WDFY4 PARG LRRC18 ARHGAP22 HSF4 DRGX SLC18A3 KDM4D C10orf53 SMARCA5 EIF4ENIF1 DEK MAPK8 TMEM273 UVSSA GDF5 CUL5 JUND ERCC5 DLD HSF1 BCL2 SMAD1 NOG SMAD9 MYBBP1A BMP2 DKFZp781O1323 MEN1 PCNA BMPR1A ITCH SF3B1 ELOA ATF2 SMARCC2 RIF1 DDX21 SIRT6 SIRT1 NEO1 NLRP3 MYO1C OGDHL FAM170B CEFIP VSTM4 TRANS SULFURATION ONE CARBON METABOLISM AND RELATED PATHWAYS%WIKIPATHWAYS_20260510%WP2525%HOMO SAPIENS Trans sulfuration one carbon metabolism and related pathways HEL-S-75p PCYT1B CHKB AHCYL1 PCYT2 SHMT1 CHKA SLC25A48 ETNK1 BHMT2 AMT pcap CEPT1 GPX7 ALDH7A1 MTHFD2L HEL-S-182mP GAD1 GAD2 HEL-S-44 PEMT DNMT3L BCAT1 BCAT2 AHCYL2 HEL-S-61p BAAT MAT1A MTHFD1L MTHFD1 MTHFD2 CHDH DNMT3B CBS MTR CDO1 PSAT1 PHGDH HEL-S-51e AGXT2 PSPH TYMS DHFR GPX4 GPX2 GPX1 GPX3 GPX6 HEL-S-64p HEL-75 GCLC CTH GCLM DEGRADATION PATHWAY OF SPHINGOLIPIDS INCLUDING DISEASES%WIKIPATHWAYS_20260510%WP4153%HOMO SAPIENS Degradation pathway of sphingolipids including diseases NEU4 HEXB HEXA SCARB2 NPC1 GLA NPC2 NEU2 GM2A PSAP NEU1 LIPA NEU3 GLB1 ESTROGEN METABOLISM%WIKIPATHWAYS_20260510%WP697%HOMO SAPIENS Estrogen metabolism UGT2B7 SULT1E1 UGT1A9 CYP3A4 CYP1B1 CYP1A2 UGT1A3 GSTM1 NQO1 ARSL SULT1A1 UGT1A1 STS CYP1A1 NUCLEOTIDE EXCISION REPAIR IN XERODERMA PIGMENTOSUM %WIKIPATHWAYS_20260510%WP5114%HOMO SAPIENS Nucleotide excision repair in xeroderma pigmentosum POLD2 GPS1 H3F3B CETN2 XPA BRCA1 RBX1 XPC POLE GTF2H2C_2 RFC3 RFC4 LIG1 RFC1 POLE4 RFC2 GTF2H2 UVSSA GTF2H3 GTF2H5 CUL4A POLD3 H2AC6 DDB1 ERCC1 POLE3 ERCC2 SLX4 MNAT1 CUL4B H4C9 SLX4IP HIST1H4L POLK RPA1 DDB2 CDK7 POLE2 CHD1L RPA3 HMGN1 RAD18 XAB2 PCNA CCNH PARP1 POLD4 PATHOGENESIS OF SARS COV 2 MEDIATED BY NSP9 NSP10 COMPLEX%WIKIPATHWAYS_20260510%WP4884%HOMO SAPIENS Pathogenesis of SARS CoV 2 mediated by nsp9 nsp10 complex CD8B1 ZAP70 CD8A LCK FYN IL6 MMP25 LBP NRF IGLL1 CRP CXCL8 CD3G HLA-DRB5 CD3E CD2 HLA-DRA HLA-DRB1 PRG3 ALTERNATIVE PATHWAY OF FETAL ANDROGEN SYNTHESIS%WIKIPATHWAYS_20260510%WP4524%HOMO SAPIENS Alternative pathway of fetal androgen synthesis AKR1C4 POR HSD17B3 SRD5A2 HSD3B2 HSD17B6 AKR1C2 CYP11A1 STAR CYP17A1 SEROTONIN TRANSPORTER ACTIVITY%WIKIPATHWAYS_20260510%WP1455%HOMO SAPIENS Serotonin transporter activity TPH2 IL1B TGFB1I1 MAOA ITGB3 IL1R1 STX1A VITAMIN A1 AND A5 X PATHWAYS%WIKIPATHWAYS_20260510%WP5397%HOMO SAPIENS Vitamin A1 and A5 X pathways NR1B3 RARB RXRA RXRB RXRG RARA FOLATE ALCOHOL AND CANCER PATHWAY HYPOTHESES%WIKIPATHWAYS_20260510%WP1589%HOMO SAPIENS Folate alcohol and cancer pathway hypotheses CREB1 CBS CEBPB MTR HEL-S-53e CYP2E1 ADH5 COVID 19 AND ENDOTHELIAL CELL SENESCENCE%WIKIPATHWAYS_20260510%WP5256%HOMO SAPIENS COVID 19 and endothelial cell senescence TLR4 IL17A IL17RA IL17RC SARS COV 2 REPLICATION ORGANELLE FORMATION%WIKIPATHWAYS_20260510%WP5156%HOMO SAPIENS SARS CoV 2 replication organelle formation PIK3R4 ACTIVATION OF NLRP3 INFLAMMASOME BY SARS COV 2%WIKIPATHWAYS_20260510%WP4876%HOMO SAPIENS Activation of NLRP3 inflammasome by SARS CoV 2 IL1B PYCARD TRAF3 RELA NLRP3 NFKB1 ROLES OF CERAMIDES IN DEVELOPMENT OF INSULIN RESISTANCE%WIKIPATHWAYS_20260510%WP5181%HOMO SAPIENS Roles of ceramides in development of insulin resistance INSR PPP2CA SLC2A4 TNF PIK3R1 PRKCZ PDX1 PRKAG3 MAPK8 ACSL1 MAFA TRAF1 RPS6KB1 IRS1 TNFRSF1A EIF2AK2 INS CD36 ERN1 AUTOPHAGY%WIKIPATHWAYS_20260510%WP4923%HOMO SAPIENS Autophagy MTOR PRKAA2 ATG9A ULK1 DKFZp762B153 RPTOR PRKAB2 DEPTOR PRKAB1 AMBRA1 MLST8 ATG5 ATG101 ATG3 UVRAG WIPI2 ATG14 ATG12 PRKAG1 PRKAG2 ATG16L1 AKT1S1 PRKAA1 PRKAG3 RB1CC1 PIK3R4 ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20260510%WP528%HOMO SAPIENS Acetylcholine synthesis ACHE ChAT PEMT PDHA2 PDHA1 CHKA SULFATASE AND AROMATASE PATHWAY%WIKIPATHWAYS_20260510%WP5368%HOMO SAPIENS Sulfatase and aromatase pathway HSD17B3 HSD17B2 SULT1E1 SLCO1B1 NR3A2 HSD17B1 HSD3B1 SLCO2B1 SLCO4C1 SLCO4A1 SLCO1A2 RANKL RANK SIGNALING%WIKIPATHWAYS_20260510%WP2018%HOMO SAPIENS RANKL RANK signaling MTOR GAB2 RELA PAPSS2 MAPK9 MAPK8 PLCG1 MAPK3 SPI1 LYN TRAF1 SQSTM1 IKBKB SYK NFKBIA STAT1 CHUK TRAF6 MAPK1 MAPK14 IKBKG RAC1 NFKB1 MAP2K6 TNFRSF11B CDC42 TNFRSF11A PIK3R2 PIK3R1 TRAF2 RELB TNFSF11 TRAF5 TRAF3 NFATC1 JUN NFKB2 SRC MAP3K7 FHL2 MAP3K7IP1 MAP2K1 CBL FOS 8Q11 23 RB1CC1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5412%HOMO SAPIENS 8q11 23 RB1CC1 copy number variation TNF TRAF2 ATG16L1 GABARAPL2 GABARAPL1 RB1CC1 PTK2B ULK1 GABARAP RB1 MAP3K5 WDR45B ATG101 VITAMIN D METABOLISM%WIKIPATHWAYS_20260510%WP1531%HOMO SAPIENS Vitamin D metabolism DHCR7 CYP27A1 RXRA RXRB PTH CYP27B1 CYP2R1 CYP24A1 GC NR1i1 DICLOFENAC METABOLIC PATHWAY%WIKIPATHWAYS_20260510%WP2491%HOMO SAPIENS Diclofenac metabolic pathway CYP2C18 CYP2B6 CYP2C19 CYP2C9 CYP2C8 LET 7 INHIBITION OF ES CELL REPROGRAMMING%WIKIPATHWAYS_20260510%WP3299%HOMO SAPIENS let 7 inhibition of ES cell reprogramming KLF4 EGR1 POU5F1 TRIM71 SOX2 MYC SARS COV 2 ALTERING ANGIOGENESIS VIA NRP1%WIKIPATHWAYS_20260510%WP5065%HOMO SAPIENS SARS CoV 2 altering angiogenesis via NRP1 FURIN VEGFA ACE2 NRP1 KDR HYPOTHESIZED PATHWAYS IN PATHOGENESIS OF CARDIOVASCULAR DISEASE%WIKIPATHWAYS_20260510%WP3668%HOMO SAPIENS Hypothesized pathways in pathogenesis of cardiovascular disease LTBP2 ANGPT2 TGFBR2 CTGF TGFBR3 MAPK8 ENG LTBP1 RUNX2 MAPK3 SHC1 POSTN MAPK14 MAPK1 SMAD2 NR2C2 AGTR1 SMAD4 FBN1 FLNA FBN2 FBN3 TGFBR1 PTF1A RELATED REGULATORY PATHWAY%WIKIPATHWAYS_20260510%WP4147%HOMO SAPIENS PTF1A related regulatory pathway HES1 RBPJL CTNNB1 PTF1A NKX6-1 FGF10 PDX1 RBPJ NOTCH1 PROX1 KAT2B MALE INFERTILITY%WIKIPATHWAYS_20260510%WP4673%HOMO SAPIENS Male infertility PEX10 EP300 BRCA2 DND1 CDK9 H3-4 SHMT1 FAT10 MSH4 NQO1 AHRR STRA8 BCL2 DAZL XRCC5 HEL-S-61p FOLH1 MTHFD1 XRCC3 POLG UBE2B CYP17A1 H4C9 CLU TRIP13 REC8 CYP26B1 AGO2 TMEM132E PMS2 XPC TNFSF6 RFC1 GNAO1 CREBBP ERCC1 ERCC2 AHR NR3A2 HLA-DRA HEL110 FAS CCNK PRDM9 SIRPG EPSTI1 RAG1 PEMT NANOS1 PRM2 PRM3 ABCB1 SPATA17 TSSK4 DDX4 DAZ4 DAZ3 VCX DAZ2 MOV10L1 H2BW1 TAS2R38 PUM2 APOB PIWIL2 PIWIL1 PIWIL4 SPO11 ETV5 HORMAD2 SLC46A1 MSMB PRMT6 PACRG MTRR TEX15 PON2 TCN2 PON1 INSR CXXC1 ABLIM1 SIRPA MTR OR2W3 MAS1L SLC16A7 P1 USP26 HMGA1 CDC42BPA MLH3 MDM2 CTCFL PSAT1 NOS2 SEMG1 BRDT SRD5A2 CHD2 THBS1 CYP1A1 MMP2 MMP9 TNF GPX1 KDM3A SOX5 NFE2L2 ATM PARP1 NOTCH SIGNALING%WIKIPATHWAYS_20260510%WP268%HOMO SAPIENS Notch signaling HES5 NOTCH3 DTX2 DTX3 JAG2 KCNJ5 MFNG DLL3 HES1 DLL4 DTX3L CREBBP KAT2A PSEN2 MAML1 RBPJL NUMB LFNG NOTCH2 NOTCH1 CTBP1 DVL1 DTX1 DVL2 APH1B DVL3 NCOR2 DTX4 HDAC2 HDAC1 CTBP2 PSEN1 RBPJ ADAM17 MAML3 KAT2B REGULATION OF TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP1449%HOMO SAPIENS Regulation of toll like receptor signaling MAP2K3 TLR4 RELA MAPK9 MAPK8 SFTPA2 IL12B MAP3K8 CISH MAPK3 IL12A MAPK14 PLK1 SOCS1 TNFAIP3 LBP TIRAP JUN PIK3CA CD14 IFNA1 IRAK2 IRAK3 MAP3K7IP1 IF1AA9 TLR1 IRAK1 IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 IFNA21 RBCK1 IKBKB NFKBIA CXCL9 CHUK TRAF6 MAPK1 IKBKG NFKB1 IFNA4 MAP2K6 IFNA7 MAPK13 IFNA6 IFNA2 IFNA8 IFNAR2 MBL2 IFNAR1 SPP1 RIPK1 IFNB1 CD40 MAP3K7 TLR8 CD80 TICAM2 PIK3R5 MAPK12 MAPK11 CASP8 FADD ZMYND11 TREM1 RNF41 PIK3CD SYK STAT1 BTK IRAK4 AKT3 TIFA MLST8 CCL5 LY96 CCL4 CCL3 MAP2K2 CXCL11 MYD88 MAP2K4 SMAD6 TLR5 TBK1 TLR9 IKBKE TICAM1 IRF3 MAPK10 IRF7 TLR7 PTPN6 TLR3 PELI1 FBXW5 TAB3 CD180 TRAFD1 SQSTM1 SIGIRR IL1B CUEDC2 TMED7 SFTPD RNF31 PELI3 SARM1 RAC1 PIK3R3 TNF PIK3R2 OTUD5 PIK3R1 IL6 TRAF3 CYLD CXCL8 NFKB2 MAP2K1 FOS 7Q11 23 DISTAL COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5401%HOMO SAPIENS 7q11 23 distal copy number variation POR MDH2 EPB41L3 ZP2 SFN ZP3 YWHAG LMNA TMEM120B SRRM3 HEL-S-102 TMEM120A RAF1 SSC4D DAPK2 STYXL1 RHBDD2 HEL163 PTPMT1 KIF1C MODULATORS OF TCR SIGNALING AND T CELL ACTIVATION%WIKIPATHWAYS_20260510%WP5072%HOMO SAPIENS Modulators of TCR signaling and T cell activation ZAP70 RELA GRAP2 MAP3K8 PLCG1 LCP2 CARD11 CUL5 RNF7 CD3G BCL10 CD3E CD3D NDUFB10 SOCS1 DGKZ LCK ARHH TNFAIP3 RASA2 PDPK1 LAT ITK CD8A SH2B3 PTPN6 REL GRB2 MAP4K1 MEF2D IKBKB NFKBIA VAV1 CHUK TRAF6 IKBKG MAP3K14 NFKB1 GNA13 DGKA TMEM222 ARIH2 PIK3R2 UBASH3A PIK3R1 RPRD1B FIBP CD5 AGO1 CDKN1B SH2D1A PRKCQ MELATONIN METABOLISM AND EFFECTS%WIKIPATHWAYS_20260510%WP3298%HOMO SAPIENS Melatonin metabolism and effects MAP2 ADRB1 CYP1B1 ASMT TRAF6 AANAT CYP1A1 NFKB1 APOE CALM1 MAOA CRY1 SIRT1 PER2 CYP2C19 GSK3B EDN1 PER1 CYP1A2 ACHE ECE1 PER3 MTNR1A MTNR1B PRKCA CSNK1D CSNK1E FOXO1 SULT1A1 CAMK2A IRAK1 CRY2 TOLL LIKE RECEPTOR SIGNALING RELATED TO MYD88%WIKIPATHWAYS_20260510%WP3858%HOMO SAPIENS Toll like receptor signaling related to MyD88 IKBKE TICAM1 IRF3 TLR4 IRF7 TLR7 RELA TLR3 REL IKBKB CHUK TRAF6 MAPK1 IKBKG IRAK4 NFKB1 RELB TRAF3 MYD88 TIRAP NFKB2 TLR8 TLR5 TICAM2 TLR1 IRAK1 TBK1 TLR9 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA%WIKIPATHWAYS_20260510%WP111%HOMO SAPIENS Electron transport chain OXPHOS system in mitochondria SCO1 NDUFA11 ATP5G1 HEL-S-271 NDUFC2 NDUFC1 SLC25A6 NDUFS8 NDUFS6 NDUFS5 SDHB NDUFS4 NDUFS3 NDUFS1 ND3 ND2 ND5 ND4 ND6 NDUFB8 NDUFB7 NDUFB10 NDUFB6 NDUFB5 NDUFB4 ATP6 NDUFB2 ATP5MC2 ATP5MC3 ATP5J NDUFB1 ATP5H HEL-S-123m UCP2 NDUFV3 NDUFV2 ATP5MG ATP5MF ATP5ME NDUFA9 DMAC2L NDUFA7 NDUFA6 NDUFA5 ATP5PB NDUFA3 NDUFA2 ND4L ATP5F1D ATP5F1E NDUFAB1 ATP5PO NDUFB9 SDHA SLC25A5 SDHC UQCRB SDHD UQCR11 UQCR10 CYB UQCRH UQCRQ UQCRC1 UQCRFS1 ND1 UQCRC2 COX7A1 SLC25A4 COX7B COX4I1 COX7A2 NDUFA10 COX6A1 NDUFA12 COX7C COX6A2 COX5A ATP5IF1 COX3 COX7A2L UCP3 COX2 SLC25A14 ATP8 NDUFB3 COX17 SLC25A27 COX8A UCP1 ZNF183 NDUFA13 COX11 SURF1 COX6B1 COXFA4 ALBUTEROL AND BUDESONIDE THERAPY FOR ASTHMA%WIKIPATHWAYS_20260510%WP5503%HOMO SAPIENS Albuterol and budesonide therapy for asthma CREB1 ADCY6 PLCB4 ADRB2 NR3C1 MYL1 MYL3 PLCB1 PLCB3 ADCY9 PRKAR1B MYL2 PLCB2 GNAS ADCY3 MYL4 PRKAR1A ADCY1 ADCY8 INTERLEUKIN 1 INDUCED ACTIVATION OF NF KB%WIKIPATHWAYS_20260510%WP3656%HOMO SAPIENS Interleukin 1 induced activation of NF kB UBE2V1 SQSTM1 TRAF6 AJUBA PRKCZ HEL-S-71 IRAK1 TIFA NFKB1 IL1A HAIR FOLLICLE DEVELOPMENT CYTODIFFERENTIATION STAGE 3 OF 3%WIKIPATHWAYS_20260510%WP2840%HOMO SAPIENS Hair follicle development cytodifferentiation stage 3 of 3 LRIG1 S100A4 KRTAP6-1 KRTAP2-4 KLK6 GSDMA KLK13 KLK14 FOXN1 KRT19 KRTAP8-1 NR3C1 CD200 CASP14 GJB6 SMAD4 IGFBP5 GPRC5D WIF1 IFNG DSC2 KITLG CTNNB1 MSX1 FOSB TCF4 CD34 GATA3 FOXQ1 SOX2 SMAD1 PERP DKK1 RUNX3 SFRP1 FST NFATC1 BMP6 JUN FOXE1 LEF1 BMPR1A DKK3 EGFR RBPJ IGF1 ZBTB16 ELANE TP63 FZD1 TCF3 GTPBP4 BMP4 GAS1 ATL1 DKK4 NFKB1 SOSTDC1 CD133 CTGF EGR2 NOTCH2 SOX9 NOTCH1 HR Nbla10317 HOXC12 KRTAP3-3 PHLDA1 KRTAP15-1 SPINK6 SPINK5 MSX2 ADAMTS20 DSG1 DSG4 GPR49 DLX3 FOS ADAM17 KLK5 KLK4 SARS COV 2 AND COVID 19 PATHWAY%WIKIPATHWAYS_20260510%WP4846%HOMO SAPIENS SARS CoV 2 and COVID 19 pathway CTSL FURIN ACE2 NRP1 TLR7 SCARB1 SLC6A19 ACAT1 TMPRSS2 TMPRSS4 FAMILIAL PARTIAL LIPODYSTROPHY%WIKIPATHWAYS_20260510%WP5102%HOMO SAPIENS Familial partial lipodystrophy BANF1 CIDEC MAPK9 PPARG STAT5B LMNA CIDEA NR1C1 ZMPSTE24 CEBPA FABP4 LIPE GATA3 LPL KLF2 KLF5 PLIN1 MGLL FNTA PIK3CA ICMT KLF9 PNPLA2 PRRX1 LMNB2 GATA2 INS OVERVIEW OF NANOPARTICLE EFFECTS%WIKIPATHWAYS_20260510%WP3287%HOMO SAPIENS Overview of nanoparticle effects LAMA3 BCL2 TNF IL6 HMOX1 NFRKB PTGS2 COL4A1 PTGS1 CRP CXCL8 BAX PIK3CD CCND3 AKT3 APOE AND MIR 146 IN INFLAMMATION AND ATHEROSCLEROSIS%WIKIPATHWAYS_20260510%WP3926%HOMO SAPIENS ApoE and miR 146 in inflammation and atherosclerosis APOE SPI1 NFKB2 TLR4 RELA TRAF6 IRAK1 METABOLISM OF TETRAHYDROCANNABINOL THC %WIKIPATHWAYS_20260510%WP4174%HOMO SAPIENS Metabolism of tetrahydrocannabinol THC CYP3A4 CYP2C9 GLYCOLYSIS AND GLUCONEOGENESIS%WIKIPATHWAYS_20260510%WP534%HOMO SAPIENS Glycolysis and gluconeogenesis SLC2A2 PC PKLR DLAT PCK1 GCK HK3 PGAM1 LDHB ALDOB DLD HEL-S-87p HEL-S-30 PGAM2 G6PC1 HEL-S-133P ENO1 HEL-S-68p PFKM HEL-S-162eP HEL-S-49 SLC2A4 MDH2 GOT2 PFKP SLC2A3 PFKL ENO2 ENO3 MPC1 PDHA1 HEL-S-32 MPC2 FBP2 HK2 FBP1 TCA CYCLE IN SENESCENCE%WIKIPATHWAYS_20260510%WP5050%HOMO SAPIENS TCA cycle in senescence ME1 BRAF FH PDHA1 PDP2 HEL-S-32 ME2 DISORDERS OF FOLATE METABOLISM AND TRANSPORT%WIKIPATHWAYS_20260510%WP4259%HOMO SAPIENS Disorders of folate metabolism and transport MTR SLC19A1 FOLR1 HEL-S-51e HEL-S-70p SHMT1 TYMS MTHFS MTHFD2L FTCD MTHFD1 MTHFD2 SLC46A1 DHFR IRON SULFUR CLUSTER BIOGENESIS%WIKIPATHWAYS_20260510%WP5152%HOMO SAPIENS Iron sulfur cluster biogenesis FDX1 FDXR HSCB CIAO2B NFU1 FXN NUBP1 NUBP2 ISCU NARF LYRM4 ABCB7 PATHWAYS OF NUCLEIC ACID METABOLISM AND INNATE IMMUNE SENSING%WIKIPATHWAYS_20260510%WP4705%HOMO SAPIENS Pathways of nucleic acid metabolism and innate immune sensing MITA IRF3 MAVS RIGI IFNB1 RNASEH2C RNASEH2B RNASEH2A RNASET2 ADAR TREX1 RNASEL CGAS OAS1 IFIH1 MITOCHONDRIAL COMPLEX I ASSEMBLY MODEL OXPHOS SYSTEM%WIKIPATHWAYS_20260510%WP4324%HOMO SAPIENS Mitochondrial complex I assembly model OXPHOS system NDUFC2 NDUFC1 NDUFS6 NDUFS5 NDUFS4 NDUFS3 NDUFS1 ND2 ND5 ND4 ND6 NDUFB8 NDUFB7 TMEM186 NDUFB10 C3orf60 NDUFB6 TMEM126B NDUFB5 DMAC1 NDUFB4 NDUFB11 DMAC2 NDUFB2 TMEM70 COA1 NDUFAF6 NDUFB1 NDUFAF4 NDUFV3 NDUFV2 NDUFA7 NDUFA6 NDUFA5 NDUFA3 NDUFA2 ND4L NDUFAB1 NDUFB9 NUBPL ND1 ACAD9 ECSIT TIMMDC1 NDUFA10 NDUFA12 NDUFAF2 NDUFAF1 NDUFB3 ZNF183 NDUFA13 TYPE III INTERFERON SIGNALING%WIKIPATHWAYS_20260510%WP2113%HOMO SAPIENS Type III interferon signaling IRF9 JAK1 STAT1 IF1IB1 IFNL2 IL10RB TYK2 IFNL3 STAT2 IFNLR1 MIRNA DEGRADING ENZYMES%WIKIPATHWAYS_20260510%WP4316%HOMO SAPIENS miRNA degrading enzymes XRN1 EXOSC4 PNPT1 P38 MAPK SIGNALING%WIKIPATHWAYS_20260510%WP400%HOMO SAPIENS p38 MAPK signaling CREB1 RASGRF1 MAX MAPKAPK2 GRB2 SMIM40 MEF2D MAPKAPK5 RPS6KA5 MAP3K1 STAT1 TRADD MAPK14 MYC RAC1 MAP2K6 HRAS TGFBR1 CDC42 HMGN1 TRAF2 RIPK1 MAP2K4 SHC1 MAP3K7 DDIT3 MAP3K5 HEL-S-102 ATF2 LACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260510%WP5303%HOMO SAPIENS Lacto series sphingolipid metabolism FUT2 FUT3 B3GNT5 B3GALT1 FUT1 B3GALT2 TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP75%HOMO SAPIENS Toll like receptor signaling MAP2K3 TLR4 MAPK12 MAPK11 CASP8 RELA FADD MAPK9 MAPK8 IL12B MAP3K8 MAPK3 IL12A STAT1 MAPK14 IRAK4 AKT3 CCL5 LY96 CCL4 CCL3 MAP2K2 CXCL11 LBP MYD88 TIRAP MAP2K4 JUN TLR5 CD14 IFNA1 MAP3K7IP1 TLR1 IF1AA9 IRAK1 TBK1 TLR9 IKBKE IFNA13 TICAM1 IFNA14 IRF3 MAPK10 NFKBIB IFNA16 IRF7 TLR7 IFNA17 TLR3 IFNA10 IFNA21 TAB3 IKBKB IL1B NFKBIA CXCL9 CHUK TRAF6 MAPK1 IKBKG RAC1 IFNA4 NFKB1 IFNA7 MAP2K6 MAPK13 IFNA6 IFNA2 IFNA8 IFNAR2 TNF IL6 TRAF3 IFNAR1 SPP1 RIPK1 IFNB1 CD40 CXCL8 MAP3K7 TLR8 CD80 TICAM2 MAP2K1 FOS LEUKOTRIENE METABOLIC PATHWAY%WIKIPATHWAYS_20260510%WP5171%HOMO SAPIENS Leukotriene metabolic pathway PTGR1 ALOX5 DECR2 DPEP2 CYP4F3 ABCC1 DECR1 ALOX5AP LTC4S EBSTEIN BARR VIRUS LMP1 SIGNALING%WIKIPATHWAYS_20260510%WP262%HOMO SAPIENS Ebstein Barr virus LMP1 signaling TNF RELA MAPK8 IFNB1 CXCL8 TRAF1 NFKB2 IKBKB NFKBIA MAP3K7 CHUK TRADD TRAF6 PDLIM7 MAPK1 CCL20 IKBKG MAP3K14 NFKB1 IRAK1 CCL5 UDP DERIVED SUGARS SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260510%WP5394%HOMO SAPIENS UDP derived sugars synthesis in fibroblasts GCK UGDH PGM3 UXS1 HK3 GFPT1 HK2 DIET DEPENDENT TRIMETHYLAMINE TRIMETHYLAMINE N OXIDE METABOLISM %WIKIPATHWAYS_20260510%WP5219%HOMO SAPIENS Diet dependent trimethylamine trimethylamine N oxide metabolism ALDH7A1 SLC44A1 CHDH PURINERGIC SIGNALING%WIKIPATHWAYS_20260510%WP4900%HOMO SAPIENS Purinergic signaling GNAZ GNAI1 GNA11 PANX1 GNAO1 LPAR4 P2RY13 GNAS P2RY11 P2RY1 P2RY8 GNAT2 GNAT3 GNAT1 P2RY10 P2RY14 P2RX7 P2RX6 P2RX5 P2RX4 ADORA2A P2RX3 P2RX2 P2RX1 P2RY6 P2RY4 GNAI3 ADORA2B P2RY2 TCA CYCLE AKA KREBS OR CITRIC ACID CYCLE %WIKIPATHWAYS_20260510%WP78%HOMO SAPIENS TCA cycle aka Krebs or citric acid cycle OGDH SUCLG2 MDH2 SDHC SDHD SUCLA2 SUCLG1 SDHB ACO2 IDH3B DLD FH SDHA CS MITOCHONDRIAL BETA OXIDATION%WIKIPATHWAYS_20260510%WP5241%HOMO SAPIENS Mitochondrial beta oxidation ACSL3 ACADL EHHADH HSD17B10 ACADSB DECR1 ECHS1 GLYCOSAMINOGLYCAN DEGRADATION%WIKIPATHWAYS_20260510%WP4815%HOMO SAPIENS Glycosaminoglycan degradation GUSB HEXB HEXA HGSNAT HPSE2 IDUA GNS SGSH GALNS HYAL2 HYAL4 GLB1 HPSE MAPK SIGNALING%WIKIPATHWAYS_20260510%WP382%HOMO SAPIENS MAPK signaling MAPK8IP2 DUSP3 MAP2K3 MAP2K5 RELA CACNA1H PTPN5 MAPK9 MAPK8 IL1R1 IL1A MAP3K8 MAPK3 TGFB1 JUND DUSP10 BRAF MAPK14 FGF2 FGF7 FGF8 FGF9 JUN FGF20 CD14 FGF23 FGF22 MAP3K7IP1 FGF21 HEL-S-102 STK4 FLNA FGF16 FGF14 FGF18 FGF13 FGF12 FGF10 FGF8A RAC3 RRAS2 FGF7B FGF7A FGF6B CDC42 CACNA1I FGF5C RAP1A MAP3K7 SMIM40 CACNG2 MYC AKT3 PPP3CA HRAS RASGRF2 TGFBR1 MAP2K2 PLA2G4F PLA2G4D PLA2G4E PLA2G4B PLA2G4C RASA2 NLK NFATC1 SOS1 MAPK8IP1 SOS2 EGFR CACNA2D1 NTRK1 LRRK2 NTRK2 KRAS GRB2 FGFR4 FGFR3 FGFR2 FGFR1 IL1B MAPK7 NTF3 ARAF RPS6KA5 RAC1 BDNF NRAS PAK1 GADD45A NF1 HSPA2 RASGRF1 CDC25B MAPKAPK3 MAPKAPK2 DUSP2 PRKACG NFATC3 CACNA1G RPS6KA4 ATF2 MAP3K13 MAP3K12 MEF2C MAPK8IP3 DUSP8 DUSP9 DUSP7 RAPGEF2 MAP3K11 TAOK3 TAOK2 DUSP16 PPM1B pk PPP5C MAX IKBKB LAMTOR3 MAPKAPK5 MAP3K1 CHUK RRAS TRAF6 MAPK1 IKBKG RAF1 MAP3K14 NFKB1 MAP2K6 MAPK13 TRAF2 RELB NGF RASGRP4 RASGRP3 PRKCA IL1R2 CACNB1 TNFRSF1A CACNB3 RPS6KA3 CACNA1B CACNA1A MAPK12 MAPK11 CACNA1C TNFSF6 CACNA1S GNG12 PPP3R2 FAS CACNA2D3 CACNA2D2 CACNA2D4 CACNB4 CACNA1F CACNG6 CACNG7 CACNG8 ARRB2 CACNG1 CACNG3 CACNG4 CACNG5 CRKL DUSP4 MAP2K4 DDIT3 CRK HEL-S-103 FLNB EGF MAPK10 PDGFA MAP3K2 MAP4K1 MAP4K2 PPP3CC NTF4 MAP4K3 HEL-S-72p ATF4 ECSIT PPP3R1 TNF MAP3K6 TGFBR2 NFKB2 HEL-S-31 CASP3 MAP3K5 TAOK1 MAP2K1 FOS OXIDATION BY CYTOCHROME P450%WIKIPATHWAYS_20260510%WP43%HOMO SAPIENS Oxidation by cytochrome P450 CYP2A13 CYP2F1 CYP4B1 CYP1B1 CYP11A1 CYP2W1 CYP20A1 POR CYP7A1 CYP8B1 CYP4F2 CYP4A22 CYP4F12 CYP7B1 CYP27A1 CYP4Z1 CYP3A7 CYP2U1 CYP4F22 CYP2C18 CYB5R1 CYB5R4 CYP2B6 CYP4X1 CYB5B CYP27B1 CYP24A1 CYP17A1 CYP46A1 CYP2J2 CYP2A6 CYP4F3 CYP11B2 CYP4F11 CYP4F8 CYB5R3 CYP26A1 CYP1A1 CYP2E1 CYP27C1 CYP2S1 CYP4A11 CYP26B1 CYP4V2 CYP3A4 CYP2R1 CYP2C19 CYP2C9 CYP2C8 CYP1A2 CYP3A43 CYP2A7 CYP26C1 CYP51A1 ALPHA 6 BETA 4 SIGNALING%WIKIPATHWAYS_20260510%WP244%HOMO SAPIENS Alpha 6 beta 4 signaling LAMA3 LAMB3 LAMB2 MTOR LAMA5 LAMB1 GRB2 MAPK3 MAPK1 MAPK14 RAC1 ARHA HRAS PIK3R2 PIK3R1 PTPN11 SOS1 SHC1 ITGB4 SRC PRKCA LAMC2 IRS1 ITGA6 LAMC1 EIF4EBP1 LAMA1 DEVELOPMENT OF URETERIC DERIVED COLLECTING SYSTEM%WIKIPATHWAYS_20260510%WP5053%HOMO SAPIENS Development of ureteric derived collecting system NR1B3 RARB ANOS1 SHH GRIP1 BMPER GPC3 CRIM1 ETV4 CTDNEP1 SMO BMP4 FRAS1 FREM1 TGFB1 FREM2 SPRY1 CCND1 GDF11 BMP7 PAX2 SMAD1 SIX2 DCN RARA FST BMP2 RET BMP5 BMPR1A BMPR2 HOXD11 SIX1 GDNF CELSR1 HOXA11 ETV5 SALL1 GLI3 EYA1 MIR TARGETED GENES IN SQUAMOUS CELL%WIKIPATHWAYS_20260510%WP2006%HOMO SAPIENS miR targeted genes in squamous cell DKFZp761E1322 SH3BGRL3 POLD2 SYNE2 GAS2L1 SEC23A MAP3K8 HSD17B12 CBFB HES1 AP3D1 ARCN1 FMNL2 GALNT7 GALNT1 BET1 SPTLC1 FGF2 TNFRSF10B PRPF40A SMAD1 AP2A1 ELOVL5 FBXW11 DNAJB1 LAMC1 HEL-S-26 TPM3 ANXA2 DHX57 HOXA7 POLR2C PICALM HEL-S-30 PEDS1-UBE2V1 MRPS33 TMEM59 SIGMAR1 NRP1 GYS1 HMOX1 CUL4B AXL PPP1R7 SH3BP4 SDCBP VCAM1 ATP2A2 TUBA1A YWHAQ MET P4HA2 CPNE8 NCL VEZT PWP1 CIAO2A FNDC3B FNDC3A UBE2J1 COMMD9 ATP6V1C1 HMGA1 MOV10 RHEB ANP32B MAGT1 TMED7 PNP PDLIM7 GOLGA7 CSDE1 THBS1 PXDN ATP6V0E1 PISD MPZL1 RAB34 RNP24 AKAP8 POM121 TGFBR2 NEDD4 ADIPOR2 RTN4 LAMTOR5 E2F3 MRPL20 POGLUT3 ATP6V1F SLC38A1 RARS1 TPM1 NF2 TBCA PTMAP7 ARF4 SLC12A2 SRSF9 TRAM1 TMED10 RAI14 ADAR GFPT1 SLC4A10 MRC2 CTDSP1 TMEM43 SPCS3 CHMP2A SRPRB NCRNAS INVOLVED IN STAT3 SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260510%WP4337%HOMO SAPIENS ncRNAs involved in STAT3 signaling in hepatocellular carcinoma JAK1 STAT3 SOX4 IL6 IL6ST RELA IL11 IL11RA JAK3 NFKB1 IL6R AGE RAGE PATHWAY%WIKIPATHWAYS_20260510%WP2324%HOMO SAPIENS AGE RAGE pathway CASP8 RELA PRKCZ NCF1 MAPK9 MAPK8 MAPK3 STAT5B STAT1 MAPK14 IRAK4 SMAD2 AGER CYCS ARHA SP1 INHBB DDOST HEL-S-44 HIF1A HEL70 MYD88 TIRAP EZR JUN SHC1 SRC EGFR FOXO1 ATF2 INSR STAT3 MMP7 NOS2 ALPL FOXO4 IKBKB MMP14 NFKBIA MSR1 CHUK MAPK1 RAC1 RAF1 ROCK1 MMP2 NFKB1 MMP9 CDC42 CASP9 PRKCB PRKCA CASP3 IRS1 MAP2K1 INS MIRNA ROLE IN IMMUNE RESPONSE IN SEPSIS%WIKIPATHWAYS_20260510%WP4329%HOMO SAPIENS miRNA role in immune response in sepsis TLR4 IRF7 TLR7 RELA ELANE REL MAPK8 IL10 IL1A IKBKB NFKBIA IRF1 CHUK TRAF6 MAPK14 IKBKG IRAK4 NFKB1 CCL4 CCL3 TNF VCAM1 RELB IL6 LCN2 TRAF3 MYD88 CXCL8 NFKB2 MAP3K7 TLR8 MAP3K7IP1 IRAK1 BDNF TRKB SIGNALING%WIKIPATHWAYS_20260510%WP3676%HOMO SAPIENS BDNF TrkB signaling CREB1 MTOR GAB2 ARC RHEB KRAS GRB2 PLCG1 RPS6KB1 BRAF MAPK1 HRAS BDNF TSC2 NRAS TSC1 RPS6KA1 EEF2K TRPC6 TRPC3 SOS1 SHC1 HOMER1 GRIN1 DLG4 MAP2K1 ADCY1 EIF4EBP1 NTRK2 ATM SIGNALING%WIKIPATHWAYS_20260510%WP2516%HOMO SAPIENS ATM signaling CREB1 CHEK1 MRE11A NBN BRCA1 PIDD1 MDM2 MAPK9 RAD9A CDKN1A TP73 CCNB1 MDC1 IKBKG CDC2 CRADD CDK2 TLK1 SMC1A CASP2 RIPK1 TP53BP1 GADD45A MDM4 JUN H2AX CCNE1 ATM ATF2 RAD50 CHEK2 RAD51 PENTOSE PHOSPHATE METABOLISM%WIKIPATHWAYS_20260510%WP134%HOMO SAPIENS Pentose phosphate metabolism RPIA HEL-S-304 RPE HEL107 ANGIOGENESIS%WIKIPATHWAYS_20260510%WP1539%HOMO SAPIENS Angiogenesis PDGFRA ANGPT1 HIF1A SMAD1 TIMP3 FLT1 PLCG1 FGFR2 VEGFA PIK3CA CREBBP SRC MAPK14 MAPK1 KDR MMP9 FGF2 SPHINGOLIPID METABOLISM IN SENESCENCE%WIKIPATHWAYS_20260510%WP5121%HOMO SAPIENS Sphingolipid metabolism in senescence CDK2 SPHK1 SGMS2 MTOR S1PR5 UGCG KDSR TERT CERS2 CDKN1A PLCB1 CDK4 PRKCB RPP38 PRKCA S1PR1 RB1 MAPK1 S1PR2 SGPP1 SPTLC1 DEGS1 GLB1 WNT BETA CATENIN SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260510%WP5529%HOMO SAPIENS Wnt Beta catenin signaling and ARTD family members BTRC TNK1 CTNNB1 SKP1 APC RBX1 TNK2 DVL1 DVL2 DVL3 AXIN1 PLK1 PARP1 PARP10 GLYCOSYLATION AND RELATED CONGENITAL DEFECTS%WIKIPATHWAYS_20260510%WP4521%HOMO SAPIENS Glycosylation and related congenital defects B4GALT1 ALG11 ALG6 DPM3 GCS1 TUSC3 DPM2 MPDU1 MAGT1 MGAT2 SRD5A3 DPM1 DOLK DPAGT1 GMPPB ALG8 ALG9 ALG1 ALG2 ALG14 ALG13 ALG3 ALG12 PREGNANE X RECEPTOR PATHWAY%WIKIPATHWAYS_20260510%WP2876%HOMO SAPIENS Pregnane X receptor pathway DNAJC7 RXRA ABCC3 ABCC2 UGT1A9 ABCB1 CYP3A4 CYP2B6 CYP2C19 CYP2C9 UGT1A4 CYP4F12 UGT1A3 SRC SRPX2 NCOA1 SLCO1B1 FOXO1 CYP2A6 UGT1A1 SULT2A1 NR1i2 CYP3A7 PPARGC1A PPAR SIGNALING%WIKIPATHWAYS_20260510%WP3942%HOMO SAPIENS PPAR signaling AQP7 PCK1 UBC PPARG OLR1 HEL-S-28 NR1C2 PCK2 SLC27A1 APOA2 APOC3 NR1H3 NR1C1 CD36 DBI FABP4 CYP7A1 APOA5 CYP8B1 FABP1 RXRA CPT2 ME1 CYP4A11 EHHADH ANGPTL4 LPL PLTP CPT1C PLIN1 SLC27A4 ACSL1 UCP1 PDPK1 FADS2 CYP27A1 SCD RXRB ACOX1 SLC27A5 RXRG ARIPIPRAZOLE METABOLIC PATHWAY%WIKIPATHWAYS_20260510%WP2640%HOMO SAPIENS Aripiprazole metabolic pathway CYP3A43 GLYCEROPHOSPHOLIPID BIOSYNTHETIC PATHWAY%WIKIPATHWAYS_20260510%WP2533%HOMO SAPIENS Glycerophospholipid biosynthetic pathway GPD1 PLA2G2A PTDSS1 GNPAT CHKB CDIPT PCYT2 CEPT1 AGPS PIK3CD PGS1 GPAT2 LPIN1 CDS2 PTPMT1 IPMK CRLS1 MOGAT3 GPAT4 GPAM PEMT PIK3CA HMFN0839 PIP5K1A LPIN2 PI4K2A P53 TRANSCRIPTIONAL GENE NETWORK%WIKIPATHWAYS_20260510%WP4963%HOMO SAPIENS p53 transcriptional gene network APAF1 BBC3 E2F7 PRKAA2 MGMT SLC7A11 XPC TNFSF6 TIGAR NCF2 SFN CDKN1A PTEN TP53INP1 ULK1 ERCC5 RPTOR DEPTOR FAS MLST8 CCL2 CDK2 TSC2 TNFRSF10B TP53AIP1 ZMAT3 AKT1S1 PERP FANCC ULK2 FUCA1 XRCC5 LIF PCNA TNFRSF10D BTG2 ADORA2B IRF9 AURKA PML MTOR MSH2 PIDD1 GLS2 CCNG1 RRM2B TRAF4 PRKAB2 SMR3B PRKAB1 ACAD11 THBS1 SERPINB5 POLK SCO2 ADGRB1 CX3CL1 DRAM1 DDB2 RPRM SIVA1 ULBP2 SESN1 ULBP1 TNF SESN2 DDIT4 PRKAG1 PRKAG2 PRKAG3 CPT1C PRKAA1 GPX1 NOTCH1 PMAIP1 GADD45A BAX TP53I3 CCNE1 ISG15 CEREBRAL ORGANIC ACIDURIAS INCLUDING DISEASES%WIKIPATHWAYS_20260510%WP4519%HOMO SAPIENS Cerebral organic acidurias including diseases ALDH7A1 L2HGDH MDH2 D2HGDH HEL-S-5 ADHFE1 GCDH ANDROGEN BIOSYNTHESIS%WIKIPATHWAYS_20260510%WP5393%HOMO SAPIENS Androgen biosynthesis HSD11B1 HSD11B2 POR CYP3A4 AKR1C2 AKR1D1 CYP17A1 AKR1C4 HSD17B3 SRD5A2 AKR1C1 HSD17B2 HSD3B2 HSD3B1 HSD17B1 SULT2A1 HSD17B4 CYP3A7 NO CGMP PKG MEDIATED NEUROPROTECTION%WIKIPATHWAYS_20260510%WP4008%HOMO SAPIENS NO cGMP PKG mediated neuroprotection CREB1 CNGA1 RELA PDE3A NOS2 CNGB1 GUCY1A2 CAMK2G IL1B NFKBIA ACTN2 GUCY1B1 NFKB1 AKAP9 CYCS PBR IFNG BCL2 CALM1 TNF CNGA3 CNGA4 CNGB3 BAD NEFL CASP9 CAMK2D GRIN2B NPPB GRIN1 DLG4 CAMK2A NPPA PDE2A RESOLVIN E1 AND RESOLVIN D1 SIGNALING DECREASE INFLAMMATION%WIKIPATHWAYS_20260510%WP5191%HOMO SAPIENS Resolvin E1 and resolvin D1 signaling decrease inflammation PIK3CA EPHB2 PIK3CD LTB4R MTOR CMKLR1 FPR2 GRK1 PROGERIA ASSOCIATED LIPODYSTROPHY%WIKIPATHWAYS_20260510%WP5103%HOMO SAPIENS Progeria associated lipodystrophy RECQL MUCL3 SPRTN BANF1 PPARG KCNJ6 FNTA TGFB1 WRN ICMT FFAR3 LMNA SMAD2 SMAD4 LMNB2 FBN1 PARP1 INS ZMPSTE24 22Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP4657%HOMO SAPIENS 22q11 2 copy number variation syndrome RBX1 NKX2-5 SHOC2 HES1 GLUD1 PAX3 PLK1 BCL2 VWF FGF8 GP9 SERPIND1 CLDN3 P2RX6 FOXC1 CDC45 EMC10 CLDN1 FGF10 UFD1L H4C9 RAF1 CYP26A1 CDC42 SLC2A4 MED15 PRODH DRD2 TSKS CYP26B1 HIRA ZDHHC8 RCC1 C22orf39 HIRIP3 THAP7 TSSK2 RTL10 NPRL2 HAND2 TRMT2A ESS2 KLHL22 DGCR8 GP5 SNAP29 DROSHA LRRC74B FOXC2 SEPT8 MRPL40 RAN DGCR6L TNPO1 SCARF2 DGCR2 CYP26C1 GP1BB C16orf35 GSC2 SLC7A4 GNB1L NCOR1 DEPDC5 CCDC188 ARVCF RANBP1 ZNF74 PARK2 RELN HEL-S-80p HDAC3 RORC HEL25 GBX2 PITX2 CRKL RTN4R CLTCL1 EGFR PAK4 SEPT5 SHH FGFR2 FOXA2 FGFR1 ASF1A GP1BA RTN4 ALDH1A2 SREBF2 TXNRD2 CLDN5 SLC25A1 CDH15 ACTA2 TBX1 POLR2A INTEGRATIVE ANALYSIS OF TREG GLIAL INTERACTIONS %WIKIPATHWAYS_20260510%WP5561%HOMO SAPIENS Integrative Analysis of Treg Glial Interactions HEXB OLIG2 TLR4 IKZF2 CCN3 IL2RG NKX6-2 KLRG1 JAK3 MCAM TMEM119 OLIG1 IL10 FOXO3A JAK1 IL12A STAT5B TGFB1 MOG STAT1 IGF1R MAPK14 SMAD2 IL2 HTR7 STAT4 TYK2 IL12RB1 IL10RB FOXP3 IL10RA TGFBR1 PDGFRA IFNG NKX6-1 NKX2-2 CXCL12 SOCS3 IL2RB MYD88 AREG IL4 TNFRSF1B IL2RA ITGB3 EGFR FOXO1 CSPG4 ITGAV IGF1 CNP AIF1 STAT3 CD68 SIRPA CTLA4 CCR8 TGFBR3 PDCD1 CCR6 PDGFA NOS2 SSTR2 FAM20C GSDMD ROS1 CD44 FOXO4 CCL1 IL1B CD47 CXCL1 CCL20 RAC1 IL33 ITGA2 APOD NFKB1 IL18 MMP9 MBP CDC42 TNF TGFBR2 IL6 OSM SPP1 NLRP3 SOX9 VEGFA NFKB2 CD80 EBI3 CX3CR1 DNA REPLICATION%WIKIPATHWAYS_20260510%WP466%HOMO SAPIENS DNA replication POLD2 POLE RFC3 RFC4 RFC1 RPA4 RFC2 UBC POLA2 PRIM1 GMNN POLD3 ORC6 ORC3 ORC2 CDT1 RPA1 CDC6 POLA1 POLE2 RPA3 CDK2 MCM7 ORC1L MCM10 DBF4 MCM3 MCM5 MCM6 MCM2 PCNA CDC45 PRIM2 POLD4 APOPTOSIS REGULATION BY PARATHYROID HORMONE RELATED PROTEIN%WIKIPATHWAYS_20260510%WP3872%HOMO SAPIENS Apoptosis regulation by parathyroid hormone related protein BCL2 BCL2L2 MCL1 PTHLH BAK1 BCL2A1 BCL2L1 GSK3A BOK BCL2L12 BCL2L14 GSK3B BAX ITGB4 BCL2L13 BCL2L10 ITGA6 MYC AKT3 AGE RELATED MACULAR DEGENERATION%WIKIPATHWAYS_20260510%WP5526%HOMO SAPIENS Age related macular degeneration MTOR PRKAA2 PARP2 SIRT1 PRKAG1 PRKAG2 PRKAA1 PRKAG3 PMAIP1 MAPK3 PRKAB2 RPTOR RPS6KB1 PRKAB1 HEL-S-32 MLST8 PPARGC1A CONSTITUTIVE ANDROSTANE RECEPTOR PATHWAY%WIKIPATHWAYS_20260510%WP2875%HOMO SAPIENS Constitutive androstane receptor pathway DNAJC7 CYP2B6 PTPA UGT1A4 UGT1A3 NCOA1 CYP2A6 UGT1A1 SP1 RXRA CYP4A11 SMC1A ABCC3 EHHADH UGT1A9 ABCC2 ABCB1 CYP3A4 CYP2C19 CYP2C9 ALAS1 FOXO1 SULT1A1 SULT2A1 NCOA6 NR1I3 PPARGC1A AXON GUIDANCE%WIKIPATHWAYS_20260510%WP5289%HOMO SAPIENS Axon guidance EPHB1 NRP1 SEMA3A PLXNA1 PRKCZ PARD6A SEMA5B ROBO3 DPYSL5 UNC5D HEL-S-28 SEMA7A EFNB1 ABLIM3 LRIG2 SRGAP2 TRPC1 NTNG2 NGL1 CXCR4 HRAS NTN3 L1CAM CXCL12 NCK1 MET PDPK1 EPHA2 WNT4 HEL-S-15 SRC ROBO2 RYK BMPR2 ROBO1 RGMA FES GNAI1 SLIT1 ITGB1 FYN SLIT3 SLIT2 SHH RHOD PTCH1 BOC CDK5 FZD3 RRAS MAPK1 RAC1 RAF1 ROCK1 CDC42 gdf7 MYL12B EFNA1 PARD3 GSK3B PRKCA ARHGEF12 DCC NITRIC OXIDE METABOLISM IN CYSTIC FIBROSIS%WIKIPATHWAYS_20260510%WP4947%HOMO SAPIENS Nitric oxide metabolism in cystic fibrosis PRMT1 HEL-S-277 PRMT7 NOS2 PRMT2 PRMT3 PRMT6 CARM1 AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20260510%WP521%HOMO SAPIENS Amino acid conjugation of benzoic acid ACSS2 GATF-C GLYATL2 CANCER IMMUNOTHERAPY BY CTLA4 BLOCKADE%WIKIPATHWAYS_20260510%WP4582%HOMO SAPIENS Cancer immunotherapy by CTLA4 blockade PPP2CA PIK3CA PIK3R3 PIK3R2 PIK3CD CTLA4 PIK3R1 PTPN6 CD80 HLA-DRB1 PTPN11 CILIOPATHIES%WIKIPATHWAYS_20260510%WP4803%HOMO SAPIENS Ciliopathies TULP1 CEP164 ALMS1 DYNC2I2 C2CD3 TRAF3IP1 CEP19 IFT172 GLI3 IFT52 RP1L1 DNAJB13 TCTN3 TCTN2 TMEM107 TCTN1 ZIC2 CNGA1 NEK1 BBS9 BBS7 CFAP418 CFAP410 PKD1 IFT57 RP2 MAK CC2D2A EFHC1 BBS5 CNGB1 BBS4 SDCCAG8 DYNC2H1 CRX OFD1 PKD1L1 PKHD1 SMO INTU IFT140 PDE6D NPHP3 HEL-S-296 USP9X IFT80 PCARE RPGRIP1L GPR161 DCDC2 WDR35 CEP41 LZTFL1 TRIM32 BBS10 PLK4 IFT43 NEK8 EVC BBS12 IFT81 TMEM216 CCDC41 WDPCP BBIP1 CEP104 SUFU RSPH9 KIF7 ARL6 ARL3 DYNLT2B DYNC2LI1 ARL13B RSPH3 TMEM67 RAB23 INPP5E CEP290 KIAA0753 PIBF1 IQCB1 EVC2 BBS2 BBS1 PIK3R4 SCLT1 CPLANE1 TMEM231 TTC8 TMEM17 MKS1 IFT27 B9D1 CCDC40 CLUAP1 TMEM138 RSPH1 ANKS3 NPHP1 INVS SPAG1 TMEM237 UNC119 B9D2 ODAD1 ODAD3 ODAD4 CCDC28B MCIDAS TBC1D32 NEK2 XPNPEP3 DNAAF3 DNAAF2 DNAAF6 FAM161A CCNQ CCNO DRC1 AK7 CEP78 DNAAF19 ARL2BP DNAL1 DNAAF11 HYDIN FLCN CCDC39 DNAI2 CFAP52 TOPORS RP1 NME9 WDR51B ZMYND10 KIZ CFAP53 KATNIP DNAH6 CFAP298 POC1A RAB28 DNAI1 TUB DYX1C1 ADCY6 RPGRIP1 TTLL5 HYLS1 ATXN10 OCRL ZNF423 AHI-1 NEK9 NME7 CENPF METHIONINE METABOLISM LEADING TO SULFUR AMINO ACIDS AND RELATED DISORDERS%WIKIPATHWAYS_20260510%WP4292%HOMO SAPIENS Methionine metabolism leading to sulfur amino acids and related disorders pcap CBS MAT1A HEL-S-182mP MTR CDO1 ADK CTH HEL-S-61p PI3K AKT SIGNALING%WIKIPATHWAYS_20260510%WP4172%HOMO SAPIENS PI3K Akt signaling CREB1 EIF4B TLR4 PHLPP1 ANGPT4 CSF1 PRKAA2 RELA IL2RG JAK3 PKN3 PKN2 PKN1 MAPK3 PPP2R2A PPP2R1B PPP2R1A IL2 PPP2R5B IGF2 PPP2R5A PPP2R5D PPP2R3B FGF2 XB BCL2 PPP2R3A FGF7 PPP2R2C FGF8 PPP2R2B FGF9 F2R PIK3CA FGF20 TNC VEGFC IFNA1 FGF23 FGF22 FGF21 IGF1 FGF14 FGF18 CSF3 FGF13 PCK1 IL7 FGF12 FGF10 FGF8A ITGA1 FGF7B FGF7A PRLR FGF6B VEGFB GH1 OSM SGK1 FGF5C PRL GYS1 CDKN1A FLT1 FLT3 ITGA4 FLT4 PTEN FLT3LG PIK3CD IGF1R RPTOR THBS2 COL9A1 CCND1 MYC AKT3 COL9A3 KDR MLST8 HRAS IL6R PDGFRA MAP2K2 ANGPT2 TSC2 TSC1 ANGPT1 CD19 IL3 IL2RB KIT SOS1 COL9A2 SOS2 IL4 MET EPHA2 CSF1R IL2RA EGFR ITGB3 ITGA6 ITGAV NTRK1 NGFR NTRK2 INSR MTOR BRCA1 RHEB MDM2 PPP2R5E KRAS GRB2 PPP2R5C FGFR4 COL4A2 FGFR3 FGFR2 FGFR1 NTF3 HEL-S-125m THBS1 RAC1 ITGA2 ITGB7 PIK3R3 PIK3R2 BDNF PIK3R1 NRAS TCL1B BAD TCL1A PHLPP2 CSHL1 GHB3 ITGB4 CCND3 CDKN1B CCNE1 PPP2R3C PPP2R2D CCND2 CCNE2 GYS2 GHR OSMR COL6A1 CDC37 PPP2CA CDK2 VWF RBL2 KPG_010 LAMC1 ATF2 IF1AA9 ITGB5 ITGB8 CSF3R ITGA7 ITGA2B IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 IFNA21 CDK6 HSP90AB1 CDK4 IKBKB CHUK LPAR2 MAPK1 LPAR3 IKBKG LPAR4 RAF1 IFNA4 NFKB1 IFNA7 IFNA6 CHRM2 IFNA2 IFNA8 CHRM1 IFNAR2 VEGFD IBSP IFNAR1 SPP1 COL4A1 COL4A4 IFNB1 GHB2 COL4A3 COL4A6 NGF COL4A5 COL1A1 COL2A1 PRKCA IL7R LAMC2 IRS1 INS PIK3R5 LAMA1 LAMA4 MCL1 LAMA3 LAMB3 LAMB2 LAMB4 LAMB1 RELN BCL2L11 TNFSF6 BCL2L1 VTN GNG12 FOXO3A GNG11 GNG13 JAK1 SYK RPS6 RPS6KB1 RPS6KB2 PCK2 G6PC1 GNB2 G6PC2 G6PC3 GNB1 GNB4 GNB3 EPO GNB5 EPOR KITLG IL3RA ITGB6 GNGT1 COL1A2 PDPK1 TGFA EIF4EBP1 EGF GNG3 ITGB1 PDGFD LAMA5 GNG2 PDGFC HGF GNG5 PDGFA CSH2 GNG4 EIF4E1B COL6A6 GNG7 COL6A5 GNG8 ATF6B CREB3L3 CREB3L4 CREB3L2 GNGT2 NTF4 COMP CREB3 TNR PIK3AP1 CREB5 ATF4 CHAD STK11 DDIT4 IL6 EFNA5 GNG10 EFNA4 EFNA1 PRKAA1 EFNA3 THBS4 THBS3 EFNA2 GSK3B EIF4E LPAR1 VEGFA CASP9 SGK2 MAP2K1 MYB ANGIOTENSIN II RECEPTOR TYPE 1 PATHWAY%WIKIPATHWAYS_20260510%WP5036%HOMO SAPIENS Angiotensin II receptor type 1 pathway TGFBR2 ACE2 CTGF PDGFD HIF1A COL1A2 PTPN11 MGRA COL1A1 TGFB1 JUND RRAS IL6ST IL11 MAPK1 IL11RA AGTR1 SMAD4 RAF1 ACTA2 MAP2K6 NOX4 TGFBR1 SP1 TLR4 SIGNALING AND TOLERANCE%WIKIPATHWAYS_20260510%WP3851%HOMO SAPIENS TLR4 signaling and tolerance INPP5D IKBKE TICAM1 IRF3 TLR4 IRF7 IKBKB NFKBIA CHUK TRAF6 IKBKG IRAK4 NFKB1 TNF IL6 TRAF3 MYD88 RIPK1 TIRAP IFNB1 CXCL8 MAP3K7 TRAM1 IRAK3 MAP3K7IP1 IRAK1 TBK1 ERK PATHWAY IN HUNTINGTON 39 S DISEASE%WIKIPATHWAYS_20260510%WP3853%HOMO SAPIENS ERK pathway in Huntington 39 s disease CREB1 MAP2K2 EGF BDNF MAPK3 HTT RPS6KA5 CASP3 EGFR MAPK1 RAF1 MAP2K1 NTRK2 HRAS FARNESOID X RECEPTOR PATHWAY%WIKIPATHWAYS_20260510%WP2879%HOMO SAPIENS Farnesoid X receptor pathway CYP7A1 CYP8B1 RXRA FGF8A NR0B2 CYP3A4 FKBP5 ABCB4 BAAT ABCB11 NR1H4 SLC27A5 SULT2A1 SLCO2B1 UGT2B4 PPARGC1A IP6K3 NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN NOD PATHWAY%WIKIPATHWAYS_20260510%WP1433%HOMO SAPIENS Nucleotide binding oligomerization domain NOD pathway RIPK2 DUOX2 RELA CASP8 PRDM1 NOD1 NLRC4 MEFV AAMP CARD8 CARD9 CARD6 NLRP12 IKBKB ACAP1 IL1B NFKBIA NLRP10 CASP5 CHUK NLRP7 NLRP2 IKBKG RAC1 NLRP1 IL18 PYCARD COPS6 NLRP3 NDUFA13 CASP9 ERBIN NAIP AIM2 NOD2 7Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP4932%HOMO SAPIENS 7q11 23 copy number variation syndrome BAZ1B ATP5G1 GTF2I HEL-S-271 GRIP1 ACACA SMARCA5 DEK USF1 RFC2 CHTF18 HDAC3 MAPK3 ULK1 DLD ACACB BTK SNAP25 MYC FAS FBN1 STX1A ATP6 ATP5MC2 NUP62 ATP5MC3 EIF2A CTNNB1 CDKN1C HDAC6 VAMP2 HEL-S-123m MYBBP1A CLTC CLDN3 TSG101 ATP5PB NRG1 HEL-S-15 ATPAF2 HDAC2 PCNA ATP5F1D ATP5F1E RB1 SF3B1 ATP5PO MLXIPL BRD4 CLDN1 UBE2L6 PKLR OGDH HMGA1 CLDN4 GRB2 DDX21 SQSTM1 BCL7B BUD23 VPS9D1 LAT2 UBE2E3 VPS37C UBE2E1 VPS37D VPS37A VPS37B FZD9 CLIP2 METTL27 ATF4 HEL-S-162eP FKBP6 VPS28 ATPAF1 TRIM50 HOXC8 UBIAD1 FBLN2 FBLN5 MVB12A EIF4H LIMK1 CLASP2 ABHD11 PRKG1 TMEM270 TBL2 GTF2IRD1 ATP8 H2AX CLDN5 MYO1C CLASP1 HSPA2 HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CARCINOMA PATHWAY%WIKIPATHWAYS_20260510%WP4206%HOMO SAPIENS Hereditary leiomyomatosis and renal cell carcinoma pathway HIF1A PRKAG1 ACACA PRKAA1 VEGFA RPS6 NFE2L2 SLC11A2 ACACB PRKAB1 EGLN1 PDHA2 PDHA1 HEL-S-133P KEAP1 MAMMARY GLAND DEVELOPMENT EMBRYONIC DEVELOPMENT STAGE 1 OF 4%WIKIPATHWAYS_20260510%WP2813%HOMO SAPIENS Mammary gland development embryonic development stage 1 of 4 TNF ITGB1 ERBB4 CLDN4 SFRP1 TERT ALPL TGFB1 NRG3 CCND1 ITGA6 ZEB2 MYC ARACHIDONATE EPOXYGENASE EPOXIDE HYDROLASE%WIKIPATHWAYS_20260510%WP678%HOMO SAPIENS Arachidonate epoxygenase epoxide hydrolase COX8A CYP2J2 EPHX2 COX5A HEL-S-22 CYP2C9 CYP2C8 STATIN INHIBITION OF CHOLESTEROL PRODUCTION%WIKIPATHWAYS_20260510%WP430%HOMO SAPIENS Statin inhibition of cholesterol production APOA2 APOC3 APOE CYP7A1 ABCA1 APOA5 ABCG8 ABCG5 DGAT1 SCARB1 LIPC SOAT1 LPL PDIA2 APOA4 PLTP LDLR ACSS1 MTTP HMGCR APOB SQLE APOC2 FDFT1 APOC1 JAK STAT SIGNALING IN THE REGULATION OF BETA CELLS%WIKIPATHWAYS_20260510%WP5358%HOMO SAPIENS JAK STAT signaling in the regulation of beta cells SOCS2 STAT3 PRL MTOR KRAS CISH CDK4 STAT5B STAT1 RPTOR GHR AKT3 PRLR FOXM1 SOCS1 IFNGR1 MLST8 HRAS EPO IL6R EPOR GH1 IFNG NRAS IL6 SOCS3 AKT1S1 CCND3 IFNGR2 CCND2 FABP4 IN OVARIAN CANCER%WIKIPATHWAYS_20260510%WP4400%HOMO SAPIENS FABP4 in ovarian cancer FABP4 SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP %WIKIPATHWAYS_20260510%WP3391%HOMO SAPIENS Senescence associated secretory phenotype SASP H2AB1 RPS6KA3 CDC27 H2AJ ANAPC7 H3C15 RELA ANAPC5 ANAPC1 ANAPC2 CDKN1A IL1A ANAPC10 MAPK3 ANAPC11 UBE2C UBB IGFBP7 CDK2 CCNA2 JUN FZR1 CDKN2D CDKN2B CDKN2C STAT3 H3F3B H2AC19 CDKN2A UBE2D1 H2AC14 H2BC26 H2BC12L H2BC21 UBC EHMT1 CDK6 HIST1H2AB CDK4 H2AC6 H2BC17 MAPK7 H2BC12 H2BC13 H2AZ1 H2BC14 H2BC15 H4C9 MAPK1 UBE2E1 H2BC11 HIST1H2BE HIST1H4L NFKB1 H2BC9 CEBPB H2BC8 H2BC3 IL6 RPS6KA2 RPS6KA1 RPS27A H2BC1 H2AC20 CDC26 VENTX ANAPC15 C10orf104 UBE2S CXCL8 H2AX CDKN1B CDC23 H2AZ2 H3C8 FOS INTRACELLULAR TRAFFICKING PROTEINS INVOLVED IN CMT NEUROPATHY%WIKIPATHWAYS_20260510%WP4856%HOMO SAPIENS Intracellular trafficking proteins involved in CMT neuropathy RAB3B FIG4 EGR2 KIF1B RABAC1 MPZ RAB11A NEFL LRSAM1 RAB11B RAB4B HSPB8 RAB7A LITAF GDAP1 PMP22 MFN2 FGD4 SH3TC2 RAB25 MTMR2 HEL-S-102 RAB4A SBF2 HEMATOPOIETIC STEM CELL GENE REGULATION BY GABP ALPHA BETA COMPLEX%WIKIPATHWAYS_20260510%WP3657%HOMO SAPIENS Hematopoietic stem cell gene regulation by GABP alpha beta complex TERF2 BCL2 MCL1 EP300 BCL2L1 SMARCA4 GABPA FOXO3A FLT3 ETV6 CREBBP PTEN ZFX ATM DNMT3B SMAD4 GABPB1 PAFAH1B1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5409%HOMO SAPIENS PAFAH1B1 copy number variation TUBA1A NDEL1 RELN NUDC HEL-S-303 VLDLR PAFAH1B1 DYNC1H1 DCX GUT LIVER INDOLE METABOLISM %WIKIPATHWAYS_20260510%WP3627%HOMO SAPIENS Gut liver indole metabolism CYP2E1 METABOLISM OF DICHLOROETHYLENE BY CYP450%WIKIPATHWAYS_20260510%WP3666%HOMO SAPIENS Metabolism of dichloroethylene by CYP450 CYP2E1 GENES ASSOCIATED WITH THE DEVELOPMENT OF RHEUMATOID ARTHRITIS%WIKIPATHWAYS_20260510%WP5033%HOMO SAPIENS Genes associated with the development of rheumatoid arthritis CTLA4 CCR6 CD40 SLC22A4 TRAF1 MHC2TA IL2RA IL6ST FCRL3 PTPN22 HLA-DRB1 PADI4 CD244 PHF19 BLK STAT4 ITGAV NAD BIOSYNTHETIC PATHWAYS%WIKIPATHWAYS_20260510%WP3645%HOMO SAPIENS NAD biosynthetic pathways NMNAT1 IDO1 HEL-S-90n PARP2 SIRT5 TDO2 SIRT1 SIRT2 SIRT3 NAPRT BST1 NAMPT NADSYN1 TNKS PARP4 PARP1 SIRT7 TNKS2 SIRT6 SIRT4 RAC1 PAK1 P38 MMP2 PATHWAY%WIKIPATHWAYS_20260510%WP3303%HOMO SAPIENS RAC1 PAK1 p38 MMP2 pathway TNIP3 YAP1 ANGPT4 MAPK12 MAPK11 RELA MAPK9 MAPK8 MAPK3 STAT5B MAPK14 MYC HRAS ANGPT2 CTNNB1 ANGPT1 SOS1 NCK1 PXN PIK3CA SRC CRK EGFR FOXO1 EIF4EBP1 STAT3 ITGB1 MSH2 NOS2 KRAS GRB2 BIRC5 IKBKB NFKBIA CHUK MAPK1 IKBKG RAC1 MMP2 NFKB1 MAPK13 PIK3R1 NRAS PAK1 BAD GRB14 PTPN11 BAX CASP9 RS1 ANGPTL1 GRB7 ERBB2 RAD51 TNIP2 CARDIAC PROGENITOR DIFFERENTIATION%WIKIPATHWAYS_20260510%WP2406%HOMO SAPIENS Cardiac progenitor differentiation MESP1 THY1 TNNI3 NODAL SOX17 NKX2-5 TBX20 IRX4 MYLK3 TBX5 ISL1 TGFB1 PAX6 MAPK14 CXCR4 KDR IGF2 FGF2 PDGFRA MESP2 SOX2 NOG DKK1 KIT BMP1 SOX1 NRG1 POU5F1 ZFP42 ROR2 MYL2 GATA4 IGF1 MEF2C LIN28A SIRPA NCAM1 INHBA BMP4 FOXA2 SCN5A TBXT WNT3A MIXL1 NOTCH1 LIN28B MYH6 GSK3B INS CLEAR CELL RENAL CELL CARCINOMA PATHWAYS%WIKIPATHWAYS_20260510%WP4018%HOMO SAPIENS Clear cell renal cell carcinoma pathways EP300 KDM5C BAP1 EFCAB3 PBRM1 MAP2K5 SDSL PGBD5 LDHD HK3 ACACA SHMT1 FLT1 PTEN LDHB CREBBP ALDOB RPTOR DEPTOR PGM2 ACACB SSPN KDR MLST8 PLOD2 PDGFRA KSR1 TSC2 TSC1 HIF1A AKT1S1 RAPGEF5 ENO2 EGFR FASN ENO3 HEL-S-32 HK2 ACLY PKLR STAT3 MTOR RHEB PSAT1 PHGDH HEL-S-51e PSPH SQSTM1 BHLHE41 GRB10 HEL-S-87p HEL-S-30 CAMK1 HEL-S-133P ENO1 HEL-S-68p PFKM HEL-S-162eP HEL-S-49 ME1 PFKP VHL ENPP3 KCNJ2 VEGFA PFKL CEP290 SETD2 RETT SYNDROME%WIKIPATHWAYS_20260510%WP4312%HOMO SAPIENS Rett syndrome GABRA3 NCOR1 SYNE2 CDKL5 ACTL6B CHD4 KDM5B TRRAP GPS2 RHOBTB2 CECR2 SMARCA4 HIVEP2 KCNJ10 TBL1XR1 GNAO1 IMPDH2 GABBR2 BRAF SCN1A SRRM3 STXBP1 SCN8A SCN2A HDAC5 TAF1B HDAC8 TBL1X TCF4 EIF2B2 SMC1A SMARCA1 FOXG1 XAB2 HAP1 SYNGAP1 NCOR2 HTT HDAC1 GRIN2B CRK SHANK3 MEF2C PURINE METABOLISM%WIKIPATHWAYS_20260510%WP4792%HOMO SAPIENS Purine metabolism ADSL AMPD1 XDH PNP APRT DGUOK ADA IMPDH1 HPRT1 ADSS HEL-S-70p COVID 19 STRUCTURAL COVERAGE MAP%WIKIPATHWAYS_20260510%WP5145%HOMO SAPIENS COVID 19 structural coverage map MACROH2A2 MACROH2A1 ACE2 NRP1 SLC6A19 UBC NLRP12 UPF2 PARP14 IGHMBP2 UBB GDAP2 MACROD1 HEL97 MACROD2 CMTR1 AQR PAIP1 TOMM70 MAP3K7IP1 PALS1 ISG15 EUKARYOTIC TRANSCRIPTION INITIATION%WIKIPATHWAYS_20260510%WP405%HOMO SAPIENS Eukaryotic transcription initiation POLR2B POLR2G POLR2I POLR2J GTF2H2C_2 GTF2H2 GTF2H3 TAF9 POLR1A GTF2E2 POLR3B POLR1D HEL-S-28 POLR3D ERCC2 POLR3E POLR2C MNAT1 TBP TAF7 POLR3K TAF6 GTF2E1 POLR2F CDK7 POLR2H POLR2K POLR3H TAF12 TAF13 GTF2F2 CCNH TAF5 GTF2B POLR2A IMATINIB AND CHRONIC MYELOID LEUKEMIA%WIKIPATHWAYS_20260510%WP3640%HOMO SAPIENS Imatinib and chronic myeloid leukemia PDGFRA SKP2 GAB2 ABCB1 KIT GADD45A FLT1 FOXO3A CSF1R PIM1 CDKN1B PIM2 BCR LYL1 ABCG2 MYC NOP2 TRANSLATION FACTORS%WIKIPATHWAYS_20260510%WP107%HOMO SAPIENS Translation factors EIF3CL EIF4B EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B EIF2S2 EEF2 EIF2S1 EIF6 EIF4A2 EIF4G1 PAIP1 GSPT2 EEF1B2 EIF4EBP3 EIF2B3 CLUH EIF1AY EEF1G EEF1A2 ETF1 EIF2B5 EIF4H EIF2B2 EEF2K EIF5A EEF1A1 PABPC1 EIF4E EIF5B EIF1AX SUI1 EIF2AK2 EIF5 EIF4A1 EIF2AK1 EIF2S3 EIF2B1 EIF3S2 EIF4EBP1 EIF3J EIF4EBP2 EIF3S3 EIF3G DRUG INDUCTION OF BILE ACID PATHWAY%WIKIPATHWAYS_20260510%WP2289%HOMO SAPIENS Drug induction of bile acid pathway CYP7A1 ABCC3 ABCC2 ABCB1 CYP3A4 SLC51A BAAT SLC51B ABCB11 SLCO1B1 NR1H4 SULT2A1 NR1i2 NR1I3 NR1i1 GLIAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260510%WP2276%HOMO SAPIENS Glial cell differentiation CNP FREP1 HEL70 MBP GAP43 CALCIUM MEDIATED T CELL APOPTOSIS INVOLVED IN INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260510%WP5142%HOMO SAPIENS Calcium mediated T cell apoptosis involved in inclusion body myositis CD8B1 ZAP70 NFATC2 CALM1 CD8A EP300 LCK ITPRIP ATP2A1 CABIN1 PLCG1 MEF2D HDAC2 HDAC1 PPP3CC PPP3CA AMPLIFICATION AND EXPANSION OF ONCOGENIC PATHWAYS AS METASTATIC TRAITS%WIKIPATHWAYS_20260510%WP3678%HOMO SAPIENS Amplification and expansion of oncogenic pathways as metastatic traits VEGFA TCF7L2 POSTN VCAM1 SRC TCF7L1 LEF1 TNC CYTIP CXCR4 VHL NOTCH1 ACQUIRED PARTIAL LIPODYSTROPHY BARRAQUER SIMONS SYNDROME%WIKIPATHWAYS_20260510%WP5104%HOMO SAPIENS Acquired partial lipodystrophy Barraquer Simons syndrome FNTA ICMT CFD LMNA RCE1 HEL-S-62p LMNB2 ALLOGRAFT REJECTION%WIKIPATHWAYS_20260510%WP2328%HOMO SAPIENS Allograft rejection CXCL13 CASP8 PRKCZ TNFSF6 C4B_2 CSNK2A2 C2 IL13 IL12B IL10 IL1A C6 C7 IF2B1 BHMT2 C9 IL12A TGFB1 HLA-G CD55 STAT1 CD40LG HEL113 HEL-S-62p HLA-DRA IL-21 IL2 FAS FOXP3 C1QC PDGFRA IFNG TUBA1B HLA-DMB CXCL11 CXCL12 GNLY HLA-DOA HLA-DOB HLA-DMA ABCB1 IL4 IL2RA HLA-DQA2 HLA-DQA1 PECR IL17A HLA-A HLA-DRB5 GDNF HLA-DRB1 LRRK2 HLA-DPA1 HLA-DQB1 CTLA4 HLA-DPB1 HLA-B HLA-C HLA-F GABPA HLA-E CXCR5 IL1B CCL19 CXCL9 HARS1 CCL21 PRF1 AGTR1 C8A C4A TNF CD40 CXCL8 C1QA VEGFA CASP9 MICA CD80 CASP3 C1QB IL5 PHOTODYNAMIC THERAPY INDUCED UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260510%WP3613%HOMO SAPIENS Photodynamic therapy induced unfolded protein response ASNS HEL-S-99n DNAJB11 EIF2A ATF3 PPP1R15A BBC3 SULT1E1 BCL2L11 EDEM1 NARS1 DNAJC3 ERP27 DNAJB9 HEL-S-125m HEL-S-89n NFE2L2 DDIT3 UBE2E1 XBP1 TRIB3 ATF4 ERN1 ENVELOPE PROTEINS AND THEIR POTENTIAL ROLES IN EDMD PHYSIOPATHOLOGY%WIKIPATHWAYS_20260510%WP4535%HOMO SAPIENS Envelope proteins and their potential roles in EDMD physiopathology ADCY6 SYNE2 SYNE1 BANF1 KRAS GRB2 MAPK3 TGFB1 MAPK1 SMAD2 SMAD4 ARHA HRAS LBR WWTR1 LEMD3 MAP2K2 NRAS CTGF SYNE4 SYNE3 SOS1 SUN1 SOS2 YY1AP1 PLEC HEL-S-7a HEL-S-15 EMD HEL-S-61 ADCY9 MAP2K1 ADCY3 TMEM43 ADCY1 ADCY8 MONOAMINE TRANSPORT AND REGULATION%WIKIPATHWAYS_20260510%WP727%HOMO SAPIENS Monoamine transport and regulation TPH2 TDO2 FBXO32 IL1R1 SYN1 SLC5A7 IL1B AMPH DBH SLC6A1 MAPK14 STX1A TNFRSF11B SLC6A3 TNF SLC6A2 TSC2 TH RBL2 ACHE HRH3 ADORA2A NECTIN2 TGFB1I1 UNC13B ITGB3 IL2 SIGNALING%WIKIPATHWAYS_20260510%WP49%HOMO SAPIENS IL2 signaling STAT3 FYN GAB2 IL2RG JAK3 GRB2 FOXO3A CISH MAPK3 JAK1 STAT5B SYK PTK2B STAT1 RPS6 RPS6KB1 RPS6KB2 MAPK1 IL2 RAF1 HRAS MAP2K2 PIK3R1 LCK SOCS3 IL2RB CRKL PTPN11 SOS1 IL2RA SHC1 NMI MAP2K1 CBL IL11 SIGNALING%WIKIPATHWAYS_20260510%WP2332%HOMO SAPIENS IL11 signaling CREB1 STAT3 FYN YES1 RELA GRB2 PTPA RUNX2 ATF1 BIRC5 MAPK3 JAK1 IKBKB TGFB1 STAT1 CHUK RPS6 RPS6KB1 IL6ST IL11 MAPK1 IL11RA RAF1 ITGA2 TYK2 HRAS MAP2K2 BCL2 PIK3R2 PIK3R1 BGLAP IBSP RPS6KA1 SOCS3 PTPN11 PDPK1 SRC MAP2K1 PIAS1 FES INTRAFLAGELLAR TRANSPORT PROTEINS BINDING TO DYNEIN%WIKIPATHWAYS_20260510%WP4532%HOMO SAPIENS Intraflagellar transport proteins binding to dynein DYNLL2 IFT22 IFT27 DYNLT2B DYNLRB2 DYNC1LI1 DYNC2LI1 DNCL1 DYNC2H1 DYNC1I1 IFT25 DYNLT1 IFT140 DYNC1LI2 IFT80 DYNC2I2 WDR35 IFT43 IFT81 DYNC1H1 DYNLT3 IFT46 REGUCALCIN IN PROXIMAL TUBULE EPITHELIAL KIDNEY CELLS%WIKIPATHWAYS_20260510%WP4838%HOMO SAPIENS Regucalcin in proximal tubule epithelial kidney cells APAF1 MTOR CASP8 PTH TRPV5 TGFB1 BRAF MAPK1 SMAD2 SMAD4 RAF1 PDE1B TGFBR1 PPP3R1 TNFSF11 BAK1 BAX CALCA PIK3CA CASP9 MCU FFAR3 SEC16B HEL-S-41 CASP3 MAP3K5 TNFRSF1A ACTA2 MSMP EXPRESSION REGULATION IN CANCER CELLS AND ITS PRO ANGIOGENIC ROLE IN OVARIAN TUMORS%WIKIPATHWAYS_20260510%WP4397%HOMO SAPIENS MSMP expression regulation in cancer cells and its pro angiogenic role in ovarian tumors CTCF MSMP CCR2 NEUROINFLAMMATION%WIKIPATHWAYS_20260510%WP4919%HOMO SAPIENS Neuroinflammation JUN NFKBIA TLR4 MTOR CHUK RELA ASCC1 MAPK14 NOS2 COX2 MAPK8 FOS INHIBITION OF EXOSOME BIOGENESIS AND SECRETION BY MANUMYCIN A IN CRPC CELLS%WIKIPATHWAYS_20260510%WP4301%HOMO SAPIENS Inhibition of exosome biogenesis and secretion by manumycin A in CRPC cells RAB5B RAB5C NRAS HNRNPH1 KRAS HGS MAPK3 RRAS2 RAB5A ARAF RRAS BRAF PDCD6IP MAPK1 RAF1 RAB27A HRAS MAJOR RECEPTORS TARGETED BY EPINEPHRINE AND NOREPINEPHRINE%WIKIPATHWAYS_20260510%WP4589%HOMO SAPIENS Major receptors targeted by epinephrine and norepinephrine ADRA2A HEL-S-7a ADCY6 ADRA1D ADRB1 ADRB2 ADCY9 ADCY3 ADRA2C ADCY1 ADCY8 ADRA2B 2Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP5221%HOMO SAPIENS 2q11 2 copy number variation syndrome FER1L5 STARD7 SEMA4C ARID5A ASTL NEURL3 SNRNP200 KANSL3 PLXNB2 MMS19 MAPK3 CIAO2B MAPK1 DUSP2 ARHA ADRA2B ANKRD23 ZP2 COX11 COL2A1 CIAO2A ANKRD39 PARL CIAO1 ITPRIPL1 TMEM127 CNNM3 ERBB2 CNNM4 GLUCOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260510%WP5280%HOMO SAPIENS Glucocorticoid biosynthesis HSD11B1 AKR1C4 HSD11B2 CYP21A2 SRD5A2 AKR1C1 CYP11B2 CYP3A4 AKR1C2 AKR1D1 ANTIVIRAL AND ANTI INFLAMMATORY EFFECTS OF NRF2 ON SARS COV 2 PATHWAY%WIKIPATHWAYS_20260510%WP5113%HOMO SAPIENS Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway IRF3 RELA SLC7A11 HMOX1 GUCY1A2 IL12A IKBKB IL1B NFKBIA CHUK NQO1 IKBKG GUCY1B1 NFKB1 KEAP1 CCL2 TNF ACE2 RXRA IL6 CXCL8 NFE2L2 GCLC GCLM TMPRSS2 MMP3 PHASE I BIOTRANSFORMATIONS NON P450%WIKIPATHWAYS_20260510%WP136%HOMO SAPIENS Phase I biotransformations non P450 PON1 CES2 CES1 PON3 ESD LIPA PON2 HEL126 NONALCOHOLIC FATTY LIVER DISEASE%WIKIPATHWAYS_20260510%WP4396%HOMO SAPIENS Nonalcoholic fatty liver disease PRKAA2 NDUFA11 RELA COXFA4L2 NDUFC2 MAPK9 NDUFC1 MAPK8 NDUFS8 IL1A NDUFS6 NDUFS5 SDHB NDUFS4 NDUFS3 TGFB1 NDUFS1 NDUFB8 NDUFB7 NDUFB10 NDUFB6 NDUFB5 NDUFB4 NDUFB11 NDUFB2 NDUFB1 NDUFV3 NDUFV2 NDUFA9 NDUFA7 NDUFA6 NDUFA5 JUN PIK3CA NDUFA3 NDUFA2 NDUFAB1 MLXIPL SDHA SDHC UQCRB SDHD MAP3K11 UQCR11 UQCR10 NDUFC2-KCTD14 CYB COX6B2 UQCRH COX7B2 UQCRQ MLX UQCRC1 COX8C CYC1 MLXIP UQCRC2 UQCRHL IKBKB NFKB1 CDC42 TRAF2 NDUFA10 NDUFA13 IRS1 TNFRSF1A NR1H4 XBP1 INS COX4I2 BBC3 CASP8 BCL2L11 TNFSF6 GSK3A PIK3CD AKT3 FAS CYCS NR1H3 NR1C1 IL6R CCL2 VCAM1 RXRA SOCS3 ITCH DDIT3 NDUFB9 INSR PKLR EIF2S1 UQCRFS1 COX7A1 IL1B PRKAB2 PRKAB1 RAC1 CYP2E1 ATF4 LEP CEBPA COX7B PIK3R3 TNF PIK3R2 PIK3R1 COX4I1 COX7A2 IL6 ADIPOR2 COX6A1 NDUFA12 PRKAG1 COX7C COX6A2 ADIPOR1 PRKAG2 COX5A BAK1 COX3 PRKAG3 PRKAA1 COX7A2L COX2 NDUFB3 GSK3B CXCL8 COX8A ZNF183 BAX COX6B1 CASP3 MAP3K5 COXFA4 LEPR ERN1 GPCRS CLASS A RHODOPSIN LIKE%WIKIPATHWAYS_20260510%WP455%HOMO SAPIENS GPCRs class A rhodopsin like F2R FPR2 HRH3 GPER LTB4R KPG_011 CCR10 CCR1 XCR1 FPR1 CCR8 CCR7 CCR6 CCR4 CCR2 BDKRB2 SSTR2 CXCR5 BDKRB1 NPFFR2 RRH GPR174 GPR161 GPR173 GPR171 CMKLR2 GPR37L1 OR1I1 NPBWR2 OR6B1 OR2J3 OR2J2 OR2J1 RGL4 OR6A2 OXTR OR7C2 OR7C1 NPY2R GPR19 OR10J1 GPR27 NPFFR1 GPR25 GPR22 GPR39 DRD1 OR5F1 DRD2 GPR34 DRD3 PTGDR GPR31 OPRK1 GPR32 OR5V1 OR3A2 OR10H1 OR10H3 GPR45 MGRA HCRTR2 OR10H2 HCRTR1 GPR42 OR2AG1 ADORA2A CHML MTNR1B GPR52 GPR4 GPR3 GPR6 OR1C1 GPR65 GPR63 OR2D2 OR2T1 OR1A2 OR1A1 OR2C1 SUCNR1 OR5I1 MCHR1 OR2S2 HCAR3 OR1Q1 GPR83 HCAR1 OR2B3 OR2B2 NMUR2 NMUR1 F2RL1 OR7A10 OR14J1 MLNR AVPR2 PRLHR OR8D2 OR7A17 OR7A5 CCR5 OR10A4 OR1E2 OR8B8 OR2W1 HTR2B OR12D3 HTR4 OR1D5 HRH1 OR1D2 HTR6 CXCR4 OR2F2 HTR7 GPR85 ACKR2 HRH2 OR11A1 FFAR1 DRD5 ADRA2C CXCR3 HTR5A ADRA2B ADRA2A ACKR3 MC1R GPR87 GPR75 GPR37 MAS1L CXCR1 GPR68 OPN1SW OPN1MW OPN1LW OPN4 OPN3 RHO MC3R NMBR GHSR EDNRA EDNRB HTR2A HTR1E HTR1F F2RL2 HTR1D HTR1B 5HT1A CNR1 LHCGR P2RY10 P2RY14 NPY1R OR1G1 KPG_010 GRPR P2RY6 P2RY4 ADORA2B P2RY2 CCR3 OR1F1 OR2H1 CCKBR FSHR CCRL2 OR3A3 OR10A5 OR3A1 OR1E1 OR2B6 NTSR1 LPAR4 P2RY13 GPR17 P2RY11 CHRM2 OR2F1 CHRM3 CHRM1 C3AR1 CHRM4 CHRM5 OR2A4 GPR18 CMKLR1 IL8RB F2RL3 MC4R ACKR4 CX3CR1 C5AR2 PTGDR2 ADRB1 ADRB2 GPR15 P2RY1 DRD4 ADRA1D ADRA1B ADRA1A AVPR1B ADRB3 AGTR1 AGTR2 BRS3 CCKAR NPY5R OPRM1 AVPR1A SSTR3 SSTR4 FPRL2 TRHR SSTR5 OPRD1 NPY4R MC2R PTGER4 PTGFR GALR3 GALR2 PTGIR GALR1 PTGER1 PTGER2 NTSR2 PTGER3 MC5R GPR50 MTNR1A FFAR3 CNR2 FFAR2 TBXA2R