HALLMARK_P53_PATHWAY%MSIGDBHALLMARK%HALLMARK_P53_PATHWAY HALLMARK_P53_PATHWAY CYFIP2 RB1 APP CCNK STEAP3 CD82 HEL-S-130P CD81 DGKA RNF19B CCP110 ABAT TM7SF3 IFI30 RRP8 CCND3 CCND2 SESN1 RPL36 FDXR FOXO3A NUDT15 IER5 TP63 PHLDA3 RPS12 TSPYL2 TNLG5A FBXW7 F2R DNTTIP2 IRAG2 TRAFD1 TAP1 CGRRF1 PRKAB1 TM4SF1 PROCR MAPKAPK3 DDIT3 DDIT4 NINJ1 TXNIP S100A4 TRIB3 NUPR1 ANKRA2 ISCU ATF3 EPHA2 POM121 NOTCH1 ABHD4 RETSAT SLC35D1 RRAD AK1 HSPA4L TGFA PDGFA XPC KLK8 CDKN2AIP LDHB NHLH2 SOCS1 IRAK1 ZMAT3 CLCA2 HMOX1 SFN IP6K2 SLC19A2 S100A10 HEXIM1 JAG2 PLK3 JUN ST14 TGFB1 PMM1 GADD45A FUCA1 PLK2 ZBTB16 EPHX1 OSGIN1 LIF INHBB ALOX15B H1-2 PTPRE BMP2 H2AC25 TCN2 SP1 MDM2 SDC1 PLXNB2 MXD1 FGF13 ADA MXD4 RAD9A CSRNP2 BTG2 CDKN1A BTG1 ITGB4 TCHH IKBKAP TRIAP1 SLC7A11 PITPNC1 PIDD1 SEC61A1 HINT1 GM2A KIF13B CTSF WDR8 HRAS ZNF365 GPX2 APAF1 PRMT2 ABCC5 SPHK1 DCXR RHBDF2 VWA5A AEN FOS SERPINB5 DDB2 VAMP8 IL1A H2AJ RAP2B RAD51C TRAF4 TAX1BP3 HBEGF PPP1R15A CEBPA HDAC3 PCNA GLS2 RGS16 EI24 NOL8 RPS27L SLC3A2 ACVR1B RCHY1 PPM1D TOB1 SERTAD3 DRAM1 RXRA RAB40C PERP TNNI1 STOM EPS8L2 BAK1 RPL18 CDKN2B NR1i1 CDKN2A TPRKB WWP1 BAIAP2 KLF4 TPD52L1 BLCAP DEF6 CCNG1 BAX FAS ERCC5 COQ8A CDK5R1 HALLMARK_MITOTIC_SPINDLE%MSIGDBHALLMARK%HALLMARK_MITOTIC_SPINDLE HALLMARK_MITOTIC_SPINDLE HCTP4 CCNB2 RHOT2 BCL2L11 KIF3B CEP72 STK38L CEP192 KIF3C ECT2 MARK4 MYH10 SPTBN1 SAC3D1 PLK1 TBCD ARHGAP29 ARHGAP27 HOOK3 SSH2 CDC2 NET1 NF1 SASS6 TUBGCP5 TUBGCP6 CNTROB MAP3K11 CEP57 TOP2A DOCK4 NUMA1 KIF11 WASL ARHGAP5 BRCA2 KIF15 ARHGAP4 SEPT9 PCM1 CAPZB CNTRL NCK2 TLK1 KIF1B SPTAN1 DLGAP5 NCK1 ARHGEF11 PLEKHG2 ARHGEF12 DST RFC1 SHROOM2 KIF23 SHROOM1 RHOF SMC1A CKAP5 DYNLL2 LATS1 ARHGAP10 ESPL1 INCENP PALLD CDC42EP4 RASA2 ARHGEF3 CDC42EP2 CDC42EP1 MYH9 BIRC5 ARHGEF2 ARHGEF7 MAPRE1 RAPGEF5 SOS1 DOCK2 RAPGEF6 PAFAH1B1 ARF6 KNS2 STAU1 ROCK1 KATNB1 TUBD1 NEDD9 TTK HDAC6 AURKA HEL-S-47e CDC42 CYTH2 FGD4 FGD6 KATNA1 FLNA RICTOR FLNB PCNT WASF1 WASF2 CLASP1 ARFGEF1 DYNC1H1 FARP1 PCGF5 MID1IP1 RANBP9 MYO9B CDC42BPA LRPPRC MYO1E CENPE MARCKS CENPF APC PRC1 ALMS1 TAOK2 RAB3GAP1 HEL2 TRIO HEL114 SMC3 SMC4 UXT PREX1 PPP4R2 OPHN1 CDC27 NUSAP1 CEP250 NEK2 KNTC1 FBXO5 KIFAP3 SYNPO CDK5RAP2 HEL-S-61 RALBP1 KNTC2 MAP1S CEP131 CSNK1D TSC1 ACTN4 MID1 TUBA4A CD2AP BCR CLIP2 TIAM1 BIN1 KIF20B EZR ARL8A LLGL1 NOTCH2 PIF1 CPAP PXN HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION%MSIGDBHALLMARK%HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION NT5E ABI3BP GPC1 SPP1 SPOCK1 CD59 SLIT3 SLIT2 MSX1 PDLIM4 CAP2 CTHRC1 PRRX1 VEGFC VEGFA MFAP5 COL3A1 FAP MGP PMP22 PTX3 CRLF1 SNTB1 DST FLNA JUN TGFB1 GADD45A FUCA1 OXTR COL16A1 SPARC SERPINE2 WIPF1 COL12A1 TNC HEL113 PLOD3 SDC1 PLOD2 PLOD1 HEL-S-273 ENO2 FGF2 LOXL1 CTGF LOXL2 MYLK COMP CDH6 RGS4 DKFZp686P11128 GJA1 CDH2 BASP1 DPYSL3 PRSS2 POSTN IGFBP4 APLP1 IGFBP2 TPM1 P3H1 PCOLCE HEL-S-66 DKK1 GEM SFRP4 SFRP1 LOX COL4A2 COL4A1 ADAM12 COL8A2 PPIB MXRA5 SCG2 PFN2 FBN2 COPA NNMT SDC4 NTM HTRA1 TNFRSF11B THY1 FBLN2 NID2 FBLN5 CALD1 QSCN6 VCAM1 CADM1 MAGEE1 GADD45B BDNF TFPI2 FZD8 INHBA COL1A1 IL6 BMP1 COL1A2 CXCL12 SLC6A8 COL5A3 ID2 COL5A2 CALU SNAI2 TGFBI FERMT2 FBN1 ITGB1 CXCL6 CXCL8 ECM2 ITGB5 MCM7 ITGB3 TNFAIP3 FAS LAMC2 CXCL1 LAMC1 AREG CYR61 GLIPR1 SGCD SGCB TIMP3 ITGAV HEL-S-108 TIMP1 COLGALT1 EDIL3 SGCG TNFRSF12A IL15 ITGA2 MMP2 MMP3 PLAUR GPX7 EMP3 DCN RHOB ACTA2 GREM1 TGFBR3 VCAN MMP14 CDH11 TMEPAI GAS1 MATN3 CD44 FOXC2 PCOLCE2 LAMA1 LAMA3 THBS2 NOTCH2 THBS1 FSTL1 PTHLH FSTL3 HALLMARK_PI3K_AKT_MTOR_SIGNALING%MSIGDBHALLMARK%HALLMARK_PI3K_AKT_MTOR_SIGNALING HALLMARK_PI3K_AKT_MTOR_SIGNALING CDKN1A CDC2 ATF1 HEL-S-71 GSK3B HRAS ARF1 CDKN1B CLTC UBE2D3 PRKAG1 PTEN SLA ECSIT HEL-S-125m GNGT1 RPTOR RPS6KA3 TBK1 PPP2R1B RPS6KA1 HEL-S-1 RAC1 MAP3K7 AP2M1 VAV3 MAP2K3 NCK1 ACTR3 ACTR2 PLA2G12A DUSP3 PRKCB TSC2 TRAF2 FGF7B IRAK4 NGF TNFRSF1A LCK AKT1S1 CSNK2B PLCB1 PFN1 RAF1 SQSTM1 PRKAA2 RALB CAB39 MAPKAP1 ITPR2 CXCR4 DDIT3 PIK3R3 DAPP1 NOD1 FGF6B IL2RG TRIB3 HEL-S-99n EGFR ACACA HEL-S-15 GNA14 MAPK9 MAPK8 ADRBK1 MAPK1 RIPK1 PLCG1 EIF4E FGF22 MAP2K6 HEL-S-47e PAK4 SMAD2 STAT2 PTPN11 MAPK10 IL4 PIKFYVE RIT1 TNFSF6 ARPC3 CDK4 CAMK4 SFN CDK2 PIN1 GRB2 MYD88 NFKBIB TIAM1 HALLMARK_GLYCOLYSIS%MSIGDBHALLMARK%HALLMARK_GLYCOLYSIS HALLMARK_GLYCOLYSIS NT5E PSMC4 CTH GPC1 AGRN POLR3K PFKP VEGFA CDC2 CXCR4 DDIT4 EGFR AURKA TGFA ERO1A HEL-S-278 CHPF HEL-S-75 ZNF292 XYLT2 ENO1 HS6ST2 HEL-S-89n DPYSL4 CAPN5 NDST3 PDK3 SOX9 SLC16A3 IL13RA1 RARS1 HEL-S-304 GLCE COG2 SDHC ALG1 MIF SDC1 PLOD2 PHKA2 PLOD1 SAP30 TPST1 ENO2 CLDN3 CLDN9 RRAGD PKP2 KDELR3 RBCK1 KIF20A FKBP4 ALDH7A1 DSC2 GNE COPB2 PFKFB1 PAXIP1 ABCB6 GPR87 SDC2 SDC3 STC1 AK3 AK4 TXN HMMR ARPP19 CACNA1H FUT8 CHST12 STC2 RAA1 NDUFV3 ANKZF1 LHPP HOMER1 HEL-S-165mP ECD GFPT1 GOT2 SRD5A3 HEL-S-133P B3GALT6 EXT1 ISG20 EXT2 EFNA3 GCLC P4HA1 NASP ARTN QSCN6 P4HA2 HEL20 GALK2 LHX9 PYGB B4GALT1 HEL-S-32 CITED2 HEL-S-30 PYGL VLDLR HK2 HS2ST1 HEL-S-69p GMPPB GYS2 GYS1 NANP CASP6 ME1 TGFBI PGM2 ME2 SLC37A4 GUSB MIOX CHST6 CHPF2 PGAM1 PGAM2 HEL-S-68p HEL-S-26 HEL-S-19 HAX1 MED24 ELF3 ADORA2B B3GNT3 TFF3 DEPDC1 CHST1 SLC25A10 ANGPTL4 ALDOB CHST4 LCT DLD MET B4GALT4 FBP2 SLC25A13 ALDH9A1 HEL-S-87p IDUA RPE DCN GLRX NOL3 CENPA CLN6 MXI1 VCAN GPC3 GPC4 EGLN3 SLC35A3 B3GAT3 MDH2 CD44 BIK AGL TPBG B3GAT1 SPAG4 HEL-S-44 MERTK HEL-S-49 GNPDA1 PC HALLMARK_WNT_BETA_CATENIN_SIGNALING%MSIGDBHALLMARK%HALLMARK_WNT_BETA_CATENIN_SIGNALING HALLMARK_WNT_BETA_CATENIN_SIGNALING HDAC5 HDAC2 MAML1 HDAC11 LEF1 PSEN2 RBPJ NR1C2 NKD1 GNAI1 FRAT1 MYC HEY2 DVL2 NOTCH1 SKP2 WNT1 FZD1 WNT5B PTCH1 AXIN1 AXIN2 CSNK1E DKK4 DKK1 NCOR2 ADAM17 KAT2A NUMB CTNNB1 JAG2 CCND2 FZD8 HALLMARK_SPERMATOGENESIS%MSIGDBHALLMARK%HALLMARK_SPERMATOGENESIS HALLMARK_SPERMATOGENESIS CCNB2 CDC2 CLPB CHRM4 GFI1 ACRBP CCT6B TEKT2 PAPOLB IL13RA2 AGFG1 TLE4 PRM2 CSNK2A2 PIAS2 ZPBP ADAM2 ZC2HC1C MTNR1A SCG5 VDAC3 SCG3 HOXB1 STAM2 TSSK2 CFTR DPEP3 DDX4 ALOX15 ART3 OAZ3 FLJ13057 PGS1 PCSK1N NPHP1 IP6K1 ZC3H14 RPL39L GSTM3 PDHA2 ODF1 BRAF HSPA2 SNAP91 H1-6 TUBA2 RAD17 PSMG1 NF2 CNIH2 SPMAP2 EZH2 SYCP1 MAST2 HEL-S-34 IDE COIL TTK SHE HSPA4L HEL162 AURKA GRM8 GSG1 TOPBP1 NEFH HBZ PACRG RFC4 NPY5R DCC PARP2 ELOVL3 SIRT1 CAMK4 MLF1 TSN ARL4A DBF4 MEP1B DMC1 HEL-S-278 ACRV1 TULP2 CST8 AKAP4 ZNRF4 PHKG2 TNNI3 JAM3 CLVS1 SLC12A2 DMRT1 GAD1 NAA11 SEPTIN4 HTR5A CHFR MTOR POMC TNP2 LPIN1 TNP1 CDKN3 ACKR5 NEK2 HALLMARK_APOPTOSIS%MSIGDBHALLMARK%HALLMARK_APOPTOSIS HALLMARK_APOPTOSIS CTH RHOT2 BCL2L11 LEF1 PSEN2 CDKN1B TOP2A CTNNB1 APP SPTAN1 CCND2 FDXR F2R SQSTM1 TAP1 DDIT3 TXNIP ATF3 ROCK1 RETSAT NEDD9 NEFH TNFSF6 HMOX1 CDK2 JUN GADD45A BMP2 IFITM3 PRF1 PLAT ENO2 CLU TNF CCND1 TNFSF10 BTG2 BNIP3L CDKN1A HGF CDC25B EREG FEZ1 MADD DAP3 DIABLO PSEN1 BCL10 EBP PPP3R1 BCL2L10 ANKH PMAIP1 BMF CD14 IGFBP6 MCL1 CREBBP GSTM1 H1-0 IGF2R CYLD DAP PPT1 BCL2L2 BCL2L1 BTG3 HMGB2 BRCA1 IL1A CASP9 CASP8 CASP3 CASP4 CASP2 ISG20 PBR HEL-S-102 DFFA GPX1 ANXA1 GPX4 GPX3 IFNGR1 IL18 PPP2R5B EMP1 GADD45B AVPR1A F2 DNAJC3 HEL-75 IRF1 IL1B IL6 DPYD RARA ETF1 PLCB2 BIRC3 RNASEL GUCY2D SATB1 CASP6 SLC20A1 PLPPR4 RELA ADD1 GNA15 PAK1 ERBB3 ERBB2 LMNA SC5D BCAP31 IFNB1 BAX MGMT FAS CD2 WEE1 KRT18 CD69 TIMP3 TIMP1 TNFRSF12A MMP2 DCN RHOB TGFBR3 CD44 BIK HEL-S-44 HALLMARK_COMPLEMENT%MSIGDBHALLMARK%HALLMARK_COMPLEMENT HALLMARK_COMPLEMENT MAFF GNB4 CALM1 CPM SERPINA1 DYRK2 CD59 ITGAM CPQ DOCK9 PLEK PCSK9 CTSS CTSO AKAP10 GNGT2 PCLO CASP5 CASP10 CTSL KYNU CTSH KLNA1 OLR1 CD36 HEL-S-7 CTSC DUSP5 CR2 SERPINB2 CR1 DOCK4 FCER1G GP1BA APOA4 SIRT6 F3 ADRA2B F5 MMP12 HEL-S-130P HEL-76 F7 F8 PLSCR1 PIK3CA MMP15 IRF2 IRF7 LCP2 CD46 L3MBTL4 C1QA USP14 CEBPB SCG3 USP15 USP16 C1S C1R SERPINC1 TMPRSS6 LCK SRC WAS GNAI3 PLG PFN1 PRCP RAF1 RNF4 PPM2C GNG2 SPOCK2 CCL5 FYN SH2B3 CD55 F10 GCA HEL-S-62p KCNIP3 GZMA ATOX1 ARHG GZMK CD40LG XPNPEP1 APOC1 KLKB1 C1QC MSRB1 GRB2 HEL-S-89n PLAT CLU PSEN1 COL4A2 RAA1 CASP9 CASP3 CASP4 F2 TFPI2 IRF1 IL6 ME1 TNFAIP3 CXCL1 CDK5R1 DGKG FCN1 CDA GMFB C4BPB LIPA NR2A1 DOCK10 TIMP1 LAMP2 PIM1 ACTN2 HPCAL4 GPD2 FDX1 ADAM9 SERPING1 LAP3 PLAUR S100A9 CFH GATA3 PLA2G7 PIK3R5 C2 DPP4 VCPIP1 PPP4C MMP14 C9 S100A13 S100A12 RCE1 STX4A LYN APOBEC3F APOBEC3G BRPF3 CP MT3 EHD1 GP9 GNB2 HALLMARK_E2F_TARGETS%MSIGDBHALLMARK%HALLMARK_E2F_TARGETS HALLMARK_E2F_TARGETS CCNB2 PLK1 MYC CDC2 CDKN1B TOP2A BRCA2 CCP110 DLGAP5 RFC1 SMC1A ESPL1 BIRC5 EZH2 DCLRE1B JPT1 NUP107 POP7 TFRC AURKA DSCC1 BUB1B SMC6 MKI67 CDC20 PNN PTTG1 WDR90 CHEK2 CHEK1 NBN CDK4 LIG1 HUS1 ILF3 DDX39A MSH2 CCNE1 MTHFD2 ZW10 TIMELESS ASF1A ASF1B SNRPB SLBP CENPE NUP205 RNASEH2A CDCA3 PRKDC SHMT1 AK2 CDCA8 NOLC1 PDS5B RAD51AP1 ORC6 UBR7 RAD21 ORC2 LYAR BARD1 CDKN3 PLK4 HEL25 HMGA1 NUP153 PA2G4 EIF2S1 PAICS PAN2 POLA2 CDKN1A STAG1 CDC25B KIF18B UBE2S UBE2T ANP32E HNRNPD MXD3 H2AX HEL-S-97n SUV39H1 HMGB3 PSIP1 CTCF CKS1B CROP ING3 HMMR MYBL2 TK1 LBR POLE TCF19 HELLS RFC3 RFC2 EED TUBB CTPS1 TUBG1 HMGB2 CIT BRCA1 MMS22L CKS2 MCM3 RAD51C MCM5 NAA38 MCM6 DCTPP1 MCM2 PRIM2 AURKB PCNA UNG NASP POLD3 PSMC3IP TRA2B EXOSC8 POLD2 PPP1R8 USP1 PMS2 PPM1D RBBP7 E2F8 GINS1 H2AZ1 NOP56 RANBP1 DUT CDKN2C RRM2 SPAG5 GINS3 ATAD2 GINS4 DONSON CDKN2A RPA1 MRE11A SSRP1 DEK POLE4 NUDT21 RAD50 PHF5A MCM7 RPA3 BRMS1L RQCD1 TACC3 WEE1 CENPM RAD1 TRIP13 RAN SPC24 SMC3 MAD2L1 SMC4 DEPDC1 SPC25 HALLMARK_G2M_CHECKPOINT%MSIGDBHALLMARK%HALLMARK_G2M_CHECKPOINT HALLMARK_G2M_CHECKPOINT HCTP4 TNPO2 CCNB2 SS18 RBM14 HEL-S-72p HEL164 H2BC12 CCNA2 SLC7A5 SFPQ RBL1 TFDP1 DTYMK DKFZp666G145 SLC7A1 PLK1 HIRA PURA MYC WRN CDC45 NSD2 E2F2 CDC2 DMD E2F3 E2F4 SRSF10 GINS2 CASP8AP2 H2AZ2 CDKN1B POLS EGF TOP2A MAPK14 PML NUMA1 CUL4A KIF11 MEIS1 pk BRCA2 KIF15 KIF23 SMC1A ESPL1 INCENP BIRC5 PAFAH1B1 EZH2 JPT1 TTK AURKA MKI67 CDC20 KATNA1 PTTG1 CHEK1 CDK4 HUS1 ILF3 DDX39A DBF4 TGFB1 CENPE MARCKS CENPF SLC12A2 PRC1 NOLC1 PDS5B ORC6 RAD21 BARD1 CDKN3 PLK4 SAP30 HMGA1 CCND1 POLA2 STAG1 CDC25B UBE2S HNRNPD H2AX SUV39H1 HMGB3 CTCF CKS1B HMMR MYBL2 LBR POLE CKS2 MCM3 MCM5 MCM6 MCM2 PRIM2 AURKB NASP TRA2B H2AZ1 CDKN2C TACC3 MAD2L1 SMC4 ARID4A SMC2 MT2A RPS6KA5 SNRPD1 CDC27 NUSAP1 HMGN2 TLE3 NEK2 SLC38A1 SMARCC1 FBXO5 PRP4K KNL1 TRAIP DKC1 HEL-S-61 EWSR1 NCL KNTC2 NUP98 ATF5 CUL5 CENPA YTHDC1 TROAP EFNA5 HIF1A STIL UBE2C CBX1 FANCC CDC6 FOXN3 KIF20B SQLE UCK2 MNAT1 SETD8 NOTCH2 AMD1 HOXC10 CHAF1A CHMP1A HALLMARK_FATTY_ACID_METABOLISM%MSIGDBHALLMARK%HALLMARK_FATTY_ACID_METABOLISM HALLMARK_FATTY_ACID_METABOLISM CD36 ACSM3 ECI2 AQP7 CPOX UBE2L6 HEL-76 ENO3 IL4I1 TDO2 HEL-S-53e UROD MLYCD PIG59 ACOT8 CPT1A GABARAPL1 MIX23 ACSL1 ACSL5 SDHD SDHA ALDH3A2 ALDH3A1 GPD1 SMS SUCLG2 SUCLG1 GCDH IDI1 SLC22A5 MAOA CD1D ADH7 ADIPOR2 ACAT2 NTHL1 RDH11 HAO2 DECR1 PDHA1 NCAPH2 UROS CIDEA DHCR24 HEL-S-128m VNN1 OSTC FASN CYP1A1 SERINC1 ACO2 REEP6 RETSAT ACADVL CYP4A22 HCCS NR1C1 PTPRG MCEE ACADL CPT2 CA4 IDH3B HEL-S-107 ACADM ACADS ADSL HSDL2 NBN HMGCS1 ELOVL5 CYP4A11 FACL4 HEL-S-25 S100A10 INMT HADHB UGDH HEL-S-278 ACOX1 EHHADH MGLL FH ECHS1 ADH1C HPGD ETFDH HSD17B4 EPHX1 LTC4S HSD17B11 HSD17B7 BPHL HSD17B10 PTS CRYZ HMGCL TP53INP2 D2HGDH SDHC PCBD1 ACSS1 MIF AADAT G0S2 GAD2 FABP1 ENO2 GSTZ1 FABP2 SUCLA2 APEX1 CRAT METAP1 HEL-S-133P HEL-S-32 H2AZ1 ME1 HEL-S-26 DLD GPD2 ALDH9A1 HEL-S-87p MDH2 SETD8 HALLMARK_TNFA_SIGNALING_VIA_NFKB%MSIGDBHALLMARK%HALLMARK_TNFA_SIGNALING_VIA_NFKB HALLMARK_TNFA_SIGNALING_VIA_NFKB MAFF PLEK VEGFA MYC KYNU PTX3 OLR1 DUSP5 SERPINB2 F3 RNF19B MAP2K3 CEBPB IER5 TNLG5A SQSTM1 TAP1 CCL5 NINJ1 ATF3 JUN GADD45A MARCKS PLK2 LIF PTPRE BMP2 TNC G0S2 MXD1 TNF CCND1 BTG2 CDKN1A CD83 BTG1 CSF2 CSF1 CD80 ETS2 IFIT2 ZFP36 ZC3H12A CCRL2 NAMPT SLC16A6 IL12B MAP3K8 DENND5A PHLDA2 CCNL1 PHLDA1 JUNB MCL1 ICOSLG GEM IER2 IL15RA SPHK1 IL23A SIK1 PLPP3 TRIB1 IL6ST FOS BHLHB2 FUT4 BTG3 SOCS3 SNN IL1A MSC ABCA1 EGR1 SDC4 EGR2 TIPARP TNFRSF9 HBEGF NFKB1 PPP1R15A NFKB2 FOSL2 NFKBIA EFNA1 FOSL1 RCAN1 YRDC IL18 CXCL11 NR4A3 GADD45B BCL6 GPR183 B4GALT1 REL NFKBIE INHBA IL7R IRF1 NFE2L2 IL1B DRAM1 IL6 RIGI TNFAIP6 TNFAIP2 SLC2A3 CXCL3 BIRC3 LITAF ID2 SLC2A6 CXCL2 PANX1 IFIH1 PDE4B RELA KLF10 TGIF1 DUSP4 CXCL6 KDM6B KLF4 EDN1 DUSP2 RIPK2 IFNGR2 TRAF1 TNFAIP3 SERPINB8 TUBB2A CXCL1 SGK1 FJX1 AREG BIRC2 CD69 CYR61 B4GALT5 PTGER4 NFAT5 BCL2A1 CEBPD PTGS2 TANK SUI1 RELB NFIL3 DNAJB4 CCL4 CCL2 HES1 LDLR LAMB3 PLAUR CCL20 ATP2B1 KLF2 PNRC1 RHOB PER1 SPSB1 KLF6 TNIP2 CLCF1 KLF9 TRIP10 TMEPAI ACKR3 F2RL1 FOSB CD44 EHD1 HALLMARK_HEDGEHOG_SIGNALING%MSIGDBHALLMARK%HALLMARK_HEDGEHOG_SIGNALING HALLMARK_HEDGEHOG_SIGNALING SLIT1 NRCAM NKX6-1 L1CAM CDK6 MYH9 VEGFA ETS2 HEY2 NF1 CDK5R1 PTCH1 PML OPHN1 TLE3 SCG2 THY1 ACHE CNTFR NRP1 NRP2 RTN1 LDB1 CRMP1 PLG CELSR1 AMOT VLDLR SHH HALLMARK_CHOLESTEROL_HOMEOSTASIS%MSIGDBHALLMARK%HALLMARK_CHOLESTEROL_HOMEOSTASIS HALLMARK_CHOLESTEROL_HOMEOSTASIS ERRFI1 GLDC CLU TMEM97 ANTXR2 ACTG1 CXCL16 TM7SF2 FADS2 FBXO6 HEL-S-4 GNAI1 STARD4 PCYT2 GPX8 SREBF2 ETHE1 PPARG EBP STX5A MVD ACSS2 HEL-S-7 MVK SEMA3B LPL HMGCR ATXN2 PMVK TP53INP1 MAL2 FDFT1 CTNNB1 NIBAN1 FDPS ABCA2 GSTM2 CHKA HEL-S-43 CYP51A1 FABP5 PLSCR1 SCD CD9 DHCR7 CPEB2 AVPR1A IDI1 ACAT2 GUSB TRIB3 ATF3 SC5D FASN NFIL3 TNFRSF12A HMGCS1 LDLR PLAUR PNRC1 ATF5 PDK3 HSD17B7 SQLE HALLMARK_INFLAMMATORY_RESPONSE%MSIGDBHALLMARK%HALLMARK_INFLAMMATORY_RESPONSE HALLMARK_INFLAMMATORY_RESPONSE SLC7A1 MYC OLR1 GP1BA F3 CD82 KIF1B NPFFR2 IRF7 CSF3 LCP2 IFITM1 CSF3R AQP9 ICAM4 AHR SLC4A4 IL18RAP RGS1 LAMP3 CLEC5A C3AR1 PROK2 LCK ROS1 TNLG5A SCN1B GNAI3 CMKLR1 IL1R1 SLC11A2 RAF1 CYBB IFNAR1 LY6E CALCRL CCL5 EBI3 C5AR1 FPR1 CD55 LPAR1 SLC1A2 MEFV HRH1 IRAK2 NLRP3 NDP ARHG MSR1 FZD5 EIF2AK2 NMI SELE BST2 MARCO SELL NMUR1 SELS RTP4 CD40 CXCL9 ATP2A2 ADM CX3CL1 GPR132 STAB1 BDKRB1 ITGB8 CCR7 FFAR2 IL10 PTGIR TNLG1B TACR3 TACR1 TNFRSF1B OSMR TAPBP TLR1 RNF144B HEL-S-75 MEP1A LTA CD48 TLR3 PTGER2 KCNA3 CXCR6 NOD2 SGMS2 LIF SRI ATP2C1 SLC7A2 CCL7 PTPRE P2RY2 PDPN HAS2 CCL17 KCNJ2 CCL24 GABBR1 CCL22 MXD1 SEMA4D SLC31A2 SLC31A1 PCDH7 IL10RA ADRM1 TNFSF10 BTG2 OSM CDKN1A OPRK1 ACVR2A P2RX7 CSF1 EREG P2RX4 AXL IL2RB TNLG8A VIP PSEN1 IL18R1 CCRL2 NAMPT IL12B CD14 ICOSLG IL15RA SPHK1 IL1A ABCA1 TNFRSF9 HBEGF NFKB1 NFKBIA RGS16 IL18 CXCL11 ACVR1B GPR183 INHBA IL7R IRF1 IL1B IL6 TNFAIP6 PDE4B RELA GNA15 CXCL6 CXCL8 EDN1 RIPK2 IFNGR2 ITGB3 CD69 ADORA2B PTGER4 TIMP1 MET IL15 CCL2 LDLR PLAUR CCL20 ATP2B1 EMP3 PIK3R5 KLF6 GPC3 HIF1A MMP14 LYN TPBG HALLMARK_TGF_BETA_SIGNALING%MSIGDBHALLMARK%HALLMARK_TGF_BETA_SIGNALING HALLMARK_TGF_BETA_SIGNALING ID2 SLC20A1 KLF10 TGIF1 SPTBN1 IFNGR2 CDKN1C BMPR2 HDAC1 FURIN ARID4B LTBP2 FNTA SKIL LEFTY2 JUNB ACVR1 NCOR2 UBE2D3 SMAD1 WWTR1 SMURF2 SMURF1 CTNNB1 NOG SMAD6 TGFBR1 HIPK2 TJP1 CDK9 FKBP1A SKI RAB31 ARHA MAP3K7 ID1 ID3 BMPR1A ENG PPP1R15A TGFB1 TMEPAI APC THBS1 BMP2 HALLMARK_INTERFERON_GAMMA_RESPONSE%MSIGDBHALLMARK%HALLMARK_INTERFERON_GAMMA_RESPONSE HALLMARK_INTERFERON_GAMMA_RESPONSE HLA-DMA SLC25A28 PSMB2 STAT4 FCGR1A PFKP GBP4 PTPN1 CD74 STAT1 MX2 P2RY14 STAT3 MX1 LYSMD2 PSMB8 ZNFX1 PTPN6 PML UBE2L6 PLSCR1 IRF2 IFI30 IRF7 LCP2 C1S C1R CMKLR1 TRAFD1 TAP1 LY6E CCL5 FPR1 NOD1 TXNIP GZMA RAPGEF6 EIF2AK2 NMI BST2 RIPK1 RTP4 CD40 CXCL9 STAT2 SOCS1 ARL4A MYD88 MTHFD2 TAPBP SRI CCL7 IFITM3 IL10RA TNFSF10 RBCK1 CDKN1A BTG1 IL2RB IFIT2 NAMPT IL15RA SOCS3 VAMP8 CASP8 CASP3 CASP4 ISG20 SAMD9L NFKB1 IFITM2 SPPL2A IFI35 NFKBIA IFIT1 IFI44L IFIT3 PNP VCAM1 DHX58 CXCL11 EPSTI1 TRIM25 CMTR1 B2M TRIM21 HERC6 IRF1 ZBP1 IFNAR2 IL6 RIGI RSAD2 TNFAIP6 SP110 TNFAIP2 HLA-B ARID5B HLA-A HLA-G NUP93 IFI27 PSME2 IFIH1 CMPK2 PDE4B TRIM14 IDO1 CSF2RB HELZ2 KLRK1 RNF213 ST8SIA4 RIPK2 ISOC1 SLAMF7 ST3GAL5 TNFAIP3 FAS HLA-DQA1 PNPT1 AUTS2 IFI44 CD69 ISG15 TDRD7 PARP14 TOR1B MHC2TA PARP12 PTGS2 MT2A SELP IL7 SSPN PIM1 XAF1 GPR18 HLA-DRB1 LGALS3BP IL15 CCL2 OGFR EIF4E3 SERPING1 SECTM1 LAP3 ADAR OASL CFH IL18BP ITGB7 BATF2 ApoL6 TMT1B LATS2 BANK1 HIF1A OAS2 PSMA2 IRF4 OAS3 PELI1 XCL1 IRF8 VAMP5 IRF9 RNF31 MARCHF1 MVP FGL2 USP18 PSMB10 HALLMARK_UV_RESPONSE_DN%MSIGDBHALLMARK%HALLMARK_UV_RESPONSE_DN HALLMARK_UV_RESPONSE_DN CAP2 SLC7A1 MYC COL3A1 IRS1 PRDM2 NR3C1 PMP22 IGF1R PPARG ZMIZ1 AKT3 CDON IGFBP5 SFMBT1 PRKCE DYRK1A CDKN1B POLS PRKCA RUNX1 MAPK14 INPP4B MAP1B PTEN SCN8A AMPH MT1E F3 PTGFR INSIG1 CACNA1A KALRN LTBP1 ATXN1 GRK5 MAP2K5 DMAC2L FZD2 RBPMS NR1D2 PHF3 SLC67A1 CELF2 SCHIP1 FHL2 PIK3CD PTPRM PTPN21 SYNE1 NIPBL DBP SIPA1L1 ABCC1 WDR37 MIOS ANXA2 ANXA4 VAV2 TGFBR2 ARHGEF9 RASA2 PLCB4 MMP16 FYN KCNMA1 KIT LPAR1 PIK3R3 GCNT1 MRPS31 TFPI ADD3 SPOP APBB2 ATP2B4 PEX14 FAM179B NFIB AGGF1 ADGRL2 MGLL CDC42BPA SRI ATP2C1 HAS2 ACVR2A RGS4 GJA1 SDC2 PLPP3 BHLHB2 TJP1 ID1 BMPR1A NFKB1 FBLN5 BDNF CITED2 COL1A1 VLDLR RXRA COL1A2 COL5A2 SNAI2 ERBB2 ITGB3 MGMT LAMC1 CYR61 ADORA2B MET LDLR ATP2B1 YTHDC1 TGFBR3 NRP1 NOTCH2 HALLMARK_IL6_JAK_STAT3_SIGNALING%MSIGDBHALLMARK%HALLMARK_IL6_JAK_STAT3_SIGNALING HALLMARK_IL6_JAK_STAT3_SIGNALING PTPN1 TNF STAT1 STAT3 CSF2 CSF1 IL18R1 MAP3K8 CD36 CD14 IL15RA IL6ST SOCS3 CD9 CSF3R IFNGR1 STAM2 CXCL11 TNFRSF1A ACVR1B IRF1 IL1R1 IL1B IL6 IFNAR1 CXCL3 EBI3 BAK1 IL2RG CSF2RB IFNGR2 ITGB3 ACVRL1 FAS CXCL13 CXCL1 LEPR HAX1 ITGA4 IL1R2 DNTT TYK2 CXCL9 IL17RB IL17RA IL3RA STAT2 LTB PTPN11 TNFRSF21 IL9R IL7 CBL PIM1 CSF2RA SOCS1 PDGFC TNFRSF12A IL12RB1 A2M HMOX1 CCR1 IL10RB PLA2G2A INHBE GRB2 TNFRSF1B IL2RA MYD88 OSMR LTBR CRLF2 PF4 PIK3R5 JUN TGFB1 CD44 CNTFR IRF9 IL13RA1 CCL7 HALLMARK_DNA_REPAIR%MSIGDBHALLMARK%HALLMARK_DNA_REPAIR HALLMARK_DNA_REPAIR SAC3D1 POM121 AK1 XPC RFC4 LIG1 ARL6IP1 MPG GTF2B CLP1 MPC2 HEL74 GTF2F1 RBX1 BCAM HPRT1 GC20 SRSF6 VPS28 CCNO TSG101 NPR2 CSTF3 COX17 SUPT4H1 AAAS BOLA2B SDCBP DGUOK ZNF707 SURF1 ADA POLR3GL ALYREF UPF3B ADRM1 SUPT5H ZWINT POLA2 POLA1 AGO4 STX3A RNP24 FEN1 ELL CETN2 SNAPC5 SEC61A1 MRPL40 ZNRD1 GUK1 SNAPC4 REV3L AK3 DKFZp781O1323 DGCR8 ELOA NELFB POLL NELFCD NCBP2 NME3 VPS37D RFC3 NME4 RFC2 EDF1 VPS37B APRT NT5C3A DDB2 DDB1 RRM2B NFX1 POLR1C POLR1D HCLS1 UMPS RALA CANT1 GTF3C5 RNMT PRIM1 PCNA USP11 GPX4 DCTN4 POLD3 GMPR2 TAF9 PNP TYMS ADCY6 POLD4 POLR2A POLR2C POLR2D POLR2F POLR2G POLR2H POLR2I POLR2J RAE1 DUT POLR2K BRF2 TAF12 PDE6G TAF13 TAF10 GTF2H3 CMPK2 PDE4B GTF2H5 TARBP2 SSRP1 RAD52 RAD51 POLE4 POLR3C NUDT21 IMPDH2 ERCC1 ERCC2 BCAP31 RPA3 TAF6 DFNA5 ERCC5 CDA HALLMARK_ADIPOGENESIS%MSIGDBHALLMARK%HALLMARK_ADIPOGENESIS HALLMARK_ADIPOGENESIS EPHX2 CHCHD10 RMDN3 COQ9 DNAJC15 COQ5 CS COQ3 UCK1 REEP5 UQCRQ NMT1 NABP1 PEMT SLC25A1 COX7B ORM1 RNF11 SOWAHC HSPB8 ETFB PPARG GPHN AIFM1 ALDH2 CD36 NKIRAS1 DBT LPL DLAT YWHAG ADIG COX8A JAGN1 CHUK ELMOD3 ELOVL6 MRAP PPM1B NDUFS3 ITGA7 CD302 PPP1R15B NDUFB7 SLC66A3 LAMA4 DHCR7 PTGER3 UQCR11 RETN UQCR10 AGPAT3 SAMM50 DDT GPAT4 UCP2 UBQLN1 DNAJB9 SNCG DRAM2 MAP4K3 PTCD3 ANGPT1 SUCLG1 CAVIN1 NDUFA5 CAVIN2 RIOK3 SQOR VEGFB CYP4B1 ADIPOR2 IMMT DHRS7 PFKL FABP4 GPAM DECR1 CCNG2 LEP HEL-S-62p LPCAT3 NDUFAB1 CIDEA ATP5PO ESYT1 PEX14 ACO2 REEP6 RETSAT ACADL CPT2 ACADM ACADS ARL4A ACOX1 MGLL ECHS1 GADD45A LTC4S AK2 SDHC CRAT MYLK COL4A1 ABCA1 GPX4 GPX3 IFNGR1 ADCY6 BCL6 TOB1 CDKN2C STOM ME1 SCARB1 HEL-S-26 MTCH2 SLC27A1 ARAF GHITM COX6A1 LIPE ENPP2 PIM3 PHYH DGAT1 SLC25A10 MCCC1 ANGPTL4 TANK OMD ATP1B3 SSPN CMBL SDHB DLD SLC5A6 ACLY GPD2 POR ADFP RAB34 CMPK1 HEL-S-87p UQCRC1 SPARCL1 PREB RTN3 CD151 MTARC2 MGST3 ABCB8 BAZ2A MRPL15 PRDX3 SULT1A1 GRPEL1 MDH2 DHRS7B UBC G3BP2 APOE CYC1 RREB1 HEL-S-44 SLC19A1 ESRRA FZD4 HEL107 HALLMARK_ALLOGRAFT_REJECTION%MSIGDBHALLMARK%HALLMARK_ALLOGRAFT_REJECTION HALLMARK_ALLOGRAFT_REJECTION HLA-DMA STAT4 CD74 STAT1 CTSS PTPN6 HEL-S-71 MAP3K7 IRF7 LCP2 CCND3 NCK1 CCND2 PRKCB IL18RAP TRAF2 LCK WAS F2R CD1D TAP1 CCL5 GCNT1 IL2RG GZMA NLRP3 SPI1 EGFR GPR65 NCF4 CD40LG UBE2D1 RPL9 IL27RA RPS19 CXCL13 SIT1 IL12A HLA-DOA HLA-DOB RPL39 TPD52 CD40 CD96 CXCL9 RPS9 KRT1 TAP2 LTB CARTPT HLA-E IL4 STAB1 CD8A FLNA AARS1 SOCS1 IGSF6 TNFSF6 CFP IL12RB1 CD79A IL10 ELANE CCR1 SOCS5 FYB1 CRTAM LY86 IL2RA IL2 RPL3L TAPBP PTPRC TLR1 PF4 IL9 HLA-DRA TGFB1 DEGS1 KLRD1 ITK TLR3 DYRK3 CD3G CD3E CD3D IKBKB LIF MRPL3 INHBB CCR5 CCR2 MBL2 CCL7 RARS1 EIF5A MAP4K1 SRGN IL11 IL13 CD8B1 IL16 RPS3A CCL22 MMP9 PRF1 NCR1 ZAP70 IFNG TNF ELF4 CD47 BCAT1 CCL13 CCL11 ACVR2A MTIF2 CSF1 EREG HDAC9 CD80 HLA-DMB CXCR3 IL2RB CSK CCL19 GBP2 BCL10 NPM1 NOS2 TRAT1 IL12B GALNT1 c-fgr CD7 EIF3J ABCE1 HEL-S-66 FCGR2B EIF3D ICOSLG EIF3A BRCA1 HCLS1 THY1 IFNGR1 IL18 F2 B2M INHBA IL1B IFNAR2 IL6 HLA-A HLA-G CDKN2A ST8SIA4 RIPK2 IFNGR2 FAS HLA-DQA1 CD2 IL7 TIMP1 CCL4 IL15 CCL2 C2 HIF1A IRF4 ACHE LYN IRF8 PSMB10 HALLMARK_INTERFERON_ALPHA_RESPONSE%MSIGDBHALLMARK%HALLMARK_INTERFERON_ALPHA_RESPONSE HALLMARK_INTERFERON_ALPHA_RESPONSE SLC25A28 IFITM3 GBP4 CD74 CD47 MX1 CSF1 PSMB8 IFIT2 GBP2 CCRL2 TMEM140 NUB1 TRIM5 HLA-C TENT5A ELF1 OAS1 NCOA7 UBE2L6 CNP SAMD9 UBA7 PLSCR1 GMPR CASP8 MVB12A MOV10 IRF2 IFI30 IRF7 ISG20 IFITM1 SAMD9L IFITM2 IFI35 IFI44L IFIT3 C1S LAMP3 DHX58 CXCL11 EPSTI1 TRIM25 CMTR1 B2M TRIM21 HERC6 IRF1 RSAD2 TRAFD1 SP110 TAP1 LY6E PROCR IFI27 IFIH1 PSME2 CMPK2 TXNIP TRIM14 HELZ2 RIPK2 EIF2AK2 NMI BST2 PNPT1 SELL IFI44 RTP4 ISG15 TDRD7 PARP14 STAT2 PARP12 IL7 LGALS3BP IL15 OGFR ADAR LAP3 OASL BATF2 IRF9 RNF31 USP18 HALLMARK_ESTROGEN_RESPONSE_EARLY%MSIGDBHALLMARK%HALLMARK_ESTROGEN_RESPONSE_EARLY HALLMARK_ESTROGEN_RESPONSE_EARLY MPPED2 TFF1 FOXC1 SLC24A3 ATL1 TMPRSS3 ASB13 SLC7A5 ADCY1 PAPSS2 THSD4 TMEM164 ABLIM1 MUC1 PDLIM3 OLFML3 LRIG1 MYC RBBP8 SH3BP5 EEIG1 HSPB8 MICB IGF1R CA12 SVIL KDM4B NHERF1 ZNF185 SEMA3B AMFR KRT13 SNX24 NCOR2 DHRS2 KLK10 DHRS3 TTC39A FDFT1 KRT19 MLPH MYBBP1A CHPT1 RAB17 GLA FRK TJP3 ABAT DHCR7 FHL2 SLC22A5 ADD3 FASN IL17RB FLNB ELOVL5 SFN SLC19A2 FARP1 INHBB SLC7A2 P2RY2 CCND1 FKBP4 GJA1 IGFBP4 PMAIP1 STC2 ELF1 IL6ST FOS BHLHB2 RAB31 FCMR WWC1 TIPARP HR CANT1 NADSYN1 AQP3 CELSR2 RAPGEFL1 SOX3 DEPTOR RPS6KA2 MYB TBC1D30 CCN5 SLC39A6 SYBU B4GALT1 MREG CISH TOB1 NPY1R KAZN KCNK15 OVOL2 RARA SULT2B1 OLFM1 CXCL12 ADCY9 CLDN7 SCNN1A PPIF PGR NBL1 SLC27A2 PTGES KLF10 FKBP5 SLC26A2 HEL-S-10 KLF4 MINDY1 TPD52L1 ARL3 ABHD2 SLC1A1 ENDOD1 SCARB1 ISG20L2 RHOBTB3 SLC1A4 UGCG MED24 KRT18 SYNGR1 AREG ELF3 CALCR INPP5F ALDH3B1 TFF3 BAG1 TFAP2C XBP1 OPN3 SLC37A1 WFS1 SIAH2 ABCA3 GREB1 MED13L REEP1 HES1 KCNK5b BCL2 UNC119 RETREG1 RET LAD1 CLIC3 NXT1 PRSS23 AFF1 CALB2 CYP26B1 ANXA9 MYBL1 MSMB TGIF2 TIAM1 DYNLT3 CD44 ELOVL2 ITPK1 TPBG MYOF PLAAT3 GAB2 NAV2 CELSR1 CBFA2T3 RHOD ESRP2 HALLMARK_HYPOXIA%MSIGDBHALLMARK%HALLMARK_HYPOXIA HALLMARK_HYPOXIA MAFF GPC1 PFKP ERRFI1 RBPJ SLC25A1 VEGFA NR3C1 CA12 CDKN1B PRKCA MT1E F3 ENO3 TES RORA KIF5A HEL-S-162eP IGFBP1 JMJD6 TPST2 BCAN PPP1R3C PKP1 LXN HACL2 FOXO3A PRDX5 LARGE LYZG PCK1 B4GALNT2 PPARGC1A KLHL24 SRPX CAVIN1 NCAN HEXA HEL-S-134P ANXA2 PYGM BRS3 AKAP12 CSRP2 STBD1 ATP7A PFKL EDN2 GAA MYH9 CXCR4 DDIT3 AMPD3 CCNG2 DDIT4 FBP1 CHST3 TMEM45A S100A4 KDM3A DGIC EGFR HAS1 NOCT GCNT2 ATF3 VHL XPNPEP1 MAP3K1 PKLR CAVIN3 GCK HS3ST1 KLF7 NAGK INHA TPD52 ADM HMOX1 ERO1A HEL-S-278 JUN HEL-S-75 ZNF292 ENO1 HEL-S-89n DPYSL4 PDK3 MIF SAP30 ENO2 RRAGD CTGF KDELR3 BNIP3L CDKN1A BTG1 ZFP36 CDKN1C SDC2 SDC3 STC1 AK4 LOX STC2 ANKZF1 FOS BHLHB2 HEL-S-133P SDC4 B3GALT6 TIPARP EXT1 ISG20 PPP1R15A EFNA3 FOSL2 P4HA1 EFNA1 P4HA2 CCN5 CITED2 IL6 VLDLR HK2 SULT2B1 SLC2A3 GYS1 CASP6 TGFBI PGM2 SLC37A4 PGAM2 HEL-S-68p SCARB1 TNFAIP3 HEL-S-19 CYR61 ADORA2B MT2A ANGPTL4 ALDOB PIM1 SIAH2 NFIL3 ADFP BCL2 PLAUR HEL-S-87p DCN GLRX PNRC1 KLF6 MXI1 GPC3 GPC4 ACKR3 TPBG CP HEL-S-49 HALLMARK_UNFOLDED_PROTEIN_RESPONSE%MSIGDBHALLMARK%HALLMARK_UNFOLDED_PROTEIN_RESPONSE HALLMARK_UNFOLDED_PROTEIN_RESPONSE SLC7A5 NABP1 VEGFA HEL-S-125m IGFBP1 CEBPB DNAJB9 TSPYL2 DDIT4 HEL-S-99n ATF3 EIF4E EIF4A2 EIF4A1 POP4 EIF4A3 RRP9 EDC4 RPS14 TATDN2 KHSRP BANF1 CHAC1 IMP3 SLC30A5 DDX10 PDIA5 ERN1 NHP2 ATP6V0D1 ERO1A MTHFD2 TARS1 ATF4 SHC1 BAG3 EIF4EBP1 SSR1 SEC31A FUS HEL-S-89n EDEM1 LSM1 ASNS EEF2 LSM4 CNOT4 NOLC1 CNOT6 CNOT2 SRPRA SRPRB HYOU1 ALDH18A1 IARS DCP1A EIF4G1 FKBP14 SERP1 WIPI1 YWHAZ SKIC3 EIF2S1 DCP2 EXOC2 KDELR3 SKIV2L2 DCTN1 GOSR2 CEBPG CXXC1 SDAD1 EXOSC5 EXOSC10 EXOSC4 H2AX SEC11A EXOSC1 NPM1 PAIP1 NFYA NFYB SPCS3 CKS1B SPCS1 XPOT DNAJA4 PSAT1 STC2 IFIT1 DNAJC3 NOP56 TUBB2A SLC1A4 XBP1 WFS1 CCL2 DKC1 HEL-S-61 PREB HALLMARK_APICAL_SURFACE%MSIGDBHALLMARK%HALLMARK_APICAL_SURFACE HALLMARK_APICAL_SURFACE ADIPOR2 GSTM3 PCSK9 IL2RG IL2RB AKAP7 LYPD3 CX3CL1 SLC2A4 PKHD1 SCUBE1 FLOT2 APP ATP6V0A4 EPHB4 TMEM8B NTNG1 SLC34A3 ATP8B1 BRCA1 CD160 PLAUR NCOA6 ADAM10 GATA3 SULF2 RTN4RL1 CROCC MAL HEL-S-102 GHRL THY1 EFNA5 RHCG MDGA1 GAS1 SHROOM2 LYN B4GALT1 SRPX HALLMARK_HEME_METABOLISM%MSIGDBHALLMARK%HALLMARK_HEME_METABOLISM HALLMARK_HEME_METABOLISM ERMAP RBM5 HTATIP2 VEZF1 SPTB TENT5C KAT2B ERAF TFDP2 BMP2K TRIM58 HAGH KDM7A MARCHF2 SLC66A2 MOSPD1 CLCN3 ADD2 AGPAT4 NR3C1 RHD E2F2 TRAK2 FY MARCHF8 CIRSR DCAF10 SNCA RBM38 DMTN SMOX MOCOS FOXJ2 CTNS XPO7 PDZK1IP1 KLF3 EPOR KLF1 CPOX SLC25A38 HEL-76 SLC25A37 TSPO2 XK HEL-S-2a RHAG UROD YPEL5 LPIN2 TNRC6B MAP2K3 CCND3 ICAM4 ARHGEF12 UCP2 FOXO3A USP15 HEL-S-134P RIOK3 SLC11A2 HEL-S-62p UROS TFRC HBZ BCAM ASNS HEL-S-304 SDCBP BTG2 BNIP3L SLC7A11 ABCB6 H1-0 AQP3 GCLC ISCA1 NARF GDE1 SLC4A1 P4HA2 BACH1 CCDC28A PPP2R5B NUDT4 PSMD9 tal-1 RNF19A BTRC FBXO7 FBXO9 TNS1 CAST LMO2 ACSL6 SLC30A1 SLC6A8 GAPVD1 MYL4 MINPP1 RNF123 KEL hEMMPRIN DAAM1 ADD1 HMBS GLND1 RHCE HEL-S-10 OPTN ABCG2 OSBP2 SIDT2 SLC22A4 ENDOD1 EPB42 FECH GYPC IGSF3 GYPB GYPE DCUN1D1 HTRA2 HEL-S-11 ADIPOR1 SLC30A10 GATA1 RAP1GAP LAMP2 CDC27 SPTA1 TSPAN5 CDR2 FN3K NFE2 H4C9 EIF2AK1 SLC10A3 FBXO34 TYR RCL1 MFHAS1 ARL2BP SLC6A9 SYNJ1 MGST3 MKRN1 MXI1 RANBP10 TMCC2 LRP10 GCLM EZH1 NFE2L1 TMEM9B PICALM ALAS2 HBB HBD FTCD HEBP1 NNT ACP5 CLIC2 PC HALLMARK_PROTEIN_SECRETION%MSIGDBHALLMARK%HALLMARK_PROTEIN_SECRETION HALLMARK_PROTEIN_SECRETION GOSR2 RNP24 ANP32E COPB2 CLCN3 CTSC ARF1 CLTC IGF2R PPT1 RPS6KA3 GLA ADAM10 ABCA1 KIF1B AP2M1 SNAP23 CLTA RAB22A GOLGA4 SCRN1 AP1G1 DST AP3S1 SH3GL2 RAB2A STX7 AP3B1 OCRL ARFGAP3 SCAMP3 TOM1L1 VAMP7 RER1 TMX1 ERGIC3 SEC22B VAMP4 ATP6V1B1 ATP7A VAMP3 NAPA CD63 STX12 TMED10 SGMS1 STX16 COPB1 VPS4B USO1 EGFR ATP1A1 NAPG CLN5 LMAN1 SNX2 TSPAN8 AP2S1 MAPK1 YKT6 ARFGEF2 KRT18 MON2 CAV2 TPD52 BNIP3 GBF1 M6PR ARCN1 RAB14 DOP1A GNAS LAMP2 SSPN YIPF6 RAB9A RAB5A COPE BET1 ARFGEF1 ZW10 SEC31A TSG101 HEL-S-44 COG2 HALLMARK_APICAL_JUNCTION%MSIGDBHALLMARK%HALLMARK_APICAL_JUNCTION HALLMARK_APICAL_JUNCTION SLIT2 ACTG1 MYH10 GNAI1 IRS1 AKT3 NF1 MVD MAPK14 PTEN WASL pk INSIG1 ICAM4 SHROOM2 RHOF SRC PFN1 VAV2 MYH9 PIK3R3 EGFR NF2 PLCG1 CX3CL1 CTNND1 ICAM2 INPPL1 FYB1 LNIR HEL-S-79 DMP1 ICAM5 ACTG2 PTPRC CDH8 SHC1 TIAL1 CDH4 SIRPA NRTN HEL70 SCAP2 GTF2F1 JAM3 ACTN1 CLDN6 CLDN5 CLDN4 TAOK2 ADAM15 CERCAM ALOX15B COL16A1 DSC1 DSC3 COL17A1 GRB7 WNK4 MYL12B CNN2 RRAS TSPAN4 SYMPK MMP9 RSU1 CD99 CLDN9 VASP CADM3 CDSN JUP CRAT CADM2 PARVA CDH6 CDK8 ITGB4 ARPC2 CD209 CNTN1 COL9A1 PALS1 ADRA1B PKD1 SGCE TRO SDC3 ADAMTS5 PS1TP5BP1 MDK DHX16 HRAS SPEG MADCAM1 IKBKG AMH CD34 CAP1 MAP4K2 SYK VWF HEL-S-20 TMEM8B KRT31 CLDN11 TJP1 TUBG1 ACTA1 CLDN15 CLDN14 CLDN19 EXOC4 PECAM1 EVL CDH15 NLGN3 TNFRSF11B NLGN2 THY1 AMIGO1 AMIGO2 NRXN2 PARD6G THBS3 LIMA1 VCAM1 ADAM23 NRAP CTNNA1 MPZL1 B4GALT1 MPZL2 NEGR1 NHERF4 SORBS3 MAPK13 MAPK11 BMP1 PPP2R2C ZYX NECTIN3 NECTIN2 CLDN7 CRB3 NECTIN1 TGFBI FBN1 ITGB1 BAIAP2 TRAF1 LAMC2 HEL114 ACTN2 ITGA2 ADAM9 MMP2 LAMB3 TSC1 ACTN4 CALB2 VCAN CDH11 STX4A LAMA3 HALLMARK_PANCREAS_BETA_CELLS%MSIGDBHALLMARK%HALLMARK_PANCREAS_BETA_CELLS HALLMARK_PANCREAS_BETA_CELLS LMO2 NKX6-1 PCSK2 PCSK1 STXBP1 NR1i1 SLC2A2 SRP14 FOXO1 INS NEUROD1 SCGN NKX2-2 ABCC8 PAX4 SEC11A PKLR PDX1 GCG PAX6 GCK ELP4 AKT3 HNF1A SYT13 ISL1 SPCS1 SRP9 G6PC2 MAFB SST DCX IAPP INSM1 FOXA2 NEUROG3 DPP4 SRPRB HALLMARK_XENOBIOTIC_METABOLISM%MSIGDBHALLMARK%HALLMARK_XENOBIOTIC_METABOLISM HALLMARK_XENOBIOTIC_METABOLISM CYP2J2 GSTM4 GCKR CYP4F2 IGF1 G6PC1 CYP26A1 TMEM97 LR8 CYP2S1 PAPSS2 CYP1A2 HRG NMT1 GUGU ABCD2 NR1C2 PEMT ALAS1 LEAP2 CROT AOX1 ACP2 MAN1A1 KYNU HGFAC ABCC3 ARG2 ABCC2 ALDH2 CD36 HEL-S-21 ARG1 DHPS SSR3 PTGR1 NPC1 SMOX ANGPTL3 TMBIM6 ACOX3 CYFIP2 CRP ITIH4 DDC KARS1 HEL-S-51e CYP17A1 HEL-76 PGRMC1 SERTAD1 ATOH8 TDO2 HSD17B2 XDH MARCHF6 IGFBP1 CCL25 LPIN2 MPP2 NQO1 PTGES3 GABARAPL1 F11 AQP9 DDT AKR1C2 HEL-S-182mP DHRS1 PINK1 GSTA3 CDO1 ALDH3A1 TNFRSF1A PLG IL1R1 MAOA ADH7 DHRS7 F10 FBP1 NINJ1 VNN1 GCNT2 EPHA2 CYP1A1 ACO2 RETSAT SLC35D1 ATP2A2 HMOX1 ELOVL5 UGDH ACOX1 PMM1 ADH1C ETFDH EPHX1 HPRT1 GAD1 BPHL MBL2 PTS TPST1 FABP1 JUP BCAT1 ETS2 IGFBP4 ARPP19 DCXR GCLC HEL-75 ID2 CASP6 PTGES HEL-S-10 HEL-S-26 FAS CDA NR2A1 MT2A RAP1GAP HEL-S-277 SLC46A3 PROS1 SLC35B1 POR CNDP2 PDK4 ALDH9A1 LONP1 HEL-S-64p TYR MCCC2 HES6 ENTPD5 SLC6A12 CYP27A1 RBP4 MTHFD1 CYP2E1 CES1 ENPEP SAR1B SLC22A1 GSTT2 ABHD6 IRF8 NDRG2 CYP2C18 APOE ADH5 HSD11B1 VTN pcap TTPA ASL PSMB10 PC HALLMARK_ANGIOGENESIS%MSIGDBHALLMARK%HALLMARK_ANGIOGENESIS HALLMARK_ANGIOGENESIS VAV2 SPP1 COL5A2 MSX1 S100A4 CXCL6 VEGFA COL3A1 POSTN OLR1 STC1 LPL PDGFA ITGAV TNFRSF21 TIMP1 APP JAG2 PF4 CCND2 VCAN LRPAP1 NRP1 THBD APOH PGLYRP1 KCNJ8 VTN PRG2 FSTL1 SLCO2A1 FGFR1 HALLMARK_MYOGENESIS%MSIGDBHALLMARK%HALLMARK_MYOGENESIS HALLMARK_MYOGENESIS AGRN IGF1 HDAC5 PSEN2 ABLIM1 COL3A1 HSPB8 DMD SVIL CD36 RB1 APP FDPS ITGA7 ENO3 SCD SPTAN1 NQO1 PPP1R3C ACSL1 SCHIP1 TSC2 LARGE COX6A2 PYGM SLN GJA5 MYOZ1 EPHB3 KCNH1 CHRNB1 GABARAPL2 GAA MYH9 MEF2C TPM3 DAPK2 FST MYL11 IFRD1 MYL7 MYL1 MYL2 MYL3 PVALB CFD CHRNA1 NOTCH1 FLII AEBP1 FOXO4 COX7A1 AK1 CNN3 EIF4A2 SYNGR2 IGFBP7 APOD PRNP CAV3 DMPK OCEL1 GNAO1 PKIA RIT1 FXYD1 HRC MYF6 RYR1 MYOM1 FHL1 ATP2A1 LDB3 MYL6B MYOM2 HSPB2-C11orf52 CSRP3 SGCA TGFB1 MB BDKRB2 ANKRD2 HEL-S-101 MYBPC3 MYOG TEAD4 PTGIS TNNC1 DENND2B TNNC2 HEL-S-29 SPARC SIRT2 MYH1 MYH2 PTP4A3 TNNT1 LPIN1 TNNT3 CASQ2 PLXNB2 MYH8 PICK1 HEL-S-273 MAPRE3 CASQ1 FGF2 CLU KIFC3 MYH4 tmp_locus_29 MYH7 CRAT MYLK CDKN1A CTF1 CKMT2 ITGB4 EFS CHRNG DKFZp686P11128 TNNI2 NCAM1 CACNG1 MEF2D PDLIM7 SH3BGR SH2B1 SPDEF MYBPH PDE4DIP MAPK12 MYO1C SPEG KLF5 FKBP1B TCAP CACNA1H PFKM WWTR1 SPHK1 STC2 COL4A2 ADAM12 BHLHB2 ACTA1 HBEGF GPX3 GADD45B SORBS3 COL1A1 TNNI1 ADCY9 SLC6A8 MYL4 ITGB1 ERBB3 TPD52L1 ITGB5 PGAM2 SGCD BAG1 SSPN ACTN2 SGCG REEP1 ACHE BIN1 AGL NAV2 PC HALLMARK_MTORC1_SIGNALING%MSIGDBHALLMARK%HALLMARK_MTORC1_SIGNALING HALLMARK_MTORC1_SIGNALING PSMC4 CTH TMEM97 SLC7A5 TM7SF2 NMT1 FADS2 PLK1 STARD4 NHERF1 IGFBP5 GSK3B CTSC HMGCR UBE2D3 SLA NIBAN1 ELOVL6 HEL-S-125m INSIG1 HEL-S-51e GLA TBK1 CYP51A1 TES SCD CD9 HEL-S-162eP DHCR7 IFI30 MAP2K3 ACTR3 ACTR2 FDXR IDI1 SQSTM1 ADIPOR2 IMMT PFKL RDH11 CXCR4 DDIT3 PIK3R3 DDIT4 DAPP1 ADD3 IFRD1 TRIB3 DHCR24 HEL-S-99n NUPR1 USO1 ACACA PSMG1 YKT6 TFRC AURKA M6PR ATP2A2 RRP9 RIT1 CFP HMGCS1 ELOVL5 DDX39A NFKBIB ERO1A MTHFD2 SSR1 ENO1 NUP205 HEL-S-89n SCAP2 EDEM1 ASNS HPRT1 PLOD2 SERP1 BTG2 BCAT1 CDKN1A SLC7A11 SEC11A NAMPT EBP STC1 AK4 PSAT1 PITPNB PSPH FADS1 ACSL3 SYTL2 MTHFD2L AF1Q FKBP2 BHLHB2 PSMD12 TUBG1 PSMD13 RPN1 CORO1A ATP6V1D HEL-S-94n HEL-S-133P HEL-S-66p SDF2L1 HSPA4 PNO1 MCM2 PPP1R15A EIF2S2 HEL-S-283 GCLC CCT6A P4HA1 UNG DHFR COPS5 EPRS1 PNP ATP5G1 PHGDH SORD CACYBP UCHL5 PSMA4 HEL-75 CANX EEF1E1 RAB1A VLDLR NUFIP1 HK2 TOMM40 ETF1 HSPD1 SLC2A3 HEL-S-69p GGA2 ABCF2 RRM2 CYB5B NFYC PDAP1 UFM1 ME1 PSMC6 RPA1 POLR3G HMBS SLC37A4 SC5D CCNG1 HEL-S-68p HEL-S-26 SLC1A4 XBP1 NFIL3 ACLY LDLR HEL-S-87p GLRX TUBA4A EGLN3 SQLE FGL2 HEL-S-49 HALLMARK_ESTROGEN_RESPONSE_LATE%MSIGDBHALLMARK%HALLMARK_ESTROGEN_RESPONSE_LATE HALLMARK_ESTROGEN_RESPONSE_LATE TFF1 FOXC1 SLC24A3 SERPINA1 TMPRSS3 SLC7A5 PAPSS2 PDLIM3 RBBP8 PTPN6 EEIG1 HSPB8 MICB ETFB CA12 NHERF1 GINS2 SEMA3B AMFR KRT13 NCOR2 DHRS2 TOP2A KLK10 FDFT1 KRT19 CHPT1 GLA HEL-76 FRK TJP3 FABP5 CD9 DHCR7 PTGER3 LARGE ALDH3A2 SLC22A5 ADD3 ATP2B4 HSPA4L IL17RB CDC20 FLNB ELOVL5 SFN FARP1 UGDH ST14 RNASEH2A HPRT1 TNNC1 HEL-S-29 PLK4 CCND1 KIF20A FKBP4 ZFP36 IGFBP4 MDK DCXR IL6ST FOS BTG3 RAB31 HR ISG20 CELSR2 RAPGEFL1 SOX3 RPS6KA2 MYB CCN5 SORD TFPI2 CISH TOB1 NPY1R MAPK13 OVOL2 SULT2B1 PERP OLFM1 CXCL12 SCNN1A ID2 PPIF PGR NBL1 SLC27A2 NAB2 PTGES CXCL14 FKBP5 TRIM29 SLC26A2 UNC13B HEL-S-10 KLF4 METTL3 TPD52L1 CACNA2D2 ARL3 DUSP2 PRLR ABHD2 PCP4 PKP3 SCARB1 LLGL2 IGSF1 LAMC2 SLC1A4 PLAC1 SGK1 HOMER2 XRCC3 AREG CALCR CYP4F11 TH ALDH3B1 GJB3 TFF3 BAG1 DLG5 TFAP2C GPER XBP1 NMU OPN3 PLXNB1 FGFR3 WFS1 SERPINA3 SIAH2 MOCS2 ABCA3 ST6GALNAC2 SNX10 SLC2A8 IMPA2 KCNK5b TPSAB1 BCL2 JAK1 CHST8 S100A9 EMP2 RET LSR DNAJC1 CLIC3 GAL NXT1 JDP1 PRSS23 SLC29A1 AFF1 ASCL1 AGR2 CYP26B1 TM4SF13 STIL ANXA9 ASS1 KLK11 BATF TIAM1 CDC6 DYNLT3 CD44 ITPK1 TPBG MYOF PLAAT3 HALLMARK_OXIDATIVE_PHOSPHORYLATION%MSIGDBHALLMARK%HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_OXIDATIVE_PHOSPHORYLATION COX6B1 OXA1L COX7A2L RHOT2 COXFA4 UQCRC2 UQCRB ABCB7 CS ATP5MC2 ATP5MC3 ATP5J COX7A2 UQCRQ ATP5H UQCRH ACAT1 ALAS1 MRPL11 TIMM50 COX7B CYB5R3 RHOT1 COX11 NDUFV2 ATP5MG ETFB ATP5MF ATP6V1C1 AIFM1 COX10 ATP5ME ATP6V1F ACADSB DLAT GLUD1 OGDH CYCS COX8A MRPS15 SLC25A3 COX4I1 MRPS11 MRPS12 ETFA TCIRG1 NDUFS3 MRPL34 COX7C MRPL35 OPA1 NDUFB7 TIMM17A UQCRFS1 TOMM70 ATP6V0B UQCR11 MRPS22 NDUFC2 UQCR10 CPT1A NDUFC1 BDH2 NDUFS8 NDUFS6 VDAC3 NDUFS4 SDHD NDUFS1 SDHA SLC25A12 SLC25A5 ATP6V0C FXN SLC25A11 SLC25A4 SUCLG1 SLC25A6 NDUFB8 NDUFA5 NDUFB6 NDUFB5 NDUFB4 TIMM9 PPM2C NDUFB3 NDUFB2 IMMT TIMM13 NDUFB1 MRPS30 TIMM10 DECR1 HEL-S-123m PDHA1 COX5A MFN2 SLC25A20 NDUFAB1 MST065 ATP5PO NDUFA9 TIMM8B NDUFA7 ISCU NQO2 NDUFA6 ATP5PB MTX2 ACO2 ZNF183 NDUFA3 RETSAT ACADVL NDUFA2 ATP5F1D HCCS ATP5F1E IDH3B LDHB ACADM HADHB FH LRPPRC ECHS1 ETFDH HSD17B10 COX17 SDHC SURF1 SUCLA2 GOT2 ATP6V1D HEL-S-133P ISCA1 GPX4 ATP5G1 HEL-S-32 POLR2F BAX HEL-S-26 COX6A1 HTRA2 PHYH SDHB DLD POR FDX1 PDK4 UQCRC1 MGST3 MRPL15 PRDX3 MTRR GRPEL1 MDH2 PHB2 HEL-S-271 MTRF1 MPC1 PMPCA CYC1 ATP6V1E1 PDHX ATP6V1G1 NNT ATP6V0E1 ATP1B1 HALLMARK_ANDROGEN_RESPONSE%MSIGDBHALLMARK%HALLMARK_ANDROGEN_RESPONSE HALLMARK_ANDROGEN_RESPONSE CDK6 PA2G4 CCND1 ADRM1 ZMIZ1 SPDEF ANKH SPCS3 HMGCR INPP4B H1-0 FADS1 KRT19 ACSL3 INSIG1 RPS6KA3 SCD CCND3 DNAJB9 PTPN21 SORD SMS B4GALT1 B2M HEL-75 GNAI3 IDI1 AKAP12 ARID5B FKBP5 SLC26A2 DHCR24 ABHD2 LMAN1 SGK1 HOMER2 SRP19 STEAP4 TPD52 NGLY1 DBI CDC14B HERC3 ITGAV PGM3 SMP1 NKX3-1 PIAS1 ALDH1A3 MAF HMGCS1 MAK ELOVL5 SELENOP PLPP1 STK39 TMPRSS2 KLK3 TARP MYL12A CAMKK2 UBE2J1 PTK2B RAB4A UBE2I XRCC5 HPGD APPBP2 TMEPAI VAPA ACTN1 CENPN GPD1L MERTK HALLMARK_KRAS_SIGNALING_UP%MSIGDBHALLMARK%HALLMARK_KRAS_SIGNALING_UP HALLMARK_KRAS_SIGNALING_UP SPP1 LR8 CTSS PRRX1 PSMB8 CROT ARG1 SEMA3B ADAM17 FCER1G HEL-76 RETN CCND2 SCG5 SCG3 NGF C3AR1 SCN1B CMKLR1 PCSK1N AKAP12 CXCR4 TFPI SNAP91 CIDEA IL2RG DOCK2 MAP3K1 APOD CBL CSF2RA ALDH1A3 TNFRSF1B ERO1A FUCA1 PLVAP SPON1 LIF HCA112 SOX9 F13A1 PRDM1 IKZF1 FGF9 BMP2 MAP4K1 FBXO4 EPHB2 ST6GAL1 ATG10 ANXA10 BTC G0S2 CLEC4A MMP9 SLPI PLAT MALL ADAM8 TRIB2 IL10RA ZNF277 TPH1 JUP ABCB1 LY96 CSF2 TSPAN7 EREG EPB41L3 HDAC9 PLEK2 KCNN4 TSPAN1 PRELID3B CBX8 IGF2 AMMECR1 PPBP NR0B2 ANKH GNG11 GADD45G CCSER2 STRN AVL9 PIGR SNAP25 MTMR10 FLT4 TMEM100 RBM4 CD37 VWA5A TRIB1 TEM5 CDADC1 PEG3 MMD PDCD1LG2 ETV4 MMP10 ETV5 WDR33 PECAM1 LAT2 MMP11 ZNF639 HBEGF ENG ALDH1A2 PPP1R15A TLR8 LCP1 SDCCAG8 USP12 RGS16 USH1C HOXD11 YRDC IL1RL2 RELN EMP1 GPNMB CBR4 MPZL2 IL33 PTCD2 GALNT3 INHBA IL7R H2BC3 IL1B GABRA3 NR1H4 LAPTM5 NAP1L2 WNT7A BIRC3 TMEM158 CFHR2 ID2 SPRY2 SATB1 ADGRL4 KLF4 PCP4 TRAF1 TNFAIP3 GYPC MAFB PTGS2 ANGPTL4 SERPINA3 ITGA2 PLAUR CCL20 SPARCL1 CFH GLRX RBP4 TM4SF13 F2RL1 IRF8 NRP1 HSD11B1 HALLMARK_BILE_ACID_METABOLISM%MSIGDBHALLMARK%HALLMARK_BILE_ACID_METABOLISM HALLMARK_BILE_ACID_METABOLISM EPHX2 ALDH8A1 FADS2 ABCD2 CROT NPC1 ABCA2 KLF1 ATXN1 HEL-S-53e MLYCD SLC67A1 AQP9 ACSL1 HEL-S-182mP FDXR ACSL5 PRDX5 LCK IDI1 DHCR24 RETSAT HSD17B4 HSD17B11 NR0B2 PFKM FADS1 ABCA1 RXRA NR1H4 SULT2B1 PECR SLC23A2 SLC35B2 SLC27A2 SLC23A1 CYP46A1 HEL111 NR3C2 PEX26 OPTN LONP2 NUDT12 ABCG8 ISOC1 DIO1 PIPOX HEL-S-26 CH25H GNPAT SOAT2 RBP1 PEX11G LIPE ABCG4 SLC27A5 HAO1 PHYH ABCA5 ABCA6 ABCA4 ABCA9 ABCA8 BMP6 ABCA3 SULT1B1 AMACR PXMP2 SLCO1A2 ABCD3 TFCP2L1 ALDH9A1 LOC51064 ABCD1 CYP7B1 PEX7 PEX6 EFHC1 CYP27A1 AGXT SLC29A1 PAOX AKR1D1 HSD17B6 CYP7A1 GCLM GC RXRG PEX16 HSD3B7 PEX19 PNPLA8 HSD3B1 NR1i2 BBOX1 HEL-S-44 PEX12 CYP8B1 PEX13 NEDD4 HALLMARK_MYC_TARGETS_V1%MSIGDBHALLMARK%HALLMARK_MYC_TARGETS_V1 HALLMARK_MYC_TARGETS_V1 PSMC4 HEL-S-276 RPL34 PSMB2 PWP1 RPL6 UBE2L3 EEF1B2 CCNA2 HDAC2 FBL PSMD7 SNRPD2 TRIM28 TFDP1 HNRPR RUVBL2 PSMD3 PSMD1 SNRPD3 MYC TXNL4A RPS10 CDC45 EIF1AX STARD7 RPS5 RPL22 RPS6 HEL-S-69 UBE2E1 TUFM CLNS1A SNRPG ERH SRSF7 SNRPA SET SLC25A3 GLO1 CSTF2 PCBP1 NOP16 KARS1 CBX3 MRPL23 SFRS3 LSM2 SRPK1 AIMP2 LSM7 UBA2 TOMM70 RNPS1 HNRNPC HSP90AB1 RPLP0 PTGES3 YWHAQ C1QBP DHX15 VDAC3 HNRPA3 AP3S1 MRPL9 NCBP1 VBP1 PABPC4 CAD GNL3 TCP1 SNRPA1 PABPC1 HEL-S-91n DDX21 U2AF1 PPM1G SRM PSMB3 FAM120A EIF4H RPL14 RPS3 SNRPB2 COX5A RPS2 CCT7 CCT4 NDUFAB1 RRM1 IFRD1 SF3A1 SSB CNBP HEL-S-100n RSL1D1 AAG1 HNRNPA2B1 POLE3 PRPF31 SSBP1 TARDBP EIF4E EIF3B EIF4A1 RRP9 CDC20 RFC4 CDK4 CDK2 NHP2 HPRT1 NOLC1 ORC2 IARS PA2G4 EIF2S1 APEX1 HNRNPD HEL-S-97n NPM1 XPOT EIF3J ABCE1 EIF3D NCBP2 CTPS1 GOT2 HEL-S-133P MCM5 MCM6 MCM2 EIF2S2 PCNA COPS5 EPRS1 TRA2B TYMS POLD2 USP1 PSMA4 CANX H2AZ1 NOP56 RANBP1 ETF1 HSPD1 DUT HEL-S-69p RPL18 PSMC6 DEK IMPDH2 MCM7 HEL-S-68p HEL2 RAN MAD2L1 SNRPD1 SMARCC1 PSMA2 PRDX3 PHB2 CYC1 HALLMARK_KRAS_SIGNALING_DN%MSIGDBHALLMARK%HALLMARK_KRAS_SIGNALING_DN HALLMARK_KRAS_SIGNALING_DN TENT5C MX1 KRT13 SERPINB2 EGF GP1BA PTGFR ZC2HC1C PKP1 ATP6V1B1 EDN2 MEFV CD40LG PNMT FGF22 CLSTN3 ARHGDIG IRS4 PARK2 KRT1 NUDT11 KLK8 TGM1 TCL1A VPREB1 CAPN9 SLC16A7 DCC PDK2 CPA2 KRT4 SELENOP RYR1 ENTPD7 UGT2B17 CDKAL1 HEL-S-79 KRT5 SOX10 THNSL2 EDAR SCN10A HEL-S-75 CLPS KCNQ2 SIDT1 CALCB CPB1 TNNI3 KCNE2 SHOX2 ZBTB16 CACNA1F MACROH2A2 SLC5A5 HSD11B2 FGGY KCNMB1 KCNN1 PRODH SLC38A3 SPTBN2 MLL2 TFAP2B BARD1 DTNB AMBN HTR1D HTR1B FGF16 AKR1B10 IFNG IL5 TG GDNF BTG2 MYH7 STAG3 ARPP-21 CYP11B2 KLHDC8A CHRNG CD80 PCDHB1 TLX1 CD207 CACNG1 CPEB3 ZFP112 GPR19 RYR2 TENM2 IL12B MAST3 IGFBP2 SERPINA10 OXT SLC6A3 SKIL LFNG CCR8 EFHD1 LYPD3 INSL5 TSHB TAS2R4 GRID2 CAMK1D KCND1 PROP1 HEL-S-20 SPHK2 FSHB NGB COPZ2 SNN PAX3 TEX15 ADRA2C UPK3B WNT16 SSTR4 COL2A1 MYOT GTF3C5 TFF2 CELSR2 CLDN16 ITGB1BP2 CDH16 IFI44L GPRC5C SLC29A3 SPRR3 ITIH3 SMPX NPY4R PLAG1 ALOX12B CCDC106 ABCB11 NR1A2 P2RY4 RSAD2 VPS50 NRIP2 NTF3 SLC25A23 SNCB RIBC2 LGALS7B SLC12A3 TCF7L1 GPR3 DLK2 P2RX6 NR6A1 NPHS1 EDN1 MYO15A SCGB1A1 YPEL1 PAX4 ASB7 MAGIX PDCD1 RGS11 SGK1 COQ8A BRDT HNF1A ABCG4 FGFR3 SYNPO TFCP2L1 IDUA CNTFR HALLMARK_PEROXISOME%MSIGDBHALLMARK%HALLMARK_PEROXISOME HALLMARK_PEROXISOME EPHX2 CRAT ABCB1 ABCD2 BCL10 HRAS TOP2A ABCC5 DHRS3 FADS1 FDPS ECI2 CTPS1 ATXN1 HEL-S-53e MLYCD PBR ACOT8 ACSL1 ACSL5 PRDX5 CADM1 SLC25A4 PABPC1 IDI1 SULT2B1 RDH11 HAO2 SLC23A2 SLC35B2 SLC27A2 HEL111 VPS4B DHCR24 CNBP PEX14 LONP2 ERCC1 SCGB1A1 ABCC8 ISOC1 DIO1 HEL-S-26 GNPAT RETSAT DKFZp667O1614 IDE STS NUDT19 PEX2 NR3A2 SLC25A17 PEX5 CRABP2 SEMA3C CTBP1 ABCB4 CRABP1 PEX11B CACNA1B SMARCC1 ABCB9 ELOVL5 CLN8 ABCD3 FIS1 FACL4 UGT2B17 ALDH9A1 SIAH1 LOC51064 CDK7 ABCD1 MSH2 DLG4 FABP6 ALB ACOX1 PEX6 EHHADH CLN6 HSD17B4 RXRG HSD17B11 HSD3B7 HSD11B2 NR1i2 HEL-S-44 MVP HMGCL PEX13 HALLMARK_MYC_TARGETS_V2%MSIGDBHALLMARK%HALLMARK_MYC_TARGETS_V2 HALLMARK_MYC_TARGETS_V2 HK2 MRTO4 HSPD1 SRM MPHOSPH10 PLK4 PA2G4 TMEM97 PLK1 EXOSC5 DUSP2 MYC NPM1 RRP9 MYBBP1A NOP16 CBX3 CDK4 AIMP2 RCL1 MCM5 NIP7 NOP2 PPAN DCTPP1 NOC4L RABEPK WDR43 UNG TCOF1 PES1 UTP20 FARSLA MAP3K6 PRMT3 WDR74 SORD NOLC1 IMP4 GNL3 TFB2M PPRC1 SLC19A1 BYSL LAS1L GRWD1 NOP56 NDUFAF4 HALLMARK_NOTCH_SIGNALING%MSIGDBHALLMARK%HALLMARK_NOTCH_SIGNALING HALLMARK_NOTCH_SIGNALING PSENEN NOTCH3 SAP30 TCF7L2 MAML2 HES1 FBXW11 FZD7 DTX1 CCND1 DTX2 PSEN2 DTX4 ST3GAL6 NR1C2 SKP1 FZD5 NOTCH1 RBX1 FZD1 LFNG NOTCH2 PRKCA KAT2A HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY%MSIGDBHALLMARK%HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY PFKP ATOX1 HEL-S-112 HEL-S-128m SRXN1 MGST1 MPO NDUFA6 ERCC2 PTPA HHEX HEL-S-97n SBNO2 MBP CDKN2D EGLN2 TXNRD2 SELS GLRX2 OXSR1 TXN IPCEF1 SCAF4 JUNB PRNP MSRA FES FTL LAMTOR5 HEL-S-2a GLRX NQO1 GCLC GPX4 GCLM GPX3 ABCC1 HEL-S-44 HEL-75 NDUFB4 HALLMARK_UV_RESPONSE_UP%MSIGDBHALLMARK%HALLMARK_UV_RESPONSE_UP HALLMARK_UV_RESPONSE_UP BCL2L11 MSX1 ALAS1 PDLIM3 ATP6V1C1 ATP6V1F TMBIM6 GLS HTR7 STARD3 HLA-F MAPK8IP2 CDC34 CHKA MRPL23 POLG2 HEL-76 PRPF3 SELENOW TYRO3 NPTXR UROD CHRNA5 CYB5R1 NKX2-5 NPTX2 CCND3 KLHDC3 GGH RAB27A EIF2S3 EIF5 NAT1 AGO2 FGF18 CDO1 ONECUT1 CLTB ARRB2 SPR SLC25A4 HYAL2 SIGMAR1 NUP58 TGFBRAP1 DDX21 MAOA WIZ SQSTM1 CLCN2 TAP1 RXRB DNAJB1 PPP1R2 EPCAM CREG1 MGAT1 E2F5 NTRK3 HSPA2 PLCL1 CDC5L CCK GRINA ATF3 CYP1A1 POLE3 AP2S1 YKT6 RRAD TFRC RFC4 PARP2 HMOX1 CDK2 TACR3 CCNE1 TARS1 SHOX2 EPHX1 ASNS BMP2 ENO2 BTG2 ABCB1 BTG1 FKBP4 CEBPG TCHH FEN1 H2AX CDKN1C FURIN IGFBP2 JUNB PPT1 IL6ST FOS CNP BTG3 RPN1 HEL-S-94n CASP3 COL2A1 AQP3 NFKBIA GPX3 IRF1 POLR2H IL6 OLFM1 SLC6A8 CYB5B BAK1 PPIF CXCL2 PDAP1 CDKN2B hEMMPRIN C4BPB DGAT1 HEL-S-87p DLG4 RET RHOB GAL SLC6A12 MMP14 TUBA4A SULT1A1 GRPEL1 FOSB LYN AMD1 HALLMARK_IL2_STAT5_SIGNALING%MSIGDBHALLMARK%HALLMARK_IL2_STAT5_SIGNALING HALLMARK_IL2_STAT5_SIGNALING MAFF NT5E SPP1 GBP4 MUC1 LRIG1 MYC IGF1R PTCH1 HEL-S-21 DHRS3 HEL-76 CD81 ENO3 RORA PLSCR1 CCND3 CCND2 GABARAPL1 AHR SERPINC1 ANXA4 CYFIP1 GUCY1B1 GPR65 IKZF2 PDCD2L IKZF4 SCN9A TNFRSF8 TNFSF11 CAPN3 SELL ENPP1 SLC39A8 IL1R2 TNFRSF4 SHE WLS SYNGR2 PRKCH S100A1 SWAP70 PRNP IL3RA FLT3LG LTB ADAM19 TNFRSF21 TWSG1 MAPKAPK2 GPR83 SOCS1 AGER SOCS2 CD79B IL10 PENK PLPP1 MAP6 SNX9 ICOS ARL4A POU2F1 TNFRSF1B IL2RA CCNE1 HOPX DRC1 CDC42SE2 PHTF2 CTSZ PTH1R ITGAE CD48 MYO1E GLIPR2 NCS1 PTGER2 NFKBIZ SH3BGRL2 CTLA4 SIAT4C LIF CCR4 BATF3 TNFRSF18 CKAP4 SERPINB6 BMP2 CDCP1 PTRH2 COL6A1 IL13 TLR7 ITGA6 IRF6 SMPDL3A IFITM3 MXD1 PLEC AHNAK CST7 COCH RRAGD IL1RL1 IL10RA PLAGL1 TNFSF10 LRRC8C ABCB1 DCPS CD83 PRAF2 CSF2 SPRY4 CSF1 HUWE1 P2RX4 ARHH TTC39B IL2RB SYT11 SNX14 ETFBKMT IL18R1 CDKN1C F2RL2 BMPR2 EEF1AKMT1 APLP1 FURIN MAP3K8 DENND5A MYO1C PHLDA1 HEL-S-66 IGF2R HIPK2 BHLHB2 BCL2L1 ETV4 CASP3 UMPS TNFRSF9 P4HA1 GPX4 RGS16 IFNGR1 PNP EMP1 GADD45B CISH HK2 SLC2A3 TRAF1 XBP1 ITGAV GATA1 SELP PIM1 NFIL3 AMACR ADFP BCL2 RHOB NOP2 KLF6 IRF4 BATF TIAM1 CDC6 CD44 IRF8 NRP1 UCK2 FGL2 HALLMARK_COAGULATION%MSIGDBHALLMARK%HALLMARK_COAGULATION HALLMARK_COAGULATION MAFF SERPINA1 CPQ PLEK HRG CTSO CTSH OLR1 SERPINB2 GP1BA F3 F8 RAC1 CD9 MMP15 F11 C1QA C1S C1R THBD SERPINC1 TMPRSS6 PLG FYN F10 HEL-S-62p ISCU APOC1 CFD KLKB1 KLF7 S100A1 KLK8 A2M PF4 MEP1A CAPN5 MBL2 SPARC SIRT2 MMP9 PLAT CLU COMP F2RL2 GDA MASP2 FURIN CPB2 PEF1 CFI PROZ GNG12 LEFTY2 TF PROC F13B ARF4 C8A RAA1 DUSP14 C8G VWF CTSK FGA MMP7 F9 DCT HEL-S-52 CASP9 MMP10 CRIP2 CPN1 PECAM1 P2RY1 SH2B2 MMP11 HEL-S-41 HTRA1 APOC3 APOC2 MSRB2 ANXA1 USP11 F2 TFPI2 BMP1 FBN1 ITGB3 TIMP3 NR2A1 TIMP1 LAMP2 PROS1 ITGA2 ADAM9 MMP2 SERPING1 MMP3 CFH C2 PRSS23 DPP4 MMP14 C9 S100A13 THBS1 GP9 GNB2 S< I>-METHYL-5-THIO-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-4361 S< i>-methyl-5-thio-α-D-ribose 1-phosphate degradation APIP MRI1 KYAT1 ENOPH1 ADI1 L-CYSTEINE DEGRADATION III%BIOCYC%PWY-5329 L-cysteine degradation III MPST GOT1 CISD1 L-GLUTAMATE DEGRADATION (VIA 4-AMINOBUTANOATE)%BIOCYC%PWY0-1305 L-glutamate degradation (via 4-aminobutanoate) GAD1 GAD2 GLUL ESTRADIOL BIOSYNTHESIS II%BIOCYC%PWY-7306 estradiol biosynthesis II CYP2A6 CYP19A1 DOCOSAHEXAENOATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7606 docosahexaenoate biosynthesis III (6-desaturase, mammals) HSD17B12 FADS2 ELOVL5 EHHADH ELOVL2 METHYLGLYOXAL DEGRADATION VI%BIOCYC%MGLDLCTANA-PWY methylglyoxal degradation VI LDHD GLUTARYL-COA DEGRADATION%BIOCYC%PWY-5177 glutaryl-CoA degradation GCDH ECHS1 ACAT2 ACAT1 L-ASPARAGINE BIOSYNTHESIS%BIOCYC%ASPARAGINE-BIOSYNTHESIS L-asparagine biosynthesis ASNS PHYTOL DEGRADATION%BIOCYC%PWY66-389 phytol degradation ALDH3A2 PECR MENAQUINOL-4 BIOSYNTHESIS II%BIOCYC%PWY-7998 menaquinol-4 biosynthesis II UBIAD1 SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%BIOCYC%PWY-6358 superpathway of D-myo< i>-inositol (1,4,5)-trisphosphate metabolism INPP1 IPMK INPPL1 PTEN OCRL SYNJ2 ITPKB INPP5B ITPKC MINPP1 INPP5A INPP5F SYNJ1 IMPA1 IMPA2 INPP5D ITPKA INPP5J BPNT2 INPP5K L-CYSTEINE BIOSYNTHESIS III (FROM L-HOMOCYSTEINE)%BIOCYC%HOMOCYSDEGR-PWY L-cysteine biosynthesis III (from L-homocysteine) CBS CTH SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo< i> biosynthesis DTYMK DUT RRM1 RRM2 CAD NME2 CTPS2 NME3 CTPS1 NME4 NTPCR NME5 TYMS DHODH NME1 NME6 RRM2B NME7 CMPK1 CMPK2 UMPS MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-8171 molybdenum cofactor biosynthesis GPHN SEROTONIN AND MELATONIN BIOSYNTHESIS%BIOCYC%PWY-6030 serotonin and melatonin biosynthesis TPH2 TPH1 DDC AANAT ASMT ZYMOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6074 zymosterol biosynthesis NSDHL HSD17B7 LBR TM7SF2 &GAMMA;-LINOLENATE BIOSYNTHESIS%BIOCYC%PWY-6000 γ-linolenate biosynthesis ACSL1 ACSM6 ACSBG1 ACSM5 ACSM4 SLC27A2 ACSBG2 FADS2 ACSM3 MRNA CAPPING II%BIOCYC%PWY-7379 mRNA capping II RNGTT RNMT CMTR1 CMTR2 PEPTIDO-CONJUGATES IN TISSUE REGENERATION BIOSYNTHESIS%BIOCYC%PWY-8355 peptido-conjugates in tissue regeneration biosynthesis DPEP1 ALOX12 LTC4S GSTM4 GGT5 GPX4 ALOX5 ALOX15 SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%BIOCYC%PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) IDI1 FDPS ACAT2 MVK ACAT1 GGPS1 HMGCS1 IDI2 PMVK MVD HMGCR HMGCS2 L-GLUTAMINE DEGRADATION%BIOCYC%GLUTAMINDEG-PWY L-glutamine degradation GLS2 GLS L-TYROSINE DEGRADATION%BIOCYC%TYRFUMCAT-PWY L-tyrosine degradation HGD TAT FAH HPD GSTZ1 NORADRENALINE AND ADRENALINE DEGRADATION%BIOCYC%PWY-6342 noradrenaline and adrenaline degradation PNMT ADH4 MAOB ALDH3A2 ALDH2 TOMT MAOA ADH1B COMT ADH6 N< I>-ACETYLGLUCOSAMINE DEGRADATION II%BIOCYC%PWY-6517 N< i>-acetylglucosamine degradation II AMDHD2 NAGK GNPDA1 GNPDA2 L-HISTIDINE DEGRADATION%BIOCYC%PWY-5030 L-histidine degradation HAL MTHFD1 UROC1 AMDHD1 FTCD NADH REPAIR%BIOCYC%PWY-6938 NADH repair NAXE NAXD GAPDH URACIL DEGRADATION I (REDUCTIVE)%ARACYC%PWY-3982 uracil degradation I (reductive) DPYS DPYD UPB1 SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%BIOCYC%PWY-6371 superpathway of inositol phosphate compounds PIP5K1A PIP5K1B PIP5K1C PLCG1 IP6K1 CDIPT IP6K3 IP6K2 FIG4 PIKFYVE PI4KA PLCH1 PI4KB PLCH2 PLCD3 PLCD4 PLCD1 PI4K2B MTMR14 PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B PIP4P2 PIP4P1 PPIP5K1 PLCZ1 PPIP5K2 PIP5KL1 PLCE1 PIP4K2A IPMK INPPL1 PIP4K2B PTEN PIP4K2C SACM1L OCRL ITPK1 SYNJ2 ITPKB PLCB3 PLCB4 INPP5B ITPKC PIK3CA MINPP1 PIK3C3 PLCB1 INPP5A PLCB2 PI4K2A SYNJ1 IPPK MTMR3 PIK3R4 INPP5D ITPKA PIK3R3 PIK3R2 INPP5J PIK3R1 PIK3R6 INPP5K PIK3R5 PLCG2 L-PROLINE DEGRADATION%BIOCYC%PROUT-PWY L-proline degradation ALDH4A1 PRODH METHYLGLYOXAL DEGRADATION I%BIOCYC%PWY-5386 methylglyoxal degradation I GLO1 HAGH L-ALANINE DEGRADATION%BIOCYC%ALANINE-DEG3-PWY L-alanine degradation GPT2 GPT ACETATE CONVERSION TO ACETYL-COA%BIOCYC%PWY0-1313 acetate conversion to acetyl-CoA ACSS3 ACSS2 ACSS1 SPERMINE AND SPERMIDINE DEGRADATION I%BIOCYC%PWY-6117 spermine and spermidine degradation I AOC3 SMOX SAT2 SAT1 PAOX L-TYROSINE BIOSYNTHESIS%BIOCYC%PWY-6134 L-tyrosine biosynthesis PAH ACYLCERAMIDE BIOSYNTHESIS AND PROCESSING%BIOCYC%PWY-8042 acylceramide biosynthesis and processing TGM1 CERS3 ALOX12B CYP4F22 ALOXE3 PNPLA1 SLC27A4 HOMOCARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-421 homocarnosine biosynthesis CARNS1 UMP BIOSYNTHESIS%BIOCYC%PWY-5686 UMP biosynthesis CAD UMPS DHODH GUANOSINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6608 guanosine nucleotides degradation PNP GDA NT5C2 XDH SUPEROXIDE RADICALS DEGRADATION%BIOCYC%DETOX1-PWY superoxide radicals degradation CAT SOD2 SOD3 SOD1 MYO< I>-INOSITOL BIOSYNTHESIS%BIOCYC%PWY-2301 myo< i>-inositol biosynthesis ISYNA1 IMPA1 IMPA2 AEROBIC RESPIRATION I (CYTOCHROME C)%BIOCYC%PWY-3781 aerobic respiration I (cytochrome c) MT-ND6 MT-ND4L COX7B NDUFA13 MT-ND4 MT-ND5 NDUFA11 NDUFA12 MT-CO1 COX4I1 NDUFA10 MT-ND2 COX6A1 COXFA4L2 MT-ND3 COX7C MT-ND1 UQCRFS1 COX8A NDUFC2 SDHC NDUFC1 SDHD SDHA SDHB COX6B1 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS4 UQCRC1 NDUFS3 NDUFS2 NDUFS1 COXFA4 MT-CO2 UQCRC2 MT-CO3 NDUFB9 NDUFB8 NDUFB7 NDUFB6 NDUFB10 UQCRB NDUFB11 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 UQCR11 COX7A2 UQCR10 COX5B COX5A UQCRH NDUFV3 CYC1 NDUFV2 NDUFV1 NDUFA9 NDUFA8 NDUFA7 NDUFA6 NDUFA5 NDUFA3 NDUFA2 NDUFA1 COX6C UQCRQ NDUFAB1 MT-CYB DOLICHOL AND DOLICHYL PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6129 dolichol and dolichyl phosphate biosynthesis NUS1 DHRSX SRD5A3 DOLK DHDDS PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-841 purine nucleotides de novo< i> biosynthesis AK2 GMPS AK3 RRM1 AK4 RRM2 AK5 AK7 NME2 PFAS AK8 NME3 ATIC GUK1 NME4 PPAT ADSL NME5 PAICS IMPDH1 NME1 IMPDH2 NME6 ADSS1 RRM2B ADSS2 NME7 GART AK1 NAD SALVAGE PATHWAY IV (FROM NICOTINAMIDE RIBOSIDE)%BIOCYC%PWY3O-4106 NAD salvage pathway IV (from nicotinamide riboside) NMNAT1 NMRK2 NMRK1 NMNAT3 NMNAT2 GABA SHUNT%BIOCYC%GLUDEG-I-PWY GABA shunt GLUD1 GAD1 GLUD2 GAD2 ALDH5A1 GLUL ABAT PENTOSE PHOSPHATE PATHWAY (OXIDATIVE BRANCH)%BIOCYC%OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) G6PD PGLS PGD UBIQUINOL-10 BIOSYNTHESIS (LATE DECARBOXYLATION)%BIOCYC%PWY-5872 ubiquinol-10 biosynthesis (late decarboxylation) COQ2 PDSS2 PDSS1 COQ7 COQ6 COQ5 UBIAD1 COQ4 COQ3 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7228 guanosine nucleotides de novo< i> biosynthesis GMPS RRM1 RRM2 NME2 NME3 NME4 GUK1 NME5 IMPDH1 NME1 IMPDH2 NME6 RRM2B NME7 SERINE AND GLYCINE BIOSYNTHESIS%BIOCYC%SER-GLYSYN-PWY serine and glycine biosynthesis VPS29 SHMT2 PSAT1 SHMT1 PHGDH PSPH PURINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7224 purine deoxyribonucleosides salvage NME7 AK5 NME2 NME3 GUK1 NME4 NME5 DGUOK DCK NME1 NME6 THYROID HORMONE METABOLISM II (VIA CONJUGATION AND OR DEGRADATION)%BIOCYC%PWY-6261 thyroid hormone metabolism II (via conjugation and or degradation) DIO1 DIO2 UGT1A8 SULT1A2 SULT1A1 UGT2B11 GLUTAMINYL-TRNAGLN< SUP> BIOSYNTHESIS VIA TRANSAMIDATION%BIOCYC%PWY-5921 glutaminyl-tRNAgln< sup> biosynthesis via transamidation ASNS GLS2 GLS VITAMIN K-EPOXIDE CYCLE%BIOCYC%PWY-7999 vitamin K-epoxide cycle VKORC1 NQO1 VKORC1L1 GGCX MELATONIN DEGRADATION I%BIOCYC%PWY-6398 melatonin degradation I SULT1A2 POR CYP4X1 CYP2A6 CYP2U1 CYP2S1 CYP1A2 CYP1B1 SULT1A1 CYP2C19 UGT2B11 PURINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7179-1 purine deoxyribonucleosides degradation PNP ADA GLUTATHIONE-MEDIATED DETOXIFICATION I%BIOCYC%PWY-4061 glutathione-mediated detoxification I GSTK1 GSTM3 GSTM2 GSTM1 GSTO2 GSTP1 MGST3 MGST1 MGST2 GSTT2 GSTT1 NAT8 GGT5 GSTA5 GSTA4 GSTA3 GSTA2 ANPEP GSTA1 GSTM5 GSTZ1 TETRAHYDROFOLATE SALVAGE FROM 5,10-METHENYLTETRAHYDROFOLATE%BIOCYC%PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate GART MTHFD1 ICOSAPENTAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8399 icosapentaenoate metabolites biosynthesis LTA4H PTGS2 ALOX5 PUTRESCINE BIOSYNTHESIS I%BIOCYC%PWY-40 putrescine biosynthesis I AZIN2 AGMAT PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS II%BIOCYC%PWY4FS-6 phosphatidylethanolamine biosynthesis II CHKB PCYT2 ETNK2 ETNK1 CEPT1 SELENOI CARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-420 carnosine biosynthesis CARNS1 CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%BIOCYC%PWY66-4 cholesterol biosynthesis III (via desmosterol) SC5D DHCR24 DHCR7 LSS FDFT1 NSDHL HSD17B7 SQLE LBR EBP TM7SF2 KCNH7 PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION%BIOCYC%PWY-7197 pyrimidine deoxyribonucleotide phosphorylation DTYMK NME7 CMPK1 CMPK2 NME2 NME3 NME4 NME5 NME1 NME6 PROTECTIN BIOSYNTHESIS%BIOCYC%PWY-8357 protectin biosynthesis ALOX12 GPX4 ALOX15 L-LYSINE DEGRADATION (PIPECOLATE PATHWAY)%BIOCYC%PWY66-425 L-lysine degradation (pipecolate pathway) AADAT PYCR1 PIPOX CRYM DHTKD1 CHONDROITIN SULFATE DEGRADATION (METAZOA)%BIOCYC%PWY-6573 chondroitin sulfate degradation (metazoa) HYAL1 HYAL4 SPAM1 (S)-RETICULINE BIOSYNTHESIS%BIOCYC%PWY-6133 (S)-reticuline biosynthesis TYR ATP BIOSYNTHESIS%BIOCYC%PWY-7980 ATP biosynthesis ATP6V1G1 ATP6V0B ATP6V0E1 ATP5PD VPS9D1 ATP5PB ATP5F1C ATP5F1D MT-ATP8 ATP5F1E ATP6V1B2 ATP5PO ATP6V0D1 ATP6V0C ATPAF1 ATP6V1A ATP5MC2 ATP5MC3 ATP5MC1 MT-ATP6 ATP5F1A ATP5F1B ATP6V1H ATP6V1E1 ATP5MG ATP6V1D ATP6V1C1 ATP5MF ATP5ME ATP6V1F ATP6V0A1 ATPAF2 ATP5PF FOLATE POLYGLUTAMYLATION%BIOCYC%PWY-2161 folate polyglutamylation FPGS MTHFD1 SHMT2 SHMT1 MTHFD1L L-SERINE BIOSYNTHESIS%BIOCYC%SERSYN-PWY L-serine biosynthesis VPS29 PSAT1 PHGDH PSPH L-ASPARAGINE DEGRADATION I%BIOCYC%ASPARAGINE-DEG1-PWY L-asparagine degradation I ASPG ASRGL1 ITACONATE BIOSYNTHESIS I%BIOCYC%PWY-5750 itaconate biosynthesis I ACOD1 5-AMINOIMIDAZOLE RIBONUCLEOTIDE BIOSYNTHESIS%BIOCYC%PWY-6121 5-aminoimidazole ribonucleotide biosynthesis GART PFAS PPAT PYRIMIDINE RIBONUCLEOSIDES SALVAGE I%BIOCYC%PWY-7193 pyrimidine ribonucleosides salvage I CDA UCK2 UCK1 UCKL1 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%BIOCYC%PWY66-5 superpathway of cholesterol biosynthesis SC5D DHCR24 DHCR7 LSS ACAT2 FDFT1 ACAT1 IDI1 FDPS MVK GGPS1 HMGCS1 IDI2 PMVK MVD HMGCR NSDHL HSD17B7 HMGCS2 SQLE LBR TM7SF2 EBP KCNH7 PUTRESCINE BIOSYNTHESIS III%BIOCYC%PWY-46 putrescine biosynthesis III ARG2 ODC1 PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY0-1295 pyrimidine ribonucleosides degradation CDA UPP2 UPP1 KETOGENESIS%HUMANCYC%REACT_1464.NULL ketogenesis ACAT1 HMGCL HMGCS2 BDH2 BDH1 D-GLUCURONATE DEGRADATION%BIOCYC%PWY-5525 D-glucuronate degradation AKR1A1 CRYL1 DCXR D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6351 D-myo< i>-inositol (1,4,5)-trisphosphate biosynthesis PIP5K1A PIP5K1B PIP5K1C PLCG1 CDIPT PI4KA PLCH1 PI4KB PLCH2 PLCD3 PLCD4 PLCD1 PI4K2B PLCZ1 PIP5KL1 PLCE1 PIP4K2A PIP4K2B PIP4K2C PLCB3 PLCB4 PLCB1 PLCB2 PI4K2A PLCG2 ETHANOL DEGRADATION IV%BIOCYC%PWY66-162 ethanol degradation IV ALDH3A2 ACSS3 ALDH2 ACSS2 ACSS1 CAT CARBON DISULFIDE OXIDATION III (METAZOA)%BIOCYC%PWY-7926 carbon disulfide oxidation III (metazoa) CYP2E1 L-ISOLEUCINE DEGRADATION%BIOCYC%ILEUDEG-PWY L-isoleucine degradation BCKDHA ECHS1 DBT ACAT2 BCKDHB ACAT1 BCAT1 ACADSB DLD HSD17B10 BCAT2 GLYCINE BIOSYNTHESIS%BIOCYC%GLYSYN-ALA-PWY glycine biosynthesis AGXT2 AGXT ARACHIDONATE BIOSYNTHESIS V (8-DETATURASE, MAMMALS)%BIOCYC%PWY-7725 arachidonate biosynthesis V (8-detaturase, mammals) FADS2 ELOVL7 FADS1 SUPERPATHWAY OF GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7835 superpathway of glycosphingolipids biosynthesis ST8SIA2 ST8SIA3 B3GALT4 B3GALT5 GBGT1 B3GNT5 B3GNT2 B4GALT6 B4GALT4 B4GALT2 B4GALT3 B4GALT1 FUT2 FUT1 UGCG B3GALT1 ST3GAL4 ST3GAL5 ST3GAL6 B4GALNT1 A4GALT ST3GAL2 ST3GAL3 B3GALNT1 ST6GAL1 ST8SIA1 HEME DEGRADATION I%BIOCYC%PWY-5874 heme degradation I HMOX1 UGT1A4 HMOX2 BLVRA PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS III%BIOCYC%PWY-6273 phosphatidylethanolamine biosynthesis III PTDSS2 NEOLACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7841 neolacto-series glycosphingolipids biosynthesis ST8SIA2 ST8SIA3 B3GNT5 B3GNT2 B4GALT6 B4GALT4 B4GALT2 B4GALT3 B4GALT1 UGCG ST3GAL4 ST3GAL6 ST6GAL1 GDP-L-FUCOSE BIOSYNTHESIS II (FROM L-FUCOSE)%BIOCYC%PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) FCSK FPGT GDP-L-FUCOSE BIOSYNTHESIS I (FROM GDP-D-MANNOSE)%BIOCYC%PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) GMDS THIAMINE SALVAGE III%BIOCYC%PWY-6898 thiamine salvage III TPK1 THYMINE DEGRADATION%BIOCYC%PWY-6430 thymine degradation DPYS DPYD UPB1 S< I>-METHYL-5'-THIOADENOSINE DEGRADATION%BIOCYC%PWY-6756 S< i>-methyl-5'-thioadenosine degradation MTAP NAD PHOSPHORYLATION AND TRANSHYDROGENATION%BIOCYC%NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and transhydrogenation NNT NADK CHOLINE DEGRADATION%BIOCYC%CHOLINE-BETAINE-ANA-PWY choline degradation CHDH ALDH7A1 ADENINE AND ADENOSINE SALVAGE VI%BIOCYC%PWY-6619 adenine and adenosine salvage VI ADK PLASMALOGEN BIOSYNTHESIS%BIOCYC%PWY-7782 plasmalogen biosynthesis FAR2 CHKB PCYT1B PCYT2 PCYT1A ETNK2 CHKA ETNK1 PEDS1 CEPT1 AGPAT1 SELENOI GNPAT AGPS FAR1 L-DOPA AND L-DOPACHROME BIOSYNTHESIS%BIOCYC%PWY-6481 L-dopa and L-dopachrome biosynthesis TYR L-TRYPTOPHAN DEGRADATION XI (MAMMALIAN, VIA KYNURENINE)%BIOCYC%PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) HAAO GOT2 KMO ACMSD AADAT TDO2 KYNU AFMID KYAT3 DHTKD1 IDO2 ALDH8A1 IDO1 KYAT1 ESTRADIOL BIOSYNTHESIS I (VIA ESTRONE)%BIOCYC%PWY66-380 estradiol biosynthesis I (via estrone) CYP2A6 CYP19A1 HSD17B1 HSD17B7 HSD17B3 HSD17B11 ICOSAPENTAENOATE BIOSYNTHESIS III (8-DESATURASE, MAMMALS)%BIOCYC%PWY-7724 icosapentaenoate biosynthesis III (8-desaturase, mammals) ACSL1 ACSM6 ACSM5 ACSM4 FADS2 ELOVL5 ELOVL7 FADS1 ACSM3 SULFITE OXIDATION%BIOCYC%PWY-5326 sulfite oxidation SUOX HISTAMINE BIOSYNTHESIS%BIOCYC%PWY-6173 histamine biosynthesis HDC GANGLIO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7836 ganglio-series glycosphingolipids biosynthesis B3GALT4 UGCG ST3GAL5 B4GALT6 B4GALNT1 ST3GAL2 ST3GAL3 ST6GAL1 ST8SIA1 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 1 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7832 ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide ABO FUT2 FUT3 B3GALT5 B3GALT1 ST3GAL3 METHYLGLYOXAL DEGRADATION III%BIOCYC%PWY-5453 methylglyoxal degradation III CYP2E1 AKR1B10 AKR1B1 S-ADENOSYL-L-METHIONINE BIOSYNTHESIS%BIOCYC%SAM-PWY S-adenosyl-L-methionine biosynthesis MAT2A MAT1A MAT2B PLASMALOGEN DEGRADATION%BIOCYC%PWY-7783 plasmalogen degradation TMEM86B ENPP2 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY0-162 superpathway of pyrimidine ribonucleotides de novo< i> biosynthesis CAD NME2 CTPS2 NME3 CTPS1 NME4 NME5 DHODH NME1 NME6 NME7 CMPK1 CMPK2 UMPS 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS V (FROM INS(1,3,4)P3)%BIOCYC%PWY-6554 1D-myo< i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) IPPK IPMK ITPK1 GLYCINE SERINE BIOSYNTHESIS%BIOCYC%GLYSYN-PWY glycine serine biosynthesis SHMT2 SHMT1 OLEATE BIOSYNTHESIS%BIOCYC%PWY-5996 oleate biosynthesis SCD FADS6 SCD5 ACOT2 ACOT1 ACOT4 C20 PROSTANOID BIOSYNTHESIS%HUMANCYC%15369 C20 prostanoid biosynthesis CBR1 PTGIS HPGD PTGES2 PTGES3 AKR1C3 PTGR1 PTGR2 PTGS1 HPGDS TBXAS1 PTGDS PTGES PTGS2 3-PHOSPHOINOSITIDE DEGRADATION%BIOCYC%PWY-6368 3-phosphoinositide degradation PIP4P2 PIP4P1 INPPL1 TPTE2 PTEN SACM1L OCRL INPP4A SYNJ2 INPP4B INPP5E INPP5B INPP5F SYNJ1 MTMR3 INPP5D INPP5J MTMR14 INPP5K ULTRA-LONG-CHAIN FATTY ACID BIOSYNTHESIS%BIOCYC%PWY-8041 ultra-long-chain fatty acid biosynthesis HSD17B12 ELOVL4 TECR COENZYME A BIOSYNTHESIS II (EUKARYOTIC)%BIOCYC%PWY-7851 coenzyme A biosynthesis II (eukaryotic) PPCS COASY PPCDC RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-397 resolvin D biosynthesis ALOX12 EPHX3 GPX4 ALOX5 ALOX15 ACETONE DEGRADATION I (TO METHYLGLYOXAL)%BIOCYC%PWY-5451 acetone degradation I (to methylglyoxal) CYP2E1 CYP4X1 CYP2A6 CYP2U1 CYP2S1 ARACHIDONATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8397 arachidonate metabolites biosynthesis PTGIS HPGD PTGES2 PTGES3 PTGR1 PTGR2 PTGS1 HPGDS TBXAS1 PTGDS PTGES LTA4H PTGS2 EPHX3 CYP2D6 CYP2J2 CYP4F2 CYP4F3 ALOX15B DPEP2 GSTM4 GGT5 GPX4 ALOX5 ALOX15 DPEP1 ALOX12 LTC4S PROTEIN CITRULLINATION%BIOCYC%PWY-4921 protein citrullination PADI4 PADI1 PADI6 PADI3 PADI2 L-PHENYLALANINE DEGRADATION I (AEROBIC)%BIOCYC%PHENYLALANINE-DEG1-PWY L-phenylalanine degradation I (aerobic) PAH PHOSPHATIDYLSERINE BIOSYNTHESIS II%BIOCYC%PWY-7506 phosphatidylserine biosynthesis II PTDSS2 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6364 D-myo< i>-inositol (1,3,4)-trisphosphate biosynthesis IPMK INPPL1 PTEN OCRL SYNJ2 ITPKB INPP5B ITPKC MINPP1 INPP5A SYNJ1 INPP5D ITPKA INPP5J INPP5K INOSITOL DIPHOSPHATES BIOSYNTHESIS%BIOCYC%PWY-6369 inositol diphosphates biosynthesis IP6K1 PPIP5K1 IP6K3 IPPK IP6K2 PPIP5K2 IPMK THYRONAMINE AND IODOTHYRONAMINE METABOLISM%BIOCYC%PWY-6688 thyronamine and iodothyronamine metabolism DIO1 DIO2 DIO3 THIOREDOXIN PATHWAY%BIOCYC%THIOREDOX-PWY thioredoxin pathway TXNRD3 TXNRD2 TXNRD1 15-EPI< I>-LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-393 15-epi< i>-lipoxin biosynthesis PTGS2 ALOX5 ACETYL-COA BIOSYNTHESIS FROM CITRATE%BIOCYC%PWY-5172 acetyl-CoA biosynthesis from citrate ACLY KETOLYSIS%HUMANCYC%REACT_59.NULL ketolysis ACAT1 OXCT1 BDH2 BDH1 2'-DEOXY-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-7180 2'-deoxy-α-D-ribose 1-phosphate degradation ALDH3A1 ALDH3B2 ALDH1B1 ALDH3B1 PGM2 DERA ANANDAMIDE LIPOXYGENATION%BIOCYC%PWY-8056 anandamide lipoxygenation ALOX12 ALOX5 ALOX15 L-METHIONINE SALVAGE FROM L-HOMOCYSTEINE%BIOCYC%ADENOSYLHOMOCYSCAT-PWY L-methionine salvage from L-homocysteine MTR BHMT BHMT2 SUPERPATHWAY OF MELATONIN DEGRADATION%BIOCYC%PWY-6402 superpathway of melatonin degradation SULT1A2 POR CYP4X1 MAOA CYP2A6 CYP2U1 CYP2S1 CYP1A2 CYP1B1 SULT1A1 CYP2C19 UGT2B11 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION TO GLUTARYL-COA%BIOCYC%PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA ACMSD DHTKD1 ALDH8A1 GLUTATHIONE-PEROXIDE REDOX REACTIONS%BIOCYC%PWY-4081 glutathione-peroxide redox reactions GPX2 GPX1 GPX3 GSR GPX7 GPX4 NAD SALVAGE%BIOCYC%NAD-BIOSYNTHESIS-III NAD salvage NMNAT1 NMNAT3 NAMPT NMNAT2 HISTAMINE DEGRADATION%BIOCYC%PWY-6181 histamine degradation AOC1 HNMT CDP-DIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-5667 CDP-diacylglycerol biosynthesis LCLAT1 AGPAT3 AGPAT4 GPAM LPCAT4 GPAT4 LPCAT3 GPAT3 GPAT2 CDS2 AGPAT5 CDS1 MBOAT7 MBOAT1 AGPAT1 MBOAT2 ABHD5 AGPAT2 RAPOPORT-LUEBERING GLYCOLYTIC SHUNT%BIOCYC%PWY-6405 Rapoport-Luebering glycolytic shunt MINPP1 BPGM FATTY ACID &ALPHA;-OXIDATION III%BIOCYC%PWY66-388 fatty acid α-oxidation III ALDH3A2 FA2H HACL1 GLUCONEOGENESIS%BIOCYC%PWY66-399 gluconeogenesis PCK1 FBP1 FBP2 BPGM GPI TPI1 MDH1 MDH2 PGAM1 PGAM2 ENO1 ENO2 ENO3 G6PC1 G6PC2 PC GAPDH G6PC3 GAPDHS PGK1 ALDOC ALDOB PGK2 ALDOA PHENYLETHYLAMINE DEGRADATION I%BIOCYC%2PHENDEG-PWY phenylethylamine degradation I AOC2 MAOB ALDH3A2 ALDH2 MAOA AOC3 PENTOSE PHOSPHATE PATHWAY (NON-OXIDATIVE BRANCH)%BIOCYC%NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) RPIA RPE TALDO1 TKT VERY LONG CHAIN FATTY ACID BIOSYNTHESIS II%BIOCYC%PWY-7036 very long chain fatty acid biosynthesis II HSD17B12 TECR ELOVL1 ELOVL7 ARACHIDONATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7592 arachidonate biosynthesis III (6-desaturase, mammals) ACSL1 HSD17B12 ACSM6 ACSBG1 ACSM5 ACSM4 SLC27A2 ACSBG2 ELOVL7 FADS1 FADS2 ELOVL5 ACSM3 D-MYO< I>-INOSITOL (3,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6365 D-myo< i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis IPMK ITPK1 &GAMMA;-GLUTAMYL CYCLE%BIOCYC%PWY-4041 γ-glutamyl cycle GGCT GCLC GSS GGT5 OPLAH GCLM CNDP2 UTP AND CTP DEPHOSPHORYLATION I%BIOCYC%PWY-7185 UTP and CTP dephosphorylation I CTPS2 CTPS1 NTPCR GLYCOGENOLYSIS%BIOCYC%PWY-5941 glycogenolysis HK3 MGAM HKDC1 PYGM PYGL PGM1 GCK HK2 HK1 PGM2 PYGB L-VALINE DEGRADATION%BIOCYC%VALDEG-PWY L-valine degradation BCKDHA ECHS1 DBT BCKDHB BCAT1 DLD ACAD8 ALDH6A1 ABAT BCAT2 HIBADH HIBCH ARG N-END RULE PATHWAY (EUKARYOTIC)%BIOCYC%PWY-7799 Arg N-end rule pathway (eukaryotic) NTAQ1 APEH NTAN1 METAP1 METAP2 ATE1 NAA20 NAA25 ASPIRIN TRIGGERED RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-395 aspirin triggered resolvin D biosynthesis PTGS2 ALOX5 L-ASPARTATE BIOSYNTHESIS%BIOCYC%ASPARTATESYN-PWY L-aspartate biosynthesis GOT1L1 GOT1 OXIDIZED GTP AND DGTP DETOXIFICATION%BIOCYC%PWY-6502 oxidized GTP and dGTP detoxification NUDT1 GDP-GLUCOSE BIOSYNTHESIS II%BIOCYC%PWY-5661-1 GDP-glucose biosynthesis II HK3 HKDC1 PGM1 GCK HK2 HK1 PGM2 MELATONIN DEGRADATION II%BIOCYC%PWY-6399 melatonin degradation II MAOA TRNA SPLICING II%BIOCYC%PWY-7803 tRNA splicing II RTRAF TSEN34 TSEN15 DDX1 RTCB ZBTB8OS FAM98B TSEN2 C2orf49 TSEN54 PYRIMIDINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7199 pyrimidine deoxyribonucleosides salvage TK2 TK1 CDA TYMS DCK PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7184 pyrimidine deoxyribonucleotides de novo< i> biosynthesis DTYMK DUT RRM1 RRM2 NME2 NME3 NME4 NTPCR NME5 TYMS NME1 NME6 RRM2B NME7 L-PROLINE BIOSYNTHESIS%BIOCYC%PROSYN-PWY L-proline biosynthesis PYCR2 ALDH18A1 PYCR1 4-HYDROXY-2-NONENAL DETOXIFICATION%BIOCYC%PWY-7112 4-hydroxy-2-nonenal detoxification GSTA1 GSTP1 GSTA5 GSTA4 GSTA3 PURINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6353 purine nucleotides degradation NT5C3A NT5E NT5C1A PNP NT5C1B GDA NT5C2 XDH IMPDH1 IMPDH2 ADA L-CYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6292 L-cysteine biosynthesis MAT2A MAT1A MAT2B AHCY CBS CTH L-METHIONINE SALVAGE CYCLE%BIOCYC%PWY-7527 L-methionine salvage cycle APIP MRI1 MTAP KYAT1 ENOPH1 MAT2A MAT1A MAT2B SRM ADI1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%BIOCYC%PWY-6363 D-myo< i>-inositol (1,4,5)-trisphosphate degradation INPP1 INPPL1 OCRL SYNJ2 INPP5B INPP5A INPP5F SYNJ1 IMPA1 IMPA2 INPP5J BPNT2 INPP5K 2-METHYL-BRANCHED FATTY ACID &BETA;-OXIDATION%BIOCYC%PWY-8181 2-methyl-branched fatty acid β-oxidation ACADSB BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL BMP Signalling Pathway BMPR1B ACVR2A SKI SMAD4 BMP2 BMPR2 ZFYVE16 LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 leukotriene biosynthesis DPEP1 GGT3P LTC4S LTA4H GSTM4 GGT5 DPEP2 ALOX5 PROGESTERONE BIOSYNTHESIS%BIOCYC%PWY-7299 progesterone biosynthesis HSD3B2 HSD3B1 L-GLUTAMATE BIOSYNTHESIS%BIOCYC%GLUTAMATE-SYN2-PWY L-glutamate biosynthesis GLUD1 GLUD2 RETINOATE BIOSYNTHESIS II%BIOCYC%PWY-6875 retinoate biosynthesis II RBP4 RBP5 RBP1 XDH GLUTATHIONE BIOSYNTHESIS%BIOCYC%GLUTATHIONESYN-PWY glutathione biosynthesis GCLC GSS GCLM DOPAMINE DEGRADATION%BIOCYC%PWY6666-2 dopamine degradation MAOB ALDH3A2 SULT1A3 MAOA COMT MARESIN BIOSYNTHESIS%BIOCYC%PWY-8356 maresin biosynthesis ALOX12 EPHX3 ALOX15 L-ASPARTATE DEGRADATION I%BIOCYC%ASPARTATE-DEG1-PWY L-aspartate degradation I GOT1L1 GOT1 GALA-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7840 gala-series glycosphingolipids biosynthesis ST3GAL5 UGT8 GAL3ST1 SORBITOL DEGRADATION I%BIOCYC%PWY-4101 sorbitol degradation I SORD PYRUVATE FERMENTATION TO (S< I>)-LACTATE%BIOCYC%PWY-5481 pyruvate fermentation to (S< i>)-lactate LDHC LDHB LDHA PUTRESCINE DEGRADATION III%BIOCYC%PWY-0 putrescine degradation III MAOB ALDH3A2 ALDH2 ALDH3A1 ALDH3B2 MAOA ALDH1B1 ALDH3B1 SAT2 SAT1 CREATINE-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6158 creatine-phosphate biosynthesis CKM CKMT1B CKB CKMT2 QUEUOSINE BIOSYNTHESIS II (QUEUINE SALVAGE)%BIOCYC%PWY-8105 queuosine biosynthesis II (queuine salvage) QTRT1 QTRT2 L-LEUCINE DEGRADATION%BIOCYC%LEU-DEG2-PWY L-leucine degradation BCKDHA DBT MCCC2 BCKDHB AUH BCAT1 IVD MCCC1 DLD HMGCLL1 BCAT2 HMGCL GLYCEROL-3-PHOSPHATE SHUTTLE%BIOCYC%PWY-6118 glycerol-3-phosphate shuttle GPD1 L-ASPARAGINE DEGRADATION%BIOCYC%ASPARAGINE-DEG1-PWY-1 L-asparagine degradation ASPG ASRGL1 GOT1 AGA SEROTONIN DEGRADATION%BIOCYC%PWY-6313 serotonin degradation SULT1A2 ALDH3A2 ALDH2 SULT1A3 MAOA ADH1B ADH6 SULT1A1 UGT2B11 ADENOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7219 adenosine ribonucleotides de novo< i> biosynthesis AK2 ADSS2 AK3 AK4 AK5 AK7 AK8 ADSL AK1 ADSS1 ACYL-COA HYDROLYSIS%BIOCYC%PWY-5148 acyl-CoA hydrolysis ACOT9 ACOT8 ACOT7 ANANDAMIDE BIOSYNTHESIS II%BIOCYC%PWY-8053 anandamide biosynthesis II PLAAT3 PLAAT2 PLAAT5 PLAAT4 PLAAT1 L-TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde HAAO KMO TDO2 KYNU AFMID IDO2 IDO1 UDP-&ALPHA;-D-XYLOSE BIOSYNTHESIS%BIOCYC%PWY-4821 UDP-α-D-xylose biosynthesis UGDH UXS1 PHOSPHOLIPASES%BIOCYC%LIPASYN-PWY phospholipases PLAAT3 PLAAT2 PLAAT5 PLCG1 PLAAT4 PLA2G1B PLD4 PLA2G3 PLA2G5 PLD6 PLA2G6 PLCH1 PLD1 PLB1 PLCH2 PLD3 PLCD3 PLD2 PLCD4 OC90 PLCD1 PLA2G2F PLA2G12A PLA2G2D PLA2G4F PLA2G2E PLA2G4D PNPLA8 PLA2G4E PLA2G4B PLA2G4C PLA2G2A PLA2G4A PLA2G10 PLCZ1 PLCE1 PLCB3 PLCB4 PLCB1 PLCB2 PLCG2 PLAAT1 EPOXYSQUALENE BIOSYNTHESIS%BIOCYC%PWY-5670 epoxysqualene biosynthesis FDFT1 SQLE CARDENOLIDE BIOSYNTHESIS%BIOCYC%PWY-6032 cardenolide biosynthesis SRD5A2 SRD5A1 CHOLESTEROL BIOSYNTHESIS I%BIOCYC%PWY66-341 cholesterol biosynthesis I SC5D DHCR24 DHCR7 LSS FDFT1 NSDHL HSD17B7 SQLE LBR EBP TM7SF2 KCNH7 OPHTHALMATE BIOSYNTHESIS%BIOCYC%PWY-8043 ophthalmate biosynthesis GOT1 GCLC GSS GCLM COENZYME A BIOSYNTHESIS%BIOCYC%COA-PWY-1 coenzyme A biosynthesis PANK2 PANK3 PANK1 PPCS COASY PPCDC SUCROSE DEGRADATION%BIOCYC%PWY66-373 sucrose degradation TKFC SI KHK ALDOC ALDOB TPI1 ALDOA PRPP BIOSYNTHESIS%BIOCYC%PWY0-662 PRPP biosynthesis PRPS2 PRPS1 PRPS1L1 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE%BIOCYC%PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage DTYMK NME2 NME3 NME4 NME5 TYMS DCK NME1 NME6 NME7 TK2 CMPK1 TK1 CMPK2 CDA PHOSPHATIDYLCHOLINE BIOSYNTHESIS%BIOCYC%PWY3O-450 phosphatidylcholine biosynthesis CHKB PCYT1B PCYT1A CHPT1 CHKA CEPT1 SUPERPATHWAY OF L-TRYPTOPHAN UTILIZATION%BIOCYC%PWY66-401 superpathway of L-tryptophan utilization MAOB ALDH2 MAOA ADH1B ADH6 NMNAT1 NMNAT3 TPH2 NMNAT2 TPH1 DDC AANAT ASMT CYP2A6 AKR1A1 HAAO GCDH ECHS1 KMO ACAT2 ACMSD ACAT1 TDO2 KYNU AFMID ALDH3A2 SULT1A3 DHTKD1 IDO2 QPRT ALDH8A1 NADSYN1 IDO1 SULT1A1 UGT2B11 SULT1A2 POR CYP4X1 CYP2U1 CYP2S1 CYP1A2 CYP1B1 CYP2C19 FATTY ACID &BETA;-OXIDATION (PEROXISOME)%BIOCYC%PWY66-391 fatty acid β-oxidation (peroxisome) ACAA1 HADH ACSBG1 ECHS1 SLC27A2 ACSBG2 HSD17B10 SCP2 ACOX2 ACOX1 EHHADH HSD17B4 L-TRYPTOPHAN DEGRADATION VIA TRYPTAMINE%BIOCYC%PWY-6307 L-tryptophan degradation via tryptamine AKR1A1 MAOB ALDH3A2 DDC TRNA CHARGING%BIOCYC%TRNA-CHARGING-PWY tRNA charging VARS1 RARS2 HARS1 RARS1 MARS2 MARS1 DARS2 HARS2 DARS1 WARS1 WARS2 GARS1 LARS2 SARS1 SARS2 EPRS1 LARS1 TARS2 TARS3 FARSA CARS1 CARS2 TARS1 FARSB AARS1 AARS2 KARS1 PARS2 YARS1 YARS2 FARS2 NARS1 QARS1 NARS2 IARS2 IARS1 VARS2 EARS2 PYRIDOXAL 5'-PHOSPHATE SALVAGE%BIOCYC%PLPSAL-PWY-1 pyridoxal 5'-phosphate salvage PDXK PNPO N< I>-ACETYLGLUCOSAMINE DEGRADATION I%BIOCYC%GLUAMCAT-PWY N< i>-acetylglucosamine degradation I AMDHD2 GNPDA1 GNPDA2 4-HYDROXYBENZOATE BIOSYNTHESIS%BIOCYC%PWY-5754 4-hydroxybenzoate biosynthesis TAT SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE%BIOCYC%PWY66-409 superpathway of purine nucleotide salvage AK2 GMPS AK3 RRM1 AK4 RRM2 AK5 AK7 NME2 AK8 NME3 GUK1 NME4 ADSL NME5 IMPDH1 NME1 IMPDH2 NME6 ADSS1 RRM2B ADSS2 NME7 ADK APRT HPRT1 PNP AK1 ADA SPHINGOLIPID BIOSYNTHESIS (MAMMALS)%BIOCYC%PWY-7277 sphingolipid biosynthesis (mammals) KDSR SPTSSA CERS1 SPTLC1 SPTLC2 SPTLC3 DEGS1 PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP%BIOCYC%PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP DTYMK RRM1 RRM2 DCTD NME2 NME3 NME4 NTPCR NME5 TYMS NME1 NME6 RRM2B NME7 UTP AND CTP DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7176 UTP and CTP de novo< i> biosynthesis NME7 CMPK1 CMPK2 NME2 CTPS2 NME3 CTPS1 NME4 NME5 NME1 NME6 SUPERPATHWAY OF CHOLINE DEGRADATION TO L-SERINE%BIOCYC%PWY66-414 superpathway of choline degradation to L-serine DMGDH CHDH ALDH7A1 SHMT2 SHMT1 BHMT TCA CYCLE%BIOCYC%PWY66-398 TCA cycle FH SDHC IDH3G DLST SDHD SDHA CS DLD SDHB SUCLA2 IDH3B OGDH SUCLG2 SUCLG1 ACO2 MDH1 IDH3A MDH2 N< I>1< SUP>-METHYL-N< I>3< SUP>-AMINOCARBOXYPROPYL-PSEUDOURIDINE-MODIFIED RRNA BIOSYNTHESIS%BIOCYC%PWY-8341 N< i>1< sup>-methyl-N< i>3< sup>-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis EMG1 TSR3 FATTY ACID &BETA;-OXIDATION%BIOCYC%FAO-PWY fatty acid β-oxidation HADH HADHB ACSBG1 HADHA ECHS1 ACAA2 ECI1 SLC27A2 ACSBG2 HSD17B10 SCP2 CERAMIDE DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY3DJ-12 ceramide de novo< i> biosynthesis KDSR SPTSSA CERS1 SPTLC1 SPTLC2 SPTLC3 DEGS1 ARACHIDONATE BIOSYNTHESIS IV (8-DETATURASE)%BIOCYC%PWY-7601 arachidonate biosynthesis IV (8-detaturase) ELOVL7 ERYTHRITOL BIOSYNTHESIS II%BIOCYC%PWY-8373 erythritol biosynthesis II ADH1C ADH1B SORD LACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7839 lacto-series glycosphingolipids biosynthesis FUT2 B3GALT5 UGCG B3GNT5 B3GALT1 ST3GAL5 B4GALT6 ST6GAL1 L-SERINE DEGRADATION%BIOCYC%SERDEG-PWY L-serine degradation SDSL TETRAHYDROPTERIDINE RECYCLING%BIOCYC%PWY-8099 tetrahydropteridine recycling PCBD1 PCBD2 SPERMIDINE BIOSYNTHESIS%BIOCYC%BSUBPOLYAMSYN-PWY spermidine biosynthesis SRM TETRAHYDROBIOPTERIN DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-5663 tetrahydrobiopterin de novo< i> biosynthesis GCH1 SPR PTS L-TRYPTOPHAN DEGRADATION (KYNURENINE PATHWAY)%BIOCYC%TRYPTOPHAN-DEGRADATION-1 L-tryptophan degradation (kynurenine pathway) HAAO GCDH ECHS1 KMO ACAT2 ACMSD ACAT1 TDO2 KYNU AFMID DHTKD1 IDO2 ALDH8A1 IDO1 PROTEIN O< I>-[N< I>-ACETYL]-GLUCOSYLATION%BIOCYC%PWY-7437 protein O< i>-[N< i>-acetyl]-glucosylation OGA OGT CYTOCHROME C< I> BIOGENESIS%BIOCYC%PWY-8145 cytochrome c< i> biogenesis HCCS RETINOATE BIOSYNTHESIS I%BIOCYC%PWY-6872 retinoate biosynthesis I ALDH1A3 SDR16C5 ALDH1A2 ALDH1A1 RDH16 RBP4 RBP5 RBP1 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 2 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7831 ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide ST8SIA2 FUT6 FUT5 FUT9 CHST1 B4GALT2 B4GALT3 B4GALT1 ABO FUT3 FUT1 ST3GAL4 ST3GAL3 CMP PHOSPHORYLATION%BIOCYC%PWY-7205 CMP phosphorylation NME7 CMPK1 CMPK2 NME2 NME3 NME4 NME5 NME1 NME6 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7209 superpathway of pyrimidine ribonucleosides degradation CDA DPYS DPYD UPP2 UPP1 UPB1 THYROID HORMONE METABOLISM I (VIA DEIODINATION)%BIOCYC%PWY-6260 thyroid hormone metabolism I (via deiodination) DIO1 DIO2 DIO3 ICOSAPENTAENOATE BIOSYNTHESIS II (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7049 icosapentaenoate biosynthesis II (6-desaturase, mammals) ACSL1 ACSM6 ACSM5 ACSM4 FADS2 ELOVL5 FADS1 ACSM3 I ANTIGEN AND I ANTIGEN BIOSYNTHESIS%BIOCYC%PWY-7837 i antigen and I antigen biosynthesis B4GALT3 B4GALT1 B3GNT2 GCNT2 GCNT3 B4GALT2 FATTY ACID &BETA;-OXIDATION (UNSATURATED, ODD NUMBER)%BIOCYC%PWY-5137 fatty acid β-oxidation (unsaturated, odd number) ECI1 ECI2 GLYCOLYSIS%BIOCYC%PWY66-400 glycolysis BPGM PKLR GPI PFKL TPI1 PKM PFKM PFKP PGAM1 PGAM2 ENO1 ENO2 ENO3 GAPDH GAPDHS PGK1 ALDOC ALDOB PGK2 ALDOA HK3 HKDC1 GCK HK2 HK1 HYDROGEN SULFIDE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY66-426 hydrogen sulfide biosynthesis II (mammalian) CBS CTH HUMAN MILK OLIGISACCHARIDES BIOSYNTHESIS%BIOCYC%PWY-8459 human milk oligisaccharides biosynthesis B4GALT1 LALBA FUT2 ST6GALNAC6 FUT3 B3GALT5 B3GNT2 B4GALT4 GCNT3 ST3GAL3 ST6GAL1 B4GALT2 INOSINE 5'-PHOSPHATE DEGRADATION%BIOCYC%PWY-5695 inosine 5'-phosphate degradation NT5E PNP NT5C2 XDH IMPDH1 IMPDH2 HEME BIOSYNTHESIS FROM UROPORPHYRINOGEN-III I%BIOCYC%HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I FECH UROD CPOX PPOX MITOCHONDRIAL L-CARNITINE SHUTTLE%BIOCYC%PWY-6111 mitochondrial L-carnitine shuttle CPT1A CPT2 SLC25A20 CPT1C CPT1B EUMELANIN BIOSYNTHESIS%BIOCYC%PWY-6498 eumelanin biosynthesis DCT TRPC1 TYR TYRP1 FATTY ACID BIOSYNTHESIS INITIATION (MITOCHONDRIA)%BIOCYC%PWY66-429 fatty acid biosynthesis initiation (mitochondria) ACSF3 MCAT NDUFAB1 OXSM ANANDAMIDE DEGRADATION%BIOCYC%PWY6666-1 anandamide degradation FAAH FAAH2 FORMALDEHYDE OXIDATION II (GLUTATHIONE-DEPENDENT)%ECOCYC%PWY-1801 formaldehyde oxidation II (glutathione-dependent) ESD ADH5 GLOBO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7838 globo-series glycosphingolipids biosynthesis FUT2 B3GALT5 FUT1 UGCG GBGT1 B4GALT6 A4GALT ST3GAL2 B3GALNT1 TREHALOSE DEGRADATION%BIOCYC%PWY0-1182 trehalose degradation HK3 TREH GCK HK2 HK1 LINOLEATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8395 linoleate metabolites biosynthesis EPHX3 CYP2C9 EPHX2 EPHX1 EPHX4 THE VISUAL CYCLE I (VERTEBRATES)%BIOCYC%PWY-6861 the visual cycle I (vertebrates) RBP4 RBP5 RBP1 RDH8 DHRS3 RLBP1 RPE65 DHRS4 RBP2 RDH12 DHRS9 RBP3 RDH11 RDH10 RDH5 LRAT ANDROGEN BIOSYNTHESIS%BIOCYC%PWY66-378 androgen biosynthesis HSD3B2 HSD3B1 AKR1C3 CYP17A1 HSD17B3 SRD5A2 SRD5A1 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7221 guanosine ribonucleotides de novo< i> biosynthesis NME7 GMPS NME2 NME3 GUK1 NME4 NME5 IMPDH1 IMPDH2 NME1 NME6 RETINOL BIOSYNTHESIS%BIOCYC%PWY-6857 retinol biosynthesis RBP4 RBP5 RBP1 RDH8 DHRS3 DHRS4 RBP2 RDH12 DHRS9 RDH11 RDH10 LRAT CES5A CES4A LIPC BCO1 CES2 PNLIP CES1 DOCOSAHEXAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8400 docosahexaenoate metabolites biosynthesis ALOX12 PTGS2 EPHX3 CYP2D6 GPX4 ALOX5 ALOX15 3-PHOSPHOINOSITIDE BIOSYNTHESIS%BIOCYC%PWY-6352 3-phosphoinositide biosynthesis PIP5K1A PIP5K1B PIP5K1C CDIPT FIG4 PIKFYVE PI4KA PI4KB PI4K2B PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B PIP5KL1 PIP4K2B SACM1L PIK3CA PIK3C3 PI4K2A PIK3R4 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%BIOCYC%PWY-5514 UDP-N< i>-acetyl-D-galactosamine biosynthesis II HK3 GALE PGM3 HKDC1 GNPNAT1 UAP1 GCK HK2 HK1 GPI GNPDA1 GNPDA2 4-AMINOBUTANOATE DEGRADATION I%BIOCYC%PWY-6535 4-aminobutanoate degradation I ALDH5A1 ABAT CMP-2-KETO-3-DEOXY-D-GLYCERO< I>-D-GALACTO< I>-NONONATE BIOSYNTHESIS%BIOCYC%PWY-6140 CMP-2-keto-3-deoxy-D-glycero< i>-D-galacto< i>-nononate biosynthesis HKDC1 L-CYSTEINE DEGRADATION I%BIOCYC%CYSTEINE-DEG-PWY L-cysteine degradation I CDO1 GOT1 STEARATE BIOSYNTHESIS%BIOCYC%PWY-5972 stearate biosynthesis ACSL1 HSD17B12 ACSBG1 ELOVL6 SLC27A2 ACSBG2 ACOT2 ELOVL7 ACOT7 ACOT1 ACOT4 &BETA;-ALANINE DEGRADATION%BIOCYC%BETA-ALA-DEGRADATION-I-PWY β-alanine degradation ABAT TRANS< I>-4-HYDROXY-L-PROLINE DEGRADATION%BIOCYC%HYDROXYPRODEG-PWY trans< i>-4-hydroxy-L-proline degradation ALDH4A1 GOT2 HOGA1 PRODH2 &ALPHA;-TOCOPHEROL DEGRADATION%BIOCYC%PWY-6377 α-tocopherol degradation CYP4F2 DOCOSAHEXAENOATE BIOSYNTHESIS IV (4-DESATURASE, MAMMALS)%BIOCYC%PWY-7727 docosahexaenoate biosynthesis IV (4-desaturase, mammals) HSD17B12 FADS2 ELOVL5 ELOVL2 LANOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6132 lanosterol biosynthesis LSS SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%BIOCYC%PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism ACSL1 ACSBG1 SLC27A2 PTGR1 ACSBG2 ASAH1 ASAH2 SPHK2 SPHK1 SGPP2 SGPP1 ACER2 ACER1 PURINE RIBONUCLEOSIDES DEGRADATION TO RIBOSE-1-PHOSPHATE%BIOCYC%PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate PNP PGM2 ADA PYRIMIDINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7181 pyrimidine deoxyribonucleosides degradation TYMP CDA UPP2 UPP1 D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%BIOCYC%PWY-6367 D-myo< i>-inositol-5-phosphate metabolism PLCG1 PIP4P2 PIP4P1 PLCZ1 PLCE1 PIP4K2A PLCH1 PLCH2 PIP4K2C PLCD3 PLCD4 PLCB3 PLCD1 PLCB4 PLCB1 PLCB2 MTMR3 MTMR14 PLCG2 ALLOPREGNANOLONE BIOSYNTHESIS%BIOCYC%PWY-7455 allopregnanolone biosynthesis AKR1C1 AKR1C2 AKR1C4 AKR1C3 SRD5A2 SRD5A1 SPERMINE BIOSYNTHESIS%BIOCYC%ARGSPECAT-PWY spermine biosynthesis SMS FOLATE TRANSFORMATIONS I%BIOCYC%PWY-2201-1 folate transformations I MTR MTHFD1 ALDH1L1 MTHFD2 SHMT2 MTHFD2L MTHFR SHMT1 MTHFS ALDH1L2 MTHFD1L GLYCEROL DEGRADATION%BIOCYC%PWY-4261 glycerol degradation GK5 GK GK3 GK2 D-MANNOSE DEGRADATION%BIOCYC%MANNCAT-PWY-1 D-mannose degradation MPI L-METHIONINE DEGRADATION%BIOCYC%METHIONINE-DEG1-PWY L-methionine degradation MAT2A MAT1A MAT2B AHCY ADENINE AND ADENOSINE SALVAGE III%BIOCYC%PWY-6609 adenine and adenosine salvage III PNP HPRT1 ADA REACTIVE OXYGEN SPECIES DEGRADATION%BIOCYC%DETOX1-PWY-1 reactive oxygen species degradation GPX6 GPX2 GPX5 GPX1 GPX8 GPX3 GPX7 CAT SOD2 SOD3 SOD1 ADENOSINE NUCLEOTIDES DEGRADATION%BIOCYC%SALVADEHYPOX-PWY adenosine nucleotides degradation NT5C3A NT5E NT5C1A PNP NT5C1B NT5C2 XDH ADA ACETONE DEGRADATION III (TO PROPANE-1,2-DIOL)%BIOCYC%PWY-7466 acetone degradation III (to propane-1,2-diol) CYP2E1 AKR1B10 CYP4X1 CYP2A6 CYP2U1 CYP2S1 L-CARNITINE BIOSYNTHESIS%BIOCYC%PWY-6100 L-carnitine biosynthesis TMLHE BBOX1 ALDH9A1 SHMT1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY-6362 1D-myo< i>-inositol hexakisphosphate biosynthesis II (mammalian) IPMK INPPL1 OCRL ITPK1 SYNJ2 ITPKB INPP5B ITPKC INPP5A SYNJ1 IPPK INPP5D ITPKA INPP5J INPP5K LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-392 lipoxin biosynthesis ALOX12 ALOX15B GPX4 ALOX5 ALOX15 TRIACYLGLYCEROL DEGRADATION%BIOCYC%LIPAS-PWY triacylglycerol degradation PNLIPRP2 DAGLA LPL CEL LIPF LIPE LIPG PNPLA3 PNPLA4 DAGLB PNLIPRP3 PNPLA2 LIPC PNLIP CMP-N< I>-ACETYLNEURAMINATE BIOSYNTHESIS I (EUKARYOTES)%BIOCYC%PWY-6138 CMP-N< i>-acetylneuraminate biosynthesis I (eukaryotes) NANP CMAS NANS GNE CARDIOLIPIN BIOSYNTHESIS%BIOCYC%PWY-5269 cardiolipin biosynthesis PGS1 PTPMT1 CRLS1 L-DOPA DEGRADATION%BIOCYC%PWY-6334 L-dopa degradation COMT CREATINE BIOSYNTHESIS%BIOCYC%GLYCGREAT-PWY creatine biosynthesis GAMT GATM UDP-&ALPHA;-D-GLUCURONATE BIOSYNTHESIS (FROM UDP-GLUCOSE)%BIOCYC%PWY-7346 UDP-α-D-glucuronate biosynthesis (from UDP-glucose) UGDH GUANOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7226 guanosine deoxyribonucleotides de novo< i> biosynthesis RRM2B NME7 RRM1 RRM2 NME2 NME3 NME4 NME5 NME1 NME6 FRUCTOSE 2,6-BISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY66-423 fructose 2,6-bisphosphate biosynthesis PFKFB2 PFKFB1 PFKFB4 TIGAR PFKFB3 GERANYLGERANYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5120 geranylgeranyl diphosphate biosynthesis GGPS1 DTMP DE NOVO< I> BIOSYNTHESIS (MITOCHONDRIAL)%BIOCYC%PWY66-385 dTMP de novo< i> biosynthesis (mitochondrial) DHFR2 SHMT2 TYMS ADENOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7227 adenosine deoxyribonucleotides de novo< i> biosynthesis RRM2B NME7 RRM1 RRM2 NME2 NME3 NME4 NME5 NME1 NME6 NAD BIOSYNTHESIS FROM 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde NMNAT1 NMNAT3 NMNAT2 QPRT NADSYN1 HEME A< I> BIOSYNTHESIS%BIOCYC%PWY-7856 heme a< i> biosynthesis COX10 MRNA CAPPING I%BIOCYC%PWY-7375 mRNA capping I RNGTT RNMT DI-HOMO-&GAMMA;-LINOLENATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8396 di-homo-γ-linolenate metabolites biosynthesis CBR1 PHOSPHATIDYLSERINE BIOSYNTHESIS I%BIOCYC%PWY-7501 phosphatidylserine biosynthesis I PTDSS1 (4Z,7Z,10Z,13Z,16Z)-DOCOSA-4,7,10,13,16-PENTAENOATE BIOSYNTHESIS II (4-DESATURASE)%BIOCYC%PWY-7728 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase) HSD17B12 FADS2 ELOVL5 ELOVL7 ELOVL2 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS I%BIOCYC%PWY-5512 UDP-N< i>-acetyl-D-galactosamine biosynthesis I GALE TERMINAL O< I>-GLYCANS RESIDUES MODIFICATION (VIA TYPE 2 PRECURSOR DISACCHARIDE)%BIOCYC%PWY-7434 terminal O< i>-glycans residues modification (via type 2 precursor disaccharide) B4GALT3 ST8SIA2 B4GALT1 ST6GAL2 ST3GAL4 B3GNT2 GCNT2 GCNT3 ST3GAL3 ST6GAL1 B4GALT2 ETHANOL DEGRADATION III%BIOCYC%PWY66-161 ethanol degradation III CYP2E1 CYP2G1P ALDH3A2 ACSS3 ALDH2 ACSS2 ACSS1 ETHANOL DEGRADATION II%BIOCYC%PWY66-21 ethanol degradation II ALDH3A2 ACSS3 ALDH2 ACSS2 ACSS1 ADH1B 2-OXOBUTANOATE DEGRADATION%BIOCYC%PWY-5130 2-oxobutanoate degradation BCKDHA DBT MCEE BCKDHB PCCA PCCB MMUT DLD LACTOSE DEGRADATION III%BIOCYC%BGALACT-PWY lactose degradation III GLB1 LCT GLB1L3 NICOTINE DEGRADATION IV%BIOCYC%PWY66-201 nicotine degradation IV CYP2G1P UGT1A4 FMO2 FMO3 FMO4 UGT2B11 FMO5 AOX1 FMO6P CYP4X1 CYP2A6 CYP2U1 CYP2S1 D-GALACTOSE DEGRADATION V (LELOIR PATHWAY)%BIOCYC%PWY66-422 D-galactose degradation V (Leloir pathway) GALE GALT GALM GALK1 PGM1 PGM2 UDP-N< I>-ACETYL-D-GLUCOSAMINE BIOSYNTHESIS II%BIOCYC%UDPNACETYLGALSYN-PWY UDP-N< i>-acetyl-D-glucosamine biosynthesis II HK3 PGM3 HKDC1 GNPNAT1 UAP1 GFPT2 GFPT1 GCK HK2 HK1 GPI L-ALANINE BIOSYNTHESIS%BIOCYC%ALANINE-SYN2-PWY L-alanine biosynthesis GPT2 GPT INOSINE-5'-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6124 inosine-5'-phosphate biosynthesis ATIC ADSL PAICS L-LYSINE DEGRADATION (SACCHAROPINE PATHWAY)%BIOCYC%LYSINE-DEG1-PWY L-lysine degradation (saccharopine pathway) AADAT ALDH7A1 AASS DHTKD1 L-SELENOCYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6281 L-selenocysteine biosynthesis SEPSECS SEPHS1 SEPHS2 PSTK SARS1 SARS2 FATTY ACID &ALPHA;-OXIDATION%BIOCYC%PWY66-387 fatty acid α-oxidation SLC27A2 ALDH3A2 PHYH HACL1 ACSM1 GLUTAMINE BIOSYNTHESIS%BIOCYC%GLNSYN-PWY glutamine biosynthesis GLUL TRANS, TRANS< I>-FARNESYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5123 trans, trans< i>-farnesyl diphosphate biosynthesis FDPS GGPS1 THIO-MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-5963 thio-molybdenum cofactor biosynthesis MOCOS WYBUTOSINE BIOSYNTHESIS%BIOCYC%PWY-7283 wybutosine biosynthesis TYW1 LCMT2 TYW3 ANANDAMIDE BIOSYNTHESIS I%BIOCYC%PWY-8051 anandamide biosynthesis I PLAAT2 GDE1 PLAAT5 NAPEPLD PLA2G1B ENPP2 PLAAT1 VALPROATE &BETA;-OXIDATION%BIOCYC%PWY-8182 valproate β-oxidation ECHS1 ACAT2 ACAT1 ACADSB ACSM1 NAD DE NOVO< I> BIOSYNTHESIS%BIOCYC%NADSYN-PWY NAD de novo< i> biosynthesis HAAO NMNAT1 KMO TDO2 NMNAT3 KYNU NMNAT2 AFMID IDO2 QPRT NADSYN1 IDO1 LONG-CHAIN FATTY ACID ACTIVATION%BIOCYC%PWY-5143 long-chain fatty acid activation ACSL1 ACSBG1 ACSL3 SLC27A2 ACSBG2 THIOSULFATE DISPROPORTIONATION IV (RHODANESE)%BIOCYC%PWY-5350 thiosulfate disproportionation IV (rhodanese) TST 2-ARACHIDONOYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-8052 2-arachidonoylglycerol biosynthesis PLCB1 DDHD1 DAGLA DAGLB ARSENIC DETOXIFICATION (MAMMALS)%BIOCYC%PWY-4202 arsenic detoxification (mammals) HEMK2 SLC34A2 PNP TRMT112 SLC20A2 SLC20A1 AQP9 SLC2A1 AQP7 BUPROPION DEGRADATION%BIOCYC%PWY66-241 bupropion degradation CYP4X1 CYP2A6 CYP2U1 CYP2S1 CYP2B6 PROTEIN S< I>-NITROSYLATION AND DENITROSYLATION%BIOCYC%PWY-7798 protein S< i>-nitrosylation and denitrosylation ADH5 UDP-&ALPHA;-D-GLUCOSE BIOSYNTHESIS I%BIOCYC%PWY-7343 UDP-α-D-glucose biosynthesis I UGP2 PGM1 PGM2 ASPIRIN TRIGGERED RESOLVIN E BIOSYNTHESIS%BIOCYC%PWY66-394 aspirin triggered resolvin E biosynthesis LTA4H PTGS2 ALOX5 ORNITHINE DE NOVO < I> BIOSYNTHESIS%BIOCYC%ARGININE-SYN4-PWY ornithine de novo < i> biosynthesis ALDH18A1 SULFATE ACTIVATION FOR SULFONATION%BIOCYC%PWY-5340 sulfate activation for sulfonation PAPSS2 PAPSS1 GDP-MANNOSE BIOSYNTHESIS%BIOCYC%PWY-5659 GDP-mannose biosynthesis GMPPB PMM1 PMM2 GMPPA GPI MPI CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%BIOCYC%PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) SC5D DHCR24 DHCR7 LSS FDFT1 NSDHL HSD17B7 SQLE LBR EBP TM7SF2 KCNH7 UREA CYCLE%BIOCYC%PWY-4984 urea cycle CPS1 ASL ASS1 OTC GLYCINE BETAINE DEGRADATION II (MAMMALIAN)%BIOCYC%PWY-3661-1 glycine betaine degradation II (mammalian) DMGDH SHMT2 SHMT1 BHMT SULFIDE OXIDATION IV (METAZOA)%BIOCYC%PWY-7927 sulfide oxidation IV (metazoa) TST SQOR SUOX HEME BIOSYNTHESIS%BIOCYC%PWY-5920 heme biosynthesis HMBS FECH UROD CPOX PPOX ALAD ALAS2 ALAS1 UROS PROPANOYL COA DEGRADATION I%BIOCYC%PROPIONMET-PWY propanoyl CoA degradation I MCEE PCCA PCCB MMUT L-THREONINE DEGRADATION%BIOCYC%PWY66-428 L-threonine degradation SDS BCKDHA DBT BCKDHB SDSL DLD GUANINE AND GUANOSINE SALVAGE%BIOCYC%PWY-6620 guanine and guanosine salvage PNP HPRT1 CITRULLINE-NITRIC OXIDE CYCLE%BIOCYC%PWY-4983 citrulline-nitric oxide cycle NOS2 NOS3 NOS1 ASL ASS1 SUPERPATHWAY OF METHIONINE DEGRADATION%BIOCYC%PWY-5328 superpathway of methionine degradation BCKDHA DBT CDO1 BCKDHB MCEE PCCA PCCB MMUT DLD BHMT BHMT2 SUOX MTR GOT1 MAT2A MAT1A MAT2B AHCY CBS CTH TETRAPYRROLE BIOSYNTHESIS%BIOCYC%PWY-5189 tetrapyrrole biosynthesis HMBS ALAD ALAS2 ALAS1 UROS MEVALONATE PATHWAY%BIOCYC%PWY-922 mevalonate pathway IDI1 ACAT2 MVK ACAT1 HMGCS1 IDI2 PMVK MVD HMGCR HMGCS2 TAURINE BIOSYNTHESIS II%BIOCYC%PWY-7850 taurine biosynthesis II PPCS FMO1 ADO ASCORBATE RECYCLING (CYTOSOLIC)%BIOCYC%PWY-6370 ascorbate recycling (cytosolic) GSTO1 GLRX DIACYLGLYCEROL AND TRIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%TRIGLSYN-PWY diacylglycerol and triacylglycerol biosynthesis LCLAT1 AGPAT3 AGPAT4 GPAM LPCAT4 GPAT4 LPCAT3 GPAT3 GPAT2 MOGAT3 PLPPR2 PLPPR3 PLPPR4 MOGAT1 DGAT2 DGAT1 PLPP4 PLPP3 PLPP2 PLPP1 AGPAT1 AGPAT5 MBOAT7 MBOAT1 MBOAT2 ABHD5 AGPAT2 FLAVIN BIOSYNTHESIS%HUMANCYC%11070 flavin biosynthesis FLAD1 RFK D-MYO< I>-INOSITOL (1,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6366 D-myo< i>-inositol (1,4,5,6)-tetrakisphosphate biosynthesis MINPP1 IPMK ITPK1 CATECHOLAMINE BIOSYNTHESIS%BIOCYC%PWY66-301 catecholamine biosynthesis PNMT TH DBH DDC 7-(3-AMINO-3-CARBOXYPROPYL)-WYOSINE BIOSYNTHESIS%BIOCYC%PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis TYW1 TYW3 TAURINE BIOSYNTHESIS I%BIOCYC%PWY-5331 taurine biosynthesis I CDO1 FMO1 CSAD ADENINE AND ADENOSINE SALVAGE I%BIOCYC%P121-PWY adenine and adenosine salvage I APRT MALATE-ASPARTATE SHUTTLE%BIOCYC%MALATE-ASPARTATE-SHUTTLE-PWY malate-aspartate shuttle MDH2 GOT1 MDH1 ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin HEL2 RTKN IRS1 ITGB4 HEL113 PIK3CD LAMC2 LAMC1 MYLK3 YWHAQ CASP3 HEL-S-1 RAC1 EPHB2 DST RPSA PRKCA YWHAZ PIK3CA ITGA6 MET PLEC COL17A1 LAMA5 CD151 SHC1 SRC LAMA3 PIK3R3 PIK3R2 MST1R PIK3R1 NTN1 EGFR PAK1 ERBB2 EIF4EBP1 CLCA1 FYN SFN EIF4E SMAD2 YES1 LAMB3 LAMB2 BAD ERBIN LAMB1 PTPN11 MTOR EIF6 ARHA GRB2 TP73 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR AndrogenReceptor FOXA1 RB1 CCNH AHR HEL-S-89n HEL-S-125m UXT CCND3 KAT5 CCND1 ZMIZ1 ZMIZ2 EP300 KAT7 GTF2F1 GTF2F2 RUNX2 TLE5 PIAS1 CDC25B CCNE1 CDC37 PRKD1 IL6ST SF1 PXN PIK3R1 HEL-S-67p BRINP1 BAG1 LPXN PATZ1 MAGEA11 JUN SMAD4 POU2F1 UBE2I XRCC5 NONO PA2G4 NR0B2 CDK9 CDK7 SP1 MDM2 TCF4 RBAK GSK3B TGFB1I1 FHL2 PTEN EFCAB6 BRCA1 CASP8 SIN3A CASP3 TRIM68 RAC3 NELFCD APPL1 PELP1 TGIF1 NCOA1 HEL-S-102 PARP1 NCOA6 PRMT1 HEL-S-72p ETV5 SENP1 NCOR2 KAT2B SLC25A4 CEBPA DDC TMF1 HDAC1 SRC RCHY1 RNF4 NR2C2 HEL-S-99n EGFR RELA PSMC3IP NSD2 FLNA PAK6 SRY SPDEF SVIL STAT3 RANBP9 PNRC1 CTNNB1 STUB1 VIP RAN BDNF%IOB%BDNF BDNF MAPK3 SHC4 NTRK1 GSK3B NTRK2 IRS1 SHC1 MAPK9 MAPK8 MAPK7 PTK2B MAPK1 FOXO3A PLCG1 RAF1 CCR1%IOB%CCR1 CCR1 PXN MAPK14 NFKB1 RELA CREB3 ZAP70 GNA14 CCL8 CCL7 CCL5 CCL4 CCL3 PTK2B MAPK1 CCL16 CCL26 MAPK3 CCL15 CCR1 CCL14 CCL23 SRC STAT1 CCL3L3 CCR5%IOB%CCR5 CCR5 CCL14 CCL13 CCL11 C5AR1 AFP PIK3R1 RELA HEL-S-15 IKBKB CCL8 CCL7 CCL5 CCL4 CCL3 PTK2B MAPK1 CCL2 CCR5 MAPK3 CHUK SYK STAT1 STAT3 MAPK14 NFKBIA GRB2 PTPN6 CCL26 CCR7%IOB%CCR7 CCR7 PLCG1 CCL19 MAPK3 GSK3B CCL21 ADRB2 MAPK14 FOXO1 MTOR RELA HEL-S-15 MAPK8 RPS6KB1 PTK2B MAPK1 CCR7 FOXO3A CCR9%IOB%CCR9 CCR9 MAPK3 CCL25 GSK3B ITGA4 RDX MAPK14 FOXO1 MAPK8 RPS6KB1 MAPK1 CD226 ITGB7 MADCAM1 EZR HEL70 CD40%IOB%CD40 CD40 MAPK9 MAPK8 LCK MYC PLCG2 MAPK1 FYN JAK3 MAPK3 LYN JUN MAP2K1 CHUK SYK STAT3 PIK3R1 MAPK14 c-fgr IKBKB NFKBIA CXCR4%IOB%CXCR4 CXCR4 PLCG1 MAPK3 LYN STAT5B FYB1 VCAM1 BAD STAT1 STAT2 LIMK1 STAT3 PTPN11 NFKB1 NFKBIA PTPRC CXCL12 ARHA RPS6KB1 ACKR3 PTPN6 ATF1 GSK3B ITK ARRB2 CRKL IKBKB RPS6KA2 HEL-S-1 FOXO3A RAC1 CCR5 JAK3 NCK1 MAP2K3 MAP2K1 MAP2K2 CHUK HEL-S-72p RPS6 VAV1 VAV2 DOK1 NR3A2 ZAP70 CREB1 LCK TFF2 LCP2 CRK USP14 SDC4 SRC PXN WAS CXCR4 PIK3R2 PIK3R1 CBL EGFR GNAI1 RELA HEL-S-15 GNA13 INPP5D PLCG2 STAT4 PTK2B MAPK1 FYN EGFR1%IOB%EGFR1 EGFR1 SDC3 PIK3R3 PIK3R2 PIK3R1 PTTG1IP IQGAP1 PRKCZ MYL12B HEL-S-15 SLC5A5 MYO6 PLCG2 COX2 PLCG1 S100A14 STX4A SNX5 S100A10 LYN VASP STAT5B JUN JUND JUP HEL107 INSR PTK6 BRAF CDC2 SMU1 CYLD TRIP6 SDC1 GRB2 CALM1 CC2D1A ARF4 PYGB CLTC RPLP0 CLTA AP2A1 PTPRK WASL ARHGAP5 SHB LIMD1 PTPRF PS1TP5BP1 OTUD6B ENSA RAC1 PLEKHN1 HRAS APPL2 APPL1 JAK1 VAV3 SERPINB3 CDV3 ANXA1 ANXA2 ANXA4 PGAM1 MINK1 FOS EPS15L1 TYK2 VAV1 VAV2 PLSCR1 GPRC5A KIT ARHGEF4 ARHGEF7 ARHGEF5 CSTB HEL-S-87p PHLPP1 AHNAK HTT NEDD9 RPS27L PRKX SNX33 EGFR RELA PAK1 PDZD11 ADRBK1 AP2S1 FLNB CD59 RPS2 LDLR MPZL1 MAP3K2 GIT2 MAP3K1 CAVIN1 STAT1 CAVIN2 STAT2 STAT3 HUWE1 PLEKHA5 ERBIN PLEKHA6 HIPK2 ITCH KRT18 ARHA AXL NEDD4 PKN2 EPPK1 ESYT1 FRK SH3GL3 PRAG1 CTNND1 INPPL1 ARHGAP35 STK11 C11orf52 LAPTM4A CYSRT1 CDH2 GRB14 HNRPR GRB10 SIRPA SH3GL2 KRT6A MAP2K3 MAGI1 RALBP1 KIRREL1 MAP2K1 MAP2K2 DYRK1A PRP4K DYRK1B TOM1L1 EEF1A1 TOM1L2 DOK1 ADAM17 HGS EEF1A2 HAT1 PKP2 ELMO2 ADAM9 PKP4 PKP3 RAF1 STAM2 PHLDB2 COL17A1 KHDRBS1 SHC1 HEL-S-132P PXN DAPP1 LPP FOXO1 PLD2 EFNB2 SDCBP SOCS3 ATXN2 SOCS1 UBB HNRNPDL CALD1 CASKIN2 EIF4EBP1 ABL2 RIPK1 MAP2K5 SMAD2 HEL-S-94n CAV2 TNK2 CRIM1 HEL-S-133P NFKB1 PTPRE ARHGAP32 CDK5 SP1 CDK2 ALB BCL2 RAB5A MAP3K14 EIF4G1 ITGB1 HEL-S-112 GSK3B DYRK4 GSK3A DYRK3 DOCK4 DDX3X USP31 CALCOCO2 ITGB4 HEL-S-30 HEL-S-115 HEL-S-36 PTEN PIK3CD HEL-S-34 PIK3C2B RBM3 CASP9 FLOT1 NCK2 FLOT2 HEL-S-1 CCDC50 NCK1 ACTR3 TGIF1 ACTR2 PDCD6IP PDPK1 LSR ARAP1 YWHAZ EPN1 EPN2 EPN3 ACTA2 SFPQ CREB1 ELF3 PIK3CA LCK PEAK1 MYH9 DSG2 SOS1 CRK DOCK1 MET SOS2 SLC25A6 PLEC CEBPA CEBPB PRKAA1 PRKAA2 RALB WBP2 HDAC1 SRC RGS16 MVP ITLN2 ASAP1 ATP1A1 SRI CBL CDC42 MAPK9 MAPK8 MAPK7 MARVELD2 ERBB3 ERBB2 SLITRK6 REPS2 PTK2B MAPK1 CSK FYN RBBP7 MTA2 PDLIM4 SH2B1 MAPK3 SNCA PTPN18 PTPN1 PPP1R14B HEL-S-43 EGF BAD SPRY4 PTPN11 PPP2R3A BAIAP2 MAPK14 MTOR H3-4 RPS6KB1 SPRY2 SPRY1 PTPN6 TIEG2 DNCL1 SPG20 NECTIN1 ZPR1 ATF1 ITSN2 USP6NL APP ERRFI1 RPL30 AHCYL1 TFRC ZDHHC5 ARAF HEL113 CBLC HEL114 ENO1 ANTXR1 CRKL RPS6KA3 GJA1 BAIAP2L1 RPS6KA5 TFG SNRPD2 UBASH3B TRIM29 MYC RPS6KA2 RPS6KA1 EPHB2 ANKS1A TNS4 SLC12A7 EPHB1 RPS10 TNS3 EPHB4 TNS2 EPHB3 TNS1 EPHA4 PRKCI PRKCB ACTN1 KRT7 FRS2 SCRIB PRKCA KRT5 ACTN4 SCAMP3 KIAA1217 GAREM1 ZFYVE16 PRKAR1A PARD3 RBCK1 PRKD1 EPHA1 PFN1 TLN1 RIN1 EPHA2 GRB7 SDC4 CTBP1 EPO%IOB%EPO EPO GSK3A FOXO4 FOXO1 CRKL RPS6KA5 H2BC21 MAPK1 FOXO3A SH2B2 MAPK3 STAT5B JUN MAP2K1 MAP2K2 SYK BAD STAT3 PTPN11 BRAF EPOR MTOR VAV1 HCLS1 RAF1 SGK1 FAS%IOB%FAS Fas RIPK2 ANXA4 UBE4B TRAF2 CSNK1E TRAF1 LCK TRAF3 CSNK2B TCP1 BTK MET PLEC GTF3C3 PARG ROCK1 UBA7 MAX PRKDC DIABLO SATB1 USO1 GLRX STK4 DEDD2 CDC42 MAPK1 FYN RIPK1 CD59 FADD EIF4B DEDD MAPK3 LYN MBD4 CASP8AP2 TIA1 CSNK1A1 EIF2AK2 BMX EIF2S1 HEL-S-283 WEE1 TNFSF6 STK24 NEDD4 EIF3J BCL2 FAS BAX PKN2 PTPN6 PKN1 BCL2L1 GSK3B NUMA1 FAF1 HEL113 PARK2 TIAL1 CASP9 CASP8 AIFM1 CASP6 CASP10 FASTK CASP3 ARHGDIB XPO5 CASP4 CDC27 CASP2 RAC1 MAP3K5 CAST HEL-S-102 DFFA MAP2K1 MAP2K2 PARP1 CSNK2A1 RFC1 FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 LYN ATF1 CEBPA ATF2 JUN CREB1 FLT3 STAT3 MAPK1 GAB2 CBL MAPK3 G-CSF%IOB%G-CSF G-CSF MAPK14 LCK CDK2 IL3RA REL GRB2 CSF3 POM121 CDKN1B CSF3R PLA2G1B SHC1 CBL SOCS3 FTH1 INPP5D RPS6KA1 MAPK1 JAK1 MAPK3 LYN STAT5B PRKCI CISH SYK STAT1 STAT3 PTPN11 CSNK1E HEL-S-44 SYP TYK2 GAB2 GDNF%IOB%GDNF GDNF FYN RAF1 CRK MET RET JUN MAP2K1 MAP2K2 PXN CDC2 NFKBIA DOK1 RPS6KA3 RPS6KB1 TH PTK2B GM-CSF%IOB%GM-CSF GM-CSF GSK3B GSK3A CSF2 CRKL IKBKB RPS6KA2 SPTAN1 MAP2K3 MAP2K1 MAP2K2 CHUK SYK HEL-S-269 HEL-S-69 PRKCA VAV1 TGFBR3 CREB1 HNRNPH1 PFN1 RAF1 EZR STAM2 SHC1 PXN CSF2RB PIK3R2 PIK3R1 CBL HEL-S-67p CSF2RA PRDX3 MAPK9 GANAB MAPK8 MAPK1 PLCG1 SH2B2 MAPK3 MAP2K6 LYN STAT5B TGFB1 YES1 BAD STAT1 STAT3 MAPK14 NFKBIA PTPRC RPS6KB1 FES GRB2 PTPN6 HEDGEHOG%IOB%HEDGEHOG Hedgehog HEL2 DHH HHIP IHH ARRB2 GLI3 MED12 SHH CCNB1 ADRBK1 SUFU BOC SAP18 MED1 PTCH1 PTCH2 DYRK1A KIF7 MED6 KIF27 MED23 CDK8 SMO CTNNB1 GAS1 ID%IOB%ID ID ID3 HES1 TCF3 ATF3 MYF5 RB1 TCF7L2 PAX5 ELK3 RBL2 RBL1 PSMD4 ID2 MYOD1 CDK2 ID1 ID4 IFN-ALPHA%IOB%IFN-ALPHA IFN-alpha IRS1 CBL FOXO1 CRKL RPS6KA5 ERBB3 EIF4EBP1 STAT4 EIF4B JAK1 MAP2K6 IFNAR2 MAP2K3 MAP2K4 STAT5B STAT1 STAT2 RPS6 STAT3 TYK2 MTOR VAV1 NFKBIA ZAP70 ARHGAP30 RPS6KB1 PRKCQ CRK IFNAR1 IFN-GAMMA%IOB%IFN-GAMMA IFN-gamma MAPK14 CBL EGFR CRKL HOXA10 MAPK11 MAPK8 IRF1 IRF2 PLCG2 IRF8 MAPK1 PRKCQ RAF1 CRK JAK1 MAPK3 CEBPB SPI1 IFNGR1 STAT1 STAT3 KITRECEPTOR%IOB%KITRECEPTOR KitReceptor IL7R MAD2L1 PTPRU ATF2 GSK3B WIPF1 CLTC CRKL GYS1 SPRED1 RPS6KA1 EP300 HRAS JAK3 PRKCB RPS6 MATK PRKCA DOK1 PIK3CA KIT RAF1 SOS1 CRK GRB7 SHC1 SRC WAS CSF2RB PIK3R2 PIK3R1 CBL RELA MAPK8 SOCS1 INPP5D EIF4EBP1 MAPK1 FYN PLCG1 SOCS6 SOCS4 SOCS5 LYN STAT5B JUN YES1 STAT1 PTPN11 TNFRSF10A MAPK14 EPOR c-fgr MTOR KITLG TEC RPS6KB1 FES GRB2 GRAP LEPTIN%IOB%LEPTIN Leptin RPS6 STAT3 PIK3R2 PTPN11 PIK3R1 SLC2A4 MAPK14 EGFR RPS6KB1 SP1 LEP LEPR PDE3A MAPK1 GRB2 ITGAV SOCS7 JAK3 MAPK3 KHDRBS1 ITGB5 IRS1 PRKCE M-CSF%IOB%M-CSF M-CSF STAT3 INPPL1 HEL113 GAB3 PTPN11 PIK3R1 CBL ETS2 CASP8 PSTPIP2 INPP5D GRAP2 PTK2B GRB2 RIPK1 MAJN FADD CSF1R STAT5B CSF1 SHC1 NGF%IOB%NGF NGF PRKCI MAP2K1 CREB1 SP1 MAPK1 FRS2 MAPK3 NOTCH%IOB%NOTCH Notch GSK3B APP MAML2 MAML1 FHL1 RBPJ LFNG YY1 POFUT1 SIN3A MAGEA1 EP300 CCN3 SKP2 SKP1 PSENEN HES6 FBXW7 SAP30 RBX1 NCOR2 KAT2B NCOR1 MFNG NUMB MAML3 NOTCH2 NOTCH3 HDAC2 NOTCH1 HDAC1 LEF1 PSEN2 DTX1 FURIN PSEN1 RELA DLL3 DLL4 APH1B MAPK1 CIRSR HES1 HIVEP3 MAPK3 SPEN JAG2 SMAD1 SMAD4 STAT3 NFKB1 ITCH SNW1 TCF3 TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_beta_Receptor FOS TGFBR1 PJA1 TGFBR2 RBL2 TGFBR3 KAT2B ZEB2 RBL1 TFDP1 EIF3S2 TFDP2 STRAP CRK CD44 ENG YAP1 ROCK1 HDAC1 LEF1 FZR1 MAPK8 PARD6A STAMBPL1 MAPK1 E2F4 E2F5 MAPK3 NFYA NR1i1 NFYB NFYC MAPK14 PML FKBP1A SKI MAP3K7IP1 ARHA CTNNB1 FOSB RB1 ATF2 SPARC ZFYVE9 UBE2D2 UBE2D3 UBE2D1 PPP2R2A NR2A1 HOXA9 STK11 CDC23 FNTA CCND1 MYC CDC27 EP300 SNIP1 FOXO3A SOX9 BTRC JUNB MAP3K7 VPS39 SKP1 MAP2K3 NUP214 MEF2C ANAPC7 PRKCB FOXH1 RUNX2 RBX1 EID2 ZFYVE16 PRKAR1B EWSR1 CCNE1 HGS ANAPC5 ATF3 ANAPC1 ANAPC2 SDC2 PXN PIK3R2 FOXO4 PIK3R1 ANAPC10 FOXO1 SNX4 CCNB2 SNX1 SNX2 SKIL SPTBN1 MAP2K6 SNX6 SMAD2 WWTR1 CREBBP JUN SMAD4 JUND TGFB1 SMURF2 STK11IP SMURF1 IRF2BP1 NUP153 SMAD6 CDC2 CDK6 COPS5 SNW1 CDK4 SP1 CDK2 DYNLRB2 DCP1A TP73 CDKN1A CITED1 CTCF ARRB2 BRCA1 XPO4 SUMO1 MAP4K1 TGIF1 NCOA1 HEL-S-72p THROMBOPOIETIN%IOB%THROMBOPOIETIN Thrombopoietin MPL MAPK1 FOXO3A MAPK3 ATXN2L STAT5B MAP2K1 SHC1 STAT3 TIE1 TEK%IOB%TIE1 TEK TIE1 TEK NCK1 MAPK3 GRB7 STAT5B MAP2K1 MAP2K2 SHC1 MAPK14 BMX PAK1 FES MAPK1 RAF1 TNFALPHA%IOB%TNFALPHA TNFalpha BAG4 BRINP1 G3BP2 RIPK1 FADD MAP2K5 MAP2K6 CREBBP JUN UBE2I CRADD SEC16A MCC NFKB1 NFKB2 SMARCA4 CDK9 NFKBIA COPS5 REL ALPL TAB3 NFKBIE MAP3K14 MAP3K11 NFKBIB DDX3X HSP90AB1 MCM7 FAF1 TRADD TNFAIP3 IKBKAP IKBKB PPP6C CASP8 YWHAQ BCL7A SUMO1 PPP1R13L NKIRAS1 CASP10 NKIRAS2 CASP3 NFKBIZ CASP2 HEL-S-1 IKBKG IKBKE YWHAG HEL-S-102 RIPK3 CHUK PEG3 SYK ACTL6A TRAF2 COMMD1 TRAF1 TNFRSF1B YWHAZ TNFRSF1A CREB1 RASA3 TRAF4 MUXA POLR1A TRAF3 TRAF6 TRAF5 POLR1C POLR1D MCM5 PFDN2 BIRC2 HDAC2 HDAC1 SRC USP11 AKAP8 MTIF2 NR2C2 TANK HDAC6 EGFR RELA RELB MAPK9 MAPK8 TIFA FLNA MAPK1 POLR2H POLR2L MAPK3 MAP3K2 SMARCE1 MAP3K1 RNF25 STAT1 PTPN11 MAPK14 LRPPRC PML KTN1 MAP3K7IP1 RPS6KB1 GLB1 TNIP2 PRC1 PSMC1 PDCD2 TBKBP1 PKN1 RB1 RPL4 RPL30 HEL2 UBE2D2 UBE2D3 ZFAND5 RPL8 TNF DCAF7 RPL6 FBL PSMD6 TBK1 PSMD7 RPS6KA5 PSMD2 PSMD3 PAPOLA KPNA6 DPF2 PSMD1 TNFRSF8 MAP3K8 KPNA2 RPS11 AZI2 BTRC KPNA3 MAP3K7 RPS13 GTF2I SKP1 SMARCC1 SMARCC2 CSNK2A1 FBXW11 FBXW7 USP2 DOK1 TXLNA CDC34 FANCD2 CDC37 MAPKAPK2 TRIB3 NUPR1 FKBP5 NSMAF COPB2 PSMD12 PSMD13 TNFRSF11A PRKCZ GLG1 TNFSF1%IOB%TNFSF1 TNFSF1 JUN TNFRSF1B NFKB1 RELA NFKB2 RELB TNFRSF1A NFKBIA TRAF3 TRAF5 LTA TNFRSF14 LTBR IKBKG TNFSF3%IOB%TNFSF3 TNFSF3 JUN TRAF2 TNFRSF1B NFKB1 RELA NFKB2 RELB TNFRSF1A NFKBIA TRAF3 TRAF5 LTA LTB LTBR TNFSF8%IOB%TNFSF8 TNFSF8 NFKB1 RELA NFKB2 RELB TRAF3 REL MAPK1 TNFRSF8 TRAF1 TRAIL%IOB%TRAIL TRAIL AIFM1 CASP10 CHEK2 CASP3 TNFSF10 MAPK1 CASP2 RIPK1 BAK1 IKBKG FADD MAP3K7 MCL1 MAPK3 PARP1 CSNK2A1 APAF1 TNFRSF10C TNFRSF10B TRAF2 TNFRSF10A MAPK14 NFKB1 TNFRSF10D NFKBIA CREB1 CTNNB1 CYCS BAX ATM DAP3 H2AX BEX3 PRKAA1 PRKDC DIABLO SRC TRADD TNFRSF11B BCL10 CBL RELA CASP8 WNT%IOB%WNT Wnt CSNK1A1 FZD4 WNT3A FZD7 FZD9 NFATC2 WNT7A FZD8 BCL9 CDK6 APC ARHA CTNNB1 PIN1 TCF4 GSK3B GSK3A DIXDC1 ARRB2 STM7 SOX1 CCND1 HEL-S-1 RSPO1 RAC1 MAP3K7 PRKCB AXIN1 KREMEN1 PRKCA DKK1 HEL-S-28 PAX2 SFRP1 DAAM1 ARHGEF4 ROR1 ROR2 PI4K2A CTBP1 LEF1 LRP5 NLK MESD LRP6 PPP2CA MAPK8 FRZB DVL1 DVL2 GPC3 DVL3 WNT1 WNT3 WNT4 FZD1 SMAD1 TCF7L2 GCKR JUN FZD3 YES1 JUP FZD5 SETDB1 BIOCARTA_TERT_PATHWAY%MSIGDB_C2%BIOCARTA_TERT_PATHWAY BIOCARTA_TERT_PATHWAY SP3 MZF1 HDAC1 SP1 MAX WT1 MYC PID_IL2_PI3K_PATHWAY%MSIGDB_C2%PID_IL2_PI3K_PATHWAY PID_IL2_PI3K_PATHWAY MYC SGMS1 SHC1 PIK3R1 IL2RG PRKCZ RELA UGCG TERT SMPD1 MYB FOXO3A RAC1 JAK3 JAK1 RPS6 PTPN11 GAB2 IL2 NFKB1 MTOR RPS6KB1 PIK3CA LCK IL2RA IL2RB BCL2 GRB2 SOS1 EIF3A BCL2L1 PID_E2F_PATHWAY%MSIGDB_C2%PID_E2F_PATHWAY PID_E2F_PATHWAY HEL126 SIRT1 HIC1 CCNA2 RBL2 KAT2B KAT2A RBL1 TFDP1 CCNE2 TFDP2 CCNE1 MCM3 CES8 CES3 CES2 CES1 CEBPA TYMS RBBP4 RBBP8 E2F2 E2F3 E2F4 WASF1 E2F5 E2F7 MCL1 RANBP1 CREBBP RRM1 RRM2 CDKN2C HEL25 CDKN2A CDC6 CDC2 DHFR POLA1 RYBP CDK2 ATM TP73 HDAC1 SP1 MYC RB1 CDKN1A CDKN1B ORC1L TRRAP BRCA1 UXT YY1 CCND3 TRIM28 EP300 MYBL2 TK1 TOPBP1 SULT2A1 APAF1 PID_P53_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_P53_DOWNSTREAM_PATHWAY PID_P53_DOWNSTREAM_PATHWAY EGFR PERP TP53INP1 SPP1 DROSHA PMS2 BAK1 TIGAR NR1i1 NFYA GDF15 NFYB NFYC ARID3A POU4F1 POU4F2 PML APC RFWD2 CARM1 CCNG1 FAS BAX CEBPZ SP1 BCL2 BCL2L1 RB1 CDKN1A TRRAP EP300 APAF1 HIC1 KAT2A TFDP1 E2F2 E2F3 MCL1 CREBBP TP73 FOXA1 STEAP3 CCNK HEL-S-130P CD82 PRDM1 PYCARD SESN1 FDXR TP63 BNIP3L S100A2 HGF TAP1 TSC2 PRKAB1 DKK1 MSH2 DDIT4 ATF3 EPHA2 DDX5 TGFA CCNB1 PCBP4 TP53BP2 PMAIP1 SFN SCN3B BCL2L14 PLK3 JUN GADD45A SH2D1A TNFRSF10C LIF TNFRSF10B TNFRSF10A TNFRSF10D SMARCA4 TADA2B RGCC TP53I3 BCL6 JMY MDM2 SNAI2 BCL2L2 COL18A1 BTG2 PPP1R13B HEL-S-31 PTEN TRIAP1 CX3CL1 BBC3 PIDD1 CASP10 CASP6 AIFM2 BDKRB2 DGCR8 ZNF385A DUSP5 GPX1 EDN2 PRMT1 MMP2 SERPINB5 DDB2 RNF144B VCAN RRM2B MET HDAC2 PCNA BCL2A1 TYRP1 TAF9 HTT RPS27L PPM1J NLRC4 AFP RCHY1 PID_FANCONI_PATHWAY%MSIGDB_C2%PID_FANCONI_PATHWAY PID_FANCONI_PATHWAY H2AX BLM WDR48 FAAP24 BRCA2 BRIP1 CHEK1 USP1 HES1 NBN ATRIP RFC3 RFC4 FANCM FANCL FBXW11 RFC2 RMI1 ATM TOP3A XRCC3 RPA1 FANCA MRE11A HUS1 FANCC FANCB FANCE PALB2 FANCG BRCA1 FANCF RAD50 FANCD2 UBE2T RAD17 RAD1 FAN1 ATR TOPBP1 CENPS RAD9A BIOCARTA_MEF2D_PATHWAY%MSIGDB_C2%BIOCARTA_MEF2D_PATHWAY BIOCARTA_MEF2D_PATHWAY NFATC2 PRKCA NFATC1 CABIN1 PPP3CA PPP3CC CAPNS1 CAPNS2 CALM1 MEF2D HDAC1 HDAC2 EP300 PRKCB BIOCARTA_PPARG_PATHWAY%MSIGDB_C2%BIOCARTA_PPARG_PATHWAY BIOCARTA_PPARG_PATHWAY NCOA1 EP300 MED1 RXRA CREBBP LPL PPARG PPARGC1A PID_TGFBR_PATHWAY%MSIGDB_C2%PID_TGFBR_PATHWAY PID_TGFBR_PATHWAY PPP1R15A PML YAP1 HEL2 SHC1 ZFYVE9 CAMK2A PPP2R2A ARRB2 CTGF PPP2CA PARD6A DACT2 MAP3K7 SKIL RNF111 SPTBN1 EIF2A SMAD2 SMAD4 TGFB1 SMURF2 PDPK1 SMURF1 AXIN1 RPS6KB1 WWP1 TGFBR1 TGFBR2 FKBP1A TGFBR3 MAP3K7IP1 GRB2 ITCH SOS1 ZFYVE16 ARHA BAMBI STRAP CTNNB1 PID_SYNDECAN_4_PATHWAY%MSIGDB_C2%PID_SYNDECAN_4_PATHWAY PID_SYNDECAN_4_PATHWAY ACTN1 FZD7 PRKCA FGF7B F2 NUDT16L1 MMP9 CXCL12 TACI ADAM12 FGFR1 RAC1 ARHA ITGB1 SDC4 LAMA1 LAMA3 TNC CXCR4 PLG TFPI THBS1 FGF2 SDCBP MDK CCL5 PID_LPA4_PATHWAY%MSIGDB_C2%PID_LPA4_PATHWAY PID_LPA4_PATHWAY ADCY1 LPAR4 ADCY8 ADCY6 CREB1 ADCY9 GNAL RPS6KA5 PRKCE ADCY3 PID_NECTIN_PATHWAY%MSIGDB_C2%PID_NECTIN_PATHWAY PID_NECTIN_PATHWAY RAPGEF1 ITGAV PIP5K1C TLN1 CRK NECTIN3 NECTIN2 PIK3CA NECTIN1 CTNNB1 FARP2 PIK3R1 SRC ITGB3 PTPRM IQGAP1 F11R CLDN1 VAV2 CDC42 AFDN RAC1 RAP1A CTNNA1 PID_AURORA_B_PATHWAY%MSIGDB_C2%PID_AURORA_B_PATHWAY PID_AURORA_B_PATHWAY TACC1 KIF20A tmp_locus_29 HEL25 HEL113 CDCA8 NCAPG HEL-S-34 KLHL13 CENPA AURKC SMC4 ARHA AURKB MYLK SMC2 AURKA PPP1CC SGOL1 NPM1 SEPTIN1 KNTC2 NSUN2 KIF23 PPP2R5D KLHL9 INCENP NCL BIRC5 PID_ARF6_TRAFFICKING_PATHWAY%MSIGDB_C2%PID_ARF6_TRAFFICKING_PATHWAY PID_ARF6_TRAFFICKING_PATHWAY KNS2 RALA CLTC CTNND1 SLC2A4 ASAP2 ADRB2 PLD2 INS EDNRB ITGA4 EXOC7 ITGA2 AVPR2 ITGA1 MAPK8IP3 TSHR ACAP1 BIN1 AGTR1 EXOC4 ITGA7 EXOC3 ITGA6 EXOC6 EXOC5 EXOC2 VAMP3 CTNNA1 EXOC1 ARF6 ITGAV PIP5K1C IL2RA CTNNB1 ITGB1 BIOCARTA_TGFB_PATHWAY%MSIGDB_C2%BIOCARTA_TGFB_PATHWAY BIOCARTA_TGFB_PATHWAY SMAD2 SMAD4 MAP2K1 TGFB1 MAPK3 TGFBR1 TGFBR2 MAP3K7IP1 APC ZFYVE9 EP300 MAP3K7 SKIL CREBBP PID_A6B1_A6B4_INTEGRIN_PATHWAY%MSIGDB_C2%PID_A6B1_A6B4_INTEGRIN_PATHWAY PID_A6B1_A6B4_INTEGRIN_PATHWAY EGFR PRKCA SFN RXRA HEL2 SHC1 PIK3R1 ITGA6 RAC1 COL17A1 LAMA5 ITGB4 LAMA4 RPS6KB1 LAMC2 PIK3CA MST1R LAMC1 RXRB ERBB3 YWHAQ GRB2 ERBB2 HEL-S-1 HRAS RXRG YWHAG LAMB3 ITGB1 EGF LAMB2 MET LAMA1 LAMB1 LAMA3 YWHAZ IL1A PMP22 CD9 BIOCARTA_MRP_PATHWAY%MSIGDB_C2%BIOCARTA_MRP_PATHWAY BIOCARTA_MRP_PATHWAY ABCC3 ABCC1 ABCB1 ABCB4 HEL-S-22 ABCB11 PID_EPHB_FWD_PATHWAY%MSIGDB_C2%PID_EPHB_FWD_PATHWAY PID_EPHB_FWD_PATHWAY GRB7 ROCK1 PXN ITSN1 WASL EFNA5 KALRN EFNB2 EFNB1 PAK1 NRAS EFNB3 RRAS MAPK1 EPHB2 EPHB1 EPHB4 EPHB3 NCK1 SHC1 TF PIK3R1 SYNJ1 SRC KRAS CDC42 RAC1 HEL-S-31 RAP1A MAP2K1 MAPK3 CRK PIK3CA GRB2 HRAS PID_MYC_PATHWAY%MSIGDB_C2%PID_MYC_PATHWAY PID_MYC_PATHWAY PIN1 SKP2 CDKN2A AXIN1 KAT2A MAX MYC PML TRRAP GSK3B TAF12 FBXW7 PPP2CA TAF10 TAF9 ACTL6A PPP2R5A SUPT7L KAT5 RUVBL2 RUVBL1 BIOCARTA_PLCE_PATHWAY%MSIGDB_C2%BIOCARTA_PLCE_PATHWAY BIOCARTA_PLCE_PATHWAY ADCY1 RAP2B PRKAR1B PRKAR1A PTGER1 PRKACG PLCE1 ADRB2 PID_HIF1_TFPATHWAY%MSIGDB_C2%PID_HIF1_TFPATHWAY PID_HIF1_TFPATHWAY CXCL12 CREB1 TF MCL1 CREBBP TFRC EPO CITED2 HEL-S-30 BHLHE41 ADM RORA ENO1 HK2 NR2A1 CA9 IGFBP1 EDN1 FOS HEL-S-68p NPM1 ADFP TFF3 ABCG2 ENG HEL-S-87p BHLHB2 FURIN GATA2 HIF1A HDAC7 NT5E HMOX1 EGLN1 EGLN3 NOS2 BNIP3 HEL-S-133P CP GCK NCOA1 JUN VEGFA PFKL COPS5 SP1 LEP ID2 TERT SMAD4 CXCR4 EP300 ABCB1 PID_NFKAPPAB_ATYPICAL_PATHWAY%MSIGDB_C2%PID_NFKAPPAB_ATYPICAL_PATHWAY PID_NFKAPPAB_ATYPICAL_PATHWAY NFKB1 PIK3CA LCK CSNK2A1 SYK CSNK2A2 MAPK14 IKBKB PIK3R1 NFKBIA SRC CSNK2B ARRB2 REL RELA BIOCARTA_EPHA4_PATHWAY%MSIGDB_C2%BIOCARTA_EPHA4_PATHWAY BIOCARTA_EPHA4_PATHWAY ITGB1 LYN SELP ACTA1 EPHA4 FYN EPHB1 PID_ERBB_NETWORK_PATHWAY%MSIGDB_C2%PID_ERBB_NETWORK_PATHWAY PID_ERBB_NETWORK_PATHWAY EGFR BTC TGFA NRG3 NRG4 ERBB4 HBEGF ERBB3 ERBB2 EGF NRG1 NRG2 AREG EREG PID_ENDOTHELIN_PATHWAY%MSIGDB_C2%PID_ENDOTHELIN_PATHWAY PID_ENDOTHELIN_PATHWAY PRKCA JUN ADCY9 EDNRB GNAL MAPK1 PRKCE ADCY3 ADCY1 ADCY8 MAPK14 ADCY6 SRC CDC42 RAC1 MAP2K1 MAPK3 CRK GNAZ GNAI3 GNAI1 GNA14 EDNRA MAPK8 GNA15 GNA11 EDN2 KPG_011 PTK2B HRAS TRPC6 ARHA MAP2K2 PRKCH EDN3 GNAO1 EDN1 SLC9A3 FOS PLCB3 COL3A1 COL1A2 PRKCQ RAF1 PLCB1 PLCB2 PRKCB BIOCARTA_FREE_PATHWAY%MSIGDB_C2%BIOCARTA_FREE_PATHWAY BIOCARTA_FREE_PATHWAY XDH TNF NFKB1 RELA GPX1 HEL-75 HEL-S-64p CXCL8 HEL-S-44 BIOCARTA_CYTOKINE_PATHWAY%MSIGDB_C2%BIOCARTA_CYTOKINE_PATHWAY BIOCARTA_CYTOKINE_PATHWAY TNF IL10 IFNA1 IL2 IFNB1 IL15 IL13 IL18 IL16 IL4 IL3 IL6 IL5 TXLNA IFNG IL9 IL17A IL1A CXCL8 BIOCARTA_STRESS_PATHWAY%MSIGDB_C2%BIOCARTA_STRESS_PATHWAY BIOCARTA_STRESS_PATHWAY MAP2K6 TNF NFKB1 JUN MAPK8 MAP2K3 ATF1 MAPK14 MAP4K2 IKBKB MAP2K4 NFKBIA MAP3K1 CHUK CRADD RELA TRADD TRAF2 TANK TNFRSF1A CASP2 RIPK1 IKBKG MAP3K14 PID_HIF1A_PATHWAY%MSIGDB_C2%PID_HIF1A_PATHWAY PID_HIF1A_PATHWAY EGLN2 CDKN2A HIF3A EGLN1 RBX1 EGLN3 OS9 ARD1A VHL ELOC HIF1AN COPS5 HIF1A PID_ANGIOPOIETIN_RECEPTOR_PATHWAY%MSIGDB_C2%PID_ANGIOPOIETIN_RECEPTOR_PATHWAY PID_ANGIOPOIETIN_RECEPTOR_PATHWAY GRB7 TNF PXN F2 PAK1 PLD2 MAPK1 NCK1 MAPK14 SHC1 PIK3R1 AGTR1 RELA FYN RAC1 PTPN11 MAPK3 NFKB1 CRK RPS6KB1 PIK3CA FOXO1 MAPK8 GRB14 ANGPT4 STAT5B GRB2 ANGPT2 ANGPT1 MMP2 BMX ELF1 CDKN1A ELF2 FES ITGB1 PLG FGF2 BIOCARTA_G2_PATHWAY%MSIGDB_C2%BIOCARTA_G2_PATHWAY BIOCARTA_G2_PATHWAY CCNB1 CDC2 ATM GADD45A YWHAQ CDKN1A CDKN2D PRKDC PLK1 BRCA1 MYT1 CDC25B WEE1 MDM2 CDC34 CHEK2 EP300 RPS6KA1 ATR CHEK1 BIOCARTA_IL3_PATHWAY%MSIGDB_C2%BIOCARTA_IL3_PATHWAY BIOCARTA_IL3_PATHWAY MAP2K1 MAPK3 IL3 STAT5B GRB2 SOS1 HRAS SHC1 FOS RAF1 CSF2RB IL3RA PTPN6 PID_RAS_PATHWAY%MSIGDB_C2%PID_RAS_PATHWAY PID_RAS_PATHWAY RASGRF1 DAB2IP PRKCA RASAL1 RASGRP4 RASGRP3 SYNGAP1 RASA4 RASA2 PLCE1 NF1 RIN1 NRAS SOS2 RRAS GRB2 SOS1 PRKCE HRAS KRAS PRKCZ PRKCB RASGRF2 BIOCARTA_IL2_PATHWAY%MSIGDB_C2%BIOCARTA_IL2_PATHWAY BIOCARTA_IL2_PATHWAY MAP2K1 MAPK3 IL2 LCK IL2RA JUN MAPK8 IL2RB STAT5B GRB2 SOS1 CSNK2A1 HRAS SYK SHC1 FOS IL2RG RAF1 JAK3 JAK1 PID_ERBB2_ERBB3_PATHWAY%MSIGDB_C2%PID_ERBB2_ERBB3_PATHWAY PID_ERBB2_ERBB3_PATHWAY NRAS JUN CHRNA1 DOCK7 PIK3CD MAPK1 PIK3R3 PIK3R2 MAPK9 CHRNE BAD SHC1 STAT3 PIK3R1 NFATC4 SRC RNF41 KRAS MAPK10 NF2 CDC42 NRG1 RAC1 NRG2 MAP2K1 PTPN11 MAPK3 MTOR PIK3CA MAPK8 ERBB3 GRB2 ERBB2 SOS1 HRAS MAP2K2 FOS RAF1 BIOCARTA_AKAP95_PATHWAY%MSIGDB_C2%BIOCARTA_AKAP95_PATHWAY BIOCARTA_AKAP95_PATHWAY DDX5 CCNB1 CDC2 PRKACG PPP2CA PRKAG1 AKAP8 PID_IL2_STAT5_PATHWAY%MSIGDB_C2%PID_IL2_STAT5_PATHWAY PID_IL2_STAT5_PATHWAY CCNA2 IL4 SP1 MYC SHC1 PIK3R1 IL2RG PRF1 CCND2 FOXP3 CDK6 JAK3 TNFSF6 JAK1 LTA PTPN11 GAB2 IL2 PIK3CA LCK IL2RA IL2RB BCL2 STAT5B GRB2 SOS1 BCL2L1 ELF1 CCND3 PID_PDGFRA_PATHWAY%MSIGDB_C2%PID_PDGFRA_PATHWAY PID_PDGFRA_PATHWAY PDGFRA RAPGEF1 CAV3 ITGAV SHB CRKL SHF CRK PLCG1 PIK3CA JUN GRB2 SOS1 IFNG CSNK2A1 SHC1 PIK3R1 FOS JAK1 PID_REELIN_PATHWAY%MSIGDB_C2%PID_REELIN_PATHWAY PID_REELIN_PATHWAY RAPGEF1 CRKL LRPAP1 VLDLR PIK3CA CBL LRP8 GRIN2B MAPK8 DAB1 RELN CDK5 MAP1B NCK2 ARHGEF2 MAP3K11 CDK5R1 ITGB1 PAFAH1B1 PIK3R1 GSK3B FYN RAP1A BIOCARTA_P38MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_P38MAPK_PATHWAY BIOCARTA_P38MAPK_PATHWAY CREB1 MAX RPS6KA5 MYC MAPK14 SHC1 MAP2K4 MAP3K1 TRADD TRAF2 MAP3K7 CDC42 RIPK1 RAC1 MAP2K6 TGFB1 TGFBR1 GRB2 HRAS ATF2 HSPB2-C11orf52 MAP3K5 HMGN1 HEL-S-102 STAT1 DDIT3 MAPKAPK2 RAPGEF2 MAPKAPK5 BIOCARTA_RB_PATHWAY%MSIGDB_C2%BIOCARTA_RB_PATHWAY BIOCARTA_RB_PATHWAY RB1 CDC2 MYT1 CDC25B WEE1 CDK2 ATM CDK4 CHEK1 BIOCARTA_MET_PATHWAY%MSIGDB_C2%BIOCARTA_MET_PATHWAY BIOCARTA_MET_PATHWAY DOCK1 PAK1 JUN MAPK1 STAT3 PIK3R1 ACTA1 RAP1A PTEN RAPGEF1 MAP2K1 PTPN11 MAPK3 CRKL CRK PIK3CA MAPK8 GRB2 SOS1 PTK2B HRAS MAP2K2 ITGB1 MET FOS HGF RAF1 MAP4K1 BIOCARTA_ACE2_PATHWAY%MSIGDB_C2%BIOCARTA_ACE2_PATHWAY BIOCARTA_ACE2_PATHWAY ACE2 COL4A2 CMA1 COL4A1 COL4A4 COL4A3 AGTR1 COL4A6 COL4A5 REN AGTR2 BIOCARTA_STATHMIN_PATHWAY%MSIGDB_C2%BIOCARTA_STATHMIN_PATHWAY BIOCARTA_STATHMIN_PATHWAY CCNB1 PRKAR1B CDC2 PRKAR1A PRKACG TSG101 CD3G CD3E CD3D HEL-S-89n UHMK1 MAPK13 CD2 RB1CC1 CAMK4 PID_P38_ALPHA_BETA_PATHWAY%MSIGDB_C2%PID_P38_ALPHA_BETA_PATHWAY PID_P38_ALPHA_BETA_PATHWAY MAP2K6 RALA LCK PAK1 MAP3K7IP1 MAP2K3 MAPK14 MAP2K4 BLK SRC YES1 LYN RALB DUSP8 DUSP16 c-fgr MAPK11 FYN CDC42 DUSP10 TRAF6 RIPK1 RAC1 MAP3K12 BIOCARTA_41BB_PATHWAY%MSIGDB_C2%BIOCARTA_41BB_PATHWAY BIOCARTA_41BB_PATHWAY TNFRSF9 IL2 NFKB1 IL4 JUN MAPK8 IFNG MAPK14 IKBKB ATF2 NFKBIA MAP3K1 CHUK MAP3K5 RELA TRAF2 TNLG5A BIOCARTA_SALMONELLA_PATHWAY%MSIGDB_C2%BIOCARTA_SALMONELLA_PATHWAY BIOCARTA_SALMONELLA_PATHWAY WASL WASF1 ACTA1 CDC42 RAC1 PID_HNF3B_PATHWAY%MSIGDB_C2%PID_HNF3B_PATHWAY PID_HNF3B_PATHWAY F2 NF1 GCK CREB1 INS SP1 CEBPA ACADVL CEBPB ALAS1 CEBPD SLC2A2 NR3C1 HEL111 TFRC UCP2 NKX2-1 ACADM FOXA1 PCK1 CPT1A HMGCS1 PKLR ABCC8 FOXF1 NR2A1 PDX1 HNF1A IGFBP1 CPT1C G6PC1 BDH1 ALB ALDOB TCF2 FOXA3 FOXA2 AFP PID_IL4_2PATHWAY%MSIGDB_C2%PID_IL4_2PATHWAY PID_IL4_2PATHWAY IL10 IL4 IL5 ITGB3 CEBPB STAT5B FES TFF3 PIGR SPI1 IRS1 AID PTPN6 IL13RA2 MYBL1 IL13RA1 ARG1 GTF3A OPRM1 FCER2 IRF4 RETNLB CCL11 ALOX15 THY1 SOCS3 SOCS1 SP1 CCL17 SOCS5 EGR2 HMGA1 PARP14 MAPK14 COL1A1 SHC1 CD40LG PIK3R1 CCL26 IL2RG BCL6 SELP MYB JAK3 JAK1 LTA MTOR RPS6KB1 PIK3CA CBL GRB2 BCL2L1 COL1A2 PID_NCADHERIN_PATHWAY%MSIGDB_C2%PID_NCADHERIN_PATHWAY PID_NCADHERIN_PATHWAY ROCK1 CTNND1 FGFR1 PIK3R1 GRIA2 DAGLA DCTN1 LRP5 GJA1 CDH2 CNR1 CDC42 CAMK2G RAC1 HEL-S-61 PTPN1 CTNNA1 JUP GAP43 PTPN11 FER PIP5K1C MYL2 DAGLB MAPRE1 PLCG1 AXIN1 PIK3CA MAPK8 ARHA CTNNB1 BIOCARTA_HIF_PATHWAY%MSIGDB_C2%BIOCARTA_HIF_PATHWAY BIOCARTA_HIF_PATHWAY EDN1 ASPH VHL HEL-S-133P EPO JUN CREB1 EP300 VEGFA COPS5 HIF1A PID_LYMPH_ANGIOGENESIS_PATHWAY%MSIGDB_C2%PID_LYMPH_ANGIOGENESIS_PATHWAY PID_LYMPH_ANGIOGENESIS_PATHWAY MAPK3 CRK FLT4 VEGFC PIK3CA VEGFD CREB1 GRB2 ITGA4 MAPK1 SOS1 ITGA2 ITGA1 MAPK14 COL1A1 ITGB1 SHC1 MAP2K4 PIK3R1 COL1A2 MAPK11 RPS6KA1 BIOCARTA_P35ALZHEIMERS_PATHWAY%MSIGDB_C2%BIOCARTA_P35ALZHEIMERS_PATHWAY BIOCARTA_P35ALZHEIMERS_PATHWAY CDK5R1 GSK3B CAPNS1 CAPNS2 PPP2CA APP CDK5 PID_WNT_SIGNALING_PATHWAY%MSIGDB_C2%PID_WNT_SIGNALING_PATHWAY PID_WNT_SIGNALING_PATHWAY FZD7 FZD1 FZD2 FZD5 FZD4 IGFBP4 RYK WNT3A WNT7B ATP6AP2 FZD9 KREMEN1 FZD8 WNT7A FZD10 LRP5 LRP6 WIF1 RSPO1 DKK1 ROR2 WNT1 WNT3 CTHRC1 BIOCARTA_BARRESTIN_SRC_PATHWAY%MSIGDB_C2%BIOCARTA_BARRESTIN_SRC_PATHWAY BIOCARTA_BARRESTIN_SRC_PATHWAY KCNA2 MAP2K1 KCNA3 ADRBK1 MAPK3 GNAS MAPK1 HRAS MAP2K2 ADCY1 RAF1 c-fgr PLCB1 KCNA1 PID_ALPHA_SYNUCLEIN_PATHWAY%MSIGDB_C2%PID_ALPHA_SYNUCLEIN_PATHWAY PID_ALPHA_SYNUCLEIN_PATHWAY HEL-S-67p PARK2 SLC6A3 KLK6 UBE2L3 GRK5 PLD2 SNCA TH STUB1 MAPK1 HEL-117 CSNK2A1 SYK BAD BLK SRC YES1 LYN c-fgr FYN MAPK3 LCK FKBP1A PTK2B PPP2R5D PLCB2 BIOCARTA_PDGF_PATHWAY%MSIGDB_C2%BIOCARTA_PDGF_PATHWAY BIOCARTA_PDGF_PATHWAY PDGFRA MAP2K1 PRKCA MAPK3 PLCG1 PIK3CA JUN MAPK8 GRB2 SOS1 PDGFA CSNK2A1 HRAS SHC1 STAT3 MAP2K4 PIK3R1 MAP3K1 FOS STAT1 RAF1 PRKCB JAK1 BIOCARTA_VDR_PATHWAY%MSIGDB_C2%BIOCARTA_VDR_PATHWAY BIOCARTA_VDR_PATHWAY KAT2B NR1i1 NCOA1 MED1 HDAC1 RXRA PRMT1 SMARCE1 SMARCD1 SUPT16H SMARCC1 SMARCA4 SMARCC2 CARM1 BAZ1B ARID1A NCOR1 CHAF1A TSC2 ACTL6A EP300 CREBBP BIOCARTA_GRANULOCYTES_PATHWAY%MSIGDB_C2%BIOCARTA_GRANULOCYTES_PATHWAY BIOCARTA_GRANULOCYTES_PATHWAY TNF IL1A SELP CSF3 ITGAM SELPLG SELL PECAM1 ICAM2 CXCL8 IFNG PID_AMB2_NEUTROPHILS_PATHWAY%MSIGDB_C2%PID_AMB2_NEUTROPHILS_PATHWAY PID_AMB2_NEUTROPHILS_PATHWAY ROCK1 TNF MMP9 THY1 IL6 BLK SRC PRKCZ YES1 CTGF LYN SELP ITGAM SELPLG c-fgr FYN PLAT RAP1A HMGB1 AGER APOB JAM2 JAM3 TLN1 PLAUR NFKB1 MYH2 LPA MST1R LCK MMP2 ARHA PLG BIOCARTA_BAD_PATHWAY%MSIGDB_C2%BIOCARTA_BAD_PATHWAY BIOCARTA_BAD_PATHWAY MAPK3 PRKAR1B PRKAR1A PRKACG IGF1 PIK3CA IGF1R KITLG IL3 KIT BCL2 MAPK1 ADCY1 BAD PIK3R1 BAX RPS6KA1 CSF2RB IL3RA BIOCARTA_LYMPHOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_LYMPHOCYTE_PATHWAY BIOCARTA_LYMPHOCYTE_PATHWAY ITGB1 SELL SELE PECAM1 CD44 ITGA4 PID_FOXM1_PATHWAY%MSIGDB_C2%PID_FOXM1_PATHWAY PID_FOXM1_PATHWAY TGFA CCNB1 CCNA2 CCNE1 SP1 MYC BRCA2 CREBBP SKP2 MAP2K1 CDKN2A CDC2 LAMA4 CDK2 GSK3A CENPA ONECUT1 MMP2 FOXM1 RB1 AURKB CENPB CKS1B CCNB2 CCND1 NEK2 PLK1 NFATC3 FOS H2BC1 ETV5 CDC25B CENPF GAS1 CHEK2 EP300 CDK4 BIRC5 BIOCARTA_ARF_PATHWAY%MSIGDB_C2%BIOCARTA_ARF_PATHWAY BIOCARTA_ARF_PATHWAY RB1 CDKN2A PIK3R1 PIK3CA MDM2 POLR1A POLR1C POLR1D TWIST1 RAC1 TBX2 MYC PID_TXA2PATHWAY%MSIGDB_C2%PID_TXA2PATHWAY PID_TXA2PATHWAY EGFR PIK3R5 ROCK1 GNA13 PRKCA GNG2 ADRBK1 TBXA2R PTGDR PTGIR NHERF1 VCAM1 RAB11A GNB1 ARHGEF1 GNB5 PRKCE SYK MAPK14 BLK SRC ARRB2 PRKCZ YES1 LYN c-fgr FYN MAPK11 RAC1 GNA14 LCK GNA15 SELE GNA11 ARHA PRKCH EGF PRKCQ PLCB2 ARR3 PRKCB PID_ERBB4_PATHWAY%MSIGDB_C2%PID_ERBB4_PATHWAY PID_ERBB4_PATHWAY PRL PIK3CD LRIG1 MAPK1 PIK3R3 WWOX PIK3R2 CBFA2T3 PRLR YAP1 ADAM17 DLG4 SHC1 NEDD4 PIK3R1 NCOR1 MDM2 FYN NRG1 NRG2 EREG BTC NRG3 MAPK3 NRG4 ERBB4 HBEGF WWP1 PIK3CA GRIN2B STAT5B GRB2 ERBB2 ITCH BIOCARTA_CREB_PATHWAY%MSIGDB_C2%BIOCARTA_CREB_PATHWAY BIOCARTA_CREB_PATHWAY PRKCA MAPK3 PRKAR1B PRKAR1A PRKACG PIK3CA CREB1 GRB2 RPS6KA5 MAPK1 SOS1 HRAS ADCY1 MAPK14 PIK3R1 RPS6KA1 RAC1 PRKCB PID_IL8_CXCR2_PATHWAY%MSIGDB_C2%PID_IL8_CXCR2_PATHWAY PID_IL8_CXCR2_PATHWAY PRKCA GNG2 RAB11A GNB1 PLD2 IL8RB PPP2R1A ARRB2 VASP LYN ELMO1 PPP2CA DOCK2 RAB5A c-fgr RAB7A PDPK1 CBL GNA14 GNA15 PLCB3 PLCB1 PLCB2 CXCL8 PRKCB BIOCARTA_LIS1_PATHWAY%MSIGDB_C2%BIOCARTA_LIS1_PATHWAY BIOCARTA_LIS1_PATHWAY DCX DNCL1 NDEL1 LRP8 RELN CDK5 CSNK2A1 CDK5R1 PAFAH1B1 DCTN1 DCTN6 DNAH2 DNAH8 DCTN3 DNAH6 BIOCARTA_EPO_PATHWAY%MSIGDB_C2%BIOCARTA_EPO_PATHWAY BIOCARTA_EPO_PATHWAY MAP2K1 MAPK3 EPOR PLCG1 EPO JUN MAPK8 STAT5B GRB2 SOS1 CSNK2A1 HRAS SHC1 FOS RAF1 PTPN6 BIOCARTA_ERBB4_PATHWAY%MSIGDB_C2%BIOCARTA_ERBB4_PATHWAY BIOCARTA_ERBB4_PATHWAY ADAM17 NRG3 PRKCA ERBB4 PSEN1 NRG2 PRKCB BIOCARTA_UCALPAIN_PATHWAY%MSIGDB_C2%BIOCARTA_UCALPAIN_PATHWAY BIOCARTA_UCALPAIN_PATHWAY ACTN1 ITGB1 TLN1 ACTN2 CAPNS1 ITGB3 EZR CAPNS2 SPTAN1 ACTA1 RAC1 ARHA PID_NEPHRIN_NEPH1_PATHWAY%MSIGDB_C2%PID_NEPHRIN_NEPH1_PATHWAY PID_NEPHRIN_NEPH1_PATHWAY WASL JUN PIK3CD PIK3R3 PIK3R2 MAPK9 NCK1 BAD PIK3R1 MAP2K4 ARRB2 PRKCZ MAPK10 PARD6A FYN RAC1 PLCG1 PIK3CA PRKCI KIRREL1 MAPK8 CD2AP TJP1 NPHS1 GRB2 NPHS2 F2RL2 NCK2 TRPC6 BIOCARTA_THELPER_PATHWAY%MSIGDB_C2%BIOCARTA_THELPER_PATHWAY BIOCARTA_THELPER_PATHWAY CD2 THY1 CD3G CD3E CD3D PTPRC PID_CASPASE_PATHWAY%MSIGDB_C2%PID_CASPASE_PATHWAY PID_CASPASE_PATHWAY KRT18 TNF MADD GAS2 CYCS BIRC2 BIRC3 MAP3K1 BAX CRADD TRADD TRAF2 ACTA1 PRF1 TNFRSF1A CASP2 RIPK1 PIDD1 CASP10 CASP6 SPTAN1 HEL113 APP BCL2 NUMA1 SATB1 DIABLO LMNB2 CASP9 CASP8 CFL2 CASP3 ARHGDIB CASP4 LMNA TFAP2A DFFB DFFA PARP1 APAF1 LIMK1 PID_CDC42_PATHWAY%MSIGDB_C2%PID_CDC42_PATHWAY PID_CDC42_PATHWAY WASL ARPC1B ACTR3 ACTR2 PAX6 PAK1 TIAM1 ARHGEF7 IQGAP3 HEL-S-15 MAPK1 PRKCE HEL-S-47e HES5 PAK4 MAP2K3 SEPTIN2 APC LIMK2 TNK2 MAP2K4 BRAF SRC MAP3K1 ARPC4 GSK3B YES1 ARPC5 CDC42BPA IQGAP1 BAIAP2 ARPC2 ARPC3 VAV2 CDC42 CTNNA1 MAP2K6 RASGRF1 JUN EXOC7 MAPK9 MAPK14 PIK3R1 PRKCZ PARD6A RAC1 MYL2 MAPK3 MTOR RPS6KB1 PIK3CA CBL MAPK8 F2RL2 HRAS MAP3K11 CTNNB1 ATF2 RAF1 LIMK1 BIOCARTA_VEGF_PATHWAY%MSIGDB_C2%BIOCARTA_VEGF_PATHWAY BIOCARTA_VEGF_PATHWAY EIF2S2 PRKCA SUI1 EIF2S1 ELAVL1 EIF2S3 KDR PLCG1 FLT4 VHL EIF2B1 PIK3CA VEGFA HRAS SHC1 PIK3R1 EIF2B5 EIF2B3 EIF2B2 FLT1 EIF1AX PRKCB HIF1A BIOCARTA_AKT_PATHWAY%MSIGDB_C2%BIOCARTA_AKT_PATHWAY BIOCARTA_AKT_PATHWAY PDPK1 NFKB1 FOXO4 PIK3CA GHR FOXO1 GH1 BAD IKBKB PIK3R1 CASP9 NFKBIA CHUK RELA PPP2CA FOXO3A TNFSF6 IKBKG BIOCARTA_RAB_PATHWAY%MSIGDB_C2%BIOCARTA_RAB_PATHWAY BIOCARTA_RAB_PATHWAY RAB8A RAB11A ACTA1 RAB5A RAB2A RAB7A RAB1A RAB4A RAB6C RAB9A RAB27A BIOCARTA_CREM_PATHWAY%MSIGDB_C2%BIOCARTA_CREM_PATHWAY BIOCARTA_CREM_PATHWAY ADCY1 FSHB FSHR CREM FHL5 PID_SYNDECAN_3_PATHWAY%MSIGDB_C2%PID_SYNDECAN_3_PATHWAY PID_SYNDECAN_3_PATHWAY EGFR PSEN1 PSENEN SRC NCAN SDC3 CASK PTN MC4R POMC FYN APH1B AgRP CXCL8 PID_AURORA_A_PATHWAY%MSIGDB_C2%PID_AURORA_A_PATHWAY PID_AURORA_A_PATHWAY FZR1 TACC1 DLGAP5 TDRD7 CKAP5 TACC3 AURKAIP1 AJUBA RAN PAK1 GADD45A ARHGEF7 NFKBIA GSK3B MDM2 NDEL1 CENPA AURKB AURKA BRCA1 CDC25B PPP2R5D HCTP4 OAZ1 BIRC5 PID_MYC_ACTIV_PATHWAY%MSIGDB_C2%PID_MYC_ACTIV_PATHWAY PID_MYC_ACTIV_PATHWAY MMP9 KAT2A E2F3 BAX TAF12 TAF10 ACTL6A SUPT7L KAT5 CREBBP RUVBL2 RUVBL1 NBN EIF2S1 TFRC ENO1 NPM1 NCL BIRC5 CCNB1 PMAIP1 HEL-S-133P EIF4A1 BMI1 PEG10 UBTF PIM1 RCC1 MAX HEL-S-162eP ID2 MYC CAD NME2 HMGA1 PTMAP7 BCAT1 SHMT1 IREB2 RPL11 CDCA7 MTDH HSPD1 PRDX3 TERT MDIG CCND2 MYCT1 PDCD10 EIF4E HSPA4 HUWE1 KIR3DL1 SMAD4 FOSL1 LIN28B GPAM POLR3D NDUFAF2 SNAI1 TAF4B SERPINI1 PFKM EIF4G1 TRRAP TAF9 EP300 TK1 CDK4 BIOCARTA_HER2_PATHWAY%MSIGDB_C2%BIOCARTA_HER2_PATHWAY BIOCARTA_HER2_PATHWAY EGFR MAP2K1 MAPK3 ERBB4 PIK3CA GRIP1 IL6 ERBB3 GRB2 IL6ST ERBB2 MAPK1 SOS1 IL6R HRAS SHC1 STAT3 CARM1 PIK3R1 RAF1 EP300 BIOCARTA_PTC1_PATHWAY%MSIGDB_C2%BIOCARTA_PTC1_PATHWAY BIOCARTA_PTC1_PATHWAY CCNH PTCH1 CCNB1 MNAT1 CDC2 CDC25B CDK7 SHH BIOCARTA_BIOPEPTIDES_PATHWAY%MSIGDB_C2%BIOCARTA_BIOPEPTIDES_PATHWAY BIOCARTA_BIOPEPTIDES_PATHWAY MAP2K1 PRKCA MAPK3 F2 PLCG1 CALM1 MAPK8 AGTR2 GNA11 GRB2 CDK5 MAPK1 SOS1 PTK2B HRAS MAP2K2 MAPK14 SHC1 STAT3 KNG1 STAT1 RAF1 FYN PRKCB PID_P38_MK2_PATHWAY%MSIGDB_C2%PID_P38_MK2_PATHWAY PID_P38_MK2_PATHWAY SFN CREB1 TH YWHAQ HEL-S-1 YWHAG HEL2 MAPK14 MAPKAPK3 TCF3 YWHAZ CDC25B HEL-S-102 TSC2 RAF1 MAPK11 MAPKAPK2 PID_TNF_PATHWAY%MSIGDB_C2%PID_TNF_PATHWAY PID_TNF_PATHWAY CYLD TNF MADD TNIK SQSTM1 NSMAF BIRC2 BIRC3 MAP2K3 ADAM17 IKBKB MAP4K2 MAP3K1 PRKCZ CHUK RELA TRADD TRAF2 SMPD1 MAP3K7 TNFRSF1A RIPK1 HEL-S-31 IKBKG NFKB1 PRKCI MAP3K7IP1 CASP8 NRK MAP3K5 TNFAIP3 TXN SMPD2 STAT1 BAG4 FADD RFFL MAP4K3 TRAF1 TNFRSF1B BIOCARTA_NOS1_PATHWAY%MSIGDB_C2%BIOCARTA_NOS1_PATHWAY BIOCARTA_NOS1_PATHWAY PRKCA DLG4 PRKAR1B PPP3CA PRKAR1A GRIN1 PPP3CC PRKACG CALM1 GRIN2B PRKCB BIOCARTA_TCYTOTOXIC_PATHWAY%MSIGDB_C2%BIOCARTA_TCYTOTOXIC_PATHWAY BIOCARTA_TCYTOTOXIC_PATHWAY CD2 CD8A THY1 CD3G CD3E CD3D PTPRC PID_GLYPICAN_1PATHWAY%MSIGDB_C2%PID_GLYPICAN_1PATHWAY PID_GLYPICAN_1PATHWAY SMAD2 TGFB1 PRNP SERPINC1 PLA2G2A TGFBR1 LCK APP CRIPTO TGFBR2 FGFR1 VEGFA GPC1 SLIT2 BLK SRC LAMA1 YES1 LYN c-fgr FYN NRG1 FGF2 FLT1 BIOCARTA_NGF_PATHWAY%MSIGDB_C2%BIOCARTA_NGF_PATHWAY BIOCARTA_NGF_PATHWAY MAP2K1 MAPK3 PLCG1 PIK3CA JUN MAPK8 NGFR GRB2 NGF SOS1 DPM2 CSNK2A1 HRAS SHC1 PIK3R1 FOS RAF1 PID_CXCR3_PATHWAY%MSIGDB_C2%PID_CXCR3_PATHWAY PID_CXCR3_PATHWAY GNG2 CCL11 GNB1 NRAS PIK3CD MAPK1 PIK3R3 CXCL9 PIK3R2 MAPKAP1 CXCL13 MAP2K3 CXCR3 MAPK14 MLST8 PIK3R1 RICTOR SRC CXCL10 KRAS CXCL11 PF4 MAPK11 MAP2K6 MAP2K1 MAPK3 PDPK1 GNAZ MTOR GNAI3 GNAI1 PIK3CA HRAS MAP2K2 GNAO1 RAF1 BIOCARTA_TRKA_PATHWAY%MSIGDB_C2%BIOCARTA_TRKA_PATHWAY BIOCARTA_TRKA_PATHWAY PRKCA SHC1 PIK3R1 PLCG1 PIK3CA NTRK1 GRB2 SOS1 NGF DPM2 PRKCB HRAS BIOCARTA_PLK3_PATHWAY%MSIGDB_C2%BIOCARTA_PLK3_PATHWAY BIOCARTA_PLK3_PATHWAY PLK3 ATM CHEK2 ATR CHEK1 PID_VEGFR1_PATHWAY%MSIGDB_C2%PID_VEGFR1_PATHWAY PID_VEGFR1_PATHWAY PRKCA PTPN11 MAPK3 PDPK1 PLCG1 PIK3CA CBL VEGFA CD2AP MAPK1 NCK1 PIK3R1 NRP1 SHC2 NRP2 VEGFB FLT1 PRKCB HIF1A BIOCARTA_VIP_PATHWAY%MSIGDB_C2%BIOCARTA_VIP_PATHWAY BIOCARTA_VIP_PATHWAY NFATC2 NFATC1 PRKAR1B NFKB1 PPP3CA PRKAR1A PPP3CC PLCG1 PRKACG CALM1 EGR2 MYC NFKBIA MAP3K1 CHUK RELA VIPR2 VIP PID_GMCSF_PATHWAY%MSIGDB_C2%PID_GMCSF_PATHWAY PID_GMCSF_PATHWAY NRAS PIM1 MAPK1 SYK SHC1 IKBKB STAT3 PIK3R1 KRAS LYN CSF2 CSF2RA CCL2 MAP2K1 PTPN11 MAPK3 CISH GAB2 OSM IRF8 PRKACG PIK3CA STAT5B GRB2 SOS1 HRAS MAP2K2 FOS YWHAZ STAT1 RAF1 CSF2RB BIOCARTA_BARRESTIN_PATHWAY%MSIGDB_C2%BIOCARTA_BARRESTIN_PATHWAY BIOCARTA_BARRESTIN_PATHWAY KCNA2 ADCY1 KCNA3 ADRBK1 GNAS NR1C1 AP2A1 AP2M1 PLCB1 KCNA1 BIOCARTA_CARDIACEGF_PATHWAY%MSIGDB_C2%BIOCARTA_CARDIACEGF_PATHWAY BIOCARTA_CARDIACEGF_PATHWAY EGFR PRKCA NFKB1 PLCG1 ADAM12 EDNRA JUN AGTR2 EDNRB ARHA MYC HRAS EGF EDN1 FOS RELA PRKCB PID_WNT_NONCANONICAL_PATHWAY%MSIGDB_C2%PID_WNT_NONCANONICAL_PATHWAY PID_WNT_NONCANONICAL_PATHWAY NFATC2 ROCK1 FZD7 PPARG MAPK9 CAMK2A ARRB2 PRKCZ YES1 MAPK10 MAP3K7 CDC42 RAC1 NLK DVL1 MAPK8 DVL2 DVL3 FZD2 FLNA FZD5 MAP3K7IP1 SETDB1 CSNK1A1 ARHA DAAM1 ROR2 CTHRC1 BIOCARTA_IL12_PATHWAY%MSIGDB_C2%BIOCARTA_IL12_PATHWAY BIOCARTA_IL12_PATHWAY MAP2K6 IL18 JUN MAPK8 CD3G CD3E CD3D IFNG TYK2 STAT4 MAPK14 CXCR3 CCR5 IL12RB1 IL18R1 ETV5 BIOCARTA_P27_PATHWAY%MSIGDB_C2%BIOCARTA_P27_PATHWAY BIOCARTA_P27_PATHWAY RB1 SKP2 CKS1B CDKN1B RBX1 NEDD8 UBE2M SKP1 TFDP1 CDK2 CCNE1 BIOCARTA_RELA_PATHWAY%MSIGDB_C2%BIOCARTA_RELA_PATHWAY BIOCARTA_RELA_PATHWAY TNF NFKB1 IKBKB NFKBIA CHUK RELA TRADD EP300 TNFRSF1A FADD CREBBP TRAF6 RIPK1 IKBKG TNFRSF1B PID_ARF6_PATHWAY%MSIGDB_C2%PID_ARF6_PATHWAY PID_ARF6_PATHWAY EGFR GULP1 EFNA1 PXN ACAP2 ADRB2 NCK1 TSHR ACAP1 SRC ITGB3 ARRB2 AGTR1 ARF6 GNA14 GNA15 GNA11 EGF MET HGF ITGA2B CYTH2 KIF13B FBXO8 LHCGR USP6 ARAP2 IPCEF1 EPHA2 PID_RXR_VDR_PATHWAY%MSIGDB_C2%PID_RXR_VDR_PATHWAY PID_RXR_VDR_PATHWAY TNF TGFB1 ABCA1 THRA NR1H2 NR1C1 NR1H4 RPS6KB1 NR1H3 NR1i1 NR1C2 NR1B3 NCOA1 NR1A2 RXRB MED1 NCOR2 BCL2 RXRA FAM120B RARA RARB PPARG RXRG PID_NFKAPPAB_CANONICAL_PATHWAY%MSIGDB_C2%PID_NFKAPPAB_CANONICAL_PATHWAY PID_NFKAPPAB_CANONICAL_PATHWAY CYLD PRKCA TNF NFKB1 BIRC2 RAN ATM RIPK2 UBE2D3 BCL10 NOD2 IKBKB ERC1 NFKBIA CHUK TNFAIP3 RELA TNFRSF1A TRAF6 IKBKG PID_IL1_PATHWAY%MSIGDB_C2%PID_IL1_PATHWAY PID_IL1_PATHWAY SQSTM1 JUN IKBKB ERC1 HEL-S-71 PIK3R1 IL1RN PRKCZ IRAK1 CHUK RELA TICAM2 IL1R1 IL1R2 IRAK3 MAP3K7 IRAK4 IL1B TRAF6 UBE2V1 IKBKG MYD88 MAP2K6 NFKB1 PIK3CA PRKCI MAPK8 MAP3K7IP1 IL1A BIOCARTA_GCR_PATHWAY%MSIGDB_C2%BIOCARTA_GCR_PATHWAY BIOCARTA_GCR_PATHWAY NPPA CORIN GNAS PIK3R1 NFKB1 NR3C1 PIK3CA RELA CALM1 ADRB2 ANXA1 PID_RHOA_REG_PATHWAY%MSIGDB_C2%PID_RHOA_REG_PATHWAY PID_RHOA_REG_PATHWAY ARHGEF5 ARHGEF1 HEL-S-47e VAV2 TRIO ARHGAP8 ARHGEF25 ARHGEF28 ARHGDIG ARHGEF10L ARHGAP5 ARHGAP35 ARHGAP4 OPHN1 MCF2L ECT2 SRGAP1 ARHGEF11 ARHA VAV3 ARHGEF2 ARHGEF10 CDKN1B FARP1 ARHGEF12 ARHGEF15 ARHGEF17 PLEKHG6 ARHGEF18 ARHGDIB MYO9B ARAP1 DEF6 VAV1 NET1 BCR OBSCN ARHGEF3 BIOCARTA_CFTR_PATHWAY%MSIGDB_C2%BIOCARTA_CFTR_PATHWAY BIOCARTA_CFTR_PATHWAY ADCY1 CFTR PRKAR1B PRKAR1A NHERF1 PRKACG EZR ADRB2 BIOCARTA_SAM68_PATHWAY%MSIGDB_C2%BIOCARTA_SAM68_PATHWAY BIOCARTA_SAM68_PATHWAY KHDRBS1 MAPK3 CDC2 MAPK1 HRAS PID_LIS1_PATHWAY%MSIGDB_C2%PID_LIS1_PATHWAY PID_LIS1_PATHWAY PLA2G7 KATNA1 DYNC1H1 NUDC DYNLT1 HEL-S-303 CDK5R2 CSNK2A1 HEL2 IQGAP1 CDC42 RAC1 DCX NDEL1 LRPAP1 VLDLR LRP8 DAB1 RELN CDK5 MAP1B ARHA CDK5R1 PAFAH1B1 PPP2R5D BIOCARTA_RACCYCD_PATHWAY%MSIGDB_C2%BIOCARTA_RACCYCD_PATHWAY BIOCARTA_RACCYCD_PATHWAY MAPK3 NFKB1 PIK3CA TFDP1 CDK2 PAK1 CCNE1 MAPK1 ARHA HRAS RB1 CDKN1A CDKN1B IKBKB CCND1 PIK3R1 NFKBIA CHUK RELA RAF1 CDK6 RAC1 CDK4 IKBKG PID_AVB3_OPN_PATHWAY%MSIGDB_C2%PID_AVB3_OPN_PATHWAY PID_AVB3_OPN_PATHWAY SPP1 MMP9 ROCK2 JUN PIP5K1A HEL-S-28 MAPK1 SYK PIK3R1 NFKBIA MAP3K1 ITGB3 CHUK RELA CDC42 RAC1 MAP3K14 ITGAV MAPK3 NFKB1 PIK3CA MAPK8 CD44 PTK2B MMP2 ARHA VAV3 FOS PID_DELTA_NP63_PATHWAY%MSIGDB_C2%PID_DELTA_NP63_PATHWAY PID_DELTA_NP63_PATHWAY PERP SFN NR1i1 TOP2A NOTCH1 RRAD STXBP4 YAP1 DLX5 DLX6 TBXT HELLS GPX2 GSK3B TCF7L1 ADRM1 FBXW7 KRT5 MDM2 POU2F2 RUNX1 PPP2R5A FOSL2 BRCA2 NRG1 AXL FASN KRT14 RAB38 HES1 ADA CDKN2A CEBPD BDKRB2 WWP1 ATM ITCH MRE11A CCNB2 TP63 IL1A PID_ECADHERIN_KERATINOCYTE_PATHWAY%MSIGDB_C2%PID_ECADHERIN_KERATINOCYTE_PATHWAY PID_ECADHERIN_KERATINOCYTE_PATHWAY EGFR CASR FMN1 ZYX PLCG1 CTNND1 AJUBA PIK3CA PIP5K1A ARHA CTNNB1 PIK3R1 SRC VASP FYN RAC1 JUP CTNNA1 BIOCARTA_NKT_PATHWAY%MSIGDB_C2%BIOCARTA_NKT_PATHWAY BIOCARTA_NKT_PATHWAY TGFB1 IL2 CCR1 IFNGR1 IFNGR2 CCL4 CCL3 IL4 CCR7 CCR4 CCR3 IL5 IFNG CXCR3 CCR5 CD40LG IL12RB1 IL18R1 CXCR4 CSF2 PID_IFNG_PATHWAY%MSIGDB_C2%PID_IFNG_PATHWAY PID_IFNG_PATHWAY SOCS1 MAPK1 IFNG STAT3 CAMK2A PIK3R1 MAP3K1 CAMK2G IL1B CREBBP RAP1A JAK1 RAPGEF1 MAP2K1 PTPN11 CEBPB MAPK3 CRKL IFNGR1 MTOR PIK3CA CBL CAMK2D PIAS1 IRF1 IRF9 MAP3K11 STAT1 EP300 BIOCARTA_NPP1_PATHWAY%MSIGDB_C2%BIOCARTA_NPP1_PATHWAY BIOCARTA_NPP1_PATHWAY IBSP ALPL COL4A2 ENPP1 SPP1 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 PID_INTEGRIN2_PATHWAY%MSIGDB_C2%PID_INTEGRIN2_PATHWAY PID_INTEGRIN2_PATHWAY JAM3 PLAUR VCAM1 THY1 FGA KNG1 CD40LG SPON2 F10 HEL-S-62p ICAM3 GP1BA ITGAM ICAM4 F11R HEL-S-78p CYR61 PROC ICAM2 FCGR2A PLAT ITGAX TGFBI BIOCARTA_P53_PATHWAY%MSIGDB_C2%BIOCARTA_P53_PATHWAY BIOCARTA_P53_PATHWAY TIMP3 CDK2 ATM GADD45A CCNE1 BCL2 RB1 CDKN1A CCND1 PCNA BAX MDM2 CDK4 APAF1 BIOCARTA_IL4_PATHWAY%MSIGDB_C2%BIOCARTA_IL4_PATHWAY BIOCARTA_IL4_PATHWAY SHC1 IL2RG RPS6KB1 IL4 GRB2 IRS1 JAK3 JAK1 BIOCARTA_IRES_PATHWAY%MSIGDB_C2%BIOCARTA_IRES_PATHWAY BIOCARTA_IRES_PATHWAY EIF4A2 AAG1 EIF4A1 EIF4G1 EIF4E EIF3A BIOCARTA_DSP_PATHWAY%MSIGDB_C2%BIOCARTA_DSP_PATHWAY BIOCARTA_DSP_PATHWAY MAPK14 MAPK3 DUSP4 DUSP2 DUSP9 DUSP8 MAPK8 BIOCARTA_FEEDER_PATHWAY%MSIGDB_C2%BIOCARTA_FEEDER_PATHWAY BIOCARTA_FEEDER_PATHWAY TREH PYGM PYGL LCT HEL-S-49 KHK BIOCARTA_RANKL_PATHWAY%MSIGDB_C2%BIOCARTA_RANKL_PATHWAY BIOCARTA_RANKL_PATHWAY FOSL1 IFNB1 NFKB1 MAPK8 IFNAR2 EIF2AK2 TNFRSF11A TNFSF11 IRF9 IFNAR1 FOS RELA FOSL2 TRAF6 BIOCARTA_DC_PATHWAY%MSIGDB_C2%BIOCARTA_DC_PATHWAY BIOCARTA_DC_PATHWAY IL10 IFNA1 IFNB1 IL13 IL4 IL3 IL5 IFNG CD40 CD2 CD5 CD7 TLR7 CD33 ITGAX CSF2 PID_CONE_PATHWAY%MSIGDB_C2%PID_CONE_PATHWAY PID_CONE_PATHWAY GNAT2 RDH12 RGS9BP GRK7 CNGB3 GNB3 PDE6C RDH5 CNGA3 LRAT GNB5 SLC24A2 GUCY2D PDE6H GUCA1B GUCA1A GUCA1C GUCY2F RPE65 GRK1 ARR3 GNGT2 BIOCARTA_WNT_PATHWAY%MSIGDB_C2%BIOCARTA_WNT_PATHWAY BIOCARTA_WNT_PATHWAY SMAD4 AXIN1 NLK NR1C2 DVL1 FZD1 CTBP1 HDAC1 FRAT1 MAP3K7IP1 BTRC CSNK2A1 MYC APC HNF1A CTNNB1 CCND1 GSK3B PPP2CA WIF1 MAP3K7 WNT1 CREBBP PID_THROMBIN_PAR1_PATHWAY%MSIGDB_C2%PID_THROMBIN_PAR1_PATHWAY PID_THROMBIN_PAR1_PATHWAY ROCK1 GNA13 PRKCA GNG2 F2 GNB1 ROCK2 ARHGEF1 HEL-S-47e PIK3R1 VASP MYL2 ZYX GNAZ GNAI3 GNAI1 PIK3CA GNA14 GNA15 GNA11 SNX1 SNX2 F2RL2 TRPC6 F2R ARHA PKN1 GNAO1 PLCB3 PLCB1 PLCB2 PRKCB BIOCARTA_CHREBP_PATHWAY%MSIGDB_C2%BIOCARTA_CHREBP_PATHWAY BIOCARTA_CHREBP_PATHWAY PRKAR1B GNAS PRKAR1A PRKACG ADCY1 PRKAA1 PRKAB2 PRKAA2 PRKAG2 PRKAG3 MLXIPL PRKAG1 PPP2CA PRKAB1 BIOCARTA_ASBCELL_PATHWAY%MSIGDB_C2%BIOCARTA_ASBCELL_PATHWAY BIOCARTA_ASBCELL_PATHWAY IL10 IL2 IL4 CD40 CD40LG FAS HLA-DRB5 HLA-DRB4 CD80 HLA-DRA HLA-DRB3 HLA-DRB1 TNFSF6 PID_MET_PATHWAY%MSIGDB_C2%PID_MET_PATHWAY PID_MET_PATHWAY SH3GL2 HGS AKT1S1 PXN NUMB WASL ARHGEF4 RIN2 EIF4EBP1 EGR1 RANBP9 PAK1 RANBP10 MUC20 MAPK1 PAK4 APC NCK1 MLST8 MAP2K4 SRC MAP3K1 CDC42 RAP1A CTNNA1 RAPGEF1 CRK HGF JUN BAD SHC1 PIK3R1 PRKCZ PARD6A RAB5A RAC1 EIF4E PTPN1 ARF6 MAP2K1 PTPN11 GAB2 MAPK3 CRKL PDPK1 PLCG1 MTOR SNAI1 PIK3CA PRKCI CBL MAPK8 GRB2 SOS1 F2RL2 NCK2 HRAS ARHA MAP2K2 CTNNB1 MET RAF1 INPPL1 RPTOR DEPTOR BIOCARTA_NPC_PATHWAY%MSIGDB_C2%BIOCARTA_NPC_PATHWAY BIOCARTA_NPC_PATHWAY NUTF2 KPNA2 RAN NUP214 RANBP2 NUP210 RCC1 NUP62 NUP153 PID_PI3KCI_AKT_PATHWAY%MSIGDB_C2%PID_PI3KCI_AKT_PATHWAY PID_PI3KCI_AKT_PATHWAY SFN SLC2A4 MAPKAP1 HEL2 AKT3 BAD MLST8 KPNA1 RICTOR TBC1D4 SRC GSK3B CHUK FOXO3A PDPK1 MTOR FOXO4 FOXO1 YWHAQ GSK3A HEL-S-1 BCL2L1 CDKN1A YWHAG CDKN1B PRKDC CASP9 MAP3K5 YWHAZ RAF1 BIOCARTA_TSP1_PATHWAY%MSIGDB_C2%BIOCARTA_TSP1_PATHWAY BIOCARTA_TSP1_PATHWAY MAPK14 CD36 FOS CASP3 JUN FYN THBS1 BIOCARTA_EGF_PATHWAY%MSIGDB_C2%BIOCARTA_EGF_PATHWAY BIOCARTA_EGF_PATHWAY EGFR MAP2K1 PRKCA MAPK3 PLCG1 PIK3CA JUN MAPK8 GRB2 SOS1 CSNK2A1 HRAS EGF SHC1 STAT3 MAP2K4 PIK3R1 MAP3K1 FOS STAT1 RAF1 PRKCB JAK1 BIOCARTA_RNAPOL3_PATHWAY%MSIGDB_C2%BIOCARTA_RNAPOL3_PATHWAY BIOCARTA_RNAPOL3_PATHWAY GTF3C1 GTF3C3 SSB HEL-S-76p TBP GTF3C5 PID_AR_NONGENOMIC_PATHWAY%MSIGDB_C2%PID_AR_NONGENOMIC_PATHWAY PID_AR_NONGENOMIC_PATHWAY GNG2 GNB1 CREB1 MAPK1 PIK3R1 SRC CDC42 PLCG2 RAC1 PELP1 GNRH1 SHBG MAP2K1 MAPK3 GNAZ PLCG1 GNAI3 GNAI1 PIK3CA HRAS MAP2K2 GNAO1 FOS PLCB3 RAF1 PLCB1 PLCB2 PID_AR_TF_PATHWAY%MSIGDB_C2%PID_AR_TF_PATHWAY PID_AR_TF_PATHWAY HDAC7 SIRT1 KAT2B EGR1 NCOA1 JUN HDAC1 RXRA SMARCE1 CEBPA SMARCC1 MAPK14 CARM1 MAP2K4 SRC GSK3B REL MDM2 KAT5 CREBBP TMPRSS2 MAP2K6 KLK3 HOXB13 NR2C2 ZMIZ2 TRIM24 NR3C1 KAT7 SRY SPDEF FOXO1 POU2F1 RXRB MAPK8 NR0B1 SENP1 APPBP2 PDE9A RXRG PKN1 EP300 GATA2 RCHY1 PID_THROMBIN_PAR4_PATHWAY%MSIGDB_C2%PID_THROMBIN_PAR4_PATHWAY PID_THROMBIN_PAR4_PATHWAY ROCK1 GNA13 GNG2 MYL2 F2 GNA14 GNB1 ROCK2 GNA15 GNA11 F2RL2 F2RL3 ARHA PLCB2 BIOCARTA_MTA3_PATHWAY%MSIGDB_C2%BIOCARTA_MTA3_PATHWAY BIOCARTA_MTA3_PATHWAY SNAI1 HDAC1 HEL-S-130P HEL-S-162eP MBD3 GREB1 TUBA4A TUBA1A TUBA2 MTA3 HSPB2-C11orf52 HEL-S-102 SNAI2 HEL-S-87p BIOCARTA_MONOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_MONOCYTE_PATHWAY BIOCARTA_MONOCYTE_PATHWAY ITGB1 SELP ITGAM SELL SELE PECAM1 CD44 ITGA4 BIOCARTA_INTEGRIN_PATHWAY%MSIGDB_C2%BIOCARTA_INTEGRIN_PATHWAY BIOCARTA_INTEGRIN_PATHWAY ACTN1 ROCK1 CAPNS1 CAPNS2 JUN MAPK1 SHC1 ACTA1 FYN RAP1A RAPGEF1 MAP2K1 MAPK3 CRKL ZYX TLN1 ACTN2 MAPK8 GRB2 SOS1 HRAS ARHA MAP2K2 ITGB1 HEL114 CSK TNS1 PPP1R12B RAF1 BCR BIOCARTA_ARENRF2_PATHWAY%MSIGDB_C2%BIOCARTA_ARENRF2_PATHWAY BIOCARTA_ARENRF2_PATHWAY MAFK PRKCA NFE2L2 HMOX1 JUN MAPK8 CREB1 MAPK1 MAPK14 FOS HEL-S-166mP KEAP1 CRYZ POR FXYD2 MAFG PRKCB MAFF BIOCARTA_CSK_PATHWAY%MSIGDB_C2%BIOCARTA_CSK_PATHWAY BIOCARTA_CSK_PATHWAY ZAP70 PRKAR1B PRKAR1A PRKACG LCK CD3G CD3E CD3D PTPRC ADCY1 CSK HLA-DRB5 HLA-DRB4 HLA-DRA HLA-DRB3 HLA-DRB1 CREBBP BIOCARTA_PAR1_PATHWAY%MSIGDB_C2%BIOCARTA_PAR1_PATHWAY BIOCARTA_PAR1_PATHWAY ROCK1 PRKCA GNA13 F2 PIK3CA ARHGEF1 PTK2B F2RL3 F2R ARHA ADCY1 PIK3R1 PPP1R12B PLCB1 MAP3K7 PRKCB BIOCARTA_FXR_PATHWAY%MSIGDB_C2%BIOCARTA_FXR_PATHWAY BIOCARTA_FXR_PATHWAY ABCA1 FABP6 LDLR NR0B2 NR1H4 NR1H3 RXRA BIOCARTA_SUMO_PATHWAY%MSIGDB_C2%BIOCARTA_SUMO_PATHWAY BIOCARTA_SUMO_PATHWAY UBE2I SUMO1 SUMO3 SUMO2 UBA2 SAE1 PID_ATM_PATHWAY%MSIGDB_C2%PID_ATM_PATHWAY PID_ATM_PATHWAY MDC1 ABRAXAS1 RNF8 SMC3 UIMC1 TP53BP1 SMC1A RFWD2 TERF2 HEL-S-71 RBBP8 H2AX MDM2 BLM KAT5 NBN ATM CTBP1 TOP3A HEL-S-1 MRE11A BRCA1 RAD50 FANCD2 TRIM28 RAD17 CHEK2 RAD9A BIOCARTA_ETS_PATHWAY%MSIGDB_C2%BIOCARTA_ETS_PATHWAY BIOCARTA_ETS_PATHWAY RBL1 JUN NCOR2 HRAS HDAC5 CSF1R HDAC2 FOS CSF1 ETV3 E2F4 ETS2 SIN3B SIN3A BIOCARTA_DICER_PATHWAY%MSIGDB_C2%BIOCARTA_DICER_PATHWAY BIOCARTA_DICER_PATHWAY AGO4 AGO1 AGO2 DICER1 BIOCARTA_CTLA4_PATHWAY%MSIGDB_C2%BIOCARTA_CTLA4_PATHWAY BIOCARTA_CTLA4_PATHWAY CTLA4 PTPN11 ICOS ICOSLG IL2 PIK3CA LCK CD3G GRB2 CD3E CD3D PIK3R1 HLA-DRB5 HLA-DRB4 CD80 HLA-DRA HLA-DRB3 HLA-DRB1 ITK PID_INSULIN_GLUCOSE_PATHWAY%MSIGDB_C2%PID_INSULIN_GLUCOSE_PATHWAY PID_INSULIN_GLUCOSE_PATHWAY HEL-S-42 INSR ASIP LNPEP SFN PPP1R3A SLC2A4 PRKCI GYS1 TRIP10 STX4A INS VAMP2 YWHAQ HEL-S-1 STXBP4 YWHAG HEL2 PPP1CC TBC1D4 GSK3B PRKCZ YWHAZ BIOCARTA_RECK_PATHWAY%MSIGDB_C2%BIOCARTA_RECK_PATHWAY BIOCARTA_RECK_PATHWAY TIMP3 MMP9 MMP14 TIMP1 MMP2 RECK HRAS TIMP4 PID_SMAD2_3PATHWAY%MSIGDB_C2%PID_SMAD2_3PATHWAY PID_SMAD2_3PATHWAY SMAD2 CTDSP1 SMAD4 CTDSP2 KPNA2 CTDSPL MAPK3 MAP3K1 UBE2I NUP214 MAPK1 NUP153 BIOCARTA_ALK_PATHWAY%MSIGDB_C2%BIOCARTA_ALK_PATHWAY BIOCARTA_ALK_PATHWAY BMP4 BMP2 BMPR1A APC GSK3B MAP3K7 NPPA SMAD4 TGFB1 MYL2 AXIN1 TGFBR1 DVL1 TGFBR2 FZD1 TGFBR3 HNF1A CTNNB1 BMP10 ATF2 BMPR2 GATA4 NPPB DKFZp781O1323 NKX2-5 ACVR1 SMAD1 MEF2C WNT1 RFC1 NOG BMP7 BMP5 BIOCARTA_HDAC_PATHWAY%MSIGDB_C2%BIOCARTA_HDAC_PATHWAY BIOCARTA_HDAC_PATHWAY NFATC2 MAP2K6 NFATC1 CABIN1 MAPK7 INSR PPP3CA MYOD1 PPP3CC AVP CAMK1 IGF1 PIK3CA CAMK1G IGF1R CALM1 MAPK14 HDAC5 PIK3R1 BIOCARTA_PML_PATHWAY%MSIGDB_C2%BIOCARTA_PML_PATHWAY BIOCARTA_PML_PATHWAY SIRT1 TNF SUMO1 SP100 PAX3 PRAM1 RARA HRAS RB1 PML FAS TNFRSF1A CREBBP TNFSF6 TNFRSF1B PID_ALK2_PATHWAY%MSIGDB_C2%PID_ALK2_PATHWAY PID_ALK2_PATHWAY SMAD4 BMPR2 DKFZp781O1323 ACVR1 FKBP1A SMAD1 AMHR2 TLX2 SMAD9 AMH BMP7 BIOCARTA_EIF4_PATHWAY%MSIGDB_C2%BIOCARTA_EIF4_PATHWAY BIOCARTA_EIF4_PATHWAY EIF4A2 PRKCA AAG1 MAPK3 PDPK1 MTOR RPS6KB1 EIF4EBP1 PIK3CA EIF4A1 GHR EIF4G1 MAPK1 PABPC1 PDK2 MAPK14 PIK3R1 IRS1 EIF4E PRKCB PTEN PID_PI3KCI_PATHWAY%MSIGDB_C2%PID_PI3KCI_PATHWAY PID_PI3KCI_PATHWAY PIK3R5 ZAP70 NRAS PIK3CD PIK3R3 PIK3R2 SYK ARF1 DAPP1 BLNK PIK3R1 CYTH1 BLK SRC PLEKHA1 KRAS YES1 PLEKHA2 LYN BTK SGK1 LAT c-fgr ARF5 FYN PLCG2 FOXO3A RAC1 RAP1A ITK PTEN ARF6 PDPK1 PLCG1 PIK3CA LCK HRAS ARHA CYTH2 INPPL1 BIOCARTA_KREB_PATHWAY%MSIGDB_C2%BIOCARTA_KREB_PATHWAY BIOCARTA_KREB_PATHWAY ACO2 SDHA CS FH SUCLA2 HEL-S-32 OGDH PID_TAP63_PATHWAY%MSIGDB_C2%PID_TAP63_PATHWAY PID_TAP63_PATHWAY PERP PMAIP1 NR1i1 GDF15 GADD45A SP1 EGR2 PML IKBKB GPX2 TP53I3 FAS CHUK BAX MDM2 DICER1 ADA SMARCD3 BBC3 CDKN2A OGG1 CABL1 ITGB4 NOC2L EVPL CLCA2 WWP1 FLOT2 NQO1 TFAP2C DST YWHAQ AEN SSRP1 ITCH DHRS3 SHH SERPINB5 TRAF4 MFGE8 CDKN1A FDXR TP63 PLK1 S100A2 EP300 BIOCARTA_EFP_PATHWAY%MSIGDB_C2%BIOCARTA_EFP_PATHWAY BIOCARTA_EFP_PATHWAY CCNB1 SMURF2 CDC2 SMURF1 SFN CDK2 CDK5 CDK7 CDK8 CCNB2 CDK3 TRIM25 CDK6 CDK4 BIOCARTA_BOTULIN_PATHWAY%MSIGDB_C2%BIOCARTA_BOTULIN_PATHWAY BIOCARTA_BOTULIN_PATHWAY SNAP25 CHRM1 STX1A CHRNA1 VAMP2 PID_PLK1_PATHWAY%MSIGDB_C2%PID_PLK1_PATHWAY PID_PLK1_PATHWAY FZR1 CENPU C13orf34 KIF20A CCNB1 TUBG1 CENPE STAG2 PRC1 NUDC GORASP1 KIZ SPC24 PAK1 TPT1 ROCK2 PPP2R1A PPP2CA CDC2 FBXW11 RAB1A ECT2 ARHA AURKA SGOL1 PLK1 ERCC6L CDC25B BUB1B KNTC2 WEE1 CDC14B CDC20 GOLGA2 HEL-S-80p FBXO5 INCENP HCTP4 CLSPN NINL PID_RB_1PATHWAY%MSIGDB_C2%PID_RB_1PATHWAY PID_RB_1PATHWAY SIRT1 CCNA2 MYOD1 TFDP1 PAX3 CCNE1 CEBPA RBBP4 E2F2 E2F3 E2F4 TBP MAPK11 CREBBP CSF2 SKP2 CEBPB CDKN2A CEBPD CDK2 ELF1 CCND1 SPI1 SUV39H1 JUN AATF UBTF HDAC1 BRD2 SFTPD RUNX2 PPARG RBP2 ATF7 MAPK9 HDAC3 BGLAP MAPK14 SMARCA4 GSC CBX4 PPP2R3B TAF1 PPP2CA MDM2 CCND2 CDK6 CTBP1 RB1 CDKN1A CDKN1B ATF2 MET CCND3 RAF1 EP300 MEF2C CDK4 BIOCARTA_CDC25_PATHWAY%MSIGDB_C2%BIOCARTA_CDC25_PATHWAY BIOCARTA_CDC25_PATHWAY CDC2 MYT1 CDC25B WEE1 ATM CHEK1 PID_PI3K_PLC_TRK_PATHWAY%MSIGDB_C2%PID_PI3K_PLC_TRK_PATHWAY PID_PI3K_PLC_TRK_PATHWAY SFN EGR1 NRAS CREB1 NGF HEL2 BAD SHC1 CAMK2A PIK3R1 CAMK4 SRC KRAS GSK3B AGAP2 NTRK1 TRPC3 TRPV1 FOXO3A PDPK1 PLCG1 PIK3CA YWHAQ GRB2 SOS1 HEL-S-1 HRAS YWHAG CCND1 YWHAZ BIOCARTA_CDC42RAC_PATHWAY%MSIGDB_C2%BIOCARTA_CDC42RAC_PATHWAY BIOCARTA_CDC42RAC_PATHWAY PDGFRA PIK3R1 WASL PIK3CA PAK1 CDC42 RAC1 ARHA BIOCARTA_PGC1A_PATHWAY%MSIGDB_C2%BIOCARTA_PGC1A_PATHWAY BIOCARTA_PGC1A_PATHWAY HDAC5 PPP3CA CAMK4 PPP3CC NR1C1 CAMK1 SLC2A4 CAMK1G CALM1 ESRRA PPARGC1A PID_IGF1_PATHWAY%MSIGDB_C2%PID_IGF1_PATHWAY PID_IGF1_PATHWAY PTPN11 PXN CRKL PDPK1 CRK RPS6KB1 PIK3CA IGF1R GRB2 SOS1 NCK2 HRAS HEL2 BAD SHC1 PIK3R1 PRKCZ YWHAZ RAF1 GRB10 PRKD1 IRS1 PTPN1 BIOCARTA_CTL_PATHWAY%MSIGDB_C2%BIOCARTA_CTL_PATHWAY BIOCARTA_CTL_PATHWAY FAS PRF1 CD3G HLA-A CD3E TNFSF6 B2M CD3D BIOCARTA_ERK_PATHWAY%MSIGDB_C2%BIOCARTA_ERK_PATHWAY BIOCARTA_ERK_PATHWAY PDGFRA EGFR MAP2K1 MAPK3 GNAS IGF1R NGFR GRB2 NGF RPS6KA5 MAPK1 SOS1 DPM2 MYC HRAS MAP2K2 ITGB1 SHC1 STAT3 PPP2CA RAF1 RPS6KA1 BIOCARTA_ETC_PATHWAY%MSIGDB_C2%BIOCARTA_ETC_PATHWAY BIOCARTA_ETC_PATHWAY GPD2 UQCRC1 SDHA SDHC SDHD SLC25A4 HEL-S-123m SDHB SLC25A6 ZNF183 BIOCARTA_SARS_PATHWAY%MSIGDB_C2%BIOCARTA_SARS_PATHWAY BIOCARTA_SARS_PATHWAY MAPK14 FBL GPT EIF4E NCL PID_RETINOIC_ACID_PATHWAY%MSIGDB_C2%PID_RETINOIC_ACID_PATHWAY PID_RETINOIC_ACID_PATHWAY PRKCA MAPK3 CDC2 KAT2B NR1i1 NR1B3 NCOA1 RXRB MAPK8 RBP1 HDAC1 NCOR2 RXRA RARA MAPK1 CDK7 RARB CCNH RXRG HDAC3 MAPK14 MNAT1 EP300 CREBBP BIOCARTA_CALCINEURIN_PATHWAY%MSIGDB_C2%BIOCARTA_CALCINEURIN_PATHWAY BIOCARTA_CALCINEURIN_PATHWAY NFATC2 PRKCA NFATC1 PPP3CA PPP3CC PLCG1 CALM1 MARCKS SP1 SP3 CDKN1A NFATC4 NFATC3 PRKCB BIOCARTA_EICOSANOID_PATHWAY%MSIGDB_C2%BIOCARTA_EICOSANOID_PATHWAY BIOCARTA_EICOSANOID_PATHWAY TBXA2R PTGIR PTGER1 PTGER4 CYP2J2 KPG_011 PTGFR PTGIS EPHX2 PTGER2 EPHX1 PTGER3 PTGS2 PTGS1 ALOX5 ALOX5AP PTGES PLCB1 PID_AJDISS_2PATHWAY%MSIGDB_C2%PID_AJDISS_2PATHWAY PID_AJDISS_2PATHWAY EGFR IGF2 GNA13 ADAM10 HGS ZBTB33 MEP1B GDNF RIN2 CTNND1 TIAM1 SRC IQGAP1 RAB5A CDH2 RAB7A FYN CDC42 RAC1 CREBBP PTPN1 CTNNA1 JUP ARF6 CABL1 IGF1R SNX1 HRAS CTNNB1 EGF MET CASP3 RET ROBO1 SLIT1 NTRK2 MMP7 BDNF PTPN6 MMP3 BIOCARTA_NOTCH_PATHWAY%MSIGDB_C2%BIOCARTA_NOTCH_PATHWAY BIOCARTA_NOTCH_PATHWAY ADAM17 PSEN1 RBPJ FURIN NOTCH1 PID_ECADHERIN_STABILIZATION_PATHWAY%MSIGDB_C2%PID_ECADHERIN_STABILIZATION_PATHWAY PID_ECADHERIN_STABILIZATION_PATHWAY EGFR ACTN1 ROCK1 EFNA1 CYFIP2 CTNND1 NCKAP1 AQP5 AQP3 LPP LIMA1 MYO6 MGAT3 PLEKHA7 CAMSAP3 KIFC3 NCK1 VASP EXOC4 EXOC3 AFDN CTNNA1 ARF6 PIP5K1C MYL2 ZYX NECTIN2 IGF1R STX4A ARHA CTNNB1 EGF MET HEL114 HGF EPHA2 BIOCARTA_RANBP2_PATHWAY%MSIGDB_C2%BIOCARTA_RANBP2_PATHWAY BIOCARTA_RANBP2_PATHWAY HDAC9 PIAS2 HDAC6 SUMO1 RAN MDM2 HDAC1 RANBP2 PIAS1 BIOCARTA_TH1TH2_PATHWAY%MSIGDB_C2%BIOCARTA_TH1TH2_PATHWAY BIOCARTA_TH1TH2_PATHWAY IL2 IFNGR1 IFNGR2 IL18 IL4 IL2RA IFNG CD40 CD40LG IL12RB1 NR1i2 IL18R1 IL12B IL12A HLA-DRB5 HLA-DRB4 HLA-DRA HLA-DRB3 HLA-DRB1 BIOCARTA_TALL1_PATHWAY%MSIGDB_C2%BIOCARTA_TALL1_PATHWAY BIOCARTA_TALL1_PATHWAY NFKB1 MAPK8 MAPK14 CHUK TWEAK RELA TNFSF13 TRAF2 TNFRSF13C TRAF3 TNFRSF17 TNLG7A TRAF6 TNFSF12-TNFSF13 MAP3K14 BIOCARTA_CASPASE_PATHWAY%MSIGDB_C2%BIOCARTA_CASPASE_PATHWAY BIOCARTA_CASPASE_PATHWAY CASP10 BIRC2 CASP6 BIRC3 LMNB2 CASP9 CASP8 CASP3 ARHGDIB CASP4 PRF1 LMNA DFFB CASP2 DFFA PARP1 APAF1 BIOCARTA_IL1R_PATHWAY%MSIGDB_C2%BIOCARTA_IL1R_PATHWAY BIOCARTA_IL1R_PATHWAY TNF IFNA1 IFNB1 JUN IL6 MAP2K3 MAPK14 IKBKB NFKBIA IL1RN MAP3K1 IRAK1 CHUK RELA IL1R1 IRAK3 MAP3K7 IL1B TRAF6 IRAK2 MYD88 MAP3K14 MAP2K6 TGFB1 NFKB1 MAPK8 MAP3K7IP1 IL1A BIOCARTA_EDG1_PATHWAY%MSIGDB_C2%BIOCARTA_EDG1_PATHWAY BIOCARTA_EDG1_PATHWAY PDGFRA SPHK1 PRKCA S1PR1 ITGAV MAPK3 PIK3CA MAPK1 PDGFA ARHA ADCY1 PIK3R1 ITGB3 SMPD2 SMPD1 PLCB1 RAC1 SPHKAP PRKCB BIOCARTA_MHC_PATHWAY%MSIGDB_C2%BIOCARTA_MHC_PATHWAY BIOCARTA_MHC_PATHWAY PSMB6 CD74 TAP2 HLA-DRB5 HLA-DRB4 TAP1 HLA-DRA HLA-DRB3 HLA-DRB1 HLA-A B2M BIOCARTA_S1P_PATHWAY%MSIGDB_C2%BIOCARTA_S1P_PATHWAY BIOCARTA_S1P_PATHWAY LDLR MBTPS1 MBTPS2 SREBF2 LIMA1 HMGCS1 PID_TRAIL_PATHWAY%MSIGDB_C2%PID_TRAIL_PATHWAY PID_TRAIL_PATHWAY PIK3CD MAPK1 TNFRSF10C PIK3R3 PIK3R2 TNFRSF10B TNFRSF10A TNFRSF10D IKBKB PIK3R1 MAP2K4 MAP3K1 CHUK TRADD TRAF2 SMPD1 RIPK1 IKBKG MAPK3 CASP10 PIK3CA TNFSF10 DAP3 MAPK8 CASP8 FADD BIOCARTA_NFKB_PATHWAY%MSIGDB_C2%BIOCARTA_NFKB_PATHWAY BIOCARTA_NFKB_PATHWAY TNF NFKB1 MAP3K7IP1 IKBKB NFKBIA MAP3K1 CHUK TNFAIP3 RELA IL1A IL1R1 TRADD TNFRSF1A FADD MAP3K7 TRAF6 RIPK1 IKBKG MYD88 TNFRSF1B MAP3K14 PID_CIRCADIAN_PATHWAY%MSIGDB_C2%PID_CIRCADIAN_PATHWAY PID_CIRCADIAN_PATHWAY NONO NR1D1 CSNK1E NPAS2 PER2 PER1 CRY2 WDR5 CRY1 TIMELESS BHLHB2 ATR CHEK1 BIOCARTA_RARRXR_PATHWAY%MSIGDB_C2%BIOCARTA_RARRXR_PATHWAY BIOCARTA_RARRXR_PATHWAY GTF2A1 KAT2B NCOA1 TBP NCOR2 RXRA RARA BIOCARTA_RHO_PATHWAY%MSIGDB_C2%BIOCARTA_RHO_PATHWAY BIOCARTA_RHO_PATHWAY ARHGEF5 ROCK1 MYL2 TLN1 ARHGAP5 ARHGAP4 ARHGEF1 OPHN1 PIP5K1A ARHGEF11 ARHA ARHGAP1 HEL114 STM7 PFN1 BAIAP2 PPP1R12B LIMK1 BIOCARTA_EEA1_PATHWAY%MSIGDB_C2%BIOCARTA_EEA1_PATHWAY BIOCARTA_EEA1_PATHWAY EGFR HGS TF EGF EEA1 TFRC RAB5A BIOCARTA_SPRY_PATHWAY%MSIGDB_C2%BIOCARTA_SPRY_PATHWAY BIOCARTA_SPRY_PATHWAY EGFR MAP2K1 MAPK3 CBL GRB2 MAPK1 SOS1 HRAS EGF SHC1 SPRY4 RAF1 PTPRB SPRY2 SPRY1 PID_S1P_S1P3_PATHWAY%MSIGDB_C2%PID_S1P_S1P3_PATHWAY PID_S1P_S1P3_PATHWAY GNA13 S1PR1 ITGAV MAPK3 GNAZ GNAI3 GNAI1 GNA14 VEGFA GNA15 GNA11 MAPK1 ARHA AKT3 GNAO1 SRC ITGB3 CXCR4 S1PR3 RAC1 FLT1 S1PR2 BIOCARTA_GLEEVEC_PATHWAY%MSIGDB_C2%BIOCARTA_GLEEVEC_PATHWAY BIOCARTA_GLEEVEC_PATHWAY MAP2K1 MAPK3 CRKL PIK3CA JUN MAPK8 STAT5B GRB2 SOS1 MYC HRAS BAD MAP2K4 PIK3R1 MAP3K1 FOS STAT1 RAF1 BCR BIOCARTA_CCR3_PATHWAY%MSIGDB_C2%BIOCARTA_CCR3_PATHWAY BIOCARTA_CCR3_PATHWAY MAP2K1 PRKCA MYL2 MAPK3 GNAS CCL11 ROCK2 CCR3 MAPK1 ARHA HRAS PPP1R12B RAF1 PLCB1 PRKCB LIMK1 PIK3C2G BIOCARTA_MCM_PATHWAY%MSIGDB_C2%BIOCARTA_MCM_PATHWAY BIOCARTA_MCM_PATHWAY CDT1 MCM7 ORC6 CDC6 ORC3 ORC2 MCM5 MCM6 MCM2 CDK2 KITLG CCNE1 MCM3 CDKN1B ORC1L BIOCARTA_CERAMIDE_PATHWAY%MSIGDB_C2%BIOCARTA_CERAMIDE_PATHWAY BIOCARTA_CERAMIDE_PATHWAY MAP2K1 MAPK3 NSMAF NFKB1 AIFM1 MAPK8 BCL2 MAPK1 BAD MAP2K4 MAP3K1 CASP8 BAX RELA TRADD TRAF2 RAF1 SMPD1 TNFRSF1A FADD RIPK1 BIOCARTA_ARAP_PATHWAY%MSIGDB_C2%BIOCARTA_ARAP_PATHWAY BIOCARTA_ARAP_PATHWAY ASAP2 ARFGEF1 ARFGEF2 COPA GBF1 CLTB ASAP1 ARFGAP3 GPLD1 ARF1 CYTH1 ARAP1 CYTH2 ARAP2 BIOCARTA_IFNA_PATHWAY%MSIGDB_C2%BIOCARTA_IFNA_PATHWAY BIOCARTA_IFNA_PATHWAY TYK2 IFNAR1 STAT2 IFNA1 IFNB1 STAT1 IFNAR2 IRF9 JAK1 PID_HDAC_CLASSI_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSI_PATHWAY PID_HDAC_CLASSI_PATHWAY TNF SIRT1 KAT2B RANBP2 HDAC9 HDAC6 RBBP4 NCOR1 TNFRSF1A CREBBP MBD3 GATA2 HDAC7 UBE2I SUMO1 RAN NCOR2 HDAC1 MAX PPARG HDAC3 HDAC10 HDAC11 STAT3 CHD4 HDAC5 NFKBIA CHD3 MBD3L2 SMG5 RELA SIRT4 SIN3B SIRT5 SIN3A SIRT6 SIRT7 SIRT2 SIRT3 SAP30 ZFPM1 FKBP3 HDAC8 GATA1 SAP18 RBBP7 NFKB1 MTA2 SMURF1 MBD2 GATAD2B GATAD2A TFCP2 MXD1 HDAC2 YY1 EP300 BIOCARTA_FCER1_PATHWAY%MSIGDB_C2%BIOCARTA_FCER1_PATHWAY BIOCARTA_FCER1_PATHWAY NFATC2 NFATC1 PPP3CA PPP3CC CALM1 JUN MAPK1 SYK SHC1 PIK3R1 MAP2K4 NFATC4 MAP3K1 LYN BTK MAP2K1 MAPK3 PLCG1 PIK3CA MAPK8 FCER1A FCER1G GRB2 MS4A2 SOS1 HRAS NFATC3 FOS RAF1 VAV1 PRKCB PID_TRKR_PATHWAY%MSIGDB_C2%PID_TRKR_PATHWAY PID_TRKR_PATHWAY DOCK1 SQSTM1 DYNLT1 TIAM1 NRAS NGFR NGF MAPK1 KRAS NTRK1 SHC2 CDC42 RAP1A RAPGEF1 CRK CCND1 RASGRF1 SHC1 STAT3 PIK3R1 PRKCZ ELMO1 RAC1 MAP2K1 PTPN11 GAB2 MAPK3 CRKL PLCG1 PIK3CA PRKCI MCF2L GRB2 SOS1 MATK HRAS FRS2 ARHA FRS3 FAIM SHC3 MAGED1 NTF4 NTF3 SH2B1 NTRK3 ARHG RIT1 RIT2 NTRK2 BDNF PID_ERBB1_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_ERBB1_DOWNSTREAM_PATHWAY PID_ERBB1_DOWNSTREAM_PATHWAY ZFP36 EGFR KSR1 MYL11 SH2D2A MAPK7 WASL WASF2 MAP2K5 CYFIP2 ARPC1B MAP3K2 NCKAP1 ACTR3 EGR1 PPP5C ACTR2 CREB1 NRAS RPS6KA5 MAPK1 MAPKAP1 ATF1 MLST8 MAP2K4 RICTOR BRAF SRC MAP3K1 ARPC4 KRAS ARPC5 IQGAP1 BAIAP2 ARPC2 ARPC3 VAV2 CDC42 HEL-S-34 FOS PRKCA RALA SFN RIN1 PLD2 JUN PIK3CD PIK3R3 PIK3R2 MAPK9 HEL2 BAD STAT3 PIK3R1 PPP2R2A PPP2R1A PRKCZ PPP2CA RAB5A RAC1 RPS6 MAP2K1 MAPK3 PDPK1 MTOR PIK3CA MAPK8 YWHAQ GRB2 SOS1 HEL-S-1 F2RL2 HRAS BCL2L1 MAP2K2 YWHAG EGF ATF2 YWHAZ RAF1 STAT1 SMAD1 USP6NL MEF2C ARF4 BRK1 RPS6KA4 RPS6KA3 BIOCARTA_TEL_PATHWAY%MSIGDB_C2%BIOCARTA_TEL_PATHWAY BIOCARTA_TEL_PATHWAY EGFR PRKCA TNKS IGF1R XRCC5 TERF1 TEP1 BCL2 MYC RB1 KRAS PPP2CA TERT BIOCARTA_PCAF_PATHWAY%MSIGDB_C2%BIOCARTA_PCAF_PATHWAY BIOCARTA_PCAF_PATHWAY ATF2 NFKB1 KAT2B IRF4 RELA JUN IRF3 CREBBP IRF2 IRF1 IRF7 HMGB1 BIOCARTA_MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_MAPK_PATHWAY BIOCARTA_MAPK_PATHWAY MAPK7 MAP2K5 MAP3K2 PAK1 CREB1 RPS6KA5 MAPK1 RPS6KA2 MAP3K8 MAP3K6 MAP2K3 CEBPA MAPK13 MAPK6 MAP4K2 MAPK4 MAP2K4 MAPK12 MAP3K1 RPS6KB2 CHUK MAP3K10 MAP3K13 TRADD TRAF2 MAPK11 RIPK1 MAP3K12 MAP3K14 MAP2K6 FOS RPS6KA1 JUN SP1 MAX MYC MAPK9 MAPK14 IKBKB SHC1 NFKBIA MAPK10 RELA MAP3K7 RAC1 HEL-S-31 MAP2K1 MAPK3 TGFB1 NFKB1 RPS6KB1 TGFBR1 MAPK8 GRB2 HRAS MAP2K2 MAP3K11 ATF2 MAPKAPK3 MAP3K5 RAF1 STAT1 MAPKAPK2 RAPGEF2 MAPKAPK5 MAP4K3 RPS6KA4 RPS6KA3 MAP4K1 PID_FOXO_PATHWAY%MSIGDB_C2%PID_FOXO_PATHWAY PID_FOXO_PATHWAY SIRT1 CCNB1 RALA RBL2 KAT2B SFN RAN GADD45A MAPK9 HEL2 IKBKB CHUK MAPK10 BCL6 RALB ZFAND5 SGK1 BCL2L11 CSNK1G3 CSNK1D FOXO3A FBXO32 CREBBP CSNK1G2 TNFSF6 CSNK1G1 SKP2 FOXO4 CDK2 FOXO1 MAPK8 YWHAQ CSNK1E HEL-S-1 CSNK1A1 YWHAG CDKN1B CTNNB1 G6PC1 PLK1 YWHAZ EP300 PID_TCR_JNK_PATHWAY%MSIGDB_C2%PID_TCR_JNK_PATHWAY PID_TCR_JNK_PATHWAY LCP2 CRKL CRK JUN MAPK8 MAP3K8 MAP2K4 MAP3K1 LAT MAP3K7 MAP4K1 PRKCB GRAP2 BIOCARTA_ATRBRCA_PATHWAY%MSIGDB_C2%BIOCARTA_ATRBRCA_PATHWAY BIOCARTA_ATRBRCA_PATHWAY TREX1 NBN RAD51 ATM FANCA MRE11A HUS1 FANCC FANCE FANCG BRCA1 FANCF RAD50 FANCD2 RAD17 CHEK2 RAD1 BRCA2 ATR CHEK1 RAD9A PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY%MSIGDB_C2%PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGFR WASL PAK1 NRAS PIK3CD MAPK1 PIK3R3 PIK3R2 NCK1 SHC1 STAT3 PIK3R1 SRC KRAS PTPN1 PTPN11 PIP5K1C MAPK3 TLN1 PLCG1 GNAI3 GNAI1 PIK3CA GRB2 SOS1 NCK2 HRAS EGF STAT1 PTPN6 BIOCARTA_SODD_PATHWAY%MSIGDB_C2%BIOCARTA_SODD_PATHWAY BIOCARTA_SODD_PATHWAY TNF CASP8 BIRC3 TRADD TRAF2 BAG4 FADD TNFRSF1A RIPK1 TNFRSF1B BIOCARTA_TOLL_PATHWAY%MSIGDB_C2%BIOCARTA_TOLL_PATHWAY BIOCARTA_TOLL_PATHWAY MAP2K6 PGLYRP1 NFKB1 TLR3 NR1C1 JUN MAPK8 MAP3K7IP1 EIF2AK2 MAP2K3 MAPK14 IKBKB MAP2K4 NFKBIA TLR7 MAP3K1 FOS CHUK RELA MAP3K7 TRAF6 IKBKG MYD88 MAP3K14 BIOCARTA_BARR_MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_BARR_MAPK_PATHWAY BIOCARTA_BARR_MAPK_PATHWAY MAP2K2 KCNA2 ADCY1 MAP2K1 KCNA3 ADRBK1 MAPK3 GNAS RAF1 PLCB1 MAPK1 KCNA1 BIOCARTA_IGF1MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1MTOR_PATHWAY BIOCARTA_IGF1MTOR_PATHWAY EIF2S2 EIF2S1 PDPK1 EIF2S3 MTOR RPS6KB1 EIF4EBP1 IGF1 PIK3CA IGF1R PDK2 PIK3R1 GSK3B PPP2CA EIF2B5 INPPL1 EIF4E PTEN BIOCARTA_NKCELLS_PATHWAY%MSIGDB_C2%BIOCARTA_NKCELLS_PATHWAY BIOCARTA_NKCELLS_PATHWAY MAP2K1 MAPK3 KLRC2 KLRC3 KLRC4 IL18 PIK3CA KLRD1 PAK1 KLRC1 PTK2B SYK ITGB1 PIK3R1 LAT VAV1 HLA-A RAC1 PTPN6 B2M BIOCARTA_FAS_PATHWAY%MSIGDB_C2%BIOCARTA_FAS_PATHWAY BIOCARTA_FAS_PATHWAY PAK1 JUN RIPK2 MAP2K4 MAP3K1 FAS MAP3K7 TNFSF6 CASP10 CASP6 SPTAN1 FAF1 MAPK8 PTPN13 RB1 LMNB2 PRKDC CASP8 CASP3 ARHGDIB LMNA FADD DFFB DFFA PARP1 BIOCARTA_GABA_PATHWAY%MSIGDB_C2%BIOCARTA_GABA_PATHWAY BIOCARTA_GABA_PATHWAY GABRA3 UBQLN1 GABARAP GPHN GABRA2 GABRA6 GABRA5 GABRA4 BIOCARTA_NUCLEARRS_PATHWAY%MSIGDB_C2%BIOCARTA_NUCLEARRS_PATHWAY BIOCARTA_NUCLEARRS_PATHWAY CYP26A1 CYP2C9 CYP24A1 ABCA1 CYP1A2 CYP2E1 NR0B2 ABCG1 NR1H4 NR1H3 NR1C2 NR1i1 NR1B3 RARA RARB PPARG NR1i2 NR1C1 ABCD2 ABCD3 NR1I3 CYP4A22 CYP3A4 CYP27B1 CYP2B6 ABCC3 ABCG5 ABCB1 ABCC2 ABCB4 CYP4A11 CYP4B1 ABCB11 CYP8B1 PID_HES_HEY_PATHWAY%MSIGDB_C2%PID_HES_HEY_PATHWAY PID_HES_HEY_PATHWAY MYOD1 RBPJ KDM1A MAML2 MAML1 GATA6 ASCL1 NCOA1 HDAC1 HEY2 NCOR2 SPEN HES6 NOTCH1 GAA RUNX2 RCAN1 ID1 PTF1A BGLAP NEUROG3 STAT3 RBBP8 NCOR1 MYB CREBBP HES1 GATA1 KDR GHR CTBP1 CAMK2D RB1 CDKN1B GATA4 TCF3 YY1 EP300 TWIST1 PARP1 HIF1A BIOCARTA_MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_MTOR_PATHWAY BIOCARTA_MTOR_PATHWAY EIF4A2 AAG1 PDPK1 MTOR RPS6KB1 EIF4EBP1 PIK3CA EIF4A1 EIF4G1 EIF3A PDK2 TSC1 PIK3R1 RHEB PPP2CA TSC2 EIF4E PTEN BIOCARTA_TCRA_PATHWAY%MSIGDB_C2%BIOCARTA_TCRA_PATHWAY BIOCARTA_TCRA_PATHWAY ZAP70 HLA-DRB5 HLA-DRB4 LCK HLA-DRA FYN HLA-DRB3 CD3G HLA-DRB1 CD3E CD3D PTPRC PID_INTEGRIN3_PATHWAY%MSIGDB_C2%PID_INTEGRIN3_PATHWAY PID_INTEGRIN3_PATHWAY SPP1 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 THY1 VEGFA COL1A1 VTN ITGB3 EDIL3 L1CAM SDC1 F11R CD47 FBN1 PECAM1 HMGB1 SPHK1 ITGAV PLAUR KDR LAMA4 LAMC1 TGFBR2 IBSP FGA SDC4 LAMB1 TNC COL1A2 ITGA2B HEL-S-78p THBS1 CYR61 TGFBI PID_RAC1_REG_PATHWAY%MSIGDB_C2%PID_RAC1_REG_PATHWAY PID_RAC1_REG_PATHWAY RASGRF1 DOCK1 KALRN TIAM1 ARHGEF7 HEL-S-47e ELMO1 DOCK2 DOCK6 VAV2 ARHGAP17 PREX2 RAC1 PREX1 CHN1 RALBP1 SPATA13 TRIO ARHGEF25 SOS1 VAV3 ARHGEF2 ARHGAP1 DEF6 VAV1 BCR RASGRF2 PID_TOLL_ENDOGENOUS_PATHWAY%MSIGDB_C2%PID_TOLL_ENDOGENOUS_PATHWAY PID_TOLL_ENDOGENOUS_PATHWAY LY96 TICAM1 TIRAP TLR3 TLR1 SFTPA1 CD14 S100A9 TLR4 S100A8 ARHA VCAN IKBKB CHUK IRAK1 HSPD1 IRAK4 IRAK2 IKBKG MYD88 HMGB1 BIOCARTA_HIVNEF_PATHWAY%MSIGDB_C2%BIOCARTA_HIVNEF_PATHWAY BIOCARTA_HIVNEF_PATHWAY TNF BIRC2 BIRC3 NFKBIA MAP3K1 FAS CHUK RELA CRADD TRADD MDM2 TRAF2 TNFRSF1A CASP2 RIPK1 TNFSF6 MAP3K14 PSEN1 NFKB1 CASP6 SPTAN1 MAPK8 PSEN2 BCL2 ACTG1 CDK11A RB1 NUMA1 LMNB2 PRKDC CASP9 CASP8 MAP3K5 CASP3 ARHGDIB BAG4 LMNA FADD DFFB DFFA PARP1 TRAF1 APAF1 TNFRSF1B BIOCARTA_PKC_PATHWAY%MSIGDB_C2%BIOCARTA_PKC_PATHWAY BIOCARTA_PKC_PATHWAY PRKCA NFKBIA NFKB1 RELA PLCB1 PRKCB BIOCARTA_ATM_PATHWAY%MSIGDB_C2%BIOCARTA_ATM_PATHWAY BIOCARTA_ATM_PATHWAY NBN RAD51 NFKB1 ATM JUN MAPK8 TP73 GADD45A MRE11A CDKN1A NFKBIA RBBP8 BRCA1 RAD50 RELA MDM2 CHEK2 CHEK1 PID_HDAC_CLASSII_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSII_PATHWAY PID_HDAC_CLASSII_PATHWAY HDAC7 GNG2 ADRBK1 UBE2I SUMO1 RAN GNB1 NCOR2 RANBP2 HDAC3 HDAC9 HEL2 HDAC10 HDAC11 HDAC6 HDAC5 CAMK4 BCL6 GATA1 NR3C1 TUBA1B HEL-S-1 RFXANK TUBB2A BCOR ANKRA2 MEF2C GATA2 BIOCARTA_NEUTROPHIL_PATHWAY%MSIGDB_C2%BIOCARTA_NEUTROPHIL_PATHWAY BIOCARTA_NEUTROPHIL_PATHWAY ITGAM SELL SELE PECAM1 CD44 BIOCARTA_CDK5_PATHWAY%MSIGDB_C2%BIOCARTA_CDK5_PATHWAY BIOCARTA_CDK5_PATHWAY MAP2K2 MAP2K1 CDK5R1 MAPK3 EGR1 RAF1 NGFR CDK5 MAPK1 NGF DPM2 HRAS PID_ILK_PATHWAY%MSIGDB_C2%PID_ILK_PATHWAY PID_ILK_PATHWAY ACTN1 PXN CKAP5 TACC3 JUN CREB1 ARHGEF7 HEL-S-28 RICTOR GSK3B IQGAP1 CDC42 RAC1 RUVBL2 RUVBL1 ZYX SNAI1 NCK2 CTNNB1 AURKA CCND1 ILKAP PPP1R14A GIT2 PPP1R14B TNS1 PPP1R14C PARVA ARHG PARVB PARVG NACA CDC37 ELMO2 PARP1 LIMS1 PID_ARF_3PATHWAY%MSIGDB_C2%PID_ARF_3PATHWAY PID_ARF_3PATHWAY GOSR2 USO1 CLTA AP2A1 AP2M1 PLD2 COPA PIP5K1A GBF1 CLTB ASAP1 ARF1 CYTH2 RAC1 KDELR1 PID_S1P_META_PATHWAY%MSIGDB_C2%PID_S1P_META_PATHWAY PID_S1P_META_PATHWAY SPHK1 GNA13 S1PR1 SPHK2 SGPP1 GNAZ SGPL1 GNAI3 S1PR5 GNAI1 S1PR4 GNA14 GNA15 GNA11 GNAO1 ABCC1 S1PR3 S1PR2 PID_HEDGEHOG_2PATHWAY%MSIGDB_C2%PID_HEDGEHOG_2PATHWAY PID_HEDGEHOG_2PATHWAY ADRBK1 LRPAP1 PIK3CA STIL DHH HHIP PTCH2 IHH PTHLH SMO SHH BOC CDON PTCH1 PIK3R1 ARRB2 GAS1 BIOCARTA_ERYTH_PATHWAY%MSIGDB_C2%BIOCARTA_ERYTH_PATHWAY BIOCARTA_ERYTH_PATHWAY TGFB1 IGF1 CCL3 EPO KITLG IL3 IL6 IL9 IL11 FLT3 IL1A CSF3 CSF2 BIOCARTA_BTG2_PATHWAY%MSIGDB_C2%BIOCARTA_BTG2_PATHWAY BIOCARTA_BTG2_PATHWAY RB1 CHAF1B CCND1 BTG1 CHAF1A BTG2 PRMT1 NGF PID_EPHA_FWDPATHWAY%MSIGDB_C2%PID_EPHA_FWDPATHWAY PID_EPHA_FWDPATHWAY PIK3R5 ROCK1 EFNA1 EFNA5 BLK SRC EPHA7 YES1 EPHA8 LYN EFNA3 EFNA2 EPHA1 EPHA4 c-fgr EPHA3 FYN VAV2 CRKL CRK PLCG1 CBL LCK CDK5 ARHA VAV3 ARHGEF15 EPHA2 PID_ERB_GENOMIC_PATHWAY%MSIGDB_C2%PID_ERB_GENOMIC_PATHWAY PID_ERB_GENOMIC_PATHWAY SMARCA4 NEDD8 NR0B2 HEL-S-62p UBE2M NCOA1 NR0B1 NR3A2 UBA3 DDX54 ZNF14 SMARCE1 BIOCARTA_STAT3_PATHWAY%MSIGDB_C2%BIOCARTA_STAT3_PATHWAY BIOCARTA_STAT3_PATHWAY TYK2 MAPK3 STAT3 MTOR MAPK1 JAK3 JAK1 BIOCARTA_HSP27_PATHWAY%MSIGDB_C2%BIOCARTA_HSP27_PATHWAY BIOCARTA_HSP27_PATHWAY TNF BCL2 CASP9 MAPKAPK3 HSPB2-C11orf52 FAS IL1A CASP3 HEL-S-102 ACTA1 MAPKAPK2 TNFSF6 APAF1 BIOCARTA_PEPI_PATHWAY%MSIGDB_C2%BIOCARTA_PEPI_PATHWAY BIOCARTA_PEPI_PATHWAY CELA3B GRN SLPI ELA2B CELA1 ELANE CXCL8 CELA2A PID_HDAC_CLASSIII_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSIII_PATHWAY PID_HDAC_CLASSIII_PATHWAY SIRT1 MYOD1 KAT2B ACSS2 H4C9 FOXO4 FHL2 FOXO1 HOXA10 MEF2D HIST1H1E ACSS1 TUBA1B PPARGC1A TUBB2A CDKN1A BAX EP300 SIRT7 SIRT2 FOXO3A CREBBP SIRT3 PID_CD8_TCR_PATHWAY%MSIGDB_C2%PID_CD8_TCR_PATHWAY PID_CD8_TCR_PATHWAY PRKCA ZAP70 CD8A NRAS CD3G CD3E CD3D PRKCE MAP3K8 BCL10 SHC1 IKBKB KRAS CHUK LAT PRF1 FYN HLA-A TRAF6 RAP1A IKBKG B2M GRAP2 MAP3K14 LCP2 PDPK1 PLCG1 CBL LCK PAG1 GRB2 CD8B1 SOS1 STIM1 HRAS PTPRC TRPV6 ORAI1 CARD11 CSK PRKCQ CD80 VAV1 PTPN6 PRKCB BIOCARTA_PTEN_PATHWAY%MSIGDB_C2%BIOCARTA_PTEN_PATHWAY BIOCARTA_PTEN_PATHWAY EGFR MAPK3 PDPK1 PIK3CA HEL-S-28 GRB2 MAPK1 SOS1 PDK2 CDKN1B ITGB1 SHC1 PIK3R1 FOXO3A TNFSF6 PTEN PID_P38_GAMMA_DELTA_PATHWAY%MSIGDB_C2%PID_P38_GAMMA_DELTA_PATHWAY PID_P38_GAMMA_DELTA_PATHWAY PKN1 MAP2K6 MAP2K3 MAPK13 EEF2K CCND1 pk MAPK12 SNTA1 PID_FRA_PATHWAY%MSIGDB_C2%PID_FRA_PATHWAY PID_FRA_PATHWAY NFATC2 HMOX1 NFATC1 CCNA2 MMP9 JUN IL6 SP1 LIF BGLAP GJA1 FOSL2 CCL2 FOSL1 CDKN2A PLAUR ITGB4 MMP2 CCND1 TXLNG NFATC3 LAMA3 THBD JUNB COL1A2 JUND USF2 EP300 DCN MGP IVL ATF4 CXCL8 BIOCARTA_AHSP_PATHWAY%MSIGDB_C2%BIOCARTA_AHSP_PATHWAY BIOCARTA_AHSP_PATHWAY UROD UROS HMBS GATA1 ALAS1 CPOX HBB HBA2 ERAF ALAS2 BIOCARTA_IL7_PATHWAY%MSIGDB_C2%BIOCARTA_IL7_PATHWAY BIOCARTA_IL7_PATHWAY NMI PIK3CA IL7 LCK IL7R BCL2 STAT5B PTK2B PIK3R1 EP300 FYN CREBBP JAK3 JAK1 BIOCARTA_PLATELETAPP_PATHWAY%MSIGDB_C2%BIOCARTA_PLATELETAPP_PATHWAY BIOCARTA_PLATELETAPP_PATHWAY COL4A2 F2 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 APP F9 PLG F11 PLAT BIOCARTA_CPSF_PATHWAY%MSIGDB_C2%BIOCARTA_CPSF_PATHWAY BIOCARTA_CPSF_PATHWAY CPSF2 CSTF2 CSTF1 PAPOLA BCL2L2-PABPN1 CPSF4 CPSF1 PABPN1 CPSF3 CSTF3 PID_IL12_2PATHWAY%MSIGDB_C2%PID_IL12_2PATHWAY PID_IL12_2PATHWAY SPHK2 CD8A IL18 IL4 CD3G CD3E CD3D IFNG MAP2K3 IL12B IL12A MAP2K6 CCL4 CCL3 CD8B1 TYK2 STAT4 CCR5 IL12RB1 IL18R1 FOS PPP3CA NOS2 SOCS1 RIPK2 MAPK14 STAT3 IL18RAP IL2RG RELB RELA PPP3R1 IL1R1 HLX TBX21 RAB7A GADD45B GZMA IL1B GADD45G HLA-A NFKB2 B2M TNFSF6 IL2 NFKB1 MTOR LCK IL2RA IL2RB ATF2 STAT1 HLA-DRA BIOCARTA_TCR_PATHWAY%MSIGDB_C2%BIOCARTA_TCR_PATHWAY BIOCARTA_TCR_PATHWAY NFATC2 PRKCA NFATC1 ZAP70 PPP3CA PPP3CC CALM1 JUN CD3G CD3E CD3D SHC1 PIK3R1 MAP2K4 NFATC4 NFKBIA MAP3K1 RELA LAT FYN RAC1 MAP2K1 MAPK3 NFKB1 PLCG1 PIK3CA LCK MAPK8 GRB2 SOS1 HRAS NFATC3 FOS RAF1 VAV1 PRKCB BIOCARTA_CTCF_PATHWAY%MSIGDB_C2%BIOCARTA_CTCF_PATHWAY BIOCARTA_CTCF_PATHWAY CD79A SMAD4 TGFB1 CDKN2A MTOR RPS6KB1 PIK3CA TGFBR1 TGFBR2 TGFBR3 MYC CDKN1B PIK3R1 DKFZp781O1323 PPP2CA MDM2 SMAD1 CTCF PTEN CD79B BIOCARTA_MYOSIN_PATHWAY%MSIGDB_C2%BIOCARTA_MYOSIN_PATHWAY BIOCARTA_MYOSIN_PATHWAY PKN1 GNA13 ROCK1 PRKCA PPP1R12B ARHGAP5 ARHGEF1 PLCB1 PRKCB PID_CDC42_REG_PATHWAY%MSIGDB_C2%PID_CDC42_REG_PATHWAY PID_CDC42_REG_PATHWAY RALBP1 ITSN2 SPATA13 DOCK9 ITSN1 FGD1 ARHGEF25 DOCK10 DOCK11 PLCG1 ARHGEF9 ARHGEF7 MCF2L HEL-S-47e VAV3 APC FARP2 ARHGAP1 DOCK6 VAV2 ARHGAP17 CDC42 PID_PRL_SIGNALING_EVENTS_PATHWAY%MSIGDB_C2%PID_PRL_SIGNALING_EVENTS_PATHWAY PID_PRL_SIGNALING_EVENTS_PATHWAY ROCK1 MAPK3 CCNA2 EGR1 RABGGTB RABGGTA CDK2 PTP4A1 PTP4A2 PTP4A3 CCNE1 ATF5 MAPK1 TUBA1B ARHA CDKN1A ITGA1 ITGB1 SRC RAC1 BIOCARTA_FIBRINOLYSIS_PATHWAY%MSIGDB_C2%BIOCARTA_FIBRINOLYSIS_PATHWAY BIOCARTA_FIBRINOLYSIS_PATHWAY FGA F2 PLG HEL-S-78p CPB2 SERPINB2 PLAT F2R F13A1 PID_NETRIN_PATHWAY%MSIGDB_C2%PID_NETRIN_PATHWAY PID_NETRIN_PATHWAY DOCK1 WASL PAK1 MAPK1 NCK1 CAMK2A PIK3R1 SRC YES1 AGAP2 ELMO1 FYN CDC42 RAC1 MAP2K1 TRIO MAPK3 PLCG1 PIK3CA MAP1B ARHA HEL-S-36 MAP2K2 NTN1 UNC5A UNC5B DCC PID_FCER1_PATHWAY%MSIGDB_C2%PID_FCER1_PATHWAY PID_FCER1_PATHWAY PXN MAPK1 MAP2K4 MAP3K1 CHUK BTK LAT IKBKG SPHK1 LCP2 S1PR1 PTPN13 FOS PRKCB NFATC2 PLD2 JUN SYK IKBKB SHC1 PIK3R1 RELA LYN FYN ITK MAP2K1 PTPN11 FER GAB2 MAPK3 NFKB1 PLCG1 PIK3CA CBL MAPK8 FCER1A FCER1G GRB2 MS4A2 SOS1 HRAS MAP2K2 WIPF1 LAT2 DOK1 HCLS1 RAF1 PLPP1 PLA2G1B VAV1 FCGR2B BIOCARTA_COMP_PATHWAY%MSIGDB_C2%BIOCARTA_COMP_PATHWAY BIOCARTA_COMP_PATHWAY C1R C4B_2 C8A C2 C4A C6 C7 C9 MASP2 MASP1 MBL2 C1QC HEL-S-62p CFD C1QB C1QA C1S BIOCARTA_SET_PATHWAY%MSIGDB_C2%BIOCARTA_SET_PATHWAY BIOCARTA_SET_PATHWAY PRF1 GZMA DFFB SET CREBBP DFFA APEX1 HMGB2 BIOCARTA_AMAN_PATHWAY%MSIGDB_C2%BIOCARTA_AMAN_PATHWAY BIOCARTA_AMAN_PATHWAY FUT4 FUT6 FUT5 FUT7 MAN2A2 MAN1A2 FUT9 B3GALT2 B3GALT1 ST8SIA4 MAN1A1 MAN2C1 SIAT4C PID_BETA_CATENIN_NUC_PATHWAY%MSIGDB_C2%PID_BETA_CATENIN_NUC_PATHWAY PID_BETA_CATENIN_NUC_PATHWAY TNIK MMP9 APC TBXT CAMK4 TCF7L1 ZCCHC12 CHD8 CBY1 RUVBL2 MED12 SALL4 PITX2 MYOG CDKN2A TLE4 TLE2 CTNNBIP1 KRT1 AXIN2 TLE5 DKK4 FGF7A MDFIC DVL3 TBL1XR1 LEF1 CACNA1G IGF2BP1 COX2 TBL1X TCF7L2 CCND1 CDX4 CDX1 KCNIP4 KLF4 SKP1 BCL9 SP5 TCF4 NEUROG1 CYR61 DKK1 MYF5 INCENP SFN JUN HDAC1 ID2 MYC HEL2 SMARCA4 TERT SNAI2 CCND2 CTBP1 YWHAQ HEL-S-1 MMP2 YWHAG VCAN CTNNB1 TRRAP HDAC2 YWHAZ EP300 CXCL8 BIOCARTA_GH_PATHWAY%MSIGDB_C2%BIOCARTA_GH_PATHWAY BIOCARTA_GH_PATHWAY MAP2K1 PRKCA MAPK3 INSR PLCG1 SLC2A4 PIK3CA GHR GH1 STAT5B SOCS1 GRB2 MAPK1 SOS1 HRAS HNF1A SHC1 PIK3R1 RAF1 RPS6KA1 IRS1 PTPN6 PRKCB BIOCARTA_CLASSIC_PATHWAY%MSIGDB_C2%BIOCARTA_CLASSIC_PATHWAY BIOCARTA_CLASSIC_PATHWAY C1R C4B_2 C8A C2 C4A C6 C7 C9 C1QC HEL-S-62p C1QB C1QA C1S BIOCARTA_HES_PATHWAY%MSIGDB_C2%BIOCARTA_HES_PATHWAY BIOCARTA_HES_PATHWAY HES1 HNF1A RBPJ GSK3B DVL1 FZD1 HEY2 HES7 WNT1 NOTCH2 NOTCH1 BIOCARTA_IL2RB_PATHWAY%MSIGDB_C2%BIOCARTA_IL2RB_PATHWAY BIOCARTA_IL2RB_PATHWAY NMI SOCS3 SOCS1 MAPK1 MYC SYK BAD SHC1 PIK3R1 IL2RG FAS JAK3 TNFSF6 JAK1 MAPK3 CRKL RPS6KB1 PIK3CA CBL IL2RA IL2RB BCL2 STAT5B GRB2 SOS1 HRAS FOS RAF1 IRS1 IKZF3 PTPN6 HEL-S-69p PID_IL5_PATHWAY%MSIGDB_C2%PID_IL5_PATHWAY PID_IL5_PATHWAY IL5RA PTPN11 CISH PIK3R1 LYN PIK3CA STAT5B IL5 PIM1 GRB2 CSF2RB SDCBP PID_LKB1_PATHWAY%MSIGDB_C2%PID_LKB1_PATHWAY PID_LKB1_PATHWAY BRSK1 CRTC2 AKT1S1 CAB39 STK11 MAP2 SFN MARK4 STK11IP STRADA STRADB ETV4 CREB1 STK26 SIK3 SIK1 SIK2 MYC HEL2 MLST8 TSC1 GSK3B PRKAG1 SMAD4 SMARCD3 MTOR EZR PSEN2 YWHAQ HEL-S-130P HEL-S-1 PRKAA1 YWHAG PRKAA2 YWHAZ TSC2 PRKAB1 CDC37 RPTOR PID_DNA_PK_PATHWAY%MSIGDB_C2%PID_DNA_PK_PATHWAY PID_DNA_PK_PATHWAY PNKP APLF CSNK2A2 DNTT POLL PRKDC APTX CSNK2B NHEJ1 XRCC5 CSNK2A1 POLM PID_TCR_PATHWAY%MSIGDB_C2%PID_TCR_PATHWAY PID_TCR_PATHWAY NRAS CD3G CD3E CD3D PRKCE MAP3K8 NCK1 KRAS CHUK LAT CDC42 TRAF6 IKBKG RAP1A GRAP2 MAP3K14 LCP2 FLNA PAG1 STIM1 TRPV6 ORAI1 CARD11 CSK PTPN6 PRKCB PRKCA ZAP70 BCL10 IKBKB SHC1 SLA2 STK39 WAS FYB1 FYN ITK PTEN PTPN11 GAB2 PDPK1 PLCG1 LCK CBL GRB2 SOS1 HRAS PTPRC PRKCQ CD80 HLA-DRA VAV1 MAP4K1 PID_TCR_RAS_PATHWAY%MSIGDB_C2%PID_TCR_RAS_PATHWAY PID_TCR_RAS_PATHWAY MAP3K8 MAP2K1 PRKCA MAPK3 BRAF KRAS FOS RAF1 NRAS MAPK1 PRKCB HRAS BIOCARTA_LEPTIN_PATHWAY%MSIGDB_C2%BIOCARTA_LEPTIN_PATHWAY BIOCARTA_LEPTIN_PATHWAY PRKAA1 PRKAB2 PRKAA2 PRKAG2 PRKAG3 PRKAG1 LEPR PRKAB1 ACACA CPT1A LEP BIOCARTA_TOB1_PATHWAY%MSIGDB_C2%BIOCARTA_TOB1_PATHWAY BIOCARTA_TOB1_PATHWAY SMAD4 TGFB1 IL2 TGFBR1 TGFBR2 IL4 IL2RA TGFBR3 CD3G CD3E CD3D IFNG TOB2 TOB1 PID_S1P_S1P4_PATHWAY%MSIGDB_C2%PID_S1P_S1P4_PATHWAY PID_S1P_S1P4_PATHWAY GNA13 MAPK3 GNAO1 GNAZ PLCG1 GNAI3 S1PR5 S1PR4 GNAI1 CDC42 MAPK1 ARHA BIOCARTA_FOSB_PATHWAY%MSIGDB_C2%BIOCARTA_FOSB_PATHWAY BIOCARTA_FOSB_PATHWAY GRIA2 JUND CDK5 PPP1R1B FOSB BIOCARTA_LECTIN_PATHWAY%MSIGDB_C2%BIOCARTA_LECTIN_PATHWAY BIOCARTA_LECTIN_PATHWAY C4B_2 C8A C2 C4A C6 C7 HEL-S-62p C9 MASP2 MASP1 MBL2 BIOCARTA_GHRELIN_PATHWAY%MSIGDB_C2%BIOCARTA_GHRELIN_PATHWAY BIOCARTA_GHRELIN_PATHWAY IGFBP5 SST GHRH IGFBP1 IGFBP2 GHRL IGFALS IGFBP6 IGF1 RAPGEF5 GH1 IGFBP4 BIOCARTA_IL6_PATHWAY%MSIGDB_C2%BIOCARTA_IL6_PATHWAY BIOCARTA_IL6_PATHWAY MAP2K1 PTPN11 CEBPB MAPK3 JUN IL6 GRB2 IL6ST SOS1 IL6R CSNK2A1 HRAS SHC1 STAT3 FOS RAF1 JAK3 JAK1 PID_IL27_PATHWAY%MSIGDB_C2%PID_IL27_PATHWAY PID_IL27_PATHWAY TNF TGFB1 IL2 IL18 EBI3 IL27 GATA3 IL27RA IL6 IL6ST IFNG TYK2 IL17A STAT2 STAT4 STAT3 IL12RB1 IL12B IL12A STAT1 TBX21 IL1B JAK1 BIOCARTA_DREAM_PATHWAY%MSIGDB_C2%BIOCARTA_DREAM_PATHWAY BIOCARTA_DREAM_PATHWAY MAPK3 PRKAR1B CREM PRKAR1A FOS PRKACG JUN CREB1 KCNIP3 OPRK1 BIOCARTA_ECM_PATHWAY%MSIGDB_C2%BIOCARTA_ECM_PATHWAY BIOCARTA_ECM_PATHWAY MAP2K1 ROCK1 MYL2 MAPK3 TLN1 PIK3CA ARHGAP5 MAPK1 ARHA HRAS ITGB1 SHC1 PIK3R1 PFN1 RAF1 FYN BIOCARTA_PTDINS_PATHWAY%MSIGDB_C2%BIOCARTA_PTDINS_PATHWAY BIOCARTA_PTDINS_PATHWAY PDPK1 PLCG1 AP2A1 RPS6KB1 AP2M1 PFKM PFKL GSK3A PRKCE PFKP ARHGEF2 ARF1 BAD GSK3B PRKCZ LYN BTK EEA1 RAB5A VAV2 RAC1 PID_INTEGRIN_A9B1_PATHWAY%MSIGDB_C2%PID_INTEGRIN_A9B1_PATHWAY PID_INTEGRIN_A9B1_PATHWAY CSF2RA PXN SPP1 NOS2 VCAM1 VEGFC VEGFD ADAM12 VEGFA KCNJ15 F13A1 ADAM2 ADAM15 ADAM8 ITGB1 PAOX SRC TNC RAC1 CSF2 BIOCARTA_CK1_PATHWAY%MSIGDB_C2%BIOCARTA_CK1_PATHWAY BIOCARTA_CK1_PATHWAY CDK5R1 PRKAR1B PPP3CA PRKAR1A DRD1 DRD2 PRKACG PPP2CA PLCB1 CSNK1D CDK5 PPP1R1B BIOCARTA_IL10_PATHWAY%MSIGDB_C2%BIOCARTA_IL10_PATHWAY BIOCARTA_IL10_PATHWAY TNF IL10 HMOX1 STAT3 HEL-S-10 IL1A IL10RB IL10RA STAT1 IL6 JAK1 PID_IL23_PATHWAY%MSIGDB_C2%PID_IL23_PATHWAY PID_IL23_PATHWAY IL17F TNF NOS2 IL18 SOCS3 IL6 CD3E IFNG CXCL9 IL17A STAT3 PIK3R1 NFKBIA IL18RAP IL12B RELA IL1B CCL2 IL2 NFKB1 PIK3CA TYK2 STAT4 IL12RB1 IL18R1 IL23R STAT1 IL24 ALOX12B CXCL1 MPO IL19 IL23A PID_INTEGRIN4_PATHWAY%MSIGDB_C2%PID_INTEGRIN4_PATHWAY PID_INTEGRIN4_PATHWAY LAMB3 LAMA5 LAMB2 LAMA1 ITGB4 LAMB1 LAMA3 LAMC2 LAMC1 ITGA6 BIOCARTA_AMI_PATHWAY%MSIGDB_C2%BIOCARTA_AMI_PATHWAY BIOCARTA_AMI_PATHWAY PROS1 F7 COL4A2 F2 COL4A1 COL4A4 COL4A3 SERPINC1 COL4A6 COL4A5 F2R FGA F10 PLG TFPI HEL-S-78p PROC PLAT ERAF PID_TCR_CALCIUM_PATHWAY%MSIGDB_C2%PID_TCR_CALCIUM_PATHWAY PID_TCR_CALCIUM_PATHWAY NFATC2 NFATC1 AKAP5 CABIN1 PPP3CA CHP1 BATF3 IL4 JUN IL3 IFNG RCAN1 CD40LG PPP3R1 TNFSF6 CSF2 FOSL1 IL2 POU2F1 IL2RA FKBP1A PTGS2 NFATC3 FOS JUNB BIOCARTA_LDL_PATHWAY%MSIGDB_C2%BIOCARTA_LDL_PATHWAY BIOCARTA_LDL_PATHWAY CCL2 LDLR CSF1 ACAT1 IL6 LPL BIOCARTA_CACAM_PATHWAY%MSIGDB_C2%BIOCARTA_CACAM_PATHWAY BIOCARTA_CACAM_PATHWAY CAMK4 CAMK1 CAMK1G CAMKK1 CALM1 CAMKK2 CREB1 PID_ERA_GENOMIC_PATHWAY%MSIGDB_C2%PID_ERA_GENOMIC_PATHWAY PID_ERA_GENOMIC_PATHWAY CALCOCO1 MPG SRA1 PHB2 SET PDIA2 DSCAM POU4F1 LMO4 POU4F2 AP1B1 SAFB LCOR PGR TFF1 NCOA7 CHUK NCOR1 TRIM59 PRDM15 ATP5J HSF2 NDUFV3 NR3A2 XBP1 ABCA3 UBA3 DDX54 EBAG9 CEBPB KLRC3 AXIN2 NR0B1 HEL-S-130P CD82 GREB1 CCND1 NEDD8 HEL-S-62p UBE2M NR0B2 NCOA1 JUN MED1 NCOR2 HDAC1 PRL MYC COL18A1 SMAD4 BRCA1 PCNA EP300 HEL-S-44 BIOCARTA_CD40_PATHWAY%MSIGDB_C2%BIOCARTA_CD40_PATHWAY BIOCARTA_CD40_PATHWAY NFKB1 CD40 IKBKB CD40LG NFKBIA MAP3K1 CHUK TNFAIP3 RELA TRAF3 TRAF6 IKBKAP IKBKG MAP3K14 PID_ATR_PATHWAY%MSIGDB_C2%PID_ATR_PATHWAY PID_ATR_PATHWAY MCM7 CCNA2 MCM2 PPP2R1A PPP2CA MDM2 BRCA2 CHEK1 SMARCAL1 CEP164 NBN PPP2R2B ATRIP RAD51 RFC3 CDC6 RFC4 FBXW11 RFC2 CDK2 RPA1 HEL-S-1 HUS1 TIMELESS PLK1 YWHAZ FANCD2 RAD17 RAD1 ATR TOPBP1 CLSPN RAD9A BIOCARTA_AGPCR_PATHWAY%MSIGDB_C2%BIOCARTA_AGPCR_PATHWAY BIOCARTA_AGPCR_PATHWAY PRKCA GRK4 PRKAR1B GNAS PRKAR1A PRKACG PRKCB PID_AVB3_INTEGRIN_PATHWAY%MSIGDB_C2%PID_AVB3_INTEGRIN_PATHWAY PID_AVB3_INTEGRIN_PATHWAY ROCK1 PXN SPP1 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 HEL-S-28 MAPK1 SRC ITGB3 F11R ITGAV COL16A1 TLN1 COL14A1 COL12A1 KDR PIK3C2A COL10A1 IGF1R TEM5 COL2A1 COL6A1 ANGPTL3 COL8A2 COL8A1 COL13A1 COL11A2 MFGE8 COL5A2 COL9A1 COL9A3 COL9A2 PI4KB HEL114 IRS1 VEGFA COL1A1 PIK3R1 CSF1R VTN CSF1 EDIL3 SDC1 RAC1 PTPN11 MAPK3 COL17A1 RPS6KB1 PIK3CA CBL TGFBR2 PTK2B ARHA VAV3 CDKN1B CASP8 COL3A1 COL1A2 FGF2 PID_EPHA2_FWD_PATHWAY%MSIGDB_C2%PID_EPHA2_FWD_PATHWAY PID_EPHA2_FWD_PATHWAY EFNA1 PIK3CA CBL ARHGAP35 PAK1 TIAM1 GRB2 ARHA VAV3 SHC1 PIK3R1 SRC VAV2 INPPL1 RAC1 EPHA2 BIOCARTA_PARKIN_PATHWAY%MSIGDB_C2%BIOCARTA_PARKIN_PATHWAY BIOCARTA_PARKIN_PATHWAY UBE2F GPR37 SUMO1 UBE2G1 UBE2G2 SNCAIP SEPT5 SNCA BIOCARTA_VITCB_PATHWAY%MSIGDB_C2%BIOCARTA_VITCB_PATHWAY BIOCARTA_VITCB_PATHWAY COL4A2 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 SLC23A2 SLC23A1 SLC2A3 PID_INSULIN_PATHWAY%MSIGDB_C2%PID_INSULIN_PATHWAY PID_INSULIN_PATHWAY EIF4EBP1 INS EXOC7 NCK1 SHC1 PIK3R1 PRKCZ EXOC4 SGK1 PARD6A EXOC3 GRB10 EXOC6 FOXO3A EXOC5 EXOC2 PTPN1 EXOC1 RAPGEF1 PTPN11 HEL-S-42 PDPK1 INSR CRK RPS6KB1 PIK3CA CBL PRKCI TRIP10 GRB14 GRB2 SOS1 F2RL2 NCK2 HRAS DOK1 IRS1 SH2B2 PID_IL8_CXCR1_PATHWAY%MSIGDB_C2%PID_IL8_CXCR1_PATHWAY PID_IL8_CXCR1_PATHWAY PRKCA GNG2 ADRBK1 PDPK1 CBL GNA14 GNB1 GNA15 PRKCE PLCB3 ARRB2 LYN RAB5A c-fgr PLCB1 PLCB2 CXCL8 PRKCB CXCR1 PID_BETA_CATENIN_DEG_PATHWAY%MSIGDB_C2%PID_BETA_CATENIN_DEG_PATHWAY PID_BETA_CATENIN_DEG_PATHWAY AXIN1 AXIN2 DVL1 DVL2 DVL3 FZD5 CSNK1E GSK3A CSNK1A1 WNT3A APC CTNNB1 GSK3B SKP1 LRP6 CSNK1D PID_IL3_PATHWAY%MSIGDB_C2%PID_IL3_PATHWAY PID_IL3_PATHWAY SRP9 PTPN11 CNKSR1 CEBPB CISH GAB2 OSM PRKACG PIK3CA IL3 HDAC1 STAT5B PIM1 GRB2 BCL2L1 ID1 YWHAG SHC1 PIK3R1 YWHAZ CSF2RB IL3RA PID_AP1_PATHWAY%MSIGDB_C2%PID_AP1_PATHWAY PID_AP1_PATHWAY IL10 MMP9 EGR1 IL4 CREB1 IL6 TH IL5 IFNG BCL2L11 FOSL2 CSF2 CCL2 CDKN2A CDC2 NR3C1 ELF1 TCF7L2 CCND1 EDN1 FOS NFATC3 JUNB JUND CYR61 ATF3 GATA2 MAFG HIF1A NFATC2 CRTC1 NFATC1 DMP1 MT2A CBFB NTS BAG1 PENK FABP4 JUN TRIP6 COPS5 SP1 MYC GJA1 ACTA1 MYB HLA-A PTEN FOSB NPPA FOSL1 TGFB1 IL2 TIMP1 CDKN1B CTNNB1 ATF2 COL1A2 EP300 CXCL8 PID_HNF3A_PATHWAY%MSIGDB_C2%PID_HNF3A_PATHWAY PID_HNF3A_PATHWAY JUN SERPINA1 INS SFTPA2 SP1 C4BPB SFTPD CYP2C18 DSCAM NKX3-1 AP1B1 GCG NR2F2 PISD NFIA NFIB TFF1 VTN SCGB1A1 PRDM15 ATP5J NDUFV3 COL18A1 XBP1 CREBBP KLK3 APOB CEBPB SFTPA1 POU2F1 FOXA1 SHH CDKN1B BRCA1 FOS FOXA3 EP300 FOXA2 HEL-S-44 BIOCARTA_MALATEX_PATHWAY%MSIGDB_C2%BIOCARTA_MALATEX_PATHWAY BIOCARTA_MALATEX_PATHWAY SLC25A1 ACLY PC PDHA1 ME1 CS SLC25A11 HEL-S-32 BIOCARTA_CDMAC_PATHWAY%MSIGDB_C2%BIOCARTA_CDMAC_PATHWAY BIOCARTA_CDMAC_PATHWAY MAP2K1 PRKCA TNF MAPK3 NFKB1 JUN MAPK1 MYC HRAS NFKBIA FOS RELA RAF1 PLCB1 CUZD1 PRKCB BIOCARTA_SM_PATHWAY%MSIGDB_C2%BIOCARTA_SM_PATHWAY BIOCARTA_SM_PATHWAY SNRPG SNRPA1 SNRPB2 SNRPE SNRPD3 SNRPF DKFZp434N041 SNRPC SNRPA SNRPB U2AF1 SNRPD2 SNRPD1 PID_ALK1_PATHWAY%MSIGDB_C2%PID_ALK1_PATHWAY PID_ALK1_PATHWAY SMAD4 TGFB1 MAPK3 TGFBR1 TGFBR2 ACVRL1 FKBP1A INHBA ACVR2B TLX2 SMAD9 ACVR2A MAPK1 ID1 BMPR2 CSNK2B ARRB2 DKFZp781O1323 ACVR1 SMAD1 ENG BIOCARTA_MCALPAIN_PATHWAY%MSIGDB_C2%BIOCARTA_MCALPAIN_PATHWAY BIOCARTA_MCALPAIN_PATHWAY EGFR MYL2 PRKAR1B TLN1 PRKAR1A CAPNS1 PRKACG EZR CAPNS2 HRAS CXCR3 ITGB1 EGF ACTA1 BIOCARTA_HSWI_SNF_PATHWAY%MSIGDB_C2%BIOCARTA_HSWI_SNF_PATHWAY BIOCARTA_HSWI_SNF_PATHWAY SMARCD1 SMARCC1 SMARCA4 SMARCC2 GTF2A1 ARID1A NR3C1 NF1 TBP PS1TP5BP1 SMARCE1 BIOCARTA_TFF_PATHWAY%MSIGDB_C2%BIOCARTA_TFF_PATHWAY BIOCARTA_TFF_PATHWAY EGFR MAPK3 PIK3CA GHR GH1 GRB2 ERBB2 MAPK1 SOS1 MUC2 ARHA HRAS TFF2 BAD CTNNB1 ITGB1 SHC1 PIK3R1 CASP9 TFF1 TFF3 APAF1 BIOCARTA_CARM1_PATHWAY%MSIGDB_C2%BIOCARTA_CARM1_PATHWAY BIOCARTA_CARM1_PATHWAY PRKAR1B CARM1 PRKAR1A PRKACG CREB1 EP300 RXRA CREBBP RARA BIOCARTA_BCELLSURVIVAL_PATHWAY%MSIGDB_C2%BIOCARTA_BCELLSURVIVAL_PATHWAY BIOCARTA_BCELLSURVIVAL_PATHWAY DPF2 ZBTB7A ITGB1 CCT4 PIK3R1 FOS MTOR PIK3CA CASP3 JUND BIRC5 BIOCARTA_PROTEASOME_PATHWAY%MSIGDB_C2%BIOCARTA_PROTEASOME_PATHWAY BIOCARTA_PROTEASOME_PATHWAY PSMB6 HEL-S-276 PSMA4 PSMB2 RPN2 PSMB3 PSMA2 RPN1 UBE3A UBE2A BIOCARTA_PLCD_PATHWAY%MSIGDB_C2%BIOCARTA_PLCD_PATHWAY BIOCARTA_PLCD_PATHWAY PRKCA ADRA1B PRKCB BIOCARTA_TCAPOPTOSIS_PATHWAY%MSIGDB_C2%BIOCARTA_TCAPOPTOSIS_PATHWAY BIOCARTA_TCAPOPTOSIS_PATHWAY CCR5 FAS CD3G CD3E TNFSF6 CD3D BIOCARTA_RHODOPSIN_PATHWAY%MSIGDB_C2%BIOCARTA_RHODOPSIN_PATHWAY BIOCARTA_RHODOPSIN_PATHWAY PDE6G RHO SAG PDE6A SLC25A22 GRK1 SLC25A18 RCVRN BIOCARTA_TPO_PATHWAY%MSIGDB_C2%BIOCARTA_TPO_PATHWAY BIOCARTA_TPO_PATHWAY MAP2K1 PRKCA MAPK3 MPL PLCG1 THPO PIK3CA JUN STAT5B GRB2 SOS1 CSNK2A1 HRAS SHC1 STAT3 PIK3R1 FOS STAT1 RAF1 PRKCB PID_SHP2_PATHWAY%MSIGDB_C2%PID_SHP2_PATHWAY PID_SHP2_PATHWAY EGFR SDC2 NRAS IL6 NGF IFNG LMO4 KRAS NTRK1 AFDN KDR IFNGR1 IGF1R PAG1 ANGPT1 IRS1 VEGFA SHC1 PIK3R1 IL2RG JAK3 JAK1 MAP2K1 PTPN11 GAB2 IL2 GNAI3 PIK3CA GNAI1 LCK ARHGAP35 IL2RA IL2RB IL6ST GRB2 IL6R SOS1 HRAS FRS2 ARHA MAP2K2 FRS3 EGF NTF4 NTF3 NTRK3 RAF1 STAT1 NTRK2 BDNF PID_CERAMIDE_PATHWAY%MSIGDB_C2%PID_CERAMIDE_PATHWAY PID_CERAMIDE_PATHWAY TNF KSR1 MADD SPHK2 CYCS BIRC3 AIFM1 PAWR PRKRA MAPK1 EIF2AK2 PDGFA MYC BAD MAP2K4 NFKBIA MAP3K1 PRKCZ BAX RELA CRADD TRADD TRAF2 SMPD1 TNFRSF1A RIPK1 HEL-S-31 MAP2K1 MAPK3 NFKB1 MAPK8 BCL2 HEL-S-130P MAP2K2 EGF CASP8 RAF1 BAG4 FADD PID_PDGFRB_PATHWAY%MSIGDB_C2%PID_PDGFRB_PATHWAY PID_PDGFRB_PATHWAY KSR1 WASL WASF2 ARPC1B ACTR3 ACTR2 PAK1 SLA NRAS DKFZp686P11128 ACTN4 DOCK4 MAPK1 MYOCD HEL-S-47e ACTA2 NHERF2 SIPA1 NCK1 BRAF BLK ARPC4 KRAS YES1 ARPC5 BAIAP2 ARPC2 ARPC3 c-fgr PIN1 RAB4A FOS PRKCA EIF2AK2 MYC HEL2 SHC1 PIK3R1 LYN PPP2CA GRB10 FYN RAC1 PTPN1 PTPN11 PIK3CA LCK MAPK8 GRB2 SOS1 ARHA MAP2K2 RAF1 CYFIP2 NCKAP1 PRKCE MAP2K4 SRC ITGB3 IQGAP1 VAV2 AFDN RAP1A SPHK1 RAPGEF1 ITGAV S1PR1 PPP2R2B CRK PAG1 STAT5B CSK JUND PIK3R5 SFN NHERF1 JUN PIK3CD PIK3R3 PIK3R2 MAPK9 STAT3 PPP2R1A MAPK10 RAB5A PTEN MAP2K1 MAPK3 PLCG1 CBL ARHGAP35 YWHAQ HEL-S-1 NCK2 HRAS YWHAG YWHAZ DOK1 ARAP1 STAT1 USP6NL BRK1 RPS6KA3 PID_RHODOPSIN_PATHWAY%MSIGDB_C2%PID_RHODOPSIN_PATHWAY PID_RHODOPSIN_PATHWAY PDE6G RDH12 RHO RGS9BP SAG PDE6A RDH5 GNB1 LRAT GNB5 SLC24A1 GNGT1 CNGA1 GNAT1 GUCY2D GUCA1B GUCA1A GUCA1C GUCY2F RPE65 GRK1 BIOCARTA_RNA_PATHWAY%MSIGDB_C2%BIOCARTA_RNA_PATHWAY BIOCARTA_RNA_PATHWAY EIF2S2 EIF2S1 NFKBIA NFKB1 DNAJC3 CHUK RELA EIF2AK2 MAP3K14 BIOCARTA_NDKDYNAMIN_PATHWAY%MSIGDB_C2%BIOCARTA_NDKDYNAMIN_PATHWAY BIOCARTA_NDKDYNAMIN_PATHWAY NME2 PPP3CA SYNJ1 PPP3CC AP2A1 EPN1 AP2M1 CALM1 PICALM BIOCARTA_NO1_PATHWAY%MSIGDB_C2%BIOCARTA_NO1_PATHWAY BIOCARTA_NO1_PATHWAY PRKAR1B PRKAR1A KDR FLT4 PRKACG BDKRB2 CALM1 VEGFA CHRNA1 KNG1 CHRM1 RYR2 ACTA1 PDE2A PDE3B SLC7A1 PDE3A FLT1 TNNI1 PID_FAK_PATHWAY%MSIGDB_C2%PID_FAK_PATHWAY PID_FAK_PATHWAY ACTN1 DOCK1 GRB7 PXN WASL PAK1 ROCK2 ARHGEF7 RRAS MAPK1 NCK1 MAP2K4 BRAF SRC YES1 RAP1A ITGB5 PTPN21 RAPGEF1 ITGAV SH3GL1 ARHGAP26 TLN1 KLF8 CRK BMX CCND1 HEL114 JUN ASAP1 MAPK9 MAPK8IP3 PIK3R1 ELMO1 ACTA1 FYN RAC1 MAP2K1 ARHGEF28 PLCG1 PIK3CA ARHGAP35 MAPK8 MMP14 GRB2 SOS1 NCK2 ARHGEF11 ARHA ITGB1 GIT2 RAF1 PID_HIV_NEF_PATHWAY%MSIGDB_C2%PID_HIV_NEF_PATHWAY PID_HIV_NEF_PATHWAY TNF CYCS BIRC3 NFKBIA FAS CHUK RELA CRADD TRADD TRAF2 TNFRSF1A CASP2 RIPK1 TNFSF6 MAP3K14 NFKB1 CASP6 MAPK8 BCL2 CASP9 CASP8 MAP3K5 CASP3 BAG4 FADD DFFB DFFA TRAF1 APAF1 PID_TELOMERASE_PATHWAY%MSIGDB_C2%PID_TELOMERASE_PATHWAY PID_TELOMERASE_PATHWAY EGFR TNKS XRCC5 TERF1 MAPK1 IFNG RBBP4 BLM NBN PINX1 SMG6 PARP2 TINF2 DKC1 POT1 ATM TERF2IP WRN ACD PTGES3 IRF1 MRE11A ZNFX1 HUS1 HNRNPC CCND1 FOS RAD50 RAD1 NCL RAD9A JUN HDAC1 IFNAR2 SP1 MAX WT1 MYC SP3 NR2F2 HEL2 TERF2 SMG5 SIN3B TERT SIN3A SAP30 MAPK3 TGFB1 SAP18 IL2 RBBP7 NFKB1 MTOR RPS6KB1 MXD1 CDKN1B EGF HDAC2 UBE3A BIOCARTA_HCMV_PATHWAY%MSIGDB_C2%BIOCARTA_HCMV_PATHWAY BIOCARTA_HCMV_PATHWAY MAP2K6 MAP2K1 MAPK3 NFKB1 PIK3CA CREB1 SP1 MAPK1 RB1 MAP2K2 MAP2K3 MAPK14 PIK3R1 MAP3K1 RELA PID_RANBP2_PATHWAY%MSIGDB_C2%PID_RANBP2_PATHWAY PID_RANBP2_PATHWAY PIAS2 UBE2I SUMO1 RAN MDM2 HDAC1 RANBP2 PIAS1 BIOCARTA_PRION_PATHWAY%MSIGDB_C2%BIOCARTA_PRION_PATHWAY BIOCARTA_PRION_PATHWAY DNAJB1 DNAJB6 NFE2L2 APLP1 RPSA GFAP LAMA1 LAMB1 PRNP LAMC1 BCL2 HEL-S-89n BIOCARTA_TNFR2_PATHWAY%MSIGDB_C2%BIOCARTA_TNFR2_PATHWAY BIOCARTA_TNFR2_PATHWAY NFKB1 IKBKB NFKBIA MAP3K1 CHUK TNFAIP3 RELA TRAF2 TANK TRAF3 RIPK1 IKBKAP TRAF1 IKBKG TNFRSF1B MAP3K14 PID_CXCR4_PATHWAY%MSIGDB_C2%PID_CXCR4_PATHWAY PID_CXCR4_PATHWAY HGS PXN ADRBK1 MMP9 CXCL12 PAK1 CD3G CD3E HEL-S-15 CD3D MAPKAP1 MLST8 RICTOR BLK SRC YES1 RALB c-fgr CDC42 ITGAV CRK FOXO1 PAG1 STAT5B UBQLN1 RGS1 RHOB CSK VPS4B VPS4A SSH1 PTPN6 ARR3 PIK3R5 GNA13 GNG2 GNB1 PIK3CD ITGA4 PIK3R3 ITGA2 PIK3R2 ITGA1 STAT2 BAD STAT3 PIK3R1 ARRB2 PRKCZ LYN ITGA7 ITGA6 FYN RAC1 PTEN PTPN11 PDPK1 GNAZ MTOR GNAI3 PIK3CA GNAI1 LCK ITCH PTK2B PTPRC ARHA ITGB1 GNAO1 PLCB3 CXCR4 STAT1 PLCB1 HLA-DRA VAV1 PLCB2 LIMK1 BIOCARTA_LONGEVITY_PATHWAY%MSIGDB_C2%BIOCARTA_LONGEVITY_PATHWAY BIOCARTA_LONGEVITY_PATHWAY SHC1 PIK3R1 PIK3CA IGF1 GHR IGF1R GH1 FOXO3A HEL-S-44 HRAS BIOCARTA_ACTINY_PATHWAY%MSIGDB_C2%BIOCARTA_ACTINY_PATHWAY BIOCARTA_ACTINY_PATHWAY NCK1 HEL-S-276 WASL WASF2 NCKAP1 NTRK1 WASF1 ACTA1 ABI2 PIR WASF3 RAC1 BIOCARTA_ACETAMINOPHEN_PATHWAY%MSIGDB_C2%BIOCARTA_ACETAMINOPHEN_PATHWAY BIOCARTA_ACETAMINOPHEN_PATHWAY CYP1A2 CYP2E1 PTGS2 PTGS1 NR1I3 PID_PS1_PATHWAY%MSIGDB_C2%PID_PS1_PATHWAY PID_PS1_PATHWAY ADAM10 RBPJ NR1C2 JUN HDAC1 MAPK1 NOTCH1 MYC CSNK2A1 APC NEDD4 GSK3B MAP3K7 CREBBP MAPK3 PSEN1 AXIN1 FBXW11 NLK TLE5 DVL1 CTBP1 FZD1 FRAT1 MAP3K7IP1 CSNK1A1 HNF1A CTNNB1 CCND1 PSENEN FOS LRP6 WIF1 PPP2R5D DKK1 APH1B WNT1 DTX1 NKD1 DKK2 BIOCARTA_CXCR4_PATHWAY%MSIGDB_C2%BIOCARTA_CXCR4_PATHWAY BIOCARTA_CXCR4_PATHWAY MAP2K1 PRKCA MAPK3 NFKB1 CRK PLCG1 CXCL12 PIK3CA MAPK1 PTK2B HRAS PIK3R1 RELA CXCR4 RAF1 PRKCB PIK3C2G BIOCARTA_CB1R_PATHWAY%MSIGDB_C2%BIOCARTA_CB1R_PATHWAY BIOCARTA_CB1R_PATHWAY FAAH CNR2 BAAT PLD3 PLD2 CNR1 PID_CMYB_PATHWAY%MSIGDB_C2%PID_CMYB_PATHWAY PID_CMYB_PATHWAY CLTA MYOD1 BIRC3 NRAS CEBPA KRAS NCOR1 IQGAP1 CREBBP HES1 ADA CEBPB CDKN2A CEBPD ELANE NLK KITLG KIT LEF1 CCND1 SPI1 CCNB1 SLC25A3 PPP3CA LECT2 YEATS4 UBE2I RAG2 CD34 PAX5 SND1 ADORA2B COPA PIM1 TFEC SP1 PRTN3 MAD1L1 MYC HEL-S-11 H2AZ1 ZFHX3 GSTM1 ATP2B1 CBX4 LYZ CSF1R HIPK2 SKI MYF6 ETS2 SIN3A MYB MAP3K7 CDK6 ZFPM1 GATA1 CASP6 GATA3 BCL2 MAP3K7IP1 HRAS CDKN1A CDKN1B PTGS2 COL1A2 TRIM28 EP300 WNT1 MPO BIOCARTA_PRC2_PATHWAY%MSIGDB_C2%BIOCARTA_PRC2_PATHWAY BIOCARTA_PRC2_PATHWAY RBBP7 BMI1 HDAC1 RBBP4 CBX4 HDAC2 YY1 SUZ12 PHC1 EED COMMD3-BMI1 EZH1 EZH2 PID_S1P_S1P2_PATHWAY%MSIGDB_C2%PID_S1P_S1P2_PATHWAY PID_S1P_S1P2_PATHWAY GNA13 MAPK3 GNAZ GNAI3 GNAI1 GNA14 PAK1 JUN MAPK8 GNA15 GNA11 MAPK1 ARHA MAPK14 GNAO1 FOS IRS1 RAC1 S1PR2 BIOCARTA_INFLAM_PATHWAY%MSIGDB_C2%BIOCARTA_INFLAM_PATHWAY BIOCARTA_INFLAM_PATHWAY TNF IL10 IFNA1 IFNB1 IL15 IL13 IL7 IL4 IL3 IL6 IL5 PDGFA IFNG IL11 CSF1 CSF3 CSF2 TGFB1 IL2 HLA-DRB5 IL1A HLA-DRB4 HLA-DRA HLA-DRB3 HLA-DRB1 CXCL8 BIOCARTA_PLC_PATHWAY%MSIGDB_C2%BIOCARTA_PLC_PATHWAY BIOCARTA_PLC_PATHWAY PRKCA PIK3R1 PLCG1 PIK3CA PLCB1 VAV1 PRKCB BIOCARTA_IGF1R_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1R_PATHWAY BIOCARTA_IGF1R_PATHWAY MAP2K1 MAPK3 PRKAR1B PRKAR1A PRKACG PIK3CA IGF1R GRB2 MAPK1 SOS1 HRAS ADCY1 BAD SHC1 PIK3R1 RAF1 RPS6KA1 IRS1 PID_IL12_STAT4_PATHWAY%MSIGDB_C2%PID_IL12_STAT4_PATHWAY PID_IL12_STAT4_PATHWAY PPP3CA IL13 IL18 JUN CD3G CD3E CD3D IFNG MAPK9 PIAS2 STAT3 IL18RAP PPP3R1 TBX21 PRF1 CREBBP TGFB1 IL2 IL2RA MAPK8 IRF1 STAT4 IL18R1 FOS ETV5 CD80 HLA-DRA BIOCARTA_TERC_PATHWAY%MSIGDB_C2%BIOCARTA_TERC_PATHWAY BIOCARTA_TERC_PATHWAY RB1 SP3 NFYA NFYB SP1 NFYC BIOCARTA_SLRP_PATHWAY%MSIGDB_C2%BIOCARTA_SLRP_PATHWAY BIOCARTA_SLRP_PATHWAY DCN EPYC KERA PID_INTEGRIN_CS_PATHWAY%MSIGDB_C2%PID_INTEGRIN_CS_PATHWAY PID_INTEGRIN_CS_PATHWAY ITGAE ITGB8 ITGAV ITGB7 ITGB6 ITGB4 ITGA4 ITGA2 ITGA1 ITGB1 ITGB3 ITGA2B ITGA7 ITGAM ITGA6 ITGAX ITGB5 PID_SMAD2_3NUCLEAR_PATHWAY%MSIGDB_C2%PID_SMAD2_3NUCLEAR_PATHWAY PID_SMAD2_3NUCLEAR_PATHWAY IL10 MYOD1 IFNB1 KAT2B KAT2A RBL1 TFDP1 NR1i1 CREB1 IL5 IRF7 RBBP4 NCOR1 E2F4 E2F5 RUNX1 CREBBP ITGB5 CEBPB NR3C1 FOXO4 CDK2 FOXO1 NR2A1 FOS ATF3 CBFB NCOA1 JUN HDAC1 SP1 MAX RUNX2 MYC SP3 GSC SKI SIN3B SIN3A FOXO3A SKIL SAP30 SMAD2 SMAD4 SAP18 CITED1 RBBP7 MED15 SNIP1 TGIF1 TGIF2 LAMC1 FOXH1 RUNX3 CTBP1 GATA3 DLX1 FOXG1 CDKN2B DCP1A CDKN1A ATF2 HDAC2 TCF3 COL1A2 NKX2-5 EP300 MEF2C CDK4 BIOCARTA_P53HYPOXIA_PATHWAY%MSIGDB_C2%BIOCARTA_P53HYPOXIA_PATHWAY BIOCARTA_P53HYPOXIA_PATHWAY HIC1 FHL2 NQO1 ATM MAPK8 GADD45A RPA1 NFKBIB DNAJB1 CDKN1A BAX TAF1 MDM2 EP300 ABCB1 HIF1A BIOCARTA_BBCELL_PATHWAY%MSIGDB_C2%BIOCARTA_BBCELL_PATHWAY BIOCARTA_BBCELL_PATHWAY CD40 CD40LG FAS HLA-DRB5 HLA-DRB4 HLA-DRA HLA-DRB3 HLA-DRB1 TNFSF6 PID_HEDGEHOG_GLI_PATHWAY%MSIGDB_C2%PID_HEDGEHOG_GLI_PATHWAY PID_HEDGEHOG_GLI_PATHWAY GNG2 GNB1 HDAC1 SMO RBBP4 GSK3B ARRB2 SIN3B SIN3A CSNK1G3 CSNK1D CREBBP CSNK1G2 SAP30 CSNK1G1 MAP2K1 SAP18 RBBP7 GNAZ GNAI3 GNAI1 FBXW11 CSNK1E PIAS1 CSNK1A1 SHH IFT172 GLI3 PTCH1 KIF3A RAB23 GNAO1 SUFU HDAC2 SPOP MTSS1 FOXA2 PID_REG_GR_PATHWAY%MSIGDB_C2%PID_REG_GR_PATHWAY PID_REG_GR_PATHWAY IL13 EGR1 PPP5C IL4 CREB1 TSG101 IL6 IL5 MAPK1 IFNG SMARCD1 SMARCC1 SMARCC2 GSK3B BAX KRT5 SGK1 TBP MAPK11 CREBBP KRT14 CSF2 NR3C1 PRKACG POU2F1 SELE STAT5B IRF1 FOS NR1I3 POMC SPI1 NFATC1 SFN SUMO2 NCOA1 JUN HDAC1 PRL MAPK9 BGLAP MAPK14 SMARCA4 MAPK10 RELA MDM2 TBX21 MAPK3 IL2 NFKB1 GATA3 MAPK8 CDK5 CDKN1A CDK5R1 HDAC2 CSN2 KMT5B POU1F1 STAT1 EP300 FKBP4 FKBP5 CGA PCK2 CXCL8 AFP PBX1 BIOCARTA_G1_PATHWAY%MSIGDB_C2%BIOCARTA_G1_PATHWAY BIOCARTA_G1_PATHWAY SMAD4 SKP2 TGFB1 CDKN2A CDC2 DHFR TFDP1 CDK2 ATM HDAC1 CCNE1 CDKN2B RB1 CDKN1A CDKN1B CCND1 GSK3B ATR CDK6 CDK4 PID_RAC1_PATHWAY%MSIGDB_C2%PID_RAC1_PATHWAY PID_RAC1_PATHWAY NCF2 CYBB CYBA NOXA1 WASF2 CYFIP2 ARPC1B NCKAP1 ACTR3 ACTR2 PAK1 JUN PIP5K1A IQGAP3 HEL-S-15 HEL-S-47e MAPK9 MAP2K3 MAPK14 STAT3 MAP2K4 MAP3K1 ARPC4 ARPC5 IQGAP1 WASF1 BAIAP2 ARPC2 ARPC3 RAC1 CTNNA1 MAP2K6 PIP5K1C CRK ARHGAP5 MAPK8 MAP3K11 CTNNB1 ATF2 STM7 ABI2 PLCB2 BRK1 NCF1 LIMK1 BIOCARTA_KERATINOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_KERATINOCYTE_PATHWAY BIOCARTA_KERATINOCYTE_PATHWAY EGFR TNF PRKCA HOXA7 JUN SP1 MAPK1 PRKCE CEBPA MAP2K3 MAPK13 MAPK14 IKBKB MAP2K4 NFKBIA MAP3K1 FAS CHUK RELA ETS2 PPP2CA TRAF2 TNFRSF1A RIPK1 TNFSF6 MAP3K14 MAP2K6 MAP2K1 MAPK3 NFKB1 MAPK8 BCL2 HRAS PRKCH EGF FOS MAP3K5 PRKCQ RAF1 PRKCB TNFRSF1B BIOCARTA_AKAP13_PATHWAY%MSIGDB_C2%BIOCARTA_AKAP13_PATHWAY BIOCARTA_AKAP13_PATHWAY LPAR1 PRKACG LPAR2 LPAR3 PRKAG1 ARHA BIOCARTA_CARM_ER_PATHWAY%MSIGDB_C2%BIOCARTA_CARM_ER_PATHWAY BIOCARTA_CARM_ER_PATHWAY H3C15 NR0B1 MED1 HDAC1 SRA1 NCOR2 GRIP1 SPEN PHB2 PPARGC1A HDAC3 HDAC6 CCND1 CARM1 GTF2A1 HDAC5 HDAC2 BRCA1 TBP EP300 MEF2C CREBBP PELP1 PID_MAPK_TRK_PATHWAY%MSIGDB_C2%PID_MAPK_TRK_PATHWAY PID_MAPK_TRK_PATHWAY MAPK7 MAP2K5 MAP3K2 EGR1 NRAS CREB1 RPS6KA5 MAPK1 MAP2K3 MAPK14 BRAF KRAS TRPV1 RAP1A MAP2K6 MAP2K1 MAPK3 CDK5 HRAS CDK5R1 NTF3 FOS RIT1 RAF1 RIT2 RPS6KA1 MEF2C MAPKAPK2 BIOCARTA_NO2IL12_PATHWAY%MSIGDB_C2%BIOCARTA_NO2IL12_PATHWAY BIOCARTA_NO2IL12_PATHWAY TYK2 STAT4 CD2 CXCR3 CCR5 IL12RB1 NOS2 CD3G CD3E IFNG CD3D PID_LYSOPHOSPHOLIPID_PATHWAY%MSIGDB_C2%PID_LYSOPHOSPHOLIPID_PATHWAY PID_LYSOPHOSPHOLIPID_PATHWAY EGFR PXN MMP9 LPAR1 LPAR2 LPAR3 TIAM1 ADCY9 IL6 PRKCE ADCY3 ADCY1 NHERF2 LPAR4 ADCY8 ADCY6 SRC GSK3B CRK FOS GNA13 GNG2 GNB1 ARHGEF1 PLD2 JUN TRIP6 PIK3R1 NFKBIA RELA LYN PRKD1 RAC1 HBEGF NFKB1 GNAZ PLCG1 GNAI3 GNAI1 GNA14 GNA15 GNA11 MMP2 PTK2B HRAS ARHA GNAO1 PLCB3 CASP3 ADRA1B CXCL8 PID_P38_MKK3_6PATHWAY%MSIGDB_C2%PID_P38_MKK3_6PATHWAY PID_P38_MKK3_6PATHWAY MAP2K6 TAOK3 ATM TAOK1 GADD45A TAOK2 MAP3K7IP1 MAP2K3 MAP3K6 MAPK14 MAP3K1 MAP3K10 MAP3K5 TXN TRAF2 GADD45B MAPK11 MAP3K7 GADD45G TRAF6 RAC1 BIOCARTA_RACC_PATHWAY%MSIGDB_C2%BIOCARTA_RACC_PATHWAY BIOCARTA_RACC_PATHWAY TRPV4 ADCY1 KCNQ2 KCNQ3 GNAS KCNQ5 TRPC3 GUCY1A2 TRPC5 GUCY1B1 TRPC4 BIOCARTA_EIF2_PATHWAY%MSIGDB_C2%BIOCARTA_EIF2_PATHWAY BIOCARTA_EIF2_PATHWAY EIF2S2 EIF2S1 EIF2S3 EIF5 EIF2AK1 GSK3B EIF2AK4 EIF2B5 EIF2AK2 BIOCARTA_MITOCHONDRIA_PATHWAY%MSIGDB_C2%BIOCARTA_MITOCHONDRIA_PATHWAY BIOCARTA_MITOCHONDRIA_PATHWAY BIRC2 CASP6 BIRC3 BAK1 AIFM1 BCL2 DIABLO CASP9 CASP8 BAX BIK CASP3 DFFB DFFA APAF1 PID_IL2_1PATHWAY%MSIGDB_C2%PID_IL2_1PATHWAY PID_IL2_1PATHWAY NRAS MAPK1 PRKCE IFNG KRAS STAM2 SOCS2 MAPK11 CISH CDK2 STAT5B FOS PPP2R5D IRS1 IKZF3 PRKCB JUN SOCS3 SOCS1 MYC SYK MAPK9 MAPK14 SHC1 STAT3 PIK3R1 IL2RG FYN JAK3 JAK1 MAP2K1 PTPN11 GAB2 MAPK3 IL2 PIK3CA LCK IL2RA MAPK8 IL2RB BCL2 GRB2 SOS1 PTK2B HRAS ARHA MAP2K2 RAF1 STAT1 MAPKAPK2 PID_RHOA_PATHWAY%MSIGDB_C2%PID_RHOA_PATHWAY PID_RHOA_PATHWAY SH3GL2 ROCK1 ROCK2 PLD2 JUN PIP5K1A HEL-S-15 MAP2K3 LIMK2 MAP2K4 MAPK12 PRKCZ PARD6A ACTA1 SCAI HEL70 CDC42 RDX MRTFA CIT PTEN PKN2 MAP2K6 PIP5K1C MYL2 TLN1 EZR MAPK8 F2RL2 ARHA PKN1 CDKN1B ITGB1 ATF2 SLC9A3 HEL114 FOS STM7 CYR61 LIMK1 PID_BARD1_PATHWAY%MSIGDB_C2%PID_BARD1_PATHWAY PID_BARD1_PATHWAY UBE2L3 XRCC5 CCNE1 UBE2D3 CSTF1 RBBP8 BARD1 NBN EWSR1 RAD51 FANCL CDK2 ATM FANCA MRE11A FANCC FANCE PRKDC FANCG BRCA1 FANCF PCNA NPM1 RAD50 FANCD2 ATR TOPBP1 BIOCARTA_BARD1_PATHWAY%MSIGDB_C2%BIOCARTA_BARD1_PATHWAY BIOCARTA_BARD1_PATHWAY BARD1 FANCC FANCE FANCG BRCA1 FANCF FANCD2 FANCA BIOCARTA_NFAT_PATHWAY%MSIGDB_C2%BIOCARTA_NFAT_PATHWAY BIOCARTA_NFAT_PATHWAY NFATC2 NFATC1 F2 PPP3CA PPP3CC CAMK1 CAMK1G CALM1 MAPK1 MAPK14 PIK3R1 NFATC4 CAMK4 GSK3B ACTA1 CREBBP NPPA MAP2K1 CTF1 MAPK3 HEL-S-99n PRKAR1B PRKAR1A HAND2 HBEGF MYH2 HAND1 PRKACG RPS6KB1 IGF1 PIK3CA MAPK8 CSNK1A1 HRAS EDN1 GATA4 NFATC3 NKX2-5 RAF1 MEF2C FGF2 PID_SYNDECAN_2_PATHWAY%MSIGDB_C2%PID_SYNDECAN_2_PATHWAY PID_SYNDECAN_2_PATHWAY SDC2 TACI NF1 MAPK1 EPHB2 ITGA2 SRC BAX CSF2 MAPK3 TGFB1 CAV2 EZR TRAPPC4 MAPK8 MMP2 HRAS ARHA ITGB1 KNG1 LAMA1 LAMA3 CASP3 CASK SDCBP CXCL8 BIOCARTA_DNAFRAGMENT_PATHWAY%MSIGDB_C2%BIOCARTA_DNAFRAGMENT_PATHWAY BIOCARTA_DNAFRAGMENT_PATHWAY CASP3 DFFB TOP2A DFFA HMGB2 HMGB1 BIOCARTA_ION_PATHWAY%MSIGDB_C2%BIOCARTA_ION_PATHWAY BIOCARTA_ION_PATHWAY PRKCA PLCG1 P2RY2 PTK2B PRKCB BIOCARTA_TNFR1_PATHWAY%MSIGDB_C2%BIOCARTA_TNFR1_PATHWAY BIOCARTA_TNFR1_PATHWAY TNF MADD PAK1 JUN MAP2K4 MAP3K1 CRADD TRADD TRAF2 MAP3K7 TNFRSF1A CASP2 RIPK1 SPTAN1 MAPK8 RB1 LMNB2 PRKDC CASP8 CASP3 ARHGDIB BAG4 LMNA FADD DFFB DFFA PARP1 BIOCARTA_RANMS_PATHWAY%MSIGDB_C2%BIOCARTA_RANMS_PATHWAY BIOCARTA_RANMS_PATHWAY NUMA1 KPNA2 AURKA RAN KIF15 RANBP1 RCC1 HCTP4 PID_P75_NTR_PATHWAY%MSIGDB_C2%PID_P75_NTR_PATHWAY PID_P75_NTR_PATHWAY SQSTM1 CYCS BIRC2 BIRC3 NGFR NGF HEL-S-47e CHUK NTRK1 BCL2L11 TRAF6 IKBKG NSMCE3 OMG RTN4R BEX3 MAGEH1 ZNF274 BEX1 RTN4 NDN SORT1 PSENEN RHOB APH1B FURIN RIPK2 MAPK9 ADAM17 HEL2 BAD IKBKB SHC1 PIK3R1 PRKCZ IRAK1 MAPK10 RAC1 MYD88 PSEN1 CASP6 PIK3CA PRKCI APP MAPK8 ARHA DIABLO MAGED1 CASP9 NTF4 NTF3 CASP3 SMPD2 PLG MMP7 BDNF APAF1 MMP3 PID_ANTHRAX_PATHWAY%MSIGDB_C2%PID_ANTHRAX_PATHWAY PID_ANTHRAX_PATHWAY MAP2K6 MAP2K1 TNF MAPK3 VCAM1 IL18 MAPK1 MAP2K2 MAP2K3 PGR MAP2K4 ANTXR2 ANTXR1 DEFA1B NLRP1 IL1B PID_ECADHERIN_NASCENT_AJ_PATHWAY%MSIGDB_C2%PID_ECADHERIN_NASCENT_AJ_PATHWAY PID_ECADHERIN_NASCENT_AJ_PATHWAY WASF2 CYFIP2 CTNND1 NCKAP1 TIAM1 CSNK2A1 CSNK2A2 PIK3R1 SRC CSNK2B IQGAP1 VAV2 CDC42 RAC1 AFDN RAP1A CTNNA1 JUP ITGAE RAPGEF1 ARF6 ITGB7 PIP5K1C CRK PIK3CA TJP1 ARHA CTNNB1 CCND1 KLHL20 BIOCARTA_IL5_PATHWAY%MSIGDB_C2%BIOCARTA_IL5_PATHWAY BIOCARTA_IL5_PATHWAY IL5RA HLA-DRB5 CCL11 HLA-DRB4 IL4 HLA-DRA IL6 HLA-DRB3 CCR3 IL5 IL1B HLA-DRB1 PID_UPA_UPAR_PATHWAY%MSIGDB_C2%PID_UPA_UPAR_PATHWAY PID_UPA_UPAR_PATHWAY EGFR DOCK1 CTRC MMP9 GPLD1 SRC VTN ITGB3 ITGAM RAC1 ITGB5 ITGAV TGFB1 PLAUR CRK ELANE VLDLR ITGB1 FGA HGF FPR1 PLG KLK4 HEL-S-78p FPR2 PDGFD CTSG FPRL2 NCL MMP3 MMP12 BIOCARTA_IFNG_PATHWAY%MSIGDB_C2%BIOCARTA_IFNG_PATHWAY BIOCARTA_IFNG_PATHWAY IFNGR1 IFNGR2 STAT1 IFNG JAK1 PID_VEGFR1_2_PATHWAY%MSIGDB_C2%PID_VEGFR1_2_PATHWAY PID_VEGFR1_2_PATHWAY HGS ROCK1 PXN SH2D2A CAMKK2 MAPK1 ARF1 MAP2K3 NCK1 BRAF SRC ITGB3 IQGAP1 MAPK11 CDC42 FLT1 CTNNA1 MAP2K6 ITGAV KDR FBXW11 FES HEL114 PRKAB1 PTPN6 PRKCB HSP90AB1 PRKCA MYOF VEGFA MAPK14 NEDD4 PIK3R1 VTN PRKAG1 GRB10 FYN MAP2K1 PTPN11 SHB MAPK3 PDPK1 PLCG1 PIK3CA CBL GRB2 PTK2B NCK2 ARHA MAP2K2 PRKAA1 CTNNB1 PRKAA2 RAF1 MAPKAPK2 PID_ARF6_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_ARF6_DOWNSTREAM_PATHWAY PID_ARF6_DOWNSTREAM_PATHWAY ARF6 MAPK3 RAB11FIP3 PLAUR KALRN RAB11A PLD2 TIAM1 PIP5K1A MAPK1 ARHA ARF1 RAC1 BIOCARTA_ERBB3_PATHWAY%MSIGDB_C2%BIOCARTA_ERBB3_PATHWAY BIOCARTA_ERBB3_PATHWAY EGFR EGF UBE2D1 ERBB3 NRG1 BIOCARTA_MELANOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_MELANOCYTE_PATHWAY BIOCARTA_MELANOCYTE_PATHWAY KITLG CREB1 KIT EP300 RPS6KA1 BCL2 BIOCARTA_EGFR_SMRTE_PATHWAY%MSIGDB_C2%BIOCARTA_EGFR_SMRTE_PATHWAY BIOCARTA_EGFR_SMRTE_PATHWAY EGFR MAP2K1 MAPK14 EGF THRA MAP3K1 ZBTB16 NR1A2 NCOR2 RXRA RARA BIOCARTA_GSK3_PATHWAY%MSIGDB_C2%BIOCARTA_GSK3_PATHWAY BIOCARTA_GSK3_PATHWAY PDPK1 NFKB1 AXIN1 LBP PIK3CA DVL1 FZD1 LEF1 EIF2AK2 APC CTNNB1 CCND1 PIK3R1 GSK3B RELA PPP2CA GJA1 WNT1 MYD88 BIOCARTA_PITX2_PATHWAY%MSIGDB_C2%BIOCARTA_PITX2_PATHWAY BIOCARTA_PITX2_PATHWAY PITX2 AXIN1 LDB1 DVL1 FZD1 MED1 HDAC1 LEF1 APC CTNNB1 TRRAP GSK3B EP300 WNT1 CREBBP KAT5 BIOCARTA_IL17_PATHWAY%MSIGDB_C2%BIOCARTA_IL17_PATHWAY BIOCARTA_IL17_PATHWAY CD8A CD58 CD34 KITLG IL3 IL6 CD3G CD3E CD3D IL17A CD2 CSF3 CXCL8 BIOCARTA_FMLP_PATHWAY%MSIGDB_C2%BIOCARTA_FMLP_PATHWAY BIOCARTA_FMLP_PATHWAY NCF2 NFATC2 NFATC1 PPP3CA PPP3CC CAMK1 CAMK1G CALM1 PAK1 MAPK1 MAP2K3 MAPK14 NFATC4 NFKBIA MAP3K1 RELA RAC1 MAP2K6 MAP2K1 MAPK3 NFKB1 GNA15 HRAS MAP2K2 NFATC3 FPR1 RAF1 PLCB1 NCF1 PIK3C2G BIOCARTA_PS1_PATHWAY%MSIGDB_C2%BIOCARTA_PS1_PATHWAY BIOCARTA_PS1_PATHWAY PSEN1 RBPJ AXIN1 DVL1 FZD1 BTRC NOTCH1 ADAM17 APC HNF1A CTNNB1 GSK3B WNT1 BIOCARTA_EOSINOPHILS_PATHWAY%MSIGDB_C2%BIOCARTA_EOSINOPHILS_PATHWAY BIOCARTA_EOSINOPHILS_PATHWAY HLA-DRB5 CCL11 HLA-DRB4 IL3 HLA-DRA HLA-DRB3 CCR3 IL5 HLA-DRB1 CSF2 CCL5 PID_VEGF_VEGFR_PATHWAY%MSIGDB_C2%PID_VEGF_VEGFR_PATHWAY PID_VEGF_VEGFR_PATHWAY KDR FLT4 VEGFC VEGFD NRP1 VEGFA NRP2 VEGFB FLT1 BIOCARTA_VOBESITY_PATHWAY%MSIGDB_C2%BIOCARTA_VOBESITY_PATHWAY BIOCARTA_VOBESITY_PATHWAY TNF NR3C1 HSD11B1 RETN RXRA LPL PPARG BIOCARTA_MPR_PATHWAY%MSIGDB_C2%BIOCARTA_MPR_PATHWAY BIOCARTA_MPR_PATHWAY PIN1 CCNB1 MAPK3 PRKAR1B CDC2 PRKAR1A PRKACG CAP1 PAQR7 PAQR5 MAPK1 HRAS ADCY1 PGR MYT1 ACTA1 RPS6KA1 BIOCARTA_RAC1_PATHWAY%MSIGDB_C2%BIOCARTA_RAC1_PATHWAY BIOCARTA_RAC1_PATHWAY PDGFRA RALBP1 NCF2 TRIO MYL2 RPS6KB1 PIK3CA PAK1 CDK5 CDK5R1 PIK3R1 MAP3K1 PPP1R12B WASF1 VAV1 RAC1 LIMK1 CHN1 PID_SYNDECAN_1_PATHWAY%MSIGDB_C2%PID_SYNDECAN_1_PATHWAY PID_SYNDECAN_1_PATHWAY COL4A1 MMP9 COL4A4 COL4A3 COL4A6 COL4A5 MAPK1 hEMMPRIN HPSE PPIB COL1A1 SDC1 MAPK3 TGFB1 COL17A1 COL16A1 LAMA5 COL14A1 COL12A1 COL10A1 COL2A1 COL6A1 COL8A2 COL8A1 COL13A1 COL11A2 COL5A2 COL9A1 COL9A3 COL9A2 MET COL3A1 HGF COL1A2 CASK SDCBP MMP7 CCL5 BIOCARTA_D4GDI_PATHWAY%MSIGDB_C2%BIOCARTA_D4GDI_PATHWAY BIOCARTA_D4GDI_PATHWAY CASP9 CASP10 CASP8 CASP3 ARHGDIB ARHGAP5 JUN PRF1 PARP1 APAF1 PID_IL6_7_PATHWAY%MSIGDB_C2%PID_IL6_7_PATHWAY PID_IL6_7_PATHWAY LBP JUN SOCS3 IL6 MYC TNFSF11 LMO4 CRP HEL-S-125m MAPK14 A2M STAT3 PIK3R1 MAP2K4 PTPRE MCL1 MAPK11 RAC1 JAK1 MAP2K6 PTPN11 CEBPB GAB2 CEBPD PIK3CA FOXO1 GRB2 IL6ST TIMP1 IL6R PIAS1 SOS1 IRF1 BCL2L1 TYK2 FOS JUNB STAT1 VAV1 BIOCARTA_REELIN_PATHWAY%MSIGDB_C2%BIOCARTA_REELIN_PATHWAY BIOCARTA_REELIN_PATHWAY CDK5R1 VLDLR LRP8 DAB1 FYN RELN CDK5 PID_ATF2_PATHWAY%MSIGDB_C2%PID_ATF2_PATHWAY PID_ATF2_PATHWAY CCNA2 CREB1 IL6 TH MAPK1 IFNG DUSP8 MAPK11 DUSP10 KAT5 RUVBL2 HES1 POU2F1 SELE CCND1 FOS JUNB JUND ATF3 PRKCA ARG1 CBFB NOS2 NF1 JUN INS SOCS3 GADD45A PPARGC1A MAPK9 MAPK14 HRK ACHE CSRP2 JDP2 MACROH2A1 COL24A1 HBG2 PDGFRA MAPK3 DUSP5 MAPK8 BCL2 MMP2 SERPINB5 BCL2L1 RB1 ATF2 BRCA1 EP300 DDIT3 CXCL8 CDK4 IL23A BIOCARTA_AKAPCENTROSOME_PATHWAY%MSIGDB_C2%BIOCARTA_AKAPCENTROSOME_PATHWAY BIOCARTA_AKAPCENTROSOME_PATHWAY PKN1 CDC2 MAP2 PRKACG PPP2CA PRKAG1 NUP85 AKAP9 PRKCE PCNT ARHA PID_NFAT_3PATHWAY%MSIGDB_C2%PID_NFAT_3PATHWAY PID_NFAT_3PATHWAY NFATC2 PRKCA NFATC1 AKAP5 CABIN1 PPP3CA CHP1 SFN RAN MEF2D NUP214 PIM1 PRKCE CSNK2A1 RCAN1 MAPK9 MAP3K8 KPNA2 HEL2 BAD MAPK14 CAMK4 MAP3K1 GSK3B PRKCZ PPP3R1 CREBBP MAPK3 MAPK8 FKBP1A BCL2 YWHAQ HEL-S-1 CSNK1A1 BCL2L1 YWHAG PRKCH NFATC3 YWHAZ CASP3 PRKCQ EP300 PRKCB BIOCARTA_ACH_PATHWAY%MSIGDB_C2%BIOCARTA_ACH_PATHWAY BIOCARTA_ACH_PATHWAY CHRNG MUSK BAD RAPSN PIK3R1 PIK3CA TERT FOXO3A TNFSF6 PTK2B CHRNB1 PID_NOTCH_PATHWAY%MSIGDB_C2%PID_NOTCH_PATHWAY PID_NOTCH_PATHWAY ADAM10 NUMB RBPJ KDM1A MAML2 MAML1 RAB11A ADAM12 IL4 HDAC1 NCOR2 SPEN NOTCH1 MYC RBBP8 NCOR1 FBXW7 SKP2 NOTCH3 MYCBP PSEN1 DLL3 DLL4 DNER CBL JAG2 MIB1 CTBP1 GATA3 MFAP5 MFAP2 CNTN1 ITCH LNX1 ENO1 CDKN1A CCND1 PSENEN YY1 SKP1 EP300 APH1B NOTCH2 DTX1 FURIN PID_BMP_PATHWAY%MSIGDB_C2%PID_BMP_PATHWAY PID_BMP_PATHWAY BMP4 BMP2 BMPR1A NUP214 MAPK1 SMAD9 PPP1R15A GSK3B SKI MAP3K7 SMAD4 SMURF2 SMURF1 MAP3K7IP1 CHRDL1 ZFYVE16 SOSTDC1 CER1 BAMBI CTDSP1 AHSG CTDSP2 FST CTDSPL HFE2 BMPR2 RGMB BMP6 RGMA DKFZp781O1323 GREM1 SMAD1 NOG BMP7 PID_CD8_TCR_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_CD8_TCR_DOWNSTREAM_PATHWAY PID_CD8_TCR_DOWNSTREAM_PATHWAY IFNA17 TNF TNFRSF18 IFNA10 IFNA1 IFNA21 EGR4 CD8A IF1AA9 EGR1 NRAS CD3G CD3E MAPK1 CD3D PRKCE IFNG BRAF KRAS TNFRSF9 CD8B1 STAT4 FOS NFATC3 JUNB PRKCB NFATC2 PRKCA NFATC1 PPP3CA JUN IFNAR2 IFNAR1 MAPK9 IL2RG PPP3R1 PRF1 HLA-A B2M TNFSF6 MAP2K1 FOSL1 MAPK3 IL2 IL2RA MAPK8 IL2RB HRAS MAP2K2 IFNA4 PRKCQ IFNA7 RAF1 IFNA6 IFNA2 IFNA8 TNFRSF4 IFNA14 IFNA16 BIOCARTA_EXTRINSIC_PATHWAY%MSIGDB_C2%BIOCARTA_EXTRINSIC_PATHWAY BIOCARTA_EXTRINSIC_PATHWAY PROS1 F7 FGA F2 F10 F3 SERPINC1 F5 TFPI HEL-S-78p PROC F2R PID_PTP1B_PATHWAY%MSIGDB_C2%PID_PTP1B_PATHWAY PID_PTP1B_PATHWAY EGFR YBX1 NOX4 INS SOCS3 PRL LEP PRLR SHC1 STAT3 PIK3R1 BLK CSF1R SRC CSF1 ITGB3 YES1 LYN LAT CDH2 LEPR c-fgr FYN PTPN1 FER INSR CRK PIK3CA LCK STAT5B GRB2 TRPV6 ARHA TYK2 EGF CSK CSN2 DOK1 ITGA2B TXN SPRY2 IRS1 FCGR2A BIOCARTA_STEM_PATHWAY%MSIGDB_C2%BIOCARTA_STEM_PATHWAY BIOCARTA_STEM_PATHWAY IL2 CD8A IL7 EPO IL4 IL3 IL6 IL5 IL9 IL11 CSF1 CSF3 CXCL8 CSF2 PID_NFAT_TFPATHWAY%MSIGDB_C2%PID_NFAT_TFPATHWAY PID_NFAT_TFPATHWAY NFATC2 TNF NFATC1 EGR4 BATF3 IRF4 EGR1 IL4 DGKA JUN IL3 SLC3A2 IKZF1 IL5 PTPRK GBP3 IFNG PPARG EGR2 RNF128 CD40LG TBX21 FOXP3 PTPN1 TNFSF6 CSF2 CTLA4 FOSL1 IL2 POU2F1 IL2RA GATA3 ITCH PTGS2 NFATC3 FOS CASP3 JUNB PRKCQ CXCL8 CDK4 BIOCARTA_MITR_PATHWAY%MSIGDB_C2%BIOCARTA_MITR_PATHWAY BIOCARTA_MITR_PATHWAY HDAC9 MYOD1 CAMK1 CAMK1G PID_TCPTP_PATHWAY%MSIGDB_C2%PID_TCPTP_PATHWAY PID_TCPTP_PATHWAY EGFR VEGFA INS PIK3CD EIF2AK2 PIK3R3 PIK3R2 LMAN1 KPNA2 ITGA1 SHC1 STAT3 PIK3R1 CSF1R SRC CSF1 CREBBP JAK3 PTPN1 JAK1 INSR KDR PIK3CA STAT5B RAB4A GRB2 PIAS1 SOS1 ITGB1 EGF MET HGF STAT1 ATR BIOCARTA_PELP1_PATHWAY%MSIGDB_C2%BIOCARTA_PELP1_PATHWAY BIOCARTA_PELP1_PATHWAY MAPK3 EP300 CREBBP MAPK1 PELP1 BIOCARTA_BLYMPHOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_BLYMPHOCYTE_PATHWAY BIOCARTA_BLYMPHOCYTE_PATHWAY CD40 CR2 CR1 HLA-DRB5 HLA-DRB4 CD80 HLA-DRA HLA-DRB3 FCGR2B HLA-DRB1 PTPRC BIOCARTA_PDZS_PATHWAY%MSIGDB_C2%BIOCARTA_PDZS_PATHWAY BIOCARTA_PDZS_PATHWAY DLG4 PCLO DLG2 GRIN1 GUK1 NRXN3 NCAM1 SPTAN1 CASK ADD1 ACTA1 SPTBN1 BIOCARTA_MAL_PATHWAY%MSIGDB_C2%BIOCARTA_MAL_PATHWAY BIOCARTA_MAL_PATHWAY MAP2K1 ROCK1 MAPK3 MAPK8 MAPK1 ARHA HRAS MAP2K2 HNF1A MAP4K2 MAP3K1 ACTA1 MAL RAF1 CDC42 RAC1 LIMK1 BIOCARTA_IL22BP_PATHWAY%MSIGDB_C2%BIOCARTA_IL22BP_PATHWAY BIOCARTA_IL22BP_PATHWAY TYK2 STAT3 STAT1 SOCS3 STAT5B JAK3 JAK1 BIOCARTA_CIRCADIAN_PATHWAY%MSIGDB_C2%BIOCARTA_CIRCADIAN_PATHWAY BIOCARTA_CIRCADIAN_PATHWAY CRY2 CRY1 CSNK1E PER1 BIOCARTA_LYM_PATHWAY%MSIGDB_C2%BIOCARTA_LYM_PATHWAY BIOCARTA_LYM_PATHWAY ITGB1 IL1A VCAM1 CD34 MADCAM1 SELL PECAM1 ITGA4 ICAM2 CXCL8 PID_EPO_PATHWAY%MSIGDB_C2%PID_EPO_PATHWAY PID_EPO_PATHWAY SOCS3 MAPK14 SHC1 PIK3R1 LYN BTK SH2B3 VAV2 PLCG2 TEC RAP1A RAPGEF1 PTPN11 CRKL EPOR NFKB1 PLCG1 CBL EPO MAPK8 BCL2 STAT5B GRB2 SOS1 HRAS TRPC6 BCL2L1 STAT1 PTPN6 BIOCARTA_SHH_PATHWAY%MSIGDB_C2%BIOCARTA_SHH_PATHWAY BIOCARTA_SHH_PATHWAY PTCH1 GLI3 PRKAR1B PRKAR1A SUFU GSK3B PRKACG DYRK1A SMO DYRK1B SHH PID_P53_REGULATION_PATHWAY%MSIGDB_C2%PID_P53_REGULATION_PATHWAY PID_P53_REGULATION_PATHWAY CCNA2 KAT2B RFWD2 CCNG1 GSK3B CSNK1G3 CSNK1D KAT5 CSNK1G2 CREBBP CHEK1 CSNK1G1 RPL5 DYRK2 PIN1 SETD8 SKP2 SETD7 CDKN2A TP53AIP1 RASSF1 PPP1R13L KAT8 RPL23 FBXO11 CDK2 PPM1D ATM PTPA SMYD2 CSNK1E E4F1 MDM4 CSNK1A1 NEDD8 CHEK2 ATR UBE2D1 MAPK9 MAPK14 RPL11 HIPK2 PPP2CA MDM2 HUWE1 MAPK8 YY1 TRIM28 EP300 RCHY1 BIOCARTA_INSULIN_PATHWAY%MSIGDB_C2%BIOCARTA_INSULIN_PATHWAY BIOCARTA_INSULIN_PATHWAY MAP2K1 PTPN11 MAPK3 INSR SLC2A4 PIK3CA JUN MAPK8 GRB2 SOS1 CSNK2A1 HRAS SHC1 PIK3R1 FOS RAF1 IRS1 PID_FAS_PATHWAY%MSIGDB_C2%PID_FAS_PATHWAY PID_FAS_PATHWAY BIRC2 CLTC BIRC3 PIK3CD PIK3R3 PIK3R2 MAPK9 SYK MAPK14 IKBKB PIK3R1 SRC MAP3K1 FAS CHUK MAPK10 BTK SMPD1 MAPK11 RIPK1 IKBKG TNFSF6 MAP2K6 CASP10 PDPK1 EZR PIK3CA MAPK8 FAIM2 CASP8 CASP3 FADD RFC1 BIOCARTA_ERAD_PATHWAY%MSIGDB_C2%BIOCARTA_ERAD_PATHWAY BIOCARTA_ERAD_PATHWAY RBX1 UBE2I UBA2 SAE1 EDEM1 FBXO2 SEC61A1 GANAB MAN2A2 CANX MAN1A2 GCS1 UGGT1 SKP1 MAN1A1 MAN2C1 BIOCARTA_EIF_PATHWAY%MSIGDB_C2%BIOCARTA_EIF_PATHWAY BIOCARTA_EIF_PATHWAY EIF2S2 EIF4A2 SUI1 EIF2S1 AAG1 EIF2S3 EIF4A1 EIF4G1 EIF3A EEF2K EIF5 EEF2 EIF6 EIF4E EIF1AX PID_BCR_5PATHWAY%MSIGDB_C2%PID_BCR_5PATHWAY PID_BCR_5PATHWAY MAPK1 DAPP1 BLNK MAP3K1 CHUK BTK POU2F2 VAV2 PLCG2 TRAF6 IKBKG PAG1 CARD11 FOS CSK CD19 SH3BP5 CD72 IBTK CD22 PTPN6 NFATC1 PPP3CA PPP3CC JUN CSNK2A1 SYK BCL10 MAPK14 IKBKB SHC1 PIK3R1 NFKBIA RELA LYN MAP3K7 CAMK2G RAC1 PTEN CD79B CD79A MAP2K1 MAPK3 PDPK1 NFKB1 PIK3CA MAPK8 GRB2 SOS1 HRAS PTPRC NFKBIB DOK1 BCL2A1 RAF1 FCGR2B MAP4K1 PID_ER_NONGENOMIC_PATHWAY%MSIGDB_C2%PID_ER_NONGENOMIC_PATHWAY PID_ER_NONGENOMIC_PATHWAY GNA13 GNG2 MMP9 GNB1 ROCK2 NRAS GNAL SHC1 PIK3R1 SRC KRAS HEL70 NR3A2 MAPK11 PELP1 HBEGF GNAZ GNAI3 GNAI1 PIK3CA IGF1R GNA14 GNA15 GNA11 GRB2 SOS1 MMP2 HRAS ARHA GNAO1 PLCB3 PLCB1 PLCB2 STRN BIOCARTA_WNT_LRP6_PATHWAY%MSIGDB_C2%BIOCARTA_WNT_LRP6_PATHWAY BIOCARTA_WNT_LRP6_PATHWAY FZD1 DKK1 WNT8A WNT8B DKK2 BIOCARTA_INTRINSIC_PATHWAY%MSIGDB_C2%BIOCARTA_INTRINSIC_PATHWAY BIOCARTA_INTRINSIC_PATHWAY F8 PROS1 SERPING1 COL4A2 KLKB1 F2 COL4A1 COL4A4 COL4A3 SERPINC1 F5 COL4A6 COL4A5 F9 F11 F2R FGA KNG1 F10 HEL-S-78p PROC PID_INTEGRIN5_PATHWAY%MSIGDB_C2%PID_INTEGRIN5_PATHWAY PID_INTEGRIN5_PATHWAY ITGB8 ITGAV ITGB7 ITGB6 PLAUR VCAM1 TGFBR1 ITGA4 VTN EDIL3 SDC1 MADCAM1 FBN1 CYR61 ITGB5 BIOCARTA_TID_PATHWAY%MSIGDB_C2%BIOCARTA_TID_PATHWAY BIOCARTA_TID_PATHWAY TNF USH1C LIN7A NFKB1 IFNGR1 TAX1BP3 IFNGR2 IFNG WT1 RB1 IKBKB NFKBIA RELA TNFRSF1A TNFRSF1B BIOCARTA_CELL2CELL_PATHWAY%MSIGDB_C2%BIOCARTA_CELL2CELL_PATHWAY BIOCARTA_CELL2CELL_PATHWAY ACTN1 CTNNB1 ACTN2 HEL114 LRRTM2 CSK CTNNA3 CTNNA2 PECAM1 CTNNA1 BIOCARTA_FBW7_PATHWAY%MSIGDB_C2%BIOCARTA_FBW7_PATHWAY BIOCARTA_FBW7_PATHWAY RB1 SKP1 TFDP1 FBXW7 CDK2 CDC34 CCNE1 BIOCARTA_FLUMAZENIL_PATHWAY%MSIGDB_C2%BIOCARTA_FLUMAZENIL_PATHWAY BIOCARTA_FLUMAZENIL_PATHWAY GABRA3 GPX1 GABRA2 GABRA6 GABRA5 PRKCE GABRA4 HEL-S-44 PID_S1P_S1P1_PATHWAY%MSIGDB_C2%PID_S1P_S1P1_PATHWAY PID_S1P_S1P1_PATHWAY SPHK1 S1PR1 ITGAV MAPK3 GNAZ KDR PLCG1 GNAI3 GNAI1 VEGFA MAPK1 ARHA GNAO1 PTGS2 ITGB3 ABCC1 PLCB2 RAC1 BIOCARTA_RAN_PATHWAY%MSIGDB_C2%BIOCARTA_RAN_PATHWAY BIOCARTA_RAN_PATHWAY RAN RANBP2 RANBP1 RCC1 BIOCARTA_SKP2E2F_PATHWAY%MSIGDB_C2%BIOCARTA_SKP2E2F_PATHWAY BIOCARTA_SKP2E2F_PATHWAY RB1 SKP2 SKP1 TFDP1 CDK2 CDC34 CCNE1 BIOCARTA_BCR_PATHWAY%MSIGDB_C2%BIOCARTA_BCR_PATHWAY BIOCARTA_BCR_PATHWAY NFATC2 PRKCA NFATC1 PPP3CA PPP3CC CALM1 JUN SYK MAPK14 SHC1 NFATC4 MAP3K1 LYN BTK RAC1 CD79B CD79A MAP2K1 MAPK3 PLCG1 MAPK8 GRB2 SOS1 HRAS NFATC3 FOS RAF1 VAV1 PRKCB BIOCARTA_HBX_PATHWAY%MSIGDB_C2%BIOCARTA_HBX_PATHWAY BIOCARTA_HBX_PATHWAY SHC1 LAMTOR5 CREB1 GRB2 SOS1 PTK2B HRAS PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY NOS2 EIF4EBP1 GDI1 JUN CREB1 USF1 KRT19 RPS6KA5 PPARGC1A CSNK2A1 CSNK2A2 ATF1 MAPK14 CSNK2B RAB5A MAPK11 EIF4E CEBPB ATF2 PTGS2 MAPKAPK3 HEL-S-102 DDIT3 MEF2C MAPKAPK2 MAPKAPK5 RPS6KA4 BIOCARTA_AGR_PATHWAY%MSIGDB_C2%BIOCARTA_AGR_PATHWAY BIOCARTA_AGR_PATHWAY EGFR PAK1 JUN CHRNA1 SP1 DAG1 MAPK1 DMD AGRN PAK4 ACTA1 CDC42 NRG1 RAC1 NRG2 MUSK NRG3 MAPK3 RAPSN LAMA4 DVL1 MAPK8 ITGB1 CHRM1 GIT2 LAMA3 BIOCARTA_LAIR_PATHWAY%MSIGDB_C2%BIOCARTA_LAIR_PATHWAY BIOCARTA_LAIR_PATHWAY TNF C6 C7 VCAM1 IL6 ITGA4 ITGB1 KNG1 HEL-S-62p IL1A SELP SELPLG CXCL8 BIOCARTA_TUBBY_PATHWAY%MSIGDB_C2%BIOCARTA_TUBBY_PATHWAY BIOCARTA_TUBBY_PATHWAY TUB CHRM1 PLCB1 PID_RET_PATHWAY%MSIGDB_C2%PID_RET_PATHWAY PID_RET_PATHWAY GRB7 PRKCA PXN GDNF JUN CREB1 MAPK1 PDLIM7 NCK1 DOK4 SHC1 DOK5 PIK3R1 DOK6 SRC SHANK3 GRB10 RAC1 RAP1A PTPN11 MAPK3 CRK PIK3CA MAPK8 GRB2 SOS1 HRAS FRS2 ARHA DOK1 RET IRS1 BIOCARTA_GPCR_PATHWAY%MSIGDB_C2%BIOCARTA_GPCR_PATHWAY BIOCARTA_GPCR_PATHWAY NFATC2 MAP2K1 PRKCA NFATC1 MAPK3 PRKAR1B PPP3CA PRKAR1A PPP3CC PLCG1 PRKACG CALM1 JUN CREB1 HRAS ADCY1 NFATC4 NFATC3 FOS RAF1 PRKCB RPS6KA3 PID_INTEGRIN_A4B1_PATHWAY%MSIGDB_C2%PID_INTEGRIN_A4B1_PATHWAY PID_INTEGRIN_A4B1_PATHWAY DOCK1 PXN SPP1 VCAM1 ITGA4 SRC IGSF8 CD81 THBS2 ADAM28 AMICA1 RAC1 ARF6 JAM2 PRKAR1B TLN1 PRKAR1A CRK MYH2 CD14 PTK2B ITGB1 YWHAZ THBS1 MDK BIOCARTA_CHEMICAL_PATHWAY%MSIGDB_C2%BIOCARTA_CHEMICAL_PATHWAY BIOCARTA_CHEMICAL_PATHWAY PRKCA EIF2S1 TLN1 CASP6 ATM BCL2 BAD CASP9 BAX CASP3 STAT1 PARP1 APAF1 PRKCB BIOCARTA_SPPA_PATHWAY%MSIGDB_C2%BIOCARTA_SPPA_PATHWAY BIOCARTA_SPPA_PATHWAY MAP2K1 PRKCA MAPK3 F2 MAPK1 F2RL3 F2R HRAS SYK ITGB1 PTGS1 RAF1 PLCB1 PRKCB BIOCARTA_SRCRPTP_PATHWAY%MSIGDB_C2%BIOCARTA_SRCRPTP_PATHWAY BIOCARTA_SRCRPTP_PATHWAY PRKCA CCNB1 CDC2 CSK CDC25B VPS16 GRB2 PRKCB PID_HIF2PATHWAY%MSIGDB_C2%PID_HIF2PATHWAY PID_HIF2PATHWAY SIRT1 EFNA1 EGLN1 EGLN3 VEGFA SP1 APEX1 SLC11A2 CREBBP POU5F1 FLT1 ADORA2A EIF3E FXN EGLN2 KDR VHL ELOC HIF1AN EPO CITED2 MMP14 HEL-S-68p ABCG2 EP300 BHLHB2 TWIST1 PID_EPHRINB_REV_PATHWAY%MSIGDB_C2%PID_EPHRINB_REV_PATHWAY PID_EPHRINB_REV_PATHWAY EFNB2 EFNB1 TIAM1 EPHB2 EPHB1 EPHB4 PIK3R1 MAP2K4 BLK SRC ITGB3 YES1 LYN c-fgr FYN MAP3K7 RAC1 PIK3CA LCK MAPK8 PTPN13 NCK2 FGA ITGA2B CXCR4 HEL-S-78p PID_CD40_PATHWAY%MSIGDB_C2%PID_CD40_PATHWAY PID_CD40_PATHWAY BIRC2 BIRC3 IL4 JUN MYC MAPK9 CD40 MAPK14 CD40LG MAP2K4 NFKBIA MAP3K1 MAPK10 RELA TRAF2 TRAF3 MAPK11 TRAF6 JAK3 MAP3K14 C4BPA FCAMR NFKB1 MAPK8 BCL2L1 TNFAIP3 TRAF1 PID_MTOR_4PATHWAY%MSIGDB_C2%PID_MTOR_4PATHWAY PID_MTOR_4PATHWAY AKT1S1 PXN CYCS EIF4EBP1 NRAS CCNE1 MAPK1 MAPKAP1 PML RB1CC1 MLST8 RICTOR BRAF KRAS SGK1 FBXW11 CDK2 EEF2K EEF2 TSC2 RPS6KA1 IRS1 DDIT4 PRKCA SFN BNIP3 EIF4A1 PLD2 PPARGC1A HEL2 IKBKB TSC1 RHEB RAC1 EIF4E MAP2K1 MAPK3 PRR5 PDPK1 RRAGA RRAGB MTOR RRAGD RPS6KB1 ULK2 ULK1 RRN3 POLDIP3 EIF4B YWHAQ HEL-S-1 HRAS ARHA MAP2K2 YWHAG YWHAZ YY1 RAF1 RPTOR DEPTOR BIOCARTA_PPARA_PATHWAY%MSIGDB_C2%BIOCARTA_PPARA_PATHWAY BIOCARTA_PPARA_PATHWAY TNF PRKCA NOS2 NR0B2 NR1H3 NCOA1 JUN SRA1 MED1 NCOR2 RXRA SP1 LPL MAPK1 PDGFA MYC PPARGC1A PIK3R1 NFKBIA NCOR1 RELA ME1 CREBBP MAPK3 PRKAR1B PRKAR1A NR1C1 PRKACG PIK3CA CITED2 HSD17B4 STAT5B MRPL11 DUT APOA2 RB1 FABP1 ACOX1 EHHADH PTGS2 EP300 PRKCB BIOCARTA_ALTERNATIVE_PATHWAY%MSIGDB_C2%BIOCARTA_ALTERNATIVE_PATHWAY BIOCARTA_ALTERNATIVE_PATHWAY C8A CFP C6 C7 HEL-S-62p C9 CFD PID_P73PATHWAY%MSIGDB_C2%PID_P73PATHWAY PID_P73PATHWAY SIRT1 CCNA2 BAK1 CCNE2 GDF15 PML FAS BAX NTRK1 BCL2L11 MAPK11 BRCA2 CASP2 KAT5 FASN CHEK1 PIN1 ADA RAD51 TP53AIP1 CDC2 CLCA2 FLOT2 CDK2 TP73 AEN TUBA1A TP63 PLK1 S100A2 CCNB1 SFN PLK3 SERPINA1 HEY2 SP1 WWOX WT1 MYC YAP1 MAPK14 BIN1 TP53I3 RELA MDM2 FOXO3A CDK6 JAK1 BBC3 GATA1 JAG2 ITCH RB1 CDKN1A RNF43 UBE4B HAGH PFDN5 FBXO45 PLPP1 GRAMD4 EP300 HSF1 DEDD D4S234E DCP1B AFP RCHY1 PID_WNT_CANONICAL_PATHWAY%MSIGDB_C2%PID_WNT_CANONICAL_PATHWAY PID_WNT_CANONICAL_PATHWAY PI4K2A AXIN1 DVL1 DVL2 DVL3 FZD5 GSK3A WNT3A APC CTNNB1 GSK3B STM7 LRP6 PPP2R5A KLHL12 CSNK1G1 NKD2 PID_KIT_PATHWAY%MSIGDB_C2%PID_KIT_PATHWAY PID_KIT_PATHWAY PTPRO PIK3C2B SPRED1 STAP1 SOCS1 BAD SHC1 STAT3 PIK3R1 GSK3B LYN SNAI2 GRB10 SH2B3 FOXO3A TEC CREBBP PTEN GRAP2 MAP2K1 PTPN11 FER MAPK3 CRKL EPOR PDPK1 RPS6KB1 PIK3CA CBL EPO KITLG MAPK8 KIT BCL2 GRB2 SOS1 MATK HRAS MAP2K2 DOK1 STAT1 RAF1 VAV1 SH2B2 PTPN6 MAP4K1 BIOCARTA_MSP_PATHWAY%MSIGDB_C2%BIOCARTA_MSP_PATHWAY BIOCARTA_MSP_PATHWAY CCL2 TNF CSF1 MST1R IL1B PID_ERBB1_INTERNALIZATION_PATHWAY%MSIGDB_C2%PID_ERBB1_INTERNALIZATION_PATHWAY PID_ERBB1_INTERNALIZATION_PATHWAY EGFR SH3GL2 HGS ITSN1 UBE2D1 UBE2D2 ZFYVE28 CHMP3 AMPH STAMBP NRAS TSG101 ARHGEF7 PIK3CD LRIG1 PIK3R3 PIK3R2 UBE2D3 SHC1 PIK3R1 SYNJ1 SRC KRAS EPN1 RAB5A CDC42 PIK3CA CBL GRB2 SOS1 HRAS EGF RAF1 SPRY2 BIOCARTA_ERK5_PATHWAY%MSIGDB_C2%BIOCARTA_ERK5_PATHWAY BIOCARTA_ERK5_PATHWAY MAPK3 MAPK7 SHC1 PIK3R1 PLCG1 PIK3CA NTRK1 CREB1 RPS6KA1 GRB2 MAPK1 HRAS BIOCARTA_CTBP1_PATHWAY%MSIGDB_C2%BIOCARTA_CTBP1_PATHWAY BIOCARTA_CTBP1_PATHWAY UBE2I SUMO1 CTBP1 UBA2 SAE1 PID_FGF_PATHWAY%MSIGDB_C2%PID_FGF_PATHWAY PID_FGF_PATHWAY FGF7B SPP1 MMP9 CTNND1 SDC2 FGFR1 FGF6B JUN FGF8 FGF9 FGF8A MAPK1 FGF23 RUNX2 FGF18 PAK4 FGFR4 FGFR3 BGLAP FGFR2 SHC1 CAMK2A PIK3R1 SRC NCAM1 CDH2 PTPN11 MAPK3 PDPK1 PLAUR PLCG1 PIK3CA CBL FGF7A STAT5B GRB2 SOS1 PTK2B FRS2 MET FOS HGF STAT1 SSH1 RPS6KA1 SPRY2 FGF2 BIOCARTA_DEATH_PATHWAY%MSIGDB_C2%BIOCARTA_DEATH_PATHWAY BIOCARTA_DEATH_PATHWAY GAS2 BIRC2 BIRC3 TNFRSF25 NFKBIA CHUK RELA TRADD TRAF2 RIPK1 MAP3K14 CASP10 NFKB1 CASP6 SPTAN1 TNFSF10 BCL2 CASP9 CASP8 CASP3 LMNA FADD DFFB DFFA APAF1 PID_MYC_REPRESS_PATHWAY%MSIGDB_C2%PID_MYC_REPRESS_PATHWAY PID_MYC_REPRESS_PATHWAY RBL1 NFYA CREB1 NFYB NFYC CEBPA GFI1 CLU FTH1 SFRP1 TMEFF2 CSDE1 TBP TMEM126A ALDH9A1 S100A7 NDRG2 GTF2H2 MXD4 IRF8 CEBPD PTPA CCND1 TSC2 DKK1 SPI1 HDAC1 GADD45A SP1 MAX ID2 MYC HDAC3 DNTT ITGA6 FOXO3A SMAD2 SMAD4 ITGB4 BCL2 ERBB2 CDKN2B CDKN1A CDKN1B ITGB1 BRCA1 COL1A2 EP300 DDIT3 CCL5 BIOCARTA_CELLCYCLE_PATHWAY%MSIGDB_C2%BIOCARTA_CELLCYCLE_PATHWAY BIOCARTA_CELLCYCLE_PATHWAY CDKN2C CDKN2A CCNB1 CDC2 RBL1 TFDP1 CDK2 CCNE1 CDKN2B CDK7 RB1 CCNH CDKN1A CDKN1B CDKN2D CCND1 CCND3 CCND2 CDK6 CDK4 BIOCARTA_CBL_PATHWAY%MSIGDB_C2%BIOCARTA_CBL_PATHWAY BIOCARTA_CBL_PATHWAY SH3GLB1 PDGFRA EGFR SH3GLB2 PRKCA EGF MET CSF1R CBL GRB2 PRKCB BIOCARTA_NTHI_PATHWAY%MSIGDB_C2%BIOCARTA_NTHI_PATHWAY BIOCARTA_NTHI_PATHWAY MAP2K6 SMAD4 TNF NFKB1 NR3C1 TGFBR1 TGFBR2 MAP2K3 MAPK14 IKBKB NFKBIA CHUK RELA EP300 MAPK11 MAP3K7 IL1B CREBBP CXCL8 MYD88 MAP3K14 PID_INTEGRIN1_PATHWAY%MSIGDB_C2%PID_INTEGRIN1_PATHWAY PID_INTEGRIN1_PATHWAY SPP1 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 ITGAV NPNT JAM2 NID1 PLAUR CSPG4 COL2A1 COL6A1 COL11A2 COL5A2 FGA HEL-S-78p TGFBI VCAM1 VEGFA ITGA4 ITGA2 ITGA1 COL1A1 VTN IGSF8 CD81 ITGA7 THBS2 ITGA6 FBN1 COL18A1 LAMA5 LAMA4 LAMC2 CD14 LAMC1 F13A1 LAMB3 ITGB1 LAMB2 LAMA1 LAMB1 LAMA3 COL3A1 TNC COL1A2 THBS1 MDK BIOCARTA_GATA3_PATHWAY%MSIGDB_C2%BIOCARTA_GATA3_PATHWAY BIOCARTA_GATA3_PATHWAY NFATC2 MAP2K3 NFATC1 MAPK14 PRKAR1B PRKAR1A PRKACG IL13 IL4 GATA3 IL5 BIOCARTA_RAS_PATHWAY%MSIGDB_C2%BIOCARTA_RAS_PATHWAY BIOCARTA_RAS_PATHWAY RALBP1 MAP2K1 MAPK3 RALA NFKB1 FOXO4 PIK3CA ARHA HRAS BAD PIK3R1 CASP9 CHUK RELA RAF1 CDC42 RAC1 BIOCARTA_IGF1_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1_PATHWAY BIOCARTA_IGF1_PATHWAY MAP2K1 PTPN11 MAPK3 IGF1 PIK3CA IGF1R JUN MAPK8 GRB2 SOS1 CSNK2A1 HRAS SHC1 PIK3R1 FOS RAF1 IRS1 BIOCARTA_PYK2_PATHWAY%MSIGDB_C2%BIOCARTA_PYK2_PATHWAY BIOCARTA_PYK2_PATHWAY MAP2K1 PRKCA MAPK3 CRKL PLCG1 CALM1 PAK1 JUN MAPK8 GRB2 MAPK1 SOS1 PTK2B HRAS MAP2K2 MAP2K3 MAPK14 SHC1 MAP2K4 MAP3K1 RAF1 RAC1 PRKCB PID_AR_PATHWAY%MSIGDB_C2%PID_AR_PATHWAY PID_AR_PATHWAY KDM1A UBE2I PAWR RANBP9 XRCC5 MED1 NKX3-1 CARM1 UBA3 PELP1 CDK6 TMPRSS2 KLK3 CDKN2A KDM3A TMF1 TGFB1I1 TGIF1 FHL2 ZMIZ1 PATZ1 APPL1 SVIL KDM4C NCOA6 PIAS1 PTK2B PA2G4 LATS2 VAV3 CTDSP1 MAK CTDSP2 ZNF318 SNURF CTNNB1 CCND1 CMTM2 PRKDC BRCA1 CASP8 CCND3 TCF4 FKBP4 UBE3A RPS6KA3 BIOCARTA_AT1R_PATHWAY%MSIGDB_C2%BIOCARTA_AT1R_PATHWAY BIOCARTA_AT1R_PATHWAY EGFR MAP2K1 PRKCA MAPK3 CALM1 PAK1 JUN MAPK8 GRB2 MAPK1 SOS1 PTK2B HRAS MAP2K2 SHC1 ATF2 MAP2K4 MAP3K1 AGTR1 RAF1 RAC1 PRKCB BIOCARTA_CCR5_PATHWAY%MSIGDB_C2%BIOCARTA_CCR5_PATHWAY BIOCARTA_CCR5_PATHWAY PRKCA CCL2 PLCG1 CXCL12 CCL4 CALM1 JUN MAPK8 PTK2B MAPK14 CCR5 FOS CXCR4 PRKCB BIOCARTA_EPONFKB_PATHWAY%MSIGDB_C2%BIOCARTA_EPONFKB_PATHWAY BIOCARTA_EPONFKB_PATHWAY CDKN1A EPOR NFKBIA NFKB1 GRIN1 RELA EPO HIF1A CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway CSF2 CREM FASLG AKAP5 PTGS2 CABIN1 CHP1 PRKACA JUNB JUN BATF3 POU2F1 NFATC3 NFATC2 NFATC1 FOS IL2 FOSL1 FKBP1A IL4 IL3 RCAN1 CD40LG IFNG RCAN2 IL2RA CALM3 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling JUN FOS ATF2 CDKN1A CITED1 ITGB5 SERPINE1 LAMC1 NR3C1 MED15 SIN3B SIN3A MYC HNF4A SNIP1 AKT1 EP300 NCOA1 IL10 TGIF1 PIAS4 PIAS3 NCOA2 MEF2C TGIF2 TFE3 FOXH1 RUNX3 RUNX2 SAP30 RUNX1 KAT2B AR KAT2A RBL1 TFDP1 CREB1 NCOR1 MYOD1 IRF7 ATF3 DLX1 CEBPB HDAC2 CBFB HDAC1 CTBP1 MAX FOXG1 GATA3 FOXO4 FOXO3 FOXO1 RBBP4 GSC SAP18 RBBP7 E2F4 E2F5 IGHA1 NKX2-5 SKIL SMAD2 ZBTB17 HSPA8 SMAD4 CREBBP CDKN2B SMAD3 VDR IFNB1 ESR1 SMAD7 SKI IL5 COL1A2 SP1 CDK4 SP3 CDK2 TCF3 DCP1A IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events SOCS3 IL18RAP STAT4 IL12B CCL2 IL12RB1 JAK2 STAT5A NOS2 ITGA3 STAT1 STAT3 IL18 IL19 TYK2 NFKB1 NFKBIA CD4 IL6 PIK3CA IL23A IL1B IL17F IL18R1 IL17A IL2 IFNG CXCL9 IL23R IL24 ALOX12B CXCL1 PIK3R1 CD3E TNF MPO RELA SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression RAN HDAC1 PIAS2 PIAS1 RANBP2 HDAC4 XPO1 UBE2I SUMO1 MDM2 RANGAP1 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events NFKB1 NFKBIA PIK3CA JUN FOS ROCK2 ITGB3 ILK CDC42 MAPK8 PLAU SPP1 MAPK1 PIP5K1A PTK2B ITGAV RAC1 MAPK3 VAV3 GSN MAP3K1 SYK CHUK MMP2 MMP9 RHOA MAP3K14 CD44 BCAR1 PIK3R1 RELA ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events TGFB1 TGFB3 CAV1 GDF2 SMAD9 INHBA ACVR2B SMAD5 ACVR2A TGFBR1 TGFBR2 PPP1CA TLX2 ID1 CSNK2B ENG FKBP1A SMAD4 MAPK1 SMAD7 MAPK3 ACVRL1 BMPR2 ARRB2 ACVR1 SMAD1 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase CREB1 RET GRB7 SRC PRKACA IRS1 PIK3CA SHC1 JUN PXN IRS2 RAP1A GRB10 HRAS PDLIM7 NCK1 GAB1 FRS2 GFRA1 PRKCA PTPN11 PTK2 DOK1 DOK4 GDNF DOK5 DOK6 MAPK8 RASA1 GRB2 SOS1 MAPK1 SHANK3 CRK RAC1 MAPK3 RHOA BCAR1 PIK3R1 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events TGFB1 COL5A2 COL6A1 COL4A3 COL4A6 SDC1 COL6A3 COL4A5 HPSE PPIB FGFR4 MET FGFR3 PRKACA MAPK1 LAMA5 COL11A1 COL11A2 SDCBP MAPK3 COL1A2 CCL5 BSG FGF23 MMP7 MMP1 HGF CASK MMP9 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 COL6A2 FGF19 COL4A4 COL7A1 REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation CAMK2B RASGRF2 RASGRF1 RASAL1 RASGRP2 PRKCZ RASGRP1 RASGRP4 RASGRP3 LGALS3 RABGEF1 NRAS LGALS1 SYNGAP1 HRAS RRAS PLCE1 PRKCB PRKCE DAB2IP PRKCA RASA4 RASA2 NF1 KRAS RIN1 SOS2 CALM3 RASA1 GRB2 SOS1 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling INCENP AURKC AURKB H3-3B IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events SOCS3 JAK2 STAT5A PIK3CA IL4 CD40LG ITGB3 PIGR SPI1 ETS1 IGHG3 IGHG1 MYB IL13RA2 JAK3 MYBL1 JAK1 AKT1 IL13RA1 IL4R ARG1 IL10 GTF3A OPRM1 FCER2 DOK2 IRF4 LTA TFF3 IGHE RETNLB CCL11 ALOX15 THY1 CBL IL2RG SOCS1 INPP5D STAT6 CCL17 SOCS5 STAT5B EGR2 HMGA1 MAPK14 PARP14 CEBPB MTOR AICDA SELP BCL6 RPS6KB1 IRS1 FES SHC1 PTPN6 CCL26 IRS2 BCL2L1 GRB2 IL5 COL1A2 SP1 COL1A1 PIK3R1 IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K IL2RG MTOR NFKB1 PRKCZ RPS6KB1 PIK3CA SHC1 BCL2L1 SGMS1 FOXO3 UGCG TERT SMPD1 E2F1 IL2 HSP90AA1 RPS6 GAB2 LCK PTPN11 IL2RB BCL2 EIF3A IL2RA CALM3 GRB2 SOS1 MYB RAC1 MYC JAK3 JAK1 AKT1 PIK3R1 RELA SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling VEGFA AFDN TEK JAK2 STAT1 PRKACA IL6 PIK3CA NRAS IL2 IFNG KRAS IL2RA JAK3 JAK1 RHOA IL2RG IRS1 SHC1 HRAS GAB1 FRS2 GAB2 LCK PTPN11 IL2RB ARHGAP35 IGF1R KDR IL6R PDGFRB MAP2K1 GRB2 MAP2K2 SOS1 LMO4 IFNGR1 NGF FRS3 IL6ST RAF1 SDC2 PDGFB GNAI3 GNAI1 EGFR NTF4 NTF3 PAG1 NTRK1 NTRK2 ANGPT1 PIK3R1 BDNF NOS3 EGF NTRK3 IGF1 NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network RUNX2 RB1 CAMK2D AR CDKN1B NOTCH1 JAK2 KDM1A MAML2 MAML1 NCOR1 GATA6 MYOD1 TWIST1 STAT3 GATA4 ASCL1 RBPJ GATA1 HIF1A HDAC1 GHR CD4 CTBP1 YY1 HEY1 BGLAP HEY2 RBBP8 HES1 SPEN HES6 TLE1 E2F1 PARP1 GAA ARNT NCOR2 PTF1A RCAN1 NEUROG3 KDR CREBBP MYB EP300 TCF3 NCOA1 INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions ITGA3 ITGB1 ITGAM ITGB4 ITGB3 ITGB2 ITGA2B ITGAE ITGAL ITGAX ITGB5 ITGB8 ITGB7 ITGB6 ITGA4 ITGAV ITGA2 ITGA1 ITGAD ITGA10 ITGA11 ITGA8 ITGA7 ITGA6 ITGA5 ITGA9 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events PAK1 FZR1 CCNB1 PPP2R1A CLSPN FBXO5 ECT2 BTRC NINL BUB1 CENPU NUDC PPP1R12A BORA FBXW11 ODF2 PLK1 CDC25C TUBG1 NDC80 CDC25B SGO1 TPX2 CENPE WEE1 STAG2 KIF2A PRC1 GORASP1 CDK1 KIF20A KIZ SPC24 TPT1 ROCK2 INCENP RAB1A RHOA ERCC6L BUB1B AURKA CDC14B PPP1CB PPP2CA GOLGA2 CDC20 BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events RBBP8 PCNA MRE11 PRKDC UBE2D3 BRCA1 UBE2L3 CSTF1 NBN TOPBP1 BARD1 XRCC6 XRCC5 FANCL FANCA FANCC FANCE FANCG FANCF CDK2 RAD50 RAD51 CCNE1 EWSR1 FANCD2 ATM TP53 ATR S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway GNAI2 GNAI3 GNAI1 RHOA GNAO1 GNAZ GNA12 S1PR5 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma YWHAE GSK3B YWHAB CAMK2A AGAP2 CCND1 YWHAQ STAT5A EPB41L1 CREB1 SFN PLCG1 YWHAG YWHAH EGR1 TRPC3 PDPK1 BAD PRKCD SRC TRPV1 YWHAZ PIK3CA SHC1 CAMK4 FOXO3 NRAS HRAS GAB1 KRAS GRB2 SOS1 NGF AKT1 NTRK1 PIK3R1 IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 TGFB1 IL18RAP STAT4 STAT3 IL18 CD4 JUN CD86 CD80 PRF1 IL18R1 CD3G CD3D MAPK9 FOS TBX21 IL2 IL13 ETV5 IRF1 CD28 HLA-DRA PIAS2 CD247 IFNG HLA-DRB1 IL2RA CREBBP MAPK8 CD3E AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling BUB1 NDC80 SGO1 KIF20A CUL3 CDCA8 NCAPG INCENP PEBP1 AURKC KLHL13 AURKB RASA1 SMC4 H3-3B CENPA NCAPH MYLK SMC2 PPP1CC RACGAP1 STMN1 EVI5 NPM1 CBX5 SEPTIN1 NSUN2 PPP2R5D KIF23 RHOA KLHL9 PSMA3 DES AURKA NCL BIRC5 NCAPD2 KIF2C TACC1 VIM NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events TRIO PAK1 PITPNA WASL NTN1 CAMK2A FYN AGAP2 YES1 UNC5A MYO10 DCC UNC5B PLCG1 DAPK1 UNC5C MAP1B ELMO1 DOCK1 SRC PIK3CA NCK1 PTK2 CDC42 MAP2K1 MAP2K2 MAPK1 RAC1 MAPK3 RHOA BCAR1 PIK3R1 S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway GNAI2 CDC42 MAPK1 PLCG1 GNA13 MAPK3 S1PR4 GNAI3 GNAI1 RHOA GNAO1 GNAZ GNA12 S1PR5 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events PDE3B PIK3CG PIK3R6 MAP2K1 MAPK1 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network ATP2B1 LYZ SMARCA2 HIPK2 KITLG CDKN1B CDK6 CCND1 MYF6 TAB2 TAB1 ADA PTGS2 GATA1 CD4 NRAS HES1 UBE2I KRAS CDKN1A SPI1 ETS1 MYB SIN3A MYC EP300 PIAS3 CCNB1 NCOR1 MYOD1 CEBPB SLC25A3 LECT2 GATA3 CLTA YEATS4 ETS2 PPP3CA HRAS CA1 TRIM28 CASP6 ANPEP TOM1 PIM1 RAG2 CD34 BCL2 MAP3K7 PTCRA PAX5 HSPA8 SND1 CCNA1 CREBBP MAF ADORA2B TFEC KIT MCM4 PRTN3 ZFPM1 SKI PPID MAD1L1 COL1A2 BIRC3 SP1 CEBPA CSF1R COPA CEBPD LEF1 IQGAP1 NLK MAT2A WNT1 ELANE H2AZ1 ZFHX3 GSTM1 MPO CBX4 CDKN2A EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling PAK1 WASL ROCK1 ITSN1 EFNA5 KALRN RAP1B EFNB2 EFNB1 GRB7 EFNB3 SRC EPHB2 EPHB1 PIK3CA SHC1 EPHB4 PXN MAP4K4 EPHB3 NRAS RAP1A DNM1 TF HRAS SYNJ1 RRAS NCK1 PTK2 KRAS CDC42 RASA1 MAP2K1 GRB2 MAPK1 CRK RAC1 MAPK3 PIK3R1 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway MAPK14 FASLG PDPK1 SRC PIK3CA CLTC MAPK9 SMPD1 FAIM2 PIK3CB IKBKB CASP8 CASP10 CASP3 RIPK1 IKBKG FADD MAP2K7 BID MAP2K6 MAPK8 RFC1 CFLAR MAPK10 MAPK11 BTK FAS EZR BIRC2 BIRC3 MAP3K1 AKT1 SYK CHUK PIK3R1 PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events PLK2 PLK4 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway TNFRSF1A PRKRA MADD RB1 CYCS BAX NSMAF NFKB1 BAD NFKBIA PRKCZ PRKCD MAP4K4 SMPD1 CASP8 RIPK1 BCL2 FADD BID MAPK8 MAP2K1 MAP2K2 MAPK1 MAPK3 RAF1 MYC BIRC3 ASAH1 TRADD MAP3K1 PDGFA AKT1 SMPD3 BAG4 AIFM1 CTSD EIF2A MAP2K4 KSR1 CRADD SPHK2 TNF EGF EIF2AK2 PAWR RELA TRAF2 IGF1 ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling FYN YES1 PRKN BLK MAOB PARK7 PLD1 SLC6A3 PLD2 KLK6 UCHL1 GRK5 SNCA BAD LYN PRKCD SRC TOR1A CSNK2A1 SNCAIP FGR HCK TH STUB1 PLCB2 FKBP1A LCK UBE2L3 PTK2B SYK PPP2R5D ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway BTRC MAPK14 NFKB1 NFKBIA SRC SYK PIK3CA BCL3 PIK3R1 REL ARRB2 IKBKB RELA LCK RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway CDKN1B ROCK1 PLD1 PLD2 PPP1R12A PRKCZ JUN FOS SRF PTEN SLC9A1 PARD6A CFL1 ITGB1 PIP5K1B PIP5K1C ROCK2 CCN1 SCAI SH3GL2 ATF2 CDC42 MAP2K6 MAP2K3 MAPK8 LIMK2 LIMK1 RDX MSN PIP5K1A MRTFA MAPK12 CIT EZR DIAPH1 ACTA1 SLC9A3 MYL2 PKN2 PKN1 TLN1 F2RL2 VCL RHOA MAP2K4 SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B INS SOCS3 CSK PTPN1 INSR FER FCGR2A JAK2 TRPV6 STAT5A LEP NOX4 SPRY2 LAT STAT3 TYK2 PIK3CA ITGB3 ITGA2B AKT1 RHOA BCAR1 CAV1 FYN YES1 BLK STAT5B LYN SRC IRS1 SHC1 FGR HCK LCK DOK1 PDGFRB GRB2 CRK PDGFB CSF1R EGFR CSF1 PRL YBX1 CSN2 CDH2 PIK3R1 LEPR CAPN1 EGF PRLR TXN SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events TGFB1 BAX FGFR4 CSF2 CXCL8 FGFR3 TNFRSF13B LAMA1 EPB41 LAMA3 KNG1 RACK1 PRKCD SRC PRKACA EPHB2 CAV2 TRAPPC4 FN1 HRAS CASP3 ITGB1 NF1 MAPK8 RASA1 MAPK1 ITGA2 EZR SDCBP MAPK3 SDC2 FGF23 MMP2 CASK RHOA FGF19 RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway KRAS MAP2K1 MAPK1 RAF1 MAPK3 BRAF ELK1 NRAS MAP3K8 PTPN7 HRAS FOS PRKCB PRKCA ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network INS SOCS3 RB1 CCND1 NOS2 CXCL8 IL6 JUNB IL23A JUN POU2F1 HES1 HRK ACHE FOS MAPK9 CSRP2 DUSP10 KAT5 RUVBL2 DUSP5 PDGFRA DUSP1 NF1 DUSP8 IFNG SERPINB5 CUL3 CCNA2 DDIT3 ATF2 JDP2 MACROH2A1 MAPK8 PLAU PPARGC1A TGFB2 MAPK1 JUND MAPK11 COL24A1 HBG2 GADD45A SELE MAPK3 EP300 ARG1 MMP2 CREB1 ATF3 MAPK14 CBFB BCL2L1 TH PRKCA BCL2 BRCA1 ESR1 CDK4 EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling CBL FYN YES1 BLK ROCK1 PLCG1 EFNA5 LYN SRC PIK3CG PIK3R6 FGR HCK LCK CRK CRKL VAV3 EPHA5 EPHA4 EPHA7 EPHA6 ARHGEF15 EPHA8 VAV2 RHOA EFNA1 EFNA3 EFNA2 CDK5 EPHA1 EPHA3 NGEF EPHA2 SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I STAT3 GATA1 NFKB1 NFKBIA YY1 PRKACA RANBP2 HDAC4 XPO1 UBE2I SUMO1 NCOR2 RANGAP1 RAN SIN3B SIN3A EP300 HDAC10 HDAC11 TNFRSF1A CHD4 SAP30 CHD3 MBD3L2 KAT2B SMG5 PRMT5 SIRT4 BTRC SIRT5 SIRT6 SIRT7 NCOR1 SIRT1 SIRT2 WDR77 SIRT3 PPARG FKBP3 HDAC2 HDAC5 HDAC3 HDAC1 HDAC8 MAX GATA2 HDAC9 NR2C1 HDAC6 HDAC7 MTA2 RBBP4 MBD3 SMURF1 SAP18 MBD2 RBBP7 GATAD2B GATAD2A TFCP2 MXD1 CREBBP SMAD7 ZFPM1 TNF RELA ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events INS ITGA3 PLD1 PLD2 CLTC RALA ITGB1 CTNND1 SLC2A4 PIP5K1C ADRB2 ASAP2 KLC1 CDH1 CTNNA1 SPAG9 EXOC7 AVPR2 MAPK8IP3 ITGA4 TSHR ITGAV ITGA2 DNM2 ITGA1 NME1 SCAMP2 ACAP1 ITGA10 BIN1 ITGA11 ITGA8 EXOC4 AGTR1 ITGA7 EXOC3 ITGA6 CPE ITGA5 CTNNB1 ITGA9 EXOC6 EXOC5 EXOC2 VAMP3 EXOC1 ARF6 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling USP7 YWHAE MST1 CSNK1D YWHAB CSNK1E RBL2 CDKN1B CAT SGK1 YWHAQ CSNK1G2 CSNK1G1 RALB SFN BCL2L11 YWHAG CSNK1A1 YWHAH SOD2 FASLG FBXO32 G6PC1 YWHAZ MAPK9 XPO1 IKBKB RAN MAPK8 MAPK10 GADD45A AKT1 EP300 CHUK CCNB1 KAT2B SIRT1 PLK1 BCL6 FOXO4 FOXO3 FOXO1 RALA CREBBP CDK2 CTNNB1 ZFAND5 SKP2 CSNK1G3 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway GNAI2 ABCC1 GNA13 SPHK1 S1PR4 SGPP1 GNAI3 GNA14 GNAI1 GNA15 SGPL1 GNA11 GNAQ S1PR1 S1PR3 S1PR2 SPHK2 GNAO1 GNAZ GNA12 S1PR5 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt YWHAE GSK3B YWHAB CDKN1B YWHAQ SFN YWHAG YWHAH MTOR PDPK1 BAD SRC PRKACA YWHAZ FOXO4 BCL2L1 FOXO3 FOXO1 GSK3A MAPKAP1 CASP9 HSP90AA1 AKT2 AKT3 MLST8 RICTOR KPNA1 SLC2A4 MAP3K5 TBC1D4 PRKDC CDKN1A RAF1 AKT1 CHUK E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction AFDN CCND1 RAP1B SRC PIK3CA RAP1A CTNND1 PIP5K1C CYFIP2 NCKAP1 ITGAE CDC42 CDH1 WASF2 CTNNA1 AP1M1 JUP KLHL20 ITGB7 ENAH TJP1 CRK TIAM1 DLG1 RAC1 NME1 CTTN ABI1 RAPGEF1 AKT1 IQGAP1 VAV2 CTNNB1 RHOA PIK3R1 ARF6 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family GAS1 CDON TGFB2 LRPAP1 STIL DHH PIK3CA AKT1 HHIP PTCH1 PTCH2 IHH LRP2 PTHLH GLI2 PIK3R1 HHAT SHH ARRB2 GRK2 SMO BOC POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle PLK2 PLK1 PLK3 PLK4 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway STAT5A STAT3 JUN MAPK9 CYFIP2 MAP2K7 NCKAP1 ATF2 WASF2 MAP2K6 MAPK8 PIP5K1A RAC1 RACGAP1 ABI1 MAP3K1 MAP2K4 BCAR1 PAK1 NCF1 NCF2 ARPC1B BRK1 ARHGAP5 ARHGDIA ACTR3 ACTR2 CYBB CYBA MAPK14 NOXO1 IQGAP3 WASF1 PAK2 ARPC4 ARPC5 BAIAP2 ABI2 ARPC2 ARPC3 NOXA1 NOX1 PLCB2 MAP3K11 CFL1 PIP5K1B PIP5K1C CDH1 MAP2K3 CTNNA1 LIMK1 CRK IQGAP1 CTNNB1 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones ARR3 GUCY2F RPE65 GRK1 GNGT2 RDH12 GNAT2 RGS9BP GRK7 RDH5 CNGB3 GNB3 PDE6C CNGA3 LRAT GNB5 RGS9 SLC24A2 GUCY2D PDE6H GUCA1B GUCA1A GUCA1C REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity ARHGEF9 DNMBP APC SPATA13 ARHGEF7 ARHGEF6 ARHGDIA PLCG1 ITSN1 CDC42 RACGAP1 NME1 VAV3 BCAR3 DOCK6 ITSN2 ARHGEF25 DOCK9 ARHGAP1 VAV2 ARHGAP17 FGD1 DOCK10 DOCK11 MCF2L GIT1 FARP2 NGEF RALBP1 MCF2 HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network VEGFA FLT1 EPO EPAS1 CITED2 SLC2A1 SIRT1 TWIST1 PGK1 ELOB HIF1AN VHL ELOC EGLN1 EGLN3 EGLN2 SLC11A2 POU5F1 MMP14 ELK1 ADORA2A APEX1 BHLHE40 EIF3E FXN ABCG2 ARNT KDR CREBBP SERPINE1 ETS1 SP1 EP300 EFNA1 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity GSK3B SMARCA2 EGR1 RACK1 JUN POU2F1 EHMT2 KAT5 ZMIZ2 TRIM24 MDM2 KAT7 SMARCC1 SENP1 PDE9A TMPRSS2 KLK3 KLK2 RCHY1 MAP2K6 NR2C2 MAPK8 HOXB13 RXRB RXRA SRY NR3C1 RXRG SPDEF SMARCE1 NR0B1 DNAJA1 APPBP2 CARM1 EP300 NCOA1 MAP2K4 NCOA2 KAT2B AR SIRT1 MAPK14 HDAC1 SRC GATA2 NR2C1 HDAC7 FOXO1 REL HSP90AA1 CREBBP CEBPA PKN1 PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway PDGFRA CAV1 GRB2 SOS1 PLCG1 CRK ITGAV CRKL RAPGEF1 JAK1 CAV3 CSNK2A1 PIK3CA JUN SHC1 SHB SHF ELK1 FOS PIK3R1 SRF SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events AGRP FYN FGFR4 CXCL8 FGFR3 CTTN SRC FGF23 EGFR PSENEN CASK NCAN SDC3 PTN PSEN1 POMC MC4R APH1A FGF19 NCSTN APH1B SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta ATF1 GDI1 HSPB1 RPS6KA4 ELK4 RPS6KA5 MKNK1 EIF4EBP1 NOS2 CREB1 EIF4E MEF2A KRT8 PLA2G4A MAPK14 MITF CEBPB USF1 PTGS2 KRT19 MAPKAPK3 MAPKAPK2 MAPKAPK5 HBP1 JUN ATF6 RAB5A SLC9A1 DDIT3 ATF2 PPARGC1A MAPK11 ESR1 TP53 MEF2C ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events DOCK1 SRC PRKACA YWHAZ FN1 PXN IGSF8 CD81 THBS2 THBS1 ADAM28 MDK CD14 PRKACB JAM2 VCAM1 MYH2 ITGB1 PTK2 PRKAR1B JAML PRKAR1A PTPRA SPP1 CRK PTK2B ITGA4 RAC1 ABI1 TLN1 BCAR1 GIT1 ARF6 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network LRP5 FZD10 LRP6 WIF1 RSPO1 WNT2 WNT3 CTHRC1 FZD1 FZD2 FZD5 FZD4 WNT3A IGFBP4 RYK FZD7 WNT7B FZD6 WNT5A ATP6AP2 WNT1 FZD9 KREMEN1 FZD8 WNT7A KREMEN2 DKK1 ROR2 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network CRTC1 DMP1 MT2A GJA1 NPPA CCL2 CDKN1B TIMP1 CCND1 EDN1 HLA-A ELF1 DMTF1 NTS BCL2L11 CSF2 CXCL8 PENK BAG1 EGR1 TCF7L2 AGT FOSL2 HIF1A FABP4 COPS5 IL6 MAFG JUNB TRIP6 JUN FOSB NFATC3 NFATC2 NFATC1 FOS IL2 FOSL1 IL4 DUSP1 IFNG ATF2 PLAU JUND ETS1 NR3C1 MYB MYC EP300 IL10 MMP9 TGFB1 CREB1 ATF3 CBFB GATA2 TH PTEN CDK1 CCN1 MAF ESR1 IL5 ACTA1 COL1A2 SP1 MMP1 CTNNB1 TP53 CDKN2A IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events PTPN11 JAK2 STAT5A GRB2 STAT5B IL5 SDCBP LYN PIK3CA CISH IL5RA CSF2RB PIK3R1 PIM1 INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling GSK3B ARHGEF7 ARHGEF6 CCND1 CREB1 PPP1R12A JUN PXN RUVBL1 NCK2 ILKAP XPO1 TNS1 PARP1 GIT2 HSP90AA1 PPP1R14A RUVBL2 PPP1R14B PPP1R14C RICTOR ACTN1 RHOG PARVA PARVB CKAP5 ILK ZEB1 CDC42 PARVG NACA CDC37 SNAI1 TACC3 ZYX ELMO2 MYL9 RAC1 DIAPH1 LIMS2 LIMS1 AKT1 IQGAP1 CTNNB1 AURKA N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events PTPN1 GJA1 FER ROCK1 PLCG1 PIK3CA PTPN11 CTNND1 PIP5K1C LRP5 CALM3 CDC42 MAPK8 CTNNA1 JUP RAC1 CTTN GRIA2 DAGLA GSN MYL2 DCTN1 CNR1 KIF5B CAMK2G AXIN1 CTNNB1 RHOA GAP43 MAPRE1 DAGLB FGFR1 PIK3R1 CDH2 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor MED1 TGFB1 SREBF1 NR1H2 NR1H4 NR1H3 NR4A1 RARA RARB PPARA PPARD PPARG RPS6KB1 NCOR2 BCL2 RXRB VDR RXRA RXRG NCOA1 RARG THRB THRA TNF FAM120B ABCA1 P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network TP63 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network CCND1 STAT5A JUN HDAC4 NCOR2 NR0B1 MYC EP300 CHUK NCOA1 CTSD NCOA2 MED1 NCOR1 COL18A1 CALCOCO1 CD82 MPG CEBPB SRA1 PHB2 DDX17 HDAC1 PDIA2 DSCAM NCOA3 AP1B1 DDX54 AXIN2 SAFB LCOR TRIM59 NCOA7 TFF1 PGR SET ANP32A PRDM15 NEDD8 PCNA C3 MTA1 HSF2 NRIP1 SMAD4 BRCA1 VTLGL1 APBB1 NDUFV3 ATP5PF LMO4 XBP1 KLRC3 ESR1 ABCA3 GREB1 POU4F1 NR0B2 ESR2 POU4F2 SOD1 UBA3 EBAG9 UBE2M PRL ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling TEK STAT5A ELF1 NFKB1 PIK3CA FN1 ELK1 ITGB1 CDKN1A MAPK8 MAPK1 ETS1 RAC1 MAPK3 AKT1 MMP2 ITGA5 DOK2 PAK1 FYN STAT5B PLD2 MAPK14 GRB7 RPS6KB1 FES SHC1 PXN FOXO1 NCK1 PTPN11 PTK2 RASA1 GRB2 CRK AGTR1 FGF2 GRB14 F2 ELF2 PLG ANGPT1 PIK3R1 ANGPT4 ANGPT2 NOS3 TNF BMX TNIP2 RELA DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells IFNA4 IFNA7 IFNA6 STAT4 IFNA2 IFNA8 TNFRSF4 B2M EOMES HLA-A IFNAR2 IFNA13 IFNA14 IFNA16 IFNA17 FASLG TNFRSF18 EGR1 CD8B CD8A PRKCQ IFNA10 IFNAR1 JUNB IFNA21 JUN EGR4 TNFRSF9 BRAF ELK1 GZMB PRF1 NRAS NFATC3 CD3G NFATC2 PTPN7 CD3D NFATC1 FOS MAPK9 IL2 PRKCB FOSL1 PRKCE CD247 IFNG KRAS IL2RA CALM3 MAPK8 MAPK1 MAPK3 IL2RG HRAS PRKCA IL2RB MAP2K1 MAP2K2 RAF1 CD3E TNF IFNA5 SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase ARHGEF7 CCND1 PLCG1 RAP1B PIK3CA JUN BRAF PTPN21 CAPN2 NCK2 SH3GL1 ARHGEF11 MAPK9 RRAS ARHGEF28 ASAP1 GIT2 ARHGAP26 KLF8 ACTN1 ITGB1 ROCK2 MAPK8 ITGB5 MAPK1 ETS1 ITGAV RAC1 RAPGEF1 ITGA5 RHOA MAP2K4 BCAR1 PAK1 WASL FYN YES1 ELMO1 DOCK1 GRB7 SRC PXN RAP1A NCK1 PTK2 ARHGAP35 RASA1 MAP2K1 GRB2 SOS1 MAPK8IP3 CRK ACTA1 RAF1 TLN1 VCL PIK3R1 BMX ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions LAMB3 LAMB2 LAMB1 ITGB4 LAMC2 ITGA6 LAMC1 LAMA5 LAMA1 LAMA2 LAMA3 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway CENPS RAD9A BTRC FBXW11 HES1 MRE11 H2AX BLM WDR48 BRCA1 FAAP24 BRCA2 BRIP1 NBN CHEK1 TOPBP1 USP1 ATRIP FAAP100 FANCI FANCL RFC5 FANCA RFC3 FANCC RFC4 FANCE FANCM FANCG RMI1 FANCF RFC2 RAD50 XRCC3 TOP3A RPA1 HUS1 FANCD2 RPA2 ATM FANCB PALB2 ATR UBE2T RAD17 RAD1 FAN1 VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms TOP2A GSK3B RUNX1 YAP1 STXBP4 RRAD NOTCH1 DLX5 DLX6 TBXT SEC14L2 SFN ITGA3 ADA CCNB2 TP63 PERP BDKRB2 HELLS GPX2 TCF7L1 FOSL2 FBXW7 RACK1 IGFBP3 ADRM1 WWP1 HBP1 PPP2R5A NRG1 KRT5 HES1 POU2F2 IL1A ITCH AXL FASN KRT14 RAB38 MDM2 MRE11 BRCA2 VDR CEBPD ATM COL5A1 CDKN2A CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis GZMB PRF1 PARP1 CASP9 CASP8 CASP10 CASP3 RIPK1 BID BIRC2 GSN TRADD MAP3K1 CRADD TRAF2 VIM TNFRSF1A SREBF1 MADD CYCS BAX CASP6 APP NUMA1 LMNB2 LMNB1 PTK2 BCL2 PIDD1 CASP7 SLK CFL2 CASP4 ARHGDIB CASP1 LIMK1 CASP2 OPG199 SPTAN1 DFFB DFFA APAF1 ACTA1 GAS2 TOP1 BIRC3 SATB1 DIABLO XIAP LMNA TFAP2A KRT18 TNF IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events CXCL8 REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity TRIO DEF6 BCR TIAM2 SPATA13 ARHGEF2 DOCK2 ARHGEF7 ARHGEF6 ARHGDIA RASGRF2 KALRN ELMO1 RASGRF1 DOCK1 SOS1 TIAM1 RACGAP1 RAC1 ABI1 VAV3 DOCK6 ARHGEF25 ARHGAP1 VAV2 ARHGAP9 ARHGAP17 RAP1GDS1 PREX2 EPS8 ABR PREX1 CHN2 NGEF CHN1 RALBP1 MCF2 VAV1 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling THY1 MST1 SELPLG LRP1 PLAT MST1R HMGB1 ROCK1 AGER ICAM1 CCN2 APOB RAP1B JAM3 PLAUR NFKB1 SELP LPA IL6 HCK RAP1A JAM2 MYH2 ITGAM ITGB2 PLAU TLN1 MMP2 MMP9 RHOA PLG TNF ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway PLD1 MAPK1 PIP5K1A PLD2 TIAM1 KALRN NME1 RAC1 PLAUR MAPK3 ARF1 RAB11A RAB11FIP3 RHOA ARF6 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells FER PLCG1 LAT NFKB1 SPHK1 PIK3CA ITK JUN WIPF1 CBLB FCER1A S1PR1 FCER1G NFATC2 LAT2 FOS HCLS1 LCP2 PRKCB MS4A2 IKBKB PLPP1 PLA2G1B KLRG1 PTPN13 DUSP1 FCGR2B IKBKG MAP2K7 MAPK8 MAPK1 BTK MAPK3 MAP3K1 AKT1 SYK CHUK MAP2K4 IGHE CBL FYN INPP5D PLA2G4A PLD2 PAK2 LYN SHC1 PXN HRAS GAB2 PTPN11 PTK2 DOK1 RASA1 MAP2K1 GRB2 MAP2K2 SOS1 RAF1 PIK3R1 VAV1 RELA S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway GNAI2 VEGFA FLT1 JAK2 GNA13 SRC GNA14 GNA15 GNA11 GNAQ S1PR3 AKT3 CXCR4 PDGFRB MAPK1 RAC1 MAPK3 PDGFB GNAI3 GNAI1 AKT1 RHOA GNAO1 GNAZ GNA12 A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling ITGB1 PTK2 MADCAM1 PXN RHOA ITGB7 ITGA4 VCAM1 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling CCND1 PLCG1 STAT3 RASGRF1 RAP1B PRKCZ PIK3CA DNM1 NRAS RHOG KRAS PRKCI DYNLT1 MATK CDC42 SQSTM1 FAIM SHC2 RGS19 MAPK1 SHC3 TIAM1 MAGED1 NEDD4L RAC1 ABL1 CRKL MAPK3 NGFR RAPGEF1 ARHGAP32 RIT1 RIT2 EHD4 GIPC1 DNAJA3 RHOA ELMO1 DOCK1 SHC1 RAP1A HRAS GAB1 FRS2 GAB2 PTPN11 RASA1 MAP2K1 GRB2 SOS1 CRK NGF FRS3 NTF4 NTF3 NTRK1 NTRK2 MCF2L PIK3R1 BDNF NTRK3 CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events ADAP1 ZAP70 ARF5 FYN INPP5D YES1 SGK1 BLK PLCG1 LAT PDPK1 ARF1 LYN SRC PIK3CG PIK3R6 PIK3CA ITK FGR HCK FOXO3 NRAS RAP1A HRAS PIK3CB HSP90AA1 PTEN LCK KRAS BTK RAC1 SYK INPPL1 DAPP1 RHOA CYTH3 CYTH2 PLCG2 PIK3R1 BLNK CYTH1 ARF6 PLEKHA1 PLEKHA2 ARAP3 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events YAP1 ERBB4 ERBB2 FYN LRIG1 JAK2 WWOX STAT5A NRG2 TAB2 CBFA2T3 STAT5B GRIN2B NCOR1 EREG BTC ADAM17 NRG3 NRG4 DLG4 NEDD4 HBEGF WWP1 PIK3CA SHC1 NRG1 ITCH PIK3CB MDM2 GRB2 MAPK1 MAPK3 PRL PIK3R1 PRLR GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events CCL2 INPP5D JAK2 STAT5A STAT5B STAT1 CSF2 STAT3 LYN CSF2RA PRKACA PRKACG YWHAZ PIK3CA SHC1 OSM CISH IRF8 CSF2RB NRAS HRAS FOS IKBKB PRKACB GAB2 PIM1 PTPN11 KRAS MAP2K1 GRB2 MAP2K2 SOS1 MAPK1 MAPK3 RAF1 SYK PIK3R1 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta PKN1 MAP2K3 EEF2K CCND1 MAP2K6 MAP3K20 MAPT MAPK13 SNTA1 MAPK12 STMN1 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction AFDN ROCK1 MET AQP5 NCK1 AQP3 LPP LIMA1 MYO6 MGAT3 ACTN1 CTNND1 STX4 PIP5K1C VASP PLEKHA7 CYFIP2 IGF1R CAMSAP3 NCKAP1 KIFC3 CDH1 NECTIN2 CTNNA1 ENAH ZYX DIAPH1 ABI1 MYL2 EXOC4 EGFR EXOC3 HGF CTNNB1 VCL RHOA EFNA1 GIT1 ARF6 EGF EPHA2 IGF1 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 VEGFA FLT1 ROCK1 PLCG1 PDPK1 ARF1 PRKCD PRKACA PIK3CA BRAF NCK2 PRKCB ITGB3 CALM3 CDC42 MAP2K6 MAPK1 MAPK11 PTK2B ITGAV MAPK3 AKT1 SHB RHOA CBL CAV1 FYN MAPK14 FBXW11 PAK2 NEDD4 MAPKAPK2 SRC FES PTPN6 PXN GRB10 NCK1 HSP90AA1 GAB1 PRKCA PTPN11 PTK2 KDR MAP2K3 HSP90AB1 CTNNA1 PTPRJ MAP2K1 GRB2 CDH5 MAP2K2 MYOF HGS SH2D2A DNM2 AKAP1 CAMKK2 RAF1 VTN PTPN2 VCL IQGAP1 CTNNB1 PIK3R1 NOS3 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation SUPT3H SUPT7L BCAT1 GAPDH PTMA SHMT1 TAF9 ODC1 IREB2 RPL11 SLC2A1 CDCA7 MTDH HSPD1 PRDX3 LDHA MYCT1 PDCD10 PMAIP1 E2F3 TAF12 HSPA4 TAF10 HUWE1 KIR3DL1 RUVBL1 EIF2S1 LIN28B GPAM POLR3D FOSL1 ID2 KAT5 RIOX2 RUVBL2 NDUFAF2 TAF4B SERPINI1 PFKM EIF4G1 SNAI1 MYC NPM1 EP300 MMP9 NCL BIRC5 CCNB1 BAX KAT2A EIF4E HMGA1 MAX TERT HSP90AA1 PIM1 MTA1 SMAD4 CREBBP SMAD3 NBN NME1 EIF4A1 CDK4 TFRC TRRAP ENO1 BMI1 CCND2 PEG10 UBTF RCC1 TK1 TP53 DDX18 ACTL6A CAD NME2 CDC25A REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta PAK1 FYN YES1 BLK TAB1 RALB MAPK14 PAK2 LYN SRC FGR HCK DUSP10 LCK RALA RIPK1 DUSP1 DUSP8 DUSP16 PAK3 PRKG1 CDC42 MAP2K6 MAP2K3 MAP3K3 TRAF6 CCM2 MAP3K12 MAPK11 RAC1 MAP2K4 SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) GSK3B KITLG FER JAK2 EPO STAT5A STAT1 STAT3 PDPK1 BAD PIK3CA MATK MAPK8 PTPRO PIK3C2B SPRED2 SPRED1 GRAP2 CRKL MAP4K1 MAPK3 STAP1 SH2B3 SH2B2 AKT1 EPOR TEC SNAI2 CBL SOCS1 MITF LYN RPS6KB1 SHC1 PTPN6 FOXO3 GRB10 HRAS GAB1 PTEN PTPN11 BCL2 DOK1 CREBBP MAP2K1 GRB2 MAP2K2 SOS1 KIT RAF1 PIK3R1 VAV1 GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network PTCH1 BMP4 FGF7 MAPK8 GPC3 FURIN MAPK9 SHH ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events VEGFD VEGFA ADAM2 ADAM15 ADAM12 ADAM8 PAOX NOS2 CSF2 SRC CSF2RA FN1 PXN VCAM1 ITGB1 SPP1 RAC1 ITGA9 TNC BCAR1 F13A1 SAT1 TGM2 KCNJ15 VEGFC DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining PRKDC DCLRE1C XRCC4 POLM PNKP LIG4 DNTT XRCC6 APTX XRCC5 APLF POLL NHEJ1 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) PTPN1 APC MET PLCG1 EGR1 RAP1B PDPK1 BAD PRKCZ PIK3CA JUN NCK2 AKT2 MLST8 PRKCI CDC42 MAPK8 SNAI1 MAPK1 ETS1 RAC1 CRKL MAPK3 RAPGEF1 MAP3K1 AKT1 INPPL1 RHOA MAP2K4 BCAR1 PAK1 WASL CBL INPP5D EIF4EBP1 EIF4E MTOR SH3KBP1 PAK2 RPTOR DEPTOR SRC AKT1S1 NUMB SHC1 ARHGEF4 PXN RAB5A RIN2 KPNB1 RAP1A EPS15 HRAS PAK4 RANBP9 NCK1 RANBP10 GAB1 MUC20 GAB2 PARD6A PTPN11 PTK2 SH3GL2 CDH1 CTNNA1 PTPRJ MAP2K1 GRB2 MAP2K2 SOS1 HGS CRK RAF1 PTPN2 HGF F2RL2 CTNNB1 PIK3R1 ARF6 EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway PAK1 WASL PTPN1 PLCG1 STAT1 STAT3 SRC PIK3CA SHC1 PTPN6 NRAS NCK2 HRAS NCK1 PIK3CB GAB1 PTPN11 PTK2 PIP5K1C KRAS RASA1 GRB2 SOS1 MAPK1 MAPK3 GSN GNAI3 GNAI1 EGFR TLN1 PIK3R1 EGF PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events GNAI2 ARHGDIA ROCK1 GNA13 PRKCD GNA14 GNA15 PIK3CA GNA11 GNAQ DNM1 PLCB2 PRKCB ARRB1 AKAP13 GRK3 PRKCA SNX1 SNX2 GNG2 VASP ROCK2 PRKCG TRPC6 F2R PLCB3 GNB1 ARHGEF1 PLCB1 ZYX DNM2 MYL2 GNAI3 GNAI1 PKN1 F2RL2 RHOA F2 PIK3R1 NOS3 GNAO1 GNAZ GNA12 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events ADAM12 TNFRSF13B LAMA1 LAMA3 PRKCD FN1 THBS1 MDK PRKCA ACTN1 ITGB1 PTK2 CXCR4 SDC4 TFPI FGF6 NUDT16L1 DNM2 RAC1 CXCL12 SDCBP CCL5 FZD7 GIPC1 ITGA5 FGF2 MMP9 RHOA F2 TNC PLG FGFR1 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway USP7 SMYD2 E4F1 GSK3B CSNK1D TTC5 CSNK1E HIPK2 CCNG1 PIN1 MDM4 CSNK1G2 CSNK1G1 RPL11 CSNK1A1 PRKCD YY1 HUWE1 MAPK9 KAT5 MDM2 CCNA2 RCHY1 MAPK8 CHEK1 ABL1 AKT1 EP300 PPP2CA KAT2B PRMT5 MAPK14 TRIM28 NEDD8 CREBBP RPL5 DYRK2 CSE1L SETD7 UBE2D1 CDK2 TP53AIP1 RASSF1 PPP1R13L CHEK2 KAT8 KMT5A ATM DAXX TP53 RPL23 ATR FBXO11 PPM1D SKP2 PTPA CSNK1G3 COP1 CDKN2A CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes PTPN1 DGKA SLC3A2 IKZF1 PTPRK BCE1 EGR2 CSF2 CXCL8 CTLA4 CREM GBP3 FASLG EGR1 EGR3 FOXP3 PPARG PTGS2 RNF128 PRKCQ JUNB JUN EGR4 GATA3 BATF3 CBLB POU2F1 NFATC3 NFATC2 NFATC1 ITCH FOS TBX21 E2F1 IL2 FOSL1 IL4 IL3 CASP3 CD40LG IFNG IL2RA CALM3 MAF IL5 CDK4 IRF4 TNF E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events CDH1 CTNNB1 JUP S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway GNAI2 PAK1 MAPK8 CDH5 MAPK1 MAPK14 RAC1 GNA13 MAPK3 GNAI3 GNA14 IRS1 GNAI1 GNA15 JUN GNA11 ELK1 GNAQ RHOA S1PR2 FOS GNAO1 GNAZ GNA12 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling GNAI2 AR CREB1 PLCG1 PELP1 GNRH1 SRC SHBG PIK3CA HRAS PLCB2 FOS PTK2 GNG2 CDC42 PLCB3 GNB1 MAP2K1 MAP2K2 PLCB1 MAPK1 RAC1 MAPK3 RAF1 GNAI3 GNAI1 AKT1 PLCG2 PIK3R1 GNAO1 GNAZ PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events CDC25C PLK3 CCNE1 CHEK2 TP53 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 GJA1 CCL2 CCND1 DMTF1 CXCL8 LAMA3 PLAUR FOSL2 IL6 TXLNG JUNB THBD BGLAP JUN HMOX1 LIF NFATC3 USF2 NFATC2 DCN NFATC1 MGP IVL ATF4 FOSL1 ITGB4 CCNA2 PLAU JUND COL1A2 SP1 EP300 MMP1 MMP2 MMP9 NOS3 CDKN2A ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway RAD9A YWHAB DCLRE1C XRCC4 CDC25C CTBP1 RBBP8 TRIM28 MDC1 ABRAXAS1 KAT5 RNF8 MDM2 SMC3 UIMC1 TP53BP1 SMC1A MRE11 TERF2 H2AX UBE2N BLM BID BRCA1 NBN ABL1 RAD50 TOP3A CHEK2 FANCD2 ATM RAD17 COP1 CDC25A HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha TNFRSF1A CYCS FASLG NFKB1 NFKBIA CASP9 CASP6 CASP8 CASP3 RIPK1 BCL2 CD247 MAP3K5 CASP7 FADD MAP2K7 nef BID TRAF1 MAPK8 CFLAR CASP2 FAS APAF1 BIRC3 TRADD CHUK BAG4 MAP3K14 DAXX CRADD TNF RELA TRAF2 ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling HMGB1 HSPD1 CD14 IKBKB IKBKG LY96 IRAK1 IRAK2 BGN IRAK4 TICAM1 TIRAP TLR1 VCAN SAA2 SFTPA1 TLR6 TLR4 CHUK S100A9 TLR3 S100A8 RHOA MYD88 TLR2 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events TGFB1 STAT4 IL12B IL12RB1 JAK2 STAT5A STAT1 STAT3 IL18 TYK2 IL6 GATA3 IL1B IL17A TBX21 IL2 IFNG IL6ST JAK1 EBI3 IL27 IL27RA IL12A TNF IL12RB2 STAT2 P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling YWHAE BCL2L11 BAD PRKCZ PIK3CA MAPK9 CASP9 IKBKB CASP3 IKBKG PRKCI TRAF6 SQSTM1 MAPK8 IRAK1 MAPK10 MAGED1 RAC1 BIRC2 NGFR AKT1 CHUK PSENEN RHOA MYD88 FURIN PSEN1 APH1A NCSTN PRDM4 APH1B SMPD2 RIPK2 NSMCE3 MMP3 CYCS OMG RHOC RHOB MAG ARHGDIA BEX3 MAGEH1 ZNF274 BEX1 ADAM17 RTN4 NDN LINGO1 SORT1 SHC1 E2F1 CASP6 PRKACB APP NGF APAF1 BIRC3 DIABLO MMP7 XIAP NTF4 NTF3 NTRK1 TP53 PLG PIK3R1 BDNF CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway PIP5K1B GSK3B CAV1 APC CUL3 LRP6 CSNK1G1 FZD5 RANBP3 WNT3A KLHL12 NKD2 DVL1 PPP2R5A DVL2 DVL3 AXIN1 CTNNB1 PI4K2A GSK3A FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway RUNX2 CBL CAMK2A STAT5B SPRY2 FGFR4 PLCG1 STAT1 FGFR3 PDPK1 PLAUR SRC PIK3CA SHC1 BGLAP JUN KLB FGF1 RPS6KA1 PAK4 NCAM1 FOS IL17RD GAB1 SSH1 FRS2 FGFR2 PTPN11 CTNND1 CDH1 PLAU GRB2 SPP1 SOS1 MAPK1 PTK2B CTTN MAPK3 SDC2 FGF23 AKT1 MMP9 FGFR1 PIK3R1 CDH2 FGF19 ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events BMP7 SMAD9 SMAD4 SMAD5 BMPR2 TLX2 FKBP1A ACVR1 AMHR2 SMAD1 AMH COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity CDK6 CCND1 KDM1A PELP1 UBE2I CASP8 PIAS1 TMPRSS2 KLK3 KLK2 PTK2B VAV3 GSN CARM1 AKT1 TGIF1 PIAS4 PIAS3 NCOA2 PAWR MED1 AR RANBP9 SRF HIP1 TGFB1I1 FHL2 UBE3A PRKDC RPS6KA3 NRIP1 BRCA1 CCND3 ZMIZ1 NKX3-1 APPL1 NCOA6 NCOA4 LATS2 XRCC6 CTDSP1 XRCC5 CTDSP2 MAK ZNF318 SNURF FKBP4 KDM3A UBA3 TMF1 PRDX1 HNRNPA1 CTNNB1 PATZ1 SVIL KDM4C PA2G4 TCF4 CMTM2 CDKN2A E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes CTNND1 VASP FYN CDH1 CTNNA1 JUP PLCG1 ZYX PIP5K1A RAC1 SRC PIK3CA AKT1 EGFR CTNNB1 RHOA PIK3R1 CASR AKT2 FMN1 AJUBA IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events CRP SOCS3 HSP90B1 TNFSF11 LBP A2M TIMP1 MCL1 JAK2 FGG PTPRE STAT1 STAT3 MAPK14 MITF CEBPB TYK2 PRKCD IL6 JUNB PIK3CA JUN HCK BCL2L1 FOXO1 FOS GAB1 GAB2 IRF1 PTPN11 PIAS1 IL6R MAP2K6 GRB2 SOS1 LMO4 MAPK11 RAC1 IL6ST MYC JAK1 AKT1 CEBPD MAP2K4 PIAS3 PIK3R1 VAV1 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 EFNA5 EPHA3 EPHA2 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway RAD9A YWHAB PPP2R1A CLSPN BTRC SMARCAL1 MCM7 CEP164 TIPIN CDC6 PPP2R2B FBXW11 TIMELESS MCM2 PLK1 CDC25C YWHAZ MDM2 CCNA2 BRCA2 NBN CHEK1 TOPBP1 ATRIP RFC5 RFC3 RFC4 CDK2 RFC2 RAD51 RPA1 HUS1 FANCD2 RPA2 ATR PPP2CA RAD17 RAD1 CDC25A DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin GSK3B CSNK1D APC CSNK1E LRP6 BTRC CSNK1A1 FZD5 CUL1 WNT3A SKP1 DVL1 DVL2 DVL3 AXIN1 CTNNB1 AXIN2 GSK3A IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway YWHAE PTPN1 PDPK1 BAD PRKCZ RACK1 PRKCD RPS6KB1 PRKD1 IRS1 YWHAZ PIK3CA SHC1 PXN IRS2 GRB10 NCK2 HRAS PTPN11 PTK2 IGF1R GRB2 SOS1 CRK CRKL RAF1 AKT1 BCAR1 PIK3R1 IGF1 CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin MAP2K7 CALM3 MAP2K3 MAP2K6 MAP2K1 CASP1 MAP2K2 MAPK1 IL18 MAPK3 cya ANTXR2 lef IL1B ANTXR1 DEFA1B NLRP1 MAP2K4 pagA TNF PGR VCAM1 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods PDE6B GUCY2F GNAT1 RPE65 PDE6A GRK1 CNGB1 RDH12 RGS9BP GNB1 RDH5 LRAT GNB5 RGS9 SLC24A1 GUCY2D PDE6G GNGT1 GUCA1B RHO GUCA1A SAG GUCA1C CNGA1 FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network GAS1 CCNB1 RB1 CCND1 CCNB2 PLK1 CDC25B NFATC3 GSK3A FOS ETV5 CDK1 LAMA4 CCNA2 ONECUT1 TGFA CREBBP FOXM1 AURKB BRCA2 CENPB MAP2K1 CENPA CKS1B NEK2 H2BC1 ESR1 XRCC1 CENPF HSPA1B MYC SP1 CDK4 CDK2 EP300 MMP2 CCNE1 CHEK2 BIRC5 SKP2 CDKN2A IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events GNAI2 CBL PLD1 CXCL8 PDPK1 LYN PIK3CG GNA14 PIK3R6 GNA15 FGR RAB5A HCK DNM1 PLCB2 PRKCB ARRB1 PRKCE PRKCA GNG2 PRKCG PLCB3 GNB1 PLCB1 CXCR1 AKT1 ARRB2 GRK2 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions THY1 FCGR2A FGG PLAT ICAM1 JAM3 PLAUR KNG1 VCAM1 CD40LG ITGAM C3 CCN1 ITGB2 ITGAL PLAU ITGAX ITGAD SPON2 ICAM2 ICAM3 ICAM4 F11R FGB FGA F10 GP1BA PROC TGFBI INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport INS RHOQ YWHAE VAMP2 GSK3B YWHAB INSR STXBP4 YWHAQ SFN YWHAG YWHAH PRKCZ YWHAZ AKT2 STX4 SLC2A4 TBC1D4 PRKCI CALM3 PPP1CC AKT1 ASIP PPP1R3A GYS1 LNPEP TRIP10 PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway YWHAE CSK PTPN1 YWHAB YWHAQ SFN PLCG1 YWHAG YWHAH PPP2R2B PRKCD YWHAZ JUN BRAF ELK1 NRAS FOS MAPK9 PRKCE KRAS JUND MYC VAV2 USP6NL WASL CBL SLA ACTN4 FYN RAB4A YES1 DOCK4 MYOCD ARAP1 STAT5B ACTA2 TAGLN NHERF2 PLA2G4A NHERF1 SIPA1 PIK3CG PIK3R6 RAB5A LCK ARHGAP35 PDGFRB MAP2K1 MAP2K2 DNM2 RAF1 PDGFB IQGAP1 PAG1 EPS8 PIK3R1 AFDN PIN1 JAK2 LRP1 STAT5A STAT1 STAT3 RAP1B SPHK1 PIK3CA S1PR1 NCK2 PIK3CB CYFIP2 MAP2K7 ITGB3 NCKAP1 WASF2 MAPK8 MAPK10 MAPK1 ITGAV ABL1 RAC1 CTTN MAPK3 ABI1 RAPGEF1 RHOA MAP2K4 KSR1 BCAR1 EIF2AK2 PPP2CA PAK1 PPP2R1A ARPC1B BRK1 BLK ARHGDIA ACTR3 ACTR2 LYN ARPC4 ARPC5 SRC BAIAP2 SHC1 ARPC2 FGR ARPC3 HCK RAP1A GRB10 HRAS NCK1 GAB1 SRF PTEN PRKCA PTPN11 DOK1 RPS6KA3 RASA1 GRB2 PTPRJ SOS1 CRK PTPN2 ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway ACVRL1 FKBP1A ACVR1 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway AFDN PTPRM RAP1B PVR CLDN1 NECTIN3 SRC NECTIN1 PIK3CA RAP1A PTK2 PIP5K1C ITGB3 CDC42 CDH1 NECTIN2 CTNNA1 PDGFRB CRK ITGAV RAC1 RAPGEF1 PDGFB F11R TLN1 IQGAP1 VAV2 CTNNB1 PIK3R1 FARP2 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway CSK PDPK1 NFKB1 NFKBIA PIK3CA JUN ELK1 NFATC1 FOS IKBKB FCGR2B IKBKG CALM3 TRAF6 MAPK8 MAPK1 ETS1 BTK RAC1 MAP4K1 MAPK3 MAP3K1 AKT1 SYK CHUK CAMK2G VAV2 DAPP1 PLCG2 BLNK INPP5D MAPK14 LYN PPP3CB CSNK2A1 PPP3CC SHC1 PTPN6 CARD11 BCL2A1 BCL10 POU2F2 MALT1 PPP3CA HRAS CD79B CD79A CD19 SH3BP5 PTEN CD72 IBTK PTPRC CD22 NFKBIB MAP3K7 DOK1 RASA1 MAP2K1 GRB2 SOS1 RAF1 PAG1 PIK3R1 RELA REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity TRIO DEF6 BCR ARHGEF2 CDKN1B ECT2 ARHGAP5 ARHGDIA ARAP1 ARHGEF11 ARHGEF28 AKAP13 ARHGAP8 ARHGDIG ARHGAP35 ARHGEF10L ARHGAP6 ARHGAP4 OPHN1 ARHGDIB SRGAP1 ARHGEF1 FARP1 ARHGEF10 ARHGEF12 ARHGEF17 PLEKHG6 ARHGEF18 MYO9B VAV3 NET1 OBSCN DLC1 ARHGEF3 ARHGEF25 ARHGEF15 ARHGEF5 VAV2 ARHGAP9 RHOA ABR MCF2L NGEF MCF2 ARAP3 VAV1 EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin botB RAB3GAP2 VAMP2 STX1A UNC13B CHRNA1 SNAP25 SYT1 STXBP1 botG botE botF RIMS1 botD botA NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway DNER ADAM10 NOTCH2 CCND1 NOTCH3 NOTCH1 KDM1A MYCBP MAML2 NOTCH4 MAML1 DTX1 DLL1 DLL3 DLL4 MARK2 RBPJ JAG2 JAG1 CUL1 CNTN6 SKP1 DLK1 YY1 RAB11A MIB1 MFAP5 NEURL1 MFAP2 RBBP8 CNTN1 DNM1 LNX1 SPEN NCOR2 IL4 CDKN1A MYC EP300 PSENEN FURIN APH1A NCSTN APH1B CBL ADAM12 BTRC NCOR1 FBXW7 HDAC1 CTBP1 NUMB GATA3 EPS15 ITCH PTCRA ENO1 SKP2 GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network GPC2 MDK IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 IL2RG CDK6 STAT5A ELF1 STAT5B FASLG FOXP3 PIK3CA SHC1 BCL2L1 PRF1 IL2 GAB2 IL4 LCK PTPN11 IL2RB BCL2 CCNA2 IL2RA CCND3 GRB2 SOS1 MYC JAK3 SP1 JAK1 CCND2 PIK3R1 LTA ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events ERBB2 JAK2 NRG2 STAT3 MTOR BAD SRC PRKACA PPP3CB PIK3CA SHC1 JUN NRG1 NRAS DOCK7 HRAS MAPK9 ERBB3 FOS CHRNE PIK3CB USP8 NFATC4 RNF41 NF2 PTPN11 KRAS CDC42 MAPK8 MAP2K1 GRB2 MAP2K2 MAPK10 SOS1 MAPK1 RAC1 MAPK3 RAF1 AKT1 CHRNA1 PIK3R1 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events GNAI2 CBL PPP2R1A DOCK2 CXCL8 PLD2 ELMO1 PDPK1 LYN PIK3CG GNA14 RAB11A PIK3R6 GNA15 FGR RAB5A HCK DNM1 PLCB2 PRKCB ARRB1 PRKCA CXCR2 RAC2 GNG2 VASP RAB7A PRKCG PLCB3 GNB1 PLCB1 AKT1 ARRB2 PPP2CA FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks FOXA1 FOXA3 FOXA2 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events SDC2 SDC1 SDC3 SDC4 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions VEGFA THY1 COL4A3 COL4A6 SDC1 FGG COL4A5 HMGB1 TGFBR2 PVR PLAUR SPHK1 FN1 THBS1 LAMB1 CCN1 LAMA4 ITGB3 ITGA2B KDR IBSP EDIL3 PDGFRB PLAU L1CAM SPP1 PECAM1 SDC4 CD47 LAMC1 FBN1 ITGAV VTN COL1A2 PDGFB F11R FGB FGA COL1A1 TNC TGFBI COL4A1 COL4A4 THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway F2 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events SOCS3 STAT5A STAT1 STAT3 PIK3CA JUN CISH NRAS FOS MAPK9 IL2 PRKCB PRKCE IFNG KRAS IL2RA MAPK8 MAPK1 MAPK11 IKZF3 PTK2B STAM2 SOCS2 MAPK3 STAM MYC JAK3 JAK1 SYK RHOA DOK2 IL2RG SOCS1 FYN STAT5B MAPK14 MAPKAPK2 IRS1 SHC1 IRS2 HRAS GAB2 LCK PTPN11 IL2RB BCL2 RASA1 MAP2K1 GRB2 MAP2K2 SOS1 RAF1 CDK2 PIK3R1 GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway GPC1 GPC3 GPC2 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway CSNK1E CHEK1 TIMELESS NONO NR1D1 NPAS2 PER2 DELEC1 PER1 CRY2 BHLHE40 CRY1 WDR5 BMAL1 CLOCK ATR IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events IL18RAP STAT4 IL12B IL12RB1 JAK2 B2M EOMES HLA-A STAT5A NOS2 STAT1 STAT3 IL18 FASLG TYK2 CD8B CD8A NFKB1 CD4 IL1B GZMB IL18R1 CD3G CD3D FOS TBX21 IL2 IL4 HLA-DRA CD247 IFNG RAB7A HLA-DRB1 IL2RA ATF2 MAP2K6 IL12A CCR5 SPHK2 IL1R1 IL12RB2 RELB HLX CCL4 RIPK2 CCL3 GADD45B IL2RG GZMA SOCS1 NFKB2 GADD45G STAT6 MAPK14 MTOR LCK IL2RB MAP2K3 CD3E RELA BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions MADCAM1 CCN1 SDC1 EDIL3 PLAU ITGB5 TGFBR1 ITGB8 ITGB7 ITGB6 FBN1 ITGA4 ITGAV PLAUR VTN FN1 VCAM1 INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis VEGFA COL5A2 COL6A1 COL4A3 COL4A6 SDC1 CDKN1B COL6A3 COL4A5 ROCK1 PIK3CA FN1 CASP8 ITGB3 ILK EDIL3 SPP1 MAPK1 PTK2B ITGAV RAC1 MAPK3 VAV3 AKT1 F11R RHOA BCAR1 CBL PIK3C2A ADGRA2 ANGPTL3 MFGE8 TGFBR2 PI4KA PI4KB SRC RPS6KB1 IRS1 PXN HSP90AA1 PTPN11 PTK2 IGF1R KDR COL11A1 COL11A2 VTN COL1A2 CSF1R TLN1 FGF2 VCL CSF1 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 PIK3R1 COL6A2 COL4A4 IGF1 COL7A1 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III KAT2B BAX SIRT7 SIRT1 MYOD1 SIRT2 ACSS2 HOXA10 SIRT3 TUBA1B ACSS1 MEF2D H4C9 tat H1-4 TUBB2A FOXO4 FOXO3 FOXO1 HDAC4 FHL2 CREBBP CDKN1A PPARGC1A XRCC6 EP300 TP53 RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling KAT2B RARA RARB MAPK14 HDAC3 HDAC1 PRKACA NCOA3 CCNH CDK7 RBP1 MNAT1 CDK1 NCOR2 PRKCA PRKCG NRIP1 CREBBP MAPK8 RXRB VDR RXRA MAPK1 RXRG MAPK3 AKT1 EP300 NCOA1 NCOA2 RARG HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha ELOB HIF1AN VHL ELOC EGLN1 HIF1A EGLN3 COPS5 RACK1 EGLN2 NAA10 CUL2 TP53 HIF3A HSP90AA1 RBX1 ARNT OS9 CDKN2A FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network INS AR CDKN1B COL18A1 APOB CEBPB DSCAM JUN NCOA3 AP1B1 POU2F1 FOS TFF1 SERPINA1 SFTPA2 PRDM15 C4BPB CYP2C18 SFTPD FOXA1 GCG KLK3 NR2F2 FOXA3 NRIP1 PISD FOXA2 BRCA1 CREBBP NFIA NFIB NDUFV3 NKX3-1 NFIC ATP5PF SCGB1A1 XBP1 ESR1 VTN SP1 SFTPA1 SOD1 EP300 SHH NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway CAMK2A YES1 TAB2 TAB1 ROCK1 CSNK1A1 PPARG PRKCZ DVL1 DVL2 DVL3 NFATC2 MAPK9 MAP3K7 CDC42 MAPK8 MAPK10 CHD7 FLNA CTHRC1 SETDB1 DAAM1 RAC1 FZD2 FZD5 FZD7 FZD6 NLK WNT5A RHOA ARRB2 ROR2 PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling GNAI2 GNA13 PELP1 HBEGF SRC GNA14 GNA15 PIK3CA SHC1 GNA11 GNAQ NRAS HRAS PLCB2 GNG2 KRAS ROCK2 IGF1R PLCB3 GNB1 GRB2 PLCB1 SOS1 MSN MAPK11 ESR1 GNAL STRN ESR2 GNAI3 GNAI1 AKT1 MMP2 MMP9 RHOA BCAR1 PIK3R1 NOS3 GNAO1 GNAZ IGF1 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription MT-CO2 YWHAE TNIK TCF7 APC YWHAB ADCY7 CACNA1G IGF2BP1 CCND1 TBL1X YWHAQ CDX4 CDX1 SFN KCNIP4 KLF4 CXCL8 YWHAG SMARCA4 YWHAH BCL9 TCF7L2 SP5 NEUROG1 MYF5 CUL1 SKP1 YWHAZ JUN CAMK4 TLE1 XPO1 ID2 RUVBL2 INCENP VCAN MYC EP300 MMP2 SNAI2 MMP9 NCOA2 AR BTRC TBXT MITF HDAC2 TCF7L1 HDAC1 CTBP1 HBP1 DVL3 AXIN2 TERT CCN1 CDH1 ZCCHC12 CHD8 CBY1 TRRAP FGF4 MED12 SALL4 LEF1 CCND2 PITX2 CTNNB1 MYOG TLE4 TLE2 KRT1 CTNNBIP1 TCF4 TLE5 DKK4 DKK1 MDFIC TBL1XR1 CDKN2A EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway SOCS3 CBL INPP5D JAK2 EPO STAT5A STAT5B PLCG1 STAT1 MAPK14 NFKB1 LYN SHC1 PTPN6 IRS2 BCL2L1 RAP1A HRAS GAB1 PTPN11 BCL2 MAPK8 GRB2 SOS1 BTK CRKL RAPGEF1 SH2B3 EPOR TEC VAV2 PLCG2 PIK3R1 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway GADD45B GADD45G TAB2 TAB1 CAMK2B MAPK14 MAP3K6 MAP3K4 TAOK3 TAOK1 TAOK2 MAP3K10 MAP3K7 MAP3K5 CALM3 MAP2K6 MAP2K3 MAP3K3 TRAF6 CCM2 MAPK11 GADD45A RAC1 MAP3K1 ATM TXN TRAF2 C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway SUPT3H SUPT7L GSK3B PIN1 KAT2A TAF9 PAK2 FBXW7 MAX TAF12 HBP1 PPP2R5A TAF10 PML RUVBL1 KAT5 RUVBL2 ZBTB17 MYC TRRAP AXIN1 ACTL6A PPP2CA SKP2 CDKN2A S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway VEGFA GNAI2 KDR PDGFRB MAPK1 PLCG1 RAC1 ABCC1 PTGS2 MAPK3 SPHK1 PDGFB GNAI3 GNAI1 RHOA S1PR1 PLCB2 GNAO1 GNAZ GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network TGFB1 VEGFA TGFB3 FYN YES1 FLT1 BLK TGFBR1 TGFBR2 LAMA1 LYN SRC NRG1 FGR HCK SERPINC1 SLIT2 PRNP PLA2G2A CRIPTO APP LCK SMAD2 GPC1 FGF2 FGFR1 ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins GNAI2 ADCY7 JAK2 EDN1 PRKCQ PRKCD GNA14 GNA15 JUN GNA11 GNAQ FOS EDNRA PRKCB CYSLTR1 PRKCE EDNRB CYSLTR2 EDN2 PRKCH EDN3 ADCY9 ADCY4 ADCY3 ADCY2 CDC42 ADCY1 MAPK8 ADCY8 ADCY6 ADCY5 MAPK1 PTK2B RAC1 MAPK3 AKT1 RHOA BCAR1 PLA2G4A MAPK14 SRC HRAS PLCB2 SLC9A1 PRKCA PRKCG TRPC6 PLCB3 MAP2K1 MAP2K2 PLCB1 CRK GNAL RAF1 COL1A2 SLC9A3 GNAI3 GNAI1 MMP1 COL3A1 GNAO1 GNAZ GNA12 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network VEGFD VEGFA KDR FLT1 NRP1 NRP2 FLT4 VEGFB VEGFC PGF NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte WASL FYN PLCG1 BAD PRKCZ PIK3CA JUN NCK2 MAPK9 NCK1 PIK3CB PARD6A PRKCI TRPC6 MAPK8 GRB2 MAPK10 TJP1 RAC1 KIRREL1 CD2AP NPHS1 AKT1 NPHS2 F2RL2 MAP2K4 PIK3R1 ARRB2 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events GNAI2 GSK3B ADCY7 PLCG1 CXCL8 NFKB1 NFKBIA PRKCD PRKD1 GNA14 GNA15 TRIP6 JUN GNA11 GNAQ FOS PIK3CB PRKCE CASP3 ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY6 ADCY5 TIAM1 PTK2B RAC1 AKT1 ADRA1B MMP2 LPAR1 MMP9 LPAR2 RHOA LPAR3 LPAR4 BCAR1 NHERF2 PLD2 GNA13 HBEGF LYN SRC PXN MAPT HRAS GAB1 PTK2 GNG2 PLCB3 GNB1 ARHGEF1 CRK GNAI3 GNAI1 EGFR PIK3R1 GNAO1 GNAZ GNA12 RELA BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions VEGFA COL5A2 COL6A1 COL4A3 COL4A6 COL6A3 FGG COL4A5 ITGA3 LAMA1 PLAUR LAMA3 FN1 LAMA2 LAMB3 ITGB1 LAMB2 LAMB1 LAMC2 LAMA4 PLAU SPP1 LAMC1 FBN1 ITGA4 ITGAV ITGA2 ITGA1 ITGA10 ITGA11 ITGA8 ITGA7 ITGA6 FGB ITGA5 FGA ITGA9 NPNT TNC NID1 TGFBI F13A1 CSPG4 TGM2 COL18A1 IGSF8 CD81 THBS2 THBS1 MDK CD14 JAM2 VCAM1 LAMA5 COL11A1 COL11A2 VTN COL1A2 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 COL6A2 COL4A4 COL7A1 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling VLDLR TGFB1 PDGFD CTSG MMP3 MMP12 MMP13 CTRC LRP1 FGG GPLD1 ITGA3 DOCK1 PLAUR SRC FN1 ITGB1 ITGAM ITGB3 ITGB2 PDGFRB PLAU ITGB5 SERPINE1 CRK ITGAV RAC1 VTN EGFR FGB HGF ITGA5 FGA MMP9 PLG ELANE NCL BCAR1 FPR1 KLK4 FPR3 FPR2 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression CDKN1B CCND1 LGALS1 ID2 ITGB1 ITGB4 DDIT3 CDKN1A CFLAR SPI1 GADD45A MYC EP300 ITGA6 ERBB2 RBL1 GFI1 CLU CREB1 FTH1 HMGCS2 TBP DNTT SLC11A1 DNMT3A TSC2 SFRP1 TMEFF2 CSDE1 HDAC3 HDAC1 TMEM126A S100A7 MAX ALDH9A1 IRF8 NDRG2 NDRG1 FOXO3 ZFP36L1 NFYA NFYB NFYC GTF2H2 SFXN3 MXD4 TJP2 BCL2 SMAD2 ZBTB17 SMAD4 BRCA1 PDGFRB CDKN2B SMAD3 COL1A2 CCL5 SP1 CEBPA CEBPD WNT5A DKK1 PTPA ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network ERBB4 ERBB2 TGFA NRG2 EREG BTC NRG3 NRG4 HBEGF EGFR NRG1 ERBB3 HSP90AA1 EGF AREG SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II HDAC11 YWHAE YWHAB TUBA1B GATA1 HDAC5 HDAC3 BCL6 GATA2 HDAC9 TUBB2A CAMK4 HDAC6 HDAC7 RANBP2 HDAC4 XPO1 SRF HSP90AA1 UBE2I SUMO1 NCOR2 RANGAP1 RFXANK RAN BCOR GNG2 ANKRA2 GNB1 ESR1 NR3C1 MEF2C GRK2 HDAC10 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling YWHAE CAMK2A TAB2 TAB1 CCN2 PDPK1 PML FKBP1A NEDD4L AXIN1 EIF2A ARRB2 PPP2CA TGFB1 TGFB3 CAV1 YAP1 TGFBR1 TGFBR2 PPP1CA RPS6KB1 WWP1 SHC1 ITCH SMURF1 PARD6A MAP3K7 SMAD2 ZFYVE9 PPP2R2A DACT2 SMAD4 RNF111 TGFBR3 ZFYVE16 SMAD3 GRB2 STRAP SOS1 PPP1R15A TGFBRAP1 PPP2CB SMAD7 SPTBN1 SMURF2 DAB2 OCLN BAMBI DYNLRB1 XIAP CTNNB1 DAXX ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions CDH1 ITGAE ITGB7 JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway MAP3K7 MAPK8 LAT CRK GRAP2 MAP4K1 CRKL MAP3K1 DBNL JUN MAP3K8 MAP2K4 LCP2 PRKCB ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes YWHAE GSK3B YWHAB YWHAQ SFN YWHAG CSNK1A1 YWHAH AKAP5 CABIN1 PRKCQ BAD CHP1 PRKCD PRKCZ PRKACA YWHAZ CAMK4 MAP3K8 NFATC3 NFATC2 NFATC1 MAPK9 XPO1 PRKCB PRKCE FKBP1A CASP3 RCAN1 RAN PRKCH RCAN2 CALM3 MAPK8 MAPK3 MAP3K1 EP300 BAX NR4A1 MAPK14 MEF2D CSNK2A1 BCL2L1 KPNB1 PIM1 PRKCA BCL2 PRKCG CREBBP KPNA2 NUP214 FKBP8 TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells CSK TRPV6 PLCG1 LAT PDPK1 PRKCQ RASGRP2 CD4 RASGRP1 ITK CD86 CD80 MAP3K8 NRAS CD3G CD3D LCP2 PRKCB IKBKB PRKCE CD28 HLA-DRA CD247 IKBKG KRAS HLA-DRB1 CDC42 TRAF6 GRAP2 MAP4K1 AKT1 CHUK MAP3K14 ZAP70 CBL FYN INPP5D SHC1 PTPN6 CARD11 BCL10 RAP1A MALT1 HRAS NCK1 PTEN GAB2 PRKCA LCK PTPRC PTPN11 GRB2 SOS1 FLNA DBNL SLA2 PAG1 RASSF5 STIM1 ORAI1 WAS CD3E STK39 SH3BP2 FYB1 VAV1 VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals VEGFA CBL CAV1 FLT1 PLCG1 PDPK1 HIF1A PRKACA PIK3CA NCK1 HSP90AA1 PRKCB PRKCA PTPN11 CALM3 RASA1 SHC2 MAPK1 NRP1 NRP2 VEGFB MAPK3 PGF CD2AP AKT1 PIK3R1 NOS3 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events SHC1 EGFR EDN1 GRB2 SOS1 HRAS EDNRA EGF MTOR HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins GLI1 GNAI2 GLI3 SAP30 GSK3B STK36 CSNK1D KIF3A CSNK1E RAB23 SUFU SPOP BTRC MTSS1 CSNK1G2 IFT88 CSNK1G1 CSNK1A1 FBXW11 HDAC2 HDAC1 PRKCD PRKACA LGALS3 RBBP4 XPO1 SAP18 RBBP7 GNG2 PIAS1 FOXA2 CREBBP GNB1 MAP2K1 SIN3B SIN3A GNAI3 GNAI1 AKT1 PTCH1 GLI2 SHH GNAO1 GNAZ ARRB2 SMO IFT172 CSNK1G3 INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway INS RHOQ CBL PTPN1 CAV1 INSR INPP5D SGK1 EIF4EBP1 SORBS1 PDPK1 PRKCZ RPS6KB1 IRS1 PIK3CA SHC1 FOXO3 GRB10 NCK2 HRAS NCK1 AKT2 PARD6A PTPN11 DOK1 PRKCI PTPRA RASA1 GRB2 EXOC7 SOS1 CRK RAPGEF1 SH2B2 EXOC4 AKT1 EXOC3 F2RL2 GRB14 EXOC6 EXOC5 EXOC2 PIK3R1 EXOC1 TRIP10 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network PDGFRA PDGFD PDGFB PDGFA PDGFRB PDGFC EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling PAK1 PTK2 CBL ARHGAP35 GRB2 ACP1 TIAM1 RAC1 VAV3 SRC PIK3CA SHC1 INPPL1 VAV2 RHOA EFNA1 BCAR1 PIK3R1 EPHA2 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling YWHAE YWHAB YWHAQ SFN YWHAG YWHAH EGR1 PDPK1 BAD PRKCD PRKCZ YWHAZ JUN BRAF ELK1 NRAS CAPN2 FOS MAPK9 DUSP1 KRAS RIN1 CALM3 ATF2 PEBP1 AKT1 VAV2 MEF2C ATF1 USP6NL WASL RPS6KA4 RPS6KA5 CREB1 MTOR RAB5A BCL2L1 RPS6 RALA PPP2R2A MAP2K1 MAP2K2 RAF1 EGFR IQGAP1 EPS8 PIK3R1 CHN2 EGF STAT1 STAT3 ZFP36 MYL11 RALGDS MAP2K5 PPP5C DIAPH3 ARF4 DUSP6 PIK3CA MAPK7 MAP3K2 MAPKAP1 PIK3CB MLST8 RICTOR CYFIP2 NCKAP1 CDC42 WASF2 MAPK8 MAPK1 RAC1 MAPK3 ABI1 MAP3K1 MAP2K4 KSR1 PPP2CA SMAD1 PPP2R1A ARPC1B BRK1 ACTR3 PLD1 ACTR2 PLD2 ARPC4 ARPC5 SRC BAIAP2 ARPC2 ARPC3 HRAS GAB1 SRF SLC9A1 PRKCA RPS6KA3 GRB2 SOS1 SH2D2A F2RL2 LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development VLDLR YWHAE NUDC MAP1B CSNK2A1 PLA2G7 LRP8 RELN KATNA1 NDEL1 DYNC1H1 CLIP1 DAB1 DCX PAFAH1B3 PAFAH1B2 CDK5R2 CDK5R1 PAFAH1B1 DYNLT1 CALM3 CDC42 ABL1 RAC1 LRPAP1 PPP2R5D IQGAP1 RHOA CDK5 SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL ITGB1 RABGGTB CCNA2 RHOC RABGGTA PTP4A1 CDKN1A PTP4A2 PTP4A3 ATF5 ROCK1 MAPK1 EGR1 ITGA1 AGT TUBA1B RAC1 MAPK3 SRC CDK2 CCNE1 RHOA BCAR1 EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling FYN YES1 BLK EFNB2 EFNB1 LYN SRC EPHB2 EPHB1 PIK3CA EPHB4 FGR HCK DNM1 NCK2 LCK PTPN13 MAP3K7 ITGB3 ITGA2B MAPK8 RGS3 TIAM1 RAC1 MAP2K4 PIK3R1 VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium VEGFD CREB1 MAPK14 PIK3CA SHC1 FN1 RPS6KA1 ITGB1 GRB2 SOS1 MAPK1 MAPK11 CRK ITGA4 FLT4 ITGA2 ITGA1 MAPK3 COL1A2 AKT1 ITGA5 COL1A1 MAP2K4 PIK3R1 VEGFC ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events ADAP1 MET SRC GNA14 GNA15 PXN GNA11 GNAQ NCK1 ARRB1 ADRB2 ITGB3 ITGA2B KIF13B FBXO8 TSHR LHCGR USP6 IQSEC1 ARAP2 ACAP1 IPCEF1 GULP1 ACAP2 AGTR1 EGFR HGF EFNA1 CYTH3 CYTH2 GIT1 ARF6 ARRB2 EGF EPHA2 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network RB1 PIN1 CDK6 SFN ADA BCL2L11 JAG2 GATA1 RACK1 HEY2 PML KAT5 PLPP1 MDM2 CCNA2 RCHY1 CDKN1A BRCA2 SERPINE1 CHEK1 MAPK11 FAS NEDD4L ABL1 MYC JAK1 IL1RAP EP300 IL4R BBC3 TUBA1A PEA15 FLOT2 RNF43 S100A2 AEN UBE4B CCNE2 NDUFS2 HAGH PFDN5 FBXO45 AFP CCNB1 PLK3 YAP1 GRAMD4 HSF1 BAX CLCA2 BAK1 WWOX BUB3 DEDD BUB1 GDF15 TP63 SIRT1 NSG1 TP53I3 MAPK14 WT1 TP73 DCP1B PLK1 FOXO3 ITCH FASN PRKACB CDK1 SERPINA1 CASP2 SP1 BIN1 CDK2 TP53AIP1 RAD51 NTRK1 RELA CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events GNAI2 MAPK14 MTOR CXCL13 PDPK1 CXCR3 CXCL10 SRC CXCL11 PIK3CA PF4 NRAS DNM1 HRAS MAPKAP1 PIK3CB ARRB1 MLST8 RICTOR GNG2 KRAS MAP2K6 MAP2K3 GNB1 MAP2K1 MAP2K2 MAPK1 MAPK11 MAPK3 RAF1 GNAI3 GNAI1 AKT1 CXCL9 PIK3R1 GNAO1 GNAZ CCL11 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events INPP5D JAK2 STAT5A STAT5B YWHAG ID1 CEBPB HDAC1 PRKACA PRKACG YWHAZ PIK3CA SHC1 OSM SRP9 CISH CNKSR1 IL3RA BCL2L1 CSF2RB PRKACB GAB2 PIM1 IL3 PTPN11 GRB2 PIK3R1 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling GNAI2 ROCK1 ICAM1 PRKCQ PRKCD PRKCZ PRKACA GNA14 RAB11A GNA15 GNA11 GNAQ DNM1 PRKCB PRKCE PRKCH PRKG1 MAPK11 RAC1 SELE AKT1 SYK RHOA ARRB2 TGM2 GRK2 FYN YES1 BLK NHERF1 MAPK14 GNA13 LYN PIK3CG SRC PIK3R6 FGR HCK PTGDR PTGIR PLCB2 TBXA2R PRKCA LCK GRK3 VCAM1 ARR3 GNG2 PRKCG GNB1 ARHGEF1 GNB5 EGFR NOS3 EGF GNA12 A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling YWHAE MST1 YWHAB ERBB2 YWHAQ MST1R SFN MET YWHAG YWHAH LAMA1 LAMA3 RPS6KB1 YWHAZ PIK3CA SHC1 IL1A HRAS COL17A1 ERBB3 PMP22 CD9 LAMA2 PRKCA LAMB3 ITGB1 LAMB2 LAMB1 ITGB4 LAMC2 CASP7 LAMA4 CDH1 GRB2 RXRB RXRA LAMC1 LAMA5 RXRG RAC1 AKT1 EGFR ITGA6 PIK3R1 EGF MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway YWHAE YWHAB SGK1 YWHAQ SFN YWHAG YWHAH PDPK1 YY1 YWHAZ BRAF PML NRAS MAPKAP1 CLIP1 IKBKB MLST8 RICTOR KRAS PPARGC1A MAPK1 MAPK3 AKT1 SREBF1 CYCS BTRC EIF4EBP1 EIF4E PLD1 PLD2 FBXW11 TSC2 MTOR RPTOR DEPTOR RPS6KB1 IRS1 AKT1S1 EEF2K RPS6KA1 HRAS PRR5 RB1CC1 TSC1 PRKCA ATG13 RRAGA RRAGC RRAGB DDIT4 RRAGD ULK2 ULK1 MAP2K1 RRN3 MAP2K2 POLDIP3 EIF4B BNIP3 EEF2 RHEB PDCD4 RAF1 EIF4A1 CDK2 CCNE1 ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway CHUK NFKB2 BTRC MAP3K14 RELB NFKB1 DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors TNFRSF10C TNFRSF10B TNFRSF10A APC TNFRSF10D TADA2B MCL1 RGCC JMY TAF9 BCL2L2 BTG2 SFN PPP1R13B TRIAP1 MET SMARCA4 CX3CL1 AIFM2 DGCR8 ZNF385A GPX1 PRMT1 PMAIP1 DDB2 RNF144B E2F3 RRM2B JUN IRF5 TYRP1 HTT PML RPS27L PPM1J NLRC4 TP53INP1 PMS2 E2F2 DROSHA TIGAR DUSP5 ARID3A EDN2 MLH1 DUSP1 CEBPZ SERPINB5 TGFA RCHY1 CDKN1A SERPINE1 GADD45A HSPA1B CARM1 EP300 SNAI2 EPHA2 KAT2A TFDP1 PERP ATF3 BDKRB2 TSC2 HDAC2 IGFBP3 BCL6 NDRG1 BCL2L1 BCL2A1 NFYA NFYB NFYC E2F1 CASP6 BCL2 PIDD1 CREBBP CASP1 VDR APAF1 SP1 CSE1L EGFR DKK1 COP1 RB1 CCNG1 MAP4K4 LIF MDM2 CASP10 FOXA1 BID SPP1 FAS VCAN BBC3 MMP2 CTSD S100A2 CCNB1 PLK3 CAV1 AFP BAX BAK1 GDF15 TP63 TP53I3 COL18A1 CD82 TP73 PTEN PCNA DDIT4 POU4F1 CCNK STEAP3 PRDM1 POU4F2 PYCARD TRRAP SESN1 FDXR BNIP3L HGF TAP1 PRKAB1 HIC1 MSH2 TP53 DDX5 PCBP4 TP53BP2 SCN3B BCL2L14 SH2D1A LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events ADCY7 ADCY9 ADCY4 ADCY3 ADCY2 RPS6KA5 ADCY1 ADCY8 CREB1 ADCY6 ADCY5 GNAL PRKACA LPAR4 PRKCE POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly PTPN1 MMP3 FYN ADAM10 MET GNA13 RET SRC PTPN6 RAB5A RIN2 HRAS GFRA1 SNX1 CASP3 CTNND1 ROBO1 RAB7A SLIT1 IGF1R DSP GDNF IGF2 CDC42 CDH1 CREBBP CABLES1 CTNNA1 ZBTB33 JUP MEP1B CBLL1 HGS TIAM1 DNM2 ABL1 RAC1 NME1 MMP7 EGFR IQGAP1 CTNNB1 NTRK2 CDH2 BDNF ARF6 EGF GNA12 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling PAK1 FZR1 GSK3B ARHGEF7 NFKBIA PRKACA CDC25B TPX2 NDEL1 MDM2 RAN CKAP5 BRCA1 AURKB RASA1 CENPA OAZ1 TACC3 DLGAP5 TDRD7 GADD45A CPEB1 AURKAIP1 AKT1 PPP2R5D AURKA TP53 BIRC5 GIT1 TACC1 AJUBA CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling STAT5A MAPK14 NFKB1 NFKBIA PIK3CG PIK3R6 PIK3CA JUN CBLB BCL2L1 MAPK9 PIK3CB IL4 CD40LG TRAF1 MAPK8 TRAF6 MAPK10 MAPK11 BIRC2 CD40 TNFAIP3 MYC JAK3 BIRC3 C4BPA MAP3K1 FCAMR AKT1 TRAF3 TDP2 MAP3K14 MAP2K4 PIK3R1 RELA TRAF2 VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network NEDD8 C3 SMARCA4 SMARCE1 NR0B1 NR0B2 ESR2 UBA3 NCOA3 NCOA1 SMARCB1 UBE2M DDX54 ZNF14 NCOA2 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases AURKC AURKB AURKA LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events STRADA YWHAE STK11IP GSK3B STRADB YWHAB ETV4 STK26 SIK3 SIK1 YWHAQ SIK2 CREB1 SFN YWHAG YWHAH MARK2 TSC2 MTOR RPTOR PRKACA YWHAZ AKT1S1 MAPT HSP90AA1 MLST8 TSC1 SMAD4 CDC37 ESR1 EZR MYC BRSK1 CTSD CRTC2 BRSK2 SMARCD3 TP53 CAB39 PSEN2 STK11 MAP2 MARK4 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway EFNB1 EPHB2 EPHB1 EPHB4 EPHB3 EFNB2 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway RPS6KA5 RUSC1 CREB1 MAPK14 EGR1 RAP1B MAP2K5 PRKCD MAPKAPK2 TRPV1 MAPK7 MAP3K2 BRAF ELK1 NRAS RAP1A RPS6KA1 HRAS FOS SRF KRAS CDK5R1 MAP2K6 MAP2K3 MAP2K1 MAPK1 MAPK3 RAF1 RIT1 RIT2 EHD4 NTF3 CDK5 MEF2C TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway SMPD2 TNFRSF1A TNIK CAV1 MADD NSMAF TAB2 TAB1 NRK RFFL STAT1 MAP4K5 MAP4K3 ADAM17 MAP4K2 TNFRSF1B NFKB1 CYLD PRKCZ RACK1 MAP4K4 SMPD1 IKBKB CASP8 RIPK1 IKBKG MAP3K7 MAP3K5 FADD MAP2K7 PRKCI MAP2K3 MAP3K3 TRAF1 SQSTM1 BIRC2 TNFAIP3 BIRC3 TRADD MAP3K1 CHUK BAG4 TNF TXN RELA TRAF2 FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks INS AFP CREB1 CEBPB G6PC1 ACADVL ALAS1 DLK1 TAT SLC2A2 TTR UCP2 NKX2-1 ACADM PCK1 HADH IGFBP1 CPT1A PKLR HMGCS1 KCNJ11 ABCC8 FOXF1 PDX1 NF1 APOA1 FOXA1 HNF1A CPT1C FOXA3 CPT1B FOXA2 GCK BDH1 ALB ALDOB NR3C1 SP1 CEBPA HNF4A TFRC AKT1 CEBPD F2 CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events GSK3B APC ARHGEF7 ARHGEF6 RASGRF1 PRKCZ DIAPH3 PIK3CA JUN BRAF MAPK9 PRKCE MAP2K7 ATF2 CDC42 MAP2K6 MAPK8 ENAH MAPK1 TIAM1 DLG1 RAC1 MAPK3 MAP3K1 VAV2 MAP2K4 BCAR1 PAK1 WASL CBL ARPC1B YES1 ARHGDIA ACTR3 ACTR2 PLD1 MAPK14 IQGAP3 MTOR PAK2 ARPC4 SRC ARPC5 RPS6KB1 BAIAP2 ARPC2 ARPC3 HRAS PAK4 MAP3K11 PARD6A CFL1 CDH1 MAP2K3 CTNNA1 LIMK2 LIMK1 EXOC7 PAX6 HES5 SEPTIN2 TNK2 CDC42BPA RAF1 MYL2 F2RL2 IQGAP1 CTNNB1 EPS8 PIK3R1 CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events GNAI2 CSK JAK2 STAT5A RALB STAT1 STAT3 RAP1B PDPK1 BAD RACK1 PRKCZ CD4 PIK3CA DNM1 CD3G CD3D MAPKAP1 PIK3CB MLST8 RICTOR HLA-DRA CD247 CXCR4 HLA-DRB1 CDC42 PTK2B RAC1 AKT1 MMP9 RHOA BCAR1 ARRB2 GRK2 STAT2 PAK1 FYN RHOC INPP5D YES1 RHOB BLK STAT5B MTOR GNA13 LYN PIK3CG SRC PIK3R6 PTPN6 FGR PXN HCK FOXO1 PLCB2 ITCH SSH1 LCK PTPRC ARR3 CFL1 PTPN11 PTK2 GNG2 PLCB3 GNB1 LIMK1 PLCB1 HGS CRK CXCL12 RGS1 VPS4B VPS4A GNAI3 GRK6 GNAI1 UBQLN1 PAG1 PIK3R1 CD3E GNAO1 GNAZ VAV1 P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases YWHAE YWHAB HSPB1 YWHAQ CREB1 SFN MAPK11 YWHAG MAPK14 YWHAH TSC2 RAF1 MAPKAPK3 MAPKAPK2 YWHAZ ETV1 CDC25B TCF3 LSP1 TH SRF PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling GSK3B APC ADAM10 NOTCH1 CCND1 BTRC TAB1 DTX1 PPARD DLL1 CSNK1A1 RBPJ FBXW11 NEDD4 HDAC1 CTBP1 DVL1 CSNK2A1 JUN TLE1 FOS MAP3K7 HNF1A CREBBP LRP6 WIF1 MAPK1 FZD1 MAPK3 MYC PPP2R5D NKD1 PSENEN AXIN1 CTNNB1 NLK FRAT1 DKK2 WNT1 PSEN1 TLE5 APH1A KREMEN2 NCSTN DKK1 APH1B VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms NQO1 TFAP2C SSRP1 DHRS3 YWHAQ ITGA3 ADA JAG1 PRKCD PMAIP1 PML IKBKB MDM2 ITGB4 SERPINB5 CABLES1 CDKN1A FAS GADD45A ABL1 EP300 CHUK BBC3 FLOT2 S100A2 SMARCD3 AEN SHH BAX CLCA2 BTRC MFGE8 GDF15 TP63 EGR2 PERP TP53I3 GPX2 PLK1 IGFBP3 WWP1 HBP1 ITCH VDR SP1 FDXR OGG1 NOC2L DST DICER1 TRAF4 SPATA18 EVPL CDKN2A IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway CBL CAMK2D CAMK2A SOCS1 PTGES2 IRF9 JAK2 STAT1 DAPK1 STAT3 CAMK2B CEBPB RAP1B MTOR PRKCD PIK3CA IL1B RAP1A MAP3K11 IRF1 PTPN11 PIAS1 IFNG CALM3 CREBBP CASP1 MAP2K1 MAPK1 IFNGR1 SMAD7 CRKL MAPK3 RAPGEF1 PTPN2 JAK1 MAP3K1 AKT1 EP300 CAMK2G PIAS4 PIK3R1 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway KDELR1 GOSR2 USO1 GBF1 CLTB AP2A1 PIP5K1A ARFGAP1 PLD2 GGA3 ARFIP2 RAC1 AP2M1 ARF1 CD4 COPA CLTA CYTH2 ASAP1 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events TAB2 TAB1 NFKB1 IL1RN PRKCZ ERC1 TICAM2 IL1R2 PIK3CA JUN IRAK3 TOLLIP IL1B UBE2V1 IL1A IKBKB IKBKG MAP3K7 PRKCI UBE2N MAP2K6 MAP3K3 MAPK8 TRAF6 SQSTM1 IRAK1 CASP1 IRAK4 IL1RAP CHUK MYD88 PIK3R1 IL1R1 RELA GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network GSK3B FGG SGK1 STAT5A SFN STAT1 CSF2 CXCL8 ICAM1 SMARCA4 YWHAH EGR1 NFKB1 PPP5C PRKACA IL6 BGLAP JUN POU2F1 VIPR1 SUMO2 KMT5B NFATC1 POU1F1 FOS MAPK9 SMARCC2 TBX21 IL2 IL13 FKBP5 SMARCD1 IRF1 TSG101 IL4 MDM2 NR1I3 SMARCC1 CGA PCK2 IFNG PBX1 CDK5R1 KRT17 CDKN1A MAPK8 MAPK10 SPI1 MAPK1 MAPK11 NR3C1 SELE MAPK3 AKT1 EP300 NCOA1 NCOA2 CDK5 POMC AFP BAX NR4A1 CREB1 STAT5B TBP MAPK14 HDAC2 HDAC1 PRKACG GATA3 KRT5 HSP90AA1 KRT14 PRKACB CREBBP IL5 FKBP4 MMP1 PRL CSN2 TP53 RELA INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 CBL ARHGEF7 LRIG1 SPRY2 ITSN1 SH3KBP1 SRC PIK3CA SHC1 RAB5A CBLB NRAS DNM1 EPS15 HRAS SYNJ1 PIK3CB USP8 TSG101 PTK2 KRAS UBE2D2 UBE2D3 ZFYVE28 SH3GL2 CDC42 EPN1 CHMP3 AMPH GRB2 STAMBP SOS1 HGS RAF1 UBE2D1 EGFR PIK3R1 EGF E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network SMARCA2 RB1 RBL2 CDKN1B MCL1 CDC6 YY1 E2F3 RBBP8 E2F2 CCNA2 CDKN1A PLAU SERPINE1 UXT MYBL2 SULT2A1 XRCC1 CES4A TFDP2 MCM3 MYC CES3 CES2 CES1 CBX5 CES1P1 EP300 TYMS CES5A ORC1 E2F6 E2F7 RANBP1 RRM1 RRM2 CDKN2C TFE3 CCNE2 DHFR POLA1 RYBP KAT2B PRMT5 KAT2A RBL1 TFDP1 SIRT1 TP73 WASF1 HDAC1 HBP1 RBBP4 TRIM28 E2F1 E2F4 CDK1 E2F5 CASP7 BRCA1 CCND3 CREBBP TOPBP1 APAF1 SP1 CEBPA TRRAP CDK2 CCNE1 HIC1 ATM TK1 CDC25A CDKN2A CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway NOD2 TNFRSF1A RAN RIPK2 IKBKG UBE2D3 TRAF6 BTRC BIRC2 NFKB1 CYLD TNFAIP3 NFKBIA ERC1 CHUK BCL10 MALT1 ATM XPO1 TNF IKBKB PRKCA RELA EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling EPHA5 FYN EFNA5 TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells CSK B2M TRPV6 HLA-A PLCG1 LAT CD8B PDPK1 CD8A PRKCQ RASGRP2 RASGRP1 CD86 CD80 PRF1 MAP3K8 NRAS CD3G CD3D LCP2 PRKCB IKBKB PRKCE CD28 CD247 IKBKG KRAS TRAF6 GRAP2 AKT1 CHUK MAP3K14 ZAP70 CBL FYN SHC1 PTPN6 CARD11 BCL10 RAP1A MALT1 HRAS PRKCA LCK PTPRC GRB2 SOS1 PAG1 RASSF5 STIM1 ORAI1 CD3E VAV1 REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase YWHAE CDKN1B CCND1 IFNAR2 NFKB1 JUN FOS IL2 IRF1 IFNG TERF2 BLM MAPK1 SIN3B ABL1 SIN3A MAPK3 MYC AKT1 HUS1 NCL RAD1 TGFB1 PINX1 SAP30 RAD9A SMG6 E6 SMG5 PARP2 TINF2 TERF1 DKC1 POT1 TERF2IP PIF1 TNKS WRN WT1 ACD PTGES3 MTOR HDAC2 ZNFX1 HNRNPC HDAC1 RPS6KB1 MAX RBBP4 TERT E2F1 SAP18 HSP90AA1 RBBP7 MXD1 MRE11 UBE3A NR2F2 SMAD3 NBN ESR1 XRCC6 XRCC5 SP1 SP3 EGFR RAD50 ATM EGF REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein RB1 CDKN1B CDK6 CCND1 ELF1 MET CSF2 SMARCA4 E2F3 BGLAP JUN MAPK9 E2F2 MDM2 CCNA2 ATF2 CDKN1A TGFB2 SPI1 MAPK11 ABL1 EP300 SMARCB1 MEF2C PPP2CA RUNX2 TFDP1 SIRT1 MYOD1 TBP MAPK14 MITF PPARG CEBPB SUV39H1 HDAC3 HDAC1 AATF CTBP1 BRD2 PAX3 RBP2 ATF7 DNMT1 CKM RBBP4 PPP2R3B GSC TAF1 E2F1 E2F4 SFTPD CCND3 CREBBP RAF1 CEBPA CDK4 CDK2 CEBPD CCND2 CCNE1 UBTF SKP2 CBX4 CDKN2A REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling SMAD2 SMAD4 CALM3 SMAD3 MAPK1 TGFBRAP1 CTDSP1 CTDSP2 MAPK3 MAP3K1 KPNA2 NUP214 KPNB1 PIAS4 CTDSPL UBE2I NUP153 PPM1A HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network VEGFA MCL1 EDN1 EPO LEP NOS2 CITED2 SLC2A1 PGK1 LDHA HIF1A EGLN1 EGLN3 COPS5 JUN HMOX1 TF BHLHE40 FOS ABCG2 ID2 ARNT CXCR4 ITGB2 SERPINE1 ETS1 HNF4A NPM1 AKT1 EP300 NCOA1 FURIN NCOA2 TFF3 CREB1 ENG GATA2 NDRG1 HDAC7 TERT IGFBP1 BHLHE41 ADM RORA HK2 HK1 CA9 PGM1 PKM SMAD4 PLIN2 CREBBP GCK ALDOA ABCB1 SMAD3 PFKFB3 FECH NT5E BNIP3 CP PFKL CXCL12 SP1 TFRC ENO1 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway VLDLR GSK3B CBL ARHGEF2 FYN ITGA3 GRIN2B MAP1B PIK3CA LRP8 RAP1A RELN MAPT NCK2 MAP3K11 DAB1 ITGB1 CDK5R1 PAFAH1B1 MAP2K7 MAPK8 GRIN2A CRKL MAPK8IP1 RAPGEF1 LRPAP1 AKT1 CDK5 PIK3R1 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway TNFRSF10C TNFRSF10B TNFRSF10A TNFRSF10D PIK3CA SMPD1 PIK3CB IKBKB CASP8 CASP10 RIPK1 IKBKG FADD MAPK8 CFLAR MAPK1 MAPK3 TNFSF10 DAP3 TRADD MAP3K1 CHUK MAP2K4 PIK3R1 TRAF2 RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling GNG2 CRH MAPK8 GNB1 MAPK9 MAPK11 MAPK14 GNAL SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP INS VEGFA PTPN1 INSR RAB4A STAT6 STAT5A STAT5B STAT1 MET STAT3 SRC PIK3CA SHC1 KPNB1 PIK3CB GAB1 ITGB1 PIAS1 KDR CREBBP PDGFRB GRB2 SOS1 ITGA1 JAK3 PTPN2 PDGFB CSF1R JAK1 LMAN1 EGFR KPNA2 HGF CSF1 EIF2A PIK3R1 ATR EGF EIF2AK2 BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling GREM1 BMP2 GSK3B BMPR1A SMAD9 SMAD5 TAB2 TAB1 PPP1CA SMURF1 CTDSPL PPM1A BMP7 MAP3K7 SMAD4 ZFYVE16 PPP1R15A MAPK1 SMAD7 SKI CTDSP1 SMURF2 CTDSP2 BAMBI XIAP CHRD CHRDL1 NUP214 HJV BMP4 SOSTDC1 CER1 AHSG FST NOG BMPR2 SMAD6 RGMB BMP6 SMAD1 RGMA PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events GNG2 ROCK2 F2RL3 GNB1 ROCK1 GNA13 MYL2 GNA14 GNA15 GNA11 F2RL2 GNAQ RHOA F2 PLCB2 HEDGEHOG%NETPATH%HEDGEHOG Hedgehog DYRK1A IHH ARRB2 KIF7 MED6 KIF27 MED23 MED12 CDK8 CCNB1 ADRBK1 SUFU BOC SAP18 CTNNB1 GAS1 MED1 HEL2 DHH PTCH1 HHIP PTCH2 TCR%NETPATH%TCR TCR MAP2K1 SCAP2 MAP2K2 DYRK1A PRP4K ANXA11 DYRK1B LAX1 TUBA4A CD2AP DOK1 ACLY HGS NCL PARD3 ELMO1 ADAM9 PRKD2 PKP4 PRKD1 RAF1 STAM2 C10orf28 EPHA3 CARD11 KHDRBS1 TSG101 SHC1 TXK SH2D2A PXN STK39 PIK3R2 PIK3R1 PTTG1IP BCL10 STK4 LY9 LDHB SDCBP RAP1A INPP5D CASKIN2 PLCG2 LPXN BMF PLCG1 ICOS PAG1 LYN VASP EGR1 CREBBP FYB1 HEL-S-133P NFATC2 LNPEP NFATC1 CGN NFKB1 CDC2 NFKBIA FER PTPRC EPRS1 UNC119 GRB2 GRAP DKFZp434N041 CALM1 ADA LAT NFKBIB GSK3B ITK MTMR10 DDX3X HSP90AB1 DDX49 HEL-S-30 CLTC GDI2 PTPN22 CD3G PTPRH SHB CD3E CD3D CABIN1 PIK3C2B IKBKB PSTPIP1 TUBA1A YWHAQ CTLA4 ZNF404 JAK3 NCK1 VAV3 DUSP3 CHUK ANXA2 SYK RIPK2 FCRL3 NFAM1 TUBB PGAM1 MSL2 GAB2 YWHAZ VAV1 VAV2 ACTA1 ZAP70 CREB1 BDH1 LCK RAPGEF1 PECAM1 C9orf78 LCP2 EVL ARHGEF2 DOCK2 SOS1 ARHGEF7 CRK SOS2 CEBPB SRC HEL-S-52 WAS NEDD9 ATP1A1 CBL RELA HDAC7 DNAJB1 MUC1 PAK1 MAPK8 MAPK7 PTK2B MAPK1 FLNB CCT8 SH2B3 MPZL1 MAPK3 GIT2 TRAT1 STAT1 ERBIN PTPN11 MAPK14 DEF6 CD2 MAPK11 EIF3M TEC RPS6KB1 CD5 CD7 CTNNB1 PTPN6 PIK3AP1 ACTR10 RAN ITSN2 ATF2 CYFIP1 CD84 CD82 TFRC WIPF1 HEL-S-81p DGKA CD80 SLA ENO2 ARHGAP35 CRKL GOLGA5 UBASH3B SIT1 GRAP2 ARHGDIB TRIM25 MAP3K8 HOMER3 KIRREL1 BCR%NETPATH%BCR BCR RPS6 FOS VAV1 LAT2 DOK1 ZAP70 CREB1 LCK BANK1 MAPKAPK2 RAPGEF1 BTK HCLS1 PRKCQ PRKD1 SOS1 CRK SOS2 CARD11 SHC1 ITPR2 NEDD9 PIK3R2 BCL10 RELA RASGRP3 CD79B CD79A CCL4 BTLA EIF4EBP1 CCL3 STAP1 MAPK1 PIP5K1A FYN PIP5K1C PLCG1 SH2B2 LYN PTPN18 JUN CD72 PLEKHA1 PLEKHA2 STAT1 STAT3 NFATC3 NFATC2 MAPK14 CDK7 HNRNPK TEC BCL6 RPS6KB1 CDK2 CTNNB1 FOSB CYCS BAX GRB2 PTPN6 FCGR2B CD22 RB1 ATF2 GSK3B ITK GSK3A IFITM1 SLA2 STM7 CRKL IKBKB CASP9 TCL1A RPS6KA1 BLNK PIP4K2A PIP4K2B FOXO3A JUNB GTF2I NCK1 MAP4K1 CHUK PDPK1 PRKCB IL1%NETPATH%IL1 IL1 MAP2K3 JUN FBXW5 CHUK IL1R1 IL1R2 IRAK3 IRAK4 HEL-S-44 MAPK14 NFKB1 NFKBIA MAP3K7IP1 DOK1 IL1A IL1B TRAF6 PELI1 REL TAB3 UBE2V1 MAP3K14 MYD88 RB1 ATF2 HEL-S-71 IL1RN PIK3R2 PIK3R1 IKBKAP RELA IKBKB PPP6C MAPK9 MAPK8 IRAK1 IRAK2 MAPK1 MAPK3 MAP2K6 MAP3K2 IL2%NETPATH%IL2 IL2 CDK2 IL2RB BCL2 GRB2 PTPN6 EIF3B ATF2 IRS1 PIK3CD YBX1 NR3C1 SHB ETS2 CRKL FOXO3A JAK3 JAK1 MAP2K1 MAP2K2 IL15 RPS6 GAB2 VAV1 CREB1 PIK3CA LCK CCNE1 PLCB1 RAF1 SGK1 SOS1 STAM2 CRK SHC1 PIK3R3 PIK3R2 PIK3R1 IL2RG CBL PRKCZ RELA SOCS3 MAPK8 TERT EIF4EBP1 STAT4 PTK2B MAPK1 FYN EIF4E MAPK3 LYN STAT5B JUN PTPN11 NMI MAPK14 MTOR IL2 NFKB1 IL2RA IL3%NETPATH%IL3 IL3 MAP2K1 PRKCB BAD KCNIP3 PRKCA GAB2 YWHAZ NFKB1 DOK1 IL3 CREB1 PTPRC FES RARA PTPN6 CRK BCL2L1 ATF1 GSK3B GSK3A SHC1 PIK3CD CSF2RB PIK3R2 PIK3R1 GATA2 FOXO1 CRKL PPP2CA SOCS2 SOCS3 BCL2L11 RXRA INPP5D MAPK1 HEL-S-1 HRAS LYN IL4%NETPATH%IL4 IL4 INPP5D PLCG2 EP300 MAPK1 IL13RA1 JAK1 MAPK3 CREBBP CHUK SYK BAD IL13 STAT3 PTPN11 TYK2 MAPK14 SND1 NFKB1 IL4 NFKBIA MAPK11 H3-4 PIK3CA RPS6KB1 PTPN6 CEBPA ATF2 CEBPB CD40 SPI1 SHC1 PIK3CD CXCR4 IL2RG CBL IKBKB H3C15 MAPK8 SOCS1 IL5%NETPATH%IL5 IL5 JUN MAP2K2 SYK STAT1 STAT3 PTPN11 MAPK14 YWHAZ NFKB1 NFKBIA IL5 IL2RB RAPGEF1 CTNNB1 HCLS1 BAX UNC119 GRB2 RAF1 SOS1 ATF2 GSK3B GSK3A SHC1 IL5RA CBL CRKL SDCBP SOCS1 ALOX5 RPS6KA1 PTK2B FOXO3A HRAS SOX4 JAK1 LYN STAT5B IL6%NETPATH%IL6 IL6 RB1 GSK3B CD40 EP300 FOXO3A RAC1 IL6R MAP3K7 JAK1 EIF2A NCOA1 HEL-S-102 MAP2K4 MAP2K1 MAP2K2 FOS TYK2 GAB2 VAV1 BTK IL6ST SGK1 HDAC1 SHC1 PIK3R2 FOXO4 PIK3R1 NLK CBL FOXO1 SOCS3 MAPK8 ERBB3 ERBB2 EIF4EBP1 PTK2B MAPK1 FYN PLCG1 EIF4E MAPK3 MAP2K6 LYN STAT5B CREBBP JUN BAD STAT1 STAT3 PTPN11 MAPK14 BMX c-fgr NFKB1 CDK9 IL6 RPS6KB1 GRB2 IL-7%NETPATH%IL-7 IL-7 SHC1 STAT1 STAT3 PIK3R1 IL2RG FOXO1 IL7 MAPK1 FYN FOXO3A IL7R JAK3 MAPK3 GSK3B STAT5B GSK3A MAP2K1 MAP2K2 IRS1 BAD ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin ARHA GRB2 TP73 HEL2 RTKN IRS1 ITGB4 HEL113 PIK3CD LAMC2 LAMC1 MYLK3 YWHAQ CASP3 HEL-S-1 RAC1 EPHB2 DST RPSA PRKCA FOS YWHAZ PIK3CA ITGA6 MET PLEC COL17A1 LAMA5 CD151 SHC1 SRC LAMA3 PIK3R3 PIK3R2 MST1R PIK3R1 NTN1 EGFR PAK1 ERBB2 EIF4EBP1 CLCA1 MAPK1 FYN SFN EIF4E MAPK3 SMAD2 JUN YES1 LAMB3 LAMB2 BAD ERBIN LAMB1 PTPN11 MAPK14 MTOR EIF6 IL9%NETPATH%IL9 IL9 STAT5B KAT5 MAPK1 TYK2 IL9R MAPK3 RANKL%NETPATH%RANKL RANKL MAPK8 TRAF3 TRAF6 TRAF5 REL TNFSF11 ATP6V1E1 MAP3K7 SQSTM1 SPI1 CHUK TNFRSF11B TREM2 TRAF2 TRAF1 MAPK14 NFKB1 NFKB2 MAP3K7IP1 LEPTIN%NETPATH%LEPTIN Leptin MAPK8 CFL2 RPS6KA2 ERBB2 EIF4EBP1 PLCG2 MAPK1 FYN PLCG1 EIF4E SOCS7 JAK3 SH2B1 JAK1 NCOA1 CHUK STAT1 PRKCE LIMK1 RPS6 RUNX2 NFKBIA CDK5 RPS6KB1 LEP PDE3A GRB2 CRP KHDRBS1 GSK3B GSK3A PRKAA1 PRKAA2 ITGB5 IRS1 SHC1 SRC IRS4 SLC2A4 ACACB EGFR IGF1R IKBKB TSH%NETPATH%TSH TSH GNA13 GNAO1 IKBKB CREB1 GNA11 LEP CANX GNAS RAF1 MAPK3 MAP2K6 MAP2K3 GNAI3 SCRIB ATP1A1 HEL-S-99n GNAI1 TSHR HEL-S-89n IGF1R TSLP%NETPATH%TSLP TSLP MAPK1 EIF4E MAPK3 STAT5B MAP2K1 STAT1 STAT3 MAPK14 NFKB1 RELA NFKB2 RELB NFKBIA MAPK9 MAPK8 STAT4 FSH%NETPATH%FSH FSH MAP2K2 GRK4 FSHB FSHR CGA APPL1 ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR AndrogenReceptor HEL-S-102 CREB1 HDAC1 PIK3R1 NOTCH%NETPATH%NOTCH Notch PSEN2 DTX1 FURIN PIK3R1 RBPJ RELA DLL3 LFNG DLL4 YY1 APH1B SIN3A MAGEA1 EP300 MAPK1 CIRSR HES1 CCN3 SKP2 MAPK3 SKP1 SPEN JAG2 PSENEN SMAD1 HES6 FBXW7 STAT3 NFKB1 SAP30 RBX1 NCOR2 KAT2B SNW1 NCOR1 MFNG MAML3 TCF3 NOTCH2 GSK3B APP HDAC2 MAML2 SRC MAML1 FHL1 LEF1 EGFR1%NETPATH%EGFR1 EGFR1 TRIP6 SDC1 CC2D1A ARF4 PYGB CLTC RPLP0 CLTA AP2A1 PTPRK WASL ARHGAP5 SHB LIMD1 PTPRF PS1TP5BP1 OTUD6B ENSA RAC1 PLEKHN1 HRAS APPL2 APPL1 JAK1 SERPINB3 CDV3 ANXA1 ANXA4 PGAM1 MINK1 FOS EPS15L1 TYK2 VAV1 VAV2 PLSCR1 GPRC5A KIT ARHGEF4 ARHGEF7 ARHGEF5 CSTB HEL-S-87p PHLPP1 AHNAK HTT NEDD9 RPS27L PRKX SNX33 EGFR RELA PAK1 PDZD11 AP2S1 FLNB RICTOR CD59 RPS2 LDLR MPZL1 GIT2 CAVIN1 CAVIN2 STAT2 HUWE1 PLEKHA5 ERBIN PLEKHA6 HIPK2 ITCH KRT18 ARHA AXL NEDD4 PKN2 EPPK1 ESYT1 FRK SH3GL3 CTNND1 INPPL1 ARHGAP35 ARHGAP42 STK11 C11orf52 LAPTM4A CYSRT1 CDH2 GRB14 HNRPR GRB10 SIRPA KRT6A MAP2K3 MAGI1 RALBP1 KIRREL1 MAP2K1 MAP2K2 DYRK1A PRP4K DYRK1B TOM1L1 EEF1A1 TOM1L2 DOK1 ADAM17 EEF1A2 HAT1 PKP2 ELMO2 ADAM9 PKP4 STAMBP PKP3 RAF1 PHLDB2 COL17A1 KHDRBS1 HEL-S-132P DAPP1 FOXO4 LPP FOXO1 PLD2 EFNB2 SDCBP SOCS3 ATXN2 SOCS1 UBB HNRNPDL CALD1 CASKIN2 EIF4EBP1 ABL2 RIPK1 SMAD2 HEL-S-94n CAV2 TNK2 CRIM1 HEL-S-133P NFKB1 PTPRE ARHGAP32 CDK5 SP1 CDK2 ALB BCL2 RAB5A MAP3K14 EIF4G1 ITGB1 HEL-S-112 GSK3B DYRK4 GSK3A DYRK3 DOCK4 DDX3X USP31 CALCOCO2 ITGB4 HEL-S-30 HEL-S-115 HEL-S-36 PTEN PIK3CD HEL-S-34 PIK3C2B RBM3 CASP9 FLOT1 NCK2 HEL-S-1 CCDC50 NCK1 ACTR3 TGIF1 ACTR2 PDCD6IP PDPK1 LSR ARAP1 YWHAZ EPN1 EPN2 EPN3 ACTA2 SFPQ CREB1 ELF3 PIK3CA LCK MYH9 DSG2 CRK DOCK1 MET SLC25A6 PLEC CEBPA CEBPB PRKAA1 PRKAA2 RALB WBP2 HDAC1 RGS16 MVP ITLN2 ASAP1 ATP1A1 SRI CDC42 MAPK9 MAPK8 MAPK7 MARVELD2 ERBB3 ERBB2 SLITRK6 REPS2 PTK2B MAPK1 CSK FYN RBBP7 MTA2 PDLIM4 SH2B1 SNCA PTPN18 PTPN1 PPP1R14B HEL-S-43 EGF BAD SPRY4 BAIAP2 MAPK14 MTOR H3-4 RPS6KB1 SPRY2 SPRY1 KRAS PTPN6 TIEG2 DNCL1 SPG20 NECTIN1 ZPR1 ATF1 ITSN2 USP6NL APP ERRFI1 RPL30 AHCYL1 TFRC ZDHHC5 ARAF HEL113 CBLC HEL114 ENO1 ANTXR1 CRKL RPS6KA3 GJA1 BAIAP2L1 RPS6KA5 TFG SNRPD2 UBASH3B TRIM29 MYC RPS6KA2 RPS6KA1 EPHB2 ANKS1A TNS4 SLC12A7 EPHB1 RPS10 TNS3 EPHB4 TNS2 EPHB3 TNS1 EPHA4 PRKCI ACTN1 KRT7 FRS2 SCRIB PRKCA KRT5 ACTN4 FRS3 SCAMP3 KIAA1217 GAREM1 ZFYVE16 PRKAR1A PARD3 RBCK1 PRKD1 EPHA1 PFN1 TLN1 RIN1 EPHA2 GRB7 SDC4 CTBP1 SDC3 PIK3R3 PIK3R2 PIK3R1 PTTG1IP IQGAP1 MYL12B HEL-S-15 SLC5A5 MYO6 PLCG2 COX2 PLCG1 S100A14 STX4A SNX5 S100A10 LYN VASP STAT5B JUN JUND JUP HEL107 INSR BRAF CDC2 SMU1 CYLD ID%NETPATH%ID ID RBL1 PSMD4 CDK2 ID3 MAPK1 HES1 TCF3 RAF1 ATF3 MYF5 MAPK3 RB1 TCF7L2 MAP2K1 MAP2K2 SMURF2 FHL2 PAX5 ELK3 RBL2 KITRECEPTOR%NETPATH%KITRECEPTOR KitReceptor PTPRU ATF2 GSK3B WIPF1 CLTC CRKL GYS1 SPRED1 RPS6KA1 EP300 HRAS JAK3 HEL70 PRKCB RPS6 MATK PRKCA PIK3CA KIT RAF1 SOS1 EZR CRK GRB7 SRC WAS CSF2RB PIK3R1 RELA MAPK8 SOCS1 INPP5D EIF4EBP1 MAPK1 FYN SOCS6 SOCS4 SOCS5 STAT5B JUN YES1 STAT1 RDX PTPN11 TNFRSF10A MAPK14 EPOR c-fgr MTOR MAPK12 KITLG TEC RPS6KB1 FES CDK2 GRAP IL7R MAD2L1 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_beta_Receptor CTNNA2 E2F4 SAMD3 MAPK3 NFYA NR1i1 NFYB NFYC PML FKBP1A SKI MAP3K7IP1 FOSB RB1 ATF2 SPARC ZFYVE9 UBE2D2 UBE2D3 UBE2D1 PPP2R2A NR2A1 HOXA9 STK11 CDC23 FNTA CCND1 MYC SNIP1 FOXO3A SOX9 BTRC JUNB VPS39 SKP1 MAP2K3 NUP214 MEF2C ANAPC7 RUNX3 RUNX2 RUNX1 RBX1 EID2 ZFYVE16 PRKAR1B EWSR1 CCNE1 SIK1 ANAPC5 ATF3 ANAPC1 ANAPC2 SDC2 PXN PIK3R2 FOXO4 PIK3R1 ANAPC10 FOXO1 SNX4 CCNB2 SNX1 SNX2 SPTBN1 MAP2K6 SNX6 WWTR1 JUN SMAD4 JUND TGFB1 UBE2I STK11IP SMURF1 IRF2BP1 NUP153 SMAD6 CDK6 COPS5 SNW1 CDK4 SP1 DYNLRB2 DCP1A TP73 GSK3B CDKN1A CITED1 CTCF ARRB2 BRCA1 XPO4 SUMO1 MAP4K1 NCOA1 PDPK1 HEL-S-72p FOS PJA1 TGFBR2 RBL2 TGFBR3 KAT2B ZEB2 TFDP1 EIF3S2 PIK3CA TFDP2 CRK CD44 ENG YAP1 PPP1R15A HDAC1 FZR1 PARD6A STAMBPL1 CTNNA1 MAPK1 WNT%NETPATH%WNT Wnt DIXDC1 ARRB2 STM7 SOX1 CCND1 HEL-S-1 RAC1 MAP3K7 PRKCB AXIN1 KREMEN1 PRKCA DKK1 PAX2 SFRP1 DAAM1 ARHGEF4 ROR1 PI4K2A CTBP1 LEF1 LRP5 NLK MESD PPP2CA MAPK8 FRZB GPC3 DVL3 WNT1 WNT3 FZD1 SMAD1 TCF7L2 JUN YES1 JUP FZD5 SETDB1 CSNK1A1 FZD4 FZD7 FZD9 NFATC2 BCL9 CDK6 ARHA PIN1 TCF4 TNFALPHA%NETPATH%TNFALPHA TNFalpha DOK1 TXLNA CDC34 FANCD2 CDC37 MAPKAPK2 TXNIP TRIB3 NUPR1 FKBP5 NSMAF COPB2 PSMD12 DIABLO PSMD13 TXN TNFRSF11A FOXO1 GLG1 BAG4 BRINP1 G3BP2 FADD MAP2K5 MAP2K6 CREBBP JUN UBE2I CRADD SEC16A MCC NFKB1 SMARCA4 CDK9 NFKBIA REL ALPL TAB3 GRB2 NFKBIE MAP3K11 BCL2L1 RNF11 DDX3X HSP90AB1 MCM7 FAF1 IKBKAP PPP6C YWHAQ BCL7A SUMO1 PPP1R13L NKIRAS1 CASP10 NKIRAS2 CASP3 NFKBIZ CASP2 HEL-S-1 IKBKG IKBKE YWHAG HEL-S-102 RIPK3 PEG3 ACTL6A COMMD1 TNFRSF1B YWHAZ CREB1 RASA3 TRAF4 MUXA POLR1A TRAF6 TRAF5 POLR1C POLR1D MCM5 PFDN2 SOS1 SOS2 BIRC2 BIRC3 HDAC2 HDAC1 SRC USP11 AKAP8 MTIF2 NR2C2 TANK HDAC6 EGFR RELB MAPK9 PAK1 MAPK8 RXRA ERBB3 TIFA FLNA MAPK1 ROMO1 POLR2H RFFL POLR2L MAPK3 MAP3K2 SMARCE1 RNF25 STAT1 PTPN11 MAPK14 LRPPRC PML KTN1 MAP3K7IP1 ITCH GLB1 TNIP2 PRC1 PSMC1 BAX PDCD2 TBKBP1 PKN1 TRIM32 RB1 RPL4 RPL30 HEL2 IRS1 UBE2D2 UBE2D3 ZFAND5 RPL8 TNF DCAF7 RPL6 FBL PSMD6 TBK1 PSMD7 RPS6KA5 PSMD2 PSMD3 PAPOLA KPNA6 DPF2 EP300 PSMD1 TNFRSF8 MAP3K8 KPNA2 RPS11 BTRC JUNB KPNA3 RPS13 GTF2I MAP3K5 SKP1 SMARCC1 SMARCC2 CSNK2A1 FBXW11 FBXW7 USP2 CYBA PRKCA 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis PLCB3 DAGLA LIPH LPL PLCB1 PLCB2 PLA1A 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway GNB4 GNB3 GNB5 KCNK3 KCNK9 GNAI3 PRKX ADCY2 ADCY7 GNAI1 GNAI2 GNG10 GNG3 GNGT2 GNG2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNG8 PRKACA PRKACB HTR1E HTR1F HTR1D HTR1A HTR1B GNG12 GNG11 GNAO1 GNB2 GNB1 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway PLCL1 PRKCD PRKCA GNG12 GNG11 PLCB3 PLCB4 GNAQ GNB2 GNB1 GNB4 GNB3 PRKCQ GNB5 PLCB1 PLCB2 PLCD4 PLCD1 HTR2B HTR2C HTR2A PRKCZ GNA14 GNG10 GNG3 GNGT2 GNG2 GNG5 PLCZ1 GNG4 GNG7 GNA11 PLCG2 PLCE1 GNG8 PLCG1 PRKCG PRKCI PRKCH PRKCB PRKCE 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway GNB4 GNB3 GNG8 GNB5 ADCY2 HTR4 GNG12 ADCY7 GNG10 GNG3 GNGT2 GNAL GNG2 GNG5 GNG4 GNG7 GNB2 GNB1 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis TPH2 TPH1 DDC 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation ALDH16A1 ALDH8A1 ALDH7A1 ALDH9A1 ALDH1L1 MAOB MAOA ALDH1L2 ALDH4A1 ALDH3A2 ALDH3A1 ALDH1A3 ALDH3B2 IL4I1 ALDH2 ALDH1B1 ALDH1A2 ALDH1A1 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization ACSS3 ACSS2 ACSS1 ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway PNP HPRT1 XDH ADA PRTFDC1 APRT ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis SLC6A2 SLC18A1 SLC6A3 SLC18A2 SLC6A19 SLC6A18 SLC6A17 SLC6A16 SLC6A15 SLC6A20 ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis BCAT1 BCAT2 ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation ALLC ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway PRKCG PRKCE PRKCD ITPR1 PRKCA ADRA2C ADRA1B ADRA2B ADRA1A ADRA2A PLCB3 PLCB4 GNA11 PLCE1 PLCB1 PLCB2 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway APP KAT5 PRKCG PSENEN PRKCI PRKCH PRKCB PRKCE PRKCD PRKCA BACE1 CACNB1 CACNB2 BACE2 ADAM17 PRKCQ PKN3 CHRNA7 PSEN2 CACNA1D PSEN1 CACNA1C CACNA1F KLC1 PRKCZ MAPK9 KLC4 MAPK8 KLC3 NCSTN MAPK7 APH1B KLC2 MAPK1 CACNA1S MAPK6 MAPK4 MAPK3 MAPK14 MAPK15 MAPK12 MAPK13 MAPK10 MAPK11 APBA1 PKN2 CHRFAM7A PKN1 APBA3 APBA2 ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway WNT8A LRP4 WNT8B LRP3 PSEN1 LRP2 FSTL1 LRP6 WNT6 NCSTN WNT11 APH1B ERBB4 DVL1 DVL2 DVL3 APBB2 WNT1 APBB3 WNT2 WNT3 WNT4 FZD1 WNT10B TCF7L2 WNT10A TCF7L1 FZD3 FZD2 JUP FZD5 WNT3A FZD4 FZD7 WNT7B FZD6 FZD9 WNT7A FZD8 LRP1B AFDN ACTC1 CTNNB1 NECTIN1 APP GSK3B WNT2B FZD10 RBPJ ACTB ACTG2 ACTG1 CDH3 KAT5 CDH1 TRIM2 TRIM3 KAT7 TRPC7 PSENEN ACTR2 TRPC5 TRPC6 WNT5B TRPC4 TRPC1 WNT5A WNT9B WNT9A WNT16 ERN1 BACE1 ACTA2 ACTA1 BACE2 ACTBL2 CD44 NOTCH2 RBPJL NOTCH3 NOTCH1 LRP1 NOTCH4 LEF1 LRP5 PSEN2 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation ABAT ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation FAAH ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis CYP19A1 LIPA SOAT1 SOAT2 HSD17B1 HSD17B2 HSD17B3 HSD17B6 HSD17B7 ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis PLA2G4A FOS RHOC RHOA RHOB PIK3CA RASA1 BIRC5 PIK3C3 CRYAA SOS1 CRYAB CRK SOS2 RBPJL SRC DLL1 DLL3 DLL4 NRAS MAPK8 PAK1 MAPK1 PAK3 PAK2 MAPK3 TCF7L2 MAP3K1 ANGPT1 NOS3 STAT1 WNT7B STAT3 WNT7A MAPK14 DLK1 VEGFA APC CTNNB1 TEK ARAF FGF1 RBPJ ETS1 CRKL GRB14 AKT2 AKT3 KDR AKT1 EPHB2 EPHB1 EPHB3 PRKCG PDGFRB PDGFRA MAP2K4 PRKCI MAP2K1 PRKCH MAP2K2 WNT5B PRKCB PRKCE F2R WNT5A PRKCD PRKCA FRS2 FRS3 DOK1 DOK2 DOK3 MAPKAPK3 PRKD3 MAPKAPK2 PRKCQ PRKD2 PRKD1 RAF1 EPHA3 NOTCH2 GRB7 SHC2 NOTCH1 SHC1 NOTCH4 SH2D2A TCF7 PXN PDGFB PDGFA PIK3R3 PIK3R2 PIK3R1 PLD1 PRKCZ HIF1A PLD2 EFNB2 EFNB1 PDGFD DVL1 PDGFC DVL2 PLCG2 LPXN DVL3 PLCG1 WNT1 WNT2 FZD1 JAG2 WNT10B JUN WNT10A FZD3 JAG1 FZD2 FZD5 BRAF PTK2 GRAP FGFR1 PRR5 GSK3B ARHGAP8 WNT2B TGFB1I1 ARHGAP1 PIK3CD HSPB1 PIK3CB PIK3C2A PIK3CG PIK3C2B CASP9 NCK2 HRAS NCK1 JAK1 APC2 PLA2G4D SPHK2 PLA2G4B SPHK1 PLA2G4C AXIN1 ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin PLCB1 PLCB2 ITPR1 ITPR2 ARRB1 ITPR3 ARRB2 ELK1 GRK3 GNG10 GNG3 GNGT2 GRK2 GNG4 GNG7 MAPK1 GNG8 MAPK3 EGR1 MAP2K1 MAP2K2 PRKCA GNG11 AGT PLCB3 GNAQ GNB2 GNB1 AGTR1 GNB4 GNB3 GNB5 RAF1 APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway TNFRSF1A PIK3CA MADD LTA ATF7 PRKCQ LTB TP53 ATF6 ATF3 BIRC2 JDP2 ATF4 BIRC3 ATF6B DIABLO CREM XIAP RELA RELB MAPK9 MAPK8 BCL2L11 MAPK1 RIPK1 FADD BAK1 MAP2K7 MAP4K3 MAP4K4 MAPK3 JUN MAP3K1 CRADD BIK TNFRSF10C TNFRSF10B GZMB EIF2AK2 TNFRSF10A EIF2S1 IGF2R NFKB1 GZMH NFKB2 TNFRSF10D NFKBIA MAPK10 PRKRA BCL2 REL FAS CYCS BAX MAP3K14 BCL2L1 ATF1 ATF2 TRADD PIK3CD FASLG PIK3CB TNF PIK3CG IKBKB CASP9 CASP7 CASP8 AIFM1 CASP10 AKT2 CASP3 AKT3 TNFSF10 AKT1 MAP3K5 PRKCG MAP2K3 MAP2K4 MAP4K2 DAXX PRKCH ENDOG APAF1 CHUK PRKCB PRKCE PRKCD PRKCA TRAF2 FOS TNFRSF1B ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis CPS1 CAD ASL NAGS ASS1 OTC ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation RPE ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis ASNS ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis ATP5F1B ATP5F1C AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin NTN4 PIK3CD PIK3R3 PIK3R2 PIK3R1 PIK3CB PIK3C2A NTN1 PIK3CG NTN3 PIK3C2B PIK3R5 CDC42 ABLIM1 RAC2 PLCG2 PLCG1 RAC1 VASP NTNG1 NTNG2 DCC UNC5B NFATC3 NFATC2 UNC5C UNC5D NFATC4 PIK3CA RHOU AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins PLXNA1 PLXNB1 FYN ARHGEF1 RAC1 FRK NRP1 SEMA4D DPYS SEMA3A CRMP1 RHOA PAK1 DPYSL4 CDK5 FES DPYSL5 DPYSL2 RAC2 AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo SLIT3 SLIT2 RAC1 SRGAP1 NTNG1 NTNG2 DCC NTN4 CXCR4 RHOC NTN1 NTN3 ROBO1 CDC42 CXCL12 SLIT1 ABL1 RAC2 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation ARAF PIK3CD PIK3CB PIK3CG IKBKB PPP3CA PPP3CB RAC2 BLNK RAC1 HRAS VAV3 MAP2K1 MAP2K2 CHUK SYK PRKCB NFKBIL1 PRKCD FOS VAV1 VAV2 PIK3CA BTK RAF1 SOS1 SOS2 ITPR1 ITPR2 ITPR3 CD79B CD79A MAPK9 NRAS MAPK8 CD19 PLCG2 MAPK1 MAPK3 LYN MAP3K2 MAP3K3 JUN MAPK14 MAPK12 MAPK13 NFKBIA MAPK10 MAPK11 PTPRC PTPN6 GRB2 CALM1 CD22 BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway GNAL GNG2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 PRKACA PRKACB ADRB1 PRKX ADCY2 GNG12 ADCY7 GNG10 GNG3 GNGT2 BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway GNAL GNG2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 PRKACA PRKACB PRKX ADCY2 ADRB2 GNG12 ADCY7 GNG10 GNG3 GNGT2 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway GNB4 GNB3 GNG8 GNB5 ADCY2 GNG12 ADCY7 GNG10 GNG3 GNGT2 GNAL GNG2 ADRB3 GNG5 GNG4 GNG7 GNB2 GNB1 BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation PROS1 ITGA2B SERPINA10 PROZ PLG PLAT TFPI KNG1 THBD PLAU FGB FGA F10 VWF GP1BB F12 FGG F2R PLAUR GP1BA F2 F3 GP5 F7 GP9 PROCR F8 F9 PROC F13B KLKB1 F2RL3 BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation CYP2B6 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway TCF7L1 PCDH9 PCDHGC5 PCDH7 WNT7B PCDHGC4 PCDH8 PCDHGC3 PCDHB15 WNT7A PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB10 ACTC1 PCDHB16 CTNNB1 PCDH11Y CTNND2 CTNND1 PCDH11X FZD10 CELSR1 CELSR2 CDH9 CDH8 ACTB ACTG2 CELSR3 ACTG1 CDH7 CDH6 CDH5 CDH4 CDH3 CDH2 CDH1 PCDHAC2 PCDHAC1 WNT5B WNT5A PCDHA13 PCDHA12 PCDHA11 PCDHA10 PCDH10 PCDH15 PCDH12 PCDH19 PCDH18 WNT6 PCDHA1 CDH20 CDH22 CDH23 PCDHA5 CDH24 PCDHA4 PCDHA3 PCDHA2 WNT1 PCDHA9 WNT2 PCDHA8 WNT3 PCDHA7 WNT4 PCDHA6 FZD1 WNT10B WNT10A FZD3 FZD2 FZD5 WNT3A FZD4 FZD7 PCDH20 FZD6 FZD9 FZD8 PCDHGA10 PCDHGA11 PCDHGA12 FER PCDHB2 PCDHB1 FAT1 PCDHB6 FAT2 PCDHB5 FAT3 DCHS1 PCDHB4 PCDHB3 PCDHB8 PCDHB7 PCDHGB7 WNT2B PCDHGB6 PCDHGB4 PCDHGB2 PCDHGA8 ACTR2 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA3 PCDHGA2 PCDHGA1 WNT9B WNT9A WNT16 ACTA2 ACTA1 ACTBL2 CDHR1 CDH10 CDH11 CDHR2 CDH12 PCDHGB1 CDH13 CDH15 CDH16 CDH17 CDH18 CDH19 LEF1 WNT8A WNT8B FSTL1 WNT11 PCDH1 PTPN1 TCF7L2 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism SUGCT GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 MAPK10 RPS6KB1 CAMK4 CTNNB1 BAX BCAR1 ATF2 IRS1 ARAF CLU ELK1 ELK4 RPS6KA3 PLAU CDH1 PRKACG RPS6KA1 AKT1 PRKACA PRKACB IER3 MAP2K4 MAP2K1 MEF2C PRKCH MAP2K2 MEF2B PRKCB PRKCE RPS6 PRKCD PRKCA PRKCQ PRKD2 PRKD1 RAF1 CETP SHC1 ARHGEF28 PXN CREM ITPR1 PIK3R1 FOXO3 FOXO1 EIF4EBP1 PLCG1 MAP2K5 MAP2K6 LYN EGR1 JUN YES1 NFATC2 BRAF PTK2 NFKBIA SP1 RHEB GNB1 SP3 SNAI1 BCL2 TCF4 GRB2 CALM1 MAP3K14 MAP3K11 BCL2L1 ITGB1 RYR1 GSK3B RYR2 CXCL8 YWHAB HSPB1 ARRB2 PIK3CB ELAVL1 RYR3 PPP3CA CASP3 CD38 GAST ITGAV NOS1 RAC1 JAK2 SLC18A2 PRKG1 PDPK1 MMP3 PLA2G4A FOS RHOA CREB1 CCKBR TRAF6 AKT1S1 PPARG SOS1 CRK HBEGF GUCY2D ROCK1 SRC SRF ODC1 ADCY1 PTGS2 NR2C2 HDAC7 AKAP1 CDC42 MAPK9 MAPK8 PAK1 GNG2 MAPK7 MAPK1 PTK2B EIF4E MEF2D MAPK3 BAD STAT3 CCK PTPN11 MAPK14 TPCN2 TPCN1 CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle CCND3 CCND2 CCNE1 RPA3 CINP CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis HMGCS1 IDI2 PMVK MVD PDSS1 HMGCR LSS FDFT1 FDPS SQLE MVK GGPS1 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system BMAL1 CLOCK PER2 PER1 PER3 CRY2 CRY1 CSNK1D CSNK1E COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis PANK4 PANK2 PANK3 PANK1 PPCS DCAKD COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism SUGCT CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway GNG5 GNG4 GNG7 GNA11 GNAQ GNB2 GNB1 CRH GNB4 GNB3 GNG8 GNB5 GNG12 CRHR1 CRHR2 POMC GNA14 GNG10 GNG3 GNGT2 GNAL GNG2 CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis CBS CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase MYLK2 ARPC1B ARPC1A STMN4 WASL ACTB ACTG2 MYLK3 ACTG1 MYLK TUBB8 TUBB6 TUBB3 CFL2 STMN1 CFL1 TUBB1 RAC2 RAC1 TUBB RHOC ACTA2 MYH1 ACTA1 TUBB2B MYH2 MYH3 TUBB2A ACTBL2 MYO3B MYO3A MYH8 MYH9 RHOU PFN1 MYH4 MYH6 PFN3 MYH7 PFN2 ROCK1 ROCK2 CDC42 PAK1 MYH13 MYH14 PAK6 MYH11 PAK3 MYH10 PAK2 PAK5 PAK4 MYH7B LIMK1 ARPC4 ARPC5 TUBB4B TUBB4A DIAPH1 DIAPH2 ACTC1 ARPC2 ARPC3 DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis AK1 GMPS AK2 AK3 AK4 AK5 AK8 ATIC GUK1 PPAT RRM1 ADSL RRM2 NME2 NME3 NME4 NME5 NME1 NME6 RRM2B NME7 IMPDH2 ADSS1 ADSS2 GART DSCAML1 DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis RRM2B NME2 NME3 NME4 TYMS DSCAML1 NME1 ADAT2 DTYMK RRM1 DUT RRM2 DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis CTPS1 DSCAML1 NME1 DHODH CPS1 CAD NME2 NME3 CTPS2 NME4 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication TOP1 DNA2 TOP2A RFC5 TOP2B RFC3 PCNA RFC4 RFC1 RFC2 PRIM1 RPA2 POLA1 H3-5 H3-4 POLD1 POLD2 PNAT%PANTHER PATHWAY%P05912 PNAT PRKAR2A PRKACG EPB41L3 FLNA GNG8 DRD1 STX3 DRD2 PRKACA SNAP29 PRKACB DRD4 SLC18A2 DRD5 GNG11 PPP1CA VAMP8 GNB2 GNB1 PPP1R1B GNB4 GNB3 VAMP1 KCNK3 VAMP2 VAMP3 CLIC6 GNAZ SNAP25 KCNK9 EPB41 SNAP23 GNAI3 PRKX ADCY2 ADCY7 GNAI1 SLC6A3 GNAI2 PPP1CC GNG3 PRKAR2B GNG4 EPB41L1 EPB41L2 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway PRKD2 PRKD1 RAF1 SOS1 SOS2 PHLDB2 SHC2 SHC3 SHC1 RASAL2 PRKCZ EGFR PIK3R5 MAPK9 NRAS MAPK8 RRAS ERBB3 ERBB4 ERBB2 PLCG2 STAT4 MAPK1 STAT6 PLCG1 MAP2K7 MAPK3 MAP2K6 STAT5A MAP3K2 STAT5B MAP3K3 STAT1 STAT2 STAT3 SPRY4 DAB2IP BRAF MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 SPRY3 NF1 SPRY2 SPRY1 GRAP ARAF PIK3CD PEBP1 PIK3CB PIK3C2A PIK3CG PIK3C2B AKT2 PEBP4 AKT3 RAC2 AKT1 RAC1 HRAS MAP3K4 MAP3K5 PRKCG MAP2K3 MAP2K4 PRKCI MAP2K1 RASA4B PRKCH MAP2K2 PRKCB PRKCE PRKCD GAB1 RRAS2 PRKCA GAB3 GAB2 MRAS PIK3CA RASA4 PRKD3 RASA1 RASA2 PRKCQ PIK3C3 ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling GNG3 PLCB3 GNGT2 GNG5 CNR1 GNG4 GNG7 GNB2 GNB1 GNB4 GNB3 GNG8 PLCB1 PLCB2 GNAI3 CACNA1B CACNA1A GNG11 GNAI1 GRM1 CACNA1G GNAO1 GRM5 UNTITLED%PANTHER PATHWAY%P00019 untitled GUCY1B1 ARAF EDNRA EDNRB PRKACG AKT2 AKT3 AKT1 PRKG2 PRKACA PRKACB PRKG1 PRKCG GUCY1A2 EDN1 PRKCI GUCY1A1 MAP2K1 EDN2 PRKCH MAP2K2 EDN3 PRKCB PRKCE PRKCD PLA2G4A PRKCA PLCB3 ADCY9 PLCB4 PRKAR1B PRKAR1A PRKCQ RAF1 PLCB1 PLCB2 ITPR1 ADCY4 ADCY3 ITPR2 ADCY2 ITPR3 ADCY1 ADCY8 ADCY7 PRKCZ ADCY6 ADCY5 GNA14 PRKAR2B PRKAR2A GNA11 MAPK1 MAPK3 NOS3 ADCY10 GNAL GNAQ GNAS ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release GNB3 GNB5 OPRD1 GNAI3 CREM PRKX ADCY2 ADCY7 GNAI1 GNAI2 GNG10 GNG3 GNGT2 GNG2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG PENK GNG8 PRKACA PRKACB OPRM1 PDYN GNG12 GNAO1 CREB1 GNAL GNB2 GNB1 GNB4 FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway FAF1 CAPG FASLG LMNB2 LMNB1 CASP9 MAPK9 MAPK8 CASP7 CASP8 SCIN CASP6 CASP10 CASP3 LMNA FADD MAP3K5 DFFB MAP2K4 JUN DAXX PARP3 GSN PARP4 APAF1 PARP1 PARP2 CFLAR MAPK10 FAS FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway SPRY2 SPRY1 PTPN6 GRAP FGFR4 FGFR3 FGFR2 FGFR1 ARAF PIK3CD PEBP1 PIK3CB PIK3C2A PIK3CG PIK3C2B AKT2 AKT3 RAC2 AKT1 RAC1 MAP3K6 HRAS MAP3K4 MAP3K5 PRKCG MAP2K3 MAP2K4 PRKCI MAP2K1 RASA4B PRKCH MAP2K2 PRKCB PRKCE PRKCD PRKCA FRS2 FRS3 PIK3CA RASA4 RASA1 RASA2 PRKCQ PIK3C3 RAF1 SOS1 SOS2 SHC3 SHC1 PRKCZ MAPK9 NRAS MAPK8 PLCG2 MAPK1 PLCG1 MAP2K7 MAPK3 MAP2K6 MAP3K2 MAP3K3 SPRY4 MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 SPRY3 FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis FLAD1 RFK FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis DHFR DHFR2 MTHFD1L MTHFD2 MTR TYMS FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism HK1 KHK GALE GALT HKDC1 ALDOC ALDOB ALDOA HK2 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling PRKAR1B PRKAR1A GNB2 GNB1 GNB4 GNB3 GNAI3 CACNA1B ADCY4 CACNA1A ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 GNAI1 CACNA1G ADCY5 GNG3 GNGT2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNG8 PRKACA PRKACB KCNJ3 GABBR2 GABBR1 GNG11 GNAO1 ADCY9 GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis ALDH5A1 GAD1 GAD2 ABAT CSAD GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation GTF2A1 GTF2A2 GTF2B TAF9 TTF1 GTF2E1 GTF2E2 TAF1C POLR2C POLR2F POLR2H TAF9B CFAP20 GTF2A1L BRF2 TAF12 BRF1 MTERF2 TAF11 GTF2H1 GTF2F1 GTF2H3 GTF2F2 GTF2H4 TAF8 TBPL1 TAF7 TAF6 TAF4 TAF2 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I TBP RRN3 CAVIN1 TTF1 PSMC3IP TAF1B TAF1C TBPL2 POLR1B TAF1A POLR1D UBTF TAF8 TBPL1 POLR2K GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion GLUD1 GLUD2 LGSN GLUL GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis GAPDH PFKM GPI TPI1 PKLR PGAM2 ENO1 BPGM ENO2 HK2 HK1 PFKL PKM HKDC1 PGK1 PGAM4 ALDOA UNTITLED%PANTHER PATHWAY%P06664 untitled TGIF1 SKIL RELA HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway SUFU GLI1 BTRC GLI3 SHH CREBBP SMO STK36 FBXW11 PTCH1 HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis HMBS RSAD1 CPOX PPOX COX10 EARS2 ALAD EPRS1 FECH QARS1 UROD HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 HTR4 HTR6 HTR7 CREB3L3 CREB3L4 ADORA3 PRKACG CREB3L1 CREB3L2 ADORA1 EP300 PRKACA PRKACB PHKA1 PHKA2 MTNR1A ADCY9 PRKAR1B PRKAR1A MTNR1B CREM ADRB1 ADRB2 RAP1B HRH1 GNG10 RAP1A HRH3 HRH2 PRKAR2B PRKAR2A CLTCL1 HRH4 DRD1 DRD2 DRD4 DRD5 CREBBP HTR1E HTR1F HTR1D HTR1A HTR1B PHKB GNG12 GNAL GNB2 GNB1 CALM1 PYGB GSK3B GSK3A CLTC CLTB HTR2B CLTA HTR2C PYGM ADRA1D PYGL HTR2A ADRA1B ADRA1A GRM1 GYS2 GNGT1 GRM3 GYS1 GRM2 GRM5 GNGT2 GRM4 GRM7 GRM6 GRM8 GNRHR SSTR1 OPRM1 ADRA2C SSTR2 ADRA2B SSTR3 SSTR4 SSTR5 CREB3 CREB1 ADRB3 ADORA2A ADORA2B CREB5 OPRD1 GNAI3 OPRL1 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 GNAI1 ADCY5 GNAI2 GNG3 GNG2 GNG5 PHKG1 GNG4 GNG7 PHKG2 GNG8 KCNJ3 KCNJ5 KCNJ6 KCNJ9 OPRK1 GPR50 HTR5A HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway ADORA2B PRKCQ ARHGEF1 PLCB1 PLCB2 OPRD1 GPR45 OPRL1 CACNA1B ITPR1 CACNA1A ITPR2 ITPR3 RASGRP2 RASGRP1 PRKCZ CACNA1E DNAJC27 RAP1GAP RASGRP4 RASGRP3 RAP1B GNA14 GNG10 GNG3 GNG2 RAP1A GNG5 GNG4 GNG7 GNA11 CLTCL1 GNG8 DRD1 DRD2 DRD4 DRD5 OPRK1 GNG12 GNG13 GNAO1 GNAQ GNB2 GNB1 GNB4 GNB3 CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 CLTC CLTB CLTA GRM1 GNGT1 GRM3 GRM2 GRM5 GNGT2 GRM4 GRM7 GRM6 ADORA3 GRM8 BDKRB2 ADORA1 GNRHR BDKRB1 GARNL3 PRKCG PRKCI PRKCH PRKCB PRKCE PRKCD PRKCA SSTR1 OPRM1 SSTR2 SSTR3 SSTR4 RHOA SSTR5 PLCB3 PLCB4 ADORA2A HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction CALML3 PDC GNGT1 GRK1 GNG10 GNG3 GNGT2 GNG2 GNG5 GNG4 GNG7 RHO CNGA1 GNG8 PDE6B CNGA3 GNAT1 PDE6A RGS9 RCVRN PDE6G GNG12 GNG13 GNB2 GNB1 GNB4 CNGB3 GNB5 CALM1 CNGB1 HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway PRKCE PLCL1 PRKCD PRKCA GNG12 PLCB3 PLCB4 GNAQ GNB2 GNB1 GNB4 GNB3 PRKCQ GNB5 PLCB1 PLCB2 PLCD4 PLCD1 ITPR1 ITPR2 ITPR3 PRKCZ GNA14 HRH1 GNG10 GNG3 GNGT2 GNG2 GNG5 PLCZ1 GNG4 GNG7 GNA11 PLCG2 PLCE1 GNG8 PLCG1 PRKCG PRKCI PRKCH PRKCB HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway GNG2 GNG5 HRH2 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 PRKACA PRKACB PRKX ADCY2 GNG12 ADCY7 GNG10 GNG3 GNGT2 GNAL HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis HDC HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease CYFIP2 CYFIP1 ARPC5L ACTB ACTG2 ACTG1 TUBB8 TUBB6 CAPN9 CAPNS1 CAPN6 TUBB3 CAPNS2 CAPN7 CAPN5 TUBB1 CAPN2 CAPN3 EP300 CAPN1 TP63 DYNC2H1 MAP2K4 DYNC1LI1 DYNC1LI2 GAPDHS TP53 KALRN GRIN2A CYC1 MAP2K7 JUN CREBBP BDNF ARPC5 GRIN2C GRIN2B GRIN2D GRIN3A SP1 DLG4 MAP3K10 DNAL4 TP73 HIP1 ARPC1B GRIK5 ARPC1A CLTB GRIK3 GRIK4 AP2A1 GRIK1 GRIK2 AP2A2 CASP8 CASP3 RAC2 RAC1 IFT57 ACTR2 DNAI2 TBP APAF1 TUBB RHOG FOS DYNLL1 DYNLL2 ACTA2 ACTA1 TUBB2B TUBB2A ACTBL2 RHOJ HAP1 GAPDH RHOQ DNAH3 DYNC1I2 DNAH7 DCTN1 DNAH8 DNAH5 HTT CDC42 MAPK9 DYNC1I1 DYNC1H1 HIP1R TUBB4B TUBB4A GRIN1 CAPN11 ACTC1 CAPN12 CAPN10 TAF4 HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation EGLN1 CREBBP EGLN3 EGLN2 RORC ARNT TXN HIF1A MTOR TXN2 AKT2 AKT3 AKT1 VHL INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway CX3CL1 IKBKB PLCZ1 RAC2 CCR9 CCR8 ITGB7 CCR7 CCR6 RAC1 JAK2 CCR5 CCR4 PF4V1 CCR3 CCR2 CHUK VWF PDPK1 RHOG RHOC VAV1 RHOA ACTA2 MYH1 ACTA1 PLCB3 MYH2 MYH3 PLCB4 IFNG PIK3CA ACTBL2 MYO3B COL6A2 COL6A1 MYO3A MYH8 COL6A3 MYH9 SOS1 PLCB1 MYH4 PLCB2 MYH6 MYH7 CX3CR1 NFAT5 CCL13 CAMK2D CCL11 ROCK1 CAMK2A GNAI3 CXCR5 CXCR4 PRKX ADCY2 CXCR6 ADCY6 GNAI1 RELA ADCY5 GNAI2 RELB CDC42 GNA14 NRAS GNG3 PAK1 GNG2 CCL8 CXCR1 GNG5 CCL7 GNG4 GNG7 CCL5 GNA11 CXCR3 CCL4 CXCR2 CCL3 CCL2 MAPK1 PTK2B PAK6 GNG8 PAK3 CCL18 PAK2 PAK5 PAK4 MAPK3 CCL22 CCL21 CCL20 PLCL1 STAT3 ACTC1 KRAS PLCD4 PLCD1 CCL27 PF4 CCL26 MYLK2 CCL4L2 COL12A1 ARAF ARPC5L ACTB ACTG2 MYLK3 ACTG1 MYLK PREX1 PRKACG AKT2 CCRL2 AKT3 AKT1 PLCE1 PRKACA JUNB PRKACB PRKCB PRKCE CASK LTB4R2 RAF1 IFNAR1 SHC1 CCL3L3 C5AR1 FPR1 ITPR1 ITPR2 FPR3 ITPR3 PRKCZ GNG10 RRAS PLCG2 MYH13 MYH14 MYH11 PLCG1 MYH10 CCR10 CCR1 MYH7B JUN JUND XCR1 NFATC3 NFATC2 NFATC1 ARPC4 ARPC5 GNG12 IL2 NFKB2 NFATC4 GNAO1 CXCL10 ARPC2 ARPC3 GNAQ COL20A1 GNB3 GRAP ITGB1 CXCL8 COL14A1 ARPC1B ARPC1A PIK3CD PIK3CB ITGAL PIK3CG INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade IRS1 IRS4 IRS2 ELK1 INS IGF1R RPS6KA4 RPS6KA3 RPS6KA6 RPS6KA5 RPS6KA2 RPS6KA1 MAPK1 MAPK3 MAP2K3 MAP2K1 MAP2K2 INSR INSRR IGF2 FOS IGF1 IGF2R RPS6KB1 RASA1 RPS6KB2 RAF1 SOS1 SOS2 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade TPTE TSC1 IRS2 IGF1 FOXO3 IGF2R FOXO1 INS IGF1R PIK3CA MDM2 MDM4 GSK3B GSK3A PDPK1 IRS1 INSR INSRR IRS4 IGF2 PTEN TSC2 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway ITGB8 COL10A1 ITGAV ITGB7 ITGB6 RAC1 HRAS ITGA4 ITGA3 ITGA2 ITGA1 RHOC RHOA ARFGAP1 RHOB RAP2C ARHGAP10 RAP2A COL2A1 RAP2B PIK3CA ITGAD ACTBL2 COL6A2 COL6A1 ITGA8 RAPGEF1 COL6A3 ITGA7 ITGA6 PIK3C3 ITGA5 SOS1 CRK SOS2 DOCK1 ARF6 ITGA9 LAMA5 COL15A1 LAMA2 SRC LAMA1 COL11A1 LAMA4 COL11A2 LAMA3 NTN4 ASAP1 CDC42 MAPK9 NRAS MAPK8 MICALL1 FLNA PTK2B FLNB FYN CSK MAPK6 MAPK3 MAP3K2 MAP3K3 LAMB3 LAMB2 LAMB4 LAMB1 PTPN12 MAPK13 MAPK10 COL3A1 BCAR1 LIMS2 LIMS1 COL16A1 ITGA2B COL12A1 ARAF ARPC5L ACTB CRKL ACTG1 DMBT1 MAP3K4 MAP3K5 MAP2K3 MAP2K4 MAP2K1 MAP2K2 COL27A1 ACTN2 ACTN1 ACTN4 COL4A2 COL4A1 COL4A4 COL4A3 COL8A2 COL4A6 ELMO1 COL8A1 COL4A5 ELMO2 RAF1 TLN1 VCL COL17A1 COL13A1 SHC1 PXN ARL1 PIK3R3 PIK3R2 PIK3R1 DNAJC27 RAP1B RAP1A RRAS VASP CAV1 FN1 BRAF PARVA ARPC5 PARVB ARHGAP26 PTK2 COL1A2 ARPC2 COL5A1 ARPC3 ITGA10 COL5A3 COL5A2 ITGA11 COL9A1 COL20A1 ITGBL1 COL9A3 COL9A2 ITGB1 ARF1 ITGAM ITGB5 ITGB4 COL14A1 LAMC3 ARPC1B ITGB2 ARPC1A PIK3CD ILK LAMC2 LAMC1 ITGAE PIK3CB PIK3C2A ITGAL RND2 RND3 PIK3CG PIK3C2B RND1 RAC2 ITGAX INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway IFNG IFNGR1 STAT1 IFNGR2 JAK2 JAK1 INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway IL3RA MAPKAPK2 RAF1 IL6ST SOS1 SOS2 SHC1 SRF IL20RA FOXO3 NRAS MAPK7 CXCR1 MKNK1 CXCR2 MKNK2 STAT4 MAPK1 STAT6 IL12RB1 MAPK6 MAPK3 IL12RB2 STAT5A STAT5B NOS3 STAT1 IL10RB STAT2 IL10RA STAT3 BRAF MAPK15 MTOR IL2 IL4 IL6 IL5 IL7 IL2RA IL2RB IL9 IL21 GSK3B CDKN1A CXCL8 SPI1 CDKN1B IRS1 ARAF IL5RA IRS2 PIK3CB SLA2 ELK1 ELK3 IKBKB ELK4 RPS6KA3 SPIC RPS6KA6 MYC AKT2 RPS6KA2 RPS6KA1 AKT3 AKT1 IL13RA2 IL6R JAK3 IL13RA1 IL10 IL11 IL15RA IL4R CHUK PDPK1 IL15 IL11RA IL13 IL18 FOS IL1A PIK3CA IL23A IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway GRIN3A VAMP1 SHANK3 VAMP2 VAMP3 SHANK1 GRIA1 GRIA2 SNAP25 GRIK5 STX19 SNAP23 SLC1A1 SLC1A2 GRIK3 SLC1A3 GRIK4 GRIK1 GRIK2 SLC1A6 SLC1A7 STX11 GRM3 GRM2 GRIN2A SLC17A6 SLC17A8 SNAP29 GRIA3 GRIA4 GRIN2C GRIN2B GRIN2D GRIN1 VAMP8 ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis HACL2 BCAT1 BCAT2 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway JAK3 JAK1 STAT5A STAT5B STAT1 STAT3 STAT4 STAT6 JAK2 LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis BCAT1 BCAT2 LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis LIAS MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism GMPPB GMDS PMM1 PMM2 MPI GMPPA METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway GNB3 GNB5 SNAP25 GRIK5 SNAP23 GRIK3 GRIK4 GRIK1 GRIK2 GRM1 GRM5 GNGT2 GRM4 GRM7 GRM6 PRKACG GRM8 PRKACA SNAP29 PRKACB CACNB1 VAMP8 STX1B PRKAR1B PRKAR1A VAMP1 VAMP2 STX1A VAMP3 GRIA1 GRIA2 SLC1A1 GNAI3 SLC1A2 CACNA1B CACNA1A SLC1A3 PRKX SLC1A6 SLC1A7 CACNA1E GNAI1 GNAI2 GNG10 GNG3 GRIN2A GNG5 PRKAR2B GNG4 GNG7 PRKAR2A VTI1A GNG8 SLC17A7 GRIA3 GRIA4 GRIN2C GRIN2B GRIN2D GRIN1 ADCY10 GRIN3A GNB2 GNB1 GNB4 METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway PRKACA SNAP29 PRKACB GNG11 GNAO1 CACNB1 VAMP8 STX1B ADCY10 PRKAR1B PRKAR1A GNB2 GNB1 GNB4 GNB3 VAMP1 GNB5 VAMP2 STX1A VAMP3 SNAP25 SNAP23 GNAI3 CACNA1B CACNA1A PRKX CACNA1E GNAI1 GNAI2 GRM3 GRM2 GNG10 GNG3 GNGT2 GNAT2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNG8 METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway GRIN2D GRIN1 GRM5 GRIN2A PLCB4 GRIN3A PRKAR1B PRKAR1A PRKACG GNA11 GNAQ PRKACA PRKACB GRINA HOMER1 PRKCB GRIK5 ITPR1 GRIK1 PRKX GRIN2C GRIN2B GRM1 METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis MTR METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle IREB2 ACO1 METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway MCEE PCCA PCCB MMUT MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing ZRSR2 SNRNP40 PRPF3 ZRSR2P1 SNRPB2 SNRPA MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway PRKCE PRKCD PRKCA GRIN2C GNG11 GRIN2B GRIN2D GRIN1 SLC5A7 PLCB4 GRIN3A GNAQ GNB2 GNB1 GNB4 GNB3 PRKCQ PKN2 GNB5 PKN1 CHRM3 CHRM1 PKN3 ITPR1 ITPR2 ITPR3 PRKCZ GNA14 GNG10 GNG3 GRIN2A GNGT2 GNG5 GNG4 GNG7 GNA11 GNG8 SLC18A3 PRKCG PRKCI PRKCH PRKCB MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway ADCY10 SLC5A7 SLC6A8 PRKAR1B PRKAR1A GNB2 GNB1 GNB4 GNB3 GNB5 CHRM2 CHRM4 GNAI3 PRKX GNAI1 GNAI2 GNG10 GNG3 GNGT2 GNAT2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNG8 GNAT1 PRKACA PRKACB KCNJ3 SLC18A3 KCNJ5 KCNJ6 KCNJ9 GNG11 GNAO1 N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism GNPDA1 GNPDA2 GFPT2 AMDHD2 GFPT1 NPL NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation INMT UGT2B7 CYP2A7 CYP2A6 CYP2A13 UGT1A5 UGT1A4 UGT1A3 FMO3 NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway CLIC6 CHRNA3 CHRNA5 KCNK9 EPB41 CHRNA4 CHRNA6 ADCY2 CACNA1C GNAI1 CACNA1G GNG2 EPB41L1 EPB41L2 FLNA DRD2 PRKACA DRD4 SLC18A2 CHRNB2 CHRNB4 CHRNB3 PPP1CA GNB1 PPP1R1B KCNK3 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway MYO1E MYO1B MYO1C SLC6A8 ACTC1 MYO1A MYO15A MYO5B MYO5C CHRFAM7A MYO1F MYO1G SLC44A3 ACTB ACTG2 ACTG1 ACTR1A ACTR1B MYO18B MYO18A SLC18A3 CHRNB2 CHRNB1 CHRNB4 CHRNB3 MYH15 MYO7B MYO7A ACTA2 MYH1 ACTA1 SLC5A7 MYH2 MYH3 ACTBL2 MYO3B CTAGE4 MYO3A CTAGE9 MYH8 MYH9 MYH4 MYH6 CTAGE15 MYH7 CHRNA1 CHRNA3 CHRNA2 PLEKHH3 CHRNA5 CHRNA4 CHRNA7 CHRNA6 CHRNA9 CHRND CHRNG CHRNE MYO6 MYH13 MYH14 CHRNA10 MYH11 MYH10 MYH7B MYO10 MYO5A MYO9A MYO19 MYO16 MYO1D NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway NOTCH2 RBPJL JAG2 NOTCH3 NOTCH1 JAG1 MAML1 NOTCH4 RBPJ DLK1 DLL3 DLL4 NCOR2 NUMB CIRSR O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis TGDS GFPT2 GFPT1 UNTITLED%PANTHER PATHWAY%P05916 untitled GNAI2 GNAO1 GNG10 GNG3 GNGT2 GNG2 GNG5 GNG4 GNG7 GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 AVP GNAI3 OPRK1 OXT ADCY2 PDYN GNG12 ADCY7 GNAI1 OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway GNGT2 GNG2 GNG5 GNG4 GNG7 GNB2 PENK GNB1 GNB4 GNB3 GNG8 GNB5 OPRD1 GNAI3 ADCY2 PDYN GNG12 ADCY7 GNAI1 GNAI2 GNG10 GNG3 OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway GNG3 GNGT2 GNG2 GNG5 GNG4 GNG7 GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 OPRD1 GNAI3 ADCY2 GNG12 ADCY7 GNAI1 GNAI2 POMC GNAO1 GNG10 ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation ODC1 AZIN2 AZIN1 OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response MAPK12 MAPK13 MAPK9 MAPK11 MAPK8 EEF2K MYC DDIT3 MKNK1 MKNK2 BCL2 MAP2K6 MAP2K3 MAP2K4 JUN MEF2C STAT1 MAX PLA2G4A TXN MAPK14 ELK1 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway PLCB4 GNAQ GNB2 GNB1 GNB4 GNB3 PRKCQ GNB5 PLCB1 PLCB2 PLCD4 PLCD1 OXTR PRKCZ GNA14 GNG10 GNG3 GNGT2 GNG2 GNG5 PLCZ1 GNG4 GNG7 GNA11 PLCG2 PLCE1 GNG8 PLCG1 PRKCG PRKCI PRKCH PRKCB PRKCE PLCL1 PRKCD PRKCA GNG12 PLCB3 P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway ATF1 SRF HSPB1 ELK1 RPS6KA4 EEF2K RPS6KA5 MKNK1 MKNK2 MAP3K7 EIF4E MEF2D MAP3K4 MAP2K6 MAP2K4 MEF2C MEF2B IL1R1 MAPK14 MAPK12 MAPK13 MAPK11 MAPKAPK3 TRAF6 MAPKAPK2 MAP3K10 TAB2 TAB1 P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation AKT2 RPS6KB2 AKT3 EIF4EBP1 AKT1 TP53 TP63 TP73 IGBP1 PRKAB2 PRKAA1 PRKAA2 PRKAG1 TSC2 TSC1 PRKAB1 PPP2CA PPP2CB RPS6KB1 RHEB P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 COP1 MDM2 MDM4 TP53 TP63 TP73 P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 MAPK14 MAPK12 MAPK13 MAPK11 RBL1 PIK3CA CCNE1 CDK2 CCNG1 CTNNB1 KRAS ATM PIK3C3 TP53 TP73 ATR RB1 CDKN1A PTEN PIK3CD PIK3R3 PIK3R2 PIK3C2G TPTE PIK3R1 PIK3CB PIK3C2A PIK3CG PIK3C2B PIK3R5 PPP2CA PPP2CB NRAS AKT2 AKT3 AKT1 HRAS TP63 PDPK1 SIAH1 P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway CREBBP GADD45B PDPK1 GADD45A CDKN2A TRAF2 CDC25C SIRT1 PML GADD45G KAT2B PIK3CA CCNE1 KAT6B CDK2 CDK1 MDM2 MDM4 ATM TP53 TP73 ATR CDKN1A HDAC1 PTEN TPTE HMGB1 CCNB1 WRN SUMO1 SIN3A CHEK2 AKT2 SUMO3 SUMO2 AKT3 AKT1 EP300 SFN MTA2 GTSE1 TP63 CDKN2D PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease MAPK1 SFN NDUFV2 YWHAG MAPK3 SNCA YWHAH GPR37 SEPTIN1 SEPTIN2 STX7 SEPTIN5 CASK SEPTIN4 GPR37L1 MAPK14 SNCAIP YWHAZ MAPK15 MAPK12 PSMA5 MAPK10 PSMA6 PSMA3 PSMA4 CCNE2 TH PSMA1 CCNE1 PSMA2 PRKN YWHAE STX12 YWHAB ELK1 PSMA7 PSMB10 SLC6A3 PLD2 PSMA8 MAPK9 PSMB7 MAPK8 MAPK7 YWHAQ PSMB3 PSMB1 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway EHF ARAF ETS1 ELK1 RPS6KA4 ELK4 RPS6KA3 ARHGAP42 RPS6KA6 RPS6KA5 OPHN1 GRAP2 MYC AKT2 RPS6KA2 RPS6KA1 MAP3K4 PDGFRB PDGFRA MAP2K1 MAP2K2 PRKCA PDGFRL MAPKAPK2 ERF ERG RAF1 SHC2 SHC3 SHC1 PDGFB ITPR1 PDGFA ITPR2 PIK3R3 PIK3R2 ITPR3 PIK3R1 ARHGAP15 ARHGAP12 PIK3R5 PLCG2 SRGAP3 PLCG1 SRGAP1 STAT5A STAT5B JUN BRAF ARHGAP26 FLI1 FEV GRB2 GRAP ARHGAP9 GSK3B GSK3A ARHGAP8 ARHGAP1 PIK3CD PIK3CB ARHGAP5 ARHGAP6 PIK3CG RERG ARHGAP4 IKBKB NCK2 JAK2 HRAS JAK3 NINL GABPA NCK1 JAK1 VAV3 RASA4B CHUK PDPK1 GAB1 FOS GAB2 ETV3 VAV1 VAV2 ARHGAP10 ELF1 ELF2 PIK3CA ELF3 RASA4 ELF4 RASA1 ELF5 RASA2 PIK3C3 SOS1 SOS2 MYCBP SRF NRAS MAPK8 MAPK7 RPS6KC1 MKNK1 MKNK2 STAT4 MAPK1 STAT6 MAPK6 SPDEF MAPK3 MAP3K2 STAT1 STAT2 STAT3 ELP1 USF2 MAPK15 RAB11B MAPK10 NIN RPS6KB1 RPS6KB2 PKN2 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway RPIA GPI HKDC1 TALDO1 TKT PGD HK2 HK1 PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation AOC3 AOC1 AOC2 PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway NOS3 INSR YWHAZ RPS6KB1 PIK3CA GNAQ GNB2 GNB1 RPS6KB2 GNB4 GNB3 GNB5 SOS1 SOS2 GSK3B PTGER1 IRS1 GNAI3 PIK3R3 PIK3R2 PIK3R1 PIK3CB FOXO4 FOXO3 GNAI1 FOXO1 GNAI2 PIK3R5 CASP9 GNGT1 GNA14 NRAS GNGT2 GNAT2 GNA11 AKT2 AKT3 AKT1 PDPK1 PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade FGB FGA SERPINB2 MMP1 FGG SERPINE1 MMP3 SERPINF2 PLAUR PLG PLAT MMP9 MMP13 PLAU LPA PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism NT5E GDA AMPD3 XDH PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis PSAT1 PNPO PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway PDXK PNPO PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism DPYD DPYSL3 ABAT UPB1 CDA NT5E ALDH6A1 DPYSL5 DPYS DPYSL2 PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism PKLR ME1 PCK1 CLYBL CS ACLY PDHA2 PDHA1 PC PKM RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway STAT3 BRAF MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 KRAS GRB2 RGL1 ATF2 GSK3B GSK3A ARAF MAP3K7CL PIK3CD PIK3CB ETS1 ELK1 PIK3CG RPS6KA3 RPS6KA6 RPS6KA2 RPS6KA1 AKT3 RAC2 AKT1 RAC3 RAC1 HRAS MAP3K4 MAP2K3 MAP2K4 MAP2K1 MAP2K2 PDPK1 RHOC RHOA RHOB TIAM1 PIK3CA MAPKAPK3 MAPKAPK2 PIK3C3 RAF1 SOS1 SOS2 EXOC2 RALA RALB SHC1 SRF PLD1 PLD2 CDC42 MAPK9 NRAS MAPK8 PAK1 MAPK1 MAP2K7 PAK3 RALGDS PAK2 MAPK3 MAP2K6 JUN MAP3K1 STAT1 S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis MAT2A MTR MAT1A SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides CDA TK1 ADAT2 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides UPRT UPP1 ADAT2 UCKL1 UCK2 UCK1 NME2 NME3 NME4 UPP2 SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis PSAT1 PHGDH PSPH SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion PCCB ECHDC1 MMUT SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking SYT6 STX1B RIMS1 SYT12 SYT11 VAMP1 STX2 STX1A SYT5 UNC13B SNAP25 UNC13C SYT3 RAB3A SYT2 SYT1 STXBP1 SYT15 SYT7 UNC13D TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle SUCLG1 SDHC ACO2 PDK2 CS FH PDHA2 PDHA1 MDH1 OGDH T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation CD86 CD80 ARAF PIK3CD CD3G PIK3CB CD3E CD3D PIK3CG IKBKB PPP3CA PPP3CB PPP3CC GRAP2 AKT2 AKT3 NCK2 AKT1 RAC1 HRAS NCK1 VAV3 MAP2K1 MAP2K2 CHUK FOS VAV1 VAV2 ZAP70 PIK3CA LCK PRKCQ LCP2 PIK3C3 RAF1 SOS1 SOS2 ITPR1 PIK3R3 PIK3R2 PIK3R1 CDC42 MAPK9 NRAS MAPK8 PAK1 MAPK1 PLCG1 PAK3 PAK2 MAPK3 JUN MAP3K1 BRAF NFKBIA PTPRC CD28 CD247 CALM1 LAT TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis DHFR DHFR2 GCH1 FPGS TYMS TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway SMURF1 BMP8A GDF2 SMAD9 GDF1 BMP8B INHBB INHBA GDF3 SMAD6 MAPK14 GDF6 BMP7 GDF5 INHBC ACVR2B SMAD5 BMP6 ACVR2A MAPK12 SMAD7 MAPK13 BMP5 INHBE GDF7 BMP4 SKI FOSL1 MAPK10 GDF9 BMP3 MAPK11 BMP2 BMP1 GDNF TLL2 TLL1 TAB1 BMPR1B NODAL BMPR1A DCP1B ACVRL1 ATF2 BMP10 BMPR2 MSTN AMHR2 CITED1 CITED2 MAP3K7CL BMP15 EP300 SNIP1 MAP3K7 HRAS JUNB ACVR1 LEFTY1 FOXH1 TGFBR1 TGFBR2 ACVR1B MAPK9 NRAS MAPK8 ACVR1C RRAS MAPK1 LEFTY2 SKIL MAPK3 GDF10 SMAD2 GDF11 SMAD1 JUN TGFB2 SMAD4 CREBBP JUND SMAD3 SMURF2 TGFB3 GDF15 THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism THTPA TPK1 THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis THNSL1 THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway SNAP25 SNAP23 TRH GNGT2 PLCZ1 PLCE1 SNAP29 TSHB PRKCG PRKCI PRKCH PRKCB PRKCE PRKCD PRKCA TRHR CACNB1 VAMP8 CACNB2 CACNB3 PLCB3 CACNB4 PLCB4 VAMP1 PRKCQ PLCB1 PLCB2 VAMP2 VAMP3 CACNA1B CACNA1A PRKCZ CACNA1E GNA14 GNG10 GNG3 GNG2 GNG5 GNG4 GNG7 GNA11 PLCG2 GNG8 PLCG1 STX3 CGA PLCL1 GNG12 GNAQ GNB2 GNB1 GNB4 GNB3 GNB5 PLCD4 PLCD1 TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway TLR8 TLR10 TLR7 TAB1 TLR6 NFKBIE TLR4 TLR3 MYD88 TLR2 ECSIT ELK1 TANK IKBKB MAPK9 MAPK8 TBK1 IRAK1 MAP3K8 MAP3K7 IKBKE MAPK3 MAP2K3 JUN MAP2K1 MAP2K2 TICAM2 CHUK IRAK4 MAPK14 TICAM1 TIRAP NFKBIA IRF3 TOLLIP TRAF6 TLR9 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor POLR2E POLR2F EP300 POLR2H TAF9B CFAP20 POLR2L GTF2A1L CREBBP TBP BRF2 TAF12 BRF1 MTERF2 TAF11 GTF2H1 GTF2F1 GTF2H3 GTF2F2 GTF2H4 PRKAR1B PRKAR1A TBPL2 TAF8 TBPL1 TAF7 TAF6 TAF4 TAF2 CREB5 GTF2A1 GTF2A2 GTF2B TAF9 TTF2 TTF1 GTF2E1 GTF2E2 PSMC3IP CREB3L3 PRKAR2B TAF1C CREB3L4 PRKAR2A POLR2C CREB3L1 CREB3L2 TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism LIPE LIPC UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway UBA7 UBE2D4 UBA6 UBE2D2 UBE2D3 UBE2D1 UBE2L6 UBE2L3 UBE2NL ATG7 UBE2B UBE2C UBE2E3 UBE2E1 UBE2E2 UBE2G1 UBE2A UBE2G2 UBE2S UBE2T UBE2N UBE2V2 UBA3 UBA2 UBA1 SAE1 UBE2K VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis HACL2 BCAT1 BCAT2 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis OXT AVP VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway PRR5 ARHGAP8 TGFB1I1 ARAF ARHGAP1 PIK3CD HSPB1 PIK3CB PIK3C2A ETS1 PIK3CG PIK3C2B CASP9 RAC2 KDR AKT1 RAC3 RAC1 HRAS PRKCG PRKCI MAP2K1 PRKCH MAP2K2 PRKCB SPHK2 PRKCE SPHK1 PRKCD PLA2G4A PRKCA PIK3CA MAPKAPK3 PRKD3 MAPKAPK2 PRKCQ PIK3C3 PRKD2 PRKD1 CRYAA RAF1 CRYAB SHC2 SH2D2A PXN PIK3R3 PIK3R2 PIK3R1 PRKCZ HIF1A NRAS PLCG2 LPXN MAPK1 PLCG1 MAPK3 NOS3 BRAF MAPK14 PTK2 VEGFA VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism PDXK PSAT1 PNPO VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway RXRA VDR RARA F13B GC WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway SMARCAL1 SMARCB1 FZD10 ARR3 BTRC PRKCG PRKCI SMARCC1 PRKCH SMARCC2 PRKCB PRKCE CSNK2A3 CSNK2A2 PRKCD PRKCA CSNK1D CSNK1E CSNK2B PRKCQ SRCAP PCDH10 PCDH15 PCDH12 PCDH19 NLK PRKCZ PCDH18 GNG10 PPP3R1 PPP3R2 PCDHA1 HLTF PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA9 PCDHA8 PCDHA7 PCDHA6 FZD1 WNT10B CREBBP WNT10A FZD3 FZD2 FZD5 FZD4 SIAH2 FZD7 PCDH20 FZD6 SIAH1 FZD9 SMARCA5 NFATC3 NFATC2 FZD8 NFATC1 INO80 SMARCA1 GNG12 SMARCA2 SMARCA4 NFATC4 GNG13 PCDHGA10 PCDHGA11 PCDHGA12 PCDHB2 PCDHB1 FAT1 PCDHB6 FAT2 PCDHB5 FAT3 DCHS1 PCDHB4 PCDHB3 PCDHB8 PCDHB7 PPP3CA PPP3CB PPP3CC ANKRD6 HELLS WNT9B KREMEN1 WNT9A KREMEN2 PLCB3 PLCB4 PLCB1 PLCB2 WNT8A WNT8B FSTL1 PPP2CA PPP2CB CTNNA1 TBL1Y CTNNA3 TBL1X CTNNA2 CSNK1A1 WNT7B PCDHB15 WNT7A PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB10 PCDHB16 CTNNB1 PCDH11Y PCDH11X CELSR1 CELSR2 CDH9 CDH8 CELSR3 CDH7 CDH6 CDH5 CDH4 CDH3 CDH2 CDH1 EP300 PCDHAC2 PCDHAC1 TLE4 TLE3 CSNK1G3 TLE2 TLE1 WNT5B FBXW11 WNT5A CHD1L PCDHA13 PCDHA12 PCDHA11 TLE6 PCDHA10 PYGO1 PYGO2 TBL1XR1 CSNK1G2 ITPR1 ITPR2 ITPR3 WNT6 CDH20 DVL1 CDH22 DVL2 EP400 CDH23 CDH24 DVL3 WNT1 WNT2 WNT3 WNT4 SMAD1 SMAD4 WNT3A SMAD5 BCL9 GNAQ GNB2 GNB1 GNB4 GNB3 GSK3B PCDHGB7 WNT2B PCDHGB6 PCDHGB4 PCDHGB2 ARRB1 ARRB2 PPP2R5E DACT1 PCDHGA8 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA3 PCDHGA2 PCDHGA1 AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C ARID1A WNT16 CDHR1 CDH10 CDH11 CDHR2 SAG CDH12 PCDHGB1 CDH13 CDH15 CDH16 CDH17 CDH18 CDH19 SMARCD1 HDAC2 SMARCD2 HDAC3 SMARCD3 HDAC1 LEF1 LRP5 HDAC8 LRP6 GNA14 GNG3 WNT11 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 PCDH1 CTNNAL1 SMARCE1 TCF7L2 TCF7L1 PCDH9 PCDHGC5 PCDH7 PCDHGC4 PCDH8 PCDHGC3 CSNK1A1L XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway PNP GDA HPRT1 PRTFDC1 ALANINE METABOLISM%SMPDB%SMP0000055 Alanine Metabolism PC AARS2 MPC1 GPT AGXT ASPARTATE METABOLISM%SMPDB%SMP0000067 Aspartate Metabolism ADSL GAD1 CAD ASNS ABAT ASS1 DARS1 ASRGL1 DDO IL4I1 NARS1 ASL ADSS1 ASPA GLUTAMATE METABOLISM%PATHWHIZ%PW000003 Glutamate Metabolism ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT GLUTATHIONE METABOLISM%SMPDB%SMP0000015 Glutathione Metabolism GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 CITRIC ACID CYCLE%SMPDB%SMP0000057 Citric Acid Cycle CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 ALPHA LINOLENIC ACID AND LINOLEIC ACID METABOLISM%PATHWHIZ%PW000006 Alpha Linolenic Acid and Linoleic Acid Metabolism FADS2 ELOVL4 ELOVL5 PLA2G4B FADS1 SELENOAMINO ACID METABOLISM%PATHWHIZ%PW000007 Selenoamino Acid Metabolism MARS1 METTL6 SLC39A8 SCLY MAT2B GGT1 SEPHS2 PAPSS1 AHCY MAT2A CBS CTH AMINO SUGAR METABOLISM%PATHWHIZ%PW000008 Amino Sugar Metabolism NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 AMMONIA RECYCLING%PATHWHIZ%PW000009 Ammonia Recycling GLDC GLS2 AQP8 AMT ASNS PIG59 DLD ASRGL1 GLUD1 HAL SDS CPS1 ARGININE AND PROLINE METABOLISM%SMPDB%SMP0000020 Arginine and Proline Metabolism EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO BETA-ALANINE METABOLISM%SMPDB%SMP0000007 beta-Alanine Metabolism UPB1 CNDP1 AOC3 ALDH6A1 ALDH2 DPYS GAD1 DPYD ABAT BETAINE METABOLISM%SMPDB%SMP0000123 Betaine Metabolism BHMT AHCY MAT2A CHDH PEMT MTR MAT2B ALDH7A1 BIOTIN METABOLISM%SMPDB%SMP0000066 Biotin Metabolism BTD SPCS1 HLCS ACACB BUTYRATE METABOLISM%PATHWHIZ%PW000014 Butyrate Metabolism HMGCL ECHS1 OXCT1 ACSM1 HADH ACADS ACAT1 CAFFEINE METABOLISM%SMPDB%SMP0000028 Caffeine Metabolism CYP2C9 CYP2C8 CYP2A6 NAT2 CYP1A2 CYP2E1 CYP3A4 XDH CARNITINE SYNTHESIS%SMPDB%SMP0000465 Carnitine Synthesis TMLHE SHMT1 SETD7 BBOX1 ALDH9A1 CATECHOLAMINE BIOSYNTHESIS%SMPDB%SMP0000012 Catecholamine Biosynthesis PNMT DDC TH CYSTEINE METABOLISM%PATHWHIZ%PW000018 Cysteine Metabolism CARS1 CDO1 MPST LDHA GCLC GOT1 CTH CTNS GCLM D-ARGININE AND D-ORNITHINE METABOLISM%PATHWHIZ%PW000019 D-Arginine and D-Ornithine Metabolism DAO DEGRADATION OF SUPEROXIDES%PATHWHIZ%PW000020 Degradation of Superoxides CAT TYRP1 SOD2 SOD3 SOD1 ETHANOL DEGRADATION%PATHWHIZ%PW000021 Ethanol Degradation ACSS2 ALDH2 ALDH1B1 ADH1B CAT CYP2E1 ACSS1 FATTY ACID ELONGATION IN MITOCHONDRIA%SMPDB%SMP0000054 Fatty Acid Elongation in Mitochondria HADHB HADHA ECHS1 ACAA2 MECR PPT1 HSD17B10 FATTY ACID METABOLISM%PATHWHIZ%PW000023 Fatty Acid Metabolism GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS FOLATE METABOLISM%SMPDB%SMP0000053 Folate Metabolism MTHFD1 MTHFD1L MTHFD2 FPGS MTHFR GGH MTHFS FTCD DHFR ALDH1L1 MTFMT SLC46A1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0000064 Fructose and Mannose Degradation ALDOA GFUS PHPT1 FBP1 PFKFB1 TPI1 PMM1 MPI SORD AKR1B1 HK1 KHK GMPPB PFKL GMDS FCSK FPGT ALDOB GLYCEROL PHOSPHATE SHUTTLE%SMPDB%SMP0000124 Glycerol Phosphate Shuttle GPD2 GPD1 GAPDH HOMOCYSTEINE DEGRADATION%SMPDB%SMP0000455 Homocysteine Degradation CBS CTH KETONE BODY METABOLISM%PATHWHIZ%PW000028 Ketone Body Metabolism HMGCL BDH1 OXCT1 ACAT1 LYSINE DEGRADATION%PATHWHIZ%PW000029 Lysine Degradation GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS MALATE-ASPARTATE SHUTTLE%PATHWHIZ%PW000030 Malate-Aspartate Shuttle MDH2 GOT2 SLC25A12 SLC25A11 NUCLEOTIDE SUGARS METABOLISM%PATHWHIZ%PW000031 Nucleotide Sugars Metabolism UGDH GALE GALT UGP2 UXS1 GCK PGM1 GALK1 PANTOTHENATE AND COA BIOSYNTHESIS%SMPDB%SMP0000027 Pantothenate and CoA Biosynthesis VNN1 PANK1 PPCS ENPP1 COASY PPCDC PHENYLACETATE METABOLISM%SMPDB%SMP0000126 Phenylacetate Metabolism ACSM1 GLYAT ACSM2B PYRUVALDEHYDE DEGRADATION%SMPDB%SMP0000459 Pyruvaldehyde Degradation GLO1 LDHD HAGH RIBOFLAVIN METABOLISM%SMPDB%SMP0000070 Riboflavin Metabolism FLAD1 RFK ENPP1 TYR ACP1 THIAMINE METABOLISM%SMPDB%SMP0000076 Thiamine Metabolism THTPA TPK1 NTPCR SLC19A2 SPERMIDINE AND SPERMINE BIOSYNTHESIS%PATHWHIZ%PW000037 Spermidine and Spermine Biosynthesis MAT2A ODC1 AMD1 SMS MAT2B SRM TAURINE AND HYPOTAURINE METABOLISM%SMPDB%SMP0000021 Taurine and Hypotaurine Metabolism GGT6 GAD1 CDO1 ADO CSAD UBIQUINONE BIOSYNTHESIS%SMPDB%SMP0000065 Ubiquinone Biosynthesis COQ3 COQ2 COQ7 COQ6 COQ5 SULFATE SULFITE METABOLISM%PATHWHIZ%PW000040 Sulfate Sulfite Metabolism SULT2B1 SULT1A1 CHST11 BPNT1 SUOX PAPSS2 PHYTANIC ACID PEROXISOMAL OXIDATION%PATHWHIZ%PW000041 Phytanic Acid Peroxisomal Oxidation ALDH3A2 PHYH ABCD2 HACL1 SLC27A2 ABCD1 PHENYLALANINE AND TYROSINE METABOLISM%PATHWHIZ%PW000042 Phenylalanine and Tyrosine Metabolism TAT FAH YARS1 FARSA HPD FARSB GSTZ1 IL4I1 GOT1 HGD PAH HISTIDINE METABOLISM%SMPDB%SMP0000044 Histidine Metabolism AMDHD1 CARNS1 HARS1 AOC1 CARNMT1 MAOA HDC PRMT3 HNMT HARS2 FTCD CNDP1 CNDP2 ALDH3A1 HAL ALDH2 UROC1 ARACHIDONIC ACID METABOLISM%SMPDB%SMP0000075 Arachidonic Acid Metabolism ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ANDROGEN AND ESTROGEN METABOLISM%SMPDB%SMP0000068 Androgen and Estrogen Metabolism SRD5A1 HSD17B1 HSD3B1 AKR1D1 HSD17B3 UGT2B17 CYP19A1 CYP17A1 SULT2B1 UGT2B11 STS SULT1E1 GLUCOSE-ALANINE CYCLE%SMPDB%SMP0000127 Glucose-Alanine Cycle GLUD1 GPT2 SLC2A2 GPT SLC1A4 SLC2A4 SLC25A22 SLC38A4 VITAMIN K METABOLISM%SMPDB%SMP0000464 Vitamin K Metabolism VKORC1 NQO1 GGCX PHOSPHOLIPID BIOSYNTHESIS%SMPDB%SMP0000025 Phospholipid Biosynthesis CDS1 DGKA CHAT GDE1 AGPAT1 PLD2 PGS1 PTDSS2 PTDSS1 PTPMT1 CDIPT LYPLA1 PLA2G2D PCYT1A CHKA PLA2G4B CRLS1 PISD PLA2G15 PHOSPHO1 GPAM GPD2 GPD1 PEMT PLPP1 LACTOSE SYNTHESIS%SMPDB%SMP0000444 Lactose Synthesis NME2 CMPK1 LALBA G6PC1 SLC35A2 GALT B4GALT1 UGP2 CANT1 SLC2A1 STEROID BIOSYNTHESIS%PATHWHIZ%PW000050 Steroid Biosynthesis ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS VALINE, LEUCINE, AND ISOLEUCINE DEGRADATION%PATHWHIZ%PW000051 Valine, Leucine, and Isoleucine Degradation ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD PURINE METABOLISM%PATHWHIZ%PW000052 Purine Metabolism PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 VITAMIN B6 METABOLISM%PATHWHIZ%PW000053 Vitamin B6 Metabolism PDXK PNPO ALPL AOX1 PDXP PYRUVATE METABOLISM%PATHWHIZ%PW000054 Pyruvate Metabolism GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0000031 Pentose Phosphate Pathway GPI G6PD RPE TALDO1 PGD DERA RPIA PFKL PGLS ALDOA PRPS1L1 TKT FBP1 PGM1 RBKS METHIONINE METABOLISM%SMPDB%SMP0000033 Methionine Metabolism DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 PRIMARY HYPEROXALURIA TYPE I%SMPDB%SMP0000352 Primary Hyperoxaluria Type I PC AARS2 MPC1 GPT AGXT PYRUVATE CARBOXYLASE DEFICIENCY%SMPDB%SMP0000350 Pyruvate Carboxylase Deficiency PC AARS2 MPC1 GPT AGXT 17-BETA HYDROXYSTEROID DEHYDROGENASE III DEFICIENCY%SMPDB%SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency SRD5A1 HSD17B1 HSD3B1 AKR1D1 HSD17B3 UGT2B17 CYP19A1 CYP17A1 SULT2B1 UGT2B11 STS SULT1E1 BETA-KETOTHIOLASE DEFICIENCY%SMPDB%SMP0000173 beta-Ketothiolase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000061 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD PROPIONIC ACIDEMIA%PATHWHIZ%PW000062 Propionic Acidemia ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE DEFICIENCY%PATHWHIZ%PW000063 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD MAPLE SYRUP URINE DISEASE%PATHWHIZ%PW000064 Maple Syrup Urine Disease ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY TYPE I%SMPDB%SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-METHYLGLUTACONIC ACIDURIA TYPE I%SMPDB%SMP0000139 3-Methylglutaconic Aciduria Type I ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-METHYLGLUTACONIC ACIDURIA TYPE III%SMPDB%SMP0000140 3-Methylglutaconic Aciduria Type III ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD METHYLMALONIC ACIDURIA%SMPDB%SMP0000200 Methylmalonic Aciduria ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 4-HYDROXYBUTYRIC ACIDURIA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000243 4-Hydroxybutyric Aciduria Succinic Semialdehyde Dehydrogenase Deficiency ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT HOMOCARNOSINOSIS%SMPDB%SMP0000385 Homocarnosinosis ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT HYPERINSULINISM-HYPERAMMONEMIA SYNDROME%PATHWHIZ%PW000072 Hyperinsulinism-Hyperammonemia Syndrome ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT GLUTATHIONE SYNTHETASE DEFICIENCY%PATHWHIZ%PW000073 Glutathione Synthetase Deficiency GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 5-OXOPROLINURIA%PATHWHIZ%PW000074 5-Oxoprolinuria GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 ADENOSINE DEAMINASE DEFICIENCY%PATHWHIZ%PW000075 Adenosine Deaminase Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 ADENYLOSUCCINATE LYASE DEFICIENCY%SMPDB%SMP0000167 Adenylosuccinate Lyase Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 GOUT OR KELLEY-SEEGMILLER SYNDROME%SMPDB%SMP0000365 Gout or Kelley-Seegmiller Syndrome PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 LESCH-NYHAN SYNDROME (LNS)%SMPDB%SMP0000364 Lesch-Nyhan Syndrome (LNS) PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 MOLYBDENUM COFACTOR DEFICIENCY%SMPDB%SMP0000203 Molybdenum Cofactor Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 XANTHINE DEHYDROGENASE DEFICIENCY (XANTHINURIA)%SMPDB%SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria) PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY%SMPDB%SMP0000210 Purine Nucleoside Phosphorylase Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 AICA-RIBOSIDURIA%PATHWHIZ%PW000082 AICA-Ribosiduria PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 PROLIDASE DEFICIENCY (PD)%PATHWHIZ%PW000083 Prolidase Deficiency (PD) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO ARGININE: GLYCINE AMIDINOTRANSFERASE DEFICIENCY (AGAT DEFICIENCY)%PATHWHIZ%PW000084 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO HYPERPROLINEMIA TYPE II%SMPDB%SMP0000360 Hyperprolinemia Type II EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO HYPERPROLINEMIA TYPE I%SMPDB%SMP0000361 Hyperprolinemia Type I EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO PROLINEMIA TYPE II%PATHWHIZ%PW000087 Prolinemia Type II EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY (GAMT DEFICIENCY)%SMPDB%SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO ORNITHINE AMINOTRANSFERASE DEFICIENCY (OAT DEFICIENCY)%SMPDB%SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO AROMATIC L-AMINOACID DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000090 Aromatic L-Aminoacid Decarboxylase Deficiency PNMT DDC TH ISOVALERIC ACIDURIA%PATHWHIZ%PW000091 Isovaleric Aciduria ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD BIOTINIDASE DEFICIENCY%SMPDB%SMP0000174 Biotinidase Deficiency BTD SPCS1 HLCS ACACB CANAVAN DISEASE%SMPDB%SMP0000175 Canavan Disease ADSL GAD1 CAD ASNS ABAT ASS1 DARS1 ASRGL1 DDO IL4I1 NARS1 ASL ADSS1 ASPA HYPOACETYLASPARTIA%PATHWHIZ%PW000094 Hypoacetylaspartia ADSL GAD1 CAD ASNS ABAT ASS1 DARS1 ASRGL1 DDO IL4I1 NARS1 ASL ADSS1 ASPA SMITH-LEMLI-OPITZ SYNDROME (SLOS)%PATHWHIZ%PW000095 Smith-Lemli-Opitz Syndrome (SLOS) ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CHILD SYNDROME%PATHWHIZ%PW000096 CHILD Syndrome ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS DESMOSTEROLOSIS%PATHWHIZ%PW000097 Desmosterolosis ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CHONDRODYSPLASIA PUNCTATA II, X-LINKED DOMINANT (CDPX2)%SMPDB%SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS LYSOSOMAL ACID LIPASE DEFICIENCY (WOLMAN DISEASE)%PATHWHIZ%PW000099 Lysosomal Acid Lipase Deficiency (Wolman Disease) ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%SMPDB%SMP0000177 Cystathionine beta-Synthase Deficiency DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 HYPERMETHIONINEMIA%SMPDB%SMP0000341 Hypermethioninemia DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 S-ADENOSYLHOMOCYSTEINE (SAH) HYDROLASE DEFICIENCY%PATHWHIZ%PW000102 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 GLYCINE N-METHYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000222 Glycine N-Methyltransferase Deficiency DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%SMPDB%SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 METHIONINE ADENOSYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000221 Methionine Adenosyltransferase Deficiency DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 ETHYLMALONIC ENCEPHALOPATHY%PATHWHIZ%PW000106 Ethylmalonic Encephalopathy GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000185 Glutaric Aciduria Type I GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS SHORT-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD DEFICIENCY)%PATHWHIZ%PW000108 Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS GABA-TRANSAMINASE DEFICIENCY%SMPDB%SMP0000351 GABA-Transaminase Deficiency UPB1 CNDP1 AOC3 ALDH6A1 ALDH2 DPYS GAD1 DPYD ABAT GAMMA-GLUTAMYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000110 gamma-Glutamyltransferase Deficiency GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000186 Glutaric Aciduria Type I GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS SACCHAROPINURIA HYPERLYSINEMIA II%SMPDB%SMP0000239 Saccharopinuria Hyperlysinemia II GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS HISTIDINEMIA%PATHWHIZ%PW000113 Histidinemia AMDHD1 CARNS1 HARS1 AOC1 CARNMT1 MAOA HDC PRMT3 HNMT HARS2 FTCD CNDP1 CNDP2 ALDH3A1 HAL ALDH2 UROC1 LACTIC ACIDEMIA%PATHWHIZ%PW000114 Lactic Acidemia PC AARS2 MPC1 GPT AGXT LEIGH SYNDROME%SMPDB%SMP0000196 Leigh Syndrome GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PYRUVATE DECARBOXYLASE E1 COMPONENT DEFICIENCY (PDHE1 DEFICIENCY)%SMPDB%SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000117 Pyruvate Dehydrogenase Complex Deficiency GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 LEUKOTRIENE C4 SYNTHESIS DEFICIENCY%PATHWHIZ%PW000118 Leukotriene C4 Synthesis Deficiency ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES PHENYLKETONURIA%PATHWHIZ%PW000119 Phenylketonuria TAT FAH YARS1 FARSA HPD FARSB GSTZ1 IL4I1 GOT1 HGD PAH TYROSINEMIA TYPE 2 (OR RICHNER-HANHART SYNDROME)%SMPDB%SMP0000369 Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) TAT FAH YARS1 FARSA HPD FARSB GSTZ1 IL4I1 GOT1 HGD PAH TYROSINEMIA TYPE 3 (TYRO3)%PATHWHIZ%PW000121 Tyrosinemia Type 3 (TYRO3) TAT FAH YARS1 FARSA HPD FARSB GSTZ1 IL4I1 GOT1 HGD PAH REFSUM DISEASE%SMPDB%SMP0000451 Refsum Disease ALDH3A2 PHYH ABCD2 HACL1 SLC27A2 ABCD1 SIALURIA OR FRENCH TYPE SIALURIA%SMPDB%SMP0000216 Sialuria or French Type Sialuria NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 SALLA DISEASE INFANTILE SIALIC ACID STORAGE DISEASE%SMPDB%SMP0000240 Salla Disease Infantile Sialic Acid Storage Disease NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 PIROXICAM ACTION PATHWAY%SMPDB%SMP0000077 Piroxicam Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES IBANDRONATE ACTION PATHWAY%SMPDB%SMP0000079 Ibandronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS SIMVASTATIN ACTION PATHWAY%PATHWHIZ%PW000127 Simvastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACETYLSALICYLIC ACID ACTION PATHWAY%PATHWHIZ%PW000128 Acetylsalicylic Acid Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ETODOLAC ACTION PATHWAY%PATHWHIZ%PW000129 Etodolac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES KETOPROFEN ACTION PATHWAY%SMPDB%SMP0000085 Ketoprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES IBUPROFEN ACTION PATHWAY%SMPDB%SMP0000086 Ibuprofen Action Pathway UGT1A10 GGT1 PTGDS CBR1 PDIA2 GPX1 PTGIS UGT1A1 PLA2G4B CYP4A11 PDIA6 PDIA4 CYP2U1 DNAJB11 ERP29 UGT2B4 CYP2E1 PPIB UGT2B7 PTGES SLC22A6 ALOX15 ALOX12B ALOX12 CYP3A4 CYP2C19 PTGS2 LTC4S PTGS1 HSP90B1 CYP2B6 ALOX5 UGT1A3 LTA4H UGT1A9 CYP2J2 SDF2L1 HSPA5 EPHX2 CYP4F2 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C9 CYP2C8 PRXL2B TBXAS1 HYOU1 SLC22A8 ROFECOXIB ACTION PATHWAY%SMPDB%SMP0000087 Rofecoxib Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES PRAVASTATIN ACTION PATHWAY%SMPDB%SMP0000089 Pravastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ROSUVASTATIN ACTION PATHWAY%SMPDB%SMP0000092 Rosuvastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS DICLOFENAC ACTION PATHWAY%PATHWHIZ%PW000135 Diclofenac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES SULINDAC ACTION PATHWAY%PATHWHIZ%PW000136 Sulindac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ALENDRONATE ACTION PATHWAY%PATHWHIZ%PW000137 Alendronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CELECOXIB ACTION PATHWAY%SMPDB%SMP0000096 Celecoxib Action Pathway CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES UGT1A10 ADH1B ADH1A ALOX15 ALOX12B ALOX12 CYP3A4 PTGS2 LTC4S PTGS1 CYP2B6 CYP2D6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C9 KETOROLAC ACTION PATHWAY%SMPDB%SMP0000098 Ketorolac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES PTERINE BIOSYNTHESIS%PATHWHIZ%PW000140 Pterine Biosynthesis DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS STEROIDOGENESIS%SMPDB%SMP0000130 Steroidogenesis CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 TYROSINE METABOLISM%SMPDB%SMP0000006 Tyrosine Metabolism PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT INOSITOL METABOLISM%SMPDB%SMP0000011 Inositol Metabolism FIG4 INPP4A MINPP1 PIKFYVE IMPA1 PIK3CA PTPMT1 ITPKA PI4KA INPP5J PIK3C3 PLCD3 IPPK VAC14 BECN1 MIOX ISYNA1 INPP1 ITPK1 IPMK PIK3R4 AMBRA1 GLYCEROLIPID METABOLISM%SMPDB%SMP0000039 Glycerolipid Metabolism GPD1 LPL AKR1B1 AGPAT1 PLPP2 PLPP1 ALDH3A1 LIPC GPAM GPD2 GLYCTK BILE ACID BIOSYNTHESIS%SMPDB%SMP0000035 Bile Acid Biosynthesis ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 GLYCOLYSIS%PATHWHIZ%PW000146 Glycolysis GPI PKLR PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK2 PGK1 GALM ALDOA GAPDH PFKM SPHINGOLIPID METABOLISM%SMPDB%SMP0000034 Sphingolipid Metabolism UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG PROPANOATE METABOLISM%SMPDB%SMP0000016 Propanoate Metabolism ACSS1 DLD HIBCH LDHAL6B BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT MLYCD ACADM STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW000150 Starch and Sucrose Metabolism GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 NICOTINATE AND NICOTINAMIDE METABOLISM%PATHWHIZ%PW000151 Nicotinate and Nicotinamide Metabolism NNMT QPRT NMNAT2 NT5C2 NADSYN1 BST1 PNP NNT NMRK1 NAMPT ENPP1 AOX1 NADK NUDT12 GLUCONEOGENESIS%PATHWHIZ%PW000152 Gluconeogenesis HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 LACTOSE DEGRADATION%SMPDB%SMP0000457 Lactose Degradation ATP1A3 ATP1A2 ATP1B3 ATP1A1 SLC5A1 ATP1B2 ATP1B1 LCT FXYD2 ATP1A4 ATP1B4 SLC2A2 TRANSFER OF ACETYL GROUPS INTO MITOCHONDRIA%SMPDB%SMP0000466 Transfer of Acetyl Groups into Mitochondria SLC25A11 ACLY PDHA1 PC MDH1 MPC1 ME1 PDHB OXIDATION OF BRANCHED-CHAIN FATTY ACIDS%SMPDB%SMP0000030 Oxidation of Branched-Chain Fatty Acids HACL1 SLC25A20 ABCD1 CRAT PEX13 PEX14 PHYH ABCD2 ALDH2 CPT2 ACSL1 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000462 Inositol Phosphate Metabolism IPPK ISYNA1 INPP1 ITPK1 IPMK NUDT3 INPP4A INPP4B MINPP1 IMPA1 PPIP5K1 ITPKA INPP5J IP6K1 GLYCINE AND SERINE METABOLISM%SMPDB%SMP0000004 Glycine and Serine Metabolism GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 PORPHYRIN METABOLISM%SMPDB%SMP0000024 Porphyrin Metabolism UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 GALACTOSE METABOLISM%SMPDB%SMP0000043 Galactose Metabolism GLB1 GAA AKR1B1 LCT GLA G6PC1 PGM1 HK1 GALE GALT B4GALT1 UGP2 PYRIMIDINE METABOLISM%PATHWHIZ%PW000160 Pyrimidine Metabolism TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS%PATHWHIZ%PW000161 Beta Oxidation of Very Long Chain Fatty Acids ABCD1 CRAT PEX13 PEX14 ABCD2 CPT2 ACSL1 SLC25A20 CROT PEX11G UREA CYCLE%PATHWHIZ%PW000162 Urea Cycle ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC TRYPTOPHAN METABOLISM%SMPDB%SMP0000063 Tryptophan Metabolism CAT AFMID CYP1A1 IDO1 TPH1 DDC AADAT HAAO ASMT KMO INMT WARS1 ACMSD WARS2 AANAT ALDH2 TDO2 KYNU RETINOL METABOLISM%SMPDB%SMP0000074 Retinol Metabolism CYP2A7 CYP2A6 DHRS9 ALDH1A2 ALDH1A1 DNAJB11 ERP29 PNPLA4 HYOU1 PPIB RETSAT RDH8 ADH1A CYP3A4 CYP3A5 CYP3A7 HSP90B1 CYP2B6 CYP2A13 AWAT1 RDH12 RDH11 RDH16 LRAT BCO1 PDIA2 SDF2L1 DGAT1 HSPA5 UGT1A1 CYP3A43 PDIA6 DHRS3 RPE65 PDIA4 DHRS4 CYP26A1 MITOCHONDRIAL ELECTRON TRANSPORT CHAIN%SMPDB%SMP0000355 Mitochondrial Electron Transport Chain ATP5F1A ATP5F1B GPD2 UQCRC1 CYCS SLC37A4 GAPDH SLC25A4 MT-CO1 ATP5PB NDUFA1 ATP5MC2 SDHC SDHD SDHA ATP5F1C SDHB ATP5F1D ATP5F1E MT-ATP6 THREONINE AND 2-OXOBUTANOATE DEGRADATION%SMPDB%SMP0000452 Threonine and 2-Oxobutanoate Degradation BCKDHA SDS PCCA PCCB DBT BCKDHB MMUT DLD FATTY ACID BIOSYNTHESIS%SMPDB%SMP0000456 Fatty Acid Biosynthesis FASN ACACA PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463 Phosphatidylinositol Phosphate Metabolism INPP4B PIKFYVE SYNJ1 INPP5D ERBB2 INPP5E PI4KA PIP4K2A PIP5K1A PIK3C3 CDIPT PLCB1 VAC14 BECN1 PTEN PIK3R4 PIK3CD PIK3R1 AMBRA1 PIK3C2A EGFR FIG4 TREHALOSE DEGRADATION%PATHWHIZ%PW000169 Trehalose Degradation TREH ATP1A4 ATP1B4 SLC2A2 ATP1A3 ATP1A2 ATP1B3 ATP1A1 SLC5A1 ATP1B2 ATP1B1 GCK FXYD2 PLASMALOGEN SYNTHESIS%PATHWHIZ%PW000170 Plasmalogen Synthesis GNPAT AGPS CEPT1 AGPAT1 PLPP1 MITOCHONDRIAL BETA-OXIDATION OF SHORT CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000171 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids ACSS3 ECHS1 ACAA2 ACADL HADH ACADS HSD17B10 ACAT1 MITOCHONDRIAL BETA-OXIDATION OF MEDIUM CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000172 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids HADHB HADHA ECHS1 ACAA2 ACSM1 SLC25A20 ACADM HADH MITOCHONDRIAL BETA-OXIDATION OF LONG CHAIN SATURATED FATTY ACIDS%SMPDB%SMP0000482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids ACADL ACSL1 SLC25A20 HADH HADHB HADHA CPT1A ECHS1 ACAA2 CPT2 ACUTE INTERMITTENT PORPHYRIA%PATHWHIZ%PW000174 Acute Intermittent Porphyria UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 PORPHYRIA VARIEGATA (PV)%SMPDB%SMP0000346 Porphyria Variegata (PV) UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP) OR GUNTHER DISEASE%SMPDB%SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 ADRENAL HYPERPLASIA TYPE 3 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 CONGENITAL LIPOID ADRENAL HYPERPLASIA (CLAH) OR LIPOID CAH%SMPDB%SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 ADRENAL HYPERPLASIA TYPE 5 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 17 ALPHA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 ALKAPTONURIA%PATHWHIZ%PW000180 Alkaptonuria PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT HAWKINSINURIA%PATHWHIZ%PW000181 Hawkinsinuria PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT TYROSINEMIA TYPE I%PATHWHIZ%PW000182 Tyrosinemia Type I PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT ARGININEMIA%PATHWHIZ%PW000183 Argininemia ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC ARGININOSUCCINIC ACIDURIA%PATHWHIZ%PW000184 Argininosuccinic Aciduria ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC CITRULLINEMIA TYPE I%PATHWHIZ%PW000185 Citrullinemia Type I ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC DEFICIENCY)%SMPDB%SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC BETA-UREIDOPROPIONASE DEFICIENCY%PATHWHIZ%PW000187 beta-Ureidopropionase Deficiency TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 UMP SYNTHASE DEFICIENCY (OROTIC ACIDURIA)%SMPDB%SMP0000219 UMP Synthase Deficiency (Orotic Aciduria) TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 DIHYDROPYRIMIDINASE DEFICIENCY%SMPDB%SMP0000178 Dihydropyrimidinase Deficiency TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 MNGIE (MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY)%PATHWHIZ%PW000190 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY%SMPDB%SMP0000002 Carbamoyl Phosphate Synthetase Deficiency ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE II%PATHWHIZ%PW000192 Congenital Bile Acid Synthesis Defect Type II ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE III%PATHWHIZ%PW000193 Congenital Bile Acid Synthesis Defect Type III ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 FAMILIAL HYPERCHOLANEMIA (FHCA)%PATHWHIZ%PW000194 Familial Hypercholanemia (FHCA) ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 ZELLWEGER SYNDROME%PATHWHIZ%PW000195 Zellweger Syndrome ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 CEREBROTENDINOUS XANTHOMATOSIS (CTX)%PATHWHIZ%PW000196 Cerebrotendinous Xanthomatosis (CTX) ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000242 Dimethylglycine Dehydrogenase Deficiency GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DHPD)%SMPDB%SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 SARCOSINEMIA%SMPDB%SMP0000244 Sarcosinemia GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 GALACTOSEMIA%PATHWHIZ%PW000200 Galactosemia GLB1 GAA AKR1B1 LCT GLA G6PC1 PGM1 HK1 GALE GALT B4GALT1 UGP2 GAUCHER DISEASE%PATHWHIZ%PW000201 Gaucher Disease UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG GLOBOID CELL LEUKODYSTROPHY%PATHWHIZ%PW000202 Globoid Cell Leukodystrophy UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG METACHROMATIC LEUKODYSTROPHY (MLD)%SMPDB%SMP0000347 Metachromatic Leukodystrophy (MLD) UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG GLYCEROL KINASE DEFICIENCY%SMPDB%SMP0000187 Glycerol Kinase Deficiency GPD1 LPL AKR1B1 AGPAT1 PLPP2 PLPP1 ALDH3A1 LIPC GPAM GPD2 GLYCTK GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0000374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 LACTOSE INTOLERANCE%PATHWHIZ%PW000206 Lactose Intolerance ATP1A3 ATP1A2 ATP1B3 ATP1A1 SLC5A1 ATP1B2 ATP1B1 LCT FXYD2 ATP1A4 ATP1B4 SLC2A2 MALONIC ACIDURIA%SMPDB%SMP0000198 Malonic Aciduria ACSS1 DLD HIBCH LDHAL6B BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT MLYCD ACADM METHYLMALONIC ACIDURIA DUE TO COBALAMIN-RELATED DISORDERS%PATHWHIZ%PW000208 Methylmalonic Aciduria Due to Cobalamin-Related Disorders ACSS1 DLD HIBCH LDHAL6B BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT MLYCD ACADM NON-KETOTIC HYPERGLYCINEMIA%PATHWHIZ%PW000209 Non-Ketotic Hyperglycinemia GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 VITAMIN A DEFICIENCY%SMPDB%SMP0000336 Vitamin A Deficiency CYP2A7 CYP2A6 DHRS9 ALDH1A2 ALDH1A1 DNAJB11 ERP29 PNPLA4 HYOU1 PPIB RETSAT RDH8 ADH1A CYP3A4 CYP3A5 CYP3A7 HSP90B1 CYP2B6 CYP2A13 AWAT1 RDH12 RDH11 RDH16 LRAT BCO1 PDIA2 SDF2L1 DGAT1 HSPA5 UGT1A1 CYP3A43 PDIA6 DHRS3 RPE65 PDIA4 DHRS4 CYP26A1 HEREDITARY COPROPORPHYRIA (HCP)%SMPDB%SMP0000342 Hereditary Coproporphyria (HCP) UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 2-HYDROXYGLUTRIC ACIDURIA (D AND L FORM)%SMPDB%SMP0000136 2-Hydroxyglutric Aciduria (D and L Form) ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT 3-METHYLGLUTACONIC ACIDURIA TYPE IV%SMPDB%SMP0000141 3-Methylglutaconic Aciduria Type IV ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD TAY-SACHS DISEASE%PATHWHIZ%PW000215 Tay-Sachs Disease NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 GLUCOSE TRANSPORTER DEFECT (SGLT2)%SMPDB%SMP0000184 Glucose Transporter Defect (SGLT2) SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A HARTNUP DISORDER%SMPDB%SMP0000189 Hartnup Disorder SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A IMINOGLYCINURIA%PATHWHIZ%PW000219 Iminoglycinuria SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A LYSINURIC PROTEIN INTOLERANCE%SMPDB%SMP0000197 Lysinuric Protein Intolerance SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A HYPERCHOLESTEROLEMIA%PATHWHIZ%PW000221 Hypercholesterolemia ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS NEURON FUNCTION%SMPDB%SMP0000224 Neuron Function PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 BENAZEPRIL ACTION PATHWAY%SMPDB%SMP0000145 Benazepril Action Pathway ACE REN AGT CAPTOPRIL ACTION PATHWAY%SMPDB%SMP0000146 Captopril Action Pathway ACE REN AGT CILAZAPRIL ACTION PATHWAY%SMPDB%SMP0000147 Cilazapril Action Pathway ACE REN AGT ENALAPRIL ACTION PATHWAY%SMPDB%SMP0000148 Enalapril Action Pathway ACE REN AGT FOSINOPRIL ACTION PATHWAY%PATHWHIZ%PW000227 Fosinopril Action Pathway ACE REN AGT LISINOPRIL ACTION PATHWAY%PATHWHIZ%PW000228 Lisinopril Action Pathway ACE REN AGT MOEXIPRIL ACTION PATHWAY%SMPDB%SMP0000151 Moexipril Action Pathway ACE REN AGT PERINDOPRIL ACTION PATHWAY%SMPDB%SMP0000152 Perindopril Action Pathway ACE REN AGT QUINAPRIL ACTION PATHWAY%SMPDB%SMP0000153 Quinapril Action Pathway ACE REN AGT RAMIPRIL ACTION PATHWAY%SMPDB%SMP0000154 Ramipril Action Pathway ACE REN AGT RESCINNAMINE ACTION PATHWAY%SMPDB%SMP0000155 Rescinnamine Action Pathway ACE REN AGT SPIRAPRIL ACTION PATHWAY%SMPDB%SMP0000156 Spirapril Action Pathway ACE REN AGT TRANDOLAPRIL ACTION PATHWAY%SMPDB%SMP0000157 Trandolapril Action Pathway ACE REN AGT BEVACIZUMAB ACTION PATHWAY%SMPDB%SMP0000420 Bevacizumab Action Pathway FLT1 KDR VEGFA VATALANIB ACTION PATHWAY%SMPDB%SMP0000421 Vatalanib Action Pathway KDR IRINOTECAN ACTION PATHWAY%PATHWHIZ%PW000238 Irinotecan Action Pathway UGT1A1 CYP3A4 CYP3A5 PDIA6 PDIA4 HSP90B1 SLCO1B1 DNAJB11 ERP29 HYOU1 TOP1 UGT1A9 PPIB CES2 CES1 ABCG2 BCHE PDIA2 UGT1A10 ABCC1 ABCB1 ABCC2 SDF2L1 HSPA5 PACLITAXEL ACTION PATHWAY%PATHWHIZ%PW000239 Paclitaxel Action Pathway ABCC1 TUBA1B ABCB1 ABCC2 TUBB1 SLCO1B3 ABCG2 DOCETAXEL ACTION PATHWAY%PATHWHIZ%PW000240 Docetaxel Action Pathway ABCC1 TUBA1B ABCB1 ABCC2 TUBB1 SLCO1B3 ABCG2 VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436 Vinblastine Action Pathway ABCB1 ABCC2 TUBB1 CYP3A4 ABCC10 TP53 ABCC3 ABCC1 CDKN1A TUBA1B RALBP1 VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437 Vincristine Action Pathway ABCC2 TUBB1 ABCC10 TP53 ABCC3 ABCC1 CDKN1A TUBA1B RALBP1 ABCB1 VINDESINE ACTION PATHWAY%SMPDB%SMP0000438 Vindesine Action Pathway ABCC2 TUBB1 ABCC10 TP53 ABCC3 ABCC1 CDKN1A TUBA1B RALBP1 ABCB1 VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439 Vinorelbine Action Pathway ABCB1 ABCC2 TUBB1 CYP3A4 ABCC10 TP53 ABCC3 ABCC1 CDKN1A TUBA1B RALBP1 ETOPOSIDE ACTION PATHWAY%SMPDB%SMP0000442 Etoposide Action Pathway PDIA6 PDIA4 PTGS1 HSP90B1 DNAJB11 ERP29 HYOU1 PPIB ABCC3 TOP2A TOP2B PDIA2 ABCB1 SDF2L1 HSPA5 UGT1A1 CYP3A4 PTGS2 MPO CYP3A5 TENIPOSIDE ACTION PATHWAY%SMPDB%SMP0000443 Teniposide Action Pathway TOP2A CYP3A4 MPO CYP3A5 GEMCITABINE ACTION PATHWAY%SMPDB%SMP0000446 Gemcitabine Action Pathway RRM1 RRM2 CTPS1 TYMS DCK NME1 DCTD NT5C RRM2B CMPK1 SLC29A1 SLC28A1 SLC28A3 CYCLOPHOSPHAMIDE ACTION PATHWAY%PATHWHIZ%PW000248 Cyclophosphamide Action Pathway CYP3A4 CYP2C19 CYP2C9 ALDH3A1 CYP2C8 CYP2A6 GSTM1 CYP2B6 ALDH1A1 IFOSFAMIDE ACTION PATHWAY%PATHWHIZ%PW000249 Ifosfamide Action Pathway CYP2C9 ALDH3A1 CYP2C8 CYP2A6 CYP2B6 ALDH1A1 CYP3A4 CYP3A5 TAMOXIFEN ACTION PATHWAY%SMPDB%SMP0000471 Tamoxifen Action Pathway FMO3 CYP3A4 ESR1 CYP3A5 SULT1A1 UGT1A10 CYP2B6 CYP2D6 UGT1A4 FMO1 ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251 Erlotinib Action Pathway ABCB1 EGFR ABCG2 GEFITINIB ACTION PATHWAY%SMPDB%SMP0000473 Gefitinib Action Pathway EGFR CETUXIMAB ACTION PATHWAY%SMPDB%SMP0000474 Cetuximab Action Pathway EGFR PANITUMUMAB ACTION PATHWAY%SMPDB%SMP0000475 Panitumumab Action Pathway EGFR TRASTUZUMAB ACTION PATHWAY%SMPDB%SMP0000476 Trastuzumab Action Pathway EGFR CAPECITABINE ACTION PATHWAY%PATHWHIZ%PW000256 Capecitabine Action Pathway CDA TYMS SLC28A1 TYMP CES1 FLUOROURACIL ACTION PATHWAY%SMPDB%SMP0000470 Fluorouracil Action Pathway TYMS SUPROFEN ACTION PATHWAY%SMPDB%SMP0000101 Suprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES BROMFENAC ACTION PATHWAY%SMPDB%SMP0000102 Bromfenac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES INDOMETHACIN ACTION PATHWAY%PATHWHIZ%PW000260 Indomethacin Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 PLA2G2A CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES MEFENAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000261 Mefenamic Acid Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES OXAPROZIN ACTION PATHWAY%PATHWHIZ%PW000262 Oxaprozin Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES NABUMETONE ACTION PATHWAY%SMPDB%SMP0000114 Nabumetone Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES NAPROXEN ACTION PATHWAY%SMPDB%SMP0000120 Naproxen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES DIFLUNISAL ACTION PATHWAY%SMPDB%SMP0000289 Diflunisal Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES AZATHIOPRINE ACTION PATHWAY%SMPDB%SMP0000427 Azathioprine Action Pathway PPAT AOX1 RAC1 PRPS1L1 XDH ATAD1 ABCC4 GUCY1A2 RRM1 ADSL RRM2 ABCC5 ENTPD5 PDE4D AMPD1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 SLC28A2 SLC29A1 GART ADA ITPA SLC29A2 SLC28A3 GUCY1B1 TPMT GDA AK1 GMPS ADK GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 MERCAPTOPURINE ACTION PATHWAY%PATHWHIZ%PW000267 Mercaptopurine Action Pathway PPAT AOX1 RAC1 PRPS1L1 XDH ATAD1 ABCC4 GUCY1A2 RRM1 ADSL RRM2 ABCC5 ENTPD5 PDE4D AMPD1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 SLC28A2 SLC29A1 GART ADA ITPA SLC29A2 SLC28A3 GUCY1B1 TPMT GDA AK1 GMPS ADK GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 METHOTREXATE ACTION PATHWAY%SMPDB%SMP0000432 Methotrexate Action Pathway MTHFD1 MTHFD1L MTHFD2 FPGS MTHFR GGH MTHFS FTCD DHFR ALDH1L1 MTFMT SLC46A1 LOVASTATIN ACTION PATHWAY%SMPDB%SMP0000099 Lovastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ZOLEDRONATE ACTION PATHWAY%PATHWHIZ%PW000270 Zoledronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CERIVASTATIN ACTION PATHWAY%PATHWHIZ%PW000271 Cerivastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS RISEDRONATE ACTION PATHWAY%PATHWHIZ%PW000272 Risedronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS PAMIDRONATE ACTION PATHWAY%PATHWHIZ%PW000273 Pamidronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS FLUVASTATIN ACTION PATHWAY%PATHWHIZ%PW000274 Fluvastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ATORVASTATIN ACTION PATHWAY%SMPDB%SMP0000131 Atorvastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS MELOXICAM ACTION PATHWAY%SMPDB%SMP0000106 Meloxicam Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES VALDECOXIB ACTION PATHWAY%SMPDB%SMP0000116 Valdecoxib Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES CANDESARTAN ACTION PATHWAY%SMPDB%SMP0000158 Candesartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT EPROSARTAN ACTION PATHWAY%PATHWHIZ%PW000279 Eprosartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT FORASARTAN ACTION PATHWAY%PATHWHIZ%PW000280 Forasartan Action Pathway ACE AGTR1 REN AGT IRBESARTAN ACTION PATHWAY%PATHWHIZ%PW000281 Irbesartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT LOSARTAN ACTION PATHWAY%PATHWHIZ%PW000282 Losartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT OLMESARTAN ACTION PATHWAY%SMPDB%SMP0000163 Olmesartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT TELMISARTAN ACTION PATHWAY%PATHWHIZ%PW000284 Telmisartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT VALSARTAN ACTION PATHWAY%SMPDB%SMP0000165 Valsartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT CLOPIDOGREL ACTION PATHWAY%PATHWHIZ%PW000286 Clopidogrel Action Pathway CYP2C19 CYP3A5 P2RY12 CYP2C9 ABCB1 CYP2B6 CYP1A2 PON1 CYP3A4 TICLOPIDINE ACTION PATHWAY%SMPDB%SMP0000261 Ticlopidine Action Pathway P2RY12 CLOMOCYCLINE ACTION PATHWAY%SMPDB%SMP0000262 Clomocycline Action Pathway rplS CILOSTAZOL ACTION PATHWAY%SMPDB%SMP0000263 Cilostazol Action Pathway PDE4D CYP3A4 CYP2C19 CYP3A5 DIPYRIDAMOLE (ANTIPLATELET) ACTION PATHWAY%SMPDB%SMP0000264 Dipyridamole (Antiplatelet) Action Pathway PDE4D ABCIXIMAB ACTION PATHWAY%SMPDB%SMP0000265 Abciximab Action Pathway ITGB3 ITGA2B EPTIFIBATIDE ACTION PATHWAY%PATHWHIZ%PW000292 Eptifibatide Action Pathway ITGB3 ITGA2B TIROFIBAN ACTION PATHWAY%PATHWHIZ%PW000293 Tirofiban Action Pathway ITGB3 ITGA2B ENOXAPARIN ACTION PATHWAY%SMPDB%SMP0000272 Enoxaparin Action Pathway F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 SERPINC1 F12 FGG F11 F13A1 PLG PLAT FONDAPARINUX ACTION PATHWAY%SMPDB%SMP0000273 Fondaparinux Action Pathway F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 SERPINC1 F12 FGG F11 F13A1 PLG PLAT HEPARIN ACTION PATHWAY%SMPDB%SMP0000274 Heparin Action Pathway F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 SERPINC1 F12 FGG F11 F13A1 PLG PLAT ARDEPARIN ACTION PATHWAY%SMPDB%SMP0000275 Ardeparin Action Pathway F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 SERPINC1 F12 FGG F11 F13A1 PLG PLAT ARGATROBAN ACTION PATHWAY%SMPDB%SMP0000276 Argatroban Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 BIVALIRUDIN ACTION PATHWAY%SMPDB%SMP0000277 Bivalirudin Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 LEPIRUDIN ACTION PATHWAY%SMPDB%SMP0000278 Lepirudin Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 XIMELAGATRAN ACTION PATHWAY%SMPDB%SMP0000279 Ximelagatran Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ALTEPLASE ACTION PATHWAY%PATHWHIZ%PW000302 Alteplase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ANISTREPLASE ACTION PATHWAY%PATHWHIZ%PW000303 Anistreplase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 STREPTOKINASE ACTION PATHWAY%PATHWHIZ%PW000304 Streptokinase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 TENECTEPLASE ACTION PATHWAY%SMPDB%SMP0000283 Tenecteplase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 UROKINASE ACTION PATHWAY%SMPDB%SMP0000284 Urokinase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 RETEPLASE ACTION PATHWAY%SMPDB%SMP0000285 Reteplase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 AMINOCAPROIC ACID ACTION PATHWAY%PATHWHIZ%PW000308 Aminocaproic Acid Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 TRANEXAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000309 Tranexamic Acid Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 APROTININ ACTION PATHWAY%SMPDB%SMP0000288 Aprotinin Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 WARFARIN ACTION PATHWAY%SMPDB%SMP0000268 Warfarin Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ACENOCOUMAROL ACTION PATHWAY%PATHWHIZ%PW000312 Acenocoumarol Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 DICUMAROL ACTION PATHWAY%PATHWHIZ%PW000313 Dicumarol Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 PHENPROCOUMON ACTION PATHWAY%PATHWHIZ%PW000314 Phenprocoumon Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ESOMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000315 Esomeprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 OMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000316 Omeprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 LANSOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000317 Lansoprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 PANTOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000318 Pantoprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 RABEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000319 Rabeprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 RANITIDINE ACTION PATHWAY%SMPDB%SMP0000230 Ranitidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 FAMOTIDINE ACTION PATHWAY%SMPDB%SMP0000231 Famotidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 CIMETIDINE ACTION PATHWAY%SMPDB%SMP0000232 Cimetidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 NIZATIDINE ACTION PATHWAY%SMPDB%SMP0000233 Nizatidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 PIRENZEPINE ACTION PATHWAY%SMPDB%SMP0000246 Pirenzepine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 CHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000078 Chlorothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A POLYTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000326 Polythiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A METHYCLOTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000327 Methyclothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A BUMETANIDE ACTION PATHWAY%SMPDB%SMP0000088 Bumetanide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A BENDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000329 Bendroflumethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A QUINETHAZONE ACTION PATHWAY%SMPDB%SMP0000091 Quinethazone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A ETHACRYNIC ACID ACTION PATHWAY%SMPDB%SMP0000097 Ethacrynic Acid Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A HYDROCHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000100 Hydrochlorothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A CYCLOTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000103 Cyclothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A METOLAZONE ACTION PATHWAY%SMPDB%SMP0000105 Metolazone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A HYDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000335 Hydroflumethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A INDAPAMIDE ACTION PATHWAY%SMPDB%SMP0000110 Indapamide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A FUROSEMIDE ACTION PATHWAY%PATHWHIZ%PW000337 Furosemide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A TORSEMIDE ACTION PATHWAY%PATHWHIZ%PW000338 Torsemide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A TRICHLORMETHIAZIDE ACTION PATHWAY%SMPDB%SMP0000121 Trichlormethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A CHLORTHALIDONE ACTION PATHWAY%SMPDB%SMP0000122 Chlorthalidone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A TRIAMTERENE ACTION PATHWAY%SMPDB%SMP0000132 Triamterene Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A AMILORIDE ACTION PATHWAY%SMPDB%SMP0000133 Amiloride Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A SPIRONOLACTONE ACTION PATHWAY%SMPDB%SMP0000134 Spironolactone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A EPLERENONE ACTION PATHWAY%SMPDB%SMP0000135 Eplerenone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A AZITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000345 Azithromycin Action Pathway rplS CLARITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000248 Clarithromycin Action Pathway rplS CLINDAMYCIN ACTION PATHWAY%PATHWHIZ%PW000347 Clindamycin Action Pathway rplS ERYTHROMYCIN ACTION PATHWAY%SMPDB%SMP0000250 Erythromycin Action Pathway rplS ROXITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000251 Roxithromycin Action Pathway rplS TELITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000350 Telithromycin Action Pathway rplS AMIKACIN ACTION PATHWAY%SMPDB%SMP0000253 Amikacin Action Pathway rplS GENTAMICIN ACTION PATHWAY%SMPDB%SMP0000254 Gentamicin Action Pathway rplS KANAMYCIN ACTION PATHWAY%SMPDB%SMP0000255 Kanamycin Action Pathway rplS NEOMYCIN ACTION PATHWAY%SMPDB%SMP0000256 Neomycin Action Pathway rplS NETILMICIN ACTION PATHWAY%SMPDB%SMP0000257 Netilmicin Action Pathway rplS SPECTINOMYCIN ACTION PATHWAY%PATHWHIZ%PW000356 Spectinomycin Action Pathway rplS STREPTOMYCIN ACTION PATHWAY%SMPDB%SMP0000259 Streptomycin Action Pathway rplS DEMECLOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000358 Demeclocycline Action Pathway rplS DOXYCYCLINE ACTION PATHWAY%PATHWHIZ%PW000359 Doxycycline Action Pathway rplS MINOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000360 Minocycline Action Pathway rplS OXYTETRACYCLINE ACTION PATHWAY%PATHWHIZ%PW000361 Oxytetracycline Action Pathway rplS TETRACYCLINE ACTION PATHWAY%SMPDB%SMP0000294 Tetracycline Action Pathway rplS LYMECYCLINE ACTION PATHWAY%SMPDB%SMP0000295 Lymecycline Action Pathway rplS ACEBUTOLOL ACTION PATHWAY%SMPDB%SMP0000296 Acebutolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ALPRENOLOL ACTION PATHWAY%SMPDB%SMP0000297 Alprenolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ATENOLOL ACTION PATHWAY%SMPDB%SMP0000298 Atenolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BETAXOLOL ACTION PATHWAY%SMPDB%SMP0000299 Betaxolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BISOPROLOL ACTION PATHWAY%SMPDB%SMP0000300 Bisoprolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ESMOLOL ACTION PATHWAY%SMPDB%SMP0000301 Esmolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN METOPROLOL ACTION PATHWAY%PATHWHIZ%PW000370 Metoprolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NADOLOL ACTION PATHWAY%PATHWHIZ%PW000371 Nadolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN OXPRENOLOL ACTION PATHWAY%PATHWHIZ%PW000372 Oxprenolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PENBUTOLOL ACTION PATHWAY%SMPDB%SMP0000305 Penbutolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PINDOLOL ACTION PATHWAY%PATHWHIZ%PW000374 Pindolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PROPRANOLOL ACTION PATHWAY%SMPDB%SMP0000307 Propranolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN QUINIDINE ACTION PATHWAY%SMPDB%SMP0000323 Quinidine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PROCAINAMIDE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000377 Procainamide (Antiarrhythmic) Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN DISOPYRAMIDE ACTION PATHWAY%SMPDB%SMP0000325 Disopyramide Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN FOSPHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000379 Fosphenytoin (Antiarrhythmic) Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000380 Phenytoin (Antiarrhythmic) Action Pathway KCNIP2 EPHX1 CYP2C9 DLG1 FXYD2 CYP1A2 HYOU1 KCNK1 SNTB1 SNTB2 CHRM2 RYR2 ATP2A2 COMT SLC8A1 SCN5A PRKACA SNTA1 KCNH2 PDIA2 UGT1A1 ABCC8 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 PDIA6 PDIA4 CACNB1 PRKAR1A KCNQ1 DNAJB11 ERP29 CYP2E1 PPIB ALG10B HCN4 KCNE1 KCNE2 ATP1A4 ATP1A3 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CYP3A4 CYP2C19 CACNA1H CACNA1G HSP90B1 PLN UGT1A4 UGT1A9 KCNJ2 UGT1A6 KCNJ3 KCNJ4 NQO1 KCNJ5 SDF2L1 HSPA5 KCNJ11 KCNJ8 LIDOCAINE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000381 Lidocaine (Antiarrhythmic) Action Pathway CHRM2 RYR2 ATP2A2 SLC8A1 SCN5A PRKACA SNTA1 KCNH2 ABCC8 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 PRKAR1A KCNQ1 ALG10B HCN4 KCNE1 KCNE2 ATP1A4 ATP1A3 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CYP3A4 CACNA1H CACNA1G PLN KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ11 KCNJ8 KCNIP2 DLG1 FXYD2 CYP1A2 KCNK1 SNTB1 SNTB2 MEXILETINE ACTION PATHWAY%PATHWHIZ%PW000382 Mexiletine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN TOCAINIDE ACTION PATHWAY%SMPDB%SMP0000330 Tocainide Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN FLECAINIDE ACTION PATHWAY%SMPDB%SMP0000331 Flecainide Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN IBUTILIDE ACTION PATHWAY%SMPDB%SMP0000332 Ibutilide Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN DILTIAZEM ACTION PATHWAY%SMPDB%SMP0000359 Diltiazem Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NEBIVOLOL ACTION PATHWAY%SMPDB%SMP0000366 Nebivolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN CARVEDILOL ACTION PATHWAY%SMPDB%SMP0000367 Carvedilol Action Pathway CACNA1G PLN SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C ADRA1A CACNA1H SLC8A1 LABETALOL ACTION PATHWAY%PATHWHIZ%PW000389 Labetalol Action Pathway CACNA1G PLN SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C ADRA1A CACNA1H SLC8A1 VERAPAMIL ACTION PATHWAY%SMPDB%SMP0000375 Verapamil Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN AMLODIPINE ACTION PATHWAY%PATHWHIZ%PW000391 Amlodipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN FELODIPINE ACTION PATHWAY%PATHWHIZ%PW000392 Felodipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ISRADIPINE ACTION PATHWAY%PATHWHIZ%PW000393 Isradipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NIFEDIPINE ACTION PATHWAY%PATHWHIZ%PW000394 Nifedipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NIMODIPINE ACTION PATHWAY%PATHWHIZ%PW000395 Nimodipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NISOLDIPINE ACTION PATHWAY%PATHWHIZ%PW000396 Nisoldipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NITRENDIPINE ACTION PATHWAY%SMPDB%SMP0000382 Nitrendipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BENZOCAINE ACTION PATHWAY%SMPDB%SMP0000392 Benzocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 BUPIVACAINE ACTION PATHWAY%SMPDB%SMP0000393 Bupivacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 CHLOROPROCAINE ACTION PATHWAY%SMPDB%SMP0000394 Chloroprocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 COCAINE ACTION PATHWAY%SMPDB%SMP0000395 Cocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DIBUCAINE ACTION PATHWAY%SMPDB%SMP0000396 Dibucaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LEVOBUPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000403 Levobupivacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LIDOCAINE (LOCAL ANAESTHETIC) ACTION PATHWAY%SMPDB%SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway CYP1A2 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 MEPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000405 Mepivacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 OXYBUPROCAINE ACTION PATHWAY%SMPDB%SMP0000400 Oxybuprocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PRILOCAINE ACTION PATHWAY%PATHWHIZ%PW000407 Prilocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PROCAINE ACTION PATHWAY%PATHWHIZ%PW000408 Procaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PROPARACAINE ACTION PATHWAY%PATHWHIZ%PW000409 Proparacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ROPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000410 Ropivacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 CODEINE ACTION PATHWAY%PATHWHIZ%PW000411 Codeine Action Pathway GRIN3A FXYD2 UGT2B7 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A MORPHINE ACTION PATHWAY%PATHWHIZ%PW000412 Morphine Action Pathway CHRNB2 PDIA2 SDF2L1 HSPA5 UGT1A1 KCND2 KCNIP2 UGT2B15 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 PDIA6 PDIA4 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DNAJB11 ERP29 UGT2B4 HYOU1 PPIB UGT2B7 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 HSP90B1 GRIN2A UGT1A3 DRD1 UGT1A8 SCN1B METHADONE ACTION PATHWAY%PATHWHIZ%PW000414 Methadone Action Pathway OPRM1 ATP1B1 GRIN1 POMC CACNB1 CYP2C8 SCN10A GRIN3A FXYD2 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 CYP2C19 SLC6A2 ADRA1A SLC6A3 CYP3A7 SLC6A4 GRIN2A CYP2B6 CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OXYCODONE ACTION PATHWAY%SMPDB%SMP0000409 Oxycodone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 HYDROMORPHONE ACTION PATHWAY%PATHWHIZ%PW000416 Hydromorphone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 HYDROCODONE ACTION PATHWAY%SMPDB%SMP0000411 Hydrocodone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 OXYMORPHONE ACTION PATHWAY%PATHWHIZ%PW000418 Oxymorphone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ALFENTANIL ACTION PATHWAY%PATHWHIZ%PW000419 Alfentanil Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 CARFENTANIL ACTION PATHWAY%SMPDB%SMP0000414 Carfentanil Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 FENTANYL ACTION PATHWAY%PATHWHIZ%PW000421 Fentanyl Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 REMIFENTANIL ACTION PATHWAY%PATHWHIZ%PW000422 Remifentanil Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 SUFENTANIL ACTION PATHWAY%PATHWHIZ%PW000423 Sufentanil Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 IMIPRAMINE ACTION PATHWAY%SMPDB%SMP0000422 Imipramine Action Pathway CACNB1 SCN10A GRIN3A FXYD2 CYP1A2 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 CYP2C19 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC DESIPRAMINE ACTION PATHWAY%PATHWHIZ%PW000425 Desipramine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 CITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000426 Citalopram Action Pathway ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PCSK2 MAOB MAOA CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP2C19 SLC6A2 ADRA1A SLC6A3 CYP3A7 SLC6A4 GRIN2A CYP2D6 AOX1 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ESCITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000427 Escitalopram Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 FLUOXETINE ACTION PATHWAY%PATHWHIZ%PW000428 Fluoxetine Action Pathway GRIN1 POMC CACNB1 CYP2C9 SCN10A GRIN3A FXYD2 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 CYP2C19 CYP3A5 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 THIOGUANINE ACTION PATHWAY%PATHWHIZ%PW000429 Thioguanine Action Pathway PPAT AOX1 RAC1 PRPS1L1 XDH ATAD1 ABCC4 GUCY1A2 RRM1 ADSL RRM2 ABCC5 ENTPD5 PDE4D AMPD1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 SLC28A2 SLC29A1 GART ADA ITPA SLC29A2 SLC28A3 GUCY1B1 TPMT GDA AK1 GMPS ADK GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 NICOTINE ACTION PATHWAY%SMPDB%SMP0000431 Nicotine Action Pathway ATP1B2 FMO3 OPRM1 ATP1B1 GRIN1 POMC CACNB1 CYP2A6 SCN10A GRIN3A FXYD2 PCSK2 CHRNA3 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2B6 UGT1A4 AOX1 DRD1 UGT1A9 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 DISULFIRAM ACTION PATHWAY%PATHWHIZ%PW000431 Disulfiram Action Pathway HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 ALDH2 ALDH1B1 DCT CAT CYP2E1 ACSS1 PNMT AOC1 DDC ACSS2 GOT1 HGD ADH1B MAOA ADH1A NATEGLINIDE ACTION PATHWAY%SMPDB%SMP0000453 Nateglinide Action Pathway CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 INS REPAGLINIDE ACTION PATHWAY%SMPDB%SMP0000454 Repaglinide Action Pathway CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 INS GLIBENCLAMIDE ACTION PATHWAY%SMPDB%SMP0000460 Glibenclamide Action Pathway CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 INS GLICLAZIDE ACTION PATHWAY%SMPDB%SMP0000461 Gliclazide Action Pathway CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 INS PREDNISONE ACTION PATHWAY%SMPDB%SMP0000440 Prednisone Action Pathway CYP3A4 PREDNISOLONE ACTION PATHWAY%SMPDB%SMP0000441 Prednisolone Action Pathway HSP90AA1 NR3C1 DOPAMINE ACTIVATION OF NEUROLOGICAL REWARD SYSTEM%PATHWHIZ%PW000440 Dopamine Activation of Neurological Reward System GNAS ADCY2 DRD1 PRKACB EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 4 AND SEROTONIN%PATHWHIZ%PW000441 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin GNGT1 CREB1 GNB1 GNAS HTR4 PRKACB ESR1 PPP1CA CORTICOTROPIN ACTIVATION OF CORTISOL PRODUCTION%SMPDB%SMP0000310 Corticotropin Activation of Cortisol Production POMC GNGT1 MC2R GNB1 GNAS PRKACB EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 7 AND SEROTONIN%SMPDB%SMP0000311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin GNGT1 CREB1 HTR7 GNB1 GNAS PRKACB ESR1 PPP1CA EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 6 AND SEROTONIN%SMPDB%SMP0000312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin GNGT1 HTR6 CREB1 GNB1 GNAS PRKACB ESR1 PPP1CA INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2A AND ADENOSINE%SMPDB%SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine NFKBIA MAPK11 CREB1 ADORA2A PIK3CA GNB1 GNAS RAPGEF2 ARHGEF7 RAPGEF3 ATF2 ELK1 PRKCZ IKBKB CDC42 GNGT1 MAPK8 PAK1 RAP1A PARD6A RPS6KA1 MAPK1 AKT1 MAP2K7 HRAS PRKACB MAP3K4 MAP2K6 JUN MAP2K2 MAP3K1 CHUK PDPK1 BAD BRAF NFKB1 NFKB2 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2B AND ADENOSINE%SMPDB%SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine NFKB1 NFKB2 NFKBIA MAPK11 CREB1 PIK3CA ADORA2B GNB1 GNAS RAPGEF2 ARHGEF7 RAPGEF3 ATF2 ADCY2 ELK1 PRKCZ IKBKB CDC42 GNGT1 MAPK8 PAK1 RAP1A PARD6A RPS6KA1 MAPK1 AKT1 MAP2K7 HRAS PRKACB MAP3K4 MAP2K6 JUN MAP2K2 MAP3K1 CHUK PDPK1 BAD BRAF VASOPRESSIN REGULATION OF WATER HOMEOSTASIS%PATHWHIZ%PW000447 Vasopressin Regulation of Water Homeostasis GNGT1 FSHR AVPR2 GNB1 GNAS ADCY2 GNG12 PRKACB INTRACELLULAR SIGNALLING THROUGH FSH RECEPTOR AND FOLLICLE STIMULATING HORMONE%PATHWHIZ%PW000448 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone ADCY2 CGA GNG12 PRKACB ESR1 PPP1CA GNGT1 CREB1 FSHR GNB1 GNAS INTRACELLULAR SIGNALLING THROUGH HISTAMINE H2 RECEPTOR AND HISTAMINE%PATHWHIZ%PW000449 Intracellular Signalling Through Histamine H2 Receptor and Histamine ESR1 PPP1CA GNGT1 CREB1 HRH2 GNB1 GNAS ADCY2 PRKACB INTRACELLULAR SIGNALLING THROUGH LHCGR RECEPTOR AND LUTEINIZING HORMONE CHORIOGONADOTROPIN%SMPDB%SMP0000338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone Choriogonadotropin GNAS ADCY2 CGA PRKACB ESR1 PPP1CA GNGT1 LHCGR CREB1 LHB GNB1 INTRACELLULAR SIGNALLING THROUGH PGD2 RECEPTOR AND PROSTAGLANDIN D2%SMPDB%SMP0000343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 GNGT1 GNB1 GNAS ADCY2 PRKACB PTGDR INTRACELLULAR SIGNALLING THROUGH PROSTACYCLIN RECEPTOR AND PROSTACYCLIN%SMPDB%SMP0000354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin GNGT1 PTGIR MYL3 GNB1 GNAS ADCY2 PRKACB MYLK FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells MAP2K2 SYK IL13 PLA2G4A PRKCA GAB2 MAPK14 IL4 IL3 IL5 PIK3CA BTK IGHE KRAS GRB2 LCP2 RAF1 MS4A2 SOS1 LAT CSF2 PIK3R1 TNF NRAS MAPK8 INPP5D FCER1A MAPK1 AKT1 FYN PLCG1 RAC1 MAP2K7 HRAS MAP2K6 PDK1 LYN MAP2K3 VAV3 MAP2K4 MAP2K1 FCER1G INSULIN SIGNALLING%PATHWHIZ%PW000454 Insulin Signalling MAPK1 AKT1 GRB2 RAF1 SOS1 HRAS MAP2K1 MAP2K2 PDPK1 SHC1 IRS1 INSR IRS2 SLC2A4 PIK3CG FOXO1 PIK3R6 INS MAPK8 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000484 Dimethylglycine Dehydrogenase Deficiency GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 HYPERGLYCINEMIA, NON-KETOTIC%SMPDB%SMP0000485 Hyperglycinemia, Non-Ketotic GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 DOPA-RESPONSIVE DYSTONIA%SMPDB%SMP0000486 DOPA-Responsive Dystonia DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS HYPERPHENYLALANINEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY%SMPDB%SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS HYPERPHENYLALANINEMIA DUE TO 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE DEFICIENCY (PTPS)%SMPDB%SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY%PATHWHIZ%PW000465 Hyperphenylalaninemia Due to DHPR-Deficiency DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS SEGAWA SYNDROME%PATHWHIZ%PW000466 Segawa Syndrome DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS SEPIAPTERIN REDUCTASE DEFICIENCY%PATHWHIZ%PW000467 Sepiapterin Reductase Deficiency DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS CARNOSINURIA, CARNOSINEMIA%SMPDB%SMP0000493 Carnosinuria, Carnosinemia UPB1 CNDP1 AOC3 ALDH6A1 ALDH2 DPYS GAD1 DPYD ABAT TYROSINEMIA, TRANSIENT, OF THE NEWBORN%PATHWHIZ%PW000470 Tyrosinemia, Transient, of the Newborn PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT GALACTOSEMIA II (GALK)%SMPDB%SMP0000495 Galactosemia II (GALK) UGDH GALE GALT UGP2 UXS1 GCK PGM1 GALK1 GALACTOSEMIA III%SMPDB%SMP0000496 Galactosemia III UGDH GALE GALT UGP2 UXS1 GCK PGM1 GALK1 TYROSINE HYDROXYLASE DEFICIENCY%SMPDB%SMP0000497 Tyrosine Hydroxylase Deficiency PNMT DDC TH DOPAMINE BETA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000498 Dopamine beta-Hydroxylase Deficiency PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT BETA-MERCAPTOLACTATE-CYSTEINE DISULFIDURIA%SMPDB%SMP0000499 beta-Mercaptolactate-Cysteine Disulfiduria CARS1 CDO1 MPST LDHA GCLC GOT1 CTH CTNS GCLM 5-OXOPROLINASE DEFICIENCY%PATHWHIZ%PW000476 5-Oxoprolinase Deficiency GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 GAMMA-GLUTAMYLTRANSPEPTIDASE DEFICIENCY%SMPDB%SMP0000501 gamma-Glutamyltranspeptidase Deficiency GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 MALONYL-COA DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000478 Malonyl-CoA Decarboxylase Deficiency ACSS1 DLD HIBCH LDHAL6B BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT MLYCD ACADM HYPOPHOSPHATASIA%SMPDB%SMP0000503 Hypophosphatasia PDXK PNPO ALPL AOX1 PDXP CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000480 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO HYPERORNITHINEMIA WITH GYRATE ATROPHY (HOGA)%PATHWHIZ%PW000481 Hyperornithinemia with Gyrate Atrophy (HOGA) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]%PATHWHIZ%PW000482 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome] EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY%PATHWHIZ%PW000483 L-Arginine:Glycine Amidinotransferase Deficiency EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO CHOLESTERYL ESTER STORAGE DISEASE%SMPDB%SMP0000508 Cholesteryl Ester Storage Disease ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS HYPER-IGD SYNDROME%SMPDB%SMP0000509 Hyper-IgD Syndrome ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS MEVALONIC ACIDURIA%SMPDB%SMP0000510 Mevalonic Aciduria ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS WOLMAN DISEASE%PATHWHIZ%PW000487 Wolman Disease ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS XANTHINURIA TYPE I%SMPDB%SMP0000512 Xanthinuria Type I PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 XANTHINURIA TYPE II%PATHWHIZ%PW000489 Xanthinuria Type II PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 GAMMA-CYSTATHIONASE DEFICIENCY (CTH)%PATHWHIZ%PW000490 gamma-Cystathionase Deficiency (CTH) CBS CTH HOMOCYSTINURIA, CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%PATHWHIZ%PW000491 Homocystinuria, Cystathionine beta-Synthase Deficiency CBS CTH ADRENOLEUKODYSTROPHY, X-LINKED%PATHWHIZ%PW000492 Adrenoleukodystrophy, X-Linked ABCD1 CRAT PEX13 PEX14 ABCD2 CPT2 ACSL1 SLC25A20 CROT PEX11G CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY%PATHWHIZ%PW000493 Carnitine-Acylcarnitine Translocase Deficiency ABCD1 CRAT PEX13 PEX14 ABCD2 CPT2 ACSL1 SLC25A20 CROT PEX11G GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000494 Glucose-6-phosphate Dehydrogenase Deficiency GPI G6PD RPE TALDO1 PGD DERA RPIA PFKL PGLS ALDOA PRPS1L1 TKT FBP1 PGM1 RBKS RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0000519 Ribose-5-phosphate Isomerase Deficiency GPI G6PD RPE TALDO1 PGD DERA RPIA PFKL PGLS ALDOA PRPS1L1 TKT FBP1 PGM1 RBKS TRANSALDOLASE DEFICIENCY%SMPDB%SMP0000520 Transaldolase Deficiency GPI G6PD RPE TALDO1 PGD DERA RPIA PFKL PGLS ALDOA PRPS1L1 TKT FBP1 PGM1 RBKS 3-HYDROXYISOBUTYRIC ACID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-HYDROXYISOBUTYRIC ACIDURIA%PATHWHIZ%PW000498 3-Hydroxyisobutyric Aciduria ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD ISOVALERIC ACIDEMIA%PATHWHIZ%PW000500 Isovaleric Acidemia ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD FABRY DISEASE%SMPDB%SMP0000525 Fabry Disease UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG KRABBE DISEASE%PATHWHIZ%PW000502 Krabbe Disease UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG HYPERLYSINEMIA I, FAMILIAL%PATHWHIZ%PW000503 Hyperlysinemia I, Familial GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS HYPERLYSINEMIA II OR SACCHAROPINURIA%PATHWHIZ%PW000504 Hyperlysinemia II or Saccharopinuria GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS D-GLYCERIC ACIDURA%PATHWHIZ%PW000505 D-Glyceric Acidura GPD1 LPL AKR1B1 AGPAT1 PLPP2 PLPP1 ALDH3A1 LIPC GPAM GPD2 GLYCTK FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY%PATHWHIZ%PW000506 Familial Lipoprotein Lipase Deficiency GPD1 LPL AKR1B1 AGPAT1 PLPP2 PLPP1 ALDH3A1 LIPC GPAM GPD2 GLYCTK GLYCOGENOSIS, TYPE VII. TARUI DISEASE%PATHWHIZ%PW000507 Glycogenosis, Type VII. Tarui Disease GPI PKLR PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK2 PGK1 GALM ALDOA GAPDH PFKM SULFITE OXIDASE DEFICIENCY%PATHWHIZ%PW000508 Sulfite Oxidase Deficiency SULT2B1 SULT1A1 CHST11 BPNT1 SUOX PAPSS2 MONOAMINE OXIDASE-A DEFICIENCY (MAO-A)%PATHWHIZ%PW000509 Monoamine Oxidase-A Deficiency (MAO-A) PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT G(M2)-GANGLIOSIDOSIS: VARIANT B, TAY-SACHS DISEASE%SMPDB%SMP0000534 G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT)%PATHWHIZ%PW000511 Adenine Phosphoribosyltransferase Deficiency (APRT) PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 MITOCHONDRIAL DNA DEPLETION SYNDROME-3%SMPDB%SMP0000536 Mitochondrial DNA Depletion Syndrome-3 PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 MYOADENYLATE DEAMINASE DEFICIENCY%PATHWHIZ%PW000513 Myoadenylate Deaminase Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY I%PATHWHIZ%PW000514 Carnitine Palmitoyl Transferase Deficiency I GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD)%PATHWHIZ%PW000515 Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS VERY-LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (VLCAD)%SMPDB%SMP0000540 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS CARNITINE PALMITOYL TRANSFERASE DEFICIENCY II%PATHWHIZ%PW000517 Carnitine Palmitoyl Transferase Deficiency II GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD)%PATHWHIZ%PW000518 Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%PATHWHIZ%PW000519 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) MTHFD1 MTHFD1L MTHFD2 FPGS MTHFR GGH MTHFS FTCD DHFR ALDH1L1 MTFMT SLC46A1 LONG-CHAIN-3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (LCHAD)%PATHWHIZ%PW000520 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD) HADHB HADHA ECHS1 ACAA2 MECR PPT1 HSD17B10 TRIFUNCTIONAL PROTEIN DEFICIENCY%SMPDB%SMP0000545 Trifunctional Protein Deficiency GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS CONGENITAL LACTIC ACIDOSIS%PATHWHIZ%PW000522 Congenital Lactic Acidosis CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 FUMARASE DEFICIENCY%SMPDB%SMP0000547 Fumarase Deficiency CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 MITOCHONDRIAL COMPLEX II DEFICIENCY%PATHWHIZ%PW000524 Mitochondrial Complex II Deficiency CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000525 2-Ketoglutarate Dehydrogenase Complex Deficiency CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 PYRUVATE DEHYDROGENASE DEFICIENCY (E3)%SMPDB%SMP0000550 Pyruvate Dehydrogenase Deficiency (E3) CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 PYRUVATE DEHYDROGENASE DEFICIENCY (E2)%SMPDB%SMP0000551 Pyruvate Dehydrogenase Deficiency (E2) CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW000528 Glycogen Synthetase Deficiency GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW000529 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0000554 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 GLYCOGENOSIS, TYPE VI. HERS DISEASE%PATHWHIZ%PW000531 Glycogenosis, Type VI. Hers Disease GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0000556 Mucopolysaccharidosis VII. Sly Syndrome GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW000533 Sucrase-Isomaltase Deficiency GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 PRIMARY HYPEROXALURIA II, PH2%SMPDB%SMP0000558 Primary Hyperoxaluria II, PH2 GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PYRUVATE KINASE DEFICIENCY%PATHWHIZ%PW000535 Pyruvate Kinase Deficiency GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0000560 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 FRUCTOSURIA%SMPDB%SMP0000561 Fructosuria ALDOA GFUS PHPT1 FBP1 PFKFB1 TPI1 PMM1 MPI SORD AKR1B1 HK1 KHK GMPPB PFKL GMDS FCSK FPGT ALDOB FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%SMPDB%SMP0000562 Fructose-1,6-diphosphatase Deficiency HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW000539 Triosephosphate Isomerase Deficiency HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM%SMPDB%SMP0000564 Multiple Carboxylase Deficiency, Neonatal or Early Onset Form BTD SPCS1 HLCS ACACB AROMATASE DEFICIENCY%SMPDB%SMP0000565 Aromatase Deficiency SRD5A1 HSD17B1 HSD3B1 AKR1D1 HSD17B3 UGT2B17 CYP19A1 CYP17A1 SULT2B1 UGT2B11 STS SULT1E1 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17)%PATHWHIZ%PW000542 17-alpha-Hydroxylase Deficiency (CYP17) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT SHORT-CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (SCHAD)%PATHWHIZ%PW000544 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD) ACSS3 ECHS1 ACAA2 ACADL HADH ACADS HSD17B10 ACAT1 SUCCINYL COA: 3-KETOACID COA TRANSFERASE DEFICIENCY%SMPDB%SMP0000569 Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency HMGCL BDH1 OXCT1 ACAT1 HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, CBLG COMPLEMENTATION TYPE%SMPDB%SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 PYRIDOXINE DEPENDENCY WITH SEIZURES%SMPDB%SMP0000571 Pyridoxine Dependency with Seizures GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS FANCONI-BICKEL SYNDROME%SMPDB%SMP0000572 Fanconi-Bickel Syndrome GPI PKLR PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK2 PGK1 GALM ALDOA GAPDH PFKM GLYCOGENOSIS, TYPE IB%SMPDB%SMP0000573 Glycogenosis, Type IB HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 GLYCOGENOSIS, TYPE IC%SMPDB%SMP0000574 Glycogenosis, Type IC HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1)%SMPDB%SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 21-HYDROXYLASE DEFICIENCY (CYP21)%SMPDB%SMP0000576 21-Hydroxylase Deficiency (CYP21) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 CORTICOSTERONE METHYL OXIDASE I DEFICIENCY (CMO I)%PATHWHIZ%PW000553 Corticosterone Methyl Oxidase I Deficiency (CMO I) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 CORTICOSTERONE METHYL OXIDASE II DEFICIENCY (CMO II)%SMPDB%SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 CONGENITAL DISORDER OF GLYCOSYLATION CDG-IID%PATHWHIZ%PW000555 Congenital Disorder of Glycosylation CDG-IId NME2 CMPK1 LALBA G6PC1 SLC35A2 GALT B4GALT1 UGP2 CANT1 SLC2A1 GLUT-1 DEFICIENCY SYNDROME%SMPDB%SMP0000580 GLUT-1 Deficiency Syndrome NME2 CMPK1 LALBA G6PC1 SLC35A2 GALT B4GALT1 UGP2 CANT1 SLC2A1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0000581 Glycogenosis, Type IA. Von Gierke Disease HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 JOUBERT SYNDROME%SMPDB%SMP0000582 Joubert Syndrome INPP4B PIKFYVE SYNJ1 INPP5D ERBB2 INPP5E PI4KA PIP4K2A PIP5K1A PIK3C3 CDIPT PLCB1 VAC14 BECN1 PTEN PIK3R4 PIK3CD PIK3R1 AMBRA1 PIK3C2A EGFR FIG4 BLUE DIAPER SYNDROME%SMPDB%SMP0000583 Blue Diaper Syndrome SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A LYSINURIC PROTEIN INTOLERANCE (LPI)%SMPDB%SMP0000585 Lysinuric Protein Intolerance (LPI) SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A COAGULATION%SMPDB%SMP0000586 Coagulation F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ANGIOTENSIN METABOLISM%SMPDB%SMP0000587 Angiotensin Metabolism ACE REN AGT STRIATED MUSCLE CONTRACTION%PATHWHIZ%PW000564 Striated Muscle Contraction SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN GASTRIC ACID PRODUCTION%SMPDB%SMP0000589 Gastric Acid Production SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 IBUPROFEN METABOLISM PATHWAY%PATHWHIZ%PW000566 Ibuprofen Metabolism Pathway PTGS2 PDIA6 PDIA4 PTGS1 HSP90B1 CYP2C9 CYP2C8 DNAJB11 ERP29 UGT2B4 UGT1A3 HYOU1 UGT1A9 PPIB SLC22A8 UGT2B7 PDIA2 UGT1A10 SLC22A6 SDF2L1 HSPA5 UGT1A1 CYP3A4 CYP2C19 BENAZEPRIL METABOLISM PATHWAY%SMPDB%SMP0000591 Benazepril Metabolism Pathway ACE CILAZAPRIL METABOLISM PATHWAY%SMPDB%SMP0000592 Cilazapril Metabolism Pathway ACE ENALAPRIL METABOLISM PATHWAY%SMPDB%SMP0000593 Enalapril Metabolism Pathway ACE FOSINOPRIL METABOLISM PATHWAY%SMPDB%SMP0000594 Fosinopril Metabolism Pathway ACE MOEXIPRIL METABOLISM PATHWAY%SMPDB%SMP0000595 Moexipril Metabolism Pathway ACE QUINAPRIL METABOLISM PATHWAY%SMPDB%SMP0000596 Quinapril Metabolism Pathway ACE RAMIPRIL METABOLISM PATHWAY%SMPDB%SMP0000597 Ramipril Metabolism Pathway ACE SPIRAPRIL METABOLISM PATHWAY%SMPDB%SMP0000598 Spirapril Metabolism Pathway ACE TRANDOLAPRIL METABOLISM PATHWAY%PATHWHIZ%PW000575 Trandolapril Metabolism Pathway ACE IRINOTECAN METABOLISM PATHWAY%SMPDB%SMP0000600 Irinotecan Metabolism Pathway UGT1A1 CYP3A4 CYP3A5 PDIA6 PDIA4 HSP90B1 SLCO1B1 DNAJB11 ERP29 HYOU1 TOP1 UGT1A9 PPIB CES2 CES1 ABCG2 BCHE PDIA2 UGT1A10 ABCC1 ABCB1 ABCC2 SDF2L1 HSPA5 ETOPOSIDE METABOLISM PATHWAY%PATHWHIZ%PW000577 Etoposide Metabolism Pathway PDIA6 PDIA4 PTGS1 HSP90B1 DNAJB11 ERP29 HYOU1 PPIB ABCC3 TOP2A TOP2B PDIA2 ABCB1 SDF2L1 HSPA5 UGT1A1 CYP3A4 PTGS2 MPO CYP3A5 TENIPOSIDE METABOLISM PATHWAY%SMPDB%SMP0000602 Teniposide Metabolism Pathway TOP2A CYP3A4 MPO CYP3A5 GEMCITABINE METABOLISM PATHWAY%PATHWHIZ%PW000579 Gemcitabine Metabolism Pathway RRM1 RRM2 CTPS1 TYMS DCK NME1 DCTD NT5C RRM2B CMPK1 SLC29A1 SLC28A1 SLC28A3 CYCLOPHOSPHAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000580 Cyclophosphamide Metabolism Pathway CYP3A4 CYP2C19 CYP2C9 ALDH3A1 CYP2C8 CYP2A6 GSTM1 CYP2B6 ALDH1A1 IFOSFAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000581 Ifosfamide Metabolism Pathway CYP2C9 ALDH3A1 CYP2C8 CYP2A6 CYP2B6 ALDH1A1 CYP3A4 CYP3A5 TAMOXIFEN METABOLISM PATHWAY%PATHWHIZ%PW000582 Tamoxifen Metabolism Pathway FMO3 CYP3A4 ESR1 CYP3A5 SULT1A1 UGT1A10 CYP2B6 CYP2D6 UGT1A4 FMO1 CAPECITABINE METABOLISM PATHWAY%SMPDB%SMP0000607 Capecitabine Metabolism Pathway CDA TYMS SLC28A1 TYMP CES1 FLUOROURACIL METABOLISM PATHWAY%SMPDB%SMP0000608 Fluorouracil Metabolism Pathway TYMS MERCAPTOPURINE METABOLISM PATHWAY%SMPDB%SMP0000609 Mercaptopurine Metabolism Pathway ABCC4 TPMT ABCC5 GMPS ADK IMPDH1 PPAT AOX1 HPRT1 RAC1 SLC28A2 SLC29A1 XDH SLC29A2 SLC28A3 CLOPIDOGREL METABOLISM PATHWAY%PATHWHIZ%PW000586 Clopidogrel Metabolism Pathway CYP2C19 CYP3A5 P2RY12 CYP2C9 ABCB1 CYP2B6 CYP1A2 PON1 CYP3A4 TICLOPIDINE METABOLISM PATHWAY%SMPDB%SMP0000611 Ticlopidine Metabolism Pathway P2RY12 ESOMEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000588 Esomeprazole Metabolism Pathway ATP4B ATP4A OMEPRAZOLE METABOLISM PATHWAY%SMPDB%SMP0000613 Omeprazole Metabolism Pathway ATP4B ATP4A LANSOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000590 Lansoprazole Metabolism Pathway ATP4B ATP4A PANTOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000591 Pantoprazole Metabolism Pathway ATP4B ATP4A RABEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000592 Rabeprazole Metabolism Pathway ATP4B ATP4A CIMETIDINE METABOLISM PATHWAY%PATHWHIZ%PW000593 Cimetidine Metabolism Pathway HRH2 FOSPHENYTOIN (ANTIARRHYTHMIC) METABOLISM PATHWAY%SMPDB%SMP0000618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway SCN5A SNTB1 SNTA1 SNTB2 FELODIPINE METABOLISM PATHWAY%SMPDB%SMP0000619 Felodipine Metabolism Pathway CACNB1 CACNA2D2 CACNA1C LIDOCAINE (LOCAL ANAESTHETIC) METABOLISM PATHWAY%SMPDB%SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway SCN10A CYP1A2 CYP3A4 SCN1B CODEINE METABOLISM PATHWAY%PATHWHIZ%PW000597 Codeine Metabolism Pathway CYP2D6 OPRM1 CYP3A4 UGT2B7 MORPHINE METABOLISM PATHWAY%SMPDB%SMP0000622 Morphine Metabolism Pathway UGT1A8 UGT2B7 PDIA2 SDF2L1 HSPA5 UGT1A1 UGT2B15 OPRM1 PDIA6 PDIA4 HSP90B1 DNAJB11 ERP29 UGT2B4 UGT1A3 HYOU1 PPIB HEROIN METABOLISM PATHWAY%PATHWHIZ%PW000599 Heroin Metabolism Pathway BCHE OPRM1 CES2 CES1 METHADONE METABOLISM PATHWAY%SMPDB%SMP0000624 Methadone Metabolism Pathway CYP3A4 CYP2C19 CYP3A7 GRIN1 CYP2C8 GRIN2A CYP2B6 GRIN3A CYP2D6 OPRM1 IMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000601 Imipramine Metabolism Pathway CYP2D6 CYP1A2 CYP3A4 CYP2C19 SLC6A2 SLC6A4 DESIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000602 Desipramine Metabolism Pathway CYP2D6 SLC6A2 SLC6A4 CITALOPRAM METABOLISM PATHWAY%PATHWHIZ%PW000603 Citalopram Metabolism Pathway MAOB CYP2D6 MAOA AOX1 CYP2C19 CYP3A7 SLC6A4 NICOTINE METABOLISM PATHWAY%PATHWHIZ%PW000604 Nicotine Metabolism Pathway FMO3 UGT1A9 CHRNB2 CYP2A6 CHRNA3 CYP2B6 CHRNA4 UGT1A4 AOX1 ADEFOVIR DIPIVOXIL METABOLISM PATHWAY%PATHWHIZ%PW000605 Adefovir Dipivoxil Metabolism Pathway AK1 NME2 AK2 NME1 TENOFOVIR METABOLISM PATHWAY%PATHWHIZ%PW000606 Tenofovir Metabolism Pathway AK1 NME2 AK2 NME1 PREDNISONE METABOLISM PATHWAY%PATHWHIZ%PW000607 Prednisone Metabolism Pathway CYP3A4 PREDNISOLONE METABOLISM PATHWAY%PATHWHIZ%PW000608 Prednisolone Metabolism Pathway HSP90AA1 NR3C1 FELBAMATE METABOLISM PATHWAY%SMPDB%SMP0000633 Felbamate Metabolism Pathway ALDH3A1 ADH1A CYP2E1 CYP3A4 CARBAMAZEPINE METABOLISM PATHWAY%PATHWHIZ%PW000610 Carbamazepine Metabolism Pathway CYP2C8 CYP2B6 EPHX1 CYP3A4 CYP2C19 CYP3A5 CYP3A7 VALPROIC ACID METABOLISM PATHWAY%SMPDB%SMP0000635 Valproic Acid Metabolism Pathway IVD EHHADH ACSM1 UGT1A3 ACADSB HSD17B10 HADHB CYP2C9 HADHA CYP2A6 CYP2B6 VENLAFAXINE METABOLISM PATHWAY%PATHWHIZ%PW000612 Venlafaxine Metabolism Pathway ABCB1 CYP2D6 CYP3A4 CYP2C19 SLC6A2 SLC6A4 TRAMADOL METABOLISM PATHWAY%PATHWHIZ%PW000613 Tramadol Metabolism Pathway CYP2B6 ABCC2 CYP2D6 SLC22A1 CYP3A4 UGT1A8 UGT2B7 LEVOMETHADYL ACETATE METABOLISM PATHWAY%PATHWHIZ%PW000614 Levomethadyl Acetate Metabolism Pathway CYP3A7 CLOMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000615 Clomipramine Metabolism Pathway CYP2D6 CYP1A2 CYP3A4 CYP2C19 ACETAMINOPHEN METABOLISM PATHWAY%PATHWHIZ%PW000616 Acetaminophen Metabolism Pathway ABCB1 GSTP1 GSTT1 CYP3A4 HSP90B1 SULT1A1 SULT1E1 CYP2D6 UGT1A9 SULT1A4 UGT1A6 SULT2A1 ABCC4 PDIA2 ABCC1 SDF2L1 HSPA5 UGT1A1 ABCC5 UGT2B15 PDIA6 PDIA4 CYP2A6 CYP1A2 DNAJB11 ERP29 HYOU1 CYP2E1 PPIB ABCG2 DOXEPIN METABOLISM PATHWAY%PATHWHIZ%PW000617 Doxepin Metabolism Pathway CYP2C9 CYP2D6 CYP1A2 CYP3A4 CYP2C19 NEVIRAPINE METABOLISM PATHWAY%PATHWHIZ%PW000618 Nevirapine Metabolism Pathway CYP2C9 UGT1A10 CYP2B6 CYP2D6 ALDH1A1 CYP3A4 ABCC10 CYP3A5 CELECOXIB METABOLISM PATHWAY%SMPDB%SMP0000644 Celecoxib Metabolism Pathway CYP2C9 UGT1A10 ADH1B CYP2D6 ADH1A CYP3A4 PTGS2 PTGS1 FLUOXETINE METABOLISM PATHWAY%SMPDB%SMP0000646 Fluoxetine Metabolism Pathway CYP2C9 CYP2D6 CYP3A4 CYP2C19 CYP3A5 SLC6A4 THIOGUANINE METABOLISM PATHWAY%PATHWHIZ%PW000623 Thioguanine Metabolism Pathway HPRT1 SORAFENIB METABOLISM PATHWAY%PATHWHIZ%PW000624 Sorafenib Metabolism Pathway PDIA2 SDF2L1 HSPA5 UGT1A1 CYP3A4 PDIA6 PDIA4 HSP90B1 CYP2C9 CYP2C8 CYP2B6 DNAJB11 ERP29 HYOU1 UGT1A9 PPIB LAMIVUDINE METABOLISM PATHWAY%PATHWHIZ%PW000625 Lamivudine Metabolism Pathway PGK1 CMPK1 CHPT1 ABCG2 ABCC3 ABCC4 SLC22A3 ABCC1 ABCB1 PCYT1A ABCC2 PCYT2 SLC22A2 SLC22A1 DCK NME1 SULT1A1 NT5C DOXORUBICIN METABOLISM PATHWAY%SMPDB%SMP0000650 Doxorubicin Metabolism Pathway CBR3 ABCG2 NQO1 CBR1 ABCC1 RALBP1 ABCB1 ABCC2 NOS3 AKR1A1 AKR1C3 POR NDUFS7 SLC22A16 NDUFS3 NDUFS2 XDH ARTEMETHER METABOLISM PATHWAY%PATHWHIZ%PW000627 Artemether Metabolism Pathway UGT1A9 CYP3A4 CYP3A5 UGT2B7 MYCOPHENOLIC ACID METABOLISM PATHWAY%PATHWHIZ%PW000628 Mycophenolic Acid Metabolism Pathway ABCB1 ABCC2 CYP3A4 CYP3A5 SLCO1B1 CYP2C8 IMPDH1 IMPDH2 SLCO1B3 UGT1A9 UGT1A8 CES2 UGT2B7 UGT1A7 CES1 ABCG2 ROSIGLITAZONE METABOLISM PATHWAY%PATHWHIZ%PW000629 Rosiglitazone Metabolism Pathway CYP2C9 SLCO1B1 CYP2C8 WARBURG EFFECT%PATHWHIZ%PW000630 Warburg Effect PDHA1 SLC16A1 PKLR MDH1 IDH3G IDH1 PGAM2 TALDO1 SDHC SDHD SDHA PGD SDHB CS RPIA GLUD1 PFKL PC PKM SUCLG2 ACO1 SUCLG1 ALDOB ACO2 TKT GAPDH DLD GPI FH GLS2 SLC2A2 DLST ENO1 PDHB SLC1A5 HK2 DHTKD1 LDHA MPC1 IDH3B PGK1 PGLS DLAT IDH3A G6PD PHENINDIONE ACTION PATHWAY%SMPDB%SMP0000655 Phenindione Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 DICOUMAROL ACTION PATHWAY%PATHWHIZ%PW000632 Dicoumarol Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 BOPINDOLOL ACTION PATHWAY%SMPDB%SMP0000657 Bopindolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN CARTEOLOL ACTION PATHWAY%PATHWHIZ%PW000634 Carteolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN TIMOLOL ACTION PATHWAY%PATHWHIZ%PW000636 Timolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN SOTALOL ACTION PATHWAY%SMPDB%SMP0000660 Sotalol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN EPINEPHRINE ACTION PATHWAY%PATHWHIZ%PW000638 Epinephrine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN DOBUTAMINE ACTION PATHWAY%PATHWHIZ%PW000639 Dobutamine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ISOPRENALINE ACTION PATHWAY%SMPDB%SMP0000663 Isoprenaline Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ARBUTAMINE ACTION PATHWAY%SMPDB%SMP0000664 Arbutamine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN AMIODARONE ACTION PATHWAY%PATHWHIZ%PW000642 Amiodarone Action Pathway CHRM2 RYR2 ATP2A2 SLC8A1 PRKACG SCN5A PRKACA PRKACB SNTA1 KCNH2 ABCC8 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 PRKAR1B PRKAR1A KCNQ1 ALG10B HCN4 KCNE1 KCNE2 ATP1A4 ATP1A3 UQCR11 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H CACNA1G SLC9A1 PLN PRKAR2B PRKAR2A KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ11 KCNJ8 KCNIP2 DLG1 FXYD2 GNAS KCNK1 SNTB1 MCU SNTB2 LEVOBUNOLOL ACTION PATHWAY%SMPDB%SMP0000666 Levobunolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN METIPRANOLOL ACTION PATHWAY%PATHWHIZ%PW000644 Metipranolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BEVANTOLOL ACTION PATHWAY%PATHWHIZ%PW000645 Bevantolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PRACTOLOL ACTION PATHWAY%PATHWHIZ%PW000646 Practolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BUPRANOLOL ACTION PATHWAY%SMPDB%SMP0000670 Bupranolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN TRAMADOL ACTION ACTION PATHWAY%SMPDB%SMP0000671 Tramadol Action Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PROPOXYPHENE ACTION PATHWAY%PATHWHIZ%PW000649 Propoxyphene Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LEVORPHANOL ACTION PATHWAY%SMPDB%SMP0000673 Levorphanol Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ANILERIDINE ACTION PATHWAY%SMPDB%SMP0000674 Anileridine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DIPHENOXYLATE ACTION PATHWAY%SMPDB%SMP0000675 Diphenoxylate Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DEZOCINE ACTION PATHWAY%PATHWHIZ%PW000653 Dezocine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LEVOMETHADYL ACETATE ACTION ACTION PATHWAY%SMPDB%SMP0000677 Levomethadyl Acetate Action Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 METHADYL ACETATE ACTION PATHWAY%PATHWHIZ%PW000655 Methadyl Acetate Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 3-METHYLTHIOFENTANYL ACTION PATHWAY%PATHWHIZ%PW000656 3-Methylthiofentanyl Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DIMETHYLTHIAMBUTENE ACTION PATHWAY%SMPDB%SMP0000680 Dimethylthiambutene Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ETHYLMORPHINE ACTION PATHWAY%SMPDB%SMP0000681 Ethylmorphine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LEUCINE STIMULATION ON INSULIN SIGNALING%SMPDB%SMP0000682 Leucine Stimulation on Insulin Signaling IRS1 INSR TSC2 TSC1 IRS2 MTOR PIK3CG PIK3R6 INS SLC7A5 RPS6KB1 RHEB EIF4EBP1 AKT1 EIF4E LEVALLORPHAN ACTION PATHWAY%SMPDB%SMP0000683 Levallorphan Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 BUPRENORPHINE ACTION PATHWAY%SMPDB%SMP0000684 Buprenorphine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ALVIMOPAN ACTION PATHWAY%SMPDB%SMP0000685 Alvimopan Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PENTAZOCINE ACTION PATHWAY%SMPDB%SMP0000686 Pentazocine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 NALTREXONE ACTION PATHWAY%PATHWHIZ%PW000664 Naltrexone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 NALOXONE ACTION PATHWAY%SMPDB%SMP0000688 Naloxone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DIHYDROMORPHINE ACTION PATHWAY%PATHWHIZ%PW000666 Dihydromorphine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 KETOBEMIDONE ACTION PATHWAY%SMPDB%SMP0000690 Ketobemidone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 NALBUPHINE ACTION PATHWAY%SMPDB%SMP0000691 Nalbuphine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 OPRK1 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ANTIPYRINE ACTION PATHWAY%SMPDB%SMP0000692 Antipyrine Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ANTRAFENINE ACTION PATHWAY%SMPDB%SMP0000693 Antrafenine Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES CARPROFEN ACTION PATHWAY%SMPDB%SMP0000694 Carprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ETORICOXIB ACTION PATHWAY%SMPDB%SMP0000695 Etoricoxib Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES FENOPROFEN ACTION PATHWAY%SMPDB%SMP0000696 Fenoprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES FLURBIPROFEN ACTION PATHWAY%SMPDB%SMP0000697 Flurbiprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES MAGNESIUM SALICYLATE ACTION PATHWAY%PATHWHIZ%PW000675 Magnesium Salicylate Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES LUMIRACOXIB ACTION PATHWAY%SMPDB%SMP0000699 Lumiracoxib Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES LORNOXICAM ACTION PATHWAY%PATHWHIZ%PW000677 Lornoxicam Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES PHENYLBUTAZONE ACTION PATHWAY%PATHWHIZ%PW000678 Phenylbutazone Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES NEPAFENAC ACTION PATHWAY%PATHWHIZ%PW000679 Nepafenac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TRISALICYLATE-CHOLINE ACTION PATHWAY%PATHWHIZ%PW000680 Trisalicylate-Choline Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TOLMETIN ACTION PATHWAY%PATHWHIZ%PW000681 Tolmetin Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TIAPROFENIC ACID ACTION PATHWAY%PATHWHIZ%PW000682 Tiaprofenic Acid Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TENOXICAM ACTION PATHWAY%SMPDB%SMP0000706 Tenoxicam Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES SALSALATE ACTION PATHWAY%SMPDB%SMP0000707 Salsalate Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES SALICYLATE-SODIUM ACTION PATHWAY%SMPDB%SMP0000708 Salicylate-Sodium Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES SALICYLIC ACID ACTION PATHWAY%SMPDB%SMP0000709 Salicylic Acid Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ACETAMINOPHEN ACTION PATHWAY%SMPDB%SMP0000710 Acetaminophen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TOBRAMYCIN ACTION PATHWAY%PATHWHIZ%PW000688 Tobramycin Action Pathway rplS TIGECYCLINE ACTION PATHWAY%PATHWHIZ%PW000689 Tigecycline Action Pathway rplS ARBEKACIN ACTION PATHWAY%PATHWHIZ%PW000690 Arbekacin Action Pathway rplS PAROMOMYCIN ACTION PATHWAY%PATHWHIZ%PW000691 Paromomycin Action Pathway rplS METHYLHISTIDINE METABOLISM%PATHWHIZ%PW000692 Methylhistidine Metabolism ACTB THYROID HORMONE SYNTHESIS%PATHWHIZ%PW000693 Thyroid Hormone Synthesis CYBA DUOX2 SLC5A5 DUOX1 TPO TG NOX3 CYBB NOX4 APPARENT MINERALOCORTICOID EXCESS SYNDROME%SMPDB%SMP0000717 Apparent Mineralocorticoid Excess Syndrome CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA%SMPDB%SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS 27-HYDROXYLASE DEFICIENCY%PATHWHIZ%PW000697 27-Hydroxylase Deficiency ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 CYSTINOSIS, OCULAR NONNEPHROPATHIC%PATHWHIZ%PW000699 Cystinosis, Ocular Nonnephropathic CARS1 CDO1 MPST LDHA GCLC GOT1 CTH CTNS GCLM CYSTINURIA%PATHWHIZ%PW000700 Cystinuria SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A FOLATE MALABSORPTION, HEREDITARY%PATHWHIZ%PW000701 Folate Malabsorption, Hereditary MTHFD1 MTHFD1L MTHFD2 FPGS MTHFR GGH MTHFS FTCD DHFR ALDH1L1 MTFMT SLC46A1 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW000702 Fructose Intolerance, Hereditary ALDOA GFUS PHPT1 FBP1 PFKFB1 TPI1 PMM1 MPI SORD AKR1B1 HK1 KHK GMPPB PFKL GMDS FCSK FPGT ALDOB TEMOCAPRIL ACTION PATHWAY%PATHWHIZ%PW000710 Temocapril Action Pathway ACE REN AGT ROXATIDINE ACETATE ACTION PATHWAY%PATHWHIZ%PW000711 Roxatidine Acetate Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 METIAMIDE ACTION PATHWAY%PATHWHIZ%PW000712 Metiamide Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 BETAZOLE ACTION PATHWAY%PATHWHIZ%PW000713 Betazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%PATHWHIZ%PW000726 Activation of PKC Through G Protein-Coupled Receptor GNAQ ITPR1 PRKCA PLCB1 GLYCOLYSIS AND PYRUVATE DEHYDROGENASE%SMPDB%SMP0000807 Glycolysis and Pyruvate Dehydrogenase aceF mtlA pykF fbaB pgi fbaA pgk fbp yggF gpmI pfkA pfkB ybhA ppsA gapA glpX tpiA crr eno pykA mtlD ptsG ptsH gpmA GLUCONEOGENESIS FROM L-MALIC ACID%SMPDB%SMP0000839 Gluconeogenesis from L-Malic Acid fbp yggF gpmI ybhA ppsA gapA glpX pckA dctA tpiA dcuB maeB dcuC maeA dcuA eno fbaB pgi fbaA pgk GALACTITOL AND GALACTONATE DEGRADATION%SMPDB%SMP0000840 Galactitol and Galactonate Degradation kbaZ dgoT ptsH gatY gatZ dgoK gatA dgoD gatB pfkB gatC gatD dgoA kbaY GLYCOLYSIS%PATHWHIZ%PW000839 Glycolysis At4g37840 CTIMC MSSP1 PKP4 FBA1 GAPB FRUCTOSE METABOLISM%PATHWHIZ%PW000913 Fructose Metabolism tpiA eno fruA fruB pykA gpmA ptsI pykF fbaB fruK fbaA pgk gpmI ppsA gapA GLYCEROL METABOLISM%PATHWHIZ%PW000914 Glycerol Metabolism tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT glpX GLYCEROL METABOLISM II%PATHWHIZ%PW000915 Glycerol Metabolism II tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW000916 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT glpX GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%PATHWHIZ%PW000917 Glycerol Metabolism IV (Glycerophosphoglycerol) tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT glpX GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%PATHWHIZ%PW000918 Glycerol Metabolism V (Glycerophosphoserine) tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT glpX THE ONCOGENIC ACTION OF 2-HYDROXYGLUTARATE%SMPDB%SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate FH GLS2 gdhA DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 ACO1 SUCLG1 ACO2 DLD THE ONCOGENIC ACTION OF SUCCINATE%PATHWHIZ%PW002360 The Oncogenic Action of Succinate FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A EGLN1 EGLN3 PDHA1 EGLN2 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 ACO1 SUCLG1 SLC25A10 ACO2 DLD THE ONCOGENIC ACTION OF FUMARATE%PATHWHIZ%PW002363 The Oncogenic Action of Fumarate FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A EGLN1 EGLN3 PDHA1 EGLN2 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 ACO1 SUCLG1 SLC25A10 ACO2 DLD GLUTAMINOLYSIS AND CANCER%SMPDB%SMP0002298 Glutaminolysis and Cancer PC SLC7A7 SUCLG2 SUCLG1 ACO2 DLD alaC FH MYCBP GLS2 alaA DLST SLC1A4 PDHB SLC1A5 DHTKD1 LDHA MPC1 IDH3B ME1 DLAT SLC38A5 IDH3A PDHA1 SLC16A1 IDH3G GOT2 IDH2 SDHC SDHD SDHA SDHB CS GLUD1 ACLY GLYCOLYSIS I%SMPDB%SMP0002312 Glycolysis I CDC19 PGI1 TDH1 GPM2 EMI2 YOR283W TPI1 MAL11 YNR071C PFK1 SARCOSINE ONCOMETABOLITE PATHWAY%SMPDB%SMP0002313 Sarcosine Oncometabolite Pathway DMGDH SLC44A1 SHMT2 SLC44A2 SHMT1 MTR MAT2B GNMT BHMT MAT2A CHDH SARDH ALDH7A1 FRUCTOSE METABOLISM%PATHWHIZ%PW002390 Fructose Metabolism PGI1 SOR1 FBP26 PFK26 EMI2 PFK27 HXK1 HXK2 SUC2 ETHANOL FERMENTATION%SMPDB%SMP0002356 Ethanol Fermentation PDC6 TPI1 PDC5 MAL11 PDC1 YNR071C ADH7 ADH6 GPM2 EMI2 YOR283W PFK1 CDC19 PGI1 TDH1 THE ONCOGENIC ACTION OF L-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%PATHWHIZ%PW002451 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria FH GLS2 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS GLUD1 PC SUCLG2 ACO1 SUCLG1 ACO2 L2HGDH DLD THE ONCOGENIC ACTION OF D-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%SMPDB%SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria FH GLS2 DLST PDHB DHTKD1 MPC1 IDH3B D2HGDH DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS GLUD1 PC SUCLG2 ACO1 SUCLG1 ACO2 L2HGDH DLD STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW002481 Starch and Sucrose Metabolism ATH1 TSL1 GSY2 GSY1 GLK1 NTH1 EMI2 GLC3 NTH2 SUC2 PGI1 SPR1 GSC2 TPS3 NGK1 TPS2 EXG1 TPS1 EXG2 PRM15 FKS1 FKS3 YHL012W HXK1 BGL2 HXK2 ROT2 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW002495 Inositol Phosphate Metabolism ARG82 INM1 INP51 IPK1 INOSITOL METABOLISM%SMPDB%SMP0002397 Inositol Metabolism INM1 VPS15 INP51 PLC1 INP52 VAC14 VPS30 FAB1 PIK1 VPS34 GLUCONEOGENESIS FROM L-MALIC ACID%PATHWHIZ%PW002518 Gluconeogenesis from L-Malic Acid MDH1 CTIMC NAD-ME1 FLAVONOID BIOSYNTHESIS%SMPDB%SMP0012021 Flavonoid Biosynthesis CYP98A3 F3H CYP73A5 DFRA CHS BAN CHI1 LDOX CCOAOMT1 CYP75B1 HST PHOTOSYNTHESIS%SMPDB%SMP0012089 Photosynthesis ALB3 PSB27-1 PSAH2 PSAE1 PSB28 PSBO1 CFBP1 ATPC1 petC petD PSBS PSBR petA PSBW At1g32060 GAPA1 psbT PPD1 RBCS-1A PSAK psaD1 PSAL rbcL PSAG PSAF PSBP1 psbC YMF19 psbD PSBQ1 psbE psbF PSAO PSAN psbA psbB psbK PGK1 psbL psbM TKL-1 At3g55800 psbH psbI psbJ RPI1 atpI atpE atpH atpB atpA FBA1 At1g63290 psaB psaC psaA psaJ TIM ATPD LFNR1 DRT112 psaI CALVIN-BENSON CYCLE%PATHWHIZ%PW012957 Calvin-Benson Cycle GAPA1 RBCS-1A PGK1 TIM TKL-1 rbcL At3g55800 FBA1 At1g63290 CFBP1 RPI1 At1g32060 FRUCTOSE METABOLISM%SMPDB%SMP0012445 Fructose Metabolism CYFBP CTIMC PFK1 PFP-ALPHA1 PFP-BETA1 At2g31390 FBA4 XYLA At1g48430 FKFBP HXK1 SDH PHOSPHATIDYLCHOLINE BIOSYNTHESIS%SMPDB%SMP0014212 Phosphatidylcholine Biosynthesis PCYT1A PCYT2 CHKA PEMT CEPT1 PISD DE NOVO TRIACYLGLYCEROL BIOSYNTHESIS%SMPDB%SMP0015896 De Novo Triacylglycerol Biosynthesis DGAT1 GPAM GPD1 LPIN1 AGPAT1 CARDIOLIPIN BIOSYNTHESIS%SMPDB%SMP0020986 Cardiolipin Biosynthesis PGS1 AGPAT5 GPAM PTPMT1 GPD1 CRLS1 CDS2 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS%SMPDB%SMP0029731 Phosphatidylethanolamine Biosynthesis PTDSS1 PCYT2 CHKA CEPT1 PISD ANDROSTENEDIONE METABOLISM%SMPDB%SMP0030406 Androstenedione Metabolism DNAJB11 ERP29 HYOU1 PPIB PDIA2 SDF2L1 HSPA5 UGT1A1 SRD5A1 AKR1D1 HSD17B3 AKR1C4 CYP19A1 PDIA6 PDIA4 HSP90B1 HSD11B1 CYP11B1 ESTRONE METABOLISM%SMPDB%SMP0030880 Estrone Metabolism PDIA2 SDF2L1 HSPA5 UGT1A1 COMT CYP3A5 PDIA6 PDIA4 HSP90B1 SULT1E1 HSD17B1 DNAJB11 CYP1A1 ERP29 HYOU1 PPIB BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692 BCR-ABL Action in CML Pathogenesis JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694 Imatinib Inhibition of BCR-ABL MYC BCR-ABL1 MDM2 GRB2 JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A ABCB1 CDKN1B BAD SLC22A1 PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594 Dasatinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595 Nilotinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596 Bosutinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597 Bafetinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598 Ponatinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 LAFUTIDINE H2-ANTIHISTAMINE ACTION%PATHWHIZ%PW051946 Lafutidine H2-Antihistamine Action SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 CHLORPHENAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW057579 Chlorphenamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056662 Pheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DEXCHLORPHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056811 Dexchlorpheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058500 Brompheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DEXBROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058503 Dexbrompheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TRIPROLIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057581 Triprolidine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DIMETINDENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057582 Dimetindene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MEPYRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057583 Mepyramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ANTAZOLINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057584 Antazoline H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CHLOROPYRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058510 Chloropyramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TALASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058511 Talastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TRIPELENNAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057587 Tripelennamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HISTAPYRRODINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058732 Histapyrrodine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 METHAPYRILENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058741 Methapyrilene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THONZYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059696 Thonzylamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058785 Diphenhydramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CARBINOXAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058797 Carbinoxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DOXYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059730 Doxylamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ORPHENADRINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059735 Orphenadrine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BROMODIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059740 Bromodiphenhydramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CLEMASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059823 Clemastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CHLORPHENOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059836 Chlorphenoxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DIPHENYLPYRALINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059841 Diphenylpyraline H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENYLTOLOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059850 Phenyltoloxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059857 Cyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058931 Chlorcyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HYDROXYZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058936 Hydroxyzine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MECLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059891 Meclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BUCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058964 Buclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 OXATOMIDE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059044 Oxatomide H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059995 Cetirizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CINNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059110 Cinnarizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LEVOCETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060053 Levocetirizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PROMETHAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060150 Promethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ALIMEMAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059689 Alimemazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CYPROHEPTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059694 Cyproheptadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENBENZAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060645 Phenbenzamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FENETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059707 Fenethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HYDROXYETHYLPROMETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ISOTHIPENDYL H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060659 Isothipendyl H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MEQUITAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059720 Mequitazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 METHDILAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059730 Methdilazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 OXOMEMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060682 Oxomemazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 AZATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059865 Azatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 KETOTIFEN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060812 Ketotifen H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DOXEPIN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060816 Doxepin H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ACRIVASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060826 Acrivastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ASTEMIZOLE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059897 Astemizole H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BEPOTASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060058 Bepotastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BILASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061119 Bilastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LORATADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061144 Loratadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DESLORATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060201 Desloratadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EBASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061153 Ebastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TERFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061157 Terfenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FEXOFENADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060218 Fexofenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LEVOCABASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060224 Levocabastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MIZOLASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060230 Mizolastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 RUPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060235 Rupatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 OLOPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060740 Olopatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 AZELASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060741 Azelastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THIAZINAMIUM H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061692 Thiazinamium H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 QUIFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061693 Quifenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BETAHISTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061694 Betahistine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EMEDASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061990 Emedastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FLUNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061047 Flunarizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MEBHYDROLIN H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061052 Mebhydrolin H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENINDAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062141 Phenindamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EPINASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062142 Epinastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TOLPROPAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062621 Tolpropamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EMBRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062622 Embramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LATREPIRDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062623 Latrepirdine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THENYLDIAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062624 Thenyldiamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PROPIOMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063580 Propiomazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CLOCINIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062788 Clocinizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HOMOCHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063751 Homochlorcyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TEMELASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063837 Temelastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ALCAFTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062881 Alcaftadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BAMIPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062882 Bamipine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DEPTROPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062883 Deptropine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 QUETIAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062884 Quetiapine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MIRTAZAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062885 Mirtazapine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PIMETHIXENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062886 Pimethixene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PYRROBUTAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062887 Pyrrobutamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THENALIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062894 Thenalidine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TRITOQUALINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062895 Tritoqualine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HISTAMINE H1 RECEPTOR ACTIVATION%SMPDB%SMP0063452 Histamine H1 Receptor Activation HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 GLYCOLYSIS%SMPDB%SMP0063478 Glycolysis Slc2a13 Gpi Tpi1 Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pkm Pgam1 Galm Pgk2 Pfkp PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW064563 Pentose Phosphate Pathway Gpi H6pd Rpe Prpsap1 Taldo1 Aldob Pgd Rpia Dera Tktl1 Pfkm Rbks Fbp2 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0063614 Fructose and Mannose Degradation Tpi1 Aldob Aldoc Pfkm Hk1 Fbp2 GLUCONEOGENESIS%PATHWHIZ%PW064594 Gluconeogenesis Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 INOSITOL METABOLISM%PATHWHIZ%PW064607 Inositol Metabolism Pik3cd Inppl1 Zfyve16 Pik3r4 Prex1 Vac14 Inpp5f Ptpmt1 Plce1 Pik3c3 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0063630 Inositol Phosphate Metabolism Prex1 Ipmk Inppl1 Nudt10 STARCH AND SUCROSE METABOLISM%SMPDB%SMP0063673 Starch and Sucrose Metabolism Gpi Ugt8 Gusb Hk1 LYSOPHOSPHATIDIC ACID LPA1 SIGNALLING%SMPDB%SMP0063746 Lysophosphatidic Acid LPA1 Signalling ADCY1 PLCB1 GNG2 ROCK1 SRF GNB1 ITPR1 LPAR1 AKT1 LYSOPHOSPHATIDIC ACID LPA2 SIGNALLING%SMPDB%SMP0063753 Lysophosphatidic Acid LPA2 Signalling ADCY1 PLCB1 GNG2 ROCK1 SRF GNB1 ITPR1 AKT1 LPAR2 LYSOPHOSPHATIDIC ACID LPA3 SIGNALLING%SMPDB%SMP0063755 Lysophosphatidic Acid LPA3 Signalling GNG2 GNB1 ITPR1 GNAS AKT1 LPAR3 ADCY1 PLCB1 LYSOPHOSPHATIDIC ACID LPA4 SIGNALLING%SMPDB%SMP0063756 Lysophosphatidic Acid LPA4 Signalling AKT1 ADCY1 LPAR4 PLCB1 GNG2 ROCK1 SRF GNB1 ITPR1 GNAS LYSOPHOSPHATIDIC ACID LPA5 SIGNALLING%SMPDB%SMP0063757 Lysophosphatidic Acid LPA5 Signalling GNAS AKT1 ADCY1 PLCB1 GNG2 ROCK1 LPAR5 SRF GNB1 ITPR1 LYSOPHOSPHATIDIC ACID LPA6 SIGNALLING%PATHWHIZ%PW064749 Lysophosphatidic Acid LPA6 Signalling GNG2 ROCK1 LPAR6 SRF GNB1 GNAS AKT1 ADCY1 ACTIVATION OF CAMP-DEPENDENT PROTEIN KINASE, PKA%SMPDB%SMP0063764 Activation of cAMP-dependent protein kinase, PKA PRKAR2B PRKAR2A PRKACG GNB1 GNAS PRKACA PRKACB GNGT1 ADCY10 PRKAR1B PRKAR1A AHR SIGNAL TRANSDUCTION PATHWAY%PATHWHIZ%PW064763 Ahr Signal Transduction Pathway HSP90AA1 ARNT AHR APOPTOTIC DNA FRAGMENTATION AND TISSUE HOMEOSTASIS%SMPDB%SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis GZMB HMGB1 TOP2A DFFA CASP7 ENDOG CASP3 CAD HMGB2 BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773 BTG Family Proteins and Cell Cycle Regulation PRMT1 NGF FGF1 TP53 RB1 BTG2 HOXB9 BTG1 CHAF1A CCND1 NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0063777 Nitric Oxide Signaling Pathway DLG4 ITPR1 PRKCA NOS1 CALM1 PRKACB XDH GRIN1 PPP3CA GRIN2A GRIN3A ALDH2 ION CHANNELS AND THEIR FUNCTIONAL ROLE IN VASCULAR ENDOTHELIUM%SMPDB%SMP0063778 Ion Channels and Their Functional Role in Vascular Endothelium TRPC7 GUCY1A2 GUCY1B2 GUCY1A1 GUCY1B1 TRPC3 NOS3 TRPC4 ADCY10 TRPV4 KCNQ2 KCNQ3 KCNQ4 PRKG2 KCNQ5 PRKG1 P53 SIGNALING PATHWAY%PATHWHIZ%PW064774 P53 Signaling Pathway RB1 CDKN1A PCNA APAF1 GADD45B CCNB1 CCND1 CDK4 CCNE1 CDK2 CDK1 BCL2 E2F1 BAX PHOSPHOLIPASE C SIGNALING PATHWAY%SMPDB%SMP0063783 Phospholipase C Signaling Pathway AKT1 PRKCA PLCG1 PLCB1 VAV1 PIK3CG PIK3R6 RAS SIGNALING PATHWAY%SMPDB%SMP0063784 Ras Signaling Pathway BAD FOXO4 PLD1 ELK1 RHOA CASP9 CDC42 PIK3CA AKT1 CYCS RAC1 RAF1 HRAS RALGDS MAPK3 BCL2L1 VAV3 RALA MAP2K1 SMAD4 RALBP1 SMAD3 APAF1 CHUK TNF STRESS RELATED SIGNALING%PATHWHIZ%PW064784 TNF Stress Related Signaling MAPK14 TNF TANK NFKB1 IKBKB NFKBIA MAPK8 CASP2 RIPK1 IKBKG MAP2K7 MAP2K6 ATF1 MAP2K3 MAP2K4 MAP4K2 JUN MAP3K1 CHUK CRADD TRADD TRAF2 RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795 Rac 1 Cell Motility Signaling Pathway MYLK CCND3 PAK1 RPS6KB1 CCND1 CDK5 MYL2 CFL1 ARFIP2 RAC1 PPP1R12B WASF1 CAP1 VAV3 PDGFRA CDKN1A RALBP1 PCNA MAP3K1 LIMK1 PLD1 ACTB CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%SMPDB%SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages MAP2K1 PRKCB ITPR1 PRKCA CACNA1D CACNA1C CACNA1F NFKB1 RELA NFKBIA MAPK1 CACNA1S RAF1 PLCB1 HRAS MAPK3 GROWTH HORMONE SIGNALING PATHWAY%PATHWHIZ%PW064811 Growth Hormone Signaling Pathway GH1 SOCS1 RPS6KA1 MAPK1 PTPN6 GRB2 PLCG1 JAK2 RAF1 SOS1 HRAS MAPK3 STAT5A STAT5B MAP2K1 SHC1 IRS1 INSR PRKCA SLC2A4 INS GHR EGF SIGNALLING PATHWAY%SMPDB%SMP0063810 EGF Signalling Pathway SHC1 SRF ELK1 EGFR MAPK8 STAT6 PLCG1 HRAS JAK1 MAPK3 MAP2K4 JUN MAP2K1 MAP3K1 CSNK2A1 EGF PRKCB STAT1 STAT2 STAT3 PRKCA FOS RASA1 GRB2 RAF1 SOS1 GNRH SIGNALING PATHWAY%PATHWHIZ%PW064816 GnRH Signaling Pathway CACNA1S MAP2K7 CGA PRKACA HRAS MAP2K3 MAP3K2 EGR1 JUN MAP2K1 MAP3K1 PRKCB FSHB MMP2 PLA2G4B CACNA2D2 PRKCA ACTN4 MAPK14 CACNB1 MMP14 LRRC7 GNAS GNRH1 GRB2 RAF1 SOS1 PLCB1 ATF4 HBEGF SRC CALML6 LHB CAMK2A ITPR1 CACNA1D ADCY1 CACNA1C CACNA1F PLD1 ELK1 EGFR CDC42 MAPK8 GNA11 GNRHR MAPK1 NF-KB SIGNALING PATHWAY%PATHWHIZ%PW064818 NF-kB Signaling Pathway TRADD TNF RELA CAMKK1 CAMKK2 IKBKB IRAK1 UBC RIPK1 FADD IKBKG MAP3K7 MAP3K1 CHUK IL1R1 NCOA3 TNFRSF1B NFKB1 TNFRSF1A NFKBIA IL1A TRAF6 TAB1 TLR4 MAP3K14 MYD88 COMPLEMENT PATHWAY%PATHWHIZ%PW064819 Complement Pathway C7 C9 SERPING1 MASP2 MASP1 CFB C1QC MBL2 CFD C1QB C1QA C1S C1R C4B_2 C8A C2 C3 C4A C5 C6 ALTERNATIVE COMPLEMENT PATHWAY%SMPDB%SMP0063815 Alternative Complement Pathway C8A CFB CFD C3 C5 C6 C7 C9 CFP UBIQUITIN–PROTEASOME PATHWAY%SMPDB%SMP0063816 Ubiquitin–Proteasome Pathway PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMD4 PSMB3 UBD UBC PSMB1 UBE2E1 PSMA5 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 UBA1 STUB1 LECTIN-INDUCED COMPLEMENT PATHWAY%SMPDB%SMP0063898 Lectin-Induced Complement Pathway C7 C9 MASP2 MASP1 C4B_2 C8A C2 MBL2 C3 C4A C5 C6 TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909 Toll-Like Receptor Pathway 1 MYD88 TLR2 LY96 ECSIT ELK1 RELA IKBKB MAPK8 IRAK1 CD14 IKBKG MAP3K7 MAP2K6 MAP2K3 MAP2K4 JUN MAP3K1 CHUK EIF2AK2 FOS MAPK14 NFKB1 TIRAP NFKBIA TOLLIP TRAF6 TLR9 TAB2 TLR7 TAB1 PPARA TLR4 TLR3 CLASSICAL COMPLEMENT PATHWAY%PATHWHIZ%PW065057 Classical Complement Pathway C1QB C1QA C1S C1R C4B_2 C8A C2 C3 C4A C5 C6 C7 C9 C1QC CXCR4 SIGNALING PATHWAY%SMPDB%SMP0064625 CXCR4 Signaling Pathway MAPK1 PTK2B PLCG1 RAF1 HRAS CRK BCAR1 MAPK3 MAP2K1 PXN CXCR4 PIK3C2G NFKB1 GNAI1 PTK2 NFKBIA GNGT1 CXCL12 GNAQ GNB1 D4-GDI SIGNALING PATHWAY%SMPDB%SMP0066935 D4-GDI Signaling Pathway JUN APAF1 PARP1 PRF1 GZMB ARHGAP5 CASP9 ARHGAP32 CASP8 CASP10 CASP3 ARHGDIB CASP1 CYCS T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977 T Cell Receptor Signaling Pathway PLCG1 RAC1 HRAS MAPK3 MAP2K4 JUN MAP2K1 MAP3K1 PRKCB NFATC3 NFATC2 NFATC1 PRKCA FOS VAV1 NFKB1 NFATC4 NFKBIA ZAP70 PIK3CA LCK CALM3 GRB2 CD247 PTPN7 RAF1 CALM1 SOS1 CALM2 LAT SHC1 TRAC CD3G PIK3R1 CD3E RASGRP1 CD3D ELK1 PIK3CG RELA PPP3CA PPP3CB MAPK8 PPP3CC TRBC1 UBC FYN STAT3 SIGNALING PATHWAY%PATHWHIZ%PW068597 Stat3 Signaling Pathway STAT3 MAPK1 TYK2 MTOR JAK1 TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593 Toll-Like Receptor Pathway 2 LY96 ECSIT RELA IKBKB MAPK8 IRAK1 CD14 IKBKG MAP3K7 MAP2K4 MAP3K1 CHUK MAPK14 NFKB1 TIRAP fliC NFKBIA TLR1 TOLLIP TRAF6 TLR9 TAB3 TLR8 TAB2 TLR7 TAB1 TLR6 TLR5 TLR4 TLR3 MYD88 TLR2 EPO SIGNALING PATHWAY%PATHWHIZ%PW070692 EPO Signaling Pathway HRAS MAPK3 STAT5A JUN MAP2K1 EPO SHC1 FOS ELK1 EPOR MAPK8 PTPN6 GRB2 PLCG1 JAK2 RAF1 SOS1 FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709 FAS signaling pathway ( CD95 ) RB1 PRKDC FAF1 FASLG LMNB2 LMNB1 MAPK8 CASP7 PAK1 CASP8 CASP6 CASP10 CASP3 LMNA ARHGDIB FADD MAP3K7 PAK2 SPTAN1 DFFB MAP2K4 DFFA JUN DAXX MAP3K1 PARP1 RIPK2 CFLAR PTPN13 FAS BCR SIGNALING PATHWAY%PATHWHIZ%PW070885 BCR Signaling Pathway RAF1 CALM1 SOS1 CALM2 SHC1 ELK1 CD79B CD79A PPP3CA PPP3CB MAPK8 PPP3CC BLNK PLCG1 RAC1 HRAS MAPK3 LYN JUN MAP2K1 MAP3K1 SYK PRKCB NFATC3 NFATC2 NFATC1 PRKCA FOS VAV1 NFATC4 BTK ORAI1 CALM3 GRB2 CARDIOLIPIN BIOSYNTHESIS (BARTH SYNDROME)%SMPDB%SMP0074684 Cardiolipin Biosynthesis (Barth Syndrome) PGS1 AGPAT5 GPAM PTPMT1 GPD1 CRLS1 CDS2 SUCCINATE SIGNALLING%PATHWHIZ%PW084312 Succinate Signalling IL1B P4HA3 NLRP3 TLR4 HIF1A SIRT3 NAD+ SIGNALLING PATHWAY (CANCER)%PATHWHIZ%PW084315 NAD+ Signalling Pathway (Cancer) NMNAT2 TP53 SIRT1 NADK NQO1 NMNAT1 AIFM2 NAMPT CD38 NMNAT3 NAD+ SIGNALLING AND AGING%SMPDB%SMP0084271 NAD+ Signalling and Aging NMNAT3 NMNAT2 CLOCK SIRT1 PPARGC1A NADK NQO1 NMNAT1 NPR1 NAMPT RORA SUCCINATE SIGNALLING DURING INFLAMMATION%SMPDB%SMP0084634 Succinate Signalling During Inflammation SUCNR1 CHUK NOS3 PRKCA NFKB1 PTGS1 IKBKB MAPK11 CREB1 MAPK1 IKBKG PLCB1 MAPK3 BILE ACID DIRECT SIGNALLING PATHWAY (1)%PATHWHIZ%PW087627 Bile Acid Direct Signalling Pathway (1) ABCC4 SLC10A2 SLCO1A2 NR1H4 GPBAR1 BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851 Bile Acid Indirect Signalling Pathway KLB FGF19 SLC10A2 NR1H4 FGFR4 FGFR3 FGFR2 FGFR1 WARBURG EFFECT%SMPDB%SMP0086930 Warburg Effect Slc2a13 Fh Mdh1 Slc16a1 Idh1 Cad Gsr Idh3a Pgd Hk1 Bckdhb Pkm Ireb2 Aco1 Pdhx Gpi H6pd Glud1 Taldo1 Eno1 Gapdhs Sdhd Aldoc Bpgm Sdhc Sdhb Sdha Gls Rpia Acly Tktl1 Cs Idh3g Mpc1 Ogdh Pgk2 Pfkm Sucla2 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087197 Fructose and Mannose Degradation PHPT1 FBP1 PFKFB1 TPI1 TGDS MPI PMM2 SORD AKR1B1 KHK HK1 GMPPB PFKL FCSK FPGT ALDOB GFUS GLYCOLYSIS%PATHWHIZ%PW088241 Glycolysis GPI TPI1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK1 PKM GALM ALDOB PFKM GAPDH GLUCONEOGENESIS%PATHWHIZ%PW088242 Gluconeogenesis MPC1 GALM ALDOB PCK1 FBP1 GAPDH SLC25A11 PGM1 GPI PANK3 TPI1 MDH2 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK1 PC INOSITOL METABOLISM%PATHWHIZ%PW088261 Inositol Metabolism AMBRA1 INPP4A MINPP1 SYNJ1 PIK3CA IMPA1 PTPMT1 ITPKA PI4KA PLCD1 IPPK CCT3 VAC14 MIOX BECN1 ISYNA1 INPP1 SACM1L IPMK ITPK1 PIK3R4 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088265 Pentose Phosphate Pathway PRPS1 GPI G6PD RPE TALDO1 DERA RPIA PFKL PGLS ALDOB TKT FBP1 RBKS PGM1 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088271 Starch and Sucrose Metabolism GPI AGL GAA PYGL PGM2L1 HK1 GYS1 UGDH UGP2 LOC539383 UGT3A1 GUSB PGM1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088275 Inositol Phosphate Metabolism IPPK ISYNA1 INPP1 IPMK ITPK1 NUDT3 INPP4A INPP4B MINPP1 PPIP5K1 SYNJ1 IMPA1 ITPKA IP6K1 WARBURG EFFECT%SMPDB%SMP0087270 Warburg Effect PGAM2 TALDO1 SDHC SDHD PGD SDHA SDHB CS RPIA GLUD1 PFKL PKM PC OGDH SUCLG2 ACO1 SUCLG1 ACO2 ALDOB TKT DLD GAPDH GPI FH GLS2 SLC2A2 DLST SLC1A5 ENO1 PDHB HK1 MPC1 IDH3B PGK1 PGLS IDH3A PDHX G6PD PDHA1 SLC16A1 MDH1 IDH3G IDH1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087296 Fructose and Mannose Degradation Fbp1 Gmppa Tpi1 Pmm1 Mpi Sord Uxs1 Aldob Aldoa Hk1 Khk Pfkl Pfkfb1 Fcsk Gmds Akr1b1 GLYCOLYSIS%PATHWHIZ%PW088336 Glycolysis Gpi Tpi1 Pklr Eno1 Gapdh G6pc1 Aldoa Hk2 Pgam2 Slc2a2 Pgam1 Galm Pfkm GLUCONEOGENESIS%SMPDB%SMP0087318 Gluconeogenesis Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 INOSITOL METABOLISM%PATHWHIZ%PW088354 Inositol Metabolism Itpk1 Isyna1 Vac14 Becn1 Sacm1l Ambra1 Minpp1 Pik3r4 Itpka Ippk Cct3 Miox Ptpmt1 Inpp4a Ipmk Impa1 Bpnt1 Pik3c3 Plcd1 Inpp5j PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088358 Pentose Phosphate Pathway Gpi Taldo1 Aldoa Rpia Dera Prps1 Pfkl G6pdx Pgls Tkt Fbp1 Rbks Pgm1 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088364 Starch and Sucrose Metabolism Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088368 Inositol Phosphate Metabolism Itpka Ippk Inpp4a Inpp4b Ipmk Impa1 Bpnt1 Ip6k1 Inpp5j Itpk1 Isyna1 Ppip5k1 Nudt3 Minpp1 WARBURG EFFECT%PATHWHIZ%PW088382 Warburg Effect Suclg2 Pgam2 Slc2a2 Pgk1 Slc1a3 Fh Mdh1 Slc16a1 Idh1 Idh3a Dlst Pdhb Pgd Gapdh Hk2 Pkm Aco2 Pgls Dlat Aco1 Tkt Dld Gpi Pklr Glud1 Taldo1 Aldob Eno1 Sdhd Sdhc Sdhb Sdha Gls Idh3B Rpia Cs Dhtkd1 Pdha1 Pfkl Idh3g Suclg1 Mpc1 G6pdx NUCLEOTIDE SUGARS METABOLISM%SMPDB%SMP0087384 Nucleotide Sugars Metabolism Uxs Gale Galt Hex-T Galk sgl Pgm1 Ugp GLYCOLYSIS%SMPDB%SMP0087391 Glycolysis Galm2 Pyk Hex-T Gapdh1 Eno Aldo Tpi Pgi Pfk Glut1 CG15400 Pgam2 Pgam1 INOSITOL METABOLISM%SMPDB%SMP0087396 Inositol Metabolism INPP5E mTor CG1846 Dmel\CG9391 IP3K2 Mipp1 Sac1 Atg6 norpA Miox fab1 Pi4KIIIalpha Ipp Pi3K92E Inos Ipk2 Vps15 Ipk1 Dmel\CG5608 PTPMT1 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0087400 Pentose Phosphate Pathway G6pd Prps Rpe Taldo Aldo Rpi Dmel\CG13369 Dera Pgi Pfk Fbp Pgls Tkt Pgm1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088427 Inositol Phosphate Metabolism CG1846 Dmel\CG9391 IP3K2 Inos Mipp1 Ipk2 Ip6k Ipk1 Aps l(1)G0196 INPP5E Ipp WARBURG EFFECT%SMPDB%SMP0087420 Warburg Effect Idh3a ScsbetaG Dlst SdhD Pdhb SdhC SdhB Pgd SdhA Pcb Fum1 Pgi Pgk Pgls Dlat Tkt Irp-1A Dld Gapdh1 Eno Taldo Aldo Rpi Gdh Scsalpha1 Idh Gls Pdha1 Oadh Pfk Mpc1 Glut1 Mct1 Pgam2 Eaat1 Cs1 G6pd Pyk Hex-T Mdh1 mAcon2 GLYCOLYSIS%PATHWHIZ%PW088465 Glycolysis pfk-1.1 gpd-3 hxk-1 fdgt-1 enol-1 pyk-1 C01B4.6 tpi-1 gpi-1 aldo-1 INOSITOL METABOLISM%PATHWHIZ%PW088478 Inositol Metabolism ttx-7 cct-3 inos-1 ipmk-1 vps-15 age-1 unc-26 gpap-1 CELE_F28C6.8 egl-8 ippk-1 vps-34 bec-1 lfe-2 vacl-14 C54E4.5 inpp-4b SPHINGOLIPID METABOLISM%PATHWHIZ%PW088482 Sphingolipid Metabolism spl-1 C29E4.10 gana-1 sphk-1 sul-2 sptl-1 F53B1.2 plpp-1.2 bre-4 dhs-3 W02F12.2 sptl-2 ugt-58 cerk-1 ttm-5 enpp-1 gba-3 cgt-3 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088490 Pentose Phosphate Pathway pgm-1 CELE_F08F8.7 F09E5.3 gspd-1 Y57G11C.3 prps-1 tald-1 fbp-1 tkt-1 rpia-1 CELE_F07A11.5 gpi-1 aldo-1 pfk-1.1 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0087496 Inositol Phosphate Metabolism gpap-1 inpp-4b ttx-7 CELE_Y92H12BL.5 F46F11.1 ippk-1 lfe-2 inos-1 ipmk-1 CELE_F30A10.3 unc-26 WARBURG EFFECT%SMPDB%SMP0087527 Warburg Effect mev-1 Y57G11C.3 cts-1 mpc-1 enol-1 tald-1 dld-1 sucl-1 aco-1 fum-1 sucg-1 aco-2 mdh-1 pyc-1 aldo-1 T25B9.9 sdhb-1 pdha-1 sdha-1 pdhb-1 pyk-1 ogdh-2 gspd-1 glt-1 hxk-1 fdgt-1 tkt-1 glna-2 gdh-1 rpia-1 dlat-1 gpi-1 pfk-1.1 sdhd-1 gpd-3 pgk-1 idha-1 idh-1 idhb-1 mct-6 BILE ACID DIRECT SIGNALLING PATHWAY (2)%PATHWHIZ%PW090771 Bile Acid Direct Signalling Pathway (2) GLP1R SLC10A2 GPBAR1 CD40L SIGNALLING PATHWAY%SMPDB%SMP0089759 CD40L Signalling Pathway CD40 MAP3K1 CHUK DUSP1 ELP1 TNFAIP3 MAPK14 NFKB1 IKBKB NFKBIA CD40LG TRAF3 TRAF6 IKBKG G-PROTEIN SIGNALING THROUGH TUBBY PROTEINS%PATHWHIZ%PW090863 G-Protein Signaling Through Tubby Proteins TUB GNGT1 CHRM1 GNAQ GNB1 HTR2C PLCB1 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW090995 g-Secretase Mediated ErbB4 Signalling Pathway ADAM17 ERBB3 ERBB4 PRKCA NRG2 PSEN1 EGFR ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway PRKCB P2RY2 PTK2B PRKCA PLCG1 CIRCADIAN RHYTHMS%SMPDB%SMP0090831 Circadian Rhythms PER1 NPR1 CRY1 CSNK1E CLOCK HOP PATHWAY IN CARDIAC DEVELOPMENT%SMPDB%SMP0090879 Hop Pathway in Cardiac Development SRF GATA4 NKX2-5 HOPX LPS AND CITRATE SIGNALING AND INFLAMMATION%PATHWHIZ%PW101069 LPS and Citrate Signaling and Inflammation TIRAP RELA ACACA IKBKB CS NFKBIA ACLY TRAF6 ME1 PFK1 CD14 IKBKG TLR4 MYD88 SLC25A1 CHUK MDH1 LY96 SDHC SDHD SDHA SDHB NFKB1 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW101384 Protein Synthesis: Alanine RPL26 RPL29 RPL28 UBA52 AARS1 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%SMPDB%SMP0108012 Activation of PKC Through G Protein-Coupled Receptor Gnaq Prkca Plcb1 Itpr1 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells IGHE Grb2 Prkca Raf1 Csf2 Pik3r1 Lat Hras Inpp5d Mapk8 Il13 Mapk1 Map2k7 Tnf Fcer1a Il4 Il5 Akt1 Kras Fyn Rac1 Pdk1 Lyn Mapk14 Syk Plcg1 Gab2 Ms4a2 Vav1 Rasgrf1 Map2k2 Nras Map2k1 Lck Fcer1g Blnk NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0108236 Nitric Oxide Signaling Pathway Grin2a Ppp3ca Dlg4 Calm3 Nos1 Prkca Prkacb Grin1 PHOSPHOLIPASE C SIGNALING PATHWAY%PATHWHIZ%PW109280 Phospholipase C Signaling Pathway Plcg1 Akt1 Pik3r6 Prkca Vav1 Plcb1 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%PATHWHIZ%PW109282 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Prkca Raf1 Nfkbia Hras Rela Mapk3 Plcb1 Itpr1 Map2k1 Prkcb Mapk1 Nfkb1 PROTEIN SYNTHESIS: ARGININE%SMPDB%SMP0111853 Protein Synthesis: Arginine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RARS1 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: ASPARAGINE%SMPDB%SMP0111854 Protein Synthesis: Asparagine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 NARS1 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: ASPARTIC ACID%SMPDB%SMP0111858 Protein Synthesis: Aspartic Acid RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 DARS1 RPL37A RPL24 PROTEIN SYNTHESIS: CYSTEINE%PATHWHIZ%PW112918 Protein Synthesis: Cysteine RPL26 RPL29 CARS1 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: GLUTAMINE%SMPDB%SMP0111862 Protein Synthesis: Glutamine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 QARS1 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: GLUTAMIC ACID%PATHWHIZ%PW112922 Protein Synthesis: Glutamic Acid RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 EPRS1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: GLYCINE%PATHWHIZ%PW112928 Protein Synthesis: Glycine RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 GARS1 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: HISTIDINE%PATHWHIZ%PW112929 Protein Synthesis: Histidine RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 HARS1 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: ISOLEUCINE%SMPDB%SMP0111872 Protein Synthesis: Isoleucine RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 IARS1 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: LEUCINE%SMPDB%SMP0111873 Protein Synthesis: Leucine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 LARS1 RPL37A RPL24 PROTEIN SYNTHESIS: LYSINE%SMPDB%SMP0111874 Protein Synthesis: Lysine RPL26 RPL29 RPL28 UBA52 RPL10 KARS1 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: METHIONINE%PATHWHIZ%PW112933 Protein Synthesis: Methionine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 MARS1 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: PHENYLALANINE%PATHWHIZ%PW112934 Protein Synthesis: Phenylalanine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU FARSA RPS21 RPS24 RPS23 FARSB RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: PROLINE%PATHWHIZ%PW113695 Protein Synthesis: Proline RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 EPRS1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: SERINE%PATHWHIZ%PW120517 Protein Synthesis: Serine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 SARS1 RPL37A RPL24 PROTEIN SYNTHESIS: THREONINE%PATHWHIZ%PW120525 Protein Synthesis: Threonine RPL26 RPL29 TARS1 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: TRYPTOPHAN%PATHWHIZ%PW120526 Protein Synthesis: Tryptophan RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A WARS1 RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: TYROSINE%PATHWHIZ%PW120527 Protein Synthesis: Tyrosine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 YARS1 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: VALINE%PATHWHIZ%PW120528 Protein Synthesis: Valine RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 VARS1 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW120529 Protein Synthesis: Alanine Rplp1 Rpl23 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rpl12 Rps3 Rps2 Rpl10a Rpl7a Rps25 Rps4x Rps26 Rps27 Rps28 Rps29 Rpl27a Rps20 Rps21 Rps23 Rps24 Rpl41 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl5 Rps15 Rps16 Rpl3 Rps17 Rps15a Rps18 Rps19 Rpl35 Rpl36 Rpsa Rpl37 Rpl38 Rpl39 Rpl8 Rps10 Rpl9 Rps11 Rpl6 Rps12 Rpl7 Rps13 Aars1 Rpl30 Rpl31 Rpl32 Rpl34 Rpl36a Rps3a Rps9 Rps7 Rps8 Rpl37a Rps5 Rps6 Rplp2 Rpl24 Rpl26 Uba52 Rpl27 Rack1 Rpl28 Rpl29 Rpl21 Rplp0 Rpl22 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0120583 Glucose-6-phosphate Dehydrogenase Deficiency Gpi H6pd Rpe Prpsap1 Taldo1 Aldob Pgd Rpia Dera Tktl1 Pfkm Rbks Fbp2 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0120584 Ribose-5-phosphate Isomerase Deficiency Gpi H6pd Rpe Prpsap1 Taldo1 Aldob Pgd Rpia Dera Tktl1 Pfkm Rbks Fbp2 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120585 Transaldolase Deficiency Gpi H6pd Rpe Prpsap1 Taldo1 Aldob Pgd Rpia Dera Tktl1 Pfkm Rbks Fbp2 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120596 Glycogenosis, Type VII. Tarui Disease Slc2a13 Gpi Tpi1 Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pkm Pgam1 Galm Pgk2 Pfkp GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW121872 Glycogen Synthetase Deficiency Gpi Ugt8 Gusb Hk1 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%SMPDB%SMP0120617 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Gpi Ugt8 Gusb Hk1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120618 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Gpi Ugt8 Gusb Hk1 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120619 Glycogenosis, Type VI. Hers Disease Gpi Ugt8 Gusb Hk1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%PATHWHIZ%PW121876 Mucopolysaccharidosis VII. Sly Syndrome Gpi Ugt8 Gusb Hk1 SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW121877 Sucrase-Isomaltase Deficiency Gpi Ugt8 Gusb Hk1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%PATHWHIZ%PW121880 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 FRUCTOSURIA%PATHWHIZ%PW121881 Fructosuria Tpi1 Aldob Aldoc Pfkm Hk1 Fbp2 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW121882 Fructose-1,6-diphosphatase Deficiency Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW121883 Triosephosphate Isomerase Deficiency Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW121892 Fanconi-Bickel Syndrome Slc2a13 Gpi Tpi1 Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pkm Pgam1 Galm Pgk2 Pfkp GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW121893 Glycogenosis, Type IB Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW121894 Glycogenosis, Type IC Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%PATHWHIZ%PW121901 Glycogenosis, Type IA. Von Gierke Disease Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW121913 Fructose Intolerance, Hereditary Tpi1 Aldob Aldoc Pfkm Hk1 Fbp2 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%PATHWHIZ%PW121967 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW122063 Glucose-6-phosphate Dehydrogenase Deficiency Gpi Taldo1 Aldoa Rpia Dera Prps1 Pfkl G6pdx Pgls Tkt Fbp1 Rbks Pgm1 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122064 Ribose-5-phosphate Isomerase Deficiency Gpi Taldo1 Aldoa Rpia Dera Prps1 Pfkl G6pdx Pgls Tkt Fbp1 Rbks Pgm1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120804 Transaldolase Deficiency Gpi Taldo1 Aldoa Rpia Dera Prps1 Pfkl G6pdx Pgls Tkt Fbp1 Rbks Pgm1 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120815 Glycogenosis, Type VII. Tarui Disease Gpi Tpi1 Pklr Eno1 Gapdh G6pc1 Aldoa Hk2 Pgam2 Slc2a2 Pgam1 Galm Pfkm GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW122096 Glycogen Synthetase Deficiency Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW122097 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120837 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120838 Glycogenosis, Type VI. Hers Disease Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0120839 Mucopolysaccharidosis VII. Sly Syndrome Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW122101 Sucrase-Isomaltase Deficiency Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0120843 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 FRUCTOSURIA%PATHWHIZ%PW122105 Fructosuria Fbp1 Gmppa Tpi1 Pmm1 Mpi Sord Uxs1 Aldob Aldoa Hk1 Khk Pfkl Pfkfb1 Fcsk Gmds Akr1b1 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW122106 Fructose-1,6-diphosphatase Deficiency Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122107 Triosephosphate Isomerase Deficiency Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW122116 Fanconi-Bickel Syndrome Gpi Tpi1 Pklr Eno1 Gapdh G6pc1 Aldoa Hk2 Pgam2 Slc2a2 Pgam1 Galm Pfkm GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW122117 Glycogenosis, Type IB Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW122118 Glycogenosis, Type IC Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0120864 Glycogenosis, Type IA. Von Gierke Disease Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 FRUCTOSE INTOLERANCE, HEREDITARY%SMPDB%SMP0120876 Fructose Intolerance, Hereditary Fbp1 Gmppa Tpi1 Pmm1 Mpi Sord Uxs1 Aldob Aldoa Hk1 Khk Pfkl Pfkfb1 Fcsk Gmds Akr1b1 SUCCINATE SIGNALLING DURING INFLAMMATION%PATHWHIZ%PW122149 Succinate Signalling During Inflammation Nfkb1 Ikbkg Prkca Ptgs1 Mapk3 Plcb1 Creb1 Ikbkb Mapk14 Nos3 Mapk1 GROWTH HORMONE SIGNALING PATHWAY%SMPDB%SMP0120947 Growth Hormone Signaling Pathway Ghr Gh1 Stat5a Stat5b Map2k1 Rps6ka1 Slc2a4 Grb2 Prkca Raf1 Jak2 Hras Socs1 Shc1 Irs1 Ins2 Insr Plcg1 Mapk1 Ptpn6 Mapk3 Rasgrf1 EGF SIGNALLING PATHWAY%SMPDB%SMP0120948 EGF Signalling Pathway Fos Csnk2a1 Elk1 Map2k7 Mapk3 Rasgrf1 Stat5a Map3k1 Map2k1 Prkcb Stat3 Grb2 Prkca Raf1 Jak2 Hras Jun Mapk8 Shc1 Rasa1 Egf Srf Erbb4 Plcg1 GNRH SIGNALING PATHWAY%SMPDB%SMP0120949 GnRH Signaling Pathway Prkaca Rasgrf1 Map3k1 Map2k1 Prkcb Grb2 Actn4 Prkca Raf1 Hras Atf4 Itpr1 Gna11 Mapk8 Src Fshb Erbb4 Lhb Gnrh1 Mapk1 Calm3 Gnrhr Pla2g4a Elk1 Pld1 Map2k7 Hbegf Plcb1 Camk2a Cga Adcy5 Cdc42 Egr1 Jun Mapk14 Mmp14 Lrrc7 Mmp2 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0120959 T Cell Receptor Signaling Pathway Nfat5 Map3k1 Map2k1 Prkcb Lck Rasgrp1 Grb2 Prkca Raf1 Pik3r1 Lat Hras Mapk8 Shc1 Ptpn7 Calm3 Cd247 Cd3g Elk1 Cd3e Cd3d Map2k7 Mapk3 Ubc Nfkb1 Fyn Rac1 Ppp3ca Jun Ppp3cb Syk Plcg1 Fos Nfkbia Vav1 Rela Rasgrf1 BCR SIGNALING PATHWAY%SMPDB%SMP0120964 BCR Signaling Pathway Cd79a Cd79b Mapk8 Shc1 Calm3 Elk1 Mapk3 Rac1 Lyn Ppp3ca Jun Ppp3cb Syk Plcg1 Orai1 Fos Vav1 Rasgrf1 Nfat5 Map3k1 Map2k1 Prkcb Lck Blnk Grb2 Prkca Raf1 Hras G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW122231 g-Secretase Mediated ErbB4 Signalling Pathway Erbb4 Erbb3 Psen1 Nrg2 Prkca Adam17 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway Prkcb P2ry2 Plcg1 Ptk2b Prkca KIDNEY FUNCTION- PROXIMAL CONVOLUTED TUBULE%SMPDB%SMP0121001 Kidney Function- Proximal Convoluted Tubule SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 SLC4A4 SLC9A1 AQP1 SLC7A5 CA1 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SLC38A4 KIDNEY FUNCTION - DESCENDING LIMB OF THE LOOP OF HENLE%SMPDB%SMP0121009 Kidney Function - Descending Limb of the Loop of Henle AQP1 KIDNEY FUNCTION - ASCENDING LIMB OF THE LOOP OF HENLE%PATHWHIZ%PW122277 Kidney Function - Ascending Limb of The Loop of Henle SLC12A1 ATP1A4 ATP1B4 ATP1A3 CLCNKA ATP1A2 ATP1B3 ATP1A1 ATP1B2 ATP1B1 FXYD2 REN SLC12A6 KIDNEY FUNCTION - COLLECTING DUCT%PATHWHIZ%PW122278 Kidney Function - Collecting Duct SCNN1G CA1 SCNN1D SCNN1B FXYD2 SCNN1A REN ATP6V1B1 SLC14A2 ATP1A4 ATP1B4 ATP1A3 SLC4A1 ATP1A2 ATP1B3 ATP1A1 ATP1B2 ATP1B1 AQP2 AQP3 KIDNEY FUNCTION - DISTAL CONVOLUTED TUBULE%SMPDB%SMP0121012 Kidney Function - Distal Convoluted Tubule ATP4A FXYD2 TRPV5 REN SLC12A3 ATP1A4 ATP1B4 ATP1A3 CLCNKA ATP1A2 ATP1B3 ATP1A1 ATP1B2 ATP1B1 AQP2 AQP3 SLC8A1 ATP4B PANCREAS FUNCTION - BETA CELL%PATHWHIZ%PW122285 Pancreas Function - Beta Cell GNG2 GNAQ GNB1 PLCB1 VAMP2 RAPGEF4 GLP1R CHRM3 RAB3A ABCC8 CACNA1A SLC2A2 CACNA2D2 PRKCA ITPR3 CAMKK1 CACNB1 RIMS2 ADCY10 PANCREAS FUNCTION - ALPHA CELL%PATHWHIZ%PW122296 Pancreas Function - Alpha Cell SCN5A SNTB1 SNTA1 SNTB2 CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 GCG MEVALONATE PATHWAY%SMPDB%SMP0121055 Mevalonate Pathway PMVK MVD HMGCR LSS ACAT1 FDFT1 FDPS IDI1 SQLE MVK HMGCS1 BLOCH PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121057 Bloch Pathway (Cholesterol Biosynthesis) HSD17B7 LBR EBP NSDHL CYP51A1 SC5D DHCR24 MSMO1 DHCR7 KANDUTSCH-RUSSELL PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis) HSD17B7 LBR EBP NSDHL CYP51A1 SC5D DHCR24 MSMO1 DHCR7 ARSENATE DETOXIFICATION%PATHWHIZ%PW122396 Arsenate Detoxification AS3MT PNP GSTO1 AQP9 SLC2A1 AQP7 SLC2A4 EUMELANIN BIOSYNTHESIS%SMPDB%SMP0121124 Eumelanin Biosynthesis DCT TYR ALDOSTERONE FROM STEROIDOGENESIS%SMPDB%SMP0121126 Aldosterone from Steroidogenesis GNG2 CYP11A1 CYP21A2 CYP11B2 GNAQ HSD3B1 GNB1 AGTR1 PANCREAS FUNCTION - DELTA CELL%PATHWHIZ%PW122406 Pancreas Function - Delta Cell CACNB1 SST ABCC8 CACNA1A SLC2A2 CACNA2D2 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION%SMPDB%SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation DLST ALDH8A1 DLD ACMSD DHTKD1 FRUCTOSE METABOLISM%PATHWHIZ%PW122616 Fructose Metabolism tpiA pgk eno ppsA GLYCEROL METABOLISM%SMPDB%SMP0121309 Glycerol Metabolism tpiA pgi pgk fbp eno ppsA GLYCEROL METABOLISM II%PATHWHIZ%PW122618 Glycerol Metabolism II tpiA pgi pgk fbp eno ppsA GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW122619 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) tpiA pgi pgk fbp eno ppsA GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%SMPDB%SMP0121312 Glycerol Metabolism IV (Glycerophosphoglycerol) tpiA pgi pgk fbp eno ppsA GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%SMPDB%SMP0121313 Glycerol Metabolism V (Glycerophosphoserine) tpiA pgi pgk fbp eno ppsA TUMOR SUPPRESSOR ACTIVITY OF SMARCB1%WIKIPATHWAYS_20260510%WP4204%HOMO SAPIENS Tumor suppressor activity of SMARCB1 DPF3 SMARCE1 SUZ12 SMARCC1 SMARCC2 H3F3B ACTL6B EED CDKN2A PTCH1 ACTL6A ARID1A ARID1B SMARCA4 CDK6 SMO CDK4 EZH2 RB1 SMARCD1 SMARCD2 SMARCD3 GLI3 GLI4 RBBP4 DPF1 DPF2 MAPK AND NFKB SIGNALING INHIBITED BY YERSINIA YOPJ%WIKIPATHWAYS_20260510%WP3849%HOMO SAPIENS MAPK and NFkB signaling inhibited by Yersinia YopJ IKBKB NFKBIA MAP3K1 CHUK RRAS TRAF6 MAPK1 IKBKG RAF1 MAP3K14 NFKB1 MAP2K6 CALCIUM REGULATION IN CARDIAC CELLS%WIKIPATHWAYS_20260510%WP536%HOMO SAPIENS Calcium regulation in cardiac cells CHRM2 CHRM3 HEL2 CHRM1 CHRM4 CHRM5 SLC8A1 RGS4 RGS5 RGS2 GJA1 GJA3 RGS1 GJA5 GJA4 GJA9 GJA8 RGS6 RGS7 PRKCH PRKCB PRKCE PRKCA ATP1B3 ATP1B2 ATP1B1 CACNB1 CACNB3 ADCY9 PRKAR1B STIM2 PRKAR1A ORAI1 PRKCQ PRKD1 GNAZ CACNA1B CACNA1A ITPR2 ADRB1 CACNA1C ADRB2 PRKCZ GJC1 GRK5 GRK4 SFN CACNA1S GNG12 GNG11 GNG13 GNAO1 PKIB GJB2 GJB1 GJB4 GJB3 PKIA GJB6 GNB2 FXYD2 GNB1 GNAS GNB4 GNB3 GNB5 PKIG CALM1 RYR1 RYR2 ATP2A2 ADRA1D ARRB2 ADRA1B ADRA1A RYR3 GNGT1 YWHAQ ANXA6 HEL-S-1 YWHAG YWHAZ GJD2 PLCB3 ADRB3 CASQ2 CASQ1 RGS18 RGS17 CAMK2D RGS14 RGS16 CAMK2A ATP1A4 GNAI3 ADCY3 ADCY1 ADCY8 HEL-S-99n GNAI1 ADCY6 GNG3 PLN GNG2 GNG5 GNG4 GNG7 GNA11 RGS20 GNG8 CAMK2G KCNJ3 KCNJ5 KCNB1 ATP2B3 CXNO ATP2B2 ATP2B1 FKBP1A CAMK4 CXNA RGS10 CAMK1 RGS11 SARS COV 2 MITOCHONDRIAL CHRONIC OXIDATIVE STRESS AND ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260510%WP5183%HOMO SAPIENS SARS CoV 2 mitochondrial chronic oxidative stress and endothelial dysfunction MITA TERF2 TNF ACE2 MAVS IL6 TRAF3 RPS6KA1 NDUFAF2 NLRP3 TERF2IP REN NDUFAF1 TRAF6 TOMM70 NLRX1 ACAD9 NFKB1 IL18 SIRT6 ECSIT ETHYLMALONIC ENCEPHALOPATHY%WIKIPATHWAYS_20260510%WP5030%HOMO SAPIENS Ethylmalonic encephalopathy ETHE1 SUOX CORTICOTROPIN RELEASING HORMONE SIGNALING%WIKIPATHWAYS_20260510%WP2355%HOMO SAPIENS Corticotropin releasing hormone signaling CREB1 CYP21A2 GNAZ CRH TLR4 IVL PRKAA2 RELA CACNA1H CRHR1 ACACA CRHR2 MAPK9 MAPK8 CYP11A1 PLCG2 PLCG1 MAPK3 TFAP2A GNAO1 TGFB1 JUND JUP HSD3B2 HSD3B1 BRAF MAPK14 IL2 GNB2 FOSL2 POMC GNB1 FOSL1 GNAS ARHA STAR GNB3 SP1 GNB5 KRT14 BCL2 CTNNB1 FOSB TCF4 ARRB2 CAMK2A GNAI1 GNA11 NFKBIA MAPK1 RAF1 NFKB1 IL18 GJA1 GSK3B CXCL8 ECE1 CASP9 PRKCB CRHBP CASP12 PRKCA TRIM28 CASP3 JUNB MAP3K5 SULT2A1 PRKCI MAP2K1 PARP1 KRT1 FOS ERN1 PRKCQ HEMOGLOBIN SWITCHING EMBRYONIC FETAL AND ADULT%WIKIPATHWAYS_20260510%WP5605%HOMO SAPIENS Hemoglobin switching embryonic fetal and adult HBZ tal-1 HBG2 LDB1 HBG1 LMO2 HBE1 HBB HBA2 HBD GATA1 ESTROGEN SIGNALING%WIKIPATHWAYS_20260510%WP712%HOMO SAPIENS Estrogen signaling CREB1 BCL2 GNGT1 MAPK9 JUN PIK3CA IKBKB GPER CHUK BRAF MAPK14 MAPK1 IKBKG MAP2K1 GNB1 NFKB1 GNAS FOS SP1 GENES RELATED TO PRIMARY CILIUM DEVELOPMENT BASED ON CRISPR %WIKIPATHWAYS_20260510%WP4536%HOMO SAPIENS Genes related to primary cilium development based on CRISPR TMEM231 IFT20 TTC8 TMEM17 SASS6 MKS1 IFT27 CEP162 B9D1 CIBAR1 DNCL1 CLUAP1 CEP44 IFT25 DYNC2I2 TTC23 C2CD3 TRAF3IP1 CEP19 IFT172 CBY1 EFCAB7 TXNDC15 IFT52 TCTN3 TCTN2 TMEM107 TCTN1 CDK20 TRAPPC11 BBS9 BBS7 KIFAP3 CEP97 IFT57 CC2D2A IFT56 BBS5 BBS4 DYNC2H1 OFD1 DYNLT1 IFT140 CEP295 ARMC9 IFT80 RPGRIP1L WDR35 LZTFL1 BBS10 IFT43 EVC BBS12 IFT81 TMEM216 CCDC41 WDPCP CEP20 IFT46 TEDC1 CEP104 IFT70B TEDC2 ARL6 ARL3 FBF1 DYNLT2B KATNB1 TUBD1 DYNC2LI1 IFT74 ARL13B KIF3B KIF3A TMEM67 RAB23 INPP5E KIAA0753 CEP192 CEP76 PIBF1 EVC2 BBS2 BBS1 SCLT1 RABL2B CPLANE1 TUBE1 FUZ CPLANE2 MIB1 HALLMARK OF CANCER SUSTAINING PROLIFERATIVE SIGNALING%WIKIPATHWAYS_20260510%WP5475%HOMO SAPIENS Hallmark of cancer sustaining proliferative signaling RELA CDKN1A FLT1 FLT3 MAPK3 FLT4 PTEN PIK3CD NR1C2 JUP IGF1R RPTOR DEPTOR BRAF CCND1 SALL4 MYC AKT3 KDR MLST8 HRAS IL6R PDGFRA MAP2K2 KSR1 CTNNB1 TSC2 TSC1 AXIN2 TTI1 GAREM2 PYGO1 AKT1S1 KIT RARA ULK2 SOS1 SOS2 MET EPHA2 JUN PIK3CA CSF1R SHC1 SRC LEF1 LRP5 RETN EGFR FOXO1 LRP6 WNT1 RUNX1T1 NTRK1 NGFR NTRK2 CSNK1A1 ZBTB16 INSR STAT3 PML MTOR BCL9 APC RHEB REL MDM2 KRAS GRB2 TCF3 FGFR4 NFKBIE FGFR3 FGFR2 FGFR1 IKBKB NFKBIA CHUK MAPK1 IKBKG RAF1 NFKB1 IL6 GSK3B MAP2K1 FOS SICKLE CELL DISEASE%WIKIPATHWAYS_20260510%WP5604%HOMO SAPIENS Sickle cell disease IL1B TLR4 HBB IL18 HBA2 MELANOMA%WIKIPATHWAYS_20260510%WP4685%HOMO SAPIENS Melanoma CDKN1A MAPK3 PTEN PIK3CD BRAF CCND1 AKT3 KDR ARHA HRAS MAP2K2 CALM1 KIT SOS1 SOS2 PIK3CA RB1 CDKN2A MDM2 KRAS GRB2 CDK6 CDK4 CALML6 ARAF HEL114 CALML3 CALML4 GRM3 MAPK1 PREX2 RAC1 RAF1 POLK EXOC7 RHOB DDB2 PDE5A SHC2 PIK3R3 PIK3R2 PIK3R1 NRAS PAK1 ERBB4 E2F2 E2F3 BAK1 GADD45B BAD GADD45A PTPN11 GADD45G NF1 BAX MAP2K1 MIRNAS INVOLVED IN DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260510%WP1545%HOMO SAPIENS miRNAs involved in DNA damage response CREB1 H2AX RAD52 CCND3 CDKN1B CCNE1 ATM CCND1 MYC CDKN1A CDK6 CELL CYCLE%WIKIPATHWAYS_20260510%WP179%HOMO SAPIENS Cell cycle CDC27 CHEK1 EP300 SKP2 SKP1 ANAPC7 CDC25B RBX1 CCNE2 ANAPC5 MAD1L1 ANAPC1 ANAPC2 ANAPC13 PRKDC PKMYT1 ANAPC10 ANAPC11 CCNB3 TGFB1 CCNB2 CCNB1 ORC6 ORC3 RAD21 ORC2 SMAD2 SMAD4 PLK1 CDC6 CDC2 STAG1 CDK7 STAG2 CDK2 ATR CDKN1C MCM7 ORC1L SMC1A SMC1B RBL2 CCNA2 RBL1 DBF4 TFDP1 ESPL1 TFDP2 MCM3 MCM5 MCM6 MCM2 HDAC2 PCNA HDAC1 TTK RB1 FZR1 CDC45 E2F4 E2F5 CDKN2D CDKN2B CDKN2C MAD2L2 WEE1 WEE2 CDKN2A CDK6 CDK4 HEL2 SFN CDKN1A CCND1 MYC YWHAQ HEL-S-1 YWHAG YWHAZ MDM2 E2F2 E2F3 GADD45B GADD45A GADD45G GSK3B CCND3 CDKN1B CCNE1 ATM CCNH SMC3 CDC14B CDC20 CDC23 CCND2 PTTG1 PTTG2 CHEK2 RETINOBLASTOMA GENE IN CANCER%WIKIPATHWAYS_20260510%WP2446%HOMO SAPIENS Retinoblastoma gene in cancer CHEK1 SKP2 CDC25B CCNE2 CDKN1A PRKDC CCNB2 CCNB1 CCND1 MYC CDC2 CDK2 MCM7 ORC1L SMC1A CCNA2 TFDP1 TFDP2 MCM3 MCM6 PCNA HDAC1 TTK RB1 CDC45 RBBP4 WEE1 TOP2A SUV39H1 FAF1 HMGB2 HMGB1 SMC2 SIN3A POLE RFC3 MDM2 RFC4 PRMT2 SAP30 MSH6 RBP1 CDK6 PRIM1 TYMS CDK4 POLD3 NPAT HLTF RBBP7 H2AZ1 BARD1 PLK4 CDT1 RRM1 RAF1 RRM2 RPA1 FANCG MAPK13 DHFR POLA1 POLE2 RPA3 CCDC6 ZNF655 E2F2 E2F3 CCND3 CDKN1B CCNE1 SMC3 PROLINE AND HYDROXYPROLINE PATHWAYS%WIKIPATHWAYS_20260510%WP5026%HOMO SAPIENS Proline and hydroxyproline pathways PRODH OCTADECANOID FORMATION FROM LINOLEIC ACID%WIKIPATHWAYS_20260510%WP5324%HOMO SAPIENS Octadecanoid formation from linoleic acid GPX4 CYP4A11 ALOX15 EPHX3 ALOX12B CYP3A4 PTGS2 CYP2C19 PTGS1 CYP2C9 CYP2C8 CYP1A2 ALOXE3 MIRNA BIOGENESIS%WIKIPATHWAYS_20260510%WP2338%HOMO SAPIENS miRNA biogenesis XPO5 DGCR8 DROSHA DICER1 TARBP2 RAN CYCLIN DEPENDENT KINASE 4 6 INHIBITORS IN BREAST CANCER%WIKIPATHWAYS_20260510%WP5497%HOMO SAPIENS Cyclin dependent kinase 4 6 inhibitors in breast cancer MTOR KRAS CDKN1A CDK6 MAPK3 CDK4 PIK3CD IGF1R RPTOR CCND1 MAPK1 RAF1 AKT3 HRAS PIK3R3 CDK2 PIK3R2 PIK3R1 NRAS PIK3CA CDKN1B CCNE1 EGFR IRS1 PIK3R4 PIK3C2G PIK3C2A INS PIK3C2B PIK3R5 ERBB2 MICRORNA NETWORK ASSOCIATED WITH CHRONIC LYMPHOCYTIC LEUKEMIA%WIKIPATHWAYS_20260510%WP4399%HOMO SAPIENS MicroRNA network associated with chronic lymphocytic leukemia ZAP70 BCL2 MCL1 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES APOPTOSIS%WIKIPATHWAYS_20260510%WP4864%HOMO SAPIENS Host pathogen interaction of human coronaviruses apoptosis BCL2 MCL1 APAF1 TNF MAPK12 BBC3 MAPK11 CASP8 BCL2L11 TNFSF6 FADD BCL2L1 BAD BAX CASP9 CASP3 MAPK14 MAPK13 IL5 SIGNALING%WIKIPATHWAYS_20260510%WP127%HOMO SAPIENS IL5 signaling STAT3 KRAS GSK3A GRB2 IL5RA CSF2RB SPRED1 FOXO3A MAPK3 JAK1 LYN STAT5B SYK STAT1 RPS6 RPS6KB1 RPS6KB2 MAPK1 BTK IL2 RAF1 MAP2K2 PIK3R2 PIK3R1 RPS6KA1 PTPN11 SOS1 GSK3B JUN SHC1 MAP2K1 PPAR ALPHA PATHWAY%WIKIPATHWAYS_20260510%WP2878%HOMO SAPIENS PPAR alpha pathway KLK15 CYP7A1 APOA5 CYP8B1 FABP1 RXRA CYP4A11 CPT2 EHHADH ACADM UGT1A9 PLTP CDK4 CCND1 SLC27A1 CPT1A MYC APOA2 APOC3 NR1H3 CDC2 NR1C1 DBI ERBB SIGNALING%WIKIPATHWAYS_20260510%WP673%HOMO SAPIENS ErbB signaling BCL2L11 MAPK9 MAPK8 CDKN1A PLCG2 MAPK3 STAT5B PIK3CD RPS6KB1 BRAF RPS6KB2 CCND1 MYC AKT3 HRAS MAP2K2 AREG CRKL NCK2 SOS1 NCK1 SOS2 MAP2K4 PDPK1 JUN NRG1 PIK3CA NRG2 SHC1 EREG SRC BTC NRG3 NRG4 CRK CAMK2D EGFR HBEGF FOXO1 SHC4 SHC3 CAMK2A TGFA CBL ERBB3 EIF4EBP1 PAK6 ABL2 PAK4 EGF MAPK10 MTOR MDM2 KRAS GRB2 CAMK2G ARAF MAPK1 RAF1 SHC2 PIK3R3 PIK3R2 PIK3R1 NRAS PAK1 ERBB4 BAD GSK3B PRKCB CDKN1B PRKCA MAP2K1 ERBB2 HAIR FOLLICLE DEVELOPMENT ORGANOGENESIS STAGE 2 OF 3%WIKIPATHWAYS_20260510%WP2839%HOMO SAPIENS Hair follicle development organogenesis stage 2 of 3 ITGB1 LAMA5 FOXI3 PDGFA SHH NCAM1 PTCH1 TP63 FZD1 TNLG7C INHBA RUNX2 GTPBP4 SMO BMP4 FGFR2 EDAR SNAI1 CCND1 GJB6 MYC NFKB1 PDGFRA CTNNB1 LEF1 LRP5 CCND2 FATTY ACID OMEGA OXIDATION%WIKIPATHWAYS_20260510%WP206%HOMO SAPIENS Fatty acid omega oxidation CYP4A11 CYP3A4 CYP1A2 ADH1C HEL-S-117 ADH1A ADH7 ADH6 CYP2A6 ALDH2 HEL-S-53e CYP1A1 CYP2E1 HEL-S-4 HEAD AND NECK SQUAMOUS CELL CARCINOMA%WIKIPATHWAYS_20260510%WP4674%HOMO SAPIENS Head and neck squamous cell carcinoma PRKAA2 CASP8 RELA FADD CDKN1A PTEN IGF1R RPS6 RPTOR RPS6KB2 CCND1 SMAD4 AKT3 MLST8 HRAS CTNNB1 TSC2 TSC1 PDPK1 PIK3CA RB1 EGFR EIF4EBP1 MTOR RHEB CDKN2A REL TP63 KRAS CDK6 FGFR3 CDK4 FGFR1 FKBP1A NFKB1 MAML1 KEAP1 STK11 SESN1 SESN2 PIK3R2 TGFBR2 PIK3R1 DDIT4 NRAS NUMB TRAF3 IRF6 AJUBA BIRC2 NOTCH2 PRKAA1 NOTCH1 MAPKAP1 TERT RICTOR CSMD3 EIF4E VEGFA NFKB2 FAT1 LTBR NFE2L2 PIK3R5 ERBB2 BETA GLOBIN GENE EXPRESSION REGULATION%WIKIPATHWAYS_20260510%WP5606%HOMO SAPIENS Beta globin gene expression regulation ZBTB7A tal-1 HBG2 LDB1 HBG1 LMO2 HBE1 HBB HBD GATA1 HDAC2 HDAC1 KDM1A BCL11A CHD3 NR2C2 GATAD2B KLF1 MYB MTA2 PPARGC1A ZFPM1 GNAQ PATHWAYS IN PORT WINE STAIN%WIKIPATHWAYS_20260510%WP5437%HOMO SAPIENS GNAQ pathways in port wine stain YAP1 MAP2K2 MAP2K3 TRIO MTOR AMOT MAP2K5 MAP2K4 MAPK3 PIK3CA MAPK1 RAC1 RAF1 MAP2K1 NFKB1 ARHA MAP2K6 IL9 SIGNALING%WIKIPATHWAYS_20260510%WP22%HOMO SAPIENS IL9 signaling MAP2K2 STAT3 PIK3R2 PIK3R1 IL2RG CDK9 IL9 JAK3 IL9R GRB2 MAPK3 JAK1 STAT5B STAT1 MAPK1 MAP2K1 GLYCINE METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260510%WP5028%HOMO SAPIENS Glycine metabolism including IMDs LIPT2 LIPT1 GLDC SHMT1 HEL-S-302 AMT HSCB LIAS NFU1 GCSH BOLA3 DLD ISCU NIPBL ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260510%WP5119%HOMO SAPIENS NIPBL role in DNA damage Cornelia de Lange syndrome H2AX ATR ATM RNF168 MDC1 NIPBL CBX3 RNF8 REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20260510%WP51%HOMO SAPIENS Regulation of actin cytoskeleton MAPK3 BRAF CYFIP2 ARHA NCKAP1 FGF2 ARHGAP35 MYLK ACTG1 FGF7 FGF8 FGF9 CFL2 PIP4K2A PIP4K2B HEL70 ACTN1 F2R MYL1 MYL3 PFN1 EZR PXN IQGAP1 PIK3CA HEL-S-15 FGF20 PIP5K1A PIP5K1C CD14 FGF23 MYH10 FGF22 FGF21 RDX RASSF7 ARPC5 SSH2 SSH3 FGF16 FGF14 FGF18 FGF13 FGF12 FGF10 BRK1 STM7 FGF8A PS1TP5BP1 PIP5KL1 TMSB4X BDKRB2 BDKRB1 RAC3 APC2 ITGA1 RRAS2 FGF7B F2 VAV1 FGF7A RRAS ARHGEF4 ARHGEF1 ARHGEF7 MAPK1 DOCK1 RAF1 ROCK1 ROCK2 WAS FGF6B CHRM2 FGD1 CHRM3 GNA13 CDC42 CHRM1 CSK CHRM4 WASF1 CHRM5 MAPK6 WASF2 MAPK4 LIMK1 FGF5C BAIAP2 MOS ABI2 PIK3R4 PIK3C2G PIK3C2A PIK3C2B PIK3R5 GNG12 PIK3CD PDGFRA MAP2K2 SOS1 SOS2 CRK EGFR PAK6 PAK4 EGF APC PDGFA KRAS FGFR4 FGFR3 FGFR2 FGFR1 HEL114 RAC1 PIK3R3 PIK3R2 PIK3R1 NRAS PAK1 MAP2K1 SHANK3 PATHWAY INVOLVED IN PHELAN MCDERMID SYNDROME%WIKIPATHWAYS_20260510%WP5566%HOMO SAPIENS SHANK3 pathway involved in Phelan McDermid syndrome ITGB1 PS1TP5BP1 ARHGEF7 HRAS CDC42 PAK1 BAIAP2 GRIA2 SPAAR CTNND2 ARHGAP44 SHARPIN RAP1A SYNGAP1 DLGAP1 MAP3K7 SPTAN1 LZTS3 HOMER1 GRIN2B GRIN1 DLG4 CAMK2A ADGRL1 SHANK3 HCN1 FBXL10 ENHANCEMENT OF MAP ERK SIGNALING IN DIFFUSE LARGE B CELL LYMPHOMA%WIKIPATHWAYS_20260510%WP4553%HOMO SAPIENS FBXL10 enhancement of MAP ERK signaling in diffuse large B cell lymphoma H2AB1 MACROH2A2 SUZ12 MACROH2A1 RNF2 H2AJ H3F3B H3C15 BCL6 EED PCGF1 BCOR MAPK3 H2AX EZH2 H2AZ1 MAPK1 H2AZ2 H3C8 H2AB3 PERTURBED THYROID HORMONE HOMEOSTASIS LEADING TO DEVELOPMENTAL NEUROTOXICITY%WIKIPATHWAYS_20260510%WP5517%HOMO SAPIENS Perturbed thyroid hormone homeostasis leading to developmental neurotoxicity SLCO1C1 SLC7A5 SLCO3A1 SLCO4A1 SLCO1A2 SLC16A10 SLC16A2 TH17 CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260510%WP5130%HOMO SAPIENS Th17 cell differentiation pathway ZAP70 MAPK8 PLCG1 IF2B1 JAK1 IL23R RORC TGFB1 CD3G RORA STAT1 IL27 AHR CD3E CD3D MAPK14 IL-21 SMAD2 IL2 IL27RA PPP3CA IFNGR1 TYK2 FOXP3 IL6R TGFBR1 RUNX1 IFNG IL23A LCK IRF4 CRY1 RXRA GATA3 HIF1A SOCS3 HLA-DMA NFIL3 RARA TBX21 IL21R NFATC1 NR1D1 IL4 JUN PER1 IL2RA IL17F LAT IL17A STAT3 MTOR IKBKB IL1B NFKBIA MAPK1 NFKB1 IL6 FOS PRKCQ LINOLEIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260510%WP5137%HOMO SAPIENS Linoleic acid oxylipin metabolism ALOX5 EPHX2 ALOX15 MFAP5 EFFECT ON PERMEABILITY AND MOTILITY OF ENDOTHELIAL CELLS VIA CYTOSKELETON REARRANGEMENT%WIKIPATHWAYS_20260510%WP4560%HOMO SAPIENS MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement CREB1 MYLK ACTN1 PLCG1 JUN PXN MAPK3 HEL114 ITGB3 LPP MAPK1 MFAP5 TJP1 MYL2 ITGAV PRKCQ T CELL RECEPTOR AND CO STIMULATORY SIGNALING%WIKIPATHWAYS_20260510%WP2583%HOMO SAPIENS T cell receptor and co stimulatory signaling CD8B1 ZAP70 NFATC2 CALM1 CD8A LCK CTLA4 FYN PTPN6 PDCD1 GSK3A GSK3B PLCG1 PTEN NFKBIA PRKCA IL2 PPP3CA NFKB1 ITK DYRK2 CSNK1A1 DYRK1A HEPATITIS C AND HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260510%WP3646%HOMO SAPIENS Hepatitis C and hepatocellular carcinoma STAT3 BRCA1 CXCR1 TNFSF6 FRZB NOS2 BCL2L1 MYOF GRB2 MAPK8 HNF1A VAV2 CDKN1A COL4A2 BIRC5 MAPK3 JAK1 HEL-117 CD44 TGFB1 BIRC3 CCND1 MAPK14 MYC RAC1 SMAD4 RRM2 NFKB1 IL6R TGFBR1 IL6 HIF1A E2F2 PTGS2 PTPN11 SOS1 CXCL8 JUN VEGFA CASP9 LEF1 CASP3 EFFECT OF OMEGA 3 PUFA ON HUNTINGTON 39 S DISEASE PATHWAYS%WIKIPATHWAYS_20260510%WP5470%HOMO SAPIENS Effect of omega 3 PUFA on Huntington 39 s disease pathways CREB1 GABRA3 REST RAB3GAP1 PRKAA2 MAPK9 MAPK8 MAPK3 SP1 BCL2 PIK3CA HDAC2 HDAC1 SIN3A IKBKB MAPK1 RAF1 NFKB1 PIK3R4 PIK3C2G PIK3C2A PIK3C2B PIK3R5 CASP8 BCL2L11 BCL2L1 PTEN PIK3CD RPTOR RPS6KB1 DEPTOR AKT3 MLST8 HRAS MAP2K2 TSC2 TSC1 AKT1S1 MAP2K4 EGFR EIF4EBP1 NTRK2 EGF MAPK10 MTOR RHEB IL1B CYP46A1 RPS6KA5 KIF5A PRKAB2 GABRG3 PRKAB1 GABRG2 GABRG1 ABCG4 ABCG1 NEUROD1 MBP PI3 APOE PIK3R3 ABCA1 PIK3R2 BDNF PIK3R1 MAP3K10 DHCR7 IL6 GABRB3 GABRB2 GABRB1 PRKAG1 PRKAG2 PRKAG3 PRKAA1 AHI-1 BAD OPA1 HMGCS1 HEL-S-29 RICTOR SREBF2 HAP1 EIF4E BAX C1QA HTT HMGCR GABRE SLC12A2 CASP3 GABRQ GABRA2 GABRP SLC12A5 GABRA6 MAP2K1 GABRA5 BNIP3 NR1H2 PPARGC1A GABRA4 CYP51A1 SEROTONIN HTR1 GROUP AND FOS PATHWAY%WIKIPATHWAYS_20260510%WP722%HOMO SAPIENS Serotonin HTR1 group and FOS pathway CREB1 GNAI1 MAP2K3 STAT3 RASGRF1 HTR2A HTR1E HTR1F HTR1D HTR1B MAPKAPK3 MAPKAPK2 5HT1A MAPK3 GNAO1 RPS6KA5 MAP3K1 BRAF MAPK1 MAPK14 MAP2K6 ARHA MAP2K2 RAP1A PDPK1 PIK3CA MAP2K1 GNAI3 FOS ARYL HYDROCARBON RECEPTOR PATHWAY%WIKIPATHWAYS_20260510%WP2873%HOMO SAPIENS Aryl hydrocarbon receptor pathway EP300 SLC7A5 MYOF MGST1 CYP1B1 IL12B UGT1A4 HES1 IL12A UGT1A3 TGFB1 IL1B UGT1A7 JUND CAP2 IGFBP1 AHR NCOA1 NQO1 SERPINB2 UGT1A1 IL2 PTGES3 POLK AIP CYP1A1 ALDH3A1 CDC37 AHRR CES3 IL17B IFNG TNF UGT1A9 JUN CYP1A2 BAX SRC CDKN1B NFE2L2 EGFR JUNB DOPAMINE METABOLISM%WIKIPATHWAYS_20260510%WP2436%HOMO SAPIENS Dopamine metabolism PPP2CA DDC TH MAOA PRKACG HEL-S-44 NQO1 TYR BMP2 WNT4 FOXO1 PATHWAY IN PRIMARY ENDOMETRIAL STROMAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260510%WP3876%HOMO SAPIENS BMP2 WNT4 FOXO1 pathway in primary endometrial stromal cell differentiation CTNNB1 BCL2L11 SMAD1 SMAD9 DKK1 DCN SFRP1 BMP2 SST DKFZp781O1323 LEFTY2 WNT4 FOXO1 CANCER IMMUNOTHERAPY BY PD 1 BLOCKADE%WIKIPATHWAYS_20260510%WP4585%HOMO SAPIENS Cancer immunotherapy by PD 1 blockade CD8B1 ZAP70 NFATC2 IFNG STAT3 CD8A LCK PDCD1 NFATC1 PTPN11 JUN NFAT5 NFATC3 CD3G PDCD1LG2 HLA-A NFATC4 CD3E BATF CD3D HLA-DRB1 NFKB1 PEROXISOMAL BETA OXIDATION OF TETRACOSANOYL COA%WIKIPATHWAYS_20260510%WP1941%HOMO SAPIENS Peroxisomal beta oxidation of tetracosanoyl CoA ACOX1 HSD17B4 GASTRIN SIGNALING%WIKIPATHWAYS_20260510%WP4659%HOMO SAPIENS Gastrin signaling CREB1 RELA MAPK9 MAPK8 PLCG1 MAPK3 SERPINB2 MAPK14 IL2 ARHA SP1 CTNNB1 TCF4 BMP2 PXN JUN PIK3CA ATF2 CLDN1 KAT5 MEF2C MEF2B SLC9A3 PRKD2 ARHGEF28 EGR1 YES1 MAP3K11 ELAVL1 MMP7 ANXA2 CDKN2A RHOD CCKBR GAS TFF2 PPARG HDC HDAC7 MEF2D KLF4 IKBKB LAMTOR3 NFKBIA CHUK MAPK1 RAF1 ROCK1 NFKB1 CDC42 PTGS2 PRKCH PRKCE PRKCA IRS1 PRKCQ PRKD1 BCL2L1 CDKN1A FOXO3A RPS6 RPS6KB1 CCND1 MYC HRAS ARRB2 KIT SOS1 SHC1 SRC CRK EGFR FOXO1 TJP1 EIF4EBP1 STAT3 ITGB1 FYN MTOR KRAS GRB2 BIRC5 CD44 BIRC3 RAC1 RHOB PIK3R3 PIK3R2 PIK3R1 PAK1 BIRC2 BAD PTPN11 GSK3B CXCL8 VEGFA CDKN1B CASP3 MAP2K1 FOS COMPLEMENT SYSTEM IN NEURONAL DEVELOPMENT AND PLASTICITY%WIKIPATHWAYS_20260510%WP5090%HOMO SAPIENS Complement system in neuronal development and plasticity DIABLO C1R APAF1 C5AR2 CFI C5AR1 HTRA2 CASP8 PARD6G ATP10A CFP PRKCZ TNFSF6 C4B_2 C2 VTN PARD6B PARD6A C6 C7 C9 CD59 DEDD TGFB1 CD55 MARK1 ATP8B3 ATP8B2 ATP8B1 HEL-S-62p MERTK AXL FAS CYCS PALS1 C1QC IFNG ITGB3 ITGAV FCN1 FCN2 PATJ FCN3 ITGAM PROS1 C4BPA C4BPB CLU C8A CX3CL1 C4A MBP C8G CASP10 ITGAX C3AR1 DLGAP5 MBL2 CAP1 CR2 CR1 ATP11C SCRIB BAK1 ATP11A PLSCR1 PLSCR3 PARD3 PLSCR4 TYRO3 SERPING1 BAX MASP2 C1QA CASP9 MASP1 CD46 MFGE8 LLGL2 CASP3 CFD CRB2 COLEC12 C1QB PRKCI CX3CR1 COLEC11 CRB1 COLEC10 C1S CFH CELL DIFFERENTIATION INDEX%WIKIPATHWAYS_20260510%WP2029%HOMO SAPIENS Cell differentiation index LEFTY1 LEFTY2 TLX3 TLX2 STAT3 TLX1 HDAC5 PRE IMPLANTATION EMBRYO%WIKIPATHWAYS_20260510%WP3527%HOMO SAPIENS Pre implantation embryo MACROH2A2 FOSB NANOGNB IRF4 AQP3 NR3C2 GATA3 FOXQ1 SOX2 ZFP36 DNMT3L KHSRP SIX3 SOX8 MYBL1 TEAD4 BATF3 FOXD1 SOX11 POU5F1 ZAR1 ARGFX DPPA3 DDIT3 ZFP42 DLX2 PADI6 E2F5 ATP1A1 GATA2 BARX2 ZFP36L2 LEUTX NKX2-1 MTA3 ESRRA EGR1 TFAP2B TCF7L1 CDX2 ELAVL1 IRX5 HMGA1 TPRX1 HNRNPAB PBX1 TBX3 DPRX SMARCA4 ZSCAN4 MXD1 KLF4 MOS RENIN ANGIOTENSIN ALDOSTERONE SYSTEM RAAS %WIKIPATHWAYS_20260510%WP4756%HOMO SAPIENS Renin angiotensin aldosterone system RAAS CREB1 CYP21A2 ITPR2 CAMK2G CYP11A1 ATF1 ATF6B CREB3L3 CREB3L4 CALML6 CREB3L2 CTSG CAMK1D HSD3B2 CAMK4 CALML3 CMA1 HSD3B1 CALML4 CREB3 CYP11B2 CAMK1 AGTR1 AGTR2 PLCB2 CAMK1G CREB5 STAR ATF4 CALM1 REN CAMK2D CAMK2A ATF2 SELENIUM METABOLISM AND SELENOPROTEINS%WIKIPATHWAYS_20260510%WP28%HOMO SAPIENS Selenium metabolism and selenoproteins SELS RELA NFKB1 RPL30 SP1 CREM HEL-S-134P SELENOF SELENOK SELENOI FABP1 SELENOH GPX4 SEPHS1 SEPHS2 PSTK EEFSEC GPX2 GPX1 POU2F1 TXNRD3 GPX3 TXNRD2 JUN GPX6 DIO1 TRNAU1AP SELENOO SEPSECS SELENON NFE2L2 SARS1 SELENOM SARS2 CTH SP3 SELENOP SELENOW SELENOV FOS SELENOT MSRB1 2Q13 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP5222%HOMO SAPIENS 2q13 copy number variation syndrome CHTM1 IL1RN CSF2 CSF1 ZC3H8 CXCL13 ZNRD1 BCL2L11 IL36A IL36B PSD4 ARL14 ANAPC1 CKAP2L IL1R1 IL1A PLCG2 POLR1A POLR1C POLR1D POLR1F POLR1G ARF6 STAT1 FBLN7 TMEM87B SLC20A1 RGPD8 TULP1 MERTK IL2 TTL IL1RL2 SOCS1 NT5DC4 POLR2F IL36RN POLR2H POLR2K IL23A POLR2L IL37 IL36G IL1F10 GATA3 SOCS3 GRB2 IL1B MAPK1 RAC1 IL6 FAMILIAL HYPERLIPIDEMIA TYPE 3%WIKIPATHWAYS_20260510%WP5110%HOMO SAPIENS Familial hyperlipidemia type 3 APOE SCARB1 LIPC LPL APOA4 VLDLR PLTP APOA2 LDLR OMEGA 9 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260510%WP4724%HOMO SAPIENS Omega 9 fatty acid synthesis ELOVL1 ELOVL5 ACSL1 ELOVL2 SCD5 ELOVL3 FACL4 ELOVL6 ACSL3 FADS2 SCD FASN FADS1 TCA CYCLE AND DEFICIENCY OF PYRUVATE DEHYDROGENASE COMPLEX PDHC %WIKIPATHWAYS_20260510%WP2453%HOMO SAPIENS TCA cycle and deficiency of pyruvate dehydrogenase complex PDHc PC OGDH SUCLG2 DLAT PCK1 HEL60 DLD FH PDHA1 HEL-S-32 SDHA HEL-S-26 CS ACLY SEROTONIN AND ANXIETY RELATED EVENTS%WIKIPATHWAYS_20260510%WP3944%HOMO SAPIENS Serotonin and anxiety related events PRKCB CRH HTR2A NLGN1 ARC PLEK CRHR1 PLCD4 PPP3CA 5HT1A FOS PYRIMIDINE METABOLISM AND RELATED DISEASES%WIKIPATHWAYS_20260510%WP4225%HOMO SAPIENS Pyrimidine metabolism and related diseases GLS2 AGXT2 DPYS CAD ABAT TYMP TYMS DHODH NT5C3A RRM2B DPYD HEL74 UMPS OTC RRM1 RRM2 AEROBIC GLYCOLYSIS AUGMENTED%WIKIPATHWAYS_20260510%WP4628%HOMO SAPIENS Aerobic glycolysis augmented HEL-S-49 HEL-S-87p HEL-S-30 PGAM2 HEL-S-133P GPT ENO1 HEL-S-68p PFKM HEL-S-162eP INSULIN SIGNALING IN ADIPOCYTES NORMAL CONDITION %WIKIPATHWAYS_20260510%WP3634%HOMO SAPIENS Insulin signaling in adipocytes normal condition TBC1D4 INSR SLC2A4 MTOR RPS6 RPS6KB1 IRS1 NAD METABOLISM IN ONCOGENE INDUCED SENESCENCE AND MITOCHONDRIAL DYSFUNCTION ASSOCIATED SENESCENCE%WIKIPATHWAYS_20260510%WP5046%HOMO SAPIENS NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence SLC2A4 MDH2 GOT2 SIRT5 IL6 NMNAT2 ELAVL1 RELA HMGA1 SIRT1 SIRT2 SIRT3 PRKAA1 NAMPT CCL27 IL1B HEL-S-32 PARP1 COPPER HOMEOSTASIS%WIKIPATHWAYS_20260510%WP3286%HOMO SAPIENS Copper homeostasis MT1A SCO1 MTF1 MT1F MT1G ADAM9 APC MT1B XAF1 STEAP1 MDM2 STEAP2 MT1E FOXO3A PTEN CCND1 SP1 HEL-S-44 APP STEAP3 STEAP4 GSK3B COX17 MT2A JUN ATP7B PIK3CA COX11 ATP7A PRNP SLC31A2 CASP3 SLC31A1 SLC11A2 FOXO1 ADAM10 COMMD1 MT4 MT3 ATOX1 BACE1 ADAM17 CCS INSULIN SIGNALING IN ADIPOCYTES DIABETIC CONDITION %WIKIPATHWAYS_20260510%WP3635%HOMO SAPIENS Insulin signaling in adipocytes diabetic condition TBC1D4 INSR SLC2A4 MTOR RPS6 RPS6KB1 IRS1 UTERINE NATURAL KILLER CELLS AND PROGESTERONE ESTROGEN AND CHORIONIC GONADOTROPIN%WIKIPATHWAYS_20260510%WP5569%HOMO SAPIENS Uterine natural killer cells and progesterone estrogen and chorionic gonadotropin MCL1 MAPK11 IL2RG JAK3 NR3C1 MRC1 MADCAM1 IL10 IL15RA JAK1 ITGA4 MAPK3 IL15 GAB3 STAT5B HLA-G NCR1 NCR2 NR3A2 NCR3 PGR CXCR4 KIR2DL4 CCL8 CCL7 CCL5 CXCR3 CCL4 CCL3 IFNG CCL2 BCL2 ANGPT2 VCAM1 ANGPT1 IL3 CXCL11 CXCL12 SELL IL2RB CD69 MAP2K4 IL4 GATA2 CX3CL1 TNF IL6 CXCL8 VEGFA PIBF1 WNT SIGNALING NETPATH%WIKIPATHWAYS_20260510%WP363%HOMO SAPIENS Wnt signaling NetPath NFATC2 MTOR BCL9 APC STM7 GSK3A MAPK9 MAPK8 TCF3 PPARG CDK6 CCND1 MAPK1 RAC1 ARHA CTNNB1 TSC2 TSC1 TCF4 ARRB2 CTBP1 NLK FRAT1 SOX1 GSK3B DVL1 DVL2 DVL3 TCF7L2 PRKCB MAP3K7 GCKR LEF1 RYK PRKCA LRP5 AXIN1 CSNK1D CSNK1E ROR1 LRP6 ROR2 PI4K2A CSNK1G1 CSNK1A1 VITAMIN B12 DISORDERS%WIKIPATHWAYS_20260510%WP4271%HOMO SAPIENS Vitamin B12 disorders TCN2 CBLIF TCN1 MTR MMACHC MMADHC CD320 CUBN AMN MTRR MMAA VISUAL CYCLE%WIKIPATHWAYS_20260510%WP5534%HOMO SAPIENS Visual cycle RDH8 ABCA4 RLBP1 RPE65 OPN1SW OPN1MW RDH12 OPN1LW RBP1 RBP3 RDH11 RDH10 RHO RDH5 LRAT PTDINS 4 5 P2 IN CYTOKINESIS PATHWAY%WIKIPATHWAYS_20260510%WP5199%HOMO SAPIENS PtdIns 4 5 P2 in cytokinesis pathway SEPTIN2 RAB35 KIF23 OCRL HEL70 MYL2 RDX ARHA EZR BLADDER CANCER%WIKIPATHWAYS_20260510%WP2828%HOMO SAPIENS Bladder cancer EGF CDKN2A MDM2 KRAS CDKN1A TYMP FGFR3 CDK4 ARAF RPS6KA5 BRAF CCND1 MAPK1 THBS1 RASSF1 MYC RAF1 MMP2 DAPK2 MMP9 HRAS UPK3A MAP2K2 PIK3R2 PIK3R1 NRAS CXCL8 VEGFA SRC RB1 EGFR HBEGF MAP2K1 ERBB2 MITOCHONDRIAL COMPLEX IV ASSEMBLY%WIKIPATHWAYS_20260510%WP4922%HOMO SAPIENS Mitochondrial complex IV assembly COX19 COX7B COX16 COX18 TACO1 COX4I1 COX7A2 HIGD1A COX6A1 COX7C COX5A COX3 COX2 COX14 COA6 CSRP2BP COX17 COX10 COX8A COA3 COX11 SURF1 PET100 FAM36A CMC1 COX6B1 TMEM177 PNKD COXFA4 SMIM20 PGK1 PKM2 KHKC KHKA ACTING AS PROTEIN KINASES%WIKIPATHWAYS_20260510%WP5433%HOMO SAPIENS PGK1 PKM2 KHKC KHKA acting as protein kinases H2AX STAT3 H3F3B HEL-S-30 AKT1S1 MYL2 SNAP23 KHK HEL-S-68p HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20260510%WP186%HOMO SAPIENS Homologous recombination POLD2 POLD3 MRE11A RAD52 NBN BRCA2 RAD54B ATM RPA1 POLD4 RAD50 RAD51 BIOMARKERS FOR PYRIMIDINE METABOLISM DISORDERS%WIKIPATHWAYS_20260510%WP4584%HOMO SAPIENS Biomarkers for pyrimidine metabolism disorders TYMS DHODH NT5C3A RRM2B DPYD HEL74 UMPS RRM1 RRM2 DPYS HEL-S-29 TYMP PRIMARY OVARIAN INSUFFICIENCY%WIKIPATHWAYS_20260510%WP5461%HOMO SAPIENS Primary ovarian insufficiency NBN BRCA2 NUP107 AMHR2 PRORP FMR1 PRDM1 ANTXR1 EIF4ENIF1 MEIOSIN POF1B MEIOB SIL1 NANOS3 ATG9A LARS2 PREPL CLPP MSH4 NOBOX KHDRBS1 BLM AARS2 AIRE ALOX12 MST1R HMMR WDR62 STAR STRA8 SYCE1 SOHLH1 KASH5 SOHLH2 SWI5 EIF2B5 EIF2B2 HELQ FANCM FANCL FANCA FANCC ERAL1 BMP6 DAZL GDF9 DIAPH2 STAG3 H1-8 HROB BMPR1A LHX8 BMPR2 BNC1 MCMDC2 MCM9 LAMC1 HSD17B4 ELAVL2 BMP15 EIF2B1 AMH POLG C1orf146 FIGLA MRPS22 FOXL2 NR5A1 TGFBR3 SIX6OS1 PPM1B HAX1 PCCA FSHR DMC1 PCCB ZP3 CYP17A1 PSMC3IP RECQL4 DCAF17 WRN PGRMC1 SLX4 POLR2C HSD17B1 LMNA CCDC185 MGME1 C10orf2 MND1 CENPE NLRP11 XPNPEP2 SPATA33 WT1 RFWD3 POLR3H NR3A2 SALL4 GNAS SOX8 ZAR1 TP63 NOTCH2 COX10 ATM RAD51 OSTEOARTHRITIC CHONDROCYTE HYPERTROPHY%WIKIPATHWAYS_20260510%WP5373%HOMO SAPIENS Osteoarthritic chondrocyte hypertrophy STAT3 RELA FGFR4 RUNX2 FGFR3 MAPK3 FGFR2 FGFR1 JUND MAPK1 FOSL2 AKT3 KDR NFKB1 FOSL1 CEBPB FOSB RELB CTGF ACAN HIF1A IBSP SPP1 COL10A1 VHL SOX9 CNMD P4HTM NGF GANC JUN COL1A1 VEGFA COL3A1 PIK3CA COL2A1 LAMTOR1 PRKCA DDR2 FGF23 JUNB NTRK1 FOS HALLMARK OF CANCER METASTASIS AND EPITHELIAL TO MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260510%WP5469%HOMO SAPIENS Hallmark of cancer metastasis and epithelial to mesenchymal transition SUZ12 SUV39H1 TCF4 SIRT1 EZH2 TGFB1 SNAI1 HDAC2 FOXC2 HDAC1 PRRX1 KDM1A SIX1 TWIST1 KLF8 ZEB2 ELF3 ELF5 SNAI2 GSC2 GANGLIO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260510%WP5299%HOMO SAPIENS Ganglio series sphingolipid metabolism NEU4 ST8SIA1 HEXB HEXA B3GALT4 ST8SIA5 ST3GAL5 B4GALNT1 ST8SIA6 SIAT4C ST3GAL1 NEU3 AIRWAY SMOOTH MUSCLE CELL CONTRACTION%WIKIPATHWAYS_20260510%WP4962%HOMO SAPIENS Airway smooth muscle cell contraction MYLK CALM1 RYR1 ADRB2 PPP1R14A GDI1 MYL1 IL13 HEL-S-80p PLCB1 ROCK1 ROCK2 ARHA PILOCYTIC ASTROCYTOMA%WIKIPATHWAYS_20260510%WP2253%HOMO SAPIENS Pilocytic astrocytoma NRAS BRAF KRAS RAF1 GRB2 PTPN11 SOS1 HRAS NF1 IL6 SIGNALING%WIKIPATHWAYS_20260510%WP364%HOMO SAPIENS IL6 signaling STAT3 PRDM1 BCL2L1 GRB2 CRP MAPK3 JAK1 TIMP1 CREBBP NR2F6 STAT1 VAV1 IRF1 VIP NCOA1 RPS6KB1 IL6ST MAPK1 RAC1 TYK2 IL6R MAP2K2 PIK3R2 PIK3R1 IL6 SOCS3 BAD NLK PTPN11 SOS1 GSK3B MAP2K4 SHC1 MAP3K7 HDAC1 JUNB MAP2K1 BEMPEDOIC ACID THERAPY IN ATHEROSCLEROSIS AND METABOLIC SYNDROME%WIKIPATHWAYS_20260510%WP5500%HOMO SAPIENS Bempedoic acid therapy in atherosclerosis and metabolic syndrome MAPK12 MAPK10 PRKAA2 MAPK11 HMGA1 ACACA MAPK9 MAPK8 CRP MAPK3 PRKAB2 ACACB MAPK1 PCK2 MAPK14 PRKAB1 G6PC1 G6PC2 G6PC3 SLC27A2 MAPK13 PRKAG1 PRKAG2 PRKAA1 PRKAG3 ACLY ERYTHROPOIESIS%WIKIPATHWAYS_20260510%WP5607%HOMO SAPIENS Erythropoiesis EPOR CD79A KITLG TF PTPRC HBZ IL3 IL3RA CD34 HBG2 TNFSF6 HBG1 KIT HBE1 HBB HBA2 HBD GATA1 FAS GATA2 GDF11 TFRC EPO DISORDERS OF BILE ACID SYNTHESIS AND BILIARY TRANSPORT%WIKIPATHWAYS_20260510%WP5176%HOMO SAPIENS Disorders of bile acid synthesis and biliary transport CYP7A1 CYP8B1 ABCC3 HSD3B7 ABCC2 ABCB1 ABCD3 ABCB4 SLC10A2 AKR1D1 SLC51A AKR1C4 BAAT SLC51B ABCB11 CYP7B1 CYP27A1 SLCO1B1 ATP8B1 AMACR FABP6 SLC27A5 HSD17B4 SLC27A2 MITOCHONDRIAL IMMUNE RESPONSE TO SARS COV 2%WIKIPATHWAYS_20260510%WP5038%HOMO SAPIENS Mitochondrial immune response to SARS CoV 2 CTSL IKBKE TICAM1 IRF3 IRF7 TLR7 TLR3 RIGI TRAF6 AGTR1 TOMM70 AGTR2 NLRX1 ACAD9 NFKB1 ECSIT MITA ACE2 MAVS TRAF3 REN NDUFAF1 NFKB2 NDUFB9 TMPRSS2 CGAS PHB2 IFIH1 TBK1 SERINE METABOLISM%WIKIPATHWAYS_20260510%WP4688%HOMO SAPIENS Serine metabolism TYMS SRR PSAT1 PHGDH HEL-S-51e PSPH DHFR SHMT1 ARACHIDONIC ACID AA ARA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260510%WP5155%HOMO SAPIENS Arachidonic acid AA ARA oxylipin metabolism EPHX2 PTGS2 PTGS1 ARSENIC METABOLISM AND REACTIVE OXYGEN SPECIES GENERATION%WIKIPATHWAYS_20260510%WP5233%HOMO SAPIENS Arsenic metabolism and reactive oxygen species generation ND1 COA3 HEL-S-44 ATP1A1 SDHA AS3MT HEL-S-21 UQCRFS1 G PROTEIN SIGNALING%WIKIPATHWAYS_20260510%WP35%HOMO SAPIENS G protein signaling PRKD1 GNAZ PRKCZ GNG12 GNG11 GNG13 GNAO1 GNB2 PPP3CA GNB1 GNAS ARHA HRAS GNB3 GNB5 CALM1 PRKACG GNGT1 PLCB3 GNAI3 ADCY3 ADCY1 ADCY8 GNAI1 ADCY6 GNG3 GNG5 GNG4 GNG7 GNA11 KRAS GNG8 KCNJ3 HEL159 AKAP12 AKAP10 AKAP11 GNGT2 PPP3CC RRAS PDE4B ARHGEF1 PDE4A PDE8A PDE4D PRKD3 AKAP9 PDE1C PDE1B PDE1A GNA13 AKAP8 AKAP7 AKAP6 AKAP5 AKAP4 NRAS GNA14 GNA15 GNG10 GNAL PDE7B PDE7A PRKCH PRKCB PRKCE PRKCA PRKCI ADCY9 PRKAR1B PRKAR1A PRKCQ PYRIMIDINE METABOLISM%WIKIPATHWAYS_20260510%WP4022%HOMO SAPIENS Pyrimidine metabolism POLR2B POLD2 POLR2D NT5M POLR2G POLR2I POLR2J POLR2J3 ZNRD1 DUT PNPT1 POLR2J2 POLR3GL POLE4 UCK2 POLA2 UCK1 POLR1A POLR3A POLR1C POLR3B POLR1D POLR3C POLR1F POLR3D POLE3 POLR3E POLR3F POLR3G POLR3K POLR2H POLR2K POLR2L POLE DPYS CAD PRIM1 TYMP TYMS DHODH POLD3 RRM2B DPYD HEL74 UMPS POLR2C RRM1 RRM2 POLA1 POLE2 POLR3H CDA ENPP1 ENPP3 TK1 ENTPD1 ENTPD3 NME2 NME3 CTPS2 CTPS1 NME4 DCTD NME6 NME7 CMPK1 CMPK2 UPRT DCTPP1 PRIM2 POLD4 DTYMK POLR2A SNARE COMPLEX MACHINERY IN EXOCYTOSIS%WIKIPATHWAYS_20260510%WP5621%HOMO SAPIENS SNARE complex machinery in exocytosis STX1B RIMS1 CACNA1B STXBP5 CACNA1A STXBP6 VAMP2 GDI1 NAPA SNAP25 UNC13A SYT1 STXBP1 SYP CPLX1 RPH3A ACETAMINOPHEN IN ANALGESIA AND ANTIPYRESIS%WIKIPATHWAYS_20260510%WP5444%HOMO SAPIENS Acetaminophen in analgesia and antipyresis FAAH TRPA1 KCNQ2 CACNA1H KCNQ3 TRPV1 PTGS2 5HT1A PTGS1 EICOSANOID METABOLISM VIA LIPOOXYGENASES LOX %WIKIPATHWAYS_20260510%WP4721%HOMO SAPIENS Eicosanoid metabolism via lipooxygenases LOX TRPA1 CYP4A11 ALOX15 EHHADH TRPV1 HEL-S-298 HPGD CYP4F2 CYP4A22 FPR2 LTC4S PTGR1 ALOX15B CYP4F12 LTB4R NR1C2 KPG_011 ALOX5 ACOX3 ACOX1 ALOX12 NR1C1 ETHANOL METABOLISM PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20260510%WP4269%HOMO SAPIENS Ethanol metabolism production of ROS by CYP2E1 MAP2K2 NFE2L2 MAFG MAFF MAFK MAP2K1 MAPK8 CYP2E1 SP1 EXTRACELLULAR VESICLES IN THE CROSSTALK OF CARDIAC CELLS%WIKIPATHWAYS_20260510%WP4300%HOMO SAPIENS Extracellular vesicles in the crosstalk of cardiac cells EGF STAT3 TLR4 IL6 HEL-S-44 SPP1 BIRC5 PTEN EGFR CD63 HEL-S-102 CD81 GATA4 KDR IGF1 MMP9 ETS2 GLP 1 SECRETION FROM INTESTINE TO PORTAL VEIN%WIKIPATHWAYS_20260510%WP5446%HOMO SAPIENS GLP 1 secretion from intestine to portal vein SLC2A2 GCG SLC5A1 PCSK1 COVID 19 ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260510%WP4891%HOMO SAPIENS COVID 19 adverse outcome pathway CCL3 CCL2 TNF CSF3 ACE2 IL7 IL6 IL10 CXCL8 IL2RA IL1B IL2 TMPRSS2 POLYCYSTIC KIDNEY DISEASE PATHWAY%WIKIPATHWAYS_20260510%WP2571%HOMO SAPIENS Polycystic kidney disease pathway PRKAA2 PLCG2 FLT1 MAPK3 IGF1R BRAF CCND1 MYC KDR GNAS HRAS MAP2K2 CTNNB1 TSC2 TSC1 PRKACG DVL1 DVL2 JUN DVL3 WNT4 SRC WNT1 GNAI3 IGF1 GNAI1 ADCY6 EGF MTOR WNT2B FZD10 PKD1 RHEB WNT5B WNT9B GNA11 WNT9A KRAS WNT16 FZD1 SSTR2 SFRP4 CFTR WNT8A WNT8B KCNN4 IKBKB WNT3 WNT10B WNT10A FZD3 PRKAB2 FZD2 FZD5 PRKAB1 FZD4 WNT3A WNT7B FZD7 FZD9 VEGFB WNT7A PDE1A FZD8 STK11 TNF NRAS RPS6KA1 PRKAG1 PRKAG2 PRKAG3 PRKAA1 GSK3B SLC12A2 FOS ERBB2 SLEEP REGULATION%WIKIPATHWAYS_20260510%WP3591%HOMO SAPIENS Sleep regulation CRH DLAT HTR2A NLGN1 IL18 STAR OXTR NPY2R OXT NPAS2 TH NPS CACNA1I IL6 HEL-S-2 DRD1 DRD2 DRD3 PTGDR CHRNB2 UTS2R MRGPRX2 BTBD9 HCRTR2 HCRTR1 PER3 ADORA2A MTNR1B GHRH UTS2 GHRL SLC29A1 ADA FOS FUMARATE HYDRATASE DEFICIENT PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260510%WP4241%HOMO SAPIENS Fumarate hydratase deficient papillary renal cell carcinoma SFPQ CTSK COL21A1 EP300 ELOC BIRC7 HIF1A RBX1 VHL CDKN1A DVL2 VEGFA CREBBP TGFB1 EGLN1 FH EGLN3 SETD2 TGFA EGLN2 CADM2 PRCC TFEB SMITH MAGENIS AND POTOCKI LUPSKI SYNDROME COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5381%HOMO SAPIENS Smith Magenis and Potocki Lupski syndrome copy number variation CREB1 YAP1 NT5M TLR4 RELA PRDM1 SHMT1 BLM CDC2 ARHA CFL2 JUN TRAF3IP1 IFT172 IFT52 PCK1 IFT57 IFT56 IFT80 IFT81 HEL-S-133P ROCK1 MAP3K14 NFKB1 IFT46 IFT70B LIMK1 IFT74 APP PARD3 TFEB IFT20 FOXA1 FHOD1 BCL6 IFT27 PARK2 BCL2L11 FERD3L GRIP1 ALKBH5 MAEA PPP1R14A CLUAP1 DENR PARD6B HES6 IFT25 MIGA1 MED9 ARMC8 RNF41 TOM1L2 PTEN RRAGA ULK1 LLGL1 DRC5 RPTOR DRC7 DRC8 FLII G6PC1 MYC GPR85 CLEC16A COPS7A PLD6 MLST8 NR1H3 RAI1 ATG101 WWTR1 TNFSF13 RAB39B COPS4 COPS6 IFT22 CRY1 COPS5 PEMT DRC1 COPS8 MYD88 CLTC GDI2 CLTB WDR41 CLTA FLCN PER1 RB1CC1 RAB8A ATPAF2 ARG2 RMI2 RMI1 TOP3A ITPK1 ETV5 DRC10 MYH2 TACI CRY2 IRF8 SMCR8 C9orf72 WDR26 GPS1 STAT3 MIEF2 RASD1 MTOR RMND5A FNIP1 FNIP2 RANBP9 MYO16 RAB10 MKLN1 GID4 MYO15A CARM1 DRG2 FOXA2 IL1B PRKAB1 TNF BIRC2 PRKAG2 PRKAA1 BAX PRKCI NR1H2 PRION DISEASE PATHWAY%WIKIPATHWAYS_20260510%WP3995%HOMO SAPIENS Prion disease pathway CREB1 EP300 STAT3 FYN NCAM1 MAPK3 SPI1 FGFR1 CTCF CHD2 HEL-S-125m HEL-S-89n TBP RAD21 HEL-S-269 MAPK1 PAX5 POU2F2 RFX5 NFKB1 BCL2 IRF4 RXRA CASP12 PRNP CASP3 BCL11A BATF SMC3 MEF2C VEDOLIZUMAB THERAPY FOR INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260510%WP5512%HOMO SAPIENS Vedolizumab therapy for inflammatory bowel disease ITGA4 VCAM1 ITGB1 SELPLG ITGA2 MADCAM1 ITGB7 SELE WHITE FAT CELL DIFFERENTIATION%WIKIPATHWAYS_20260510%WP4149%HOMO SAPIENS White fat cell differentiation CREB1 IRF3 TCF7L1 NR3C1 PPARG KLF4 STAT5B WNT10B RORA NR1H3 CEBPA CEBPD CTNNA1 EVI1 CEBPB ZNF423 TLE3 IRF4 EGR2 GATA3 NR2F2 KLF15 KLF2 KLF5 RARA DDIT3 FOXO1 GATA2 INS INFLUENZA A VIRUS INFECTION%WIKIPATHWAYS_20260510%WP1438%HOMO SAPIENS Influenza A virus infection BCL2 PHOTODYNAMIC THERAPY INDUCED HIF 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260510%WP3614%HOMO SAPIENS Photodynamic therapy induced HIF 1 survival signaling MCL1 NOS2 BCL2L1 BIRC5 IGFBP1 HEL-S-30 HEL-S-133P HEL-S-68p EPO ANGPT2 ANGPT1 HIF1A BAK1 BCL2A1 SLC2A3 PTGS2 PMAIP1 HIF1AN BNIP3L EDN1 IGFBP2 BAX VEGFA PFKL EGLN1 PDHA1 TGFA BNIP3 GLUTATHIONE METABOLISM%WIKIPATHWAYS_20260510%WP100%HOMO SAPIENS Glutathione metabolism GPX4 GPX2 GPX1 GPX3 HEL-S-64p GSTM2 GSTM1 GSTT2 OPLAH HEL-75 GCLC GSTA5 GCLM HEL-S-26 ULCERATIVE COLITIS SIGNALING%WIKIPATHWAYS_20260510%WP5174%HOMO SAPIENS Ulcerative colitis signaling IFNG TNF GATA3 IL2RG HLA-DMA IL13 NFATC1 IL10 IL4 TGFB1 NOD2 NFKB1 IL5 MAF FOXP3 MAP3K1 ROLE IN PROMOTING AND BLOCKING GONADAL DETERMINATION%WIKIPATHWAYS_20260510%WP4872%HOMO SAPIENS MAP3K1 role in promoting and blocking gonadal determination CTNNB1 FOXL2 MAPK11 FGF9 SOX9 FRAT1 GADD45G GSK3B FGFR2 WNT4 MAP3K1 AXIN1 MAPK1 ROCK1 ARHA SRY NEURAL CREST CELL MIGRATION DURING DEVELOPMENT%WIKIPATHWAYS_20260510%WP4564%HOMO SAPIENS Neural crest cell migration during development ARF1 EPHB2 PAK4 EPHB1 STAT3 TRIO EPHB4 EPHB3 TIAM1 CDH11 F2RL2 PIK3CD RAC1 AKT3 MMP2 MMP9 ARHA PIK3R3 BDNF PAK1 JUN PIK3CA TWIST1 PIK3R4 NGFR PIK3R5 FOS EPHB6 PAK6 METABOLIC REPROGRAMMING IN COLON CANCER%WIKIPATHWAYS_20260510%WP4290%HOMO SAPIENS Metabolic reprogramming in colon cancer SUCLG2 GLS HK3 PSAT1 SLC16A3 HEL-S-51e TIGAR PSPH HEL107 PGAM1 PYCR2 PAICS SDHB RPIA GLUD1 ACO2 ALDOB HEL-S-30 HEL-S-133P ENO1 HEL-S-68p HEL-S-162eP MDH2 GOT2 PFKL FASN FH PDHA1 ACLY CELL TYPE DEPENDENT SELECTIVITY OF CCK2R SIGNALING%WIKIPATHWAYS_20260510%WP3679%HOMO SAPIENS Cell type dependent selectivity of CCK2R signaling GNAI1 RYR1 RYR2 DAGLA CNR1 TRPC1 CCK RYR3 CCKBR PLCB1 NEURODEGENERATION WITH BRAIN IRON ACCUMULATION NBIA SUBTYPES PATHWAY%WIKIPATHWAYS_20260510%WP4577%HOMO SAPIENS Neurodegeneration with brain iron accumulation NBIA subtypes pathway MTOR RHEB ACACA DCAF17 ULK1 RPTOR DEPTOR PANK2 PLA2G6 WDR45 SPTLC1 MAP1LC3A MLST8 ATG5 ATG101 ATG3 STK11 ATG10 WIPI1 WIPI2 TSC2 C19orf12 TSC1 ATG14 CP COASY ATG12 FA2H ATG16L1 AKT1S1 PRKAA1 ATG2A FTL RB1CC1 PIK3R4 ONE CARBON METABOLISM%WIKIPATHWAYS_20260510%WP241%HOMO SAPIENS One carbon metabolism TCN2 MTR HEL-S-51e MTFMT AHCYL2 HEL-S-70p SHMT1 HEL-S-61p AMT GLRX TYMS MTHFS MAT1A FTCD FOLH1 MTHFD1L MTHFD1 MTHFD2 CHDH DNMT3B MTRR DHFR IL1 AND MEGAKARYOCYTES IN OBESITY%WIKIPATHWAYS_20260510%WP2865%HOMO SAPIENS IL1 and megakaryocytes in obesity HEL-S-134P IFNG CCL2 NLRP3 MYD88 F2R IL1R1 PIK3CA TIMP1 IL1B F2 HBEGF PLA2G7 TLR1 NFKB1 IRAK1 IL18 MMP9 FCER1A S100A9 CCR3 FGFR3 SIGNALING IN CHONDROCYTE PROLIFERATION AND TERMINAL DIFFERENTIATION%WIKIPATHWAYS_20260510%WP4767%HOMO SAPIENS FGFR3 signaling in chondrocyte proliferation and terminal differentiation CNP THRA NPR2 FGF18 IHH MAPK12 PTH1R PTHLH MAPK11 CDKN1A FGFR3 MAPK3 BMP4 SNAI1 STAT1 MAPK1 MAPK14 RAF1 MAPK13 ATG5 PPP2CA MAP2K2 FGF9 RBL1 SOX9 BMP2 MAP2K1 FGF23 SIGNALING IN HYPOPHOSPHATEMIC RICKETS AND RELATED DISORDERS%WIKIPATHWAYS_20260510%WP4790%HOMO SAPIENS FGF23 signaling in hypophosphatemic rickets and related disorders SLC34A3 KL GALNT3 SPP1 PTH SLC34A1 DMP1 CYP27B1 ENPP1 CYP24A1 CDKN1A FAM20C ALPL FGFR3 ROS1 FGFR2 NFKB2 FGF23 CCND1 CYP11B2 NFKB1 ORAI1 PI3K AKT MTOR SIGNALING AND THERAPEUTIC OPPORTUNITIES IN PROSTATE CANCER%WIKIPATHWAYS_20260510%WP3844%HOMO SAPIENS PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer MTOR RHEB KRAS FOXO3A FOXO4 PTEN GRB10 ULK1 RPTOR MLST8 HRAS PIK3R3 PIK3R2 PIK3R1 TSC2 NRAS BAD MAPKAP1 RICTOR GSK3B RB1CC1 PIK3CA CDKN1B FOXO1 EIF4EBP1 TFEB SARS COV 2 INNATE IMMUNITY EVASION AND CELL SPECIFIC IMMUNE RESPONSE%WIKIPATHWAYS_20260510%WP5039%HOMO SAPIENS SARS CoV 2 innate immunity evasion and cell specific immune response EP300 CSF2 CXCL13 CASP8 FADD IL10 JAK1 TFAP2A TGFB1 STAT1 CCL5 IL6R CCL4 CCL3 CCL2 CXCL11 CXCL12 HDAC2 TBK1 IRF3 IRF7 TLR7 RIGI CXCL6 CXCL9 IFITM1 TRADD CXCL17 TRAF6 CXCL1 CXCL3 CXCL2 CXCL5 IFIT2 NFKB1 AP1G1 DHX58 TRIM25 HAVCR2 IFNAR2 TNF LAG3 TRAF2 ACE2 hEMMPRIN MAVS TRAF5 IL6 TRAF3 NUP98 IFNAR1 TANK IL8RB LARP1 RIPK1 RAE1 IFNB1 CD160 STAT2 CXCL8 MX1 PPBP TP53I3 PF4 MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260510%WP4190%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway HMGCS1 HMGCR IDI1 FDPS MVK GGPS1 IDI2 ACAT2 ACAT1 HMGCL PMVK MVD FDFT1 KIT RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP304%HOMO SAPIENS Kit receptor signaling RPS6KA3 INPP5D EP300 SOCS6 STAT3 SH2B2 FYN MATK GAB2 PTPN6 DOK1 TEC GRB2 MAPK8 PLCG1 FOXO3A MAPK3 LYN GRB10 STAT5B STAT1 VAV1 RPS6 RPS6KB1 MAPK1 MAPK14 BTK RAF1 SOCS1 HRAS MAP2K2 PIK3R2 KITLG PIK3R1 RPS6KA1 KIT BAD CRKL PTPN11 SOS1 SHC1 PRKCB SRC PRKCA CRK MAP2K1 CBL GRB7 TRANSCRIPTIONAL ACTIVATION BY NRF2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20260510%WP3%HOMO SAPIENS Transcriptional activation by NRF2 in response to phytochemicals EPHB2 CEBPB SLC7A11 AIMP2 HMOX1 MAPK8 PIK3CA PRKCA NFE2L2 NQO1 GCLC GCLM MAF KEAP1 MICROGLIA PATHOGEN PHAGOCYTOSIS PATHWAY%WIKIPATHWAYS_20260510%WP3937%HOMO SAPIENS Microglia pathogen phagocytosis pathway PTPN6 NCF1 NCF2 ARPC1B VAV2 NCF4 PLCG2 RAC3 TREM2 TREM1 NCKAP1L LYN FCGR1A PIK3CD VAV3 SYK FCER1G VAV1 CYBB CYBA ITGAM TYROBP SIGLEC7 RAC1 C1QC PIK3R3 PIK3R2 PIK3R1 C1QA PIK3CA LAT C1QB PIK3C2A CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260510%WP5304%HOMO SAPIENS Cholesterol metabolism PCSK9 MSMO1 LIPA APOA2 TM7SF2 APOC3 LIPG CD36 STAR LBR PBR STARD3 CYP7A1 MYLIP ABCG8 ABCG5 DGAT1 SCARB1 NPC1 LIPC SOAT1 NPC2 LPL APOA4 ANGPTL8 ANGPTL3 PLTP LPA LDLR SLC27A4 LRPAP1 SAR1B MTTP HSD17B7 EBP NPC1L1 ABCB11 APOH SC5D CYP27A1 MGAT1 APOB SORT1 CIDEB DHCR24 FABP2 SQLE VAPA APOC2 APOC1 APOE ABCA1 DHCR7 HMGCS1 HMGCR IDI1 FDPS MVK ACAT2 PMVK MVD FDFT1 CYP51A1 MACROPHAGE MARKERS%WIKIPATHWAYS_20260510%WP4146%HOMO SAPIENS Macrophage markers CD163 CD83 CD68 LYZ F3 CD14 CD74 ANDROGEN RECEPTOR NETWORK IN PROSTATE CANCER%WIKIPATHWAYS_20260510%WP2263%HOMO SAPIENS Androgen receptor network in prostate cancer CHEK1 MRE11A CDC25B MAPK8 PRKDC MAPK3 HSD3B2 HSD3B1 BLM MAPK14 SMAD2 PLK1 CDC2 SP1 CDK2 BCL2 ATR PXN JUN PIK3CA RB1 SMARCD1 SMARCD2 SMARCD3 HSD17B4 CDKN2B SMARCC1 SMARCC2 ACTL6B CDKN2A ACTL6A ARID1A ARID1B MSH6 SMARCA4 CYP17A1 CDK4 BARD1 HSD17B1 MAPK1 DOCK1 RAF1 RAP1A FOXA1 CASP8 CDKN1A JAK1 PTEN STAT1 RPTOR CCND1 MYC HRAS MAP2K2 TSC2 TSC1 CRKL SOS1 HSD17B7 CRK EIF4EBP1 STAT3 MTOR SPINK1 HGF MSH2 RHEB BRCA1 EIF4E1B ERG MDM2 FKBP5 KLK3 GRB2 NOXA1 F13B MAP4K1 ATF1 ETV4 RAPGEF1 HSD17B3 CPN1 HSD17B2 PTK2B SPRY2 SPRY1 PAK1 BAD PTPN11 RICTOR BAX CASP9 CDKN1B ATM CASP3 MAP2K1 FOS RAD50 CHEK2 DIFFERENTIATION OF WHITE AND BROWN ADIPOCYTE%WIKIPATHWAYS_20260510%WP2895%HOMO SAPIENS Differentiation of white and brown adipocyte PRDM16 HOXC9 HOXC8 CEBPB ZNF423 PPARGC1B MPZL2 SMAD1 SMAD9 BMP2 PPARG DKFZp781O1323 BMP4 DGIC CEBPG HSPB7 CIDEA EBF3 SLC7A10 BMP7 LEP PPARGC1A CEBPA ZIC1 GLUCOSE METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260510%WP5211%HOMO SAPIENS Glucose metabolism in triple negative breast cancer cells PPM2C PFKP HEL-S-30 HEL-S-133P SMC1 SMC3 ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260510%WP5118%HOMO SAPIENS SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome MRE11A NBN ATM SMC1A PAXIP1 RAD21 BRCA1 SMC3 RAD18 MDC1 RAD50 SEROTONIN AND ANXIETY%WIKIPATHWAYS_20260510%WP3947%HOMO SAPIENS Serotonin and anxiety CRH HTR2A ARC FMR1 PLEK ADRA1A TRPV1 EEF2K PLCD4 5HT1A PRKCB POMC PPP3CA FOS CONVERSION OF ANGIOTENSINOGEN TO ANGIOTENSIN II %WIKIPATHWAYS_20260510%WP4818%HOMO SAPIENS Conversion of angiotensinogen to angiotensin II CTSG CMA1 HEL-S-130P REN SMALL LIGAND GPCRS%WIKIPATHWAYS_20260510%WP247%HOMO SAPIENS Small ligand GPCRs PTGDR PTGER4 PTGFR PTGIR PTGER1 PTGER2 PTGER3 LPAR1 GPR50 MTNR1A MTNR1B CNR2 TBXA2R CNR1 S1PR1 S1PR3 S1PR2 S1PR4 DOCOSAHEXAENOIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260510%WP5154%HOMO SAPIENS Docosahexaenoic acid oxylipin metabolism EPHX2 PTGS2 MIR 124 PREDICTED INTERACTIONS WITH CELL CYCLE AND DIFFERENTIATION %WIKIPATHWAYS_20260510%WP3595%HOMO SAPIENS mir 124 predicted interactions with cell cycle and differentiation STK11 PTBP1 PRKAA1 SIX4 CTDSP1 STRADB 15Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP4940%HOMO SAPIENS 15q11 2 copy number variation syndrome NIPA1 TUBGCP6 TUBGCP4 NIPA2 FMR1 CYFIP1 TUBGCP5 THIAMINE METABOLIC PATHWAYS%WIKIPATHWAYS_20260510%WP4297%HOMO SAPIENS Thiamine metabolic pathways OGDH BCKDK TPK1 SLC19A3 DKFZp667O1614 SLC19A2 PDHA1 HEL107 MOLECULAR PATHWAY FOR OXIDATIVE STRESS%WIKIPATHWAYS_20260510%WP5477%HOMO SAPIENS Molecular pathway for oxidative stress CREB1 CHEK1 MAP2K3 MTOR RHEB NRF1 MDM2 HMOX1 GSX1 NOS2 BCL2L1 IPCEF1 MAPK8 PINK1 PIP CDKN1A IL1A PTEN IKBKB RPS6KA5 NQO1 MAPK14 IKBKG NFKB1 KEAP1 CDK2 BCL2 TNF ATR TSC1 IL6 SIRT1 PTGS2 MAP2K4 CXCL8 PIK3CA CCNE1 NFE2L2 FOXO1 MAP3K5 ATF2 FOS NOTCH1 REGULATION OF ENDOTHELIAL CELL CALCIFICATION%WIKIPATHWAYS_20260510%WP3413%HOMO SAPIENS NOTCH1 regulation of endothelial cell calcification NOTCH1 GJA5 JAG2 PLAT ALPL FGFR3 ITGA1 DLL3 LPAR1 VEGFA DLL4 MGP CALU SOX6 PHOSPHATIDYL INOSITOL PHOSPHATE PATHWAY%WIKIPATHWAYS_20260510%WP5411%HOMO SAPIENS Phosphatidyl inositol phosphate pathway INPP5D STM7 PLCD4 PLCG2 PLCG1 PLCB1 PTEN PIK3CD MTMR1 PI4K2B MTMR2 MTMR8 OCRL MTMR6 MTM1 PIP4P2 PLCB2 PIP4P1 PLCE1 TPTE2 SACM1L IPMK FIG4 INPP4A INPP4B PIKFYVE PLCB4 PI4KB PIP4K2A PLCD3 PIP4K2B INPP5E PLCB3 PIK3CA PIP5K1A PIP5K1C PIK3C2G PI4K2A PIK3C2A PIK3C2B MAMMALIAN DISORDER OF SEXUAL DEVELOPMENT%WIKIPATHWAYS_20260510%WP4842%HOMO SAPIENS Mammalian disorder of sexual development WT1 CTNNB1 FOXL2 NR5A1 MAPK11 FGF9 AMHR2 EMX2 RBFOX2 DMRT1 PBX1 DHH SOX9 CBX2 FST SOX8 RSPO1 INSL3 FGFR2 WNT4 GATA4 SRY AMH MITOCHONDRIAL FISSION AND FUSION%WIKIPATHWAYS_20260510%WP4318%HOMO SAPIENS Mitochondrial fission and fusion FIS1 BAX MTFP1 MFN1 MFN2 SH3GL2 BCL2L1 OPA1 BNIP3 MIB1 MICRORNA FOR TARGETING CANCER GROWTH AND VASCULARIZATION IN GLIOBLASTOMA%WIKIPATHWAYS_20260510%WP3593%HOMO SAPIENS MicroRNA for targeting cancer growth and vascularization in glioblastoma HES1 VEGFA VEGFC HIF1A VEGFB HIF1AN MAMMARY GLAND DEVELOPMENT INVOLUTION STAGE 4 OF 4%WIKIPATHWAYS_20260510%WP2815%HOMO SAPIENS Mammary gland development involution stage 4 of 4 BAX STAT3 CHI3L1 IL6ST SOCS3 MYC MMP9 SIGNAL TRANSDUCTION THROUGH IL1R%WIKIPATHWAYS_20260510%WP4496%HOMO SAPIENS Signal transduction through IL1R IL1RN MAP2K3 RELA MAPK8 IL1R1 IL1A IKBKB TGFB1 IL1B NFKBIA MAP3K1 CHUK TRAF6 MAPK14 MAP3K14 NFKB1 MAP2K6 ECSIT TNF IL6 MYD88 IFNB1 JUN MAP3K7 IFNA1 IRAK2 IRAK3 MAP3K7IP1 IRAK1 CHEMOKINE SIGNALING%WIKIPATHWAYS_20260510%WP3929%HOMO SAPIENS Chemokine signaling TIAM1 CXCL13 RELA JAK3 MAPK3 BRAF PRKACG PLCB4 PXN PIK3CA CXCL14 CXCL16 PREX1 ELMO1 GRK1 CCR3 CCR10 CCR1 XCR1 NFKBIB WASL CCR8 CCR7 CCR6 CCR4 CCR2 XCL1 DOCK2 CCL11 CXCR5 PRKX CXCR6 ADRBK1 CCL1 IKBKB CCL19 NFKBIA CCL17 CXCL9 VAV1 CCL15 CHUK CCL25 CCL24 CCL22 MAPK1 CCL21 CXCL3 IKBKG CCL20 RAF1 ROCK1 c-fgr CXCL5 ROCK2 CCL28 NFKB1 WAS CCL26 CX3CL1 CDC42 CSK IL8RB CCL27 PARD3 STAT2 RAP1A PPBP PRKCB PF4 ADCY9 CX3CR1 PIK3R5 PRKCZ GRK5 NCF1 GRK4 GNG12 FOXO3A GNG11 PLCB1 GNG13 LYN STAT5B PIK3CD VAV3 STAT1 GNB2 CXCR4 AKT3 GNB1 CCL7 GNB4 CCL5 GNB3 HRAS CXCR3 GNB5 CCL4 CCL3 CXCL11 ARRB2 CXCL12 GNGT1 CRKL SOS1 SOS2 PLCB3 SHC1 CRK SHC4 SHC3 GNAI3 ITK ADCY3 ADCY1 ADCY8 GNAI1 ADCY6 STAT3 GNG3 GNG2 GNG5 GNG4 GNG7 KRAS GRB2 GNG8 VAV2 PTK2B GNGT2 RAC1 PLCB2 SHC2 PIK3R3 PIK3R2 PIK3R1 NRAS PAK1 GNG10 GSK3B MAP2K1 FATTY ACID AND LIPOPROTEIN TRANSPORT IN HEPATOCYTES%WIKIPATHWAYS_20260510%WP5323%HOMO SAPIENS Fatty acid and lipoprotein transport in hepatocytes SLC27A1 PCSK9 LIPA SLC27A2 ACSL6 ACSL5 STAR DBI FABP4 APOE SOAT2 ABCA1 STARD3 SLC27A3 MYLIP FABP1 SCARB1 SOAT1 NPC2 APOA4 LDLR LPA SLC27A4 ACSL1 ACSL3 APOB SORT1 FABP2 APOC2 APOC1 SREBF AND MIR33 IN CHOLESTEROL AND LIPID HOMEOSTASIS%WIKIPATHWAYS_20260510%WP2011%HOMO SAPIENS SREBF and miR33 in cholesterol and lipid homeostasis ABCA1 MED15 MTOR SIRT1 PRKAA1 LDLR HMGCS1 SREBF2 HMGCR SCD FASN NR1H3 NR1C1 SIRT6 PPARGC1A 2Q37 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP5224%HOMO SAPIENS 2q37 copy number variation syndrome ARF1 UGT1A4 HES1 UGT1A3 UGT1A7 UGT1A1 MAP1LC3A JUN TRAF3IP1 MEF2C NFKBIA MROH2A UGT1A10 DGKD NDUFA10 HJURP ERFE KLHL30 IL13RA1 GABARAPL2 GABARAPL1 EEF1A1 THAP4 RRAGB RRAGD CALCA CALCRL TWIST2 AGAP1 GABARAP OR6B3 MAP4 TRPM8 OR6B2 UBE2F MTERF4 RAB27A HAMP COPS9 SNED1 NEU4 RTP5 RNPEPL1 PRH PRL ING5 GYS1 SEPT6 MAP1LC3C KIF1A GAL3ST2 ILKAP BOK MYOG HES6 AQP12B AQP12A DUSP28 ANO7 OTOS HEL-S-28 RRAGA ARL4C MYOD1 RPS6 DKFZp762B153 USP40 AGXT ARF5 CXCR4 NEDD8 ASCL1 ASB18 CENPA CYTH2 GBX2 PPP1R7 GPC1 CALM1 SH3BP4 SPP2 D2HGDH DISC1 UGT1A8 CXCL11 ANKMY1 CXCL12 CYTH1 FARP2 COPS8 UGT1A9 PDX1 SEPTIN4 PER2 MLPH CAPN10 ACKR3 RAB17 RAMP1 ASB1 ITGB3 EGFR ITPK1 IRF8 PDCD1 PDGFA IL1B SEPTIN2 RAC1 ABCA1 TNF TRAF3 DTYMK ACUTE MYELOID LEUKEMIA%WIKIPATHWAYS_20260510%WP5293%HOMO SAPIENS Acute myeloid leukemia CSF2 RELA FLT3 MAPK3 FCGR1A STAT5B PIK3CD NR1C2 JUP RPS6KB1 BRAF RPS6KB2 CCND1 MYC AKT3 HRAS RUNX1 MAP2K2 IL3 CCNA2 KIT RARA PER2 SOS1 SOS2 PIK3CA CSF1R MPO TCF7L2 PIM1 PIM2 LEF1 CEBPE CD14 RUNX1T1 EIF4EBP1 ZBTB16 STAT3 PML TCF7L1 MTOR KRAS GRB2 SPI1 IKBKB ARAF CHUK ITGAM MAPK1 IKBKG RAF1 NFKB1 CEBPA PIK3R3 PIK3R2 PIK3R1 NRAS BCL2A1 BAD MAP2K1 PANCREATIC CANCER SUBTYPES%WIKIPATHWAYS_20260510%WP5390%HOMO SAPIENS Pancreatic cancer subtypes TSPAN8 VSIG2 AGR2 AGR3 LYZ FAM3D TNS4 KRT6C FAM83A KRT6A SERPINB3 BTNL8 FGFBP1 S100A2 TFF2 REG4 KRT7 ANXA10 LEMD1 DHRS9 CEACAM6 SCCA2 PLA2G10 LY6D TFF3 TFF1 VGLL1 CLRN3 CDH17 SPRR1B AREG SPRR3 ANXA8L1 ST6GALNAC1 GPR87 HEL136 KRT20 CST6 CYP3A7 LGALS4 SCEL EXTRACELLULAR VESICLE MEDIATED SIGNALING IN RECIPIENT CELLS%WIKIPATHWAYS_20260510%WP2870%HOMO SAPIENS Extracellular vesicle mediated signaling in recipient cells TSPAN8 CTNNB1 TGFBR2 MTOR NRAS TGFBR3 HGF APC KRAS MET TGFB1 MFGE8 AXIN1 EGFR SMAD2 WNT3A SMAD4 RAF1 TGFA DKK4 CD133 HRAS TGFBR1 ERBB2 MRNA PROCESSING%WIKIPATHWAYS_20260510%WP411%HOMO SAPIENS mRNA processing DHX38 SRPK2 CPSF4 CPSF1 FUS CPSF3 NONO CPSF2 SUPT5H WDR57 SFRS3 CLK4 LSM2 CLK2 SRPK1 HNRNPL CLK1 LSM7 HNRNPK HNRNPD RNPS1 CLASRP HNRNPC DKFZp434N041 SUGP2 SUGP1 CELF1 CELF2 CELF4 SRP54 YBX1 DHX15 DHX16 RBM5 RBM17 NCBP1 NCBP2 PRMT1 PRPF40A SMC1A PRPF18 NHP2L1 HNRNPH1 SNRPA1 DNAJC8 SF3B5 SF3B2 RNMT CSTF2T U2AF1 PPM1G PABPN1 U2AF2 TRA2B SPOP SNRPB2 SF3B1 SRSF10 SF3A1 SF3A2 NUDT21 PHF5A HNRNPA2B1 RBMX PRMT2 DICER1 SFPQ HNRNPAB SNRPD2 SNRPD1 HNRPR CLP1 PAPOLA SNRPD3 TXNL4A PSKH1 SNRPN METTL3 PRP4K CDC40 PRPF4 PRPF6 PRPF3 SNRPG SRSF4 SNRPE SNRPF SREK1 SRSF6 SRSF7 SNRPA SNRPB SRSF9 TMED10 DHX8 DDX1 CSTF3 PTBP1 CSTF2 PRPF8 SFRS5 SFRS8 CSTF1 POLR2A HISTONE MODIFICATIONS%WIKIPATHWAYS_20260510%WP2369%HOMO SAPIENS Histone modifications SETD4 SUV39H2 SETD5 SUV39H1 SET SETD3 KMT2A H3C15 H3F3B SETD8 SMYD5 EED SETD9 KMT2C SETD6 KMT2B DOT1L SETD7 EHMT1 PRDM2 SMYD2 SMYD1 EZH2 KMT5B SMYD4 SMYD3 H4C7 MLL2 H4C9 SETDB1 KMT5C HIST1H4L SETD1B SETD1A SETDB2 SETMAR ASH1L AEBP2 SETBP1 EZH1 SETD2 H3C8 KMT2E MULTIPLE SCLEROSIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260510%WP5540%HOMO SAPIENS Multiple sclerosis mechanism and therapies ITGA4 HEL-S-171mP ITGB1 S1PR5 MS4A1 S1PR1 S1PR3 BTK S1PR4 CREATINE PATHWAY%WIKIPATHWAYS_20260510%WP5190%HOMO SAPIENS Creatine pathway SLC6A8 HEL-S-20 HEL-S-29 THYROID STIMULATING HORMONE TSH SIGNALING%WIKIPATHWAYS_20260510%WP2032%HOMO SAPIENS Thyroid stimulating hormone TSH signaling CREB1 MAP2K3 PLCB1 JAK1 MAPK3 GNAO1 STAT1 IGF1R RPS6 RPS6KB1 BRAF MAPK14 GNB1 GNAS HRAS CDK2 RBL2 PDPK1 PIK3CA SRC RB1 GNAI3 ADCY3 GNAI1 STAT3 MTOR GNG2 CDK4 MAPK1 PDE4D RAF1 MAP2K6 GNA13 PIK3R2 PIK3R1 RPS6KA1 TSHB SCRIB RAP1GAP MYL12B CGA KCNIP3 TSHR APEX1 RAP1A CCND3 CDKN1B CCNE1 MAP2K1 ARYL HYDROCARBON RECEPTOR RESPONSE TO MAIN MEDIATORS PAH AND TCDD%WIKIPATHWAYS_20260510%WP2586%HOMO SAPIENS Aryl hydrocarbon receptor response to main mediators PAH and TCDD EP300 RELA KRAS CYP1B1 CDKN1A CCL1 AHR NQO1 MAPK1 MYC RAF1 AIP CYP1A1 NFKB1 CDC37 CD36 HRAS AHRR CDK2 TNF NRAS LPL PTGS2 RET NF1 PLAGL1 CYP1A2 VEGFA NCOR2 KLF6 SRC NCOA7 CDKN1B NFE2L2 RB1 EGFR GCLC FGF21 MAP2K1 SARS COV 2 B 1 1 7 VARIANT ANTAGONISES INNATE IMMUNE ACTIVATION%WIKIPATHWAYS_20260510%WP5116%HOMO SAPIENS SARS CoV 2 B 1 1 7 variant antagonises innate immune activation IKBKE IRF3 MAVS TRAF3 TRAF6 RIGI TOMM70 IFNB1 TBK1 IL18 SIGNALING%WIKIPATHWAYS_20260510%WP4754%HOMO SAPIENS IL18 signaling CASP8 RELA TNFSF6 NCF1 MAPK9 NCF2 MAPK3 PTEN IRF1 RPS6KB1 ACACB FAS CYCS SP1 CTNNB1 LCK IL37 MYD88 GATA1 NFATC4 HEL-S-102 IRAK1 ELAVL1 IKBKB NFKBIA CHUK TRAF6 MAPK1 NFKB1 IL18 TNF CEBPB PIK3R1 PRKAA1 GSK3B BAX PRKCB MAP3K7 CSN2 PRKCA IL18RAP CASP3 TICAM2 IMP3 GRIN2B TNFRSF1A SLC12A3 IL18R1 PARP1 KLEEFSTRA SYNDROME%WIKIPATHWAYS_20260510%WP5351%HOMO SAPIENS Kleefstra syndrome PAGR1 ASXL1 WDR5 SMARCC1 BAP1 SMARCC2 H3F3B RXRA ACTL6B PAXIP1 KMT2C ACTL6A ARID1A ARID1B SMARCA4 EHMT1 SMARCD1 SMARCD2 SMARCD3 MBD5 NCOA6 NR1I3 DPY30 ASH2L TARGET OF RAPAMYCIN SIGNALING%WIKIPATHWAYS_20260510%WP1471%HOMO SAPIENS Target of rapamycin signaling PRR5 MTOR PRKAA2 DDIT4L RHEB RRAGA FKBP1A ULK1 RPTOR PRKAB2 RPS6KB1 PRKAB1 RAC1 MLST8 CDC42 TSC2 TSC1 DDIT4 PRKAG1 PRKAG2 AKT1S1 PRKAA1 PRKAG3 MAPKAP1 ULK2 RICTOR RRAGB RRAGD HMGCR IDI1 PRKCA EIF4EBP1 GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260510%WP661%HOMO SAPIENS Glucose homeostasis INS NUCLEOTIDE EXCISION REPAIR%WIKIPATHWAYS_20260510%WP4753%HOMO SAPIENS Nucleotide excision repair POLD2 CETN2 XPA RBX1 XPC POLE GTF2H2C_2 RFC3 RFC4 LIG1 RFC1 POLE4 RFC2 GTF2H2 GTF2H3 GTF2H5 CUL4A POLD3 DDB1 ERCC1 POLE3 ERCC2 ERCC5 MNAT1 CUL4B RPA1 DDB2 CDK7 POLE2 RPA3 PCNA CCNH POLD4 TRANSCRIPTION FACTOR REGULATION IN ADIPOGENESIS%WIKIPATHWAYS_20260510%WP3599%HOMO SAPIENS Transcription factor regulation in adipogenesis CEBPD CREB1 INSR SLC2A4 TNF CEBPB IL6 RXRA NR3C1 MAPK8 PPARG LPIN1 IRS1 TWIST1 FOXO1 PCK2 LEP PPARGC1A CEBPA NRF2 ARE REGULATION%WIKIPATHWAYS_20260510%WP4357%HOMO SAPIENS NRF2 ARE regulation INSR EPHB2 CEBPB YES1 FYN RBX1 SLC7A11 AIMP2 HMOX1 MAPK8 GSK3B PIK3CA SRC PRKCA NFE2L2 NQO1 GCLC PGAM5 GCLM MAF KEAP1 LTF DANGER SIGNAL RESPONSE PATHWAY%WIKIPATHWAYS_20260510%WP4478%HOMO SAPIENS LTF danger signal response pathway TNF TLR4 IL6 MYD88 IFNB1 IL1A CXCL8 TREM1 IL1B CD14 IFNA1 TRAF6 MAPK1 IRAK4 HEL110 AGER NFKB1 IRAK1 TARGETED THERAPY IN BREAST CANCER%WIKIPATHWAYS_20260510%WP5496%HOMO SAPIENS Targeted therapy in breast cancer PIK3R3 PIK3R2 PIK3R1 NRAS ERBB4 KRAS MAPK3 PIK3CA PIK3CD EGFR MAPK1 PIK3R4 PIK3C2G RAF1 PIK3C2A AKT3 PIK3C2B ERBB3 PIK3R5 HRAS ERBB2 IL23 INHIBITORS IN INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260510%WP5516%HOMO SAPIENS IL23 inhibitors in inflammatory bowel disease IFNG STAT3 TNF IL23A CSF2 TLR4 IL12B IF2B1 STAT5B RORC IL17F STAT1 IL17A STAT4 TYK2 IL12RB1 TYPE I COLLAGEN SYNTHESIS IN THE CONTEXT OF OSTEOGENESIS IMPERFECTA%WIKIPATHWAYS_20260510%WP4786%HOMO SAPIENS Type I collagen synthesis in the context of osteogenesis imperfecta FZD1 PLOD2 TNFRSF11B MIA3 TNFRSF11A PLOD1 ADAMTS2 TNFSF11 TMEM38B COLGALT1 IFITM5 MBTPS1 CRTAP P3H2 P3H1 COL1A2 BMP1 LOX P4HA1 COL1A1 P4HA2 SP7 PPIB MBTPS2 LRP5 LRP6 WNT1 MITOCHONDRIAL LONG CHAIN FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260510%WP368%HOMO SAPIENS Mitochondrial long chain fatty acid beta oxidation CPT2 EHHADH ACADM ACSL1 FACL4 PECR ACSL3 ACADVL ACSF2 ACADL SLC25A20 ACADS CPT1A FOLATE METABOLISM%WIKIPATHWAYS_20260510%WP176%HOMO SAPIENS Folate metabolism CSF1 RELA SHMT1 PLAT CRP IL2 IFNG CCL2 SCARB1 HEL-S-44 LDLR HBB HBA2 IL4 MTHFS MPO MAT1A MTHFD1 APOB MTHFD2 SERPINA3 SLC46A1 FLAD1 FGA MTRR IZUMO1R F7 SAA4 PLG INSR CBS MTR SLC19A1 HEL-S-78p ALB SAA1 SAA2 FOLR3 FOLR2 FOLR1 HEL-S-51e IL1B F2 NFKB1 DHFR ABCA1 TNF GPX4 IL6 GPX2 GPX1 GPX3 GPX6 NFKB2 CTH INS IL1 SIGNALING%WIKIPATHWAYS_20260510%WP195%HOMO SAPIENS IL1 signaling MAP2K3 NFKBIB RELA PRKCZ REL MAPKAPK2 HEL-S-71 MAPK9 HSPB2-C11orf52 MAPK8 MAP3K2 IL1R1 IL1A PELI1 PLCG1 TAB3 MAPK3 UBE2V1 SQSTM1 IKBKB IL1B NFKBIA MAP3K1 CHUK TRAF6 MAPK1 MAPK14 IKBKG IRAK4 MAP3K14 NFKB1 MAP2K6 ECSIT MAP2K2 PIK3R2 PIK3R1 MYD88 PTPN11 MAP2K4 JUN MAP3K7 IRAK2 IRAK3 MAP3K7IP1 ATF2 MAP2K1 IRAK1 STEROID HORMONE PRECURSOR BIOSYNTHESIS%WIKIPATHWAYS_20260510%WP5277%HOMO SAPIENS Steroid hormone precursor biosynthesis CYP21A2 SRD5A2 AKR1C1 HSD3B2 HSD3B1 CYP11A1 AKR1D1 CYP17A1 PHYSIOLOGICAL AND PATHOLOGICAL HYPERTROPHY OF THE HEART%WIKIPATHWAYS_20260510%WP1528%HOMO SAPIENS Physiological and pathological hypertrophy of the heart CALM1 MAP2K3 STAT3 MAPK11 MAPK8 EDN1 JUN PRKCB PRKCE CTF1 MYEF2 NFATC4 IL6ST CAMK2D MAPK14 MAPK1 RAC1 PPP3CA GATA4 ARHA FOS HIPPOCAMPAL SYNAPTOGENESIS AND NEUROGENESIS%WIKIPATHWAYS_20260510%WP5231%HOMO SAPIENS Hippocampal synaptogenesis and neurogenesis CREB1 BCL2 CALM1 BDNF PRL RPS6KA1 DRD1 NCAM1 NGF HNRNPL PRKCA RPS6KA5 CAMK4 SYT2 NRXN1 NRXN3 MAPK14 MAPK1 NRXN2 CAMK2A CAMKK1 CAMKK2 CCND2 PPARGC1A LDL INFLUENCE ON CD14 AND TLR4%WIKIPATHWAYS_20260510%WP5272%HOMO SAPIENS LDL influence on CD14 and TLR4 CREB1 CCL2 MAPK12 TLR4 RELB MAPK11 IL6 RELA REL IL10 CREB3L3 NFKB2 CREB3L4 IL1B CREB3L2 CD14 CREB3 MAPK14 NFKB1 MAPK13 CREB5 ATF4 CARNOSINE METABOLISM OF GLIAL CELLS%WIKIPATHWAYS_20260510%WP5313%HOMO SAPIENS Carnosine metabolism of glial cells SLC15A2 CARNS1 SLC15A4 VITAMIN D IN INFLAMMATORY DISEASES%WIKIPATHWAYS_20260510%WP4482%HOMO SAPIENS Vitamin D in inflammatory diseases PPP3R1 MED14 MAP2K3 TNF IL6 RXRA RELA NR3C1 NFATC1 IKBKB NFKBIA MAP3K1 CHUK MAPK14 IKBKG SMAD4 PPP3CA NFKB1 MAP2K6 NR1i1 HEROIN METABOLISM%WIKIPATHWAYS_20260510%WP2645%HOMO SAPIENS Heroin metabolism BCHE CES2 CES1 THERMOGENESIS%WIKIPATHWAYS_20260510%WP4321%HOMO SAPIENS Thermogenesis RPS6KA3 CREB1 MAP2K3 MAPK12 PRKAA2 MAPK11 RPS6 RPTOR CNR1 RPS6KB1 RPS6KB2 MAPK14 CPT1A GNAS MLST8 HRAS ACTG1 TSC2 TSC1 PRKACG CPT2 AKT1S1 SOS1 ACSL1 SOS2 FACL4 ADRB3 ACSL3 SMARCD1 SLC25A20 SMARCD2 SMARCD3 FGF21 ATF2 ADCY3 DPF1 ADCY1 ADCY8 DPF3 SMARCE1 GCG ADCY6 SMARCC1 SMARCC2 MTOR ACTL6B RHEB PS1TP5BP1 ACTL6A KRAS ARID1A GRB2 ARID1B PPARG SMARCA4 CREB3L3 FGFR1 CREB3L4 CREB3L2 PRKAB2 CREB3 PRKAB1 ACSL6 CREB5 MAPK13 ACSL5 SIRT6 PRDM16 NRAS LIPE RPS6KA6 RPS6KA2 RPS6KA1 PRKAG1 PRKG1 PRKAG2 FRS2 PRKAG3 CPT1C PRKAA1 ZNF516 PLIN1 MGLL KDM3A KDM3B UCP1 HEL-S-7a SLC25A29 BMP8A BMP8B PNPLA2 KDM1A MAP3K5 ADCY9 PPARGC1A NUCLEAR RECEPTORS%WIKIPATHWAYS_20260510%WP170%HOMO SAPIENS Nuclear receptors NR1B3 THRA NR5A2 ESRRA RARB NR5A1 NR3C1 PPARG RORC NR2F6 RORA NR1C2 NR3A2 PGR NR1H3 NR1C1 NR1i1 RXRA NR2F2 RARA NR2E1 NR1A2 NR2A1 ROR1 NR2C2 RXRB RXRG NR1i2 ESRRB NR1I3 NR1H2 NR2F1 NR1D2 NR0B1 AKT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260510%WP5531%HOMO SAPIENS AKT signaling and ARTD family members PHLPP1 PARP3 MTOR PARP2 PIK3CD RPTOR IKBKG AKT3 MLST8 STK11 PIK3R3 PIK3R2 PIK3R1 TSC2 TSC1 SIRT1 MAPKAP1 RICTOR GSK3B PIK3CA ATM FOXO1 PIK3R4 PIK3C2G PIK3C2A PARP1 PIK3C2B PIK3R5 NEPHROTOXCICITY ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260510%WP5229%HOMO SAPIENS Nephrotoxcicity adverse outcome pathway SLC31A1 SLC22A2 GASTRIC ACID PRODUCTION%WIKIPATHWAYS_20260510%WP2596%HOMO SAPIENS Gastric acid production CBLIF VIP SCT CCK PGA3 PGC PGA5 GAS MUC6 T CELL ANTIGEN RECEPTOR TCR PATHWAY DURING STAPHYLOCOCCUS AUREUS INFECTION%WIKIPATHWAYS_20260510%WP3863%HOMO SAPIENS T cell antigen receptor TCR pathway during Staphylococcus aureus infection ZAP70 CSF2 MAPK9 GRAP2 DAG1 CHP1 IL10 MAP3K8 PLCG1 AHSA1 MAPK3 LCP2 CARD11 BCL10 ICOS CD40LG CD3D IL2 MAP2K2 IFNG CALM1 LCK PTPRC SOS1 NCK1 IL4 JUN PIK3CA LAT CBL ITK NFATC2 CD8A CTLA4 FYN PTPN6 PDCD1 GRB2 CDK4 IKBKB NFKBIA CHUK RRAS IKBKG RAF1 MAP3K14 NFKB1 TNF PAK1 GSK3B MAP3K7 MAP2K1 IL5 FOS PRKCQ TROP2 REGULATORY SIGNALING%WIKIPATHWAYS_20260510%WP5300%HOMO SAPIENS TROP2 regulatory signaling CHEK1 PAK4 ITGB1 CDKN2A CDK4 PTEN STAT1 IGF1R ACVRL1 PSEN2 HEL113 CCND1 TACSTD2 MDK RAC1 ABCC1 IGF2 NFKB1 IGF2R CLDN7 PECAM1 TLN1 CDK2 BCL2 CTNNB1 PIK3R1 NOTCH1 JUN BAX SRC CDKN1B PRKCA CCNE1 RB1 EGFR CLDN1 IGF1 MIRNA REGULATION OF P53 PATHWAY IN PROSTATE CANCER%WIKIPATHWAYS_20260510%WP3982%HOMO SAPIENS miRNA regulation of p53 pathway in prostate cancer EI24 APAF1 SIAH1 SHISA5 TNFRSF10B BBC3 CYS1 TP53AIP1 CASP8 SESN3 ZMAT3 PERP MDM2 PMAIP1 BAX PTEN CASP9 CASP3 ATM DDB2 CHEK2 DISORDERS OF NAD METABOLISM%WIKIPATHWAYS_20260510%WP5506%HOMO SAPIENS Disorders of NAD metabolism BST1 NAXE NAXD NADSYN1 DNAJB1 PRKACA FUSION IN FIBROLAMELLAR LIVER CANCER%WIKIPATHWAYS_20260510%WP5514%HOMO SAPIENS DNAJB1 PRKACA fusion in fibrolamellar liver cancer CREB1 SIK3 SIK1 SIK2 GNAS DNAJB1 HDAC5 CRTC2 HDAC7 EFFECTS OF NITRIC OXIDE%WIKIPATHWAYS_20260510%WP1995%HOMO SAPIENS Effects of nitric oxide MB AOX1 XDH NOS2 HBB HBA2 NON SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260510%WP4255%HOMO SAPIENS Non small cell lung cancer RARB CASP8 JAK3 CDKN1A PLCG2 FOXO3A PLCG1 MAPK3 STAT5B PIK3CD BRAF CCND1 AKT3 CYCS HRAS MAP2K2 RXRA SOS1 SOS2 MET PDPK1 PIK3CA ALK RB1 HEL-S-61 EGFR EML4 CRABP2 CRABP1 TGFA STK4 FHIT EGF STAT3 HGF CDKN2A KRAS GRB2 CDK6 CDK4 ARAF KIF5A MAPK1 RASSF1 RAF1 POLK DDB2 NRAS E2F2 E2F3 BAK1 GADD45B BAD GADD45A GADD45G RET BAX CASP9 PRKCB PRKCA CASP3 RXRB RXRG MAP2K1 ERBB2 COMPLEMENT ACTIVATION%WIKIPATHWAYS_20260510%WP545%HOMO SAPIENS Complement activation C1R CFP C4B_2 C2 C6 C7 C9 C1QA MASP2 MASP1 CD55 CFD HEL-S-62p C1QB C8A C1S C4A C1QC C8G IL4 SIGNALING%WIKIPATHWAYS_20260510%WP395%HOMO SAPIENS IL4 signaling INPP5D EP300 STAT3 GAB2 MAPK11 PTPN6 IL2RG RELA JAK3 GRB2 MAPK3 JAK1 IKBKB STAT5B PIK3CD NFKBIA STAT1 CHUK RPS6KB1 MAPK1 MAPK14 SOCS1 NFKB1 TYK2 CEBPA PIK3R2 CEBPB PIK3R1 SOCS3 BAD PTPN11 SOS1 IL4 PIK3CA SHC1 IRS1 ATF2 CBL FLNA SOCS5 FOS FES TAR SYNDROME%WIKIPATHWAYS_20260510%WP5362%HOMO SAPIENS TAR syndrome POLR3GL FLT3 POLR3C HLA-G POLR3F POLR3G CD3D CXCR4 IFNG LCK FARP2 MET HDAC2 HLA-A EGFR ANKRD35 EIF4A3 GPR89B STAT3 CCAR2 ITGB1 SLK SUMO2 MAGOH SLC34A3 NUDT17 HEL-S-76p HLA-B HLA-C HFE2 HLA-F HLA-E RBCK1 CFTR SLC22A4 PEX11B FURIN TXN AKAP10 CLCN3 BCL2L13 TNFRSF14 ZFHX3 PEX19 NHERF1 UBE2I PYM1 PDZK1IP1 NFKB1 MITD1 DDIT4 SIRT1 CD160 LAMTOR1 HAMP SYNTHESIS OF CERAMIDES AND 1 DEOXYCERAMIDES%WIKIPATHWAYS_20260510%WP5194%HOMO SAPIENS Synthesis of ceramides and 1 deoxyceramides B4GALT1 CERK SGMS1 SPHK1 SGMS2 DGAT1 UGT8 UGCG B3GNT5 B4GALNT1 KDSR A4GALT A3GALT2 CERS1 tmp_locus_29 CERS2 SPTLC1 CERS3 CERS5 CERS6 GENES TARGETED BY MIRNAS IN ADIPOCYTES%WIKIPATHWAYS_20260510%WP1992%HOMO SAPIENS Genes targeted by miRNAs in adipocytes HAND2 KCNJ2 HCN2 GJA1 ERG TMSB4X IGF1 HCN4 KCNE1 ANDROGEN RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP138%HOMO SAPIENS Androgen receptor signaling NCOR1 CREB1 ZNF318 EP300 FKBP4 RNF6 RNF4 HEL-S-67p RELA BAG1 PATZ1 LIMK2 NR0B2 STUB1 SMIM40 RLN1 RAD9A PTEN CREBBP NCOA1 CCND1 SMAD4 ARHA SP1 CTNNB1 JUN SRC HDAC1 RB1 EGFR FOXO1 ETV5 KAT5 FLNA PAK6 HEL-S-99n SMARCE1 STAT3 BRCA1 SIN3A MDM2 RUNX2 CARM1 PSMC3IP UBE2I RAC1 ROCK1 ROCK2 RHOB CDC42 PIK3R2 PIK3R1 SIRT1 GSK3B NCOR2 TGFB1I1 FHL2 UBE3A CCNE1 KDM1A EFCAB6 SUMO1 RAN ZMIZ1 HEL32 NR2C2 KAT7 TGIF1 PIAS2 PIAS1 TLE5 KAT2B MTHFR DEFICIENCY%WIKIPATHWAYS_20260510%WP4288%HOMO SAPIENS MTHFR deficiency PEMT CHKA EHMT1 HEL-S-61p MARS1 ASMT ALDH7A1 CASP9 CASP3 GRIN1 CHDH DNMT3B CYCS FLT3 P GLN640SERFSTER8 SIGNALING%WIKIPATHWAYS_20260510%WP5431%HOMO SAPIENS FLT3 p Gln640SerfsTer8 signaling FLT3 STAT3 CCR5 CCR6 DEVELOPMENT OF PULMONARY DENDRITIC CELLS AND MACROPHAGE SUBSETS%WIKIPATHWAYS_20260510%WP3892%HOMO SAPIENS Development of pulmonary dendritic cells and macrophage subsets STAT3 CSF2 CSF1 IRF4 TCF4 RUNX2 BATF3 SPI1 FLT3LG IKZF1 TPO ID2 IRF8 CYTOKINES AND INFLAMMATORY RESPONSE%WIKIPATHWAYS_20260510%WP530%HOMO SAPIENS Cytokines and inflammatory response CSF3 CSF2 CSF1 IL7 PDGFA IL13 IL12B IL10 IL1A IL15 TGFB1 IL1B IL11 CXCL1 HLA-DRA IL2 CXCL2 IFNG TNF IL3 IL6 IFNB1 IL4 HLA-DRB1 IL5 11P11 2 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260510%WP5348%HOMO SAPIENS 11p11 2 copy number variation syndrome REST ITGB1 SHH ITGA4 TIMP1 NRXN1 HLA-DRA LGALS3BP IGSF8 CD151 CD82 SPPL2C PRDM11 ACCS PHF21A ALKBH3 SDCBP C11orf96 HLA-DMB CD19 MS4A1 ALX4 TP53I11 LARGE2 HLA-DMA PEX16 CHST6 IZUMO1 SLC35C1 SYT13 MAPK8IP1 EXT1 VANGL1 EXT2 FREY1 SLC25A17 LEF1 B4GAT1 B3GNT7 PEX3 TSPAN18 CHST1 HBEGF CD63 ITGA6 B4GALT4 GLI3 CRY2 TYPE I INTERFERON INDUCTION AND SIGNALING DURING SARS COV 2 INFECTION%WIKIPATHWAYS_20260510%WP4868%HOMO SAPIENS Type I interferon induction and signaling during SARS CoV 2 infection IRF9 IKBKE IRF3 TLR4 IRF7 TLR7 TLR3 RIGI JAK1 STAT1 TRAF6 IRAK4 TYK2 IFNAR2 ACE2 MAVS TRAF3 IFNAR1 MYD88 STAT2 TMPRSS2 EIF2AK2 OAS1 OAS2 IFIH1 TREML4 TBK1 TLR9 ROS IN COVID 19 ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260510%WP5258%HOMO SAPIENS ROS in COVID 19 endothelial dysfunction TNF ACE2 IFNA1 IFNAR1 TNFRSF1A NFKB1 BRAIN DERIVED NEUROTROPHIC FACTOR BDNF SIGNALING%WIKIPATHWAYS_20260510%WP2380%HOMO SAPIENS Brain derived neurotrophic factor BDNF signaling CREB1 RASGRF1 TIAM1 MAP2K5 PRKAA2 RELA MAPK9 MAPK8 PLCG1 MAPK3 CNR1 MAPK14 YBX1 PPP2CA CTNNB1 JUN HEL-S-15 NFATC4 MEF2C IKBKB NFKBIA MAP3K1 CHUK TRAF6 MAPK1 IKBKG RAF1 NFKB1 CDC42 GRIA2 NGF RAP1A GRIN2B IRS1 GRIN1 ADAM17 RPS6KA3 SH2B2 GRIP1 NCF1 NCF2 FOXO3A STAT5B VAV3 STAT1 RPS6 RPS6KB1 ACACB HRAS MAP2K2 KSR1 TSC2 NCK2 NCK1 PDPK1 SHC1 SRC SORT1 SHC4 SHC3 CAMK2A NTRK1 NGFR EIF4EBP1 NTRK2 CRTC1 CDH2 STAT3 SIRPA MAPK10 CDKL5 FYN MTOR CSNK2A1 FRS3 APC DOK5 KCNN2 RANBP9 GRIA3 NCAM1 EIF2S2 EEF2 GRB2 EIF2S1 CDK5 VAV2 MAP3K2 DOCK3 PTPRF SYN1 SQSTM1 KCNA3 MAPK7 NTF3 RPS6KA5 IGF2BP1 PTK2B SH2B1 CAMK4 LINGO1 KIDINS220 NTRK3 CAMK1 ARHG RAC1 MARCKS CDK5R1 SHC2 PIK3R2 BDNF PIK3R1 GABRB3 RPS6KA1 FRS2 PRKAA1 BAD PTPN11 GSK3B EIF4E CASP3 MAP2K1 CYFIP1 UREA CYCLE AND METABOLISM OF AMINO GROUPS%WIKIPATHWAYS_20260510%WP497%HOMO SAPIENS Urea cycle and metabolism of amino groups ASL NAGS ALDH18A1 HEL-S-5 HEL-S-20 HEL-S-29 GLUD1 ARG2 OTC ARG1 ASS1 SRM SMS NEPHROGENESIS%WIKIPATHWAYS_20260510%WP5052%HOMO SAPIENS Nephrogenesis OSR1 FGF8 GREB1L TCF21 PAX2 MEIS1 NOTCH2 WNT9B SIX2 ALDH1A2 RSPO3 RSPO1 FOXD1 WNT4 FGF20 WNT3A BMP7 EIF5A REGULATION IN RESPONSE TO INHIBITION OF THE NUCLEAR EXPORT SYSTEM%WIKIPATHWAYS_20260510%WP3302%HOMO SAPIENS eIF5A regulation in response to inhibition of the nuclear export system IGF2BP1 EIF5A XPO4 KISSPEPTIN KISSPEPTIN RECEPTOR SYSTEM IN THE OVARY%WIKIPATHWAYS_20260510%WP4871%HOMO SAPIENS Kisspeptin kisspeptin receptor system in the ovary FSHR KRAS CYP11A1 PLCB1 MAPK3 PIK3CD HSD3B1 MAPK1 RAF1 PLCB2 NFKB1 MMP9 HRAS STAR MAP2K2 NRAS PLCB4 ARRB2 KISS1R KISS1 GDF9 PRKCH PLCB3 PIK3CA PRKCB PRKCE PRKCA MAP2K1 BMP15 AMH PRKCQ CONGENITAL GENERALIZED LIPODYSTROPHY%WIKIPATHWAYS_20260510%WP5101%HOMO SAPIENS Congenital generalized lipodystrophy FYN DGAT1 HIF1A GRB2 DGAT2 CAVIN1 PIK3CA ITGB4 BSCL2 HMFN0839 LPIN2 LPIN3 LPIN1 IRS1 INS SELECTIVE EXPRESSION OF CHEMOKINE RECEPTORS DURING T CELL POLARIZATION%WIKIPATHWAYS_20260510%WP4494%HOMO SAPIENS Selective expression of chemokine receptors during T cell polarization CCL3 CCR1 IFNG CSF2 CCR7 CCR4 CCR2 IL12B IL4 IL12A TGFB1 CCR5 CD40LG IFNGR2 CXCR4 IL2 IL18R1 IFNGR1 IL5 IL12RB1 CXCR3 CCL4 CCR3 UROTENSIN II MEDIATED SIGNALING%WIKIPATHWAYS_20260510%WP5158%HOMO SAPIENS Urotensin II mediated signaling EP300 RELA HMOX1 GSK3A NCF1 MAPK9 NCF2 MAPK8 NCF4 MAPK3 PTEN CREBBP TGFB1 CYBB CYBA MAPK14 SMAD2 CDC2 ARHA HDAC5 CDK2 BCL2 CTNNB1 VCAM1 ESPL1 PCNA ALOX5 DDIT3 EGFR CAMK2A STAT3 IRF3 PLN IKBKB IL1B CHUK MAPK1 AGTR1 MMP2 NFKB1 MMP9 ABCA1 TNF IL6 UTS2R PTPN11 GSK3B COL1A1 BAX COL3A1 CASP9 COL2A1 CCNE1 UTS2 CASP3 NPPB AIFM2 NPPA TRPC4 ACTA2 HSPA2 NOX4 PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20260510%WP98%HOMO SAPIENS Prostaglandin synthesis and regulation HSD11B1 HSD11B2 EDNRA PRL EDNRB PTGFRN HEL-S-7 S100A10 ANXA1 PTGIS ANXA2 ANXA3 ANXA4 AKR1C2 SCGB1A1 CYP11A1 S100A6 PPARG PTGES AKR1C1 PPARGC1B PTGDR PTGER4 HPGD PTGS2 SOX9 PTGFR ANXA6 PTGS1 PTGIR PTGER1 PTGER2 EDN1 PTGER3 TBXA2R PPARGC1A AKR1B1 EVOLOCUMAB MECHANISM TO REDUCE LDL CHOLESTEROL%WIKIPATHWAYS_20260510%WP3408%HOMO SAPIENS Evolocumab mechanism to reduce LDL cholesterol PCSK9 LDLR AMPK REGULATION OF MAMMARY MILK PROTEIN SYNTHESIS%WIKIPATHWAYS_20260510%WP5492%HOMO SAPIENS AMPK regulation of mammary milk protein synthesis TSC2 MTOR PRKAA2 PRKAG1 PRKAG2 EEF2K PRKAA1 PRKAG3 EEF2 EIF4A2 CSN3 EIF4E CSN1S1 EIF4G1 CSN2 PRKAB2 RPTOR RPS6KB1 PRKAB1 MLST8 DISORDERS OF GALACTOSE METABOLISM %WIKIPATHWAYS_20260510%WP5173%HOMO SAPIENS Disorders of galactose metabolism SLC2A2 SLC5A1 GYS2 HEL-S-19 GYS1 PYGL GYG1 AKR1B1 GLYCINE METABOLISM%WIKIPATHWAYS_20260510%WP1495%HOMO SAPIENS Glycine metabolism HEL-S-51e SHMT1 DNA IR DAMAGE AND CELLULAR RESPONSE VIA ATR%WIKIPATHWAYS_20260510%WP4016%HOMO SAPIENS DNA IR damage and cellular response via ATR CHEK1 MRE11A NBN BRCA2 BCL6 XPA CLK2 RAD9A PRKDC DCLRE1A SMARCAL1 MDC1 FEN1 UBE2D3 CEP164 PLK1 FOXM1 RNF8 HERC2 CDC2 UIMC1 TOPBP1 SP1 RECQL HUS1 CDK2 FANCD2 ATR EEF1E1 MCPH1 ABRAXAS1 SMC1A BRCC3 PPM1D BRIP1 RBBP8 USP1 FANCA CLSPN TP53BP1 ATRIP POLN XRCC5 SHFM1 PALB2 MCM2 TDP1 RAD17 PCNA RAD1 RMI1 TOP3A CDC45 PML SMARCC2 BRCA1 MSH2 MDM2 RECQL4 WRN BARD1 IKBKG RPA1 RFWD3 H2AX RAD52 TRIM28 ATM PARP1 RAD50 CHEK2 RAD51 CANCER PATHWAYS%WIKIPATHWAYS_20260510%WP5434%HOMO SAPIENS Cancer pathways RELA MAPK9 MAPK8 PLCG2 JAG2 PLCG1 DLL3 MAPK3 DLL4 TGFB1 JUP BRAF IL2 ARHA SP1 BCL2 CTNNB1 PLCB4 JUN PIK3CA VEGFC IFNA1 FH IL13RA1 CDKN1A IL15RA FLT3 FLT4 IL15 PTEN PIK3CD NR1C2 IGF1R NR3A2 CCND1 CXCR4 MYC AKT3 HRAS IL6R PDGFRA MAP2K2 IL3 AXIN2 CXCL12 IL2RB KIT CTBP1 RARA SOS1 FRAT1 SOS2 DVL1 MET DVL2 CSF1R DVL3 TCF7L2 PIM1 PIM2 LEF1 LRP5 AXIN1 EGFR FOXO1 LRP6 WNT1 RUNX1T1 NTRK1 ZBTB16 STAT3 PML MTOR APC MDM2 KRAS GRB2 FGFR4 FGFR3 FGFR2 FGFR1 CALML6 ARAF CALML3 CALML4 RASSF1 RAC1 POLK MMP2 DAPK2 DDB2 PIK3R3 PIK3R2 PIK3R1 NRAS E2F2 E2F3 BAK1 GADD45B BAD GADD45A GADD45G BAX CCND3 CDKN1B CCNE1 CCND2 RAD51 EP300 SKP2 BRCA2 SKP1 RBX1 CCNE2 SMAD2 SMAD4 CDK2 CCNA2 HDAC2 HDAC1 LAMC1 CDKN2B MSH6 CCDC6 VHL PTGS2 RET ERBB2 APAF1 BBC3 CASP8 BCL2L11 TNFSF6 FADD BCL2L1 IL5RA IL13 CSF2RB PLCB1 JAK1 CREBBP STAT5B STAT1 IL6ST RPS6KB1 RPS6KB2 STAT4 IL12RB1 EPO EPOR KITLG IL3RA RXRA CRKL CRK TGFA CBL EGF MAPK10 ITGB1 LAMA5 PDGFA SHH FZD1 HEL-S-21 BMP4 GNGT2 KEAP1 TGFBR2 GNG10 BIRC2 NOTCH2 NOTCH1 TERT VEGFA NFKB2 NFE2L2 RXRB RXRG RARB IL2RG JAK3 IGF2 F2R ALK EML4 IGF1 IL7 WNT2B FZD10 WNT5B WNT9B WNT9A WNT16 BDKRB2 BDKRB1 RAC3 APC2 WNT8A WNT8B WNT3 WNT10B F2 WNT10A FZD3 FZD2 FZD5 ARHGEF1 FZD4 WNT3A WNT7B ROCK1 FZD7 ROCK2 FZD9 VEGFB WNT7A FZD8 GNA13 EGLN1 EGLN3 EGLN2 ELOC BIRC7 FLT3LG IFNGR1 TGFBR1 RUNX1 IFNG IL23A HIF1A IL4 IL2RA ITGA6 ITGAV NOS2 COL4A2 BIRC5 SPI1 BIRC3 HEL-S-125m RPS6KA5 ITGA2 CEBPA CTNNA1 EVI1 PMAIP1 EDN1 GSTM2 GSTM1 GSTT2 IFNGR2 GSTA5 IL5 EDNRA EDNRB MGST1 IL12B HES1 IL12A NCOA1 NQO1 PRKACG BMP2 WNT4 TFG KPG_010 RB1 BCR CTBP2 GSTM4 GSTM3 IF1AA9 GLI3 GSTM5 HEY2 APPL1 PAX8 CSF3R ITGA2B IFNA13 IFNA14 IFNA16 TPM3 IFNA17 MSH3 CDKN2A IFNA10 NOTCH3 PTCH1 MAX KNG1 TPR PPARG IFNA21 CDK6 HSP90AB1 SMO NKX3-1 CDK4 PLEKHG5 TRAF1 IKBKB TRAF4 CCDC42 NFKBIA HHIP CHUK FRAT2 MGST3 TRAF6 MGST2 LPAR2 MAPK1 IKBKG LPAR3 LPAR4 RAF1 GSTT2B NFKB1 IFNA4 IFNA7 IFNA6 IFNA2 IFNA8 IFNAR2 SUFU KIF7 TRAF2 CTNNA3 CTNNA2 TRAF5 ARNT2 VEGFD IFNAR1 GSTA4 GSTA3 F2RL3 RALBP1 COL4A1 COL4A4 COL4A3 COL4A6 STAT2 COL4A5 CSF2RA RASGRP4 PRKCB PLD2 RASGRP3 PRKCA PTCH2 IL7R LAMC2 CKS1B ARHGEF11 ARHGEF12 ADCY9 DCC MMP3 HEL-S-22 RALA RALB LAMA1 LAMA4 LAMA3 HES5 LAMB3 LAMB2 LAMB4 LAMB1 HMOX1 GNG12 GNG11 GNG13 GNB2 FAS GNB1 GNAS CYCS GNB4 GNB3 GNB5 GNGT1 PLCB3 CAMK2D CAMK2A GNAI3 ADCY3 ADCY1 ADCY8 GNAI1 ADCY6 GNG3 TCF7L1 GNG2 HGF GNG5 MSH2 GNG4 GNG7 GNA11 KLK3 GNG8 CAMK2G AGTR1 PLCB2 IL6 TRAF3 PTGER4 TXNRD3 PTGER1 TXNRD2 PTGER2 GSK3B PTGER3 CXCL8 LPAR1 CASP9 CASP3 MAP2K1 FOS WNT SIGNALING%WIKIPATHWAYS_20260510%WP428%HOMO SAPIENS Wnt signaling MAPK9 MAPK8 FOSL1 ARHA CTNNB1 PLCB4 DKK1 SFRP1 JUN WNT4 NFATC3 NFATC4 CTBP2 WNT2B FZD10 WNT5B WNT16 SFRP4 WNT3 WNT10B WNT10A FRAT2 FZD3 FZD2 FZD5 WNT3A WNT7B FZD7 ROCK2 FZD9 WNT7A FZD8 PRKCB MAP3K7 PRKCA SOX17 CER1 CSNK2A3 CSNK2A2 CTNNBIP1 DKK2 DAAM1 DAAM2 SFRP5 PLCB1 CSNK2B PORCN PPP3R2 INVS CHD8 SOST KREMEN1 SENP2 CCND1 PRICKLE2 CXXC4 MYC NKD1 PPP3CA NKD2 WIF1 GPC4 NOTUM CTBP1 NLK FRAT1 NFATC1 DVL1 DVL2 VANGL1 DVL3 PLCB3 TCF7L2 LEF1 RYK AXIN1 LRP5 CSNK1E CAMK2D ROR1 ROR2 LRP6 WNT1 CAMK2A CSNK1A1 NFATC2 TCF7L1 CSNK2A1 APC FZD1 CAMK2G PPP3CC RAC1 PLCB2 DKK4 PPP3R1 GSK3B CCND3 CCND2 NICOTINE EFFECT ON DOPAMINERGIC NEURONS%WIKIPATHWAYS_20260510%WP1602%HOMO SAPIENS Nicotine effect on dopaminergic neurons KCNK9 CHRNA5 GNAI1 DDC CHRNA6 TH PPP1R1B SLC18A2 GNG2 DRD4 KCNK3 DRD2 DRD3 CHRNB2 CDK5 GNB1 CHRNA3 TGF BETA RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP560%HOMO SAPIENS TGF beta receptor signaling EP300 MAPK9 JAK1 MAPK3 CREBBP TGFB1 STAT1 SMAD2 SMAD4 HRAS TGFBR1 LEFTY1 IFNG CTNNB1 ZFYVE9 ITGB6 SMAD1 NOG SMAD9 FOXH1 RUNX3 ENG FST LTBP1 SKIL DKFZp781O1323 LIF LEFTY2 JUN SMAD6 SKI BAMBI LEF1 WNT1 EGF STAT3 TGFBR3 INHBA RUNX2 BMP4 FKBP1A THBS1 NFKB1 TNF TGFBR2 ZNF423 SPP1 ZEB2 TGIF1 FOS REGULATION OF WNT B CATENIN SIGNALING BY SMALL MOLECULE COMPOUNDS%WIKIPATHWAYS_20260510%WP3664%HOMO SAPIENS Regulation of Wnt B catenin signaling by small molecule compounds CTNNB1 TCF4 APC FZD1 SFRP4 GSK3B DVL2 TNKS LEF1 MBOAT1 AXIN1 DKK3 WNT1 FZD7 CSNK1A1 FZD8 MITOCHONDRIAL FATTY ACID OXIDATION DISORDERS%WIKIPATHWAYS_20260510%WP5123%HOMO SAPIENS Mitochondrial fatty acid oxidation disorders CPT2 EHHADH ACADM ACSL1 FACL4 PECR ACSL3 ACADVL SLC22A5 ACSF2 HADHB ACADL SLC25A20 ACADS CPT1A ARYLAMINE METABOLISM%WIKIPATHWAYS_20260510%WP694%HOMO SAPIENS Arylamine metabolism CYP1A2 SULT1A1 NAT2 UGT1A9 SULT1A2 UGT1A4 STEROIDOGENIC PATHWAY%WIKIPATHWAYS_20260510%WP4463%HOMO SAPIENS Steroidogenic pathway HSD17B1 HSD3B1 CYP11A1 STAR CYP17A1 PLEURAL MESOTHELIOMA%WIKIPATHWAYS_20260510%WP5087%HOMO SAPIENS Pleural mesothelioma CREB1 SLC3A2 YAP1 EIF4B MAP2K3 CTHRC1 CSF2 ANGPT4 CSF1 AMOT MOBKL1A MAP2K5 PRKAA2 CSNK1A1L MAPK9 MAPK8 MAPK3 TGFB1 MAPK14 MDK IGF2 FOSL1 FGF2 SP1 BCL2 CTNNB1 ACTG1 FGF7 FGF8 PLCB4 FGF9 JUN PIK3CA FGF20 VEGFC FGF23 FGF22 FGF21 RASSF7 IGF1 FGF14 FGF18 CSF3 FGF13 FGF12 FGF10 WNT2B FZD10 FGF8A WNT5B PS1TP5BP1 WNT16 SFRP4 ITGA1 FGF7B WNT3 WNT10B WNT10A FZD3 FGF7A FZD2 FZD5 WNT3A WNT7B FZD7 FZD9 FGF6B VEGFB WNT7A FZD8 FABP4 FGF5C SETD2 RNF2 SLC7A5 CDKN1A IL10 FLT1 FLT3 ITGA4 FLT4 PTEN FLT3LG PIK3CD ULK1 IGF1R RPTOR DEPTOR CCND1 MYC AKT3 KDR MLST8 CCL5 HRAS CCL4 WWTR1 PDGFRA MAP2K2 CCL2 ANGPT2 TSC2 TSC1 ANGPT1 TTI1 HIF1A CXCL12 AKT1S1 KIT CTBP1 ULK2 FRAT1 SOS1 DVL1 MET EPHA2 DVL2 CSF1R DVL3 RB1CC1 SHC1 TCF7L2 SRC RYK LEF1 AXIN1 LRP5 CSNK1E EGFR ITGB3 ROR1 FOXO1 ROR2 ITGA6 LRP6 WNT1 ITGAV NTRK1 NGFR NTRK2 CSNK1A1 INSR CDH2 MTOR CSNK2A1 APC BRCA1 RHEB MDM2 GRB2 FGFR4 COL4A2 FGFR3 FGFR2 CD44 FGFR1 IL1B MAPK7 NTF3 RPS6KA5 PRKAB2 KIF23 PRKAB1 RASSF1 CDH17 MMP2 DKK4 ITGA2 MMP9 SELE CTNNA1 BDNF MAP3K10 PAK1 PRKAG1 PRKAG2 BAK1 PRKAG3 BAX ITGB4 CCND3 CCNE1 ATM CCND2 ACTA2 CDH11 MAPKAPK2 MAD1L1 EIF4G1 FOXM1 CDK7 CDK2 DKK1 SFRP1 WNT4 CTBP2 LAMC1 ATF2 RBBP4 SETD5 SUZ12 MAP3K11 HMGB1 EED CDKN2A KMT2C MAX MEF2D CDK4 EZH2 MAP3K1 FRAT2 BARD1 SETDB1 CXCL1 MAPK1 RAF1 CXCL5 NFKB1 MAP2K6 CTNNA3 TRAF2 CTNNA2 CTGF VEGFD COL4A1 COL4A4 COL4A3 COL4A6 NGF COL4A5 LAMC2 MMP3 INS LAMA1 RPS6KA3 LAMA4 MCL1 LAMA3 ASXL1 WDR5 BAP1 LAMB3 BBC3 LAMB2 LAMB1 SOX17 CER1 CSNK2A3 CSNK2A2 DKK2 SFRP5 CSNK2B JAK1 PORCN STAT1 CHD8 RPS6 SOST KREMEN1 RPS6KB1 SENP2 RPS6KB2 CXXC4 AGER WIF1 CYCS NOTUM KITLG AREG HEL-S-1 TEAD4 MAP2K4 BTC DDIT3 HBEGF SPARC TGFA RASSF2 RASSF3 RASSF4 EIF4EBP1 RASSF6 PAK6 LGALS9 BTRC PAK4 HCFC1 EGF ATF3 MAPK10 IDO1 ITGB1 TCF7L1 PDGFD LAMA5 PDGFC HGF PDGFA STK38L PHC1 LIMD1 BMI1 FZD1 PRSS23 TEAD2 GABPA MAP3K2 TEAD3 MAP4K1 MAP4K2 MINK1 CIT MMP14 TNNT1 CD47 PIGF VGLL4 NTF4 MAP4K3 IL34 MAD2L1 WWC1 CDH9 ACTG2 CDH8 CDH6 YY1 CDH4 MAP3K6 HMGN1 TNIK DSC3 IL6 EFNA5 RPS6KA1 AJUBA EFNA4 BAG2 CDH24 NLRP3 EFNA1 PRKAA1 MOB1A EFNA3 TERT LIN28B EFNA2 MDM4 GSK3B NF2 VEGFA OGT MCU HEL-S-31 PRB1 PRB2 LATS1 ACTA1 MAP3K5 LATS2 CDH10 CDH12 MAP2K1 CDH15 CDH16 CDH18 PPARGC1A CDH19 UHRF1 OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20260510%WP623%HOMO SAPIENS Oxidative phosphorylation NDUFA11 ATP5G1 COXFA4L2 HEL-S-271 ATP6AP2 NDUFC2 NDUFC1 NDUFS8 NDUFS6 NDUFS5 NDUFS4 NDUFS3 NDUFS1 ND3 ND2 ND5 ND4 ND6 NDUFB8 NDUFB7 NDUFB10 NDUFB6 NDUFB5 NDUFB4 ATP6 NDUFB2 ATP5MC2 ATP5MC3 ATP5J NDUFB1 ATP5H HEL-S-123m NDUFV3 NDUFV2 ATP5MG ATP5MF ATP5ME NDUFA9 DMAC2L NDUFA7 NDUFA6 NDUFA5 ATP5PB NDUFA3 NDUFA2 ND4L ATP5F1D ATP5F1E NDUFAB1 ATP5PO NDUFB9 ND1 NDUFA10 COXFA4 WNT BETA CATENIN SIGNALING INHIBITORS IN CURRENT AND PAST CLINICAL TRIALS%WIKIPATHWAYS_20260510%WP5442%HOMO SAPIENS Wnt Beta catenin signaling inhibitors in current and past clinical trials PORCN CREBBP CTNNB1 LRP5 LRP6 METAPATHWAY BIOTRANSFORMATION PHASE I AND II%WIKIPATHWAYS_20260510%WP702%HOMO SAPIENS Metapathway biotransformation Phase I and II CYP21A2 AKR1C2 MGST1 CYP1B1 CYP11A1 UGT1A4 UGT1A3 UGT1A7 UGT1A1 CYP4F2 CYP4F12 TPMT HEL-S-75 GSTM4 HS6ST1 GSTM3 HS6ST2 HS6ST3 GSTM5 CYP4Z1 NDST3 HEL-S-166mP UGT2B11 UGT2B15 UGT2B17 SULT2B1 CYP2U1 SULT6B1 NNMT HS3ST3A1 CYP4F22 CYP2C18 CYP2B6 CYP4X1 CYP27B1 CHST11 CHST12 CYP24A1 CHST10 CYP17A1 CHST13 CHST14 SULT1A4 NAA50 CYP2J2 GATF-C GLYATL2 MGST3 HEL-S-165mP MGST2 EPHX1 CYP4F3 CYP4F11 CYP4F8 GSTT2B CYP26A1 SULT1B1 CYP27C1 AKR1B10 NAT8 CYP2S1 NAT9 NAA40 NAT10 UGT1A10 NAT14 LOC51064 GPX4 HS2ST1 SULT1C3 GSTA4 SULT1C2 GSTA3 CYP26B1 CYP4V2 CYP3A4 HYAL3 CYP2C19 CYP2R1 UGT2A2 CYP2C9 UGT2A1 CYP2C8 GAL3ST3 CYP1A2 GAL3ST4 SULT1C4 CHST8 HS3ST3B1 CHST9 CHST7 CYP3A43 KCNAB1 KCNAB3 INMT CYP2A7 CYP26C1 HEL-S-22 UGT2B4 CHST4 NAT8L CHST5 UGT2B7 CHST3 HEL-S-75p NAA20 UGT2B28 SULT1E1 CYP2A13 UGT1A5 CYP2F1 GAL3ST2 CYP4B1 HS3ST5 HS3ST6 FMO4 HS3ST4 FMO5 HS3ST1 HS3ST2 GSTZ1 CYP2W1 CYP20A1 CYP7A1 CYP8B1 UGT1A9 CHST6 AKR1D1 AKR1C4 BAAT CYP7B1 CYP27A1 EPHX2 SULT1A1 CHST1 NAT2 SULT1A2 CYP3A7 HEL-S-21 CYP46A1 AKR1C1 CYP11B2 CYP2A6 CYP1A1 CYP2E1 GPX2 GPX3 HEL-S-64p GSTM2 GSTM1 GSTT2 HEL-75 SULT2A1 GSTA5 AKR1B1 CYP51A1 GPCRS CLASS C METABOTROPIC GLUTAMATE PHEROMONE%WIKIPATHWAYS_20260510%WP501%HOMO SAPIENS GPCRs class C metabotropic glutamate pheromone GRM2 GABBR2 GABBR1 CASR GRM3 GPRC5A GRM4 GRM6 GRM8 GPRC5D GPRC5C NEURAL CREST CELL MIGRATION IN CANCER%WIKIPATHWAYS_20260510%WP4565%HOMO SAPIENS Neural crest cell migration in cancer ARF1 EPHB2 PAK4 EPHB1 STAT3 TRIO EPHB4 EPHB3 TIAM1 CDH11 F2RL2 PIK3CD KIDINS220 RAC1 AKT3 MMP2 MMP9 ARHA PIK3R3 BDNF PAK1 JUN PIK3CA SORT1 TWIST1 PIK3R4 NGFR PIK3R5 NTRK2 FOS EPHB6 PAK6 PATHOGENIC ESCHERICHIA COLI INFECTION%WIKIPATHWAYS_20260510%WP2272%HOMO SAPIENS Pathogenic Escherichia coli infection TLR4 ITGB1 WASL FYN PS1TP5BP1 ARPC1B ROCK1 ROCK2 WAS ARHA TUBAL3 LY96 TUBB8 CDC42 TUBA3E ACTG1 TUBA1C CTNNB1 TUBB6 TUBA1B TUBA1A TUBB1 TUBB ARPC4 HEL-68 TUBB4B YWHAQ TUBB4A TUBA4A NCK2 TUBB2A NCK1 KRT18 YWHAZ ARPC2 EZR ARPC3 TUBA2 NCL HCLS1 PRKCA ARHGEF2 TLR5 CD14 TUBA8 CLDN1 ARPC5 CANONICAL AND NON CANONICAL NOTCH SIGNALING%WIKIPATHWAYS_20260510%WP3845%HOMO SAPIENS Canonical and non canonical Notch signaling NOTCH2 NOTCH3 NOTCH1 JAG2 DLL3 HES1 DLL4 LEF1 CHUK RRAS MAML2 PSEN2 ADAM10 PSEN1 RBPJ DLK2 MFAP1 DNER MFAP2 MAML1 MAML3 RIBOFLAVIN AND COQ DISORDERS%WIKIPATHWAYS_20260510%WP5037%HOMO SAPIENS Riboflavin and CoQ disorders SLC52A2 ETFDH SLC52A1 PDSS1 ETFA COQ8A COQ9 APTX COQ7 COQ6 FLAD1 COQ2 DNA DAMAGE RESPONSE ONLY ATM DEPENDENT %WIKIPATHWAYS_20260510%WP710%HOMO SAPIENS DNA damage response only ATM dependent BBC3 BCL6 BCL2L11 TNFSF6 MAPK9 MAPK8 CDKN1A FOXO3A PTEN TGFB1 PIK3CD CCND1 PCK2 G6PC1 MYC SMAD4 AKT3 FOSL1 ARHA HRAS BCL2 CTNNB1 RBL2 LDLR FRAT1 SOS1 SOS2 DVL1 DVL2 JUN PIK3CA DVL3 WNT4 SHC1 TCF7L2 LEF1 AXIN1 WNT1 INSR MAPK10 TCF7L1 WNT2B HMGB1 APC WNT5B CDKN2A MDM2 PPP2R5E KRAS PPP2R5C WNT16 GRB2 MLKL BIK RAC3 CCNG2 TP73 WNT3 WNT10B WNT10A MAP3K1 MAPK1 WNT3A RAC1 WNT7B NFKB1 WNT7A CDC42 PIK3R3 PIK3R2 PIK3R1 NRAS BAK1 BAD PMAIP1 GSK3B BAX NFKB2 CCND3 MAP3K7 CDKN1B ATM IRS1 PIK3R4 PIK3C2G PIK3C2A CCND2 PIK3C2B PIK3R5 ERBB2 MIR TARGETED GENES IN LEUKOCYTES%WIKIPATHWAYS_20260510%WP2003%HOMO SAPIENS miR targeted genes in leukocytes SH3BGRL3 ACP2 NELFCD CTSC SCYL1 SLC7A6 CDCP1 RFT1 FRG1 PTRH1 UNC93B1 ANAPC1 HEL-S-47e POLE4 PTPA SHOC2 CDIPT MAP3K8 CA12 AP3D1 ARCN1 WDR11 FMNL2 MAPK14 SPTLC1 IGF2R BCL2 CTNNB1 PRPF40A LPL USP1 DNAJB1 MTHFD2 FADS1 SRSF10 HEL-S-26 TPM3 ANXA2 CDK6 TYMS KCNN4 LAMTOR3 POLR2C HEL-S-30 GNA13 CEBPB CAP1 MCL1 GYS1 BCL6 SLC7A11 HMOX1 ATP2A2 TUBA1A YWHAQ PPIB HMGA1 SERPINE2 PLXND1 RDH10 TUSC2 ARID4B DCAF7 TXN2 PNP CHORDC1 GOLGA7 CDK5RAP3 THBS1 ARHG VPS39 ATP6V0E1 TNLG5A IFRD1 HEL-S-66 PISD RAB34 PPIF POM121 DDX5 RAB5C SLC1A4 ADIPOR2 RTN4 CORO1C MRPL20 SAC3D1 MPDU1 ATP6V1F SNX6 CD164 PHC2 BRPF3 TBCA MENT SFXN1 SLC25A1 ARF4 TRAM1 TMED10 ADPGK TNFAIP2 ADAR LMNB2 SNAP23 PRSS21 MRC2 TMEM43 TMED3 TMEM109 REGULATORY CIRCUITS OF STAT3 SIGNALING%WIKIPATHWAYS_20260510%WP4538%HOMO SAPIENS Regulatory circuits of STAT3 signaling MAPK12 MAPK11 IL2RG F2RL2 JAK3 IL9R MAPK9 IL5RA MAPK8 CSF2RB IL15RA JAK1 MAPK3 CREBBP PTPRT CNTFR MPL RPTOR IL6ST GHR DEPTOR DUSP2 MAPK14 IL11RA IL27RA OSMR IL20RA IFNGR1 IL20RB MLST8 TYK2 IL10RB IL10RA IL6R IFNLR1 PDGFRA MAPK15 IL22RA1 PTPRC IL3RA SOCS3 AKT1S1 IL2RB F2R IL21R IL2RA SRC EGFR CSF3R STAT3 MAPK10 MTOR SETD7 MAPK7 CTF1 MAPK1 AGTR1 AGTR2 MAPK13 IFNAR2 MAPK6 MAPK4 IFNAR1 F2RL3 MAPKAP1 RICTOR CSF2RA PRKCB TRIM28 IL7R IFNGR2 CATALYTIC CYCLE OF MAMMALIAN FLAVIN CONTAINING MONOOXYGENASES FMOS %WIKIPATHWAYS_20260510%WP688%HOMO SAPIENS Catalytic cycle of mammalian flavin containing monooxygenases FMOs FMO4 FMO5 PATHWAYS AFFECTED IN ADENOID CYSTIC CARCINOMA%WIKIPATHWAYS_20260510%WP3651%HOMO SAPIENS Pathways affected in adenoid cystic carcinoma NCOR1 CHEK1 EP300 BCOR PRKDC FOXO3A PTEN CREBBP MYC HRAS MAP2K2 JMJD1C TLK1 HIST1H1E CMTR2 MAGI1 SMC1A KDM6B FBXW7 HIST1H2AK INSRR ARID5B CTBP1 FOXP2 MORF4L1 MYBL1 KAT6A BCORL1 MYCBP PIK3CA SRCAP DTX4 MGA ERBIN KANSL1 NFIB MAML3 FGF16 SMARCE1 BRCA1 KMT2C MAX ARID1A FGFR4 ARID4B RAF1 CEBPA NOTCH1 ATM SETD2 MYB CHEK2 UHRF1 ERBB2 ANGIOPOIETIN LIKE PROTEIN 8 REGULATORY PATHWAY%WIKIPATHWAYS_20260510%WP3915%HOMO SAPIENS Angiopoietin like protein 8 regulatory pathway MAP2K3 MAP2K5 PRKAA2 MAPK9 MAPK8 MAP3K8 MAPK3 MAPK14 SESN3 LPL PIK3CA SCD IRS4 FASN CBLC RPS6KA4 MLXIPL MAP3K13 MAP3K12 FLOT1 FLOT2 FBP1 PTPN1 THRA HEL-S-42 TRIP10 PCK1 MAP3K11 CYP2B6 MAP3K1 MAPK1 RAF1 MAP3K14 MAP2K6 MAPK13 SLC2A4 MAPK6 CAP1 MAPK4 CYP3A4 MAP3K7 IRS1 PIK3R4 PIK3C2G PIK3C2A INS RPS6KA3 MAPK12 GYS1 MAPK11 SLCO1C1 GSK3A FOXO3A SLC16A2 PIK3CD RPTOR RPS6KB1 RPS6KB2 G6PC1 MLST8 NR1H3 HRAS MAP2K2 CYP7A1 ABCG8 TSC2 ABCG5 TSC1 RXRA ANGPTL8 SOS1 SOS2 MAP2K4 PDPK1 SHC1 CRK FOXO1 SHC3 CBL EIF4EBP1 INSR MAPK10 MTOR RHEB MAP3K2 MAP4K1 MAP4K2 MINK1 RAPGEF1 MAPK7 RPS6KA5 PRKAB2 PRKAB1 MAP4K3 EXOC7 SHC2 PIK3R3 MAP3K6 PIK3R2 PIK3R1 MAP3K10 RPS6KA6 RPS6KA2 RPS6KA1 PRKAG1 PRKAG2 PRKAG3 PRKAA1 MAPKAP1 RICTOR GSK3B SREBF2 EIF4E HEL-S-31 NR1A2 MAP3K5 MAP2K1 CILIARY LANDSCAPE%WIKIPATHWAYS_20260510%WP4352%HOMO SAPIENS Ciliary landscape YAP1 HEL-S-47e TFAP2A HEL113 CTNNB1 MCM7 NDUFA9 MCM3 NDUFA5 MCM5 IQGAP1 MCM6 MCM2 DYNC2I2 HDAC2 ACSL3 HDAC1 TRAF3IP1 SNRPB2 RB1 IFT172 CTBP2 MCM9 IFT52 WEE1 DGKE BBS9 UBE2D2 BBS7 SMC4 H3F3B PSMD7 CEP97 APMAP IFT57 RAB2A DYNC1LI1 IFT56 MYL6 BBS5 TIPRL BBS4 ERF ARL8B PSMD12 DYNLT1 INTU IFT140 PSMD13 HEL-S-296 IFT80 IQGAP3 CDH23 NUP88 LZTFL1 CDR2 AAR2 CTSA IFT43 NEK8 TFAP2C IFT81 UBE2H TFAP2D TFAP2E NFKB1 RHBDD2 EXOC6B CNOT10 IFT46 BBIP1 LSM4 TBC1D4 EHD3 IFT70B CNOT1 WNK1 LCN2 RANBP10 DYNLRB2 DYNLT2B NEF3 DOCK5 ZMYND19 MCM10 IFT74 MYL6B RPGR NEFL CEP170 TMED1 DFNB31 CEP290 NINL SNAP29 IQCB1 EIF5B BBS2 RBM14 BBS1 NUDC CNOT6L EXOC8 NUP133 EIPR1 FUZ DYNLT3 RAB3IL1 RALB ARFGAP3 DYNLL2 IFT20 RABEP2 NME8 TTC8 EXOC4 EXOC3 HTRA2 MKS1 EXOC6 IFT27 EXOC5 EFHC2 MAPRE2 EXOC2 PAFAH1B1 DNCL1 MAEA CCDC40 CLUAP1 GDI1 EXOC1 IFT25 IFT70A ECHS1 HEL-S-91n ARMC8 SSNA1 ANKS3 CREBBP VPS4A USH1C RAB21 RMND5B EXOSC4 DNPEP PGRMC2 STOM UQCC DYNC1H1 COPS7A LRPPRC PSMC6 RAB14 GLB1 PSMC4 CALM1 VAPB XPNPEP3 COPS4 GID8 COPS6 RQCD1 IFT22 YPEL5 COPS5 GLA COPS8 DVL3 RAB8A CAMK2A MFAP1 WDR26 CBS TFAP2B RMND5A APC MSH2 RANBP9 MKLN1 GID4 DCAF7 RAC1 EXOC7 POM121 DDX5 OPIOID RECEPTOR PATHWAYS%WIKIPATHWAYS_20260510%WP5093%HOMO SAPIENS Opioid receptor pathways SPINAL CORD INJURY%WIKIPATHWAYS_20260510%WP2431%HOMO SAPIENS Spinal cord injury TLR4 ANXA1 IL1R1 IL1A MAPK3 TGFB1 HEL113 IL2 PLA2G6 CDC2 ARHA CDK2 LTB4R RB1 E2F5 EGR1 CCR2 CHST11 ROS1 CDK4 CXCL1 MAPK1 CXCL2 ROCK2 CDC42 ACAN GJA1 SOX9 COL4A1 PTGS2 APEX1 COL2A1 PRKCA GRIN1 C1QB FOXO3A CCND1 MYC PPP3CA TNFSF13 IFNG CCL2 XYLT1 AQP4 AQP1 ZFP36 EPHA4 SEMA6A OMG MIF PDYN BCAN IL4 RTN4R PLA2G5 KLK8 EFNB2 PLXNA2 GFAP SELP GDNF EGFR CSPG4 BTG2 NCAN TACR1 RGMA NGFR MMP12 VCAN GAP43 LTB AIF1 NTN1 SLIT1 TNLG7A SLIT3 SLIT2 PLA2G2A LILRB3 FCGR2A NOS2 CCNG1 IL1B CD47 FKBP1A RAC1 ARG1 MMP9 RHOB MBP LEP TNF BDNF IL6 RTN4 GADD45A CXCL8 CDKN1B PRB1 PRB2 CASP3 NOX4 FOS 1P36 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP5345%HOMO SAPIENS 1p36 copy number variation syndrome PEX10 PEX12 HES5 RNF223 OR4F16 MORN1 TMEM278 FNDC10 RBX1 ANKRD65 PRKCZ INTS4 PLCH2 INTS9 VTN AGRN PARD6B SLC35E2B C1orf159 TGFB1 ARF6 SMAD2 SMAD4 GNB1 DVL1 SKI MCM2 DKK3 IFIH1 ELAVL1 PANK4 INTS11 INTS13 INTS14 INTS10 GDE1 TMEM52 GRIK2 CALML6 NOC2L IFIT1 METTL14 TNFRSF14 SDF4 PLEKHN1 CCNL2 TNFRSF4 SAMD11 MUSK TNFRSF18 HEL-S-72p SSU72 TRIM25 PEX2 ATAD3A ATAD3C GLTPD1 TRAF2 ACAP3 RER1 SCNN1D TRAF5 MMP23B C1QTNF12 PEX5 MXRA8 MRPL20 VWA1 AURKAIP1 TNLG2B TNLG2A PERM1 CD160 KLHL17 MEPCE LRP4 VEGFA UBE2J2 PHKG2 BTLA PUSL1 TAS1R3 NADK HES4 COMMD1 OR4F5 OR4F3 CDK11A CFAP74 MIB2 ISG15 B3GALT6 MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY%WIKIPATHWAYS_20260510%WP1544%HOMO SAPIENS MicroRNAs in cardiomyocyte hypertrophy MAP2K3 MAP2K5 CDK9 MAPK8 MYLK3 CISH HDAC9 MAPK3 TGFB1 PIK3CD IGF1R IL6ST MAPK14 PPP3CA ARHA FGF2 HDAC5 CDK7 MYLK MAP2K2 CALM1 CTNNB1 EIF2B5 MAP2K4 DVL1 LIF PDPK1 NRG1 PIK3CA LRP5 NFATC4 CAMK2D LRP6 MAP3K7IP1 GATA4 IGF1 IKBKE EGF STAT3 MTOR PLA2G2A FZD1 HDAC7 FGFR2 IKBKB MAPK7 CTF1 CHUK MYEF2 FZD2 MAPK1 IKBKG WNT3A RAC1 RAF1 ROCK1 PLCB2 ROCK2 MAP3K14 NFKB1 MAP2K6 PIK3R3 TNF PIK3R2 PIK3R1 MAPK4 PRKG1 GSK3B EDN1 PRKCB NPPB NPPA MAP2K1 FATTY ACID TRANSPORTERS%WIKIPATHWAYS_20260510%WP5061%HOMO SAPIENS Fatty acid transporters FABP1 SLC27A4 ACSL1 FABP9 FACL4 FABP5 ACSL3 FABP6 FABP2 ACSL6 ACSL5 CD36 DBI FABP4 SENESCENCE AND AUTOPHAGY IN CANCER%WIKIPATHWAYS_20260510%WP615%HOMO SAPIENS Senescence and autophagy in cancer MAP2K3 CDC25B MAP1LC3C VTN CDKN1A IL1A PLAT PTEN TGFB1 IL24 ING1 IRF1 ULK1 IGF1R LAMP2 DKFZp762B153 SLC39A2 IL6ST SLC39A1 BRAF SLC39A3 SERPINB2 MAPK14 SH3GLB1 TNLG1B SMAD4 IGFBP5 RNASEL MAP1LC3A MLST8 AMBRA1 HRAS IFI16 ATG5 IL6R ATG3 CREG1 ATG10 CCL3 IGFBP7 IFNG UVRAG BCL2 RSL1D1 ATG14 IL3 ATG12 AKT1S1 ATG16L1 BMP2 JUN RB1CC1 SRC PCNA RB1 SPARC CXCL14 IGF1 IRF7 MTOR KMT2A HMGA1 CDKN2A MDM2 BMI1 INHBA SQSTM1 CD44 MMP14 IL1B CXCL1 MAPK1 THBS1 RAF1 CEBPB IL6 COL10A1 GABARAPL2 GABARAPL1 IFNB1 GSK3B CXCL8 COL1A1 COL3A1 CDKN1B GABARAP MAP2K1 INS DISORDERS IN KETOLYSIS%WIKIPATHWAYS_20260510%WP5195%HOMO SAPIENS Disorders in ketolysis BDH1 OXCT1 ACAT2 ACAT1 HMGCS1 AMINO ACID METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260510%WP5213%HOMO SAPIENS Amino acid metabolism in triple negative breast cancer cells SLC7A11 GLS PSAT1 PHGDH PSPH OXYSTEROLS DERIVED FROM CHOLESTEROL%WIKIPATHWAYS_20260510%WP4545%HOMO SAPIENS Oxysterols derived from cholesterol HSD11B1 HSD11B2 SULT2B1 RORC CYP46A1 NR3A2 SLC27A2 IL17B CYP7A1 CYP8B1 DHCR7 IL25 INSIG1 DBP THEM5 HSD3B7 LBP CYP3A4 ACOT9 ACOT8 ACOT7 ACOT11 AKR1D1 ACOT12 ACOT13 AKR1C4 CH25H EBP BAAT GPR183 IL17F IL17D ACOT6 CYP7B1 IL17C IL17A CYP27A1 ACOT4 EPHX2 AMACR SULT2A1 SLC27A5 NR1i2 NR1H2 SYNAPTIC SIGNALING ASSOCIATED WITH AUTISM SPECTRUM DISORDER%WIKIPATHWAYS_20260510%WP4539%HOMO SAPIENS Synaptic signaling associated with autism spectrum disorder MTOR PRKAA2 CACNA1C ARC RHEB KRAS MAPK3 PTEN PIK3CD CAMK4 RPTOR PRKAB2 RPS6KB1 MAPK1 PRKAB1 AKT3 HRAS PIK3R3 PIK3R2 BDNF PIK3R1 TSC2 NRAS TSC1 PRKAG1 PRKAG2 PRKAA1 PRKAG3 GSK3B NF1 SYNGAP1 PIK3CA UBE3A HOMER1 GRIN3B GRIN2B GRIN3A GRIN1 DLG4 SHANK3 EIF4EBP1 NTRK2 WARBURG EFFECT MODULATED BY DEUBIQUITINATING ENZYMES AND THEIR SUBSTRATES%WIKIPATHWAYS_20260510%WP5216%HOMO SAPIENS Warburg effect modulated by deubiquitinating enzymes and their substrates OTUD6B MTOR HIF1A VHL PGAM1 VEGFA PIK3CA U2AF2 OTUB2 FOXO1 USP37 G6PC1 USP44 HEL-S-133P MYC OTUD7B SIRT7 KDR HEL-S-68p USP28 USP19 HK2 FBP1 MALATE ASPARTATE SHUTTLE%WIKIPATHWAYS_20260510%WP4315%HOMO SAPIENS Malate aspartate shuttle SLC1A3 SLC25A11 GOT2 HEL-S-32 DEREGULATION OF RAB AND RAB EFFECTOR GENES IN BLADDER CANCER%WIKIPATHWAYS_20260510%WP2291%HOMO SAPIENS Deregulation of Rab and Rab effector genes in bladder cancer MADD SYTL1 RAB27B MYRIP SYTL5 UNC13D TBC1D10A SYTL2 EXPH5 MLPH RAB27A RPH3A CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260510%WP197%HOMO SAPIENS Cholesterol biosynthesis pathway DHCR7 HMGCS1 HMGCR IDI1 SC5D FDPS MVK MSMO1 SQLE PMVK MVD FDFT1 CYP51A1 MEVALONATE PATHWAY%WIKIPATHWAYS_20260510%WP3963%HOMO SAPIENS Mevalonate pathway HMGCR FDPS MVK ACAT2 PMVK HMGCS1 MVD CHOLESTEROL METABOLISM WITH BLOCH AND KANDUTSCH RUSSELL PATHWAYS%WIKIPATHWAYS_20260510%WP4718%HOMO SAPIENS Cholesterol metabolism with Bloch and Kandutsch Russell pathways ELOVL4 CYP46A1 MSMO1 TM7SF2 ABCG1 NR1H3 LBR SOAT2 ABCA1 MYLIP DHCR7 SOAT1 HMGCS1 ELOVL5 ACSL1 ELOVL2 SREBF2 HSD17B7 CH25H EBP ELOVL3 FACL4 HMGCR IDI1 SC5D ACSL3 FADS2 FDPS CYP27A1 MVK SCD GGPS1 FASN FADS1 ACAT2 DHCR24 SQLE PMVK NR1H2 MVD FDFT1 CYP51A1 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260510%WP4249%HOMO SAPIENS Hedgehog signaling IHH CSNK1A1L SHH PTCH1 BOC CDON CSNK1G3 SMO ADRBK1 SMURF2 SMURF1 FBXL17 GPR161 HHIP SPOPL GAS1 CSNK1G2 CCND1 EVC SUFU BCL2 KIF7 PRKACG ARRB2 DHH KIF3A PTCH2 SPOP EVC2 CSNK1D CSNK1E GLI3 CSNK1G1 CCND2 CSNK1A1 MIR TARGETED GENES IN ADIPOCYTES%WIKIPATHWAYS_20260510%WP2001%HOMO SAPIENS miR targeted genes in adipocytes CEBPB TGFBR2 CAP1 LPL ELOVL5 CYP1B1 PHC2 SRSF9 TMED10 PICALM SRSF10 FADS1 IGF2R TMEM43 ADIPOGENESIS%WIKIPATHWAYS_20260510%WP236%HOMO SAPIENS Adipogenesis CREB1 PTGIS TGFB1 CNTFR NCOA1 CELF1 SOCS1 SP1 CTNNB1 LPL RBL2 RBL1 BMP2 SCD RB1 IRS4 E2F4 GATA4 IGF1 MEF2C MEF2B PCK1 WNT5B SFRP4 PPARG MEF2D WNT10B LMNA CISD1 MBNL1 GTF3A PRLR CYP26A1 ADFP TRIB3 ZMPSTE24 NDN GH1 BMP3 ID3 SLC2A4 CEBPB ASIP SPOCK1 GDF10 OSM KLF7 PNPLA3 CYP26B1 MIXL1 NAMPT STAT2 NCOR2 KLF6 FOXC2 CFD IRS1 TWIST1 INS NCOR1 NR3C1 CDKN1A STAT5B RORA NR1C2 STAT1 AHR IL6ST LPIN1 PCK2 FAS NR1H3 NR1C1 WWTR1 RXRA GATA3 HIF1A SOCS3 RARA MIF BMP1 DVL1 LIF RETN DDIT3 FOXO1 WNT1 GATA2 STAT3 HMGA1 FRZB FZD1 HNF1A BMP4 LEP CEBPA CEBPD TNF LIPE EGR2 IL6 KLF15 KLF5 GADD45B GADD45A PLIN1 UCP1 BSCL2 LPIN2 LPIN3 RXRG NR2F1 PPARGC1A BILE ACID SYNTHESIS AND ENTEROHEPATIC CIRCULATION %WIKIPATHWAYS_20260510%WP4389%HOMO SAPIENS Bile acid synthesis and enterohepatic circulation MAPK3 CYP7A1 ABCG8 ABCB11 ABCG5 FGF8A MAPK1 FXR1 LDLR SLC10A2 FGFR4 EPAC1 AND PKA REDUCTION OF RETINAL INFLAMMATION%WIKIPATHWAYS_20260510%WP5440%HOMO SAPIENS EPAC1 and PKA reduction of retinal inflammation IL1B NLRP3 PRKAR1B PRKAR1A OMEGA 3 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260510%WP5432%HOMO SAPIENS Omega 3 fatty acids in senescence ALOX15 PTGIS CYP3A4 HPGD GPR32 PTGS2 ELOVL5 PTGS1 FPR2 CYP2C9 PTGES ELOVL2 LTC4S CYP2C8 CYP1A2 ALOX15B FADS2 ALOX5 EPHX2 FADS1 GSTM4 ALOX12 HEL-S-22 CYP2E1 CORI CYCLE%WIKIPATHWAYS_20260510%WP1946%HOMO SAPIENS Cori cycle SLC2A2 HEL-S-49 SLC2A4 PFKP HEL-S-87p HEL-S-133P GPT INS PGAM1 HEL-S-68p HEL-S-162eP NANOPARTICLE TRIGGERED AUTOPHAGIC CELL DEATH%WIKIPATHWAYS_20260510%WP2509%HOMO SAPIENS Nanoparticle triggered autophagic cell death ATG10 UVRAG INSR BCL2 TSC2 TSC1 ATG14 ATG12 ATG16L1 ATG9B ULK2 VMP1 CHAF1A ULK1 SH3GLB1 INS AMBRA1 MAP1LC3A ATG5 ATG3 ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20260510%WP554%HOMO SAPIENS ACE inhibitor pathway ACE2 NR3C2 ATP6AP2 KNG1 REN BDKRB2 BDKRB1 MGRA TGFB1 CTSG CMA1 CYP11B2 AGTR1 AGTR2 INFLUENCE OF LAMINOPATHIES ON WNT SIGNALING%WIKIPATHWAYS_20260510%WP4844%HOMO SAPIENS Influence of laminopathies on Wnt signaling HES5 TCF7L1 CSNK1A1L APC PPARG RUNX2 CDK6 HES1 WNT10B LMNA CCND1 ZMPSTE24 CEBPA CEBPD SLC2A4 CTNNB1 CEBPB SPP1 GSK3B TOR1AIP1 FNTA EMD TCF7L2 ICMT LEF1 HMGA2 AXIN1 DICER1 AGO2 TARBP2 CSNK1A1 CONTROL OF IMMUNE TOLERANCE BY VASOACTIVE INTESTINAL PEPTIDE%WIKIPATHWAYS_20260510%WP4484%HOMO SAPIENS Control of immune tolerance by vasoactive intestinal peptide IFNG IL12A TGFB1 CTLA4 VIP CD80 IL2 FAS IL5 IL10 IL4 SPHINGOLIPID METABOLISM INTEGRATED PATHWAY%WIKIPATHWAYS_20260510%WP4726%HOMO SAPIENS Sphingolipid metabolism integrated pathway PLPP2 CERK PLPP1 SGMS1 SPHK1 SGMS2 UGT8 UGCG KDSR CERS1 CERS2 SPHK2 SGPP2 SGPP1 SGPL1 SPTLC2 SPTLC1 SMPD1 CERS3 DEGS1 CERS5 DEGS2 CERS6 PLPP3 VASOPRESSIN REGULATED WATER REABSORPTION%WIKIPATHWAYS_20260510%WP5085%HOMO SAPIENS Vasopressin regulated water reabsorption DYNLL2 CREB1 DCTN6 ADCY6 DCTN5 RAB5B DCTN1 DCTN4 ARHGDIG HEL-S-77 AQP2 DYNC1LI1 ARHGDIB DNCL1 HEL-S-47e STX4A DYNC1I1 DYNC2H1 AVPR2 RAB11A RAB11B DYNC1LI2 CREB3L3 AVP CREB3L4 RAB5A CREB3L2 CREB3 DYNC1H1 GNAS CREB5 RAB5C VAMP2 AQP3 PRKACG AQP4 DYNC2LI1 ADCY9 ADCY3 EFFECT OF DASATINIB ON THE BCR ABL SIGNALING PATHWAY%WIKIPATHWAYS_20260510%WP5493%HOMO SAPIENS Effect of dasatinib on the BCR ABL signaling pathway INPP5D EIF4B GAB2 BCL9 MAPK11 DOK1 KRAS GRB2 HSPB2-C11orf52 MAP3K2 MAPK3 BCLAF1 ARAF VAV1 SPAG1 BRAF MAPK1 MAPK14 RAF1 AKT3 HRAS SHC2 BCL2 PIK3R1 NRAS RPS6KA1 CRKL SOS1 PXN PIK3CA SHC1 SRC BCR CRK SHC4 SHC3 HEL-S-102 ATF2 CBL MEF2C EXRNA MECHANISM OF ACTION AND BIOGENESIS%WIKIPATHWAYS_20260510%WP2805%HOMO SAPIENS exRNA mechanism of action and biogenesis XPO5 DGCR8 DROSHA ERI1 AGO2 DICER1 MONOAMINE GPCRS%WIKIPATHWAYS_20260510%WP58%HOMO SAPIENS Monoamine GPCRs HTR2A ADRB1 HTR1E HTR1F ADRB2 HTR1D HTR1B 5HT1A HTR2B HTR4 HRH1 HTR6 HTR7 HRH2 DRD5 ADRA2C CHRM2 HTR5A CHRM3 ADRA2B ADRA2A CHRM1 CHRM4 CHRM5 ADRA1D DRD4 ADRA1B DRD1 ADRA1A DRD2 DRD3 ADRB3 DOPAMINERGIC NEUROGENESIS%WIKIPATHWAYS_20260510%WP2855%HOMO SAPIENS Dopaminergic neurogenesis STAT3 SHH FOXA2 TGFB1 ASCL1 HEL-S-53e NEUROD1 GBX2 SLC6A3 DDC OTX2 CDKN1C MSX1 TH FGF8 NKX6-1 SLC18A2 NKX2-2 PITX3 EN2 SOX2 EN1 LMX1A LMX1B NEUROG2 RET WNT1 AUTOSOMAL RECESSIVE OSTEOPETROSIS PATHWAYS%WIKIPATHWAYS_20260510%WP4788%HOMO SAPIENS Autosomal recessive osteopetrosis pathways TCIRG1 TNFRSF11A RAB7A IKBKB TNFSF11 TRAF6 CLCN7 NFKB1 OSTM1 PLEKHM1 SNX10 RENIN ANGIOTENSIN SYSTEM AND BRADYKININ PATHWAYS IN COVID 19%WIKIPATHWAYS_20260510%WP4969%HOMO SAPIENS Renin Angiotensin System and Bradykinin pathways in COVID 19 TNF ACE2 PRKG1 CYP3A4 KNG1 REN BDKRB2 CYP24A1 BDKRB1 IL1A SERPING1 CPN1 IL1B KLNA1 KLKB1 MAPK1 AGTR1 ROCK1 AGTR2 NFKB1 ARHA NR1i1 GPR143 IN MELANOCYTES AND RETINAL PIGMENT EPITHELIUM CELLS%WIKIPATHWAYS_20260510%WP4941%HOMO SAPIENS GPR143 in melanocytes and retinal pigment epithelium cells CREB1 ASIP PLCB4 PRKACG ARRB2 GNA15 TYR PLCB1 VEGFA PLCB3 PRKCB PMEL TYRP1 GPR143 MC1R DCT ADCY9 POMC PLCB2 GNAS 5Q35 COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5380%HOMO SAPIENS 5q35 copy number variation INPP5D HK3 MAPK9 MAPK8 PLCG1 USH1C IGF1R CXCR4 MYC UIMC1 CYP7A1 ABRAXAS1 BRCC3 KDM6B FBXW7 CLTB SOS1 JUN SRC RGS14 PRR7 KIAA1191 FAF2 DDX41 GNAI3 TRIAP1 HEL-S-273 BABAM1 BABAM2 CAPN3 GNAI1 NELFB NTN1 ARL10 MAPK10 TMED9 RNF44 H3F3B UNC5A BRCA1 EED MYO7B FGF8A ARFGAP2 EIF4E1B HIC2 PTH SLC34A1 DOK3 MAX GPRIN1 GRB2 CDHR2 FAM193B FGFR4 PFN3 DBN1 MAGED1 ABHD5 COX7A1 LMAN2 RAB24 ZNF346 SNCB BARD1 PDLIM7 SNCA PRELID1 PTPRN2 NOP16 MUPCDH HIGD2A TSPAN17 ANKS4B COX7B RNP24 MXD3 PIK3R1 COX4I1 COX6A1 COX7C DRD2 FRS2 COX5A COX3 COX2 COX8A H2AX PNPLA2 COX6B1 TMED10 GRIN2B ADAM10 GRIN1 VITAMIN K METABOLISM AND ACTIVATION OF DEPENDENT PROTEINS%WIKIPATHWAYS_20260510%WP5186%HOMO SAPIENS Vitamin K metabolism and activation of dependent proteins VKORC1 UBIAD1 F2 F9 PROC F10 NQO1 GGCX PROS1 PROZ AIFM2 F7 15Q25 COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5408%HOMO SAPIENS 15q25 copy number variation SYNJ1 ALPK3 EGF ZSCAN2 SHANK1 AP3D1 PDE8A RAF1 RYR1 RYR2 SH3GL3 RAMAC ZNF592 AGAP2 TENT4B RNMT BTBD1 GOLGA6L4 ADAMTSL3 C15orf40 HTT FSD2 AP3S1 WHAMM SEC11A NMB BNC1 HOMER2 NMBR WDR73 TM6SF1 AP3B2 SHANK3 DNM3 SPCS3 SPCS2 SPCS1 NON CLASSICAL ROLE OF VITAMIN D%WIKIPATHWAYS_20260510%WP5133%HOMO SAPIENS Non classical role of vitamin D ACE2 AGTR1 AGTR2 REN CYP27B1 CYP2R1 PHOTODYNAMIC THERAPY INDUCED AP 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260510%WP3611%HOMO SAPIENS Photodynamic therapy induced AP 1 survival signaling MCL1 MAP2K3 MAPK12 TNFSF10 BMF MAPK11 BCL2L11 CDKN2A TNFSF6 BCL2L1 MAPK8 CDKN1A TRAF6 CCND1 MAPK14 IL2 MMP2 FAS MAP2K6 MAPK13 PDGFRA IFNG BCL2 TNF FGF7 TRAF2 IL6 TRAF5 BAK1 CCNA2 MAP2K4 JUN BAX CCNE1 NFE2L2 RB1 EGFR JUNB MAP3K5 TNFRSF1A HBEGF ATF2 FOS 15Q11Q13 COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5407%HOMO SAPIENS 15q11q13 copy number variation MTMR10 RELA SPEF1 OTUD7A SMC5 SMC6 ANKRD32 ANKRD2 GOLGA8R GOLGA8T KLF13 CXADR NSMCE3 NSMCE2 CREBBP NSMCE1 GOLGA8K GOLGA8J GOLGA8O GOLGA8Q GJD3 CANX GOLGA8H MYZAP FAN1 STXBP1 STX1A CCL5 NECAB3 CHRNA7 STX1B LYPD6 ENTREP2 CALM1 FANCD2 TRPM1 UBN1 MLSN2 SLF2 CGN CDC42BPB TJP3 HDAC1 TJP1 SIN3A CXNO GJA1 APP KAT2B TNF ALPHA SIGNALING%WIKIPATHWAYS_20260510%WP231%HOMO SAPIENS TNF alpha signaling DIABLO MAP2K3 APAF1 SKP1 CASP8 PRKCZ FADD BCL2L1 MAPK9 MAPK8 MAP3K8 MAPK3 CREBBP PYGL CYBA PLK1 CDC37 HRAS PPP2CA KSR1 TNFAIP3 SMPD2 PSMD2 PIG59 RIPK3 SOS1 FBXW11 MAP2K4 KSR2 TNFRSF1B JUN PTPRCAP NSMAF RFFL MAP3K7IP1 OTUD7B TBK1 BTRC MADD NFKBIB CSNK2A1 REL KRAS GRB2 NFKBIE MAP4K2 TAB3 TRAF1 IKBKB BIRC3 TXN NFKBIA MAP3K1 CHUK TRADD MAPK1 IKBKG RAC1 RAF1 MAP3K14 NFKB1 MAP2K6 TNF TRAF2 NRAS BIRC2 TANK RIPK1 BAD BAX CASP9 NFKB2 MAP3K7 CASP3 MAP3K5 TNFRSF1A GDNF RET SIGNALING AXIS%WIKIPATHWAYS_20260510%WP4830%HOMO SAPIENS GDNF RET signaling axis SLIT2 IFT27 SOX17 IFT25 BMP4 SPRY1 AGTR2 WT1 CTNNB1 GATA3 PAX2 SIX2 ALDH1A2 RET SOX11 ROBO2 FOXC2 FOXC1 HOXD11 HOXC11 GDNF HOXA11 ROBO1 SALL1 GLI3 EYA1 GREM1 LHX1 FAT4 TCF2 EMBRYONIC STEM CELL PLURIPOTENCY PATHWAYS%WIKIPATHWAYS_20260510%WP3931%HOMO SAPIENS Embryonic stem cell pluripotency pathways MAP2K3 MAP2K5 BRAF SMAD4 FGF2 CTNNB1 FGF7 FGF8 FGF9 SMAD1 SMAD9 DKFZp781O1323 JUN WNT4 FGF20 BMPR1A BMPR2 FGF23 FGF22 FGF21 ACVR1 FGF16 FGF14 ACTR2 FGF18 ERAS FGF13 ACVR2B FGF12 FGF10 WNT2B WNT5B FGF8A WNT9B WNT16 WNT3 FGF7B WNT10B WNT10A FZD3 FGF7A FZD2 FZD5 FZD4 MAPK1 WNT3A RAF1 WNT7B FZD7 FZD9 MAP2K6 FGF6B WNT7A FZD8 MAPK6 MAPK4 FGF5C MAPK12 JAK1 PTEN PIK3CD IL6ST AKT3 HRAS PDGFRA MAP2K2 NOG SOS1 DVL1 LIF DVL2 SMAD6 DVL3 AXIN1 LRP5 EGFR LRP6 WNT1 EGF STAT3 MTOR APC PDGFA MDM2 FZD1 GRB2 HNF1A FGFR4 FGFR3 BMP4 FGFR2 FGFR1 MAPK7 ARAF PIK3R2 PTPN11 GSK3B MAP2K1 SELENOP FOS 2Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP5223%HOMO SAPIENS 2q21 1 copy number variation syndrome CDC27 STAT3 AMER3 STMN2 MZT2A APC FAM168B CCDC74A POTEE GPR148 TUBA2 CCDC42 ARHGEF4 RAC1 ARHA SULFATION BIOTRANSFORMATION REACTION%WIKIPATHWAYS_20260510%WP692%HOMO SAPIENS Sulfation biotransformation reaction SULT2B1 SULT1E1 SULT6B1 SULT1C3 SULT1C2 PAPSS2 PAPSS1 SULT1A4 SULT1C4 HEL-75 SULT1A1 SULT2A1 SULT1A2 SULT1B1 GAMMA GLUTAMYL CYCLE FOR THE BIOSYNTHESIS AND DEGRADATION OF GLUTATHIONE%WIKIPATHWAYS_20260510%WP4518%HOMO SAPIENS Gamma glutamyl cycle for the biosynthesis and degradation of glutathione HEL-S-64p OPLAH GCLC C7orf24 STING PATHWAY IN KAWASAKI LIKE DISEASE AND COVID 19%WIKIPATHWAYS_20260510%WP4961%HOMO SAPIENS STING pathway in Kawasaki like disease and COVID 19 MITA IKBKE IRF3 F3 RELA REL FCGR2A NLRP3 IFNB1 GSDMD NFKBIE IKBKB IL1B NFKBIA CHUK IKBKG NLRX1 CGAS NFKB1 TBK1 GLYCOSAMINOGLYCAN SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260510%WP5395%HOMO SAPIENS Glycosaminoglycan synthesis in fibroblasts CHST3 HS3ST3A1 CHST11 CHST12 CHPF CHST13 HS3ST1 XYLT2 CHST14 HS3ST2 EXTL2 EXTL1 CHSY1 CHSY3 CSGALNACT1 CHPF2 B3GAT3 B3GAT2 GLCE B3GAT1 CSGALNACT2 UST HS2ST1 XYLT1 EXT1 EXT2 HS3ST3B1 CHST7 CHST1 HS6ST1 HS6ST2 HS6ST3 NDST3 B3GALT6 HINT1 PATHWAY%WIKIPATHWAYS_20260510%WP5523%HOMO SAPIENS HINT1 pathway HINT1 NFATC2 RUVBL2 RUVBL1 CTNNB1 TCF4 GTF2H2C_2 MAPK9 GTF2H2 GTF2H3 GTF2H5 JUN ERCC2 MNAT1 CCNH NFKB1 KARS1 FOS USF2 SH3RF1 CDK7 ACUTE VIRAL MYOCARDITIS%WIKIPATHWAYS_20260510%WP4298%HOMO SAPIENS Acute viral myocarditis CREB1 TLR4 CASP8 BCL2L1 DAG1 IL12B IL10 JAK1 CXADR MAPK3 IL12A CCR5 HEL-S-28 TGFB1 EIF4G1 CD55 STAT1 CD40LG CCND1 CXCR4 IL2 SOCS1 CYCS IFNG BCL2 HLA-DMA SOS1 SRC TLR5 CCR3 ABL2 AIF1 TICAM1 STAT3 FYN TLR3 PS1TP5BP1 RAC3 MAPK1 MMP9 TNF CAAP1 PIK3R1 PYCARD SGCD IL6 SGCA CASP6 SGCB CASP2 SGCG DFFB DFFA PABPC1 MYH6 GSK3B EDN1 CHRAC1 BNIP2 BAX DMD CASP9 MICA NFKB2 AAG1 CD80 CASP3 NOD2 PARP1 BIOTIN METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260510%WP5031%HOMO SAPIENS Biotin metabolism including IMDs PC MCCC2 BTD HLCS MCCC1 ACACB PCCA ACACA PCCB GANGLIO SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260510%WP1423%HOMO SAPIENS Ganglio sphingolipid metabolism ST8SIA1 B3GALT4 ST8SIA5 ST3GAL5 B4GALNT1 SLC33A1 B3GALT1 FUT1 A3GALT2 ST3GAL1 ST6GALNAC6 PHYSICO CHEMICAL FEATURES AND TOXICITY ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260510%WP3680%HOMO SAPIENS Physico chemical features and toxicity associated pathways MAPK8 DAAM1 CDKN1A PLCG1 MYC ARHA MYLK PPP2CA CTNNB1 HEL-S-44 MYL1 SOS1 NCK1 PFN1 MAP2K4 DVL1 JUN SHC1 SRC AXIN1 EGFR TGFA CBL ACTR2 FZD10 APC TMSB4X WNT16 FZD1 GRB2 PFN3 FZD3 FZD2 FZD5 MAPK1 FZD4 CAMK1 RAF1 ROCK2 FZD7 FZD9 FZD8 PAK1 ERBB4 NEF3 GPX1 NEFL GSK3B CDKN1B ACTA1 MAP2K1 NEFH ACTR3 PFN4 PFN2 ERBB2 KALLMANN SYNDROME%WIKIPATHWAYS_20260510%WP5074%HOMO SAPIENS Kallmann syndrome MYRF MAP2K2 LHB SEMA3E OTX2 OLIG2 SOX10 FGF8 TMEM98 ANOS1 PROK2 GNRH1 FRS2 NEUROG1 GRB2 PTPN11 PLXND1 PIK3CA FGFR1 MAPK1 ASCL1 KENNEDY PATHWAY FROM SPHINGOLIPIDS%WIKIPATHWAYS_20260510%WP3933%HOMO SAPIENS Kennedy pathway from sphingolipids CEPT1 PEMT PTDSS2 SGPL1 PTDSS1 PCYT1B CHKB PCYT2 CHKA ETNK1 PISD UREA CYCLE AND ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260510%WP4595%HOMO SAPIENS Urea cycle and associated pathways ASL NAGS MDH2 GOT2 NOS2 GLS2 SLC25A15 LDHB GLUD1 SLC25A12 SLC25A13 OTC FH HEL-S-32 GPT ARG1 ASS1 HLA C ALLOTYPES INTERACTIONS WITH KIR ON DNK CELLS%WIKIPATHWAYS_20260510%WP5580%HOMO SAPIENS HLA C allotypes interactions with KIR on dNK cells IFNG TNF CSF2 FYN PTPN6 HLA-C PLCG1 LCP2 SYK LAT PRKCA VAV1 KIR2DL1 KIR2DL3 TYROBP NLRP7 NLRP2 RAC1 ELF3 PRKCQ TGF BETA RECEPTOR SIGNALING IN SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260510%WP4816%HOMO SAPIENS TGF beta receptor signaling in skeletal dysplasias EP300 MAPK9 JAK1 MAPK3 CREBBP TGFB1 STAT1 ADAMTSL2 SMAD2 SMAD4 pp6425 FBN1 HRAS TGFBR1 LEFTY1 IFNG CTNNB1 ZFYVE9 ITGB6 SMAD1 NOG SMAD9 FOXH1 RUNX3 ENG FST LTBP1 SKIL DKFZp781O1323 LIF LEFTY2 JUN SMAD6 SKI BAMBI LEF1 WNT1 EGF STAT3 TGFBR3 INHBA RUNX2 BMP4 FKBP1A THBS1 NFKB1 TNF TGFBR2 ZNF423 SPP1 ZEB2 TGIF1 FOS ASPIRIN PREVENTION OF CANCER METASTASIS%WIKIPATHWAYS_20260510%WP5518%HOMO SAPIENS Aspirin prevention of cancer metastasis TBXA2R ARHGEF1 ARHA PTGS1 GNA13 ISOGLOBO SERIES SPHINGOLIPIDS%WIKIPATHWAYS_20260510%WP5311%HOMO SAPIENS Isoglobo series sphingolipids B3GALT5 KCNQ2 RELATED EPILEPSIES%WIKIPATHWAYS_20260510%WP5360%HOMO SAPIENS KCNQ2 related epilepsies CHRM1 CALM1 AKAP5 CSNK2A1 KCNQ2 KCNQ3 BDKRB2 PLCG2 PRKCA PPP3CC AGTR1 PPP1R10 BACE1 STX1A P2RY1 SCN1B GDNF SIGNALING%WIKIPATHWAYS_20260510%WP5143%HOMO SAPIENS GDNF signaling MOLYBDENUM COFACTOR MOCO BIOSYNTHESIS%WIKIPATHWAYS_20260510%WP4507%HOMO SAPIENS Molybdenum cofactor Moco biosynthesis MOCS2 MTARC2 MOCS1 GPHN AOX1 XDH SUOX NSAIDS MECHANISM OF ACTION%WIKIPATHWAYS_20260510%WP5513%HOMO SAPIENS NSAIDs mechanism of action PTGS2 PTGS1 PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS %WIKIPATHWAYS_20260510%WP2572%HOMO SAPIENS Primary focal segmental glomerulosclerosis FSGS TLR4 LAMB2 VTN AGRN DAG1 CDKN1A PLCG1 HEL-S-28 TGFB1 SMARCAL1 HEL113 CD151 PLCE1 TLN1 CTNNB1 CDKN1C SCARB2 PTPRO MKI67 SYNPO KIRREL3 TRPC6 KIRREL2 DKK1 LMX1B YWHAQ MME PLAUR ACTN4 NCK1 CD2AP INF2 MYH9 PARVA MYO1E NPHS1 PCNA NPHS2 LRP5 LIMS1 ITGB3 LRP6 WNT1 CLDN1 ITGAV CTSL CDH2 ITGB1 FYN LAMA5 HEL114 WT1 IRF6 CR1 PAX2 NOTCH1 COL4A4 COL4A3 COL4A5 ITGB4 FAT1 CDKN1B CD80 METABOLIC EPILEPTIC DISORDERS%WIKIPATHWAYS_20260510%WP5355%HOMO SAPIENS Metabolic epileptic disorders HK3 GLDC PGAM1 ECHS1 SHMT1 AMT SLC25A15 ALDH7A1 LDHB GLUD1 ALDOB DLD G6PC1 MOCS2 MOCS1 GPHN XDH MOCS3 ENO2 ENO3 DHTKD1 MPC1 PDHA1 HEL-S-32 MPC2 AASS SLC25A5 FBP2 HK2 FBP1 GCDH SLC2A2 SLC7A2 PC PKLR CBS AADAT DLAT SQOR PCK1 GCK CDO1 HEL60 PSAT1 PHGDH GLS2 HEL-S-51e PSPH OTC HEL-S-87p HEL-S-30 PGAM2 HEL-S-133P GPT ENO1 ARG1 HEL-S-68p ASS1 PFKM HEL-S-162eP ASL HEL-S-49 SLC2A4 MDH2 GOT2 PFKP HEL-S-20 SLC2A3 ETHE1 SUOX PFKL SFXN1 SLC25A1 BTD HLCS CTH ACAT1 SPCS1 TRANSCRIPTION ACTIVATION RNA POLYMERASE I AND KAT2A B AND INHIBITION NURD COMPLEX %WIKIPATHWAYS_20260510%WP5565%HOMO SAPIENS Transcription activation RNA polymerase I and KAT2A B and inhibition NuRD complex H2AB1 EP300 H2AJ H3C15 POLR1A POLR1C MAPK3 POLR1D CREBBP SRCAP HDAC2 HDAC1 SIRT7 RBBP4 H3F3B PWWP2B H2AC19 CHD4 H2AC14 H2BC26 H2BC12L H2BC21 TLK2 UBTF PWWP2A HIST1H2AB H2AC6 H2BC17 H2BC12 H2BC13 KAT2A H2AZ1 TBP H2BC14 H2BC15 H4C9 HAT1 H2BC11 HIST1H2BE HIST1H4L ASF1A ASF1B RRN3 TAF1D TAF1B EP400 H2BC9 MBD3 H2BC8 TAF12 H2BC3 MBD2 H2BC1 GATAD2A H2AC20 CDK2AP1 H2AX CHD3 GATAD2B MTA2 H2AZ2 H3C8 KAT2B NANOMATERIAL INDUCED INFLAMMASOME ACTIVATION%WIKIPATHWAYS_20260510%WP3890%HOMO SAPIENS Nanomaterial induced inflammasome activation IL1B TLR4 PYCARD NFKB1 ENDOCHONDRAL OSSIFICATION%WIKIPATHWAYS_20260510%WP474%HOMO SAPIENS Endochondral ossification PLAT STAT5B TGFB1 MGP SOX6 STAT1 IGF1R GHR IGF2 FGF2 CALM1 CDKN1C RUNX3 BMP6 BMPR1A GLI3 IGF1 MEF2C THRA FGF18 IHH PTH1R PTHLH PTH FRZB PTCH1 CHST11 RUNX2 ALPL FGFR3 FGFR1 MMP9 BMP7 GH1 ACAN SPP1 COL10A1 ADAMTS4 SOX9 ADAMTS5 ENPP1 TIMP3 HMGCS1 NKX3-2 KIF3A SOX5 CAB39 CST5 VEGFA COL2A1 SCIN DDR2 SCFA AND SKELETAL MUSCLE SUBSTRATE METABOLISM%WIKIPATHWAYS_20260510%WP4030%HOMO SAPIENS SCFA and skeletal muscle substrate metabolism GCG SLC2A4 PYY FFAR3 NR1C2 FFAR2 MICROTUBULE CYTOSKELETON REGULATION%WIKIPATHWAYS_20260510%WP2038%HOMO SAPIENS Microtubule cytoskeleton regulation EPHB2 STAT3 TRIO TIAM1 APC F2RL2 MAPKAPK2 PARD6A SPRED1 PTEN RHO MARK1 CAMK4 NTRK3 WNT3A ROCK1 RAC1 CDC2 CDC42 PAK1 CFL2 LIMK1 GSK3B DVL1 SRC PRKCA AURKB FREP1 CLASP1 TAOK1 MAP1B MAPRE1 NTRK1 PHLDB2 NTRK2 POLYOL PATHWAY%WIKIPATHWAYS_20260510%WP690%HOMO SAPIENS Polyol pathway ALDOB KHK SORD AKR1B1 FTO OBESITY VARIANT MECHANISM%WIKIPATHWAYS_20260510%WP3407%HOMO SAPIENS FTO obesity variant mechanism PRDM16 UCP1 IRX5 ARID5B TBX1 PPARGC1A IRX3 GLYCEROL METABOLISM INCLUDING LINKED IMDS%WIKIPATHWAYS_20260510%WP5570%HOMO SAPIENS Glycerol metabolism including linked IMDs GLYCTK HEL-S-49 PC PKLR AQP7 GPD2 GPD1 PCK1 LIPE PGAM1 MGLL PFKL ALDOB PNPLA2 HEL-S-165mP HEL-S-87p AGXT G6PC1 ENO1 KHK HEL-S-68p FBP1 HEL-S-162eP DIRECT REVERSAL REPAIR%WIKIPATHWAYS_20260510%WP4931%HOMO SAPIENS Direct reversal repair ALKBH3 ALKBH2 MGMT DDX1 AS A REGULATORY COMPONENT OF THE DROSHA MICROPROCESSOR%WIKIPATHWAYS_20260510%WP2942%HOMO SAPIENS DDX1 as a regulatory component of the Drosha microprocessor MRE11A NBN DGCR8 DROSHA ATM DDX1 RAD50 FACTORS AND PATHWAYS AFFECTING INSULIN LIKE GROWTH FACTOR IGF1 AKT SIGNALING%WIKIPATHWAYS_20260510%WP3850%HOMO SAPIENS Factors and pathways affecting insulin like growth factor IGF1 Akt signaling ACVR2B ITGB1 WASL MTOR TRIM63 FBXO32 GDF8 PTEN HEL-S-28 IGF1R RPTOR RPS6KB1 DEPTOR PRKAB1 SMAD2 IGFBP5 TNLG5A NFKB1 MAP1LC3A MLST8 EIF2B2 AKT1S1 MAPKAP1 RICTOR GSK3B EIF4E IRS1 TNFRSF1A IGF1 PPARGC1A GNAQ P R183Q DRIVES CAPILLARY MALFORMATION%WIKIPATHWAYS_20260510%WP5501%HOMO SAPIENS GNAQ p R183Q drives capillary malformation PPP3R1 PRKD1 PRKD2 ANGPT2 PRKCZ PKN3 PKN2 PKN1 NFATC1 PRKCH PLCB3 PRKCB PPP3R2 PRKCE PRKCA PPP3CC PRKCI PPP3CA PRKD3 PRKCQ SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260510%WP4658%HOMO SAPIENS Small cell lung cancer LAMA4 LAMA3 APAF1 RARB LAMB3 SKP1 BIRC7 LAMB2 LAMB4 CASP8 RELA LAMB1 CCNE2 BCL2L1 CKS2 CDKN1A PTEN PIK3CD CCND1 MYC AKT3 CYCS CDK2 BCL2 CDKN1C RXRA PIK3CA RB1 ITGA6 LAMC1 ITGAV FHIT CDKN2B ITGA2B NFKBIB ITGB1 LAMA5 MAX NOS2 COL4A2 CDK6 CDK4 TRAF1 IKBKB TRAF4 BIRC3 NFKBIA CHUK TRAF6 IKBKG POLK ITGA2 NFKB1 DDB2 PIK3R3 PIK3R2 TRAF2 PIK3R1 TRAF5 TRAF3 E2F2 BIRC2 E2F3 BAK1 GADD45B COL4A1 PTGS2 COL4A4 GADD45A COL4A3 COL4A6 GADD45G COL4A5 BAX CASP9 CDKN1B CCNE1 LAMC2 CASP3 CKS1B RXRB RXRG LAMA1 BIOSYNTHESIS AND TURNOVER OF 1 DEOXY SPHINGOID BASES%WIKIPATHWAYS_20260510%WP5179%HOMO SAPIENS Biosynthesis and turnover of 1 deoxy sphingoid bases SPHK1 SPHK2 KDSR SGPP2 SGPP1 SPTLC2 SPTLC1 ROBO4 AND VEGF SIGNALING CROSSTALK%WIKIPATHWAYS_20260510%WP3943%HOMO SAPIENS ROBO4 and VEGF signaling crosstalk VEGFA SRC SLIT2 RAC1 KDR ROBO4 OXIDATIVE DAMAGE RESPONSE%WIKIPATHWAYS_20260510%WP3941%HOMO SAPIENS Oxidative damage response C1R APAF1 MAPK10 C5AR1 C4B_2 C2 CDKN1A BAG4 NFKBIE TNK2 TRAF1 MAP3K1 TRAF6 NFKB1 CYCS MAPK13 C1QC CDC42 BCL2 TNF C3AR1 CDKN1C TRAF2 CR2 TRAF3 BAK1 BAD GADD45A MAP2K4 TNFRSF1B C1QA CASP9 PCNA CDKN1B CASP3 C1QB C1S DUAL HIJACK MODEL OF VIF IN HIV INFECTION%WIKIPATHWAYS_20260510%WP3300%HOMO SAPIENS Dual hijack model of Vif in HIV infection CBFB RUNX1 APOBEC3G CUL5 UBB ELOC RBX1 MFAP5 MEDIATED OVARIAN CANCER CELL MOTILITY AND INVASIVENESS%WIKIPATHWAYS_20260510%WP3301%HOMO SAPIENS MFAP5 mediated ovarian cancer cell motility and invasiveness JUN CREB1 MAPK3 TNNC1 ITGB3 MAPK1 MFAP5 RYR3 ITGAV PRKCQ PLCG1 GLYCOGEN SYNTHESIS AND DEGRADATION%WIKIPATHWAYS_20260510%WP500%HOMO SAPIENS Glycogen synthesis and degradation GYS1 HK3 PPP2R5E GSK3A PPP2R5C PTPA GYS2 PYGB PYGL PPP2R2A GYG1 PYGM PPP2R1B PPP2R1A AGL PPP2R5B PPP2R5A PPP2R5D PPP2R3B PHKB PHKA1 PPP2CA PPP2R3A CALM1 PHKA2 PPP2R2C PPP2R2B GSK3B PHKG2 HK2 LINOLEIC ACID METABOLISM AFFECTED BY SARS COV 2%WIKIPATHWAYS_20260510%WP4853%HOMO SAPIENS Linoleic acid metabolism affected by SARS CoV 2 ACE2 FADS2 FADS1 ELOVL5 ELOVL2 MRNA PROTEIN AND METABOLITE INDUCED STRESS PATHWAY BY CYCLOSPORIN A%WIKIPATHWAYS_20260510%WP3953%HOMO SAPIENS mRNA protein and metabolite induced stress pathway by cyclosporin A SLC3A2 NFE2L2 SLC7A11 SLC7A5 ATF4 KEAP1 SOMITOGENESIS IN THE CONTEXT OF SPONDYLOCOSTAL DYSOSTOSIS%WIKIPATHWAYS_20260510%WP4785%HOMO SAPIENS Somitogenesis in the context of spondylocostal dysostosis DLL3 MESP2 LFNG HES7 RIPPLY2 TBX6 EPHA4 NOTCH1 MBDNF AND PROBDNF REGULATION OF GABA NEUROTRANSMISSION%WIKIPATHWAYS_20260510%WP4829%HOMO SAPIENS mBDNF and proBDNF regulation of GABA neurotransmission GABRA3 CREB1 STAT3 PLCG1 PTEN GABRG3 GABRG2 ROCK1 GABRG1 ARHA CREM PIK3R3 PIK3R2 BDNF PIK3R1 GABRB3 GABRB2 GABRB1 AP2A1 AP2A2 PIK3CA SHC1 GABRE GABRQ GABRA2 GABRP SLC12A5 GABRA6 GABRA5 NGFR NTRK2 GABRA4 NEOLACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260510%WP5302%HOMO SAPIENS Neolacto series sphingolipid metabolism B4GALT1 FUT2 B3GNT5 SIAT4C FUT1 B4GALT4 NEU2 FUT5 FUCA1 NAGA BURN WOUND HEALING%WIKIPATHWAYS_20260510%WP5055%HOMO SAPIENS Burn wound healing TLR4 S100A6 TIMP1 IL15 CD3E CXCR4 FBN1 PECAM1 CHRNA7 CCL2 BCL2 CXCL12 MYD88 DCN COL1A2 FST ACHE FOXE1 HEXD TNC F13A1 DKFZp686P11128 MMP28 KRT222 PCTK1 FLG BRD4 AMBP HEL-S-43 S100A9 SLURP1 SCEL LIN28A TPT1 EGF HMGB1 HGF KRT6A INHBA FGFR4 FGFR3 FGFR2 KLF4 FGFR1 IL1B CXCL1 MMP2 NFKB1 MMP9 IFNA2 TNF IL6 IL8RB IFNB1 CXCL8 COL1A1 BAX VEGFA CASP3 ACTA1 SNAI2 NOX4 17Q12 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP5287%HOMO SAPIENS 17q12 copy number variation syndrome STAC2 PEX12 TCAP CDK12 SPMAP1 TEC ACACA CCL8 CCL7 CCL5 CCL4 CCL3 STARD3 CCL2 PPP1R1B PIP4K2B RFFL MMP28 LHX1 TCF2 PNMT DHRS11 PGAP3 TBC1D3B CCL4L2 TBC1D3E TBC1D3C CWC25 PIGW TBC1D3I AATF IKZF3 CCL11 CISD3 DUSP14 TBC1D3H CCT6B RDM1 CCL1 ARL5C C17orf50 GPR179 CCL15 UNC45B MED1 SLC35G3 RPL23 SRCIN1 FNDC8 SLFN12 SLFN13 RAD51D TBC1D3 SLFN11 SLFN14 ZNF830 CCL14 SLFN5 CCL13 GGNBP2 CCL3L3 FBXO47 MRM1 MLLT6 FBXL20 NEUROD2 MIEN1 ZNHIT3 LYZB C17orf78 ASIC2 CCL18 GAS2L2 SOCS7 CCL16 HEATR9 TAF15 TMEM132E CACNB1 RASL10B PCGF2 SYNRG EPOP PLXDC1 NLE1 ARHGAP23 GRB7 ERBB2 TBC1D3K NRP1 TRIGGERED SIGNALING IN PANCREATIC CANCER %WIKIPATHWAYS_20260510%WP5144%HOMO SAPIENS NRP1 triggered signaling in pancreatic cancer EGF NRP1 SEMA3A TGFBR3 RELA PLXNA1 HGF PLXNA4 CCNE2 REL GSK3A FLT1 MAPK3 SNAI1 CHD2 MAPK1 SMAD2 RAC1 SMAD4 AKT3 MMP2 KDR NFKB1 MMP9 TGFBR1 PECAM1 MAP2K2 CDK2 TGFBR2 RELB CTGF COL1A2 MET COL1A1 VEGFA NFKB2 SRC CDKN1B PLXNA2 CCNE1 EGFR MAP2K1 SNAI2 SELENIUM MICRONUTRIENT NETWORK%WIKIPATHWAYS_20260510%WP15%HOMO SAPIENS Selenium micronutrient network SELS RELA HEL-S-97n KYNU KMO PRDX3 PRDX5 HEL-S-2a ALOX5AP PLAT HEL-S-302 CRP IFNG CCL2 SCARB1 HEL-S-44 LDLR HBB HBA2 ALOX15B MPO ALOX5 XDH APOB SERPINA3 FLAD1 FGA F7 SAA4 PLG INSR CBS MTR HEL-S-78p ALB SAA1 SAA2 IL1B TXN F2 NFKB1 ABCA1 TNF SELENOF SELENOK SELENOI GPX4 SELENOH IL6 SEPHS2 GPX2 GPX1 PTGS2 PTGS1 TXNRD3 GPX3 TXNRD2 GPX6 DIO1 NFKB2 SELENOO SELENON HEL-75 SELENOM CTH SELENOP SELENOW INS SELENOV SELENOT MSRB1 NIFEDIPINE ACTIVITY%WIKIPATHWAYS_20260510%WP259%HOMO SAPIENS Nifedipine activity PCNA PTK2B HEL-S-44 MAPK1 CYP3A4 MAP2K1 BDKRB2 KDR JAK STAT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260510%WP5528%HOMO SAPIENS JAK STAT signaling and ARTD family members HDAC3 DTX3L BTRC STAT3 PARP14 HDAC2 STAT1 SKP1 RBX1 PARP1 PARP11 PATHOPHYSIOLOGICAL ROLES OF DUX4 IN FSHD1%WIKIPATHWAYS_20260510%WP5342%HOMO SAPIENS Pathophysiological roles of DUX4 in FSHD1 EP300 TRIM63 ADRB2 FBXO32 MYOG CDKN1A RET VEGFA H3Y1 H3Y2 MYOD1 DUX4 NR3A2 PAX7 MYF5 MYC PPARGC1A GENE REGULATORY NETWORK MODELING SOMITOGENESIS %WIKIPATHWAYS_20260510%WP2854%HOMO SAPIENS Gene regulatory network modeling somitogenesis HES1 FGF8 MESP2 LFNG HES7 RIPPLY2 WNT3A TBX6 EPHA4 NOTCH1 RAS SIGNALING%WIKIPATHWAYS_20260510%WP4223%HOMO SAPIENS Ras signaling RASGRF1 TIAM1 RELA MAPK9 MAPK8 SHOC2 PLCG2 PLCG1 MAPK3 ARF6 PLA2G6 PLCE1 ARHA PRKACG KSR2 PIK3CA STK4 ETS2 RAC3 FOXO4 RRAS2 IKBKB CHUK RRAS MAPK1 IKBKG RAF1 NFKB1 CDC42 RALBP1 RAP1A SYNGAP1 RASGRP4 PRKCB PLD2 RASGRP3 PRKCA GRIN2B GRIN1 RALA RALB ZAP70 RAB5B GAB2 TNFSF6 EXOC2 BCL2L1 GNG12 GNG11 FLT1 GNG13 FLT3 FLT4 RAB5A PIK3CD IGF1R RIN1 PLA1A GNB2 HTR7 PLA2G3 AKT3 RASAL1 GNB1 KDR RASAL3 TTBK1 GNB4 AFDN GNB3 HRAS GNB5 RASGRF2 PDGFRA PLA2G12A MAP2K2 CALM1 PLA2G4F RASA4B KSR1 PLA2G12B PLA2G4D PLA2G4E PLA2G4B PLA2G4C PLAAT3 RASA3 GNGT1 RASA4 KIT RASA2 RAPGEF5 SOS1 PLA2G1B SOS2 PLA2G2F MET PLA2G2D EPHA2 PLA2G2E CSF1R PLA2G5 PLA2G2C SHC1 LAT EGFR SHC4 SHC3 NTRK1 NGFR NTRK2 PAK6 ABL2 INSR PAK4 GNG3 MAPK10 GNG2 GNG5 GNG4 PLA2G2A REL GNG7 KRAS GRB2 GNG8 FGFR4 FGFR3 FGFR2 FGFR1 CALML6 PLA2G10 GNGT2 CALML3 CALML4 RASSF1 RAC1 SHC2 PIK3R3 PIK3R2 PIK3R1 RAB5C NRAS PAK1 GNG10 BAD PTPN11 NF1 MAP2K1 MIR TARGETED GENES IN MUSCLE CELL%WIKIPATHWAYS_20260510%WP2005%HOMO SAPIENS miR targeted genes in muscle cell GPD2 CSF1 PKN2 POLE4 POLA2 CBFB MAPK14 IGF2R FGF2 BCL2 CTNNB1 TNFRSF10B LPL DNAJB1 FADS2 RAB27B PICALM HEL-S-30 MBNL1 GNA13 HYAL3 GRIA2 BACE1 NRP1 CDKN1A CCND1 PPP3CA PPP1R7 SH3BP4 SDCBP CXCL12 KIT MET CPNE8 NCL VEZT TMEM41B BACH1 PWP1 CSNK1D RAVER2 EGFR CIAO2A SEC62 HEL-S-303 CACNA2D1 FNDC3B FNDC3A MTRR CARHSP1 HEL-S-273 WDR82 FAR1 TMEM87A HACD3 UBE2J1 COMMD9 GRPEL2 ATP6V1C1 MOV10 RHEB NCEH1 PDE3A STRN KRAS ANP32B GFM1 MAGT1 PANX1 PTPRF COIL SERP1 RDH10 C1QBP GNPNAT1 TUSC2 MAPK7 TMED7 ARID4B MRPS24 IGF2BP1 ELMOD2 TXN2 TMT1A CHORDC1 AP3B1 PDLIM7 VSNL1 CDK5RAP3 CSDE1 ARHG THBS1 VPS39 PXDN ATP6V0E1 AMIGO2 FSTL1 ITGA2 IFRD1 NAPG NT5E HEL-S-66 PISD MPZL1 RNP24 SPRYD4 RAB34 TTC9C PPIF TPPP3 GPAM NFIA NEDD4 SLC1A4 SNX15 ADIPOR2 LAMTOR5 RTN4 LTN1 CORO1C E2F3 MRPL20 CPOX ABHD10 POGLUT3 KPNA3 SNX6 SLC38A1 RARS1 CD164 TPM1 STX7 BRPF3 UBE4A TBCA CDKAL1 ITGB4 SFXN1 RAB30 CDKN1B SYPL1 SLC25A1 ARF4 PTMAP7 SLC12A2 TRAM1 GEMIN7 SRSF9 ABCG2 TMED10 RAI14 TNFAIP2 CAMTA1 ADAR SLC38A5 LMNB2 TM6SF1 GFPT1 SNAP23 MRC2 SLC4A10 TMEM43 SPCS3 GNL3L TMED3 CHMP2A SRPRB TMEM109 CYP51A1 SH3BGRL3 DKFZp761E1322 POLD2 CALCOCO2 ACP2 NELFCD DOCK7 CTSC CYR61 SYNE2 SCYL1 SLC7A6 SYNE1 CDCP1 HEL-S-108 HSDL1 RFT1 FRG1 RCN2 RBMS1 DSG2 ANAPC1 SEC23A HEL-S-47e PTPA LUZP1 CYP1B1 SHOC2 NUFIP2 NXN CDIPT CA12 HSD17B12 AP3D1 ACVR1B HES1 ARCN1 ATG9A CAND1 WDR11 TDG TP53INP1 FMNL2 ZNF622 SLC25A24 GALNT7 NHERF2 GALNT1 SLC4A7 SLC25A32 PLK1 BET1 SPTLC1 DHX15 USP1 RB1 MTHFD2 SRSF10 GSTM4 LAMC1 CLDN1 TPM3 ARID1A EHMT1 CDK6 TYMS EZH2 LAMTOR3 PGRMC1 POLR2C CEBPB GJA1 DOCK5 COL1A1 COL3A1 SNAP29 LAMC2 IRS1 ASH2L ERBB2 MCL1 MAPK12 SLC7A11 HMOX1 SSNA1 SLC25A13 CUL4B AXL MYLIP ATP2A2 RQCD1 YWHAQ COL1A2 P4HA2 PPIB MYO1E SPARC ERBB3 HMGA1 ERG PSAT1 CCNG1 TGFBR2 NOTCH2 NOTCH1 NF2 EIF4E PRKCI PHLDB2 UHRF1 CARDIOMYOCYTE SIGNALING CONVERGING ON TITIN%WIKIPATHWAYS_20260510%WP5344%HOMO SAPIENS Cardiomyocyte signaling converging on titin TCAP ADRB1 TRIM63 ADRB2 MDM2 ANKRD2 MAPK1 RAF1 GUCY1B1 FHL1 MYPN TTN CSRP3 NUP62 MAP2K2 ANKRD1 HEL-S-101 ANKRD23 PRKACG C22orf13 NBR1 TRIM55 FHL2 PRKCA CAMK2A MAP2K1 PRKAR1A GALANIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260510%WP4970%HOMO SAPIENS Galanin receptor pathway CREB1 YAP1 SLC2A4 CDKN1C VAMP2 IL6 BCL2L11 PPARG CDKN1A CRP VEGFA CDKN1B POMC INS FOS RETINOID METABOLISM IN RETINA HEALTHY VS RLBP1 DEFICIENT%WIKIPATHWAYS_20260510%WP5532%HOMO SAPIENS Retinoid metabolism in retina healthy vs RLBP1 deficient RLBP1 OVARIAN INFERTILITY%WIKIPATHWAYS_20260510%WP34%HOMO SAPIENS Ovarian infertility NCOR1 CREB1 FIGLA EGR1 SYNE2 MTOR NR5A1 FMR1 FSHR DMC1 ZP3 CDK4 TBP NR3A2 PGR PRLR NR1i1 CEBPB TSC2 TSC1 LHCGR INHA ZP2 GJA4 DAZL PTGER2 GDF9 CDKN1B ATM CCND2 SMPD1 RAD51 PSORIASIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260510%WP5537%HOMO SAPIENS Psoriasis mechanism and therapies STAT3 TNF IL23A CCR6 HLA-C IL17RC IL12B IF2B1 CXCL8 IL23R IL1B IL17F IL17A CXCL1 CCL20 TYK2 IL12RB1 BASE EXCISION REPAIR%WIKIPATHWAYS_20260510%WP4752%HOMO SAPIENS Base excision repair POLD2 PARP3 HMGB1 PARP2 APTX POLE RFC3 RFC4 LIG1 RFC1 POLE4 RFC2 POLD3 TDG POLE3 FEN1 POLE2 MPG OGG1 PNKP APEX1 UNG NTHL1 POLL MUTYH TDP1 MBD4 PCNA PARP4 ADPRHL2 SMUG1 NEIL3 NEIL2 POLG2 NEIL1 PARP1 POLD4 POLG HIPPO MERLIN SIGNALING DYSREGULATION%WIKIPATHWAYS_20260510%WP4541%HOMO SAPIENS Hippo Merlin signaling dysregulation YAP1 AMOT CDH11 RBX1 PPP1R14A HEL-S-80p FLT1 FLT3 ITGA4 CUL4A FLT4 DDB1 IGF1R CCND1 MYC FOXM1 KDR HRAS PDGFRA WWTR1 CTNNB1 PRKACG PLCB4 ITGB6 KIT TEAD4 MET EPHA2 CSF1R ITGB3 EGFR ITGA6 ITGB5 ITGAE ITGAV NTRK1 DCAF1 NGFR PPP1CC NTRK2 ITGB8 PAK6 ITGA7 ITGA2B PAK4 INSR CDH2 ITGB1 KRAS TEAD2 FGFR4 TEAD3 FGFR3 ITGA1 FGFR2 CD44 FGFR1 VGLL4 ITGAM CDH17 CDH9 ITGA2 ITGB7 CDH8 CDH6 CDH4 ITGAX CTNNA1 NRAS CTGF PAK1 AJUBA CDH24 LIN28B NF2 ITGB4 LATS1 LATS2 CDH10 CDH12 PRKAR1B CDH15 CDH16 PRKAR1A CDH18 CDH19 BARDET BIEDL SYNDROME%WIKIPATHWAYS_20260510%WP5234%HOMO SAPIENS Bardet Biedl syndrome TTC8 MKS1 IFT27 EFHC2 CLUAP1 INVS CEP164 FLCN DYNC2I2 TRAF3IP1 IFT172 GLI3 IFT52 TMEM107 ZIC2 CNGA1 NEK1 BBS9 BBS7 SCAPER CFAP418 CFAP410 PKD1 IFT57 RP2 MAK EFHC1 PTCH1 BBS5 CNGB1 BBS4 SDCCAG8 DYNC2H1 CRX PKD1L1 PKHD1 IFT140 SMO PDE6D NPHP3 USP9X IFT80 PCARE GPR161 DCDC2 WDR35 CEP41 LZTFL1 TRIM32 BBS10 IFT43 OCRL EVC NEK8 BBS12 IFT81 TMEM216 WDPCP BBIP1 SUFU CEP104 KIF7 ARL6 ARL3 DYNLT2B DYNC2LI1 IFT74 ARL13B TMEM67 RAB23 INPP5E CEP290 IQCB1 EVC2 BBS2 BBS1 SCLT1 FUZ GENES CONTROLLING NEPHROGENESIS%WIKIPATHWAYS_20260510%WP4823%HOMO SAPIENS Genes controlling nephrogenesis ITGB1 LAMB2 SLIT2 SHH ETV4 FGFR2 HEL-S-28 KIRREL1 MAFB CXCR4 KDR CD36 WT1 CTNNB1 FGF8 TCF21 PAX2 CXCL12 EMX2 NOTCH2 LMX1B NCK2 NCK1 CD2AP RET WNT4 FOXD1 VEGFA NPHS1 ROBO2 NPHS2 FOXC2 FOXC1 HOXD11 SIX1 GDNF HOXA11 GLI3 EYA1 LHX1 TCF2 DEVELOPMENT AND HETEROGENEITY OF THE ILC FAMILY%WIKIPATHWAYS_20260510%WP3893%HOMO SAPIENS Development and heterogeneity of the ILC family ZBTB16 IL7 IL9 HNF1A IL13 IL12B IF2B1 IL12A IL15 RORC IL1B RORA AHR ID2 GFI1 ATL1 IL33 TSLP TOX IL18 IFNG TNF IL23A IL25 IL6 GATA3 NFIL3 AREG TBX21 IL4 IL17A IL5 CANNABINOID RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP3869%HOMO SAPIENS Cannabinoid receptor signaling MAPK12 MAPK10 MAPK11 MAPK9 MAPK8 MAPK3 DAGLA AHR CNR1 MAPK1 MAPK14 CYP1A1 MAPK13 NAPEPLD DAGLB FAAH PRKACG CYP3A4 CYP2C19 CYP2C9 ADORA2A CNR2 PRKAR1B PRKAR1A ADCY1 COHESIN COMPLEX CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260510%WP5117%HOMO SAPIENS Cohesin complex Cornelia de Lange syndrome APC PPP2R5E PPP2R5C PTPA RAD21 PPP2R1B PPP2R1A NIPBL PLK1 PPP2R5B PPP2R5A PPP2R5D CDC2 CDCA5 PDS5B STAG2 PDS5A PPP2CA HDAC8 SGOL1 WAPAL ESCO1 ESCO2 SMC1A REC8 SMC1B MAU2 ESPL1 STAG3 AURKB SMC3 PTTG1 OMEGA 3 OMEGA 6 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260510%WP4723%HOMO SAPIENS Omega 3 omega 6 fatty acid synthesis PLA2G5 FACL4 ACSL3 FADS2 ACOX3 PLA2G4B FADS1 ACOX1 PLA2G6 ELOVL5 ACSL1 ELOVL2 FAMILIAL HYPERLIPIDEMIA TYPE 4%WIKIPATHWAYS_20260510%WP5111%HOMO SAPIENS Familial hyperlipidemia type 4 APOA5 GCK LIPC LPL PDIA2 APOA4 SEL1L PLTP LMF1 LDLR ACSS1 GPIHBP1 MTTP DGAT2 GCKR APOA2 FAS APOC2 NOD LIKE RECEPTOR NLR SIGNALING%WIKIPATHWAYS_20260510%WP288%HOMO SAPIENS Nod like receptor NLR signaling EPHB2 IKBKB MAP3K7 ERBIN CHUK RELA IKBKG MAPK8 CD40 LIPID METABOLISM IN SENESCENT CELLS%WIKIPATHWAYS_20260510%WP5149%HOMO SAPIENS Lipid metabolism in senescent cells PLA2G12A PLA2G4F PLA2G12B PLA2G4D PLA2G4E PLA2G4C PTGS2 PLA2G1B CDKN1A PLA2G2D SLCO2A1 PLA2G5 PLA2G10 ALOX5 PLA2G3 PLA2G6 PLA2G7 HRAS HUNGER AND SATIETY%WIKIPATHWAYS_20260510%WP5445%HOMO SAPIENS Hunger and satiety MC4R NPY GCG AgRP PYY GHRL POMC LEP TGFB SMAD SIGNALING%WIKIPATHWAYS_20260510%WP5382%HOMO SAPIENS TGFB Smad signaling WWTR1 POSTN TGFBR2 TGFBR3 CTGF SMAD2 SMAD4 SPARC YWHAG TGFBR1 LUNG PATHOLOGY OF COVID 19%WIKIPATHWAYS_20260510%WP5146%HOMO SAPIENS Lung pathology of COVID 19 MITA CCL2 TNF CSF2 IRF3 MAVS IL6 TLR7 CXCL11 TLR3 RIGI IL1B CXCL9 TLR8 CGAS NFKB1 IL18 IFIH1 TBK1 OXIDATIVE STRESS RESPONSE%WIKIPATHWAYS_20260510%WP408%HOMO SAPIENS Oxidative stress response MAPK10 HMOX1 MGST1 UGT1A3 TXN2 CYBB NQO1 MAPK14 CYP1A1 NFKB1 SP1 MAOA HEL-S-44 GPX1 GPX3 TXNRD2 GSTT2 XDH NOX3 NFE2L2 NOX5 JUNB HEL-75 GCLC FOS NOX4 NEUROINFLAMMATION AND GLUTAMATERGIC SIGNALING%WIKIPATHWAYS_20260510%WP5083%HOMO SAPIENS Neuroinflammation and glutamatergic signaling CREB1 GLS IL1R1 IL12B SHMT1 IL1A MAPK3 IL12A TGFB1 DLD SMAD2 SMAD4 IL10RB IL10RA FGF2 BCL2 PLCB4 PIG59 TNFRSF1B HEL-S-15 GRIN3B GRIN3A PDHA1 IGF1 PPP1CC SLC1A3 DLAT TGFBR3 ARC GLS2 MAPK1 NFKB1 TRAF5 IL13RA1 GRIA2 NGF PRKCB PRKCA CNTF GRIN2B IRS1 IL1R2 TNFRSF1A GRIN1 SLC1A1 SLC1A2 NELF SLC38A3 GRIA4 DAO SLC6A9 GRIK5 GRIK3 GRIK1 LTA LRRC8C LRRC8D SLC17A6 SLC17A7 LRRC8E IL13 HEL-S-80p IL10 PLCB1 JAK1 GRM2 STAT1 IL6ST GRM4 GRM8 IFNGR1 IL6R TGFBR1 CALM1 IFNG DISC1 SOCS3 LIF IL4 PLCB3 GFAP CAMK2D CAMK2A ADCY3 ADCY1 ADCY8 INSR STAT3 SRR GRIA3 PSAT1 PHGDH HEL-S-51e PSPH CAMK2G GRIK2 IL1B CAMK4 CAMKK1 PLCB2 CAMKK2 SLC7A10 TNF BDNF TGFBR2 SLC1A4 IL6 SLC2A3 SLC38A1 NFKB2 IFNGR2 SLC38A5 FOS ETHER LIPID BIOSYNTHESIS%WIKIPATHWAYS_20260510%WP5275%HOMO SAPIENS Ether lipid biosynthesis FAR1 UGT8 PEX16 LPCAT1 PEDS1 ALDH3A2 GNPAT PEX7 PEX5L DHRS7B AGMO CEPT1 AGPS ACAD10 LPIN2 PEX3 LPIN3 PEX19 LPIN1 AUTOPHAGY IN PANCREATIC DUCTAL ADENOCARCINOMA%WIKIPATHWAYS_20260510%WP5331%HOMO SAPIENS Autophagy in pancreatic ductal adenocarcinoma STAT3 HMGB1 PARK2 MDM2 KRAS PINK1 VMP1 SHOC2 SQSTM1 IPO8 DKFZp762B153 NFE2L2 AGER NFKB1 TFEB PARTHANATOS CELL DEATH SIGNALING PATHWAY%WIKIPATHWAYS_20260510%WP5585%HOMO SAPIENS Parthanatos cell death signaling pathway AIFM1 PARP1 MIF EFFECT OF PROGERIN ON GENES INVOLVED IN PROGERIA%WIKIPATHWAYS_20260510%WP4320%HOMO SAPIENS Effect of progerin on genes involved in progeria MTA3 MBD3 SUV39H1 H3F3B H3C15 MBD2 CHD4 HDAC2 LEF1 RBBP7 HDAC1 HEL25 KDM1A CBX1 RB1 CHD3 CBX3 RBBP4 MTA2 H3C8 GABA RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP4159%HOMO SAPIENS GABA receptor signaling GABRA3 ABAT GABBR2 GABBR1 SLC6A1 GABRG3 AP2S1 AP2M1 GABRG2 SLC32A1 GABRG1 GAD1 GAD2 SLC6A11 ALDH9A1 GPHN GABRB3 GABRB2 GABRB1 AP2A1 AP2A2 GABRE GABRQ GABRA2 GABRP GABRA6 GABRA5 GABRA4 ULTRACONSERVED REGION 339 MODULATION OF TUMOR SUPPRESSOR MICRORNAS IN CANCER%WIKIPATHWAYS_20260510%WP4284%HOMO SAPIENS Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer CCNE2 GLYCEROLIPIDS AND GLYCEROPHOSPHOLIPIDS%WIKIPATHWAYS_20260510%WP4722%HOMO SAPIENS Glycerolipids and glycerophospholipids CRLS1 DGKZ AGPAT4 GPAM GPAT4 DGAT1 PEMT PNPLA3 PTDSS2 PTDSS1 CHKB PLA2G1B PCYT2 CDIPT ETNK1 DGAT2 PNPLA2 CDS1 PISD FOXP3 IN COVID 19%WIKIPATHWAYS_20260510%WP5063%HOMO SAPIENS FOXP3 in COVID 19 IL2RA STAT5B STAT3 IL6 IL7R CD80 IL6ST IL2RG IL2RB IL2 FOXP3 IL6R EBOLA VIRUS INFECTION IN HOST%WIKIPATHWAYS_20260510%WP4217%HOMO SAPIENS Ebola virus infection in host EP300 TLR4 TIAM1 RELA MAPK3 TFAP2A ARHA ACTG1 ACTN1 IQGAP1 PIK3CA HLA-A HLA-DRB1 FLNA HLA-B PS1TP5BP1 HLA-C HLA-F HLA-E ITGA1 MAPK1 NFKB1 HAVCR2 CDC42 MBL2 RELB TYRO3 MFGE8 ADAM17 RFC1 ITGA4 CREBBP RAB5A VPS4A HLA-G PIK3CD STAT1 IGF1R HLA-DRA MERTK AXL CLEC4M HLA-DMB CLEC10A ICAM2 NPC1 ICAM3 HLA-DOA SOCS3 NPC2 HLA-DOB HLA-DMA KPNA1 VPS18 CLTC RASA2 CD300A VPS33A ACTN4 CLTB TIMD4 TSG101 IL4 CLTA CLTCL1 VPS11 RAB7A HLA-DQA2 HLA-DQA1 VPS16 HLA-DRB5 CAV3 CAV2 ITGB3 EGFR BST2 CD209 ITGA6 CLEC6A EIF2AK2 ASGR1 ITGAV HAVCR1 HLA-DPA1 HLA-DQB2 TBK1 HLA-DQB1 CTSL FLNB IKBKE DAB2IP PRKRA IRF3 VPS41 ITGB1 IRF7 HLA-DPB1 RAB9A RIGI REL FOLR1 EIF2S1 VAV2 C1QBP VPS39 RAC1 ITGA2 RHOB PIK3R3 PIK3R2 PIK3R1 PAK1 NEDD4 SCIN NFKB2 CAMKK2 PATHWAY%WIKIPATHWAYS_20260510%WP4874%HOMO SAPIENS CAMKK2 pathway CREB1 EP300 RELA ACACA HMOX1 SLCO3A1 MAPK3 IL15 ULK1 RPS6 DKFZp762B153 RPTOR RPS6KB1 CCND1 PCK2 KDR MAP1LC3A CCL5 EPOR CALM1 VCAM1 TSC1 SMC1A CXCL11 HIF1A SELL AQP1 CRTC2 FIS1 FASN HK2 TSPAN8 NFATC2 GCK MTOR MS4A3 HFE IFGGE IFI44L OASL ERMAP GALNT9 MAMDC2 MID1 FAM20C ERAF STIM1 SPINT1 SQSTM1 HMBS SFI1 WDR35 S100A8 PFKFB2 CAMK4 ATP10D DGIC TBXT ARHGEF7 TSPAN33 MAPK1 CAMK1 RHD RAC1 RAF1 ENHO CAMKK2 CYB5R3 SLC25A21 NLRP1 WFS1 CHRM3 KEAP1 MX2 ASNS ABCA1 LR8 SLC2A4 TNF TRPV4 SPIRE1 RHAG PAK1 SIRT1 C1QTNF12 CPOX CCNE1 NFE2L2 ATP1B2 SLC38A5 KLF1 PARP1 MAF MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY WITH INHIBITORS%WIKIPATHWAYS_20260510%WP4189%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway with inhibitors HMGCR MVD EXERCISE INDUCED CIRCADIAN REGULATION%WIKIPATHWAYS_20260510%WP410%HOMO SAPIENS Exercise induced circadian regulation PIGF H2BC15 CBX3 HEL-S-72p NCKAP1 CEBPB DAZAP2 CRY1 BTG1 TOB1 PURA HLA-DMA STBD1 SUMO3 UCP3 PER2 QK3 ERC2 RBPMS ZFR G0S2 PER1 ETV6 CLDN5 PSMA4 AAG1 IDI1 PPP1R3C KLF9 MYF6 SUMO1 GSTM3 HEL-S-22 VAPA CRY2 NR1D2 ECTODERM DIFFERENTIATION%WIKIPATHWAYS_20260510%WP2858%HOMO SAPIENS Ectoderm differentiation ARHGAP15 ZBTB2 SOCS2 TRPM2 RHPN1 ST8SIA4 HESX1 ZBTB7B GAS2L1 GREB1 ZFHX4 PAN2 PTPRB PPFIBP2 NUMA1 SCHIP1 LDB2 TFAP2A WDR44 SIX6 RAB8B JUP BCAS3 CAP2 PAX3 PAX6 SORCS1 BAZ1A FOXL1 SMAD4 SERPINB6 CLDN11 TOX3 ARHGAP10 ARHGEF9 KIFC3 RUTBC3 STX16 RRBP1 CTNNB1 HDAC6 TBL1X CLVS1 TTC14 C1GALT1 PTPN13 VAX2 RIT1 ZNF219 MYORG ELOVL2 BMPR1A GLI3 LHX1 HMGB2 NLGN1 ELOVL4 BOC CDON SMURF1 FZD5 MAFB FZD4 TFAP2C FZD8 CTNNA2 CTNND2 DMD FHL2 TLE5 MKS1 ARHGDIG BCOR NR1C2 MYC TNFRSF11B GLB1 CCL2 SDCBP SOX2 CTBP1 NLK NFATC1 SKIL PIM1 PLXNA2 ROR2 WNT1 RGMA ZBTB16 FYN TCF7L1 KRT6A SHH TCF3 TNLG7C UBTF BMP4 FGFR2 FOXA2 SPRY2 SNCA POU2F2 CDH8 CDH6 H2BC9 NR2F2 PRKAG2 PDE7A AHI-1 NF2 OGT HDAC10 CELSR2 KCNK10 MZF1 ASTN1 LY6E ARX GATA6 STC1 RIOK1 AND RIOK2 IN EGFR AND PI3K MEDIATED TUMORIGENESIS%WIKIPATHWAYS_20260510%WP3873%HOMO SAPIENS RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis PIK3CA PTEN MTOR EGFR AKT3 MAPKAP1 RPL11 MLST8 RIOK2 RICTOR RIOK1 FOXO3A IRON METABOLISM IN PLACENTA%WIKIPATHWAYS_20260510%WP2007%HOMO SAPIENS Iron metabolism in placenta HEPHL1 TFR2 IREB2 TF SLC40A1 MCOLN1 HEL60 SLC11A2 STEAP3 HAMP TFRC SLC25A46 PATHWAY%WIKIPATHWAYS_20260510%WP5521%HOMO SAPIENS SLC25A46 pathway EMC1 EMC2 EMC3 EMC6 EMC7 OPA1 MFN1 MFN2 APOOL MMGT1 IMMT TMEM85 COX4NB EMC10 MICOS13 MICOS10 APOO CHCHD3 CHCHD6 NRF2 PATHWAY%WIKIPATHWAYS_20260510%WP2884%HOMO SAPIENS NRF2 pathway UGT1A4 TGFB1 UGT1A3 UGT1A7 SLC39A2 SLC39A1 NQO1 SLC39A3 UGT1A1 ALDH3A1 CES3 FTL DNAJB1 PTGR1 MAFG MAFF GSTM4 GSTM3 GSTM5 SLC2A2 SLC5A1 EGR1 FGF13 SLC39A9 FTH1 SLC39A6 SLC39A5 SLC39A8 SLC6A19 SLC6A18 SLC6A17 SLC6A16 SLC6A13 HSP90AB1 HEL126 SLC5A6 SLC5A7 SLC5A8 TXN SLC5A9 CES8 EPHA3 HEL-S-10 MGST3 MGST2 SLC5A2 SLC6A20 SLC5A3 SLC5A4 SLC5A5 SLC2A9 HEL-S-128m SLC6A5 SLC6A7 SERPINA1 SRXN1 SLC2A4 SLC2A6 SLC6A2 SLC2A7 SLC2A8 SLC6A8 ME1 CYP4A11 SLC2A14 GSTA4 SLC2A11 GSTA3 SLC2A10 ABCC5 SLC2A13 SLC2A12 HEL-S-25 SLC39A11 SLC39A10 SLC39A13 SLC39A12 SLC39A14 SLC5A12 SLC5A10 HEL-S-22 SLC6A9 UGT2B7 SLC7A11 HMOX1 NR1C2 SLC6A1 AGER SLC6A11 SLC6A3 RXRA ABCC3 ABCC2 UGT1A9 EPHA2 NRG1 HBEGF TGFA HGF SQSTM1 ADH7 CYP2A6 KEAP1 CES2 TGFBR2 CES1 GPX2 SLC2A3 TXNRD3 GPX3 GSTM2 GSTM1 GSTT2 NFE2L2 HEL-75 GCLC GSTA5 GCLM HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP313%HOMO SAPIENS Hepatocyte growth factor receptor signaling STAT3 ITGB1 HGF GRB2 MAPK8 MAP4K1 MAPK3 ITGA1 RAPGEF1 PTEN PTK2B MAPK1 DOCK1 RAF1 HRAS MAP2K2 PAK1 PTGS2 CRKL PTPN11 SOS1 MET PXN RAP1A JUN PIK3CA SRC CRK MAP2K1 FOS CELL LINEAGE MAP FOR NEURONAL DIFFERENTIATION%WIKIPATHWAYS_20260510%WP5417%HOMO SAPIENS Cell lineage map for neuronal differentiation SHANK1 GLS 5HT1A HES1 PAX3 PAX6 SNAP25 UNC13A CLDN11 SYP PECAM1 TH AP2A1 AP2A2 PIG59 ACHE TNC ROBO1 GATA4 LHX1 CNP SLC1A3 ERAS NLGN1 KLF4 FGF7A SLC6A5 SLC6A2 NEF3 MIXL1 SOX9 NEFL TWIST2 RIMS2 HOMER3 HOMER1 BSN GRIN2B RBFOX3 TWIST1 GRIN1 MSX2 DLG4 FBXO15 SLC1A2 CASK SHANK3 TBR1 TPH1 SNAI2 LIN7A FUT4 SLC6A9 MAP2 ChAT DLG2 HES5 FEV OLIG2 SOX10 CD24 NODAL PCLO SLC17A6 SOX17 ERC1 SLC17A7 SLC18A3 FOXD3 DPPA2 DCX GLRA1 GLRA2 GLRA3 CACNG2 HES3 KCNJ6 MOG S100B GLRB GABBR2 RIMBP2 GABBR1 SLC6A1 GAD1 GAD2 ADRA2C HTR5A ADRA2B ADRA2A SLC6A3 GPHN MSX1 CD34 AQP4 SOX2 LMX1B POU5F1 LEF1 GFAP DPPA3 ZFP42 CSPG4 ITGA6 NGFR CDH2 ITGB1 BMP4 FOXA2 SNAI1 TBXT MBP NOTCH1 TPM1 HOMER2 NR2A1 ESRRB GATA6 DISORDERS IN KETONE BODY SYNTHESIS%WIKIPATHWAYS_20260510%WP5175%HOMO SAPIENS Disorders in ketone body synthesis BDH1 OXCT1 ACAT1 HMGCL MRNA VACCINE ACTIVATION OF DENDRITIC CELL AND INDUCTION OF IFN 1%WIKIPATHWAYS_20260510%WP5187%HOMO SAPIENS mRNA vaccine activation of dendritic cell and induction of IFN 1 TNFRSF11A IRF3 MAVS IRF7 TLR8 TLR7 MR1 TLR3 RIGI IFIH1 BIOGENIC AMINE SYNTHESIS%WIKIPATHWAYS_20260510%WP550%HOMO SAPIENS Biogenic amine synthesis PNMT ChAT DDC TH MAOA HDC ASMT ACHE DBH AANAT PAH GAD1 GAD2 TPH1 GPR40 ROLE IN INSULIN SECRETION%WIKIPATHWAYS_20260510%WP3958%HOMO SAPIENS GPR40 role in insulin secretion PLCB3 PLCD3 PKD1 GNA11 PLCL1 PLCH1 PLCB2 FFAR1 PLCE1 PLCG2 PLCG1 PLCB1 GLYCOSYLPHOSPHATIDYL INOSITOL ANCHOR PATHWAY%WIKIPATHWAYS_20260510%WP5505%HOMO SAPIENS Glycosylphosphatidyl inositol anchor pathway PGAP1 PIGO PGAP2 PIGN PGAP3 GPAA1 PIGP PIGV PIGY PIGX PIGW PIGC DPM2 PIGB PIGA PIGK PIGM MPPE1 PIGL PIGH PIGF PIGS PIGU PIGT FAMILIAL HYPERLIPIDEMIA TYPE 5%WIKIPATHWAYS_20260510%WP5112%HOMO SAPIENS Familial hyperlipidemia type 5 APOA5 LIPC LPL APOA4 SEL1L PLTP APOA2 LDLR LMF1 APOC2 GPIHBP1 LNCRNA IN CANONICAL WNT SIGNALING AND COLORECTAL CANCER%WIKIPATHWAYS_20260510%WP4258%HOMO SAPIENS lncRNA in canonical Wnt signaling and colorectal cancer MACROH2A2 CSNK1A1L SOX17 CER1 CSNK2A3 CSNK2A2 CTNNBIP1 DKK2 SFRP5 CSNK2B PORCN TFAP2A HNRNPK CHD8 SOST KREMEN1 SENP2 CCND1 CXXC4 MYC NKD1 NKD2 WIF1 FOSL1 NOTUM CTNNB1 AXIN2 DKK1 CTBP1 SFRP1 NLK FRAT1 DVL1 DVL2 JUN DVL3 WNT4 TCF7L2 CDK8 LEF1 RYK AXIN1 LRP5 CSNK1E ROR1 CTBP2 ROR2 LRP6 WNT1 CSNK1A1 ATF3 TCF7L1 WNT2B CSNK2A1 FZD10 APC WNT5B WNT16 FZD1 TCF3 SFRP4 CDK6 APC2 EZH2 WNT3 WNT10B WNT10A FRAT2 FZD3 FZD2 FZD5 WNT3A WNT7B FZD7 DKK4 FZD9 WNT7A FZD8 RUVBL1 GSK3B CCND3 MAP3K7 CCND2 PLATELET MEDIATED INTERACTIONS WITH VASCULAR AND CIRCULATING CELLS%WIKIPATHWAYS_20260510%WP4462%HOMO SAPIENS Platelet mediated interactions with vascular and circulating cells CCL2 VCAM1 TLR4 TLR7 CD40 TGFB1 IL1B PF4 CD40LG SELP SELPLG CCL5 SELE PURINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260510%WP4224%HOMO SAPIENS Purine metabolism and related disorders HEL-S-70p PAICS RRM2B ADSL MOCOS AOX1 AMPD1 XDH PFAS PNP APRT TPMT DGUOK ADA IMPDH1 HPRT1 ADSS SEROTONIN RECEPTOR 2 AND ELK SRF GATA4 SIGNALING%WIKIPATHWAYS_20260510%WP732%HOMO SAPIENS Serotonin receptor 2 and ELK SRF GATA4 signaling MAP2K2 RASGRF1 HTR2A NRAS MAPKAPK2 KRAS MAPK3 HTR2B MAPK1 RAF1 MAP2K1 GATA4 HRAS PARKINSON 39 S DISEASE PATHWAY%WIKIPATHWAYS_20260510%WP2371%HOMO SAPIENS Parkinson 39 s disease pathway GPR37 UBE2G1 APAF1 UBE2G2 UBE2J1 SNCAIP MAPK12 SEPT5 HTRA2 HEL-S-67p MAPK11 EPRS1 SYT11 PARK2 CCNE2 PINK1 HEL-117 UBB SNCA MAPK14 CYCS MAPK13 SLC6A3 DDC TH CASP6 CASP2 UBE2J2 CASP9 CCNE1 CASP3 UBA7 LRRK2 UBE2L6 ATXN2 INTEGRATED CANCER PATHWAY%WIKIPATHWAYS_20260510%WP1971%HOMO SAPIENS Integrated cancer pathway CHEK1 MRE11A BBC3 CASP8 CDC25B BRCA1 MSH2 MDM2 NOXA1 MSH6 CDKN1A ATF1 JAK1 CDK4 PTEN STAT1 BARD1 BLM SMAD2 MYC PLK1 CDC2 CDK2 BCL2 ATR BAD POU2F1 BAX CASP9 CDKN1B BACH1 CASP3 ATM RB1 MAP3K5 CDKN2B RAD50 CHEK2 OSTEOCLAST SIGNALING%WIKIPATHWAYS_20260510%WP12%HOMO SAPIENS Osteoclast signaling TNFRSF11A CTSK TNFSF11 ATP6V1G1 IFNAR1 GPR68 SPP1 AIMP2 TRPV5 ACP5 MAPK8 IFNB1 ITGB3 TNFRSF11B ONCOSTATIN M SIGNALING%WIKIPATHWAYS_20260510%WP2374%HOMO SAPIENS Oncostatin M signaling CREB1 RELA JAK3 MAPK9 MAPK8 JAK1 MAPK3 STAT5B JUND STAT1 RPS6 IL6ST MAPK14 OSMR TYK2 HRAS MAP2K2 CDK2 HIF1A SOCS3 SOS1 PXN SHC1 SRC STAT3 EGR1 MTOR KRAS GRB2 NFKBIA PTK2B MAPK1 RAF1 NFKB1 CEBPB PIK3R1 OSM PTPN11 RICTOR PRKCH VEGFA PRKCB PRKCE CDKN1B PRKCA CASP3 JUNB IRS1 MAP2K1 FOS BENZENE METABOLISM%WIKIPATHWAYS_20260510%WP3891%HOMO SAPIENS Benzene metabolism MPO GSTM1 NQO1 EPHX1 DHDH CYP2E1 HFE EFFECT ON HEPCIDIN PRODUCTION%WIKIPATHWAYS_20260510%WP3924%HOMO SAPIENS Hfe effect on hepcidin production HFE HFE2 TMPRSS6 ID1 HAMP BMP6 MECHANOREGULATION AND PATHOLOGY OF YAP TAZ VIA HIPPO AND NON HIPPO MECHANISMS%WIKIPATHWAYS_20260510%WP4534%HOMO SAPIENS Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms YAP1 PAK4 MAPK10 ITGB1 LIMD1 PS1TP5BP1 MAPK9 MAPK8 TEAD2 TEAD3 MAP4K1 MAP4K2 MAP4K3 ACTG2 ITGB7 WWTR1 CTNNA1 SGMS1 ACTG1 CTNNB1 PAK1 ITGB6 YWHAQ TEAD4 NF2 ITGB4 SRC HEL-S-31 LATS1 ITGB3 ACTA1 ITGB5 ACTA2 ITGB8 PAK6 NUCLEOTIDE METABOLISM%WIKIPATHWAYS_20260510%WP404%HOMO SAPIENS Nucleotide metabolism OAZ1 NME2 RRM2B ADSL MTHFD2 RRM1 IMPDH1 RRM2 HPRT1 ADSS SRM DHFR POLA1 POLG EV RELEASE FROM CARDIAC CELLS AND THEIR FUNCTIONAL EFFECTS%WIKIPATHWAYS_20260510%WP3297%HOMO SAPIENS EV release from cardiac cells and their functional effects PRL ERBB4 CXCL12 KLF2 RGS16 MYB NEOVASCULARIZATION PROCESSES%WIKIPATHWAYS_20260510%WP4331%HOMO SAPIENS Neovascularization processes EPHB2 EPHB4 RELA REL NOTCH3 MAPK9 MAPK8 MAPK3 FLT4 DLL4 TGFB1 ACVRL1 MAPK1 CXCR4 SMAD2 KDR NFKB1 MMP9 TGFBR1 KITLG RELB ANGPT1 HIF1A CXCL12 SMAD1 SMAD9 KIT NOTCH1 DKFZp781O1323 NFKB2 DYRK1A INVOLVEMENT REGARDING CELL PROLIFERATION IN BRAIN DEVELOPMENT%WIKIPATHWAYS_20260510%WP5180%HOMO SAPIENS DYRK1A involvement regarding cell proliferation in brain development CREB1 REST HES5 HES1 RPTOR DEPTOR CCND1 MLST8 FGF2 TSC2 TSC1 EIF2B5 RBL2 AKT1S1 RBL1 NEUROG2 TFDP1 NFATC1 TFDP2 PSEN1 FOXO1 E2F4 E2F5 DNER CRY2 RBBP4 DYRK1A CSNK1A1 MTOR H3F3B CDK6 LIN54 GMNN CDK4 LIN52 PSENEN TFDP3 DCAF7 AMPH LIN37 SPRY2 LIN9 TFAP4 SIRT1 NOTCH1 APP GSK3B CASP9 CDKN1B CASP3 LATS2 BACE1 APOPTOSIS%WIKIPATHWAYS_20260510%WP254%HOMO SAPIENS Apoptosis DIABLO MCL1 APAF1 LTA BBC3 TNFSF10 CASP8 RELA BCL2L11 TNFSF6 FADD BCL2L1 BOK IRF1 IGF1R MYC FAS IGF2 CYCS BCL2 IRF4 TNFRSF10B MAP2K4 TNFRSF1B JUN IGF1 IRF3 MAPK10 NFKBIB IRF7 CDKN2A MDM2 TP63 NFKBIE BIRC5 TP73 TRAF1 IKBKB BIRC3 NFKBIA MAP3K1 CHUK TRADD HRK PRF1 IKBKG CASP4 HELLS SCAF11 NFKB1 IRF2 TNFRSF25 TNFRSF21 CASP10 CRADD BCL2L2 TNF TRAF2 PIK3R1 TRAF3 IRF6 CASP6 BIRC2 CASP2 BAK1 DFFB RIPK1 BAD DFFA PMAIP1 BNIP3L BAX CASP9 CASP3 TNFRSF1A MIRNA REGULATION OF PROSTATE CANCER SIGNALING%WIKIPATHWAYS_20260510%WP3981%HOMO SAPIENS miRNA regulation of prostate cancer signaling MTOR PDGFA MDM2 KRAS KLK3 GRB2 CDKN1A CREBBP NFKBIA CCND1 MAPK1 IKBKG RAF1 AKT3 NFKB1 MAP2K2 BCL2 CTNNB1 BAD SOS1 GSK3B PIK3CA CASP9 CDKN1B FOXO1 MAP2K1 NOVEL INTRACELLULAR COMPONENTS OF RIG I LIKE RECEPTOR PATHWAY%WIKIPATHWAYS_20260510%WP3865%HOMO SAPIENS Novel intracellular components of RIG I like receptor pathway MAPK12 MAPK11 CASP8 RELA FADD MAPK9 MAPK8 MAPK14 ATG5 IFNG ATG12 CXCL12 IFNA1 IFIH1 TBK1 IKBKE IRF3 MAPK10 NFKBIB IRF7 RIGI IKBKB NFKBIA MAP3K1 CHUK TRADD TRAF6 IKBKG NLRX1 NFKB1 MAPK13 DHX58 TRIM25 CASP10 MITA DDX3Y TNF OTUD5 TRAF2 DDX3X MAVS AZI2 SIKE1 TRAF3 RNF125 IFNE TANK IFNK CYLD RIPK1 SNW1 PIN1 IFNB1 TBKBP1 CXCL8 MAP3K7 ISG15 TYPE II INTERFERON SIGNALING%WIKIPATHWAYS_20260510%WP619%HOMO SAPIENS Type II interferon signaling IRF9 HLA-B NOS2 JAK1 SPI1 IL1B CXCL9 STAT1 IRF1 CYBB H4C9 IFIT2 SOCS1 IFNGR1 IRF2 IFNA2 IFNG IRF4 SOCS3 IFNB1 PTPN11 IFI6 GBP1 STAT2 TAP1 MHC2TA IFNGR2 EIF2AK2 OAS1 ISG15 IRF8 BIOSYNTHESIS AND REGENERATION OF TETRAHYDROBIOPTERIN AND CATABOLISM OF PHENYLALANINE%WIKIPATHWAYS_20260510%WP4156%HOMO SAPIENS Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine ASMT PNMT SPR TH JDP1 MAOA PTS DBH AANAT PAH DHFR GLIOBLASTOMA SIGNALING%WIKIPATHWAYS_20260510%WP2261%HOMO SAPIENS Glioblastoma signaling EP300 MAP2K3 BRCA2 MAP2K5 PRKCZ CDKN1A PLCG2 FOXO3A PLCG1 MAPK3 PTEN PIK3CD IGF1R BRAF CCND1 AKT3 HRAS PDGFRA MAP2K2 CDK2 TSC2 TSC1 MAP2K4 MET PDPK1 PIK3CA SRC RB1 EGFR FOXO1 CBL CDKN2B ERBB3 CDKN2C BRCA1 CDKN2A MDM2 KRAS GRB2 MSH6 CDK6 CDK4 FGFR2 FOXO4 FGFR1 ARAF SPRY2 MAPK1 RAF1 MAP2K6 PIK3R2 PIK3R1 NRAS NF1 MDM4 PRKCH PRKCB CDKN1B PRKCA ERRFI1 CCNE1 ATM IRS1 PIK3C2G PRKCI PIK3C2A MAP2K1 CCND2 PIK3C2B PRKCQ ERBB2 SOMATROPH AXIS GH AND ITS RELATIONSHIP TO DIETARY RESTRICTION AND AGING%WIKIPATHWAYS_20260510%WP4186%HOMO SAPIENS Somatroph axis GH and its relationship to dietary restriction and aging PTEN MTOR IGF1R SIRT1 FOXO1 INHIBITION OF GNAQ REGULATED SIGNALING IN UVEAL MELANOMA%WIKIPATHWAYS_20260510%WP5490%HOMO SAPIENS Inhibition of GNAQ regulated signaling in uveal melanoma YAP1 TRIO MTOR PKN3 PKN2 PKN1 TEAD2 TEAD3 PLCB1 PIK3CD MAPK1 ROCK1 AKT3 PLCB2 ARHA PIK3R3 PIK3R2 PIK3R1 TSC2 TSC1 PLCB4 MOB1A TEAD4 PLCB3 PIK3CA LATS1 LATS2 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260510%WP47%HOMO SAPIENS Hedgehog signaling ADRBK1 SUFU KIF7 IHH PTCH2 SAP18 SIN3A SHH PTCH1 DHH GLI3 SMO OSTEOPONTIN SIGNALING%WIKIPATHWAYS_20260510%WP1434%HOMO SAPIENS Osteopontin signaling MAPK3 IKBKB CHUK RELA ITGB3 SPP1 MAPK1 MAP2K1 MAP3K14 ITGAV NFKB1 MMP9 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES AUTOPHAGY%WIKIPATHWAYS_20260510%WP4863%HOMO SAPIENS Host pathogen interaction of human coronaviruses autophagy ATG10 WIPI1 MTOR ATG12 ATG16L1 ULK2 RB1CC1 ULK1 ZFYVE1 ATG16L2 PIK3R4 MAP1LC3A ATG5 ATG3 CYTOSOLIC DNA SENSING PATHWAY%WIKIPATHWAYS_20260510%WP4655%HOMO SAPIENS Cytosolic DNA sensing pathway CASP8 RELA FADD POLR3GL POLR3A POLR1C POLR3B POLR1D POLR3C POLR3D POLR3E POLR3F POLR3G POLR3K CCL5 POLR2F ATG5 CCL4 POLR2H POLR2K POLR2L ATG12 RIPK3 IFNA1 IF1AA9 CGAS TBK1 IKBKE IFNA13 IFNA14 IRF3 NFKBIB IFNA16 IRF7 CCL4L2 IFNA17 RIGI IFNA10 IFNA21 IKBKB IL1B NFKBIA CHUK TRADD IKBKG IL33 NLRX1 IFNA4 NFKB1 IFNA7 IL18 IFNA6 IFNA2 TRIM25 IFNA8 CASP10 MITA POLR3H PYCARD MAVS IL6 RNF125 CYLD RIPK1 IFNB1 ADAR ZBP1 AIM2 TREX1 ISG15 6Q16 COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5400%HOMO SAPIENS 6q16 copy number variation INSR BDNF MC4R NPY AgRP GHRL POMC GHSR INS LEPR NTRK2 LEP SIM1 CHOLESTEROL SYNTHESIS DISORDERS%WIKIPATHWAYS_20260510%WP5193%HOMO SAPIENS Cholesterol synthesis disorders DHCR7 HMGCS1 EBP HMGCR IDI1 SC5D FDPS HSD3B2 MVK DHCR24 MSMO1 SQLE PMVK MVD FDFT1 CYP51A1 LBR CELL INTERACTIONS IN PANCREATIC CANCER MICROENVIRONMENT%WIKIPATHWAYS_20260510%WP5284%HOMO SAPIENS Cell interactions in pancreatic cancer microenvironment BAG3 CSF2 CTLA4 NRP1 CSF1 TNFSF6 CCR2 CCR5 TGFB1 HLA-DRA CXCR4 FAS KDR CCL5 CXCR3 CCL2 LAG3 CXCL12 ITGB6 CSF2RA CSF1R VEGFA CD80 HLA-DRB1 IFITM2 CHOLESTEROL BIOSYNTHESIS PATHWAY IN HEPATOCYTES%WIKIPATHWAYS_20260510%WP5329%HOMO SAPIENS Cholesterol biosynthesis pathway in hepatocytes PLPP6 ELOVL4 CYP46A1 MSMO1 TM7SF2 ABCG1 NR1H3 LBR CYP7A1 ABCA1 MYLIP HMGCS1 ELOVL5 ACSL1 ELOVL2 HSD17B7 CH25H EBP ELOVL3 HMGCR IDI1 SC5D ACSL3 FADS2 FDPS CYP27A1 MVK SCD GGPS1 IDI2 ACAT2 DHCR24 PMVK NR1H2 MVD FDFT1 CYP51A1 TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20260510%WP465%HOMO SAPIENS Tryptophan metabolism TPH2 AADAT HAAO IL4I1 IDO1 TDO2 AFMID AOC1 KYAT3 KYNU KYAT1 KMO IDO2 ALDH8A1 ECHS1 ASMT STAT1 AHR DLD AANAT ALDH2 CYP1A1 DDC MAOA GOT2 AOX1 INMT ACAT1 TPH1 GCDH T CELL MODULATION AND DESMOPLASIA IN PANCREATIC CANCER%WIKIPATHWAYS_20260510%WP5078%HOMO SAPIENS T cell modulation and desmoplasia in pancreatic cancer LGALS9 CTLA4 IDO1 PDGFD PDGFC PDCD1 PDGFA SHH TNFSF6 VTCN1 VSIR IL13 TIGIT IL10 B2M TNFRSF9 FAP TGFB1 CD226 CCL17 ICOS CD40LG CCL22 CXCR4 TNFRSF4 FAS TNLG5A ARG1 VEGFB NT5E NR1i1 HAVCR2 IL6 VEGFD CXCL12 TNLG2B CD40 ENTPD1 IL4 VEGFA PDCD1LG2 VEGFC HLA-A CD80 FLUOROACETIC ACID TOXICITY%WIKIPATHWAYS_20260510%WP4966%HOMO SAPIENS Fluoroacetic acid toxicity ACSS2 ACO2 ALDH2 ALDH3A2 CS ALDH9A1 COPPER METABOLISM%WIKIPATHWAYS_20260510%WP5189%HOMO SAPIENS Copper metabolism ATP7B ATP7A SLC31A1 SLC11A2 GLUCURONIDATION%WIKIPATHWAYS_20260510%WP698%HOMO SAPIENS Glucuronidation UGT2B11 UGT2B7 UGT2B15 UGT2B17 UGT1A10 UGT2B28 UGT1A8 UGT1A5 UGT1A9 UGT2A2 UGT2A1 UGT1A4 UGT1A3 UGT1A7 UGT2B10 UGDH PGM3 PGM2 PGM5 UGT1A1 UGT2B4 FLAVAN 3 OL METABOLIC PATHWAY%WIKIPATHWAYS_20260510%WP4238%HOMO SAPIENS Flavan 3 ol metabolic pathway MIR 222 IN EXERCISE INDUCED CARDIAC GROWTH%WIKIPATHWAYS_20260510%WP3938%HOMO SAPIENS miR 222 in exercise induced cardiac growth CDKN1B HMBOX1 HIPK1 HIPK2 DISORDERS OF FRUCTOSE METABOLISM%WIKIPATHWAYS_20260510%WP5178%HOMO SAPIENS Disorders of fructose metabolism GLYCTK SLC2A2 HEL-S-49 PFKL SLC5A1 ALDOB G6PC1 HEL-S-53e KHK SORD FBP1 INTERACTIONS OF NATURAL KILLER CELLS IN PANCREATIC CANCER%WIKIPATHWAYS_20260510%WP5092%HOMO SAPIENS Interactions of natural killer cells in pancreatic cancer CSF2 BMI1 TIGIT CCL1 CD226 NCR1 NCR3 PRF1 MYC FCGR3A KLRK1 CCL5 NCR3LG1 CCL4 MICB CCL3 CD96 CCL2 IFNG TNF MICA FOXO1 ADAM10 GATA2 ADAM17 13Q12 OR CRYL1 COPY NUMBER VARIATION %WIKIPATHWAYS_20260510%WP5405%HOMO SAPIENS 13q12 or CRYL1 copy number variation HEL30 COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260510%WP558%HOMO SAPIENS Complement and coagulation cascades C1R CFI C5AR1 C4B_2 C2 C6 PLAT C7 C9 CD55 HEL-S-62p C1QC THBD VWF SERPINF2 F5 F8 CPB2 SERPINC1 TFPI LMAN1 CLTC F2R SERPIND1 PLAUR KLKB1 F7 PLG F3 HEL-S-78p KNG1 BDKRB1 F13B F2 PROS1 CLU C8G SERPINA1 C3AR1 F9 PROC CR2 F10 CR1 SERPING1 MASP2 C1QA MASP1 CD46 CFD C1QB C1S CFH HORMONAL CONTROL OF PUBERTAL GROWTH SPURT%WIKIPATHWAYS_20260510%WP4194%HOMO SAPIENS Hormonal control of pubertal growth spurt GH1 GHRH GNRH1 IGF1 SST RESISTIN AS A REGULATOR OF INFLAMMATION%WIKIPATHWAYS_20260510%WP4481%HOMO SAPIENS Resistin as a regulator of inflammation RELA PLCD4 PLCG2 IL12B PLCG1 PLCB1 MAPK3 IL12A IKBKB PIK3CD NFKBIA CHUK MAPK1 MAPK14 IKBKG AKT3 PLCB2 NFKB1 PLCE1 TNF IL6 PLCB4 PLCD3 CXCL8 PLCB3 PIK3CA RETN MAPK SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260510%WP5530%HOMO SAPIENS MAPK signaling and ARTD family members MAP2K3 MAPK12 MAPK10 MAPK11 MAP3K11 MAPK9 MAPK8 MAP3K8 MAPK3 PARP14 ARAF MAP3K1 BRAF MAPK1 MAPK14 RAF1 MAP2K6 MAPK13 ATF4 MAP2K2 MAP3K10 MAP3K21 MAP2K4 TNKS MAP3K7 MAP3K5 MAP2K1 PARP1 MAP3K12 ENDOTHELIN PATHWAYS%WIKIPATHWAYS_20260510%WP2197%HOMO SAPIENS Endothelin pathways GNAI1 EDNRA EDNRB ADRB1 CAD PLCB1 GNG13 MAPK1 RAF1 GNAS GNB5 MYLK CALM1 ATP2A2 GNA15 ADRA1A COX2 MYL1 HEL-S-14 PTGIR NPY1R EDN1 RIIAD1 RAMP1 CALCA ECE1 HEL-S-7a NPY CALCRL PRKCA MAP2K1 TYPE II DIABETES MELLITUS%WIKIPATHWAYS_20260510%WP1584%HOMO SAPIENS Type II diabetes mellitus SLC2A2 INSR SLC2A4 PHKA2 TNF CACNA1A MTOR PRKCZ PDX1 MAPK8 MAFA INS-IGF2 SURF1 IKBKB SOCS4 IRS1 MAPK1 PIK3R5 NICOTINE EFFECT ON CHROMAFFIN CELLS%WIKIPATHWAYS_20260510%WP1603%HOMO SAPIENS Nicotine effect on chromaffin cells CHRNB4 CACNA1G CACNA1C CHRNA3 GLYOXYLATE METABOLISM%WIKIPATHWAYS_20260510%WP5166%HOMO SAPIENS Glyoxylate metabolism GOT2 SLC26A1 PXMP2 HAO1 AGXT HOGA1 PRODH2 HEL-S-133P DAO NUCLEOTIDE GPCRS%WIKIPATHWAYS_20260510%WP80%HOMO SAPIENS Nucleotide GPCRs ADORA2A LTB4R P2RY6 LPAR4 P2RY4 ADORA2B P2RY2 P2RY1 PHOTODYNAMIC THERAPY INDUCED NFE2L2 NRF2 SURVIVAL SIGNALING%WIKIPATHWAYS_20260510%WP3612%HOMO SAPIENS Photodynamic therapy induced NFE2L2 NRF2 survival signaling SRXN1 MAPK12 CES1 MAPK11 ABCC3 ABCC2 HMOX1 MAPK8 JUN NFE2L2 NQO1 EPHX1 ABCG2 MAPK14 GCLC GCLM HEL-S-22 MAPK13 NQO2 FOS ABCC6 KEAP1 T CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP69%HOMO SAPIENS T cell receptor signaling ZAP70 CREB1 GAB2 RELA MAPK9 GRAP2 MAPK8 MAP3K8 PLCG1 MAPK3 LCP2 CARD11 CD3G VAV3 BCL10 ICOS CD3E CD3D MAPK14 HRAS MAP2K2 LCK CRKL SOS1 NFATC1 NCK1 PDPK1 JUN SHC1 LAT CRK ATF2 CBL ITK HEL-S-81p PSTPIP1 NFATC2 RIPK2 CD8A SH2B3 FYN FYB1 REL GRB2 MAP4K1 IKBKB NFKBIA VAV1 PTK2B CHUK TRAF6 MAPK1 IKBKG RAF1 MAP3K14 WAS NFKB1 CDC42 PIK3R2 PIK3R1 PAK1 PTPN11 MAP3K7 MAP2K1 FOS PRKCQ RALA DOWNSTREAM REGULATED GENES%WIKIPATHWAYS_20260510%WP2290%HOMO SAPIENS RalA downstream regulated genes CDC42 NRAS YBX3 EXOC2 RALBP1 EXOC8 KRAS RAC1 RALA RAC3 HRAS CANONICAL NF KB PATHWAY%WIKIPATHWAYS_20260510%WP4562%HOMO SAPIENS Canonical NF kB pathway IKBKB NFKBIA CHUK RELA REL IKBKG NFKB1 NFKBIE ATM SIGNALING IN DEVELOPMENT AND DISEASE %WIKIPATHWAYS_20260510%WP3878%HOMO SAPIENS ATM signaling in development and disease CHEK1 MRE11A NBN MAPK12 MTOR MAPK11 RIF1 NHEJ1 ATMIN PPP5C CEP63 CDK5 PRKDC MAPK14 RNF168 MDC1 IKBKG RNF8 NFKB1 MAPK13 STK11 PPP2CA CDK2 ATR HMGN1 TSC2 SMC1A PPM1D RBBP8 TP53BP1 TRIM28 AURKB ATM LMNB2 HEL-S-102 ATF2 KAT5 RAD50 CHEK2 FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260510%WP143%HOMO SAPIENS Fatty acid beta oxidation GPD2 LIPF DECR1 CHKB CRAT ECHS1 ACSS2 DLD CPT1A ACSL6 ACSL5 HEL-S-49 LIPE CPT2 LIPC LPL ACADM ACSL1 FACL4 ACSL3 ACADVL PNPLA2 ACADL HADHB SLC25A20 ACADS ACAT1 GCDH HIPPO SIGNALING REGULATION%WIKIPATHWAYS_20260510%WP4540%HOMO SAPIENS Hippo signaling regulation YAP1 PRKAA2 CDH11 PRKCZ FLT1 PLCB1 FLT3 FLT4 IGF1R SMAD2 KDR GNAS ARHA PDGFRA WWTR1 CTNNB1 PRKACG PLCB4 KIT TEAD4 MET EPHA2 PLCB3 CSF1R TCF7L2 LEF1 EGFR GNAI3 NTRK1 NGFR NTRK2 INSR CDH2 TCF7L1 MTOR GNA11 TEAD2 FGFR4 TEAD3 FGFR3 FGFR2 FGFR1 PRKAB2 PRKAB1 RAC1 CDH17 PRKD3 PLCB2 CDH9 CDH8 CDH6 CDC42 CDH4 PRKAG1 GNAL PRKAG2 CDH24 PRKAG3 PRKAA1 NF2 PRKCH PRKCB PRKCE PRKCA LATS1 LATS2 CDH10 PRKCI CDH12 PRKAR1B CDH15 CDH16 PRKAR1A CDH18 CDH19 PRKCQ TYROSINE KINASE INHIBITORS IN GLIOBLASTOMA%WIKIPATHWAYS_20260510%WP5494%HOMO SAPIENS Tyrosine kinase inhibitors in glioblastoma EGF STAT3 TSC2 TSC1 MTOR NRAS RHEB JAK3 KRAS GRB2 SOS1 SOS2 JAK1 PTEN EREG BTC RPTOR RAF1 TGFA AKT3 TYK2 HRAS CANONICAL AND NON CANONICAL TGF B SIGNALING%WIKIPATHWAYS_20260510%WP3874%HOMO SAPIENS Canonical and non canonical TGF B signaling TGFBR2 MAPK9 MAPK8 BMP1 LOXL4 LOX LOXL1 LOXL2 TGFB1 BMPR1A BMPR2 MAPK14 SMAD2 SMAD4 GREM1 TGFBR1 AMINO ACID TRANSPORT DEFECTS IEMS %WIKIPATHWAYS_20260510%WP5029%HOMO SAPIENS Amino acid transport defects IEMs SLC3A2 SLC7A7 SLC36A2 CLTRN SLC7A9 SLC3A1 SLC6A20 SLC1A1 SLC6A19 KCNQ2 AND KCNQ3 RELATED EPILEPSY%WIKIPATHWAYS_20260510%WP5599%HOMO SAPIENS KCNQ2 and KCNQ3 related epilepsy FGF13 FGF12 DAG1 RAB11A RAB1A ZNF547 TRAPPC3 SNAP25 PRRT2 GIGYF1 TRAPPC6B SCN8A KCNQ5 STX1A SCN2A SCN4B CALM1 AKAP5 VAMP2 NEDD4 KCNQ2 KCNQ3 PRKCE CAMK2A BACE1 IRON METABOLISM DISORDERS%WIKIPATHWAYS_20260510%WP5172%HOMO SAPIENS Iron metabolism disorders CYBRD1 HEPH TF CP FTH1 HFE HFE2 FTL STEAP3 UQCRFS1 TFR2 SLC40A1 SLC11A2 PANK2 HAMP TFRC OXYTOCIN SIGNALING%WIKIPATHWAYS_20260510%WP2889%HOMO SAPIENS Oxytocin signaling OXTR H19 RB E2F1 AND CDK BETA CATENIN IN COLORECTAL CANCER%WIKIPATHWAYS_20260510%WP3969%HOMO SAPIENS H19 Rb E2F1 and CDK beta catenin in colorectal cancer CDK4 CDK8 CSRP2 CTNNB1 MACROH2A1 SOX4 MED1 RB1 CCND1 PMAIP1 NAD BIOSYNTHESIS II FROM TRYPTOPHAN%WIKIPATHWAYS_20260510%WP2485%HOMO SAPIENS NAD biosynthesis II from tryptophan HAAO NMNAT1 TDO2 HEL-S-90n AFMID KYNU KMO NADSYN1 OSTEOBLAST SIGNALING%WIKIPATHWAYS_20260510%WP322%HOMO SAPIENS Osteoblast signaling COL1A1 PDGFRA TNFSF11 PTH1R BGLAP IBSP ITGB3 FGF23 SLC17A2 PTH ITGAV TNFRSF11B IMMUNE INFILTRATION IN PANCREATIC CANCER%WIKIPATHWAYS_20260510%WP5285%HOMO SAPIENS Immune infiltration in pancreatic cancer LGALS9 CSF2 REG4 IL13 IL12B IL10 IL12A TGFB1 IL1B CXCL1 CCL20 IL2 CXCL5 CCL28 CCL5 VEGFB MMP9 IL17B CCL2 IFNG TNF IL23A IL25 IL6 VEGFD CXCL12 IL4 CXCL8 VEGFA IL17F IL17D IL17C IL17A VEGFC IL5 16P13 11 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260510%WP5502%HOMO SAPIENS 16p13 11 copy number variation syndrome DCTN6 DCTN1 DCTN4 PAFAH1B1 OFD1 ABCC1 PLK1 CEP20 DISC1 GATA3 PLAG1 PCM1 ACTR1B BMERB1 NDE1 MARF1 DCP1A CEP170 ACTR10 RAP1A PLAGL1 DCP2 RAPGEF4 KIAA0753 ABCC6 BREAST CANCER PATHWAY%WIKIPATHWAYS_20260510%WP4262%HOMO SAPIENS Breast cancer pathway MRE11A NBN BRCA2 SKP1 CSNK1A1L JAG2 DLL3 HES1 MAPK3 DLL4 NCOA1 BRAF FGF2 SP1 ATR CTNNB1 FGF7 FGF8 FGF9 JUN WNT4 PIK3CA FGF20 RB1 FGF23 FGF22 FGF21 IGF1 HEY2 FGF16 FGF18 FGF10 WNT2B FZD10 WNT5B FGF8A NOTCH3 WNT16 SFRP4 CDK6 APC2 CDK4 WNT3 FGF7B WNT10B WNT10A FRAT2 FZD3 FGF7A FZD2 FZD5 MAPK1 WNT3A RAF1 WNT7B FZD7 FZD9 FGF6B WNT7A FZD8 FGF5C CETN3 ERBB2 HES5 CSNK2A3 CSNK2A2 CDKN1A CSNK2B FLT4 PTEN PIK3CD IGF1R NR3A2 RPS6KB1 RPS6KB2 CCND1 PGR MYC AKT3 HRAS MAP2K2 TNFSF11 AXIN2 KIT FRAT1 SOS1 SOS2 DVL1 DVL2 DVL3 SHC1 TCF7L2 LEF1 AXIN1 LRP5 EGFR SHC4 LRP6 SHC3 WNT1 CSNK1A1 EGF TCF7L1 MTOR CSNK2A1 APC BRCA1 KRAS FZD1 GRB2 FGFR1 ARAF POLK DDB2 SHC2 PIK3R3 PIK3R2 PIK3R1 NRAS E2F2 E2F3 NOTCH2 BAK1 GADD45B NOTCH1 GADD45A GADD45G GSK3B BAX NFKB2 ATM MAP2K1 PARP1 FOS RAD50 RAD51 RELATIONSHIP BETWEEN INFLAMMATION COX 2 AND EGFR%WIKIPATHWAYS_20260510%WP4483%HOMO SAPIENS Relationship between inflammation COX 2 and EGFR NRAS KRAS PTGER4 PTGS2 PTGER1 PTGER2 PTGER3 MAPK3 PIK3CA SRC PIK3CD BRAF EGFR MAPK1 PLA1A AKT3 HRAS EXTRAFOLLICULAR AND FOLLICULAR B CELL ACTIVATION BY SARS COV 2%WIKIPATHWAYS_20260510%WP5218%HOMO SAPIENS Extrafollicular and follicular B cell activation by SARS CoV 2 TLR4 CXCL13 BCL6 PRDM1 IL10 CRP IL12A SYK ICOS CD40LG HEL-S-62p IL-21 CXCR4 IL2 CD82 IFNG CD79A TNFSF13 IRF4 PTPRC CD19 CXCL12 SELL CD69 TBX21 IL4 GPR183 BCR FOXO1 IRF8 TNLG7A TLR7 CCR7 PDCD1 CXCR5 CCL19 IFITM1 PAX5 CCL21 IFIT2 HEL-S-72p C4A ITGAX IFNAR2 TNF MS4A1 IL6 CR2 CR1 CD40 BACH2 BLNK MFGE8 BTLA AID CD80 TMSB10 ICOSLG FCRL5 EBI3 ZEB2 CD1D SLAMF7 XBP1 MAF SH2D1A ISG15 CD22 CAFFEINE IN MYOCYTES%WIKIPATHWAYS_20260510%WP5603%HOMO SAPIENS Caffeine in myocytes TNNI1 TNNI2 TNNI3 MYL11 TNNC2 TPM3 MYH1 HEL-S-108 TNNT3 MYH8 MYH4 PS1TP5BP1 MYH7 MYL6 TNNT1 TNNC1 ACTG2 RYR1 ACTG1 RYR2 RYR3 MYL1 MYL3 MYH6 TPM1 ACTA1 MYH2 MYL2 ACTA2 HEL-S-273 MYH13 TCA CYCLE NUTRIENT USE AND INVASIVENESS OF OVARIAN CANCER%WIKIPATHWAYS_20260510%WP2868%HOMO SAPIENS TCA cycle nutrient use and invasiveness of ovarian cancer MAPK3 JAK1 STAT3 EGFR MAPK1 HIPPO YAP SIGNALING%WIKIPATHWAYS_20260510%WP4537%HOMO SAPIENS Hippo YAP signaling WWTR1 YAP1 TNIK STK38L TEAD2 MAP4K1 TEAD3 TEAD4 MAP4K2 MINK1 NF2 HEL-S-31 LATS1 LATS2 MAP4K3 RASSF1 MALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260510%WP5320%HOMO SAPIENS Male steroid hormones in cardiomyocyte energy metabolism HSD17B3 SRD5A2 HSD17B2 HSD3B2 HSD3B1 SULT1A1 UGT1A1 CYP11A1 CYP17A1 IL10 ANTI INFLAMMATORY SIGNALING%WIKIPATHWAYS_20260510%WP4495%HOMO SAPIENS IL10 anti inflammatory signaling JAK1 STAT3 STAT1 IL6 HEL-S-10 HMOX1 IL10RB IL10 IL1A IL10RA STAT2 COLCHICINE METABOLIC PATHWAY%WIKIPATHWAYS_20260510%WP2536%HOMO SAPIENS Colchicine metabolic pathway CYP3A4 ESTROGEN SYNTHESIS AND METABOLISM%WIKIPATHWAYS_20260510%WP5276%HOMO SAPIENS Estrogen synthesis and metabolism UGT2B7 UGT1A10 SULT1E1 UGT1A8 CYP3A4 HSD17B10 CYP2C19 CYP1B1 UGT2A2 CYP2C9 CYP2C8 HSD17B7 CYP1A2 HSD17B3 HSD17B2 HSD17B1 HSD17B4 CYP3A7 SILDENAFIL TREATMENT%WIKIPATHWAYS_20260510%WP5294%HOMO SAPIENS Sildenafil treatment PARK2 PRKG1 NRF1 NOS2 GUCY1A2 ZNF746 TFAM GSK3B PDE4B PDE4A PDE4D AKT3 GUCY1B1 PPARGC1A PDE5A HEL-S-162eP JOUBERT SYNDROME%WIKIPATHWAYS_20260510%WP4656%HOMO SAPIENS Joubert syndrome TMEM231 MRE11A TTC8 TMEM17 MKS1 CETN2 B9D1 CCP110 ARR3 TMEM138 ARL2 NPHP1 INVS MYO6 PDE6A PCNT PDE6G RAB3IP TMEM237 UNC119 B9D2 CEP164 ARHA DVL1 DVL3 RAB8A KAT5 TCTN3 FLNA TCTN2 TCTN1 BBS9 BBS7 MTOR CEP97 RP2 RHEB SHH CC2D2A BBS5 BBS4 OFD1 PDE6D NPHP3 ARMC9 RPGRIP1L CEP41 NEK8 TMEM216 ATF4 SUFU CEP104 ZNF423 ARL3 PCM1 AHI-1 ARL13B TMEM67 INPP5E CEP290 PIBF1 ATM BBS2 BBS1 CPLANE1 PARP1 RAD50 UREA CYCLE AND RELATED DISEASES%WIKIPATHWAYS_20260510%WP4571%HOMO SAPIENS Urea cycle and related diseases ASL SLC25A15 NAGS SLC25A13 OTC GLS2 ARG1 ASS1 FEMALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260510%WP5318%HOMO SAPIENS Female steroid hormones in cardiomyocyte energy metabolism STK11 ESRRA SLC2A4 PPARGC1B APOB HADHB ACADM NR1C1 ACLY MTTP ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY%WIKIPATHWAYS_20260510%WP2118%HOMO SAPIENS Arrhythmogenic right ventricular cardiomyopathy CACNA1C DSG2 DAG1 CACNA1S CACNG2 ITGA4 JUP ACTN2 CACNA2D3 CACNA2D2 CACNA2D4 CACNB4 PKP2 DSC2 ACTG1 CACNA1F CTNNB1 RYR2 CACNG6 ATP2A2 CACNG7 CACNG8 CACNG1 CACNG3 ITGB6 CACNG4 CACNG5 ACTN1 ACTN4 TCF7L2 LEF1 ITGB3 ITGA6 ITGB5 CACNA2D1 ITGAV ITGB8 ITGA7 ITGA2B CDH2 ITGB1 TCF7L1 PS1TP5BP1 ITGA1 LMNA ITGA2 ITGB7 CTNNA1 CTNNA3 SLC8A1 CTNNA2 SGCD SGCA GJA1 SGCB SGCG tmp_locus_29 DMD ITGB4 EMD CACNB1 CACNB3 GLYCOSPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260510%WP5292%HOMO SAPIENS Glycosphingolipid metabolism NEU4 UGT8 UGCG ST3GAL5 GLA B3GNT5 B4GALNT1 A4GALT GBA2 A3GALT2 B3GALT2 B4GALT5 B3GALT1 B4GALT4 NEU3 INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260510%WP5120%HOMO SAPIENS Inclusion body myositis PSENEN NFKB2 PSEN2 SIRT1 PSEN1 GDF8 APP NFKB1 BACE1 CELLS AND MOLECULES INVOLVED IN LOCAL ACUTE INFLAMMATORY RESPONSE %WIKIPATHWAYS_20260510%WP4493%HOMO SAPIENS Cells and molecules involved in local acute inflammatory response TNF VCAM1 ITGB1 IL6 KNG1 IL1A C6 C7 CXCL8 ITGA4 SELP HEL-S-62p SELPLG TGIF DISRUPTION OF SHH SIGNALING%WIKIPATHWAYS_20260510%WP3674%HOMO SAPIENS Tgif disruption of Shh signaling NKX2-1 FGF8 NODAL SHH SMAD2 TGIF1 GLI3 TGIF2 FOXG1 LDLRAD4 INTRONIC SNP EFFECT ON COVID PATIENTS%WIKIPATHWAYS_20260510%WP4904%HOMO SAPIENS LDLRAD4 intronic SNP effect on COVID patients TGFBR2 NEDD4 SMAD2 ATG16L1 TMEPAI TGFBR1 NOTCH SIGNALING%WIKIPATHWAYS_20260510%WP61%HOMO SAPIENS Notch signaling NCOR1 EP300 HES5 STAT3 SKP1 MTOR NOTCH3 SAP30 HES6 JAG2 DLL3 HES1 DLL4 PSENEN PSEN2 NFKB1 FHL1 MAML1 PIK3R2 PIK3R1 LCK NUMB FBXW7 NOTCH2 NOTCH1 SNW1 GSK3B DTX1 APH1B NCOR2 MAGEA1 HDAC2 SRC CIRSR SPEN HDAC1 ITCH MAML2 PSEN1 RBPJ HEY2 ADAM17 MAML3 SULINDAC METABOLIC PATHWAY%WIKIPATHWAYS_20260510%WP2542%HOMO SAPIENS Sulindac metabolic pathway CYP1A2 MSRA MSRB2 MSRB3 CYP1B1 METABOLISM OF SPHINGOLIPIDS IN ER AND GOLGI APPARATUS%WIKIPATHWAYS_20260510%WP4142%HOMO SAPIENS Metabolism of sphingolipids in ER and Golgi apparatus B4GALT1 CERK SGMS1 SPHK1 SGMS2 UGT8 UGCG B4GALNT1 KDSR B3GALT2 SPHK2 GALNT1 SGPP2 B4GALT2 SGPP1 B3GALT1 GALNT16 SGPL1 CERS3 MEASLES VIRUS INFECTION%WIKIPATHWAYS_20260510%WP4630%HOMO SAPIENS Measles virus infection TLR4 IL2RG RELA CCNE2 JAK3 MAPK9 MAPK8 IL12B IL1A IL12A IL2 CDK2 BCL2 HEL70 TNFAIP3 JUN PIK3CA IFNA1 IF1AA9 IRAK1 IFNA13 IFNA14 NFKBIB IFNA16 IFNA17 IFNA10 IFNA21 CDK6 CDK4 IKBKB NFKBIA CHUK TRADD TRAF6 IKBKG NFKB1 IFNA4 IFNA7 IFNA6 IFNA2 IFNA8 IFNAR2 IFNAR1 IFNB1 STAT2 MX1 MAP3K7 CD46 APAF1 BBC3 CASP8 TNFSF6 CSNK2A3 FADD CSNK2A2 BCL2L1 CSNK2B JAK1 STAT5B PIK3CD CD3G STAT1 CD3E CCND1 CD3D IRAK4 FAS CYCS TYK2 CLEC4M IL2RB MYD88 IL2RA CD209 LNIR EIF2AK2 EIF2AK1 OAS1 EIF2AK4 OAS2 IFIH1 HEL-S-103 TBK1 EIF3S3 TLR9 IRF9 RCHY1 IKBKE FCGR2B STAT3 RAB9B IRF3 MAPK10 IRF7 CSNK2A1 TLR7 RAB9A RIGI EIF2S1 TP73 IL1B HEL-S-72p PIK3R3 PIK3R2 PIK3R1 MAVS IL6 TRAF3 BAK1 BAD BAX NFKB2 CASP9 CCND3 CDKN1B CCNE1 CASP3 ADAR CCND2 HSPA2 FOS LACTATE SHUTTLE IN GLIAL CELLS%WIKIPATHWAYS_20260510%WP5314%HOMO SAPIENS Lactate shuttle in glial cells LDHB HEL-76 CA4 SLC16A7 NUDT14 SLC4A4 SLC1A2 HEL-S-133P SLC16A3 SLC2A3 SUDDEN INFANT DEATH SYNDROME SIDS SUSCEPTIBILITY PATHWAYS%WIKIPATHWAYS_20260510%WP706%HOMO SAPIENS Sudden infant death syndrome SIDS susceptibility pathways CREB1 REST IL1RN EP300 TPH2 HTR2A 5HT1A IL1A HDAC9 HES1 SNAP25 FOXM1 YBX1 CHRNA7 SP1 DDC CTNNB1 TH MAOA VAMP2 SST JUN CHRNB4 HDAC1 MEF2C SLC9A3 SLC1A3 EGR1 SSTR2 NKX3-1 HEL-S-87p NFKB1 CHRM2 C4A HEL-S-162eP SCN4B HEL2 CEBPB GJA1 CHRNB2 NGF RET GRIN1 PRKAR1B PRKAR1A TPH1 MAP2 ChAT HES5 FEV C4B_2 NR3C1 IL13 IL10 AVP CREBBP RORA NR3A2 G6PC1 PAH CPT1A ASCL1 GNB3 IL6R TLX3 TF RYR2 NKX2-2 GATA3 HIF1A AQP4 SOX2 ACADM EN1 LMX1B RUNX3 YWHAQ HEL-S-1 YWHAG YWHAZ POU5F1 CAV3 HADHB DLX2 TACR1 GATA2 NTRK2 GCK VIPR2 PKNOX1 TSPYL1 PBX1 POU3F2 ADCYAP1R1 TCF3 BHLHB2 DEAF1 SCN3B TP73 SPTBN1 PHOX2B PHOX2A CTCF IL1B CC2D1A HEL-S-125m SCN5A SNTA1 NOS1AP SLC25A4 HSPD1 POU2F2 KCNJ8 NFYA GPD1L NEUROD1 CREM TNF BDNF PPARGC1B IL6 CXCL8 ECE1 VEGFA NFKB2 CASP3 FREP1 NR1A2 SP3 MYB PPARGC1A EDA SIGNALING IN HAIR FOLLICLE DEVELOPMENT%WIKIPATHWAYS_20260510%WP3930%HOMO SAPIENS EDA signaling in hair follicle development LTB EDAR WNT3 RELB SHH PTCH1 DKK1 DKK4 EDARADD TNLG7C BMP1 SOSTDC1 INTEGRIN MEDIATED CELL ADHESION%WIKIPATHWAYS_20260510%WP185%HOMO SAPIENS Integrin mediated cell adhesion MAP2K3 MAPK12 MAP2K5 ITGA4 HEL-S-28 VAV3 BRAF AKT3 MYPN HRAS TLN1 MAP2K2 ITGB6 SOS1 CAPN10 PDPK1 PXN SHC1 SRC CAV3 ITGB3 CRK CAV2 ITGA6 SHC3 ITGB5 ITGAE ITGAV ITGB8 PAK6 ITGA7 ITGA2B CAPN3 PAK4 MAPK10 ITGB1 FYN GRB2 VAV2 RAC3 ITGA1 RAPGEF1 MAPK7 RHO ARAF HEL114 ITGAM ARHGEF7 MAPK1 DOCK1 RAC1 RAF1 ROCK1 ROCK2 ITGA2 ITGB7 MAP2K6 MYLK2 CAPN9 CAPNS1 CDC42 CAPN6 ITGAX CSK CAPN7 PIK3R2 CAPN5 MAPK6 TNS1 PAK1 MAPK4 VASP GIT2 CAPN11 ZYX RAP1A ITGB4 MAP2K1 SELENOP ASPIRIN AND MIRNAS%WIKIPATHWAYS_20260510%WP4707%HOMO SAPIENS Aspirin and miRNAs VEGFA WNT1 PTGS2 NFKB1 MVD PTGS1 NR1C1 GABA AND GLUTAMATE SIGNALLING IN EPILEPTOGENESIS%WIKIPATHWAYS_20260510%WP5600%HOMO SAPIENS GABA and glutamate signalling in epileptogenesis GABRA3 MAPK3 ARHGEF9 PPP2CA AP2A1 AP2A2 PIG59 SH3GL2 HDAC1 GRIN3B GRIN3A SLC1A3 ARC GLS2 ABAT SLC6A13 MAPK1 HEL-S-162eP SLC6A8 PDIA2 GRIA2 PRKCA HOMER1 GRIN2B SUMO1 GRIN1 SLC1A1 DLG4 SLC1A2 MBD5 GRIA4 ORAI1 GRIK5 GRIK3 GRIK1 SLC7A11 GRIP1 PLCB1 CACNG2 CREBBP GRM2 STAT1 DKFZp762B153 SLC6A1 GRM4 GRM6 SLC32A1 GRM8 GAD1 FFAR1 SLC6A11 SDCBP CACNG8 NRG1 EFNB2 SRC CAMK2A CRTC1 CDH2 STAT3 GRIA3 GNA11 STIM1 GRIK2 GABRG3 GRM3 NRXN3 GABRG2 GABRG1 GABRB3 GABRB2 ERBB4 GABRB1 FRMPD3 ADARB1 SLC6A12 NETO2 CPEB3 CABIN1 GABRR3 GABRR1 NPTN ADIJ DLGAP3 ADII GABRE PICK1 NWD1 GABRQ HDAC10 SNX27 GABRA2 ATAD1 GABRP SLC12A5 SYVN1 GABRA6 LHFPL4 MAP2K1 GABRA5 SNX14 GABRA4 FRAGILE X SYNDROME%WIKIPATHWAYS_20260510%WP4549%HOMO SAPIENS Fragile X syndrome ARHGAP32 CREB1 KCNC1 DUSP3 KCND2 SHANK1 ALDH5A1 TBC1D7 EPS8L1 PTPN5 FMR1 DAG1 PLCG1 EIF4G1 CNR1 BRAF PPP2R5B CYFIP2 AP2A1 ARC CDKN2A ABAT MAPK1 RAF1 RAP1GAP GRIA2 APP EEF1A1 SYNGAP1 PRKCA DICER1 AGO2 HOMER1 TARBP2 GRIN2B GRIN1 DLG4 HCN1 PRKAR1A GRIP1 ALDH3A2 PLCB1 PTEN DKFZp762B153 RPTOR RPS6KB1 DEPTOR SLC6A1 AP2S1 AP2M1 CPT1A PPP3CA GAD1 MLST8 MAP2K2 TSC2 GPHN TSC1 TTI1 AKT1S1 EPHA4 ABCD3 CLTC CLTB SOS1 CLTA CLTCL1 SHC1 SRC CAMK2A NTRK2 FYN MTOR RHEB KRAS GRB2 ARAF CAMK4 CAMK1 GABRG2 MMP9 BDNF AKAP5 GABRB2 SH3GL3 AGAP2 PTPN11 NF1 EIF4E DLGAP3 PICK1 MAP1B MAP2K1 EIF4A1 SH3GL1 CYFIP1 GRIP2 EIF4EBP2 ENTEROCYTE CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260510%WP5333%HOMO SAPIENS Enterocyte cholesterol metabolism MSMO1 TM7SF2 CD36 LBR ABCA1 ABCG8 ABCG5 DHCR7 DGAT1 APOA4 LDLR SLC27A4 HMGCS1 SAR1B MTTP HSD17B7 EBP NPC1L1 HMGCR IDI1 SC5D MGAT1 FDPS MVK APOB ACAT2 DHCR24 FABP2 SQLE PMVK MVD FDFT1 CYP51A1 LNCRNA LIKE NMRK2 IN TRANSLOCATION RENAL CELL CARCINOMA%WIKIPATHWAYS_20260510%WP5519%HOMO SAPIENS LncRNA like NMRK2 in translocation renal cell carcinoma MDH2 NONO NMRK2 SLC19A2 FH CS SIGNALING LIPIDS%WIKIPATHWAYS_20260510%WP5584%HOMO SAPIENS Signaling lipids CYP7A1 CYP8B1 GPX4 ALOX15 PRXL2B CYP2B6 HPGD PTGS2 CYP4F2 PLA2G1B CYP2C9 PTGES LTC4S CYP2C8 PLCB1 CYP7B1 CYP27A1 FADS2 ALOX5 EPHX2 PLA1A ALOX12 LUNG FIBROSIS%WIKIPATHWAYS_20260510%WP3624%HOMO SAPIENS Lung fibrosis CSF2 FAM13A HMOX1 SFTPC RTEL1 IL13 SFTPA2 IL12B DPP9 STN1 MUC5B TIMP1 PTX3 TGFB1 SFTPA1 CCL5 FGF2 CCL4 CCL3 CCL2 FGF7 SKIL IL4 KPG_011 TGFA GREM1 IGF1 CCR3 EGF CSF3 HGF PDGFA CCR2 CCL11 IL1B ELMOD2 CMA1 CXCL2 MMP2 MMP9 BMP7 SERPINA1 TNF CEBPB CTGF IL6 SPP1 ATP11A TERT EDN1 CXCL8 MT2A CALCA NFE2L2 IL5 ATR SIGNALING%WIKIPATHWAYS_20260510%WP3875%HOMO SAPIENS ATR signaling RPA3 CHEK1 HUS1 ATR RAD9B RAD1 RPA1 ATRIP RAD9A TOPBP1 17P13 3 YWHAE COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5376%HOMO SAPIENS 17p13 3 YWHAE copy number variation HEL2 PPP2CA DCTN6 DDC DCTN5 TH DISC1 DCTN1 DCTN4 HEL-S-77 PAFAH1B1 YWHAQ CDK5 HEL-S-1 YWHAG YWHAZ DCTN3 NDEL1 DBH DYNC1H1 HEMATOPOIETIC STEM CELL DIFFERENTIATION%WIKIPATHWAYS_20260510%WP2849%HOMO SAPIENS Hematopoietic stem cell differentiation CSF2 CSF1 HES6 IL1A ACVR1B NCKAP1L IKZF1 TPO TRAF3IP3 LYL1 HMGN5 TRIM29 CXCR4 CBFA2T3 ZNF835 ABO MUC1 MXI1 EPO NFE2 RUNX1 RIOK3 XB FLI1 KITLG ARHH FOSB GP9 IL3 CD34 LMO2 GATA1 PIM1 LEF1 ITGB3 GATA2 ITGA2B NFATC2 CSF3 SPI1 IL1B VAV1 IL6 NOTCH1 MHC2TA NR1A2 KLF1 MYB IL5 FOS ENERGY METABOLISM%WIKIPATHWAYS_20260510%WP1541%HOMO SAPIENS Energy metabolism CREB1 EP300 ESRRA PRKAA2 NRF1 CAMK2G GABPA TFAM PPARG FOXO3A MEF2D PPP3R2 NR1C2 CAMK4 PPP3CC NCOA1 MED1 PRKAB2 MAPK14 PRKAB1 PPP3CA NR1C1 PPP3R1 PPARGC1B TFB1M RXRA PRMT1 UCP2 TFB2M SIRT1 PRKAG1 PPRC1 PRKAG2 SIRT3 MYBBP1A PRKAA1 PRKAG3 UCP3 GSK3B HDAC1 FOXO1 ATF2 PPARGC1A MEF2C MEF2B 22Q11 2 DISTAL CNV%WIKIPATHWAYS_20260510%WP5546%HOMO SAPIENS 22q11 2 distal CNV CHEK1 RBX1 WDR57 PTPA CANX DHX16 RNF19B SNRPA1 RPS15 RPS14 SF3B5 VPREB1 SF3B2 RPS17 RPS16 RPS19 RPS18 CWC22 ROPN1L RPS11 RPS10 RPS13 SNRPB2 RSPH6A BCR SF3B1 RPS9 AQR SF3A1 RPS7 SF3A2 RPS8 RPS5 PHF5A DNAJB13 RPSA CRNKL1 PDIA4 RAB36 DNAJB11 PPIE DYDC1 SNRNP200 UBA6 CABP1 AK8 CD79B SDF2L1 CWC15 TDRD3 RPS26 RPS28 RPS29 RSPH14 RPS20 HYOU1 RPS21 RPS24 RPS23 GGTLC2 ZNF280A IQUB MAPK1 HEL-S-107 ARIH1 CCDC116 BUD31 PLRG1 NME5 YDJC RBM22 RSPH9 PPM1F RNF113A RPS15A RPS3 RPS2 RPS27A RILP PDIA2 UGGT1 PPIL1 SOX9 CDC5L RSPH3 IGLL5 XAB2 IGLL1 YPEL1 FAU PPIL4 PPIL6 UBE3A XBP1 GNAZ ELOC PARK2 RPS6 CD79A PPIB CAMK2A CBL HEL-S-99n MDM2 HEL-S-125m HEL-S-89n CAMK4 CAMK1 SNRPD2 SNRPD1 SNRPD3 PAK1 NEDD4 SNW1 SNRPG SNRPE SNRPF LRP4 SNRPB PRPF8 ALZHEIMER 39 S DISEASE%WIKIPATHWAYS_20260510%WP5124%HOMO SAPIENS Alzheimer 39 s disease CSF1 CSNK1A1L RELA MAPK9 MAPK8 IL1A MAPK3 BRAF PSEN2 AMBRA1 CTNNB1 PLCB4 LPL PIK3CA HEL-S-61 WNT2B FZD10 WNT5B WNT16 SFRP4 APC2 WNT3 WNT10B WNT10A FZD3 FZD2 FZD5 WNT3A WNT7B FZD7 FZD9 WNT7A HEL-S-162eP FZD8 APP PSMD9 PSMD6 PSMD4 PSMD3 GRIN2B PSMD1 GRIN1 ADAM10 VDAC3 NRBF2 ATG2B IDE BACE1 PSMA2 KNS2 ADAM17 PSMA8 PSMB6 PSMB2 PSMB3 PSMC1 HEL-S-276 RTN3 GPR83 KLC4 KLC3 KLC2 NAE1 ATP2A1 SLC25A6 BECN2 ADRM1 SLC25A31 PIK3CD ULK1 AKT3 PPP3CA HRAS TUBAL3 ATG101 TUBB8 TUBA3E MAP2K2 TUBA1C TUBB6 TUBA1B TUBA1A AXIN2 TUBB1 TUBB TUBB4B TUBB4A ULK2 TUBA4A FRAT1 TUBB2A DVL1 DVL2 DVL3 TUBA2 RB1CC1 AXIN1 LRP5 TUBA8 CSNK1E PSEN1 LRP6 WNT1 EIF2AK2 CSNK1A1 INSR MTOR CSNK2A1 APC NOS2 KRAS EIF2S1 CDK5 PSENEN IL1B CALML6 ARAF KIF5A CALML3 CALML4 SNCA CDK5R1 DKK4 APOE PIK3R3 PPIF PIK3R2 PIK3R1 NRAS RTN4 BAD NOX4 CHRNA7 WIPI1 WIPI2 ATG14 DKK1 ATG2A PSMD2 SHFM1 WNT4 IRS4 PSMD7 PSMD12 PSMD13 IKBKB FRAT2 CHUK MAPK1 RAF1 NFKB1 TRAF2 PTGS2 IRS1 TNFRSF1A PIK3R4 XBP1 INS APAF1 ITPR2 CACNA1C CASP8 CSNK2A3 FADD CSNK2A2 HSD17B10 DKK2 CACNA1S PLCB1 HEL-S-91n CSNK2B PPP3R2 CYBB FAS AGER CYCS PSMC6 PSMC4 CALM1 CACNA1F ATP2A2 RYR3 MME APH1B PLCB3 DDIT3 SLC25A5 MAPK10 FZD1 PPP3CC SLC25A4 PLCB2 ATF4 PPP3R1 TNF IL6 GSK3B MCU CASP9 PSMA4 CASP12 CASP3 MAP3K5 MAP2K1 ERN1 TRANS SULFURATION PATHWAY%WIKIPATHWAYS_20260510%WP2333%HOMO SAPIENS Trans sulfuration pathway pcap CBS MTR CTH GCLM APOPTOSIS RELATED NETWORK DUE TO ALTERED NOTCH3 IN OVARIAN CANCER%WIKIPATHWAYS_20260510%WP2864%HOMO SAPIENS Apoptosis related network due to altered Notch3 in ovarian cancer RIPK2 YBX3 HEL-S-7 PKN1 CDKN1A BIRC5 BEX3 TRAF1 SQSTM1 CUL5 RNF7 VAV3 JUND NET1 PTK2B CARD14 HEL-S-89n RPS6KB1 NQO1 HEL113 HSPD1 MAPK1 THBS1 HELLS NFKB1 TNFRSF21 APOE CTNNA1 TNF TNFRSF10B SOCS3 F2R APP NRG1 CDKN1B HDAC1 AXIN1 IL7R GCLC HEL-S-102 ERBB3 ERN1 MIR 509 3P ALTERATION OF YAP1 ECM AXIS%WIKIPATHWAYS_20260510%WP3967%HOMO SAPIENS miR 509 3p alteration of YAP1 ECM axis YAP1 EDNRA TEAD2 TEAD3 TEAD4 COL1A1 COL3A1 PBX3 THBS2 GPC6 TWIST1 SPARC SNAI2 METABOLIC PATHWAY OF LDL HDL AND TG INCLUDING DISEASES%WIKIPATHWAYS_20260510%WP4522%HOMO SAPIENS Metabolic pathway of LDL HDL and TG including diseases APOE ABCA1 SCARB1 LIPC ANXA2 LPL LDLR MTTP APOB PCSK9 APOA2 APOC2 LIPG IL26 SIGNALING%WIKIPATHWAYS_20260510%WP5347%HOMO SAPIENS IL26 signaling CTSK STAT3 CSF2 RELA MAPK9 MAPK8 IL10 MAPK3 JAK1 RORC IL1B NFKBIA STAT1 EPHA3 IF2G MAPK1 MAPK14 SMAD2 CCL20 DCSTAMP IL33 DEFB4B IL20RA ATP6V0D2 IL10RB TYK2 MMP9 TNF TNFSF11 IL6 SOCS3 COX2 NFATC1 CXCL8 JUN BAX PIK3CA MPO IL17A CASP3 DDIT3 ACTA2 MYD88 DISTINCT INPUT OUTPUT PATHWAY%WIKIPATHWAYS_20260510%WP3877%HOMO SAPIENS MYD88 distinct input output pathway TLR4 TLR7 MYD88 HEL-S-71 IL1A JUN UBE2V1 TLR8 TLR5 TRAF6 TLR1 NFKB1 IRAK1 TIFA TLR10 TLR9 BIOMARKERS FOR UREA CYCLE DISORDERS%WIKIPATHWAYS_20260510%WP4583%HOMO SAPIENS Biomarkers for urea cycle disorders ASL NAGS F10 OTC HEL-S-20 GLS2 GPT ARG1 ASS1 F7 ANK2 PATHWAY IN EPILEPSY DEVELOPMENT%WIKIPATHWAYS_20260510%WP5557%HOMO SAPIENS ANK2 pathway in epilepsy development ANK2 L1CAM EIF2A CSNK2A1 SEMA3A KCNQ2 CSNK2A2 CSNK2B SCN5A SPTAN1 DDIT3 SNAP25 PRRT2 SPTBN4 SCN2A ATF4 BRSK1 CHRONIC HYPERGLYCEMIA IMPAIRMENT OF NEURON FUNCTION%WIKIPATHWAYS_20260510%WP5283%HOMO SAPIENS Chronic hyperglycemia impairment of neuron function MMP7 PRKCZ NOS2 MMP14 HEL-S-62p SNAP25 AGER MMP2 PRKD3 SCN8A MMP9 BDNF MMP21 MMP20 MMP25 MMP24 TRPA1 MMP23B MMP27 SCN9A TRPV1 MMP10 MMP11 SLC2A3 SCN10A MMP16 MMP15 MMP17 MMP19 PRKCH PRKCB PRKCE PRKCA MMP28 PRKCI MMP3 SORD MMP12 PRKCQ INITIATION OF TRANSCRIPTION AND TRANSLATION ELONGATION AT THE HIV 1 LTR%WIKIPATHWAYS_20260510%WP3414%HOMO SAPIENS Initiation of transcription and translation elongation at the HIV 1 LTR NFATC2 EP300 NELFB NELFCD RELA CDK9 SUPT5H HDAC7 HDAC3 HDAC9 PPP3R2 CREBBP NFKBIA PPP3CC PPP3CA NFKB1 HDAC5 SP1 PPP3R1 HDAC8 NFATC1 SUPT4H1 NELFA HEXIM1 HDAC2 NFATC3 HDAC1 NFATC4 CELLULAR PROTEOSTASIS%WIKIPATHWAYS_20260510%WP4918%HOMO SAPIENS Cellular proteostasis VBP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 NSP1 FROM SARS COV 2 INHIBITS TRANSLATION INITIATION IN THE HOST CELL%WIKIPATHWAYS_20260510%WP5027%HOMO SAPIENS nsp1 from SARS CoV 2 inhibits translation initiation in the host cell EIF3CL EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B EIF2S2 EIF2S1 EIF1AX SUI1 EIF5 EIF2S3 EIF3S2 EIF3J EIF3S3 EIF3G DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260510%WP707%HOMO SAPIENS DNA damage response CREB1 CHEK1 MRE11A NBN APAF1 BBC3 CASP8 CCNE2 RFC1 SFN RAD9A CDKN1A PRKDC CCNB3 CCNB2 CCNB1 CCND1 MYC FAS CYCS CDC2 CDK2 FANCD2 ATR TLK1 TNFRSF10B TP53AIP1 SMC1A ATRIP RAD17 RAD1 RB1 PML HUS1B BRCA1 PIDD1 MDM2 TLK2 CDK5 CDK6 CDK4 RRM2B DDB2 SESN1 GADD45B PMAIP1 GADD45A GADD45G BAX H2AX CASP9 RAD52 CCND3 CDKN1B CCNE1 CASP3 ATM CCND2 RAD50 CHEK2 RAD51 INTERACTOME OF POLYCOMB REPRESSIVE COMPLEX 2 PRC2 %WIKIPATHWAYS_20260510%WP2916%HOMO SAPIENS Interactome of polycomb repressive complex 2 PRC2 AEBP2 SUZ12 EZH1 EED MORC3 ELL SETX THRAP3 STK38 TRIM35 JARID2 EZH2 BCLAF1 RBBP7 RBBP4 METHIONINE DE NOVO AND SALVAGE PATHWAY%WIKIPATHWAYS_20260510%WP3580%HOMO SAPIENS Methionine de novo and salvage pathway MTR IL4I1 HEL-S-61p AMD1 APIP MRI1 TXN MAT1A MTAP ADI1 ENOPH1 MSRA MSRB2 CHDH MSRB3 SRM SMS FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20260510%WP357%HOMO SAPIENS Fatty acid biosynthesis PC ACACA DECR1 ECHS1 ACSL1 FACL4 ACSS2 PECR ACSL3 MECR SCD ACACB FASN ECHDC1 ECHDC2 ACSL6 ACSL5 ACLY INTERFERON TYPE I SIGNALING%WIKIPATHWAYS_20260510%WP585%HOMO SAPIENS Interferon type I signaling ZAP70 CREB1 EIF4B MAP2K3 GAB2 JAK1 PIK3CD STAT1 RPS6 RPTOR RPS6KB1 MAPK14 SOCS1 STAT4 MLST8 TYK2 LCK PTPRC PRMT1 SOCS3 CRKL CRK RPS6KA4 CBL EIF4EBP1 IRF9 STAT3 FYN MTOR PTPN6 REL RAPGEF1 RPS6KA5 VAV1 MAP3K1 RAC1 MAP2K6 IFNAR2 PIK3R2 PIK3R1 IFNAR1 MAPKAP1 PTPN11 STAT2 RAP1A EIF4E IRS1 EIF4A1 PIAS1 NUCLEOSOME REMODELING COMPLEX%WIKIPATHWAYS_20260510%WP5572%HOMO SAPIENS Nucleosome remodeling complex SMIM40 PRKDC CHAF1A XRCC5 MCM2 PCNA H4C9 HAT1 SUPT16H HIST1H4L SSRP1 CHAF1B ASF1A NASP ASF1B RBBP4 CHEK2 SEROTONIN RECEPTOR 4 6 7 AND NR3C SIGNALING%WIKIPATHWAYS_20260510%WP734%HOMO SAPIENS Serotonin receptor 4 6 7 and NR3C signaling CREB1 MAP2K2 EGR1 MAPKAPK2 NR3C1 ATF1 RAP1A MAPK3 RPS6KA5 BRAF HTR4 MAPK1 HTR6 HTR7 MAP2K1 GNAS NF1 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260510%WP5366%HOMO SAPIENS NF1 copy number variation syndrome MCL1 EXOC4 EXOC3 EXOC6 H3C15 EXOC5 CCNE2 SUPT5H EXOC2 RFC2 EXOC1 RAD9A RAB11A MAPK3 ARF6 ARHA BCL2 ATR CRY1 TUBB CCNA2 USP1 OMG SOS1 RTN4R PER1 HEL-S-15 PCNA EGFR NGFR SUZ12 EGF EIF3A EED RIGI RFC3 RFC4 MAP3K2 JARID2 SYN1 RBBP7 MAP3K1 H4C9 MAPK1 RAF1 HIST1H4L ROCK2 EXOC7 WDR48 HOXA9 HOXA1 POLRMT MYT1 EVL EZH1 SDC2 ADAP2 MAVS INPP5A E2F6 LIMK1 RAB11FIP4 TEFM UTP6 ATAD5 COPRS EVI2A IFNB1 CRLF3 NGF EVI2B NF1 METAP2 CCNE1 EXOC8 H3C8 RAD51 SYNAPTIC VESICLE PATHWAY%WIKIPATHWAYS_20260510%WP2267%HOMO SAPIENS Synaptic vesicle pathway SLC1A3 CACNA1B CACNA1A HEL-S-67p SLC17A6 SLC17A7 SLC18A3 SYN1 SLC25A4 NAPA AP2S1 SNAP25 AP2M1 UNC13A SLC32A1 SYT1 STXBP1 SYP STX1A CPLX1 STX1B RIMS1 SLC18A2 VAMP2 AP2A1 CLTC AP2A2 SLC38A1 CLTA SLC22A3 CLTCL1 CPLX2 CLN8 SLC17A8 STX2 SLC18A1 UNC13B UNC13C SYN2 STX3A DNM3 STRIATED MUSCLE CONTRACTION PATHWAY%WIKIPATHWAYS_20260510%WP383%HOMO SAPIENS Striated muscle contraction pathway TNNI1 TNNI2 TCAP TNNI3 TNNC2 TPM3 HEL-S-108 TNNT3 MYH8 TNNT1 TNNC1 HEL113 ACTN2 TTN ACTG1 MYL1 tmp_locus_29 ACTN4 MYL3 MYH6 TPM1 DMD ACTA1 MYOM1 MYBPC3 MYL2 TMOD1 ACTA2 MYL4 HEL-S-273 KYNURENINE PATHWAY AND LINKS TO CELL SENESCENCE%WIKIPATHWAYS_20260510%WP5044%HOMO SAPIENS Kynurenine pathway and links to cell senescence IFNG AADAT TNF HAAO TLR4 IDO1 HEL-S-90n TDO2 AFMID KLF5 KYNU KMO IDO2 IFNB1 CDKN1A AHR IL1R2 FOXO1 EIF2AK1 EIF2AK4 PROLACTIN SIGNALING%WIKIPATHWAYS_20260510%WP2037%HOMO SAPIENS Prolactin signaling ZAP70 SOCS2 PRL GAB2 RELA TEC MAPK9 MAPK8 CISH JAK1 MAPK3 STAT5B STAT1 RPS6 RPS6KB1 MAPK14 MYC SOCS1 HRAS MAP2K2 SOCS3 SOS1 YWHAG YWHAZ PXN JUN PIK3CA PPIB SHC1 SRC CBL FLNA EIF4EBP1 PTPN1 STAT3 SIRPA NFKBIB ITGB1 FYN MTOR PTPN6 GRB2 VAV2 NFKBIA VAV1 MAPK1 RAC1 RAF1 PRLR NFKB1 PIK3R2 PIK3R1 PAK1 RPS6KA2 HEL-S-130P AGAP2 PTPN11 GSK3B CASP3 IRS1 MAP2K1 HEL-S-69p FOS NEK3 ERBB2 VITAMIN B12 METABOLISM%WIKIPATHWAYS_20260510%WP1533%HOMO SAPIENS Vitamin B12 metabolism SAA4 MCEE TCN2 PLG CBLIF INSR CBS TCN1 MTR HEL-S-78p ALB RELA SAA1 SAA2 HEL-S-51e PLAT CRP IL1B F2 NFKB1 CCL5 APOE CCL2 ABCA1 IFNG TNF IL6 SCARB1 HEL-S-44 LDLR HBB HBA2 MPO MAT1A NFKB2 APOB CTH SERPINA3 INS CUBN FGA MTRR F7 TYROBP CAUSAL NETWORK IN MICROGLIA%WIKIPATHWAYS_20260510%WP3945%HOMO SAPIENS TYROBP causal network in microglia CD84 NRROS FKBP15 LOXL3 PPP1R18 CD37 RNASE6 LGALS9C APBB1IP BIN2 ELF4 NCF2 SFT2D2 TMEM106A RBM47 IGSF6 KCNE3 SAMSN1 NCKAP1L HLX CYTL1 LHFPL2 HIMAP2 GAPT LYL1 TYROBP HEL-S-62p IL10RA C1QC TGFBR1 NPC2 RUNX3 TCIRG1 TNFRSF1B HCLS1 CXCL16 ZFP36L2 SH2B3 PLEK SLC7A7 CREB3L2 DPYD ITGAM IL18 HEL-S-66 ITGAX PYCARD ADAP2 RPS6KA1 SPP1 RGS1 IL13RA1 GPX1 GAL3ST4 MAF VEGFA VEGFR2 SIGNALING%WIKIPATHWAYS_20260510%WP3888%HOMO SAPIENS VEGFA VEGFR2 signaling CREB1 MAP2K3 AMOT PRKAA2 RELA ACACA MAPK9 MAPK8 PLCG1 LDB2 HDAC9 MAPK3 DLL4 CALU ARF6 NAPA MAPK14 ARHA IGFBP7 XB BCL2 CTNNB1 ACTG1 INPP4B tal-1 ACOT9 AP2A1 PFN1 HBD EZR JUN PXN IQGAP1 PIK3CA HEL-S-15 RPS11 HEL-S-102 BRD4 SLC25A11 SDF2L1 TMSB4X TXN HYOU1 HEL-S-87p HEL-S-133P ROCK1 ROCK2 HEL-S-128m HEL-S-68p HEL-S-162eP CDC42 CSK WASF1 LIMK1 SLC2A14 RAP1A FHL2 PSMD4 ADAM10 ELOC ADAM9 FHOD1 HEL-S-2a RAB11A FLT1 RAB5A CCND1 FLII PPP3CA KDR MLST8 HRAS AFDN GPC1 TUBB8 MAP2K2 CCL2 EIF2A TUBA1C SDCBP MMP10 AKT1S1 CLTC NFATC1 ACKR3 EPHA2 NCL SHC1 SRC ITGB3 FOXO1 CACNA2D1 MYL2 ITGAV NFATC2 STAT3 EIF3F FYN MTOR EIF3D EPRS1 PTPN6 MOV10 MDM2 GRB2 VAV2 BIRC5 RPS6KA5 HEL114 PNP OCRL VPS39 RAC1 MMP2 SELE TNFRSF25 SHC2 CTNNA1 PIK3R2 PIK3R1 PAK1 PTPN11 TBCA ARF4 PTMAP7 TMOD1 NOX4 SH3BGRL3 SYNJ1 EPHB2 CYR61 ANXA1 MAPKAPK2 HEL107 SRPK1 GLUD1 EIF4G1 HLX RPL5 TRPC1 TRAF3IP2 RPL7 RPL18A LUC7L UBAP2L CHAC1 SRP54 ATP6V1E1 IER5 TMEM170A SND1 PPP2CA KATNAL2 EWSR1 BIN1 TXNIP RPL27 RPL26 CDC42BPB ATP6V0D1 SH2D2A DKK1 GIGYF2 LMAN1 FXR2 DHX36 SIAH2 BMP2 MICAL2 FBXW11 PRRC2C LARP7 DHX29 PPM1G FARSB NRP2 KCNC3 CCDC124 HDAC1 SHB EEA1 RPLP2 ELOA CLIC1 ATF2 CGNL1 ITGB5 DUSP5 SSR4 MEF2C SSR3 FJX1 KANK1 CNP PTPN1 PRKD2 CRIP2 SLC7A1 SET EGR1 FAF1 APOLD1 FGD5 CCT7 TPM3 HMGB1 TAOK2 COPG1 KL CTNND1 PLOD3 RPL10A CCRL2 DECR1 TMOD3 SEMA6D DPM1 ARMCX1 HDAC7 HGS RAB37 FOXO4 GRB10 MAPKAPK5 ZNF555 NFKBIA DSC1 LRRC59 PSMD11 HTRA1 ZC3H15 MAPK1 HEL-S-94n RAF1 RAB4A HEL-S-84 TNFRSF10C NFKB1 MAP2K6 BMX TFCP2 NR4A3 HEL2 TPP1 GRSF1 CSRP2 C15orf39 BMP10 hEMMPRIN SLC8A1 NRARP CTGF RND1 CAPZB LRRFIP2 GJA1 ADAMTS9 TRPC3 ARHGEF15 PTGS2 SHROOM2 RPL13A PABPC1 HEL164 EPN1 CYP2C8 MMRN2 DNAJB4 FAM120A PRKCB DNAJB9 PRKCE AAG1 ABCF2 PRKCA SLC25A25 PDE4DIP TMSB10 FMNL3 MYO1C PTPN9 FUT1 PRKD1 MAPK12 DOK1 ADRB2 PRKCZ FADD BCL2L1 NCF1 NCF2 TFAM FOXO3A CREBBP MYO6 STAT1 RPS6 CYBB RPS6KB1 ACACB AP2S1 FAS CYCS HDAC5 ARRB2 ENG PLAUR NCK1 TEAD4 MAP2K4 P4HA2 PDPK1 MYH9 PLA2G5 PLCB3 ITCH CRK HBEGF GATA2 CBL FGA EIF3S3 HEL-S-99n FLNB PRKRA HEL-S-78p F3 ITGB1 ALB ERG RAPGEF1 MMP14 PTK2B CAMKK2 ATF4 SPIRE1 NUMB PRKG1 FRS2 PRKAA1 GPX1 MAPKAP1 QK3 RICTOR GSK3B CXCL8 EIF4E VEGFA SARS1 S1PR1 MAP3K5 PRKCI MAP2K1 ERN1 BENZO A PYRENE METABOLISM%WIKIPATHWAYS_20260510%WP696%HOMO SAPIENS Benzo a pyrene metabolism AKR1C4 AKR1C1 HEL-S-165mP EPHX1 CYP3A4 CYP1A1 AKR1C2 CYP1B1 WNT BETA CATENIN SIGNALING IN LEUKEMIA%WIKIPATHWAYS_20260510%WP3658%HOMO SAPIENS Wnt beta catenin signaling in leukemia ZBTB16 CTNNB1 PML AXIN2 BCL9 APC PYGO1 DKK1 RARA TCF3 GSK3B FLT3 JUP LEF1 NR1C2 LRP5 CCND1 LRP6 SALL4 MYC WNT1 RUNX1T1 WIF1 CSNK1A1 NEUROTRANSMITTER DISORDERS%WIKIPATHWAYS_20260510%WP4220%HOMO SAPIENS Neurotransmitter disorders PNMT SLC6A3 TPH2 DDC TH MAOA SLC18A2 DBH TPH1 FAS LIGAND PATHWAY AND STRESS INDUCTION OF HEAT SHOCK PROTEINS%WIKIPATHWAYS_20260510%WP314%HOMO SAPIENS Fas ligand pathway and stress induction of heat shock proteins APAF1 RIPK2 FAF1 CASP8 TNFSF6 PS1TP5BP1 FADD MAPKAPK3 ARHGDIB MAPKAPK2 SMIM40 MAPK8 PRKDC IL1A MAP3K1 LMNA FAS CYCS CASP10 BCL2 TNF ACTG1 PAK1 CASP6 DFFB DFFA MAP2K4 JUN CASP9 MAP3K7 SPTAN1 CASP3 RB1 ACTA1 NFX1 LMNB2 HEL-S-102 PARP1 METHYLATION PATHWAYS%WIKIPATHWAYS_20260510%WP704%HOMO SAPIENS Methylation pathways PNMT MAT1A NNMT TPMT INMT QUERCETIN AND NF KB AP 1 INDUCED APOPTOSIS%WIKIPATHWAYS_20260510%WP2435%HOMO SAPIENS Quercetin and Nf kB AP 1 induced apoptosis JUN VEGFA IKBKB NFKBIA NFE2L2 MAFG CYP2A6 MAFK PTGS2 NFKB1 FOS KEAP1 MAPK CASCADE%WIKIPATHWAYS_20260510%WP422%HOMO SAPIENS MAPK cascade MAP2 MAP2K3 MAPK12 MAPK10 KRAS GRB2 MAP3K2 MAPK3 LAMTOR3 ARAF MAP3K1 RRAS BRAF MAPK1 MAPK14 RAF1 MAP2K6 MBP HRAS MAP2K2 NRAS RASA3 SOS1 SOS2 MAP2K4 JUN PLCB3 SIPA1 MAP2K1 MAP3K12 SUZETRIGINE MECHANISM FOR PAIN RELIEF%WIKIPATHWAYS_20260510%WP5558%HOMO SAPIENS Suzetrigine mechanism for pain relief SCN10A VITAMIN B6 DEPENDENT AND RESPONSIVE DISORDERS%WIKIPATHWAYS_20260510%WP4228%HOMO SAPIENS Vitamin B6 dependent and responsive disorders ALDH7A1 PIGV PLPBP ALPI HEL-S-1a HEL-S-302 ALPL G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20260510%WP45%HOMO SAPIENS G1 to S cell cycle control CREB1 CCNE2 POLA2 CDKN1A CCNB1 ORC6 MNAT1 ORC3 CCND1 ORC2 MYC CDC2 CDK7 CDK2 CDKN1C MCM7 ORC1L TFDP1 TFDP2 MCM3 MCM5 MCM6 MCM2 PCNA RB1 CDC45 CDKN2D CDKN2B CDKN2C WEE1 POLE CDKN2A MDM2 CDK6 CCNG2 PRIM1 ATF6B CDK4 CREB3L3 CREB3L4 CREB3 RPA1 POLE2 MYT1 RPA3 E2F2 E2F3 GADD45A CCND3 CDKN1B CCNE1 ATM CCNH CCND2 PRIM2 HALLMARK OF CANCER NON MUTATIONAL EPIGENETIC REPROGRAMMING%WIKIPATHWAYS_20260510%WP5483%HOMO SAPIENS Hallmark of cancer non mutational epigenetic reprogramming CADM1 TET2 EZH2 CREBBP EP300 NOL9 HDAC2 HDAC1 PIP4K2A IRS1 IFITM3 ANKRD13C EICOSANOID METABOLISM VIA CYCLOOXYGENASES COX %WIKIPATHWAYS_20260510%WP4719%HOMO SAPIENS Eicosanoid metabolism via cyclooxygenases COX PTGDR2 PTGIS PRXL2B PPARG PTGES NR1C2 PLA2G6 PLA2G4B CYP4A11 EHHADH HEL-S-298 PTGDR HPGD PTGS2 PTGFR CYP4F2 CYP4A22 PTGS1 PTGIR PTGR1 PLA2G5 CYP4F12 TBXA2R ACOX3 ACOX1 AKR1B1 OLIGODENDROCYTE DEVELOPMENT%WIKIPATHWAYS_20260510%WP5574%HOMO SAPIENS Oligodendrocyte development MYRF NFATC2 HES5 OLIG2 PTN SOX10 ZNF24 TMEM98 DUSP15 RELN SHH ZNF488 LGI1 NKX2-6 OPALIN OLIG1 ZBTB33 ID4 CNTN1 BMP4 CHD8 SOX6 WNT10A ID2 ASCL1 MBP FGF2 PDGFRA MYT1 NKX6-1 NFIA NKX2-2 EGR2 SOX2 SMAD1 SOX9 SOX8 BMP1 SOX5 TCF7L2 SOX11 PRKCA CSPG4 ZEB2 13Q12 12 COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5406%HOMO SAPIENS 13q12 12 copy number variation MAPK9 MAPK8 DAG1 MIPEP C1QTNF9 TRAF1 ATXN1 SACS TNFRSF19 SNTA1 C1QTNF9B LINGO1 SPATA13 SSPN SNTB1 RAC1 ARHA CDC42 TRAF2 SGCD TRAF5 SGCA TRAF3 RTN4 SGCB SGCG RTN4R DMD CHOLESTEROL BIOSYNTHESIS WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260510%WP4804%HOMO SAPIENS Cholesterol biosynthesis with skeletal dysplasias EBP SC5D DHCR7 DHCR24 CYP51A1 LBR FELBAMATE METABOLISM%WIKIPATHWAYS_20260510%WP2816%HOMO SAPIENS Felbamate metabolism CYP3A4 CYP2E1 OSTEOBLAST DIFFERENTIATION AND RELATED DISEASES%WIKIPATHWAYS_20260510%WP4787%HOMO SAPIENS Osteoblast differentiation and related diseases MAPK9 MAPK8 PRKDC JAG2 DLL3 MAPK3 DLL4 MAPK14 SMAD4 FGF2 CTNNB1 FGF7 FGF8 FGF9 SMAD1 SMAD9 BMP2 DKFZp781O1323 WNT4 PIK3CA BMPR1A BMPR2 GLI3 HEY2 FGF18 IHH FGF10 WNT2B FZD10 WNT5B NOTCH3 PTCH1 WNT9B WNT9A WNT16 PPARG SMO WNT8A WNT8B WNT3 FGF7B WNT10B WNT10A FZD3 FGF7A FZD2 FZD5 FZD4 MAPK1 WNT3A WNT7B FZD7 FZD9 MAPK13 WNT7A FZD8 MAPK6 MAPK4 FGF5C SOX9 PRKCH PRKCB PRKCE PRKCA PIK3R4 PIK3C2G PIK3C2A PIK3C2B PIK3R5 PRKCQ PRKD1 MAPK12 MAPK11 PRKCZ HES6 HES3 PIK3CD MYOD1 STAT1 HES2 LRP5 RBPJ LRP6 WNT1 MAPK10 FZD1 FGFR4 RUNX2 FGFR3 BMP4 FGFR2 FGFR1 MAPK7 PIK3R3 PIK3R2 PIK3R1 NOTCH2 NOTCH1 PRKCI HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES MAPK SIGNALING%WIKIPATHWAYS_20260510%WP4877%HOMO SAPIENS Host pathogen interaction of human coronaviruses MAPK signaling RPS6KA3 MAP2K3 MAPK12 MAPK10 MAPK11 MAP3K11 MAPK9 MAPK8 MAPK3 MAP3K1 IFITM1 MAPK1 MAPK14 IFI27 RAF1 MAP2K6 MAPK13 MAP2K2 BCL2 MAP3K10 RPS6KA2 RPS6KA1 MAP2K4 EIF4E JUN JUNB DDIT3 BST2 ATF2 MAP2K1 IFITM3 FOS IFITM2 SPHINGOLIPID METABOLISM OVERVIEW%WIKIPATHWAYS_20260510%WP4725%HOMO SAPIENS Sphingolipid metabolism overview PLPP2 CERK PLPP1 SGMS1 SPHK1 SGMS2 UGT8 UGCG KDSR GBA2 CERS1 CERS2 SPHK2 SGPP2 SGPP1 SGPL1 SPTLC2 SPTLC1 SMPD1 CERS3 DEGS1 DEGS2 CERS6 PLPP3 HIPK2 IN KIDNEY FIBROSIS%WIKIPATHWAYS_20260510%WP4751%HOMO SAPIENS HIPK2 in kidney fibrosis SIAH1 HIPK2 MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20260510%WP391%HOMO SAPIENS Mitochondrial gene expression POLRMT CREB1 ESRRA HCFC1 PPARGC1B TFB1M TFB2M PPRC1 NRF1 TFAM GABPA MYEF2 CAMK4 MTERF3 PPP3CA GABPB1 MTERF1 PPARGC1A SP1 INFLAMMATORY BOWEL DISEASE SIGNALING%WIKIPATHWAYS_20260510%WP5198%HOMO SAPIENS Inflammatory bowel disease signaling STAT3 TLR4 IL2RG IL13 IL10 IL1A IF2B1 IL23R IL12A RORC TGFB1 RORA STAT1 IL-21 SMAD2 IL2 STAT4 IFNGR1 NFKB1 IL12RB1 IL18 FOXP3 IFNG TNF IL23A IL6 GATA3 HLA-DMA TBX21 IL21R NFATC1 IL4 JUN IL17F IL18RAP TLR5 NOD2 IL5 MAF GROWTH FACTORS AND HORMONES IN BETA CELL PROLIFERATION%WIKIPATHWAYS_20260510%WP5385%HOMO SAPIENS Growth factors and hormones in beta cell proliferation INSR CDK2 PDGFA PDX1 KRAS CRTC2 FLT1 CDK4 MAPK3 IGF1R BRAF FOXO1 MAPK1 RASSF1 MYC AKT3 FOXM1 INS IGF1 RAB43 TGFBR1 ALZHEIMER 39 S DISEASE AND MIRNA EFFECTS%WIKIPATHWAYS_20260510%WP2059%HOMO SAPIENS Alzheimer 39 s disease and miRNA effects CSF1 CSNK1A1L RELA MAPK9 MAPK8 IL1A MAPK3 BRAF PSEN2 AMBRA1 CTNNB1 PLCB4 LPL PIK3CA HEL-S-61 WNT2B FZD10 WNT5B WNT16 SFRP4 APC2 WNT3 WNT10B WNT10A FZD3 FZD2 FZD5 WNT3A WNT7B FZD7 FZD9 WNT7A HEL-S-162eP FZD8 APP PSMD9 PSMD6 PSMD4 PSMD3 GRIN2B PSMD1 GRIN1 ADAM10 VDAC3 NRBF2 ATG2B IDE BACE1 PSMA2 KNS2 ADAM17 PSMA8 PSMB6 PSMB2 PSMB3 PSMC1 HEL-S-276 RTN3 GPR83 KLC4 KLC3 KLC2 NAE1 ATP2A1 SLC25A6 BECN2 ADRM1 SLC25A31 PIK3CD ULK1 AKT3 PPP3CA HRAS TUBAL3 ATG101 TUBB8 TUBA3E MAP2K2 TUBA1C TUBB6 TUBA1B TUBA1A AXIN2 TUBB1 TUBB TUBB4B TUBB4A ULK2 TUBA4A FRAT1 TUBB2A DVL1 DVL2 DVL3 TUBA2 RB1CC1 AXIN1 LRP5 TUBA8 CSNK1E PSEN1 LRP6 WNT1 EIF2AK2 CSNK1A1 INSR MTOR CSNK2A1 APC NOS2 KRAS EIF2S1 CDK5 PSENEN IL1B CALML6 ARAF KIF5A CALML3 CALML4 SNCA CDK5R1 DKK4 APOE PIK3R3 PPIF PIK3R2 PIK3R1 NRAS RTN4 BAD NOX4 CHRNA7 WIPI1 WIPI2 ATG14 DKK1 ATG2A PSMD2 SHFM1 WNT4 IRS4 PSMD7 PSMD12 PSMD13 IKBKB FRAT2 CHUK MAPK1 RAF1 NFKB1 TRAF2 PTGS2 IRS1 TNFRSF1A PIK3R4 XBP1 INS APAF1 ITPR2 CACNA1C CASP8 CSNK2A3 FADD CSNK2A2 HSD17B10 DKK2 CACNA1S PLCB1 HEL-S-91n CSNK2B PPP3R2 CYBB FAS AGER CYCS PSMC6 PSMC4 CALM1 CACNA1F ATP2A2 RYR3 MME APH1B PLCB3 DDIT3 SLC25A5 MAPK10 FZD1 PPP3CC SLC25A4 PLCB2 ATF4 PPP3R1 TNF IL6 GSK3B MCU CASP9 PSMA4 CASP12 CASP3 MAP3K5 MAP2K1 ERN1 NAD METABOLISM SIRTUINS AND AGING%WIKIPATHWAYS_20260510%WP3630%HOMO SAPIENS NAD metabolism sirtuins and aging ROS1 SIRT1 HIF1A FOXO1 SIRT3 NAMPT PARP1 NFKB1 TFAM PPARG FOXO3A 3Q29 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP4906%HOMO SAPIENS 3q29 copy number variation syndrome DYNLL2 NRROS DNCL1 STAT5B TGFB1 RNF168 MYC RNF8 TFRC UBXN7 SMCO1 MFI2 MYCBP2 NCBP1 FBXO45 TF NCBP2 ZDHHC19 BRINP1 TM4SF19 HIF1A CEP350 PIGX FBXW7 MCRS1 MAD2L1BP WDR53 ZNF76 PIGM SLC51A PXN JUN SLC51B DYNC2I2 SLC40A1 CEP19 HFE HEL-S-71 H2BC21 DYNC2H1 DYNLT1 FNDC8 PIK3R3 SIRT1 DYNLT2B DYNLRB2 DYNC2LI1 NF2 ADAM10 RABL2B DYNLT3 HAMP CYTOPLASMIC RIBOSOMAL PROTEINS%WIKIPATHWAYS_20260510%WP477%HOMO SAPIENS Cytoplasmic ribosomal proteins RPS6KA3 RPS6 RPS6KB1 RPL5 RPS6KB2 RPL7 RPL18A RPL27 RPL26 RPS15 HEL-S-310 RPS14 RPL4 RPL11 RPL3 RPS17 RPL32 RPS16 RPL31 RPS19 RPLP1 RPS18 RPL34 RPLP0 RPL8 RPS11 RPL9 RPS10 RPL6 RPS13 RPS4X RPL7A RPLP2 RPS9 RPL36 RPL35 RPS7 RPL38 RPS8 RPL37 RPS5 RPL39 RPL21 RPSA RPL22 RPS3A RPL37A RPL29 RPL28 RPL10 RPL12 MRPL19 RPL36A RPS4Y1 RPL14 RPL10A RPL13 RPL15 RPL18 RPL17 RPS26 RPL19 RPS28 RPL41 RPS29 RPL35A RPL23A RPS20 RPL3L RPS25 RPS21 RPS27 RPS24 RPL27A RPS23 RPL23 RPL30 RPS15A RPS3 RPS6KA6 RPS2 RPS6KA2 RPS6KA1 RPS27A RPL13A FAU FOCAL ADHESION%WIKIPATHWAYS_20260510%WP306%HOMO SAPIENS Focal adhesion RASGRF1 MAPK9 MAPK8 MYLK3 TNK2 MAPK3 BRAF ARHA ARHGAP35 TLN1 MYLK BCL2 XB ACTG1 CTNNB1 VWF ACTN1 PXN JUN PIK3CA TNC PIP5K1C VEGFC LAMC1 ITGB5 IGF1 FLNA PPP1CC ITGB8 ITGA7 ITGA2B PS1TP5BP1 RAC3 ITGA1 VAV1 MAPK1 DOCK1 RAF1 ROCK1 c-fgr ROCK2 VEGFB CDC42 VEGFD IBSP SPP1 MYL12B COL4A1 COL4A4 COL4A6 RAP1A COL1A1 PRKCB COL2A1 PRKCA LAMC2 LAMA1 ERBB2 LAMA4 LAMA3 MYL11 LAMB3 LAMB2 LAMB1 RELN VTN HEL-S-80p FLT1 ITGA4 PTEN HEL-S-28 PIK3CD VAV3 IGF1R THBS2 CCND1 AKT3 KDR HRAS PDGFRA ITGB6 CRKL COL1A2 ACTN4 SOS1 MET PDPK1 PARVA SHC1 SRC CAV3 CAV2 ITGB3 CRK EGFR SHC4 ITGA6 SHC3 MYL2 ITGAV PAK6 FLNB PAK4 EGF MAPK10 ITGB1 FYN PDGFD LAMA5 HGF PDGFC PDGFA GRB2 VAV2 COL4A2 RAPGEF1 BIRC3 HEL114 MYLK4 COMP TNR MYL5 THBS1 MYL7 RAC1 TLN2 BLK ITGA2 TXK ITGB7 MYLK2 MYL12A CHAD SHC2 MYL10 PIK3R3 SRMS PIK3R2 TNK1 PIK3R1 PTK6 PARVB VASP PARVG PAK1 COL5A3 COL5A2 ARHGAP5 BIRC2 ZYX EMP2 PPP1R12B PPP1R12C BAD THBS4 THBS3 STYK1 GSK3B VEGFA ITGB4 CCND3 MAP2K1 CCND2 OLIGODENDROCYTE SPECIFICATION AND DIFFERENTIATION LEADING TO MYELIN COMPONENTS FOR CNS%WIKIPATHWAYS_20260510%WP4304%HOMO SAPIENS Oligodendrocyte specification and differentiation leading to myelin components for CNS CNP OLIG2 SOX10 SHH NKX2-6 OLIG1 BMP4 MOG IL1B SOX6 CXCL1 ASCL1 CXCL2 MBP FGF2 MYT1 TNF NKX2-2 SOX9 OMG SOX8 BMP2 SOX5 LIF CNTF IGF1 OSX AND MIRNAS IN TOOTH DEVELOPMENT%WIKIPATHWAYS_20260510%WP3971%HOMO SAPIENS OSX and miRNAs in tooth development CTNNB1 NOTCH2 NOTCH3 DKK1 NOTCH1 DMP1 HNF1A RUNX2 DSPP ALPL KLF4 SP7 SOST BMP7 4P16 3 COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5365%HOMO SAPIENS 4p16 3 copy number variation NELFB NELFCD H3F3B GRB2 PLCG1 FGFR3 MAPK3 ERI1 MAPK1 FGF2 PIK3R1 FRS2 SOS1 POLN SLBP CLTCL1 NSD2 NELFA UBE2J2 FAM53A CKAP5 LETM1 NICOL1 TACC3 CBL NAT8L LIPID METABOLISM PATHWAY%WIKIPATHWAYS_20260510%WP3965%HOMO SAPIENS Lipid metabolism pathway PRKAA2 LIPE PRKACG PRKAG1 PRKAG2 ACACA PRKAA1 PRKAG3 PLIN1 ABHD5 ACSS2 PNPLA2 PRKAB2 HILPDA FASN PRKAB1 PDHA1 PRKAR1B AKT3 PRKAR1A ACLY MIRNA REGULATION OF DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260510%WP1530%HOMO SAPIENS miRNA regulation of DNA damage response CREB1 CHEK1 MRE11A NBN APAF1 BBC3 CASP8 CCNE2 RFC1 SFN RAD9A CDKN1A PRKDC CCNB3 CCNB2 CCNB1 CCND1 MYC FAS CYCS CDC2 CDK2 FANCD2 ATR TLK1 TNFRSF10B TP53AIP1 SMC1A ATRIP RAD17 RAD1 RB1 PML HUS1B BRCA1 PIDD1 MDM2 CCNG1 TLK2 CDK5 CDK6 CDK4 RRM2B DDB2 SESN1 GADD45B PMAIP1 GADD45A GADD45G BAX H2AX CASP9 RAD52 CCND3 CDKN1B CCNE1 CASP3 ATM CCND2 RAD50 CHEK2 RAD51 INTERACTIONS BETWEEN IMMUNE CELLS AND MICRORNAS IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260510%WP4559%HOMO SAPIENS Interactions between immune cells and microRNAs in tumor microenvironment CCL2 STAT3 TGFBR2 CTLA4 TLR4 TLR7 IL2RG PDCD1 IL2RB IL4 IL2RA TGFB1 NFKB2 TLR8 CD80 TRAF6 IRAK4 NFKB1 SOCS1 CCL5 VITAMIN D SENSITIVE CALCIUM SIGNALING IN DEPRESSION%WIKIPATHWAYS_20260510%WP4698%HOMO SAPIENS Vitamin D sensitive calcium signaling in depression TPH2 ITPR2 CACNA1C CYP27B1 ATP2B3 ATP2B2 ATP2B1 NR1i1 CHRM1 BCL2 SLC8A1 RXRA KDM6B KCNQ2 KCNQ3 KDM3A CYP27A1 NFE2L2 KDM1A GRIN2B HEL-75 KDM1B GRIN1 GCLC CALB1 ATP2B4 PVALB TPH1 APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20260510%WP384%HOMO SAPIENS Apoptosis modulation by HSP70 APAF1 MAPK10 CASP8 CASP6 TNFSF6 CASP2 FADD RIPK1 CASP9 MAP3K1 AIFM1 CASP3 TNFRSF1A FAS NFKB1 CYCS METABOLIC PATHWAYS OF FIBROBLASTS%WIKIPATHWAYS_20260510%WP5312%HOMO SAPIENS Metabolic pathways of fibroblasts PLOD1 ALDH18A1 ADAMTS2 GCK GLS PSAT1 PHGDH PSPH BMP1 FGFR4 P4HA1 PLCG1 LOXL2 P4HA2 LPAR1 FGFR1 GLUD1 UGDH HEL-S-133P P3H4 P3H3 ARHA P4HA3 CD36 THYROID HORMONES PRODUCTION AND PERIPHERAL DOWNSTREAM SIGNALING EFFECTS%WIKIPATHWAYS_20260510%WP4746%HOMO SAPIENS Thyroid hormones production and peripheral downstream signaling effects TTF2 AQP7 TTF1 NHSL1 DUOXA2 SECISBP2L ITPR2 DUOX2 DEHAL1 TG SLC26A4 SLCO1C1 MAPKAPK3 SLC16A10 SLC16A2 RPS6 TPO RPTOR RPS6KB1 MAPK14 AKT3 POMC MLST8 HRAS CTNNB1 TSC2 TSC1 RXRA AKT1S1 SOS1 MAFA PIK3CA WNT4 ADRB3 SRC ITGB3 FOXO1 FGF21 ATF2 ITGAV ADCY3 PAX8 ADCY8 THRA MTOR ACTL6B RHEB SHH MDM2 GRB2 PPARG FGFR1 PFKFB2 CREB3 MAPK1 RAF1 SLC5A5 SIRT6 PRDM16 TBC1D4 RPS6KA6 TSHB FRS2 ZNF516 NOTCH1 BAD PLIN1 MGLL TSHR GSK3B KDM3B MC4R UCP1 DIO1 NPY CASP9 AgRP PNPLA2 KDM1A NR1A2 NPPB MAP2K1 PPARGC1A TRH PROSTAGLANDIN AND LEUKOTRIENE METABOLISM IN SENESCENCE %WIKIPATHWAYS_20260510%WP5122%HOMO SAPIENS Prostaglandin and leukotriene metabolism in senescence GNAI1 MAPK11 PTGIS PRXL2B KRAS CDKN1A ALOX5AP PTGES ALOX12 IGFBP5 GNAS HRAS NRAS ALOX15 SIRT1 PTGER4 PTGS2 PTGS1 PTGER1 PTGER2 LTC4S PTGER3 ALOX15B ALOX5 RB1 ADCY3 SRF AND MIRS IN SMOOTH MUSCLE DIFFERENTIATION AND PROLIFERATION%WIKIPATHWAYS_20260510%WP1991%HOMO SAPIENS SRF and miRs in smooth muscle differentiation and proliferation MEF2D KLF4 CAMK2D MYOCD NKX2-5 CCND2 MEF2C MEF2B FAMILIAL HYPERLIPIDEMIA TYPE 2%WIKIPATHWAYS_20260510%WP5109%HOMO SAPIENS Familial hyperlipidemia type 2 EPHX2 APOB GHR LIPC LPL PCSK9 APOA4 PLTP APOA2 LDLR USF1 GPIHBP1 CAFFEINE AND THEOBROMINE METABOLISM%WIKIPATHWAYS_20260510%WP3633%HOMO SAPIENS Caffeine and theobromine metabolism CYP1A2 XDH CYP2A6 NAT2 BLOOD BASED NEUROINFLAMMATION MARKERS %WIKIPATHWAYS_20260510%WP5548%HOMO SAPIENS Blood based neuroinflammation markers PBR CCL2 BDNF TNF IL6 GRN CCL11 CCL23 ADM NEFL TREM2 OLR1 CRP TREM1 IL1B S100B GFAP CHI3L1 CX3CL1 CCL5 DBI TRANSCRIPTIONAL CASCADE REGULATING ADIPOGENESIS%WIKIPATHWAYS_20260510%WP4211%HOMO SAPIENS Transcriptional cascade regulating adipogenesis CEBPD CEBPB EGR2 GATA3 DDIT3 KLF15 CEBPG KLF2 KLF5 GATA2 PPARG CEBPA ALSTROM SYNDROME%WIKIPATHWAYS_20260510%WP5202%HOMO SAPIENS Alstrom syndrome IFT27 PTCH1 IFT25 SMO VCP BLOC1S4 VCPIP1 BLOC1S6 GPR161 BLOC1S1 CIMAP3 SNAPIN RFX2 DTNBP1 RFX3 RFX1 IFT81 TUBG1 RILPL1 MYO5B ALMS1 STX5A IFT74 ACTN4 TFDP2 CEP192 CEP19 IFT172 E2F4 RABL2B DNM3 LIDOCAINE METABOLISM%WIKIPATHWAYS_20260510%WP2646%HOMO SAPIENS Lidocaine metabolism CYP1A2 CYP3A4 FERROPTOSIS%WIKIPATHWAYS_20260510%WP4313%HOMO SAPIENS Ferroptosis SLC3A2 MAP1LC3C SLC7A11 HMOX1 AKR1C2 CYBB DKFZp762B153 MAP1LC3A TFRC ATG5 SAT2 POR CHMP6 CHMP5 TF DPP4 FTMT CP PCBP1 LPCAT3 FTL ACSL1 FACL4 IREB2 SLC40A1 ACSL3 BACH1 HEL-S-102 COQ2 CBS FTH1 SLC39A8 AKR1C1 CISD1 ACSL6 ACSL5 GPX4 ALOX15 STEAP3 SLC38A1 HEL-S-64p SLC39A14 HMGCR PHKG2 PRNP SLC11A2 GCLC AIFM2 VDAC3 CTH GCLM FDFT1 NOX4 KREBS CYCLE DISORDERS%WIKIPATHWAYS_20260510%WP4236%HOMO SAPIENS Krebs cycle disorders LDHB SUCLG2 PDHX PCK2 FH SUCLA2 DHTKD1 MPC1 HEL-S-133P SUCLG1 GPT VALPROIC ACID PATHWAY%WIKIPATHWAYS_20260510%WP3871%HOMO SAPIENS Valproic acid pathway HDAC1 HADHB EHHADH CYP2A6 CYP2B6 HSD17B10 IVD ACADSB CYP2C9 ABAT INTEGRATED BREAST CANCER PATHWAY%WIKIPATHWAYS_20260510%WP1984%HOMO SAPIENS Integrated breast cancer pathway CREB1 CHEK1 MRE11A EP300 BRCA2 CDC25B ANXA1 GRN DAG1 APOBEC3G BRAF BLM SMAD2 SMAD4 FOSL2 PLK1 HIPK2 FOSL1 CDK7 SP1 CDK2 BCL2 ATR CTNNB1 SMAD1 TFPI ERAL1 SMEK1 ZMYND8 NAB1 MAP3K7CL JUN ALKBH1 RPP38 RALGAPA1 PPP4R3B BMPR1A CCNB1IP1 HDAC1 LGALS13 BMPR2 RB1 NUP85 PLK3 XRCC3 FER MAP3K7IP1 MAP3K13 PIGR RASGEF1A DCAKD ITPKC USP15 WEE1 USP16 AURKA USP21 FILIP1 MAX TPR MSH6 SMARCA4 CDK4 CHUK RRAS BARD1 TRADD MAPK1 NFKB1 CDC42 CERK ZNF655 SIRT1 RAP1A FAU RASGRP3 IRS1 ZMIZ1 UBE2F PIAS1 RALA CASP8 FADD GSK3A GDI1 JAK1 PTEN STAT1 AHR PKIA CCND1 MYC TGFBR1 MYCBP2 TSC2 TSC1 SMAD6 BACH1 CSNK1D EGFR FOXO1 DHTKD1 PML MTOR MSH2 RHEB BRCA1 MDM2 KRAS NOXA1 ATF1 EDAR RHO ARAF RAC1 STK11 MYT1 PIK3R2 TGFBR2 SELENOK PAK1 BAK1 BAD GADD45A NF1 BAX VEGFA CASP9 HMGCR ATM CASP3 RAD50 CHEK2 RAD51 MITOCHONDRIAL COMPLEX III ASSEMBLY%WIKIPATHWAYS_20260510%WP4921%HOMO SAPIENS Mitochondrial complex III assembly UQCRB UQCC3 UQCC2 UQCR11 UQCR10 TTC19 CYB UQCRH UQCRQ LYRM7 UQCRC1 UQCRFS1 CYC1 UQCRC2 UQCC SOX GENES AND THEIR INFLUENCE ON NEUROGENESIS AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260510%WP5568%HOMO SAPIENS SOX genes and their influence on neurogenesis and neurodevelopmental disorders WWTR1 SOX4 YES1 SOX2 POU3F2 TEAD2 SRRT SOX11 SOX12 POU3F1 UTF1 FGF7A SOX15 ZSCAN10 H4C9 HIST1H4L INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20260510%WP453%HOMO SAPIENS Inflammatory response pathway ZAP70 LAMB2 LAMA5 IL2RG LAMB1 VTN IL5RA CD40LG THBS1 IL2 IFNG LCK IL2RB COL1A2 THBS3 CD40 IL4 TNFRSF1B COL1A1 COL3A1 IL2RA CD80 LAMC2 TNFRSF1A LAMC1 IL5 PROXIMAL TUBULE TRANSPORT%WIKIPATHWAYS_20260510%WP4917%HOMO SAPIENS Proximal tubule transport SLC2A2 SLC3A2 SLC9A3 SLC5A1 HEL-76 CA4 SLC22A2 ATP6V1C1 SLC34A3 SLC4A4 ATP6V1G1 SLC6A19 SLC34A1 SLC6A18 SLC16A10 SLC7A7 SLC36A2 SLC5A8 CLTRN SLC7A9 SLC3A1 SLC47A2 SLC5A2 ATP6V1A SLC6A20 SLC22A6 SLC47A1 FXYD2 SLC5A5 ATP6V0A4 ATP6V0E1 ATP6V0D2 ATP6V1D SLC22A11 ATP6V1E1 ATP6V0B ATP6V0C SLC22A7 ATP6V1B1 AQP1 ABCC2 ABCB1 ATP6V1F ATP1B1 ABCG2 SLC1A1 ATP1A1 MITOCHONDRIAL FATTY ACID SYNTHESIS PATHWAY%WIKIPATHWAYS_20260510%WP4317%HOMO SAPIENS Mitochondrial fatty acid synthesis pathway OXSM HTD2 MCAT MECR ACACA HSD17B12 OREXIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260510%WP5094%HOMO SAPIENS Orexin receptor pathway CREB1 PRKD1 LHB EIF4B PRKCZ IL9 GNRH1 MAPK9 MAPK8 IL10 MAPK3 DAGLA RPS6 RPS6KB1 CCK MAPK14 POMC GNAS STAR MAP2K2 TH ARRB2 HIF1A SMAD1 DKFZp781O1323 IL4 PDPK1 BMPR1A FOXO1 EIF4EBP1 GNAI1 GCG STAT3 MTOR GNA11 DYNLT1 RUNX2 IL1B MAPK7 MAPK1 CXCL2 CAMKK2 BMP7 LEP GH1 SLC2A4 TNF PIK3R2 PIK3R1 NPFFR1 IL6 FSHB BGLAP RPS6KA1 SGK1 NPVF HCRT PRKAA1 VHL OPRK1 CGA PTPN11 HCRTR2 CXCL8 HCRTR1 NPY CASP9 PRKCB PRKCE PRKCA NFE2L2 CASP3 GHRL SLC1A2 MAP2K1 DYNLT3 NOX4 G13 SIGNALING%WIKIPATHWAYS_20260510%WP524%HOMO SAPIENS G13 signaling MAPK10 WASL ARHGDIG ARHGDIB PKN1 HEL-S-80p TNK2 CIT PIK3CD RPS6KB1 ARHGEF1 ROCK1 RAC1 ROCK2 WAS ARHA SH3RF1 GNA13 CDC42 CALM1 PIK3R2 CFL2 LIMK1 PIP4K2A RTKN RHPN2 MYL1 MYBPH PFN1 IQGAP1 PIK3CA HEL-S-15 CYFIP1 AMYOTROPHIC LATERAL SCLEROSIS ALS %WIKIPATHWAYS_20260510%WP2447%HOMO SAPIENS Amyotrophic lateral sclerosis ALS APAF1 BCL2L1 SMIM40 RAB5A PPP3CC MAPK14 RAC1 PPP3CA MAP2K6 MAP2K2 BCL2 TNF HEL-S-2 HEL-S-44 NEF3 GPX1 BAD TOMM40 NEFL DERL1 BAX CASP9 CASP12 CASP3 MAP3K5 TNFRSF1A SLC1A2 NEFH CCS MAPK PATHWAY IN CONGENITAL THYROID CANCER%WIKIPATHWAYS_20260510%WP4928%HOMO SAPIENS MAPK pathway in congenital thyroid cancer MAP2K2 KSR1 GAREM2 KRAS SOS1 SOS2 JUN MAPK3 SHC1 ALK BRAF MYC RAF1 MAP2K1 FOS EGF EGFR SIGNALING%WIKIPATHWAYS_20260510%WP437%HOMO SAPIENS EGF EGFR signaling SYNJ1 CREB1 MAP2K5 PTPN5 MAPK9 MAPK8 PLCG1 TNK2 JUND ARF6 BRAF MAPK14 STXBP1 PLCE1 SP1 FOSB SH2D2A AP2A1 JUN IQGAP1 HEL-S-15 SH3GL2 PCNA CBLC MEF2C HGS MEF2D FOXO4 GRB10 VAV1 MAP3K1 ARHGEF1 MAPK1 RAF1 ROCK1 CDC42 CSK MAPK4 GJA1 RALBP1 PLSCR1 EPN1 USP6NL RAP1A NDUFA13 INPPL1 PRKCB PLD2 STAMBP PRKCA STAM2 HEL-S-34 EPS15L1 ASAP1 REPS2 PIK3C2B RALA RALB ERBB2 RPS6KA3 INPP5D GAB2 PRKCZ LIMK2 JAK1 STAT5B RAB5A PTEN VAV3 STAT1 RPS6KB1 RIN1 AP2S1 AP2M1 NEDD8 HRAS MAP2K2 CRKL NCK2 SOS1 NCK1 SOS2 PDPK1 SHC1 SRC ITCH CAV2 CRK EGFR FOXO1 CAMK2A CBL EIF4EBP1 ATXN2 EGF STAT3 MTOR KRAS GRB2 VAV2 MAP3K2 MAP4K1 ATF1 MAPK7 RPS6KA5 PTK2B SPRY2 RAC1 PXDN PIK3R2 PIK3R1 PTK6 PAK1 NEDD4 RPS6KA2 RPS6KA1 SH3GL3 COX2 PTPN11 RICTOR ERRFI1 PRKCI MAP2K1 FOS INTERFERON SIGNALING IN TUBERCULOSIS%WIKIPATHWAYS_20260510%WP4197%HOMO SAPIENS Interferon signaling in tuberculosis IRF9 IFNAR2 IFNG IFNAR1 STAT2 MX1 TAP1 JAK1 STAT1 IFIT1 IRF1 IFITM1 IFNGR2 IFI35 PSMB8 IFIT3 IFNGR1 SOCS1 OAS1 TYK2 PIAS1 CODEINE AND MORPHINE METABOLISM%WIKIPATHWAYS_20260510%WP1604%HOMO SAPIENS Codeine and morphine metabolism UGT2B7 UGT1A10 UGT1A8 ABCC3 ABCC2 UGT1A9 ABCB1 CYP3A4 CYP2C8 UGT1A3 SLCO1B1 UGT1A1 UGT2B4 DISRUPTION OF POSTSYNAPTIC SIGNALING BY CNV%WIKIPATHWAYS_20260510%WP4875%HOMO SAPIENS Disruption of postsynaptic signaling by CNV DLG2 SHANK1 NLGN1 ARC FMR1 CAMK2G MAPK3 NRXN1 NRXN3 MAPK1 NRXN2 STX1A RPH3A RYR2 YWHAG SYNGAP1 DLGAP1 HOMER1 CAMK2D GRIN2B GRIN1 CAMK2A TJP1 NLGN3 NLGN2 CYFIP1 DENGUE 2 INTERACTIONS WITH COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260510%WP3896%HOMO SAPIENS Dengue 2 interactions with complement and coagulation cascades C1R CFI C5AR1 C4B_2 C2 C6 PLAT C7 C9 CD55 HEL-S-62p APOA2 C1QC THBD VWF SERPINF2 F5 F8 CPB2 SERPINC1 TFPI LMAN1 CLTC F2R SERPIND1 PLAUR KLKB1 F7 PLG F3 HEL-S-78p KNG1 BDKRB1 F13B F2 PROS1 CLU C8G SERPINA1 C3AR1 F9 PROC CR2 F10 CR1 SERPING1 MASP2 C1QA MASP1 CD46 CFD C1QB C1S CFH KININ KALLIKREIN PATHWAY%WIKIPATHWAYS_20260510%WP5089%HOMO SAPIENS Kinin Kallikrein pathway SERPING1 CPN1 KLKB1 KNG1 BDKRB2 BDKRB1 INVOLVEMENT OF SECRETASE IN NEURODEGENERATIVE DISEASES%WIKIPATHWAYS_20260510%WP5372%HOMO SAPIENS Involvement of secretase in neurodegenerative diseases SRPK2 BDNF CEBPB SET STAT1 SNCA AKT3 APP BACE1 NTRK2 TARDBP POST COVID NEUROINFLAMMATION%WIKIPATHWAYS_20260510%WP5485%HOMO SAPIENS Post COVID neuroinflammation IFNG TNF ACE2 TLR4 HMGB1 IL6 TLR7 TLR3 CCL11 IL10 IL1A IL4 CXCL8 FURIN IL12A IL1B TLR8 GFAP MAPK1 IL2 TMPRSS2 IL18 IFNA2 GENES AND COMPLEXES INVOLVED IN THE DNA REPAIR PATHWAYS%WIKIPATHWAYS_20260510%WP4946%HOMO SAPIENS Genes and complexes involved in the DNA repair pathways POLD2 CHEK1 MRE11A NBN BRCA2 RAD54B PARP2 MGMT RBX1 POLE4 PRKDC TDG POLE3 FEN1 FAN1 CDK7 FANCD2 ATR BRIP1 FANCM FANCL FANCA USP1 FANCC MPG OGG1 PNKP XRCC5 UNG NTHL1 PALB2 POLL MUTYH MBD4 PCNA SMUG1 NEIL3 NEIL2 HMGB1 MSH3 NHEJ1 POLE RFC3 RFC4 MSH6 POLD3 WRN RPA1 FANCG POLE2 RPA3 APEX1 RAP1A REV1 FANCB FANCE FANCF REV3L POLI RAD51C CETN2 FAAP24 XPA PMS2 XPC CENPX GTF2H2C_2 POLM LIG1 APEX2 RFC1 CENPS RFC2 GTF2H2 GTF2H3 GTF2H5 CUL4A DDB1 ERCC1 ERCC2 ERCC5 MNAT1 CUL4B MSH2 BRCA1 POLK WDR48 DDB2 TERF2 H2AX RAD52 ATM CCNH PARP1 POLD4 RAD50 RAD51 GASTRIC CANCER NETWORK 2%WIKIPATHWAYS_20260510%WP2363%HOMO SAPIENS Gastric cancer network 2 TOP2A RFC3 RFC4 AHCTF1 DSCC1 S100A6 CHTF18 MTDH CHTF8 BRIX1 UBE2C ATAD2 CACYBP FAM91A1 RNF144B DGIC UBE2T COL9A1 SNURF MYC CD48 COL9A3 CEBPZ LBR CTNNB1 OTUD5 RAD17 EGFR LMNB2 ESTROGEN RECEPTOR PATHWAY%WIKIPATHWAYS_20260510%WP2881%HOMO SAPIENS Estrogen receptor pathway JUN CYP1A2 STAT3 GPAM PCK1 ACOX1 NR0B2 CYP1A1 PDK4 CYP1B1 NR1C1 SP1 FIBROTIC RESPONSE OF TRABECULAR MESHWORK CELLS TO TGFB3 AND ENPP2 IN AQUEOUS HUMOR%WIKIPATHWAYS_20260510%WP5545%HOMO SAPIENS Fibrotic response of trabecular meshwork cells to TGFB3 and ENPP2 in aqueous humor COL1A1 TGFB1 STAT3 RHO MAPK10 CTGF MAPK9 LPA ACTA2 MAPK8 ENPP2 ARTEMISININ INHIBITION OF UVEAL MELANOMA%WIKIPATHWAYS_20260510%WP5441%HOMO SAPIENS Artemisinin inhibition of uveal melanoma MTOR AKT3 INTERLEUKIN 1 IL 1 STRUCTURAL PATHWAY%WIKIPATHWAYS_20260510%WP2637%HOMO SAPIENS Interleukin 1 IL 1 structural pathway MAP2K3 MAPK10 NFKBIB IRF7 MAPK11 RELA MAPKAPK2 MAPK9 MAPK8 IL1R1 IL1A MAP3K8 TAB3 MAPK3 IKBKB NFKBIA RPS6KA5 MAP3K1 CHUK TRAF6 MAPK1 MAPK14 IRAK4 MYC MAP3K14 NFKB1 MAP2K6 MBP SAFB MAP2K2 TANK MYD88 MAP2K4 EIF4E MAP3K7 IRAK2 MAP3K7IP1 ATF2 MAP2K1 IRAK1 FOS ENTEROHEPATIC CIRCULATION OF BILE ACIDS%WIKIPATHWAYS_20260510%WP5396%HOMO SAPIENS Enterohepatic circulation of bile acids SLC51B ABCB11 SLCO1B1 ABCC3 FABP6 ABCC2 ABCB1 SLC10A2 SLC51A OVERLAP BETWEEN SIGNAL TRANSDUCTION PATHWAYS CONTRIBUTING TO LMNA LAMINOPATHIES%WIKIPATHWAYS_20260510%WP4879%HOMO SAPIENS Overlap between signal transduction pathways contributing to LMNA laminopathies CTSK HES5 TCF7L1 CSNK1A1L APC GDF8 PS1TP5BP1 PPARG CDKN1A RUNX2 HES1 CDK4 CREBBP TGFB1 WNT10B MYOD1 LMNA SMAD2 WNT7B ZMPSTE24 CEBPA TNFRSF11B CEBPD LEMD3 CTNNB1 CEBPB MAOA SPP1 NOTCH1 BMP2 GSK3B FNTA EMD TCF7L2 ICMT LEF1 HMGA2 HDAC1 AXIN1 DICER1 AGO2 TARBP2 RB1 JUNB CSNK1A1 KAT2B METASTATIC BRAIN TUMOR%WIKIPATHWAYS_20260510%WP2249%HOMO SAPIENS Metastatic brain tumor CDC42 PIK3R1 E2F3 MYC CDK6 BMP SIGNALING IN EYELID DEVELOPMENT%WIKIPATHWAYS_20260510%WP3927%HOMO SAPIENS BMP signaling in eyelid development INHBB PITX2 FGF10 SMAD1 SHH NOTCH1 MAPK9 DKK2 SFRP1 DKFZp781O1323 JUN BMP4 FGFR2 MAPK3 MAP3K1 FOXC2 FOXC1 EGFR SMAD4 TGFA CATABOLISM OF SKELETAL MUSCLE IN CACHEXIA%WIKIPATHWAYS_20260510%WP5474%HOMO SAPIENS Catabolism of skeletal muscle in cachexia EP300 STAT3 MTOR MAPK11 RELA TRIM63 FBXO32 GDF8 REL IL1R1 IL1A FOXO3A JAK1 IKBKB IL1B NFKBIA IGF1R CHUK RPTOR IKBKG SMAD2 SMAD4 NFKB1 MAP1LC3A MLST8 IL6R TNF CEBPB TWEAK RELB TNFRSF12A ACVR2A IL6 AKT1S1 NFKB2 TNFRSF1A IGF1 FOXA2 PATHWAY%WIKIPATHWAYS_20260510%WP5066%HOMO SAPIENS FOXA2 pathway PPARGC1B FOXA1 ABCC3 ABCC2 ACACA MTTP FOXA2 GSTM2 SLCO1B1 APOB FASN IRS1 FOXO1 SLC27A5 MLXIPL INS LEUCINE ISOLEUCINE AND VALINE METABOLISM%WIKIPATHWAYS_20260510%WP4686%HOMO SAPIENS Leucine isoleucine and valine metabolism ACAD8 ACSF3 DBT PCCA MLYCD HSD17B10 BCAT1 IVD BCAT2 ACADSB PCCB ECHS1 MCCC2 DLD MCCC1 ACAT1 FGFR4 P G388R SIGNALING%WIKIPATHWAYS_20260510%WP5428%HOMO SAPIENS FGFR4 p G388R signaling STAT3 FGFR4 IL10 WNT SIGNALING IN ADULT HIPPOCAMPAL NEUROGENESIS%WIKIPATHWAYS_20260510%WP5536%HOMO SAPIENS Wnt signaling in adult hippocampal neurogenesis WNT3 FZD3 CCND1 WNT3A LRP6 FZD1 NEUROG2 PROX1 NEUROD1 WNT7A LAMIN A PROCESSING PATHWAY%WIKIPATHWAYS_20260510%WP4299%HOMO SAPIENS Lamin A processing pathway ICMT LMNA ZMPSTE24 MULTIPLE EPIPHYSEAL DYSPLASIA AND PSEUDOACHONDROPLASIA GENES%WIKIPATHWAYS_20260510%WP4789%HOMO SAPIENS Multiple epiphyseal dysplasia and pseudoachondroplasia genes COMP COL9A1 COL9A3 MATN1 COL9A2 MATN3 NANOPARTICLE TRIGGERED REGULATED NECROSIS%WIKIPATHWAYS_20260510%WP2513%HOMO SAPIENS Nanoparticle triggered regulated necrosis TICAM1 TNF CASP8 TRADD TNFRSF1A FADD RIPK1 FTL MAPK8 PARP1 RIPK3 LNCRNA MEDIATED MECHANISMS OF THERAPEUTIC RESISTANCE%WIKIPATHWAYS_20260510%WP3672%HOMO SAPIENS lncRNA mediated mechanisms of therapeutic resistance HIF1A ABCB1 BCL2L1 CDKN1A SEBALEIC ACID FORMATION AND METABOLISM%WIKIPATHWAYS_20260510%WP5315%HOMO SAPIENS Sebaleic acid formation and metabolism FADS2 ALOX5 CYP4F3 FADS1 ACSL1 HEME BIOSYNTHESIS%WIKIPATHWAYS_20260510%WP561%HOMO SAPIENS Heme biosynthesis ALAS2 ALAS1 FECH HMBS UROD UROS CPOX ALTERED GLYCOSYLATION OF MUC1 IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260510%WP4480%HOMO SAPIENS Altered glycosylation of MUC1 in tumor microenvironment IKBKB TNF NFKBIA IL6 CHUK RELA IKBKG NFKB1 MUC1 BDNF SIGNALING IN NEURODEVELOPMENT%WIKIPATHWAYS_20260510%WP5541%HOMO SAPIENS BDNF signaling in neurodevelopment CREB1 DOCK7 TIAM1 MAP2K5 MAPKAPK2 HEL-S-47e MAPK8 PLCG1 MAPK3 ARHA ARHGAP35 BCL2 CTNNB1 CFL2 JUN PIK3CA HEL-S-15 WASL IQGAP3 IKBKB NFKBIA MAP3K1 CHUK TRADD TRAF6 MAPK1 IKBKG RAF1 ROCK1 ROCK2 HEL2 CDC42 LIMK1 PARD3 PRKCH PRKCB PRKCE PRKCA IRS1 SMPD1 APAF1 SH2B2 MAPK11 CASP8 BCL2L11 PRKCZ FADD PARD6B PARD6A FOXO3A PIK3CD RPS6KB1 RPS6KB2 MYC CYCS HRAS MAP2K2 YWHAQ HEL-S-1 SOS1 YWHAG MAP2K4 YWHAZ RTN4R PDPK1 SHC1 TCF7L2 LEF1 NPTX2 CRK SORT1 NGFR EIF4EBP1 NTRK2 STAT3 TCF7L1 MTOR KRAS EEF2 GRB2 TP73 RAPGEF1 MAPK7 LINGO1 KIDINS220 RAC1 BMP7 BDNF NRAS PAK1 FRS2 EEF2K BAD PTPN11 GSK3B EIF4E BAX CASP9 MAP3K5 PRKCI MAP2K1 PROSTAGLANDIN SIGNALING%WIKIPATHWAYS_20260510%WP5088%HOMO SAPIENS Prostaglandin signaling CSF1 IRF7 CCR2 IL1A PTGES IL12A TGFB1 IL1B CXCL9 AHR CXCL1 NFKB1 MMP9 CCL3 CCL2 IFNG TNF PYCARD IL6 NLRP3 PTGER4 AREG PTGER2 CXCL8 VEGFA IL17F IL17A KLRD1 IFNA1 DOWNREGULATION OF ACE2 BY SARS COV 2 SPIKE PROTEIN%WIKIPATHWAYS_20260510%WP4799%HOMO SAPIENS Downregulation of ACE2 by SARS CoV 2 spike protein ACE2 AGTR1 AGTR2 WNT SIGNALING AND PLURIPOTENCY%WIKIPATHWAYS_20260510%WP399%HOMO SAPIENS Wnt signaling and pluripotency PRKD1 EP300 PRKCZ FOXD3 PAFAH1B1 MAPK9 PTPA ZBTB33 CREBBP NR1C2 PPP2R2A PPP2R1B CCND1 PPP2R1A MYC NKD1 NKD2 FOSL1 ARHA PPP2R3B PPP2CA PPP2R3A CTNNB1 PPP2R2C PPP2R2B AXIN2 SOX2 CTBP1 LDLR NLK FRAT1 MAP2K4 DVL1 DVL2 JUN DVL3 WNT4 TCF7L2 POU5F1 LEF1 AXIN1 LRP5 CSNK1E FBXW2 CTBP2 PPM1J LRP6 WNT1 LRRK2 MAPK10 TCF7L1 WNT2B FZD10 APC MMP7 CTNND1 WNT5B WNT9B PPP2R5E PPP2R5C WNT16 FZD1 CD44 WNT3 WNT10B WNT10A FZD3 FZD2 FZD5 FZD4 WNT3A NFYA WNT7B FZD7 FZD9 WNT7A FZD8 GSK3B PRKCH PRKCB CCND3 MAP3K7 PRKCE PRKCA PRKCI CCND2 ESRRB PRKCQ 15Q13 3 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP4942%HOMO SAPIENS 15q13 3 copy number variation syndrome TRPM1 FANCD2 FYN MTMR10 OTUD7A GOLGA8R KLF13 CREBBP GOLGA8O GOLGA8Q ARHGAP11B GPR75 GRM6 GOLGA8H CHRFAM7A FAN1 CCL5 CHRNA7 KAT2B RETINOL METABOLISM%WIKIPATHWAYS_20260510%WP5188%HOMO SAPIENS Retinol metabolism BCO1 RPE65 RDH12 DHRS9 CYP2W1 AOX1 LRAT ADH1A CYP2A6 HEL-S-53e CYP1A1 DHRS4 CYP3A7 SDR16C5 AWAT2 PNPLA4 CIRCADIAN RHYTHM GENES%WIKIPATHWAYS_20260510%WP3594%HOMO SAPIENS Circadian rhythm genes CREB1 EP300 TPH2 CRH KCND2 PHLPP1 SKP1 PRKAA2 NONO SFTPC MAPK9 MAPK8 PRKDC JUND HNRNPD STAR DDC TH DBP MYBBP1A FBXW11 JUN SIK1 HDAC2 HDAC1 PPP1CC TCF2 SLC9A3 TOP2A SUV39H2 SUV39H1 CCAR2 EGR1 KMT2A NLGN1 SIN3A CRX PPARG CDK4 TYMS EZH2 ZFHX3 ROCK2 CHRM1 NPY2R ID3 NPAS2 RELB NPS ARNT2 HEL-S-2 DRD1 SIRT1 RPS27A DRD2 DRD3 NAMPT CHRNB2 UTS2R BTBD9 HCRTR2 HCRTR1 PER3 AgRP ADORA2A MTNR1B GHRH UBE3A UTS2 HOMER1 GHRL ADA TPH1 SFPQ NCOR1 PROK2 HEL-S-80p ID4 HDAC3 HS3ST2 AVP RORC PTEN NR2F6 RORA AHR ID2 AANAT HTR7 CPT1A FAS NR1H3 RAI1 NR1C1 TNFRSF11A DRD4 CRY1 NFIL3 PER2 SIX3 PROX1 NR1D1 MTTP PER1 CSNK1D CSNK1E NTRK1 NGFR CRY2 ADCY1 DYRK1A F7 NKX2-1 C1orf51 CRTC1 BTRC RORB PROK1 PML MAPK10 KCNH7 USP2 SOX14 CARTPT CLDN4 PSPC1 GNA11 TIMELESS NOS2 ATF5 SETX MAGEL2 THRAP3 BHLHB2 UBC OPN4 OPN3 MAGED1 FBXL3 KDM5A BHLHE41 HEBP1 RBM4 KLF10 PAX4 MC3R KCNMA1 NTRK3 PRF1 CIPC RBM4B ATOH7 PROKR1 NOCT ATF4 CAVIN3 LEP PASD1 CREM BMAL2 DDX5 IL6 METTL3 PRKAA1 GSK3B OGT MTNR1A KLF9 GFPT1 PPARGC1A NR1D2 EFFECTS OF MFN2 MUTATION%WIKIPATHWAYS_20260510%WP5443%HOMO SAPIENS Effects of MFN2 mutation MAP2 RAB3B TRAK1 ATAT1 RHOT1 DCTN1 KIF1B CASP8 RABAC1 DYNC2H1 DYNC1I1 DYNC1LI2 BAX RAB7A DYNC2I2 MFN2 SYPL1 CASP3 SNCA DYNC1H1 FAMILIAL HYPERLIPIDEMIA TYPE 1%WIKIPATHWAYS_20260510%WP5108%HOMO SAPIENS Familial hyperlipidemia type 1 APOA5 LIPC ANGPTL4 LPL APOA4 ANGPTL8 SEL1L ANGPTL3 PLTP LMF1 LDLR GPIHBP1 APOA2 APOC2 TGF BETA SIGNALING IN THYROID CELLS FOR EPITHELIAL MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260510%WP3859%HOMO SAPIENS TGF beta signaling in thyroid cells for epithelial mesenchymal transition CDH2 ID1 RUNX2 MAPK3 SNAI1 TNC HEL113 MAPK1 SMAD2 SMAD4 AKT3 CDH16 SNAI2 CDH6 AMP ACTIVATED PROTEIN KINASE SIGNALING%WIKIPATHWAYS_20260510%WP1403%HOMO SAPIENS AMP activated protein kinase signaling GYS1 PRKAA2 ACACA CDKN1A PLCB1 PIK3CD GYS2 CCNB1 RPTOR RPS6KB1 ACACB RPS6KB2 CPT1A TSC2 TSC1 PRKACG ADRA1B ADRA1A CCNA2 CRTC2 PIK3CA INS-IGF2 FASN EIF4EBP1 INSR MTOR ELAVL1 EEF2 PRKAB2 PRKAB1 CAMKK1 CAMKK2 LEP STK11 PIK3R3 SLC2A4 PIK3R2 PIK3R1 PPARGC1B LIPE ADIPOR2 PRKAG1 STRADA PRKAG2 EEF2K ADIPOR1 PRKAG3 CPT1C PRKAA1 SLC2A4RG CAB39 HMGCR NR2A1 LEPR STRADB FOCAL ADHESION PI3K AKT MTOR SIGNALING%WIKIPATHWAYS_20260510%WP3932%HOMO SAPIENS Focal adhesion PI3K Akt mTOR signaling CREB1 EIF4B PHLPP1 ANGPT4 CSF1 PRKAA2 IL2RG JAK3 ACACA MAPK3 PPP2R1B PPP2R1A IL2 PPP2R5B PPP2R5A PPP2R5D FGF2 XB PPP2R3A FGF7 PPP2R2C FGF8 PPP2R2B FGF9 F2R CRTC2 PIK3CA FGF20 TNC VEGFC FGF22 FGF21 IGF1 FGF16 SLC2A2 FGF14 FGF18 CSF3 FGF13 FGF12 FGF10 FGF8A FGF7B FGF7A PRLR FGF6B VEGFB SLC2A4 OSM FGF5C PRL GYS1 FOXA1 CDKN1A RAB11B FLT1 ITGA4 FLT4 PTEN PIK3CD ULK1 IGF1R RPTOR THBS2 AKT3 KDR MLST8 HRAS IL6R PDGFRA MAP2K2 ANGPT2 TSC2 TSC1 ANGPT1 HIF1A AKT1S1 IL2RB KIT SOS1 MET EPHA2 CSF1R IL2RA RAB8A EGFR ITGB3 FOXO1 ITGA6 ITGAV NGFR INSR MTOR RHEB MDM2 PPP2R5E NOS2 RAB10 KRAS GRB2 PPP2R5C FGFR4 COL4A2 FGFR3 FGFR2 FGFR1 HEL-S-125m THBS1 ITGA2 ITGB7 PIK3R2 PIK3R1 NRAS STRADA TCL1B SLC2A3 BAD TCL1A PELO HIF3A PHLPP2 COL11A2 CSHL1 GHB3 ITGB4 PFKFB1 CDKN1B PFKFB4 PPP2R3C PIK3IP1 PPP2R2D GYS2 GHR OSMR CDC37 PPP2CA VWF KPG_010 IRS4 LAMC1 ATF2 ITGB5 ITGAE ITGB8 CSF3R ITGA7 ITGA2B ELAVL1 RAB2A HSP90AB1 IKBKB ITGAM LPAR2 MAPK1 LPAR3 IKBKG LPAR4 RAF1 IFNA7 CHRM2 CHRM1 IFNAR2 ITGAX VEGFD IBSP IFNAR1 SPP1 COL4A1 COL4A4 IFNB1 COL4A6 NGF COL1A1 COL3A1 COL2A1 IL7R LAMC2 IRS1 PIK3R4 PIK3C2A INS PIK3C2B PIK3R5 LAMA1 LAMA4 LAMA3 LAMB3 LAMB2 LAMB1 RELN VTN GNG12 FOXO3A GNG11 GNG13 JAK1 RPS6 RPS6KB1 RPS6KB2 GNB2 GNB1 GNB4 GNB3 RAB14 EPO EPOR KITLG IL3RA ITGB6 GNGT1 COL1A2 PDPK1 EIF4EBP1 EGF GNG3 ITGB1 PDGFD LAMA5 GNG2 PDGFC HGF GNG5 PDGFA GNG4 EIF4E1B GNG7 GNG8 ATF6B CREB3L3 CREB3L4 CREB3L2 GNGT2 PFKFB2 COMP CREB3 TNR CREB5 ATF4 CHAD STK11 DDIT4 LIPE EFNA5 COL5A3 GNG10 EFNA4 COL5A2 EFNA1 PRKAA1 EFNA3 THBS4 THBS3 EFNA2 GSK3B CAB39 EIF4E LPAR1 VEGFA CASP9 MAP2K1 PPARGC1A PHOSPHOINOSITIDES METABOLISM%WIKIPATHWAYS_20260510%WP4971%HOMO SAPIENS Phosphoinositides metabolism INPP5D MTMR10 STM7 PLCH2 PLCD4 PLCG2 PLCG1 PLCB1 PTEN PIK3CD MTMR1 MTMR2 MTMR8 OCRL MTMR6 MTM1 PIP4P2 PLCH1 PLCB2 PIP4P1 PLCE1 SACM1L PIKFYVE PLCB4 PIP4K2A PLCD3 PIP4K2B PLCB3 PIK3CA PIP5K1A PIP5K1C MTMR3 MTMR12 PIK3R4 MTMR11 PIK3C2G MTMR9 PIK3C2A MTMR4 PIK3C2B SBF1 SBF2 GLYCOLYSIS IN SENESCENCE%WIKIPATHWAYS_20260510%WP5049%HOMO SAPIENS Glycolysis in senescence RB1 HEL-S-30 PRKAA1 HEL-S-133P ENO1 HEL-S-68p HEL-S-162eP MAMMARY GLAND DEVELOPMENT PREGNANCY AND LACTATION STAGE 3 OF 4%WIKIPATHWAYS_20260510%WP2817%HOMO SAPIENS Mammary gland development pregnancy and lactation stage 3 of 4 PTPN1 TFPI2 CLDN6 TTC9 PRL GAL HDGFL2 TPM3 BCL2L1 NR3C1 USF1 STAT5B EIF4G1 GJB2 CHUK NR3A2 CCND1 PGR MYC PRLR USF2 CEBPA YY1 TNFRSF11A CEBPB TNFSF11 NFIA ERBB4 EIF4E NRG1 CSN2 NFIB EGFR ELF5 ERBB3 ORAI1 ERBB2 DLGAP4 TNF RELATED WEAK INDUCER OF APOPTOSIS TWEAK SIGNALING%WIKIPATHWAYS_20260510%WP2036%HOMO SAPIENS TNF related weak inducer of apoptosis TWEAK signaling NFKBIB RELA CASP8 TRIM63 FADD MAPK9 MAPK8 MAPK3 TRAF1 IKBKB BIRC3 NFKBIA CHUK MAPK1 MAPK14 RAC1 RAF1 MAP3K14 NFKB1 TNF CTNNB1 TWEAK TRAF2 RELB TNFRSF12A TRAF5 TRAF3 BIRC2 RIPK1 GSK3B JUN NFKB2 MAP3K7 HDAC1 CASP3 METABOLISM OF ALPHA LINOLENIC ACID%WIKIPATHWAYS_20260510%WP4586%HOMO SAPIENS Metabolism of alpha linolenic acid FADS2 ALOX5 ALOX15 FADS1 ALOX12 PTGS2 GABA METABOLISM AKA GHB %WIKIPATHWAYS_20260510%WP4157%HOMO SAPIENS GABA metabolism aka GHB ALDH5A1 PON3 ADHFE1 GLS GLS2 GAD1 GAD2 ABAT HEL-S-166mP TRYPTOPHAN CATABOLISM LEADING TO NAD PRODUCTION%WIKIPATHWAYS_20260510%WP4210%HOMO SAPIENS Tryptophan catabolism leading to NAD production AADAT HAAO NMNAT1 IDO1 HEL-S-90n TDO2 NMNAT2 AFMID NMNAT3 NMRK2 NMRK1 NAPRT KYNU KMO NAMPT NADSYN1 FOLLICLE STIMULATING HORMONE FSH SIGNALING%WIKIPATHWAYS_20260510%WP2035%HOMO SAPIENS Follicle stimulating hormone FSH signaling CREB1 TSC2 MTOR FSHB RHEB SGK1 H3-4 FSHR CGA MAPK3 SRC PRKCA RPS6 RPS6KB1 RPS6KB2 MAPK14 FOXO1 MAPK1 RAF1 EIF4EBP1 APPL1 HYPOTHETICAL CRANIOFACIAL DEVELOPMENT PATHWAY%WIKIPATHWAYS_20260510%WP3655%HOMO SAPIENS Hypothetical craniofacial development pathway TFAP2A ARHGEF2 IRF6 TP63 ARHGAP29 ARHA HEART DEVELOPMENT%WIKIPATHWAYS_20260510%WP1591%HOMO SAPIENS Heart development NFATC2 FGF10 SHH NKX2-5 TBX20 BHLHB2 IRX4 TBX5 ISL1 TBX2 BMP4 FOXA2 SMYD1 HAND1 MAPK1 SMAD4 VEGFB PITX2 CTNNB1 BMP10 FGF8 SMAD1 FOXH1 NOTCH1 NFATC1 PTPN11 BMP2 HAND2 VEGFA NFATC3 BMPR1A FOXC2 FOXC1 VEGFC BMPR2 NFATC4 GATA4 ERBB3 HEY2 GATA6 TBX1 MEF2C HDAC6 INTERACTIONS IN THE CENTRAL NERVOUS SYSTEM%WIKIPATHWAYS_20260510%WP5426%HOMO SAPIENS HDAC6 interactions in the central nervous system EP300 DLG2 FUS DCTN1 HEL-S-67p PARK2 PRKCZ CSNK2A2 STUB1 GSK3A NR3C1 MAPK8 HEL-S-2a CSNK2B VCP HDAC9 MAPK3 HDAC11 IKBKAP FAT10 CYBB OPTN ITIH4 NEDD9 HEL113 KALRN ATXN3 SMAD2 HSF1 CCDC141 HSPA4 MAP1LC3A MIIP FOXP3 ARID3A GARS1 SP1 CNOT6 BCL2 TUBA1C CTNNB1 HDAC6 HEL-S-44 TUBB HIF1A MYD88 TUBA4A MIF MYH9 PXN TUBA2 POU5F1 EGFR HEL-S-102 HEL-S-32 KAT5 AURKA SNCAIP APC SHH ERG CFTR BIRC5 ADRBK1 SQSTM1 PTK2B MAPK1 SNCA RAC1 CD133 HEL-S-72p EP400 APOE BBIP1 BDNF RHOT1 SGK1 SIRT2 VHL GRIA2 GSK3B BAX HTT PRKCE FREP1 MAP3K5 TWIST1 DLG4 CDC20 MAP1B MAPRE1 ISG15 TARDBP PANCREATIC ADENOCARCINOMA PATHWAY%WIKIPATHWAYS_20260510%WP4263%HOMO SAPIENS Pancreatic adenocarcinoma pathway BRCA2 RELA BCL2L1 MAPK9 MAPK8 CDKN1A JAK1 MAPK3 TGFB1 PIK3CD STAT1 RPS6KB1 BRAF RPS6KB2 CCND1 SMAD2 SMAD4 AKT3 TGFBR1 dik MAP2K2 PIK3CA RB1 EGFR TGFA PAK6 PAK4 EGF STAT3 MAPK10 MTOR CDKN2A KRAS RAC3 CDK6 CDK4 IKBKB ARAF CHUK MAPK1 IKBKG RAC1 RAF1 POLK NFKB1 DDB2 CDC42 PIK3R3 PIK3R2 TGFBR2 PIK3R1 PAK1 E2F2 E2F3 BAK1 RALBP1 GADD45B BAD GADD45A GADD45G BAX VEGFA CASP9 PLD2 HEL-S-34 MAP2K1 RALA RALB ERBB2 RAD51 THYROXINE THYROID HORMONE PRODUCTION%WIKIPATHWAYS_20260510%WP1981%HOMO SAPIENS Thyroxine thyroid hormone production CREB1 MAP2K2 DUOX1 CLCN5 HEL-S-5 PRKAA2 DUOX2 TG PRKAA1 CGA TSHR RAP1A MAPK3 PRKCA TPO MAPK1 RAF1 MAP2K1 SLC5A5 NFKB1 TRH INTERACTIONS BETWEEN LOXL4 AND OXIDATIVE STRESS PATHWAY%WIKIPATHWAYS_20260510%WP3670%HOMO SAPIENS Interactions between LOXL4 and oxidative stress pathway IGFBP7 SUV39H1 FGF7 DDR1 EXOC6 HEL-S-7 SIRT1 PKD1 NRF1 BMP2 LOXL4 TGFB1 COL2A1 NFE2L2 NQO1 CDC37 ECSIT TRANSLATION INHIBITORS IN CHRONICALLY ACTIVATED PDGFRA CELLS%WIKIPATHWAYS_20260510%WP4566%HOMO SAPIENS Translation inhibitors in chronically activated PDGFRA cells EIF4B MAP2K3 MAPK10 MTOR MAP2K5 CSNK2A1 MAPK9 MAPK8 EIF4A2 MAPK3 EIF4G1 RPS6KA5 RPS6 RPTOR RPS6KB1 RPS6KB2 MAPK1 MAPK14 AKT3 MAP2K6 PIK3R3 MAP2K2 PIK3R2 PIK3R1 RPS6KA2 RPS6KA1 MAP2K4 EIF4E PIK3CA PIM1 PIM2 PRKCA RPS6KA4 MAP2K1 EIF4A1 EIF4EBP1 ESTRADIOL REGULATION IN PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260510%WP5235%HOMO SAPIENS Estradiol regulation in porto sinusoidal vascular disease CALM1 KCNN3 SP3 SP1 BUTYRATE INDUCED HISTONE ACETYLATION%WIKIPATHWAYS_20260510%WP2366%HOMO SAPIENS Butyrate induced histone acetylation ACLY PHOTODYNAMIC THERAPY INDUCED NF KB SURVIVAL SIGNALING%WIKIPATHWAYS_20260510%WP3617%HOMO SAPIENS Photodynamic therapy induced NF kB survival signaling CSF2 RELA REL IL1A BIRC5 IKBKB IL1B BIRC3 CHUK CD40LG TRAF6 CCND1 IL2 CXCL2 MMP2 NFKB1 MMP9 SELE BCL2L2 TNF VCAM1 RELB IL6 BIRC2 BCL2A1 PTGS2 CXCL8 VEGFA NFKB2 TNFRSF1A MMP3 EGLN2 CYTOSINE METHYLATION%WIKIPATHWAYS_20260510%WP3585%HOMO SAPIENS Cytosine methylation TET2 MBD3 TDG TET1 HEL-S-26 COMMON PATHWAYS UNDERLYING DRUG ADDICTION%WIKIPATHWAYS_20260510%WP2636%HOMO SAPIENS Common pathways underlying drug addiction CREB1 GNAI1 PS1TP5BP1 GRIA3 HEL-S-80p MAPK3 ARAF GJB1 CAMK4 MAPK1 RAF1 GNAS ACTG2 MAP2K2 CALM1 ACTG1 PRKACG DRD4 DRD1 PPP1R1A DRD2 GRIA2 RAP1A PRKCB PRKCA GRIN1 CAMK2A MAP2K1 GRIA4 ADCY1 PPP1CC ADCY8 EPITHELIAL TO MESENCHYMAL TRANSITION IN COLORECTAL CANCER%WIKIPATHWAYS_20260510%WP4239%HOMO SAPIENS Epithelial to mesenchymal transition in colorectal cancer CLDN6 MAP2K3 MAPK8 JAG2 DLL3 MAPK3 DLL4 TGFB1 FMNL2 JUP MAPK14 SMAD2 SMAD4 CLDN11 FOXM1 CLDN7 CTNNB1 TUSC3 HEL-S-79 CLDN2 CDKL2 CLDN3 CLDN9 PKP1 EIF5A2 CLDN22 WNT4 CLDN20 PIK3CA CLDN24 NRP2 CLDN23 CLDN10 CLDN15 CLDN14 CLDN19 STRAP CLDN18 CLDN17 CLDN16 CLDN1 TMPRSS4 RBBP4 GDF15 NUBPL CRB3 SUZ12 WNT2B FZD10 PKD1 EED WNT5B NOTCH3 WNT9B WNT9A WNT16 WNT8A WNT8B MEF2D EZH2 WNT3 WNT10B WNT10A FZD3 FZD2 FZD5 TRAF6 FZD4 MAPK1 WNT3A RAF1 WNT7B FZD7 FZD9 MAP2K6 MAPK13 WNT7A FZD8 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 TWIST2 FOXC2 TWIST1 ZEB2 SNAI2 MAPK12 MAPK11 VTN PIK3CD ID2 AKT3 PALS1 HRAS TGFBR1 PKP2 MAP2K2 FOXQ1 HIF1A PROX1 MMP15 SOS1 SOS2 MAP2K4 SHC1 LRP5 RBPJ LRP6 WNT1 TJP1 SPARC CDH2 CLDN4 KRAS FZD1 GRB2 ID1 COL4A2 SNAI1 MMP2 MMP9 PIK3R3 PIK3R2 PIK3R1 TGFBR2 PAK1 NOTCH2 NOTCH1 GSK3B CLDN5 LATS2 NR2C2 MAP2K1 CTDSP1 MITOCHONDRIAL COMPLEX II ASSEMBLY%WIKIPATHWAYS_20260510%WP4920%HOMO SAPIENS Mitochondrial complex II assembly SDHAF2 SDHB SDHAF3 SDHAF1 SDHAF4 SDHC SDHD SDHA EFFECT OF INTESTINAL MICROBIOME ON ANTICOAGULANT RESPONSE OF VITAMIN K ANTAGONISTS%WIKIPATHWAYS_20260510%WP5273%HOMO SAPIENS Effect of intestinal microbiome on anticoagulant response of vitamin K antagonists NPC1L1 NR1C2 SCARB1 NR1i2 CYP2C9 NR1C1 CD36 NR1i1 PROTEASOME DEGRADATION%WIKIPATHWAYS_20260510%WP183%HOMO SAPIENS Proteasome degradation PSMB6 PSMB2 PSMB3 PSMC1 HEL-S-276 UBE2D2 PSMD10 PSMD7 RPN2 RPN1 UBE2D1 HLA-B PSMB10 HLA-C PSMD5 UBE2B HLA-F UBC HLA-E HEL-S-283 PSMD12 PSME2 HEL-S-91n PSMD13 HIST1H2AB HEL-117 UBB HLA-G H2AZ1 PSMD11 UBE2D3 PSMC6 PSMC4 IFNG NEDD4 PSMD2 H2AX PSMA4 PSMD9 PSMD6 HLA-A PSMD4 PSMD3 PSMD1 PSMB8 UBA7 PSMA2 GIP AND GLP 1 FUNCTION BY TISSUE%WIKIPATHWAYS_20260510%WP5509%HOMO SAPIENS GIP and GLP 1 function by tissue GCG GIP MIR TARGETED GENES IN LYMPHOCYTES%WIKIPATHWAYS_20260510%WP2004%HOMO SAPIENS miR targeted genes in lymphocytes GPD2 GAS2L1 PKN2 POLE4 POLA2 MAP3K8 CBFB MAPK14 IGF2R FGF2 BCL2 CTNNB1 TNFRSF10B LPL AP2A1 ELOVL5 DNAJB1 FADS2 FADS1 HEL-S-26 SUCLG2 RAB27B KCNN4 NT5C3A PICALM HEL-S-30 MBNL1 GNA13 MRM1 CHAF1A RAB23 BACE1 NRP1 GYS1 BCL6 CDKN1A CCND1 PPP3CA PPP1R7 SH3BP4 SDCBP VCAM1 TUBA1A CXCL12 KIT MET CPNE8 NCL VEZT TMEM41B BACH1 PWP1 CSNK1D RAVER2 EGFR CIAO2A SEC62 HEL-S-303 CACNA2D1 FNDC3B FNDC3A MTRR CARHSP1 HEL-S-273 WDR82 FAR1 HACD3 ARL10 UBE2J1 COMMD9 GRPEL2 ATP6V1C1 MOV10 RHEB NCEH1 PDE3A STRN KRAS ANP32B PPP2R5C GFM1 MAGT1 PANX1 COL4A2 PTPRF COIL SERPINE2 SERP1 RDH10 C1QBP PLXND1 GNPNAT1 TUSC2 MAPK7 TMED7 ARID4B DCAF7 MRPS24 IGF2BP1 ELMOD2 TXN2 PNP TMT1A CHORDC1 AP3B1 PDLIM7 GOLGA7 CDK5RAP3 CSDE1 ARHG VPS39 PXDN ATP6V0E1 AMIGO2 TNLG5A ITGA2 IFRD1 RHOB NAPG NT5E HEL-S-66 PISD MPZL1 RNP24 SPRYD4 RAB34 TTC9C PPIF POM121 TPPP3 BDNF ATAT1 GPAM DDX5 NFIA RAB5C NEDD4 SLC1A4 SNX15 ADIPOR2 LAMTOR5 RTN4 LTN1 CORO1C E2F3 MRPL20 CPOX ABHD10 SAC3D1 POGLUT3 MPDU1 TCL1A KPNA3 ATP6V1F SNX6 SLC38A1 RARS1 CD164 PHC2 TPM1 STX7 BRPF3 UBE4A TBCA CDKAL1 MENT SFXN1 RAB30 CDKN1B SYPL1 SLC25A1 ARF4 PTMAP7 SLC12A2 TRAM1 GEMIN7 SRSF9 ABCG2 TMED10 ADPGK RAI14 TNFAIP2 ADAR LMNB2 TM6SF1 GFPT1 SNAP23 MRC2 SLC4A10 TMEM43 SPCS3 GNL3L TMED3 CHMP2A SRPRB TMEM109 CYP51A1 SH3BGRL3 DKFZp761E1322 POLD2 CALCOCO2 ACP2 NELFCD DOCK7 CTSC CYR61 SYNE2 SCYL1 SLC7A6 SYNE1 CDCP1 HEL-S-108 HSDL1 RFT1 FRG1 RCN2 PTRH1 RBMS1 UNC93B1 ANAPC1 SEC23A HEL-S-47e PTPA LUZP1 CYP1B1 SHOC2 NUFIP2 NXN CDIPT HSD17B12 AP3D1 ARCN1 ATG9A CAND1 WDR11 TDG TP53INP1 FMNL2 ZNF622 SLC25A24 GALNT7 NHERF2 GALNT1 SLC4A7 SLC25A32 PLK1 BET1 SPTLC1 ATG3 DHX15 CDKN1C PRPF40A SMC1A SMAD1 USP1 FXR2 FBXW11 RB1 MTHFD2 SRSF10 GSTM4 DNMT3B LAMC1 CLDN1 TPM3 ANXA2 CDKN2A PPP5C ARID1A EHMT1 CDK6 PRIM1 RRP8 TYMS DHX57 EZH2 LOC541469 IQGAP3 LAMTOR3 HOXA5 PGRMC1 OTULINL CEP72 POLR2C VTI1B HARS1 BRI3BP PEDS1-UBE2V1 FERMT2 HOXD8 RCOR1 MEOX2 VAMP3 MRPS33 TAF9B MTX1 TRMT1 TMEM59 CEBPB TRIP13 CAP1 LY6K GEMIN2 MSI2 ABHD11 PLAG1 NARS1 DOCK5 ARID2 NPRC TNFRSF10A TRPV6 UBE2S UTP15 MARS2 RBM19 SIGMAR1 ABCF2 SLC25A22 SNAP29 LAMC2 IRS1 ASH2L MCL1 MAPK12 HMOX1 SSNA1 SLC25A13 CUL4B AXL MYLIP ATP2A2 RQCD1 YWHAQ P4HA2 PPIB MYO1E HMGA1 PSAT1 PPP3R1 AKAP8 TGFBR2 PURA NOTCH2 NOTCH1 TERT NF2 EIF4E AURKB PRKCI PTBP1 MYB UHRF1 TRANSCRIPTION FACTORS REGULATE MIRNAS RELATED TO CARDIAC HYPERTROPHY%WIKIPATHWAYS_20260510%WP1559%HOMO SAPIENS Transcription factors regulate miRNAs related to cardiac hypertrophy PPP3R1 TGFB1 STAT3 RASGRF1 MYEF2 NFKB1 S1P RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20260510%WP26%HOMO SAPIENS S1P receptor signal transduction GNAI1 SPHK1 MAPK12 MAPK6 S1PR5 MAPK4 SMPD2 PLCB1 MAPK3 PLCB3 MAPK7 S1PR1 SPHK2 S1PR3 MAPK1 S1PR2 AKT3 PLCB2 GNAI3 PIK3C2B CELL DIFFERENTIATION EXPANDED INDEX%WIKIPATHWAYS_20260510%WP2023%HOMO SAPIENS Cell differentiation expanded index LEFTY1 TLX3 STAT3 TLX2 TLX1 SOX2 RUNX2 MEF2D LEFTY2 KLF4 EZH2 MYOD1 PAX7 ID2 MEF2C HDAC5 MEF2B IL17 SIGNALING%WIKIPATHWAYS_20260510%WP2112%HOMO SAPIENS IL17 signaling STAT3 NFKBIB RELA MAPK3 JAK1 IKBKB TRAF6 TRAF3IP2 MAPK1 IKBKG MAP3K14 NFKB1 SP1 CEBPD IL17B CEBPB IL25 TRAF3 IL17RC GSK3B PIK3CA IL17F IL17D MAP3K7 IL17RB IL17C IL17A IL17RA MIR 517 RELATIONSHIP WITH ARCN1 AND USP1%WIKIPATHWAYS_20260510%WP3596%HOMO SAPIENS miR 517 relationship with ARCN1 and USP1 ARCN1 ID2 USP1 ID1 CDKN1A EICOSANOID SYNTHESIS%WIKIPATHWAYS_20260510%WP167%HOMO SAPIENS Eicosanoid synthesis PLA2G4B ALOX15 PTGIS PRXL2B PTGS2 PTGS1 ALOX5AP PTGES LTC4S PLA2G5 ALOX15B ALOX5 PLA2G6 ALOX12 PHOSPHODIESTERASES IN NEURONAL FUNCTION%WIKIPATHWAYS_20260510%WP4222%HOMO SAPIENS Phosphodiesterases in neuronal function CREB1 ADCY6 PDE3A GUCY1A2 PDE6D PDE6A PDE6G PDE4B PDE4A PDE8A PDE4D GUCY1B1 PDE1C PDE1B CHRNA7 PDE1A PDE5A PPP1R1B DRD1 DRD2 PRKG1 PDE7B PDE7A HEL-S-7a ADORA2A PDE3B PDE11A GRIN2B PDE6C GRIN1 PDE6H CAMK2A PDE2A ADCY9 PDE10A PDE12 ADCY3 PDE9A ADCY1 ADCY8 NAD METABOLISM%WIKIPATHWAYS_20260510%WP3644%HOMO SAPIENS NAD metabolism NMNAT1 SIRT5 NMNAT2 NMNAT3 SIRT1 SIRT2 SIRT3 NAMPT NADK PARP1 SIRT7 NRK SIRT6 NT5E SIRT4 GENETIC CAUSES OF PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260510%WP5269%HOMO SAPIENS Genetic causes of porto sinusoidal vascular disease DOCK6 CYBC1 COX4I2 CXXC5 CHCHD2 C4orf54 BEND6 GTF2I EFL1 SHCBP1 ARHGAP31 NCF1 IBTK NCF2 EIF6 SBDS NCF4 MAPK3 DLL4 CYBB CYBA MAPK1 BTK RAC1 NFKB1 SP1 CDC42 KCNN3 NOTCH1 TLR8 NOX3 DGUOK RBPJ TLR9 4 HYDROXYTAMOXIFEN DEXAMETHASONE AND RETINOIC ACIDS REGULATION OF P27 EXPRESSION%WIKIPATHWAYS_20260510%WP3879%HOMO SAPIENS 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression MAP2K2 PIK3R3 MAP2K3 PIK3R2 TSC2 PIK3R1 TSC1 MTOR MAP3K11 PRKAA1 HEL164 EIF4E MAPK3 PIK3CA PIK3CD MAPK1 MAP3K5 RAF1 MAP2K1 MAP2K6 EIF4EBP1 AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20260510%WP699%HOMO SAPIENS Aflatoxin B1 metabolism CYP1A2 GSTM1 CYP2A13 EPHX1 CYP3A4 HEL-S-166mP LEPTIN INSULIN SIGNALING OVERLAP%WIKIPATHWAYS_20260510%WP3935%HOMO SAPIENS Leptin insulin signaling overlap INSR PIK3R3 DGKZ STAT3 SOCS2 SOCS3 PDPK1 IRS4 IRS1 INS SOCS1 LEPR LEP SARS COV 2 AND ACE2 RECEPTOR MOLECULAR MECHANISMS%WIKIPATHWAYS_20260510%WP4883%HOMO SAPIENS SARS CoV 2 and ACE2 receptor molecular mechanisms ACE2 AGTR1 TMPRSS2 REN MGRA ENDODERM DIFFERENTIATION%WIKIPATHWAYS_20260510%WP2853%HOMO SAPIENS Endoderm differentiation NR1B3 MAP2K3 ACACA ZFHX4 CAND1 TGFB1 PAX3 DUSP2 SMAD2 SMAD4 TOX3 CTNNB1 TCF4 TET1 DKK1 SFRP1 SIAH2 BCORL1 BMPR1A HOXC11 CTBP2 DNMT3B LAMC1 GATA4 DUSP5 LHX1 MAD2L2 TCF2 PTHLH ELAVL1 WNT8A EZH2 WNT3 TOX AEBP2 MIXL1 APP SLC2A12 PABPC1 PIAS1 FOXA1 NODAL SOX17 CER1 NR3C1 SOX21 CEP250 SOX7 WDHD1 SFMBT1 CDYL VAV3 EMSY STAT1 RFX7 PBX3 RAB38 ATP8B2 CUL4B WDFY2 CTR9 PRDM14 RTF1 MBTD1 PLCH1 EPB41L5 LRPPRC CEBPZ UBR5 BPTF FOXN3 GDF3 TRERF1 OTX2 SP4 NABP2 PAF1 TAF4B TRIM71 ONECUT1 SOX2 PHF6 CDC73 NOG FOXH1 HHEX ZIC3 TBX21 NLK TRIM5 DUSP4 PARP8 EXT1 Pax9 AHDC1 BTAF1 TCEAL2 POU5F1 LEO1 LEF1 KDM4A ZNF462 ELP4 ZIC5 FOXO1 TNRC6C TAF5 HPRT1 NKX2-1 CRTC1 TCF7L1 APC PBX1 JARID2 FOXA2 C1QBP RGS10 WWC1 BMP7 HOXA1 SESN1 NOTCH1 GATA6 IL19 SIGNALING%WIKIPATHWAYS_20260510%WP5422%HOMO SAPIENS IL19 signaling STAT3 TNF CCL11 MAPK8 IL4 COL1A1 MAPK3 JAK1 TGFB1 STAT1 CCNB1 MAPK14 TNFRSF1A MAPK1 CXCR4 IL19 RAC1 IL20RA MUC5AC IL20RB NFKB1 ACTA2 SOCS1 SOCS5 ETHANOL EFFECTS ON HISTONE MODIFICATIONS%WIKIPATHWAYS_20260510%WP3996%HOMO SAPIENS Ethanol effects on histone modifications MTR SLC19A1 HDAC7 HDAC3 TYMS HDAC9 ACSS2 ADH1C HEL-S-117 ADH1A HAT1 ALDH2 HEL-S-53e CYP2E1 DHFR HDAC5 HDAC8 HDAC6 ALDH1A2 MAT1A HDAC2 HDAC1 HDAC10 ATF2 ALDH1A3 KAT2B TYROSINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260510%WP4506%HOMO SAPIENS Tyrosine metabolism and related disorders GSTZ1 HPD GLP 1 IN PANCREATIC ISLET CELLS%WIKIPATHWAYS_20260510%WP5447%HOMO SAPIENS GLP 1 in pancreatic islet cells SLC2A2 GCG IL6 INS GLP1R IL6R CLASSICAL PATHWAY OF STEROIDOGENESIS WITH GLUCOCORTICOID AND MINERALOCORTICOID METABOLISM%WIKIPATHWAYS_20260510%WP4523%HOMO SAPIENS Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism HSD11B1 HSD11B2 POR CYP21A2 CYP11A1 CYP17A1 HSD17B3 SRD5A2 HSD3B2 HSD3B1 CYP11B2 STAR H6PD TELOMERE END PACKAGING AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260510%WP5567%HOMO SAPIENS Telomere end packaging and neurodevelopmental disorders H2AB1 ACD TINF2 TERF1 POT1 H2AJ H2AC19 H2AC14 H2BC26 H3-4 H2BC12L H2BC21 HIST1H2AB H2AC6 H2BC17 H2BC12 H2BC13 H2AZ1 H2BC14 H4C9 H2BC15 H2BC11 HIST1H4L HIST1H2BE TPP1 H2BC9 TERF2 H2BC8 H2BC3 H2BC1 H2AC20 TERF2IP H2AX H2AZ2 CARDIAC HYPERTROPHIC RESPONSE%WIKIPATHWAYS_20260510%WP2795%HOMO SAPIENS Cardiac hypertrophic response PRKD1 MAP2K3 MAP2K5 CDK9 MAPK8 HDAC9 MAPK3 TGFB1 MAPK14 PPP3CA FGF2 TGFBR1 HDAC5 CDK7 MAP2K2 CALM1 MAP2K4 PDPK1 NRG1 CAMK2D IGF1 IKBKE NFATC2 EGF GUCA1A MTOR PLA2G2A MAP4K1 HDAC7 FGFR2 IKBKB MAPK7 MAP3K1 CHUK MAPK1 IKBKG RAC1 RAF1 MAP3K14 NFKB1 MAP2K6 TNF PRKG1 GSK3B MAP3K7 PRKCA TNFRSF1A NPPA MAP2K1 HSPB3 IN CHARCOT MARIE TOOTH DISEASE%WIKIPATHWAYS_20260510%WP5524%HOMO SAPIENS HSPB3 in Charcot Marie Tooth disease DMPK HP1BP3 HSPB3 NOTCH3 MYOG HSPB2-C11orf52 tmp_locus_29 MYOD1 H2AZ1 HEL25 ACTA1 LMNA MEF2C LBR AMINO ACID METABOLISM PATHWAY EXCERPT HISTIDINE CATABOLISM EXTENSION%WIKIPATHWAYS_20260510%WP4661%HOMO SAPIENS Amino acid metabolism pathway excerpt histidine catabolism extension GLUD1 FTCD HAL UROC1 GPT2 RUBINSTEIN TAYBI SYNDROME 1%WIKIPATHWAYS_20260510%WP5367%HOMO SAPIENS Rubinstein Taybi syndrome 1 CREB1 CREBBP NPAS2 PCNA MAFG FOXO1 SMAD4 FBL HEL23 IRF2 DDX21 MET IN TYPE 1 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260510%WP4205%HOMO SAPIENS MET in type 1 papillary renal cell carcinoma JAK3 MAPK8 CDKN1A PLCG1 MAPK3 PIK3CD BRAF AKT3 KDR HRAS MAP2K2 CRKL SOS1 RPL11 SOS2 INSL3 MET JUN PIK3CA SRC ALK CRK ELOA CBL PAK6 PAK4 STAT3 HGF KRAS STRN GRB2 C8orf34 RAPGEF1 ARAF MAPK1 RAC1 RAF1 CDC42 PIK3R3 PIK3R2 PIK3R1 NRAS PAK1 BAD PTPN11 RAP1A VEGFA MAP2K1 PRCC EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP581%HOMO SAPIENS EPO receptor signaling EPOR MAP2K2 STAT3 PTPRC GRB2 SOS1 PTPRU CISH MAPK3 STAT5B SHC1 SRC STAT1 IRS1 MAPK1 RAF1 MAP2K1 SOCS1 EPO FLUOROPYRIMIDINE ACTIVITY%WIKIPATHWAYS_20260510%WP1601%HOMO SAPIENS Fluoropyrimidine activity DPYS UCK2 UCK1 TYMP TYMS FPGS UPP2 TDG GGH DPYD ERCC2 UMPS CYP2A6 RRM1 RRM2 DHFR SLC22A7 CES2 CES1 ABCC3 ABCC5 CDA TK1 SMUG1 SLC29A1 ABCG2 XRCC3 PDGF PATHWAY%WIKIPATHWAYS_20260510%WP2526%HOMO SAPIENS PDGF pathway STAT3 WASL TIAM1 PDGFA GRB2 MAPK8 VAV2 PLCG1 MAPK3 JAK1 NFKBIA MAP3K1 STAT1 VAV1 CHUK MAPK1 RAC1 RAF1 NFKB1 ARHA HRAS CDC42 PIK3R1 PAK1 COX2 PTPN11 SOS1 MAP2K4 JUN SHC1 SRC MAP2K1 FOS ATOPIC DERMATITIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260510%WP5538%HOMO SAPIENS Atopic dermatitis mechanism and therapies STAT3 IL25 IL2RG JAK3 IL13RA1 IL13 IL4 IL1RL1 FCER1G MS4A2 CRLF2 IL33 OSMR TSLP IL5 TYK2 FCER1A SOMATIC SEX DETERMINATION%WIKIPATHWAYS_20260510%WP4814%HOMO SAPIENS Somatic sex determination WT1 CTNNB1 FOXL2 NR5A1 FGF9 DMRT1 DHH SOX9 SOX8 RSPO1 WNT4 GATA4 SRY AMH B CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP23%HOMO SAPIENS B cell receptor signaling CREB1 INPP5D GAB2 RELA BCL6 GTF2I TEC GSK3A MAPK9 MAPK8 PLCG2 PLCG1 LYN CARD11 SYK BCL10 BRAF BTK MAPK14 MYC HRAS MAP2K2 CD79A LCK PTPRC CD19 CRKL SOS1 NCK1 PDPK1 JUN SHC1 HCLS1 NFATC3 PIP5K1A PIP5K1C CRK FOXO1 CAMK2A ATF2 CD81 CBL NFATC2 FYN PTPN6 STM7 REL CD79B MAX GRB2 VAV2 MAP4K1 RAPGEF1 IKBKB NFKBIA VAV1 CHUK LAT2 DAPP1 MAPK1 PTPN18 IKBKG TIEG2 RAC1 RAF1 PIK3AP1 BLK NFKB1 MAP2K6 CDC42 PIK3R2 PIK3R1 MAPK4 CR2 RPS6KA1 PTPN11 GSK3B PRKCB MAP3K7 RASGRP3 BLNK MAP2K1 CD22 METABOLIC REPROGRAMMING IN PANCREATIC CANCER%WIKIPATHWAYS_20260510%WP5220%HOMO SAPIENS Metabolic reprogramming in pancreatic cancer DLAT GLS2 SLC7A5 KRAS CARM1 RPIA GNPNAT1 GLUD1 PGM3 DLD HEL-S-30 HEL-S-133P RPE GPT SLC16A4 GOT2 ME1 SOAT1 PDHX LDLR BCAT2 PFKL HMGCR FASN PDHA1 HEL-S-32 GFPT1 CS HK2 ACLY IL7 SIGNALING%WIKIPATHWAYS_20260510%WP205%HOMO SAPIENS IL7 signaling MAP2K2 STAT3 PIK3R2 PIK3R1 IL7 FYN IL2RG JAK3 BAD GSK3B MAPK3 JAK1 STAT5B STAT1 PTK2B IL7R MAPK1 MAP2K1 LIPID PARTICLES COMPOSITION%WIKIPATHWAYS_20260510%WP3601%HOMO SAPIENS Lipid particles composition APOE APOB LPL APOA2 LDLR APOC3 APOC2 1Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP4905%HOMO SAPIENS 1q21 1 copy number variation syndrome PRKAA2 BCL9 FMO5 KIRREL1 PRKAB2 PRKAB1 F11R ACP6 AFDN AMELX NBPF12 CHD1L PYGO2 CTNNB1 PRKAG1 GJA1 PYGO1 TJP3 PRKAG2 GJA3 PRKAA1 PRKAG3 GJA5 GJA8 TJP1 MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20260510%WP129%HOMO SAPIENS Matrix metalloproteinases MMP7 TIMP1 MMP14 MMP2 MMP9 TNF TCF20 MMP21 MMP20 MMP26 hEMMPRIN MMP25 TIMP4 MMP24 MMP23B MMP27 MMP10 MMP11 MMP16 TIMP3 MMP15 MMP17 MMP19 MMP28 MMP3 MMP12 LIVER X RECEPTOR PATHWAY%WIKIPATHWAYS_20260510%WP2874%HOMO SAPIENS Liver X receptor pathway CYP7A1 ABCG8 ABCG5 RXRA SCD FASN CYP2B6 CYP3A4 NR1H3 SPLICING FACTOR NOVA REGULATED SYNAPTIC PROTEINS%WIKIPATHWAYS_20260510%WP4148%HOMO SAPIENS Splicing factor NOVA regulated synaptic proteins CADM1 CDH2 PRKCZ MAPK9 AGRN CAMK2G CSN3 KCNJ6 GRIK2 ATP2B1 GABBR2 KCNMA1 GABRG2 GPHN MAPK4 PLCB4 EFNA5 CHL1 EPB41L3 KCNQ2 NCDN RAP1GAP NEO1 NTNG1 TERF2IP CADM3 SNW1 DAB1 STX2 MAP4 CAV2 GRIN2B CLASP1 GRIN1 CASK INSULIN SIGNALING%WIKIPATHWAYS_20260510%WP481%HOMO SAPIENS Insulin signaling ARF1 MAP2K3 MAP2K5 PRKAA2 MAPK9 MAPK8 MAP3K8 MAPK3 GYS2 ARF6 GYG1 MAPK14 SNAP25 STXBP1 SOCS1 INPP4A VAMP2 JUN PIK3CA IRS4 HEL-S-61 CBLC RPS6KA4 MAP3K13 MAP3K12 FLOT1 FLOT2 PTPN1 HEL-S-42 EGR1 MAP3K11 GRB10 IKBKB MAP3K1 MAPK1 RAF1 RAB4A MAP3K14 TRIB3 MAP2K6 MAPK13 PFKM TBC1D4 SLC2A4 MAPK6 CAP1 MAPK4 SGK1 KIF3A PRKCH INPPL1 PRKCB MAP3K7 PRKCA MYO1C IRS1 PIK3R4 PIK3C2G PIK3C2A XBP1 PRKCQ RPS6KA3 SH2B2 MAPK12 GYS1 MAPK11 PRKCZ STX4A GSK3A FOXO3A PTEN PIK3CD IGF1R RPS6KB1 RPS6KB2 HRAS MAP2K2 TSC2 TSC1 SOCS3 SOS1 SOS2 MAP2K4 PDPK1 SHC1 CRK FOXO1 SHC3 CBL EIF4EBP1 INSR MAPK10 MTOR RHEB GRB2 MAP3K2 MAP4K1 PTPRF MAP4K2 MINK1 RAPGEF1 MAPK7 RPS6KA5 MAP4K3 RAC1 SHC2 PIK3R3 MAP3K6 PIK3R2 PIK3R1 MAP3K10 LIPE RPS6KA6 RPS6KA2 RPS6KA1 PRKAA1 ENPP1 GRB14 PTPN11 STXBP3 STXBP4 GSK3B RRAD EIF4E PPP1R3A PFKL EHD1 EHD2 HEL-S-31 SGK2 SNX26 MAP3K5 PRKCI MAP2K1 SNAP23 FOS VITAMIN D RECEPTOR PATHWAY%WIKIPATHWAYS_20260510%WP2877%HOMO SAPIENS Vitamin D receptor pathway NINJ1 S100A4 COL13A1 EPHB4 KLK6 CRACR2A CRACR2B DND1 KRTAP4-1 SLC37A2 PRDM1 KRTAP12-2 KRTAP8-1 PNOC CLPTM1L S100A6 ALPG ZNF257 CD200 ORM1 IL12A ORM2 TGFB1 CASP14 DUSP10 ADGRE5 IGFBP1 CASP5 DACT2 KRTAP5-1 CA9 ABCD1 CAMP IGFBP5 KRTAP5-4 KRT34 CEACAM1 KRT38 SATB1 HEL57 CDK2 SEMA3B THBD ASAP2 CST1 CLMN IL25 CREG2 LRRC25 S100G KRTAP10-2 TNFAIP3 KRTAP10-4 CLDN2 KRTAP10-7 KRTAP10-9 SFRP1 KRT13 BMP6 MYO9B DEFB132 KRT16 CD9 CD14 FGF23 HLA-DRB1 CDKN2D CDKN2B CDKN2C S100A9 PTHLH KL CDKN2A PTH CYP2B6 KNG1 CYP27B1 BDKRB1 CYP24A1 KLF4 ITGAM CYP2S1 SLC2A4 SLC8A1 BGLAP SULT1C2 SPP1 CYP3A4 TRPV6 STEAP4 CYP2C9 CD40 COLEC11 ALPI PRKCQ BCL6 ADRB2 ID4 CDKN1A MED9 TREM1 NR1C2 CCND1 SALL4 MYC DEFB4B CLEC16A TNFRSF11B CYP7A1 TNFSF11 IRF4 RXRA HIF1A ADRA1B ABCB1 HLA-DQA2 HLA-DQA1 LRP5 ALOX5 FOXO1 DNER CST6 IRF8 LGALS9 NFATC2 CBS CTLA4 CDX2 TRPV5 S100A2 HNF1A ID1 MXD1 IL1RL1 HSD17B2 ATP2B1 S100A8 CYP1A1 SPRR1B SOSTDC1 CEBPA NR1i1 MX2 TRAK1 EFNA5 PTGER4 TNLG2B GADD45A ADAMTS5 TIMP3 TPM1 G0S2 CDKAL1 BTLA CDKN1B CCNE1 LPGAT1 CCNC JUNB HILPDA GXYLT2 STS SULT2A1 KRT71 SLC34A2 LCE1F LCE1D LCE2B CDC34 8P23 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP5346%HOMO SAPIENS 8p23 1 copy number variation syndrome TLR4 S100A10 NUMA1 TBX5 SOX7 MAPK3 ERI1 MTMR8 MTMR6 CTNNB1 NKX6-1 MCRS1 PDX1 BMP1 PINX1 HEPACAM2 CLDN23 SLC35G5 TNKS PRSS55 AXIN1 PPP1R3B CSTA MSRA PRSS51 NEIL2 DEFB136 C8orf74 DEFB135 DEFB134 CGAS GATA4 RP1L1 MFHAS1 FAM167A XKR6 FCGR2B TERF1 FCGR2A HSPD1 MAPK1 RAF1 BLK SLC2A4 HEL-S-130P TERT SLBP SGPL1 MTMR9 FDFT1 IRINOTECAN PATHWAY%WIKIPATHWAYS_20260510%WP229%HOMO SAPIENS Irinotecan pathway BCHE CES2 UGT1A10 CES1 SLCO1B1 ABCG2 ABCC2 UGT1A1 UGT1A9 CYP3A4 ABCC1 COMPLEMENT SYSTEM%WIKIPATHWAYS_20260510%WP2806%HOMO SAPIENS Complement system C5AR2 CFI C5AR1 LAMB1 CFP C2 VTN SFTPA2 ADM C6 C7 CRP C9 CD59 PTX3 SFTPA1 CD55 HEL-S-62p FCGR3A CLEC4M CD19 ICAM2 ARRB2 SELL DCN PLAUR RPS19 KLKB1 F13A1 SELP ITGB3 LAMC1 GNAI3 FGA CSNK1A1 VSIG4 HEL-S-99n ITGA2B CD93 PLG HEL-S-92n FCER2 FKBP2 HEL-S-78p LAMA5 FPR1 ALB ELANE F11 CFHR2 CFHR4 C1QBP TXN CPN1 FCN1 FCN2 PROS1 C4BPA THBS1 SELPLG C8A ITGA2 WAS C4A SELE C3AR1 MBL2 CR2 GNA15 F10 IBSP CR1 SPP1 CD40 SERPING1 MASP2 MASP1 CD46 PRKCA PRNP CFD C1S CFH CALORIC RESTRICTION AND AGING%WIKIPATHWAYS_20260510%WP4191%HOMO SAPIENS Caloric restriction and aging MTOR PRKAB2 SIRT1 NAMPT IGF1 PPARGC1A CAFFEINE IN BLOOD VESSELS%WIKIPATHWAYS_20260510%WP5601%HOMO SAPIENS Caffeine in blood vessels MYLK CALM1 ADCY6 RYR2 ADRA1D ADRA1B ADRA1A RYR3 PDE3A GUCY1A2 PPP1R12C HEL-S-80p ADORA2A PDE3B PDE4B PDE4A PDE4D ADCY9 ADORA2B ADCY3 ADCY1 ADCY8 DISORDERS OF MITOCHONDRIAL HOMEOSTATIS DYNAMICS PROTEIN IMPORT AND QUALITY CONTROL%WIKIPATHWAYS_20260510%WP5504%HOMO SAPIENS Disorders of mitochondrial homeostatis dynamics protein import and quality control MCL1 HTRA2 PARK2 PINK1 PYCR2 MIPEP VCP SACS AIFM1 CLPP XPNPEP3 MFN1 MFN2 MICOS13 PLEK UFD1L UBXN1 CLPB FLJ10842 OPA3 GDAP1L1 LONP1 C1QBP PMPCB USP9X PMPCA UBXN6 PAM16 TXN2 OXA1L PPA2 TMEM126A YME1L1 HSPD1 MICU1 SPG7 MFF TIMM50 PITRM1 MSTO1 MARCHF5 ATAD3A DNAJC19 TIMM8A TRAK1 TIMMDC1 GFER COQ5 COQ3 NPLOC4 SFXN4 RTN4IP1 OPA1 TXNRD2 STAT2 TESSADORI BICKNELL VAN HAAFTEN SYNDROME VARIANTS NUCLEOSOME ASSEMBLY%WIKIPATHWAYS_20260510%WP5573%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome variants nucleosome assembly H2BC12 H4C9 HIRA HIST1H4L CHAF1B SMIM40 RBBP4 CHAF1A NUCLEAR RECEPTORS META PATHWAY%WIKIPATHWAYS_20260510%WP2882%HOMO SAPIENS Nuclear receptors meta pathway SLC19A2 TGFB1 JUND SLC39A2 SLC39A1 SLC39A3 IL2 SP1 DNAJB1 JUN PTGR1 CYP4F12 MAFG SCD FASN MAFF SLC2A2 SLC5A1 FGF13 PCK1 SLC39A9 FTH1 SLC39A6 FGF8A SLC39A5 SLC39A8 SLC6A19 CYP2B6 SLC6A18 SLC6A17 SLC6A16 SLC6A13 HEL126 SLC5A6 SLC5A7 SLC5A8 TXN SLC5A9 CES8 EPHA3 HEL-S-10 SLC5A2 SLC6A20 SLC5A3 CCL20 SLC5A4 SLC5A5 SLC2A9 HEL-S-128m SLC6A5 SLC6A7 SERPINA1 SRXN1 SLC2A4 SLC2A6 SLC6A2 SLC2A7 SLC2A8 ME1 SLC2A14 B3GNT5 SLC2A11 SLC2A10 GCC1 ABCC5 PLK2 SLC2A13 SMARCA1 SLC2A12 CPEB4 HEL-S-25 EPB41L4B SLC39A11 ENC1 SLC39A10 EDN2 SLC39A13 TSC22D3 SLC39A12 SLC39A14 CDC42EP3 PMP2 SLC5A12 FGD4 SLC5A10 SRPX2 GPR153 SERTAD2 CAVIN2 NR1H4 KTN1 SLCO2B1 SCNN1A UGT2B4 SLC26A2 ABHD2 KAT2B IP6K3 DNAJC15 UGT2B7 ARL5B SRGN DNAJC7 NAV3 ADGRF4 PRRG4 PPP1R14C S100P NR0B2 SLC7A5 NR3C1 ALOX5AP NR1C2 AHR IL11 CCND1 MYC PDK4 SLC6A3 IFNG CCL2 ACKR3 EPHA2 ALAS1 SRC EGFR FOXO1 DNER CYP3A7 STAT3 TNS4 FGFBP1 MYOF IL1B BIRC3 AMIGO2 POLK GPAM ANGPTL4 GADD45B SLC2A3 BAX GSTM2 GSTM1 CDKN1B GSTT2 HEL-75 GCLC GSTA5 GCLM EP300 MGST1 PTPA CYP1B1 IL12B UGT1A4 HES1 IL12A UGT1A3 UGT1A7 CAP2 IGFBP1 NCOA1 NQO1 SERPINB2 UGT1A1 PTGES3 AIP ALDH3A1 CDC37 CDC2 AHRR CES3 IL17B ANKRD1 THBD CDKN1C SMC1A TNFAIP3 FTL GSTM4 ACOX1 GSTM3 GSTM5 ZIC2 EGR1 TGFBR3 HSP90AB1 CDK4 MGST3 MGST2 SLC6A8 CYP4A11 GSTA4 RGS2 GSTA3 CYP3A4 PTGS2 CYP2C19 CYP2C9 CYP1A2 MFGE8 NCOA6 HEL-S-22 SNAI2 NR1I3 SLC6A9 SLC7A11 HMOX1 SLC6A1 SLC27A1 STOM CPT1A AGER APOA2 APOC3 SLC6A11 NR1H3 NR1C1 DBI KLK15 CYP7A1 APOA5 CYP8B1 ABCG8 FABP1 ABCG5 RXRA CPT2 ABCC3 EHHADH ACADM ABCC2 UGT1A9 ABCB1 PLTP ABCB4 BAAT NRG1 POU5F1 ABCB11 SLCO1B1 SULT1A1 HBEGF SLC27A5 TGFA HGF FKBP5 BHLHB2 SQSTM1 ADH7 SPRY1 PDE4B CYP2A6 CYP1A1 KEAP1 NR1i1 TNF CES2 TGFBR2 CES1 BIRC2 GPX2 TXNRD3 GPX3 NFKB2 NFE2L2 JUNB SULT2A1 NR1i2 PPARGC1A NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20260510%WP299%HOMO SAPIENS Nuclear receptors in lipid metabolism and toxicity NR1B3 RARB ABCD2 CYP4B1 CYP2B6 CYP27B1 CYP24A1 PPARG NR1C2 CYP26A1 CYP2E1 ABCG1 NR1H3 NR1C1 NR1i1 CYP7A1 ABCA1 CYP8B1 ABCG5 CYP4A11 ABCC3 ABCC2 ABCB1 CYP3A4 ABCD3 RARA ABCB4 CYP2C9 CYP1A2 ABCB11 NR1H4 NR1i2 NR1I3 T CELL ACTIVATION SARS COV 2%WIKIPATHWAYS_20260510%WP5098%HOMO SAPIENS T cell activation SARS CoV 2 ZAP70 LTA RELA IRF2BPL BCL2L1 GRAP2 CDKN1A IL12B FOXO3A PLCG1 MAPK3 IL23R IL12A LCP2 PTEN CARD11 PIK3CD CD3G BCL10 ICOS RPTOR CD3E DEPTOR CD3D CCND1 HLA-DRA IL2 STAT4 MLST8 TYK2 IL12RB1 HRAS MAP2K2 IFNG IL23A TSC2 LCK TSC1 PTPRC MYD88 SOS1 NFATC1 IL4 PDPK1 JUN LAT IL17A HLA-DRB1 CTLA4 FYN MTOR RHEB CDKN2A GRB2 IKBKB CCL19 NFKBIA CHUK PPP3CC MAPK1 IKBKG RAF1 CCL28 NFKB1 IFNAR2 TNF PIK3R1 IFNAR1 IFNB1 RICTOR GSK3B BAX CD80 IL18R1 MAP2K1 FOS PRKCQ PI3K AKT MTOR VITAMIN D3 SIGNALING%WIKIPATHWAYS_20260510%WP4141%HOMO SAPIENS PI3K AKT mTOR vitamin D3 signaling TSC2 TSC1 MTOR PRKAA2 RXRA RELA HK3 SLC2A3 CYP24A1 IL10 GSK3B PIK3CA IL12A PFKFB4 CD80 HLA-DRA PDHA1 HEL-S-133P MYC NR1i1 ENDOMETRIAL CANCER%WIKIPATHWAYS_20260510%WP4155%HOMO SAPIENS Endometrial cancer CDKN1A FOXO3A MAPK3 PTEN HEL-S-28 PIK3CD BRAF CCND1 MYC AKT3 HRAS FGF2 MAP2K2 CTNNB1 AXIN2 SOS1 SOS2 PDPK1 PIK3CA TCF7L2 LEF1 AXIN1 EGFR EGF TCF7L1 APC KRAS GRB2 APC2 FGFR3 FGFR2 FGFR1 ARAF MAPK1 RAF1 POLK DDB2 PIK3R3 CTNNA1 PIK3R2 PIK3R1 CTNNA3 NRAS CTNNA2 BAK1 GADD45B BAD GADD45A GADD45G GSK3B BAX CASP9 MAP2K1 FOS ERBB2 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES INTERFERON INDUCTION%WIKIPATHWAYS_20260510%WP4880%HOMO SAPIENS Host pathogen interaction of human coronaviruses interferon induction IRF9 IKBKE TICAM1 IRF3 TLR7 RIGI MAPK8 JAK1 IKBKB NFKBIA STAT1 CHUK TRAF6 MAPK14 IKBKG NFKB1 TYK2 IFNAR2 MAVS TRAF3 IFNAR1 MYD88 RIPK1 STAT2 JUN MAP3K7 EIF2AK2 OAS1 OAS2 IFIH1 FOS TBK1 CELIAC DISEASE MECHANISM AND THERAPIES%WIKIPATHWAYS_20260510%WP5562%HOMO SAPIENS Celiac disease mechanism and therapies ITGA4 DHODH IFNG IL15 TNF EGFR IL2 IL-21 F2RL1 ITGB7 TARGETING YAP IN PANCREATIC DUCTAL ADENOCARCINOMA PDAC %WIKIPATHWAYS_20260510%WP5495%HOMO SAPIENS Targeting YAP in pancreatic ductal adenocarcinoma PDAC YAP1 CYR61 PRKAA2 CTGF PRKAG1 PRKAG2 RHOD PRKAA1 PRKAG3 MOB1A TEAD2 TEAD3 TEAD4 RHO HMGCR PRKAB2 LATS1 PRKAB1 LATS2 STK4 RHOB ARHA NEURAL CREST DIFFERENTIATION%WIKIPATHWAYS_20260510%WP2064%HOMO SAPIENS Neural crest differentiation HES5 OLIG2 SOX10 FOXD3 NEUROG1 DMBX1 OLIG1 MPZ MIA OLIG3 ISL1 HOXB1 HDAC3 HDAC9 DLL3 HES1 HAND1 DLX5 DLL4 TFAP2A HDAC11 PRTG PMP22 GJB1 LHX5 PAX3 PAX7 MYC ASCL1 GBX2 FGF2 HDAC5 TLX2 CTNNB1 HDAC6 MSX1 FGF8 TCF4 AXIN2 SMAD1 TBX6 DVL1 DVL2 DVL3 HDAC2 AXIN1 HDAC1 GFAP ZIC5 DCT CTBP2 RBPJ WNT1 HEY2 LHX1 CDH2 TFAP2B ITGB1 TCF7L1 FGF8A NOTCH3 ID1 WNT8A HDAC7 FGFR3 BMP4 FGFR2 PHOX2B FGFR1 SNAI1 FZD3 WNT3A NFKB1 RHOB BMP7 MBP CDH6 ZIC1 HOXA1 HDAC8 NOTCH2 SOX9 NOTCH1 GSK3B SOX5 COL11A2 COL2A1 NFKB2 HDAC10 TWIST1 MSX2 MYB SNAI2 ID SIGNALING%WIKIPATHWAYS_20260510%WP53%HOMO SAPIENS ID signaling CDK2 ID3 PAX2 RBL2 RBL1 ID1 MYOD1 ELK3 CCNE1 ID2 RB1 PAX5 PAX8 16P12 2 COPY NUMBER VARIATION SYNDROME 520KB %WIKIPATHWAYS_20260510%WP5510%HOMO SAPIENS 16p12 2 copy number variation syndrome 520kb MAPK12 PRKAA2 MAPK11 NDUFS8 MAPK3 NDUFS3 POLR3E RPTOR RAB5IF RPS6KB1 MOSMO TRPM7 MAPK14 PDZD9 SDR42E2 VWA3A MLST8 CDC2 MAP2K2 CDK2 CALM1 NDUFA9 UQCRB MTOR UQCR11 UQCR10 CYB UQCRH EEF2 UQCRQ UQCRC1 UQCRFS1 CYC1 UQCRC2 CDR2 PRKAB2 PRKAB1 MAPK1 MAPK13 RPS6KA1 PRKAG1 COX7C PRKAG2 EEF2K COX5A PRKAG3 PRKAA1 COXFA4 MAP2K1 CDH18 CHROMOSOMAL AND MICROSATELLITE INSTABILITY IN COLORECTAL CANCER %WIKIPATHWAYS_20260510%WP4216%HOMO SAPIENS Chromosomal and microsatellite instability in colorectal cancer BBC3 CSNK1A1L BCL2L11 EXOC2 MAPK9 MAPK8 CDKN1A MAPK3 TGFB1 BRAF CCND1 SMAD2 MYC SMAD4 AKT3 CYCS ARHA TGFBR1 BCL2 CTNNB1 AXIN2 JUN TCF7L2 LEF1 AXIN1 APPL1 TBK1 CSNK1A1 NTN1 MAPK10 TCF7L1 APC MSH2 MSH3 REL KRAS MSH6 RAC3 APC2 BIRC5 ARAF MAPK1 RAC1 RAF1 POLK DDB2 TGFBR2 BAK1 GADD45B PTGS2 BAD PMAIP1 GADD45A GADD45G GSK3B BAX CASP9 CASP3 DCC MAP2K1 RALA FOS RALB CYSTEINE AND METHIONINE CATABOLISM%WIKIPATHWAYS_20260510%WP4504%HOMO SAPIENS Cysteine and methionine catabolism pcap HEL-S-64p CBS MAT1A SQOR MTR CDO1 GCLC CTH ETHE1 SUOX HEL-S-61p THYMIC STROMAL LYMPHOPOIETIN TSLP SIGNALING%WIKIPATHWAYS_20260510%WP2203%HOMO SAPIENS Thymic stromal lymphopoietin TSLP signaling STAT3 FYN YES1 GAB2 RELA TEC MAPK9 MAPK8 MAPK3 JAK1 LYN STAT5B NFKBIA STAT1 RPS6 CRLF2 MAPK1 MAPK14 BTK TSLP STAT4 NFKB1 MAP2K2 LCK RELB PTPN11 NFKB2 SRC IL7R MAP2K1 EIF4EBP1 FES MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20260510%WP289%HOMO SAPIENS Myometrial relaxation and contraction pathways CREB1 CRH CRHR1 PLCG2 ADM PLCG1 IGFBP1 IGFBP5 SP1 ACTG1 HEL-S-14 JUN MAFF ATF2 ETS2 PS1TP5BP1 NFKB1 HEL2 OXTR OXT SLC8A1 RGS4 RGS5 RGS2 GJA1 RGS1 RGS6 RGS7 PRKCH CALCA PRKCB PRKCE PRKCA CACNB3 ADCY9 PRKAR1B PRKAR1A PRKCQ PRKD1 ITPR2 PRKCZ GRK5 GRK4 SFN RLN1 GNG12 GNG11 GNG13 PKIB PKIA GNB2 GNB1 CRCP GABPB1 GNAS RXFP2 GNB4 IGFBP4 GNB3 CNN2 GNB5 CALD1 PKIG DGKZ IGFBP6 CALM1 RYR1 RAMP2 RYR2 RAMP3 ATP2A2 CORIN GUCA2B ARRB2 GUCA2A ACKR5 RYR3 GNGT1 YWHAQ HEL-S-1 YWHAG ACKR3 YWHAZ RAMP1 PLCB3 RGS18 RGS17 CAMK2D RGS14 RGS16 CAMK2A MYL2 ADCY3 ADCY1 ADCY8 ADCY6 ATF3 GNG3 GNG2 GNG5 GNG4 GNG7 RGS20 ATF5 GNG8 CAMK2G GABPA HEL-S-21 ATF1 ATF6B IL1B PDE4B CREB3 RGS10 RGS11 PDE4D MYLK2 ATF4 IL6 IGFBP2 LPAR1 ACTA1 ACTA2 MYL4 FOS ACRYLAMIDE BIOTRANSFORMATION AND EXPOSURE BIOMARKERS%WIKIPATHWAYS_20260510%WP4233%HOMO SAPIENS Acrylamide biotransformation and exposure biomarkers CYP2E1 PERTURBATIONS TO HOST CELL AUTOPHAGY INDUCED BY SARS COV 2 PROTEINS%WIKIPATHWAYS_20260510%WP4936%HOMO SAPIENS Perturbations to host cell autophagy induced by SARS CoV 2 proteins CALCOCO2 EIF4B VPS41 MTOR PRKAA2 RHEB ATG9A SQSTM1 ULK1 LAMP2 RPS6 DKFZp762B153 OPTN RPTOR RPS6KB1 DEPTOR HEL-S-30 VPS39 MLST8 ATG5 ATG3 TMEM59 NBR1 ATG12 PPP1R9A VAMP8 ATG16L1 AKT1S1 LARP1 VPS18 GABARAPL2 VPS33A RB1CC1 VPS11 RAB7A LAMTOR1 VPS16 APOB ATG2B TESSADORI BICKNELL VAN HAAFTEN SYNDROME 3 OVERVIEW PATHWAY%WIKIPATHWAYS_20260510%WP5575%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome 3 overview pathway TBP H4C9 MED23 TAF13 TAF8 MED27 LUPUS THERAPIES%WIKIPATHWAYS_20260510%WP5560%HOMO SAPIENS Lupus therapies TNLG7A C4B_2 C2 IL12B IL12A CD40LG HEL-S-62p C4A C1QC IL6R IL17B IFNG IL23A IL25 CD19 IL6 MS4A1 CD40 C1QA IL17F IL17D IL17C IL17A CD80 C1QB CD22 TP53 NETWORK%WIKIPATHWAYS_20260510%WP1742%HOMO SAPIENS TP53 network BCL2 OTX2 BBC3 TNFSF10 CDKN2A MDM2 TP63 BOK GADD45A PMAIP1 CDKN1A TP73 BAX ATM SUMO1 MYC SPINA BIFIDA%WIKIPATHWAYS_20260510%WP5150%HOMO SAPIENS Spina bifida MAT1A MTR MTHFD1 DNMT3B AHCYL2 MTRR SHMT1 AMINO ACID METABOLISM%WIKIPATHWAYS_20260510%WP3925%HOMO SAPIENS Amino acid metabolism TDO2 GLS ALDH7A1 LARS2 GLUD1 ACO2 TPO DLD DBH G6PC2 PDK4 DDC TH MAOA EHHADH ACADM PDHX SUCLG1 BCAT1 PIG59 PPM1L HEL-S-61p ADH5 P4HA2 IARS FARSB FTCD ARG2 FH PDHA1 HEL-S-32 SDHA HEL-S-26 CS ACLY PC PNMT OGDH CBS PCK1 EPRS1 HAL GPT2 CAD HDC ADH1C ADH7 OTC HEL-S-30 HEL-S-53e HEL-S-133P ARG1 HEL-S-4 ASS1 SRM SMS ASNS ALDH18A1 MDH2 GOT2 ACSS1 RARS1 MARS2 HEL-S-64p MCCC1 HEL-75 CTH GCLM HMGCL TPH1 TRYPTOPHAN KYNURENINE PATHWAY IN POST COVID SYNDROME%WIKIPATHWAYS_20260510%WP5549%HOMO SAPIENS Tryptophan kynurenine pathway in post COVID syndrome IFNG DDC AADAT TNF HAAO GOT2 IDO1 IL6 TDO2 AFMID KYAT3 KYNU KYAT1 KMO IDO2 IFNB1 IL1B AHR IFNA6 PKC GAMMA CALCIUM SIGNALING IN ATAXIA%WIKIPATHWAYS_20260510%WP4760%HOMO SAPIENS PKC gamma calcium signaling in ataxia CACNA1A GNA14 PLCB4 GNA15 TRPC3 RYR3 GNA11 GRIA3 GRIA2 PLCB1 PLCB3 CA8 ATP2B2 HOMER3 PLCB2 GRIA4 NANOMATERIAL INDUCED APOPTOSIS%WIKIPATHWAYS_20260510%WP2507%HOMO SAPIENS Nanomaterial induced apoptosis DIABLO BCL2 APAF1 HTRA2 CASP8 CASP6 TNFSF6 FADD BAK1 BAX CASP9 AIFM1 CASP3 PRF1 FAS CYCS BLOOD CLOTTING CASCADE%WIKIPATHWAYS_20260510%WP272%HOMO SAPIENS Blood clotting cascade PLG VWF SERPINF2 F3 HEL-S-78p F9 F5 F10 F8 F11 F13B PLAT KLNA1 F2 KLKB1 SERPINB2 FGA F7 16P11 2 DISTAL DELETION SYNDROME%WIKIPATHWAYS_20260510%WP4950%HOMO SAPIENS 16p11 2 distal deletion syndrome INSR NFATC2 RABEP2 PLN ATP2A1 GRB2 SDCCAG8 VAV2 TRAF1 RAB5A IFITM1 SH2B1 MPL HEL-S-62p RAB4A CD82 KDR TRAF2 CD19 PRMT1 CR2 IL4 SLN NFATC2IP LAT TUFM ATXN2L SPNS1 CD81 OVERVIEW OF PROINFLAMMATORY AND PROFIBROTIC MEDIATORS%WIKIPATHWAYS_20260510%WP5095%HOMO SAPIENS Overview of proinflammatory and profibrotic mediators IL1RN CSF2 CSF1 CXCL13 IL36A IL9 IL36B CCL23 IL12B IL1A IL12A TGFB1 IL24 IL2 IL36RN IL17B IL37 IL36G IL1F10 IL25 IL17D IL17C IFNA1 CXCL14 IF1AA9 CXCL16 IFNA13 CSF3 IFNA14 IFNA16 IL7 CCL4L2 IFNA17 IFNA10 XCL1 CCL11 IFNA21 CCL1 CCL19 CXCL6 CCL17 CXCL9 CCL15 CCL25 CCL24 CXCL17 CCL22 CXCL1 CCL21 CXCL3 CCL20 CXCL2 IL33 TSLP CXCL5 CCL28 NFKB1 IFNA4 CCL26 IFNA7 CX3CL1 IFNA6 IFNA2 IFNA8 CCL14 CCL13 CCL3L3 OSM SPP1 CCL27 IFNB1 PPBP CCL18 PF4 CCL16 CNTF EBI3 MMP3 LTA IL13 IL10 IF2B1 IL15 IL27 IL11 IF2G IL-21 CCL8 CCL7 CCL5 EPO CCL4 CCL3 TNFSF13 IFNG CCL2 IL23A IL3 CXCL11 CXCL12 AREG LIF IL4 IL17F IL17A IF2D IFNW1 IF1IB1 PF4V1 IL19 XCL2 IFNL2 IFNL3 IL31 TNLG7A IL1B CTF1 IL18 MMP9 TNF IL6 IFNK CXCL8 VEGFA IL5 LEUKOCYTE INTRINSIC HIPPO PATHWAY FUNCTIONS%WIKIPATHWAYS_20260510%WP4542%HOMO SAPIENS Leukocyte intrinsic Hippo pathway functions KNSTRN YAP1 RAB13 FERMT3 FYB1 CCR7 STK38L PRDM1 TEAD2 TEAD3 FOXO3A FOXO4 MAPK14 RAC1 ARHA FOXP3 WWTR1 CD19 LPL YWHAQ MOB1A TEAD4 RAP1A LATS1 FOXO1 LATS2 FOXO6 ALANINE AND ASPARTATE METABOLISM%WIKIPATHWAYS_20260510%WP106%HOMO SAPIENS Alanine and aspartate metabolism PC ASL ASPA GOT2 AGXT GAD1 GPT GAD2 ASS1 ABAT ENDOPLASMIC RETICULUM STRESS RESPONSE IN CORONAVIRUS INFECTION%WIKIPATHWAYS_20260510%WP4861%HOMO SAPIENS Endoplasmic reticulum stress response in coronavirus infection PPP1R15A PPP1R15B PPP1R13B PPP1R11 PPP1R14C PPP1R2 PPP1R8 PPP1R16B PPP1R14A PPP1R14B MAPK8 PPP1R16A EIF2S1 PPP1R3G HEL-S-80p PPP1R3F PPP1R3E PPP1R1C PPP1R3D PPP1R14D HEL-S-89n PPP1R10 MAP1LC3A ATF4 PPP1R7 BCL2 PPP1R1B PPP1R1A PPP1R9A MBTPS1 PPP1R12B PPP1R12C PPP1R3A MBTPS2 PPP1R3C PPP1R3B DDIT3 EIF2AK2 XBP1 EIF2AK1 PPP1CC ERN1 PENTOSE PHOSPHATE PATHWAY IN SENESCENT CELLS%WIKIPATHWAYS_20260510%WP5043%HOMO SAPIENS Pentose phosphate pathway in senescent cells RPIA HEL-S-304 PRPS1L1 DERA RPE WNT SIGNALING IN KIDNEY DISEASE%WIKIPATHWAYS_20260510%WP4150%HOMO SAPIENS Wnt signaling in kidney disease MAPK10 WNT2B WNT5B WNT9B MAPK9 FZD1 WNT16 MAPK8 NPHP3 WNT3 INVS WNT10B WNT10A FZD3 FZD2 FZD5 FZD4 WNT3A WNT7B FZD7 FZD9 ARHA WNT7A FZD8 CTNNB1 DVL1 DVL2 DVL3 WNT4 LRP5 LRP6 WNT1 COCAINE METABOLISM%WIKIPATHWAYS_20260510%WP2826%HOMO SAPIENS Cocaine metabolism BCHE CES2 CES1 CYP3A4 LEPTIN AND ADIPONECTIN%WIKIPATHWAYS_20260510%WP3934%HOMO SAPIENS Leptin and adiponectin ADIPOR2 PRKAG1 PRKAB1 ADIPOR1 ACACA CPT1A PRKAA1 LEPR LEP LUPUS PATHOGENESIS%WIKIPATHWAYS_20260510%WP5559%HOMO SAPIENS Lupus pathogenesis TLR4 TNLG7A IL6 TLR7 PDCD1 CD40 ICOS IL17A CD40LG CD80 TNFRSF13C BCR ICOSLG IFNA2 TLR9 NON HOMOLOGOUS END JOINING%WIKIPATHWAYS_20260510%WP438%HOMO SAPIENS Non homologous end joining POLL WRN NHEJ1 POLM PRKDC XRCC5 EGFR TYROSINE KINASE INHIBITOR RESISTANCE%WIKIPATHWAYS_20260510%WP4806%HOMO SAPIENS EGFR tyrosine kinase inhibitor resistance BCL2L11 BCL2L1 PLCG2 FOXO3A PLCG1 JAK1 MAPK3 PTEN PIK3CD IGF1R RPS6 RPS6KB1 BRAF RPS6KB2 CCND1 MYC AXL AKT3 KDR HRAS FGF2 IL6R PDGFRA MAP2K2 BCL2 SOS1 SOS2 MET PDPK1 NRG1 PIK3CA NRG2 SHC1 SRC EGFR SHC4 SHC3 TGFA ERBB3 IGF1 EIF4EBP1 EGF STAT3 MTOR PDGFD HGF PDGFC PDGFA KRAS GRB2 FGFR3 FGFR2 RRAS2 ARAF RRAS MAPK1 RAF1 SHC2 PIK3R3 PIK3R2 PIK3R1 NRAS IL6 BAD GSK3B NF1 EIF4E BAX VEGFA PRKCB PRKCA MAP2K1 ERBB2 ROTENONE METABOLISM%WIKIPATHWAYS_20260510%WP5486%HOMO SAPIENS Rotenone metabolism CYP3A4 CYP2C19 OMEGA 6 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260510%WP5424%HOMO SAPIENS Omega 6 fatty acids in senescence MAPK11 PTGIS PRXL2B DECR1 CDKN1A ALOX5AP PTGES DPEP2 HEL-S-53e PTGES3 CYP4F8 ALOX12 ALOX15 SIRT1 HEL-S-298 HPGD PTGS2 GPX1 PTGS1 ELOVL5 LTC4S ELOVL2 SLCO2A1 ALOXE3 ALOX15B FADS2 ALOX5 EPHX2 RB1 FADS1 NAT2 HEL-S-22 AKR1B1 NETWORK MAP OF SARS COV 2 SIGNALING%WIKIPATHWAYS_20260510%WP5115%HOMO SAPIENS Network map of SARS CoV 2 signaling TRPM2 PARP2 CXCL13 INTS4 IL9 MAPK8 IL1A CARD11 CASP5 FGF2 ACTG1 LBP HBB HBD JUN CD14 CXCL16 IL7 CCR6 PS1TP5BP1 CCL11 PMPCB CCL1 CCL15 CCL22 CCL21 CCL20 CCL26 PITRM1 GABARAPL2 CCL27 STEAP3 IGLL1 PIAS1 MIB1 ADAM9 IL10 IF2B1 CCR5 CD3G ULK1 TPO DKFZp762B153 RPTOR AHR CD3E DEPTOR HLA-DRA IL-21 LGALS3BP CCL8 MLST8 CCL5 CCL4 CCL3 IFNG CCL2 LCK MMP25 HIF1A CXCL12 AKT1S1 MYD88 IL4 IL17A NTRK1 OAS2 CD8B1 IRF9 CD8A FYN MTOR PTPN6 MOV10 FAM83A RHEB CXCR1 BIRC5 C1QBP IL1B HEL117 GTSE1 VPS36 RAC1 WDR74 APOD HEL103 PRG3 HRG CTSZ SERPINA10 SDF2 GP1BA IL16 TLE3 HMFT1766 OS9 APOL1 RTN4 COQ8B SRP19 NRF HP CLCC1 GTF2F2 TBKBP1 IFI6 UGCGL2 G3BP2 NPTX1 MDN1 NEK9 TRO TRIM59 ITIH3 ATE1 CD2 ATP13A3 FAM98A IL5 TNFSF10 EIF4A2 IL12A CD226 CCNB2 CCNB1 ITIH4 CDC2 SRP54 SMAD1 DKFZp781O1323 NFATC3 HLA-DRB1 IRAK1 HEL-S-81p EGR1 CXCL6 CXCL9 IFITM1 RRAS TRAF6 CXCL1 IKBKG CXCL3 IL33 CXCL2 RRM2 CXCL5 C8A TRAF2 CEBPB IL8RB LARP1 PTGS2 IFNB1 MX1 TP53I3 SIGMAR1 PF4 IL18RAP IL1R2 IFITM3 C1S PRKCQ CFH ZAP70 C1R CFI CASP8 CFP IL13 JAK1 CRP STAT1 RPS6 IFI27 APOA2 TF VPS18 VPS33A VPS11 APOH VPS16 HLA-DRB5 ITCH SELP BST2 FGA IFIH1 EIF4EBP1 APOC1 TBK1 CTSL CD163 IRF3 VPS41 HEL-S-78p ALB SAA1 SAA2 RIGI IFI44L CPN1 GGH IFIT1 CAMK4 TOMM70 HEL-S-72p IL18 NLRP1 TNF ACE2 TGFBR2 DDIT4 MAVS IL6 TRAF3 NLRP3 HEL-S-130P CXCL8 EIF4E NFKB2 CASP9 CASP3 JUNB FOS HEMESYNTHESIS DEFECTS AND PORPHYRIAS%WIKIPATHWAYS_20260510%WP5169%HOMO SAPIENS Hemesynthesis defects and porphyrias ALAS2 ALAS1 FECH HMBS UROD UROS CPOX PDGFR BETA PATHWAY%WIKIPATHWAYS_20260510%WP3972%HOMO SAPIENS PDGFR beta pathway STAT3 PIK3R1 GRB2 MAPK8 SOS1 MAP2K4 PLCG1 JUN MAPK3 JAK1 PIK3CA STAT5B SHC1 PRKCB MAP3K1 STAT1 PRKCA RAF1 MAP2K1 EIF2AK2 FOS HRAS GASTRIC CANCER NETWORK 1%WIKIPATHWAYS_20260510%WP2361%HOMO SAPIENS Gastric cancer network 1 ESM1 TOP2A AURKA MYBL2 RUVBL1 ECT2 KIF20B E2F7 NUP107 H3F3B APC S100P ACTL6A NOTCH1 UBE2C CEP192 LIN9 H4C9 INO80D HCTP4 GATD3 KIF15 SMOC2 CENPF GPCRS CLASS B SECRETIN LIKE%WIKIPATHWAYS_20260510%WP334%HOMO SAPIENS GPCRs class B secretin like PTH1R GIPR GCGR SCTR VIPR2 GPR64 CRHR1 PTH2R CRHR2 GHRHR ADGRE2 ADCYAP1R1 CALCR ADGRL4 ADGRL2 ADGRL3 CALCRL ADGRE5 ADGRL1 GLP1R PLURIPOTENT STEM CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260510%WP2848%HOMO SAPIENS Pluripotent stem cell differentiation pathway EGF CSF1 WNT2B NODAL FGF10 HGF PDGFA SHH CXCR1 INHBA GDF5 BMP4 TGFB1 FLT3LG TPO FGF7A NTF4 IL11 WNT3A WNT7B NT5E EPO FGF2 IL6R LEFTY1 KITLG TF FGF8 TNFSF11 IL3 IL6 NOG DKK1 KIT NOTCH1 FST CSF1R VEGFA ALK CNTF WNT1 INS IGF1 SPHINGOLIPID PATHWAY%WIKIPATHWAYS_20260510%WP1422%HOMO SAPIENS Sphingolipid pathway CERK PPP2CA PLPP1 SGMS1 SPHK1 SGMS2 UGT8 UGCG KDSR GBA2 CERS2 ASAH2 ACER1 SPTLC3 SERINC1 CERT1 SPHK2 SGPP2 SGPL1 SPTLC2 SPTLC1 CERS3 CERS5 CERS6 TRANSCRIPTION CO FACTORS SKI AND SKIL PROTEIN PARTNERS%WIKIPATHWAYS_20260510%WP4533%HOMO SAPIENS Transcription co factors SKI and SKIL protein partners HDAC3 SKI HDAC1 LATS1 SIN3A LATS2 MERTK TEAD2 SKIL TEAD3 TEAD4 NF1 DRAVET SYNDROME%WIKIPATHWAYS_20260510%WP5200%HOMO SAPIENS Dravet syndrome FGF13 PRR5 MTOR MAPK11 SCN3B CHD2 SNTA1 KCNA2 PCDH19 SCN3A SCN1A SCN2B STXBP1 NFKB1 SCN8A MLST8 SCN2A SCN1B SCN4B CALM1 TNF MAPKAP1 RICTOR PIK3CA PRKCA CAMK2A HCN1 INDUCTION OF AUTOPHAGY AND TOLL LIKE RECEPTOR SIGNALING BY GRAPHENE OXIDE %WIKIPATHWAYS_20260510%WP5336%HOMO SAPIENS Induction of autophagy and toll like receptor signaling by graphene oxide IFNG TNF IRF3 TLR4 TRAF6 MYD88 NFKB1 MAP1LC3A IFNB1 TLR9 MAMMARY GLAND DEVELOPMENT PUBERTY STAGE 2 OF 4%WIKIPATHWAYS_20260510%WP2814%HOMO SAPIENS Mammary gland development puberty stage 2 of 4 TIMP1 EGF CCND1 HEL113 PGR MYC AREG FOSL1 ERBB2 SARS CORONAVIRUS AND INNATE IMMUNITY%WIKIPATHWAYS_20260510%WP4912%HOMO SAPIENS SARS coronavirus and innate immunity IRF9 IKBKE IFNA13 TICAM1 IFNA14 IRF3 IFNA16 IFNA17 TLR3 RIGI IFNA10 IFNA21 JAK1 STAT1 IFNA4 IFNA7 TYK2 IFNA6 IFNA2 IFNA8 IFNAR2 ACE2 MAVS TRAF3 IFNAR1 IFNB1 STAT2 IFNA1 IF1AA9 IFIH1 TBK1 COMPLEMENT MEDIATED INFLAMMATION OF PULMONARY ALVEOLUS IN COVID 19 HYPOTHETICAL PATHWAY %WIKIPATHWAYS_20260510%WP5148%HOMO SAPIENS Complement mediated inflammation of pulmonary alveolus in COVID 19 hypothetical pathway C9 MASP2 C3AR1 FCN1 ACE2 C5AR1 HEL-S-62p COLEC11 C8A C6 C7 GLP 1 FROM INTESTINE AND PANCREAS AND ROLE IN GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260510%WP5452%HOMO SAPIENS GLP 1 from intestine and pancreas and role in glucose homeostasis GCG PCSK2 INS GLP1R PCSK1 MIRNA TARGETS IN ECM AND MEMBRANE RECEPTORS%WIKIPATHWAYS_20260510%WP2911%HOMO SAPIENS miRNA targets in ECM and membrane receptors LAMA4 XB SDC2 LAMB2 COL5A3 COL5A2 ITGB6 COL4A1 COL1A2 COL4A2 ITGA1 COL3A1 THBS2 THBS1 LAMC1 ITGB5 COL6A1 NETRIN UNC5B SIGNALING%WIKIPATHWAYS_20260510%WP4747%HOMO SAPIENS Netrin UNC5B signaling YAP1 INPP5D NTN1 FYN PTPA ROBO4 IL10 IL1A ALPL MAPK3 PTK2B MYF5 PPP2R1B MAPK1 MAPK14 DCSTAMP RAC1 RAF1 KDR RLF ARHA NTN3 SELE PLEKHH1 UNC5B CCL2 MAP2K2 CIP2A TNF VCAM1 CTGF NEO1 AGAP2 PTPN11 JUN COL1A1 PIK3CA ITGB4 SRC PRKCA CASP3 ARHGEF12 MAP2K1 RGMA MECP2 AND ASSOCIATED RETT SYNDROME%WIKIPATHWAYS_20260510%WP3584%HOMO SAPIENS MECP2 and associated Rett syndrome NCOR1 CREB1 TET2 REST FUS BCL6 DLX5 PTEN IGF1R RPS6 GAD1 IGF2 YBX1 FGF2 SP1 PSIP1 RBFOX1 TET3 DLX6 TET1 NREP FUT8 PRPF38A HNRNPH1 POU4F1 HNRNPF TAF1 FOXG1 SST HDAC1 CAMK2A IGF1 APOC2 MEF2C CNP MTOR SIN3A GRIA3 FKBP5 POU3F2 GPRIN1 CDON EZH2 CTCF FGF7A MBP CEBPD MYT1 BDNF HEL-S-20 SGK1 FGF5C OPRK1 NF1 TAP1 UBE3A SMC3 GRIN1 SP3 GRIA4 TARDBP FIBRIN COMPLEMENT RECEPTOR 3 SIGNALING%WIKIPATHWAYS_20260510%WP4136%HOMO SAPIENS Fibrin complement receptor 3 signaling PLG TICAM1 IRF3 TLR4 HEL-S-78p RELA TLR3 REL NOS2 IL12B PLAT IKBKB SYK FCER1G CHUK ITGAM TYROBP TRAF6 CXCL3 IKBKG IRAK4 NFKB1 ARHA LY96 CCL2 TNF IL6 LBP MYD88 TIRAP IFNB1 PIK3CA SRC CD14 TICAM2 IRAK2 IRAK1 FGA INTERFERON MEDIATED SIGNALING%WIKIPATHWAYS_20260510%WP4558%HOMO SAPIENS Interferon mediated signaling IRF9 IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 IFNA21 JAK1 STAT1 IFNA4 IFNGR1 IFNA7 IL10RB TYK2 IFNA6 IFNA2 IFNLR1 IFNA8 IFNAR2 IFNG PIK3R1 IFNAR1 IFNE IFNK IFNL4 IFNB1 STAT2 PIK3CA PRKCA IFNA1 IFNGR2 IFNW1 IF1IB1 IF1AA9 IFNL2 IFNL3 TRANSCRIPTIONAL REGULATION OF MEMORY B CELL DIFFERENTIATION%WIKIPATHWAYS_20260510%WP5491%HOMO SAPIENS Transcriptional regulation of memory B cell differentiation STAT3 TLR4 TLR7 BCL6 TLR3 CDKN2A CD79B BCL2L1 TCF3 CDKN1A SPI1 LYN EZH2 SYK TNFRSF13C POU2F2 MYC NFKB1 TLR10 CD79A ID3 IRF4 TCF4 IL6 IL21R CD40 SPIB POU2AF1 CCND3 CDKN1B TLR8 TLR5 ICOSLG BCR TLR1 CCND2 MEF2C IRF8 MEF2B TLR9 NICOTINE METABOLISM IN LIVER CELLS%WIKIPATHWAYS_20260510%WP1600%HOMO SAPIENS Nicotine metabolism in liver cells AOX1 CYP2A6 UGT1A9 CYP2B6 UGT1A4 MODULATION OF PI3K AKT MTOR SIGNALING BY BIOACTIVE SPHINGOLIPIDS%WIKIPATHWAYS_20260510%WP5192%HOMO SAPIENS Modulation of PI3K Akt mTOR signaling by bioactive sphingolipids ASAH2 PIK3CA CERK TSC1 MTOR IGF1R S1PR1 SPHK2 S1PR3 HIF1A CERS1 NFKB1 FANCONI ANEMIA%WIKIPATHWAYS_20260510%WP5465%HOMO SAPIENS Fanconi anemia FANCB MRE11A FANCE NBN FANCF BRCA2 RAD51C FAAP24 BRCA1 CENPX CENPS SMARCA4 PTEN ERCC1 HEL-S-125m SLX4 UBE2T FANCG FAN1 CEBPD RFWD3 FANCD2 ATR BRIP1 FANCM FANCL USP1 FANCA FANCC DCLRE1B CTDP1 PALB2 UHRF2 MCM2 MEN1 ATM EGFR MAD2L2 RAD50 UHRF1 REV1 RAD51 GPCRS OTHER%WIKIPATHWAYS_20260510%WP117%HOMO SAPIENS GPCRs other EDNRA C5AR2 HTR2A GPR83 HTR1F ADRB2 GHRHR ADGRE2 ADGRL2 ADGRL3 CCR5 CNR1 HTR7 CXCR3 ADRA1D DRD4 F2R GPR183 OR1G1 OR2M4 GPR61 GPR143 GPR62 CELSR1 GRPR CELSR3 RXFP3 GPR176 GPR132 GNRHR GPR135 ADGRV1 ALG6 OR1F1 OR2H1 TAAR5 OR1J2 TAAR2 OR1N1 GPR162 CXCR1 CCR2 OR5AC2 CCKBR FSHR ADGRF5 VN1R1 SSTR2 OR10A2 OR6C3 OR3A3 SMO OR6C2 OR10A5 OR3A1 OR8G1 OR1E1 GPR88 GPR84 MCHR2 FY OR2B6 NTSR1 OR5D3 P2RY13 GPR17 P2RY11 CHRM2 OR2F1 CHRM3 GPR55 EMR3 ADGRD1 OR2A5 LGR6 OR2A4 GPR18 OR7E24 IL8RB DRD3 UTS2R PTGFR ADORA2A S1PR1 CELSR2 CYTOKINE CYTOKINE RECEPTOR INTERACTION%WIKIPATHWAYS_20260510%WP5473%HOMO SAPIENS Cytokine cytokine receptor interaction IL1RN CSF2 CSF1 CXCL13 IL2RG IL36A GDF8 IL9 IL36B IL9R IL1R1 CCL23 IL1A TGFB1 IL24 CD40LG ACVRL1 IL2 TNLG1B IL1RL2 IL36RN IL37 IL36G TNFRSF10B IL1F10 IL25 IL17D IL17C CXCL14 CXCL16 CCR10 CCR1 XCR1 CSF3 IL7 CCR8 CCL4L2 CCR7 CCR6 CCR4 CCR2 XCL1 CCL11 CXCR5 CXCR6 CCL1 CCL19 CCL15 CCL25 TNFRSF14 CCL24 CCL22 CCL21 CCL20 CCL28 PRLR CCL26 GH1 BMP3 CCL14 CCL13 GDF10 IL13RA1 CCL27 CCL18 PRL NODAL IL10 IL15RA IF2B1 IL23R IL15 CCR5 IL27 TPO IL11 IF2G CXCR4 IL-21 IL27RA CCL8 IFNGR1 CCL7 CCL5 IL6R TGFBR1 CCL4 CCL3 INHBB IFNG CCL2 IL23A TWEAK TNFRSF12A IL3 ACVR2A CXCL11 CXCL12 IL2RB IL21R ACKR3 IL4 CSF1R IL2RA IL17F IL17A IF2D IFNW1 IF1IB1 PF4V1 XCL2 TACI IFNL2 NGFR IFNL3 IL31 CXCR1 ANP32B TNFRSF13C TNLG5A TNFRSF25 TNFRSF21 IFNK IFNGR2 IL5 LEPR TNFSF10 AMHR2 GDF5 TNFRSF9 ACVR1B CNTFR MPL GHR IL11RA IL20RA IL20RB IL10RB IL10RA IFNLR1 IL17B IL22RA1 INHA IL17RC BMP6 GDF9 TNFRSF1B BMPR1A BMPR2 BMP15 GDF15 AMH CCR3 ACVR1 CSF3R ACVR2B CXCL6 CXCL9 CXCL17 CXCL1 CXCL3 IL33 CXCL2 TSLP CXCL5 TNFRSF10C CX3CL1 IFNA2 IFNAR2 BMP10 gdf7 IFNAR1 TNFSF14 IL8RB GDF1 GDF6 CD27 RELT TNFRSF10A IFNB1 GHB2 CD40 CLCF1 NGF TNLG8A TNFRSF8 CSF2RA PPBP IL13RA2 TNFRSF17 PF4 INHBC IL17RB BMP5 IL17RA IL18RAP INHBE IL7R ACVR1C CNTF ACKR4 IL1R2 TNFRSF1A IL18R1 CX3CR1 LTA TNFSF6 IL5RA IL13 CSF2RB TNFRSF19 IL6ST FAS IL12RB1 GDF11 EPO TNFRSF11B GDF3 EPOR TNFRSF11A TNFSF11 IL3RA LIF IL19 LTB TNLG7A TNLG7C INHBA BMP4 EDAR IL1RL1 IL34 TNFRSF4 TNFRSF18 IL18 BMP7 LEP TNF TGFBR2 IL6 TNLG2B CXCL8 BMP8B LTBR PEROXIREDOXIN 2 INDUCED OVARIAN FAILURE%WIKIPATHWAYS_20260510%WP4873%HOMO SAPIENS Peroxiredoxin 2 induced ovarian failure BAX MAPK10 HSD3B2 PARP2 CASP3 HEL-S-2a CYP11A1 STAR HYPOXIA MEDIATED EMT AND STEMNESS%WIKIPATHWAYS_20260510%WP2943%HOMO SAPIENS Hypoxia mediated EMT and stemness DICER1 NF KB SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260510%WP5527%HOMO SAPIENS NF kB signaling and ARTD family members TFPI2 BTRC CLDN6 EP300 SKP1 RBX1 RIGI IKBKB CREBBP PARP14 NFKBIA CHUK IKBKG MAP3K14 RELB MAVS GSK3B NFKB2 ZC3HAV1 TIPARP PARP16 PARP12 PARP1 PARP10 TBK1 ERN1 PARKIN UBIQUITIN PROTEASOMAL SYSTEM PATHWAY%WIKIPATHWAYS_20260510%WP2359%HOMO SAPIENS Parkin ubiquitin proteasomal system pathway PSMC1 CASP8 PARK2 STUB1 HEL-S-91n HSPA4 PSMC6 TUBAL3 TUBB8 PSMC4 TUBA3E TUBA1C SIAH1 TUBB6 TUBA1B TUBA1A TUBB1 TUBB FBXW7 TUBB4B PSMD2 TUBB4A TUBA4A TUBB2A SIAH2 TUBA2 TUBA8 UBE2L6 HEL-S-103 GPR37 UBE2G1 UBE2G2 UBE2J1 SNCAIP SEPT5 PSMD7 PSMD10 PSMD5 PSMD12 PSMD13 HEL-S-89n PSMD11 SNCA HEL-S-72p UBE2J2 PSMD9 PSMD6 CCNE1 PSMD4 PSMD3 PSMD1 CASK RNF19A HSPA2 TUBA4B HSPA14 MACROPHAGE STIMULATING PROTEIN MSP SIGNALING%WIKIPATHWAYS_20260510%WP5353%HOMO SAPIENS Macrophage stimulating protein MSP signaling RPS6KA3 SLPI CSF2 PRKAA2 RELA ACACA NR0B2 MAPK9 MAPK8 IL10 FLT1 PLCG1 MAPK3 PTEN TGFB1 IGF1R RPS6 RPS6KB1 HEL113 MAPK14 SMAD2 CPT1A KDR MST1R SOCS1 PDGFRA KLK15 MAP2K2 CCL2 CTNNB1 SOCS3 SMAD1 SMAD9 CRKL DUSP4 DKFZp781O1323 PDPK1 JUN SMAD6 SP7 SHC1 SRC PCNA RPS6KA4 HEL-S-102 TJP1 CLDN1 HK2 CDH2 CSF3 EGR1 ITGB1 MTOR FZD1 GRB2 FGFR1 IL1B WNT10B RPS6KA5 CXCL1 MAPK1 CXCL2 RAF1 HEL-S-133P CXCL5 NFKB1 MMP9 TNF PIK3R1 IL6 BGLAP IBSP RPS6KA1 COL4A1 IFNB1 GSK3B CXCL8 VEGFA PRKCB CLDN5 SIX1 ZEB2 MAP2K1 PARP1 ACTA2 SNAI2 FOS PPARGC1A 10Q22Q23 COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5402%HOMO SAPIENS 10q22q23 copy number variation SH2D4B FAM25A BUB1B ADIRF LDB3 GHITM CDHR1 DYDC2 ZMYND11 RGR GPR15LG SNCG GPR15 SUSD2 TSPAN14 RSPH1 LRIT2 GLUD1 SHLD3 LRIT1 PRXL2A SHLD2 SHLD1 RAD21 CCSER2 ACTN2 STAG1 TNFSF11 SMC1A BMP2 MAT1A ROPN1L BMPR1A NRG3 RSPH6A DNAJB13 MAD2L2 DYDC1 PPARG OPN4 RSPH14 IQUB NFKB1 NME5 CEBPA PDS5B RSPH9 PDS5A WAPAL ERBB4 SH3GL3 RSPH3 MMRN2 MGRA VEGFA SMC3 ADAM10 SIRT4 NEPHROTIC SYNDROME%WIKIPATHWAYS_20260510%WP4758%HOMO SAPIENS Nephrotic syndrome CTLA4 LAMB2 COQ6 HEL-S-47e LMNA SMARCAL1 GPC5 CYP11B2 YARS ALG1 CD151 ARHGAP24 PLCE1 ZMPSTE24 WT1 SCARB2 PTPRO APOL1 SYNPO PAX2 E2F3 COQ8B TRPC6 EMP2 LMX1B COL4A4 ACTN4 COL4A3 CD2AP INF2 COL4A5 MYH9 ITGB4 MYO1E NPHS1 NPHS2 WDR73 CUBN COQ2 STEROID BIOSYNTHESIS%WIKIPATHWAYS_20260510%WP496%HOMO SAPIENS Steroid biosynthesis HSD17B7 HSD17B3 CPN1 HSD17B2 HSD3B2 HSD17B1 HSD3B1 HSD17B4 F13B CYP17A1 MARKERS OF KIDNEY CELL LINEAGE%WIKIPATHWAYS_20260510%WP5236%HOMO SAPIENS Markers of kidney cell lineage CITED1 KDR DACT1 KCTD1 EPO PECAM1 TSHZ3 TBX18 VSX2 FGF7 TLX1 FGF8 AXIN2 EMX2 SMAD1 KIT DCN SFRP1 RSPO1 DKFZp781O1323 FOXD1 WNT4 NPHS1 TNC NPHS2 GDNF SALL1 EYA1 LHX1 FAT4 TCF2 NTN1 PBX1 HNF1A BMP4 BMP7 NT5E WT1 OSR1 TCF21 PAX2 SIX2 NOTCH2 ALDH1A2 RSPO3 NOTCH1 REN tmp_locus_29 SIX1 NR2A1 EGLN1 EGLN3 ACTA2 EGLN2 TRIACYLGLYCERIDE SYNTHESIS%WIKIPATHWAYS_20260510%WP325%HOMO SAPIENS Triacylglyceride synthesis PLPP2 PLPP1 AGPAT5 AGPAT4 MOGAT3 GPAM GPD1 MOGAT2 DGAT1 MOGAT1 LIPE AGPAT3 LIPC LPL LIPF GNPAT DGAT2 AGPS PNPLA2 PLPP3 COVID 19 THROMBOSIS AND ANTICOAGULATION%WIKIPATHWAYS_20260510%WP4927%HOMO SAPIENS COVID 19 thrombosis and anticoagulation PLG F2 HEL-S-78p F13A1 FGA F13B LAC PHE PATHWAY%WIKIPATHWAYS_20260510%WP5239%HOMO SAPIENS Lac Phe pathway CNDP2 ABCC5 EICOSANOID METABOLISM VIA CYTOCHROME P450 MONOOXYGENASES PATHWAY%WIKIPATHWAYS_20260510%WP4720%HOMO SAPIENS Eicosanoid metabolism via cytochrome P450 monooxygenases pathway CYP4F12 EPHX2 CYP4A11 CYP2C18 CYP4F2 CYP4A22 PPARG NR1C1 CYP2C8 HEPATITIS B INFECTION%WIKIPATHWAYS_20260510%WP4666%HOMO SAPIENS Hepatitis B infection CREB1 EP300 MAP2K3 TLR4 RELA JAK3 MAPK9 MAPK8 MAPK3 TGFB1 BRAF MAPK14 SMAD2 SMAD4 BCL2 TIRAP JUN PIK3CA NFATC3 PCNA NFATC4 IFNA1 MAP3K7IP1 ATF2 IF1AA9 IRAK1 IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 IFNA21 IKBKB MAP3K1 CHUK TRAF6 MAPK1 IKBKG RAF1 NFKB1 IFNA4 MAP2K6 IFNA7 MAPK13 IFNA6 IFNA2 IFNA8 CASP10 IFNAR1 IFNB1 STAT2 PRKCB MAP3K7 PRKCA TICAM2 VDAC3 APAF1 MAPK12 MAPK11 CASP8 TNFSF6 FADD CDKN1A JAK1 DDB1 STAT5B CREBBP PIK3CD STAT1 IRAK4 MYC AKT3 FAS CYCS STAT4 TYK2 HRAS TGFBR1 MAP2K2 HSPG2 MYD88 YWHAQ NFATC1 HEL-S-1 SOS1 SOS2 MAP2K4 YWHAZ SRC IFIH1 TBK1 NFATC2 IKBKE TICAM1 STAT3 IRF3 MAPK10 IRF7 TLR3 RIGI KRAS GRB2 BIRC5 ATF6B CREB3L3 CREB3L4 CREB3L2 ARAF PTK2B CREB3 MMP9 CREB5 ATF4 DDB2 PIK3R3 TNF PIK3R2 PIK3R1 TGFBR2 MAVS DDX3X NRAS EGR2 IL6 TRAF3 BAD CXCL8 BAX CASP9 CASP12 CASP3 MAP2K1 FOS DNA IR DOUBLE STRAND BREAKS AND CELLULAR RESPONSE VIA ATM%WIKIPATHWAYS_20260510%WP3959%HOMO SAPIENS DNA IR double strand breaks and cellular response via ATM YAP1 CHEK1 MRE11A NBN APAF1 BRCA2 RIF1 BRCA1 CDKN2A MDM2 ACTL6A CDK5 RAD9A PRKDC TP73 TRAF6 BLM MDC1 RASSF1 HSF1 RNF8 TERF2 FANCD2 ATR NABP2 MCPH1 SMC1A BAK1 TP53BP1 BAX H2AX CASP9 RAD52 RAD17 PCNA TRIM28 CASP3 LATS1 ATM SMC3 ATF2 PARP1 KAT5 RAD50 CHEK2 RAD51 TARGETED AGENTS IN TRIPLE NEGATIVE BREAST CANCER%WIKIPATHWAYS_20260510%WP5215%HOMO SAPIENS Targeted agents in triple negative breast cancer MTOR PARP2 KRAS GRB2 MAPK3 PTEN ARAF RPTOR RPS6KB1 DEPTOR BRAF MAPK1 RAF1 AKT3 MLST8 HRAS MAP2K2 PIK3R1 TSC2 INPP4B NRAS TSC1 AKT1S1 MAPKAP1 SOS1 RICTOR SOS2 PIK3CA IRS1 MAP2K1 PARP1 EIF4EBP1 IDO METABOLIC PATHWAY%WIKIPATHWAYS_20260510%WP5414%HOMO SAPIENS IDO metabolic pathway IFNG AADAT TNF GOT2 IDO1 TDO2 KYAT3 KYNU KYAT1 KMO IDO2 REGULATION OF CYTOTOXIC T CELL RESPONSES BY MALAT1 MIR 15 16 CIRCUIT %WIKIPATHWAYS_20260510%WP5489%HOMO SAPIENS Regulation of cytotoxic T cell responses by Malat1 miR 15 16 circuit BCL2 CD3G CD80 CD3E CD3D SPN IL2 CD27 NRXN1 DELETION SYNDROME%WIKIPATHWAYS_20260510%WP5398%HOMO SAPIENS NRXN1 deletion syndrome NLGN1 GRIN3B GRIN3A NRXN1 GRIN2B GRIN1 DLG4 GRIA3 GRIA2 NLGN3 NLGN2 GRIA4 SOLUBLE ACE2 MEDIATED CELL ENTRY OF SARS COV 2%WIKIPATHWAYS_20260510%WP5076%HOMO SAPIENS Soluble ACE2 mediated cell entry of SARS CoV 2 ACE2 AGTR1 AVPR1B ADAM17 DNA MISMATCH REPAIR%WIKIPATHWAYS_20260510%WP531%HOMO SAPIENS DNA mismatch repair POLE2 POLD2 RPA3 MSH2 PMS2 POLE RFC3 RFC4 LIG1 RFC1 POLE4 RFC2 MSH6 POLD3 POLE3 PCNA RPA1 POLD4 VITAMIN A AND CAROTENOID METABOLISM%WIKIPATHWAYS_20260510%WP716%HOMO SAPIENS Vitamin A and carotenoid metabolism BCO1 NR1B3 RARB SULT2B1 RDH8 RLBP1 RPE65 RDH12 RBP1 RDH10 RDH5 LRAT ADH1A MAPK1 HEL-S-53e CYP26A1 CYP2E1 HEL-S-4 CD36 ABCG8 ABCG5 RXRA DGAT1 SCARB1 LPL CYP26B1 ALDH1A2 RETSAT RARA DHRS3 RBP7 RBP4 RBP2 NPC1L1 SULT1A1 CRABP2 RXRB CRABP1 RXRG ALDH1A3 SDR16C5 AWAT2 NEUROGENESIS REGULATION IN THE OLFACTORY EPITHELIUM%WIKIPATHWAYS_20260510%WP5265%HOMO SAPIENS Neurogenesis regulation in the olfactory epithelium MAP2 MRE11A STAT3 RELN PAFAH1B1 AGRN TCF3 CDK5 ID1 HES1 PLXND1 NDEL1 PAX6 ID2 NTRK3 ASCL1 MYC CDK5R1 NEUROD1 BDNF DISC1 TCF4 NUMB ERBB4 RTN4 CXCL12 SOX2 VLDLR NOTCH1 APP DAB1 NGF RET GSK3B RTN4R LRP8 NRG1 NEUROG3 FAIM IL17A KDM1A GHRL PSEN1 MAP1B NTRK1 NGFR NTRK2 MEF2C APOPTOSIS MODULATION AND SIGNALING%WIKIPATHWAYS_20260510%WP1772%HOMO SAPIENS Apoptosis modulation and signaling PRKD1 DIABLO BAG3 MCL1 APAF1 BBC3 TNFSF10 BIRC7 HTRA2 BMF CASP8 BCL2L11 TNFSF6 FADD BCL2L1 BOK SMIM40 MAPK8 IL1R1 MAPK3 AIFM1 FAS CYCS BCL2 TNFRSF10B PTPN13 SEPTIN4 MYD88 TNFRSF1B JUN TNFRSF6B PTRH2 NAIP BCL2L10 TNFRSF10D IRAK1 MADD PIDD1 CDKN2A BIK BIRC5 IKBKB BIRC3 NFKBIA TRADD TRAF6 HRK CASP4 MAP3K14 BLK TNFRSF10C NFKB1 TNFRSF25 CAPNS1 CASP10 CRADD BCL2L2 TRAF3 CASP6 BIRC2 CASP2 BAK1 BCL2A1 DFFB RIPK1 BAD DFFA PMAIP1 TNFRSF10A BAX CASP9 CASP3 MAP3K5 IL1R2 TNFRSF1A AIFM2 BNIP3 FOS SUPPRESSION OF HMGB1 MEDIATED INFLAMMATION BY THBD%WIKIPATHWAYS_20260510%WP4479%HOMO SAPIENS Suppression of HMGB1 mediated inflammation by THBD IKBKB THBD NFKBIA CHUK HMGB1 RELA IKBKG AGER NFKB1 DEREGULATING CELLULAR METABOLISM THROUGH NON GENOTOXIC CARCINOGENS%WIKIPATHWAYS_20260510%WP5571%HOMO SAPIENS Deregulating cellular metabolism through non genotoxic carcinogens SESN2 EIF2A TSC2 TSC1 MTOR MARS1 LONP1 SLC7A7 CLPP IRS1 OMA1 FOXO1 HSPD1 LONP2 MYC GDF15 PHB2 ATF4 RNA POLYMERASE II TRANSCRIPTION THE PREINITIATION COMPLEX%WIKIPATHWAYS_20260510%WP5563%HOMO SAPIENS RNA polymerase II transcription the preinitiation complex POLR2B POLR2D NELFCD POLR2G POLR2I POLR2J MED9 POLR2F POLR2H POLR2K POLR2L MED23 TAF13 TAF1 TAF8 MED27 NELFA CTDP1 CDK8 TAF5 GTF2B MED19 MED16 MED18 MED17 MED12 MED11 THRA MED13 MED10 NELFB MED8 MED4 GTF2F1 MED26 MED6 MED29 MED28 MED22 MED25 MED24 MED21 GTF2A1 TAF9 GTF2E2 MED30 MED31 POLR2M TAF10 POLR2C TAF11 MED1 TBP TRFP TAF7 TAF6 CRSP9 TAF4 TAF3 MED14 MED15 TAF12 CCNC POLR2A ENDOCHONDRAL OSSIFICATION WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260510%WP4808%HOMO SAPIENS Endochondral ossification with skeletal dysplasias PLAT STAT5B TGFB1 MGP SOX6 STAT1 IGF1R GHR IGF2 FGF2 CALM1 CDKN1C RUNX3 BMP6 BMPR1A GLI3 IGF1 MEF2C THRA FGF18 IHH PTH1R PTHLH PTH FRZB PTCH1 CHST11 RUNX2 ALPL FGFR3 FGFR1 MMP9 BMP7 GH1 ACAN SPP1 COL10A1 ADAMTS4 SOX9 ADAMTS5 ENPP1 TIMP3 HMGCS1 NKX3-2 KIF3A SOX5 CAB39 CST5 VEGFA COL2A1 SCIN DDR2 PEPTIDE GPCRS%WIKIPATHWAYS_20260510%WP24%HOMO SAPIENS Peptide GPCRs EDNRA EDNRB C5AR1 AVPR2 CCR5 CXCR4 CXCR3 LHCGR AVPR1B NPY1R FPR2 MC1R GRPR TACR1 GNRHR CCR3 CCR10 CCR1 CCR8 FPR1 CCR7 CCR6 CCR4 CXCR1 CCR2 CCKBR FSHR BDKRB2 SSTR2 BDKRB1 CXCR5 CXCR6 MC3R FY AGTR1 NTSR1 AGTR2 ATP8A1 BRS3 CCKAR NPY5R OXTR TACR2 NPY2R TACR3 C3AR1 OPRM1 AVPR1A SSTR3 SSTR4 FPRL2 TRHR SSTR5 OPRD1 IL8RB NPY4R OPRK1 MC2R GALR3 GALR2 TSHR GALR1 TAC4 HCRTR2 MC4R NTSR2 HCRTR1 MC5R NMBR CX3CR1 GHSR NANOPARTICLE MEDIATED ACTIVATION OF RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP2643%HOMO SAPIENS Nanoparticle mediated activation of receptor signaling MAPK12 MAPK10 ITGB1 MAPK11 KRAS MAPK9 GRB2 MAPK8 ITGA1 PIK3CD MAPK1 MAPK14 RAF1 AKT3 MAPK13 HRAS TLN1 MAP2K2 NRAS AREG SOS1 PXN COL1A1 SRC EGFR MAP2K1 CAFFEINE IN NEURONS%WIKIPATHWAYS_20260510%WP5602%HOMO SAPIENS Caffeine in neurons ADORA2A ADRA1D ADRA1B ADRA1A MINERALOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260510%WP5279%HOMO SAPIENS Mineralocorticoid biosynthesis HSD11B1 AKR1C4 UGT2B7 HSD11B2 CYP21A2 SRD5A2 AKR1C1 UGT1A10 CYP11B2 AKR1C2 AKR1D1 ZINC HOMEOSTASIS%WIKIPATHWAYS_20260510%WP3529%HOMO SAPIENS Zinc homeostasis MT1A MTF1 MT1F MT1G SLC39A9 MT1B SLC39A6 SLC39A5 SLC39A8 MT1E SLC39A2 SLC39A1 SLC39A3 SLC39A11 SLC39A10 MT2A SLC39A13 SLC39A12 MT1M SLC39A14 SLC30A10 SLC30A7 SLC30A6 SLC30A9 SLC30A8 SLC30A2 SLC30A5 SLC30A4 MT4 SLC30A1 MT3 UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260510%WP4925%HOMO SAPIENS Unfolded protein response BCL2 PPP1R15A TNFRSF10B BBC3 TXNIP BCL2L11 MBTPS1 CASP2 EIF2S1 PMAIP1 IL1B MBTPS2 HEL-S-89n NFE2L2 DDIT3 XBP1 RTCB ATF4 ERN1 PRO SURVIVAL SIGNALING OF NEUROPROTECTIN D1%WIKIPATHWAYS_20260510%WP5182%HOMO SAPIENS Pro survival signaling of neuroprotectin D1 TNF TRAF2 CASP8 FADD RIPK1 RIPK3 BAX CASP9 BIRC3 TRADD CASP3 TNFRSF1A CYCS NCRNAS IN WNT SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260510%WP4336%HOMO SAPIENS ncRNAs in Wnt signaling in hepatocellular carcinoma CSNK1A1L SOX17 CER1 CSNK2A3 CSNK2A2 CTNNBIP1 DKK2 SFRP5 MTDH SOX7 CSNK2B PORCN CHD8 SOST KREMEN1 SENP2 CCND1 CXXC4 MYC NKD1 NKD2 WIF1 FOSL1 NOTUM CTNNB1 DKK1 CTBP1 SFRP1 NLK FRAT1 DVL1 DVL2 JUN DVL3 WNT4 TCF7L2 LEF1 RYK AXIN1 LRP5 CSNK1E ROR1 CTBP2 ROR2 LRP6 WNT1 CSNK1A1 TCF7L1 WNT2B CSNK2A1 FZD10 ELAVL1 APC WNT5B WNT16 FZD1 SFRP4 KLF4 EZH2 WNT3 WNT10B WNT10A FRAT2 FZD3 FZD2 FZD5 WNT3A WNT7B FZD7 DKK4 FZD9 WNT7A FZD8 GSK3B CCND3 CCND2 BONE MORPHOGENIC PROTEIN SIGNALING AND REGULATION%WIKIPATHWAYS_20260510%WP1425%HOMO SAPIENS Bone morphogenic protein signaling and regulation SMAD6 SMURF1 BMPR1A BMPR2 TOB1 SMAD1 NOG SMAD4 BMP2 TOB2 RUNX2 ALA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260510%WP5136%HOMO SAPIENS ALA oxylipin metabolism ALOX5 EPHX2 ALOX15 SODIUM CHANNEL IN EPILEPSY%WIKIPATHWAYS_20260510%WP5598%HOMO SAPIENS Sodium channel in epilepsy PDCD10 SCN7A FGF14 MAPK8IP2 SCNM1 FGF13 FYN SCN4A FGF12 RNF121 SCN3B SCN5A SCN3A SCN1A PRRT2 SCN2B SCN8A SCN2A SCN1B SCN4B CALM1 TNF NEDD4 SCN9A SCN10A GSK3B PSEN1 CAMK2A BACE1 PTPRN SCN11A WEE1 AFFECTED PATHWAYS IN DUCHENNE MUSCULAR DYSTROPHY%WIKIPATHWAYS_20260510%WP5356%HOMO SAPIENS Affected pathways in Duchenne muscular dystrophy TNNI1 ITPR2 PRKAA2 MCUB SCX TOMM20 TRDN ATP2A1 DAG1 CACNA1S IL10 IL1A TGFB1 CYBB TRPC1 SSPN SNTB1 SMAD2 SMAD4 TGFBR1 RYR1 CACNA1F CACNG1 TRPC6 MPO SLN CASQ1 CAMK2D CACNA2D1 FGA SLC25A5 CAPN3 HEL-S-78p ELANE PLA2G2A NOS2 STIM1 IL1B NFKBIA FKBP1A AGTR1 MMP2 NFKB1 MMP9 PRG3 PPIF TNF TGFBR2 CTGF IL6 SGCA SPP1 TRPC3 PRKAA1 DMD CASP9 SIGMAR1 MCU CACNB1 ORAI1 NOX4 IL3 SIGNALING%WIKIPATHWAYS_20260510%WP286%HOMO SAPIENS IL3 signaling INPP5D STAT3 FYN GAB2 PTPN6 BCL2L1 GRB2 IL5RA MAPK8 CSF2RB MAPK3 JAK1 RAPGEF1 LYN STAT5B TGFB1 PIK3CD SYK VAV1 MAPK1 RAF1 HRAS BCL2 PIK3R2 PIK3R1 IL3 IL3RA CD69 YWHAQ BAD CRKL HEL-S-1 ENPP3 PTPN11 SOS1 CXCL8 JUN SHC1 SRC MAP2K1 CBL FOS CCR3 FACT COMPLEX AND DNA DOUBLE STRAND BREAK REPAIR%WIKIPATHWAYS_20260510%WP5564%HOMO SAPIENS FACT complex and DNA double strand break repair NBN H1-1 TP53BP1 PRKDC XRCC5 ATM H4C9 RNF168 MDC1 SUPT16H HIST1H4L SSRP1 SETD2 RNF8 NASP RAD51 NON GENOMIC ACTIONS OF 1 25 DIHYDROXYVITAMIN D3%WIKIPATHWAYS_20260510%WP4341%HOMO SAPIENS Non genomic actions of 1 25 dihydroxyvitamin D3 TLR4 MAPK12 MAPK11 PRKCZ IFI27L2 MAPK9 RSAD2 MAPK8 PLCG2 PLCB1 JAK1 MAPK3 STAT1 CD40LG MAPK14 CAMP DEFB4B IFNGR1 PLCE1 TYK2 HRAS SP1 IFNG CCL2 PLCB4 RXRA JUN PLCB3 CAMK2D CAMK2A OAS2 IFI44L KRAS CYP27B1 CAMK2G CYP24A1 IKBKB MAPK7 MED1 MAPK1 PLCB2 NFKB1 MAPK13 IFNA2 NR1i1 IFNAR2 TNF RELB NRAS IL6 CD40 STAT2 CXCL8 PRKCH PRKCB NFKB2 PRKCE PRKCA TLR8 IFNGR2 TNFRSF1A RXRB RXRG SP3 NOD2 ISG15 PRKCQ CLOCK CONTROLLED AUTOPHAGY IN BONE METABOLISM%WIKIPATHWAYS_20260510%WP5205%HOMO SAPIENS Clock controlled autophagy in bone metabolism CTSK CTHRC1 CSF1 PRKAA2 SEMA3A ARHGAP4 FYCO1 DRAM2 VCP SEMA4D TGFB1 ULK1 LAMP2 SOST DKFZp762B153 SMAD4 MAP1LC3A AMBRA1 ATG5 ATG3 TNFRSF11B ATG101 ATG10 TNFRSF11A BCL2 TNFSF11 CRY1 IL3 ATG12 SMAD1 SMAD9 ATG16L1 DKK1 NFATC1 BMP6 BMP2 PLEKHM1 DKFZp781O1323 PER1 RB1CC1 SP7 EFNB2 LRP5 BMPR2 IGF1 RORB MTOR HMGB1 PTH WNT16 BHLHB2 RUNX2 BMP4 SQSTM1 BHLHE41 WNT10B CTF1 TRAF6 LEP BMP3 NPAS2 IL6 NOTCH1 CALCA BMP5 NR1D2 7 OXO C AND 7 BETA HC PATHWAYS%WIKIPATHWAYS_20260510%WP5064%HOMO SAPIENS 7 oxo C and 7 beta HC pathways HSD11B1 CYP7A1 HSD11B2 DHCR7 NPC1 DBP NPC2 THEM5 ACOT9 ACOT8 ACOT7 ACOT11 ACOT12 ACOT13 BAAT EBP ACOT6 CYP27A1 ACOT4 EPHX2 AMACR SLC27A5 SLC27A2 EXERCISE AND HYPERTROPHY IN SKELETAL MUSCLE%WIKIPATHWAYS_20260510%WP516%HOMO SAPIENS Exercise and hypertrophy in skeletal muscle IFNG ANKRD1 CYR61 ATF3 GDF8 MYOG IL1R1 DUSP14 IL1A EIF4E HEL-S-52 VEGFA JUND ADAM10 HBEGF IFRD1 IL18 EIF4EBP1 NR4A3 NPHP1 DELETION SYNDROME%WIKIPATHWAYS_20260510%WP5399%HOMO SAPIENS NPHP1 deletion syndrome FLNB MAPK3 NPHP1 INVS RPGRIP1L PTK2B MAPK1 FLNA N GLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260510%WP5153%HOMO SAPIENS N glycan biosynthesis RFT1 DPAGT1 GMPPB MAN1A2 MAN1A1 ALG8 ST6GAL1 ALG9 ST6GAL2 ALG5 ALG1 ALG2 ALG14 ALG13 ALG3 ALG12 ALG11 ALG10 DDOST DPM3 GCS1 MAN1B1 ALG10B FUT8 GANAB TUSC3 MAN2A2 MAN2A1 DPM2 MGAT5 MGAT5B MGAT3 MGAT2 SRD5A3 DOLK MGAT4C MGAT4D MGAT4A DOLPP1 MGAT4B MGAT1 STT3A STT3B B4GALT2 ALG6 RPN2 RPN1 DPM1 B4GALT1 MPDU1 PROTEOGLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260510%WP4784%HOMO SAPIENS Proteoglycan biosynthesis CHST3 XYLT1 PAPSS2 EXT1 XYLT2 CHST14 EXT2 CHSY1 CSGALNACT1 SLC35B2 B3GAT3 CANT1 BPNT2 SLC26A2 B3GALT6 PRADER WILLI AND ANGELMAN SYNDROME%WIKIPATHWAYS_20260510%WP3998%HOMO SAPIENS Prader Willi and Angelman syndrome NIPA1 LHB TUBGCP6 TUBGCP4 NIPA2 NUP107 ATP10A FMR1 PRKCZ GNRH1 AHCTF1 DLX5 CCND1 SNURF POMC RNF8 CDC6 HERC2 NUP62 MSX1 TYR RB1 NUP85 NUP188 NPAP1 NUP214 CDKN2B NDC1 CDKN2C GOLGA8S PCSK1 NUP210 GOLGA6L2 NUP93 FEZ1 FEZ2 NUP54 NUP58 OCA2 NUP205 SLC45A2 CDKN2A SEH1L MDM2 AAAS HEL-S-71 BBS4 NUP160 MAGEL2 NHLH2 TPR NUP42 RANBP2 CDK6 NUP155 NUP153 CDK4 NUP35 MKRN3 NUP88 GABRG3 GABRG2 GABRG1 NDN TACR3 OXT POM121 BDNF GABRB3 SNRPN FSHB NUP98 PCM1 CGA RAE1 NGF GABRR3 KISS1 MDM4 GABRR1 EIF4E GHRH UBE3A GHRL NUP133 GABRA5 CCND2 INS CYFIP1 TUBGCP5 VITAMINS A AND D ACTION MECHANISMS%WIKIPATHWAYS_20260510%WP4342%HOMO SAPIENS Vitamins A and D action mechanisms RXRA RARA NR1i1 INHIBITORS OF METABOLISM IN MELANOMA THERAPY%WIKIPATHWAYS_20260510%WP5609%HOMO SAPIENS Inhibitors of metabolism in melanoma therapy RPS6KA3 PKLR DLAT MTOR GLS SLC16A3 MAPK3 LDHB HEL-S-304 ARAF PFKFB2 RPTOR DLD BRAF HEL-S-30 MAPK1 CPT1A HEL-S-133P RAF1 MLST8 MAP2K2 GPX4 RPS6KA2 RPS6KA1 NAMPT ACSS1 HEL-75 PDHA1 MAP2K1 PPARGC1A HIJACK OF UBIQUITINATION BY SARS COV 2%WIKIPATHWAYS_20260510%WP4860%HOMO SAPIENS Hijack of ubiquitination by SARS CoV 2 CBFB UBA3 ELOC RBX1 NAE1 STEROL REGULATORY ELEMENT BINDING PROTEINS SREBP SIGNALING%WIKIPATHWAYS_20260510%WP1982%HOMO SAPIENS Sterol regulatory element binding proteins SREBP signaling CREB1 PRKAA2 ACACA GSK3A SEC23A LPIN1 CAMP DBI SP1 SCARB1 INSIG1 LPL MBTPS1 LDLR RBP4 SAR1B PIK3CA CDK8 MBTPS2 SCD FASN FGF21 HEL-S-32 SQLE ACLY MTOR PPARG SAR1A RNF139 PRKAB2 SEC23B SEC31B PRKAB1 SEC31A AMFR NFYA SEC24C YY1 MED15 PPARGC1B GPAM SIRT1 PRKAG1 PRKAG2 PRKAG3 PRKAA1 ACSS1 HMGCS1 SREBF2 HMGCR IDI1 FDPS INS MVD NR1H2 FDFT1 CYP51A1 GLUCOCORTICOID RECEPTOR PATHWAY%WIKIPATHWAYS_20260510%WP2880%HOMO SAPIENS Glucocorticoid receptor pathway DNAJC15 ARL5B SRGN NAV3 ADGRF4 PRRG4 PPP1R14C SLC19A2 S100P NR3C1 ALOX5AP IL11 STOM PTGES3 CCL2 THBD ANKRD1 CDKN1C RXRA TNFAIP3 ACKR3 JUN POU5F1 DNER ZIC2 TNS4 TGFBR3 FGFBP1 BHLHB2 BIRC3 SPRY1 PDE4B CCL20 AMIGO2 MGAM RGS2 B3GNT5 ANGPTL4 BIRC2 GADD45B PTGS2 PLK2 CPEB4 EPB41L4B ENC1 EDN2 TSC22D3 CDC42EP3 NFKB2 PMP2 MFGE8 FGD4 GPR153 SERTAD2 CAVIN2 KTN1 NR1i2 SCNN1A SLC26A2 NR1I3 SNAI2 ABHD2 LEPTIN SIGNALING%WIKIPATHWAYS_20260510%WP2034%HOMO SAPIENS Leptin signaling CREB1 SOCS2 PRKAA2 RELA ACACA GSK3A MAPK8 PLCG2 CISH PLCG1 JAK1 MAPK3 PTEN STAT5B STAT1 RPS6 NCOA1 RPS6KB1 KHDRBS1 ACACB MAPK14 ARHA HRAS SP1 MAP2K2 CFL2 SOCS3 SOS1 SHC1 SRC FOXO1 EIF4EBP1 PTPN1 STAT3 FYN MTOR REL GRB2 IKBKB CHUK SH2B1 MAPK1 IKBKG RAC1 RAF1 ROCK1 ROCK2 KPNA4 NFKB1 LEP CDC42 PIK3R2 PIK3R1 RPS6KA1 PRKAA1 BAD PTPN11 GSK3B EIF4E SOCS7 PDE3B IRS1 MAP2K1 LEPR ERBB2 KETOGENESIS AND KETOLYSIS%WIKIPATHWAYS_20260510%WP4742%HOMO SAPIENS Ketogenesis and ketolysis BDH1 OXCT1 CPT2 UCP2 SLC25A20 ACAT1 16P11 2 PROXIMAL DELETION SYNDROME%WIKIPATHWAYS_20260510%WP4949%HOMO SAPIENS 16p11 2 proximal deletion syndrome PAGR1 MAP2K3 CASP8 NR3C1 CDIPT HDAC3 MAPK3 PTEN PPP2R1A UNC13A PPP2R5D BPTF PPP2CA SIAH1 SPN HEL70 TBX6 SMEK1 EZR PARP4 PPP4R3B PCNA CCT7 TAOK2 REL KMT2C PPARG CCT6B MLL2 TRAF6 HEL-S-87p PRRT2 NFKB1 DOC2A MAP2K6 FAM57B FIMP PPP4R1 PPP4R2 PPP4R4 CCDC6 HEL-S-69 TRAF2 ASPHD1 TCP1 HEL-S-90n KCTD13 ZG16 PAXIP1 INO80E MVP HIRA GDPD3 CORO1A HIRIP3 PPP4C CCT8 CCT4 IGBP1 HEL-S-100n C16orf54 CCT6A YPEL3 UNC13B TAMOXIFEN METABOLISM%WIKIPATHWAYS_20260510%WP691%HOMO SAPIENS Tamoxifen metabolism UGT2B7 UGT2B15 UGT1A10 SULT1E1 UGT1A8 CYP3A4 CYP2C19 CYP1B1 CYP2C9 CYP2C8 UGT1A4 CYP1A2 SULT1A1 CYP2A6 SULT2A1 CYP1A1 CYP2E1 ANGIOGENESIS OVERVIEW%WIKIPATHWAYS_20260510%WP1993%HOMO SAPIENS Angiogenesis overview NRP1 SEMA3A MAPK11 MAPK8 ROBO4 DAG1 PLCG1 PIK3CD MAPK14 KDR ANGPT1 SOS1 PLA2G1B NCK1 MAP2K4 PDPK1 PXN IQGAP1 SHC1 SRC SHB CRK ROBO1 ATF2 MTOR SLIT2 APC KRAS GRB2 PLXND1 FGFR1 MMP14 F2 PTK2B MAPK1 RAC1 RAF1 MMP2 WAS MMP9 MAP2K6 BMX CDC42 TIMP4 PAK1 FRS2 VHL BAD GRB14 PTPN11 VEGFA MAP3K7 PRKCA MAP2K1 NOX4 GRB7 HIF1A AND PPARG IN HYPERTROPHIC CARDIOMYOPATHY%WIKIPATHWAYS_20260510%WP2456%HOMO SAPIENS HIF1A and PPARG in hypertrophic cardiomyopathy HEL-S-49 GPD1 HMFN0839 HIF1A HEL-S-133P PPARG CD36 HEL-S-162eP MESODERMAL COMMITMENT PATHWAY%WIKIPATHWAYS_20260510%WP2857%HOMO SAPIENS Mesodermal commitment pathway NR1B3 YAP1 RARB ACACA ZFHX4 SCHIP1 HAND1 PAX6 SMAD2 SMAD4 TOX3 PPP2CA FGF8 TCF4 TET1 HES7 SMAD1 TBX6 DKK1 ARID5B BCORL1 LEFTY2 BMPR1A FOXC1 BMPR2 CTBP2 DNMT3B AMH ACVR1 ZIC2 ACVR2B KLF4 WNT3 FZD5 FZD4 WNT3A TOX FZD8 AEBP2 CSRP2 CCDC6 MIXL1 SLC2A12 HMGA2 ADAM19 FOXC2 TWSG1 MSGN1 ARL4A WDCP SETD2 PIAS1 PRKAR1A FOXA1 NODAL SOX17 SOX21 CEP250 WDHD1 VAV3 EMSY PBX3 ATP8B2 CUL4B WDFY2 CCND1 MBTD1 PLCH1 EPB41L5 UBR5 GDF3 LEFTY1 TRERF1 PITX2 NABP2 AXIN2 ACVR2A GATA3 TRIM71 SOX2 PHF6 NOG FOXH1 ZIC3 NLK TRIM5 PARP8 EXT1 SMAD6 AHDC1 EXT2 POU5F1 LEF1 AXIN1 ZNF462 ELP4 ZIC5 HPRT1 RPL38 C9orf72 CRTC1 TCF7L1 PBX1 TBX3 TEAD2 BHLHB2 INHBA JARID2 BMP4 FOXA2 FGFR1 C1QBP SNAI1 RGS10 BMP7 SESN1 MEIS1 KLF5 HTT TRIM28 NFE2L2 LATS1 NR2A1 GATA6 TBX1 REGULATION OF SISTER CHROMATID SEPARATION AT THE METAPHASE ANAPHASE TRANSITION%WIKIPATHWAYS_20260510%WP4240%HOMO SAPIENS Regulation of sister chromatid separation at the metaphase anaphase transition BUB1B APC SMC1A RAD21 SMC3 CDC20 MAD1L1 MAD2L1 CENPE ESPL1 PTTG1 STAG1 CHOLESTASIS%WIKIPATHWAYS_20260510%WP5238%HOMO SAPIENS Cholestasis ABCG8 ABCG5 RXRA SCARB1 ABCC3 ABCC2 LDLR ABCB4 SLCO1A2 HMGCR ABCB11 ATP8B1 EPHX1 NR1H4 SLC22A1 NR1I3 PHOSPHOINOSITIDE 3 KINASE PI3K FAMILY%WIKIPATHWAYS_20260510%WP5472%HOMO SAPIENS Phosphoinositide 3 kinase PI3K family PIK3CA PIK3R3 PIK3R2 PIK3CD PIK3R1 PIK3R4 PIK3C2G PIK3C2A PIK3C2B PIK3R5 KILLER CELL IMMUNOGLOBULIN LIKE RECEPTORS AND HUMAN LEUKOCYTE ANTIGEN C PATHWAY%WIKIPATHWAYS_20260510%WP5576%HOMO SAPIENS Killer cell immunoglobulin like receptors and human leukocyte antigen C pathway IFNG TNF CSF2 FYN PTPN6 CD34 HLA-C GRB2 PLCG1 LCP2 SYK LAT PRKCA VAV1 KIR2DL1 KIR2DL3 TYROBP RAC1 HRAS PRKCQ CCL18 SIGNALING%WIKIPATHWAYS_20260510%WP5097%HOMO SAPIENS CCL18 signaling CDH2 PTK2B CCR8 ZEB2 MMP2 AK4 PCSK9 MEDIATED LDL RECEPTOR DEGRADATION%WIKIPATHWAYS_20260510%WP2846%HOMO SAPIENS PCSK9 mediated LDL receptor degradation PCSK9 LDLR MITOCHONDRIAL CARRIER DEFICIENCY ASSOCIATED WITH SHUTTLE DISTURBANCES%WIKIPATHWAYS_20260510%WP5507%HOMO SAPIENS Mitochondrial carrier deficiency associated with shuttle disturbances GLUD1 SLC25A12 SLC25A22 GOT2 SLC25A13 10Q11 21Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP5352%HOMO SAPIENS 10q11 21q11 23 copy number variation syndrome RGMB BAZ1B ChAT WDFY4 PARG LRRC18 ARHGAP22 HSF4 DRGX SLC18A3 KDM4D C10orf53 SMARCA5 EIF4ENIF1 DEK MAPK8 TMEM273 UVSSA GDF5 CUL5 JUND ERCC5 DLD HSF1 BCL2 SMAD1 NOG SMAD9 MYBBP1A BMP2 DKFZp781O1323 MEN1 PCNA BMPR1A ITCH SF3B1 ELOA ATF2 SMARCC2 RIF1 DDX21 SIRT6 SIRT1 NEO1 NLRP3 MYO1C OGDHL FAM170B CEFIP VSTM4 TRANS SULFURATION ONE CARBON METABOLISM AND RELATED PATHWAYS%WIKIPATHWAYS_20260510%WP2525%HOMO SAPIENS Trans sulfuration one carbon metabolism and related pathways HEL-S-75p PCYT1B CHKB AHCYL1 PCYT2 SHMT1 CHKA SLC25A48 ETNK1 BHMT2 AMT pcap CEPT1 GPX7 ALDH7A1 MTHFD2L HEL-S-182mP GAD1 GAD2 HEL-S-44 PEMT DNMT3L BCAT1 BCAT2 AHCYL2 HEL-S-61p BAAT MAT1A MTHFD1L MTHFD1 MTHFD2 CHDH DNMT3B CBS MTR CDO1 PSAT1 PHGDH HEL-S-51e AGXT2 PSPH TYMS DHFR GPX4 GPX2 GPX1 GPX3 GPX6 HEL-S-64p HEL-75 GCLC CTH GCLM DEGRADATION PATHWAY OF SPHINGOLIPIDS INCLUDING DISEASES%WIKIPATHWAYS_20260510%WP4153%HOMO SAPIENS Degradation pathway of sphingolipids including diseases NEU4 HEXB HEXA SCARB2 NPC1 GLA NPC2 NEU2 GM2A PSAP NEU1 LIPA NEU3 GLB1 ESTROGEN METABOLISM%WIKIPATHWAYS_20260510%WP697%HOMO SAPIENS Estrogen metabolism UGT2B7 SULT1E1 UGT1A9 CYP3A4 CYP1B1 CYP1A2 UGT1A3 GSTM1 NQO1 ARSL SULT1A1 UGT1A1 STS CYP1A1 NUCLEOTIDE EXCISION REPAIR IN XERODERMA PIGMENTOSUM %WIKIPATHWAYS_20260510%WP5114%HOMO SAPIENS Nucleotide excision repair in xeroderma pigmentosum POLD2 GPS1 H3F3B CETN2 XPA BRCA1 RBX1 XPC POLE GTF2H2C_2 RFC3 RFC4 LIG1 RFC1 POLE4 RFC2 GTF2H2 UVSSA GTF2H3 GTF2H5 CUL4A POLD3 H2AC6 DDB1 ERCC1 POLE3 ERCC2 SLX4 MNAT1 CUL4B H4C9 SLX4IP HIST1H4L POLK RPA1 DDB2 CDK7 POLE2 CHD1L RPA3 HMGN1 RAD18 XAB2 PCNA CCNH PARP1 POLD4 PATHOGENESIS OF SARS COV 2 MEDIATED BY NSP9 NSP10 COMPLEX%WIKIPATHWAYS_20260510%WP4884%HOMO SAPIENS Pathogenesis of SARS CoV 2 mediated by nsp9 nsp10 complex CD8B1 ZAP70 CD8A LCK FYN IL6 MMP25 LBP NRF IGLL1 CRP CXCL8 CD3G HLA-DRB5 CD3E CD2 HLA-DRA HLA-DRB1 PRG3 ALTERNATIVE PATHWAY OF FETAL ANDROGEN SYNTHESIS%WIKIPATHWAYS_20260510%WP4524%HOMO SAPIENS Alternative pathway of fetal androgen synthesis AKR1C4 POR HSD17B3 SRD5A2 HSD3B2 HSD17B6 AKR1C2 CYP11A1 STAR CYP17A1 SEROTONIN TRANSPORTER ACTIVITY%WIKIPATHWAYS_20260510%WP1455%HOMO SAPIENS Serotonin transporter activity TPH2 IL1B TGFB1I1 MAOA ITGB3 IL1R1 STX1A VITAMIN A1 AND A5 X PATHWAYS%WIKIPATHWAYS_20260510%WP5397%HOMO SAPIENS Vitamin A1 and A5 X pathways NR1B3 RARB RXRA RXRB RXRG RARA FOLATE ALCOHOL AND CANCER PATHWAY HYPOTHESES%WIKIPATHWAYS_20260510%WP1589%HOMO SAPIENS Folate alcohol and cancer pathway hypotheses CREB1 CBS CEBPB MTR HEL-S-53e CYP2E1 ADH5 COVID 19 AND ENDOTHELIAL CELL SENESCENCE%WIKIPATHWAYS_20260510%WP5256%HOMO SAPIENS COVID 19 and endothelial cell senescence TLR4 IL17A IL17RA IL17RC SARS COV 2 REPLICATION ORGANELLE FORMATION%WIKIPATHWAYS_20260510%WP5156%HOMO SAPIENS SARS CoV 2 replication organelle formation PIK3R4 ACTIVATION OF NLRP3 INFLAMMASOME BY SARS COV 2%WIKIPATHWAYS_20260510%WP4876%HOMO SAPIENS Activation of NLRP3 inflammasome by SARS CoV 2 IL1B PYCARD TRAF3 RELA NLRP3 NFKB1 ROLES OF CERAMIDES IN DEVELOPMENT OF INSULIN RESISTANCE%WIKIPATHWAYS_20260510%WP5181%HOMO SAPIENS Roles of ceramides in development of insulin resistance INSR PPP2CA SLC2A4 TNF PIK3R1 PRKCZ PDX1 PRKAG3 MAPK8 ACSL1 MAFA TRAF1 RPS6KB1 IRS1 TNFRSF1A EIF2AK2 INS CD36 ERN1 AUTOPHAGY%WIKIPATHWAYS_20260510%WP4923%HOMO SAPIENS Autophagy MTOR PRKAA2 ATG9A ULK1 DKFZp762B153 RPTOR PRKAB2 DEPTOR PRKAB1 AMBRA1 MLST8 ATG5 ATG101 ATG3 UVRAG WIPI2 ATG14 ATG12 PRKAG1 PRKAG2 ATG16L1 AKT1S1 PRKAA1 PRKAG3 RB1CC1 PIK3R4 ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20260510%WP528%HOMO SAPIENS Acetylcholine synthesis ACHE ChAT PEMT PDHA2 PDHA1 CHKA SULFATASE AND AROMATASE PATHWAY%WIKIPATHWAYS_20260510%WP5368%HOMO SAPIENS Sulfatase and aromatase pathway HSD17B3 HSD17B2 SULT1E1 SLCO1B1 NR3A2 HSD17B1 HSD3B1 SLCO2B1 SLCO4C1 SLCO4A1 SLCO1A2 RANKL RANK SIGNALING%WIKIPATHWAYS_20260510%WP2018%HOMO SAPIENS RANKL RANK signaling MTOR GAB2 RELA PAPSS2 MAPK9 MAPK8 PLCG1 MAPK3 SPI1 LYN TRAF1 SQSTM1 IKBKB SYK NFKBIA STAT1 CHUK TRAF6 MAPK1 MAPK14 IKBKG RAC1 NFKB1 MAP2K6 TNFRSF11B CDC42 TNFRSF11A PIK3R2 PIK3R1 TRAF2 RELB TNFSF11 TRAF5 TRAF3 NFATC1 JUN NFKB2 SRC MAP3K7 FHL2 MAP3K7IP1 MAP2K1 CBL FOS 8Q11 23 RB1CC1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5412%HOMO SAPIENS 8q11 23 RB1CC1 copy number variation TNF TRAF2 ATG16L1 GABARAPL2 GABARAPL1 RB1CC1 PTK2B ULK1 GABARAP RB1 MAP3K5 WDR45B ATG101 VITAMIN D METABOLISM%WIKIPATHWAYS_20260510%WP1531%HOMO SAPIENS Vitamin D metabolism DHCR7 CYP27A1 RXRA RXRB PTH CYP27B1 CYP2R1 CYP24A1 GC NR1i1 DICLOFENAC METABOLIC PATHWAY%WIKIPATHWAYS_20260510%WP2491%HOMO SAPIENS Diclofenac metabolic pathway CYP2C18 CYP2B6 CYP2C19 CYP2C9 CYP2C8 LET 7 INHIBITION OF ES CELL REPROGRAMMING%WIKIPATHWAYS_20260510%WP3299%HOMO SAPIENS let 7 inhibition of ES cell reprogramming KLF4 EGR1 POU5F1 TRIM71 SOX2 MYC SARS COV 2 ALTERING ANGIOGENESIS VIA NRP1%WIKIPATHWAYS_20260510%WP5065%HOMO SAPIENS SARS CoV 2 altering angiogenesis via NRP1 FURIN VEGFA ACE2 NRP1 KDR HYPOTHESIZED PATHWAYS IN PATHOGENESIS OF CARDIOVASCULAR DISEASE%WIKIPATHWAYS_20260510%WP3668%HOMO SAPIENS Hypothesized pathways in pathogenesis of cardiovascular disease LTBP2 ANGPT2 TGFBR2 CTGF TGFBR3 MAPK8 ENG LTBP1 RUNX2 MAPK3 SHC1 POSTN MAPK14 MAPK1 SMAD2 NR2C2 AGTR1 SMAD4 FBN1 FLNA FBN2 FBN3 TGFBR1 PTF1A RELATED REGULATORY PATHWAY%WIKIPATHWAYS_20260510%WP4147%HOMO SAPIENS PTF1A related regulatory pathway HES1 RBPJL CTNNB1 PTF1A NKX6-1 FGF10 PDX1 RBPJ NOTCH1 PROX1 KAT2B MALE INFERTILITY%WIKIPATHWAYS_20260510%WP4673%HOMO SAPIENS Male infertility PEX10 EP300 BRCA2 DND1 CDK9 H3-4 SHMT1 FAT10 MSH4 NQO1 AHRR STRA8 BCL2 DAZL XRCC5 HEL-S-61p FOLH1 MTHFD1 XRCC3 POLG UBE2B CYP17A1 H4C9 CLU TRIP13 REC8 CYP26B1 AGO2 TMEM132E PMS2 XPC TNFSF6 RFC1 GNAO1 CREBBP ERCC1 ERCC2 AHR NR3A2 HLA-DRA HEL110 FAS CCNK PRDM9 SIRPG EPSTI1 RAG1 PEMT NANOS1 PRM2 PRM3 ABCB1 SPATA17 TSSK4 DDX4 DAZ4 DAZ3 VCX DAZ2 MOV10L1 H2BW1 TAS2R38 PUM2 APOB PIWIL2 PIWIL1 PIWIL4 SPO11 ETV5 HORMAD2 SLC46A1 MSMB PRMT6 PACRG MTRR TEX15 PON2 TCN2 PON1 INSR CXXC1 ABLIM1 SIRPA MTR OR2W3 MAS1L SLC16A7 P1 USP26 HMGA1 CDC42BPA MLH3 MDM2 CTCFL PSAT1 NOS2 SEMG1 BRDT SRD5A2 CHD2 THBS1 CYP1A1 MMP2 MMP9 TNF GPX1 KDM3A SOX5 NFE2L2 ATM PARP1 NOTCH SIGNALING%WIKIPATHWAYS_20260510%WP268%HOMO SAPIENS Notch signaling HES5 NOTCH3 DTX2 DTX3 JAG2 KCNJ5 MFNG DLL3 HES1 DLL4 DTX3L CREBBP KAT2A PSEN2 MAML1 RBPJL NUMB LFNG NOTCH2 NOTCH1 CTBP1 DVL1 DTX1 DVL2 APH1B DVL3 NCOR2 DTX4 HDAC2 HDAC1 CTBP2 PSEN1 RBPJ ADAM17 MAML3 KAT2B REGULATION OF TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP1449%HOMO SAPIENS Regulation of toll like receptor signaling MAP2K3 TLR4 RELA MAPK9 MAPK8 SFTPA2 IL12B MAP3K8 CISH MAPK3 IL12A MAPK14 PLK1 SOCS1 TNFAIP3 LBP TIRAP JUN PIK3CA CD14 IFNA1 IRAK2 IRAK3 MAP3K7IP1 IF1AA9 TLR1 IRAK1 IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 IFNA21 RBCK1 IKBKB NFKBIA CXCL9 CHUK TRAF6 MAPK1 IKBKG NFKB1 IFNA4 MAP2K6 IFNA7 MAPK13 IFNA6 IFNA2 IFNA8 IFNAR2 MBL2 IFNAR1 SPP1 RIPK1 IFNB1 CD40 MAP3K7 TLR8 CD80 TICAM2 PIK3R5 MAPK12 MAPK11 CASP8 FADD ZMYND11 TREM1 RNF41 PIK3CD SYK STAT1 BTK IRAK4 AKT3 TIFA MLST8 CCL5 LY96 CCL4 CCL3 MAP2K2 CXCL11 MYD88 MAP2K4 SMAD6 TLR5 TBK1 TLR9 IKBKE TICAM1 IRF3 MAPK10 IRF7 TLR7 PTPN6 TLR3 PELI1 FBXW5 TAB3 CD180 TRAFD1 SQSTM1 SIGIRR IL1B CUEDC2 TMED7 SFTPD RNF31 PELI3 SARM1 RAC1 PIK3R3 TNF PIK3R2 OTUD5 PIK3R1 IL6 TRAF3 CYLD CXCL8 NFKB2 MAP2K1 FOS 7Q11 23 DISTAL COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5401%HOMO SAPIENS 7q11 23 distal copy number variation POR MDH2 EPB41L3 ZP2 SFN ZP3 YWHAG LMNA TMEM120B SRRM3 HEL-S-102 TMEM120A RAF1 SSC4D DAPK2 STYXL1 RHBDD2 HEL163 PTPMT1 KIF1C MODULATORS OF TCR SIGNALING AND T CELL ACTIVATION%WIKIPATHWAYS_20260510%WP5072%HOMO SAPIENS Modulators of TCR signaling and T cell activation ZAP70 RELA GRAP2 MAP3K8 PLCG1 LCP2 CARD11 CUL5 RNF7 CD3G BCL10 CD3E CD3D NDUFB10 SOCS1 DGKZ LCK ARHH TNFAIP3 RASA2 PDPK1 LAT ITK CD8A SH2B3 PTPN6 REL GRB2 MAP4K1 MEF2D IKBKB NFKBIA VAV1 CHUK TRAF6 IKBKG MAP3K14 NFKB1 GNA13 DGKA TMEM222 ARIH2 PIK3R2 UBASH3A PIK3R1 RPRD1B FIBP CD5 AGO1 CDKN1B SH2D1A PRKCQ MELATONIN METABOLISM AND EFFECTS%WIKIPATHWAYS_20260510%WP3298%HOMO SAPIENS Melatonin metabolism and effects MAP2 ADRB1 CYP1B1 ASMT TRAF6 AANAT CYP1A1 NFKB1 APOE CALM1 MAOA CRY1 SIRT1 PER2 CYP2C19 GSK3B EDN1 PER1 CYP1A2 ACHE ECE1 PER3 MTNR1A MTNR1B PRKCA CSNK1D CSNK1E FOXO1 SULT1A1 CAMK2A IRAK1 CRY2 TOLL LIKE RECEPTOR SIGNALING RELATED TO MYD88%WIKIPATHWAYS_20260510%WP3858%HOMO SAPIENS Toll like receptor signaling related to MyD88 IKBKE TICAM1 IRF3 TLR4 IRF7 TLR7 RELA TLR3 REL IKBKB CHUK TRAF6 MAPK1 IKBKG IRAK4 NFKB1 RELB TRAF3 MYD88 TIRAP NFKB2 TLR8 TLR5 TICAM2 TLR1 IRAK1 TBK1 TLR9 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA%WIKIPATHWAYS_20260510%WP111%HOMO SAPIENS Electron transport chain OXPHOS system in mitochondria SCO1 NDUFA11 ATP5G1 HEL-S-271 NDUFC2 NDUFC1 SLC25A6 NDUFS8 NDUFS6 NDUFS5 SDHB NDUFS4 NDUFS3 NDUFS1 ND3 ND2 ND5 ND4 ND6 NDUFB8 NDUFB7 NDUFB10 NDUFB6 NDUFB5 NDUFB4 ATP6 NDUFB2 ATP5MC2 ATP5MC3 ATP5J NDUFB1 ATP5H HEL-S-123m UCP2 NDUFV3 NDUFV2 ATP5MG ATP5MF ATP5ME NDUFA9 DMAC2L NDUFA7 NDUFA6 NDUFA5 ATP5PB NDUFA3 NDUFA2 ND4L ATP5F1D ATP5F1E NDUFAB1 ATP5PO NDUFB9 SDHA SLC25A5 SDHC UQCRB SDHD UQCR11 UQCR10 CYB UQCRH UQCRQ UQCRC1 UQCRFS1 ND1 UQCRC2 COX7A1 SLC25A4 COX7B COX4I1 COX7A2 NDUFA10 COX6A1 NDUFA12 COX7C COX6A2 COX5A ATP5IF1 COX3 COX7A2L UCP3 COX2 SLC25A14 ATP8 NDUFB3 COX17 SLC25A27 COX8A UCP1 ZNF183 NDUFA13 COX11 SURF1 COX6B1 COXFA4 ALBUTEROL AND BUDESONIDE THERAPY FOR ASTHMA%WIKIPATHWAYS_20260510%WP5503%HOMO SAPIENS Albuterol and budesonide therapy for asthma CREB1 ADCY6 PLCB4 ADRB2 NR3C1 MYL1 MYL3 PLCB1 PLCB3 ADCY9 PRKAR1B MYL2 PLCB2 GNAS ADCY3 MYL4 PRKAR1A ADCY1 ADCY8 INTERLEUKIN 1 INDUCED ACTIVATION OF NF KB%WIKIPATHWAYS_20260510%WP3656%HOMO SAPIENS Interleukin 1 induced activation of NF kB UBE2V1 SQSTM1 TRAF6 AJUBA PRKCZ HEL-S-71 IRAK1 TIFA NFKB1 IL1A HAIR FOLLICLE DEVELOPMENT CYTODIFFERENTIATION STAGE 3 OF 3%WIKIPATHWAYS_20260510%WP2840%HOMO SAPIENS Hair follicle development cytodifferentiation stage 3 of 3 LRIG1 S100A4 KRTAP6-1 KRTAP2-4 KLK6 GSDMA KLK13 KLK14 FOXN1 KRT19 KRTAP8-1 NR3C1 CD200 CASP14 GJB6 SMAD4 IGFBP5 GPRC5D WIF1 IFNG DSC2 KITLG CTNNB1 MSX1 FOSB TCF4 CD34 GATA3 FOXQ1 SOX2 SMAD1 PERP DKK1 RUNX3 SFRP1 FST NFATC1 BMP6 JUN FOXE1 LEF1 BMPR1A DKK3 EGFR RBPJ IGF1 ZBTB16 ELANE TP63 FZD1 TCF3 GTPBP4 BMP4 GAS1 ATL1 DKK4 NFKB1 SOSTDC1 CD133 CTGF EGR2 NOTCH2 SOX9 NOTCH1 HR Nbla10317 HOXC12 KRTAP3-3 PHLDA1 KRTAP15-1 SPINK6 SPINK5 MSX2 ADAMTS20 DSG1 DSG4 GPR49 DLX3 FOS ADAM17 KLK5 KLK4 SARS COV 2 AND COVID 19 PATHWAY%WIKIPATHWAYS_20260510%WP4846%HOMO SAPIENS SARS CoV 2 and COVID 19 pathway CTSL FURIN ACE2 NRP1 TLR7 SCARB1 SLC6A19 ACAT1 TMPRSS2 TMPRSS4 FAMILIAL PARTIAL LIPODYSTROPHY%WIKIPATHWAYS_20260510%WP5102%HOMO SAPIENS Familial partial lipodystrophy BANF1 CIDEC MAPK9 PPARG STAT5B LMNA CIDEA NR1C1 ZMPSTE24 CEBPA FABP4 LIPE GATA3 LPL KLF2 KLF5 PLIN1 MGLL FNTA PIK3CA ICMT KLF9 PNPLA2 PRRX1 LMNB2 GATA2 INS OVERVIEW OF NANOPARTICLE EFFECTS%WIKIPATHWAYS_20260510%WP3287%HOMO SAPIENS Overview of nanoparticle effects LAMA3 BCL2 TNF IL6 HMOX1 NFRKB PTGS2 COL4A1 PTGS1 CRP CXCL8 BAX PIK3CD CCND3 AKT3 APOE AND MIR 146 IN INFLAMMATION AND ATHEROSCLEROSIS%WIKIPATHWAYS_20260510%WP3926%HOMO SAPIENS ApoE and miR 146 in inflammation and atherosclerosis APOE SPI1 NFKB2 TLR4 RELA TRAF6 IRAK1 METABOLISM OF TETRAHYDROCANNABINOL THC %WIKIPATHWAYS_20260510%WP4174%HOMO SAPIENS Metabolism of tetrahydrocannabinol THC CYP3A4 CYP2C9 GLYCOLYSIS AND GLUCONEOGENESIS%WIKIPATHWAYS_20260510%WP534%HOMO SAPIENS Glycolysis and gluconeogenesis SLC2A2 PC PKLR DLAT PCK1 GCK HK3 PGAM1 LDHB ALDOB DLD HEL-S-87p HEL-S-30 PGAM2 G6PC1 HEL-S-133P ENO1 HEL-S-68p PFKM HEL-S-162eP HEL-S-49 SLC2A4 MDH2 GOT2 PFKP SLC2A3 PFKL ENO2 ENO3 MPC1 PDHA1 HEL-S-32 MPC2 FBP2 HK2 FBP1 TCA CYCLE IN SENESCENCE%WIKIPATHWAYS_20260510%WP5050%HOMO SAPIENS TCA cycle in senescence ME1 BRAF FH PDHA1 PDP2 HEL-S-32 ME2 DISORDERS OF FOLATE METABOLISM AND TRANSPORT%WIKIPATHWAYS_20260510%WP4259%HOMO SAPIENS Disorders of folate metabolism and transport MTR SLC19A1 FOLR1 HEL-S-51e HEL-S-70p SHMT1 TYMS MTHFS MTHFD2L FTCD MTHFD1 MTHFD2 SLC46A1 DHFR IRON SULFUR CLUSTER BIOGENESIS%WIKIPATHWAYS_20260510%WP5152%HOMO SAPIENS Iron sulfur cluster biogenesis FDX1 FDXR HSCB CIAO2B NFU1 FXN NUBP1 NUBP2 ISCU NARF LYRM4 ABCB7 PATHWAYS OF NUCLEIC ACID METABOLISM AND INNATE IMMUNE SENSING%WIKIPATHWAYS_20260510%WP4705%HOMO SAPIENS Pathways of nucleic acid metabolism and innate immune sensing MITA IRF3 MAVS RIGI IFNB1 RNASEH2C RNASEH2B RNASEH2A RNASET2 ADAR TREX1 RNASEL CGAS OAS1 IFIH1 MITOCHONDRIAL COMPLEX I ASSEMBLY MODEL OXPHOS SYSTEM%WIKIPATHWAYS_20260510%WP4324%HOMO SAPIENS Mitochondrial complex I assembly model OXPHOS system NDUFC2 NDUFC1 NDUFS6 NDUFS5 NDUFS4 NDUFS3 NDUFS1 ND2 ND5 ND4 ND6 NDUFB8 NDUFB7 TMEM186 NDUFB10 C3orf60 NDUFB6 TMEM126B NDUFB5 DMAC1 NDUFB4 NDUFB11 DMAC2 NDUFB2 TMEM70 COA1 NDUFAF6 NDUFB1 NDUFAF4 NDUFV3 NDUFV2 NDUFA7 NDUFA6 NDUFA5 NDUFA3 NDUFA2 ND4L NDUFAB1 NDUFB9 NUBPL ND1 ACAD9 ECSIT TIMMDC1 NDUFA10 NDUFA12 NDUFAF2 NDUFAF1 NDUFB3 ZNF183 NDUFA13 TYPE III INTERFERON SIGNALING%WIKIPATHWAYS_20260510%WP2113%HOMO SAPIENS Type III interferon signaling IRF9 JAK1 STAT1 IF1IB1 IFNL2 IL10RB TYK2 IFNL3 STAT2 IFNLR1 MIRNA DEGRADING ENZYMES%WIKIPATHWAYS_20260510%WP4316%HOMO SAPIENS miRNA degrading enzymes XRN1 EXOSC4 PNPT1 P38 MAPK SIGNALING%WIKIPATHWAYS_20260510%WP400%HOMO SAPIENS p38 MAPK signaling CREB1 RASGRF1 MAX MAPKAPK2 GRB2 SMIM40 MEF2D MAPKAPK5 RPS6KA5 MAP3K1 STAT1 TRADD MAPK14 MYC RAC1 MAP2K6 HRAS TGFBR1 CDC42 HMGN1 TRAF2 RIPK1 MAP2K4 SHC1 MAP3K7 DDIT3 MAP3K5 HEL-S-102 ATF2 LACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260510%WP5303%HOMO SAPIENS Lacto series sphingolipid metabolism FUT2 FUT3 B3GNT5 B3GALT1 FUT1 B3GALT2 TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP75%HOMO SAPIENS Toll like receptor signaling MAP2K3 TLR4 MAPK12 MAPK11 CASP8 RELA FADD MAPK9 MAPK8 IL12B MAP3K8 MAPK3 IL12A STAT1 MAPK14 IRAK4 AKT3 CCL5 LY96 CCL4 CCL3 MAP2K2 CXCL11 LBP MYD88 TIRAP MAP2K4 JUN TLR5 CD14 IFNA1 MAP3K7IP1 TLR1 IF1AA9 IRAK1 TBK1 TLR9 IKBKE IFNA13 TICAM1 IFNA14 IRF3 MAPK10 NFKBIB IFNA16 IRF7 TLR7 IFNA17 TLR3 IFNA10 IFNA21 TAB3 IKBKB IL1B NFKBIA CXCL9 CHUK TRAF6 MAPK1 IKBKG RAC1 IFNA4 NFKB1 IFNA7 MAP2K6 MAPK13 IFNA6 IFNA2 IFNA8 IFNAR2 TNF IL6 TRAF3 IFNAR1 SPP1 RIPK1 IFNB1 CD40 CXCL8 MAP3K7 TLR8 CD80 TICAM2 MAP2K1 FOS LEUKOTRIENE METABOLIC PATHWAY%WIKIPATHWAYS_20260510%WP5171%HOMO SAPIENS Leukotriene metabolic pathway PTGR1 ALOX5 DECR2 DPEP2 CYP4F3 ABCC1 DECR1 ALOX5AP LTC4S EBSTEIN BARR VIRUS LMP1 SIGNALING%WIKIPATHWAYS_20260510%WP262%HOMO SAPIENS Ebstein Barr virus LMP1 signaling TNF RELA MAPK8 IFNB1 CXCL8 TRAF1 NFKB2 IKBKB NFKBIA MAP3K7 CHUK TRADD TRAF6 PDLIM7 MAPK1 CCL20 IKBKG MAP3K14 NFKB1 IRAK1 CCL5 UDP DERIVED SUGARS SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260510%WP5394%HOMO SAPIENS UDP derived sugars synthesis in fibroblasts GCK UGDH PGM3 UXS1 HK3 GFPT1 HK2 DIET DEPENDENT TRIMETHYLAMINE TRIMETHYLAMINE N OXIDE METABOLISM %WIKIPATHWAYS_20260510%WP5219%HOMO SAPIENS Diet dependent trimethylamine trimethylamine N oxide metabolism ALDH7A1 SLC44A1 CHDH PURINERGIC SIGNALING%WIKIPATHWAYS_20260510%WP4900%HOMO SAPIENS Purinergic signaling GNAZ GNAI1 GNA11 PANX1 GNAO1 LPAR4 P2RY13 GNAS P2RY11 P2RY1 P2RY8 GNAT2 GNAT3 GNAT1 P2RY10 P2RY14 P2RX7 P2RX6 P2RX5 P2RX4 ADORA2A P2RX3 P2RX2 P2RX1 P2RY6 P2RY4 GNAI3 ADORA2B P2RY2 TCA CYCLE AKA KREBS OR CITRIC ACID CYCLE %WIKIPATHWAYS_20260510%WP78%HOMO SAPIENS TCA cycle aka Krebs or citric acid cycle OGDH SUCLG2 MDH2 SDHC SDHD SUCLA2 SUCLG1 SDHB ACO2 IDH3B DLD FH SDHA CS MITOCHONDRIAL BETA OXIDATION%WIKIPATHWAYS_20260510%WP5241%HOMO SAPIENS Mitochondrial beta oxidation ACSL3 ACADL EHHADH HSD17B10 ACADSB DECR1 ECHS1 GLYCOSAMINOGLYCAN DEGRADATION%WIKIPATHWAYS_20260510%WP4815%HOMO SAPIENS Glycosaminoglycan degradation GUSB HEXB HEXA HGSNAT HPSE2 IDUA GNS SGSH GALNS HYAL2 HYAL4 GLB1 HPSE MAPK SIGNALING%WIKIPATHWAYS_20260510%WP382%HOMO SAPIENS MAPK signaling MAPK8IP2 DUSP3 MAP2K3 MAP2K5 RELA CACNA1H PTPN5 MAPK9 MAPK8 IL1R1 IL1A MAP3K8 MAPK3 TGFB1 JUND DUSP10 BRAF MAPK14 FGF2 FGF7 FGF8 FGF9 JUN FGF20 CD14 FGF23 FGF22 MAP3K7IP1 FGF21 HEL-S-102 STK4 FLNA FGF16 FGF14 FGF18 FGF13 FGF12 FGF10 FGF8A RAC3 RRAS2 FGF7B FGF7A FGF6B CDC42 CACNA1I FGF5C RAP1A MAP3K7 SMIM40 CACNG2 MYC AKT3 PPP3CA HRAS RASGRF2 TGFBR1 MAP2K2 PLA2G4F PLA2G4D PLA2G4E PLA2G4B PLA2G4C RASA2 NLK NFATC1 SOS1 MAPK8IP1 SOS2 EGFR CACNA2D1 NTRK1 LRRK2 NTRK2 KRAS GRB2 FGFR4 FGFR3 FGFR2 FGFR1 IL1B MAPK7 NTF3 ARAF RPS6KA5 RAC1 BDNF NRAS PAK1 GADD45A NF1 HSPA2 RASGRF1 CDC25B MAPKAPK3 MAPKAPK2 DUSP2 PRKACG NFATC3 CACNA1G RPS6KA4 ATF2 MAP3K13 MAP3K12 MEF2C MAPK8IP3 DUSP8 DUSP9 DUSP7 RAPGEF2 MAP3K11 TAOK3 TAOK2 DUSP16 PPM1B pk PPP5C MAX IKBKB LAMTOR3 MAPKAPK5 MAP3K1 CHUK RRAS TRAF6 MAPK1 IKBKG RAF1 MAP3K14 NFKB1 MAP2K6 MAPK13 TRAF2 RELB NGF RASGRP4 RASGRP3 PRKCA IL1R2 CACNB1 TNFRSF1A CACNB3 RPS6KA3 CACNA1B CACNA1A MAPK12 MAPK11 CACNA1C TNFSF6 CACNA1S GNG12 PPP3R2 FAS CACNA2D3 CACNA2D2 CACNA2D4 CACNB4 CACNA1F CACNG6 CACNG7 CACNG8 ARRB2 CACNG1 CACNG3 CACNG4 CACNG5 CRKL DUSP4 MAP2K4 DDIT3 CRK HEL-S-103 FLNB EGF MAPK10 PDGFA MAP3K2 MAP4K1 MAP4K2 PPP3CC NTF4 MAP4K3 HEL-S-72p ATF4 ECSIT PPP3R1 TNF MAP3K6 TGFBR2 NFKB2 HEL-S-31 CASP3 MAP3K5 TAOK1 MAP2K1 FOS OXIDATION BY CYTOCHROME P450%WIKIPATHWAYS_20260510%WP43%HOMO SAPIENS Oxidation by cytochrome P450 CYP2A13 CYP2F1 CYP4B1 CYP1B1 CYP11A1 CYP2W1 CYP20A1 POR CYP7A1 CYP8B1 CYP4F2 CYP4A22 CYP4F12 CYP7B1 CYP27A1 CYP4Z1 CYP3A7 CYP2U1 CYP4F22 CYP2C18 CYB5R1 CYB5R4 CYP2B6 CYP4X1 CYB5B CYP27B1 CYP24A1 CYP17A1 CYP46A1 CYP2J2 CYP2A6 CYP4F3 CYP11B2 CYP4F11 CYP4F8 CYB5R3 CYP26A1 CYP1A1 CYP2E1 CYP27C1 CYP2S1 CYP4A11 CYP26B1 CYP4V2 CYP3A4 CYP2R1 CYP2C19 CYP2C9 CYP2C8 CYP1A2 CYP3A43 CYP2A7 CYP26C1 CYP51A1 ALPHA 6 BETA 4 SIGNALING%WIKIPATHWAYS_20260510%WP244%HOMO SAPIENS Alpha 6 beta 4 signaling LAMA3 LAMB3 LAMB2 MTOR LAMA5 LAMB1 GRB2 MAPK3 MAPK1 MAPK14 RAC1 ARHA HRAS PIK3R2 PIK3R1 PTPN11 SOS1 SHC1 ITGB4 SRC PRKCA LAMC2 IRS1 ITGA6 LAMC1 EIF4EBP1 LAMA1 DEVELOPMENT OF URETERIC DERIVED COLLECTING SYSTEM%WIKIPATHWAYS_20260510%WP5053%HOMO SAPIENS Development of ureteric derived collecting system NR1B3 RARB ANOS1 SHH GRIP1 BMPER GPC3 CRIM1 ETV4 CTDNEP1 SMO BMP4 FRAS1 FREM1 TGFB1 FREM2 SPRY1 CCND1 GDF11 BMP7 PAX2 SMAD1 SIX2 DCN RARA FST BMP2 RET BMP5 BMPR1A BMPR2 HOXD11 SIX1 GDNF CELSR1 HOXA11 ETV5 SALL1 GLI3 EYA1 MIR TARGETED GENES IN SQUAMOUS CELL%WIKIPATHWAYS_20260510%WP2006%HOMO SAPIENS miR targeted genes in squamous cell DKFZp761E1322 SH3BGRL3 POLD2 SYNE2 GAS2L1 SEC23A MAP3K8 HSD17B12 CBFB HES1 AP3D1 ARCN1 FMNL2 GALNT7 GALNT1 BET1 SPTLC1 FGF2 TNFRSF10B PRPF40A SMAD1 AP2A1 ELOVL5 FBXW11 DNAJB1 LAMC1 HEL-S-26 TPM3 ANXA2 DHX57 HOXA7 POLR2C PICALM HEL-S-30 PEDS1-UBE2V1 MRPS33 TMEM59 SIGMAR1 NRP1 GYS1 HMOX1 CUL4B AXL PPP1R7 SH3BP4 SDCBP VCAM1 ATP2A2 TUBA1A YWHAQ MET P4HA2 CPNE8 NCL VEZT PWP1 CIAO2A FNDC3B FNDC3A UBE2J1 COMMD9 ATP6V1C1 HMGA1 MOV10 RHEB ANP32B MAGT1 TMED7 PNP PDLIM7 GOLGA7 CSDE1 THBS1 PXDN ATP6V0E1 PISD MPZL1 RAB34 RNP24 AKAP8 POM121 TGFBR2 NEDD4 ADIPOR2 RTN4 LAMTOR5 E2F3 MRPL20 POGLUT3 ATP6V1F SLC38A1 RARS1 TPM1 NF2 TBCA PTMAP7 ARF4 SLC12A2 SRSF9 TRAM1 TMED10 RAI14 ADAR GFPT1 SLC4A10 MRC2 CTDSP1 TMEM43 SPCS3 CHMP2A SRPRB NCRNAS INVOLVED IN STAT3 SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260510%WP4337%HOMO SAPIENS ncRNAs involved in STAT3 signaling in hepatocellular carcinoma JAK1 STAT3 SOX4 IL6 IL6ST RELA IL11 IL11RA JAK3 NFKB1 IL6R AGE RAGE PATHWAY%WIKIPATHWAYS_20260510%WP2324%HOMO SAPIENS AGE RAGE pathway CASP8 RELA PRKCZ NCF1 MAPK9 MAPK8 MAPK3 STAT5B STAT1 MAPK14 IRAK4 SMAD2 AGER CYCS ARHA SP1 INHBB DDOST HEL-S-44 HIF1A HEL70 MYD88 TIRAP EZR JUN SHC1 SRC EGFR FOXO1 ATF2 INSR STAT3 MMP7 NOS2 ALPL FOXO4 IKBKB MMP14 NFKBIA MSR1 CHUK MAPK1 RAC1 RAF1 ROCK1 MMP2 NFKB1 MMP9 CDC42 CASP9 PRKCB PRKCA CASP3 IRS1 MAP2K1 INS MIRNA ROLE IN IMMUNE RESPONSE IN SEPSIS%WIKIPATHWAYS_20260510%WP4329%HOMO SAPIENS miRNA role in immune response in sepsis TLR4 IRF7 TLR7 RELA ELANE REL MAPK8 IL10 IL1A IKBKB NFKBIA IRF1 CHUK TRAF6 MAPK14 IKBKG IRAK4 NFKB1 CCL4 CCL3 TNF VCAM1 RELB IL6 LCN2 TRAF3 MYD88 CXCL8 NFKB2 MAP3K7 TLR8 MAP3K7IP1 IRAK1 BDNF TRKB SIGNALING%WIKIPATHWAYS_20260510%WP3676%HOMO SAPIENS BDNF TrkB signaling CREB1 MTOR GAB2 ARC RHEB KRAS GRB2 PLCG1 RPS6KB1 BRAF MAPK1 HRAS BDNF TSC2 NRAS TSC1 RPS6KA1 EEF2K TRPC6 TRPC3 SOS1 SHC1 HOMER1 GRIN1 DLG4 MAP2K1 ADCY1 EIF4EBP1 NTRK2 ATM SIGNALING%WIKIPATHWAYS_20260510%WP2516%HOMO SAPIENS ATM signaling CREB1 CHEK1 MRE11A NBN BRCA1 PIDD1 MDM2 MAPK9 RAD9A CDKN1A TP73 CCNB1 MDC1 IKBKG CDC2 CRADD CDK2 TLK1 SMC1A CASP2 RIPK1 TP53BP1 GADD45A MDM4 JUN H2AX CCNE1 ATM ATF2 RAD50 CHEK2 RAD51 PENTOSE PHOSPHATE METABOLISM%WIKIPATHWAYS_20260510%WP134%HOMO SAPIENS Pentose phosphate metabolism RPIA HEL-S-304 RPE HEL107 ANGIOGENESIS%WIKIPATHWAYS_20260510%WP1539%HOMO SAPIENS Angiogenesis PDGFRA ANGPT1 HIF1A SMAD1 TIMP3 FLT1 PLCG1 FGFR2 VEGFA PIK3CA CREBBP SRC MAPK14 MAPK1 KDR MMP9 FGF2 SPHINGOLIPID METABOLISM IN SENESCENCE%WIKIPATHWAYS_20260510%WP5121%HOMO SAPIENS Sphingolipid metabolism in senescence CDK2 SPHK1 SGMS2 MTOR S1PR5 UGCG KDSR TERT CERS2 CDKN1A PLCB1 CDK4 PRKCB RPP38 PRKCA S1PR1 RB1 MAPK1 S1PR2 SGPP1 SPTLC1 DEGS1 GLB1 WNT BETA CATENIN SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260510%WP5529%HOMO SAPIENS Wnt Beta catenin signaling and ARTD family members BTRC TNK1 CTNNB1 SKP1 APC RBX1 TNK2 DVL1 DVL2 DVL3 AXIN1 PLK1 PARP1 PARP10 GLYCOSYLATION AND RELATED CONGENITAL DEFECTS%WIKIPATHWAYS_20260510%WP4521%HOMO SAPIENS Glycosylation and related congenital defects B4GALT1 ALG11 ALG6 DPM3 GCS1 TUSC3 DPM2 MPDU1 MAGT1 MGAT2 SRD5A3 DPM1 DOLK DPAGT1 GMPPB ALG8 ALG9 ALG1 ALG2 ALG14 ALG13 ALG3 ALG12 PREGNANE X RECEPTOR PATHWAY%WIKIPATHWAYS_20260510%WP2876%HOMO SAPIENS Pregnane X receptor pathway DNAJC7 RXRA ABCC3 ABCC2 UGT1A9 ABCB1 CYP3A4 CYP2B6 CYP2C19 CYP2C9 UGT1A4 CYP4F12 UGT1A3 SRC SRPX2 NCOA1 SLCO1B1 FOXO1 CYP2A6 UGT1A1 SULT2A1 NR1i2 CYP3A7 PPARGC1A PPAR SIGNALING%WIKIPATHWAYS_20260510%WP3942%HOMO SAPIENS PPAR signaling AQP7 PCK1 UBC PPARG OLR1 HEL-S-28 NR1C2 PCK2 SLC27A1 APOA2 APOC3 NR1H3 NR1C1 CD36 DBI FABP4 CYP7A1 APOA5 CYP8B1 FABP1 RXRA CPT2 ME1 CYP4A11 EHHADH ANGPTL4 LPL PLTP CPT1C PLIN1 SLC27A4 ACSL1 UCP1 PDPK1 FADS2 CYP27A1 SCD RXRB ACOX1 SLC27A5 RXRG ARIPIPRAZOLE METABOLIC PATHWAY%WIKIPATHWAYS_20260510%WP2640%HOMO SAPIENS Aripiprazole metabolic pathway CYP3A43 GLYCEROPHOSPHOLIPID BIOSYNTHETIC PATHWAY%WIKIPATHWAYS_20260510%WP2533%HOMO SAPIENS Glycerophospholipid biosynthetic pathway GPD1 PLA2G2A PTDSS1 GNPAT CHKB CDIPT PCYT2 CEPT1 AGPS PIK3CD PGS1 GPAT2 LPIN1 CDS2 PTPMT1 IPMK CRLS1 MOGAT3 GPAT4 GPAM PEMT PIK3CA HMFN0839 PIP5K1A LPIN2 PI4K2A P53 TRANSCRIPTIONAL GENE NETWORK%WIKIPATHWAYS_20260510%WP4963%HOMO SAPIENS p53 transcriptional gene network APAF1 BBC3 E2F7 PRKAA2 MGMT SLC7A11 XPC TNFSF6 TIGAR NCF2 SFN CDKN1A PTEN TP53INP1 ULK1 ERCC5 RPTOR DEPTOR FAS MLST8 CCL2 CDK2 TSC2 TNFRSF10B TP53AIP1 ZMAT3 AKT1S1 PERP FANCC ULK2 FUCA1 XRCC5 LIF PCNA TNFRSF10D BTG2 ADORA2B IRF9 AURKA PML MTOR MSH2 PIDD1 GLS2 CCNG1 RRM2B TRAF4 PRKAB2 SMR3B PRKAB1 ACAD11 THBS1 SERPINB5 POLK SCO2 ADGRB1 CX3CL1 DRAM1 DDB2 RPRM SIVA1 ULBP2 SESN1 ULBP1 TNF SESN2 DDIT4 PRKAG1 PRKAG2 PRKAG3 CPT1C PRKAA1 GPX1 NOTCH1 PMAIP1 GADD45A BAX TP53I3 CCNE1 ISG15 CEREBRAL ORGANIC ACIDURIAS INCLUDING DISEASES%WIKIPATHWAYS_20260510%WP4519%HOMO SAPIENS Cerebral organic acidurias including diseases ALDH7A1 L2HGDH MDH2 D2HGDH HEL-S-5 ADHFE1 GCDH ANDROGEN BIOSYNTHESIS%WIKIPATHWAYS_20260510%WP5393%HOMO SAPIENS Androgen biosynthesis HSD11B1 HSD11B2 POR CYP3A4 AKR1C2 AKR1D1 CYP17A1 AKR1C4 HSD17B3 SRD5A2 AKR1C1 HSD17B2 HSD3B2 HSD3B1 HSD17B1 SULT2A1 HSD17B4 CYP3A7 NO CGMP PKG MEDIATED NEUROPROTECTION%WIKIPATHWAYS_20260510%WP4008%HOMO SAPIENS NO cGMP PKG mediated neuroprotection CREB1 CNGA1 RELA PDE3A NOS2 CNGB1 GUCY1A2 CAMK2G IL1B NFKBIA ACTN2 GUCY1B1 NFKB1 AKAP9 CYCS PBR IFNG BCL2 CALM1 TNF CNGA3 CNGA4 CNGB3 BAD NEFL CASP9 CAMK2D GRIN2B NPPB GRIN1 DLG4 CAMK2A NPPA PDE2A RESOLVIN E1 AND RESOLVIN D1 SIGNALING DECREASE INFLAMMATION%WIKIPATHWAYS_20260510%WP5191%HOMO SAPIENS Resolvin E1 and resolvin D1 signaling decrease inflammation PIK3CA EPHB2 PIK3CD LTB4R MTOR CMKLR1 FPR2 GRK1 PROGERIA ASSOCIATED LIPODYSTROPHY%WIKIPATHWAYS_20260510%WP5103%HOMO SAPIENS Progeria associated lipodystrophy RECQL MUCL3 SPRTN BANF1 PPARG KCNJ6 FNTA TGFB1 WRN ICMT FFAR3 LMNA SMAD2 SMAD4 LMNB2 FBN1 PARP1 INS ZMPSTE24 22Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP4657%HOMO SAPIENS 22q11 2 copy number variation syndrome RBX1 NKX2-5 SHOC2 HES1 GLUD1 PAX3 PLK1 BCL2 VWF FGF8 GP9 SERPIND1 CLDN3 P2RX6 FOXC1 CDC45 EMC10 CLDN1 FGF10 UFD1L H4C9 RAF1 CYP26A1 CDC42 SLC2A4 MED15 PRODH DRD2 TSKS CYP26B1 HIRA ZDHHC8 RCC1 C22orf39 HIRIP3 THAP7 TSSK2 RTL10 NPRL2 HAND2 TRMT2A ESS2 KLHL22 DGCR8 GP5 SNAP29 DROSHA LRRC74B FOXC2 SEPT8 MRPL40 RAN DGCR6L TNPO1 SCARF2 DGCR2 CYP26C1 GP1BB C16orf35 GSC2 SLC7A4 GNB1L NCOR1 DEPDC5 CCDC188 ARVCF RANBP1 ZNF74 PARK2 RELN HEL-S-80p HDAC3 RORC HEL25 GBX2 PITX2 CRKL RTN4R CLTCL1 EGFR PAK4 SEPT5 SHH FGFR2 FOXA2 FGFR1 ASF1A GP1BA RTN4 ALDH1A2 SREBF2 TXNRD2 CLDN5 SLC25A1 CDH15 ACTA2 TBX1 POLR2A INTEGRATIVE ANALYSIS OF TREG GLIAL INTERACTIONS %WIKIPATHWAYS_20260510%WP5561%HOMO SAPIENS Integrative Analysis of Treg Glial Interactions HEXB OLIG2 TLR4 IKZF2 CCN3 IL2RG NKX6-2 KLRG1 JAK3 MCAM TMEM119 OLIG1 IL10 FOXO3A JAK1 IL12A STAT5B TGFB1 MOG STAT1 IGF1R MAPK14 SMAD2 IL2 HTR7 STAT4 TYK2 IL12RB1 IL10RB FOXP3 IL10RA TGFBR1 PDGFRA IFNG NKX6-1 NKX2-2 CXCL12 SOCS3 IL2RB MYD88 AREG IL4 TNFRSF1B IL2RA ITGB3 EGFR FOXO1 CSPG4 ITGAV IGF1 CNP AIF1 STAT3 CD68 SIRPA CTLA4 CCR8 TGFBR3 PDCD1 CCR6 PDGFA NOS2 SSTR2 FAM20C GSDMD ROS1 CD44 FOXO4 CCL1 IL1B CD47 CXCL1 CCL20 RAC1 IL33 ITGA2 APOD NFKB1 IL18 MMP9 MBP CDC42 TNF TGFBR2 IL6 OSM SPP1 NLRP3 SOX9 VEGFA NFKB2 CD80 EBI3 CX3CR1 DNA REPLICATION%WIKIPATHWAYS_20260510%WP466%HOMO SAPIENS DNA replication POLD2 POLE RFC3 RFC4 RFC1 RPA4 RFC2 UBC POLA2 PRIM1 GMNN POLD3 ORC6 ORC3 ORC2 CDT1 RPA1 CDC6 POLA1 POLE2 RPA3 CDK2 MCM7 ORC1L MCM10 DBF4 MCM3 MCM5 MCM6 MCM2 PCNA CDC45 PRIM2 POLD4 APOPTOSIS REGULATION BY PARATHYROID HORMONE RELATED PROTEIN%WIKIPATHWAYS_20260510%WP3872%HOMO SAPIENS Apoptosis regulation by parathyroid hormone related protein BCL2 BCL2L2 MCL1 PTHLH BAK1 BCL2A1 BCL2L1 GSK3A BOK BCL2L12 BCL2L14 GSK3B BAX ITGB4 BCL2L13 BCL2L10 ITGA6 MYC AKT3 AGE RELATED MACULAR DEGENERATION%WIKIPATHWAYS_20260510%WP5526%HOMO SAPIENS Age related macular degeneration MTOR PRKAA2 PARP2 SIRT1 PRKAG1 PRKAG2 PRKAA1 PRKAG3 PMAIP1 MAPK3 PRKAB2 RPTOR RPS6KB1 PRKAB1 HEL-S-32 MLST8 PPARGC1A CONSTITUTIVE ANDROSTANE RECEPTOR PATHWAY%WIKIPATHWAYS_20260510%WP2875%HOMO SAPIENS Constitutive androstane receptor pathway DNAJC7 CYP2B6 PTPA UGT1A4 UGT1A3 NCOA1 CYP2A6 UGT1A1 SP1 RXRA CYP4A11 SMC1A ABCC3 EHHADH UGT1A9 ABCC2 ABCB1 CYP3A4 CYP2C19 CYP2C9 ALAS1 FOXO1 SULT1A1 SULT2A1 NCOA6 NR1I3 PPARGC1A AXON GUIDANCE%WIKIPATHWAYS_20260510%WP5289%HOMO SAPIENS Axon guidance EPHB1 NRP1 SEMA3A PLXNA1 PRKCZ PARD6A SEMA5B ROBO3 DPYSL5 UNC5D HEL-S-28 SEMA7A EFNB1 ABLIM3 LRIG2 SRGAP2 TRPC1 NTNG2 NGL1 CXCR4 HRAS NTN3 L1CAM CXCL12 NCK1 MET PDPK1 EPHA2 WNT4 HEL-S-15 SRC ROBO2 RYK BMPR2 ROBO1 RGMA FES GNAI1 SLIT1 ITGB1 FYN SLIT3 SLIT2 SHH RHOD PTCH1 BOC CDK5 FZD3 RRAS MAPK1 RAC1 RAF1 ROCK1 CDC42 gdf7 MYL12B EFNA1 PARD3 GSK3B PRKCA ARHGEF12 DCC NITRIC OXIDE METABOLISM IN CYSTIC FIBROSIS%WIKIPATHWAYS_20260510%WP4947%HOMO SAPIENS Nitric oxide metabolism in cystic fibrosis PRMT1 HEL-S-277 PRMT7 NOS2 PRMT2 PRMT3 PRMT6 CARM1 AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20260510%WP521%HOMO SAPIENS Amino acid conjugation of benzoic acid ACSS2 GATF-C GLYATL2 CANCER IMMUNOTHERAPY BY CTLA4 BLOCKADE%WIKIPATHWAYS_20260510%WP4582%HOMO SAPIENS Cancer immunotherapy by CTLA4 blockade PPP2CA PIK3CA PIK3R3 PIK3R2 PIK3CD CTLA4 PIK3R1 PTPN6 CD80 HLA-DRB1 PTPN11 CILIOPATHIES%WIKIPATHWAYS_20260510%WP4803%HOMO SAPIENS Ciliopathies TULP1 CEP164 ALMS1 DYNC2I2 C2CD3 TRAF3IP1 CEP19 IFT172 GLI3 IFT52 RP1L1 DNAJB13 TCTN3 TCTN2 TMEM107 TCTN1 ZIC2 CNGA1 NEK1 BBS9 BBS7 CFAP418 CFAP410 PKD1 IFT57 RP2 MAK CC2D2A EFHC1 BBS5 CNGB1 BBS4 SDCCAG8 DYNC2H1 CRX OFD1 PKD1L1 PKHD1 SMO INTU IFT140 PDE6D NPHP3 HEL-S-296 USP9X IFT80 PCARE RPGRIP1L GPR161 DCDC2 WDR35 CEP41 LZTFL1 TRIM32 BBS10 PLK4 IFT43 NEK8 EVC BBS12 IFT81 TMEM216 CCDC41 WDPCP BBIP1 CEP104 SUFU RSPH9 KIF7 ARL6 ARL3 DYNLT2B DYNC2LI1 ARL13B RSPH3 TMEM67 RAB23 INPP5E CEP290 KIAA0753 PIBF1 IQCB1 EVC2 BBS2 BBS1 PIK3R4 SCLT1 CPLANE1 TMEM231 TTC8 TMEM17 MKS1 IFT27 B9D1 CCDC40 CLUAP1 TMEM138 RSPH1 ANKS3 NPHP1 INVS SPAG1 TMEM237 UNC119 B9D2 ODAD1 ODAD3 ODAD4 CCDC28B MCIDAS TBC1D32 NEK2 XPNPEP3 DNAAF3 DNAAF2 DNAAF6 FAM161A CCNQ CCNO DRC1 AK7 CEP78 DNAAF19 ARL2BP DNAL1 DNAAF11 HYDIN FLCN CCDC39 DNAI2 CFAP52 TOPORS RP1 NME9 WDR51B ZMYND10 KIZ CFAP53 KATNIP DNAH6 CFAP298 POC1A RAB28 DNAI1 TUB DYX1C1 ADCY6 RPGRIP1 TTLL5 HYLS1 ATXN10 OCRL ZNF423 AHI-1 NEK9 NME7 CENPF METHIONINE METABOLISM LEADING TO SULFUR AMINO ACIDS AND RELATED DISORDERS%WIKIPATHWAYS_20260510%WP4292%HOMO SAPIENS Methionine metabolism leading to sulfur amino acids and related disorders pcap CBS MAT1A HEL-S-182mP MTR CDO1 ADK CTH HEL-S-61p PI3K AKT SIGNALING%WIKIPATHWAYS_20260510%WP4172%HOMO SAPIENS PI3K Akt signaling CREB1 EIF4B TLR4 PHLPP1 ANGPT4 CSF1 PRKAA2 RELA IL2RG JAK3 PKN3 PKN2 PKN1 MAPK3 PPP2R2A PPP2R1B PPP2R1A IL2 PPP2R5B IGF2 PPP2R5A PPP2R5D PPP2R3B FGF2 XB BCL2 PPP2R3A FGF7 PPP2R2C FGF8 PPP2R2B FGF9 F2R PIK3CA FGF20 TNC VEGFC IFNA1 FGF23 FGF22 FGF21 IGF1 FGF14 FGF18 CSF3 FGF13 PCK1 IL7 FGF12 FGF10 FGF8A ITGA1 FGF7B FGF7A PRLR FGF6B VEGFB GH1 OSM SGK1 FGF5C PRL GYS1 CDKN1A FLT1 FLT3 ITGA4 FLT4 PTEN FLT3LG PIK3CD IGF1R RPTOR THBS2 COL9A1 CCND1 MYC AKT3 COL9A3 KDR MLST8 HRAS IL6R PDGFRA MAP2K2 ANGPT2 TSC2 TSC1 ANGPT1 CD19 IL3 IL2RB KIT SOS1 COL9A2 SOS2 IL4 MET EPHA2 CSF1R IL2RA EGFR ITGB3 ITGA6 ITGAV NTRK1 NGFR NTRK2 INSR MTOR BRCA1 RHEB MDM2 PPP2R5E KRAS GRB2 PPP2R5C FGFR4 COL4A2 FGFR3 FGFR2 FGFR1 NTF3 HEL-S-125m THBS1 RAC1 ITGA2 ITGB7 PIK3R3 PIK3R2 BDNF PIK3R1 NRAS TCL1B BAD TCL1A PHLPP2 CSHL1 GHB3 ITGB4 CCND3 CDKN1B CCNE1 PPP2R3C PPP2R2D CCND2 CCNE2 GYS2 GHR OSMR COL6A1 CDC37 PPP2CA CDK2 VWF RBL2 KPG_010 LAMC1 ATF2 IF1AA9 ITGB5 ITGB8 CSF3R ITGA7 ITGA2B IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 IFNA21 CDK6 HSP90AB1 CDK4 IKBKB CHUK LPAR2 MAPK1 LPAR3 IKBKG LPAR4 RAF1 IFNA4 NFKB1 IFNA7 IFNA6 CHRM2 IFNA2 IFNA8 CHRM1 IFNAR2 VEGFD IBSP IFNAR1 SPP1 COL4A1 COL4A4 IFNB1 GHB2 COL4A3 COL4A6 NGF COL4A5 COL1A1 COL2A1 PRKCA IL7R LAMC2 IRS1 INS PIK3R5 LAMA1 LAMA4 MCL1 LAMA3 LAMB3 LAMB2 LAMB4 LAMB1 RELN BCL2L11 TNFSF6 BCL2L1 VTN GNG12 FOXO3A GNG11 GNG13 JAK1 SYK RPS6 RPS6KB1 RPS6KB2 PCK2 G6PC1 GNB2 G6PC2 G6PC3 GNB1 GNB4 GNB3 EPO GNB5 EPOR KITLG IL3RA ITGB6 GNGT1 COL1A2 PDPK1 TGFA EIF4EBP1 EGF GNG3 ITGB1 PDGFD LAMA5 GNG2 PDGFC HGF GNG5 PDGFA CSH2 GNG4 EIF4E1B COL6A6 GNG7 COL6A5 GNG8 ATF6B CREB3L3 CREB3L4 CREB3L2 GNGT2 NTF4 COMP CREB3 TNR PIK3AP1 CREB5 ATF4 CHAD STK11 DDIT4 IL6 EFNA5 GNG10 EFNA4 EFNA1 PRKAA1 EFNA3 THBS4 THBS3 EFNA2 GSK3B EIF4E LPAR1 VEGFA CASP9 SGK2 MAP2K1 MYB ANGIOTENSIN II RECEPTOR TYPE 1 PATHWAY%WIKIPATHWAYS_20260510%WP5036%HOMO SAPIENS Angiotensin II receptor type 1 pathway TGFBR2 ACE2 CTGF PDGFD HIF1A COL1A2 PTPN11 MGRA COL1A1 TGFB1 JUND RRAS IL6ST IL11 MAPK1 IL11RA AGTR1 SMAD4 RAF1 ACTA2 MAP2K6 NOX4 TGFBR1 SP1 TLR4 SIGNALING AND TOLERANCE%WIKIPATHWAYS_20260510%WP3851%HOMO SAPIENS TLR4 signaling and tolerance INPP5D IKBKE TICAM1 IRF3 TLR4 IRF7 IKBKB NFKBIA CHUK TRAF6 IKBKG IRAK4 NFKB1 TNF IL6 TRAF3 MYD88 RIPK1 TIRAP IFNB1 CXCL8 MAP3K7 TRAM1 IRAK3 MAP3K7IP1 IRAK1 TBK1 ERK PATHWAY IN HUNTINGTON 39 S DISEASE%WIKIPATHWAYS_20260510%WP3853%HOMO SAPIENS ERK pathway in Huntington 39 s disease CREB1 MAP2K2 EGF BDNF MAPK3 HTT RPS6KA5 CASP3 EGFR MAPK1 RAF1 MAP2K1 NTRK2 HRAS FARNESOID X RECEPTOR PATHWAY%WIKIPATHWAYS_20260510%WP2879%HOMO SAPIENS Farnesoid X receptor pathway CYP7A1 CYP8B1 RXRA FGF8A NR0B2 CYP3A4 FKBP5 ABCB4 BAAT ABCB11 NR1H4 SLC27A5 SULT2A1 SLCO2B1 UGT2B4 PPARGC1A IP6K3 NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN NOD PATHWAY%WIKIPATHWAYS_20260510%WP1433%HOMO SAPIENS Nucleotide binding oligomerization domain NOD pathway RIPK2 DUOX2 RELA CASP8 PRDM1 NOD1 NLRC4 MEFV AAMP CARD8 CARD9 CARD6 NLRP12 IKBKB ACAP1 IL1B NFKBIA NLRP10 CASP5 CHUK NLRP7 NLRP2 IKBKG RAC1 NLRP1 IL18 PYCARD COPS6 NLRP3 NDUFA13 CASP9 ERBIN NAIP AIM2 NOD2 7Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP4932%HOMO SAPIENS 7q11 23 copy number variation syndrome BAZ1B ATP5G1 GTF2I HEL-S-271 GRIP1 ACACA SMARCA5 DEK USF1 RFC2 CHTF18 HDAC3 MAPK3 ULK1 DLD ACACB BTK SNAP25 MYC FAS FBN1 STX1A ATP6 ATP5MC2 NUP62 ATP5MC3 EIF2A CTNNB1 CDKN1C HDAC6 VAMP2 HEL-S-123m MYBBP1A CLTC CLDN3 TSG101 ATP5PB NRG1 HEL-S-15 ATPAF2 HDAC2 PCNA ATP5F1D ATP5F1E RB1 SF3B1 ATP5PO MLXIPL BRD4 CLDN1 UBE2L6 PKLR OGDH HMGA1 CLDN4 GRB2 DDX21 SQSTM1 BCL7B BUD23 VPS9D1 LAT2 UBE2E3 VPS37C UBE2E1 VPS37D VPS37A VPS37B FZD9 CLIP2 METTL27 ATF4 HEL-S-162eP FKBP6 VPS28 ATPAF1 TRIM50 HOXC8 UBIAD1 FBLN2 FBLN5 MVB12A EIF4H LIMK1 CLASP2 ABHD11 PRKG1 TMEM270 TBL2 GTF2IRD1 ATP8 H2AX CLDN5 MYO1C CLASP1 HSPA2 HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CARCINOMA PATHWAY%WIKIPATHWAYS_20260510%WP4206%HOMO SAPIENS Hereditary leiomyomatosis and renal cell carcinoma pathway HIF1A PRKAG1 ACACA PRKAA1 VEGFA RPS6 NFE2L2 SLC11A2 ACACB PRKAB1 EGLN1 PDHA2 PDHA1 HEL-S-133P KEAP1 MAMMARY GLAND DEVELOPMENT EMBRYONIC DEVELOPMENT STAGE 1 OF 4%WIKIPATHWAYS_20260510%WP2813%HOMO SAPIENS Mammary gland development embryonic development stage 1 of 4 TNF ITGB1 ERBB4 CLDN4 SFRP1 TERT ALPL TGFB1 NRG3 CCND1 ITGA6 ZEB2 MYC ARACHIDONATE EPOXYGENASE EPOXIDE HYDROLASE%WIKIPATHWAYS_20260510%WP678%HOMO SAPIENS Arachidonate epoxygenase epoxide hydrolase COX8A CYP2J2 EPHX2 COX5A HEL-S-22 CYP2C9 CYP2C8 STATIN INHIBITION OF CHOLESTEROL PRODUCTION%WIKIPATHWAYS_20260510%WP430%HOMO SAPIENS Statin inhibition of cholesterol production APOA2 APOC3 APOE CYP7A1 ABCA1 APOA5 ABCG8 ABCG5 DGAT1 SCARB1 LIPC SOAT1 LPL PDIA2 APOA4 PLTP LDLR ACSS1 MTTP HMGCR APOB SQLE APOC2 FDFT1 APOC1 JAK STAT SIGNALING IN THE REGULATION OF BETA CELLS%WIKIPATHWAYS_20260510%WP5358%HOMO SAPIENS JAK STAT signaling in the regulation of beta cells SOCS2 STAT3 PRL MTOR KRAS CISH CDK4 STAT5B STAT1 RPTOR GHR AKT3 PRLR FOXM1 SOCS1 IFNGR1 MLST8 HRAS EPO IL6R EPOR GH1 IFNG NRAS IL6 SOCS3 AKT1S1 CCND3 IFNGR2 CCND2 FABP4 IN OVARIAN CANCER%WIKIPATHWAYS_20260510%WP4400%HOMO SAPIENS FABP4 in ovarian cancer FABP4 SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP %WIKIPATHWAYS_20260510%WP3391%HOMO SAPIENS Senescence associated secretory phenotype SASP H2AB1 RPS6KA3 CDC27 H2AJ ANAPC7 H3C15 RELA ANAPC5 ANAPC1 ANAPC2 CDKN1A IL1A ANAPC10 MAPK3 ANAPC11 UBE2C UBB IGFBP7 CDK2 CCNA2 JUN FZR1 CDKN2D CDKN2B CDKN2C STAT3 H3F3B H2AC19 CDKN2A UBE2D1 H2AC14 H2BC26 H2BC12L H2BC21 UBC EHMT1 CDK6 HIST1H2AB CDK4 H2AC6 H2BC17 MAPK7 H2BC12 H2BC13 H2AZ1 H2BC14 H2BC15 H4C9 MAPK1 UBE2E1 H2BC11 HIST1H2BE HIST1H4L NFKB1 H2BC9 CEBPB H2BC8 H2BC3 IL6 RPS6KA2 RPS6KA1 RPS27A H2BC1 H2AC20 CDC26 VENTX ANAPC15 C10orf104 UBE2S CXCL8 H2AX CDKN1B CDC23 H2AZ2 H3C8 FOS INTRACELLULAR TRAFFICKING PROTEINS INVOLVED IN CMT NEUROPATHY%WIKIPATHWAYS_20260510%WP4856%HOMO SAPIENS Intracellular trafficking proteins involved in CMT neuropathy RAB3B FIG4 EGR2 KIF1B RABAC1 MPZ RAB11A NEFL LRSAM1 RAB11B RAB4B HSPB8 RAB7A LITAF GDAP1 PMP22 MFN2 FGD4 SH3TC2 RAB25 MTMR2 HEL-S-102 RAB4A SBF2 HEMATOPOIETIC STEM CELL GENE REGULATION BY GABP ALPHA BETA COMPLEX%WIKIPATHWAYS_20260510%WP3657%HOMO SAPIENS Hematopoietic stem cell gene regulation by GABP alpha beta complex TERF2 BCL2 MCL1 EP300 BCL2L1 SMARCA4 GABPA FOXO3A FLT3 ETV6 CREBBP PTEN ZFX ATM DNMT3B SMAD4 GABPB1 PAFAH1B1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5409%HOMO SAPIENS PAFAH1B1 copy number variation TUBA1A NDEL1 RELN NUDC HEL-S-303 VLDLR PAFAH1B1 DYNC1H1 DCX GUT LIVER INDOLE METABOLISM %WIKIPATHWAYS_20260510%WP3627%HOMO SAPIENS Gut liver indole metabolism CYP2E1 METABOLISM OF DICHLOROETHYLENE BY CYP450%WIKIPATHWAYS_20260510%WP3666%HOMO SAPIENS Metabolism of dichloroethylene by CYP450 CYP2E1 GENES ASSOCIATED WITH THE DEVELOPMENT OF RHEUMATOID ARTHRITIS%WIKIPATHWAYS_20260510%WP5033%HOMO SAPIENS Genes associated with the development of rheumatoid arthritis CTLA4 CCR6 CD40 SLC22A4 TRAF1 MHC2TA IL2RA IL6ST FCRL3 PTPN22 HLA-DRB1 PADI4 CD244 PHF19 BLK STAT4 ITGAV NAD BIOSYNTHETIC PATHWAYS%WIKIPATHWAYS_20260510%WP3645%HOMO SAPIENS NAD biosynthetic pathways NMNAT1 IDO1 HEL-S-90n PARP2 SIRT5 TDO2 SIRT1 SIRT2 SIRT3 NAPRT BST1 NAMPT NADSYN1 TNKS PARP4 PARP1 SIRT7 TNKS2 SIRT6 SIRT4 RAC1 PAK1 P38 MMP2 PATHWAY%WIKIPATHWAYS_20260510%WP3303%HOMO SAPIENS RAC1 PAK1 p38 MMP2 pathway TNIP3 YAP1 ANGPT4 MAPK12 MAPK11 RELA MAPK9 MAPK8 MAPK3 STAT5B MAPK14 MYC HRAS ANGPT2 CTNNB1 ANGPT1 SOS1 NCK1 PXN PIK3CA SRC CRK EGFR FOXO1 EIF4EBP1 STAT3 ITGB1 MSH2 NOS2 KRAS GRB2 BIRC5 IKBKB NFKBIA CHUK MAPK1 IKBKG RAC1 MMP2 NFKB1 MAPK13 PIK3R1 NRAS PAK1 BAD GRB14 PTPN11 BAX CASP9 RS1 ANGPTL1 GRB7 ERBB2 RAD51 TNIP2 CARDIAC PROGENITOR DIFFERENTIATION%WIKIPATHWAYS_20260510%WP2406%HOMO SAPIENS Cardiac progenitor differentiation MESP1 THY1 TNNI3 NODAL SOX17 NKX2-5 TBX20 IRX4 MYLK3 TBX5 ISL1 TGFB1 PAX6 MAPK14 CXCR4 KDR IGF2 FGF2 PDGFRA MESP2 SOX2 NOG DKK1 KIT BMP1 SOX1 NRG1 POU5F1 ZFP42 ROR2 MYL2 GATA4 IGF1 MEF2C LIN28A SIRPA NCAM1 INHBA BMP4 FOXA2 SCN5A TBXT WNT3A MIXL1 NOTCH1 LIN28B MYH6 GSK3B INS CLEAR CELL RENAL CELL CARCINOMA PATHWAYS%WIKIPATHWAYS_20260510%WP4018%HOMO SAPIENS Clear cell renal cell carcinoma pathways EP300 KDM5C BAP1 EFCAB3 PBRM1 MAP2K5 SDSL PGBD5 LDHD HK3 ACACA SHMT1 FLT1 PTEN LDHB CREBBP ALDOB RPTOR DEPTOR PGM2 ACACB SSPN KDR MLST8 PLOD2 PDGFRA KSR1 TSC2 TSC1 HIF1A AKT1S1 RAPGEF5 ENO2 EGFR FASN ENO3 HEL-S-32 HK2 ACLY PKLR STAT3 MTOR RHEB PSAT1 PHGDH HEL-S-51e PSPH SQSTM1 BHLHE41 GRB10 HEL-S-87p HEL-S-30 CAMK1 HEL-S-133P ENO1 HEL-S-68p PFKM HEL-S-162eP HEL-S-49 ME1 PFKP VHL ENPP3 KCNJ2 VEGFA PFKL CEP290 SETD2 RETT SYNDROME%WIKIPATHWAYS_20260510%WP4312%HOMO SAPIENS Rett syndrome GABRA3 NCOR1 SYNE2 CDKL5 ACTL6B CHD4 KDM5B TRRAP GPS2 RHOBTB2 CECR2 SMARCA4 HIVEP2 KCNJ10 TBL1XR1 GNAO1 IMPDH2 GABBR2 BRAF SCN1A SRRM3 STXBP1 SCN8A SCN2A HDAC5 TAF1B HDAC8 TBL1X TCF4 EIF2B2 SMC1A SMARCA1 FOXG1 XAB2 HAP1 SYNGAP1 NCOR2 HTT HDAC1 GRIN2B CRK SHANK3 MEF2C PURINE METABOLISM%WIKIPATHWAYS_20260510%WP4792%HOMO SAPIENS Purine metabolism ADSL AMPD1 XDH PNP APRT DGUOK ADA IMPDH1 HPRT1 ADSS HEL-S-70p COVID 19 STRUCTURAL COVERAGE MAP%WIKIPATHWAYS_20260510%WP5145%HOMO SAPIENS COVID 19 structural coverage map MACROH2A2 MACROH2A1 ACE2 NRP1 SLC6A19 UBC NLRP12 UPF2 PARP14 IGHMBP2 UBB GDAP2 MACROD1 HEL97 MACROD2 CMTR1 AQR PAIP1 TOMM70 MAP3K7IP1 PALS1 ISG15 EUKARYOTIC TRANSCRIPTION INITIATION%WIKIPATHWAYS_20260510%WP405%HOMO SAPIENS Eukaryotic transcription initiation POLR2B POLR2G POLR2I POLR2J GTF2H2C_2 GTF2H2 GTF2H3 TAF9 POLR1A GTF2E2 POLR3B POLR1D HEL-S-28 POLR3D ERCC2 POLR3E POLR2C MNAT1 TBP TAF7 POLR3K TAF6 GTF2E1 POLR2F CDK7 POLR2H POLR2K POLR3H TAF12 TAF13 GTF2F2 CCNH TAF5 GTF2B POLR2A IMATINIB AND CHRONIC MYELOID LEUKEMIA%WIKIPATHWAYS_20260510%WP3640%HOMO SAPIENS Imatinib and chronic myeloid leukemia PDGFRA SKP2 GAB2 ABCB1 KIT GADD45A FLT1 FOXO3A CSF1R PIM1 CDKN1B PIM2 BCR LYL1 ABCG2 MYC NOP2 TRANSLATION FACTORS%WIKIPATHWAYS_20260510%WP107%HOMO SAPIENS Translation factors EIF3CL EIF4B EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B EIF2S2 EEF2 EIF2S1 EIF6 EIF4A2 EIF4G1 PAIP1 GSPT2 EEF1B2 EIF4EBP3 EIF2B3 CLUH EIF1AY EEF1G EEF1A2 ETF1 EIF2B5 EIF4H EIF2B2 EEF2K EIF5A EEF1A1 PABPC1 EIF4E EIF5B EIF1AX SUI1 EIF2AK2 EIF5 EIF4A1 EIF2AK1 EIF2S3 EIF2B1 EIF3S2 EIF4EBP1 EIF3J EIF4EBP2 EIF3S3 EIF3G DRUG INDUCTION OF BILE ACID PATHWAY%WIKIPATHWAYS_20260510%WP2289%HOMO SAPIENS Drug induction of bile acid pathway CYP7A1 ABCC3 ABCC2 ABCB1 CYP3A4 SLC51A BAAT SLC51B ABCB11 SLCO1B1 NR1H4 SULT2A1 NR1i2 NR1I3 NR1i1 GLIAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260510%WP2276%HOMO SAPIENS Glial cell differentiation CNP FREP1 HEL70 MBP GAP43 CALCIUM MEDIATED T CELL APOPTOSIS INVOLVED IN INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260510%WP5142%HOMO SAPIENS Calcium mediated T cell apoptosis involved in inclusion body myositis CD8B1 ZAP70 NFATC2 CALM1 CD8A EP300 LCK ITPRIP ATP2A1 CABIN1 PLCG1 MEF2D HDAC2 HDAC1 PPP3CC PPP3CA AMPLIFICATION AND EXPANSION OF ONCOGENIC PATHWAYS AS METASTATIC TRAITS%WIKIPATHWAYS_20260510%WP3678%HOMO SAPIENS Amplification and expansion of oncogenic pathways as metastatic traits VEGFA TCF7L2 POSTN VCAM1 SRC TCF7L1 LEF1 TNC CYTIP CXCR4 VHL NOTCH1 ACQUIRED PARTIAL LIPODYSTROPHY BARRAQUER SIMONS SYNDROME%WIKIPATHWAYS_20260510%WP5104%HOMO SAPIENS Acquired partial lipodystrophy Barraquer Simons syndrome FNTA ICMT CFD LMNA RCE1 HEL-S-62p LMNB2 ALLOGRAFT REJECTION%WIKIPATHWAYS_20260510%WP2328%HOMO SAPIENS Allograft rejection CXCL13 CASP8 PRKCZ TNFSF6 C4B_2 CSNK2A2 C2 IL13 IL12B IL10 IL1A C6 C7 IF2B1 BHMT2 C9 IL12A TGFB1 HLA-G CD55 STAT1 CD40LG HEL113 HEL-S-62p HLA-DRA IL-21 IL2 FAS FOXP3 C1QC PDGFRA IFNG TUBA1B HLA-DMB CXCL11 CXCL12 GNLY HLA-DOA HLA-DOB HLA-DMA ABCB1 IL4 IL2RA HLA-DQA2 HLA-DQA1 PECR IL17A HLA-A HLA-DRB5 GDNF HLA-DRB1 LRRK2 HLA-DPA1 HLA-DQB1 CTLA4 HLA-DPB1 HLA-B HLA-C HLA-F GABPA HLA-E CXCR5 IL1B CCL19 CXCL9 HARS1 CCL21 PRF1 AGTR1 C8A C4A TNF CD40 CXCL8 C1QA VEGFA CASP9 MICA CD80 CASP3 C1QB IL5 PHOTODYNAMIC THERAPY INDUCED UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260510%WP3613%HOMO SAPIENS Photodynamic therapy induced unfolded protein response ASNS HEL-S-99n DNAJB11 EIF2A ATF3 PPP1R15A BBC3 SULT1E1 BCL2L11 EDEM1 NARS1 DNAJC3 ERP27 DNAJB9 HEL-S-125m HEL-S-89n NFE2L2 DDIT3 UBE2E1 XBP1 TRIB3 ATF4 ERN1 ENVELOPE PROTEINS AND THEIR POTENTIAL ROLES IN EDMD PHYSIOPATHOLOGY%WIKIPATHWAYS_20260510%WP4535%HOMO SAPIENS Envelope proteins and their potential roles in EDMD physiopathology ADCY6 SYNE2 SYNE1 BANF1 KRAS GRB2 MAPK3 TGFB1 MAPK1 SMAD2 SMAD4 ARHA HRAS LBR WWTR1 LEMD3 MAP2K2 NRAS CTGF SYNE4 SYNE3 SOS1 SUN1 SOS2 YY1AP1 PLEC HEL-S-7a HEL-S-15 EMD HEL-S-61 ADCY9 MAP2K1 ADCY3 TMEM43 ADCY1 ADCY8 MONOAMINE TRANSPORT AND REGULATION%WIKIPATHWAYS_20260510%WP727%HOMO SAPIENS Monoamine transport and regulation TPH2 TDO2 FBXO32 IL1R1 SYN1 SLC5A7 IL1B AMPH DBH SLC6A1 MAPK14 STX1A TNFRSF11B SLC6A3 TNF SLC6A2 TSC2 TH RBL2 ACHE HRH3 ADORA2A NECTIN2 TGFB1I1 UNC13B ITGB3 IL2 SIGNALING%WIKIPATHWAYS_20260510%WP49%HOMO SAPIENS IL2 signaling STAT3 FYN GAB2 IL2RG JAK3 GRB2 FOXO3A CISH MAPK3 JAK1 STAT5B SYK PTK2B STAT1 RPS6 RPS6KB1 RPS6KB2 MAPK1 IL2 RAF1 HRAS MAP2K2 PIK3R1 LCK SOCS3 IL2RB CRKL PTPN11 SOS1 IL2RA SHC1 NMI MAP2K1 CBL IL11 SIGNALING%WIKIPATHWAYS_20260510%WP2332%HOMO SAPIENS IL11 signaling CREB1 STAT3 FYN YES1 RELA GRB2 PTPA RUNX2 ATF1 BIRC5 MAPK3 JAK1 IKBKB TGFB1 STAT1 CHUK RPS6 RPS6KB1 IL6ST IL11 MAPK1 IL11RA RAF1 ITGA2 TYK2 HRAS MAP2K2 BCL2 PIK3R2 PIK3R1 BGLAP IBSP RPS6KA1 SOCS3 PTPN11 PDPK1 SRC MAP2K1 PIAS1 FES INTRAFLAGELLAR TRANSPORT PROTEINS BINDING TO DYNEIN%WIKIPATHWAYS_20260510%WP4532%HOMO SAPIENS Intraflagellar transport proteins binding to dynein DYNLL2 IFT22 IFT27 DYNLT2B DYNLRB2 DYNC1LI1 DYNC2LI1 DNCL1 DYNC2H1 DYNC1I1 IFT25 DYNLT1 IFT140 DYNC1LI2 IFT80 DYNC2I2 WDR35 IFT43 IFT81 DYNC1H1 DYNLT3 IFT46 REGUCALCIN IN PROXIMAL TUBULE EPITHELIAL KIDNEY CELLS%WIKIPATHWAYS_20260510%WP4838%HOMO SAPIENS Regucalcin in proximal tubule epithelial kidney cells APAF1 MTOR CASP8 PTH TRPV5 TGFB1 BRAF MAPK1 SMAD2 SMAD4 RAF1 PDE1B TGFBR1 PPP3R1 TNFSF11 BAK1 BAX CALCA PIK3CA CASP9 MCU FFAR3 SEC16B HEL-S-41 CASP3 MAP3K5 TNFRSF1A ACTA2 MSMP EXPRESSION REGULATION IN CANCER CELLS AND ITS PRO ANGIOGENIC ROLE IN OVARIAN TUMORS%WIKIPATHWAYS_20260510%WP4397%HOMO SAPIENS MSMP expression regulation in cancer cells and its pro angiogenic role in ovarian tumors CTCF MSMP CCR2 NEUROINFLAMMATION%WIKIPATHWAYS_20260510%WP4919%HOMO SAPIENS Neuroinflammation JUN NFKBIA TLR4 MTOR CHUK RELA ASCC1 MAPK14 NOS2 COX2 MAPK8 FOS INHIBITION OF EXOSOME BIOGENESIS AND SECRETION BY MANUMYCIN A IN CRPC CELLS%WIKIPATHWAYS_20260510%WP4301%HOMO SAPIENS Inhibition of exosome biogenesis and secretion by manumycin A in CRPC cells RAB5B RAB5C NRAS HNRNPH1 KRAS HGS MAPK3 RRAS2 RAB5A ARAF RRAS BRAF PDCD6IP MAPK1 RAF1 RAB27A HRAS MAJOR RECEPTORS TARGETED BY EPINEPHRINE AND NOREPINEPHRINE%WIKIPATHWAYS_20260510%WP4589%HOMO SAPIENS Major receptors targeted by epinephrine and norepinephrine ADRA2A HEL-S-7a ADCY6 ADRA1D ADRB1 ADRB2 ADCY9 ADCY3 ADRA2C ADCY1 ADCY8 ADRA2B 2Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP5221%HOMO SAPIENS 2q11 2 copy number variation syndrome FER1L5 STARD7 SEMA4C ARID5A ASTL NEURL3 SNRNP200 KANSL3 PLXNB2 MMS19 MAPK3 CIAO2B MAPK1 DUSP2 ARHA ADRA2B ANKRD23 ZP2 COX11 COL2A1 CIAO2A ANKRD39 PARL CIAO1 ITPRIPL1 TMEM127 CNNM3 ERBB2 CNNM4 GLUCOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260510%WP5280%HOMO SAPIENS Glucocorticoid biosynthesis HSD11B1 AKR1C4 HSD11B2 CYP21A2 SRD5A2 AKR1C1 CYP11B2 CYP3A4 AKR1C2 AKR1D1 ANTIVIRAL AND ANTI INFLAMMATORY EFFECTS OF NRF2 ON SARS COV 2 PATHWAY%WIKIPATHWAYS_20260510%WP5113%HOMO SAPIENS Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway IRF3 RELA SLC7A11 HMOX1 GUCY1A2 IL12A IKBKB IL1B NFKBIA CHUK NQO1 IKBKG GUCY1B1 NFKB1 KEAP1 CCL2 TNF ACE2 RXRA IL6 CXCL8 NFE2L2 GCLC GCLM TMPRSS2 MMP3 PHASE I BIOTRANSFORMATIONS NON P450%WIKIPATHWAYS_20260510%WP136%HOMO SAPIENS Phase I biotransformations non P450 PON1 CES2 CES1 PON3 ESD LIPA PON2 HEL126 NONALCOHOLIC FATTY LIVER DISEASE%WIKIPATHWAYS_20260510%WP4396%HOMO SAPIENS Nonalcoholic fatty liver disease PRKAA2 NDUFA11 RELA COXFA4L2 NDUFC2 MAPK9 NDUFC1 MAPK8 NDUFS8 IL1A NDUFS6 NDUFS5 SDHB NDUFS4 NDUFS3 TGFB1 NDUFS1 NDUFB8 NDUFB7 NDUFB10 NDUFB6 NDUFB5 NDUFB4 NDUFB11 NDUFB2 NDUFB1 NDUFV3 NDUFV2 NDUFA9 NDUFA7 NDUFA6 NDUFA5 JUN PIK3CA NDUFA3 NDUFA2 NDUFAB1 MLXIPL SDHA SDHC UQCRB SDHD MAP3K11 UQCR11 UQCR10 NDUFC2-KCTD14 CYB COX6B2 UQCRH COX7B2 UQCRQ MLX UQCRC1 COX8C CYC1 MLXIP UQCRC2 UQCRHL IKBKB NFKB1 CDC42 TRAF2 NDUFA10 NDUFA13 IRS1 TNFRSF1A NR1H4 XBP1 INS COX4I2 BBC3 CASP8 BCL2L11 TNFSF6 GSK3A PIK3CD AKT3 FAS CYCS NR1H3 NR1C1 IL6R CCL2 VCAM1 RXRA SOCS3 ITCH DDIT3 NDUFB9 INSR PKLR EIF2S1 UQCRFS1 COX7A1 IL1B PRKAB2 PRKAB1 RAC1 CYP2E1 ATF4 LEP CEBPA COX7B PIK3R3 TNF PIK3R2 PIK3R1 COX4I1 COX7A2 IL6 ADIPOR2 COX6A1 NDUFA12 PRKAG1 COX7C COX6A2 ADIPOR1 PRKAG2 COX5A BAK1 COX3 PRKAG3 PRKAA1 COX7A2L COX2 NDUFB3 GSK3B CXCL8 COX8A ZNF183 BAX COX6B1 CASP3 MAP3K5 COXFA4 LEPR ERN1 GPCRS CLASS A RHODOPSIN LIKE%WIKIPATHWAYS_20260510%WP455%HOMO SAPIENS GPCRs class A rhodopsin like F2R FPR2 HRH3 GPER LTB4R KPG_011 CCR10 CCR1 XCR1 FPR1 CCR8 CCR7 CCR6 CCR4 CCR2 BDKRB2 SSTR2 CXCR5 BDKRB1 NPFFR2 RRH GPR174 GPR161 GPR173 GPR171 CMKLR2 GPR37L1 OR1I1 NPBWR2 OR6B1 OR2J3 OR2J2 OR2J1 RGL4 OR6A2 OXTR OR7C2 OR7C1 NPY2R GPR19 OR10J1 GPR27 NPFFR1 GPR25 GPR22 GPR39 DRD1 OR5F1 DRD2 GPR34 DRD3 PTGDR GPR31 OPRK1 GPR32 OR5V1 OR3A2 OR10H1 OR10H3 GPR45 MGRA HCRTR2 OR10H2 HCRTR1 GPR42 OR2AG1 ADORA2A CHML MTNR1B GPR52 GPR4 GPR3 GPR6 OR1C1 GPR65 GPR63 OR2D2 OR2T1 OR1A2 OR1A1 OR2C1 SUCNR1 OR5I1 MCHR1 OR2S2 HCAR3 OR1Q1 GPR83 HCAR1 OR2B3 OR2B2 NMUR2 NMUR1 F2RL1 OR7A10 OR14J1 MLNR AVPR2 PRLHR OR8D2 OR7A17 OR7A5 CCR5 OR10A4 OR1E2 OR8B8 OR2W1 HTR2B OR12D3 HTR4 OR1D5 HRH1 OR1D2 HTR6 CXCR4 OR2F2 HTR7 GPR85 ACKR2 HRH2 OR11A1 FFAR1 DRD5 ADRA2C CXCR3 HTR5A ADRA2B ADRA2A ACKR3 MC1R GPR87 GPR75 GPR37 MAS1L CXCR1 GPR68 OPN1SW OPN1MW OPN1LW OPN4 OPN3 RHO MC3R NMBR GHSR EDNRA EDNRB HTR2A HTR1E HTR1F F2RL2 HTR1D HTR1B 5HT1A CNR1 LHCGR P2RY10 P2RY14 NPY1R OR1G1 KPG_010 GRPR P2RY6 P2RY4 ADORA2B P2RY2 CCR3 OR1F1 OR2H1 CCKBR FSHR CCRL2 OR3A3 OR10A5 OR3A1 OR1E1 OR2B6 NTSR1 LPAR4 P2RY13 GPR17 P2RY11 CHRM2 OR2F1 CHRM3 CHRM1 C3AR1 CHRM4 CHRM5 OR2A4 GPR18 CMKLR1 IL8RB F2RL3 MC4R ACKR4 CX3CR1 C5AR2 PTGDR2 ADRB1 ADRB2 GPR15 P2RY1 DRD4 ADRA1D ADRA1B ADRA1A AVPR1B ADRB3 AGTR1 AGTR2 BRS3 CCKAR NPY5R OPRM1 AVPR1A SSTR3 SSTR4 FPRL2 TRHR SSTR5 OPRD1 NPY4R MC2R PTGER4 PTGFR GALR3 GALR2 PTGIR GALR1 PTGER1 PTGER2 NTSR2 PTGER3 MC5R GPR50 MTNR1A FFAR3 CNR2 FFAR2 TBXA2R