S< I>-METHYL-5-THIO-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-4361 S< i>-methyl-5-thio-α-D-ribose 1-phosphate degradation ADI1 APIP MRI1 KYAT1 ENOPH1 L-CYSTEINE DEGRADATION III%BIOCYC%PWY-5329 L-cysteine degradation III MPST GOT1-1 CISD1 L-GLUTAMATE DEGRADATION (VIA 4-AMINOBUTANOATE)%BIOCYC%PWY0-1305 L-glutamate degradation (via 4-aminobutanoate) GAD1 GAD2 GLUL ESTRADIOL BIOSYNTHESIS II%BIOCYC%PWY-7306 estradiol biosynthesis II CYP2A13;CYP2A6;CYP2A7-1 CYP19A1 DOCOSAHEXAENOATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7606 docosahexaenoate biosynthesis III (6-desaturase, mammals) FADS2 ELOVL5 EHHADH-1 ELOVL2 HSD17B12 METHYLGLYOXAL DEGRADATION VI%BIOCYC%MGLDLCTANA-PWY methylglyoxal degradation VI LDHD GLUTARYL-COA DEGRADATION%BIOCYC%PWY-5177 glutaryl-CoA degradation ACAT2 ACAT1 GCDH ECHS1 L-ASPARAGINE BIOSYNTHESIS%BIOCYC%ASPARAGINE-BIOSYNTHESIS L-asparagine biosynthesis ASNS PHYTOL DEGRADATION%BIOCYC%PWY66-389 phytol degradation ALDH3A2 PECR MENAQUINOL-4 BIOSYNTHESIS II%BIOCYC%PWY-7998 menaquinol-4 biosynthesis II UBIAD1 SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%BIOCYC%PWY-6358 superpathway of D-myo< i>-inositol (1,4,5)-trisphosphate metabolism INPP1 IPMK INPPL1 PTEN OCRL SYNJ2 INPP5B ITPKB ITPKC MINPP1 INPP5A BPNT2-1 SYNJ1 INPP5F IMPA1 IMPA2 INPP5D ITPKA INPP5J INPP5K L-CYSTEINE BIOSYNTHESIS III (FROM L-HOMOCYSTEINE)%BIOCYC%HOMOCYSDEGR-PWY L-cysteine biosynthesis III (from L-homocysteine) CBS;CBSL CTH SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo< i> biosynthesis CAD NME2 CTPS2 NME3 CTPS1 NTPCR NME5 TYMS DHODH NME1 NME6 RRM2B NME7 CMPK1 CMPK2 UMPS RRM2-1 RRM1 DUT DTYMK NME4-1 MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-8171 molybdenum cofactor biosynthesis GPHN SEROTONIN AND MELATONIN BIOSYNTHESIS%BIOCYC%PWY-6030 serotonin and melatonin biosynthesis TPH2 DDC TPH1 AANAT ASMT ZYMOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6074 zymosterol biosynthesis NSDHL HSD17B7 LBR TM7SF2 &GAMMA;-LINOLENATE BIOSYNTHESIS%BIOCYC%PWY-6000 γ-linolenate biosynthesis SLC27A2 ACSBG2 FADS2 ACSM3 ACSL1 ACSM5 ACSBG1 ACSM4 MRNA CAPPING II%BIOCYC%PWY-7379 mRNA capping II RNGTT RNMT CMTR1 CMTR2 PEPTIDO-CONJUGATES IN TISSUE REGENERATION BIOSYNTHESIS%BIOCYC%PWY-8355 peptido-conjugates in tissue regeneration biosynthesis GGT5 GSTM4 GPX4 ALOX5 ALOX15 DPEP1 ALOX12 LTC4S SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%BIOCYC%PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) IDI1 ACAT2 MVK ACAT1 GGPS1 IDI2 PMVK MVD HMGCR HMGCS2 HMGCS1-1 FDPS L-GLUTAMINE DEGRADATION%BIOCYC%GLUTAMINDEG-PWY L-glutamine degradation GLS2 GLS L-TYROSINE DEGRADATION%BIOCYC%TYRFUMCAT-PWY L-tyrosine degradation GSTZ1 HGD TAT FAH HPD NORADRENALINE AND ADRENALINE DEGRADATION%BIOCYC%PWY-6342 noradrenaline and adrenaline degradation ADH4 ADH1C;ADH1B;ADH1A LRTOMT ALDH3A2 ALDH2 MAOB MAOA COMT PNMT N< I>-ACETYLGLUCOSAMINE DEGRADATION II%BIOCYC%PWY-6517 N< i>-acetylglucosamine degradation II NAGK GNPDA1 GNPDA2 AMDHD2 L-HISTIDINE DEGRADATION%BIOCYC%PWY-5030 L-histidine degradation HAL MTHFD1 UROC1 AMDHD1 FTCD NADH REPAIR%BIOCYC%PWY-6938 NADH repair GAPDH-1 NAXE NAXD URACIL DEGRADATION I (REDUCTIVE)%ARACYC%PWY-3982 uracil degradation I (reductive) DPYS DPYD UPB1 SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%BIOCYC%PWY-6371 superpathway of inositol phosphate compounds PI4K2B MTMR14 PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B PIP4P2 PIP4P1 PLCZ1 PPIP5K1 PPIP5K2 PIP5KL1 PLCE1 PIP4K2A PIP4K2B PIP4K2C IPMK INPPL1 SACM1L PTEN ITPK1 OCRL PLCB3 PLCB4 SYNJ2 PIK3CA INPP5B ITPKB PIK3C3 ITPKC PLCB1 MINPP1 PLCB2 PI4K2A INPP5A IPPK MTMR3 SYNJ1 PIK3R4 PIK3R3 PIK3R2 PIK3R1 INPP5D ITPKA PIK3R6 PIK3R5 INPP5J PLCG2 INPP5K PIP5K1A PIP5K1B PIP5K1C PLCG1 IP6K1 CDIPT IP6K3 IP6K2 FIG4 PIKFYVE PI4KA PLCH1 PLCH2 PI4KB PLCD3 PLCD4 PLCD1 L-PROLINE DEGRADATION%BIOCYC%PROUT-PWY L-proline degradation ALDH4A1 PRODH;LOC102724788 METHYLGLYOXAL DEGRADATION I%BIOCYC%PWY-5386 methylglyoxal degradation I GLO1 HAGH L-ALANINE DEGRADATION%BIOCYC%ALANINE-DEG3-PWY L-alanine degradation GPT GPT2 ACETATE CONVERSION TO ACETYL-COA%BIOCYC%PWY0-1313 acetate conversion to acetyl-CoA ACSS3 ACSS2 ACSS1 SPERMINE AND SPERMIDINE DEGRADATION I%BIOCYC%PWY-6117 spermine and spermidine degradation I AOC3 SMOX SAT2 SAT1 PAOX L-TYROSINE BIOSYNTHESIS%BIOCYC%PWY-6134 L-tyrosine biosynthesis PAH ACYLCERAMIDE BIOSYNTHESIS AND PROCESSING%BIOCYC%PWY-8042 acylceramide biosynthesis and processing SLC27A4 CERS3 TGM1 ALOX12B CYP4F22 ALOXE3 PNPLA1 HOMOCARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-421 homocarnosine biosynthesis CARNS1 UMP BIOSYNTHESIS%BIOCYC%PWY-5686 UMP biosynthesis CAD DHODH UMPS GUANOSINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6608 guanosine nucleotides degradation GDA NT5C2 PNP-1 XDH SUPEROXIDE RADICALS DEGRADATION%BIOCYC%DETOX1-PWY superoxide radicals degradation CAT SOD2 SOD3 SOD1 MYO< I>-INOSITOL BIOSYNTHESIS%BIOCYC%PWY-2301 myo< i>-inositol biosynthesis IMPA1 IMPA2 ISYNA1 AEROBIC RESPIRATION I (CYTOCHROME C)%BIOCYC%PWY-3781 aerobic respiration I (cytochrome c) UQCRC1 NDUFS2 NDUFS1 UQCRC2 NDUFB9 NDUFB8 NDUFB7 UQCRB NDUFB10 NDUFB6 NDUFB11 NDUFB5 NDUFB4 NDUFB3 NDUFA4L2 NDUFB2 NDUFB1 UQCR11 COX7A2 UQCR10 COX5B COX5A NDUFC2;NDUFC2-KCTD14 CYC1 NDUFV3 NDUFV2 NDUFV1 NDUFA9 NDUFA8 NDUFA7 NDUFA6 NDUFA5 NDUFA4 NDUFA3 COX6C UQCRQ NDUFAB1 NDUFS5-1 COX7B NDUFA13 NDUFA11 NDUFA12 COX4I1 NDUFA10 COX6A1 COX7C UQCRFS1 COX8A SDHC NDUFC1 SDHD SDHA SDHB COX6B1 NDUFS8 NDUFS7 NDUFS6 NDUFS4 NDUFS3 DOLICHOL AND DOLICHYL PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6129 dolichol and dolichyl phosphate biosynthesis NUS1 DHRSX SRD5A3 DOLK DHDDS PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-841 purine nucleotides de novo< i> biosynthesis NME2 NME3 NME5 NME1 NME6 RRM2B NME7 RRM2-1 AK1 AK2 GMPS AK3 AK5 PFAS AK7 AK8 ATIC GUK1 PPAT AK4-1 ADSL PAICS IMPDH1 IMPDH2 ADSS1 RRM1 ADSS2 GART NME4-1 NAD SALVAGE PATHWAY IV (FROM NICOTINAMIDE RIBOSIDE)%BIOCYC%PWY3O-4106 NAD salvage pathway IV (from nicotinamide riboside) NMRK1 NMNAT3 NMNAT2 NMNAT1 NMRK2 GABA SHUNT%BIOCYC%GLUDEG-I-PWY GABA shunt ALDH5A1 GAD1 GAD2 ABAT GLUL GLUD1;GLUD2 PENTOSE PHOSPHATE PATHWAY (OXIDATIVE BRANCH)%BIOCYC%OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) G6PD PGLS PGD UBIQUINOL-10 BIOSYNTHESIS (LATE DECARBOXYLATION)%BIOCYC%PWY-5872 ubiquinol-10 biosynthesis (late decarboxylation) UBIAD1 COQ3 COQ2 PDSS2 PDSS1 COQ7 COQ6 COQ5 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7228 guanosine nucleotides de novo< i> biosynthesis NME2 NME3 NME5 NME1 NME6 RRM2B NME7 GMPS RRM2-1 GUK1 IMPDH1 IMPDH2 RRM1 NME4-1 SERINE AND GLYCINE BIOSYNTHESIS%BIOCYC%SER-GLYSYN-PWY serine and glycine biosynthesis VPS29 PSAT1 SHMT2 SHMT1 PHGDH PSPH PURINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7224 purine deoxyribonucleosides salvage NME2 NME3 GUK1 DGUOK NME5 DCK NME1 NME6 NME7 NME4-1 AK5 THYROID HORMONE METABOLISM II (VIA CONJUGATION AND OR DEGRADATION)%BIOCYC%PWY-6261 thyroid hormone metabolism II (via conjugation and or degradation) SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 DIO1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GLUTAMINYL-TRNA^{GLN< SUP> BIOSYNTHESIS VIA TRANSAMIDATION%BIOCYC%PWY-5921 glutaminyl-tRNAgln< sup> biosynthesis via transamidation ASNS GLS2 GLS VITAMIN K-EPOXIDE CYCLE%BIOCYC%PWY-7999 vitamin K-epoxide cycle VKORC1 NQO1 VKORC1L1 GGCX MELATONIN DEGRADATION I%BIOCYC%PWY-6398 melatonin degradation I CYP4X1 CYP2C9;CYP2C19 CYP2U1 CYP2S1 CYP1A2 CYP1B1 CYP2A13;CYP2A6;CYP2A7-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 POR PURINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7179-1 purine deoxyribonucleosides degradation PNP-1 ADA GLUTATHIONE-MEDIATED DETOXIFICATION I%BIOCYC%PWY-4061 glutathione-mediated detoxification I GGT5 GSTM3 GSTK1 GSTO2 GSTP1 MGST3 NAT8-2 MGST1 MGST2 GSTT1 GSTT2B;GSTT2 GSTM1;GSTM2-1 GSTA3;GSTA1 GSTA4 ANPEP GSTA3;GSTA5;GSTA1;GSTA2 GSTZ1 TETRAHYDROFOLATE SALVAGE FROM 5,10-METHENYLTETRAHYDROFOLATE%BIOCYC%PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate MTHFD1 GART ICOSAPENTAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8399 icosapentaenoate metabolites biosynthesis LTA4H PTGS2-2 ALOX5 PUTRESCINE BIOSYNTHESIS I%BIOCYC%PWY-40 putrescine biosynthesis I AZIN2 AGMAT PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS II%BIOCYC%PWY4FS-6 phosphatidylethanolamine biosynthesis II CHKB PCYT2 ETNK2 ETNK1 CEPT1 SELENOI CARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-420 carnosine biosynthesis CARNS1 CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%BIOCYC%PWY66-4 cholesterol biosynthesis III (via desmosterol) SQLE EBP KCNH7 SC5D DHCR24 DHCR7 LSS NSDHL FDFT1 HSD17B7 LBR TM7SF2 PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION%BIOCYC%PWY-7197 pyrimidine deoxyribonucleotide phosphorylation NME2 NME3 NME5 NME1 NME6 NME7 CMPK1 DTYMK CMPK2 NME4-1 PROTECTIN BIOSYNTHESIS%BIOCYC%PWY-8357 protectin biosynthesis GPX4 ALOX15 ALOX12 L-LYSINE DEGRADATION (PIPECOLATE PATHWAY)%BIOCYC%PWY66-425 L-lysine degradation (pipecolate pathway) AADAT PYCR1 PIPOX CRYM DHTKD1 CHONDROITIN SULFATE DEGRADATION (METAZOA)%BIOCYC%PWY-6573 chondroitin sulfate degradation (metazoa) HYAL1 HYAL4 SPAM1 (S)-RETICULINE BIOSYNTHESIS%BIOCYC%PWY-6133 (S)-reticuline biosynthesis TYR ATP BIOSYNTHESIS%BIOCYC%PWY-7980 ATP biosynthesis ATP6V1A ATPAF2-2 ATP5MC2 ATP5MC3 ATP5MC1 ATP5F1A ATP5F1B ATP6V1H ATP6V1E1 ATP6V1D ATP5MG ATP6V1C1 ATP6V1F ATP5ME ATP6V0A1 ATP5PF ATP6V1G1 ATP6V0B VPS9D1 ATP5PD ATP5PB ATP5F1C ATP5F1D ATP6V0E2;ATP6V0E1 ATP6V1B2 ATP5PO ATP6V0D1 ATP6V0C ATPAF1 FOLATE POLYGLUTAMYLATION%BIOCYC%PWY-2161 folate polyglutamylation SHMT2 SHMT1 MTHFD1 MTHFD1L FPGS L-SERINE BIOSYNTHESIS%BIOCYC%SERSYN-PWY L-serine biosynthesis VPS29 PSAT1 PHGDH PSPH L-ASPARAGINE DEGRADATION I%BIOCYC%ASPARAGINE-DEG1-PWY L-asparagine degradation I ASRGL1 ITACONATE BIOSYNTHESIS I%BIOCYC%PWY-5750 itaconate biosynthesis I ACOD1 5-AMINOIMIDAZOLE RIBONUCLEOTIDE BIOSYNTHESIS%BIOCYC%PWY-6121 5-aminoimidazole ribonucleotide biosynthesis PFAS PPAT GART PYRIMIDINE RIBONUCLEOSIDES SALVAGE I%BIOCYC%PWY-7193 pyrimidine ribonucleosides salvage I CDA UCK1 UCKL1 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%BIOCYC%PWY66-5 superpathway of cholesterol biosynthesis ACAT2 SQLE ACAT1 EBP KCNH7 SC5D DHCR24 DHCR7 LSS FDFT1 HMGCS1-1 FDPS IDI1 MVK GGPS1 IDI2 PMVK MVD HMGCR NSDHL HMGCS2 HSD17B7 LBR TM7SF2 PUTRESCINE BIOSYNTHESIS III%BIOCYC%PWY-46 putrescine biosynthesis III ARG2 ODC1 PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY0-1295 pyrimidine ribonucleosides degradation CDA UPP1 KETOGENESIS%HUMANCYC%REACT_1464.NULL ketogenesis ACAT1 HMGCS2 HMGCL BDH2 BDH1 D-GLUCURONATE DEGRADATION%BIOCYC%PWY-5525 D-glucuronate degradation DCXR AKR1A1 CRYL1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6351 D-myo< i>-inositol (1,4,5)-trisphosphate biosynthesis PI4KA PLCH1 PLCH2 PI4KB PLCD3 PLCD4 PLCD1 PI4K2B PLCZ1 PIP5KL1 PLCE1 PIP4K2A PIP4K2B PIP4K2C PLCB3 PLCB4 PLCB1 PLCB2 PI4K2A PLCG2 PIP5K1A PIP5K1B PIP5K1C PLCG1 CDIPT ETHANOL DEGRADATION IV%BIOCYC%PWY66-162 ethanol degradation IV ACSS3 ACSS2 ALDH3A2 ALDH2 ACSS1 CAT CARBON DISULFIDE OXIDATION III (METAZOA)%BIOCYC%PWY-7926 carbon disulfide oxidation III (metazoa) CYP2E1 L-ISOLEUCINE DEGRADATION%BIOCYC%ILEUDEG-PWY L-isoleucine degradation DBT ACAT2 BCKDHB ACAT1 BCAT1 DLD ACADSB HSD17B10 BCAT2 BCKDHA ECHS1 GLYCINE BIOSYNTHESIS%BIOCYC%GLYSYN-ALA-PWY glycine biosynthesis AGXT2 AGXT ARACHIDONATE BIOSYNTHESIS V (8-DETATURASE, MAMMALS)%BIOCYC%PWY-7725 arachidonate biosynthesis V (8-detaturase, mammals) FADS2 ELOVL7 FADS1 SUPERPATHWAY OF GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7835 superpathway of glycosphingolipids biosynthesis B4GALT2 B4GALT3 B4GALT1 FUT2 FUT1 UGCG B3GALT1 ST3GAL4 ST3GAL5 B4GALNT1 ST3GAL6 A4GALT ST3GAL2 ST3GAL3 B3GALNT1 ST6GAL1 ST8SIA1 ST8SIA2 ST8SIA3 B3GALT4 B3GALT5 GBGT1 B3GNT5 B3GNT2 B4GALT6 B4GALT4 HEME DEGRADATION I%BIOCYC%PWY-5874 heme degradation I HMOX1 BLVRA HMOX2 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS III%BIOCYC%PWY-6273 phosphatidylethanolamine biosynthesis III PTDSS2 NEOLACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7841 neolacto-series glycosphingolipids biosynthesis B3GNT5 B3GNT2 B4GALT6 B4GALT4 B4GALT2 B4GALT3 B4GALT1 UGCG ST3GAL4 ST3GAL6 ST6GAL1 ST8SIA2 ST8SIA3 GDP-L-FUCOSE BIOSYNTHESIS II (FROM L-FUCOSE)%BIOCYC%PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) FCSK FPGT GDP-L-FUCOSE BIOSYNTHESIS I (FROM GDP-D-MANNOSE)%BIOCYC%PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) GMDS THIAMINE SALVAGE III%BIOCYC%PWY-6898 thiamine salvage III TPK1 THYMINE DEGRADATION%BIOCYC%PWY-6430 thymine degradation DPYS DPYD UPB1 S< I>-METHYL-5'-THIOADENOSINE DEGRADATION%BIOCYC%PWY-6756 S< i>-methyl-5'-thioadenosine degradation MTAP NAD PHOSPHORYLATION AND TRANSHYDROGENATION%BIOCYC%NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and transhydrogenation NNT NADK CHOLINE DEGRADATION%BIOCYC%CHOLINE-BETAINE-ANA-PWY choline degradation CHDH ALDH7A1 ADENINE AND ADENOSINE SALVAGE VI%BIOCYC%PWY-6619 adenine and adenosine salvage VI ADK PLASMALOGEN BIOSYNTHESIS%BIOCYC%PWY-7782 plasmalogen biosynthesis PCYT1B PCYT1A PEDS1-UBE2V1;PEDS1 CHKA AGPAT1 GNPAT AGPS CHKB FAR1 PCYT2 FAR2 ETNK2 ETNK1 CEPT1 SELENOI L-DOPA AND L-DOPACHROME BIOSYNTHESIS%BIOCYC%PWY-6481 L-dopa and L-dopachrome biosynthesis TYR L-TRYPTOPHAN DEGRADATION XI (MAMMALIAN, VIA KYNURENINE)%BIOCYC%PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) TDO2 KYNU AFMID KYAT3 ALDH8A1 IDO2 IDO1 AADAT DHTKD1 KYAT1 GOT2-1 HAAO KMO ACMSD ESTRADIOL BIOSYNTHESIS I (VIA ESTRONE)%BIOCYC%PWY66-380 estradiol biosynthesis I (via estrone) CYP2A13;CYP2A6;CYP2A7-1 HSD17B1 CYP19A1 HSD17B3 HSD17B7 HSD17B11 ICOSAPENTAENOATE BIOSYNTHESIS III (8-DESATURASE, MAMMALS)%BIOCYC%PWY-7724 icosapentaenoate biosynthesis III (8-desaturase, mammals) FADS2 ELOVL5 ELOVL7 FADS1 ACSM3 ACSL1 ACSM5 ACSM4 SULFITE OXIDATION%BIOCYC%PWY-5326 sulfite oxidation SUOX HISTAMINE BIOSYNTHESIS%BIOCYC%PWY-6173 histamine biosynthesis HDC GANGLIO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7836 ganglio-series glycosphingolipids biosynthesis UGCG ST3GAL5 B4GALT6 B4GALNT1 ST3GAL2 ST3GAL3 ST6GAL1 ST8SIA1 B3GALT4 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 1 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7832 ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide B3GALT1 ST3GAL3 FUT6;FUT5;FUT3 FUT2 B3GALT5 METHYLGLYOXAL DEGRADATION III%BIOCYC%PWY-5453 methylglyoxal degradation III AKR1B15;AKR1B10 AKR1B1 CYP2E1 S-ADENOSYL-L-METHIONINE BIOSYNTHESIS%BIOCYC%SAM-PWY S-adenosyl-L-methionine biosynthesis MAT1A MAT2B MAT2A PLASMALOGEN DEGRADATION%BIOCYC%PWY-7783 plasmalogen degradation TMEM86B ENPP2 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY0-162 superpathway of pyrimidine ribonucleotides de novo< i> biosynthesis CAD NME2 CTPS2 NME3 CTPS1 NME5 DHODH NME1 NME6 NME7 CMPK1 CMPK2 UMPS NME4-1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS V (FROM INS(1,3,4)P3)%BIOCYC%PWY-6554 1D-myo< i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) IPPK IPMK ITPK1 GLYCINE SERINE BIOSYNTHESIS%BIOCYC%GLYSYN-PWY glycine serine biosynthesis SHMT2 SHMT1 OLEATE BIOSYNTHESIS%BIOCYC%PWY-5996 oleate biosynthesis SCD FADS6 SCD5 ACOT2;ACOT1 ACOT4 C20 PROSTANOID BIOSYNTHESIS%HUMANCYC%15369 C20 prostanoid biosynthesis TBXAS1 PTGDS PTGR1-1 CBR1-1 PTGES PTGS2-2 PTGES3-1 PTGIS HPGD PTGES2 PTGR2 PTGS1 HPGDS 3-PHOSPHOINOSITIDE DEGRADATION%BIOCYC%PWY-6368 3-phosphoinositide degradation TPTE;TPTE2 INPP4A INPP4B SACM1L INPPL1 INPP5E PTEN OCRL SYNJ2 INPP5B MTMR3 SYNJ1 INPP5F INPP5D MTMR14 INPP5J INPP5K PIP4P2 PIP4P1 ULTRA-LONG-CHAIN FATTY ACID BIOSYNTHESIS%BIOCYC%PWY-8041 ultra-long-chain fatty acid biosynthesis ELOVL4 TECR HSD17B12 COENZYME A BIOSYNTHESIS II (EUKARYOTIC)%BIOCYC%PWY-7851 coenzyme A biosynthesis II (eukaryotic) PPCS COASY PPCDC RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-397 resolvin D biosynthesis GPX4 ALOX5 ALOX15 ALOX12 EPHX3 ACETONE DEGRADATION I (TO METHYLGLYOXAL)%BIOCYC%PWY-5451 acetone degradation I (to methylglyoxal) CYP4X1 CYP2U1 CYP2S1 CYP2A13;CYP2A6;CYP2A7-1 CYP2E1 ARACHIDONATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8397 arachidonate metabolites biosynthesis PTGES3-1 PTGIS HPGD PTGES2 PTGR2 PTGS1 HPGDS TBXAS1 PTGDS PTGR1-1 PTGES GGT5 GSTM4 GPX4 ALOX5 ALOX15 DPEP1 ALOX12 LTC4S EPHX3 CYP2J2-1 CYP2D6;LOC107987479;LOC107987478-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX15B DPEP2 LTA4H PTGS2-2 PROTEIN CITRULLINATION%BIOCYC%PWY-4921 protein citrullination PADI6 PADI3 PADI2 PADI4 PADI1 L-PHENYLALANINE DEGRADATION I (AEROBIC)%BIOCYC%PHENYLALANINE-DEG1-PWY L-phenylalanine degradation I (aerobic) PAH PHOSPHATIDYLSERINE BIOSYNTHESIS II%BIOCYC%PWY-7506 phosphatidylserine biosynthesis II PTDSS2 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6364 D-myo< i>-inositol (1,3,4)-trisphosphate biosynthesis IPMK INPPL1 PTEN OCRL SYNJ2 INPP5B ITPKB ITPKC MINPP1 INPP5A SYNJ1 INPP5D ITPKA INPP5J INPP5K INOSITOL DIPHOSPHATES BIOSYNTHESIS%BIOCYC%PWY-6369 inositol diphosphates biosynthesis IP6K3 IPPK PPIP5K1 IP6K2 PPIP5K2 IPMK IP6K1 THYRONAMINE AND IODOTHYRONAMINE METABOLISM%BIOCYC%PWY-6688 thyronamine and iodothyronamine metabolism DIO1 DIO3 THIOREDOXIN PATHWAY%BIOCYC%THIOREDOX-PWY thioredoxin pathway TXNRD3 TXNRD2 TXNRD1 15-EPI< I>-LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-393 15-epi< i>-lipoxin biosynthesis PTGS2-2 ALOX5 ACETYL-COA BIOSYNTHESIS FROM CITRATE%BIOCYC%PWY-5172 acetyl-CoA biosynthesis from citrate ACLY KETOLYSIS%HUMANCYC%REACT_59.NULL ketolysis ACAT1 BDH2 BDH1 OXCT1-1 2'-DEOXY-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-7180 2'-deoxy-α-D-ribose 1-phosphate degradation ALDH3B2;ALDH3B1 ALDH1B1 PGM2 DERA ALDH3A1 ANANDAMIDE LIPOXYGENATION%BIOCYC%PWY-8056 anandamide lipoxygenation ALOX5 ALOX15 ALOX12 L-METHIONINE SALVAGE FROM L-HOMOCYSTEINE%BIOCYC%ADENOSYLHOMOCYSCAT-PWY L-methionine salvage from L-homocysteine BHMT BHMT2 MTR-1 SUPERPATHWAY OF MELATONIN DEGRADATION%BIOCYC%PWY-6402 superpathway of melatonin degradation CYP4X1 CYP2C9;CYP2C19 CYP2U1 CYP2S1 CYP1A2 MAOA CYP1B1 CYP2A13;CYP2A6;CYP2A7-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 POR 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION TO GLUTARYL-COA%BIOCYC%PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA ALDH8A1 DHTKD1 ACMSD GLUTATHIONE-PEROXIDE REDOX REACTIONS%BIOCYC%PWY-4081 glutathione-peroxide redox reactions GPX1 GPX4 GSR GPX7 NAD SALVAGE%BIOCYC%NAD-BIOSYNTHESIS-III NAD salvage NMNAT3 NMNAT2 NAMPT NMNAT1 HISTAMINE DEGRADATION%BIOCYC%PWY-6181 histamine degradation AOC1 HNMT CDP-DIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-5667 CDP-diacylglycerol biosynthesis CDS1 MBOAT7 MBOAT1 MBOAT2 ABHD5 LCLAT1 AGPAT2 AGPAT3 AGPAT4 GPAM AGPAT1 LPCAT4 GPAT4 LPCAT3 AGPAT5-1 GPAT3 GPAT2 CDS2 RAPOPORT-LUEBERING GLYCOLYTIC SHUNT%BIOCYC%PWY-6405 Rapoport-Luebering glycolytic shunt BPGM MINPP1 FATTY ACID &ALPHA;-OXIDATION III%BIOCYC%PWY66-388 fatty acid α-oxidation III HACL1 ALDH3A2 FA2H GLUCONEOGENESIS%BIOCYC%PWY66-399 gluconeogenesis GPI TPI1 MDH1 MDH2 PGAM1 PGAM2 ENO1 ENO2 ENO3 G6PC1 G6PC2 G6PC3 PC GAPDHS PGK1 GAPDH-1 ALDOC ALDOB ALDOA PCK1 FBP1 FBP2 BPGM PHENYLETHYLAMINE DEGRADATION I%BIOCYC%2PHENDEG-PWY phenylethylamine degradation I ALDH3A2 ALDH2 AOC3 MAOB MAOA AOC2 PENTOSE PHOSPHATE PATHWAY (NON-OXIDATIVE BRANCH)%BIOCYC%NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) RPIA RPE;RPEL1 TALDO1 TKT VERY LONG CHAIN FATTY ACID BIOSYNTHESIS II%BIOCYC%PWY-7036 very long chain fatty acid biosynthesis II ELOVL7 TECR ELOVL1 HSD17B12 ARACHIDONATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7592 arachidonate biosynthesis III (6-desaturase, mammals) SLC27A2 ACSBG2 FADS2 ELOVL5 ELOVL7 FADS1 ACSM3 ACSL1 HSD17B12 ACSM5 ACSBG1 ACSM4 D-MYO< I>-INOSITOL (3,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6365 D-myo< i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis IPMK ITPK1 &GAMMA;-GLUTAMYL CYCLE%BIOCYC%PWY-4041 γ-glutamyl cycle OPLAH CNDP2 GGT5 GGCT GCLC GSS GCLM UTP AND CTP DEPHOSPHORYLATION I%BIOCYC%PWY-7185 UTP and CTP dephosphorylation I CTPS2 CTPS1 NTPCR GLYCOGENOLYSIS%BIOCYC%PWY-5941 glycogenolysis HK3 PGM2 PYGB MGAM HKDC1 PYGM PYGL PGM1 HK2 GCK HK1 L-VALINE DEGRADATION%BIOCYC%VALDEG-PWY L-valine degradation DBT BCKDHB BCAT1 DLD ABAT BCAT2 ACAD8 ALDH6A1 HIBADH BCKDHA ECHS1 HIBCH ARG N-END RULE PATHWAY (EUKARYOTIC)%BIOCYC%PWY-7799 Arg N-end rule pathway (eukaryotic) ATE1 NAA20 NAA25 NTAQ1 APEH NTAN1 METAP1 METAP2 ASPIRIN TRIGGERED RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-395 aspirin triggered resolvin D biosynthesis PTGS2-2 ALOX5 L-ASPARTATE BIOSYNTHESIS%BIOCYC%ASPARTATESYN-PWY L-aspartate biosynthesis GOT1-1 GOT1L1 OXIDIZED GTP AND DGTP DETOXIFICATION%BIOCYC%PWY-6502 oxidized GTP and dGTP detoxification NUDT1 GDP-GLUCOSE BIOSYNTHESIS II%BIOCYC%PWY-5661-1 GDP-glucose biosynthesis II HK3 PGM2 HKDC1 PGM1 HK2 GCK HK1 MELATONIN DEGRADATION II%BIOCYC%PWY-6399 melatonin degradation II MAOA TRNA SPLICING II%BIOCYC%PWY-7803 tRNA splicing II TSEN2 C2orf49 TSEN54 RTRAF TSEN34 TSEN15 DDX1 RTCB ZBTB8OS FAM98B PYRIMIDINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7199 pyrimidine deoxyribonucleosides salvage CDA TK2 TK1 TYMS DCK PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7184 pyrimidine deoxyribonucleotides de novo< i> biosynthesis NME2 NME3 NTPCR NME5 TYMS NME1 NME6 RRM2B NME7 RRM2-1 RRM1 DUT DTYMK NME4-1 L-PROLINE BIOSYNTHESIS%BIOCYC%PROSYN-PWY L-proline biosynthesis PYCR2 ALDH18A1 PYCR1 4-HYDROXY-2-NONENAL DETOXIFICATION%BIOCYC%PWY-7112 4-hydroxy-2-nonenal detoxification GSTA3;GSTA1 GSTA4 GSTA3;GSTA5;GSTA1;GSTA2 GSTP1 PURINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6353 purine nucleotides degradation GDA NT5C2 PNP-1 XDH ADA NT5C3A NT5E IMPDH1 NT5C1A IMPDH2 NT5C1B;NT5C1B-RDH14 L-CYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6292 L-cysteine biosynthesis MAT1A MAT2B CBS;CBSL CTH AHCY MAT2A L-METHIONINE SALVAGE CYCLE%BIOCYC%PWY-7527 L-methionine salvage cycle MAT1A MAT2B ADI1 APIP MTAP MRI1 SRM KYAT1 MAT2A ENOPH1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%BIOCYC%PWY-6363 D-myo< i>-inositol (1,4,5)-trisphosphate degradation INPP1 INPPL1 OCRL SYNJ2 INPP5B INPP5A BPNT2-1 SYNJ1 INPP5F IMPA1 IMPA2 INPP5J INPP5K 2-METHYL-BRANCHED FATTY ACID &BETA;-OXIDATION%BIOCYC%PWY-8181 2-methyl-branched fatty acid β-oxidation ACADSB BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL BMP Signalling Pathway BMP2 ZFYVE16 BMPR2 BMPR1B ACVR2A SKI SMAD4 LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 leukotriene biosynthesis DPEP2 GGT5 LTA4H GSTM4 ALOX5 DPEP1 LTC4S PROGESTERONE BIOSYNTHESIS%BIOCYC%PWY-7299 progesterone biosynthesis HSD3B1;HSD3B2 L-GLUTAMATE BIOSYNTHESIS%BIOCYC%GLUTAMATE-SYN2-PWY L-glutamate biosynthesis GLUD1;GLUD2 RETINOATE BIOSYNTHESIS II%BIOCYC%PWY-6875 retinoate biosynthesis II XDH RBP4 RBP5 RBP1 GLUTATHIONE BIOSYNTHESIS%BIOCYC%GLUTATHIONESYN-PWY glutathione biosynthesis GCLC GSS GCLM DOPAMINE DEGRADATION%BIOCYC%PWY6666-2 dopamine degradation ALDH3A2 MAOB MAOA COMT SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 MARESIN BIOSYNTHESIS%BIOCYC%PWY-8356 maresin biosynthesis ALOX15 ALOX12 EPHX3 L-ASPARTATE DEGRADATION I%BIOCYC%ASPARTATE-DEG1-PWY L-aspartate degradation I GOT1-1 GOT1L1 GALA-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7840 gala-series glycosphingolipids biosynthesis ST3GAL5 UGT8 GAL3ST1 SORBITOL DEGRADATION I%BIOCYC%PWY-4101 sorbitol degradation I SORD PYRUVATE FERMENTATION TO (S< I>)-LACTATE%BIOCYC%PWY-5481 pyruvate fermentation to (S< i>)-lactate LDHB LDHA;LDHC LDHA PUTRESCINE DEGRADATION III%BIOCYC%PWY-0 putrescine degradation III ALDH3B2;ALDH3B1 ALDH1B1 ALDH3A2 ALDH2 MAOB MAOA SAT2 SAT1 ALDH3A1 CREATINE-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6158 creatine-phosphate biosynthesis CKMT1A;CKMT1B CKM CKB CKMT2 QUEUOSINE BIOSYNTHESIS II (QUEUINE SALVAGE)%BIOCYC%PWY-8105 queuosine biosynthesis II (queuine salvage) QTRT1 QTRT2 L-LEUCINE DEGRADATION%BIOCYC%LEU-DEG2-PWY L-leucine degradation DBT BCKDHB BCAT1 DLD MCCC2 AUH BCAT2 IVD HMGCL MCCC1 HMGCLL1 BCKDHA GLYCEROL-3-PHOSPHATE SHUTTLE%BIOCYC%PWY-6118 glycerol-3-phosphate shuttle GPD1 L-ASPARAGINE DEGRADATION%BIOCYC%ASPARAGINE-DEG1-PWY-1 L-asparagine degradation ASRGL1 GOT1-1 AGA SEROTONIN DEGRADATION%BIOCYC%PWY-6313 serotonin degradation ADH1C;ADH1B;ADH1A ALDH3A2 ALDH2 MAOA SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ADENOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7219 adenosine ribonucleotides de novo< i> biosynthesis AK7 AK8 AK4-1 ADSL AK1 ADSS1 AK2 ADSS2 AK3 AK5 ACYL-COA HYDROLYSIS%BIOCYC%PWY-5148 acyl-CoA hydrolysis ACOT9 ACOT8 ACOT7 ANANDAMIDE BIOSYNTHESIS II%BIOCYC%PWY-8053 anandamide biosynthesis II PLAAT3 PLAAT2 PLAAT5 PLAAT4 PLAAT1 L-TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde TDO2 KYNU AFMID IDO2 IDO1 HAAO KMO UDP-&ALPHA;-D-XYLOSE BIOSYNTHESIS%BIOCYC%PWY-4821 UDP-α-D-xylose biosynthesis UGDH UXS1 PHOSPHOLIPASES%BIOCYC%LIPASYN-PWY phospholipases PLCH1 PLCH2 PLCD3 PLCD4 PLCD1 PLAAT1 PLAAT3 PLAAT2 PLAAT5 PLAAT4 PLA2G1B PLD4 PLA2G3 PLA2G5 PLD6 PLD1 PLA2G6 PLB1 PLA2G2A-1 PLD3 PLD2 PLCZ1 OC90 JMJD7-PLA2G4B;PLA2G4B PLA2G10;LOC100652777 PLCE1 PLA2G2F PLA2G4F PLA2G2D PLA2G12A PLA2G2E PLA2G4D PLA2G4E PLCB3 PNPLA8 PLCB4 PLA2G4A PLCB1 PLCB2 PLCG2 PLCG1 EPOXYSQUALENE BIOSYNTHESIS%BIOCYC%PWY-5670 epoxysqualene biosynthesis SQLE FDFT1 CARDENOLIDE BIOSYNTHESIS%BIOCYC%PWY-6032 cardenolide biosynthesis SRD5A2 SRD5A1 CHOLESTEROL BIOSYNTHESIS I%BIOCYC%PWY66-341 cholesterol biosynthesis I SQLE EBP KCNH7 SC5D DHCR24 DHCR7 LSS NSDHL FDFT1 HSD17B7 LBR TM7SF2 OPHTHALMATE BIOSYNTHESIS%BIOCYC%PWY-8043 ophthalmate biosynthesis GOT1-1 GCLC GSS GCLM COENZYME A BIOSYNTHESIS%BIOCYC%COA-PWY-1 coenzyme A biosynthesis PANK1 PPCS COASY PPCDC PANK3 SUCROSE DEGRADATION%BIOCYC%PWY66-373 sucrose degradation ALDOC TKFC ALDOB TPI1 SI ALDOA KHK PRPP BIOSYNTHESIS%BIOCYC%PWY0-662 PRPP biosynthesis PRPS2 PRPS1 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE%BIOCYC%PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage NME2 NME3 TK2 TK1 NME5 TYMS NME1 NME6 NME7 CMPK1 CMPK2 CDA DCK DTYMK NME4-1 PHOSPHATIDYLCHOLINE BIOSYNTHESIS%BIOCYC%PWY3O-450 phosphatidylcholine biosynthesis PCYT1B PCYT1A CHKA CHPT1 CHKB CEPT1 SUPERPATHWAY OF L-TRYPTOPHAN UTILIZATION%BIOCYC%PWY66-401 superpathway of L-tryptophan utilization TDO2 ADH1C;ADH1B;ADH1A KYNU NMNAT3 AFMID NMNAT2 ALDH2 MAOB ALDH8A1 MAOA IDO2 IDO1 DHTKD1 TPH2 DDC TPH1 AANAT ASMT CYP2A13;CYP2A6;CYP2A7-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GCDH ECHS1 POR ACAT2 CYP4X1 ACAT1 CYP2C9;CYP2C19 CYP2U1 ALDH3A2 CYP2S1 CYP1A2 CYP1B1 QPRT NADSYN1 AKR1A1 HAAO KMO NMNAT1 ACMSD FATTY ACID &BETA;-OXIDATION (PEROXISOME)%BIOCYC%PWY66-391 fatty acid β-oxidation (peroxisome) SLC27A2 ACSBG2 HSD17B10 ACOX2 SCP2 EHHADH-1 ACOX1 ACAA1-1 HSD17B4 ACSBG1 HADH ECHS1 L-TRYPTOPHAN DEGRADATION VIA TRYPTAMINE%BIOCYC%PWY-6307 L-tryptophan degradation via tryptamine ALDH3A2 DDC MAOB AKR1A1 TRNA CHARGING%BIOCYC%TRNA-CHARGING-PWY tRNA charging AARS2 KARS1 PARS2 YARS1 YARS2 FARS2 NARS1 QARS1 NARS2 IARS2 IARS1 VARS2 EARS2 VARS1 RARS2 HARS1 RARS1 MARS2 MARS1 DARS2 HARS2 DARS1 WARS1 WARS2 LARS2 GARS1 SARS1 SARS2 EPRS1 LARS1 TARS2 TARS3 FARSA CARS1 CARS2 TARS1 FARSB AARS1 PYRIDOXAL 5'-PHOSPHATE SALVAGE%BIOCYC%PLPSAL-PWY-1 pyridoxal 5'-phosphate salvage PDXK PNPO N< I>-ACETYLGLUCOSAMINE DEGRADATION I%BIOCYC%GLUAMCAT-PWY N< i>-acetylglucosamine degradation I GNPDA1 GNPDA2 AMDHD2 4-HYDROXYBENZOATE BIOSYNTHESIS%BIOCYC%PWY-5754 4-hydroxybenzoate biosynthesis TAT SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE%BIOCYC%PWY66-409 superpathway of purine nucleotide salvage NME2 NME3 NME5 NME1 NME6 RRM2B NME7 RRM2-1 PNP-1 ADA APRT HPRT1 AK1 AK2 GMPS AK3 AK5 AK7 ADK AK8 GUK1 AK4-1 ADSL IMPDH1 IMPDH2 ADSS1 RRM1 ADSS2 NME4-1 SPHINGOLIPID BIOSYNTHESIS (MAMMALS)%BIOCYC%PWY-7277 sphingolipid biosynthesis (mammals) SPTLC1 SPTLC3 DEGS1 KDSR CERS1 PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP%BIOCYC%PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP NME2 NME3 NTPCR NME5 TYMS NME1 NME6 RRM2B NME7 DCTD RRM2-1 RRM1 DTYMK NME4-1 UTP AND CTP DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7176 UTP and CTP de novo< i> biosynthesis NME2 CTPS2 NME3 CTPS1 NME5 NME1 NME6 NME7 CMPK1 CMPK2 NME4-1 SUPERPATHWAY OF CHOLINE DEGRADATION TO L-SERINE%BIOCYC%PWY66-414 superpathway of choline degradation to L-serine CHDH ALDH7A1 SHMT2 SHMT1 BHMT DMGDH TCA CYCLE%BIOCYC%PWY66-398 TCA cycle MDH1 DLD MDH2 FH IDH3G DLST CS SUCLA2 SDHC IDH3B OGDH SDHD SUCLG2 SDHA SUCLG1 SDHB ACO2 IDH3A N< I>1< SUP>-METHYL-N< I>3< SUP>-AMINOCARBOXYPROPYL-PSEUDOURIDINE-MODIFIED RRNA BIOSYNTHESIS%BIOCYC%PWY-8341 N< i>1< sup>-methyl-N< i>3< sup>-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis EMG1 TSR3 FATTY ACID &BETA;-OXIDATION%BIOCYC%FAO-PWY fatty acid β-oxidation ECI1 SLC27A2 ACSBG2 HSD17B10 SCP2 HADHA HADHB-1 ACSBG1 HADH ACAA2 ECHS1 CERAMIDE DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY3DJ-12 ceramide de novo< i> biosynthesis SPTLC1 SPTLC3 DEGS1 KDSR CERS1 ARACHIDONATE BIOSYNTHESIS IV (8-DETATURASE)%BIOCYC%PWY-7601 arachidonate biosynthesis IV (8-detaturase) ELOVL7 ERYTHRITOL BIOSYNTHESIS II%BIOCYC%PWY-8373 erythritol biosynthesis II ADH1C;ADH1B;ADH1A SORD LACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7839 lacto-series glycosphingolipids biosynthesis UGCG B3GNT5 B3GALT1 ST3GAL5 B4GALT6 ST6GAL1 FUT2 B3GALT5 L-SERINE DEGRADATION%BIOCYC%SERDEG-PWY L-serine degradation SDSL TETRAHYDROPTERIDINE RECYCLING%BIOCYC%PWY-8099 tetrahydropteridine recycling PCBD1 PCBD2 SPERMIDINE BIOSYNTHESIS%BIOCYC%BSUBPOLYAMSYN-PWY spermidine biosynthesis SRM TETRAHYDROBIOPTERIN DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-5663 tetrahydrobiopterin de novo< i> biosynthesis GCH1 SPR PTS L-TRYPTOPHAN DEGRADATION (KYNURENINE PATHWAY)%BIOCYC%TRYPTOPHAN-DEGRADATION-1 L-tryptophan degradation (kynurenine pathway) ACAT2 TDO2 ACAT1 KYNU AFMID ALDH8A1 IDO2 IDO1 DHTKD1 HAAO GCDH KMO ECHS1 ACMSD PROTEIN O< I>-[N< I>-ACETYL]-GLUCOSYLATION%BIOCYC%PWY-7437 protein O< i>-[N< i>-acetyl]-glucosylation OGA OGT-1 CYTOCHROME C< I> BIOGENESIS%BIOCYC%PWY-8145 cytochrome c< i> biogenesis HCCS RETINOATE BIOSYNTHESIS I%BIOCYC%PWY-6872 retinoate biosynthesis I RBP4 RBP5 RBP1 SDR16C5 ALDH1A3 ALDH1A2 ALDH1A1 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 2 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7831 ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide ST3GAL4 ST3GAL3 B4GALT2 B4GALT3 ST8SIA2 FUT6;FUT5;FUT3 B4GALT1 FUT9 CHST1 FUT1 CMP PHOSPHORYLATION%BIOCYC%PWY-7205 CMP phosphorylation NME2 NME3 NME5 NME1 NME6 NME7 CMPK1 CMPK2 NME4-1 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7209 superpathway of pyrimidine ribonucleosides degradation CDA DPYS DPYD UPB1 UPP1 THYROID HORMONE METABOLISM I (VIA DEIODINATION)%BIOCYC%PWY-6260 thyroid hormone metabolism I (via deiodination) DIO1 DIO3 ICOSAPENTAENOATE BIOSYNTHESIS II (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7049 icosapentaenoate biosynthesis II (6-desaturase, mammals) FADS2 ELOVL5 FADS1 ACSM3 ACSL1 ACSM5 ACSM4 I ANTIGEN AND I ANTIGEN BIOSYNTHESIS%BIOCYC%PWY-7837 i antigen and I antigen biosynthesis GCNT2 GCNT3 B3GNT2 B4GALT2 B4GALT3 B4GALT1 FATTY ACID &BETA;-OXIDATION (UNSATURATED, ODD NUMBER)%BIOCYC%PWY-5137 fatty acid β-oxidation (unsaturated, odd number) ECI1 ECI2 GLYCOLYSIS%BIOCYC%PWY66-400 glycolysis GPI TPI1 HK3 PGAM1 HKDC1 PGAM2 ENO1 ENO2 ENO3 HK2 GCK HK1 GAPDHS PGK1 GAPDH-1 ALDOC ALDOB ALDOA PKLR PFKL PKM PFKM PFKP BPGM HYDROGEN SULFIDE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY66-426 hydrogen sulfide biosynthesis II (mammalian) CBS;CBSL CTH HUMAN MILK OLIGISACCHARIDES BIOSYNTHESIS%BIOCYC%PWY-8459 human milk oligisaccharides biosynthesis GCNT3 B3GNT2 B4GALT4 LALBA ST3GAL3 ST6GALNAC6 ST6GAL1 B4GALT2 FUT6;FUT5;FUT3 B4GALT1 FUT2 B3GALT5 INOSINE 5'-PHOSPHATE DEGRADATION%BIOCYC%PWY-5695 inosine 5'-phosphate degradation NT5C2 PNP-1 XDH NT5E IMPDH1 IMPDH2 HEME BIOSYNTHESIS FROM UROPORPHYRINOGEN-III I%BIOCYC%HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I FECH UROD CPOX PPOX MITOCHONDRIAL L-CARNITINE SHUTTLE%BIOCYC%PWY-6111 mitochondrial L-carnitine shuttle SLC25A20 CPT1C CPT1B CPT1A CPT2 EUMELANIN BIOSYNTHESIS%BIOCYC%PWY-6498 eumelanin biosynthesis TYR DCT TRPC1 TYRP1 FATTY ACID BIOSYNTHESIS INITIATION (MITOCHONDRIA)%BIOCYC%PWY66-429 fatty acid biosynthesis initiation (mitochondria) NDUFAB1 OXSM MCAT ACSF3 ANANDAMIDE DEGRADATION%BIOCYC%PWY6666-1 anandamide degradation FAAH FAAH2 FORMALDEHYDE OXIDATION II (GLUTATHIONE-DEPENDENT)%ECOCYC%PWY-1801 formaldehyde oxidation II (glutathione-dependent) ESD ADH5 GLOBO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7838 globo-series glycosphingolipids biosynthesis UGCG GBGT1 B4GALT6 A4GALT ST3GAL2 B3GALNT1 FUT2 B3GALT5 FUT1 TREHALOSE DEGRADATION%BIOCYC%PWY0-1182 trehalose degradation HK3 HK2 GCK HK1 TREH LINOLEATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8395 linoleate metabolites biosynthesis EPHX4 CYP2C9;CYP2C19 EPHX2 EPHX3 EPHX1 THE VISUAL CYCLE I (VERTEBRATES)%BIOCYC%PWY-6861 the visual cycle I (vertebrates) RDH8 RLBP1 RPE65 DHRS3 DHRS4 RBP4 RBP2 RBP5 RDH12 DHRS9 RBP1 RBP3 RDH11 RDH10 RDH5 LRAT ANDROGEN BIOSYNTHESIS%BIOCYC%PWY66-378 androgen biosynthesis HSD3B1;HSD3B2 HSD17B3 SRD5A2 SRD5A1 CYP17A1 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7221 guanosine ribonucleotides de novo< i> biosynthesis NME2 NME3 GUK1 NME5 IMPDH1 NME1 NME6 IMPDH2 NME7 GMPS NME4-1 RETINOL BIOSYNTHESIS%BIOCYC%PWY-6857 retinol biosynthesis LIPC BCO1 PNLIP CES2 CES1 RDH8 DHRS3 DHRS4 RBP4 RBP2 RBP5 RDH12 DHRS9 RBP1 RDH11 RDH10 LRAT CES5A DOCOSAHEXAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8400 docosahexaenoate metabolites biosynthesis CYP2D6;LOC107987479;LOC107987478-1 PTGS2-2 GPX4 ALOX5 ALOX15 ALOX12 EPHX3 3-PHOSPHOINOSITIDE BIOSYNTHESIS%BIOCYC%PWY-6352 3-phosphoinositide biosynthesis FIG4 PIKFYVE PI4KA PI4KB PI4K2B PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B PIP5KL1 PIP4K2B SACM1L PIK3CA PIK3C3 PI4K2A PIK3R4 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 PIP5K1A PIP5K1B PIP5K1C CDIPT UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%BIOCYC%PWY-5514 UDP-N< i>-acetyl-D-galactosamine biosynthesis II GPI HK3 GALE HKDC1 PGM3 GNPNAT1 GNPDA1 UAP1 GNPDA2 HK2 GCK HK1 4-AMINOBUTANOATE DEGRADATION I%BIOCYC%PWY-6535 4-aminobutanoate degradation I ALDH5A1 ABAT CMP-2-KETO-3-DEOXY-D-GLYCERO< I>-D-GALACTO< I>-NONONATE BIOSYNTHESIS%BIOCYC%PWY-6140 CMP-2-keto-3-deoxy-D-glycero< i>-D-galacto< i>-nononate biosynthesis HKDC1 L-CYSTEINE DEGRADATION I%BIOCYC%CYSTEINE-DEG-PWY L-cysteine degradation I GOT1-1 CDO1 STEARATE BIOSYNTHESIS%BIOCYC%PWY-5972 stearate biosynthesis SLC27A2 ACSBG2 ACOT2;ACOT1 ACOT4 ELOVL7 ELOVL6 ACSL1 HSD17B12 ACOT7 ACSBG1 &BETA;-ALANINE DEGRADATION%BIOCYC%BETA-ALA-DEGRADATION-I-PWY β-alanine degradation ABAT TRANS< I>-4-HYDROXY-L-PROLINE DEGRADATION%BIOCYC%HYDROXYPRODEG-PWY trans< i>-4-hydroxy-L-proline degradation ALDH4A1 HOGA1 GOT2-1 PRODH2 &ALPHA;-TOCOPHEROL DEGRADATION%BIOCYC%PWY-6377 α-tocopherol degradation CYP4F3;CYP4F2;CYP4F12;CYP4F11 DOCOSAHEXAENOATE BIOSYNTHESIS IV (4-DESATURASE, MAMMALS)%BIOCYC%PWY-7727 docosahexaenoate biosynthesis IV (4-desaturase, mammals) FADS2 ELOVL5 ELOVL2 HSD17B12 LANOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6132 lanosterol biosynthesis LSS SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%BIOCYC%PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism SLC27A2 ACSBG2 PTGR1-1 ASAH1 ASAH2 SPHK2 SPHK1 SGPP2 SGPP1 ACER2 ACER1 ACSL1 ACSBG1 PURINE RIBONUCLEOSIDES DEGRADATION TO RIBOSE-1-PHOSPHATE%BIOCYC%PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate PGM2 PNP-1 ADA PYRIMIDINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7181 pyrimidine deoxyribonucleosides degradation CDA TYMP UPP1 D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%BIOCYC%PWY-6367 D-myo< i>-inositol-5-phosphate metabolism PLCZ1 PLCE1 PIP4K2A PLCH1 PLCH2 PIP4K2C PLCD3 PLCD4 PLCB3 PLCD1 PLCB4 PLCB1 PLCB2 MTMR3 MTMR14 PLCG2 PLCG1 PIP4P2 PIP4P1 ALLOPREGNANOLONE BIOSYNTHESIS%BIOCYC%PWY-7455 allopregnanolone biosynthesis SRD5A2 SRD5A1 SPERMINE BIOSYNTHESIS%BIOCYC%ARGSPECAT-PWY spermine biosynthesis SMS FOLATE TRANSFORMATIONS I%BIOCYC%PWY-2201-1 folate transformations I SHMT2 SHMT1 MTR-1 ST20-MTHFS;MTHFS ALDH1L1 MTHFD2 MTHFD2L MTHFR MTHFD1 ALDH1L2 MTHFD1L GLYCEROL DEGRADATION%BIOCYC%PWY-4261 glycerol degradation GK5 GK GK2 D-MANNOSE DEGRADATION%BIOCYC%MANNCAT-PWY-1 D-mannose degradation MPI L-METHIONINE DEGRADATION%BIOCYC%METHIONINE-DEG1-PWY L-methionine degradation MAT1A MAT2B AHCY MAT2A ADENINE AND ADENOSINE SALVAGE III%BIOCYC%PWY-6609 adenine and adenosine salvage III PNP-1 ADA HPRT1 REACTIVE OXYGEN SPECIES DEGRADATION%BIOCYC%DETOX1-PWY-1 reactive oxygen species degradation GPX6 GPX5 GPX8 CAT GPX1 SOD2 SOD3 GPX7 SOD1 ADENOSINE NUCLEOTIDES DEGRADATION%BIOCYC%SALVADEHYPOX-PWY adenosine nucleotides degradation NT5C2 PNP-1 XDH ADA NT5C3A NT5E NT5C1A NT5C1B;NT5C1B-RDH14 ACETONE DEGRADATION III (TO PROPANE-1,2-DIOL)%BIOCYC%PWY-7466 acetone degradation III (to propane-1,2-diol) CYP4X1 CYP2U1 CYP2S1 CYP2A13;CYP2A6;CYP2A7-1 AKR1B15;AKR1B10 CYP2E1 L-CARNITINE BIOSYNTHESIS%BIOCYC%PWY-6100 L-carnitine biosynthesis SHMT1 TMLHE BBOX1 ALDH9A1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY-6362 1D-myo< i>-inositol hexakisphosphate biosynthesis II (mammalian) IPMK INPPL1 ITPK1 OCRL SYNJ2 INPP5B ITPKB ITPKC INPP5A IPPK SYNJ1 INPP5D ITPKA INPP5J INPP5K LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-392 lipoxin biosynthesis ALOX15B GPX4 ALOX5 ALOX15 ALOX12 TRIACYLGLYCEROL DEGRADATION%BIOCYC%LIPAS-PWY triacylglycerol degradation LIPC PNPLA2 PNLIP LIPF LIPE DAGLA LIPG PNPLA3 PNPLA4 LPL CEL DAGLB CMP-N< I>-ACETYLNEURAMINATE BIOSYNTHESIS I (EUKARYOTES)%BIOCYC%PWY-6138 CMP-N< i>-acetylneuraminate biosynthesis I (eukaryotes) NANP CMAS NANS GNE CARDIOLIPIN BIOSYNTHESIS%BIOCYC%PWY-5269 cardiolipin biosynthesis PGS1 PTPMT1 CRLS1 L-DOPA DEGRADATION%BIOCYC%PWY-6334 L-dopa degradation COMT CREATINE BIOSYNTHESIS%BIOCYC%GLYCGREAT-PWY creatine biosynthesis GAMT GATM UDP-&ALPHA;-D-GLUCURONATE BIOSYNTHESIS (FROM UDP-GLUCOSE)%BIOCYC%PWY-7346 UDP-α-D-glucuronate biosynthesis (from UDP-glucose) UGDH GUANOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7226 guanosine deoxyribonucleotides de novo< i> biosynthesis RRM2-1 NME2 NME3 NME5 NME1 NME6 RRM2B RRM1 NME7 NME4-1 FRUCTOSE 2,6-BISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY66-423 fructose 2,6-bisphosphate biosynthesis PFKFB2 PFKFB1 TIGAR PFKFB4 PFKFB3 GERANYLGERANYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5120 geranylgeranyl diphosphate biosynthesis GGPS1 DTMP DE NOVO< I> BIOSYNTHESIS (MITOCHONDRIAL)%BIOCYC%PWY66-385 dTMP de novo< i> biosynthesis (mitochondrial) SHMT2 TYMS DHFR2;DHFR ADENOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7227 adenosine deoxyribonucleotides de novo< i> biosynthesis RRM2-1 NME2 NME3 NME5 NME1 NME6 RRM2B RRM1 NME7 NME4-1 NAD BIOSYNTHESIS FROM 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde NMNAT3 NMNAT2 QPRT NADSYN1 NMNAT1 HEME A< I> BIOSYNTHESIS%BIOCYC%PWY-7856 heme a< i> biosynthesis COX10 MRNA CAPPING I%BIOCYC%PWY-7375 mRNA capping I RNGTT RNMT DI-HOMO-&GAMMA;-LINOLENATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8396 di-homo-γ-linolenate metabolites biosynthesis CBR1-1 PHOSPHATIDYLSERINE BIOSYNTHESIS I%BIOCYC%PWY-7501 phosphatidylserine biosynthesis I PTDSS1 (4Z,7Z,10Z,13Z,16Z)-DOCOSA-4,7,10,13,16-PENTAENOATE BIOSYNTHESIS II (4-DESATURASE)%BIOCYC%PWY-7728 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase) FADS2 ELOVL5 ELOVL7 ELOVL2 HSD17B12 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS I%BIOCYC%PWY-5512 UDP-N< i>-acetyl-D-galactosamine biosynthesis I GALE TERMINAL O< I>-GLYCANS RESIDUES MODIFICATION (VIA TYPE 2 PRECURSOR DISACCHARIDE)%BIOCYC%PWY-7434 terminal O< i>-glycans residues modification (via type 2 precursor disaccharide) GCNT2 GCNT3 ST6GAL2 ST3GAL4 B3GNT2 ST3GAL3 ST6GAL1 B4GALT2 B4GALT3 ST8SIA2 B4GALT1 ETHANOL DEGRADATION III%BIOCYC%PWY66-161 ethanol degradation III ACSS3 ACSS2 ALDH3A2 ALDH2 ACSS1 CYP2E1 ETHANOL DEGRADATION II%BIOCYC%PWY66-21 ethanol degradation II ACSS3 ADH1C;ADH1B;ADH1A ACSS2 ALDH3A2 ALDH2 ACSS1 2-OXOBUTANOATE DEGRADATION%BIOCYC%PWY-5130 2-oxobutanoate degradation DBT BCKDHB MCEE DLD PCCA PCCB MMUT BCKDHA LACTOSE DEGRADATION III%BIOCYC%BGALACT-PWY lactose degradation III GLB1 LCT GLB1L3 NICOTINE DEGRADATION IV%BIOCYC%PWY66-201 nicotine degradation IV CYP4X1 CYP2U1 CYP2S1 CYP2A13;CYP2A6;CYP2A7-1 AOX1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 FMO2 FMO3 FMO4 FMO5 D-GALACTOSE DEGRADATION V (LELOIR PATHWAY)%BIOCYC%PWY66-422 D-galactose degradation V (Leloir pathway) GALM-2 GALK1 PGM2 GALE PGM1 GALT UDP-N< I>-ACETYL-D-GLUCOSAMINE BIOSYNTHESIS II%BIOCYC%UDPNACETYLGALSYN-PWY UDP-N< i>-acetyl-D-glucosamine biosynthesis II GPI HK3 GFPT2 GFPT1 HKDC1 PGM3 GNPNAT1 UAP1 HK2 GCK HK1 L-ALANINE BIOSYNTHESIS%BIOCYC%ALANINE-SYN2-PWY L-alanine biosynthesis GPT GPT2 INOSINE-5'-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6124 inosine-5'-phosphate biosynthesis ATIC ADSL PAICS L-LYSINE DEGRADATION (SACCHAROPINE PATHWAY)%BIOCYC%LYSINE-DEG1-PWY L-lysine degradation (saccharopine pathway) ALDH7A1 AASS AADAT DHTKD1 L-SELENOCYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6281 L-selenocysteine biosynthesis SEPSECS SEPHS1 SEPHS2 PSTK SARS1 SARS2 FATTY ACID &ALPHA;-OXIDATION%BIOCYC%PWY66-387 fatty acid α-oxidation HACL1 SLC27A2 ALDH3A2 ACSM1 PHYH-4 GLUTAMINE BIOSYNTHESIS%BIOCYC%GLNSYN-PWY glutamine biosynthesis GLUL TRANS, TRANS< I>-FARNESYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5123 trans, trans< i>-farnesyl diphosphate biosynthesis GGPS1 FDPS THIO-MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-5963 thio-molybdenum cofactor biosynthesis MOCOS WYBUTOSINE BIOSYNTHESIS%BIOCYC%PWY-7283 wybutosine biosynthesis TYW1;TYW1B TYW3 LCMT2 ANANDAMIDE BIOSYNTHESIS I%BIOCYC%PWY-8051 anandamide biosynthesis I GDE1 PLAAT2 PLAAT5 ENPP2 PLA2G1B NAPEPLD PLAAT1 VALPROATE &BETA;-OXIDATION%BIOCYC%PWY-8182 valproate β-oxidation ACAT2 ACAT1 ACADSB ACSM1 ECHS1 NAD DE NOVO< I> BIOSYNTHESIS%BIOCYC%NADSYN-PWY NAD de novo< i> biosynthesis TDO2 KYNU NMNAT3 AFMID NMNAT2 IDO2 IDO1 QPRT NADSYN1 HAAO NMNAT1 KMO LONG-CHAIN FATTY ACID ACTIVATION%BIOCYC%PWY-5143 long-chain fatty acid activation SLC27A2 ACSL3 ACSBG2 ACSL1 ACSBG1 THIOSULFATE DISPROPORTIONATION IV (RHODANESE)%BIOCYC%PWY-5350 thiosulfate disproportionation IV (rhodanese) TST 2-ARACHIDONOYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-8052 2-arachidonoylglycerol biosynthesis DDHD1 DAGLA PLCB1 DAGLB ARSENIC DETOXIFICATION (MAMMALS)%BIOCYC%PWY-4202 arsenic detoxification (mammals) N6AMT1 PNP-1 TRMT112 SLC34A2 SLC20A2 SLC20A1 AQP9 SLC2A1 LOC100509620;LOC112267859;AQP7 BUPROPION DEGRADATION%BIOCYC%PWY66-241 bupropion degradation CYP4X1 CYP2U1 CYP2S1 CYP2A13;CYP2A6;CYP2A7-1 CYP2B6 PROTEIN S< I>-NITROSYLATION AND DENITROSYLATION%BIOCYC%PWY-7798 protein S< i>-nitrosylation and denitrosylation ADH5 UDP-&ALPHA;-D-GLUCOSE BIOSYNTHESIS I%BIOCYC%PWY-7343 UDP-α-D-glucose biosynthesis I PGM2 PGM1 UGP2 ASPIRIN TRIGGERED RESOLVIN E BIOSYNTHESIS%BIOCYC%PWY66-394 aspirin triggered resolvin E biosynthesis LTA4H PTGS2-2 ALOX5 ORNITHINE DE NOVO < I> BIOSYNTHESIS%BIOCYC%ARGININE-SYN4-PWY ornithine de novo < i> biosynthesis ALDH18A1 SULFATE ACTIVATION FOR SULFONATION%BIOCYC%PWY-5340 sulfate activation for sulfonation PAPSS2 PAPSS1 GDP-MANNOSE BIOSYNTHESIS%BIOCYC%PWY-5659 GDP-mannose biosynthesis GMPPB MPI GPI PMM1 PMM2 GMPPA CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%BIOCYC%PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) SQLE EBP KCNH7 SC5D DHCR24 DHCR7 LSS NSDHL FDFT1 HSD17B7 LBR TM7SF2 UREA CYCLE%BIOCYC%PWY-4984 urea cycle CPS1 ASL ASS1 OTC GLYCINE BETAINE DEGRADATION II (MAMMALIAN)%BIOCYC%PWY-3661-1 glycine betaine degradation II (mammalian) SHMT2 SHMT1 BHMT DMGDH SULFIDE OXIDATION IV (METAZOA)%BIOCYC%PWY-7927 sulfide oxidation IV (metazoa) TST SQOR SUOX HEME BIOSYNTHESIS%BIOCYC%PWY-5920 heme biosynthesis ALAD ALAS2 FECH ALAS1 UROD UROS CPOX HMBS PPOX PROPANOYL COA DEGRADATION I%BIOCYC%PROPIONMET-PWY propanoyl CoA degradation I MCEE PCCA PCCB MMUT L-THREONINE DEGRADATION%BIOCYC%PWY66-428 L-threonine degradation DBT BCKDHB SDSL DLD SDS BCKDHA GUANINE AND GUANOSINE SALVAGE%BIOCYC%PWY-6620 guanine and guanosine salvage PNP-1 HPRT1 CITRULLINE-NITRIC OXIDE CYCLE%BIOCYC%PWY-4983 citrulline-nitric oxide cycle NOS3 NOS1 ASL ASS1 NOS2 SUPERPATHWAY OF METHIONINE DEGRADATION%BIOCYC%PWY-5328 superpathway of methionine degradation DBT BCKDHB MCEE DLD BHMT PCCA BHMT2 PCCB MTR-1 MMUT CDO1 SUOX AHCY MAT2A MAT1A GOT1-1 MAT2B CBS;CBSL CTH BCKDHA TETRAPYRROLE BIOSYNTHESIS%BIOCYC%PWY-5189 tetrapyrrole biosynthesis ALAD ALAS2 ALAS1 UROS HMBS MEVALONATE PATHWAY%BIOCYC%PWY-922 mevalonate pathway IDI1 ACAT2 MVK ACAT1 IDI2 PMVK MVD HMGCR HMGCS2 HMGCS1-1 TAURINE BIOSYNTHESIS II%BIOCYC%PWY-7850 taurine biosynthesis II FMO1 ADO PPCS ASCORBATE RECYCLING (CYTOSOLIC)%BIOCYC%PWY-6370 ascorbate recycling (cytosolic) GSTO1 GLRX DIACYLGLYCEROL AND TRIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%TRIGLSYN-PWY diacylglycerol and triacylglycerol biosynthesis MOGAT3 PLPPR2 PLPPR3 MOGAT1 PLPPR4 DGAT2 DGAT1 PLPP4 MBOAT7 PLPP3 MBOAT1 PLPP2 MBOAT2 PLPP1 ABHD5 LCLAT1 AGPAT2 AGPAT3 AGPAT4 GPAM LPCAT4 GPAT4 LPCAT3 AGPAT5-1 GPAT3 GPAT2 AGPAT1 FLAVIN BIOSYNTHESIS%HUMANCYC%11070 flavin biosynthesis FLAD1 RFK D-MYO< I>-INOSITOL (1,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6366 D-myo< i>-inositol (1,4,5,6)-tetrakisphosphate biosynthesis IPMK ITPK1 MINPP1 CATECHOLAMINE BIOSYNTHESIS%BIOCYC%PWY66-301 catecholamine biosynthesis DDC TH DBH PNMT 7-(3-AMINO-3-CARBOXYPROPYL)-WYOSINE BIOSYNTHESIS%BIOCYC%PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis TYW1;TYW1B TYW3 TAURINE BIOSYNTHESIS I%BIOCYC%PWY-5331 taurine biosynthesis I FMO1 CSAD CDO1 ADENINE AND ADENOSINE SALVAGE I%BIOCYC%P121-PWY adenine and adenosine salvage I APRT MALATE-ASPARTATE SHUTTLE%BIOCYC%MALATE-ASPARTATE-SHUTTLE-PWY malate-aspartate shuttle GOT1-1 MDH1 MDH2 TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_beta_Receptor NCOA1 MAP4K1 FOXO1-1 FOS RHOA PJA1 TGFBR2 NME1 TGFBR3 RBL2 KAT2B PPM1A ZEB2 ZEB1 TFDP1 RBL1 TFDP2 STRAP CRK CD44 ENG ROCK1 HDAC1 LEF1 MAPK8 FZR1 PARD6A STAMBPL1 YAP1-1 MAPK1 E2F5 MAPK3 NFYB NFYC UBE2D3;UBE2D2 AP2B1 MAPK14 PML SKI FKBP1A EIF3I CTNNB1 FOSB BCAR1 RB1 ATF2 SPARC ZFYVE9 UBE2D1 TGFBR1-1 ETS1 STK11 HOXA9 CDC23 CCND1 FNTA MYC CDC27 SNIP1 AKT1 EP300 SOX9 BTRC MAP3K7 TGIF1-1 JUNB VPS39 SKP1 PDK1 NUP214 PRKCG MAP2K3 MEF2A DAXX MEF2C ANAPC7 PRKCB FOXH1 PRKCD RUNX2 CDC25A RBX1 AR EID2 ZFYVE16 PRKAR1B CCNE1 HGS EWSR1 ANAPC4 ANAPC5 TP53 ANAPC1 ATF3 KPNB1 PPP2R2A;PPP2R2D ANAPC2 E2F4-1 SDC2 PXN CUL1 PIK3R2 PIK3R1 FOXO4 FOXO3 ANAPC10 SNX4 CCNB2 SNX1 SNX2 PRKAR2A SMAD2;SMAD3 SKIL SPTBN1 SNX6 MAP2K6 HSPA8 TRAP1 WWTR1 TGFB2 JUN SMAD4 CREBBP JUND TGFB1 SMURF2 SMURF1 TGFB3 VDR STK11IP CAV1 IRF2BP1 NUP153 SMAD6 ESR1 PTK2 SMAD7 DAB2 SNW1 CDK6 COPS5 CDK4 SP1 CDC16 CDK2 CDK1 NFYA-1 DYNLRB2 DYNLRB1 TAB1 DCP1A TP73 CDKN1A CITED1 ARRB2 CTCF BRCA1 UBE2D3-1 ING2 XPO1 XPO4 SUMO1 HNF4A BDNF%IOB%BDNF BDNF FOXO3 SHC4 NTRK1 NTRK2 GSK3B IRS1 IRS2 ELK1 MAPK9 MAPK7 PTK2B PLCG1 RAF1 MAPK8 AKT1 SHC1-1 MAPK1 MAPK3 CCR1%IOB%CCR1 CCR1 PXN ZAP70 GNA14 CCL4L2;CCL4L1;CCL4 CCL8 MAPK14 PTK2 CCL5 CCL23;CCL15 CCL3L1;CCL3L3;CCL3;CCL18 CCL16 CCL26 PRKCD PTK2B CCR1 CCL14 STAT1 SRC NFKB1 MAPK1 RELA CREB3 MAPK3 LEPTIN%IOB%LEPTIN Leptin PIK3R2 PIK3R1 KHDRBS1 ITGB5 SLC2A4 EGFR LEPR ITGAV JAK2 JAK3 SOCS7 PRKCE NCOA3 STAT3 RPS6 PTPN11 RPS6KB1 LEP PDE3A GRB2 MAPK1 MAPK3 MAPK14 PTK2 PRKCD SP1 IRS1 IRS2 THROMBOPOIETIN%IOB%THROMBOPOIETIN Thrombopoietin STAT3 FOXO3 SHC1-1 ATXN2L STAT5B MAP2K2;MAP2K1 MAPK1 MPL GAB1 JAK2 MAPK3 KITRECEPTOR%IOB%KITRECEPTOR KitReceptor SOCS4 SOCS5 STAT5A LYN YES1 MTOR EPOR KITLG TEC FES ATF2 GRAP IL7R MAD2L1 CRK AKT1 MAPK8 EP300 MAPK1 MAPK14 PRKCB GSK3B PLCG1 RAF1 SHC1-1 STAT1 SRC RELA PIK3R2 PIK3R1 JAK2 JAK3 RPS6 JUN PTPN11 RPS6KB1 GRB2 STAT5B PTPRU SH3KBP1 WIPF1 CLTC CBLB CRKL SPRED2 GYS1 SPRED1 RPS6KA1 HRAS MATK PRKCA MITF FGR HCK DOK1 PIK3CA RASA1 KIT TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A SOS1 GRB7 WAS CSF2RB CBL SOCS1 INPP5D EIF4EBP1 ABL1 FYN SOCS6 CCR7%IOB%CCR7 CCR7 FOXO1-1 MAPK14 FOXO3 MTOR CCL21 ADRB2 GSK3B CFL1 CCR7 CCL19 PTK2B PLCG1 RPS6KB1 MAPK8 AKT1 MAPK1 RELA MAPK3 WNT%IOB%WNT Wnt RHOA YES1 GSK3A YWHAB CCND1 PPP2CB;PPP2CA CHD7 DIXDC1 ILK LEF1 PRKACA-1 AKT1 MAPK8 SOX1 CDH1 RAC1 RSPO1 MAP3K7 WNT5A AXIN1 KREMEN1 DKK1 PAX2 SFRP1 PRKCG SFRP2 DAAM1 ARHGEF4 ROR1 ROR2 PI4K2A PRKCB LRP1 CTNNB1 CTBP1 PRKCD LRP5 NLK MESD LRP6 GSK3B FRZB DVL1 DVL2 GPC3 DVL3 PIP5K1B WNT1 WNT2 WNT3 MARK2 WNT4 FZD1 TCF7L2 SMAD1 FZD3 GCKR FZD5 SETDB1 JUP FZD4 CSNK1A1 WNT3A FZD7 FZD6 FZD9 WNT7A FZD8 NFATC2 PPP1CA BCL9 APC PIN1 TCF4 JUN CDK6 PRKCA ARRB2 FAS%IOB%FAS Fas TRAF1 TRAF3 LCK TCP1 TOP1 CSNK2A1;CSNK2A3 MET PLEC PRKN GTF3C3 PARG SATB1 SRF USO1 XIAP GLRX CDC42 CD59 BID PAK2 DEDD ROCK1 EIF4B MBD4 CASP8AP2 DIABLO-1 CFLAR CASP5;CASP4 WEE1 NEDD4 MAPK1 EIF3J BAX MAPK3 FAS PTPN6 PKN2 PKN1 VIM GSK3B MAP2K2;MAP2K1 RASA1 FYN LYN CDC27 AKT1 RAC1 DAXX PRKCD CSNK1A1 PDCD6 CDK11A;CDK11B TIAL1 ARHGDIB MAP3K5 CAST UBE4B PSME3 CSNK2B BTK UBA7 MAX PRKDC STK4 STK3 DEDD2 RIPK1 FADD TIA1 EIF2AK2 BMX EIF2S1 STK24 BCL2 TPTEP2-CSNK1E;CSNK1E BCL2L1 NUMA1 FAF1 HSPB1 FASLG CASP9 CASP7 CASP8 AIFM1 CASP6 CASP10 CASP3 FASTK XPO5 CASP1 CASP2 DFFA RFC1 PARP1 RIPK2 ANXA4 MST1 TRAF2 ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin RHOA YES1 MTOR MET PLEC YWHAB AKT1 RAC1 VIM YWHAE RTKN ITGB4 PIK3CD LAMC2 LAMC1 PIK3CB PIK3CG PRKCD MYLK3 YWHAQ EPHB2 YWHAH AR IRS1 DSP IRS2 DST RPSA YWHAZ ITGA6 COL17A1 LAMA5 CD151 LAMA2 SHC1-1 LAMA3 PIK3R3 MST1R SRC NTN1 PAK1 ERBB2 CLCA1 SFN EIF4E PIK3R2 LAMB3 PIK3R1 LAMB2 BAD ERBIN LAMB1 EIF6 EGFR SMAD2;SMAD3 PTPN11 GRB2 PTK2 PRKCA PIK3CA CASP3 TP73 EIF4EBP1 ABL1 FYN NGF%IOB%NGF NGF ELK1 PRKCI CREB1 DNAJA3 SP1 FRS2 MAP2K2;MAP2K1 MAPK1 MAPK3 HEDGEHOG%IOB%HEDGEHOG Hedgehog DHH HHIP IHH GLI1 GLI3 GLI2 MED12 SHH CCNB1 GRK2 STK36 BOC PRKACA-1 SAP18 MED1 PTCH1 PTCH2 DYRK1A KIF7 KIF27 MED6 MED23 CDK8 SMO GAS1 YWHAE CTNNB1 ARRB2 GM-CSF%IOB%GM-CSF GM-CSF STAT5A LYN YES1 TGFBR3 FES GSK3A AKT1 MAPK8 MAPK1 MAPK3 PTPN6 MAP2K3 MAPK14 BCAR1 GSK3B ELK1 MAPK9 PLCG1 RAF1 SHC1-1 STAT1 PXN PIK3R2 PIK3R1 BAD CREB1 JAK2 MAP2K6 STAT3 RPS6KB1 TGFB1 GRB2 STAT5B MAP2K2;MAP2K1 GAB1 CSF2 SLC2A1 CRKL PARK7 IKBKB DPYSL2 RPS6KA2 RACK1 SPTAN1 PDIA3 PRKCA CHUK SYK VAV1 HCK HNRNPH1 PFN1 EZR STAM2 CSF2RA PRDX3 GANAB CCT5 CSF2RB SH2B2 CBL STAM NFKBIA PTPRC BCL3 CCR9%IOB%CCR9 CCR9 MSN CCR9 FOXO1-1 CD226 ITGB7 MAPK14 MADCAM1 GSK3B EZR RPS6KB1 MAPK8 AKT1 CDH1 CCL25 MAPK1 ITGA4 RDX MAPK3 TIE1 TEK%IOB%TIE1 TEK TIE1 TEK STAT5A MAPK14 BMX PTK2 NOS3 TIE1 DOK2 TEK FES NCK1 ELK1 GRB7 RAF1 AKT1 SHC1-1 STAT5B PAK1 MAP2K2;MAP2K1 MAPK1 MAPK3 CCR5%IOB%CCR5 CCR5 CCL4L2;CCL4L1;CCL4 STAT5A PIK3R1 CCL8 CCL5 CCL3L1;CCL3L3;CCL3;CCL18 CCL26 CCL13;CCL2 CCL11 C5AR1 AFP CCR5 CFL1 PSMA5 CD4 STAT3 AKT1 GRB2 MAPK1 MAPK3 PTPN6 MAPK14 IKBKB CHUK SYK PTK2B CCL14 NFKBIA STAT1 RELA IFN-ALPHA%IOB%IFN-ALPHA IFN-alpha ZAP70 STAT5A FOXO1-1 MTOR MAP2K6 RPS6KA5 ERBB3 CRK STAT4 STAT6 STAT3 EIF4B JAK1 RPS6 IFNAR2 MAP2K4 RPS6KB1 AKT1 STAT2 PLA2G4A TYK2 ARHGAP30 STAT5B PRKCQ IFNAR1 MAP2K3 CRKL PRKCD VAV1 IRS1 IRS2 CBL NFKBIA STAT1 EIF4EBP1 TRAIL%IOB%TRAIL TRAIL CSNK2A1;CSNK2A3 CREB1 XIAP BID AKT1 DIABLO-1 CFLAR PRKDC MAP3K7 MAPK1 BEX3 BAX PRKAA1 MAPK3 TRADD RIPK1 TNFRSF11B FADD BCL10 CYCS-1 CHEK2 MAPK14 TNFSF10 IKBKG BAK1 CTSB MCL1 CTNNB1 APAF1 IRF5 ATM VDAC1 DAP3 CASP7 CASP8 AIFM1 CASP10 CASP3 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CASP1 CASP2 CBL NFKBIA PARP1 SRC NFKB1 RELA TRAF2 NOTCH%IOB%NOTCH Notch KAT2B HDAC1 LEF1 EP300 MAPK1 MAPK3 SKP1 RBX1 GSK3B APP MAML2 MAML1 FHL1 RBPJ LFNG YY1 HEY1 POFUT1 SIN3A CCN3 CIR1 SKP2 PSENEN SMAD1 HES6 NFKB1 TLE1 RELA RING1 FBXW7 SAP30 CUL1 NCOR2 NCOR1 MFNG NUMB MAML3 NOTCH2 NOTCH3 HDAC2 NOTCH1 NOTCH4 PSEN2 SMAD2;SMAD3 DTX1 FURIN JAK2 PSEN1 DLL1 DLL3 APH1A DLL4 MAGEA4;MAGEA1;MAGEA3;MAGEA2;MAGEA2B;MAGEA12;MAGEA6;MAGEA10-MAGEA5;MAGEA5;MAGEA9B;MAGEA9;MAGEA8;MAGEA11 STAT3 NCSTN APH1B SMAD4 HES1 HIVEP3 SPEN JAG2 JAG1 ITCH SNW1 M-CSF%IOB%M-CSF M-CSF STAT5A PIK3R1 STAT3 PTPN11 AKT1 GRB2 STAT5B CSF1R CSF1 INPPL1 ETS2 RIPK1 PSTPIP2 FADD GRAP2 MYO18A VIM TFE3 PTK2 GAB3 DNM1 PRKCD MITF CASP8 PTK2B SHC1-1 CBL INPP5D EGFR1%IOB%EGFR1 EGFR1 EPN3 ACTA2 ELF3 PEAK1 MYH9 DOCK1 GRB14-1 RALB MVP RGS16 ASAP1 ATP1A1 PDLIM1 MARVELD2 REPS2 MTA2 PDLIM4 SNCA EGF SPRY4 PPP2R3A HSPE1 TNIP1 SPRY3 SPRY2 SPRY1 ZPR1 STK11 MYC AKT1 TGIF1-1 PRKCG MAP2K3 PRKCB PRKCD ZFYVE16 HGS TP53 PXN PIK3R2 PIK3R1 SMAD2;SMAD3 JUN JUND CAV1 PTK2 DAB2 SP1 CDK2 CDK1 FOXO1-1 FOS RHOA CRK HDAC1 MAPK8 MAPK1 MAPK3 AP2B1 MAPK14 BCAR1 GSK3B IRS2 ELK1 MAPK9 MAPK7 PTK2B PLCG1 RAF1 SHC1-1 STAT1 SRC NFKB1 RELA KHDRBS1 EGFR JAK2 STAT3 PTPN11 RPS6KB1 GRB2 STAT5B MAP2K2;MAP2K1 GAB1 SH3KBP1 CLTC CBLB CRKL RPS6KA1 HRAS PRKCA DOK1 PIK3CA RASA1 KIT SOS1 GRB7 CBL SOCS1 EIF4EBP1 ABL1 FYN STAT5A LYN MTOR CFL1 GSK3A YWHAB CDH1 RAC1 ARHGEF4 CTBP1 JUP RIPK1 BCL2 CASP9 ANXA4 LCK MET PLEC CDC42 CD59 NEDD4 PTPN6 PKN2 VIM ITGB4 PIK3CD PIK3CB PIK3CG EPHB2 DSP YWHAZ COL17A1 PIK3R3 PAK1 ERBB2 BAD ERBIN PRKCI CREB1 FRS2 GRK2 DYRK1A RPS6KA2 VAV1 PFN1 STAM2 STAM NOS3 DOK2 NCK1 RPS6KA5 ERBB3 JAK1 STAT2 TYK2 PRKAA1 APP ITCH INPPL1 DNM1 USP6NL ATF1 ITSN2 RPL30 TFRC ARAF HNRNPR ENO1 ELK4 EPS8 GJA1 UBASH3B TFG MPRIP ANKS1A SCRIB KIAA1217 PRKAR1A PARD3 PRKD1 RBCK1 KRT6B;KRT6C;KRT6A SERPINB3;SERPINB4-1 IQGAP1 PRKCZ SLC5A5 LDHA ANTXR1-1 MYO6 PLCG2 S100A14 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 S100A11 S100A10 AFAP1L2 RBM3-2 BRAF CYLD TOLLIP TRIP6 PYGB RPLP0 CLTA ARHGAP5 SHB ENSA PLEKHN1 APPL2 APPL1 ANXA1 ANXA2 PGAM1 EPS15L1 PLSCR1 GPRC5A HNRNPA1-1 TKT PHLPP1 AHNAK HTT RPS27L SNX33 AP2S1 FLNB STX4 RPS2 LDLR DDX3X-1 GSN MCF2 HIPK3 DCBLD2 HIPK2 ABI1 FRK CTNND1 ARF4-1 C11orf52 LAPTM4A CDH3 CYSRT1 CDH2 TOM1 GRB10 MAP3K4 MAGI1 PIAS3 DYRK4-1 DYRK1B PRPF4B TOM1L1 TOM1L2 HAT1 PKP2 ADAM9 PKP4 PKP3 PHPT1 PHLDB2 SIRPA;SIRPB1;SIRPG SOCS3 STIP1 ATXN2 ITLN2;ITLN1-2 HNRNPDL ABL2 MAP2K7 SLC38A2 MAP2K5 TNK2 PTPRE CDK5 PTPRA ACTB-1 ALB MAP3K14 RAB5A EIF4G1 BCAR3 ITGB1 CALCOCO2 PTEN PTPN23 PIK3C2B NCK2 SFPQ-1 ACP1 CCDC50 ACTR2 PDCD6IP ITGA3 PKM DSG2 SOS2 SLC25A6 CEBPA CEBPB PRKAA2 WBP2 SRI SLITRK6 CSK RBBP7 CTNNAL1 SH2B1 PTPN18 PTPN1 PPP1R14B PTPN12 BAIAP2 NECTIN1 ERRFI1 AHCYL1 PITPNA ZDHHC5 CBLC RPS6KA3 BAIAP2L1 SNRPD2 TRIM29 TNS4 SLC12A7 EPHB1 RPS10 TNS3 EPHB4 TNS2 EPHB3 TNS1 EPHA4 ACTN1 KRT8 KRT7 KRT5 ACTN4 GAREM1 TAGLN2 RIN1 EPHA1 TLN1 EPHA2 SDC4 ASAP3-1 SDC3 PTTG1IP MYL12B RACGAP1 RALGDS SNX5 VASP INSR PTK6 SPART SMU1 SDC1 CALM1 CALM2 CC2D1A PTPRR HIP1 AP2A1 WASL PTPRK LIMD1 PTPRF OTUD6B GIT1 VAV3 RALBP1-1 MINK1 IL17RD VAV2 CTTN ARHGEF7 ALDOA ARHGEF5 CSTB NEDD9 PRKX SH3BGRL PDZD11 CDV3-1 MAP4K5 EPS15 MPZL1 UBB;UBC MAP3K2 GIT2 MAP3K3 MAP3K1 CAVIN1 CAVIN2 HUWE1 PLEKHA5 PLEKHA6 ATP5F1C CALM3;CALM1 KRT18 KRT17 AXL EPPK1 ESYT1 TJP2 SH3GL3 PRAG1 PEBP1 ARHGAP35 SH3GL2 PDGFRB KIRREL1 APLP2 EEF1A1 ADAM17 EEF1A2 ELMO2 VCL DDX6 DAPP1 PLD1 LPP PLD2 EFNB2 SDCBP CALD1 CASKIN2 CAV2 CRIM1 ARHGAP32 DLG3 ACTR3-1 DYRK3 DOCK4 USP31 FLOT1 FLOT2 KLF11 PDPK1 LSR ARAP1 EPN1 EPN2 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR AndrogenReceptor NCOA1 TOP1 KAT2B HDAC1 APPL1 FOXA1 CALR-1 CCNH BUB1B-PAK6;PAK6 AHR UXT CCND3 KAT5 ZMIZ1 ZMIZ2 PIAS4 DAPK3 PNRC1-1 GTF2F1 GTF2F2 CTNNB1 TLE5 PIAS1 GSN CDC25B CDC37 IL6ST SF1 GSK3B MDM2-2 HSP90B1 BRINP1 PRDX1 BAG1 LPXN PATZ1 XRCC6 POU2F1 UBE2I HSPA5 XRCC5 NONO SRC PIAS3 PA2G4 NR0B2 RELA CDK9 CDK7 RBAK RNF14 TGFB1I1 FHL2 EFCAB6 TRIM68 RAC3 NELFCD PELP1 NCOA2 HSP90AA1 NCOA6 EGFR PRMT1 NCOA4 ARNT ETV5 SENP1 SLC25A4 NCOA3 DDC TMF1 STAT3 COX5B RCHY1 RNF4 NR2C2 NR2C1 PSMC3IP NSD1 NSD2 NRIP1 FLNA SRY PTEN SPDEF SVIL RANBP9 GTF2H1 STUB1 VIP PARK7 RAN RACK1 CEBPA RB1 CCND1 AKT1 EP300 TGIF1-1 DAXX RUNX2 CDC25A AR CCNE1 SIN3A PXN NCOR2 PIK3R1 PPP1CA SMAD2;SMAD3 TCF4 CDK11A;CDK11B HSPA8 MAGEA4;MAGEA1;MAGEA3;MAGEA2;MAGEA2B;MAGEA12;MAGEA6;MAGEA10-MAGEA5;MAGEA5;MAGEA9B;MAGEA9;MAGEA8;MAGEA11 JUN SMAD4 CAV1 ESR1 SP1 HSPB1 CASP7 CASP8 CASP3 CASP1 BRCA1 PRKD1 PARP1 FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 STAT5A LYN CBLB FLT3 ATF1 GAB2 CREB1 ATF2 CEBPA STAT3 JUN AKT1 CBL MAPK1 GAB1 MAPK3 CD40%IOB%CD40 CD40 LCK LYN PIK3R1 MAPK14 PLCG2 IKBKB CHUK SYK FGR JAK3 MAPK9 STAT3 JUN MYC MAPK8 AKT1 NFKBIA MAP2K2;MAP2K1 MAPK1 FYN MAPK3 TNFSF3%IOB%TNFSF3 TNFSF3 TRAF3 TNFRSF1B TNFRSF1A RELB NFKB2 TRAF5 LTA LTBR LTB JUN NFKBIA NFKB1 RELA TRAF2 ID%IOB%ID ID RB1 RBL2 SMAD2;SMAD3 CDK2 ELK4 RBL1 PAX5 ELK1 ELK3 PSMD4 MYOD1 ID1 ID4 ID3 HES1 ID2-1 MYF5 ATF3 TCF7L2 G-CSF%IOB%G-CSF G-CSF SYP SOD1 STAT5A LCK IL3RA LYN POM121;POM121C REL PRKCI SOCS3 JAK2 STAT3 JAK1 PTPN11 AKT1 TYK2 GRB2 STAT5B MAPK1 MAPK3 MAPK14 GAB2 TPTEP2-CSNK1E;CSNK1E RPS6KA1 CDK2 SYK HCK SHC1-1 CBL CSF3 CDKN1B INPP5D STAT1 CSF3R PLA2G1B FTH1 CISH EPO%IOB%EPO EPO STAT5A FOXO1-1 FOXO4 BAD FOXO3 SGK1-1 NOS3 MTOR H2BC21 EPOR HCLS1 BRAF JAK2 RPS6KA5 GSK3A STAT3 JUN PTPN11 AKT1 STAT5B MAP2K2;MAP2K1 MAPK1 MAPK3 GAB1 CRKL SYK VAV1 IRS2 RAF1 SH2B2 IFN-GAMMA%IOB%IFN-GAMMA IFN-gamma STAT5A PLCG2 SPI1 HOXA10 IFNGR1 MAPK11 EGFR IRF1 IRF2 IRF8 JAK2 CRK STAT6 STAT3 JAK1 MAPK8 AKT1 PLA2G4A PRKCQ MAPK1 MAPK3 MAPK14 CRKL CEBPB RAF1 CBL STAT1 TNFSF1%IOB%TNFSF1 TNFSF1 TRAF3 IKBKG TNFRSF1B TNFRSF1A RELB NFKB2 TRAF5 LTA TNFRSF14 LTBR JUN AKT1 NFKBIA NFKB1 RELA TNFALPHA%IOB%TNFALPHA TNFalpha TRAF1 TRAF3 CSNK2A1;CSNK2A3 BID CFLAR PKN1 YWHAE CDC37 YWHAQ YWHAH BRINP1 YWHAZ UBE2I CDK9 CREB1 HSP90AA1 NR2C2 FLNA IKBKB TNFRSF1B RACK1 TNFRSF1A RELB NFKB2 CHUK TRAF5 SYK NFKBIA BCL3 REL RB1 RPL4 SMARCB1 RPS6KA5 RPL8 RPL6 DCAF7 PSMD6 PSMD7 TBK1 PSMD2 AKT1 AKT2 PSMD3 DPF2 BTRC PSMD1 MAP3K7 RPS11 RPS13 SMARCC1 SKP1 SMARCC2 TRADD PSMC2-1 CDC34 KCNQ1 TRIB3 IQGAP2 GLG1 IKBKG CRADD SMARCA4 NKIRAS1 NKIRAS2 PRKCD IKBKE RIPK3 ACTL6A COMMD1 AKAP8 TANK PSMB5 ELP1 LRPPRC KTN1 PSMC3 PSMC1 CCNT1 ZFAND5 TNF FBL PAPOLA KPNA6 TNFRSF8 MAP3K8 KPNA2 AZI2 FBXW7 KPNA3 CUL1 GTF2I UNC5CL FBXW11 USP2 TRPC4AP TXLNA FANCD2 MAPKAPK2 HDAC2 NUPR1 NSMAF FKBP5 COPB2 PSMD12 PSMD13 TNFRSF11A MAP2K6 RASAL2 BAG4 NLRP4 G3BP2 JUN MCC COPS3 CREBBP ALPL TAB3 TAB2 NFKBIE MAP3K11 NFKBIB HSP90AB1 MCM7 CAV1 TNFAIP3 PPP6C BCL7A PPP1R13L NFKBIZ YWHAG PEG3 TRAF7 TRAF4 RASA3 COPS5 POLR1A RPL30 TRAF6 POLR1B POLR1C POLR1D POLR1E MCM5 PFDN2 BIRC2 TAB1 USP11 MTIF2 HDAC6 TIFA POLR2H POLR2L SMARCE1 SPAG9 UBE2D3-1 RNF25 TNIP2 PRC1 GLB1 SUMO1 PDCD2 PRKCZ TBKBP1 HDAC1 MAPK8 MAPK1 MAPK3 UBE2D3;UBE2D2 MAPK14 PML DDX3X-1 MAPK9 STAT1 SRC NFKB1 RELA EGFR MAP2K5 PTPN11 RPS6KB1 MAP3K14 GAB1 DOK1 STAT5A YWHAB MARK2 MAP3K2 MAP3K3 MAP3K1 RIPK1 FADD FAF1 HSPB1 CASP7 CASP8 CASP10 CASP3 CASP2 TRAF2 GDNF%IOB%GDNF GDNF RET PXN CDC25C TH RPS6KA3 PTK2 MET BCAR1 CDK1 DOK1 CRK JUN PTK2B RPS6KB1 RAF1 NFKBIA MAP2K2;MAP2K1 FYN GAB1 TNFSF8%IOB%TNFSF8 TNFSF8 TRAF1 TRAF3 REL AKT1 RELB BCL3 NFKB2 MAPK1 TNFRSF8 NFKB1 RELA CXCR4%IOB%CXCR4 CXCR4 LCK ITK LYN ITGB2 RHOA PLCG2 ICAM1 LCP2 USP14 CXCR4 NCK1 GNAI1 GNA13 GRK6 VCAM1 FYB1 CCR5 LIMK1 CFL1 ESR2 CXCL12 ACKR3-2 CRK YWHAB STAT4 STAT2 RAC1 SDC4 MAPK1 MAPK3 PTPN6 MAP2K3 PRKCD BCAR1 GSK3B ELK1 PTK2B PLCG1 VAV2 STAT1 SRC NFKB1 RELA ZAP70 PXN PIK3R2 PIK3R1 BAD FOXO3 CREB1 EGFR JAK2 JAK3 HSPA8 STAT3 RPS6 PTPN11 RPS6KB1 STAT5B MAP2K2;MAP2K1 CBLB PTK2 CRKL IKBKB ATF1 RPS6KA2 CHUK VAV1 DOK1 RASA1 ARRB2 WAS CBL NFKBIA INPP5D PTPRC FYN CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway CSF2 CREM FASLG AKAP5 CABIN1 PRKACA-1 CHP1 JUNB JUN BATF3 POU2F1 NFATC3 NFATC2 NFATC1 FOS CALM3;CALM1 IL2 IL4 FOSL1 FKBP1A RCAN1 IL3 CD40LG IFNG IL2RA RCAN2 PTGS2-2 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling IL5 COL1A2 CDK4 SP1 SP3 CDK2 DCP1A JUN FOS ATF2 CDKN1A ITGB5 CITED1 SERPINE1 LAMC1 NR3C1 MED15 SIN3B SIN3A MYC HNF4A EP300 AKT1 SNIP1 TGIF1-1 NCOA1 PIAS4 IL10 NCOA2 PIAS3 MEF2C TGIF2 FOXH1 TFE3 FOXO1-1 RUNX3 RUNX2 SAP30 RUNX1 KAT2B AR KAT2A CREB1 RBL1 TFDP1 NCOR1 MYOD1 IRF7 ATF3 E2F4-1 DLX1 HDAC2 CEBPB CBFB HDAC1 MAX CTBP1 FOXG1 GATA3 FOXO4 FOXO3 RBBP4 GSC SMAD2;SMAD3 SAP18 RBBP7 NKX2-5 E2F5 SKIL HSPA8 ZBTB17 CDKN2B CREBBP SMAD4 IFNB1-4 VDR ESR1 SMAD7 SKI IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events CCL13;CCL2 CXCL9 IL23R IL24 ALOX12B PIK3R1 CD3E TNF MPO RELA SOCS3 IL18RAP STAT4 IL12B IL12RB1 JAK2 STAT5A NOS2 STAT1 ITGA3 STAT3 IL18 CXCL2;CXCL3;CXCL1-1 IL19 TYK2 NFKB1 NFKBIA IL6 CD4 PIK3CA IL23A IL1B IL17F IL18R1 IL17A IL2 IFNG SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression RANGAP1 RAN PIAS2 PIAS1 HDAC1 RANBP2 HDAC4 XPO1 UBE2I SUMO1 MDM2-2 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events MAPK3 VAV3 MAP3K1 GSN SYK CHUK MMP2 MMP9 RHOA MAP3K14 BCAR1 CD44 PIK3R1 RELA NFKB1 NFKBIA PIK3CA JUN FOS ROCK2 ITGB3 ILK CDC42 MAPK8 PLAU SPP1 PIP5K1A MAPK1 PTK2B ITGAV RAC1 ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events MAPK3 ACVRL1 BMPR2 TGFBR1-1 ARRB2 ACVR1 SMAD1 TGFB1 TGFB3 CAV1 GDF2 SMAD9 INHBA SMAD5 ACVR2B ACVR2A TGFBR2 PPP1CA TLX2 CSNK2B ID1 ENG FKBP1A SMAD4 MAPK1 SMAD7 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase MAPK3 RHOA BCAR1 PIK3R1 CREB1 RET GRB7 IRS1 SRC PRKACA-1 PIK3CA PXN IRS2 RAP1A JUN GRB10 HRAS PDLIM7 NCK1 GAB1 GFRA1 PTPN11 PRKCA FRS2 PTK2 DOK1 DOK4 GDNF DOK5 RASA1 DOK6 MAPK8 GRB2 SOS1 CRK SHANK3 MAPK1 SHC1-1 RAC1 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events SDCBP MAPK3 CCL5 COL1A2 BSG FGF23 MMP7 MMP1 HGF CASK MMP9 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 FGF19 COL4A4 COL7A1 COL6A2 COL6A1 TGFB1 COL5A2 COL4A3 COL4A6 SDC1 COL4A5 COL6A3 HPSE PPIB FGFR4 MET FGFR3 PRKACA-1 MAPK1 LAMA5 COL11A1 COL11A2 REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation CAMK2B RASGRF2 RASGRF1 RASAL1 RASGRP2 PRKCZ RASGRP1 RASGRP4 RASGRP3 LGALS3 RABGEF1 NRAS RASA4;RASA4B HRAS SYNGAP1 LGALS1 RRAS PLCE1 PRKCB CALM3;CALM1 PRKCE PRKCA DAB2IP RASA2 NF1 KRAS RIN1 SOS2 RASA1 GRB2 SOS1 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling INCENP AURKC AURKB IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events IL5 COL1A2 SP1 COL1A1 PIK3R1 SOCS3 JAK2 STAT5A PIK3CA IL4 ITGB3 CD40LG PIGR SPI1 ETS1 MYB IL13RA2 JAK3 MYBL1 JAK1 IL13RA1 IL4R ARG1 GTF3A OPRM1 FCER2 AKT1 DOK2 IRF4 LTA RETNLB CCL11 IL10 ALOX15 THY1 IL2RG CBL TFF3-1 SOCS1 INPP5D STAT6 CCL17 SOCS5 STAT5B EGR2 MAPK14 PARP14 MTOR AICDA SELP RPS6KB1 BCL6 FES PTPN6 BCL2L1 CCL26 IRS1 CEBPB IRS2 GRB2 SHC1-1 IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K JAK1 MYC AKT1 PIK3R1 IL2RG RELA MTOR RPS6KB1 NFKB1 BCL2L1 PRKCZ SGMS1 UGCG PIK3CA TERT SMPD1 E2F1 HSP90AA1 RPS6 GAB2 LCK IL2RB FOXO3 BCL2 PTPN11 CALM3;CALM1 EIF3A IL2 IL2RA GRB2 SOS1 MYB SHC1-1 JAK3 RAC1 SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling MAP2K2;MAP2K1 NTF3 PAG1 NTRK1 NTRK2 ANGPT1 NOS3 EGF BDNF NTRK3 IGF1 VEGFA PIK3R1 AFDN TEK JAK2 STAT1 IL6 PRKACA-1 PIK3CA NRAS IL2 KRAS IFNG IL2RA JAK3 JAK1 RHOA IL2RG IRS1 HRAS GAB2 LCK GAB1 IL2RB PTPN11 ARHGAP35 IGF1R FRS2 KDR IL6R PDGFRB LMO4 IFNGR1 NGF FRS3 IL6ST GRB2 SOS1 RAF1 SDC2 PDGFB GNAI3 SHC1-1 GNAI1 EGFR NTF4 NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network EP300 NCOA1 RB1 CAMK2D CDKN1B NOTCH1 KDM1A MAML2 MAML1 GATA6 RUNX2 GATA4 JAK2 RBPJ ASCL1 GATA1 AR HIF1A GHR STAT3 YY1 HEY1 HEY2 NCOR1 RBBP8 MYOD1 HES1 SPEN HES6 TLE1 CD4 PARP1 GAA ARNT HDAC1 E2F1 NCOR2 PTF1A CTBP1 NEUROG3 KDR RCAN1 CREBBP MYB INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions ITGA3 ITGB1 ITGAM ITGB4 ITGB2 ITGA2B ITGAE ITGAL ITGAX ITGB8 ITGB7 ITGB6 ITGB3 ITGA4 ITGA2 ITGA1 ITGAD ITGA10 ITGA11 ITGA8 ITGB5 ITGA7 ITGA6 ITGAV ITGA5 ITGA9 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events RAB1A ERCC6L PPP2CB;PPP2CA BUB1B AURKA CDC14B PPP1CB GOLGA2 CDC20 RHOA PAK1 CCNB1 FZR1 PPP2R1A CLSPN FBXO5 ECT2 BTRC BUB1 CENPU NUDC BORA PPP1R12A FBXW11 ODF2 PLK1 TUBG1 CDC25C NDC80 CDC25B SGO1 CENPE TPX2 WEE1 STAG2 KIF2A PRC1 GORASP1 CDK1 KIF20A KIZ TPT1 SPC24 ROCK2 INCENP BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events TP53 ATR CDK2 RBBP8 MRE11 PCNA PRKDC BRCA1 UBE2D3-1 NBN TOPBP1 BARD1 XRCC6 XRCC5 FANCL FANCA FANCC FANCE FANCG FANCF RAD50 RAD51 CCNE1 FANCD2 EWSR1 ATM S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway GNAO1 GNAZ GNA12 S1PR5 GNAI2 RHOA GNAI3 GNAI1 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma NTRK1 YWHAE AKT1 GSK3B YWHAB CAMK2A AGAP2 PIK3R1 CCND1 YWHAQ EPB41L1 SFN PLCG1 YWHAG YWHAH EGR1 TRPC3 BAD PDPK1 STAT5A PRKCD TRPV1 YWHAZ CAMK4 CREB1 SRC PIK3CA NRAS HRAS GAB1 FOXO3 KRAS NGF GRB2 SOS1 SHC1-1 IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 CD3E IL18RAP TGFB1 STAT4 CD86 STAT3 CD80 IL18 PRF1 CD3G CD3D MAPK9 TBX21 IL13 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CD4 ETV5 IRF1 CD28 JUN HLA-DRA CD247 IL18R1 FOS IL2 PIAS2 IFNG IL2RA MAPK8 CREBBP AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling DES BIRC5 TACC1 NCAPD2 AURKA KIF2C VIM RHOA BUB1 NDC80 SGO1 KIF20A CUL3 NCAPG PEBP1 CDCA8 KLHL13 SMC4 CENPA NPM1-2 NCAPH MYLK SMC2 PPP1CC RACGAP1 STMN1 INCENP RASA1 AURKC EVI5 AURKB CBX5 SEPTIN1 NSUN2 KIF23 PPP2R5D KLHL9 NCL-1 PSMA3 NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events MAP2K2;MAP2K1 MAPK3 DAPK1-1 TRIO PITPNA RHOA WASL PAK1 CAMK2A NTN1 BCAR1 AGAP2 FYN PIK3R1 YES1 MYO10 UNC5A DCC PLCG1 UNC5B UNC5C MAP1B ELMO1 DOCK1 SRC PIK3CA NCK1 PTK2 CDC42 MAPK1 RAC1 S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway MAPK3 GNAO1 GNAZ GNA12 S1PR5 GNAI2 RHOA PLCG1 GNA13 S1PR4 CDC42 GNAI3 MAPK1 GNAI1 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events MAP2K2;MAP2K1 PDE3B PIK3CG PIK3R6 MAPK1 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network WNT1 ELANE COL1A2 ZFHX3 CBX4 SP1 CDKN2A ATP2B1 SMARCA2 GSTM1;GSTM2-1 HIPK2 KITLG CDK6 MYF6 CCND1 TAB2 TAB1 ADA MPO CDKN1B GATA1 HES1 CD4 NRAS UBE2I KRAS PTGS2-2 SPI1 CDKN1A ETS1 MYB SIN3A MYC EP300 CCNB1 PIAS3 SLC25A3 LECT2 CLTA LYZ-1 YEATS4 NCOR1 ETS2 MYOD1 PPP3CA CA1 TRIM28 CASP6 ANPEP PIM1 CEBPB TOM1 RAG2 CD34 HRAS MAP3K7 PTCRA H2AZ2;H2AZ1 GATA3 PAX5 SND1 BCL2 CCNA1 MAF ADORA2B TFEC KIT MCM4 ZFPM1 MAD1L1 PPID HSPA8 BIRC3 CSF1R CEBPA CREBBP COPA CEBPD LEF1 IQGAP1 NLK MAT2A SKI EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling MAP2K2;MAP2K1 MAPK3 WASL PAK1 PIK3R1 ROCK1 ITSN1 EFNA5 KALRN RAP1B EFNB2 EFNB1 EFNB3 EPHB2 EPHB1 EPHB4 EPHB3 MAP4K4 DNM1 TF SYNJ1 GRB7 SRC PIK3CA PXN RAP1A NRAS HRAS NCK1 RRAS PTK2 KRAS RASA1 CDC42 GRB2 CRK MAPK1 SHC1-1 RAC1 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway MAP3K1 SYK CHUK AKT1 PIK3R1 PDPK1 MAPK14 CLTC FAIM2 MAPK9 FASLG PIK3CB IKBKB CASP8 SRC CASP10 PIK3CA CASP3 SMPD1 RIPK1 FADD IKBKG BID MAP2K7 MAP2K6 RFC1 CFLAR MAPK10 MAPK11 BTK FAS EZR BIRC2 BIRC3 MAPK8 PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events PLK4 PLK2 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway MAP2K2;MAP2K1 MAPK3 KSR1 CRADD MAP3K1 SPHK2 EIF2AK2 MYC PAWR TRAF2 TNFRSF1A AKT1 EGF PRKRA MADD BAX IGF1 NSMAF RB1 TNF RELA BAD PRKCD MAP4K4 NFKB1 NFKBIA PRKCZ CASP8 SMPD1 RIPK1 FADD BID BCL2 ASAH1 TRADD BIRC3 PDGFA MAPK8 SMPD3 RAF1 CYCS-1 BAG4 AIFM1 MAPK1 CTSD EIF2A MAP2K4 ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling SYK PRKN FYN BLK YES1 MAOB PARK7 PLD1 SLC6A3 KLK6 PLD2 UCHL1 GRK5 SNCA BAD LYN TOR1A PRKCD SNCAIP FGR HCK TH STUB1 CSNK2A1;CSNK2A3 PLCB2 SRC LCK FKBP1A PPP2R5D PTK2B ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway NFKB1 REL NFKBIA IKBKB SYK SRC PIK3CA LCK PIK3R1 ARRB2 RELA BTRC MAPK14 BCL3 RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway RHOA ROCK1 PLD1 CDKN1B PLD2 PPP1R12A SRF PTEN PRKCZ SLC9A1 PARD6A CFL1 PIP5K1B PIP5K1C JUN CCN1 SH3GL2 ITGB1 SCAI MAP2K6 MAP2K3 LIMK2 RDX FOS LIMK1 MSN MRTFA MAPK12 CIT EZR DIAPH1 ROCK2 SLC9A3 ACTA1 MYL2 CDC42 PKN2 MAPK8 PKN1 TLN1 ATF2 F2RL2 PIP5K1A VCL MAP2K4 SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B CDH2 LEPR CAPN1 PRLR CSN2-1 TXN CSK PTPN1 EGF INSR FER TRPV6 LEP PIK3R1 NOX4 SPRY2 LAT SOCS3 JAK2 STAT5A STAT3 TYK2 PIK3CA ITGA2B ITGB3 AKT1 RHOA BCAR1 FYN BLK YES1 CAV1 LYN STAT5B FGR HCK IRS1 SRC LCK DOK1 PDGFRB CSF1R GRB2 CRK PDGFB CSF1 SHC1-1 PRL YBX1 EGFR INS;INS-IGF2 SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events SDCBP MAPK3 FGF23 MMP2 CASK RHOA BAX FGF19 CXCL8 TNFRSF13B EPB41 LAMA1 TGFB1 LAMA3 KNG1 RACK1 CAV2 EPHB2 TRAPPC4 PRKCD FN1 FGFR4 FGFR3 CSF2 SRC PRKACA-1 CASP3 HRAS ITGB1 NF1 EZR ITGA2 RASA1 MAPK8 SDC2 MAPK1 RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway MAP2K2;MAP2K1 MAPK3 NRAS HRAS FOS PRKCB PRKCA KRAS BRAF RAF1 ELK1 MAP3K8 MAPK1 PTPN7 ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network CDK4 CCND1 RB1 CXCL8 SOCS3 NOS2 HBG2;HBG1 HRK ACHE DUSP10 MAPK9 HES1 CSRP2 KAT5 IL6 RUVBL2 CCNA2-1 PDGFRA IL23A JUNB DUSP5 DUSP1 JUN DUSP8 SERPINB5 CUL3 POU2F1 DDIT3 JDP2 MACROH2A1 FOS PPARGC1A TGFB2 JUND MAPK11 COL24A1 GADD45A SELE NF1 IFNG MAPK8 PLAU ATF2 MAPK1 MAPK3 ARG1 EP300 MMP2 MAPK14 CREB1 TH ATF3 BCL2L1 CBFB BRCA1 BCL2 PRKCA ESR1 INS;INS-IGF2 EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling EPHA3 VAV3 NGEF EPHA2 RHOA FYN BLK YES1 ROCK1 CBL PLCG1 EFNA5 LYN PIK3CG PIK3R6 FGR HCK SRC LCK CRKL EPHA5 EPHA4 EPHA7 EPHA6 ARHGEF15 EPHA8 VAV2 CRK EFNA1 EFNA3 EFNA2 CDK5 EPHA1 SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I TNF RELA GATA1 STAT3 YY1 NFKB1 NFKBIA PRKACA-1 NCOR2 RANBP2 HDAC4 XPO1 UBE2I SUMO1 RANGAP1 RAN SIN3B HDAC10 SIN3A HDAC11 CHD4 CHD3 EP300 TNFRSF1A SMG5 PRMT5 SIRT4 SIRT5 SIRT6 SIRT1 SIRT2 SIRT3 WDR77 BTRC PPARG FKBP3 HDAC5 HDAC3 GATA2 HDAC8 SAP30 NR2C1 HDAC9 KAT2B HDAC6 HDAC7 MTA2 MBD3 SMURF1 MBD2 NCOR1 MBD3L2;MBD3L2B;MBD3L5;MBD3L3;MBD3L4 GATAD2B GATAD2A TFCP2 MXD1 HDAC2 HDAC1 MAX RBBP4 SAP18 RBBP7 ZFPM1 CREBBP SMAD7 ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events PLD1 PLD2 ITGA3 CLTC CTNND1 SLC2A4 ASAP2 ADRB2 KLC1 PIP5K1C CDH1 CTNNA1 ITGB1 SPAG9 EXOC7 AVPR2 RALA-1 MAPK8IP3 TSHR DNM2 SCAMP2 NME1 ACAP1 BIN1 ITGA4 AGTR1 ITGA2 EXOC4 ITGA1 EXOC3 CPE ITGA10 CTNNB1 ITGA11 EXOC6 ITGA8 EXOC5 ITGA7 EXOC2 ITGA6 ARF6 ITGAV ITGA5 VAMP3 INS;INS-IGF2 ITGA9 EXOC1 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling ZFAND5 SGK1-1 SKP2 CSNK1G3 USP7 MST1 CDK2 CSNK1D YWHAE RBL2 CAT YWHAB CSNK1G2 CSNK1G1 RALB BCL2L11 YWHAQ CSNK1A1 SOD2 SFN FBXO32 CDKN1B G6PC1 YWHAG TPTEP2-CSNK1E;CSNK1E YWHAH YWHAZ MAPK9 FASLG IKBKB XPO1 MAPK10 GADD45A RAN MAPK8 CHUK EP300 AKT1 CCNB1 SIRT1 FOXO1-1 KAT2B PLK1 BCL6 FOXO4 RALA-1 FOXO3 CREBBP CTNNB1 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway SPHK2 GNAO1 GNAZ GNA12 S1PR5 GNAI2 ABCC1 SPHK1 SGPP1 GNA13 GNA14 SGPL1 S1PR4 GNA15 GNA11 GNAQ S1PR1 S1PR3 GNAI3 S1PR2 GNAI1 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt CHUK YWHAE AKT1 GSK3B YWHAB YWHAQ SFN CDKN1B YWHAG YWHAH FOXO1-1 BAD PDPK1 YWHAZ MTOR GSK3A MAPKAP1 CASP9 AKT2 AKT3 BCL2L1 MLST8 RICTOR SRC SLC2A4 PRKACA-1 KPNA1 MAP3K5 TBC1D4 HSP90AA1 PRKDC FOXO4 FOXO3 RAF1 CDKN1A E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction AKT1 RHOA PIK3R1 CCND1 AFDN RAP1B CTNND1 SRC PIK3CA CYFIP2 RAP1A PIP5K1C NCKAP1 CDH1 CTNNA1 WASF2 AP1M1 JUP KLHL20 TJP1 ENAH ITGAE TIAM1 DLG1 CTTN NME1 ABI1 ITGB7 RAPGEF1 CDC42 CTNNB1 VAV2 CRK IQGAP1 ARF6 RAC1 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family GRK2 SMO BOC GAS1 PIK3CA CDON AKT1 PIK3R1 TGFB2 ARRB2 LRPAP1 STIL DHH PTCH1 HHIP PTCH2 IHH LRP2 PTHLH GLI2 SHH HHAT POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle PLK4 PLK3 PLK2 PLK1 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway STAT5A STAT3 MAPK9 CYFIP2 JUN NCKAP1 WASF2 MAP2K7 MAP2K6 ABI1 RACGAP1 MAPK8 ATF2 PIP5K1A RAC1 MAP2K4 MAP3K1 WASF1-1 NCF1 NCF2 ARPC1B PAK1 ARHGAP5 BCAR1 ARHGDIA ACTR2 CYBB CYBA NOXO1 IQGAP3 PAK2 ARPC4 ARPC5 BAIAP2 ARPC2 ABI2 ARPC3 MAPK14 NOXA1 ACTR3-1 MAP3K11 NOX1 PLCB2 CFL1 PIP5K1B PIP5K1C CDH1 CTNNA1 MAP2K3 LIMK1 CTNNB1 CRK IQGAP1 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones ARR3 RPE65 GRK1 RDH12 GNAT2 RGS9BP GRK7 RDH5 GNB3 CNGB3 PDE6C LRAT CNGA3 GNB5 RGS9 LOC118142757;GUCA1A SLC24A2 GUCY2D PDE6H GUCA1C REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity APC VAV3 SPATA13 NGEF ARHGEF7 ARHGEF6 ARHGDIA ITSN1 PLCG1 ITSN2 DOCK6 BCAR3 NME1 ARHGEF25 DOCK9 ARHGAP1 RACGAP1 ARHGAP17 FGD1 CDC42 DOCK10 DOCK11 MCF2L VAV2 GIT1 FARP2 RALBP1-1 MCF2 DNMBP HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network SP1 FLT1 CITED2 EPO EP300 EPAS1 SLC2A1 POU5F1;POU5F1B ELOC-1 PGK1 VEGFA ELOB SIRT1 VHL HIF1AN EGLN1 EGLN3 EGLN2 SLC11A2 MMP14 ADORA2A APEX1 BHLHE40 EIF3E FXN ABCG2 ELK1 ARNT KDR CREBBP ETS1 EFNA1 SERPINE1 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity SMARCA2 GSK3B EGR1 RACK1 EHMT2 ZMIZ2 TRIM24 KLK3;KLK2 SMARCC1 SENP1 PDE9A TMPRSS2 KAT5 NR2C2 HOXB13 RCHY1 RXRB RXRA SRY JUN RXRG SPDEF POU2F1 SMARCE1 MAP2K6 NR0B1 APPBP2 DNAJA1-1 CARM1 MDM2-2 MAPK8 MAP2K4 NR3C1 EP300 NCOA1 SIRT1 NCOA2 FOXO1-1 GATA2 NR2C1 KAT2B MAPK14 AR HDAC7 REL SRC HDAC1 HSP90AA1 PKN1 CEBPA CREBBP PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway JAK1 SRF PIK3CA PDGFRA JUN PIK3R1 FOS CAV3 SHB PLCG1 SHF CRKL RAPGEF1 CAV1 GRB2 SOS1 ELK1 CRK SHC1-1 CSNK2A1;CSNK2A3 ITGAV SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events FGF23 SRC CASK FYN FGF19 CXCL8 CTTN PSENEN NCAN SDC3 PSEN1 PTN MC4R APH1A POMC NCSTN FGFR4 APH1B AGRP FGFR3 EGFR SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta ELK4 TP53 RPS6KA4 RPS6KA5 MKNK1 EIF4EBP1 EIF4E MEF2A KRT8 PLA2G4A MITF USF1 KRT19 MAPKAPK3 MAPKAPK2 HBP1 MEF2C MAPKAPK5 RAB5A ATF6 NOS2 MAPK14 CREB1 SLC9A1 CEBPB JUN DDIT3 PPARGC1A MAPK11 PTGS2-2 ATF2 ATF1 ESR1 GDI1 HSPB1 ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events BCAR1 IGSF8 CD81 THBS2 DOCK1 THBS1 PRKACB-1 ADAM28 MDK FN1 CD14 YWHAZ JAM2 VCAM1 JAML PRKAR1B PRKAR1A PTPRA SRC PRKACA-1 PXN ITGB1 PTK2 ABI1 ITGA4 TLN1 SPP1 CRK GIT1 PTK2B ARF6 RAC1 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network WNT1 LRP5 FZD10 LRP6 WIF1 RSPO1 WNT2 WNT3 CTHRC1 FZD1 FZD2 FZD5 IGFBP4 RYK-1 FZD4 WNT3A FZD7 WNT7B FZD6 ATP6AP2 WNT5A KREMEN1 FZD9 FZD8 WNT7A KREMEN2 DKK1 ROR2 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network TIMP1 TP53 IL5 EDN1 COL1A2 ELF1 DMTF1 SP1 NTS CDKN2A MMP1 BAG1 PENK CCL13;CCL2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E TCF7L2 AGT FOSL2 COPS5 CCND1 BCL2L11 FABP4 MAFG TRIP6 CXCL8 FOSB CDKN1B EGR1 HIF1A CSF2 IL6 JUNB DUSP1 JUN NFATC3 NFATC2 NFATC1 FOS JUND IL2 IL4 FOSL1 IFNG PLAU ATF2 ETS1 MYB NR3C1 MYC EP300 MMP9 IL10 TGFB1 GATA2 CREB1 TH ATF3 PTEN CDK1 CBFB CCN1 MAF ACTA1 CTNNB1 CRTC1 DMP1 MT2A ESR1 GJA1 NPPA IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events SDCBP IL5 PIK3CA PIM1 PIK3R1 PTPN11 CISH IL5RA CSF2RB LYN STAT5B JAK2 STAT5A GRB2 INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling ARHGEF7 ARHGEF6 AURKA AKT1 GSK3B CCND1 RUVBL1 NCK2 ILKAP PPP1R12A TNS1 PPP1R14A GIT2 PPP1R14B PPP1R14C ACTN1 CREB1 RHOG PARVA PARVB CKAP5 ZEB1 LIMS4;LIMS1 PARVG RUVBL2 RICTOR NACA PARP1 CDC37 PXN ZYX TACC3 JUN SNAI1 HSP90AA1 ELMO2 LIMS2 XPO1 DIAPH1 ILK CDC42 CTNNB1 IQGAP1 RAC1 N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events CDH2 GSN PTPN1 RHOA FER PIK3R1 ROCK1 PLCG1 LRP5 CTNND1 PIK3CA PIP5K1C CTNNA1 GRIA2 DAGLA JUP DCTN1 MAPRE1-1 CNR1 PTPN11 CALM3;CALM1 KIF5B CAMK2G AXIN1 CTTN GAP43 DAGLB FGFR1 MYL2 CDC42 MAPK8 CTNNB1 GJA1 RAC1 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor RARA RARB PPARA PPARD NCOA1 TNF PPARG TGFB1 RPS6KB1 RXRB RXRA NCOR2 RXRG BCL2 RARG THRB THRA FAM120B ABCA1 SREBF1 MED1 VDR NR1H2 NR1H4 NR1H3 NR4A1 P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network TP63 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network CCND1 STAT5A NCOR2 JUN HDAC4 NR0B1 MED1 CTSD MYC COL18A1 CHUK CALCOCO1 EP300 CD82 MPG SRA1 PHB2 NCOA1 DDX17 PDIA2 NCOA2 DSCAM NCOA3 AP1B1 DDX54 AXIN2 SAFB LCOR PGR TRIM59 NCOA7 TFF1 PRDM15 MTA1 SET-1 HSF2 NRIP1 APBB1 NCOR1 NDUFV3 ATP5PF XBP1 KLRC4;KLRC3;KLRC2;KLRC1 ABCA3 GREB1 C3-1 CEBPB POU4F1 NR0B2 HDAC1 ANP32A;ANP32D POU4F2 ESR2 SOD1 PCNA UBA3 EBAG9 BRCA1 LMO4 SMAD4 PRL ESR1 ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling ELF1 ANGPT1 NOS3 PIK3R1 TEK TNF RELA STAT5A FN1 ELK1 NFKB1 PIK3CA ITGB1 MAPK8 CDKN1A ETS1 MAPK1 ITGA5 RAC1 MAPK3 MMP2 AKT1 DOK2 PAK1 FYN PLD2 FOXO1-1 STAT5B MAPK14 RPS6KB1 FES GRB7 PXN NCK1 FGF2 F2 PTPN11 ELF2 GRB14-1 PLG PTK2 ANGPT4 ANGPT2 BMX AGTR1 TNIP2 RASA1 GRB2 CRK SHC1-1 DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells MAP2K2;MAP2K1 TNFRSF9 CD8B;CD8B2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CD3E TNF STAT4 EGR1 BRAF ELK1 PTPN7 PRF1 CD3G CD3D MAPK9 FASLG JUNB JUN NRAS CD247 NFATC3 NFATC2 NFATC1 FOS PRKCB CALM3;CALM1 PRKCE IL2 FOSL1 KRAS IFNG IL2RA MAPK8 MAPK1 MAPK3 IL2RG HRAS IL2RB PRKCA TNFRSF4 B2M GZMH;GZMB-1 IFNAR2 RAF1 EOMES TNFRSF18 CD8A PRKCQ IFNAR1 EGR4 SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase MAP2K2;MAP2K1 CAPN2 ARHGEF7 SH3GL1 ARHGEF11 ARHGEF28 ASAP1 PTPN21-1 ARHGAP26 KLF8 CCND1 PIK3R1 PLCG1 RAP1B NCK2 GIT2 BRAF ACTN1 MAPK9 PIK3CA JUN ITGB1 RRAS RAPGEF1 ROCK2 MAPK8 ETS1 ITGB5 MAPK1 ITGAV ITGA5 RAC1 MAP2K4 RHOA WASL PAK1 BCAR1 FYN YES1 ELMO1 DOCK1 GRB7 SRC PXN RAP1A NCK1 MAPK8IP3 ARHGAP35 PTK2 BMX ACTA1 RASA1 GRB2 SOS1 TLN1 RAF1 CRK VCL ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions LAMA1 LAMA3 LAMB3 LAMA2 ITGB4 LAMB2 LAMA5 LAMC2 ITGA6 LAMB1 LAMC1 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway ATR BLM WDR48 BTRC CENPS-CORT;CORT;CENPS FAAP24 BRCA2 BRIP1 LOC105377022;FANCB CHEK1 FBXW11 USP1 ATRIP FAAP100 FANCI RFC5 RFC3 RFC4 FANCM RMI1 HES1 RFC2 TOP3A XRCC3 RPA1 RPA2 HUS1 PALB2 UBE2T RAD17 RAD1 MRE11 FAN1 RAD9A BRCA1 NBN TOPBP1 FANCL FANCA FANCC FANCE FANCG FANCF RAD50 FANCD2 ATM VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms KRT5 POU2F2 IL1A ITCH TP63 CDKN2A AXL FASN RAB38 GSK3B FOSL2 COL5A1 HBP1 ADA SFN NOTCH1 BRCA2 RACK1 RUNX1 ITGA3 HES1 MRE11 TOP2A DLX5 RRAD STXBP4 MDM2-2 DLX6 TBXT SEC14L2 CCNB2 YAP1-1 PERP BDKRB2 KRT16;KRT14 HELLS TCF7L1 FBXW7 CEBPD IGFBP3 VDR ADRM1 WWP1 PPP2R5A NRG1 ATM CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis TNF PRF1 CASP9 CASP8 CASP10 PARP1 CASP3 RIPK1 BID BIRC2 TRADD SREBF1 CYCS-1 CRADD MAP3K1 GSN TRAF2 VIM TNFRSF1A APP NUMA1 MADD LMNB2 BAX LMNB1 PIDD1 CASP7 SLK CFL2 ARHGDIB CASP1 CASP2 SPTAN1 DFFB DFFA APAF1 GAS2 TOP1 SATB1 XIAP LMNA TFAP2A DIABLO-1 CASP5;CASP4 KRT18 CASP6 BCL2 LIMK1 PTK2 ACTA1 BIRC3 GZMH;GZMB-1 IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events CXCL8 REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity VAV3 SPATA13 NGEF ARHGEF7 ARHGEF6 TRIO ARHGDIA KALRN ELMO1 DOCK1 RASGRF2 ARHGAP9 RASGRF1 RAP1GDS1 PREX2 EPS8 ABR PREX1 CHN2 CHN1 DEF6 VAV1 TIAM2 BCR ARHGEF2 DOCK2 TIAM1 DOCK6 ABI1 ARHGEF25 ARHGAP1 RACGAP1 ARHGAP17 SOS1 VAV2 RALBP1-1 MCF2 RAC1 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling MST1 MMP2 MMP9 RHOA THY1 TNF ROCK1 RAP1B JAM2 HCK SELP NFKB1 IL6 RAP1A ITGAM SELPLG ITGB2 LRP1 PLAT MST1R PLG AGER ICAM1 HMGB1-1 CCN2 APOB JAM3 PLAUR PLAU TLN1 ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway MAPK3 RHOA PLD1 TIAM1 KALRN NME1 PLD2 PLAUR ARF1 RAB11A RAB11FIP3 PIP5K1A MAPK1 ARF6 RAC1 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells LAT2 MAP2K2;MAP2K1 HCLS1 LCP2 MS4A2 PLPP1 PLA2G1B KLRG1 PTPN13 FER PIK3R1 LAT RELA PLCG1 SPHK1 S1PR1 NFKB1 IKBKB PIK3CA DUSP1 JUN IKBKG MAP2K7 NFATC2 FOS PRKCB BTK MAPK8 MAPK1 MAP2K4 MAPK3 MAP3K1 SYK CHUK AKT1 PLA2G4A FYN CBL PAK2 PLD2 INPP5D LYN PXN VAV1 HRAS GAB2 PTPN11 PTK2 DOK1 RASA1 GRB2 SOS1 RAF1 ITK WIPF1 SHC1-1 CBLB FCER1A FCER1G S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway MAPK3 GNAO1 GNAZ FLT1 GNA12 GNAI2 AKT1 CXCR4 RHOA VEGFA GNA13 GNA14 JAK2 GNA15 GNA11 GNAQ S1PR3 AKT3 SRC PDGFRB PDGFB GNAI3 MAPK1 GNAI1 RAC1 A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling PTK2 ITGB7 ITGA4 PXN RHOA MADCAM1 ITGB1 VCAM1 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling MAP2K2;MAP2K1 NTF3 NTRK1 NTRK2 BDNF NTRK3 PRKCI DYNLT1 CCND1 MATK PIK3R1 SQSTM1 FAIM SHC2 SHC3 PLCG1 RGS19 MAGED1 NEDD4L RAP1B ABL1 NGFR ARHGAP32 RIT1 RIT2 EHD4 GIPC1 STAT3 DNAJA3 RHOG DNM1 RASGRF1 PRKCZ PIK3CA NRAS TIAM1 CRKL RAPGEF1 KRAS CDC42 MAPK1 RAC1 MAPK3 RHOA ELMO1 DOCK1 RAP1A HRAS GAB2 GAB1 PTPN11 FRS2 NGF RASA1 FRS3 GRB2 SOS1 MCF2L CRK SHC1-1 NTF4 CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events SGK1-1 SYK RHOA FYN BLK PIK3R1 YES1 LAT PLCG1 INPP5D LYN PDPK1 PIK3CG PIK3R6 FGR HCK INPPL1 DAPP1 CYTH3 CYTH2 BLNK PIK3CB PLCG2 PTEN CYTH1 PLEKHA1 SRC PLEKHA2 PIK3CA ARAP3 ADAP1 RAP1A ZAP70 NRAS HSP90AA1 ARF5 HRAS LCK FOXO3 BTK KRAS ARF1 ITK ARF6 RAC1 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events MAPK3 PRLR ITCH FYN PIK3R1 TAB2 JAK2 STAT5B STAT5A NCOR1 PIK3CB PIK3CA ERBB4 ERBB2 LRIG1 WWOX NRG2 GRIN2B MDM2-2 EREG BTC ADAM17 NRG3 DLG4 YAP1-1 NRG4 NEDD4 HBEGF GRB2 MAPK1 SHC1-1 PRL WWP1 NRG1 GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events MAP2K2;MAP2K1 MAPK3 SYK CCL13;CCL2 PIK3R1 CISH CSF2RB INPP5D PRKACB-1 JAK2 LYN STAT5B STAT5A STAT1 YWHAZ STAT3 CSF2 IKBKB PRKACA-1 PIK3CA PIM1 NRAS HRAS GAB2 FOS PTPN11 KRAS CSF2RA OSM GRB2 IRF8 SOS1 RAF1 MAPK1 SHC1-1 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta MAPK12 STMN1 PKN1 EEF2K MAP2K3 MAP3K20 MAP2K6 CCND1 MAPT SNTA1 MAPK13 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction LPP AQP3 LIMA1 EPHA2 MYO6 MGAT3 STX4 VASP HGF EGF PLEKHA7 RHOA CAMSAP3 KIFC3 IGF1 NECTIN2 AFDN ROCK1 ACTN1 MET CTNND1 ZYX CYFIP2 PIP5K1C NCKAP1 CDH1 CTNNA1 NCK1 ENAH IGF1R ABI1 DIAPH1 MYL2 EXOC4 EXOC3 CTNNB1 GIT1 EFNA1 VCL ARF6 EGFR AQP5 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 MAP2K2;MAP2K1 FLT1 NOS3 VEGFA PIK3R1 ROCK1 PLCG1 NCK2 PDPK1 PRKCD BRAF PRKACA-1 PIK3CA MAP2K6 PRKCB CALM3;CALM1 MAPK11 SHB ITGB3 NEDD4 CDC42 MAPK1 PTK2B ITGAV MAPK3 AKT1 RHOA HSP90AB1 FYN PTPRJ CDH5 MAPKAPK2 MYOF HGS CBL AKAP1 CAMKK2 PAK2 VTN PTPN2 CAV1 FBXW11 MAPK14 FES PTPN6 SRC PXN GRB10 HSP90AA1 CTNNA1 NCK1 MAP2K3 GAB1 PTPN11 PRKCA DNM2 KDR PTK2 ARF1 GRB2 RAF1 CTNNB1 VCL IQGAP1 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation TP53 TAF4B SERPINI1 CDK4 PFKM EIF4G1 ID2-1 SLC2A1 RUVBL1 KAT5 RUVBL2 SNAI1 NPM1-2 FOSL1 NCL-1 BIRC5 MYC EIF4E EP300 MMP9 BAX CCNB1 EIF4A1 TFRC TRRAP ENO1 BMI1 GAPDH-1 MTA1 CCND2 KAT2A PEG10 UBTF RCC1 TK1 DDX18 CAD ACTL6A NME2 CDC25A SUPT3H PIM1 SUPT7L TERT BCAT1 PTMA HSP90AA1 MAX SHMT1 TAF9 RPL11 IREB2 ODC1 CDCA7 MTDH NBN HSPD1 PRDX3 SMAD2;SMAD3 LDHA NME1 MYCT1 PDCD10 PMAIP1 E2F3 TAF12 HSPA4 TAF10 CREBBP HUWE1 SMAD4 EIF2S1 LIN28B GPAM POLR3D RIOX2 NDUFAF2 REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta DUSP16 PAK3 PRKG1 MAP3K3 PAK1 TRAF6 CCM2 RALB FYN MAP3K12 BLK YES1 TAB1 PAK2 LYN MAPK14 FGR HCK DUSP10 SRC RIPK1 DUSP1 DUSP8 MAP2K6 MAP2K3 LCK RALA-1 MAPK11 CDC42 RAC1 MAP2K4 SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) MAP2K2;MAP2K1 EPO GSK3B KITLG FER PTPRO MATK PIK3R1 PIK3C2B SPRED2 SPRED1 GRAP2 MAP4K1 STAP1 SH2B3 SH2B2 BAD EPOR JAK2 PDPK1 TEC STAT5A SNAI2 STAT1 STAT3 PIK3CA CRKL MAPK8 MAPK3 AKT1 MITF CBL SOCS1 LYN RPS6KB1 PTPN6 PTEN GRB10 VAV1 HRAS GAB1 FOXO3 BCL2 PTPN11 DOK1 KIT GRB2 SOS1 RAF1 CREBBP SHC1-1 GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network MAPK9 PTCH1 BMP4 MAPK8 FGF7 GPC3 FURIN SHH ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events BCAR1 VEGFA NOS2 FN1 VCAM1 TNC F13A1 SAT1 CSF2 TGM2 KCNJ15 VEGFC VEGFD ADAM2 SRC ADAM15 PXN ADAM12 ADAM8 PAOX ITGB1 CSF2RA SPP1 RAC1 ITGA9 DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining DCLRE1C XRCC4 POLM PNKP PRKDC LIG4 DNTT APTX APLF POLL NHEJ1 XRCC6 XRCC5 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) MAP2K2;MAP2K1 APC HGF PTPN1 PRKCI PIK3R1 PLCG1 RAP1B EGR1 NCK2 BAD PDPK1 MET INPPL1 AKT2 MLST8 PRKCZ PIK3CA JUN SNAI1 SH3KBP1 CRKL RPTOR RAPGEF1 DEPTOR AKT1S1 NUMB ARHGEF4 CDC42 RIN2 MAPK8 KPNB1 EPS15 ETS1 PAK4 MAPK1 RANBP9 RANBP10 MUC20 RAC1 MAP2K4 MAPK3 MAP3K1 EIF4EBP1 EIF4E AKT1 RHOA WASL PAK1 BCAR1 PTPRJ HGS CBL RAB5A PAK2 INPP5D PTPN2 MTOR SRC PARD6A PXN RAP1A CDH1 HRAS SH3GL2 CTNNA1 GAB2 NCK1 GAB1 PTPN11 PTK2 GRB2 SOS1 RAF1 CTNNB1 CRK F2RL2 SHC1-1 ARF6 EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway MAPK3 GSN PTPN1 EGF WASL PAK1 PIK3R1 PLCG1 NCK2 STAT1 STAT3 PTPN6 PIK3CB SRC PIK3CA PIP5K1C NRAS HRAS NCK1 GAB1 PTPN11 PTK2 KRAS RASA1 GRB2 SOS1 TLN1 GNAI3 MAPK1 SHC1-1 GNAI1 EGFR PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events AKAP13 GRK3 SNX1 GNAO1 GNAZ GNG2 SNX2 GNA12 PRKCG GNAI2 VASP TRPC6 NOS3 F2R RHOA PLCB3 GNB1 ARHGEF1 ARHGDIA PLCB1 PIK3R1 ROCK1 GNA13 GNA14 GNA15 PRKCD GNA11 GNAQ DNM1 PLCB2 PIK3CA ZYX PRKCB F2 PRKCA DNM2 ROCK2 MYL2 PKN1 F2RL2 GNAI3 GNAI1 ARRB1 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events SDCBP CCL5 MMP9 CXCR4 RHOA SDC4 TFPI FGF6 CXCL12 TNFRSF13B LAMA1 LAMA3 THBS1 PRKCD MDK FN1 GIPC1 ACTN1 TNC ADAM12 ITGB1 FGF2 F2 FZD7 PRKCA DNM2 PLG PTK2 FGFR1 ITGA5 RAC1 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway TP53 ATR SKP2 CSNK1G3 USP7 CDKN2A CDK2 CSNK1D GSK3B HIPK2 CSNK1G2 CSNK1G1 CSNK1A1 TPTEP2-CSNK1E;CSNK1E ABL1 CHEK1 PRKCD YY1 MAPK9 KAT5 CCNA2-1 RCHY1 MDM2-2 MAPK8 PPP2CB;PPP2CA EP300 AKT1 PRMT5 DYRK2 CSE1L SETD7 UBE2D1 RASSF1 PPP1R13L CHEK2 KAT8 KMT5A KAT2B MAPK14 DAXX RPL23 FBXO11 SMYD2-1 PPM1D PTPA COP1 E4F1 RPL5-1 TRIM28 TTC5 CCNG1 PIN1 MDM4 RPL11 CREBBP HUWE1 ATM CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes IL5 CDK4 ITCH PTPN1 IRF4 TNF CXCL8 PPARG EGR1 EGR2 CSF2 CREM FASLG TBX21 CASP3 DGKA JUNB SLC3A2 E2F1 JUN PTPRK BATF3 IKZF1 POU2F1 GBP2;GBP3;GBP1 NFATC3 GATA3 CTLA4 NFATC2 EGR3 NFATC1 FOS FOXP3 CALM3;CALM1 RNF128 IL2 MAF IL4 FOSL1 IL3 CD40LG IFNG IL2RA PTGS2-2 CBLB PRKCQ EGR4 E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events CDH1 CTNNB1 JUP S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway MAPK3 GNAO1 GNAZ IRS1 GNA12 GNAI2 JUN RHOA PAK1 FOS CDH5 GNA13 GNA14 GNA15 MAPK14 MAPK8 GNA11 GNAQ ELK1 GNAI3 MAPK1 S1PR2 GNAI1 RAC1 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling MAP2K2;MAP2K1 MAPK3 GNAO1 GNAZ GNG2 GNAI2 AKT1 PLCB3 GNB1 PLCB1 PIK3R1 PLCG1 AR CREB1 PLCB2 PLCG2 SRC PIK3CA HRAS FOS PELP1 GNRH1 PTK2 SHBG CDC42 RAF1 GNAI3 MAPK1 GNAI1 RAC1 PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events TP53 PLK3 CHEK2 CDC25C CCNE1 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 COL1A2 DMTF1 SP1 CDKN2A MMP1 EP300 NOS3 MMP2 CCL13;CCL2 MMP9 FOSL2 CCND1 CXCL8 LAMA3 IL6 CCNA2-1 JUNB JUN NFATC3 NFATC2 ITGB4 NFATC1 JUND FOSL1 TXLNG THBD HMOX1 LIF USF2 PLAUR DCN MGP PLAU IVL ATF4 GJA1 ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway TP53BP1 SMC1A TERF2 UBE2N YWHAB BLM ABL1 CHEK2 CDC25C COP1 RBBP8 TOP3A KAT5 TRIM28 CDC25A DCLRE1C RAD17 CTBP1 BID XRCC4 MRE11 RAD9A BRCA1 MDM2-2 NBN RAD50 MDC1 ABRAXAS1 RNF8 FANCD2 SMC3 UIMC1 ATM HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha CRADD TRAF1 CHUK TRAF2 TNFRSF1A MAP3K14 CASP7 TNF RELA CASP2 APAF1 DAXX CASP9 NFKB1 FASLG NFKBIA CASP8 CASP6 CASP3 MAP3K5 RIPK1 FADD CD247 BID MAP2K7 CFLAR BCL2 FAS TRADD BIRC3 MAPK8 CYCS-1 BAG4 ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling IKBKB CHUK BGN LY96 IRAK4 TICAM1 RHOA IKBKG TIRAP TLR1 VCAN SAA2;SAA1 IRAK1 IRAK2 HSPD1 TLR6 TLR4 S100A9 MYD88 HMGB1-1 S100A8 TLR3 TLR2 CD14 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events JAK1 TNF TGFB1 STAT4 IL12B IL12RB1 EBI3 JAK2 IL27 STAT5A IL27RA IL12A STAT1 IL12RB2 STAT2 STAT3 IL18 TYK2 TBX21 IL6 IL1B IL17A GATA3 IL2 IFNG IL6ST P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling TP53 NTF3 NTRK1 MMP7 YWHAE BDNF TRAF6 PRKCI PIK3R1 BCL2L11 SQSTM1 IRAK1 MAGED1 MYD88 NGFR BAD FURIN PRDM4 ZNF274;ZNF74 SMPD2 CASP9 RIPK2 NSMCE3 MAPK9 MMP3 IKBKB OMG PRKCZ RHOC RHOB PIK3CA CASP3 MAG BEX3 MAGEH1 IKBKG RTN4 NDN LINGO1 SORT1 BEX2;BEX1 MAPK10 ADAM17 PSENEN BIRC2 PSEN1 APH1A MAPK8 CYCS-1 NCSTN APH1B RAC1 CHUK APP AKT1 RHOA ARHGDIA APAF1 PRKACB-1 XIAP DIABLO-1 CASP6 E2F1 PLG NGF BIRC3 SHC1-1 NTF4 CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway APC LRP6 PIP5K1B GSK3B CUL3 FZD5 CSNK1G1 RANBP3 WNT3A KLHL12 NKD2 DVL1 AXIN1 DVL2 DVL3 PI4K2A CAV1 CTNNB1 GSK3A PPP2R5A FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway CDH2 MAPK3 FGF23 AKT1 MMP9 CAMK2A PIK3R1 FGF19 SPRY2 CBL PLCG1 RUNX2 STAT5B PDPK1 STAT1 FGFR4 FGFR3 CTNND1 SRC PIK3CA JUN CDH1 GAB1 FOS PTPN11 FRS2 CTTN KLB FGFR1 FGF1 RPS6KA1 NCAM1 PLAUR IL17RD GRB2 PLAU SSH1 SOS1 SDC2 SPP1 FGFR2 PAK4 MAPK1 SHC1-1 PTK2B ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events ACVR1 SMAD1 FKBP1A SMAD9 SMAD5 SMAD4 AMHR2 AMH BMPR2 TLX2 BMP7 COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity CDKN2A CDK6 CCND1 KDM1A KLK3;KLK2 TMPRSS2 CASP8 UBE2I CARM1 PIAS1 MED1 RANBP9 PTK2B HIP1 TGFB1I1 FHL2 UBE3A VAV3 RPS6KA3 CCND3 GSN ZMIZ1 PAWR NKX3-1 APPL1 AKT1 NCOA6 NCOA4 TGIF1-1 LATS2 CTDSP1 PIAS4 CTDSP2 MAK NCOA2 ZNF318 PIAS3 SNURF HNRNPA1-1 FKBP4 KDM3A TMF1 KDM4C-1 PRDX1 PATZ1 SVIL PA2G4 TCF4 AR CMTM2 NRIP1 SRF UBA3 PRKDC BRCA1 PELP1 XRCC6 XRCC5 CTNNB1 E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes AKT2 CTNND1 SRC PIK3CA ZYX VASP AKT1 RHOA CDH1 CTNNA1 JUP FYN PIK3R1 PLCG1 CTNNB1 CASR FMN1 PIP5K1A AJUBA EGFR RAC1 IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events TIMP1 JAK1 MYC AKT1 MITF PIK3R1 PIAS3 SOCS3 FOXO1-1 JAK2 PRKCD MAPK14 STAT1 HCK STAT3 CRP HSP90B1 TNFSF11 TYK2 LBP A2M BCL2L1 MCL1 IL6 FGG PTPRE PIK3CA CEBPB IRF1 JUNB JUN VAV1 GAB2 MAP2K6 GAB1 FOS PTPN11 MAPK11 IL6R PIAS1 LMO4 GRB2 IL6ST SOS1 CEBPD RAC1 MAP2K4 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway EPHA3 EFNA5 EPHA2 EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway ATR PPP2CB;PPP2CA CDK2 YWHAB PPP2R1A CLSPN BTRC BRCA2 CHEK1 FBXW11 ATRIP PLK1 YWHAZ CDC25C RFC5 RFC3 RFC4 RFC2 RPA1 CDC25A CCNA2-1 RPA2 SMARCAL1 HUS1 MCM7 CEP164 TIPIN RAD17 CDC6 RAD1 PPP2R2B TIMELESS RAD9A MCM2 MDM2-2 NBN TOPBP1 RAD51 FANCD2 DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin APC LRP6 CSNK1D GSK3B FZD5 CSNK1A1 CUL1 WNT3A SKP1 DVL1 BTRC AXIN1 AXIN2 DVL2 TPTEP2-CSNK1E;CSNK1E DVL3 CTNNB1 GSK3A IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway YWHAE AKT1 PTPN1 IGF1 BCAR1 PIK3R1 NCK2 RACK1 BAD PDPK1 PRKCD YWHAZ RPS6KB1 PRKCZ IRS1 PIK3CA PXN IRS2 GRB10 HRAS PTPN11 PRKD1 IGF1R PTK2 CRKL GRB2 SOS1 RAF1 CRK SHC1-1 CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin MAP2K2;MAP2K1 MAPK3 IL1B MAP2K7 MAP2K3 MAP2K6 CALM3;CALM1 TNF ANTXR2 CASP1 ANTXR1-1 NLRP1 PGR VCAM1 IL18 MAPK1 MAP2K4 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods RPE65 GRK1 RDH12 RGS9BP RDH5 GNB1 LRAT GNB5 RGS9 LOC118142757;GUCA1A SLC24A1 GNGT1 SAG CNGA1 RHO PDE6B PDE6A GNAT1 CNGB1 GUCY2D GUCA1C FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network FOXM1 MAP2K2;MAP2K1 CENPB BIRC5 CKS1B SKP2 CDK4 NEK2 SP1 GAS1 MYC CDKN2A H2BC1 XRCC1 CDK2 EP300 MMP2 CENPF CCNB1 CCND1 RB1 BRCA2 CHEK2 PLK1 CDC25B GSK3A CCNA2-1 ETV5 CDK1 NFATC3 FOS CENPA CCNB2 AURKB CREBBP HSPA1A;HSPA1B CCNE1 LAMA4 ESR1 ONECUT1 TGFA IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events GRK2 GNG2 PRKCG GNAI2 CXCR1 AKT1 PLCB3 GNB1 PLCB1 CXCL8 ARRB2 CBL PLD1 RAB5A GNA14 LYN PDPK1 GNA15 PIK3CG PIK3R6 FGR HCK DNM1 PLCB2 PRKCB PRKCE PRKCA ARRB1 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions SPON2 ICAM2 ICAM3 ICAM4 F11R THY1 FGB FGA F10 GP1BA PROC TGFBI KNG1 VCAM1 FGG C3-1 CCN1 ITGAM ITGB2 PLAT ITGAL ITGAX ICAM1 CD40LG JAM3 PLAUR ITGAD PLAU INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport STX4 YWHAE AKT1 GSK3B INSR YWHAB PRKCI YWHAQ SFN YWHAG YWHAH ASIP PPP1R3A GYS1 LNPEP TRIP10 VAMP2 YWHAZ RHOQ AKT2 PRKCZ SLC2A4 TBC1D4 CALM3;CALM1 STXBP4 PPP1CC INS;INS-IGF2 PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway MAP2K2;MAP2K1 PAG1 PIK3R1 AFDN RAP1B SPHK1 ABL1 NCK2 JAK2 STAT5A STAT1 S1PR1 STAT3 PIK3CB PIK3CA CYFIP2 NCKAP1 WASF2 MAP2K7 MAPK10 CTTN ABI1 RAPGEF1 ITGB3 MAPK8 MAPK1 ITGAV MAP2K4 RAC1 KSR1 MAPK3 RPS6KA3 PPP2CB;PPP2CA EIF2AK2 RHOA ARPC1B PAK1 BCAR1 ARHGDIA PPP2R1A BLK PTPRJ ACTR2 ARPC4 ARPC5 PTPN2 BAIAP2 ARPC2 LYN ARPC3 ACTR3-1 FGR HCK SRF PTEN SRC RAP1A GRB10 HRAS PPP2R2B NCK1 GAB1 PTPN11 PRKCA DOK1 RASA1 GRB2 SOS1 CRK SHC1-1 CSK YWHAE PTPN1 YWHAB YWHAQ SFN PLCG1 YWHAG YWHAH PRKCD BRAF YWHAZ USP6NL ELK1 SLA ACTN4 SLC9A3R2 SLC9A3R1 RAB4A DOCK4 MAPK9 MYOCD ARAP1 ACTA2 SIPA1 JUN NRAS FOS PRKCE JUND KRAS VAV2 MYC PLA2G4A WASL FYN YES1 CBL RAB5A STAT5B PIK3CG PIK3R6 EPS8 PIN1 LCK LRP1 ARHGAP35 DNM2 PDGFRB RAF1 PDGFB IQGAP1 ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway ACVR1 FKBP1A ACVRL1 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway NECTIN2 PIK3R1 F11R AFDN RAP1B SRC PIK3CA PTPRM CLDN1 PVR RAP1A PIP5K1C CDH1 NECTIN3 CTNNA1 NECTIN1 PTK2 PDGFRB RAPGEF1 ITGB3 CDC42 CTNNB1 TLN1 VAV2 CRK PDGFB FARP2 IQGAP1 ITGAV RAC1 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway MAP2K2;MAP2K1 PAG1 CSK TRAF6 PIK3R1 RELA MAP4K1 PDPK1 ELK1 DAPP1 BLNK NFKB1 PLCG2 NFKBIA IKBKB PIK3CA JUN IKBKG PPP3CB PPP3CC CARD11 NFATC1 FOS BCL2A1 BCL10 CALM3;CALM1 MALT1 BTK CD79B CAMK2G CD79A CD19 SH3BP5 CD72 IBTK PTPRC CD22 MAPK8 NFKBIB VAV2 ETS1 MAPK1 RAC1 MAPK3 POU2F2 MAP3K1 SYK CHUK AKT1 INPP5D LYN MAPK14 CSNK2A1;CSNK2A3 PPP3CA PTPN6 PTEN HRAS MAP3K7 DOK1 RASA1 GRB2 SOS1 RAF1 SHC1-1 REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity AKAP13 ARHGEF10 VAV3 FARP1 NGEF ARHGEF12 ARHGEF17 ARHGEF11 PLEKHG6 ARHGEF28 ARHGEF18 MYO9B TRIO NET1 RHOA DLC1 ARHGEF3 ARHGAP5 ARHGEF1 ARHGEF5 ARHGDIA ARHGDIB ECT2 CDKN1B ARHGAP9 ARAP1 ABR ARAP3 DEF6 VAV1 BCR ARHGEF2 ARHGAP35 ARHGEF25 ARHGEF15 ARHGDIG ARHGEF10L MCF2L VAV2 ARHGAP6 ARHGAP4 OPHN1 ARHGAP8;PRR5-ARHGAP8 MCF2 SRGAP1 EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin STXBP1 RAB3GAP2 STX1A VAMP2 CHRNA1 UNC13B RIMS1 SNAP25 SYT1 NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway SKP2 CCND1 NOTCH1 KDM1A MAML2 MAML1 RBPJ FURIN YY1 DNM1 RBBP8 SPEN ADAM12 NCOR2 IL4 PSENEN NUMB APH1A FBXW7 NCSTN EPS15 CDKN1A APH1B ITCH MYC EP300 CBL BTRC DNER ADAM10 NOTCH2 NOTCH3 ENO1 NOTCH4 DTX1 DLL1 DLL3 DLL4 MARK2 JAG2 NCOR1 JAG1 CNTN6 MYCBP-1 DLK1 MIB1 MFAP5 MFAP2 NEURL1 CNTN1 HDAC1 LNX1 CTBP1 PTCRA GATA3 CUL1 SKP1 RAB11A GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network MDK GPC2 IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 JAK1 ELF1 CCND3 SP1 MYC LTA CDK6 PIK3R1 IL2RG STAT5B STAT5A CCND2 PRF1 FASLG BCL2L1 CCNA2-1 PIK3CA GAB2 LCK IL2RB FOXP3 BCL2 PTPN11 IL2 IL4 IL2RA GRB2 SOS1 SHC1-1 JAK3 ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events MAP2K2;MAP2K1 MAPK3 AKT1 CHRNA1 PIK3R1 BAD JAK2 MTOR STAT3 MAPK9 PIK3CB SRC PRKACA-1 PIK3CA JUN NRAS DOCK7 HRAS PPP3CB ERBB3 ERBB2 CHRNE USP8 FOS NRG2 RNF41 PTPN11 NFATC4 MAPK10 NF2 KRAS CDC42 MAPK8 GRB2 SOS1 RAF1 MAPK1 SHC1-1 RAC1 NRG1 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events PPP2CB;PPP2CA GNG2 PRKCG GNAI2 VASP AKT1 PLCB3 GNB1 PLCB1 PPP2R1A CXCL8 ARRB2 CBL RAB5A PLD2 ELMO1 GNA14 LYN PDPK1 GNA15 PIK3CG PIK3R6 FGR HCK DNM1 PLCB2 DOCK2 PRKCB PRKCA CXCR2 RAB7A RAB11A ARRB1 FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks FOXA1 FOXA3 FOXA2 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events SDC3 SDC1 SDC2 SDC4 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions COL1A2 COL1A1 VEGFA SDC4 F11R COL4A1 THY1 FGB FGA LAMB1 COL4A4 VTN TGFBI SPHK1 COL4A3 COL4A6 THBS1 SDC1 COL4A5 FN1 TGFBR2 TNC FGG PVR CCN1 ITGA2B KDR HMGB1-1 PDGFRB ITGB3 IBSP EDIL3 PLAUR L1CAM PECAM1 PLAU CD47 SPP1 FBN1 PDGFB LAMA4 ITGAV LAMC1 THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway F2 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events MAP2K2;MAP2K1 CDK2 PIK3R1 CISH SOCS3 STAT5A STAT1 STAT3 MAPK9 PIK3CA JUN NRAS FOS PRKCB PRKCE IL2 MAPK11 KRAS IFNG IL2RA MAPK8 MAPK1 PTK2B JAK3 JAK1 MAPK3 MYC SYK DOK2 RHOA FYN MAPKAPK2 IL2RG SOCS1 STAT5B MAPK14 IRS1 IRS2 HRAS GAB2 LCK IL2RB BCL2 PTPN11 RASA1 GRB2 SOS1 RAF1 IKZF3 STAM2 SHC1-1 SOCS2 STAM GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway GPC2 GPC3 GPC1 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway NONO NR1D1 ATR NPAS2 ARNTL PER2 PER1 CRY2 CRY1 WDR5 CLOCK TIMELESS TPTEP2-CSNK1E;CSNK1E BHLHE40 CHEK1 IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events CD8B;CD8B2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CCR5 IL1R1 CCL3L1;CCL3L3;CCL3;CCL18 CD3E RELB CCL4L2;CCL4L1;CCL4 HLX RELA GADD45B GZMA IL18RAP NFKB2 STAT4 GADD45G IL12B IL12RB1 JAK2 STAT5A NOS2 IL12A STAT1 IL12RB2 STAT3 IL18 CD3G CD3D RIPK2 TYK2 NFKB1 FASLG TBX21 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CD4 IL1B HLA-DRA CD247 IL18R1 MAP2K6 FOS IL2 IL4 IFNG IL2RA ATF2 SPHK2 IL2RG SOCS1 STAT6 MAPK14 MTOR MAP2K3 LCK IL2RB RAB7A B2M GZMH;GZMB-1 EOMES CD8A BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions CCN1 MADCAM1 TGFBR1-1 VTN ITGB8 ITGB7 ITGB6 ITGA4 SDC1 EDIL3 PLAUR FN1 PLAU FBN1 VCAM1 ITGB5 ITGAV INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis COL1A2 COL1A1 COL3A1 COL2A1 IGF1 VEGFA COL5A1 F11R COL4A1 PIK3R1 COL4A4 ROCK1 COL7A1 CDKN1B COL6A2 COL6A1 COL5A2 COL4A3 PIK3C2A COL4A6 ADGRA2 SDC1 ANGPTL3 COL4A5 COL6A3 MFGE8 FN1 PI4KA PI4KB CASP8 PIK3CA ITGB3 ILK SPP1 MAPK1 PTK2B ITGAV RAC1 MAPK3 VAV3 AKT1 RHOA BCAR1 CBL VTN TGFBR2 RPS6KB1 IRS1 SRC PXN HSP90AA1 FGF2 PTPN11 IGF1R KDR PTK2 EDIL3 CSF1R TLN1 VCL CSF1 COL11A1 COL11A2 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III FHL2 TP53 EP300 BAX HDAC4 FOXO4 SIRT1 FOXO3 SIRT2 PPARGC1A SIRT3 XRCC6 FOXO1-1 KAT2B CREBBP ACSS2 CDKN1A TUBB2B;TUBB2A HOXA10 H1-4 ACSS1 MYOD1 MEF2D RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling MAPK3 RARA RARB PRKCG EP300 AKT1 NCOA1 NCOA2 NCOA3 HDAC3 MAPK14 KAT2B NRIP1 CCNH CDK7 RBP1 MNAT1 PRKACA-1 RXRB CDK1 RXRA HDAC1 NCOR2 RXRG PRKCA RARG MAPK8 CREBBP MAPK1 VDR HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha TP53 NAA10 CDKN2A CUL2 ARNT HIF3A RBX1 HSP90AA1 OS9 ELOC-1 COPS5 ELOB VHL HIF1AN EGLN1 EGLN3 EGLN2 RACK1 HIF1A FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network SP1 COL18A1 NKX3-1 EP300 DSCAM NCOA3 AP1B1 CDKN1B VTN TFF1 PRDM15 AR NRIP1 KLK3;KLK2 NDUFV3 ATP5PF XBP1 CEBPB JUN SERPINA1 POU2F1 CYP2C18-1 SOD1 C4BPB SFTPD BRCA1 GCG FOS NR2F2 PISD NFIA NFIB FOXA1 NFIC SCGB1A1 FOXA3 FOXA2 APOB CREBBP ESR1 SHH INS;INS-IGF2 NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway RHOA CAMK2A YES1 TAB2 CSNK1A1 TAB1 ROCK1 ARRB2 PPARG MAPK9 PRKCZ CTHRC1 MAP3K7 FZD2 FZD5 NFATC2 MAPK10 FZD7 DVL1 DVL2 FZD6 DVL3 WNT5A CHD7 FLNA SETDB1 CDC42 DAAM1 MAPK8 ROR2 NLK RAC1 PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling GNAO1 GNAZ GNG2 GNAI2 NOS3 MMP2 AKT1 MMP9 RHOA PLCB3 GNB1 IGF1 BCAR1 PLCB1 PIK3R1 GNA13 GNA14 GNA15 GNA11 GNAQ PLCB2 SRC PIK3CA NRAS HRAS ESR2 PELP1 MSN MAPK11 IGF1R KRAS ROCK2 HBEGF GNAL GRB2 STRN SOS1 GNAI3 SHC1-1 GNAI1 ESR1 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription APC CDKN2A ID2-1 YWHAE TCF7L2 YWHAB VCAN CCND1 YWHAQ CXCL8 SFN YWHAG YWHAH SNAI2 YWHAZ CAMK4 RUVBL2 TLE1 JUN XPO1 TBXT DVL3 INCENP TCF7L1 ZCCHC12 CHD8 CBY1 FGF4 MED12 SALL4 PITX2 TLE4 MYOG TLE2 MYC KRT1 CTNNBIP1 EP300 MMP2 TLE5 MMP9 DKK4 MDFIC MITF TBL1XR1 TNIK TCF7 ADCY7 NCOA2 CACNA1G IGF2BP1 HBP1 CDX4 BTRC CDX1 AXIN2 KCNIP4 KLF4 SMARCA4 BCL9 SP5 TRRAP NEUROG1 MYF5 TCF4 AR CCND2 HDAC2 TERT HDAC1 CDH1 CCN1 CTBP1 CUL1 SKP1 DKK1 CTNNB1 LEF1 EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway EPO PIK3R1 CBL PLCG1 SOCS3 INPP5D SH2B3 EPOR JAK2 LYN STAT5B TEC STAT5A MAPK14 STAT1 NFKB1 PTPN6 PLCG2 BCL2L1 IRS2 RAP1A HRAS GAB1 BCL2 PTPN11 BTK CRKL RAPGEF1 MAPK8 GRB2 SOS1 VAV2 SHC1-1 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway MAP3K1 TXN TRAF2 MAP3K3 TRAF6 CCM2 TAB2 TAB1 GADD45B GADD45G MAP3K6 MAPK14 MAP3K4 TAOK3 TAOK1 TAOK2 CAMK2B MAP3K10 MAP3K5 MAP3K7 MAP2K6 MAP2K3 CALM3;CALM1 MAPK11 GADD45A RAC1 ATM C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway PPP2CB;PPP2CA SKP2 MYC CDKN2A GSK3B HBP1 PAK2 RUVBL1 TRRAP KAT2A PML ACTL6A KAT5 RUVBL2 SUPT3H PIN1 SUPT7L MAX TAF9 AXIN1 TAF12 ZBTB17 TAF10 FBXW7 PPP2R5A S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway MAPK3 GNAO1 GNAZ GNAI2 RHOA VEGFA PLCG1 KDR ABCC1 PDGFRB SPHK1 PTGS2-2 S1PR1 PDGFB GNAI3 MAPK1 GNAI1 PLCB2 RAC1 GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network FLT1 APP FYN VEGFA BLK YES1 TGFBR1-1 LAMA1 TGFB1 TGFB3 LYN FGR HCK TGFBR2 SERPINC1 PLA2G2A-1 SLIT2 PRNP TDGF1 SRC LCK FGF2 SMAD2;SMAD3 FGFR1 GPC1 NRG1 ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins MAP2K2;MAP2K1 EDN1 COL1A2 GNAO1 GNAZ GNA12 MMP1 GNAI2 COL3A1 GNA14 JAK2 PRKCD GNA15 GNA11 GNAQ JUN FOS PRKCB PRKCE CDC42 MAPK8 GNAL MAPK1 PTK2B RAC1 MAPK3 PRKCG TRPC6 AKT1 PLA2G4A RHOA PLCB3 BCAR1 PLCB1 ADCY7 MAPK14 PLCB2 SLC9A1 EDNRA SRC CYSLTR1 CYSLTR2 EDNRB PRKCH HRAS EDN2 EDN3 ADCY9 ADCY4 ADCY3 ADCY2 PRKCA ADCY1 ADCY8 ADCY6 ADCY5 SLC9A3 RAF1 CRK GNAI3 PRKCQ GNAI1 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network KDR VEGFC VEGFD NRP1 NRP2 FLT1 FLT4 VEGFB PGF VEGFA NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte TRPC6 AKT1 WASL PRKCI FYN PIK3R1 ARRB2 PLCG1 NCK2 BAD MAPK9 PIK3CB PRKCZ PARD6A PIK3CA JUN NCK1 TJP1 MAPK10 MAPK8 KIRREL1 GRB2 CD2AP NPHS1 F2RL2 NPHS2 RAC1 MAP2K4 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events LPAR4 GNAO1 GNAZ GNA12 GNAI2 GSK3B PIK3R1 TRIP6 CXCL8 RELA PLCG1 GNA14 PRKCD GNA15 GNA11 GNAQ SLC9A3R2 NFKB1 PIK3CB NFKBIA CASP3 JUN FOS PRKCE TIAM1 HBEGF MAPT PTK2B RAC1 GNG2 MMP2 AKT1 MMP9 RHOA PLCB3 GNB1 ARHGEF1 BCAR1 ADCY7 PLD2 GNA13 LYN SRC PXN HRAS ADCY9 GAB1 ADCY4 ADCY3 ADCY2 PRKD1 ADCY1 ADCY8 ADCY6 PTK2 ADCY5 CRK ADRA1B GNAI3 LPAR1 GNAI1 LPAR2 EGFR LPAR3 BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions NPNT COL1A2 NID1 CSPG4 COL1A1 COL3A1 COL2A1 LAMB3 LAMA2 VEGFA COL5A1 COL4A1 LAMB2 LAMC2 FGB FGA COL4A4 LAMB1 COL7A1 COL6A2 COL6A1 LAMA1 COL5A2 TGFBI COL4A3 LAMA3 COL4A6 COL4A5 COL6A3 FN1 ITGA3 TNC F13A1 TGM2 ITGB1 ITGA4 ITGA2 ITGA1 PLAU ITGA10 SPP1 ITGA11 ITGA8 ITGA7 ITGA6 ITGAV ITGA5 LAMC1 ITGA9 COL18A1 IGSF8 VTN CD81 THBS2 THBS1 MDK CD14 JAM2 VCAM1 FGG PLAUR FBN1 LAMA5 LAMA4 COL11A1 COL11A2 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling ELANE FPR1 KLK4 VLDLR HGF FPR2 MMP9 PDGFD CTSG CTRC-2 BCAR1 MMP12 MMP13 FGB GPLD1 FGA VTN TGFB1 DOCK1 FN1 ITGA3 MMP3 FGG SRC ITGB1 ITGAM ITGB2 LRP1 PLG PDGFRB ITGB3 PLAUR PLAU CRK ITGB5 SERPINE1 EGFR ITGAV NCL-1 ITGA5 RAC1 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression CCL5 COL1A2 SP1 ID2-1 CCND1 GFI1 CLU CDKN1B FTH1 HMGCS2 TBP SLC11A1 DNMT3A TSC2 SFRP1 TMEFF2 CSDE1 ALDH9A1 GTF2H2C;GTF2H2C_2;GTF2H2 NDRG2 NDRG1 ZFP36L1 NFYB NFYC TMEM126A-1 S100A7A;S100A7 SFXN3 NFYA-1 TJP2 MXD4 ITGB1 DDIT3 ERBB2 LGALS1 ITGB4 DNTT CFLAR GADD45A IRF8 SPI1 CDKN1A ITGA6 MYC EP300 HDAC3 CREB1 RBL1 PTPA HDAC1 MAX BRCA1 FOXO3 BCL2 SMAD2;SMAD3 PDGFRB WNT5A ZBTB17 CDKN2B DKK1 CEBPA SMAD4 CEBPD ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network AREG EGF HSP90AA1 ERBB4 ERBB3 ERBB2 NRG2 EREG BTC NRG3 NRG4 HBEGF EGFR TGFA NRG1 SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II NR3C1 GRK2 HDAC10 GNG2 HDAC11 YWHAE YWHAB GNB1 MEF2C HDAC5 HDAC3 GATA2 HDAC9 HDAC6 GATA1 HDAC7 CAMK4 TUBB2B;TUBB2A BCL6 SRF RFXANK NCOR2 HSP90AA1 BCOR ANKRA2 RANBP2 HDAC4 XPO1 UBE2I SUMO1 RANGAP1 RAN ESR1 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling YWHAE CAMK2A TAB2 TAB1 NEDD4L PDPK1 ZFYVE9 DACT2 RNF111 TGFBR3 ZFYVE16 STRAP PPP2R2A;PPP2R2D AXIN1 PPP1R15A TGFBRAP1 FKBP1A OCLN-1 YAP1-1 SPTBN1 SMURF2 DAB2 BAMBI DYNLRB1 WWP1 EIF2A PPP2CB;PPP2CA ITCH TGFBR1-1 ARRB2 TGFB1 TGFB3 CAV1 DAXX XIAP TGFBR2 SMURF1 PPP1CA RPS6KB1 PML PARD6A MAP3K7 SMAD2;SMAD3 CCN2 GRB2 SOS1 CTNNB1 SMAD4 SHC1-1 SMAD7 ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions ITGB7 CDH1 ITGAE JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway MAP3K1 LCP2 JUN MAP3K7 PRKCB LAT GRAP2 MAP4K1 CRKL MAPK8 DBNL CRK MAP3K8 MAP2K4 ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes YWHAE GSK3B YWHAB YWHAQ CSNK1A1 SFN YWHAG YWHAH BAD PRKCD YWHAZ CAMK4 MAP3K8 MEF2D MAPK9 AKAP5 PRKCZ CABIN1 PRKACA-1 CASP3 CHP1 NFATC3 NFATC2 XPO1 NFATC1 PRKCB CALM3;CALM1 PRKCE RAN FKBP1A RCAN1 MAPK8 RCAN2 KPNB1 KPNA2 NUP214 FKBP8 NR4A1 MAPK3 MAP3K1 PRKCG EP300 BAX MAPK14 CSNK2A1;CSNK2A3 BCL2L1 PIM1 PRKCH BCL2 PRKCA CREBBP PRKCQ TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells LCP2 PAG1 CSK TRAF6 TRPV6 CD3E LAT GRAP2 PLCG1 MAP4K1 PDPK1 CD86 MAP3K8 CD80 CD3G CD3D RASGRP2 IKBKB HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 RASGRP1 CD4 CD28 ZAP70 HLA-DRA IKBKG NRAS CD247 CARD11 PRKCB BCL10 PRKCE MALT1 KRAS FLNA PTPRC CDC42 DBNL SLA2 RASSF5 STIM1 ORAI1 WAS STK39 SH3BP2 FYB1 CHUK AKT1 MAP3K14 FYN CBL INPP5D PTPN6 PTEN RAP1A VAV1 HRAS GAB2 NCK1 LCK PTPN11 PRKCA GRB2 SOS1 ITK SHC1-1 PRKCQ VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals MAPK3 FLT1 NOS3 AKT1 VEGFA PIK3R1 SHC2 CBL PLCG1 CAV1 PDPK1 HIF1A PRKACA-1 PIK3CA HSP90AA1 NCK1 PRKCB PTPN11 CALM3;CALM1 PRKCA NRP1 NRP2 VEGFB RASA1 PGF CD2AP MAPK1 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events EDN1 EDNRA EGF GRB2 SOS1 HRAS MTOR SHC1-1 EGFR HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins MAP2K2;MAP2K1 SMO SIN3B GNAO1 GNAZ GNG2 SIN3A CSNK1G3 IFT172 GLI1 GNAI2 CSNK1D GLI3 AKT1 GSK3B STK36 KIF3A GNB1 CSNK1G2 RAB23 CSNK1G1 SPOP MTSS1 CSNK1A1 IFT88 ARRB2 BTRC TPTEP2-CSNK1E;CSNK1E FBXW11 SAP30 PRKCD HDAC2 PRKACA-1 LGALS3 HDAC1 XPO1 RBBP4 SAP18 RBBP7 PIAS1 FOXA2 PTCH1 CREBBP GNAI3 GNAI1 GLI2 SHH INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway SGK1-1 EIF4EBP1 AKT1 PTPN1 INSR PRKCI PIK3R1 SORBS1 CBL INPP5D NCK2 SH2B2 CAV1 PDPK1 TRIP10 RHOQ RPS6KB1 PTPRA AKT2 PRKCZ IRS1 PARD6A PIK3CA GRB10 HRAS NCK1 EXOC7 FOXO3 PTPN11 GRB14-1 DOK1 RAPGEF1 RASA1 EXOC4 EXOC3 GRB2 SOS1 EXOC6 CRK F2RL2 EXOC5 EXOC2 SHC1-1 INS;INS-IGF2 EXOC1 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network PDGFRB PDGFRA PDGFD PDGFA PDGFB PDGFC EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling VAV3 EPHA2 SRC PIK3CA RHOA PAK1 BCAR1 PIK3R1 CBL ARHGAP35 TIAM1 ACP1 PTK2 GRB2 VAV2 EFNA1 INPPL1 SHC1-1 RAC1 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling MAP2K2;MAP2K1 EGF PIK3R1 STAT1 STAT3 MAPKAP1 PIK3CB MLST8 RICTOR PIK3CA CYFIP2 NCKAP1 WASF2 ABI1 CDC42 MAPK8 MAPK1 MAP2K4 RAC1 KSR1 MAPK3 RPS6KA3 PPP2CB;PPP2CA MAP3K1 ARPC1B PPP2R1A ACTR2 PLD1 SMAD1 PLD2 ARPC4 ARPC5 BAIAP2 ARPC2 ARPC3 ACTR3-1 SRF SLC9A1 SRC HRAS GAB1 PRKCA GRB2 SOS1 F2RL2 CAPN2 YWHAE YWHAB YWHAQ SFN YWHAG YWHAH EGR1 BAD PDPK1 PRKCD BRAF YWHAZ USP6NL ELK1 MAPK9 PRKCZ JUN DUSP1 NRAS PEBP1 FOS CALM3;CALM1 PPP2R2A;PPP2R2D KRAS RIN1 ATF2 VAV2 ATF1 RPS6KA4 RPS6KA5 AKT1 WASL MEF2C RAB5A ARF4-1 ZFP36 RALGDS MAP2K5 MYLPF PPP5C DIAPH3 DUSP6 MAPK7 MAP3K2 MTOR CREB1 BCL2L1 EPS8 CHN2 RPS6 RALA-1 RAF1 IQGAP1 EGFR LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development VLDLR YWHAE RHOA DYNLT1 MAP1B NUDC ABL1 LRP8 PLA2G7 RELN CSNK2A1;CSNK2A3 KATNA1 NDEL1 DYNC1H1 CLIP1 DAB1 DCX PAFAH1B3 CDK5R2 PAFAH1B2 CDK5R1 PAFAH1B1 CALM3;CALM1 LRPAP1 CDC42 PPP2R5D IQGAP1 CDK5 RAC1 SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL MAPK3 RHOC SRC CCNA2-1 CDK2 RHOA RABGGTB AGT ITGB1 RABGGTA BCAR1 PTP4A2 PTP4A3 PTP4A1-1 ATF5 ROCK1 EGR1 ITGA1 CDKN1A CCNE1 MAPK1 RAC1 EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling PTPN13 FYN BLK PIK3R1 YES1 EFNB2 NCK2 EFNB1 LYN EPHB2 EPHB1 EPHB4 FGR HCK DNM1 SRC PIK3CA MAP3K7 LCK ITGA2B RGS3 TIAM1 ITGB3 MAPK8 RAC1 MAP2K4 VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium MAPK3 COL1A2 AKT1 COL1A1 PIK3R1 FN1 MAPK14 CREB1 VEGFC VEGFD PIK3CA ITGB1 MAPK11 FLT4 ITGA4 RPS6KA1 ITGA2 ITGA1 GRB2 SOS1 CRK MAPK1 SHC1-1 ITGA5 MAP2K4 ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events EPHA2 HGF EGF ARRB2 GNA14 GNA15 GNA11 GNAQ MET CYTH3 CYTH2 SRC PXN ADRB2 ADAP1 NCK1 ITGA2B TSHR KIF13B FBXO8 LHCGR IQSEC1 ACAP1 ARAP2 ITGB3 IPCEF1 AGTR1 GULP1 ACAP2 GIT1 EFNA1 ARF6 EGFR ARRB1 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network AEN CCNE2 NDUFS2 HAGH NTRK1 SP1 PFDN5 PLPP1 FBXO45 CDK2 AFP GRAMD4 HSF1 CLCA2 BUB3 CDK6 BAK1 BCL2L11 DEDD GDF15 RB1 NSG1 ADA SFN TP53I3 RELA WT1 TP73 DCP1B BRCA2 NEDD4L ABL1 RACK1 CHEK1 GATA1 HEY2 KAT5 CCNA2-1 RCHY1 SERPINA1 WWOX MDM2-2 MAPK11 FAS YAP1-1 CDKN1A SERPINE1 JAK1 IL4R ITCH MYC TP63 PLK3 FASN EP300 BAX CCNB1 SIRT1 CASP2 BUB1 PRKACB-1 PLK1 MAPK14 JAG2 PML PIN1 CDK1 FOXO3 BIN1 IL1RAP BBC3 TUBA1A PEA15 RAD51 FLOT2 RNF43 S100A2 UBE4B CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events MAP2K2;MAP2K1 MAPK3 GNAO1 GNAZ GNG2 GNAI2 AKT1 CXCL9 GNB1 CCL11 PIK3R1 CXCL13 CXCR3 PF4;PF4V1-1 PDPK1 CXCL10 CXCL11 MAPK14 MTOR DNM1 MAPKAP1 PIK3CB MLST8 RICTOR SRC PIK3CA NRAS HRAS MAP2K6 MAP2K3 MAPK11 KRAS RAF1 GNAI3 MAPK1 GNAI1 ARRB1 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events PIK3R1 CISH YWHAG CSF2RB INPP5D PRKACB-1 JAK2 STAT5B STAT5A SRP9 YWHAZ CNKSR1 IL3RA ID1 BCL2L1 PRKACA-1 PIK3CA CEBPB PIM1 HDAC1 GAB2 PTPN11 IL3 OSM GRB2 SHC1-1 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling GNA12 GNAI2 NOS3 PRKG1 EGF ROCK1 GNA14 PRKCD GNA15 GNA11 GNAQ PTGDR PTGIR DNM1 TBXA2R SLC9A3R1 TGM2 PRKCZ PRKACA-1 PRKCB PRKCE MAPK11 SELE RAC1 GRK2 GRK3 GNG2 SYK PRKCG AKT1 RHOA GNB1 ARHGEF1 FYN BLK YES1 ARRB2 GNA13 LYN PIK3CG MAPK14 FGR PIK3R6 HCK VCAM1 PLCB2 ARR3 SRC PRKCH LCK GNB5 PRKCA ICAM1 RAB11A PRKCQ EGFR A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling IL1A MST1 YWHAE AKT1 EGF YWHAB LAMB3 LAMA2 PIK3R1 CASP7 LAMB2 LAMC2 YWHAQ LAMB1 SFN YWHAG LAMA1 YWHAH LAMA3 YWHAZ MET RPS6KB1 COL17A1 PMP22 CD9 PIK3CA RXRB RXRA CDH1 RXRG HRAS ITGB1 ERBB3 ERBB2 ITGB4 PRKCA MST1R GRB2 SHC1-1 LAMA5 LAMA4 ITGA6 EGFR LAMC1 RAC1 MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway MAP2K2;MAP2K1 SGK1-1 CDK2 YWHAE YWHAB YWHAQ SFN YWHAG YWHAH TSC2 PDPK1 YWHAZ BRAF YY1 MAPKAP1 PRR5 IKBKB RB1CC1 MLST8 TSC1 RICTOR ATG13 RRAGA RRAGC RRAGB RRAGD NRAS DDIT4 ULK2 ULK1 RRN3 POLDIP3 PPARGC1A EIF4B BNIP3 EEF2 RHEB PDCD4 RPTOR KRAS DEPTOR AKT1S1 RPS6KA1 EEF2K SREBF1 CYCS-1 MAPK1 MAPK3 EIF4EBP1 EIF4E AKT1 PLD1 BTRC PLD2 EIF4A1 FBXW11 MTOR RPS6KB1 PML CLIP1 IRS1 HRAS PRKCA RAF1 CCNE1 ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway BTRC NFKB1 NFKB2 CHUK MAP3K14 RELB DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors SP1 AFP VCAN BAK1 GDF15 RB1 TP53I3 TP73 MAP4K4 CASP10 DDIT4 BID MDM2-2 FAS STEAP3 CCNK PRDM1 PYCARD SESN1 FDXR BNIP3L TAP1 SPP1 PRKAB1 HIC1 MSH2 CTSD TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A DDX5 PCBP4 TP53BP2 SCN3B BCL2L14 TP63 SH2D1A PLK3 TADA2B COL18A1 RGCC MMP2 CD82 JMY BCL2L2 BTG2 BAX CCNB1 PPP1R13B CX3CL1 AIFM2 DGCR8 ZNF385A GPX1 PRMT1 DDB2 RNF144B SMARCA4 RRM2B CAV1 IRF5 TYRP1 TRRAP HTT RPS27L PPM1J NLRC4 TP53INP1 E2F2 DROSHA PMS2 TIGAR PML ARID3A MLH1 CEBPZ MCL1 PTEN POU4F1 POU4F2 EDN2 TAF9 PCNA PMAIP1 E2F3 HSPA1A;HSPA1B TGFA TP53 APC HGF SFN TSC2 SNAI2 MET NDRG1 NFYB NFYC NFYA-1 RCHY1 DUSP5 JUN DUSP1 SERPINB5 BCL2A1 CARM1 GADD45A PERP BDKRB2 IGFBP3 CDKN1A SERPINE1 EPHA2 EP300 PIDD1 CASP1 CSE1L APAF1 KAT2A TFDP1 BCL6 COP1 ATF3 BCL2L1 CASP6 CCNG1 HDAC2 E2F1 BCL2 FOXA1 LIF DKK1 CREBBP BBC3 VDR S100A2 EGFR LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events LPAR4 RPS6KA5 PRKACA-1 ADCY9 ADCY4 ADCY7 ADCY3 ADCY2 PRKCE ADCY1 ADCY8 ADCY6 ADCY5 GNAL CREB1 POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly CDH2 SNX1 GNA12 NTRK2 MMP7 PTPN1 EGF BDNF FYN HGS RAB5A ABL1 ADAM10 GNA13 MET PTPN6 RET MMP3 ROBO1 CTNND1 SLIT1 SRC DSP CASP3 IGF2 CABLES1 ZBTB33 CDH1 MEP1B CTNNA1 HRAS CBLL1 JUP GFRA1 TIAM1 IGF1R DNM2 RAB7A NME1 GDNF CDC42 RIN2 CREBBP CTNNB1 IQGAP1 ARF6 EGFR RAC1 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling TP53 BIRC5 TACC1 ARHGEF7 AURKA AKT1 GSK3B PAK1 FZR1 CDC25B AJUBA NDEL1 CKAP5 TPX2 NFKBIA PRKACA-1 TACC3 OAZ1 DLGAP5 TDRD7 BRCA1 CPEB1 AURKAIP1 MDM2-2 CENPA GADD45A RAN RASA1 AURKB GIT1 PPP2R5D CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling MAP3K1 MYC TRAF1 TRAF2 AKT1 TRAF6 MAP3K14 PIK3R1 RELA STAT5A PIK3CG MAPK14 PIK3R6 MAPK9 NFKB1 PIK3CB NFKBIA BCL2L1 PIK3CA JUN MAPK10 CD40 MAPK11 TNFAIP3 IL4 C4BPA FCAMR TRAF3 BIRC2 TDP2 CD40LG BIRC3 MAPK8 CBLB JAK3 MAP2K4 VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network DDX54 SMARCA4 C3-1 SMARCB1 NR0B2 ESR2 SMARCE1 NCOA1 UBA3 NR0B1 NCOA2 NCOA3 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases AURKA AURKC AURKB LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events STK11IP TP53 STRADA STRADB ETV4 MYC STK26 SIK3 SIK2 YWHAE GSK3B YWHAB YWHAQ SFN YWHAG YWHAH TSC2 YWHAZ MTOR CREB1 MARK2 MLST8 TSC1 PRKACA-1 CDC37 HSP90AA1 EZR RPTOR AKT1S1 BRSK1 BRSK2 CRTC2 SMARCD3 CAB39 SMAD4 PSEN2 STK11 MAPT MAP2 CTSD ESR1 SIK1;SIK1B MARK4 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway EFNB2 EFNB1 EPHB2 EPHB1 EPHB4 EPHB3 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway MAP2K2;MAP2K1 MAPK3 NTF3 RPS6KA5 RUSC1 MAPKAPK2 MEF2C RAP1B EGR1 MAP2K5 PRKCD RIT1 TRPV1 MAPK14 RIT2 MAPK7 BRAF EHD4 ELK1 MAP3K2 CREB1 SRF RAP1A CDK5R1 NRAS HRAS MAP2K6 MAP2K3 FOS KRAS RPS6KA1 RAF1 MAPK1 CDK5 TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway MAP3K1 TRAF1 TXN CHUK TRAF2 TNFRSF1A NRK MAP3K3 MADD MAP4K5 RFFL PRKCI TNIK NSMAF MAP4K3 MAP4K2 TAB2 TNFRSF1B TAB1 SQSTM1 TNF CYLD RELA CAV1 RACK1 STAT1 MAP4K4 SMPD2 NFKB1 PRKCZ IKBKB CASP8 MAP3K5 SMPD1 RIPK1 FADD IKBKG MAP3K7 MAP2K7 MAP2K3 TNFAIP3 ADAM17 BIRC2 TRADD BIRC3 BAG4 FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks NR3C1 SP1 HNF4A AFP AKT1 ACADVL ALAS1 G6PC1 TAT SLC2A2 HMGCS1-1 TTR TFRC UCP2 NKX2-1 ACADM HADH PCK1 IGFBP1 CPT1A CREB1 KCNJ11 PKLR ABCC8 FOXF1 PDX1 APOA1 DLK1 HNF1A CPT1C CPT1B CEBPB GCK BDH1 ALB ALDOB F2 FOXA1 NF1 FOXA3 FOXA2 CEBPA CEBPD INS;INS-IGF2 CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events APC ARHGEF7 ARHGEF6 GSK3B PIK3R1 BRAF RASGRF1 MAPK9 PRKCZ PIK3CA JUN PAX6 MAP2K7 HES5 MAP2K6 SEPTIN2 TNK2 CDC42BPA ENAH PRKCE TIAM1 DLG1 CDC42 MAPK8 ATF2 VAV2 PAK4 MAPK1 RAC1 MAP2K4 MAPK3 MAP3K1 ARPC1B WASL PAK1 BCAR1 ARHGDIA ACTR2 YES1 PLD1 CBL IQGAP3 PAK2 ARPC4 ARPC5 BAIAP2 ARPC2 DIAPH3 ARPC3 MAPK14 ACTR3-1 MTOR MAP3K11 RPS6KB1 EPS8 SRC PARD6A CFL1 CDH1 HRAS CTNNA1 MAP2K3 EXOC7 LIMK2 LIMK1 MYL2 RAF1 CTNNB1 F2RL2 IQGAP1 CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events PAG1 GNAO1 GNAZ GNAI2 CSK CXCR4 RALB PIK3R1 CD3E RAP1B RACK1 BAD JAK2 PDPK1 STAT5A STAT1 STAT2 STAT3 DNM1 CD3G MAPKAP1 CD3D PIK3CB MLST8 PRKCZ HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 RHOC RICTOR CD4 RHOB PIK3CA HLA-DRA CD247 RGS1 VPS4B VPS4A GRK6 UBQLN1 PTPRC CDC42 SSH1 PTK2B RAC1 GRK2 GNG2 ITCH AKT1 MMP9 RHOA PLCB3 PAK1 GNB1 BCAR1 PLCB1 FYN BLK YES1 ARRB2 HGS CXCL12 INPP5D FOXO1-1 GNA13 LYN STAT5B PIK3CG FGR PIK3R6 HCK MTOR PLCB2 ARR3 PTPN6 SRC CFL1 PXN VAV1 LCK LIMK1 PTPN11 PTK2 CRK GNAI3 GNAI1 P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases SRF YWHAE YWHAB MAPKAPK3 YWHAQ MAPKAPK2 MAPK11 SFN YWHAG YWHAH ETV1 LSP1 TSC2 MAPK14 YWHAZ RAF1 CREB1 TH CDC25B HSPB1 PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling WNT1 MAPK3 APC PPARD MYC TLE5 GSK3B CCND1 CSNK1A1 TAB1 BTRC NOTCH1 ADAM10 FBXW11 RBPJ DTX1 DLL1 CSNK2A1;CSNK2A3 LRP6 HNF1A WIF1 TLE1 HDAC1 JUN FZD1 CTBP1 MAP3K7 FOS DVL1 AXIN1 PSENEN PSEN1 NKD1 NEDD4 DKK2 APH1A KREMEN2 CREBBP DKK1 CTNNB1 NCSTN APH1B MAPK1 PPP2R5D NLK VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms AEN SP1 CDKN2A CLCA2 YWHAQ GDF15 ADA TP53I3 ABL1 PRKCD MFGE8 ITGA3 IKBKB SERPINB5 ITGB4 MDM2-2 GADD45A FAS PERP OGG1 NOC2L FDXR DST DICER1 CDKN1A IGFBP3 TRAF4 SPATA18 EVPL WWP1 SHH NQO1 TFAP2C SSRP1 DHRS3 ITCH TP63 CHUK EP300 BAX HBP1 BTRC EGR2 PLK1 JAG1 PML CABLES1 PMAIP1 BBC3 SMARCD3 FLOT2 VDR S100A2 IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway MAP2K2;MAP2K1 JAK1 MAPK3 MAP3K1 PTGES2 IRF9 DAPK1-1 EP300 AKT1 CAMK2A PIAS4 PIK3R1 CAMK2D CBL CASP1 SOCS1 RAP1B PTPN2 JAK2 PRKCD STAT1 MTOR MAP3K11 STAT3 CAMK2B PIK3CA CEBPB IRF1 IL1B RAP1A PTPN11 CALM3;CALM1 CAMK2G CRKL PIAS1 RAPGEF1 IFNGR1 IFNG CREBBP MAPK1 SMAD7 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway CD4 KDELR1 GOSR2 USO1 ASAP1 GBF1 CLTB AP2A1 ARFGAP1 GGA3 ARFIP2 AP2M1 PLD2 ARF1 COPA PIP5K1A CLTA CYTH2 RAC1 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events IL1A UBE2N CHUK IRAK4 MAP3K3 TRAF6 PRKCI IL1R1 PIK3R1 TAB2 IRAK1 TAB1 SQSTM1 IL1RN ERC1 RELA CASP1 TICAM2 IL1R2 IRAK3 MYD88 TOLLIP UBE2V1 NFKB1 PRKCZ IKBKB PIK3CA IL1B JUN IKBKG MAP3K7 MAP2K6 IL1RAP MAPK8 GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network TP53 IL5 SGK1-1 CSN2-1 MMP1 AFP GSK3B CXCL8 SFN RELA YWHAH TBP EGR1 STAT5A STAT1 SMARCC1 CSF2 MAPK9 NFKB1 TBX21 IL13 IL6 PRKACA-1 IRF1 JUN POU2F1 NFATC1 FOS MAPK10 MDM2-2 IL2 MAPK11 IL4 SELE IFNG KRT16;KRT14 MAPK8 POMC SPI1 CDKN1A MAPK1 CDK5 NR4A1 NR3C1 KRT5 MAPK3 EP300 AKT1 BAX NCOA1 NCOA2 FKBP4 SMARCA4 VIPR1 SUMO2 PRKACB-1 STAT5B PPP5C KMT5B POU1F1 MAPK14 SMARCC2 FKBP5 CREB1 SMARCD1 TSG101 NR1I3 CGA PCK2 PBX1 KRT17 FGG HDAC2 HDAC1 CDK5R1 HSP90AA1 GATA3 ICAM1 CREBBP PRL INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 ARHGEF7 EGF PIK3R1 SPRY2 CBL HGS ITSN1 RAB5A UBE2D1 TSG101 DNM1 SYNJ1 PIK3CB UBE2D3;UBE2D2 EPN1 SRC PIK3CA CHMP3 AMPH STAMBP NRAS HRAS SH3GL2 LRIG1 USP8 UBE2D3-1 PTK2 SH3KBP1 KRAS CDC42 GRB2 SOS1 RAF1 EPS15 SHC1-1 CBLB EGFR E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network CCNE2 SP1 CDKN2A XRCC1 CDK2 SMARCA2 RBL2 RB1 CDKN1B TP73 YY1 RBBP8 CCNA2-1 CBX5 PLAU CDKN1A HIC1 SERPINE1 CCND3 MYC WASF1-1 EP300 PRMT5 CASP7 SIRT1 HBP1 TFE3 APAF1 TRRAP KAT2B KAT2A E2F2 RBL1 TFDP1 TK1 TRIM28 E2F4-1 MCL1 CDC25A CDK1 UXT HDAC1 E2F1 MYBL2 DHFR2;DHFR CDC6 TFDP2 MCM3 SULT2A1-4 BRCA1 RRM2-1 CES3 RBBP4 CES2 TOPBP1 CES1 TYMS CES5A ORC1 E2F5 E2F6 E2F3 E2F7 RANBP1 RRM1 CDKN2C CEBPA CREBBP POLA1 RYBP CCNE1 ATM CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway NFKB1 NFKBIA IKBKB CHUK TNFRSF1A IKBKG TRAF6 XPO1 BCL10 TNF UBE2D3-1 CYLD PRKCA MALT1 ERC1 TNFAIP3 RELA BTRC RAN BIRC2 NOD2 RIPK2 ATM EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling EFNA5 EPHA5 FYN TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells CD8B;CD8B2 LCP2 PAG1 CSK HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E TRAF6 TRPV6 CD3E LAT GRAP2 PLCG1 PDPK1 CD86 MAP3K8 CD80 PRF1 CD3G CD3D RASGRP2 IKBKB RASGRP1 CD28 ZAP70 IKBKG NRAS CD247 CARD11 PRKCB BCL10 PRKCE MALT1 KRAS PTPRC RASSF5 STIM1 ORAI1 CHUK AKT1 MAP3K14 FYN CBL PTPN6 RAP1A VAV1 HRAS LCK PRKCA B2M GRB2 SOS1 CD8A SHC1-1 PRKCQ REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase DKC1 POT1 TERF2 TERF2IP PIF1 SP1 PTGES3-1 SP3 TNKS WRN YWHAE ACD EGF ZNFX1 HNRNPC TERF1-1 CCND1 BLM CDKN1B WT1 ABL1 NFKB1 HUS1 IRF1 JUN RAD1 RAD9A FOS NR2F2 IL2 IFNG MAPK1 NCL-1 MAPK3 UBE3A SIN3B SIN3A MYC SMG5 AKT1 TGFB1 SAP30 MTOR RPS6KB1 MXD1 HDAC2 TERT HDAC1 E2F1 HSP90AA1 MAX MRE11 RBBP4 NBN SMAD2;SMAD3 SAP18 RBBP7 XRCC6 XRCC5 IFNAR2 RAD50 PINX1 SMG6 ESR1 PARP2 EGFR TINF2 ATM REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein SKP2 ELF1 CDK4 CBX4 CDKN2A CDK2 CDK6 SUV39H1 AATF CCND1 BRD2 RB1 PAX3 RBP2 CDKN1B DNMT1 CKM TBP PPP2R3B ATF7;ATF7-NPFF ABL1 TAF1 MET CSF2 MAPK9 CCNA2-1 JUN SFTPD TGFB2 MDM2-2 MAPK11 ATF2 SPI1 CDKN1A PPP2CB;PPP2CA CCND3 EP300 MITF SIRT1 MEF2C PPARG HDAC3 SMARCA4 RUNX2 MAPK14 CCND2 E2F2 UBTF TFDP1 MYOD1 E2F4-1 CEBPB HDAC1 E2F1 CTBP1 RBBP4 GSC SMARCB1 E2F3 RAF1 CEBPA CREBBP CEBPD CCNE1 REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling MAPK3 MAP3K1 CTDSP1 PIAS4 CTDSP2 UBE2I CALM3;CALM1 SMAD2;SMAD3 TGFBRAP1 CTDSPL NUP153 PPM1A KPNB1 SMAD4 KPNA2 NUP214 MAPK1 HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network EDN1 SP1 ID2-1 CITED2 EPO SLC2A1 CXCR4 PGK1 VEGFA COPS5 LEP EGLN1 EGLN3 BHLHE40 BHLHE41 NOS2 RORA ABCG2 ADM IGFBP1 HIF1A HK2 FURIN HK1 NDRG1 CA9 TF PGM1 PKM PLIN2 ALDOA PFKFB3 ABCB1 FECH NT5E GCK ARNT CP JUN PFKL ITGB2 FOS BNIP3 NPM1-2 ETS1 SERPINE1 HNF4A EP300 AKT1 NCOA1 NCOA2 CXCL12 TFF3-1 GATA2 TFRC ENO1 HDAC7 CREB1 ENG MCL1 TERT SMAD2;SMAD3 LDHA HMOX1 CREBBP SMAD4 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway VLDLR AKT1 GSK3B FYN PIK3R1 CBL MAP1B NCK2 ITGA3 MAP3K11 LRP8 RELN DAB1 PIK3CA RAP1A CDK5R1 GRIN2A PAFAH1B1 MAPK8IP1 ITGB1 MAP2K7 ARHGEF2 GRIN2B CRKL RAPGEF1 LRPAP1 MAPK8 MAPT CDK5 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway MAPK3 PIK3CB MAP3K1 IKBKB CASP8 PIK3CA CASP10 CHUK TRAF2 SMPD1 RIPK1 FADD IKBKG TNFSF10 DAP3 PIK3R1 CFLAR TRADD MAPK8 MAPK1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A MAP2K4 RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling MAPK9 GNG2 MAPK8 GNAL MAPK14 GNB1 CRH MAPK11 SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP JAK1 ATR EIF2AK2 HGF PTPN1 EGF INSR VEGFA PIK3R1 STAT6 PTPN2 STAT5B STAT5A STAT1 STAT3 MET RAB4A PIK3CB SRC PIK3CA ITGB1 GAB1 LMAN1 KDR PDGFRB PIAS1 ITGA1 CSF1R GRB2 CREBBP SOS1 KPNB1 KPNA2 PDGFB CSF1 SHC1-1 EGFR JAK3 EIF2A INS;INS-IGF2 BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling GSK3B CTDSP1 CTDSP2 TAB2 BMPR2 TAB1 SMAD1 CTDSPL SMAD9 PPM1A SMAD5 BMP4 XIAP SMURF1 PPP1CA MAP3K7 CHRD ZFYVE16 CHRDL1 HJV PPP1R15A SOSTDC1 CER1 AHSG FST SMURF2 NOG RGMB SMAD6 BAMBI BMP6 RGMA SMAD4 GREM1 NUP214 BMP2 MAPK1 BMPR1A BMP7 SMAD7 SKI PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events GNG2 RHOA GNB1 F2 ROCK1 ROCK2 GNA13 GNA14 MYL2 GNA15 GNA11 GNAQ F2RL2 F2RL3 PLCB2 FSH%NETPATH%FSH FSH MAP2K2;MAP2K1 GRK4 AKT2 FSHB FSHR GRK6 CGA APPL1 HEDGEHOG%NETPATH%HEDGEHOG Hedgehog ARRB2 GLI1 GLI2 MED12 PRKACA-1 CCNB1 GRK2 STK36 BOC SAP18 MED1 PTCH1 PTCH2 DYRK1A KIF7 MED6 KIF27 MED23 CDK8 CTNNB1 GAS1 YWHAE DHH HHIP IHH ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR AndrogenReceptor AR CREB1 HDAC1 HSPB1 AKT1 PIK3R1 PTK2 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_beta_Receptor HNF4A NCOA1 MAP4K1 PDPK1 FOXO1-1 FOS PJA1 TGFBR2 NME1 TGFBR3 RBL2 PPM1A KAT2B ZEB2 ZEB1 TFDP1 TFDP2 PIK3CA CRK CD44 ENG PPP1R15A FZR1 PARD6A STAMBPL1 YAP1-1 CTNNA1 SIK1;SIK1B MAPK1 CTNNA2 SAMD3 MAPK3 NFYB NFYC UBE2D3;UBE2D2 AP2B1 PML SKI FKBP1A EIF3I FOSB BCAR1 TRIM33 ARRB2 AR HDAC1 AKT1 PIK3R1 PTK2 RB1 ATF2 SPARC ZFYVE9 UBE2D1 ETS1 STK11 HOXA9 CDC23 CCND1 FNTA MYC SNIP1 SOX9 BTRC JUNB VPS39 SKP1 PDK1 NUP214 MAP2K3 MEF2A DAXX MEF2C ANAPC7 RUNX3 CDC25A RUNX2 RUNX1 RBX1 EID2 ZFYVE16 PRKAR1B CCNE1 EWSR1 ANAPC4 ANAPC5 TP53 PPP2R2A;PPP2R2D ANAPC1 ATF3 KPNB1 ANAPC2 E2F4-1 SDC2 PXN CUL1 PIK3R2 FOXO4 FOXO3 ANAPC10 SNX4 CCNB2 SNX1 SNX2 PRKAR2A SPTBN1 SNX6 MAP2K6 TRAP1 WWTR1 HSPA8 TGFB2 JUN SMAD4 JUND TGFB1 UBE2I SMURF1 TGFB3 VDR STK11IP CAV1 IRF2BP1 NUP153 SMAD6 ESR1 DAB2 SNW1 CDK6 COPS5 SP1 CDK4 CDC16 NFYA-1 DYNLRB2 DYNLRB1 TAB1 DCP1A TP73 GSK3B CDKN1A CITED1 BRCA1 CTCF UBE2D3-1 ING2 XPO1 XPO4 SUMO1 TCR%NETPATH%TCR TCR SHC1-1 MAP2K2;MAP2K1 DYRK1A CTNNB1 CREB1 AKT1 PIK3R1 PTK2 ATF2 PXN PIK3R2 GSK3B CRK MAPK1 MAPK3 ITSN2 CYFIP1 TFRC WIPF1 CBLB ENO2 CRKL GOLGA5 UBASH3B DPYSL2 TRIM25 HOMER3 PRKCD CD2AP PARD3 PRKD2 PRKD1 EPHA3 SKAP1 TXK PTTG1IP BCL10 LY9 LDHB LDHA INPP5D PLCG2 SLAMF6 PLCG1 ICOS PAG1 LYN VASP EGR1 CREBBP FYB1 NFATC2 LNPEP NFATC1 CGN EPRS1 CD28 UNC119 GRB2 GRAP CALM1 ADA ITK MTMR10 CLTC GDI2 CD3G PTPRH SHB CD3E CD3D IKBKB PPP3CB TUBA1A CTLA4 JAK3 VAV3 DUSP3 DBNL ANXA2 SYK RIPK2 FCRL3 NFAM1 PGAM1 GAB2 ZDHHC17 VAV1 VAV2 ENAH BDH1 RAPGEF1 ARHGEF2 HNRNPH3 ARHGEF7 ARHGEF6 AHCY WAS NEDD9 RELA PAK1 FLNB CCT8 MPZL1 DDX3X-1 GIT2 STAT1 ERBIN ELP3 DEF6 ACTR10 CD86 CD84 CD82 CD80 DGKA SLA ARHGAP35 SIT1 GRAP2 ARHGDIB MAP3K8 G6PD KIRREL1 ANXA11 SKAP2-2 DYRK1B PRPF4B LAX1 TUBA4A DOK1 ACLY DOK2 HGS ELMO1 ADAM9 PKP4 RAF1 STAM2 CARD11 KHDRBS1 TSG101 STK39 ITPR1 RASGRP2 STK4 RASGRP1 SDCBP RAP1A CASKIN2 ABL1 LPXN BMF ACBD6 NFKB1 NFKBIA DIAPH1 NCL-1 FER PTPRC PTPRA TUBB4A;TUBB;TUBB8B;TUBB8 OGN CDK1 PI4KA LAT NFKBIB HSP90AB1 DDX49 WDR1 PTPN22 CABIN1 PIK3C2B PSTPIP1 YWHAQ SNRNP70 ZNF404 ACP1 PGM1 NCK1 CHUK SH2D3C MSL2 YWHAZ DNM2 ACTA1 ZAP70 PKM LCK RASA1 PECAM1 C9orf78 LCP2 EVL DOCK2 SOS1 SOS2 R3HCC1L CEBPB SRC ATP1A3 ATP1A1 CBL HDAC7 DNAJB1 MUC1 MAPK8 MAPK7 SH3BP2 PTK2B SH2B3 TRAT1 TXNRD1 PTPN11 PTPN12 MAPK14 CD2 MAPK11 CD4 EIF3M TEC RPS6KB1 CD5 CD7 PTPN6 PIK3AP1 RAN PTPN3 LEPTIN%NETPATH%LEPTIN Leptin SHC1-1 CRP NCOA1 PRKAA1 GSK3A PRKAA2 ITGB5 PLCG2 IRS1 STAT1 IRS4 PLCG1 SLC2A4 ACACB EGFR IGF1R RPS6KA2 CFL2 ERBB2 EIF4EBP1 FYN CHUK EIF4E SOCS7 JAK1 SH2B1 NOS3 PRKCE GRB2 RPS6 LIMK1 AKT1 CDK5 GNAQ PTK2 LEP MAPK1 PDE3A SRC IKBKB JAK3 KHDRBS1 ESR1 MAPK8 GSK3B RUNX2 NFKBIA RPS6KB1 KITRECEPTOR%NETPATH%KITRECEPTOR KitReceptor STAT1 EIF4EBP1 FYN PIK3CA CRK RPS6 AKT1 PIK3R1 MAPK1 PTPRU ATF2 SH3KBP1 SPRED2 GYS1 SPRED1 RPS6KA1 EP300 JAK2 HRAS RAF1 PRKCB MATK PRKCA MITF FGR HCK KIT TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A WIPF1 EZR CBLB GRB7 CSF2RB CRKL SOCS1 ABL1 SOCS6 SOCS4 SOCS5 STAT5A STAT5B YES1 RDX MSN MTOR EPOR MAPK12 KITLG FES CDK2 IL7R MAD2L1 INPP5D GRAP RASA1 JUN CLTC SOS1 SRC JAK3 MAPK8 PTPN11 MAPK14 GSK3B TEC RPS6KB1 WAS RELA BCR%NETPATH%BCR BCR SHC1-1 MAP4K1 GSK3A PDPK1 FOS EIF4EBP1 FYN CRK RPS6 MAPK1 RPS6KA1 PRKCB FOSB BCAR1 HCK CRKL PRKCD PRKD1 CDK2 BCL10 SLA2 ELK1 TCL1A PIP4K2A PIP4K2B PIP4K2C PLCG1 GTF2I MAPKAPK2 BTK LYN IFITM3;IFITM2;IFITM1 PRKCQ CCL3L1;CCL3L3;CCL3;CCL18 ITPR2 RASGRP3 NFATC2 CD79B CD79A BTLA CHST15 STAP1 PIP5K1A PIP5K1B GRB2 PIP5K1C NFATC3 CDK7 HNRNPK ITK BCL6 CD22 PIK3CG CASP9 CASP7 BLNK LAT2 BANK1 IKBKB HCLS1 MALT1 CYCS-1 CCL4L2;CCL4L1;CCL4 SH2B2 PTPN18 CD72 PLEKHA1 PLEKHA2 STAT3 BAX VAV1 RAPGEF1 NEDD9 RELA STAT1 CTNNB1 CREB1 AKT1 PTK2 RB1 ATF2 DOK1 CARD11 JUNB ITPR1 PIK3R2 FOXO3 NCK1 CHUK ZAP70 LCK RASA1 JUN SOS1 SOS2 SH3BP2 MAPK14 GSK3B TEC RPS6KB1 PTPN6 TNFALPHA%NETPATH%TNFALPHA TNFalpha IRS1 EGFR EP300 PRKCA STAT5A GTF2I MAPKAPK2 CASP7 BAX RPL4 RPL30 SMARCB1 RPL8 RPL6 DCAF7 PSMD6 TBK1 PSMD7 AKT2 RPS6KA5 PSMD2 PSMD3 DPF2 PSMD1 RPS11 YWHAE RPS13 SMARCC1 SMARCC2 PSMC2-1 CDC34 CDC37 KCNQ1 TXNIP TRIB3 TXN IQGAP2 GLG1 FADD CRADD SMARCA4 REL FAF1 SMPD3 NKIRAS1 CASP10 NKIRAS2 RFK RACK1 IKBKG IKBKE RIPK3 CREB1 ACTL6A HDAC1 GAB1 HSPB1 AKT1 COMMD1 TAX1BP1 PTK2 CSNK2A1;CSNK2A3 RB1 AKAP8 XIAP TANK RELB PSMB5 RXRA FLNA BID MAP3K2 MAP3K3 ELP1 DIABLO-1 LRPPRC KTN1 BTRC ITCH JUNB PSMC3 PSMC1 SKP1 PKN1 PDK1 CCNT1 ZFAND5 TNF FBL PAPOLA KPNA6 TNFRSF8 KPNA2 KPNA3 MAP3K5 UNC5CL FBXW11 FBXW7 USP2 CYBA TRPC4AP TXLNA FANCD2 NUPR1 FKBP5 NSMAF COPB2 PSMD12 PSMD13 TNFRSF11A RASAL2 BAG4 BRINP1 CUL1 NLRP4 G3BP2 MAP2K5 MARK2 ZBTB17 MCC CDK9 COPS3 BCL3 ALPL TAB3 TAB2 MAP2K6 NFKBIE TRAP1 MAP3K11 BCL2L1 RNF11 MCM7 JUN YWHAB PPP6C BCL7A PPP1R13L UBE2I CASP3 NFKBIZ CASP2 YWHAG YWHAH CAV1 HSP90AA1 PPP1R12A PEG3 TNFRSF1B TRAF7 RASA3 TRAF4 POLR1A POLR1B TRAF6 POLR1C TRAF5 POLR1D POLR1E MCM5 TAB1 PFDN2 BIRC2 BIRC3 HDAC2 USP11 MTIF2 NR2C2 HDAC6 UBE2D3-1 MAPK9 ERBB3 TIFA ROMO1 SUMO1 POLR2H RFFL POLR2L SMARCE1 SPAG9 FOXO1-1 RNF25 CFLAR GLB1 TNIP2 PRC1 PDCD2 TBKBP1 TRIM32 MAPK1 MAPK3 UBE2D3;UBE2D2 PML CREBBP GRB2 PAK1 DDX3X-1 STAT1 MAP3K8 DOK1 NFKB1 NFKBIA HSP90AB1 YWHAQ YWHAZ SOS1 SOS2 SRC MAPK8 PTPN11 MAPK14 ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin PAK1 SHC1-1 FOS IRS1 ERBIN EGFR RTKN ITGB4 PIK3CD ERBB2 LAMC2 EIF4EBP1 IRS2 FYN LAMC1 PIK3CA EIF4E PIK3CB MYLK3 RAC1 EPHB2 AR DSP DST GAB1 RPSA AKT1 RHOA ITGA6 PIK3R1 MET PTK2 PLEC MAPK1 COL17A1 LAMA5 CD151 MAPK3 LAMA2 LAMA3 PIK3R3 MST1R NTN1 SMAD2;SMAD3 CLCA1 SFN PRKCA LAMB3 BAD LAMB2 LAMB1 EIF6 VIM ABL1 PRKCD YES1 MTOR YWHAQ PIK3R2 YWHAZ GRB2 YWHAB JUN PIK3CG CASP3 YWHAH SRC PTPN11 MAPK14 TP73 YWHAE WNT%NETPATH%WNT Wnt ARRB2 PRKACA-1 RAC1 AKT1 RHOA CCND1 PRKCB PRKCA PPP2CB;PPP2CA CHD7 DIXDC1 SOX1 CDH1 MAP3K7 PRKCG WNT5A AXIN1 PRKCD KREMEN1 YES1 DKK1 PAX2 SFRP1 SFRP2 DAAM1 ARHGEF4 ROR1 PI4K2A LRP1 CTBP1 LEF1 LRP5 NLK MESD FRZB GPC3 DVL3 WNT1 WNT2 WNT3 FZD1 MARK2 SMAD1 TCF7L2 JUP NFATC2 FZD5 SETDB1 CSNK1A1 FZD4 FZD7 FZD6 PIP5K1B FZD9 PPP1CA BCL9 PIN1 TCF4 YWHAB JUN MAPK8 CDK6 IL6%NETPATH%IL6 IL6 SHC1-1 NCOA1 FOXO1-1 FOS STAT1 ERBB2 EIF4EBP1 FYN EIF4E JAK1 RAC1 AR HDAC1 HSPB1 GAB1 AKT1 PIK3R1 RB1 MAPK1 MAPK3 EP300 BAD FGR HCK DAXX MAP3K7 STAT5A STAT5B NFKB1 PRKCD NLK PLCG1 BTK LYN PIK3R2 FOXO4 FOXO3 CREBBP CDK9 MAP2K6 GRB2 CD40 JUN SGK1-1 IL6R MAP3K4 EIF2A PIAS3 MAP2K4 TYK2 HNRNPA1-1 HSP90AA1 IL6ST SOCS3 CBL BMX IL6 MAPK8 STAT3 PTK2B GAB2 PTPN11 VAV1 MAPK14 MAP2K2;MAP2K1 GSK3B RPS6KB1 ERBB3 TSH%NETPATH%TSH TSH IKBKB ATP1A1 RAF1 HSPA5 CALR-1 GNAI3 SCRIB IGF1R TSHR GNAI1 GNAS-1 GNAI2 MAP2K3 GNAO1 GNA13 GNA11 CANX GNA12 CREB1 MAP2K6 GNAQ LEP MAPK3 EGFR1%NETPATH%EGFR1 EGFR1 EPHB1 EPHB4 TNS2 TNS1 EPHB3 EPHA4 ACTN1 KRT8 KRT7 KRT5 ACTN4 GAREM1 TAGLN2 PFN1 TLN1 RIN1 EPHA1 EPHA2 SDC4 ASAP3-1 SDC3 MYL12B RACGAP1 RALGDS SNX5 INSR STAM SMU1 SPART SDC1 CC2D1A PTPRR HIP1 AP2A1 PTPRK WASL LIMD1 PTPRF OTUD6B GIT1 NCOA3 RALBP1-1 MINK1 IL17RD CTTN ALDOA ARHGEF5 CSTB PRKX SH3BGRL PDZD11 CDV3-1 CD59 MAP4K5 UBB;UBC CAVIN1 CAVIN2 PLEKHA5 HUWE1 PLEKHA6 ATP5F1C CALM3;CALM1 KRT18 KRT17 AXL NEDD4 EPPK1 ESYT1 TJP2 SH3GL3 INPPL1 PEBP1 ARHGAP42 PDGFRB APLP2 EEF1A1 ADAM17 EEF1A2 ELMO2 VCL DDX6 DAPP1 PLD1 LPP PLD2 EFNB2 CALD1 RIPK1 CAV2 CRIM1 ARHGAP32 DLG3 ACTR3-1 DYRK3 DOCK4 USP31 FLOT1 KLF11 LSR ARAP1 EPN1 EPN2 EPN3 ACTA2 ELF3 MYH9 DOCK1 GRB14-1 RALB RGS16 MVP ASAP1 PDLIM1 MARVELD2 REPS2 MTA2 MAP2K2;MAP2K1 PDLIM4 SNCA EGF SPRY4 HSPE1 TNIP1 SPRY3 APPL1 SPRY2 KRAS SPRY1 ZPR1 DYRK1A CREB1 HDAC1 PIK3R1 PTK2 STK11 MYC MAP2K3 ZFYVE16 TP53 PIK3R2 FOXO4 JUN JUND CAV1 DAB2 SP1 GSK3B PDPK1 FOXO1-1 FOS PIK3CA CRK MAPK1 AP2B1 ITSN2 TFRC CBLB CRKL UBASH3B PRKCD PARD3 PRKD1 PTTG1IP LDHA PLCG2 PLCG1 LYN VASP CLTC SHB PGAM1 VAV1 VAV2 ARHGEF7 NEDD9 RELA PAK1 FLNB MPZL1 DDX3X-1 GIT2 ERBIN ARHGAP35 KIRREL1 DYRK1B PRPF4B DOK1 DOK2 ADAM9 PKP4 RAF1 KHDRBS1 SDCBP CASKIN2 ABL1 NFKB1 PTPRA CDK1 PIK3C2B ACP1 NCK1 YWHAZ PKM LCK CEBPB ATP1A1 MAPK8 MAPK7 PTK2B PTPN12 MAPK14 RPS6KB1 PTPN6 PRKAA1 GSK3A PRKAA2 EGFR RPS6KA2 ERBB2 EIF4EBP1 FYN JAK1 SH2B1 NOS3 CDK5 SH3KBP1 RPS6KA1 JAK2 HRAS PRKCA KIT GRB7 SOCS1 STAT5A STAT5B MTOR CDK2 ELK1 PIK3CG CASP9 PTPN18 RPL30 RPS6KA5 GAB1 MAP3K3 ITCH YWHAB MAPK9 ERBB3 ITGB4 PIK3CD IRS2 PIK3CB RAC1 EPHB2 DSP RHOA MET PLEC COL17A1 PIK3R3 SMAD2;SMAD3 BAD VIM CDH1 PRKCG ARHGEF4 CTBP1 JUP MAP3K4 PIAS3 TYK2 HNRNPA1-1 SOCS3 SCRIB USP6NL ATF1 ARAF HNRNPR ENO1 ELK4 GJA1 TFG MPRIP ANKS1A TGIF1-1 PRKCI FRS2 FRS3 KIAA1217 PRKAR1A KRT6B;KRT6C;KRT6A RBCK1 SERPINB3;SERPINB4-1 IQGAP1 SLC5A5 ANTXR1-1 MYO6 S100A14 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 S100A11 S100A10 AFAP1L2 RBM3-2 BRAF CYLD TOLLIP TRIP6 PYGB RPLP0 CLTA ARHGAP5 ENSA PLEKHN1 APPL2 ANXA1 ANXA4 EPS15L1 PLSCR1 GPRC5A TKT PHLPP1 AHNAK RPS27L HTT SNX33 AP2S1 STX4 RICTOR RPS2 LDLR GSN MCF2 STAT2 HIPK3 DCBLD2 HIPK2 PKN2 FRK CTNND1 ARF4-1 C11orf52 LAPTM4A CYSRT1 CDH3 CDH2 CFL1 TOM1 GRB10 MAGI1 DYRK4-1 TOM1L1 TOM1L2 HAT1 PKP2 STAMBP PKP3 PHPT1 PHLDB2 SIRPA;SIRPB1;SIRPG STIP1 ATXN2 ITLN2;ITLN1-2 HNRNPDL ABL2 MAP2K7 SLC38A2 TNK2 PTPRE ACTB-1 ALB BCL2 RAB5A MAP3K14 EIF4G1 ITGB1 BCAR3 CALCOCO2 PTEN PTPN23 NCK2 SFPQ-1 CCDC50 ACTR2 PDCD6IP ITGA3 DSG2 SLC25A6 CEBPA WBP2 SRI CDC42 SLITRK6 CSK RBBP7 CTNNAL1 PTPN1 PPP1R14B BAIAP2 NECTIN1 ERRFI1 APP AHCYL1 PITPNA ZDHHC5 CBLC RPS6KA3 BAIAP2L1 SNRPD2 TRIM29 TNS4 RPS10 TNS3 SLC12A7 ID%NETPATH%ID ID FHL2 PAX5 ELK3 ELK1 RBL1 PSMD4 ATF3 SMAD2;SMAD3 ID3 RAF1 HES1 MYF5 RBL2 TCF7L2 MAP2K2;MAP2K1 ELK4 RB1 MAPK1 SMURF2 CDK2 MAPK3 IL9%NETPATH%IL9 IL9 TYK2 STAT5A STAT5B KAT5 STAT6 IL9R MAPK1 MAPK3 IL3%NETPATH%IL3 IL3 SHC1-1 GSK3A PRKACA-1 INPP5D FOXO1-1 LYN SLC2A1 PIK3R2 GATA2 SOCS2 PIK3CD BCL2L11 KCNIP3 IL3 RARA CRK RACK1 YWHAZ CREB1 GAB1 BCL2L1 PIK3R1 YWHAB PTK2 MAPK1 DOK1 RXRA SOCS3 HRAS PRKCB PRKCA BAD PPP2CB;PPP2CA CSF2RB CRKL GAB2 MAP2K2;MAP2K1 ATF1 GSK3B NFKB1 PTPRC PTPN6 FES IL5%NETPATH%IL5 IL5 SHC1-1 GSK3A ELK1 STAT1 LYN FOXO3 IL5RA ALOX5 RACK1 JAK1 YWHAZ CTNNB1 SOX4 DNM2 PLA2G4A UNC119 IL5 GRB2 IL2RB JUN ATF2 PIK3CG SOS1 RPS6KA1 HCLS1 HRAS RAF1 CBL HCK SYK STAT3 PTK2B BAX SDCBP CRKL SOCS1 PTPN11 MAPK14 MAP2K2;MAP2K1 STAT5A GSK3B STAT5B NFKB1 PRKCD NFKBIA RAPGEF1 IL4%NETPATH%IL4 IL4 SHC1-1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PIK3CD IRS2 PIK3CA JAK1 SPI1 AKT1 IL13RA1 IL13 STAM SND1 PTK2 CXCR4 MAPK1 ATF2 IL2RG GRK3 MAPK3 IL4 ETS1 EP300 JAK2 NCOA3 BAD SOCS1 NFKB1 PRKCD NFKBIA ELK1 INPP5D PLCG2 CREBBP CHUK RASA1 CD40 TYK2 CEBPB IKBKB CEBPA CBL MAPK8 SYK STAT3 PTPN11 MAPK14 MAPK11 RPS6KB1 PTPN6 IL-7%NETPATH%IL-7 IL-7 IL7 IL7R SHC1-1 GSK3A FOXO1-1 STAT1 IRS1 JAK3 BAD STAT3 FOXO3 CBLB IRS2 FYN MAP2K2;MAP2K1 STAT5A STAT5B GSK3B AKT1 PIK3R1 STAM MAPK1 IL2RG MAPK3 NOTCH%NETPATH%NOTCH Notch HES1 KAT2B AKT1 PIK3R1 MAPK1 MAPK3 MAML2 MAML1 FHL1 EP300 RBPJ JAK2 LFNG SMAD2;SMAD3 YY1 SIN3A CCN3 CIR1 SKP2 PSENEN HES6 SKP1 RING1 SAP30 NCOR2 NCOR1 MFNG MAML3 NOTCH2 NOTCH4 PSEN2 DTX1 NFKB1 FURIN DLL3 RBX1 APH1A FBXW7 DLL4 MAGEA4;MAGEA1;MAGEA3;MAGEA2;MAGEA2B;MAGEA12;MAGEA6;MAGEA10-MAGEA5;MAGEA5;MAGEA9B;MAGEA9;MAGEA8;MAGEA11 NCSTN APH1B SPEN JAG2 LEF1 CUL1 SMAD1 SRC SNW1 STAT3 APP GSK3B HDAC2 RELA IL2%NETPATH%IL2 IL2 SHC1-1 IRS1 PIK3CD EIF4EBP1 IRS2 FYN PIK3CA EIF4E PIK3CB CRK JAK1 CREB1 RPS6 IL2RB AKT1 PIK3R1 STAM MAPK1 ATF2 IL2RG MAPK3 ETS1 PIK3R3 RAF1 STAM2 CRKL STAT5A STAT5B NFKB1 MTOR CCNE1 CDK2 YBX1 NR3C1 ETS2 ELK1 IL15 PLCB1 PRKCZ TERT MKNK1 STAT4 NMI LYN IL2 PIK3R2 VIL1 IL2RA FOXO3 ITM2B EIF3B BCL2 GRB2 LCK JUN SGK1-1 PIK3CG SOS1 SHB HSP90AA1 SOCS3 CBL JAK3 MAPK8 PTK2B GAB2 PTPN11 VAV1 MAPK14 MAP2K2;MAP2K1 PTPN6 RELA TSLP%NETPATH%TSLP TSLP STAT1 STAT4 STAT6 MAPK8 STAT3 NFKB2 EIF4E MAPK14 MAP2K2;MAP2K1 STAT5A STAT5B NFKB1 NFKBIA AKT1 MAPK9 MAPK1 RELA RELB MAPK3 RANKL%NETPATH%RANKL RANKL MITF MAPK8 REL TRAF6 NFKB2 TRAF5 CHUK TRAF2 TNFRSF11B TREM2 TRAF1 MAPK14 TAB1 MAP3K7 TRAF3 TNFSF11 TAB2 NFKB1 ATP6V1E1 SQSTM1 SPI1 PTK2 IL1%NETPATH%IL1 IL1 PIK3R2 REL CHUK TOLLIP TAB3 PLA2G4A TAB2 MAP2K6 MAP3K14 IL1RN PELI2 AKT1 PIK3R1 IRAK1 IRAK2 JUN RB1 PPP6C MAPK1 FBXW5 ATF2 IL1R1 IL1R2 DOK1 MAPK3 IRAK3 IRAK4 SOD1 IL1A IKBKB IL1B MAP3K2 PELI1 UBE2N ELP1 UBE2V1 MYD88 MAPK8 TRAF6 MAP2K3 MAPK14 TAB1 NFKB1 NFKBIA MAPK9 RELA ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis ILVBL BCAT1 BCAT2 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway RPIA GPI HKDC1 TALDO1 PGD TKT HK2 HK1 ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation FAAH FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis MTHFD1L MTHFD2 MTR-1 TYMS DHFR2;DHFR FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism ALDOC ALDOB HKDC1 ALDOA KHK HK2 HK1 GALE GALT P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway MAP3K4 MAP2K6 MAP2K4 MEF2C IL1R1 MAPK14 MEF2B;BORCS8-MEF2B MAPK12 MAPK13 MAPK11 MAPKAPK3 TRAF6 MAPKAPK2 MAP3K10 TAB2 TAB1 ATF1 SRF HSPB1 ELK1 RPS6KA4 EEF2K RPS6KA5 MKNK1 MKNK2 EIF4E MEF2D MAP3K7 VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway PLCG1 MAPK3 NOS3 BRAF PTK2 VEGFA HSPB1 MAPK14 MAPKAPK3 MAPKAPK2 PRR5 TGFB1I1 ARAF ARHGAP1 PIK3CD PIK3CB PIK3C2A ETS1 PIK3CG PIK3C2B CASP9 ARHGAP8;PRR5-ARHGAP8 KDR RAC3 AKT1 RAC1 HRAS PRKCG PRKCI PRKCH PRKCB SPHK2 SPHK1 PRKCE PRKCD PLA2G4A PRKCA PIK3CA PRKD3 PRKD2 PIK3C3 PRKCQ PRKD1 RAF1 CRYAA;CRYAA2 CRYAB SHC2 PXN PIK3R3 PIK3R2 PIK3R1 HIF1A PRKCZ NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 LPXN INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway MAPK3 NOS3 BRAF IL21 GSK3B CDKN1A CXCL8 SPI1 CDKN1B IRS1 IL5RA IRS2 SLA2 ELK3 IKBKB ELK4 RPS6KA3 SPIC RPS6KA6 AKT2 RPS6KA2 MYC RPS6KA1 AKT3 IL13RA2 JAK3 IL6R IL13RA1 IL10 IL11 IL4R CHUK IL15 PDPK1 IL11RA IL13 IL18 FOS IL1A IL23A IL3RA SOS1 IL6ST SOS2 IL20RA FOXO3 MAPK7 CXCR1 CXCR2 STAT4 SRF STAT6 MAPK6 ELK1 IL12RB1 IL12RB2 STAT5A STAT5B MKNK1 STAT1 MKNK2 IL10RB STAT2 IL10RA STAT3 MAPK15 MTOR IL2 IL4 IL6 IL5 IL7 IL2RA IL9 IL2RB SHC1-1 MAPKAPK2 ARAF PIK3CB AKT1 PIK3CA RAF1 NRAS MAPK1 FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis FLAD1 RFK HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis EPRS1 UROD RSAD1 HMBS CPOX PPOX EARS2 COX10 ALAD QARS1 FECH NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway CHRNA3 KCNK9 CHRNA5 EPB41 CHRNA4 CHRNA6 ADCY2 CACNA1C GNAI1 CACNA1G PRKACA-1 GNG2 EPB41L1 EPB41L2 FLNA DRD2 DRD4 SLC18A2 CHRNB2 CHRNB4 CHRNB3 PPP1CA PPP1R1B GNB1 KCNK3 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system PER2 PER1 CRY2 CRY1 TPTEP2-CSNK1E;CSNK1E CSNK1D CLOCK ARNTL CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis MVD PDSS1 HMGCR LSS FDFT1 HMGCS1-1 FDPS SQLE MVK GGPS1 IDI2 PMVK IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway GRIA1 GRIA2 SNAP25 STX19 GRIK5 SLC1A1 SNAP23 GRIK3 SLC1A2 GRIK4 SLC1A3 GRIK1 GRIK2 SLC1A6 SLC1A7 STX11 GRM3 GRM2 GRIN2A SLC17A6 SLC17A8 SNAP29 GRIA3 GRIA4 GRIN2C GRIN2B GRIN2D GRIN1 VAMP8 GRIN3A VAMP1 SHANK3 VAMP2 SHANK1 VAMP3 PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis PSAT1 PNPO CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle CCND3 CCND2 CCNE1 RPA3 CINP P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 MAPK14 MAPK12 CDKN1A MAPK13 MAPK11 PIK3CD PIK3CB PIK3C2A AKT2 PIK3CG PIK3C2B AKT3 AKT1 HRAS PDPK1 PIK3CA CCNE1 PIK3C3 RB1 PPP2CB;PPP2CA PTEN PIK3C2G PIK3R5 TP63 SIAH1 PIK3R3 TPTE;TPTE2 PIK3R2 RBL1 PIK3R1 CDK2 CCNG1 CTNNB1 NRAS ATM KRAS TP53 TP73 ATR THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis THNSL1 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation ABAT HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway PLCG1 ITPR1 ITPR2 ITPR3 GNA14 GNG10 HRH1 GNG5 PLCZ1 GNG4 GNA11 GNG8 PLCE1 PLCL1 PLCB3 PLCB4 GNB2 GNAQ GNB4 GNB3 GNB5 PLCB1 PLCB2 PLCD4 PLCD1 PRKCG PRKCI GNG2 PRKCH PRKCB PRKCE PRKCD PRKCA GNB1 PRKCQ PRKCZ PLCG2 METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway GRIN1 PRKAR1A GRINA ITPR1 PRKACA-1 GRIN3A PRKCB GRIK5 GNA11 GRIK1 PLCB4 GNAQ GRIN2A HOMER1 PRKX GRM1 GRIN2C PRKACB-1 GRIN2B GRM5 GRIN2D PRKAR1B OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response MAP2K6 MAP2K3 MAP2K4 JUN MEF2C MAX TXN MAPK14 MAPK9 MAPK12 MAPK8 MAPK13 DDIT3 PLA2G4A MAPK11 BCL2 ELK1 MYC EEF2K STAT1 MKNK1 MKNK2 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway GNG10 GNG5 GNG4 GNG8 GNB2 GNB4 GNB3 GNB5 KCNK9 PRKX PRKACB-1 ADCY2 GNAI1 PRKACA-1 GNG2 GNAI3 ADCY7 GNAI2 PRKAR2B PRKAR2A HTR1E GNB1 HTR1F KCNK3 HTR1D HTR1A HTR1B GNAO1 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway PLCG1 GNA14 GNG10 GNG5 PLCZ1 GNG4 GNA11 GNG8 PLCE1 PLCL1 PLCB3 PLCB4 GNB2 GNAQ GNB4 GNB3 GNB5 PLCB1 PLCB2 PLCD4 PLCD1 PRKCG PRKCI GNG2 PRKCH PRKCB PRKCE PRKCD PRKCA GNB1 PRKCQ OXTR PRKCZ PLCG2 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway GNG2 GNG10 GNG5 GNG4 ADCY7 GNG8 GNB1 GNB2 GNB4 GNB3 GNB5 HTR4 GNAL ADCY2 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling GABBR2 GABBR1 ADCY9 GNG5 GNG4 GNG8 GNB2 GNB4 GNB3 PRKACB-1 ADCY2 PRKAR1B GNAI1 PRKAR1A CACNA1G PRKACA-1 GNAI3 ADCY7 PRKAR2B PRKAR2A GNB1 GNAO1 ADCY4 CACNA1B CACNA1A ADCY1 ADCY8 ADCY6 ADCY5 KCNJ3 UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway UBA7 UBE2B UBE2D4 UBA6 UBE2C UBE2E3 UBE2E1 UBE2D1 UBE2E2 UBE2G1 UBE2L6 UBE2G2 UBE2D3;UBE2D2 UBE2D3-1 UBE2S UBE2T UBE2N UBE2V2 UBA3 UBA2 UBA1 SAE1 ATG7 UBE2K ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway GSK3B APP ACTC1;ACTG2 WNT2B FZD10 RBPJ ACTG1 CDH3 KAT5 CDH1 TRIM2 TRIM3 TRPC7 PSENEN ACTR2 TRPC5 TRPC6 WNT5B TRPC4 TRPC1 WNT5A WNT9B WNT9A WNT16 ERN1 ACTA2 BACE1 ACTA1 BACE2 ACTBL2 CD44 RBPJL NOTCH2 CTNNB1 NOTCH3 NOTCH1 LRP1 NOTCH4 LEF1 LRP5 WNT8A PSEN2 WNT8B LRP4 LRP3 PSEN1 LRP2 FSTL1 LRP6 WNT6 NCSTN WNT11 APH1B ERBB4 DVL1 DVL2 DVL3 APBB2 WNT1 WNT2 APBB3 WNT3 WNT4 FZD1 TCF7L2 WNT10B TCF7L1 WNT10A FZD3 FZD2 JUP FZD5 WNT3A FZD4 WNT7B FZD7 FZD6 FZD9 FZD8 WNT7A LRP1B AFDN ACTB-1 NECTIN1 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation ALDH1L1 MAOB MAOA ALDH1L2 ALDH4A1 ALDH3A2 ALDH3A1 ALDH1A3 IL4I1 ALDH1B1 ALDH3B2;ALDH3B1 ALDH2 ALDH1A2 ALDH1A1 ALDH16A1 ALDH8A1 ALDH7A1 ALDH9A1 P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 MDM2-2 MDM4 TP63 TP53 TP73 COP1 VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis ILVBL BCAT1 BCAT2 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization ACSS3 ACSS2 ACSS1 COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis PANK4 PANK3 PANK1 PPCS DCAKD METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle IREB2 ACO1 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation MAPK3 PPP3CA PPP3CB BLNK VAV3 SYK IKBKB NFKBIL1 VAV1 VAV2 BTK CD79B CD79A CD19 LYN MAP3K2 MAP3K3 CALM3;CALM1 NFKBIA MAPK10 PTPRC PTPN6 GRB2 CD22 CHUK FOS SOS1 SOS2 ITPR1 ITPR2 ITPR3 MAPK14 MAPK12 MAPK13 MAPK11 ARAF PIK3CD PIK3CB PIK3CG RAC1 HRAS JUN PRKCB MAPK9 MAPK8 PRKCD PIK3CA RAF1 NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation IGBP1 PRKAB2 PRKAA1 PRKAA2 PRKAG1 TSC2 TSC1 PRKAB1 RPS6KB1 RHEB RPS6KB2 EIF4EBP1 PPP2CB;PPP2CA TP63 AKT2 AKT3 TP53 AKT1 TP73 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis LPL PLA1A PLCB1 PLCB2 DAGLA PLCB3 LIPH MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism GMPPB PMM1 GMDS GMPPA PMM2 MPI MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing SNRNP40 PRPF3 SNRPB2 ZRSR2-1 SNRPA HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation EGLN2 RORC MTOR ARNT TXN2 VHL TXN AKT2 HIF1A AKT3 EGLN1 CREBBP AKT1 EGLN3 THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism THTPA TPK1 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor GTF2A1 GTF2A2 GTF2B TAF9 TTF2 TTF1 GTF2E1 GTF2E2 PSMC3IP CREB3L3 CREB3L4 TAF1C CREB3L1 POLR2C CREB3L2 POLR2E POLR2F EP300 POLR2H TAF9B CFAP20 POLR2L TBP BRF2 TAF12 PRKAR1B BRF1 PRKAR1A MTERF2 TAF11 GTF2H1 GTF2F1 GTF2H3 GTF2F2 GTF2H4 TBPL2 TAF8 TAF7 TBPL1 TAF6 PRKAR2B TAF4 PRKAR2A TAF2 CREB5 CREBBP OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway GNAI1 GNG2 GNG10 GNG5 GNAI3 GNG4 ADCY7 GNAI2 GNG8 GNB1 OPRD1 POMC GNB2 GNB4 GNAO1 GNB3 GNB5 ADCY2 BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation CYP2B6 O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis TGDS GFPT2 GFPT1 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis AVP OXT-1 GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion LGSN GLUL GLUD1;GLUD2 UNTITLED%PANTHER PATHWAY%P00019 untitled GUCY1A2 EDN1 MAPK3 GUCY1A1 ADCY9 NOS3 EDN2 EDN3 GNAS-1 ADCY3 ADCY10 AKT2 AKT3 ITPR1 ITPR2 ITPR3 GNA14 GNA11 PLCB3 PLCB4 ARAF GNAQ PLCB1 PLCB2 PRKACB-1 AKT1 ADCY2 PRKAR1B PRKAR1A PRKCG PRKACA-1 PRKCI PRKCH PRKCB PRKCE PRKCD PLA2G4A PRKCA ADCY7 PRKAR2B PRKAR2A PRKCQ RAF1 GNAL ADCY4 PRKCZ GUCY1B1 ADCY1 EDNRA ADCY8 MAP2K2;MAP2K1 EDNRB ADCY6 PRKG2 ADCY5 MAPK1 PRKG1 HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis HDC TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis GCH1 FPGS TYMS DHFR2;DHFR 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway PLCG1 GNA14 GNG10 GNG5 PLCZ1 GNG4 HTR2B GNA11 HTR2A GNG8 PLCE1 PLCL1 PLCB3 PLCB4 GNB2 GNAQ GNB4 GNB3 GNB5 PLCB1 PLCB2 PLCD4 PLCD1 PRKCG PRKCI GNG2 PRKCH PRKCB PRKCE PRKCD PRKCA GNB1 PRKCQ PRKCZ PLCG2 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway CSK LAMB3 LAMB2 LAMB4 LAMB1 PTPN12 COL3A1 LIMS2 BCAR1 MAP3K2 MAP3K3 MAPK10 MAP3K4 MAP2K4 MAPK13 ARAF PIK3CD PIK3CB PIK3C2A PIK3CG PIK3C2B RAC1 HRAS MAP2K3 MAPK9 MAPK8 PIK3CA PIK3C3 RAF1 PXN PIK3R3 PIK3R2 PIK3R1 NRAS MAP2K2;MAP2K1 MAPK3 BRAF PTK2 COL16A1 COL12A1 ITGA2B ARPC5L CRKL MAP3K5 COL27A1 ACTN2 ACTN1 ACTN4 COL4A2 COL4A1 COL4A4 COL4A3 COL4A6 ELMO1 COL8A2 COL4A5 ELMO2 ACTG1 COL8A1 TLN1 VCL COL17A1 COL13A1 ARL1 DNAJC27 RAP1B RAP1A RRAS VASP CAV1 FN1 SOS1 PARVA PARVB SOS2 ARPC5 ARHGAP26 COL1A2 LIMS4;LIMS1 ARPC2 COL5A1 ARPC3 ITGA10 MAPK6 COL5A3 ACTBL2 ITGA11 COL5A2 COL20A1 COL9A1 ITGBL1 COL9A3 COL9A2 ITGB1 ARF1 ITGAM ITGB5 ITGB4 COL14A1 LAMC3 ARPC1B ARPC1A ITGB2 ILK LAMC2 SHC1-1 LAMC1 ITGAE RND2 ITGAL RND3 RND1 ITGAX COL10A1 ITGB8 ITGAV ITGB7 ITGB6 ITGA4 ITGA3 ITGA2 ITGA1 RHOC ARFGAP1 RHOA RHOB ARHGAP10 RAP2A COL2A1 RAP2B ITGAD COL6A2 COL6A1 ITGA8 FLNA RAPGEF1 ITGA7 COL6A3 ITGA6 ACTB-1 ITGA5 CRK DOCK1 ARF6 ITGA9 LAMA5 COL15A1 LAMA2 LAMA1 SRC LAMA4 COL11A1 LAMA3 COL11A2 NTN4 ASAP1 CDC42 MICALL1 PTK2B FLNB FYN PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway EHF ARHGAP42 OPHN1 GRAP2 PDGFRB PDGFRA PDGFRL VAV3 ERF ERG SHC3 VAV1 PDGFB VAV2 PDGFA ARHGAP15 ARHGAP12 SRGAP3 SRGAP1 FLI1 MAP3K2 FEV GRAP ARHGAP9 GSK3A MAPK10 ARHGAP5 ARHGAP6 GRB2 RERG ARHGAP4 RASA4;RASA4B NCK2 JAK2 GABPA JAK1 NCK1 GAB1 GAB2 ETV3 RPS6KB1 ELF1 ELF2 RPS6KB2 ELF3 ELF4 ELF5 RASA1 RASA2 RPS6KC1 PIK3R5 SPDEF MYCBP-1 SRF ELP1 USF2 ELK1 RAB11B RPS6KA4 NIN PKN2 RPS6KA5 MKNK1 MKNK2 MAP3K4 ITPR1 ITPR2 ITPR3 MAPKAPK2 ARAF ARHGAP1 PIK3CD PIK3CB ETS1 PIK3CG ARHGAP8;PRR5-ARHGAP8 HRAS JUN MAPK8 PRKCA PIK3CA PIK3C3 RAF1 SHC2 PIK3R3 PIK3R2 PIK3R1 NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 PLCG1 MAPK3 BRAF GSK3B IKBKB ELK4 RPS6KA3 RPS6KA6 AKT2 RPS6KA2 MYC RPS6KA1 JAK3 CHUK PDPK1 FOS SOS1 SOS2 ARHGAP26 MAPK7 STAT4 STAT6 MAPK6 STAT5A STAT5B STAT1 STAT2 STAT3 MAPK15 SHC1-1 ARHGAP10 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway ACTC1;ACTG2 ACTG1 ACTA2 ACTA1 ACTBL2 SLC44A3 ACTR1A ACTR1B MYO18B MYO18A SLC18A3 CHRNB1 MYO7B MYO7A SLC5A7 MYH1 MYH3 MYO3B MYO3A MYH8 MYH9 MYH6 MYH7 CHRNA1 PLEKHH3 CHRNA9 CHRNA7;CHRFAM7A CHRNA2-1 CHRND CHRNG CHRNE MYO6 MYH13 MYH14 CHRNA10 CHRNA3 MYH11 MYH10 CHRNA5 MYH7B MYO10 CHRNA4 MYO5A CHRNA6 MYO19 MYO1G;MYO1D MYO9A MYO16 MYO1E MYO1B SLC6A8 MYO1C MYO1A MYO15A MYO5B MYO5C MYO1F CHRNB2 CHRNB4 ACTB-1 CHRNB3 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway STAT4 JAK2 STAT6 JAK1 STAT5A STAT5B STAT1 JAK3 STAT3 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism SUGCT SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis PSAT1 PHGDH PSPH AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin PLCG1 PIK3CD PIK3CB PIK3C2A PIK3CG PIK3C2B RAC1 VASP PIK3CA NTN1 NTN3 ABLIM1 NTNG1 NTNG2 UNC5B PIK3R5 DCC NFATC3 NFATC2 PIK3R3 UNC5C PIK3R2 UNC5D PIK3R1 NFATC4 NTN4 RHOU CDC42 PLCG2 ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis SLC18A1 SLC6A2 SLC6A3 SLC18A2 SLC6A19 SLC6A18 SLC6A17 SLC6A16 SLC6A15 SLC6A20 NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation CYP2A13;CYP2A6;CYP2A7-1 FMO3 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 INMT COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism SUGCT S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis MAT2A MAT1A MTR-1 CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase MYLK2 BUB1B-PAK6;PAK6 STMN4 WASL MYLK3 MYLK CFL2 CFL1 STMN1 TUBB1 TUBB2B;TUBB2A PFN1 PFN2-1 TUBB3;TUBB6 PFN3 ROCK1 ROCK2 PAK1 PAK3 ACTC1;ACTG2 PAK2 PAK5 PAK4 LIMK1 ACTG1 ARPC4 TUBB4B DIAPH1 DIAPH2 TUBB4A;TUBB;TUBB8B;TUBB8 ARPC5 ACTA2 ARPC2 ACTA1 ARPC3 ACTBL2 MYH1 MYH3 ARPC1B MYO3B ARPC1A MYO3A MYH8 MYH9 MYH6 MYH7 MYH13 MYH14 MYH11 MYH10 MYH7B RHOC RAC1 ACTB-1 RHOU CDC42 INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade MAPK3 IRS1 IRS2 RPS6KA3 RPS6KA6 RPS6KA2 RPS6KA1 MAP2K3 IRS4 IGF1R INS;INS-IGF2 INSR FOS INSRR IGF2 RPS6KB1 IGF1 IGF2R RPS6KB2 SOS1 SOS2 RASA1 RAF1 ELK1 RPS6KA4 RPS6KA5 MAP2K2;MAP2K1 MAPK1 INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway JAK2 JAK1 STAT1 IFNG IFNGR1 IFNGR2 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis TPH2 DDC TPH1 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides UCK1 NME4-1 NME2 NME3 UPRT UPP1 ADAT2 UCKL1 METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway GRIA1 GRIA2 SNAP25 ADCY10 GRIK5 SLC1A1 SNAP23 GRIK3 SLC1A2 GRIK4 SLC1A3 GRIK1 GRIK2 SLC1A6 SLC1A7 GRIN2A SNAP29 GRIA3 GRIA4 GRIN2C GRIN2B GRIN2D GRIN1 VAMP8 GRIN3A VAMP1 VAMP2 VAMP3 GRM4 GRM7 GRM6 GRM8 CACNB1 STX1A CACNA1E VTI1A SLC17A7 GNG10 GNG5 GNG4 GNG8 GNB2 GNB4 GNB3 GNB5 PRKX GRM1 PRKACB-1 GRM5 PRKAR1B PRKAR1A GNAI1 PRKACA-1 GNAI3 GNAI2 PRKAR2B PRKAR2A GNB1 CACNA1B CACNA1A APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway MAPK3 IKBKB MAP3K5 AKT2 AKT3 NFKBIA MAPK10 CHUK FOS IGF2R ATF1 TP53 MAP2K4 ATF2 TRADD FASLG TNF CASP7 CASP8 AIFM1 CASP10 CASP3 TNFSF10 GZMH;GZMB-1 MAP4K2 DAXX ENDOG APAF1 TRAF2 PIK3CD TNFRSF1B PIK3CB TNFRSF1A GZMH-1 MADD PIK3CG LTA LTB CASP9 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A ATF6 ATF3 JDP2 AKT1 BIRC2 ATF4 BIRC3 PRKCG ATF6B MAP2K3 CREM PRKCH XIAP JUN PRKCB RELA RELB CYCS-1 MAPK9 PRKCE MAPK8 BCL2L11 PRKCD RIPK1 BAK1 BCL2 PRKCA FADD PIK3CA MAP2K7 MAP4K3 MAP4K4 MAP3K1 PRKCQ CRADD BIK EIF2AK2 DIABLO-1 EIF2S1 NFKB1 NFKB2 ATF7;ATF7-NPFF PRKRA REL BAX FAS MAP3K14 BCL2L1 MAPK1 LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis BCAT1 BCAT2 RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway EXOC2 RALB MAPK3 PLD1 PLD2 BRAF RALGDS RGL1 GSK3B RPS6KA3 RPS6KA6 RPS6KA2 RPS6KA1 AKT3 PAK1 PAK3 PAK2 GSK3A MAPK10 GRB2 PDPK1 SOS1 SOS2 SRF ELK1 STAT1 KRAS STAT3 MAP3K4 MAP2K6 MAP2K4 ATF2 MAPK14 MAPK12 MAPK13 MAPK11 MAPKAPK3 SHC1-1 MAPKAPK2 ARAF PIK3CD PIK3CB ETS1 PIK3CG RHOC RAC3 RHOA AKT1 RHOB RAC1 HRAS MAP2K3 JUN MAPK9 MAPK8 PIK3CA MAP2K7 PIK3C3 MAP3K1 RAF1 CDC42 NRAS MAP2K2;MAP2K1 MAP3K7CL RALA-1 MAPK1 TIAM1 ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin MAPK3 ITPR1 ITPR2 ITPR3 ARRB1 GNG10 ARRB2 GRK3 GRK2 GNG4 EGR1 AGT GNG8 AGTR1 PLCB3 GNB2 GNAQ GNB4 GNB3 GNB5 PLCB1 PLCB2 PRKCA GNB1 RAF1 ELK1 MAP2K2;MAP2K1 MAPK1 GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation GTF2A1 GTF2A2 GTF2B TAF9 TTF1 GTF2E1 GTF2E2 TAF1C POLR2C POLR2F POLR2H TAF9B CFAP20 BRF2 TAF12 BRF1 MTERF2 TAF11 GTF2H1 GTF2F1 GTF2H3 GTF2F2 GTF2H4 TAF8 TAF7 TBPL1 TAF6 TAF4 TAF2 P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway MDM2-2 MDM4 CDKN1A HDAC1 CCNB1 WRN SUMO1 SIN3A CHEK2 SUMO3 TRAF2 SUMO2 HMGB1-1 AKT2 SFN MTA2 EP300 GTSE1 CDKN2D AKT3 GADD45B CDKN2A GADD45A CDC25C AKT1 SIRT1 PML GADD45G KAT2B KAT6B CDK1 PDPK1 PIK3CA CCNE1 PTEN TP63 TPTE;TPTE2 CDK2 ATM TP53 CREBBP TP73 ATR THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway PLCG1 SNAP25 SNAP23 SNAP29 VAMP8 VAMP1 TRH TSHB VAMP2 TRHR CACNB2 VAMP3 CACNB3 CACNB4 STX3 CGA CACNB1 CACNA1E GNA14 GNG10 GNG5 PLCZ1 GNG4 GNA11 GNG8 PLCE1 PLCL1 PLCB3 PLCB4 GNB2 GNAQ GNB4 GNB3 GNB5 PLCB1 PLCB2 PLCD4 PLCD1 PRKCG PRKCI PRKCH GNG2 PRKCB PRKCE PRKCD PRKCA PRKCQ GNB1 CACNA1B CACNA1A PRKCZ PLCG2 ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis HSD17B3 HSD17B6 HSD17B7 LIPA CYP19A1 SOAT1 SOAT2 HSD17B1 HSD17B2 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway CTNND2 CTNND1 PCDHB9;PCDHB10 CELSR1 CDH9 CELSR2 CTNNB1 CDH8 CELSR3 CDH7 CDH6 CDH5 CDH4 CDH2 PCDHGC4;PCDHGC3 PCDHAC1 PCDHA13 PCDHA11 PCDHA10 PCDHB4-1 PCDH10 PCDH15 PCDH12 PCDH19 PCDH18 PCDHA1 CDH20 CDH22 PCDHA5 CDH23 PCDHA4 CDH24 PCDHA3 PCDHGB5;PCDHGB4 PCDH11X;PCDH11Y PCDH20 PCDHGA10 PCDHGA11 PCDHGA12 FER PCDHB2 PCDHB1 PCDHB11;PCDHB12 PCDHB6 FAT1 FAT2 DCHS1 FAT3 PCDHB3 PCDHB7 PCDHGB7 PCDHGB6 PCDHGB2 PCDHA8;PCDHA6-1 PCDHGA8 PCDHGA7 PCDHGA5 PCDHGA3 PCDHA7;PCDHA9 PCDHGA2 PCDHGA1 CDHR1 CDH10 CDH11 CDHR2 CDH12 PCDHGB1 CDH13 CDH15 CDH16 CDH17 CDH18 CDH19 PCDHB13;PCDHB8 PCDH1 PTPN1 PCDH9 PCDH7 PCDH8 PCDHB15 PCDHB14 PCDHB5-1 PCDHB16 ACTC1;ACTG2 WNT2B FZD10 ACTG1 CDH3 CDH1 ACTR2 WNT5B WNT5A WNT9B WNT9A WNT16 ACTA2 ACTA1 ACTBL2 LEF1 WNT8A WNT8B FSTL1 WNT6 WNT11 WNT1 WNT2 WNT3 WNT4 FZD1 TCF7L2 WNT10B TCF7L1 WNT10A FZD3 FZD2 FZD5 WNT3A FZD4 WNT7B FZD7 FZD6 FZD9 FZD8 WNT7A ACTB-1 UNTITLED%PANTHER PATHWAY%P06664 untitled RELA SKIL TGIF1-1 PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation AOC3 AOC1 AOC2 TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle OGDH SUCLG1 SDHC ACO2 PDK2 CS FH PDHA1 MDH1 ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis ATP5F1B ATP5F1C ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation ODC1 AZIN2 AZIN1-2 SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion PCCB ECHDC1 MMUT LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis LIAS PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism NT5E DPYSL5 ABAT DPYSL2 DPYS DPYD DPYSL3 UPB1 CDA ALDH6A1 ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation RPE;RPEL1 BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway PRKACA-1 GNG2 GNG10 ADRB1 GNG5 GNG4 ADCY7 GNG8 PRKAR2B PRKAR2A GNB1 GNB2 GNB4 GNB3 GNB5 GNAL PRKX PRKACB-1 ADCY2 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade MDM2-2 MDM4 PDPK1 IRS4 IGF1R GSK3B TSC2 INS;INS-IGF2 INSR TSC1 INSRR FOXO1-1 IGF2 IGF1 PIK3CA IRS1 IGF2R IRS2 FOXO3 PTEN TPTE;TPTE2 GSK3A HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway PRKACA-1 GNG2 GNG10 GNG5 GNG4 HRH2 ADCY7 GNG8 PRKAR2B PRKAR2A GNB1 GNB2 GNB4 GNB3 GNB5 GNAL PRKX PRKACB-1 ADCY2 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway GNG2 GNG10 GNG5 GNG4 ADCY7 ADRB3 GNG8 GNB1 GNB2 GNB4 GNB3 GNB5 GNAL ADCY2 PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism NT5E GDA AMPD3 XDH METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis MTR-1 CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway GNG2 GNA14 GNG10 GNG5 GNG4 GNA11 GNG8 CRHR1 GNB1 CRHR2 POMC GNB2 CRH GNAQ GNB4 GNB3 GNB5 GNAL ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway MAPK3 APP MAPK10 KAT5 PSENEN CACNB2 MAPK7 ADAM17 PKN3 BACE1 CACNA1D CACNA1F BACE2 KLC1 MAPK6 KLC4 KLC3 KLC2 PKN2 CACNA1S MAPK4 APBA1 PKN1 APBA3 CACNB1 APBA2 MAPK15 PSEN2 MAPK14 PSEN1 MAPK12 MAPK13 MAPK11 NCSTN APH1B CHRNA7;CHRFAM7A CACNA1C PRKCG PRKCI PRKCH PRKCB MAPK9 PRKCE MAPK8 PRKCD PRKCA PRKCQ PRKCZ MAPK1 CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis CBS;CBSL AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo CXCR4 ROBO1 CXCL12 ABL1 SLIT1 SLIT3 SLIT2 NTN1 NTN3 NTNG1 NTNG2 DCC SRGAP1 NTN4 RHOC CDC42 RAC1 DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis NME4-1 NME2 NME3 CPS1 CAD CTPS2 CTPS1 DSCAML1 DHODH NME1 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway PLCG1 MAPK3 BRAF MAP3K5 SHC3 AKT2 MAP3K2 AKT3 MAP3K3 GRAP MAPK10 RASA4;RASA4B GAB1 GAB2 RRAS SOS1 SOS2 RASA1 RASA2 PIK3R5 STAT4 STAT6 STAT5A STAT5B STAT1 STAT2 STAT3 MAP3K4 MAP2K6 MAP2K4 MAPK14 MAPK12 MAPK13 MAPK11 SHC1-1 ERBB4 PEBP1 PEBP4 RRAS2 ARAF GAB3 MRAS PIK3CD PHLDB2 PIK3CB RASAL2 PIK3C2A EGFR ERBB3 PIK3CG ERBB2 PIK3C2B SPRY4 DAB2IP SPRY3 NF1 SPRY2 AKT1 SPRY1 RAC1 HRAS PRKCG MAP2K3 PRKCI PRKCH PRKCB MAPK9 PRKCE MAPK8 PRKCD PRKCA PIK3CA MAP2K7 PRKD3 PRKD2 PIK3C3 PRKCQ PRKD1 RAF1 SHC2 PRKCZ NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade FGA SERPINB2 MMP1 MMP3 FGG SERPINE1 SERPINF2 PLAUR PLAT PLG MMP9 MMP13 PLAU FGB PNAT%PANTHER PATHWAY%P05912 PNAT SLC6A3 SNAP25 GNG4 SNAP23 GNG8 GNB2 GNB4 GNB3 KCNK9 SNAP29 EPB41 PRKX PRKACB-1 ADCY2 GNAI1 VAMP8 PRKACA-1 VAMP1 EPB41L1 EPB41L2 VAMP2 FLNA DRD2 VAMP3 DRD4 SLC18A2 GNAI3 STX3 ADCY7 GNAI2 GNAZ PRKAR2B PPP1CA PPP1CC PRKAR2A PPP1R1B DRD1 GNB1 DRD5 KCNK3 HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway SHH SMO STK36 FBXW11 PTCH1 BTRC GLI1 GLI3 CREBBP MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway SLC5A7 GNG10 ADCY10 GNG5 GNG4 GNG8 GNB2 GNB4 GNB3 GNB5 PRKX PRKACB-1 PRKAR1B GNAI1 PRKAR1A PRKACA-1 SLC6A8 GNAI3 GNAI2 PRKAR2B PRKAR2A GNB1 GNAO1 CHRM2 CHRM4 GNAT2 GNAT1 KCNJ5 KCNJ6 KCNJ3 SLC18A3 KCNJ9 N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism GNPDA1 GNPDA2 AMDHD2 NPL GFPT2 GFPT1 TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway MAPK3 ACVRL1 BMP10 BMPR2 MSTN SKIL AMHR2 CITED1 CITED2 TGFBR1-1 BMP15-1 BMP8A;BMP8B SNIP1 JUNB ACVR1 LEFTY2;LEFTY1 FOXH1 TGFBR2 ACVR1B ACVR1C SMAD2;SMAD3 GDF10 SMAD1 GDF11 SMAD4 TGFB2 JUND SMURF2 MAPK10 GDF15 TGFB3 SMURF1 GDF2 BMP8B GDF1 SMAD9 INHBB GDF3 INHBA GDF6 RRAS SMAD6 BMP7 GDF5 INHBC SMAD5 ACVR2B BMP6 ACVR2A INHBE BMP5 SMAD7 GDF7 BMP4 FOSL1 SKI BMP3 GDF9 BMP2 BMP1 GDNF TLL2 CREBBP TLL1 MAP3K7 BMPR1B NODAL BMPR1A DCP1B ATF2 MAPK14 MAPK12 MAPK13 MAPK11 TAB1 EP300 HRAS JUN MAPK9 MAPK8 NRAS MAP3K7CL MAPK1 BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation PROS1 TFPI KNG1 THBD VWF F10 GP1BB F12 F2R GP1BA F2 GP5 ITGA2B F3 GP9 PROCR F7 F8 F9 PROC F13B KLKB1 F2RL3 FGB FGA FGG PLAUR PLAT PLG PLAU PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway NOS3 GNA14 GSK3B GNA11 IRS1 GNB2 GNAQ GNB4 GNB3 PIK3CB GNB5 AKT2 PTGER1 FOXO4 CASP9 AKT3 GNGT1 YWHAZ AKT1 GNAI1 PDPK1 INSR FOXO1-1 GNAI3 RPS6KB1 PIK3CA GNAI2 RPS6KB2 SOS1 SOS2 GNB1 FOXO3 PIK3R5 PIK3R3 PIK3R2 PIK3R1 NRAS GNAT2 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway GRM3 GRM2 CALM3;CALM1 GSK3A CREBBP GNG10 HRH1 GNG5 GNG4 GNG8 CREB3L3 CREB3L4 GNB2 CREB3L1 CREB3L2 EP300 GNGT1 GRM1 CHRM3 PRKACB-1 CHRM1 GRM5 CHRM5 PRKAR1B HTR6 PRKAR1A HTR7 ADORA3 ADORA1 PHKA1 PHKA2 MTNR1A MTNR1B ADRB2 HRH3 CLTCL1 GNAI3 HRH4 ADCY7 PHKB GNAI2 PRKAR2B PYGB PRKAR2A CLTC HTR1E CLTB CREB5 HTR1F CLTA OPRD1 HTR1D PYGM HTR1A ADRA1D HTR1B PYGL ADRA1B ADRA1A HTR4 GYS2 GNAL GYS1 GNRHR ADCY4 SSTR1 OPRM1 SSTR2 ADCY1 ADRA2C ADCY8 SSTR3 ADCY6 ADRA2B ADCY5 SSTR4 KCNJ3 SSTR5 CREB3 ADCY9 CREB1 ADORA2A ADORA2B OPRL1 ADCY3 PHKG1 GSK3B PHKG2 OPRK1 GPR50 HTR5A HTR2B HTR2A RAP1B ADRB1 RAP1A HRH2 ADRB3 GRM4 GRM7 GRM6 GRM8 ADCY2 GNAI1 CREM PRKACA-1 GNG2 DRD2 DRD4 DRD1 GNB1 DRD5 CHRM2 CHRM4 KCNJ5 KCNJ6 KCNJ9 FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway PLCG1 MAPK3 MAP3K6 FRS2 FRS3 FGFR4 FGFR3 FGFR2 FGFR1 MAP3K5 SHC3 AKT2 MAP3K2 AKT3 MAP3K3 GRAP MAPK10 PTPN6 RASA4;RASA4B SOS1 SOS2 RASA1 RASA2 MAP3K4 MAP2K6 MAP2K4 MAPK14 MAPK12 MAPK13 MAPK11 SHC1-1 PEBP1 ARAF PIK3CD PIK3CB PIK3C2A PIK3CG PIK3C2B SPRY4 SPRY3 SPRY2 AKT1 SPRY1 RAC1 HRAS PRKCG MAP2K3 PRKCI PRKCH PRKCB MAPK9 PRKCE MAPK8 PRKCD PRKCA PIK3CA MAP2K7 PIK3C3 PRKCQ RAF1 PRKCZ NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis ASL NAGS ASS1 OTC CPS1 CAD HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction GNG10 GNG5 GNG4 GNG8 GNB2 GNB4 GNB5 CALML3 PDC GRK1 RHO CNGA1 GNGT1 PDE6B CALM3;CALM1 CNGA3 PDE6A RGS9 RCVRN GNG13 CNGB3 CNGB1 GNG2 GNB1 GNAT1 ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis BCAT1 BCAT2 PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease MAPK15 PSMA1 MAPK3 TH SLC6A3 CCNE2 PLD2 MAPK14 MAPK12 SFN YWHAZ MAPK10 YWHAE PRKN YWHAB PPP1R8;STX12 MAPK9 PSMA7 MAPK8 PSMB10 PSMA8 PSMB7 YWHAQ PSMB3 CCNE1 PSMB1 NDUFV2 YWHAG YWHAH MAPK7 SNCA GPR37 SEPTIN1 SEPTIN2 STX7 SEPTIN5 ELK1 CASK GPR37L1 SNCAIP SEPTIN4-1 PSMA2-1 PSMA5 PSMA6 MAPK1 PSMA3 PSMA4 MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway ITPR1 ITPR2 SLC5A7 ITPR3 GNA14 GNG10 GNG5 GNG4 GNA11 GNG8 PLCB4 GNB2 GNAQ GNB4 GNB3 GNB5 GRIN2A CHRM3 GRIN2C CHRM1 GRIN2B GRIN2D GRIN1 PRKCG PRKCI GRIN3A PRKCH PRKCB PRKCE PRKCD PRKCA GNB1 PRKCQ PKN3 PKN2 PRKCZ PKN1 SLC18A3 OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway GNAI1 PDYN GNG2 PENK GNG10 GNG5 GNAI3 GNG4 ADCY7 GNAI2 GNG8 GNB1 OPRD1 GNB2 GNB4 GNB3 GNB5 ADCY2 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication RFC5 TOP2A TOP2B RFC3 RFC4 PCNA RFC1 RFC2 PRIM1 RPA2 POLA1 POLD1 POLD2 TOP1 DNA2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway MCEE PCCA PCCB MMUT DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis DSCAML1 NME1 AK1 AK2 GMPS AK3 AK5 AK8 ATIC GUK1 PPAT AK4-1 ADSL RRM1 NME5 RRM2B NME6 NME7 IMPDH2 ADSS1 ADSS2 RRM2-1 GART NME4-1 NME2 NME3 VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway F13B RXRA VDR RARA GC HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway SSTR5 ADORA2A ADORA2B OPRL1 OPRK1 GRM3 GRM2 GNG13 DNAJC27 RAP1B RAP1A GRM4 GRM7 GRM6 GRM8 CACNA1E ITPR1 ITPR2 ITPR3 GNA14 GNG10 GNG5 GNG4 GNA11 GNG8 PLCB3 PLCB4 GNB2 GNAQ GNB4 GNB3 PLCB1 PLCB2 GNGT1 GRM1 CHRM3 RHOA CHRM1 GRM5 CHRM5 PRKCG ADORA3 PRKCI ADORA1 PRKCH GNG2 PRKCB PRKCE DRD2 PRKCD DRD4 PRKCA CLTCL1 CLTC CLTB PRKCQ DRD1 GNB1 CLTA BDKRB2 OPRD1 DRD5 BDKRB1 GARNL3 ARHGEF1 GPR45 GNAO1 RASGRP2 RASGRP1 RASGRP4 GNRHR RAP1GAP CHRM2 SSTR1 CACNA1B RASGRP3 CHRM4 OPRM1 CACNA1A PRKCZ SSTR2 SSTR3 SSTR4 ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis DOK2 DOK3 EPHA3 PLD1 GRB7 PLD2 TCF7 EFNB2 EFNB1 PDGFD PDGFC JAG2 JAG1 APC2 PLA2G4D PDGFRB AXIN1 PDGFRA BIRC5 GRB14-1 DLL1 DLL3 DLL4 PDGFB ANGPT1 PDGFA DLK1 APC TEK GRAP NCK2 JAK1 NCK1 RASA1 HSPB1 CTNNB1 MAP2K4 MAPK14 MAPKAPK3 F2R MAPKAPK2 PRR5 TGFB1I1 ARAF ARHGAP1 PIK3CD PIK3CB PIK3C2A ETS1 PIK3CG PIK3C2B CASP9 ARHGAP8;PRR5-ARHGAP8 KDR AKT1 HRAS PRKCG PRKCI PRKCH JUN PRKCB SPHK2 SPHK1 PRKCE MAPK8 PRKCD PLA2G4A PRKCA PIK3CA PRKD3 PRKD2 PIK3C3 PRKCQ PRKD1 RAF1 CRYAA;CRYAA2 CRYAB SHC2 PXN PIK3R3 PIK3R2 PIK3R1 HIF1A PRKCZ NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 LPXN PLCG1 MAPK3 NOS3 BRAF PTK2 VEGFA GSK3B FRS2 FRS3 CRKL FGFR1 AKT2 AKT3 PAK1 PAK3 PAK2 WNT2B RBPJ FOS WNT5B SOS1 WNT5A SOS2 RBPJL NOTCH2 STAT1 NOTCH1 NOTCH4 STAT3 SHC1-1 DVL1 DVL2 DVL3 WNT1 WNT2 FZD1 TCF7L2 WNT10B RHOC WNT10A FZD3 RHOA FZD2 RHOB FZD5 WNT7B WNT7A CRK MAP3K1 SRC FGF1 JMJD7-PLA2G4B;PLA2G4B EPHB2 EPHB1 EPHB3 DOK1 DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis RRM1 RRM2B NME4-1 NME2 NME3 DTYMK DUT ADAT2 RRM2-1 TYMS DSCAML1 NME1 SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking LOC102724488;SYT15 STX1A STXBP1 SYT7 UNC13D VAMP1 SYT6 RIMS1 SYT12 SNAP25 SYT11 STX2 SYT5 UNC13B UNC13C SYT3 SYT2 RAB3A SYT1 GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 ARRB2 BCAR1 EGR1 PPP3CA LYN CALM3;CALM1 NFKBIA MAPK10 GRB2 JAK2 CLU IER3 RPS6KB1 RPS6 RHEB PTGS2-2 CETP EIF4EBP1 ARHGEF28 MAP2K5 YES1 SP1 SP3 SNAI1 TCF4 MAP3K11 SRF RYR1 HSPB1 ELK1 RYR2 ELAVL1 RYR3 CD38 CTNNB1 GAST NOS1 CCKBR EIF4E AKT1S1 MEF2D PPARG HBEGF MAP2K6 GUCY2D MAP2K4 ITPR1 NR2C2 MEF2C AKAP1 HDAC7 BAD MAPK14 MEF2B;BORCS8-MEF2B PTPN11 CCK TPCN2 TPCN1 CAMK4 TRAF6 ARAF PIK3CB PRKACB-1 AKT1 RAC1 PRKCH JUN PRKCB MAPK9 PRKCE MAPK8 PRKCD BCL2 PLA2G4A PRKCA PRKD2 PRKCQ PRKD1 RAF1 PXN NFATC2 PIK3R1 ADCY1 MAP2K2;MAP2K1 MAPK1 PRKG1 PLCG1 MAPK3 CREB1 BRAF PTK2 GSK3B CXCL8 IRS1 ELK4 RPS6KA3 ODC1 ROCK1 RPS6KA1 PAK1 CDH1 PDPK1 YWHAB FOS FOXO1-1 SOS1 FOXO3 MAPK7 ITGB1 STAT3 ATF2 SHC1-1 CASP3 ITGAV RHOA CREM PRKACA-1 MMP3 GNG2 SLC18A2 PLAU CRK GNB1 SRC BAX MAP3K14 CDC42 BCL2L1 PTK2B GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis GPI HKDC1 HK2 HK1 TPI1 PKLR PGAM2 BPGM ENO1 ENO2 PFKL GAPDH-1 ALDOA PKM PGK1 PFKM NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway JAG2 JAG1 DLL3 DLL4 DLK1 MAML1 NCOR2 NUMB RBPJL CIR1 NOTCH2 NOTCH3 NOTCH1 NOTCH4 RBPJ GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis ABAT ALDH5A1 GAD1 GAD2 CSAD FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway MAP2K4 FASLG CASP7 CASP8 CASP10 CASP3 DAXX MAP3K5 APAF1 CASP9 MAPK10 FAF1 CAPG LMNB2 LMNB1 SCIN CASP6 JUN LMNA DFFB MAPK9 PARP3 MAPK8 GSN PARP4 PARP1 FADD PARP2 CFLAR FAS INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway JUNB VAV1 GRAP JUND JAK2 KRAS ITPR1 ITPR2 ITPR3 MYH1 MYH3 GNA14 GNG10 MYO3B VWF MYO3A MYH8 GNG5 PLCZ1 MYH9 MYH6 GNG4 MYH7 GNA11 GNG8 PLCE1 PLCL1 PLCB3 PLCB4 ARAF GNAQ GNB3 PIK3CD MYH13 PIK3CB MYH14 PLCB1 PLCB2 MYH11 PIK3CG PLCD4 MYH10 PLCD1 MYH7B PRKX PRKACB-1 AKT1 RAC1 JUN PRKCB PRKCE GNAI3 PIK3CA PREX1 GNAI2 CCRL2 PF4;PF4V1-1 LTB4R2 CCL3L1;CCL3L3;CCL3;CCL18 RAF1 IFNAR1 CCL13;CCL2 C5AR1 FPR1 NFATC3 GNAO1 CCR10 NFATC2 CCR1 XCR1 NFATC1 NFATC4 CXCL10 PRKCZ CX3CL1 CCR9 NRAS CCR8 PLCG2 CCR7 ADCY6 CCR6 ADCY5 MAPK1 CCR5 PLCG1 CCR4 CCR3 MAPK3 CCR2 RHOG CX3CR1 NFAT5 CAMK2D CCL11 CAMK2A MYLK2 CXCL8 CXCR5 BUB1B-PAK6;PAK6 CXCR6 CCL4L2;CCL4L1;CCL4 CCL8 MYLK3 CCL5 COL12A1 MYLK CXCR3 CCL22 ARPC5L CCL21 IKBKB CCL20 CCL27 CCL26 AKT2 ROCK1 AKT3 PAK1 PAK3 ACTC1;ACTG2 PAK2 PAK5 PAK4 ACTG1 ARPC4 CHUK PDPK1 RRAS SOS1 IFNG ARPC5 CXCR1 ARPC2 ACTA2 CXCR2 ARPC3 ACTA1 CASK ACTBL2 COL20A1 ITGB1 STAT3 CXCR4 IL2 COL14A1 ARPC1B ARPC1A SHC1-1 ITGAL ITGB7 RHOC RHOA ADCY2 GNAI1 PRKACA-1 GNG2 COL6A2 RELA COL6A1 RELB COL6A3 ACTB-1 NFKB2 CDC42 PTK2B XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway HPRT1 PNP-1 PRTFDC1 GDA HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease RHOG GRIK5 GRIK3 GRIK4 ARPC5L GRIK1 GRIK2 TUBB1 TUBB2B;TUBB2A TUBB3;TUBB6 CYFIP2 GRIN2A CYFIP1 HIP1 AP2A1 AP2A2 ACTC1;ACTG2 CAPN9 CAPNS1 GRIN2C CAPN6 GRIN2B CAPN7 GRIN2D ACTG1 CAPNS2 GRIN1 CAPN5 TUBB4B CAPN2 GRIN3A CAPN3 CAPN1 TUBB4A;TUBB;TUBB8B;TUBB8 IFT57 DYNC2H1 DNAI2 ACTR2 FOS DYNC1LI1 DYNC1LI2 RHOJ GAPDHS HAP1 RHOQ DNAH3 DYNC1I2 ARPC5 DNAH7 DCTN1 SP1 DNAH8 ACTA2 DNAH5 TP63 HTT ACTA1 KALRN CYC1 ACTBL2 DYNC1I1 DYNC1H1 BDNF HIP1R CAPN11 CAPN12 TP53 CAPN10 CREBBP DLG4 TP73 DNAL4 MAP2K4 ARPC1B ARPC1A CASP8 CASP3 MAP3K10 GAPDH-1 APAF1 EP300 TBP RAC1 JUN MAPK9 MAP2K7 ACTB-1 TAF4 CLTB CDC42 ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation ALLC PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism ACLY PC PKM ME1 PCK1 CLYBL CS PKLR PDHA1 T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation PLCG1 MAPK3 BRAF PPP3CA GRAP2 PPP3CB VAV3 IKBKB VAV1 VAV2 AKT2 AKT3 PAK1 PAK3 CALM3;CALM1 PAK2 NFKBIA PTPRC CHUK NCK2 NCK1 FOS SOS1 SOS2 ITPR1 CD86 CD80 CD3G CD3E CD3D PPP3CC ZAP70 LCK LCP2 CD28 CD247 LAT ARAF PIK3CD PIK3CB PIK3CG AKT1 RAC1 HRAS JUN MAPK9 MAPK8 PIK3CA PIK3C3 MAP3K1 PRKCQ RAF1 PIK3R3 PIK3R2 PIK3R1 CDC42 NRAS MAP2K2;MAP2K1 MAPK1 TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway MAPK3 MAPK14 TRAF6 TAB1 IKBKB ECSIT TANK TBK1 IRAK1 MAP3K8 IKBKE TICAM2 IRAK4 TICAM1 TIRAP NFKBIA IRF3 TOLLIP TLR9 TLR8 TLR7 TLR10 MAP2K3 CHUK TLR6 JUN NFKBIE TLR4 TLR3 MAPK9 MYD88 MAPK8 TLR2 ELK1 MAP2K2;MAP2K1 MAP3K7 VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism PDXK PSAT1 PNPO WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway TBL1Y CTNNA3 CTNNA2 CSNK1A1 TLE4 CSNK1G3 TLE3 TLE2 TLE1 CHD1L TLE6 PYGO1 PYGO2 TBL1XR1 CSNK1G2 EP400 BCL9 PPP2R5E DACT1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C ARID1A SMAD1 SAG SMARCD1 SMAD4 SMARCD2 HDAC2 SMARCD3 HDAC3 HDAC8 CTNNAL1 SMARCE1 SMAD5 PPP2CB;PPP2CA SIAH1 CTNNB1 ITPR1 ITPR2 ITPR3 GNA14 GNG10 GNG5 GNG4 GNA11 GNG8 PLCB3 PLCB4 GNB2 GNAQ GNB4 GNB3 PLCB1 PLCB2 NFATC3 NFATC2 NFATC4 WNT2B FZD10 GNG13 CDH3 CDH1 WNT5B WNT5A WNT9B WNT9A WNT16 LEF1 LRP5 WNT8A WNT8B FSTL1 LRP6 WNT6 WNT11 DVL1 DVL2 DVL3 WNT1 WNT2 WNT3 WNT4 FZD1 TCF7L2 WNT10B TCF7L1 WNT10A FZD3 FZD2 FZD5 WNT3A FZD4 WNT7B FZD7 FZD6 FZD9 FZD8 WNT7A ARRB1 ARRB2 PPP3CA PPP3CB AXIN1 HDAC1 PCDHB9;PCDHB10 CELSR1 CDH9 CELSR2 CDH8 CELSR3 CDH7 CREBBP CDH6 CDH5 CDH4 CDH2 PCDHGC4;PCDHGC3 PCDHAC1 PCDHA13 PCDHA11 PCDHA10 PCDHB4-1 PCDH10 PCDH15 PCDH12 PCDH19 PCDH18 PCDHA1 CDH20 CDH22 PCDHA5 CDH23 PCDHA4 CDH24 PCDHA3 PCDHGB5;PCDHGB4 PCDH11X;PCDH11Y PCDH20 PCDHGA10 EP300 PCDHGA11 PCDHGA12 PCDHB2 PCDHB1 PCDHB11;PCDHB12 PCDHB6 FAT1 PRKCG FAT2 PRKCI DCHS1 PRKCH FAT3 PRKCB PCDHB3 PCDHB7 PCDHGB7 PRKCE PCDHGB6 PRKCD PCDHGB2 PCDHA8;PCDHA6-1 PRKCA PCDHGA8 PCDHGA7 PCDHGA5 PCDHGA3 PCDHA7;PCDHA9 PRKCQ PCDHGA2 PCDHGA1 CDHR1 CDH10 CDH11 CDHR2 CDH12 PCDHGB1 CDH13 NFATC1 CDH15 CDH16 PRKCZ CDH17 CDH18 CDH19 PCDHB13;PCDHB8 PCDH1 PCDH9 PCDH7 PCDH8 PCDHB15 PCDHB14 PCDHB5-1 PCDHB16 GSK3B PPP3CC GNG2 SMARCAL1 SMARCB1 ARR3 SMARCC1 SMARCC2 CSNK2A2 CSNK2B GNB1 SRCAP NLK PPP3R1 HLTF SIAH2 FBXW11 SMARCA5 TPTEP2-CSNK1E;CSNK1E BTRC CSNK1D INO80 SMARCA1 SMARCA2 SMARCA4 ANKRD6 HELLS KREMEN1 KREMEN2 CSNK2A1;CSNK2A3 CTNNA1 ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway ADA APRT HPRT1 PNP-1 PRTFDC1 XDH TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism LIPE LIPC METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway STX1A CACNA1E GNG10 SNAP25 ADCY10 GNG5 GNG4 SNAP23 GNG8 GNB2 GNB4 GNB3 GRM3 GNB5 GRM2 SNAP29 PRKX PRKACB-1 PRKAR1B GNAI1 PRKAR1A VAMP8 PRKACA-1 VAMP1 VAMP2 VAMP3 GNAI3 GNAI2 PRKAR2B PRKAR2A GNB1 GNAO1 CACNA1B CACNA1A GNAT2 CACNB1 UNTITLED%PANTHER PATHWAY%P05916 untitled GNAI1 PDYN GNG2 GNG10 OPRK1 GNG5 GNAI3 GNG4 ADCY7 GNAI2 GNG8 GNB1 GNB2 GNB4 GNAO1 GNB3 GNB5 AVP OXT-1 ADCY2 AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins DPYSL5 DPYSL2 DPYS NRP1 SEMA4D SEMA3A CRMP1 CDK5 DPYSL4 FES PLXNA1 PLXNB1 FRK ARHGEF1 PAK1 RHOA FYN RAC1 ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling GNAI1 CACNA1G GNG5 GNAI3 GNG4 GNG8 PLCB3 CNR1 GNB1 GNB2 GNB4 GNAO1 GNB3 PLCB1 PLCB2 CACNA1B CACNA1A GRM1 GRM5 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I TBPL2 TAF8 TBPL1 TTF1 PSMC3IP RRN3 CAVIN1 TAF1B TAF1C POLR1B TAF1A UBTF POLR1D TBP PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway PDXK PNPO SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides TK1 ADAT2 CDA BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway PRKACA-1 GNG2 GNG10 ADRB2 GNG5 GNG4 ADCY7 GNG8 PRKAR2B PRKAR2A GNB1 GNB2 GNB4 GNB3 GNB5 GNAL PRKX PRKACB-1 ADCY2 ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release CREB1 PDYN PENK GNG10 GNG5 GNG4 GNG8 GNB2 GNB4 GNB3 GNB5 PRKX PRKACB-1 ADCY2 GNAI1 CREM PRKACA-1 GNG2 GNAI3 ADCY7 GNAI2 PRKAR2B PRKAR2A GNB1 OPRD1 GNAO1 GNAL OPRM1 ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis ASNS ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway PRKCG ITPR1 PRKCE PRKCD PRKCA GNA11 PLCE1 PLCB3 PLCB4 ADRA1B ADRA1A PLCB1 PLCB2 ADRA2A ADRA2C ADRA2B LOVASTATIN ACTION PATHWAY%SMPDB%SMP0000099 Lovastatin Action Pathway ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA LSS KANAMYCIN ACTION PATHWAY%SMPDB%SMP0000255 Kanamycin Action Pathway SEGAWA SYNDROME%PATHWHIZ%PW000466 Segawa Syndrome CBR1-1 PTS GCHFR QDPR SPR GCH1 AKR1B1 DHFR2;DHFR TEMOCAPRIL ACTION PATHWAY%PATHWHIZ%PW000710 Temocapril Action Pathway ACE REN AGT ALPRENOLOL ACTION PATHWAY%SMPDB%SMP0000297 Alprenolol Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B VATALANIB ACTION PATHWAY%SMPDB%SMP0000421 Vatalanib Action Pathway KDR THE ONCOGENIC ACTION OF FUMARATE%PATHWHIZ%PW002363 The Oncogenic Action of Fumarate FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A EGLN1 EGLN3 EGLN2 PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 SLC25A10 ACO1 SUCLG1 ACO2 DLD ISRADIPINE ACTION PATHWAY%PATHWHIZ%PW000393 Isradipine Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B METHYLMALONIC ACIDURIA DUE TO COBALAMIN-RELATED DISORDERS%PATHWHIZ%PW000208 Methylmalonic Aciduria Due to Cobalamin-Related Disorders ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT ACADM MLYCD ACSS1 HIBCH LDHAL6B DLD BCKDHA ACSS3 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway THIOGUANINE METABOLISM PATHWAY%PATHWHIZ%PW000623 Thioguanine Metabolism Pathway HPRT1 PREDNISOLONE ACTION PATHWAY%SMPDB%SMP0000441 Prednisolone Action Pathway HSP90AA1 NR3C1 CONGENITAL DISORDER OF GLYCOSYLATION CDG-IID%PATHWHIZ%PW000555 Congenital Disorder of Glycosylation CDG-IId SLC35A2 B4GALT1 GALT UGP2 CANT1 CMPK1 SLC2A1 NME2 LALBA G6PC1 CD40L SIGNALLING PATHWAY%SMPDB%SMP0089759 CD40L Signalling Pathway ELP1 TNFAIP3 MAPK14 NFKB1 NFKBIA IKBKB CD40LG TRAF3 TRAF6 IKBKG CD40 MAP3K1 CHUK DUSP1 INOSITOL METABOLISM%SMPDB%SMP0087396 Inositol Metabolism TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120804 Transaldolase Deficiency CAPTOPRIL ACTION PATHWAY%SMPDB%SMP0000146 Captopril Action Pathway ACE REN AGT STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088271 Starch and Sucrose Metabolism LEUKOTRIENE C4 SYNTHESIS DEFICIENCY%PATHWHIZ%PW000118 Leukotriene C4 Synthesis Deficiency PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PYRUVATE DECARBOXYLASE E1 COMPONENT DEFICIENCY (PDHE1 DEFICIENCY)%SMPDB%SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD CARNITINE PALMITOYL TRANSFERASE DEFICIENCY II%PATHWHIZ%PW000517 Carnitine Palmitoyl Transferase Deficiency II ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%SMPDB%SMP0000177 Cystathionine beta-Synthase Deficiency IL4I1 BHMT MTAP MAT2A CBS;CBSL CHDH CTH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B SRM MEPYRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057583 Mepyramine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 CYCLOPHOSPHAMIDE ACTION PATHWAY%PATHWHIZ%PW000248 Cyclophosphamide Action Pathway ALDH3A1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 GSTM1;GSTM2-1 LORATADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061144 Loratadine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 THE ONCOGENIC ACTION OF D-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%SMPDB%SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB GLS2 CS D2HGDH PC GLUD1;GLUD2 SUCLG2 L2HGDH ACO1 SUCLG1 ACO2 DLD GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW121872 Glycogen Synthetase Deficiency T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0120959 T Cell Receptor Signaling Pathway PENBUTOLOL ACTION PATHWAY%SMPDB%SMP0000305 Penbutolol Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B MIRTAZAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062885 Mirtazapine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 DOXORUBICIN METABOLISM PATHWAY%SMPDB%SMP0000650 Doxorubicin Metabolism Pathway AKR1A1 POR NDUFS7 SLC22A16 NDUFS3 NDUFS2 XDH CBR3 ABCG2 CBR1-1 NQO1 ABCC1 ABCC2 ABCB1 NOS3 RALBP1-1 CHOLESTERYL ESTER STORAGE DISEASE%SMPDB%SMP0000508 Cholesteryl Ester Storage Disease ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA LSS GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW122097 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis RUPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060235 Rupatadine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 AMMONIA RECYCLING%PATHWHIZ%PW000009 Ammonia Recycling GLUL ASRGL1 GLS2 GLUD1;GLUD2 HAL SDS CPS1 GLDC AQP8 DLD AMT ASNS TYROSINEMIA, TRANSIENT, OF THE NEWBORN%PATHWHIZ%PW000470 Tyrosinemia, Transient, of the Newborn DCT ALDH3A1 PNMT GOT1-1 ADH1C;ADH1B;ADH1A DDC AOC1 HGD MAOA HAAO MIF DBH TYR COMT FAH GSTZ1 HOMOCHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063751 Homochlorcyclizine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 CHLORTHALIDONE ACTION PATHWAY%SMPDB%SMP0000122 Chlorthalidone Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%SMPDB%SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages MAPK3 CACNA1C NFKB1 NFKBIA PRKCB ITPR1 PLCB1 CACNA1D PRKCA CACNA1F RELA MAP2K2;MAP2K1 MAPK1 CACNA1S RAF1 HRAS CARTEOLOL ACTION PATHWAY%PATHWHIZ%PW000634 Carteolol Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B NATEGLINIDE ACTION PATHWAY%SMPDB%SMP0000453 Nateglinide Action Pathway ABCC8 INS;INS-IGF2 CACNA1A SLC2A2 CACNA2D2 CACNB1 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%SMPDB%SMP0108012 Activation of PKC Through G Protein-Coupled Receptor PHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056662 Pheniramine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 AMINO SUGAR METABOLISM%PATHWHIZ%PW000008 Amino Sugar Metabolism CMAS GFPT1 HEXA UAP1 NPL RENBP HK1 CHIT1 NANP NAGK GNPDA1 AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE DOXYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059730 Doxylamine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463 Phosphatidylinositol Phosphate Metabolism PIKFYVE SYNJ1 INPP5D ERBB2 INPP5E PI4KA PIP5K1A PIP4K2A PIK3C3 CDIPT PLCB1 VAC14 BECN1 PTEN PIK3R4 PIK3CD PIK3R1 AMBRA1 PIK3C2A EGFR FIG4 INPP4B PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0120843 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000494 Glucose-6-phosphate Dehydrogenase Deficiency GPI G6PD TALDO1 PGD DERA RPIA PFKL RPE;RPEL1 PGLS ALDOA TKT FBP1 PGM1 RBKS SPERMIDINE AND SPERMINE BIOSYNTHESIS%PATHWHIZ%PW000037 Spermidine and Spermine Biosynthesis MAT2A ODC1 SMS AMD1 MAT2B SRM ANGIOTENSIN METABOLISM%SMPDB%SMP0000587 Angiotensin Metabolism ACE REN AGT MITOCHONDRIAL COMPLEX II DEFICIENCY%PATHWHIZ%PW000524 Mitochondrial Complex II Deficiency FH MDH1 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD PYRUVALDEHYDE DEGRADATION%SMPDB%SMP0000459 Pyruvaldehyde Degradation GLO1 LDHD HAGH FRUCTOSURIA%PATHWHIZ%PW122105 Fructosuria ADENYLOSUCCINATE LYASE DEFICIENCY%SMPDB%SMP0000167 Adenylosuccinate Lyase Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ITPA ADA TOLMETIN ACTION PATHWAY%PATHWHIZ%PW000681 Tolmetin Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES GEMCITABINE ACTION PATHWAY%SMPDB%SMP0000446 Gemcitabine Action Pathway NT5C DCTD RRM2B SLC29A1 SLC28A1 SLC28A3 RRM1 CMPK1 RRM2-1 CTPS1 TYMS DCK NME1 PHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000380 Phenytoin (Antiarrhythmic) Action Pathway PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 EPHX1 CYP1A2 HYOU1 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 CYP2E1 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 NQO1 COMT TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW121883 Triosephosphate Isomerase Deficiency LACTOSE SYNTHESIS%SMPDB%SMP0000444 Lactose Synthesis SLC35A2 B4GALT1 GALT UGP2 CANT1 CMPK1 SLC2A1 NME2 LALBA G6PC1 PYRIMIDINE METABOLISM%PATHWHIZ%PW000160 Pyrimidine Metabolism DCTD NT5C2 RRM2B CDA DUT DPYS NME6 CAD CANT1 AK3 UPB1 TYMP RRM2-1 DHODH UCKL1 ITPA GDA DPYD CTPS1 CMPK2 TYMS TK1 SHORT-CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (SCHAD)%PATHWHIZ%PW000544 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD) ECHS1 ACAA2 ACAT1 ACADL ACADS HADH ACSS3 HSD17B10 TAMOXIFEN METABOLISM PATHWAY%PATHWHIZ%PW000582 Tamoxifen Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 FMO1 FMO3 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ESR1 CYP2B6 PROTEIN SYNTHESIS: GLUTAMINE%SMPDB%SMP0111862 Protein Synthesis: Glutamine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 QARS1 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437 Vincristine Action Pathway ABCC3 CDKN1A TUBB1 ABCC10 TP53 ABCC1 ABCC2 ABCB1 RALBP1-1 PHENYLBUTAZONE ACTION PATHWAY%PATHWHIZ%PW000678 Phenylbutazone Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES VITAMIN A DEFICIENCY%SMPDB%SMP0000336 Vitamin A Deficiency CYP26A1 DHRS9 ALDH1A2 PNPLA4 PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 CYP2A13;CYP2A6;CYP2A7-1 HYOU1 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 ADH1C;ADH1B;ADH1A RETSAT RDH8 RDH12 AWAT1 RDH11 LRAT BCO1 DGAT1 DHRS3 RPE65 DHRS4 BAMIPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062882 Bamipine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 HYPERPROLINEMIA TYPE I%SMPDB%SMP0000361 Hyperprolinemia Type I GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 OXYTETRACYCLINE ACTION PATHWAY%PATHWHIZ%PW000361 Oxytetracycline Action Pathway ALFENTANIL ACTION PATHWAY%PATHWHIZ%PW000419 Alfentanil Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 REFSUM DISEASE%SMPDB%SMP0000451 Refsum Disease ALDH3A2 ABCD2 HACL1 PHYH-4 ABCD1 SLC27A2 MEVALONIC ACIDURIA%SMPDB%SMP0000510 Mevalonic Aciduria ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA LSS TOBRAMYCIN ACTION PATHWAY%PATHWHIZ%PW000688 Tobramycin Action Pathway METHIONINE ADENOSYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000221 Methionine Adenosyltransferase Deficiency IL4I1 BHMT MTAP MAT2A CBS;CBSL CHDH CTH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B SRM FOSINOPRIL ACTION PATHWAY%PATHWHIZ%PW000227 Fosinopril Action Pathway ACE REN AGT DIHYDROPYRIMIDINASE DEFICIENCY%SMPDB%SMP0000178 Dihydropyrimidinase Deficiency DCTD NT5C2 RRM2B CDA DUT DPYS NME6 CAD CANT1 AK3 UPB1 TYMP RRM2-1 DHODH UCKL1 ITPA GDA DPYD CTPS1 CMPK2 TYMS TK1 DILTIAZEM ACTION PATHWAY%SMPDB%SMP0000359 Diltiazem Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B EUMELANIN BIOSYNTHESIS%SMPDB%SMP0121124 Eumelanin Biosynthesis DCT TYR PHENYLALANINE AND TYROSINE METABOLISM%PATHWHIZ%PW000042 Phenylalanine and Tyrosine Metabolism IL4I1 HPD FARSB GOT1-1 HGD PAH TAT FARSA FAH GSTZ1 YARS1 NALTREXONE ACTION PATHWAY%PATHWHIZ%PW000664 Naltrexone Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 HYPERLYSINEMIA II OR SACCHAROPINURIA%PATHWHIZ%PW000504 Hyperlysinemia II or Saccharopinuria ECHS1 DLST ACAT1 DHTKD1 GCDH SLC25A2 AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH DIFLUNISAL ACTION PATHWAY%SMPDB%SMP0000289 Diflunisal Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES BENDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000329 Bendroflumethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0120583 Glucose-6-phosphate Dehydrogenase Deficiency FANCONI-BICKEL SYNDROME%PATHWHIZ%PW122116 Fanconi-Bickel Syndrome FRUCTOSE INTOLERANCE, HEREDITARY%SMPDB%SMP0120876 Fructose Intolerance, Hereditary AICA-RIBOSIDURIA%PATHWHIZ%PW000082 AICA-Ribosiduria GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ITPA ADA OMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000316 Omeprazole Action Pathway CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 GAST PREDNISONE METABOLISM PATHWAY%PATHWHIZ%PW000607 Prednisone Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 RISEDRONATE ACTION PATHWAY%PATHWHIZ%PW000272 Risedronate Action Pathway ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA LSS PERINDOPRIL ACTION PATHWAY%SMPDB%SMP0000152 Perindopril Action Pathway ACE REN AGT INTRACELLULAR SIGNALLING THROUGH FSH RECEPTOR AND FOLLICLE STIMULATING HORMONE%PATHWHIZ%PW000448 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone ADCY2 PRKACB-1 GNGT1 CREB1 FSHR CGA PPP1CA GNAS-1 GNB1 AROMATIC L-AMINOACID DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000090 Aromatic L-Aminoacid Decarboxylase Deficiency PNMT DDC TH GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%SMPDB%SMP0121312 Glycerol Metabolism IV (Glycerophosphoglycerol) PHENYLACETATE METABOLISM%SMPDB%SMP0000126 Phenylacetate Metabolism ACSM1 ACSM2A;ACSM2B GLYAT PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0000560 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) SLC2A2 MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 DEZOCINE ACTION PATHWAY%PATHWHIZ%PW000653 Dezocine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 KIDNEY FUNCTION - DESCENDING LIMB OF THE LOOP OF HENLE%SMPDB%SMP0121009 Kidney Function - Descending Limb of the Loop of Henle AQP1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW002495 Inositol Phosphate Metabolism CARDIOLIPIN BIOSYNTHESIS (BARTH SYNDROME)%SMPDB%SMP0074684 Cardiolipin Biosynthesis (Barth Syndrome) CDS2 PGS1 GPAM PTPMT1 GPD1 AGPAT5-1 CRLS1 GLYCOLYSIS%PATHWHIZ%PW000839 Glycolysis FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW122106 Fructose-1,6-diphosphatase Deficiency TRAMADOL METABOLISM PATHWAY%PATHWHIZ%PW000613 Tramadol Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 SLC22A1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 ABCC2 GLUCOSE TRANSPORTER DEFECT (SGLT2)%SMPDB%SMP0000184 Glucose Transporter Defect (SGLT2) SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CIRCADIAN RHYTHMS%SMPDB%SMP0090831 Circadian Rhythms PER1 NPR1 CRY1 TPTEP2-CSNK1E;CSNK1E CLOCK CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000480 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 METIAMIDE ACTION PATHWAY%PATHWHIZ%PW000712 Metiamide Action Pathway CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 GAST APROTININ ACTION PATHWAY%SMPDB%SMP0000288 Aprotinin Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 BCR SIGNALING PATHWAY%SMPDB%SMP0120964 BCR Signaling Pathway GLYCOGENOSIS, TYPE IB%SMPDB%SMP0000573 Glycogenosis, Type IB SLC2A2 MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 ISOTHIPENDYL H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060659 Isothipendyl H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 EMEDASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061990 Emedastine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 G-PROTEIN SIGNALING THROUGH TUBBY PROTEINS%PATHWHIZ%PW090863 G-Protein Signaling Through Tubby Proteins GNGT1 TUB GNAQ CHRM1 GNB1 PLCB1 PROTEIN SYNTHESIS: GLUTAMIC ACID%PATHWHIZ%PW112922 Protein Synthesis: Glutamic Acid EPRS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 EPROSARTAN ACTION PATHWAY%PATHWHIZ%PW000279 Eprosartan Action Pathway ACE REN AGT GNG2 GNAQ GNB1 AGTR1 PROTEIN SYNTHESIS: PHENYLALANINE%PATHWHIZ%PW112934 Protein Synthesis: Phenylalanine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 FARSA RPL9 RPL6 RPL7 FARSB RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 LISINOPRIL ACTION PATHWAY%PATHWHIZ%PW000228 Lisinopril Action Pathway ACE REN AGT GLYCOGENOSIS, TYPE VII. TARUI DISEASE%PATHWHIZ%PW000507 Glycogenosis, Type VII. Tarui Disease PFKM PKLR SLC2A2 GPI PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 GALM-2 G6PC1 PGK1 ACETAMINOPHEN METABOLISM PATHWAY%PATHWHIZ%PW000616 Acetaminophen Metabolism Pathway GSTP1 GSTT1 ABCC4 ABCC5 SULT2A1-4 PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 CYP1A2 CYP2A13;CYP2A6;CYP2A7-1 HYOU1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ABCC1 CYP2E1 ABCB1 CYP2D6;LOC107987479;LOC107987478-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ABCG2 PHENYLTOLOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059850 Phenyltoloxamine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 THREONINE AND 2-OXOBUTANOATE DEGRADATION%SMPDB%SMP0000452 Threonine and 2-Oxobutanoate Degradation BCKDHB MMUT PCCA PCCB DBT SDS DLD BCKDHA METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%PATHWHIZ%PW000519 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) FTCD ST20-MTHFS;MTHFS SLC46A1 MTFMT ALDH1L1 MTHFD1L MTHFD1 MTHFD2 MTHFR FPGS GGH DHFR2;DHFR CELECOXIB ACTION PATHWAY%SMPDB%SMP0000096 Celecoxib Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S CYP2C9;CYP2C19 ALOX15B PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES CYP2D6;LOC107987479;LOC107987478-1 PTGS2-2 ADH1C;ADH1B;ADH1A CHONDRODYSPLASIA PUNCTATA II, X-LINKED DOMINANT (CDPX2)%SMPDB%SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA LSS PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW101384 Protein Synthesis: Alanine AARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS GLYCINE AND SERINE METABOLISM%SMPDB%SMP0000004 Glycine and Serine Metabolism GLYCTK GCAT GNMT GARS1 GAMT SRR SARS1 PSAT1 CTH SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD ALAS1 SHMT2 FRUCTOSE METABOLISM%PATHWHIZ%PW000913 Fructose Metabolism VINDESINE ACTION PATHWAY%SMPDB%SMP0000438 Vindesine Action Pathway ABCC3 CDKN1A TUBB1 ABCC10 TP53 ABCC1 ABCC2 ABCB1 RALBP1-1 FEXOFENADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060218 Fexofenadine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 CIMETIDINE ACTION PATHWAY%SMPDB%SMP0000232 Cimetidine Action Pathway CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 GAST INDOMETHACIN ACTION PATHWAY%PATHWHIZ%PW000260 Indomethacin Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 PLA2G2A-1 CLINDAMYCIN ACTION PATHWAY%PATHWHIZ%PW000347 Clindamycin Action Pathway BUCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058964 Buclizine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 AZATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059865 Azatadine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 ALKAPTONURIA%PATHWHIZ%PW000180 Alkaptonuria DCT ALDH3A1 PNMT GOT1-1 ADH1C;ADH1B;ADH1A DDC AOC1 HGD MAOA HAAO MIF DBH TYR COMT FAH GSTZ1 MITOCHONDRIAL ELECTRON TRANSPORT CHAIN%SMPDB%SMP0000355 Mitochondrial Electron Transport Chain ATP5PB ATP5MC2 ATP5F1C ATP5F1D CYCS-1 ATP5F1A SDHC ATP5F1B SDHD GPD2 SDHA UQCRC1 SDHB GAPDH-1 SLC25A4 SLC37A4 VITAMIN K METABOLISM%SMPDB%SMP0000464 Vitamin K Metabolism VKORC1 GGCX NQO1 LIDOCAINE (LOCAL ANAESTHETIC) METABOLISM PATHWAY%SMPDB%SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway CYP1A2 SCN10A CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SCN1B 27-HYDROXYLASE DEFICIENCY%PATHWHIZ%PW000697 27-Hydroxylase Deficiency CH25H AMACR ACOX2 SCP2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 BAAT CYP46A1 CYP7B1 CYP8B1 CYP7A1 LIPA CYP39A1 CYP27A1 BIOTIN METABOLISM%SMPDB%SMP0000066 Biotin Metabolism BTD SPCS1 HLCS ACACB CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY%SMPDB%SMP0000002 Carbamoyl Phosphate Synthetase Deficiency ARG1 GOT2-1 ASS1 GPT SLC1A4 SLC25A15 CPS1 SLC1A5 SLC25A12 ASL OTC GLS2 GLUD1;GLUD2 ISOVALERIC ACIDEMIA%PATHWHIZ%PW000500 Isovaleric Acidemia HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS QUINAPRIL ACTION PATHWAY%SMPDB%SMP0000153 Quinapril Action Pathway ACE REN AGT OXAPROZIN ACTION PATHWAY%PATHWHIZ%PW000262 Oxaprozin Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES GALACTOSE METABOLISM%SMPDB%SMP0000043 Galactose Metabolism GAA LCT GLA B4GALT1 GALT UGP2 PGM1 HK1 G6PC1 GALE AKR1B1 GLB1 FELBAMATE METABOLISM PATHWAY%SMPDB%SMP0000633 Felbamate Metabolism Pathway ALDH3A1 ADH1C;ADH1B;ADH1A CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2E1 HYDROMORPHONE ACTION PATHWAY%PATHWHIZ%PW000416 Hydromorphone Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW122619 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088368 Inositol Phosphate Metabolism BUTYRATE METABOLISM%PATHWHIZ%PW000014 Butyrate Metabolism ECHS1 HMGCL ACAT1 ACADS OXCT1-1 ACSM1 HADH CITRIC ACID CYCLE%SMPDB%SMP0000057 Citric Acid Cycle FH MDH1 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD HYPERINSULINISM-HYPERAMMONEMIA SYNDROME%PATHWHIZ%PW000072 Hyperinsulinism-Hyperammonemia Syndrome ABAT GFPT1 PPAT GOT2-1 GPT ALDH4A1 CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS BIVALIRUDIN ACTION PATHWAY%SMPDB%SMP0000277 Bivalirudin Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 DIPHENOXYLATE ACTION PATHWAY%SMPDB%SMP0000675 Diphenoxylate Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CYPROHEPTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059694 Cyproheptadine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%PATHWHIZ%PW121880 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) MEVALONATE PATHWAY%SMPDB%SMP0121055 Mevalonate Pathway SQLE ACAT1 FDPS IDI1 PMVK MVK MVD FDFT1 HMGCS1-1 HMGCR LSS BENZOCAINE ACTION PATHWAY%SMPDB%SMP0000392 Benzocaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOLYSIS I%SMPDB%SMP0002312 Glycolysis I GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW122063 Glucose-6-phosphate Dehydrogenase Deficiency PHOSPHOLIPID BIOSYNTHESIS%SMPDB%SMP0000025 Phospholipid Biosynthesis CDIPT PGS1 JMJD7-PLA2G4B;PLA2G4B CDS1 GPAM DGKA PTPMT1 CHAT GPD1 GDE1 LYPLA1-1 CRLS1 AGPAT1 PLD2 PTDSS2 PTDSS1 PLA2G2D PCYT1A CHKA PISD PLA2G15 PHOSPHO1 PEMT PLPP1 GPD2 FUMARASE DEFICIENCY%SMPDB%SMP0000547 Fumarase Deficiency FH MDH1 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD DISOPYRAMIDE ACTION PATHWAY%SMPDB%SMP0000325 Disopyramide Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B ALTERNATIVE COMPLEMENT PATHWAY%SMPDB%SMP0063815 Alternative Complement Pathway C9 C3-1 CFP C8A CFB CFD C5 C6 C7 NAPROXEN ACTION PATHWAY%SMPDB%SMP0000120 Naproxen Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES FLUOXETINE METABOLISM PATHWAY%SMPDB%SMP0000646 Fluoxetine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC6A4 BETAXOLOL ACTION PATHWAY%SMPDB%SMP0000299 Betaxolol Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SPHINGOLIPID METABOLISM%PATHWHIZ%PW088482 Sphingolipid Metabolism HYPERPHENYLALANINEMIA DUE TO 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE DEFICIENCY (PTPS)%SMPDB%SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) CBR1-1 PTS GCHFR QDPR SPR GCH1 AKR1B1 DHFR2;DHFR CYCLOTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000103 Cyclothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 GLUCONEOGENESIS%PATHWHIZ%PW064594 Gluconeogenesis TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122107 Triosephosphate Isomerase Deficiency DEGRADATION OF SUPEROXIDES%PATHWHIZ%PW000020 Degradation of Superoxides TYRP1 CAT SOD2 SOD3 SOD1 NEBIVOLOL ACTION PATHWAY%SMPDB%SMP0000366 Nebivolol Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B IRINOTECAN ACTION PATHWAY%PATHWHIZ%PW000238 Irinotecan Action Pathway PDIA2 UGT1A1;UGT1A6 PDIA6 ABCG2 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 BCHE ABCC1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC2 TOP1 ABCB1 CES2 CES1 BROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058500 Brompheniramine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 KETOTIFEN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060812 Ketotifen H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 LOSARTAN ACTION PATHWAY%PATHWHIZ%PW000282 Losartan Action Pathway ACE REN AGT GNG2 GNAQ GNB1 AGTR1 CETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059995 Cetirizine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 HEPARIN ACTION PATHWAY%SMPDB%SMP0000274 Heparin Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 SERPINC1 SPIRAPRIL ACTION PATHWAY%SMPDB%SMP0000156 Spirapril Action Pathway ACE REN AGT WARBURG EFFECT%SMPDB%SMP0086930 Warburg Effect PREDNISONE ACTION PATHWAY%SMPDB%SMP0000440 Prednisone Action Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 HARTNUP DISORDER%SMPDB%SMP0000189 Hartnup Disorder SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 ASTEMIZOLE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059897 Astemizole H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439 Vinorelbine Action Pathway ABCC3 CDKN1A TUBB1 ABCC10 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TP53 ABCC1 ABCC2 ABCB1 RALBP1-1 METHDILAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059730 Methdilazine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 GROWTH HORMONE SIGNALING PATHWAY%PATHWHIZ%PW064811 Growth Hormone Signaling Pathway STAT5A MAPK3 STAT5B INS;INS-IGF2 IRS1 INSR SLC2A4 GHR SOCS1 RPS6KA1 GRB2 PTPN6 PLCG1 SOS1 JAK2 SHC1-1 PRKCA MAP2K2;MAP2K1 MAPK1 RAF1 HRAS KIDNEY FUNCTION - COLLECTING DUCT%PATHWHIZ%PW122278 Kidney Function - Collecting Duct ATP1A1 SLC14A2 SLC4A1 SCNN1G ATP1B3-1 AQP2 AQP3 ATP6V1B1 SCNN1D REN SCNN1B SCNN1A FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 ATP1A4 ATP1A3 CA1 ATP1A2 ATORVASTATIN ACTION PATHWAY%SMPDB%SMP0000131 Atorvastatin Action Pathway ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA LSS GLYCEROL PHOSPHATE SHUTTLE%SMPDB%SMP0000124 Glycerol Phosphate Shuttle GPD2 GAPDH-1 GPD1 NEPAFENAC ACTION PATHWAY%PATHWHIZ%PW000679 Nepafenac Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES RANITIDINE ACTION PATHWAY%SMPDB%SMP0000230 Ranitidine Action Pathway CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 GAST DOPA-RESPONSIVE DYSTONIA%SMPDB%SMP0000486 DOPA-Responsive Dystonia CBR1-1 PTS GCHFR QDPR SPR GCH1 AKR1B1 DHFR2;DHFR 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000525 2-Ketoglutarate Dehydrogenase Complex Deficiency FH MDH1 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD QUINETHAZONE ACTION PATHWAY%SMPDB%SMP0000091 Quinethazone Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 LEIGH SYNDROME%SMPDB%SMP0000196 Leigh Syndrome ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594 Dasatinib Inhibition of BCR-ABL STAT5A GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 TP53 GAB2 CBL MTOR CRKL RPS6KB1 PIK3R1 MYC SKP2 CRK BCL2L1 INOSITOL METABOLISM%PATHWHIZ%PW064607 Inositol Metabolism XIMELAGATRAN ACTION PATHWAY%SMPDB%SMP0000279 Ximelagatran Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 PROTEIN SYNTHESIS: VALINE%PATHWHIZ%PW120528 Protein Synthesis: Valine VARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709 FAS signaling pathway ( CD95 ) RB1 PRKDC FAF1 FASLG LMNB2 LMNB1 MAPK8 PAK1 CASP7 CASP8 CASP6 CASP10 CASP3 LMNA ARHGDIB FADD SPTAN1 MAP3K7 PAK2 DFFB MAP2K4 DAXX JUN DFFA PARP1 RIPK2 CFLAR PTPN13 FAS MAP3K1 ANTAZOLINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057584 Antazoline H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 CINNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059110 Cinnarizine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 MEBHYDROLIN H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061052 Mebhydrolin H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 PACLITAXEL ACTION PATHWAY%PATHWHIZ%PW000239 Paclitaxel Action Pathway TUBB1 ABCG2 ABCC1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC2 ABCB1 PRIMARY HYPEROXALURIA TYPE I%SMPDB%SMP0000352 Primary Hyperoxaluria Type I PC MPC1 AGXT GPT AARS2 HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY%PATHWHIZ%PW000465 Hyperphenylalaninemia Due to DHPR-Deficiency CBR1-1 PTS GCHFR QDPR SPR GCH1 AKR1B1 DHFR2;DHFR GALACTITOL AND GALACTONATE DEGRADATION%SMPDB%SMP0000840 Galactitol and Galactonate Degradation CALVIN-BENSON CYCLE%PATHWHIZ%PW012957 Calvin-Benson Cycle G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW122231 g-Secretase Mediated ErbB4 Signalling Pathway RAMIPRIL ACTION PATHWAY%SMPDB%SMP0000154 Ramipril Action Pathway ACE REN AGT FONDAPARINUX ACTION PATHWAY%SMPDB%SMP0000273 Fondaparinux Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 SERPINC1 IBUPROFEN ACTION PATHWAY%SMPDB%SMP0000086 Ibuprofen Action Pathway SLC22A6 PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 GPX1 DNAJB11 PTGIS ERP29 CYP2J2-1 PPIB SDF2L1 EPHX2 ALOX15 HSPA5 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 HYOU1 LTC4S CYP2C9;CYP2C19 ALOX15B PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 SLC22A8 KIDNEY FUNCTION- PROXIMAL CONVOLUTED TUBULE%SMPDB%SMP0121001 Kidney Function- Proximal Convoluted Tubule SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 SLC38A4 SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 AQP1 CA1 SLC4A4 SLC9A1 IBANDRONATE ACTION PATHWAY%SMPDB%SMP0000079 Ibandronate Action Pathway ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA LSS ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT)%PATHWHIZ%PW000511 Adenine Phosphoribosyltransferase Deficiency (APRT) GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ITPA ADA EPO SIGNALING PATHWAY%PATHWHIZ%PW070692 EPO Signaling Pathway STAT5A EPO MAPK3 FOS ELK1 EPOR MAPK8 GRB2 PTPN6 PLCG1 SOS1 JAK2 SHC1-1 JUN MAP2K2;MAP2K1 RAF1 HRAS CODEINE METABOLISM PATHWAY%PATHWHIZ%PW000597 Codeine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 OPRM1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 RAMIPRIL METABOLISM PATHWAY%SMPDB%SMP0000597 Ramipril Metabolism Pathway ACE LATREPIRDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062623 Latrepirdine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088265 Pentose Phosphate Pathway HOP PATHWAY IN CARDIAC DEVELOPMENT%SMPDB%SMP0090879 Hop Pathway in Cardiac Development SRF GATA4 NKX2-5 HOPX GLUTATHIONE METABOLISM%SMPDB%SMP0000015 Glutathione Metabolism GSS GSR GCLC CASP7 GGCT GCLM GGT6 GPX1 GSTO2 ANPEP OPLAH GAUCHER DISEASE%PATHWHIZ%PW000201 Gaucher Disease PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC NEU3 UGCG UGT8 ACER1 SGPL1 SPTLC1 ACER3 KDSR DEGS2 B4GALT6 ENPP7 GABA-TRANSAMINASE DEFICIENCY%SMPDB%SMP0000351 GABA-Transaminase Deficiency AOC3 CNDP1 ABAT DPYS GAD1 ALDH6A1 UPB1 ALDH2 DPYD PANCREAS FUNCTION - BETA CELL%PATHWHIZ%PW122285 Pancreas Function - Beta Cell GLP1R CACNA1A RAB3A SLC2A2 ITPR3 CAMKK1 RIMS2 ADCY10 VAMP2 RAPGEF4 GNG2 GNAQ GNB1 PLCB1 ABCC8 CACNA2D2 PRKCA CHRM3 CACNB1 LANSOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000317 Lansoprazole Action Pathway CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 GAST EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 6 AND SEROTONIN%SMPDB%SMP0000312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin PRKACB-1 GNGT1 CREB1 PPP1CA GNAS-1 HTR6 GNB1 METHADONE METABOLISM PATHWAY%SMPDB%SMP0000624 Methadone Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 OPRM1 CYP2C9;CYP2C19 GRIN1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 GRIN3A GRIN2A PENTAZOCINE ACTION PATHWAY%SMPDB%SMP0000686 Pentazocine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 MECLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059891 Meclizine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 SELENOAMINO ACID METABOLISM%PATHWHIZ%PW000007 Selenoamino Acid Metabolism PAPSS1 MAT2A CBS;CBSL CTH AHCY MARS1 SLC39A8 METTL6 MAT2B SCLY GGT1 SEPHS2 GLYCOGENOSIS, TYPE VI. HERS DISEASE%PATHWHIZ%PW000531 Glycogenosis, Type VI. Hers Disease UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GPI MGAM GBE1 PYGL HK2 GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 ETHYLMORPHINE ACTION PATHWAY%SMPDB%SMP0000681 Ethylmorphine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCEROL METABOLISM II%PATHWHIZ%PW122618 Glycerol Metabolism II INTRACELLULAR SIGNALLING THROUGH PGD2 RECEPTOR AND PROSTAGLANDIN D2%SMPDB%SMP0000343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 ADCY2 PRKACB-1 GNGT1 GNAS-1 PTGDR GNB1 DICLOFENAC ACTION PATHWAY%PATHWHIZ%PW000135 Diclofenac Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES MOEXIPRIL METABOLISM PATHWAY%SMPDB%SMP0000595 Moexipril Metabolism Pathway ACE STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW002481 Starch and Sucrose Metabolism PHENYLKETONURIA%PATHWHIZ%PW000119 Phenylketonuria IL4I1 HPD FARSB GOT1-1 HGD PAH TAT FARSA FAH GSTZ1 YARS1 FOSPHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000379 Fosphenytoin (Antiarrhythmic) Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B BUPRENORPHINE ACTION PATHWAY%SMPDB%SMP0000684 Buprenorphine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 LYSOPHOSPHATIDIC ACID LPA4 SIGNALLING%SMPDB%SMP0063756 Lysophosphatidic Acid LPA4 Signalling LPAR4 SRF GNAS-1 GNG2 ROCK1 GNB1 ITPR1 AKT1 ADCY1 PLCB1 NADOLOL ACTION PATHWAY%PATHWHIZ%PW000371 Nadolol Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B ARGATROBAN ACTION PATHWAY%SMPDB%SMP0000276 Argatroban Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 TRAMADOL ACTION ACTION PATHWAY%SMPDB%SMP0000671 Tramadol Action Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 LYSOSOMAL ACID LIPASE DEFICIENCY (WOLMAN DISEASE)%PATHWHIZ%PW000099 Lysosomal Acid Lipase Deficiency (Wolman Disease) ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA LSS SIALURIA OR FRENCH TYPE SIALURIA%SMPDB%SMP0000216 Sialuria or French Type Sialuria CMAS GFPT1 HEXA UAP1 NPL RENBP HK1 CHIT1 NANP NAGK GNPDA1 AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS THIAMINE METABOLISM%SMPDB%SMP0000076 Thiamine Metabolism THTPA TPK1 NTPCR SLC19A2 TERFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061157 Terfenadine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 CONGENITAL LIPOID ADRENAL HYPERPLASIA (CLAH) OR LIPOID CAH%SMPDB%SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY%PATHWHIZ%PW000493 Carnitine-Acylcarnitine Translocase Deficiency PEX13 PEX14 ACSL1 CPT2 ABCD2 ABCD1 CROT SLC25A20 PEX11G CRAT CHLORPHENOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059836 Chlorphenoxamine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NIZATIDINE ACTION PATHWAY%SMPDB%SMP0000233 Nizatidine Action Pathway CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 GAST GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%PATHWHIZ%PW000918 Glycerol Metabolism V (Glycerophosphoserine) FABRY DISEASE%SMPDB%SMP0000525 Fabry Disease PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC NEU3 UGCG UGT8 ACER1 SGPL1 SPTLC1 ACER3 KDSR DEGS2 B4GALT6 ENPP7 17-BETA HYDROXYSTEROID DEHYDROGENASE III DEFICIENCY%SMPDB%SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency SULT2B1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 STS SRD5A1 HSD17B1 HSD17B3 HSD3B1;HSD3B2 AKR1D1 CYP19A1 CYP17A1 ARGININEMIA%PATHWHIZ%PW000183 Argininemia ARG1 GOT2-1 ASS1 GPT SLC1A4 SLC25A15 CPS1 SLC1A5 SLC25A12 ASL OTC GLS2 GLUD1;GLUD2 CANAVAN DISEASE%SMPDB%SMP0000175 Canavan Disease IL4I1 ABAT ASS1 ADSL ASNS ASL ASRGL1 GAD1 CAD DDO DARS1 NARS1 ADSS1 ASPA CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%PATHWHIZ%PW109282 Cadmium Induces DNA Synthesis and Proliferation in Macrophages LEVOBUNOLOL ACTION PATHWAY%SMPDB%SMP0000666 Levobunolol Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B MEXILETINE ACTION PATHWAY%PATHWHIZ%PW000382 Mexiletine Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B STREPTOMYCIN ACTION PATHWAY%SMPDB%SMP0000259 Streptomycin Action Pathway DISULFIRAM ACTION PATHWAY%PATHWHIZ%PW000431 Disulfiram Action Pathway DCT ACSS2 ALDH2 ACSS1 ALDH3A1 PNMT GOT1-1 ADH1C;ADH1B;ADH1A DDC AOC1 CAT HGD MAOA HAAO MIF DBH TYR CYP2E1 COMT ALDH1B1 FAH GSTZ1 GROWTH HORMONE SIGNALING PATHWAY%SMPDB%SMP0120947 Growth Hormone Signaling Pathway 3-HYDROXYISOBUTYRIC ACIDURIA%PATHWHIZ%PW000498 3-Hydroxyisobutyric Aciduria HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS ALANINE METABOLISM%SMPDB%SMP0000055 Alanine Metabolism PC MPC1 AGXT GPT AARS2 MALONYL-COA DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000478 Malonyl-CoA Decarboxylase Deficiency ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT ACADM MLYCD ACSS1 HIBCH LDHAL6B DLD BCKDHA ACSS3 CONGENITAL LACTIC ACIDOSIS%PATHWHIZ%PW000522 Congenital Lactic Acidosis FH MDH1 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE DEFICIENCY%PATHWHIZ%PW000063 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS GALACTOSEMIA III%SMPDB%SMP0000496 Galactosemia III GALT GCK UGP2 PGM1 UGDH GALE UXS1 GALK1 PHOSPHOLIPASE C SIGNALING PATHWAY%SMPDB%SMP0063783 Phospholipase C Signaling Pathway VAV1 PIK3CG PIK3R6 PRKCA PLCG1 AKT1 PLCB1 INDAPAMIDE ACTION PATHWAY%SMPDB%SMP0000110 Indapamide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 NAD+ SIGNALLING AND AGING%SMPDB%SMP0084271 NAD+ Signalling and Aging NMNAT1 NPR1 NAMPT NMNAT3 RORA NMNAT2 CLOCK PPARGC1A SIRT1 NQO1 NADK CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP) OR GUNTHER DISEASE%SMPDB%SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 BLVRA COX10 GUSB ALAS1 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 7 AND SEROTONIN%SMPDB%SMP0000311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin PRKACB-1 GNGT1 CREB1 PPP1CA HTR7 GNAS-1 GNB1 PREDNISOLONE METABOLISM PATHWAY%PATHWHIZ%PW000608 Prednisolone Metabolism Pathway HSP90AA1 NR3C1 UREA CYCLE%PATHWHIZ%PW000162 Urea Cycle ARG1 GOT2-1 ASS1 GPT SLC1A4 SLC25A15 CPS1 SLC1A5 SLC25A12 ASL OTC GLS2 GLUD1;GLUD2 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0000374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease SLC2A2 MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 IBUPROFEN METABOLISM PATHWAY%PATHWHIZ%PW000566 Ibuprofen Metabolism Pathway PTGS2-2 SLC22A6 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 CYP2C9;CYP2C19 PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC22A8 GLYCOLYSIS%SMPDB%SMP0087391 Glycolysis STRIATED MUSCLE CONTRACTION%PATHWHIZ%PW000564 Striated Muscle Contraction SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B IMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000601 Imipramine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP1A2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC6A2 SLC6A4 AMIODARONE ACTION PATHWAY%PATHWHIZ%PW000642 Amiodarone Action Pathway CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B4 ATP1B1 CACNB1 PRKAR1B UQCR11 DLG1 PRKAR1A PRKAR2B KCNQ1 PRKAR2A KCNK1 MCU SLC9A1 ALG10;ALG10B SNTB1 SNTB2 PRKACB-1 GNAS-1 CHLOROPROCAINE ACTION PATHWAY%SMPDB%SMP0000394 Chloroprocaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 IMIPRAMINE ACTION PATHWAY%SMPDB%SMP0000422 Imipramine Action Pathway CYP1A2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 KETOROLAC ACTION PATHWAY%SMPDB%SMP0000098 Ketorolac Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES NICOTINE METABOLISM PATHWAY%PATHWHIZ%PW000604 Nicotine Metabolism Pathway CYP2A13;CYP2A6;CYP2A7-1 FMO3 CYP2B6 AOX1 CHRNA4 CHRNB2 CHRNA3 CARNITINE SYNTHESIS%SMPDB%SMP0000465 Carnitine Synthesis TMLHE SETD7 BBOX1 ALDH9A1 SHMT1 FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY%PATHWHIZ%PW000506 Familial Lipoprotein Lipase Deficiency ALDH3A1 GLYCTK AGPAT1 GPD2 LIPC LPL PLPP2 GPAM PLPP1 GPD1 AKR1B1 ETHYLMALONIC ENCEPHALOPATHY%PATHWHIZ%PW000106 Ethylmalonic Encephalopathy ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS TIAPROFENIC ACID ACTION PATHWAY%PATHWHIZ%PW000682 Tiaprofenic Acid Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES BUMETANIDE ACTION PATHWAY%SMPDB%SMP0000088 Bumetanide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 GLYCEROL METABOLISM%PATHWHIZ%PW000914 Glycerol Metabolism BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692 BCR-ABL Action in CML Pathogenesis STAT5A GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 TP53 GAB2 CBL MTOR CRKL RPS6KB1 PIK3R1 MYC SKP2 CRK BCL2L1 GLUTAMATE METABOLISM%PATHWHIZ%PW000003 Glutamate Metabolism ABAT GFPT1 PPAT GOT2-1 GPT ALDH4A1 CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS XANTHINURIA TYPE I%SMPDB%SMP0000512 Xanthinuria Type I GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ITPA ADA GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0000554 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GPI MGAM GBE1 PYGL HK2 GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 AZATHIOPRINE ACTION PATHWAY%SMPDB%SMP0000427 Azathioprine Action Pathway ABCC4 SLC29A1 ABCC5 SLC28A3 TPMT ADK RAC1 SLC28A2 SLC29A2 AOX1 GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ITPA ADA GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000185 Glutaric Aciduria Type I ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000186 Glutaric Aciduria Type I ECHS1 DLST ACAT1 DHTKD1 GCDH SLC25A2 AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH BETAZOLE ACTION PATHWAY%PATHWHIZ%PW000713 Betazole Action Pathway CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 GAST TENOFOVIR METABOLISM PATHWAY%PATHWHIZ%PW000606 Tenofovir Metabolism Pathway NME2 AK1 AK2 NME1 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 MERCAPTOPURINE ACTION PATHWAY%PATHWHIZ%PW000267 Mercaptopurine Action Pathway ABCC4 SLC29A1 ABCC5 SLC28A3 TPMT ADK RAC1 SLC28A2 SLC29A2 AOX1 GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ITPA ADA CYSTEINE METABOLISM%PATHWHIZ%PW000018 Cysteine Metabolism CDO1 GOT1-1 GCLC CTH LDHA GCLM MPST CTNS CARS1 MEFENAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000261 Mefenamic Acid Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES EGF SIGNALLING PATHWAY%SMPDB%SMP0063810 EGF Signalling Pathway FOS ELK1 SRF GRB2 PLCG1 PRKCB SOS1 SHC1-1 STAT6 JAK1 STAT1 EGF STAT2 STAT3 RASA1 PRKCA CSNK2A1;CSNK2A3 MAP2K2;MAP2K1 RAF1 HRAS MAPK3 MAPK8 MAP2K4 JUN EGFR MAP3K1 FOLATE METABOLISM%SMPDB%SMP0000053 Folate Metabolism FTCD ST20-MTHFS;MTHFS SLC46A1 MTFMT ALDH1L1 MTHFD1L MTHFD1 MTHFD2 MTHFR FPGS GGH DHFR2;DHFR FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087296 Fructose and Mannose Degradation BEPOTASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060058 Bepotastine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 ARBEKACIN ACTION PATHWAY%PATHWHIZ%PW000690 Arbekacin Action Pathway FAMOTIDINE ACTION PATHWAY%SMPDB%SMP0000231 Famotidine Action Pathway CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 GAST MAGNESIUM SALICYLATE ACTION PATHWAY%PATHWHIZ%PW000675 Magnesium Salicylate Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES GAMMA-CYSTATHIONASE DEFICIENCY (CTH)%PATHWHIZ%PW000490 gamma-Cystathionase Deficiency (CTH) CBS;CBSL CTH VITAMIN B6 METABOLISM%PATHWHIZ%PW000053 Vitamin B6 Metabolism AOX1 PDXK PNPO PDXP ALPL NUCLEOTIDE SUGARS METABOLISM%SMPDB%SMP0087384 Nucleotide Sugars Metabolism EMBRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062622 Embramine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 ATENOLOL ACTION PATHWAY%SMPDB%SMP0000298 Atenolol Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B RESCINNAMINE ACTION PATHWAY%SMPDB%SMP0000155 Rescinnamine Action Pathway ACE REN AGT PROPIONIC ACIDEMIA%PATHWHIZ%PW000062 Propionic Acidemia HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS 5-OXOPROLINASE DEFICIENCY%PATHWHIZ%PW000476 5-Oxoprolinase Deficiency GSS GSR GCLC CASP7 GGCT GCLM GGT6 GPX1 GSTO2 ANPEP OPLAH PROTEIN SYNTHESIS: METHIONINE%PATHWHIZ%PW112933 Protein Synthesis: Methionine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 MARS1 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 GLUCONEOGENESIS FROM L-MALIC ACID%SMPDB%SMP0000839 Gluconeogenesis from L-Malic Acid CAPECITABINE METABOLISM PATHWAY%SMPDB%SMP0000607 Capecitabine Metabolism Pathway CDA SLC28A1 TYMP TYMS CES1 DEXBROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058503 Dexbrompheniramine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 RIBOFLAVIN METABOLISM%SMPDB%SMP0000070 Riboflavin Metabolism ACP1 TYR FLAD1 RFK ENPP1 ACETYLSALICYLIC ACID ACTION PATHWAY%PATHWHIZ%PW000128 Acetylsalicylic Acid Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES MORPHINE ACTION PATHWAY%PATHWHIZ%PW000412 Morphine Action Pathway PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 MITOCHONDRIAL BETA-OXIDATION OF SHORT CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000171 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids ECHS1 ACAA2 ACAT1 ACADL ACADS HADH ACSS3 HSD17B10 ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC DEFICIENCY)%SMPDB%SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) ARG1 GOT2-1 ASS1 GPT SLC1A4 SLC25A15 CPS1 SLC1A5 SLC25A12 ASL OTC GLS2 GLUD1;GLUD2 PROPRANOLOL ACTION PATHWAY%SMPDB%SMP0000307 Propranolol Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B FATTY ACID METABOLISM%PATHWHIZ%PW000023 Fatty Acid Metabolism ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS VALINE, LEUCINE, AND ISOLEUCINE DEGRADATION%PATHWHIZ%PW000051 Valine, Leucine, and Isoleucine Degradation HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS 3-METHYLGLUTACONIC ACIDURIA TYPE I%SMPDB%SMP0000139 3-Methylglutaconic Aciduria Type I HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS DIMETINDENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057582 Dimetindene H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 PLASMALOGEN SYNTHESIS%PATHWHIZ%PW000170 Plasmalogen Synthesis AGPAT1 GNPAT AGPS CEPT1 PLPP1 SULFITE OXIDASE DEFICIENCY%PATHWHIZ%PW000508 Sulfite Oxidase Deficiency SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SULT2B1 CHST11 BPNT1 SUOX PAPSS2 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY I%PATHWHIZ%PW000514 Carnitine Palmitoyl Transferase Deficiency I ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS BENAZEPRIL ACTION PATHWAY%SMPDB%SMP0000145 Benazepril Action Pathway ACE REN AGT CIMETIDINE METABOLISM PATHWAY%PATHWHIZ%PW000593 Cimetidine Metabolism Pathway HRH2 CELECOXIB METABOLISM PATHWAY%SMPDB%SMP0000644 Celecoxib Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 PTGS2-2 CYP2C9;CYP2C19 ADH1C;ADH1B;ADH1A CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PTGS1 ADEFOVIR DIPIVOXIL METABOLISM PATHWAY%PATHWHIZ%PW000605 Adefovir Dipivoxil Metabolism Pathway NME2 AK1 AK2 NME1 CHILD SYNDROME%PATHWHIZ%PW000096 CHILD Syndrome ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA LSS TREHALOSE DEGRADATION%PATHWHIZ%PW000169 Trehalose Degradation ATP1A1 SLC2A2 GCK FXYD2;FXYD6-FXYD2 TREH ATP1B2 SLC5A1-1 ATP1B1 ATP1A4 ATP1A3 ATP1A2 ATP1B3-1 PYRUVATE METABOLISM%PATHWHIZ%PW000054 Pyruvate Metabolism ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD HYPERPROLINEMIA TYPE II%SMPDB%SMP0000360 Hyperprolinemia Type II GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 CITALOPRAM METABOLISM PATHWAY%PATHWHIZ%PW000603 Citalopram Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 AOX1 MAOA MAOB SLC6A4 ACETAMINOPHEN ACTION PATHWAY%SMPDB%SMP0000710 Acetaminophen Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES TORSEMIDE ACTION PATHWAY%PATHWHIZ%PW000338 Torsemide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA%SMPDB%SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria ECHS1 DLST ACAT1 DHTKD1 GCDH SLC25A2 AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH FENTANYL ACTION PATHWAY%PATHWHIZ%PW000421 Fentanyl Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLUCOSE-ALANINE CYCLE%SMPDB%SMP0000127 Glucose-Alanine Cycle SLC2A2 SLC2A4 GLUD1;GLUD2 GPT SLC38A4 GPT2 SLC1A4 SLC25A22 GEMCITABINE METABOLISM PATHWAY%PATHWHIZ%PW000579 Gemcitabine Metabolism Pathway NT5C DCTD RRM2B SLC29A1 SLC28A1 SLC28A3 RRM1 CMPK1 RRM2-1 CTPS1 TYMS DCK NME1 WARBURG EFFECT%PATHWHIZ%PW000630 Warburg Effect FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT GPI IDH3A G6PD SLC1A5 TALDO1 PGD PDHA1 IDH3G RPIA IDH1 PFKL PGAM2 ENO1 PGLS SDHC SDHD HK2 SDHA TKT GAPDH-1 SDHB GLS2 CS PC GLUD1;GLUD2 SUCLG2 ACO1 SUCLG1 ACO2 DLD PKLR SLC2A2 MDH1 LDHA SLC16A1 PKM ALDOB PGK1 ENALAPRIL METABOLISM PATHWAY%SMPDB%SMP0000593 Enalapril Metabolism Pathway ACE TAY-SACHS DISEASE%PATHWHIZ%PW000215 Tay-Sachs Disease CMAS GFPT1 HEXA UAP1 NPL RENBP HK1 CHIT1 NANP NAGK GNPDA1 AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596 Bosutinib Inhibition of BCR-ABL STAT5A GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 TP53 GAB2 CBL MTOR CRKL RPS6KB1 PIK3R1 MYC SKP2 CRK BCL2L1 WARBURG EFFECT%SMPDB%SMP0087527 Warburg Effect HYPERMETHIONINEMIA%SMPDB%SMP0000341 Hypermethioninemia IL4I1 BHMT MTAP MAT2A CBS;CBSL CHDH CTH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B SRM G(M2)-GANGLIOSIDOSIS: VARIANT B, TAY-SACHS DISEASE%SMPDB%SMP0000534 G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease CMAS GFPT1 HEXA UAP1 NPL RENBP HK1 CHIT1 NANP NAGK GNPDA1 AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE KANDUTSCH-RUSSELL PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis) DHCR7 LBR NSDHL EBP SC5D CYP51A1 MSMO1 DHCR24 HSD17B7 ARGININE AND PROLINE METABOLISM%SMPDB%SMP0000020 Arginine and Proline Metabolism GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 LYMECYCLINE ACTION PATHWAY%SMPDB%SMP0000295 Lymecycline Action Pathway LEVALLORPHAN ACTION PATHWAY%SMPDB%SMP0000683 Levallorphan Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 FLUVASTATIN ACTION PATHWAY%PATHWHIZ%PW000274 Fluvastatin Action Pathway ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA LSS STAT3 SIGNALING PATHWAY%PATHWHIZ%PW068597 Stat3 Signaling Pathway TYK2 JAK1 STAT3 MTOR MAPK1 IBUTILIDE ACTION PATHWAY%SMPDB%SMP0000332 Ibutilide Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B HEROIN METABOLISM PATHWAY%PATHWHIZ%PW000599 Heroin Metabolism Pathway OPRM1 BCHE CES2 CES1 INOSITOL METABOLISM%PATHWHIZ%PW088478 Inositol Metabolism ADENOSINE DEAMINASE DEFICIENCY%PATHWHIZ%PW000075 Adenosine Deaminase Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ITPA ADA RAS SIGNALING PATHWAY%SMPDB%SMP0063784 Ras Signaling Pathway MAPK3 ELK1 RAC1 CYCS-1 VAV3 BAD SMAD4 APAF1 FOXO4 RALA-1 PLD1 RHOA CASP9 CDC42 MAP2K2;MAP2K1 PIK3CA SMAD2;SMAD3 BCL2L1 CHUK AKT1 RAF1 RALGDS RALBP1-1 HRAS PANTOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000318 Pantoprazole Action Pathway CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 GAST PIRENZEPINE ACTION PATHWAY%SMPDB%SMP0000246 Pirenzepine Action Pathway CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 GAST ORPHENADRINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059735 Orphenadrine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 EBASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061153 Ebastine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 ALDOSTERONE FROM STEROIDOGENESIS%SMPDB%SMP0121126 Aldosterone from Steroidogenesis HSD3B1;HSD3B2 CYP11B1;CYP11B2 CYP11A1 GNG2 CYP21A2 GNAQ GNB1 AGTR1 SPIRONOLACTONE ACTION PATHWAY%SMPDB%SMP0000134 Spironolactone Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0000520 Transaldolase Deficiency GPI G6PD TALDO1 PGD DERA RPIA PFKL RPE;RPEL1 PGLS ALDOA TKT FBP1 PGM1 RBKS CATECHOLAMINE BIOSYNTHESIS%SMPDB%SMP0000012 Catecholamine Biosynthesis PNMT DDC TH ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251 Erlotinib Action Pathway ABCG2 ABCB1 EGFR NIFEDIPINE ACTION PATHWAY%PATHWHIZ%PW000394 Nifedipine Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B BETA-MERCAPTOLACTATE-CYSTEINE DISULFIDURIA%SMPDB%SMP0000499 beta-Mercaptolactate-Cysteine Disulfiduria CDO1 GOT1-1 GCLC CTH LDHA GCLM MPST CTNS CARS1 ETHACRYNIC ACID ACTION PATHWAY%SMPDB%SMP0000097 Ethacrynic Acid Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 GLYCOLYSIS AND PYRUVATE DEHYDROGENASE%SMPDB%SMP0000807 Glycolysis and Pyruvate Dehydrogenase CHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000078 Chlorothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 ABCIXIMAB ACTION PATHWAY%SMPDB%SMP0000265 Abciximab Action Pathway ITGA2B ITGB3 BENAZEPRIL METABOLISM PATHWAY%SMPDB%SMP0000591 Benazepril Metabolism Pathway ACE LEVORPHANOL ACTION PATHWAY%SMPDB%SMP0000673 Levorphanol Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 LYSOPHOSPHATIDIC ACID LPA5 SIGNALLING%SMPDB%SMP0063757 Lysophosphatidic Acid LPA5 Signalling LPAR5 SRF GNAS-1 GNG2 ROCK1 GNB1 ITPR1 AKT1 ADCY1 PLCB1 MEPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000405 Mepivacaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 MELOXICAM ACTION PATHWAY%SMPDB%SMP0000106 Meloxicam Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES METHYCLOTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000327 Methyclothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 IFOSFAMIDE ACTION PATHWAY%PATHWHIZ%PW000249 Ifosfamide Action Pathway BILE ACID DIRECT SIGNALLING PATHWAY (2)%PATHWHIZ%PW090771 Bile Acid Direct Signalling Pathway (2) GLP1R SLC10A2 GPBAR1 NALOXONE ACTION PATHWAY%SMPDB%SMP0000688 Naloxone Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 UROKINASE ACTION PATHWAY%SMPDB%SMP0000284 Urokinase Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 INSULIN SIGNALLING%PATHWHIZ%PW000454 Insulin Signalling PIK3CG INS;INS-IGF2 IRS1 PIK3R6 INSR PDPK1 SLC2A4 FOXO1-1 MAPK8 IRS2 GRB2 SOS1 SHC1-1 MAP2K2;MAP2K1 MAPK1 AKT1 RAF1 HRAS SUPROFEN ACTION PATHWAY%SMPDB%SMP0000101 Suprofen Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES HYDROCHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000100 Hydrochlorothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 PYRUVATE KINASE DEFICIENCY%PATHWHIZ%PW000535 Pyruvate Kinase Deficiency ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD PROTEIN SYNTHESIS: LEUCINE%SMPDB%SMP0111873 Protein Synthesis: Leucine LARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0087496 Inositol Phosphate Metabolism WARFARIN ACTION PATHWAY%SMPDB%SMP0000268 Warfarin Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 GLUCONEOGENESIS FROM L-MALIC ACID%PATHWHIZ%PW002518 Gluconeogenesis from L-Malic Acid TIMOLOL ACTION PATHWAY%PATHWHIZ%PW000636 Timolol Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B ADRENOLEUKODYSTROPHY, X-LINKED%PATHWHIZ%PW000492 Adrenoleukodystrophy, X-Linked PEX13 PEX14 ACSL1 CPT2 ABCD2 ABCD1 CROT SLC25A20 PEX11G CRAT ANTIPYRINE ACTION PATHWAY%SMPDB%SMP0000692 Antipyrine Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES HYDROXYETHYLPROMETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 HYPERCHOLESTEROLEMIA%PATHWHIZ%PW000221 Hypercholesterolemia ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA LSS INOSITOL METABOLISM%SMPDB%SMP0002397 Inositol Metabolism DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DHPD)%SMPDB%SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) GLYCTK GCAT GNMT GARS1 GAMT SRR SARS1 PSAT1 CTH SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD ALAS1 SHMT2 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%PATHWHIZ%PW121901 Glycogenosis, Type IA. Von Gierke Disease TOCAINIDE ACTION PATHWAY%SMPDB%SMP0000330 Tocainide Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B ALTEPLASE ACTION PATHWAY%PATHWHIZ%PW000302 Alteplase Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 TIROFIBAN ACTION PATHWAY%PATHWHIZ%PW000293 Tirofiban Action Pathway ITGA2B ITGB3 GAMMA-GLUTAMYLTRANSPEPTIDASE DEFICIENCY%SMPDB%SMP0000501 gamma-Glutamyltranspeptidase Deficiency GSS GSR GCLC CASP7 GGCT GCLM GGT6 GPX1 GSTO2 ANPEP OPLAH TICLOPIDINE ACTION PATHWAY%SMPDB%SMP0000261 Ticlopidine Action Pathway P2RY12 FAMILIAL HYPERCHOLANEMIA (FHCA)%PATHWHIZ%PW000194 Familial Hypercholanemia (FHCA) CH25H AMACR ACOX2 SCP2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 BAAT CYP46A1 CYP7B1 CYP8B1 CYP7A1 LIPA CYP39A1 CYP27A1 IMINOGLYCINURIA%PATHWHIZ%PW000219 Iminoglycinuria SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 FLURBIPROFEN ACTION PATHWAY%SMPDB%SMP0000697 Flurbiprofen Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES DOPAMINE ACTIVATION OF NEUROLOGICAL REWARD SYSTEM%PATHWHIZ%PW000440 Dopamine Activation of Neurological Reward System ADCY2 PRKACB-1 GNAS-1 DRD1 LAFUTIDINE H2-ANTIHISTAMINE ACTION%PATHWHIZ%PW051946 Lafutidine H2-Antihistamine Action CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 GAST CARBAMAZEPINE METABOLISM PATHWAY%PATHWHIZ%PW000610 Carbamazepine Metabolism Pathway CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 EPHX1 P53 SIGNALING PATHWAY%PATHWHIZ%PW064774 P53 Signaling Pathway PCNA GADD45B CCNB1 CCND1 CCNE1 CDK4 CDK2 BCL2 CDKN1A CDK1 E2F1 BAX APAF1 RB1 METOLAZONE ACTION PATHWAY%SMPDB%SMP0000105 Metolazone Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW122096 Glycogen Synthetase Deficiency OXATOMIDE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059044 Oxatomide H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 COMPLEMENT PATHWAY%PATHWHIZ%PW064819 Complement Pathway CFD C5 C6 C7 C9 C3-1 C8A C1QB CFB C1S C1R C2 MBL2-1 SERPING1 MASP2 LOC110384692;C4A;C4B_2;C4B MASP1 C1QC MIZOLASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060230 Mizolastine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 PHENINDAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062141 Phenindamine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 LYSINURIC PROTEIN INTOLERANCE%SMPDB%SMP0000197 Lysinuric Protein Intolerance SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 UBIQUITIN–PROTEASOME PATHWAY%SMPDB%SMP0063816 Ubiquitin–Proteasome Pathway PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMD4 PSMB2 PSMB3 UBD PSMB1 UBB;UBC UBE2E1 PSMC2-1 PSMA2-1 PSMA5 PSMA6 PSMC5 PSMA3 PSMA4 PSMC6 PSMC3 PSMA1 PSMC4 PSMC1 STUB1 UBA1 D-GLYCERIC ACIDURA%PATHWHIZ%PW000505 D-Glyceric Acidura ALDH3A1 GLYCTK AGPAT1 GPD2 LIPC LPL PLPP2 GPAM PLPP1 GPD1 AKR1B1 GNRH SIGNALING PATHWAY%SMPDB%SMP0120949 GnRH Signaling Pathway CAFFEINE METABOLISM%SMPDB%SMP0000028 Caffeine Metabolism CYP1A2 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 XDH CYP2E1 ANILERIDINE ACTION PATHWAY%SMPDB%SMP0000674 Anileridine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CODEINE ACTION PATHWAY%PATHWHIZ%PW000411 Codeine Action Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 HTR1A OPRM1 CACNA1A UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 HYPERLYSINEMIA I, FAMILIAL%PATHWHIZ%PW000503 Hyperlysinemia I, Familial ECHS1 DLST ACAT1 DHTKD1 GCDH SLC25A2 AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH ADRENAL HYPERPLASIA TYPE 3 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 RETEPLASE ACTION PATHWAY%SMPDB%SMP0000285 Reteplase Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW000702 Fructose Intolerance, Hereditary FCSK FPGT PHPT1 GFUS HK1 TPI1 AKR1B1 ALDOB PFKL ALDOA FBP1 PFKFB1 PMM1 MPI SORD KHK GMPPB GMDS BUPRANOLOL ACTION PATHWAY%SMPDB%SMP0000670 Bupranolol Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B PROPOXYPHENE ACTION PATHWAY%PATHWHIZ%PW000649 Propoxyphene Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOLYSIS%PATHWHIZ%PW088465 Glycolysis BCR SIGNALING PATHWAY%PATHWHIZ%PW070885 BCR Signaling Pathway FOS ELK1 CD79B CD79A PPP3CA PPP3CB PPP3CC GRB2 BLNK RAC1 PLCG1 LYN SYK PRKCB SOS1 NFATC3 NFATC2 SHC1-1 NFATC1 CALM3;CALM1 NFATC4 BTK ORAI1 PRKCA MAP2K2;MAP2K1 RAF1 HRAS MAPK3 VAV1 MAPK8 JUN MAP3K1 LYSOPHOSPHATIDIC ACID LPA1 SIGNALLING%SMPDB%SMP0063746 Lysophosphatidic Acid LPA1 Signalling LPAR1 SRF GNG2 ROCK1 GNB1 ITPR1 AKT1 ADCY1 PLCB1 PROCAINE ACTION PATHWAY%PATHWHIZ%PW000408 Procaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOGENOSIS, TYPE IC%SMPDB%SMP0000574 Glycogenosis, Type IC SLC2A2 MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 OLOPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060740 Olopatadine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 KETONE BODY METABOLISM%PATHWHIZ%PW000028 Ketone Body Metabolism HMGCL BDH1 ACAT1 OXCT1-1 ASPARTATE METABOLISM%SMPDB%SMP0000067 Aspartate Metabolism IL4I1 ABAT ASS1 ADSL ASNS ASL ASRGL1 GAD1 CAD DDO DARS1 NARS1 ADSS1 ASPA LUMIRACOXIB ACTION PATHWAY%SMPDB%SMP0000699 Lumiracoxib Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595 Nilotinib Inhibition of BCR-ABL STAT5A GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 TP53 GAB2 CBL MTOR CRKL RPS6KB1 PIK3R1 MYC SKP2 CRK BCL2L1 STREPTOKINASE ACTION PATHWAY%PATHWHIZ%PW000304 Streptokinase Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 TENIPOSIDE METABOLISM PATHWAY%SMPDB%SMP0000602 Teniposide Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TOP2A MPO PHOSPHATIDYLCHOLINE BIOSYNTHESIS%SMPDB%SMP0014212 Phosphatidylcholine Biosynthesis CEPT1 PCYT1A CHKA PCYT2 PISD PEMT HYPERORNITHINEMIA WITH GYRATE ATROPHY (HOGA)%PATHWHIZ%PW000481 Hyperornithinemia with Gyrate Atrophy (HOGA) GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 INOSITOL METABOLISM%PATHWHIZ%PW088261 Inositol Metabolism APOPTOTIC DNA FRAGMENTATION AND TISSUE HOMEOSTASIS%SMPDB%SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis TOP2A CAD DFFA CASP7 GZMH;GZMB-1 ENDOG HMGB2 CASP3 HMGB1-1 GLYCEROL METABOLISM II%PATHWHIZ%PW000915 Glycerol Metabolism II GLUCONEOGENESIS%SMPDB%SMP0087318 Gluconeogenesis CLEMASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059823 Clemastine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 EPTIFIBATIDE ACTION PATHWAY%PATHWHIZ%PW000292 Eptifibatide Action Pathway ITGA2B ITGB3 CYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059857 Cyclizine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 ACTIVATION OF CAMP-DEPENDENT PROTEIN KINASE, PKA%SMPDB%SMP0063764 Activation of cAMP-dependent protein kinase, PKA PRKACB-1 GNGT1 PRKACA-1 ADCY10 GNAS-1 PRKAR1B PRKAR2B PRKAR1A PRKAR2A GNB1 GLUCONEOGENESIS%PATHWHIZ%PW000152 Gluconeogenesis SLC2A2 MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 ZELLWEGER SYNDROME%PATHWHIZ%PW000195 Zellweger Syndrome CH25H AMACR ACOX2 SCP2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 BAAT CYP46A1 CYP7B1 CYP8B1 CYP7A1 LIPA CYP39A1 CYP27A1 ANISTREPLASE ACTION PATHWAY%PATHWHIZ%PW000303 Anistreplase Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 PROTEIN SYNTHESIS: LYSINE%SMPDB%SMP0111874 Protein Synthesis: Lysine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A KARS1 RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 DICUMAROL ACTION PATHWAY%PATHWHIZ%PW000313 Dicumarol Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088490 Pentose Phosphate Pathway TYROSINEMIA TYPE I%PATHWHIZ%PW000182 Tyrosinemia Type I DCT ALDH3A1 PNMT GOT1-1 ADH1C;ADH1B;ADH1A DDC AOC1 HGD MAOA HAAO MIF DBH TYR COMT FAH GSTZ1 TOLPROPAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062621 Tolpropamine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW000528 Glycogen Synthetase Deficiency UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GPI MGAM GBE1 PYGL HK2 GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%PATHWHIZ%PW121876 Mucopolysaccharidosis VII. Sly Syndrome CLASSICAL COMPLEMENT PATHWAY%PATHWHIZ%PW065057 Classical Complement Pathway C9 C3-1 C8A C1QB C1S C1R C2 LOC110384692;C4A;C4B_2;C4B C5 C1QC C6 C7 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0000581 Glycogenosis, Type IA. Von Gierke Disease SLC2A2 MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 GLYCOLYSIS%PATHWHIZ%PW088241 Glycolysis FRUCTOSE METABOLISM%SMPDB%SMP0012445 Fructose Metabolism CHLOROPYRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058510 Chloropyramine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 PIMETHIXENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062886 Pimethixene H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 ALCAFTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062881 Alcaftadine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 REPAGLINIDE ACTION PATHWAY%SMPDB%SMP0000454 Repaglinide Action Pathway ABCC8 INS;INS-IGF2 CACNA1A SLC2A2 CACNA2D2 CACNB1 STARCH AND SUCROSE METABOLISM%SMPDB%SMP0063673 Starch and Sucrose Metabolism NICOTINATE AND NICOTINAMIDE METABOLISM%PATHWHIZ%PW000151 Nicotinate and Nicotinamide Metabolism BST1 NNT NT5C2 NMRK1 NUDT12 NAMPT NMNAT2 NADK AOX1 PNP-1 NNMT QPRT NADSYN1 ENPP1 SALSALATE ACTION PATHWAY%SMPDB%SMP0000707 Salsalate Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES TELITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000350 Telithromycin Action Pathway TYROSINE METABOLISM%SMPDB%SMP0000006 Tyrosine Metabolism DCT ALDH3A1 PNMT GOT1-1 ADH1C;ADH1B;ADH1A DDC AOC1 HGD MAOA HAAO MIF DBH TYR COMT FAH GSTZ1 ACUTE INTERMITTENT PORPHYRIA%PATHWHIZ%PW000174 Acute Intermittent Porphyria UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 BLVRA COX10 GUSB ALAS1 PORPHYRIA VARIEGATA (PV)%SMPDB%SMP0000346 Porphyria Variegata (PV) UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 BLVRA COX10 GUSB ALAS1 ISOPRENALINE ACTION PATHWAY%SMPDB%SMP0000663 Isoprenaline Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B AMLODIPINE ACTION PATHWAY%PATHWHIZ%PW000391 Amlodipine Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B PIROXICAM ACTION PATHWAY%SMPDB%SMP0000077 Piroxicam Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES CILAZAPRIL METABOLISM PATHWAY%SMPDB%SMP0000592 Cilazapril Metabolism Pathway ACE ACRIVASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060826 Acrivastine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 FRUCTOSE METABOLISM%PATHWHIZ%PW002390 Fructose Metabolism ETOPOSIDE ACTION PATHWAY%SMPDB%SMP0000442 Etoposide Action Pathway PTGS2-2 TOP2B PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 ABCC3 HYOU1 PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TOP2A MPO ABCB1 IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694 Imatinib Inhibition of BCR-ABL STAT5A SLC22A1 GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 TP53 GAB2 CBL MTOR CRKL RPS6KB1 PIK3R1 MYC SKP2 CRK ABCB1 BCL2L1 SALLA DISEASE INFANTILE SIALIC ACID STORAGE DISEASE%SMPDB%SMP0000240 Salla Disease Infantile Sialic Acid Storage Disease CMAS GFPT1 HEXA UAP1 NPL RENBP HK1 CHIT1 NANP NAGK GNPDA1 AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE DIBUCAINE ACTION PATHWAY%SMPDB%SMP0000396 Dibucaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PROLINEMIA TYPE II%PATHWHIZ%PW000087 Prolinemia Type II GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 TRYPTOPHAN METABOLISM%SMPDB%SMP0000063 Tryptophan Metabolism TPH1 ASMT KMO WARS1 INMT ALDH2 WARS2 ACMSD AANAT TDO2 KYNU AFMID CYP1A1 IDO1 AADAT DDC CAT HAAO LPS AND CITRATE SIGNALING AND INFLAMMATION%PATHWHIZ%PW101069 LPS and Citrate Signaling and Inflammation MDH1 NFKB1 ACACA NFKBIA IKBKB TRAF6 IKBKG ME1 SLC25A1 SDHC LY96 SDHD SDHA TIRAP SDHB ACLY CS CD14 TLR4 MYD88 RELA CHUK HYPERGLYCINEMIA, NON-KETOTIC%SMPDB%SMP0000485 Hyperglycinemia, Non-Ketotic GLYCTK GCAT GNMT GARS1 GAMT SRR SARS1 PSAT1 CTH SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD ALAS1 SHMT2 CORTICOSTERONE METHYL OXIDASE I DEFICIENCY (CMO I)%PATHWHIZ%PW000553 Corticosterone Methyl Oxidase I Deficiency (CMO I) HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 STEROID BIOSYNTHESIS%PATHWHIZ%PW000050 Steroid Biosynthesis ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA LSS VASOPRESSIN REGULATION OF WATER HOMEOSTASIS%PATHWHIZ%PW000447 Vasopressin Regulation of Water Homeostasis ADCY2 PRKACB-1 GNGT1 FSHR GNAS-1 AVPR2 GNB1 COAGULATION%SMPDB%SMP0000586 Coagulation VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 ACENOCOUMAROL ACTION PATHWAY%PATHWHIZ%PW000312 Acenocoumarol Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 ETHANOL DEGRADATION%PATHWHIZ%PW000021 Ethanol Degradation ACSS2 ADH1C;ADH1B;ADH1A CAT ALDH2 CYP2E1 ACSS1 ALDH1B1 MINOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000360 Minocycline Action Pathway STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088364 Starch and Sucrose Metabolism GLYCEROL KINASE DEFICIENCY%SMPDB%SMP0000187 Glycerol Kinase Deficiency ALDH3A1 GLYCTK AGPAT1 GPD2 LIPC LPL PLPP2 GPAM PLPP1 GPD1 AKR1B1 PROTEIN SYNTHESIS: GLYCINE%PATHWHIZ%PW112928 Protein Synthesis: Glycine GARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 GALACTOSEMIA%PATHWHIZ%PW000200 Galactosemia GAA LCT GLA B4GALT1 GALT UGP2 PGM1 HK1 G6PC1 GALE AKR1B1 GLB1 BLOCH PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121057 Bloch Pathway (Cholesterol Biosynthesis) DHCR7 LBR NSDHL EBP SC5D CYP51A1 MSMO1 DHCR24 HSD17B7 TYROSINEMIA TYPE 2 (OR RICHNER-HANHART SYNDROME)%SMPDB%SMP0000369 Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) IL4I1 HPD FARSB GOT1-1 HGD PAH TAT FARSA FAH GSTZ1 YARS1 VALDECOXIB ACTION PATHWAY%SMPDB%SMP0000116 Valdecoxib Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES SALICYLATE-SODIUM ACTION PATHWAY%SMPDB%SMP0000708 Salicylate-Sodium Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES DOCETAXEL ACTION PATHWAY%PATHWHIZ%PW000240 Docetaxel Action Pathway TUBB1 ABCG2 ABCC1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC2 ABCB1 SEPIAPTERIN REDUCTASE DEFICIENCY%PATHWHIZ%PW000467 Sepiapterin Reductase Deficiency CBR1-1 PTS GCHFR QDPR SPR GCH1 AKR1B1 DHFR2;DHFR HYPER-IGD SYNDROME%SMPDB%SMP0000509 Hyper-IgD Syndrome ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA LSS TRIPROLIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057581 Triprolidine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 CORTICOSTERONE METHYL OXIDASE II DEFICIENCY (CMO II)%SMPDB%SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II) HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 NAD+ SIGNALLING PATHWAY (CANCER)%PATHWHIZ%PW084315 NAD+ Signalling Pathway (Cancer) NMNAT1 NAMPT TP53 NMNAT3 NMNAT2 SIRT1 NQO1 AIFM2 NADK CD38 OLMESARTAN ACTION PATHWAY%SMPDB%SMP0000163 Olmesartan Action Pathway ACE REN AGT GNG2 GNAQ GNB1 AGTR1 GLUTAMINOLYSIS AND CANCER%SMPDB%SMP0002298 Glutaminolysis and Cancer FH DLST PDHB DHTKD1 MPC1 IDH3B GOT2-1 DLAT IDH3A SLC1A4 SLC1A5 PDHA1 IDH3G IDH2 SLC7A7 SDHC SDHD SDHA SDHB GLS2 CS PC GLUD1;GLUD2 SUCLG2 SUCLG1 ACO2 DLD LDHA ME1 SLC16A1 ACLY SLC38A5 MYCBP-1 PHOTOSYNTHESIS%SMPDB%SMP0012089 Photosynthesis KIDNEY FUNCTION - ASCENDING LIMB OF THE LOOP OF HENLE%PATHWHIZ%PW122277 Kidney Function - Ascending Limb of The Loop of Henle ATP1A1 REN FXYD2;FXYD6-FXYD2 CLCNKA;CLCNKB ATP1B2 ATP1B1 SLC12A6 ATP1A4 ATP1A3 SLC12A1 ATP1A2 ATP1B3-1 FRUCTOSE METABOLISM%PATHWHIZ%PW122616 Fructose Metabolism AMILORIDE ACTION PATHWAY%SMPDB%SMP0000133 Amiloride Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 METHOTREXATE ACTION PATHWAY%SMPDB%SMP0000432 Methotrexate Action Pathway FTCD ST20-MTHFS;MTHFS SLC46A1 MTFMT ALDH1L1 MTHFD1L MTHFD1 MTHFD2 MTHFR FPGS GGH DHFR2;DHFR GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW000529 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GPI MGAM GBE1 PYGL HK2 GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 SALICYLIC ACID ACTION PATHWAY%SMPDB%SMP0000709 Salicylic Acid Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES CITRULLINEMIA TYPE I%PATHWHIZ%PW000185 Citrullinemia Type I ARG1 GOT2-1 ASS1 GPT SLC1A4 SLC25A15 CPS1 SLC1A5 SLC25A12 ASL OTC GLS2 GLUD1;GLUD2 AZELASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060741 Azelastine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 PROMETHAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060150 Promethazine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%SMPDB%SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) IL4I1 BHMT MTAP MAT2A CBS;CBSL CHDH CTH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B SRM RABEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000592 Rabeprazole Metabolism Pathway ATP4B ATP4A DIMETHYLTHIAMBUTENE ACTION PATHWAY%SMPDB%SMP0000680 Dimethylthiambutene Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 RABEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000319 Rabeprazole Action Pathway CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 GAST AMINOCAPROIC ACID ACTION PATHWAY%PATHWHIZ%PW000308 Aminocaproic Acid Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 ETODOLAC ACTION PATHWAY%PATHWHIZ%PW000129 Etodolac Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PROTEIN SYNTHESIS: PROLINE%PATHWHIZ%PW113695 Protein Synthesis: Proline EPRS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 OXYBUPROCAINE ACTION PATHWAY%SMPDB%SMP0000400 Oxybuprocaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 VERAPAMIL ACTION PATHWAY%SMPDB%SMP0000375 Verapamil Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B TYROSINE HYDROXYLASE DEFICIENCY%SMPDB%SMP0000497 Tyrosine Hydroxylase Deficiency PNMT DDC TH SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW122101 Sucrase-Isomaltase Deficiency ORNITHINE AMINOTRANSFERASE DEFICIENCY (OAT DEFICIENCY)%SMPDB%SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency) GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 CXCR4 SIGNALING PATHWAY%SMPDB%SMP0064625 CXCR4 Signaling Pathway PIK3C2G MAPK3 PTK2 GNAI1 NFKB1 GNGT1 CXCL12 NFKBIA PTK2B BCAR1 PLCG1 GNAQ GNB1 MAP2K2;MAP2K1 MAPK1 CRK PXN RAF1 CXCR4 HRAS ARGININE: GLYCINE AMIDINOTRANSFERASE DEFICIENCY (AGAT DEFICIENCY)%PATHWHIZ%PW000084 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 SHORT-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD DEFICIENCY)%PATHWHIZ%PW000108 Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0120839 Mucopolysaccharidosis VII. Sly Syndrome SPIRAPRIL METABOLISM PATHWAY%SMPDB%SMP0000598 Spirapril Metabolism Pathway ACE FORASARTAN ACTION PATHWAY%PATHWHIZ%PW000280 Forasartan Action Pathway ACE REN AGT AGTR1 DICOUMAROL ACTION PATHWAY%PATHWHIZ%PW000632 Dicoumarol Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 CITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000426 Citalopram Action Pathway CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 AOX1 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A MAOB ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 MAOA ATP1B2 ATP1B1 CACNB1 TRIPELENNAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057587 Tripelennamine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 THENYLDIAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062624 Thenyldiamine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 2-HYDROXYGLUTRIC ACIDURIA (D AND L FORM)%SMPDB%SMP0000136 2-Hydroxyglutric Aciduria (D and L Form) ABAT GFPT1 PPAT GOT2-1 GPT ALDH4A1 CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS WOLMAN DISEASE%PATHWHIZ%PW000487 Wolman Disease ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA LSS FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW121913 Fructose Intolerance, Hereditary LIDOCAINE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000381 Lidocaine (Antiarrhythmic) Action Pathway SNTB1 SNTB2 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B OXPRENOLOL ACTION PATHWAY%PATHWHIZ%PW000372 Oxprenolol Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B BLUE DIAPER SYNDROME%SMPDB%SMP0000583 Blue Diaper Syndrome SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE II%PATHWHIZ%PW000192 Congenital Bile Acid Synthesis Defect Type II CH25H AMACR ACOX2 SCP2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 BAAT CYP46A1 CYP7B1 CYP8B1 CYP7A1 LIPA CYP39A1 CYP27A1 CANDESARTAN ACTION PATHWAY%SMPDB%SMP0000158 Candesartan Action Pathway ACE REN AGT GNG2 GNAQ GNB1 AGTR1 LACTIC ACIDEMIA%PATHWHIZ%PW000114 Lactic Acidemia PC MPC1 AGXT GPT AARS2 TNF STRESS RELATED SIGNALING%PATHWHIZ%PW064784 TNF Stress Related Signaling MAPK14 NFKB1 NFKBIA IKBKB MAPK8 MAP2K3 ATF1 MAP4K2 CRADD IKBKG TRADD TRAF2 TANK TNF CASP2 RIPK1 MAP2K7 MAP2K6 MAP2K4 JUN MAP3K1 CHUK TRIAMTERENE ACTION PATHWAY%SMPDB%SMP0000132 Triamterene Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 POLYTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000326 Polythiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 PHYTANIC ACID PEROXISOMAL OXIDATION%PATHWHIZ%PW000041 Phytanic Acid Peroxisomal Oxidation ALDH3A2 ABCD2 HACL1 PHYH-4 ABCD1 SLC27A2 LEPIRUDIN ACTION PATHWAY%SMPDB%SMP0000278 Lepirudin Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 PHOSPHOLIPASE C SIGNALING PATHWAY%PATHWHIZ%PW109280 Phospholipase C Signaling Pathway MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0000556 Mucopolysaccharidosis VII. Sly Syndrome UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GPI MGAM GBE1 PYGL HK2 GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 CYSTINURIA%PATHWHIZ%PW000700 Cystinuria SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 MITOCHONDRIAL BETA-OXIDATION OF LONG CHAIN SATURATED FATTY ACIDS%SMPDB%SMP0000482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids CPT1A ECHS1 HADHB-1 ACAA2 ACSL1 HADHA CPT2 ACADL SLC25A20 HADH INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088427 Inositol Phosphate Metabolism 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000061 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS GLUCONEOGENESIS%PATHWHIZ%PW088242 Gluconeogenesis PYRIDOXINE DEPENDENCY WITH SEIZURES%SMPDB%SMP0000571 Pyridoxine Dependency with Seizures ECHS1 DLST ACAT1 DHTKD1 GCDH SLC25A2 AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH PYRROBUTAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062887 Pyrrobutamine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 OXYCODONE ACTION PATHWAY%SMPDB%SMP0000409 Oxycodone Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DOXYCYCLINE ACTION PATHWAY%PATHWHIZ%PW000359 Doxycycline Action Pathway ACEBUTOLOL ACTION PATHWAY%SMPDB%SMP0000296 Acebutolol Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B CARBINOXAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058797 Carbinoxamine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 AMIKACIN ACTION PATHWAY%SMPDB%SMP0000253 Amikacin Action Pathway NICOTINE ACTION PATHWAY%SMPDB%SMP0000431 Nicotine Action Pathway CYP2A13;CYP2A6;CYP2A7-1 PCSK2 CYP2B6 AOX1 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 FMO3 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CHRNA3 HEREDITARY COPROPORPHYRIA (HCP)%SMPDB%SMP0000342 Hereditary Coproporphyria (HCP) UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 BLVRA COX10 GUSB ALAS1 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease GLOBOID CELL LEUKODYSTROPHY%PATHWHIZ%PW000202 Globoid Cell Leukodystrophy PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC NEU3 UGCG UGT8 ACER1 SGPL1 SPTLC1 ACER3 KDSR DEGS2 B4GALT6 ENPP7 LEVOBUPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000403 Levobupivacaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 HISTIDINE METABOLISM%SMPDB%SMP0000044 Histidine Metabolism CNDP1 HAL ALDH2 FTCD ALDH3A1 HARS1 CARNMT1 HDC PRMT3 AOC1 HNMT HARS2 MAOA CNDP2 UROC1 AMDHD1 CARNS1 PROTEIN SYNTHESIS: ISOLEUCINE%SMPDB%SMP0111872 Protein Synthesis: Isoleucine IARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 MALATE-ASPARTATE SHUTTLE%PATHWHIZ%PW000030 Malate-Aspartate Shuttle SLC25A11 GOT2-1 SLC25A12 MDH2 UMP SYNTHASE DEFICIENCY (OROTIC ACIDURIA)%SMPDB%SMP0000219 UMP Synthase Deficiency (Orotic Aciduria) DCTD NT5C2 RRM2B CDA DUT DPYS NME6 CAD CANT1 AK3 UPB1 TYMP RRM2-1 DHODH UCKL1 ITPA GDA DPYD CTPS1 CMPK2 TYMS TK1 SARCOSINE ONCOMETABOLITE PATHWAY%SMPDB%SMP0002313 Sarcosine Oncometabolite Pathway BHMT GNMT MAT2A CHDH SARDH ALDH7A1 SHMT1 DMGDH SLC44A1 SLC44A2 MAT2B SHMT2 MTR-1 PROCAINAMIDE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000377 Procainamide (Antiarrhythmic) Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B BISOPROLOL ACTION PATHWAY%SMPDB%SMP0000300 Bisoprolol Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B COCAINE ACTION PATHWAY%SMPDB%SMP0000395 Cocaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058785 Diphenhydramine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 LECTIN-INDUCED COMPLEMENT PATHWAY%SMPDB%SMP0063898 Lectin-Induced Complement Pathway C9 C3-1 C8A C2 MBL2-1 MASP2 LOC110384692;C4A;C4B_2;C4B MASP1 C5 C6 C7 FATTY ACID BIOSYNTHESIS%SMPDB%SMP0000456 Fatty Acid Biosynthesis FASN ACACA CAPECITABINE ACTION PATHWAY%PATHWHIZ%PW000256 Capecitabine Action Pathway CDA SLC28A1 TYMP TYMS CES1 L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY%PATHWHIZ%PW000483 L-Arginine:Glycine Amidinotransferase Deficiency GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 PROTEIN SYNTHESIS: ARGININE%SMPDB%SMP0111853 Protein Synthesis: Arginine RARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 BETA-ALANINE METABOLISM%SMPDB%SMP0000007 beta-Alanine Metabolism AOC3 CNDP1 ABAT DPYS GAD1 ALDH6A1 UPB1 ALDH2 DPYD TENIPOSIDE ACTION PATHWAY%SMPDB%SMP0000443 Teniposide Action Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TOP2A MPO TRANSFER OF ACETYL GROUPS INTO MITOCHONDRIA%SMPDB%SMP0000466 Transfer of Acetyl Groups into Mitochondria MDH1 ACLY PDHB PC MPC1 SLC25A11 ME1 PDHA1 CLOPIDOGREL METABOLISM PATHWAY%PATHWHIZ%PW000586 Clopidogrel Metabolism Pathway CYP1A2 CYP2C9;CYP2C19 PON1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 P2RY12 ABCB1 CLOMOCYCLINE ACTION PATHWAY%SMPDB%SMP0000262 Clomocycline Action Pathway GLICLAZIDE ACTION PATHWAY%SMPDB%SMP0000461 Gliclazide Action Pathway ABCC8 INS;INS-IGF2 CACNA1A SLC2A2 CACNA2D2 CACNB1 GLYCEROL METABOLISM%SMPDB%SMP0121309 Glycerol Metabolism 4-HYDROXYBUTYRIC ACIDURIA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000243 4-Hydroxybutyric Aciduria Succinic Semialdehyde Dehydrogenase Deficiency ABAT GFPT1 PPAT GOT2-1 GPT ALDH4A1 CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS ALENDRONATE ACTION PATHWAY%PATHWHIZ%PW000137 Alendronate Action Pathway ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA LSS LABETALOL ACTION PATHWAY%PATHWHIZ%PW000389 Labetalol Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 ADRA1A KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B LONG-CHAIN-3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (LCHAD)%PATHWHIZ%PW000520 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD) ECHS1 HADHB-1 ACAA2 MECR PPT1 HADHA HSD17B10 THONZYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059696 Thonzylamine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 BETA-UREIDOPROPIONASE DEFICIENCY%PATHWHIZ%PW000187 beta-Ureidopropionase Deficiency DCTD NT5C2 RRM2B CDA DUT DPYS NME6 CAD CANT1 AK3 UPB1 TYMP RRM2-1 DHODH UCKL1 ITPA GDA DPYD CTPS1 CMPK2 TYMS TK1 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells INPP5D MAPK14 MAP2K3 GRB2 RAC1 PLCG1 LYN SYK SOS1 TNF MAP2K7 MAP2K6 BTK GAB2 PRKCA MAP2K2;MAP2K1 MAPK1 RAF1 HRAS CSF2 MAPK8 NRAS FCER1A FYN PDK1 FCER1G IL13 PLA2G4A IL4 IL3 IL5 LCP2 KRAS MS4A2 VAV3 MAP2K4 LAT PIK3R1 PIK3CA AKT1 DOXEPIN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060816 Doxepin H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 PROPIOMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063580 Propiomazine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 STEROIDOGENESIS%SMPDB%SMP0000130 Steroidogenesis HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 GASTRIC ACID PRODUCTION%SMPDB%SMP0000589 Gastric Acid Production CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 GAST FLECAINIDE ACTION PATHWAY%SMPDB%SMP0000331 Flecainide Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B S-ADENOSYLHOMOCYSTEINE (SAH) HYDROLASE DEFICIENCY%PATHWHIZ%PW000102 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency IL4I1 BHMT MTAP MAT2A CBS;CBSL CHDH CTH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B SRM GOUT OR KELLEY-SEEGMILLER SYNDROME%SMPDB%SMP0000365 Gout or Kelley-Seegmiller Syndrome GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ITPA ADA PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW064563 Pentose Phosphate Pathway THE ONCOGENIC ACTION OF L-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%PATHWHIZ%PW002451 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB GLS2 CS PC GLUD1;GLUD2 SUCLG2 L2HGDH ACO1 SUCLG1 ACO2 DLD PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0087400 Pentose Phosphate Pathway SUCCINATE SIGNALLING DURING INFLAMMATION%PATHWHIZ%PW122149 Succinate Signalling During Inflammation METHIONINE METABOLISM%SMPDB%SMP0000033 Methionine Metabolism IL4I1 BHMT MTAP MAT2A CBS;CBSL CHDH CTH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B SRM PANITUMUMAB ACTION PATHWAY%SMPDB%SMP0000475 Panitumumab Action Pathway EGFR THIAZINAMIUM H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061692 Thiazinamium H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM%SMPDB%SMP0000564 Multiple Carboxylase Deficiency, Neonatal or Early Onset Form BTD SPCS1 HLCS ACACB LANSOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000590 Lansoprazole Metabolism Pathway ATP4B ATP4A NETILMICIN ACTION PATHWAY%SMPDB%SMP0000257 Netilmicin Action Pathway HYPOACETYLASPARTIA%PATHWHIZ%PW000094 Hypoacetylaspartia IL4I1 ABAT ASS1 ADSL ASNS ASL ASRGL1 GAD1 CAD DDO DARS1 NARS1 ADSS1 ASPA ISOVALERIC ACIDURIA%PATHWHIZ%PW000091 Isovaleric Aciduria HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1)%SMPDB%SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1) HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 DOBUTAMINE ACTION PATHWAY%PATHWHIZ%PW000639 Dobutamine Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B NABUMETONE ACTION PATHWAY%SMPDB%SMP0000114 Nabumetone Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency GLYCTK GCAT GNMT GARS1 GAMT SRR SARS1 PSAT1 CTH SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD ALAS1 SHMT2 ANTRAFENINE ACTION PATHWAY%SMPDB%SMP0000693 Antrafenine Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES TAURINE AND HYPOTAURINE METABOLISM%SMPDB%SMP0000021 Taurine and Hypotaurine Metabolism CDO1 GAD1 CSAD ADO GGT6 SMITH-LEMLI-OPITZ SYNDROME (SLOS)%PATHWHIZ%PW000095 Smith-Lemli-Opitz Syndrome (SLOS) ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA LSS CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE III%PATHWHIZ%PW000193 Congenital Bile Acid Synthesis Defect Type III CH25H AMACR ACOX2 SCP2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 BAAT CYP46A1 CYP7B1 CYP8B1 CYP7A1 LIPA CYP39A1 CYP27A1 DIPYRIDAMOLE (ANTIPLATELET) ACTION PATHWAY%SMPDB%SMP0000264 Dipyridamole (Antiplatelet) Action Pathway PDE4D-1 HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]%PATHWHIZ%PW000482 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome] GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 GEFITINIB ACTION PATHWAY%SMPDB%SMP0000473 Gefitinib Action Pathway EGFR THIOGUANINE ACTION PATHWAY%PATHWHIZ%PW000429 Thioguanine Action Pathway ABCC4 SLC29A1 ABCC5 SLC28A3 TPMT ADK RAC1 SLC28A2 SLC29A2 AOX1 GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ITPA ADA PHENBENZAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060645 Phenbenzamine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 PRILOCAINE ACTION PATHWAY%PATHWHIZ%PW000407 Prilocaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 NITRENDIPINE ACTION PATHWAY%SMPDB%SMP0000382 Nitrendipine Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122064 Ribose-5-phosphate Isomerase Deficiency QUINIDINE ACTION PATHWAY%SMPDB%SMP0000323 Quinidine Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B PHENINDIONE ACTION PATHWAY%SMPDB%SMP0000655 Phenindione Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 TICLOPIDINE METABOLISM PATHWAY%SMPDB%SMP0000611 Ticlopidine Metabolism Pathway P2RY12 BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773 BTG Family Proteins and Cell Cycle Regulation TP53 BTG2 CHAF1A HOXB9 BTG1 PRMT1 NGF CCND1 FGF1 RB1 TRANEXAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000309 Tranexamic Acid Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 GLIBENCLAMIDE ACTION PATHWAY%SMPDB%SMP0000460 Glibenclamide Action Pathway ABCC8 INS;INS-IGF2 CACNA1A SLC2A2 CACNA2D2 CACNB1 ION CHANNELS AND THEIR FUNCTIONAL ROLE IN VASCULAR ENDOTHELIUM%SMPDB%SMP0063778 Ion Channels and Their Functional Role in Vascular Endothelium TRPC4 TRPV4 KCNQ2 KCNQ3 PRKG2 KCNQ4 KCNQ5 ADCY10 PRKG1 GUCY1A2 GUCY1B1 TRPC7 GUCY1A1 NOS3 TRPC3 DOXEPIN METABOLISM PATHWAY%PATHWHIZ%PW000617 Doxepin Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP1A2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TELMISARTAN ACTION PATHWAY%PATHWHIZ%PW000284 Telmisartan Action Pathway ACE REN AGT GNG2 GNAQ GNB1 AGTR1 ESMOLOL ACTION PATHWAY%SMPDB%SMP0000301 Esmolol Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY%SMPDB%SMP0000210 Purine Nucleoside Phosphorylase Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ITPA ADA LAMIVUDINE METABOLISM PATHWAY%PATHWHIZ%PW000625 Lamivudine Metabolism Pathway NT5C SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SLC22A1 SLC22A2 ABCC4 PCYT1A SLC22A3 ABCG2 CHPT1 ABCC3 PCYT2 CMPK1 ABCC1 ABCC2 ABCB1 DCK NME1 PGK1 VENLAFAXINE METABOLISM PATHWAY%PATHWHIZ%PW000612 Venlafaxine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC6A2 SLC6A4 ABCB1 GALACTOSEMIA II (GALK)%SMPDB%SMP0000495 Galactosemia II (GALK) GALT GCK UGP2 PGM1 UGDH GALE UXS1 GALK1 ROSIGLITAZONE METABOLISM PATHWAY%PATHWHIZ%PW000629 Rosiglitazone Metabolism Pathway CYP2C9;CYP2C19 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 EPLERENONE ACTION PATHWAY%SMPDB%SMP0000135 Eplerenone Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 ETOPOSIDE METABOLISM PATHWAY%PATHWHIZ%PW000577 Etoposide Metabolism Pathway PTGS2-2 TOP2B PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 ABCC3 HYOU1 PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TOP2A MPO ABCB1 OMEPRAZOLE METABOLISM PATHWAY%SMPDB%SMP0000613 Omeprazole Metabolism Pathway ATP4B ATP4A SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW121877 Sucrase-Isomaltase Deficiency ARBUTAMINE ACTION PATHWAY%SMPDB%SMP0000664 Arbutamine Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B METHADYL ACETATE ACTION PATHWAY%PATHWHIZ%PW000655 Methadyl Acetate Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 MAPLE SYRUP URINE DISEASE%PATHWHIZ%PW000064 Maple Syrup Urine Disease HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS HOMOCARNOSINOSIS%SMPDB%SMP0000385 Homocarnosinosis ABAT GFPT1 PPAT GOT2-1 GPT ALDH4A1 CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS ARSENATE DETOXIFICATION%PATHWHIZ%PW122396 Arsenate Detoxification SLC2A4 SLC2A1 PNP-1 AS3MT GSTO1 AQP9 LOC100509620;LOC112267859;AQP7 TYROSINEMIA TYPE 3 (TYRO3)%PATHWHIZ%PW000121 Tyrosinemia Type 3 (TYRO3) IL4I1 HPD FARSB GOT1-1 HGD PAH TAT FARSA FAH GSTZ1 YARS1 HISTAMINE H1 RECEPTOR ACTIVATION%SMPDB%SMP0063452 Histamine H1 Receptor Activation NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088275 Inositol Phosphate Metabolism PROTEIN SYNTHESIS: SERINE%PATHWHIZ%PW120517 Protein Synthesis: Serine RPL4 SARS1 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 LYSOPHOSPHATIDIC ACID LPA2 SIGNALLING%SMPDB%SMP0063753 Lysophosphatidic Acid LPA2 Signalling SRF GNG2 ROCK1 GNB1 ITPR1 LPAR2 AKT1 ADCY1 PLCB1 BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851 Bile Acid Indirect Signalling Pathway FGF19 NR1H4 SLC10A2 FGFR4 FGFR3 FGFR2 FGFR1 KLB GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120596 Glycogenosis, Type VII. Tarui Disease PANCREAS FUNCTION - ALPHA CELL%PATHWHIZ%PW122296 Pancreas Function - Alpha Cell ABCC8 SNTB1 SNTB2 CACNA1A SLC2A2 CACNA2D2 GCG SCN5A SNTA1 CACNB1 FLUNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061047 Flunarizine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 CARPROFEN ACTION PATHWAY%SMPDB%SMP0000694 Carprofen Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PHENPROCOUMON ACTION PATHWAY%PATHWHIZ%PW000314 Phenprocoumon Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FRUCTOSURIA%SMPDB%SMP0000561 Fructosuria FCSK FPGT PHPT1 GFUS HK1 TPI1 AKR1B1 ALDOB PFKL ALDOA FBP1 PFKFB1 PMM1 MPI SORD KHK GMPPB GMDS BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS%PATHWHIZ%PW000161 Beta Oxidation of Very Long Chain Fatty Acids PEX13 PEX14 ACSL1 CPT2 ABCD2 ABCD1 CROT SLC25A20 PEX11G CRAT INTRACELLULAR SIGNALLING THROUGH PROSTACYCLIN RECEPTOR AND PROSTACYCLIN%SMPDB%SMP0000354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin ADCY2 PRKACB-1 GNGT1 PTGIR MYL3 GNAS-1 MYLK GNB1 CHLORPHENAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW057579 Chlorphenamine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 LYSINE DEGRADATION%PATHWHIZ%PW000029 Lysine Degradation ECHS1 DLST ACAT1 DHTKD1 GCDH SLC25A2 AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593 Toll-Like Receptor Pathway 2 MAPK14 NFKB1 NFKBIA IKBKB TRAF6 IKBKG ECSIT RELA IRAK1 TLR1 TOLLIP TLR9 TAB3 TLR8 TAB2 TLR7 TLR6 TAB1 MAPK8 TLR5 TLR3 TLR2 MAP3K7 LY96 MAP2K4 TIRAP CD14 TLR4 MYD88 MAP3K1 CHUK GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY (GAMT DEFICIENCY)%SMPDB%SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 IRINOTECAN METABOLISM PATHWAY%SMPDB%SMP0000600 Irinotecan Metabolism Pathway PDIA2 UGT1A1;UGT1A6 PDIA6 ABCG2 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 BCHE ABCC1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC2 TOP1 ABCB1 CES2 CES1 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0120584 Ribose-5-phosphate Isomerase Deficiency QUIFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061693 Quifenadine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 HYDROCODONE ACTION PATHWAY%SMPDB%SMP0000411 Hydrocodone Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PANTOTHENATE AND COA BIOSYNTHESIS%SMPDB%SMP0000027 Pantothenate and CoA Biosynthesis VNN1 PPCS COASY PPCDC PANK1 ENPP1 METOPROLOL ACTION PATHWAY%PATHWHIZ%PW000370 Metoprolol Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0000031 Pentose Phosphate Pathway GPI G6PD TALDO1 PGD DERA RPIA PFKL RPE;RPEL1 PGLS ALDOA TKT FBP1 PGM1 RBKS TRIFUNCTIONAL PROTEIN DEFICIENCY%SMPDB%SMP0000545 Trifunctional Protein Deficiency ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS MOLYBDENUM COFACTOR DEFICIENCY%SMPDB%SMP0000203 Molybdenum Cofactor Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ITPA ADA SOTALOL ACTION PATHWAY%SMPDB%SMP0000660 Sotalol Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B NON-KETOTIC HYPERGLYCINEMIA%PATHWHIZ%PW000209 Non-Ketotic Hyperglycinemia GLYCTK GCAT GNMT GARS1 GAMT SRR SARS1 PSAT1 CTH SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD ALAS1 SHMT2 MOEXIPRIL ACTION PATHWAY%SMPDB%SMP0000151 Moexipril Action Pathway ACE REN AGT 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17)%PATHWHIZ%PW000542 17-alpha-Hydroxylase Deficiency (CYP17) HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 LEVOCETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060053 Levocetirizine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 TEMELASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063837 Temelastine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2A AND ADENOSINE%SMPDB%SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine ELK1 PRKACB-1 GNGT1 NFKB1 PDPK1 NFKBIA CREB1 IKBKB RPS6KA1 GNAS-1 GNB1 MAP2K7 MAP2K6 BAD MAP2K2;MAP2K1 MAPK1 HRAS MAPK8 PAK1 ATF2 PRKCZ PARD6A RAP1A MAP3K4 BRAF NFKB2 MAPK11 ADORA2A JUN RAPGEF2 ARHGEF7 RAPGEF3 CDC42 PIK3CA MAP3K1 AKT1 CHUK ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%PATHWHIZ%PW000726 Activation of PKC Through G Protein-Coupled Receptor PRKCA GNAQ ITPR1 PLCB1 HAWKINSINURIA%PATHWHIZ%PW000181 Hawkinsinuria DCT ALDH3A1 PNMT GOT1-1 ADH1C;ADH1B;ADH1A DDC AOC1 HGD MAOA HAAO MIF DBH TYR COMT FAH GSTZ1 FOLATE MALABSORPTION, HEREDITARY%PATHWHIZ%PW000701 Folate Malabsorption, Hereditary FTCD ST20-MTHFS;MTHFS SLC46A1 MTFMT ALDH1L1 MTHFD1L MTHFD1 MTHFD2 MTHFR FPGS GGH DHFR2;DHFR SUFENTANIL ACTION PATHWAY%PATHWHIZ%PW000423 Sufentanil Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CLOCINIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062788 Clocinizine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 PROPANOATE METABOLISM%SMPDB%SMP0000016 Propanoate Metabolism ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT ACADM MLYCD ACSS1 HIBCH LDHAL6B DLD BCKDHA ACSS3 TRICHLORMETHIAZIDE ACTION PATHWAY%SMPDB%SMP0000121 Trichlormethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 FATTY ACID ELONGATION IN MITOCHONDRIA%SMPDB%SMP0000054 Fatty Acid Elongation in Mitochondria ECHS1 HADHB-1 ACAA2 MECR PPT1 HADHA HSD17B10 ALVIMOPAN ACTION PATHWAY%SMPDB%SMP0000685 Alvimopan Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PROTEIN SYNTHESIS: THREONINE%PATHWHIZ%PW120525 Protein Synthesis: Threonine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 TARS1 SIMVASTATIN ACTION PATHWAY%PATHWHIZ%PW000127 Simvastatin Action Pathway ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA LSS FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW121882 Fructose-1,6-diphosphatase Deficiency WARBURG EFFECT%PATHWHIZ%PW088382 Warburg Effect PTERINE BIOSYNTHESIS%PATHWHIZ%PW000140 Pterine Biosynthesis CBR1-1 PTS GCHFR QDPR SPR GCH1 AKR1B1 DHFR2;DHFR NUCLEOTIDE SUGARS METABOLISM%PATHWHIZ%PW000031 Nucleotide Sugars Metabolism GALT GCK UGP2 PGM1 UGDH GALE UXS1 GALK1 PYRUVATE DEHYDROGENASE DEFICIENCY (E3)%SMPDB%SMP0000550 Pyruvate Dehydrogenase Deficiency (E3) FH MDH1 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD 3-METHYLTHIOFENTANYL ACTION PATHWAY%PATHWHIZ%PW000656 3-Methylthiofentanyl Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW120529 Protein Synthesis: Alanine VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436 Vinblastine Action Pathway ABCC3 CDKN1A TUBB1 ABCC10 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TP53 ABCC1 ABCC2 ABCB1 RALBP1-1 QUINAPRIL METABOLISM PATHWAY%SMPDB%SMP0000596 Quinapril Metabolism Pathway ACE CARVEDILOL ACTION PATHWAY%SMPDB%SMP0000367 Carvedilol Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 ADRA1A KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B TRANDOLAPRIL ACTION PATHWAY%SMPDB%SMP0000157 Trandolapril Action Pathway ACE REN AGT BETAHISTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061694 Betahistine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 DEMECLOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000358 Demeclocycline Action Pathway INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0063630 Inositol Phosphate Metabolism ESOMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000315 Esomeprazole Action Pathway CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 GAST SARCOSINEMIA%SMPDB%SMP0000244 Sarcosinemia GLYCTK GCAT GNMT GARS1 GAMT SRR SARS1 PSAT1 CTH SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD ALAS1 SHMT2 LYSINURIC PROTEIN INTOLERANCE (LPI)%SMPDB%SMP0000585 Lysinuric Protein Intolerance (LPI) SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 QUETIAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062884 Quetiapine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 UBIQUINONE BIOSYNTHESIS%SMPDB%SMP0000065 Ubiquinone Biosynthesis COQ3 COQ2 COQ7 COQ6 COQ5 EPINASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062142 Epinastine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0120864 Glycogenosis, Type IA. Von Gierke Disease XANTHINE DEHYDROGENASE DEFICIENCY (XANTHINURIA)%SMPDB%SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria) GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ITPA ADA GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW122117 Glycogenosis, Type IB GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120838 Glycogenosis, Type VI. Hers Disease AZITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000345 Azithromycin Action Pathway PYRUVATE DEHYDROGENASE DEFICIENCY (E2)%SMPDB%SMP0000551 Pyruvate Dehydrogenase Deficiency (E2) FH MDH1 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD TRISALICYLATE-CHOLINE ACTION PATHWAY%PATHWHIZ%PW000680 Trisalicylate-Choline Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES HISTIDINEMIA%PATHWHIZ%PW000113 Histidinemia CNDP1 HAL ALDH2 FTCD ALDH3A1 HARS1 CARNMT1 HDC PRMT3 AOC1 HNMT HARS2 MAOA CNDP2 UROC1 AMDHD1 CARNS1 CILOSTAZOL ACTION PATHWAY%SMPDB%SMP0000263 Cilostazol Action Pathway CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PDE4D-1 MONOAMINE OXIDASE-A DEFICIENCY (MAO-A)%PATHWHIZ%PW000509 Monoamine Oxidase-A Deficiency (MAO-A) DCT ALDH3A1 PNMT GOT1-1 ADH1C;ADH1B;ADH1A DDC AOC1 HGD MAOA HAAO MIF DBH TYR COMT FAH GSTZ1 FENETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059707 Fenethazine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 MITOCHONDRIAL BETA-OXIDATION OF MEDIUM CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000172 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids ECHS1 HADHB-1 ACAA2 HADHA ACSM1 ACADM SLC25A20 HADH ROXITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000251 Roxithromycin Action Pathway SULFATE SULFITE METABOLISM%PATHWHIZ%PW000040 Sulfate Sulfite Metabolism SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SULT2B1 CHST11 BPNT1 SUOX PAPSS2 ANDROSTENEDIONE METABOLISM%SMPDB%SMP0030406 Androstenedione Metabolism HSD11B1 PDIA2 UGT1A1;UGT1A6 PDIA6 CYP11B1;CYP11B2 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 SRD5A1 HSD17B3 AKR1D1 CYP19A1 CYCLOPHOSPHAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000580 Cyclophosphamide Metabolism Pathway ALDH3A1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 GSTM1;GSTM2-1 THE ONCOGENIC ACTION OF SUCCINATE%PATHWHIZ%PW002360 The Oncogenic Action of Succinate FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A EGLN1 EGLN3 EGLN2 PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 SLC25A10 ACO1 SUCLG1 ACO2 DLD BEVACIZUMAB ACTION PATHWAY%SMPDB%SMP0000420 Bevacizumab Action Pathway KDR FLT1 VEGFA NEOMYCIN ACTION PATHWAY%SMPDB%SMP0000256 Neomycin Action Pathway MORPHINE METABOLISM PATHWAY%SMPDB%SMP0000622 Morphine Metabolism Pathway HYOU1 OPRM1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW000916 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) BROMODIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059740 Bromodiphenhydramine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120585 Transaldolase Deficiency KETOPROFEN ACTION PATHWAY%SMPDB%SMP0000085 Ketoprofen Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES LIDOCAINE (LOCAL ANAESTHETIC) ACTION PATHWAY%SMPDB%SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS%SMPDB%SMP0029731 Phosphatidylethanolamine Biosynthesis PTDSS1 CEPT1 CHKA PCYT2 PISD METHYLMALONIC ACIDURIA%SMPDB%SMP0000200 Methylmalonic Aciduria HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS PROTEIN SYNTHESIS: TYROSINE%PATHWHIZ%PW120527 Protein Synthesis: Tyrosine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 YARS1 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 BETA-KETOTHIOLASE DEFICIENCY%SMPDB%SMP0000173 beta-Ketothiolase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS GLYCOLYSIS%SMPDB%SMP0063478 Glycolysis LORNOXICAM ACTION PATHWAY%PATHWHIZ%PW000677 Lornoxicam Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES INOSITOL METABOLISM%SMPDB%SMP0000011 Inositol Metabolism IPPK PIKFYVE MIOX ISYNA1 INPP1 ITPK1 IPMK PI4KA INPP4A MINPP1 IMPA1 PIK3C3 ITPKA INPP5J PLCD3 VAC14 BECN1 PIK3R4 AMBRA1 PIK3CA PTPMT1 FIG4 PROPARACAINE ACTION PATHWAY%PATHWHIZ%PW000409 Proparacaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 FLAVONOID BIOSYNTHESIS%SMPDB%SMP0012021 Flavonoid Biosynthesis ROPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000410 Ropivacaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 XANTHINURIA TYPE II%PATHWHIZ%PW000489 Xanthinuria Type II GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ITPA ADA VALPROIC ACID METABOLISM PATHWAY%SMPDB%SMP0000635 Valproic Acid Metabolism Pathway HADHB-1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ACADSB HADHA CYP2B6 ACSM1 IVD EHHADH-1 HSD17B10 PROTEIN SYNTHESIS: ASPARTIC ACID%SMPDB%SMP0111858 Protein Synthesis: Aspartic Acid DARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 LACTOSE INTOLERANCE%PATHWHIZ%PW000206 Lactose Intolerance ATP1A1 LCT SLC2A2 FXYD2;FXYD6-FXYD2 ATP1B2 SLC5A1-1 ATP1B1 ATP1A4 ATP1A3 ATP1A2 ATP1B3-1 CILAZAPRIL ACTION PATHWAY%SMPDB%SMP0000147 Cilazapril Action Pathway ACE REN AGT METIPRANOLOL ACTION PATHWAY%PATHWHIZ%PW000644 Metipranolol Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B FOSPHENYTOIN (ANTIARRHYTHMIC) METABOLISM PATHWAY%SMPDB%SMP0000618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway SNTB1 SNTB2 SCN5A SNTA1 LEVOCABASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060224 Levocabastine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 TENECTEPLASE ACTION PATHWAY%SMPDB%SMP0000283 Tenecteplase Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 3-HYDROXYISOBUTYRIC ACID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS NEVIRAPINE METABOLISM PATHWAY%PATHWHIZ%PW000618 Nevirapine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 ALDH1A1 ABCC10 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 DEXCHLORPHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056811 Dexchlorpheniramine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW090995 g-Secretase Mediated ErbB4 Signalling Pathway PSEN1 NRG2 PRKCA ADAM17 EGFR ERBB3 ERBB4 RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795 Rac 1 Cell Motility Signaling Pathway PAK1 PCNA RAC1 CCND1 CDKN1A CAP1 VAV3 PDGFRA WASF1-1 LIMK1 CCND3 CDK5 PLD1 ACTB-1 MYLK RPS6KB1 MYL2 CFL1 ARFIP2 PPP1R12B MAP3K1 RALBP1-1 D-ARGININE AND D-ORNITHINE METABOLISM%PATHWHIZ%PW000019 D-Arginine and D-Ornithine Metabolism DAO TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW000539 Triosephosphate Isomerase Deficiency SLC2A2 MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 HOMOCYSTEINE DEGRADATION%SMPDB%SMP0000455 Homocysteine Degradation CBS;CBSL CTH KETOBEMIDONE ACTION PATHWAY%SMPDB%SMP0000690 Ketobemidone Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOLYSIS%PATHWHIZ%PW000146 Glycolysis PFKM PKLR SLC2A2 GPI PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 GALM-2 G6PC1 PGK1 METACHROMATIC LEUKODYSTROPHY (MLD)%SMPDB%SMP0000347 Metachromatic Leukodystrophy (MLD) PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC NEU3 UGCG UGT8 ACER1 SGPL1 SPTLC1 ACER3 KDSR DEGS2 B4GALT6 ENPP7 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%SMPDB%SMP0120617 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis NF-KB SIGNALING PATHWAY%PATHWHIZ%PW064818 NF-kB Signaling Pathway NFKB1 NFKBIA IKBKB TRAF6 IKBKG TRADD TNF RIPK1 RELA IRAK1 CAMKK2 IL1R1 NCOA3 TNFRSF1B TNFRSF1A IL1A MAP3K14 TAB1 CAMKK1 UBB;UBC FADD MAP3K7 TLR4 MYD88 MAP3K1 CHUK METHYLHISTIDINE METABOLISM%PATHWHIZ%PW000692 Methylhistidine Metabolism ACTB-1 GLYCINE N-METHYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000222 Glycine N-Methyltransferase Deficiency IL4I1 BHMT MTAP MAT2A CBS;CBSL CHDH CTH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B SRM LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD)%PATHWHIZ%PW000515 Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS DEPTROPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062883 Deptropine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 METHADONE ACTION PATHWAY%PATHWHIZ%PW000414 Methadone Action Pathway CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 CYP2B6 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 BROMFENAC ACTION PATHWAY%SMPDB%SMP0000102 Bromfenac Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES ROXATIDINE ACETATE ACTION PATHWAY%PATHWHIZ%PW000711 Roxatidine Acetate Action Pathway CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 GAST WARBURG EFFECT%SMPDB%SMP0087270 Warburg Effect CERIVASTATIN ACTION PATHWAY%PATHWHIZ%PW000271 Cerivastatin Action Pathway ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA LSS OXOMEMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060682 Oxomemazine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW000150 Starch and Sucrose Metabolism UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GPI MGAM GBE1 PYGL HK2 GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598 Ponatinib Inhibition of BCR-ABL STAT5A GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 TP53 GAB2 CBL MTOR CRKL RPS6KB1 PIK3R1 MYC SKP2 CRK BCL2L1 ALPHA LINOLENIC ACID AND LINOLEIC ACID METABOLISM%PATHWHIZ%PW000006 Alpha Linolenic Acid and Linoleic Acid Metabolism FADS2 ELOVL4 ELOVL5 FADS1 JMJD7-PLA2G4B;PLA2G4B OXYMORPHONE ACTION PATHWAY%PATHWHIZ%PW000418 Oxymorphone Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CARFENTANIL ACTION PATHWAY%SMPDB%SMP0000414 Carfentanil Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GAMMA-GLUTAMYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000110 gamma-Glutamyltransferase Deficiency GSS GSR GCLC CASP7 GGCT GCLM GGT6 GPX1 GSTO2 ANPEP OPLAH KRABBE DISEASE%PATHWHIZ%PW000502 Krabbe Disease PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC NEU3 UGCG UGT8 ACER1 SGPL1 SPTLC1 ACER3 KDSR DEGS2 B4GALT6 ENPP7 PORPHYRIN METABOLISM%SMPDB%SMP0000024 Porphyrin Metabolism UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 BLVRA COX10 GUSB ALAS1 ANDROGEN AND ESTROGEN METABOLISM%SMPDB%SMP0000068 Androgen and Estrogen Metabolism SULT2B1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 STS SRD5A1 HSD17B1 HSD17B3 HSD3B1;HSD3B2 AKR1D1 CYP19A1 CYP17A1 BETAINE METABOLISM%SMPDB%SMP0000123 Betaine Metabolism BHMT MAT2A CHDH ALDH7A1 PEMT AHCY MAT2B MTR-1 BIOTINIDASE DEFICIENCY%SMPDB%SMP0000174 Biotinidase Deficiency BTD SPCS1 HLCS ACACB FUROSEMIDE ACTION PATHWAY%PATHWHIZ%PW000337 Furosemide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 DESLORATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060201 Desloratadine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 ENALAPRIL ACTION PATHWAY%SMPDB%SMP0000148 Enalapril Action Pathway ACE REN AGT ERYTHROMYCIN ACTION PATHWAY%SMPDB%SMP0000250 Erythromycin Action Pathway LEVOMETHADYL ACETATE ACTION ACTION PATHWAY%SMPDB%SMP0000677 Levomethadyl Acetate Action Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PROTEIN SYNTHESIS: CYSTEINE%PATHWHIZ%PW112918 Protein Synthesis: Cysteine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 CARS1 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597 Bafetinib Inhibition of BCR-ABL STAT5A GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 TP53 GAB2 CBL MTOR CRKL RPS6KB1 PIK3R1 MYC SKP2 CRK BCL2L1 PYRUVATE CARBOXYLASE DEFICIENCY%SMPDB%SMP0000350 Pyruvate Carboxylase Deficiency PC MPC1 AGXT GPT AARS2 CETUXIMAB ACTION PATHWAY%SMPDB%SMP0000474 Cetuximab Action Pathway EGFR FELODIPINE ACTION PATHWAY%PATHWHIZ%PW000392 Felodipine Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B MYCOPHENOLIC ACID METABOLISM PATHWAY%PATHWHIZ%PW000628 Mycophenolic Acid Metabolism Pathway UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 IMPDH1 IMPDH2 ABCG2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC2 ABCB1 CES2 CES1 RETINOL METABOLISM%SMPDB%SMP0000074 Retinol Metabolism CYP26A1 DHRS9 ALDH1A2 PNPLA4 PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 CYP2A13;CYP2A6;CYP2A7-1 HYOU1 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 ADH1C;ADH1B;ADH1A RETSAT RDH8 RDH12 AWAT1 RDH11 LRAT BCO1 DGAT1 DHRS3 RPE65 DHRS4 DESIPRAMINE ACTION PATHWAY%PATHWHIZ%PW000425 Desipramine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DOPAMINE BETA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000498 Dopamine beta-Hydroxylase Deficiency DCT ALDH3A1 PNMT GOT1-1 ADH1C;ADH1B;ADH1A DDC AOC1 HGD MAOA HAAO MIF DBH TYR COMT FAH GSTZ1 CLOPIDOGREL ACTION PATHWAY%PATHWHIZ%PW000286 Clopidogrel Action Pathway CYP1A2 CYP2C9;CYP2C19 PON1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 P2RY12 ABCB1 TETRACYCLINE ACTION PATHWAY%SMPDB%SMP0000294 Tetracycline Action Pathway EPINEPHRINE ACTION PATHWAY%PATHWHIZ%PW000638 Epinephrine Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B 3-METHYLGLUTACONIC ACIDURIA TYPE IV%SMPDB%SMP0000141 3-Methylglutaconic Aciduria Type IV HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS THYROID HORMONE SYNTHESIS%PATHWHIZ%PW000693 Thyroid Hormone Synthesis DUOX2 SLC5A5 DUOX1 TPO TG NOX3 NOX4 CYBB CYBA HYDROXYZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058936 Hydroxyzine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087197 Fructose and Mannose Degradation INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2B AND ADENOSINE%SMPDB%SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine ELK1 PRKACB-1 GNGT1 NFKB1 PDPK1 NFKBIA CREB1 IKBKB RPS6KA1 GNAS-1 GNB1 MAP2K7 MAP2K6 BAD MAP2K2;MAP2K1 MAPK1 HRAS ADCY2 MAPK8 PAK1 ATF2 PRKCZ PARD6A RAP1A MAP3K4 BRAF NFKB2 ADORA2B MAPK11 JUN RAPGEF2 ARHGEF7 RAPGEF3 CDC42 PIK3CA MAP3K1 AKT1 CHUK FANCONI-BICKEL SYNDROME%SMPDB%SMP0000572 Fanconi-Bickel Syndrome PFKM PKLR SLC2A2 GPI PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 GALM-2 G6PC1 PGK1 ROSUVASTATIN ACTION PATHWAY%SMPDB%SMP0000092 Rosuvastatin Action Pathway ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA LSS PAROMOMYCIN ACTION PATHWAY%PATHWHIZ%PW000691 Paromomycin Action Pathway PANCREAS FUNCTION - DELTA CELL%PATHWHIZ%PW122406 Pancreas Function - Delta Cell ABCC8 CACNA1A SLC2A2 CACNA2D2 CACNB1 SST LEUCINE STIMULATION ON INSULIN SIGNALING%SMPDB%SMP0000682 Leucine Stimulation on Insulin Signaling PIK3CG INS;INS-IGF2 IRS1 PIK3R6 INSR IRS2 SLC7A5 TSC2 TSC1 RHEB EIF4EBP1 MTOR EIF4E RPS6KB1 AKT1 HYPERPHENYLALANINEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY%SMPDB%SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency CBR1-1 PTS GCHFR QDPR SPR GCH1 AKR1B1 DHFR2;DHFR SUCCINYL COA: 3-KETOACID COA TRANSFERASE DEFICIENCY%SMPDB%SMP0000569 Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency HMGCL BDH1 ACAT1 OXCT1-1 BOPINDOLOL ACTION PATHWAY%SMPDB%SMP0000657 Bopindolol Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B CEREBROTENDINOUS XANTHOMATOSIS (CTX)%PATHWHIZ%PW000196 Cerebrotendinous Xanthomatosis (CTX) CH25H AMACR ACOX2 SCP2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 BAAT CYP46A1 CYP7B1 CYP8B1 CYP7A1 LIPA CYP39A1 CYP27A1 SUCCINATE SIGNALLING%PATHWHIZ%PW084312 Succinate Signalling TLR4 IL1B NLRP3 HIF1A SIRT3 P4HA3 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW122118 Glycogenosis, Type IC ARTEMETHER METABOLISM PATHWAY%PATHWHIZ%PW000627 Artemether Metabolism Pathway UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 3-METHYLGLUTACONIC ACIDURIA TYPE III%SMPDB%SMP0000140 3-Methylglutaconic Aciduria Type III HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000117 Pyruvate Dehydrogenase Complex Deficiency ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD REMIFENTANIL ACTION PATHWAY%PATHWHIZ%PW000422 Remifentanil Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 IRBESARTAN ACTION PATHWAY%PATHWHIZ%PW000281 Irbesartan Action Pathway ACE REN AGT GNG2 GNAQ GNB1 AGTR1 TRANDOLAPRIL METABOLISM PATHWAY%PATHWHIZ%PW000575 Trandolapril Metabolism Pathway ACE NALBUPHINE ACTION PATHWAY%SMPDB%SMP0000691 Nalbuphine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 OPRK1 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 4 AND SEROTONIN%PATHWHIZ%PW000441 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin PRKACB-1 GNGT1 CREB1 PPP1CA GNAS-1 GNB1 HTR4 ESTRONE METABOLISM%SMPDB%SMP0030880 Estrone Metabolism PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 CYP1A1 HYOU1 HSD17B1 COMT MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD)%PATHWHIZ%PW000518 Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS BILASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061119 Bilastine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 THENALIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062894 Thenalidine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 TRASTUZUMAB ACTION PATHWAY%SMPDB%SMP0000476 Trastuzumab Action Pathway EGFR NIMODIPINE ACTION PATHWAY%PATHWHIZ%PW000395 Nimodipine Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B GNRH SIGNALING PATHWAY%PATHWHIZ%PW064816 GnRH Signaling Pathway LHB CAMK2A ELK1 GNA11 MAPK14 GNRHR MAP3K2 EGR1 CGA MAP2K3 FSHB MMP2 ACTN4 GNAS-1 GRB2 MMP14 GNRH1 PRKCB SOS1 HBEGF ATF4 ITPR1 PLCB1 MAP2K7 CACNA1D PRKCA CACNA1F JMJD7-PLA2G4B;PLA2G4B MAP2K2;MAP2K1 MAPK1 CACNA1S RAF1 HRAS CACNA1C PRKACA-1 MAPK8 JUN CACNA2D2 PLD1 CACNB1 CDC42 EGFR MAP3K1 SRC CALML6 ADCY1 TENOXICAM ACTION PATHWAY%SMPDB%SMP0000706 Tenoxicam Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES NISOLDIPINE ACTION PATHWAY%PATHWHIZ%PW000396 Nisoldipine Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B FLUOROURACIL ACTION PATHWAY%SMPDB%SMP0000470 Fluorouracil Action Pathway TYMS INOSITOL METABOLISM%PATHWHIZ%PW088354 Inositol Metabolism VERY-LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (VLCAD)%SMPDB%SMP0000540 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS ESCITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000427 Escitalopram Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909 Toll-Like Receptor Pathway 1 FOS ELK1 MAPK14 NFKB1 NFKBIA IKBKB MAP2K3 TRAF6 IKBKG EIF2AK2 PPARA MAP2K6 ECSIT RELA IRAK1 TOLLIP TLR9 TAB2 TLR7 TAB1 MAPK8 TLR3 TLR2 MAP3K7 LY96 MAP2K4 TIRAP JUN CD14 TLR4 MYD88 MAP3K1 CHUK CARDIOLIPIN BIOSYNTHESIS%SMPDB%SMP0020986 Cardiolipin Biosynthesis CDS2 PGS1 GPAM PTPMT1 GPD1 AGPAT5-1 CRLS1 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977 T Cell Receptor Signaling Pathway FOS ELK1 NFKB1 NFKBIA PPP3CA PPP3CB PPP3CC GRB2 RAC1 PLCG1 PRKCB SOS1 NFATC3 NFATC2 SHC1-1 NFATC1 CD3G CALM3;CALM1 CD3E NFATC4 CD3D RASGRP1 ZAP70 LCK PTPN7 CD247 PRKCA RELA MAP2K2;MAP2K1 RAF1 HRAS MAPK3 VAV1 PIK3CG MAPK8 FYN UBB;UBC MAP2K4 LAT JUN PIK3R1 PIK3CA MAP3K1 MERCAPTOPURINE METABOLISM PATHWAY%SMPDB%SMP0000609 Mercaptopurine Metabolism Pathway ABCC4 SLC29A1 ABCC5 SLC28A3 XDH TPMT ADK PPAT RAC1 SLC28A2 SLC29A2 HPRT1 IMPDH1 AOX1 GMPS FELODIPINE METABOLISM PATHWAY%SMPDB%SMP0000619 Felodipine Metabolism Pathway CACNA1C CACNA2D2 CACNB1 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway PTK2B P2RY2 PRKCA PLCG1 PRKCB MYOADENYLATE DEAMINASE DEFICIENCY%PATHWHIZ%PW000513 Myoadenylate Deaminase Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ITPA ADA HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, CBLG COMPLEMENTATION TYPE%SMPDB%SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type IL4I1 BHMT MTAP MAT2A CBS;CBSL CHDH CTH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B SRM MEQUITAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059720 Mequitazine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 BUPIVACAINE ACTION PATHWAY%SMPDB%SMP0000393 Bupivacaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 MNGIE (MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY)%PATHWHIZ%PW000190 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) DCTD NT5C2 RRM2B CDA DUT DPYS NME6 CAD CANT1 AK3 UPB1 TYMP RRM2-1 DHODH UCKL1 ITPA GDA DPYD CTPS1 CMPK2 TYMS TK1 NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0063777 Nitric Oxide Signaling Pathway NOS1 PRKACB-1 GRIN1 GRIN3A PPP3CA XDH DLG4 PRKCA ALDH2 GRIN2A ITPR1 CALM3;CALM1 METHAPYRILENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058741 Methapyrilene H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 WARBURG EFFECT%SMPDB%SMP0087420 Warburg Effect TALASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058511 Talastine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 HYPOPHOSPHATASIA%SMPDB%SMP0000503 Hypophosphatasia AOX1 PDXK PNPO PDXP ALPL PRAVASTATIN ACTION PATHWAY%SMPDB%SMP0000089 Pravastatin Action Pathway ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA LSS SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency ABAT GFPT1 PPAT GOT2-1 GPT ALDH4A1 CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS JOUBERT SYNDROME%SMPDB%SMP0000582 Joubert Syndrome PIKFYVE SYNJ1 INPP5D ERBB2 INPP5E PI4KA PIP5K1A PIP4K2A PIK3C3 CDIPT PLCB1 VAC14 BECN1 PTEN PIK3R4 PIK3CD PIK3R1 AMBRA1 PIK3C2A EGFR FIG4 INPP4B ADRENAL HYPERPLASIA TYPE 5 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 17 ALPHA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 FLUOXETINE ACTION PATHWAY%PATHWHIZ%PW000428 Fluoxetine Action Pathway CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 APPARENT MINERALOCORTICOID EXCESS SYNDROME%SMPDB%SMP0000717 Apparent Mineralocorticoid Excess Syndrome HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 CYSTINOSIS, OCULAR NONNEPHROPATHIC%PATHWHIZ%PW000699 Cystinosis, Ocular Nonnephropathic CDO1 GOT1-1 GCLC CTH LDHA GCLM MPST CTNS CARS1 BILE ACID DIRECT SIGNALLING PATHWAY (1)%PATHWHIZ%PW087627 Bile Acid Direct Signalling Pathway (1) NR1H4 SLC10A2 ABCC4 GPBAR1 SLCO1A2 OXIDATION OF BRANCHED-CHAIN FATTY ACIDS%SMPDB%SMP0000030 Oxidation of Branched-Chain Fatty Acids PEX13 PEX14 ACSL1 CPT2 ABCD2 HACL1 ALDH2 PHYH-4 ABCD1 SLC25A20 CRAT ARDEPARIN ACTION PATHWAY%SMPDB%SMP0000275 Ardeparin Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 SERPINC1 CHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058931 Chlorcyclizine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 FENOPROFEN ACTION PATHWAY%SMPDB%SMP0000696 Fenoprofen Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES NEURON FUNCTION%SMPDB%SMP0000224 Neuron Function PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%PATHWHIZ%PW121967 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease GLUT-1 DEFICIENCY SYNDROME%SMPDB%SMP0000580 GLUT-1 Deficiency Syndrome SLC35A2 B4GALT1 GALT UGP2 CANT1 CMPK1 SLC2A1 NME2 LALBA G6PC1 ROFECOXIB ACTION PATHWAY%SMPDB%SMP0000087 Rofecoxib Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES DIPHENYLPYRALINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059841 Diphenylpyraline H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 FLUOROURACIL METABOLISM PATHWAY%SMPDB%SMP0000608 Fluorouracil Metabolism Pathway TYMS DIHYDROMORPHINE ACTION PATHWAY%PATHWHIZ%PW000666 Dihydromorphine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW121893 Glycogenosis, Type IB GENTAMICIN ACTION PATHWAY%SMPDB%SMP0000254 Gentamicin Action Pathway LESCH-NYHAN SYNDROME (LNS)%SMPDB%SMP0000364 Lesch-Nyhan Syndrome (LNS) GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ITPA ADA SORAFENIB METABOLISM PATHWAY%PATHWHIZ%PW000624 Sorafenib Metabolism Pathway PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 PRIMARY HYPEROXALURIA II, PH2%SMPDB%SMP0000558 Primary Hyperoxaluria II, PH2 ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD TRITOQUALINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062895 Tritoqualine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY TYPE I%SMPDB%SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS SPHINGOLIPID METABOLISM%SMPDB%SMP0000034 Sphingolipid Metabolism PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC NEU3 UGCG UGT8 ACER1 SGPL1 SPTLC1 ACER3 KDSR DEGS2 B4GALT6 ENPP7 21-HYDROXYLASE DEFICIENCY (CYP21)%SMPDB%SMP0000576 21-Hydroxylase Deficiency (CYP21) HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000242 Dimethylglycine Dehydrogenase Deficiency GLYCTK GCAT GNMT GARS1 GAMT SRR SARS1 PSAT1 CTH SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD ALAS1 SHMT2 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000484 Dimethylglycine Dehydrogenase Deficiency GLYCTK GCAT GNMT GARS1 GAMT SRR SARS1 PSAT1 CTH SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD ALAS1 SHMT2 GLYCOLYSIS%PATHWHIZ%PW088336 Glycolysis CORTICOTROPIN ACTIVATION OF CORTISOL PRODUCTION%SMPDB%SMP0000310 Corticotropin Activation of Cortisol Production GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120618 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease IFOSFAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000581 Ifosfamide Metabolism Pathway ALDH3A1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 ESOMEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000588 Esomeprazole Metabolism Pathway ATP4B ATP4A NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0108236 Nitric Oxide Signaling Pathway AHR SIGNAL TRANSDUCTION PATHWAY%PATHWHIZ%PW064763 Ahr Signal Transduction Pathway HSP90AA1 ARNT AHR EGF SIGNALLING PATHWAY%SMPDB%SMP0120948 EGF Signalling Pathway LYSOPHOSPHATIDIC ACID LPA6 SIGNALLING%PATHWHIZ%PW064749 Lysophosphatidic Acid LPA6 Signalling SRF GNAS-1 GNG2 LPAR6 ROCK1 GNB1 AKT1 ADCY1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0000064 Fructose and Mannose Degradation FCSK FPGT PHPT1 GFUS HK1 TPI1 AKR1B1 ALDOB PFKL ALDOA FBP1 PFKFB1 PMM1 MPI SORD KHK GMPPB GMDS GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120619 Glycogenosis, Type VI. Hers Disease PRACTOLOL ACTION PATHWAY%PATHWHIZ%PW000646 Practolol Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120815 Glycogenosis, Type VII. Tarui Disease PAMIDRONATE ACTION PATHWAY%PATHWHIZ%PW000273 Pamidronate Action Pathway ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA LSS PROLIDASE DEFICIENCY (PD)%PATHWHIZ%PW000083 Prolidase Deficiency (PD) GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 BILE ACID BIOSYNTHESIS%SMPDB%SMP0000035 Bile Acid Biosynthesis CH25H AMACR ACOX2 SCP2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 BAAT CYP46A1 CYP7B1 CYP8B1 CYP7A1 LIPA CYP39A1 CYP27A1 ZOLEDRONATE ACTION PATHWAY%PATHWHIZ%PW000270 Zoledronate Action Pathway ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA LSS GLUTATHIONE SYNTHETASE DEFICIENCY%PATHWHIZ%PW000073 Glutathione Synthetase Deficiency GSS GSR GCLC CASP7 GGCT GCLM GGT6 GPX1 GSTO2 ANPEP OPLAH CLOMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000615 Clomipramine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP1A2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CLARITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000248 Clarithromycin Action Pathway SULINDAC ACTION PATHWAY%PATHWHIZ%PW000136 Sulindac Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES LEVOMETHADYL ACETATE METABOLISM PATHWAY%PATHWHIZ%PW000614 Levomethadyl Acetate Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0063614 Fructose and Mannose Degradation PROTEIN SYNTHESIS: HISTIDINE%PATHWHIZ%PW112929 Protein Synthesis: Histidine HARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%PATHWHIZ%PW000917 Glycerol Metabolism IV (Glycerophosphoglycerol) RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0000519 Ribose-5-phosphate Isomerase Deficiency GPI G6PD TALDO1 PGD DERA RPIA PFKL RPE;RPEL1 PGLS ALDOA TKT FBP1 PGM1 RBKS DESIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000602 Desipramine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 SLC6A2 SLC6A4 HYDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000335 Hydroflumethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 INTRACELLULAR SIGNALLING THROUGH LHCGR RECEPTOR AND LUTEINIZING HORMONE CHORIOGONADOTROPIN%SMPDB%SMP0000338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone Choriogonadotropin LHB ADCY2 PRKACB-1 GNGT1 CREB1 CGA PPP1CA GNAS-1 LHCGR GNB1 LACTOSE DEGRADATION%SMPDB%SMP0000457 Lactose Degradation ATP1A1 LCT SLC2A2 FXYD2;FXYD6-FXYD2 ATP1B2 SLC5A1-1 ATP1B1 ATP1A4 ATP1A3 ATP1A2 ATP1B3-1 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%SMPDB%SMP0000562 Fructose-1,6-diphosphatase Deficiency SLC2A2 MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 GLYCEROLIPID METABOLISM%SMPDB%SMP0000039 Glycerolipid Metabolism ALDH3A1 GLYCTK AGPAT1 GPD2 LIPC LPL PLPP2 GPAM PLPP1 GPD1 AKR1B1 ETHANOL FERMENTATION%SMPDB%SMP0002356 Ethanol Fermentation PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088358 Pentose Phosphate Pathway SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW000533 Sucrase-Isomaltase Deficiency UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GPI MGAM GBE1 PYGL HK2 GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 TIGECYCLINE ACTION PATHWAY%PATHWHIZ%PW000689 Tigecycline Action Pathway DE NOVO TRIACYLGLYCEROL BIOSYNTHESIS%SMPDB%SMP0015896 De Novo Triacylglycerol Biosynthesis AGPAT1 GPAM DGAT1 GPD1 LPIN1 SPECTINOMYCIN ACTION PATHWAY%PATHWHIZ%PW000356 Spectinomycin Action Pathway HOMOCYSTINURIA, CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%PATHWHIZ%PW000491 Homocystinuria, Cystathionine beta-Synthase Deficiency CBS;CBSL CTH HISTAPYRRODINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058732 Histapyrrodine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 PANTOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000591 Pantoprazole Metabolism Pathway ATP4B ATP4A VALSARTAN ACTION PATHWAY%SMPDB%SMP0000165 Valsartan Action Pathway ACE REN AGT GNG2 GNAQ GNB1 AGTR1 CARNOSINURIA, CARNOSINEMIA%SMPDB%SMP0000493 Carnosinuria, Carnosinemia AOC3 CNDP1 ABAT DPYS GAD1 ALDH6A1 UPB1 ALDH2 DPYD GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120837 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION%SMPDB%SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation DLST DHTKD1 ACMSD DLD ALDH8A1 BEVANTOLOL ACTION PATHWAY%PATHWHIZ%PW000645 Bevantolol Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B PROTEIN SYNTHESIS: TRYPTOPHAN%PATHWHIZ%PW120526 Protein Synthesis: Tryptophan RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 WARS1 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 PURINE METABOLISM%PATHWHIZ%PW000052 Purine Metabolism GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ITPA ADA INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000462 Inositol Phosphate Metabolism IPPK NUDT3 PPIP5K1 ISYNA1 IP6K1 INPP1 ITPK1 IPMK INPP4A MINPP1 IMPA1 ITPKA INPP5J INPP4B ENOXAPARIN ACTION PATHWAY%SMPDB%SMP0000272 Enoxaparin Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 SERPINC1 SACCHAROPINURIA HYPERLYSINEMIA II%SMPDB%SMP0000239 Saccharopinuria Hyperlysinemia II ECHS1 DLST ACAT1 DHTKD1 GCDH SLC25A2 AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH ALIMEMAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059689 Alimemazine H1-Antihistamine Action NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 MALONIC ACIDURIA%SMPDB%SMP0000198 Malonic Aciduria ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT ACADM MLYCD ACSS1 HIBCH LDHAL6B DLD BCKDHA ACSS3 AROMATASE DEFICIENCY%SMPDB%SMP0000565 Aromatase Deficiency SULT2B1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 STS SRD5A1 HSD17B1 HSD17B3 HSD3B1;HSD3B2 AKR1D1 CYP19A1 CYP17A1 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW121894 Glycogenosis, Type IC KIDNEY FUNCTION - DISTAL CONVOLUTED TUBULE%SMPDB%SMP0121012 Kidney Function - Distal Convoluted Tubule ATP1A1 SLC8A1 TRPV5 CLCNKA;CLCNKB SLC12A3 ATP1B3-1 AQP2 AQP3 REN FXYD2;FXYD6-FXYD2 ATP1B2 ATP4B ATP1B1 ATP1A4 ATP4A ATP1A3 ATP1A2 ARGININOSUCCINIC ACIDURIA%PATHWHIZ%PW000184 Argininosuccinic Aciduria ARG1 GOT2-1 ASS1 GPT SLC1A4 SLC25A15 CPS1 SLC1A5 SLC25A12 ASL OTC GLS2 GLUD1;GLUD2 FOSINOPRIL METABOLISM PATHWAY%SMPDB%SMP0000594 Fosinopril Metabolism Pathway ACE PINDOLOL ACTION PATHWAY%PATHWHIZ%PW000374 Pindolol Action Pathway SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells SUCCINATE SIGNALLING DURING INFLAMMATION%SMPDB%SMP0084634 Succinate Signalling During Inflammation MAPK3 NFKB1 SUCNR1 CREB1 IKBKB IKBKG PLCB1 MAPK11 PTGS1 PRKCA MAPK1 CHUK NOS3 TAMOXIFEN ACTION PATHWAY%SMPDB%SMP0000471 Tamoxifen Action Pathway CYP2D6;LOC107987479;LOC107987478-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 FMO1 FMO3 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ESR1 CYP2B6 MITOCHONDRIAL DNA DEPLETION SYNDROME-3%SMPDB%SMP0000536 Mitochondrial DNA Depletion Syndrome-3 GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ITPA ADA D4-GDI SIGNALING PATHWAY%SMPDB%SMP0066935 D4-GDI Signaling Pathway PRF1 ARHGAP5 ARHGAP32 CASP8 CASP1 CASP10 CASP3 ARHGDIB CYCS-1 JUN APAF1 PARP1 GZMH;GZMB-1 CASP9 FRUCTOSURIA%PATHWHIZ%PW121881 Fructosuria ARACHIDONIC ACID METABOLISM%SMPDB%SMP0000075 Arachidonic Acid Metabolism PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES 5-OXOPROLINURIA%PATHWHIZ%PW000074 5-Oxoprolinuria GSS GSR GCLC CASP7 GGCT GCLM GGT6 GPX1 GSTO2 ANPEP OPLAH ETORICOXIB ACTION PATHWAY%SMPDB%SMP0000695 Etoricoxib Action Pathway PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PROTEIN SYNTHESIS: ASPARAGINE%SMPDB%SMP0111854 Protein Synthesis: Asparagine NARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW121892 Fanconi-Bickel Syndrome INTRACELLULAR SIGNALLING THROUGH HISTAMINE H2 RECEPTOR AND HISTAMINE%PATHWHIZ%PW000449 Intracellular Signalling Through Histamine H2 Receptor and Histamine ADCY2 PRKACB-1 GNGT1 CREB1 PPP1CA GNAS-1 GNB1 HRH2 DESMOSTEROLOSIS%PATHWHIZ%PW000097 Desmosterolosis ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA LSS LYSOPHOSPHATIDIC ACID LPA3 SIGNALLING%SMPDB%SMP0063755 Lysophosphatidic Acid LPA3 Signalling GNAS-1 LPAR3 GNG2 GNB1 ITPR1 AKT1 ADCY1 PLCB1 THE ONCOGENIC ACTION OF 2-HYDROXYGLUTARATE%SMPDB%SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB GLS2 CS PC SUCLG2 ACO1 SUCLG1 ACO2 DLD GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%SMPDB%SMP0121313 Glycerol Metabolism V (Glycerophosphoserine) TUMOR SUPPRESSOR ACTIVITY OF SMARCB1%WIKIPATHWAYS_20260510%WP4204%HOMO SAPIENS Tumor suppressor activity of SMARCB1 DPF1 DPF2 DPF3 H3-3A SUZ12 SMARCE1 SMARCC1 SMARCC2 ACTL6B EED CDKN2A PTCH1 ACTL6A ARID1A ARID1B SMARCA4 CDK6 SMO CDK4 EZH2 RB1 SMARCD1 SMARCD2 SMARCB1 SMARCD3 GLI1 GLI3 GLI2 GLI4 RBBP4 MAPK AND NFKB SIGNALING INHIBITED BY YERSINIA YOPJ%WIKIPATHWAYS_20260510%WP3849%HOMO SAPIENS MAPK and NFkB signaling inhibited by Yersinia YopJ IKBKB NFKBIA MAP3K1 RRAS CHUK TRAF6 MAPK1 IKBKG RAF1 MAP3K14 NFKB1 MAP2K6 CALCIUM REGULATION IN CARDIAC CELLS%WIKIPATHWAYS_20260510%WP536%HOMO SAPIENS Calcium regulation in cardiac cells CHRM2 CHRM3 CHRM1 CALR-1 CHRM4 CHRM5 SLC8A1 RGS4 RGS5 RGS2 GJA1 RGS3 GJA3 RGS1 GJA5 GJA4 GJA9 GJA8 RGS9 RGS6 RGS7 PRKCG PRKCH PRKCB PRKCE PRKCD PRKCA ATP1B2 ATP1B1 GNAS-1 CACNB1 CACNB3 ADCY9 PRKAR1B STIM2 PRKAR1A ORAI1 PRKCQ PRKD1 GNAZ CACNA1B ITPR1 CACNA1A ITPR2 CACNA1D ADRB1 ITPR3 CACNA1C ADRB2 PRKCZ CACNA1E GJC1 GJC2 GRK5 PRKAR2B GRK4 PRKAR2A GRK6 SFN CACNA1S GNG13 GNAO1 PKIB GJB2 GJB1 GJB4 GJB3 GNAQ PKIA GJB6 GNB2 GJB5 GNB1 GNB4 GNB3 GNB5 PKIG CALM1 CALM2 YWHAE RYR1 RYR2 YWHAB ATP2A3 ATP2A2 ADRA1D ARRB1 ARRB2 ADRA1B ADRA1A RYR3 GNGT1 PRKACA-1 YWHAQ ANXA6 YWHAG YWHAH YWHAZ GJD2 PLCB3 ADRB3 CASQ2 CASQ1 RGS18 CAMK2B RGS17 CAMK2D RGS19 RGS14 RGS16 CAMK2A ADCY4 ATP1A4 GNAI3 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 GNAI1 ADCY6 GNAI2 ADCY5 PRKACB-1 GNG2 GNG5 GNG4 GNA11 RGS20 GNG8 CAMK2G KCNJ3 KCNJ5 KCNB1 ATP1B3-1 ATP2B3 ATP2B2 FXYD2;FXYD6-FXYD2 ATP2B1 CALM3;CALM1 FKBP1A SLC8A3 CAMK4 RGS10 CAMK1 RGS11 SARS COV 2 MITOCHONDRIAL CHRONIC OXIDATIVE STRESS AND ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260510%WP5183%HOMO SAPIENS SARS CoV 2 mitochondrial chronic oxidative stress and endothelial dysfunction ACE2 MAVS IL6 STING1 TRAF3 NDUFAF2 TERF2IP REN NDUFAF1 NOX1 TRAF6 NFKB1 NLRX1 PHB ECSIT TNF RPS6KA1 NLRP3 TOMM70 ACE ACAD9 IL18 SIRT6 BCS1L TERF2 AGT ETHYLMALONIC ENCEPHALOPATHY%WIKIPATHWAYS_20260510%WP5030%HOMO SAPIENS Ethylmalonic encephalopathy TST ETHE1 SUOX CORTICOTROPIN RELEASING HORMONE SIGNALING%WIKIPATHWAYS_20260510%WP2355%HOMO SAPIENS Corticotropin releasing hormone signaling IL2 FOSL2 POMC FOSL1 NR4A2 NR4A1 HSD3B1;HSD3B2 STAR CYP11B1;CYP11B2 SP1 BCL2 CTNNB1 FOSB TCF4 CAMK2A NFKBIA GNAI1 GNAI2 MAPK1 RAF1 NFKB1 GNA11 GJA1 PRKCB PRKCD PRKCA IL18 GNAS-1 PRKCQ GNAZ GSK3B CXCL8 ECE1 ELK1 CASP9 CRHBP TRIM28 CASP3 AKT1 KRT16;KRT14 JUNB MAP3K5 NCOA2 GRK6 HSP90AA1 PRKCI PARP1 KRT1 GNAO1 FOS RHOA ERN1 CREB1 CYP21A2 CRH GNAQ SULT2A1-4 TLR4 IVL GNB2 RAPGEF3 PRKAA2 GNB1 CRHR1 ACACA GNB3 RELA GNB5 CACNA1H CRHR2 RAP1B MAPK9 GRK3 MAPK8 MAP2K2;MAP2K1 CYP11A1 PLCG2 PLCG1 ARRB1 MAPK3 ARRB2 TFAP2A TGFB1 JUND JUP NOS3 BRAF MAPK14 TBX19 PTK2 HEMOGLOBIN SWITCHING EMBRYONIC FETAL AND ADULT%WIKIPATHWAYS_20260510%WP5605%HOMO SAPIENS Hemoglobin switching embryonic fetal and adult LDB1 TAL1 LMO2 HBD;HBB GATA1 HBA2;HBA1 HBG2;HBG1 HBZ ESTROGEN SIGNALING%WIKIPATHWAYS_20260510%WP712%HOMO SAPIENS Estrogen signaling CREB1 GNB1 SP1 BCL2 MAPK9 ELK1 MAP2K2;MAP2K1 IKBKB AKT1 JUN ESR1 CHUK PIK3CA GPER1 MAPK1 GNGT1 IKBKG BRAF PRKACA-1 MAPK14 GNAS-1 FOS NFKB1 GENES RELATED TO PRIMARY CILIUM DEVELOPMENT BASED ON CRISPR %WIKIPATHWAYS_20260510%WP4536%HOMO SAPIENS Genes related to primary cilium development based on CRISPR DYNC2I2 DYNC2I1 TRAF3IP1 CEP19 IFT172 CEP120 TXNDC15 CDK20 TRAPPC11 KIFAP3 CEP97 DYNC2H1 ARMC9 IFT80 RPGRIP1L LZTFL1 IFT88 IFT81 TTC30A;TTC30B WDPCP CEP20 TEDC1 CEP104 TEDC2 ARL6 ARL3 FBF1 TTBK2 DYNC2LI1 KIF3B KIF3A TTC21B INPP5E CEP192 CEP76 PIBF1 BBS2 BBS1 IFT122 CPLANE1 FUZ CPLANE2 TMEM231 IFT20 TMEM17 SASS6 MKS1 CEP83 IFT27 CIBAR1 TTC26 TTC23 C2CD3 CBY1 EFCAB7 HSPB11 IFT52 TCTN3 TCTN2 TMEM107 TCTN1 BBS9 BBS7 IFT57 CC2D2A BBS5 BBS4 MKKS DYNLT1 IFT140 CEP295 WDR35 BBS10 IFT43 EVC BBS12 TMEM216 IFT46 CILK1 DYNLT2B TULP3 KATNB1 TUBD1 IFT74 ARL13B TMEM67 RAB23 KIAA0753 OFD1-1 EVC2 WDR19 SCLT1 TUBE1 RABL2A;RABL2B MIB1 TTC8 CEP162 B9D1 CEP43 CLUAP1 CEP44 HALLMARK OF CANCER SUSTAINING PROLIFERATIVE SIGNALING%WIKIPATHWAYS_20260510%WP5475%HOMO SAPIENS Hallmark of cancer sustaining proliferative signaling FLT1 FLT3 FLT4 PTEN PIK3CD PIK3CB PIK3CG IGF1R RPTOR DEPTOR CCND1 SALL4 CTNNB1 MYC AKT2 AKT3 MLST8 KDR JAK2 IL6R HRAS IKBKB PDGFRB PDGFRA NFKBIA KSR1 JUN TSC2 CHUK TSC1 PIK3CA FOXO1-1 AXIN2 MAPK1 IKBKG TTI1 GAREM2 RAF1 PYGO1 AKT1S1 NFKB1 KIT RARA ULK2 SOS1 SOS2 MET TP53 TELO2 EPHA2 PPARD CSF1R SRC MDM2-2 LEF1 LRP5 RETN EGFR LRP6 WNT1 RUNX1T1 NTRK1 NGFR NTRK2 CSNK1A1 INSR ZBTB16 FZD6 STAT3 MTOR PML BCL9 APC RHEB REL KRAS IL6 GRB2 TEK FGFR4 NFKBIE FGFR3 FGFR2 SHC1-1 FGFR1 GSK3B ELK1 AKT1 FOS RELA MAP2K2;MAP2K1 MAPK3 JUP BRAF CDKN1A PTK2 SICKLE CELL DISEASE%WIKIPATHWAYS_20260510%WP5604%HOMO SAPIENS Sickle cell disease HBD;HBB TLR4 HBA2;HBA1 IL1B IL18 MELANOMA%WIKIPATHWAYS_20260510%WP4685%HOMO SAPIENS Melanoma PTEN PIK3CD PIK3CB CCND1 CDKN2A AKT2 AKT3 KDR CDK6 CDK4 HRAS PIK3CA MAPK1 RAF1 KIT SOS1 SOS2 TP53 MDM2-2 CALM3;CALM1 KRAS GRB2 CALML6 ARAF CALML3 STK19 CALML4 GRM3 PREX2 CDH1 RAC1 POLK AKT1 EXOC7 MITF RHOC RHOB DDB2 CTTN PDE5A VCL SHC2 PIK3R3 RHOA PIK3R2 PIK3R1 GRIN2A NRAS PAK1 ERBB4 E2F1 E2F2 E2F3 BAK1 GADD45B BAD GADD45A PTPN11 GADD45G CALM1 NF1 CALM2 BAX MAP2K2;MAP2K1 RB1 MAPK3 BRAF CDKN1A MIRNAS INVOLVED IN DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260510%WP1545%HOMO SAPIENS miRNAs involved in DNA damage response CREB1 E2F1 TP53 CCND1 MYC CDKN1B CDK6 CDC25A RAD52 CCND3 CCNE1 ABL1 ATM CDKN1A CELL CYCLE%WIKIPATHWAYS_20260510%WP179%HOMO SAPIENS Cell cycle CHEK1 EP300 SKP2 SKP1 ANAPC7 CDC25C CDC25B RBX1 CCNE2 ANAPC4 ANAPC5 CDKN2A MAD1L1 ANAPC1 ANAPC2 E2F4-1 ANAPC13 PRKDC CDK6 CUL1 PKMYT1 CDK4 ANAPC10 ANAPC11 ORC5 CCNB3 ORC4 CCNB2 CCNB1 ORC6 ORC1 ORC3 RAD21 ORC2 SMAD2;SMAD3 ZBTB17 TGFB2 SMAD4 TGFB3 PLK1 CDC7 CDC6 STAG1 CDK7 STAG2 CDK2 CDC16 CDK1 ATR CDKN1C MCM7 PTTG1;PTTG2 CCNA2-1 SMC1A SMC1B RBL2 CCNA1 RBL1 DBF4 TFDP1 ESPL1 TFDP2 MCM3 MCM4 MCM5 MCM6 MCM2 HDAC2 PCNA HDAC1 TTK FZR1 CDC45 BUB3 E2F5 BUB1 CDKN2D CDKN2B CDKN2C MAD2L2 WEE1 WEE2 SFN YWHAE YWHAB YWHAQ CDKN1A YWHAG YWHAH YWHAZ CCND1 MYC TP53 MDM2-2 GSK3B E2F1 E2F2 E2F3 GADD45B GADD45A GADD45G CDKN1B CDC25A CCND3 CCNE1 ABL1 RB1 ATM CCNH SMC3 TGFB1 CDC14A CDC14B CDC20 CDC23 CCND2 CHEK2 CDC27 RETINOBLASTOMA GENE IN CANCER%WIKIPATHWAYS_20260510%WP2446%HOMO SAPIENS Retinoblastoma gene in cancer CHEK1 SKP2 CDC25B CCNE2 CCND1 MYC PRKDC CDK6 CDK4 CCNB2 CCNB1 ORC1 RAF1 TP53 CDC7 CDK2 MDM2-2 CDK1 MCM7 CCNA2-1 SMC1A TFDP1 TFDP2 MCM3 MCM4 MCM6 PCNA HDAC1 TTK CDC45 WEE1 TOP2A SUV39H1 FAF1 HMGB2 SMC2 SIN3A STMN1 POLE RFC5 KIF4B;KIF4A RFC3 RFC4 PRMT2 H2AZ2;H2AZ1 DHFR2;DHFR DCK SAP30 MSH6 RBP1 RRM2-1 DNMT1 PRIM1 TYMS E2F1 POLD3 E2F2 NPAT E2F3 HLTF HMGB1-1 RBBP7 BARD1 PLK4 CDT1 RRM1 RPA1 CDKN1B RPA2 CDC25A SMARCA2 FANCG CCND3 MAPK13 CCNE1 ANLN ABL1 POLA1 RB1 RABIF RPA3 SMC3 POLE2 CCDC6 ZNF655 CDKN1A RBBP4 PROLINE AND HYDROXYPROLINE PATHWAYS%WIKIPATHWAYS_20260510%WP5026%HOMO SAPIENS Proline and hydroxyproline pathways ALDH4A1 OAT PYCR1 PEPD PRODH;LOC102724788 OCTADECANOID FORMATION FROM LINOLEIC ACID%WIKIPATHWAYS_20260510%WP5324%HOMO SAPIENS Octadecanoid formation from linoleic acid GPX4 CYP2C9;CYP2C19 CYP1A2 ALOX15 EPHX3 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ALOX12B ALOXE3 PTGS2-2 PTGS1 MIRNA BIOGENESIS%WIKIPATHWAYS_20260510%WP2338%HOMO SAPIENS miRNA biogenesis XPO5 DGCR8 DROSHA DICER1 TARBP2 RAN CYCLIN DEPENDENT KINASE 4 6 INHIBITORS IN BREAST CANCER%WIKIPATHWAYS_20260510%WP5497%HOMO SAPIENS Cyclin dependent kinase 4 6 inhibitors in breast cancer KRAS PIK3CD PIK3CB PIK3CG IGF1R RPTOR CCND1 AKT2 AKT3 IRS1 CDK6 PIK3R4 PIK3C2G CDK4 PIK3C2A HRAS CYP19A1 PIK3R6 AKT1 PIK3C2B PIK3R5 ESR1 INS;INS-IGF2 PIK3CA ERBB2 MAPK1 RAF1 PIK3R3 PIK3R2 PIK3R1 NRAS CDK2 EGFR CDKN1B CCNE1 MAPK3 MTOR CDKN1A MICRORNA NETWORK ASSOCIATED WITH CHRONIC LYMPHOCYTIC LEUKEMIA%WIKIPATHWAYS_20260510%WP4399%HOMO SAPIENS MicroRNA network associated with chronic lymphocytic leukemia TP53 ZAP70 BCL2 MCL1 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES APOPTOSIS%WIKIPATHWAYS_20260510%WP4864%HOMO SAPIENS Host pathogen interaction of human coronaviruses apoptosis MAPK11 CASP7 CASP8 BCL2L11 FADD BID BCL2L1 BAD BCL2 BAX CASP9 MAPK13 CASP3 TNF AKT1 MCL1 APAF1 FASLG MAPK14 MAPK12 BBC3 IL5 SIGNALING%WIKIPATHWAYS_20260510%WP127%HOMO SAPIENS IL5 signaling IL2 KRAS GRB2 PIK3CG SHC1-1 GSK3B ELK1 JAK2 AKT1 JUN MAPK1 RAF1 PIK3R2 PIK3R1 SOS1 GSK3A IL5RA CSF2RB FOXO3 SPRED1 JAK1 PTPN11 STAT5A LYN STAT5B SYK STAT1 MAP2K2;MAP2K1 RPS6 RPS6KB1 RPS6KB2 BTK RPS6KA1 MAPK3 MAPT STAT3 PPAR ALPHA PATHWAY%WIKIPATHWAYS_20260510%WP2878%HOMO SAPIENS PPAR alpha pathway APOA5 CYP8B1 CYP7A1 FABP1 RXRA CPT2 SCP2 ACADM PPARA PLTP CCND1 MYC CDK1 CDK4 SLC27A1 CPT1A EHHADH-1 APOA2 ACAA1-1 NR1H3 APOA1 APOC3 KLK15 ERBB SIGNALING%WIKIPATHWAYS_20260510%WP673%HOMO SAPIENS ErbB signaling PIK3CD PIK3CB CAMK2B CCND1 CAMK2D MYC AKT2 AKT3 CAMK2A HRAS JUN PIK3CA FOXO1-1 ERBB2 MAPK1 RAF1 SOS1 CAMK2G SOS2 BCL2L11 TP53 SRC MDM2-2 STAT5A EGFR STAT5B RPS6KB1 RPS6KB2 PRKCG PRKCB PRKCA MTOR KRAS GRB2 SHC1-1 BUB1B-PAK6;PAK6 CBLB ARAF AREG GSK3B CRKL NCK2 NCK1 ELK1 MAP2K4 PDPK1 GAB1 NRG1 NRG2 AKT1 EREG BTC NRG3 NRG4 CRK HBEGF SHC4 SHC3 SHC2 TGFA PIK3R3 CBL PIK3R2 ERBB3 PIK3R1 EIF4EBP1 ABL2 NRAS MAP2K7 PAK1 PAK3 ERBB4 PAK2 PAK5 PAK4 EGF MAPK10 BAD MAPK9 CDKN1B MAPK8 MAP2K2;MAP2K1 PLCG2 ABL1 MAPK3 BRAF CDKN1A PTK2 HAIR FOLLICLE DEVELOPMENT ORGANOGENESIS STAGE 2 OF 3%WIKIPATHWAYS_20260510%WP2839%HOMO SAPIENS Hair follicle development organogenesis stage 2 of 3 FGFR2 CCND1 PTCH1 CTNNB1 MYC SMO CDH1 PDGFRA NFKB1 GJB6 ITGB1 LAMA5 EDA FOXI3 LEF1 LRP5 PDGFA FGF1 SHH NCAM1 TP63 FZD1 WNT5A INHBA GTPBP4 RUNX2 BMP4 EDAR SNAI1 GLI1 GLI2 CCND2 FATTY ACID OMEGA OXIDATION%WIKIPATHWAYS_20260510%WP206%HOMO SAPIENS Fatty acid omega oxidation CYP1A1 CYP2E1 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ADH4 CYP2D6;LOC107987479;LOC107987478-1 ADH1C;ADH1B;ADH1A CYP2A13;CYP2A6;CYP2A7-1 ALDH2 ALDH1A1 HEAD AND NECK SQUAMOUS CELL CARCINOMA%WIKIPATHWAYS_20260510%WP4674%HOMO SAPIENS Head and neck squamous cell carcinoma MAML1 PTEN KEAP1 STK11 PIK3CB SESN1 PIK3CG SESN2 IGF1R TGFBR2 RPTOR DDIT4 NUMB CCND1 IRF6 CDKN2A AJUBA CTNNB1 BIRC2 AKT2 NOTCH2 AKT3 PRKAA1 MLST8 NOTCH1 CUL3 CDK6 MAPKAP1 TERT CDK4 HRAS RICTOR CSMD3 EIF4E VEGFA TSC2 PIK3R5 NFKB2 TSC1 PIK3CA FAT1 ERBB2 LTBR NFE2L2 NFKB1 CASP8 SMAD4 FADD TP53 FKBP1A EGFR RPS6 RPS6KB2 MTOR RHEB REL KRAS TRAF3 FGFR3 FGFR1 PDPK1 AKT1 PIK3R2 PIK3R1 EIF4EBP1 NRAS E2F1 PRKAA2 RELA TP63 RB1 CDKN1A BETA GLOBIN GENE EXPRESSION REGULATION%WIKIPATHWAYS_20260510%WP5606%HOMO SAPIENS Beta globin gene expression regulation HDAC2 GATAD2B KLF1 HDAC1 MYB DNMT1 MTA2 ZFPM1 ZBTB7A PPARGC1A HBG2;HBG1 LDB1 TAL1 LMO2 HBD;HBB GATA1 KDM1A BCL11A CHD3 NR2C2 NR2C1 GNAQ PATHWAYS IN PORT WINE STAIN%WIKIPATHWAYS_20260510%WP5437%HOMO SAPIENS GNAQ pathways in port wine stain MAP2K7 GNAQ MAP2K3 TRIO AMOT YAP1-1 MAP2K5 PDK1 MAP2K4 MAP2K2;MAP2K1 RAC1 AKT1 MAPK3 PIK3CA MAPK1 MTOR RAF1 NFKB1 RHOA MAP2K6 IL9 SIGNALING%WIKIPATHWAYS_20260510%WP22%HOMO SAPIENS IL9 signaling PIK3R1 GRB2 JAK1 STAT5A IL2RG CDK9 STAT5B IL9 JAK3 STAT1 IL9R MAP2K2;MAP2K1 MAPK3 STAT3 MAPK1 PIK3R2 GLYCINE METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260510%WP5028%HOMO SAPIENS Glycine metabolism including IMDs ISCU LIPT2 LIPT1 GLDC GLRX5 SHMT1 GCSH-3 AMT IBA57 HSCB LIAS NFU1 BOLA3 PNPO DLD NIPBL ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260510%WP5119%HOMO SAPIENS NIPBL role in DNA damage Cornelia de Lange syndrome CBX3-1 MDC1 NIPBL RNF168-1 RNF8 ATM ATR REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20260510%WP51%HOMO SAPIENS Regulation of actin cytoskeleton RRAS PIK3CA MAPK1 RAF1 CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 CYFIP2 NCKAP1 WASF1-1 FGF2 ARHGAP35 FGF3 MYLK ACTG1 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 CFL2 CFL1 PIP4K2A PIP4K2B PIP4K2C ACTN1 F2R MYL1 MYL3 PFN1 EZR PXN PDGFB IQGAP1 SLC9A1 FGF20 PIP5K1A PIP5K1B PIP5K1C CD14 FGF23 MYH10 FGF22 FGF21 RDX FN1 RASSF7 MSN ARPC5 SSH2 SSH3 SSH1 FGF17 VIL1 FGF16 DIAPH1 FGF14 DIAPH3 FGF19 ACTB-1 FGF18 FGF13 FGF12 FGF11 FGF10 PIP5KL1 BDKRB2 BDKRB1 PIK3CD RAC3 PIK3CB GIT1 PIK3CG APC2 PPP1R12A ITGA1 RRAS2 F2 VAV1 ENAH MRAS ARHGEF4 ARHGEF1 PIK3C3 PIK3R4 ARHGEF7 PIK3C2G DOCK1 PIK3C2A ARHGEF6 PDGFRB ROCK1 PDGFRA ROCK2 PIK3C2B WAS PIK3R5 FGD1 GNA13 CDC42 GNA12 CSK MAPK6 WASF2 MAPK4 GSN LIMK1 BAIAP2 SOS1 MOS SOS2 ABI2 BCAR1 EGFR APC KRAS FGFR4 FGFR3 FGFR2 FGFR1 BUB1B-PAK6;PAK6 RAC1 CRK VCL PIK3R3 PIK3R2 RHOA PIK3R1 NRAS PAK1 PAK3 PAK2 PAK5 PAK4 EGF PDGFA FGF1 MAP2K2;MAP2K1 MAPK3 BRAF PTK2 SHANK3 PATHWAY INVOLVED IN PHELAN MCDERMID SYNDROME%WIKIPATHWAYS_20260510%WP5566%HOMO SAPIENS SHANK3 pathway involved in Phelan McDermid syndrome ITPR1 CAMK2A ARHGEF7 HRAS CDC42 CTTN BAIAP2 PAK1 GRIA1 GRIA2 CTNND2 GRM1 ITGB1 ARHGAP44 GRM5 RAP1A SYNGAP1 SHARPIN DLGAP1 MAP3K7 SPTAN1 LZTS3 DBNL HOMER1 GRIN2B GRIN1 DLG4 ABI1 ADGRL1 TAB2 SHANK3 ACTB-1 HCN1 FBXL10 ENHANCEMENT OF MAP ERK SIGNALING IN DIFFUSE LARGE B CELL LYMPHOMA%WIKIPATHWAYS_20260510%WP4553%HOMO SAPIENS FBXL10 enhancement of MAP ERK signaling in diffuse large B cell lymphoma RNF2 H2AJ BCL6 PCGF1 H3-3A SUZ12 BCOR H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AB2;H2AB3;H2AB1 EED EZH2 MAPK3 MAPK1 KDM2B H2AZ2;H2AZ1 MACROH2A2 MACROH2A1 DUSP6 PERTURBED THYROID HORMONE HOMEOSTASIS LEADING TO DEVELOPMENTAL NEUROTOXICITY%WIKIPATHWAYS_20260510%WP5517%HOMO SAPIENS Perturbed thyroid hormone homeostasis leading to developmental neurotoxicity SLCO1C1 SLC7A5 SLC7A8 SLCO3A1 SLCO4A1 SLCO1A2 SLC16A10 SLC16A2 TH17 CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260510%WP5130%HOMO SAPIENS Th17 cell differentiation pathway IL2 JAK2 IL6R IKBKB NFKBIA JUN ZAP70 MAPK1 NFKB1 SMAD2;SMAD3 RARA JAK1 STAT5A STAT1 STAT3 MTOR IL6 RXRA PRKCQ IL1B IL21 IL22 IL23R RORC TGFBR1-1 CD3G RORA IL27 AHR CD3E CD3D IL27RA HSP90AA1 PPP3CA IL4R IFNGR1 FOS TYK2 FOXP3 RUNX1 IFNG IL23A LCK IRF4 CRY1 CLOCK GATA3 HIF1A ARNTL SOCS3 HLA-DMA NFIL3 TBX21 IL21R STAT6 NFATC1 MAPK8 NR1D1 IL4 PER1 CD4 PLCG1 IL2RA IL17F CD247 TGFB1 LAT IL17A MAPK14 LINOLEIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260510%WP5137%HOMO SAPIENS Linoleic acid oxylipin metabolism ALOX15 ALOX5 EPHX2 MFAP5 EFFECT ON PERMEABILITY AND MOTILITY OF ENDOTHELIAL CELLS VIA CYTOSKELETON REARRANGEMENT%WIKIPATHWAYS_20260510%WP4560%HOMO SAPIENS MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement MYL2 CREB1 ITGAV PRKCQ ITPR1 MYLK PLCG1 JUN MAPK3 ACTN1 MAPK1 ITGB3 VCL LPP TJP1 PXN PTK2 MFAP5 T CELL RECEPTOR AND CO STIMULATORY SIGNALING%WIKIPATHWAYS_20260510%WP2583%HOMO SAPIENS T cell receptor and co stimulatory signaling IL2 ITK DYRK2 PTEN RASGRP1 CTLA4 FYN DYRK1A NFATC2 CD8A RASA1 CD8B;CD8B2 CD28 GSK3B PTPN6 PDCD1 AKT1 NFKBIA ZAP70 PPP3CA NFKB1 LCK GSK3A PDK1 CALM1 PLCG1 CSNK1A1 PRKCA HEPATITIS C AND HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260510%WP3646%HOMO SAPIENS Hepatitis C and hepatocellular carcinoma PTGS2-2 CCND1 MYC BRCA1 UCHL1 MMP1 IL6R MYOF HNF1A VAV2 COL4A2 BIRC5 JUN VEGFA CD44 BIRC3 CXCR1 FRZB PODXL NOS2 FASLG NFKB1 SMAD2;SMAD3 CASP7 SOS1 SMAD4 TP53 BCL2L1 JAK1 LEF1 STAT3 IL6 GRB2 CXCL8 CASP9 TGFBR1-1 RAC1 CASP3 AKT1 CTTN RRM2-1 E2F2 HIF1A PTPN11 MAPK8 MAPK3 TGFB1 MAPK14 CDKN1A EFFECT OF OMEGA 3 PUFA ON HUNTINGTON 39 S DISEASE PATHWAYS%WIKIPATHWAYS_20260510%WP5470%HOMO SAPIENS Effect of omega 3 PUFA on Huntington 39 s disease pathways SP1 BCL2 PRKAA1 RICTOR IKBKB EIF4E PIK3CA MAPK1 RAF1 RAB3A CYP46A1 NFKB1 HMGCS1-1 RPS6KA5 KIF5A PRKAB2 PRKAB1 GABRG1 ABCG4 ABCG1 PPARGC1A NEUROD1 MBP APOE ABCA1 BDNF AHI1 MAP3K10 DHCR7 GABRB3 GABRB2 GABRB1 PRKAG1 PRKAG2 PRKAG3 OPA1 GABRG3;GABRG2 HMGCS2 SREBF2 HAP1 HTT PRR5L HMGCR CKB GABRE GABRD HDAC2 SLC12A2 GABRQ HDAC1 GABRA2 GABRA1 GABRP SLC12A5 GABRA6 GABRA5 BNIP3 ITPR1 NR1H2 GABRA4 CYP51A1 GABRA3 REST RAB3GAP1 SIN3A PTEN PIK3CD PIK3CB PIK3CG RPTOR DEPTOR AKT2 AKT3 MLST8 PIK3R4 PIK3C2G PIK3C2A HRAS PIK3R6 PIK3C2B TSC2 PIK3R5 TSC1 AKT1S1 CASP7 CASP8 BCL2L11 BID BCL2L1 GRM1 EGFR RPS6KB1 NTRK2 MTOR RHEB IL6 IL1B ELK1 MAP2K4 CASP3 AKT1 PIK3R3 PIK3R2 PIK3R1 EIF4EBP1 CREB1 MAP2K7 EGF PRKAA2 MAPK10 BAD MAPK9 BAX MAPK8 MAP2K2;MAP2K1 MAPK3 SEROTONIN HTR1 GROUP AND FOS PATHWAY%WIKIPATHWAYS_20260510%WP722%HOMO SAPIENS Serotonin HTR1 group and FOS pathway RASGRP1 ITPR1 SRF RASGRF1 ELK1 GNAI3 HTR2A JAK2 PDPK1 ELK4 HTR1E HTR1F HTR1D MAP3K1 HTR1A GNAI1 HTR1B MAPKAPK3 PIK3CA GNAI2 MAPKAPK2 MAPK1 GNAO1 FOS MAP2K6 RHOA RPS6KA5 CREB1 GNAQ MAP2K3 RAP1A MAP2K2;MAP2K1 MAPK3 STAT3 BRAF MAPK14 ARYL HYDROCARBON RECEPTOR PATHWAY%WIKIPATHWAYS_20260510%WP2873%HOMO SAPIENS Aryl hydrocarbon receptor pathway IL2 CYP1A1 EP300 CYP1A2 SLC7A5 IL1B MYOF POLK JUN AHR JUNB PTGES3-1 HSP90AA1 NFE2L2 MGST1 CYP1B1 IL12B HES1 IL12A CAP2 IGFBP1 IFNG NCOA1 NQO1 SERPINB2 UGT1A1;UGT1A6 AIP ARNT ALDH3A1 CDC37 SRC AHRR GSTA3;GSTA5;GSTA1;GSTA2 CES3 IL17B EGFR BAX CDKN1B TNF TGFB1 JUND DOPAMINE METABOLISM%WIKIPATHWAYS_20260510%WP2436%HOMO SAPIENS Dopamine metabolism TH MAOA PPP2CB;PPP2CA NQO1 TYR COMT SOD1 PRKACB-1 PRKACA-1 DDC MAOB BMP2 WNT4 FOXO1 PATHWAY IN PRIMARY ENDOMETRIAL STROMAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260510%WP3876%HOMO SAPIENS BMP2 WNT4 FOXO1 pathway in primary endometrial stromal cell differentiation BCL2L11 CTNNB1 SMAD1 LEFTY2;LEFTY1 SMAD9 FOXO1-1 DKK1 SMAD5 DCN SFRP1 BMP2 SST WNT4 CANCER IMMUNOTHERAPY BY PD 1 BLOCKADE%WIKIPATHWAYS_20260510%WP4585%HOMO SAPIENS Cancer immunotherapy by PD 1 blockade NFAT5 CD274 IFNG NFATC3 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 LCK PDCD1LG2 NFATC4 BATF HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E NFATC2 CD8A CD8B;CD8B2 PTPN11 PDCD1 NFATC1 CD3G JUN CD3E CD3D STAT3 ZAP70 NFKB1 PEROXISOMAL BETA OXIDATION OF TETRACOSANOYL COA%WIKIPATHWAYS_20260510%WP1941%HOMO SAPIENS Peroxisomal beta oxidation of tetracosanoyl CoA SCP2 ACOX1 HSD17B4 ACAA1-1 GASTRIN SIGNALING%WIKIPATHWAYS_20260510%WP4659%HOMO SAPIENS Gastrin signaling IL2 FYN SP1 CDKN2A CTNNB1 BIRC2 TCF4 IKBKB NFKBIA JUN BIRC5 VEGFA CD44 CHUK PIK3CA BIRC3 MAPK1 RAF1 NFKB1 PRKCH PRKCE PRKCD PRKCA PRKCQ PRKD1 PXN SLC9A1 GNAQ SERPINB2 ARRB1 ARRB2 PRKACA-1 BMP2 CDKN1A PTGS2-2 ATF2 CCND1 SERPINE1 CLDN1 MYC KAT5 MEF2C MEF2B;BORCS8-MEF2B IRS1 SLC9A3 PRKD2 JAK2 ARHGEF28 EGR1 HRAS YES1 ROCK1 JAG1 MAP3K11 ELAVL1 GAST MMP7 FOXO1-1 CDC42 ANXA2 RHOD CCKBR PPARG HDC KIT HDAC7 MEF2D CHGA SOS1 KLF4 LAMTOR3 BCAR1 BCL2L1 FOXO3 SRC EGFR RPS6 RPS6KB1 STAT3 MTOR KRAS GRB2 SHC1-1 GSK3B CXCL8 ELK1 CDH1 RAC1 CASP3 AKT1 RHOB CRK PIK3R3 FOS PIK3R2 RHOA PIK3R1 EIF4EBP1 CREB1 PAK1 ITGB1 BAD RELA PTPN11 MAPK9 CDKN1B MAPK8 MAP2K2;MAP2K1 PLCG1 MAPK3 MAPK14 TJP1 PTK2 COMPLEMENT SYSTEM IN NEURONAL DEVELOPMENT AND PLASTICITY%WIKIPATHWAYS_20260510%WP5090%HOMO SAPIENS Complement system in neuronal development and plasticity ITGAV TGFB2 TGFB3 MBP PRKCZ APAF1 FASLG CASP7 CASP8 PATJ PROS1 BID C4BPA C4BPB CLU C3AR1 LOC110384692;C4A;C4B_2;C4B FCN2;FCN1 ATP11C SCRIB ATP11A PARD3 TYRO3 SERPING1 MASP2 MASP1 CFB LLGL2 CFD C5AR2 CFI C5AR1 HTRA2 CFP C2 VTN C5 C6 C7 C9 MARK3 MARK2 MARK1 ATP8B3 ATP8B2 ATP8B1 CFH-3 ITGAM ITGB2 C8B C8A CX3CL1 C8G CASP10 ITGAX CASP9 DLGAP5 CAP1 CR2 CASP3 PLSCR1 PLSCR3 MBL2-1 PLSCR4 MFGE8 GAS6 C1QB PRKCI CX3CR1 CRB2 COLEC12 COLEC11 CRB1 COLEC10 IFNG C1S C1R XIAP PARD6G ATP10A CYCS-1 PARD6B PARD6A BAK1 SUSD4 CD59 CSMD1 CD55 DEDD CR1L;CR1 DIABLO-1 BAX C3-1 MPP5 MERTK AXL FAS C1QC TGFB1 ITGB3 CELL DIFFERENTIATION INDEX%WIKIPATHWAYS_20260510%WP2029%HOMO SAPIENS Cell differentiation index HDAC5 TLX3 LEFTY2;LEFTY1 TLX2 TLX1 STAT3 SRF PRE IMPLANTATION EMBRYO%WIKIPATHWAYS_20260510%WP3527%HOMO SAPIENS Pre implantation embryo SOX2 ZFP36 DNMT3L KHSRP SIX3 SOX8 MYBL1 TEAD4 BATF3 FOXD1 SOX11 ZAR1 DPPA3 FOSB DDIT3 ZFP42 DLX2 SMARCA4 PADI6 POU5F1;POU5F1B ATP1A1 GATA2 EGR1 BARX2 ZFP36L2 LEUTX ELAVL1 NLRP5 NKX2-1 MTA3 ESRRA DPRX-1 TCF7L1 CDX2 IRX5 HNRNPAB PBX1 TBX3 KLF4 MOS NANOG;NANOGP8 TPRX1;RAX2 ZSCAN4 MXD1 TFAP2E;TFAP2B MACROH2A2 E2F5 CDH1 IRF4 GATA3 NANOGNB CELF3 AQP9 AQP3 NR3C2 FOXQ1 RENIN ANGIOTENSIN ALDOSTERONE SYSTEM RAAS %WIKIPATHWAYS_20260510%WP4756%HOMO SAPIENS Renin angiotensin aldosterone system RAAS HSD3B1;HSD3B2 STAR REN CAMK2B CYP11B1;CYP11B2 ITPR1 ATF2 CAMK2D CALML6 ITPR2 CALML3 CAMK2A ITPR3 CALML4 CREB1 CAMK2G CYP21A2 GNAQ ATF1 ATF6B CREB3L3 CREB3L4 CREB3L1 CALM3;CALM1 CREB3L2 CTSG CALM1 CAMK1D CAMK4 CALM2 CMA1 CREB3 CAMK1 AGTR1 AGTR2 CYP11A1 PLCB2 CAMK1G ATF4 CREB5 ACE AGT SELENIUM METABOLISM AND SELENOPROTEINS%WIKIPATHWAYS_20260510%WP28%HOMO SAPIENS Selenium metabolism and selenoproteins POU2F1 GPX4 GPX1 TXNRD3 TXNRD2 FABP1 GPX6 SECISBP2 TXNRD1 DIO1 DIO3 TRNAU1AP SP1 SELENOO SEPSECS SELENON SARS1 SARS2 SELENOS CTH SELENOP SP3 SCLY SELENOT JUN NFE2L2 FOS NFKB1 RELA RPL30 CREM SELENOK SELENOI SELENBP1 SEPHS1 SEPHS2 PSTK EEFSEC 2Q13 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP5222%HOMO SAPIENS 2q13 copy number variation syndrome IL2 ANAPC1 MAPK1 BCL2L11 STAT1 IL6 GRB2 IL1B RAC1 IL1RN CSF2 CSF1 ZC3H8 IL1RAP GAS6 ZC3H6 CXCL13 LGALS3 CHCHD5 ACOXL IL36A IL36B PSD4 ARL14 IL23A IL1R1 CKAP2L IL1A POLR1A POLR1B GATA3 POLR1C POLR1D POLR1E SOCS3 POLR1F POLR1G POLR1H ARF6 FBLN7 TMEM87B SLC20A1 TULP1 MERTK TTL IL1RL2 PLCG2 SOCS1 POLR2E POLR2F IL36RN POLR2H POLR2L IL37 IL36G IL1F10 PTK2 FAMILIAL HYPERLIPIDEMIA TYPE 3%WIKIPATHWAYS_20260510%WP5110%HOMO SAPIENS Familial hyperlipidemia type 3 LRP1 LPL LCAT APOA4 VLDLR LIPC LDLR APOE PLTP APOA2 APOA1 SCARB1 CETP OMEGA 9 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260510%WP4724%HOMO SAPIENS Omega 9 fatty acid synthesis ELOVL1 ELOVL5 ACSL1 ELOVL2 SCD5 ELOVL3 ACSL4 ELOVL6 ACSL3 FADS2 SCD FASN FADS1 ACOT2;ACOT1 TCA CYCLE AND DEFICIENCY OF PYRUVATE DEHYDROGENASE COMPLEX PDHC %WIKIPATHWAYS_20260510%WP2453%HOMO SAPIENS TCA cycle and deficiency of pyruvate dehydrogenase complex PDHc ACO1 DLAT PCK1 IDH3A FH PDHA1 MDH1 IDH1 DLST SDHA CS ACLY PC OGDH SUCLG2 DLD SEROTONIN AND ANXIETY RELATED EVENTS%WIKIPATHWAYS_20260510%WP3944%HOMO SAPIENS Serotonin and anxiety related events HTR2A CRH NLGN1 ARC PLEK HTR1A PRKCB PLCD4 GRIN2D CRHR1 PPP3CA FOS PYRIMIDINE METABOLISM AND RELATED DISEASES%WIKIPATHWAYS_20260510%WP4225%HOMO SAPIENS Pyrimidine metabolism and related diseases RRM2-1 TYMS AGXT2 GLS2 DPYS CAD ABAT RRM1 UPB1 TYMP DHODH NT5C3A NT5C ALDH6A1 RRM2B CPS1 DPYD TK2 UMPS OTC AEROBIC GLYCOLYSIS AUGMENTED%WIKIPATHWAYS_20260510%WP4628%HOMO SAPIENS Aerobic glycolysis augmented HK1 LDHA GAPDH-1 PKM PGK1 ALDOA PFKM GPI TPI1 PGAM2 SLC2A1 GPT ENO1 INSULIN SIGNALING IN ADIPOCYTES NORMAL CONDITION %WIKIPATHWAYS_20260510%WP3634%HOMO SAPIENS Insulin signaling in adipocytes normal condition IRS1 RPS6 RPS6KB1 TBC1D4 INSR SLC2A4 MTOR AKT2 NAD METABOLISM IN ONCOGENE INDUCED SENESCENCE AND MITOCHONDRIAL DYSFUNCTION ASSOCIATED SENESCENCE%WIKIPATHWAYS_20260510%WP5046%HOMO SAPIENS NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence IL6 TP53 SLC2A4 GOT1-1 G6PD IL1B GOT2-1 RELA MDH2 SIRT5 PRKAA1 NMNAT2 SIRT1 SIRT2 SIRT3 NAMPT CCL27 MDH1 ELAVL1 PARP1 SLC2A1 COPPER HOMEOSTASIS%WIKIPATHWAYS_20260510%WP3286%HOMO SAPIENS Copper homeostasis PTEN SP1 CCND1 GSK3B APP CASP3 STEAP3 AKT1 STEAP4 JUN COX17 MT2A PIK3CA ATP7B FOXO1-1 COX11 ATP7A PRNP SLC31A2 SLC31A1 SLC11A2 ADAM10 COMMD1 MT3 XIAP SOD3 ATOX1 BACE1 TP53 ADAM17 CCS SCO1 MTF1 FOXO3 MTF2 MDM2-2 ADAM9 STEAP1 STEAP2 SOD1 MAPT APC INSULIN SIGNALING IN ADIPOCYTES DIABETIC CONDITION %WIKIPATHWAYS_20260510%WP3635%HOMO SAPIENS Insulin signaling in adipocytes diabetic condition IRS1 RPS6 RPS6KB1 TBC1D4 INSR SLC2A4 MTOR AKT2 UTERINE NATURAL KILLER CELLS AND PROGESTERONE ESTROGEN AND CHORIONIC GONADOTROPIN%WIKIPATHWAYS_20260510%WP5569%HOMO SAPIENS Uterine natural killer cells and progesterone estrogen and chorionic gonadotropin CXCL10 IL3 IL6 CXCL11 CXCL12 SELL IL2RB PGR HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CD69 CCL3L1;CCL3L3;CCL3;CCL18 BCL2 CX3CL1 CXCL8 MAP2K4 GATA2 VEGFA MCL1 MAPK11 IFNG JAK1 IL2RG STAT5A CCL13;CCL2 NCR1-1 STAT5B CXCR4 JAK3 NR3C1 CCL8 IL4 CCL4L2;CCL4L1;CCL4 CCL5 TNF CXCR3 MRC1 MAPK3 MADCAM1 IL10 ANGPT2 VCAM1 ITGA4 ANGPT1 PIBF1 IL15 GAB3 ESR2 WNT SIGNALING NETPATH%WIKIPATHWAYS_20260510%WP363%HOMO SAPIENS Wnt signaling NetPath NFATC2 CTBP1 NLK CCND1 SOX1 CTNNB1 DVL1 GSK3B DVL2 TCF4 DVL3 TCF7L2 GCKR CDK6 RYK-1 AXIN1 RAC1 CSNK1D ROR1 AKT1 TPTEP2-CSNK1E;CSNK1E ROR2 TSC2 PI4K2A TSC1 CSNK1G1 MAPK1 PPARG RHOA PIP5K1B GSK3A LEF1 LRP5 MAPK9 MAP3K7 LRP6 MAPK8 PRKCG CSNK1A1 ARRB2 PRKCB PRKCA MTOR BCL9 APC VITAMIN B12 DISORDERS%WIKIPATHWAYS_20260510%WP4271%HOMO SAPIENS Vitamin B12 disorders TCN2 TCN1 MMUT MMACHC MMADHC CD320 CUBN AMN MTRR MMAA MMAB CBLIF MTR-1 VISUAL CYCLE%WIKIPATHWAYS_20260510%WP5534%HOMO SAPIENS Visual cycle RBP1 RDH8 ABCA4 RLBP1 RPE65 OPN1SW OPN1MW3;OPN1MW2;OPN1MW;OPN1LW RDH12 RBP3 RDH11 RDH10 RHO RDH5 LRAT PTDINS 4 5 P2 IN CYTOKINESIS PATHWAY%WIKIPATHWAYS_20260510%WP5199%HOMO SAPIENS PtdIns 4 5 P2 in cytokinesis pathway MYL2 RACGAP1 ANLN SEPTIN2 RAB35 AFAP1 KIF23 OCRL RDX EZR MSN RHOA BLADDER CANCER%WIKIPATHWAYS_20260510%WP2828%HOMO SAPIENS Bladder cancer MMP9 KRAS FGFR3 CCND1 CDKN2A ARAF MYC CXCL8 MMP1 CDH1 CDK4 HRAS VEGFA ERBB2 MAPK1 HBEGF RAF1 PIK3R2 PIK3R1 RPS6KA5 NRAS E2F1 TP53 EGF SRC MDM2-2 EGFR TYMP MAP2K2;MAP2K1 RB1 DAPK1-1 THBS1 RASSF1 MMP2 BRAF DAPK2 DAPK3 CDKN1A UPK3A MITOCHONDRIAL COMPLEX IV ASSEMBLY%WIKIPATHWAYS_20260510%WP4922%HOMO SAPIENS Mitochondrial complex IV assembly COX19 COX7B COX15 COX18 TACO1 COX4I1 COX7A2 HIGD1A COX5B COX6A1 COX7C COX5A PET117 COX14 COX10 COX8A COA3 SURF1 NDUFA4 CMC1 COX6C COX6B1 COX17 TMEM177 PNKD SMIM20 COX11 COX20 PGK1 PKM2 KHKC KHKA ACTING AS PROTEIN KINASES%WIKIPATHWAYS_20260510%WP5433%HOMO SAPIENS PGK1 PKM2 KHKC KHKA acting as protein kinases MYL2 PKM H3-3A PGK1 PAK2 BUB3 PDK1 STAT3 BECN1 PRPS1 SNAP23 KHK AKT1S1 HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20260510%WP186%HOMO SAPIENS Homologous recombination BRCA2 RAD54B POLD4 RAD50 RAD51 POLD1 POLD3 POLD2 NBN RPA1 RAD52 ATM MRE11 BIOMARKERS FOR PYRIMIDINE METABOLISM DISORDERS%WIKIPATHWAYS_20260510%WP4584%HOMO SAPIENS Biomarkers for pyrimidine metabolism disorders RRM2-1 TYMS PUS1 DPYS RRM1 UPB1 TYMP DHODH NT5C3A NT5C RRM2B DPYD TK2 UMPS CKB PRIMARY OVARIAN INSUFFICIENCY%WIKIPATHWAYS_20260510%WP5461%HOMO SAPIENS Primary ovarian insufficiency SOX8 STAR ZAR1 NOTCH2 ESR1 GNAS-1 COX10 BRCA2 RAD51 NBN NUP107 AMHR2 FMR1 PRORP PRDM1 RCBTB1 EIF4ENIF1 MEIOSIN POF1B MEIOB SIL1 SOHLH2;CCDC169-SOHLH2 HFM1 NANOS3 ATG9A LIG4 SGO2 LARS2 AR PREPL MSH4 CLPP MSH5 NOBOX KHDRBS1 BLM AARS2 AIRE SYCP2L ALOX12 MST1R HMMR WDR62 HSD17B4 ZP3;POMZP3 SALL4 STRA8 SYCE1 ANTXR1-1 SOHLH1 KASH5 SWI5 ATG7 EIF2B5 FANCI CYP19A1 EIF2B4 EIF2B2 HELQ XRCC4 FANCM FANCL CAV1 XRCC2 PMM2 FANCA FANCC ERAL1 RFWD3-2 HARS2 BMP6 DAZL GDF9 CPEB1 DIAPH2 STAG3 H1-8 BMPR1B HROB BMPR1A LHX8 BMPR2 BNC1 MCM8 MCMDC2 MCM9 LAMC1 ELAVL2 BMP15-1 EXO1 EIF2B1 AMH POLG C1orf146 FIGLA MRPS22 TWNK FOXL2 SPIDR C14orf39 NR5A1 TGFBR3 PPM1B HAX1 PCCA FSHR DMC1 PCCB GALT CYP17A1 PSMC3IP WRN PGRMC1 DCAF17 SLX4 HSD17B1 POLR2C LMNA NUP43 SHOC1 CCDC185 MGME1 MND1 MLH1 CENPE WT1 XPNPEP2 SPATA33 POLR3H ERCC6 LGR4 TP63 ATM ESR2 OSTEOARTHRITIC CHONDROCYTE HYPERTROPHY%WIKIPATHWAYS_20260510%WP5373%HOMO SAPIENS Osteoarthritic chondrocyte hypertrophy FOSL2 FOSL1 FOSB AKT2 AKT3 KDR JAK2 JUN VEGFA PIK3CA MAPK1 NFKB1 NTRK1 PRKCA STAT3 FGFR4 FGFR3 FGFR2 FGFR1 AKT1 JUNB FOS IBSP COL10A1 SOX9 CCN2 NGF GANC MMP13 COL2A1 ARNT DDR2 CEBPB HIF1A FGF23 EPAS1 RELB RELA ACAN SPP1 VHL CNMD P4HTM COL1A1 COL3A1 LAMTOR1 RUNX2 MAPK3 JUND HALLMARK OF CANCER METASTASIS AND EPITHELIAL TO MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260510%WP5469%HOMO SAPIENS Hallmark of cancer metastasis and epithelial to mesenchymal transition HDAC2 HDAC1 SUZ12 TCF4 SIRT1 SUV39H1 CDH1 FOXC2 EZH2 PRRX1 SIX1 GRHL2 KLF8 TGFB1 ZEB2 ZEB1 SNAI1 ELF3 KDM1A ELF5 SNAI2 GSC2 GANGLIO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260510%WP5299%HOMO SAPIENS Ganglio series sphingolipid metabolism HEXA B3GALT4 NEU3 NEU4 ST3GAL4 ST8SIA5 ST3GAL5 B4GALNT1 ST8SIA6 ST3GAL1 ST3GAL2 ST8SIA1 HEXB AIRWAY SMOOTH MUSCLE CELL CONTRACTION%WIKIPATHWAYS_20260510%WP4962%HOMO SAPIENS Airway smooth muscle cell contraction GNAQ PPP1R14A GDI1 MYLK IL13 CALM1 ITPR3 PPP1CB CD38 RYR1 ADRB2 PLCB1 ROCK1 ROCK2 MYL1 RHOA PILOCYTIC ASTROCYTOMA%WIKIPATHWAYS_20260510%WP2253%HOMO SAPIENS Pilocytic astrocytoma KRAS NRAS GRB2 SOS1 HRAS PTPN11 BRAF RAF1 NF1 IL6 SIGNALING%WIKIPATHWAYS_20260510%WP364%HOMO SAPIENS IL6 signaling HDAC1 IL6 GRB2 SHC1-1 NLK VAV1 GSK3B MAP2K4 CRP JAK2 TIMP1 IL6R GAB1 RAC1 CREBBP NR2F6 AKT1 HCK IRF1 JUNB VIP IL6ST MAPK1 TYK2 PIK3R2 PIK3R1 NCOA1 SOS1 BCL2L1 SOCS3 BAD JAK1 PTPN11 PRDM1 MAP3K7 STAT1 MAP2K2;MAP2K1 RPS6KB1 MAPK3 PRKCD STAT3 AGT BEMPEDOIC ACID THERAPY IN ATHEROSCLEROSIS AND METABOLIC SYNDROME%WIKIPATHWAYS_20260510%WP5500%HOMO SAPIENS Bempedoic acid therapy in atherosclerosis and metabolic syndrome PRKAA1 CRP ACACB MAPK1 PCK2 G6PC1 ACLY G6PC2 G6PC3 MAPK12 SLC27A2 MAPK11 PRKAB2 PRKAB1 PRKAA2 MAPK10 ACACA MAPK9 MAPK8 PRKAG1 PRKAG2 MAPK13 PRKAG3 MAPK3 MAPK14 ERYTHROPOIESIS%WIKIPATHWAYS_20260510%WP5607%HOMO SAPIENS Erythropoiesis TFRC EPO IL3 EPOR CD79A KITLG TF PTPRC IL3RA CD34 HBG2;HBG1 HBZ GATA2 HBD;HBB GATA1 FAS HBA2;HBA1 FASLG GDF11 KIT DISORDERS OF BILE ACID SYNTHESIS AND BILIARY TRANSPORT%WIKIPATHWAYS_20260510%WP5176%HOMO SAPIENS Disorders of bile acid synthesis and biliary transport CYP8B1 CYP7A1 SCP2 ATP8B1 HSD17B4 SLC27A2 ABCB1 ABCD3 ABCB4 AKR1D1 ABCB11 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC3 ABCC4 HSD3B7 ABCC2 SLC10A1 SLC10A2 SLC51A BAAT SLC51B CYP7B1 CYP27A1 AMACR ACOX2 FABP6 SLC27A5 MITOCHONDRIAL IMMUNE RESPONSE TO SARS COV 2%WIKIPATHWAYS_20260510%WP5038%HOMO SAPIENS Mitochondrial immune response to SARS CoV 2 CGAS ACE2 PHB2 MAVS IFIH1 TBK1 STING1 IKBKE TRAF3 CTSV;CTSL DDX58 TICAM1 REN IRF3 NDUFAF1 IRF7 NOX1 TLR7 TLR3 NFKB2 TRAF6 NFKB1 AGTR1 NLRX1 AGTR2 PHB ECSIT TOMM70 ACE ACAD9 BCS1L NDUFB9 TMPRSS2 SERINE METABOLISM%WIKIPATHWAYS_20260510%WP4688%HOMO SAPIENS Serine metabolism PSPH TYMS SHMT1 SRR SHMT2 DHFR2;DHFR PSAT1 PHGDH ARACHIDONIC ACID AA ARA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260510%WP5155%HOMO SAPIENS Arachidonic acid AA ARA oxylipin metabolism TBXAS1 PTGS2-2 PTGS1 EPHX2 ARSENIC METABOLISM AND REACTIVE OXYGEN SPECIES GENERATION%WIKIPATHWAYS_20260510%WP5233%HOMO SAPIENS Arsenic metabolism and reactive oxygen species generation COA3 AS3MT ATP1A1 GSTO1 CAT UQCRFS1 SOD1 VDAC1 SDHA G PROTEIN SIGNALING%WIKIPATHWAYS_20260510%WP35%HOMO SAPIENS G protein signaling PLCB3 ARHGEF1 ADCY4 GNAI3 ADCY3 HRAS ADCY2 ADCY1 ADCY8 ADCY7 GNAI1 RRAS ADCY6 GNA13 GNAI2 ADCY5 GNA12 PRKACB-1 GNG5 GNG4 GNA11 GNG8 KCNJ3 PRKCG PRKCH PRKCB PRKCE PRKCD PRKCA GNAS-1 ADCY9 PRKAR1B KRAS PRKAR1A PRKCQ PRKD1 GNAZ ITPR1 PRKCZ PRKAR2B AKAP9-1 AKAP12 PRKAR2A AKAP13 AKAP10 PPP3CA AKAP11 PRKCI PPP3CC GNG13 PDE4B GNAO1 PDE4A PDE8B RHOA PDE8A PDE4C PRKD3 SLC9A1 NRAS PDE1C GNAQ PDE1B PDE1A AKAP8 GNB2 AKAP7 AKAP6 GNB1 AKAP5 AKAP4 GNB3 AKAP3 GNB5 AKAP1 GNA14 CALM1 GNA15 GNG10 PDE4D-1 GNAL PDE7B PDE7A GNGT1 PRKACA-1 PYRIMIDINE METABOLISM%WIKIPATHWAYS_20260510%WP4022%HOMO SAPIENS Pyrimidine metabolism DCTD NME6 NME7 CMPK1 CMPK2 UPRT DCTPP1 PRIM2 DTYMK NME4-1 POLR2A POLR2B POLR2D NT5M POLR2G POLR2I DUT PNPT1 POLR3GL UCKL1 POLE4 POLA2 UCK1 POLR2J;POLR2J2;POLR2J3 POLR3A POLR3B POLR3C POLR3D POLE3 POLR3E POLR3F POLR3G POLR3K DPYS CAD UPB1 TYMP DHODH NT5C RRM2B DPYD TK2 UMPS POLR2C POLE POLR3H DCK RRM2-1 POLD4 PRIM1 TYMS POLD1 POLR1A POLD3 POLD2 POLR1B POLR1C POLR1D POLR1E POLR1F POLR1H RRM1 CDA ENPP1 POLA1 ENPP3 POLR2E UPP1 TK1 POLE2 ENTPD1 POLR2H ENTPD3 POLR2L NME2 NME3 CTPS2 CTPS1 NME1 SNARE COMPLEX MACHINERY IN EXOCYTOSIS%WIKIPATHWAYS_20260510%WP5621%HOMO SAPIENS SNARE complex machinery in exocytosis NAPA NSF SNAP25 UNC13A SYT1 STXBP1 SYP CACNA1B CPLX1 RPH3A CACNA1A RIMS1 STXBP5 GDI1 STXBP6 VAMP2 RAB3A ACETAMINOPHEN IN ANALGESIA AND ANTIPYRESIS%WIKIPATHWAYS_20260510%WP5444%HOMO SAPIENS Acetaminophen in analgesia and antipyresis KCNQ2 KCNQ3 TRPV1 HTR1A PTGS2-2 PTGS1 CACNA1H FAAH TRPA1 EICOSANOID METABOLISM VIA LIPOOXYGENASES LOX %WIKIPATHWAYS_20260510%WP4721%HOMO SAPIENS Eicosanoid metabolism via lipooxygenases LOX DPEP1 ACOX3 ALOX15 ALOX12 ACOX1 PPARA PPARD TRPA1 TRPV1 HPGD FPR2 LTC4S LTB4R CYSLTR1 CYSLTR2 EHHADH-1 LTA4H ALOX5 PTGR1-1 GGT5 ACAA1-1 ACOX2 CYP4F3;CYP4F2;CYP4F12;CYP4F11 PTGR2 ALOX15B LTB4R2 ETHANOL METABOLISM PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20260510%WP4269%HOMO SAPIENS Ethanol metabolism production of ROS by CYP2E1 MAPK8 CYP2E1 MAP2K2;MAP2K1 MAFG MAFF MAFK SP1 NFE2L2 EXTRACELLULAR VESICLES IN THE CROSSTALK OF CARDIAC CELLS%WIKIPATHWAYS_20260510%WP4300%HOMO SAPIENS Extracellular vesicles in the crosstalk of cardiac cells MMP9 IL6 PTEN CD63 TLR4 CD81 EGF HSPB1 GATA4 SORBS2 IGF1 ETS2 SPP1 PDLIM5 EGFR KDR SOD1 BIRC5 STAT3 GLP 1 SECRETION FROM INTESTINE TO PORTAL VEIN%WIKIPATHWAYS_20260510%WP5446%HOMO SAPIENS GLP 1 secretion from intestine to portal vein GCG GNAQ PCSK1 SLC5A1-1 SLC2A2 COVID 19 ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260510%WP4891%HOMO SAPIENS COVID 19 adverse outcome pathway IL2 ACE2 CXCL10 IL6 CCL3L1;CCL3L3;CCL3;CCL18 IL1B CCL13;CCL2 CXCL8 CSF3 IL7 TNF IL2RA IL10 TMPRSS2 AGT POLYCYSTIC KIDNEY DISEASE PATHWAY%WIKIPATHWAYS_20260510%WP2571%HOMO SAPIENS Polycystic kidney disease pathway FLT1 STK11 IGF1R CCND1 CTNNB1 MYC DVL1 DVL2 PRKAA1 DVL3 KDR GNAI3 HRAS IKBKB JUN TSC2 GNAI1 TSC1 ADCY6 GNAI2 ERBB2 GNA11 PRKAB2 PRKAB1 SRC WNT1 PRKAG1 PRKAG2 PRKAG3 TNF RPS6KA1 FZD6 MTOR GNAS-1 RHEB SLC12A2 KRAS IGF1 GSK3B WNT2B FZD10 PKD2 PKD1 WNT5B WNT9B WNT9A WNT16 SSTR2 SFRP4 CFTR FOS WNT8A WNT8B WNT6 WNT11 NRAS KCNN4 WNT2 GNAQ WNT3 PDE1A WNT10B WNT10A FZD3 EGF PRKAA2 FZD2 FZD5 FZD4 WNT3A WNT7B FZD7 FZD9 VEGFB WNT7A FZD8 MAP2K2;MAP2K1 FZD1 WNT5A PLCG2 MAPK3 BRAF WNT4 SLEEP REGULATION%WIKIPATHWAYS_20260510%WP3591%HOMO SAPIENS Sleep regulation UTS2R BTBD9 OXT-1 IL6 HCRTR2 HCRTR1 ADORA2A MTNR1B STAR GHRH GHRL SLC29A1 ADA MRGPRX3;MRGPRX4;MRGPRX1;MRGPRX2-3 HTR2A FOS GRIN2A DLAT CRH NLGN1 TH OXTR AHCY NPY2R NPAS2 NPS CST3 CACNA1I ADORA1 DRD1 PTGDS IL18 DRD2 DRD3 PTGDR CHRNB2 FUMARATE HYDRATASE DEFICIENT PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260510%WP4241%HOMO SAPIENS Fumarate hydratase deficient papillary renal cell carcinoma EP300 RBX1 SETD2 PRCC DVL2 CUL2 ELOC-1 CTSK ELOB SFPQ-1 EGLN1 CREBBP EGLN3 FH EGLN2 CADM2 VEGFA TFE3 TFEB COL21A1 BIRC7 TGFA PDGFB TGFB2 TGFB3 ARNT HIF1A EPAS1 VHL DIAPH1 TGFB1 SLC2A1 CDKN1A SMITH MAGENIS AND POTOCKI LUPSKI SYNDROME COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5381%HOMO SAPIENS Smith Magenis and Potocki Lupski syndrome copy number variation PPP1R14A BIRC2 PRKAA1 JUN TFE3 TFEB FOXA1 G6PC1 TRAF3IP1 FHOD1 FERD3L MAP3K14 IFT172 GRIP1 NFKB1 ALKBH5 MAEA MPRIP DENR USP8 PRKAB1 HES6 MIGA2 MIGA1 MED9 IFT80 ARMC8 ATG13 DRC3-1 IFT88 YAP1-1 RNF41 IFT81 TOM1L2 TTC30A;TTC30B CDK1 RRAGA ULK1 LLGL1 IQCA1 DRC7 ATPAF2-2 FLII PRKAG2 GPR85 CLEC16A SHMT1 COPS7A PLD6 RAI1 ATG101 WWTR1 RAB39B COPS4 COPS3 COPS6 IFT22 COPS5 COPS2 TOLLIP PEMT HBP1 IFT20 DRC1 COPS8 MYD88 TNFRSF13B CLTC NR1H2 IFT27 GDI2 CLTB TTC26 WDR41 CLTA FLCN RB1CC1 EFCAB2 HSPB11 RAB8A IFT52 SREBF1 ARG2 CFL2 RMI2 RMI1 TOP3A ITPK1 IQCD IFT57 TCTE1 IQCG ETV5 CRY2 IRF8 SMCR8 GAS8 C9orf72 PRKN WDR26 GPS1 MIEF2 RASD1 RMND5A IFT46 APBB1 FNIP1 FNIP2 RANBP9 FBXL13 MYO16 PRDM1 IFT74 RAB10 MKLN1 GID4 MYO15A CARM1 DRG2 CCDC65 FOXA2 CLUAP1 BLM PTEN PPP1R12A RPTOR MYC NT5M MLST8 ROCK1 LIMK1 PCK1 BCL2L11 TP53 PARD3 TNF STAT3 MTOR NR1H3 LDHA BCL6 IL1B APP PRKCI RHOA CREB1 CRY1 TLR4 CLOCK PARD6B ARNTL RELA BAX PER1 PRION DISEASE PATHWAY%WIKIPATHWAYS_20260510%WP3995%HOMO SAPIENS Prion disease pathway EP300 RXRA FYN BATF FGFR1 BCL2 MEF2C ELK1 CASP3 MAPK1 PRNP BCL11A RAD21 NFKB1 CREB1 IRF4 NCAM1 SPI1 CTCF MAPK3 CHD2 SMC3 HSP90B1 PDIA3 TBP STAT3 HSPA5 EBF1 PAX5 POU2F2 PTK2 RFX5 VEDOLIZUMAB THERAPY FOR INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260510%WP5512%HOMO SAPIENS Vedolizumab therapy for inflammatory bowel disease SELPLG ITGA2 ITGB7 SELE ICAM1 MADCAM1 ITGB1 VCAM1 ITGB2 ITGA4 WHITE FAT CELL DIFFERENTIATION%WIKIPATHWAYS_20260510%WP4149%HOMO SAPIENS White fat cell differentiation CEBPA CEBPD MECOM CTNNA1 IRF3 ZNF423 TLE3 EGR2 NR2F2 KLF15 DDIT3 KLF2 KLF5 SREBF1 GATA2 RORA INS;INS-IGF2 FOXO1-1 TCF7L1 PPARG RARA CREB1 KLF4 IRF4 WNT10B GATA3 CEBPB STAT5A STAT5B NR3C1 EBF1 NR1H3 INFLUENZA A VIRUS INFECTION%WIKIPATHWAYS_20260510%WP1438%HOMO SAPIENS Influenza A virus infection BCL2 PHOTODYNAMIC THERAPY INDUCED HIF 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260510%WP3614%HOMO SAPIENS Photodynamic therapy induced HIF 1 survival signaling HK1 LDHA PKM PGK1 BNIP3 PTGS2-2 SERPINE1 BCL2A1 PMAIP1 HIF1AN EGLN1 BNIP3L EDN1 SLC16A1 PDHA1 IGFBP3 VEGFA BIRC5 IGFBP2 PFKL MCL1 NOS2 TGFA EPO IGFBP1 TGFB3 BID TP53 BCL2L1 ARNT HIF1A BAK1 BAX ANGPT2 ANGPT1 SLC2A1 GLUTATHIONE METABOLISM%WIKIPATHWAYS_20260510%WP100%HOMO SAPIENS Glutathione metabolism GPX4 ANPEP GPX1 GCLM GGT1 G6PD GSTA3;GSTA5;GSTA1;GSTA2 IDH1 GSS GSR GGT5 GSTT2B;GSTT2 OPLAH GSTM1;GSTM2-1 GSTA3;GSTA1 GCLC ULCERATIVE COLITIS SIGNALING%WIKIPATHWAYS_20260510%WP5174%HOMO SAPIENS Ulcerative colitis signaling IFNG NOD2 IL5 MAF TLR2 GATA3 HLA-DMA IL13 IL2RG STAT6 NFATC1 IL4 TNF IL10 TGFB1 IL4R NFKB1 FOXP3 MAP3K1 ROLE IN PROMOTING AND BLOCKING GONADAL DETERMINATION%WIKIPATHWAYS_20260510%WP4872%HOMO SAPIENS MAP3K1 role in promoting and blocking gonadal determination MAPK11 SOX9 SRY FGFR2 MAP3K4 CTNNB1 GSK3B GADD45G AXIN1 FGF9 ROCK1 MAP3K1 MAPK1 FOXL2 RHOA WNT4 NEURAL CREST CELL MIGRATION DURING DEVELOPMENT%WIKIPATHWAYS_20260510%WP4564%HOMO SAPIENS Neural crest cell migration during development MMP9 PIK3CD PIK3CB PIK3CG BUB1B-PAK6;PAK6 AKT2 AKT3 PIK3R4 RAC1 PIK3R6 AKT1 JUN PIK3R5 PIK3CA PIK3R3 FOS RHOA PAK1 PAK3 PAK2 PAK5 PAK4 TRIO EPHB6 ARF1 EPHB2 BDNF EPHB1 EPHB4 EPHB3 MMP8 TIAM1 CDH11 F2RL2 NGEF NGFR STAT3 MMP2 METABOLIC REPROGRAMMING IN COLON CANCER%WIKIPATHWAYS_20260510%WP4290%HOMO SAPIENS Metabolic reprogramming in colon cancer SDHB LDHA GLUD1;GLUD2 GAPDH-1 RPIA PKM ALDOB PGK1 ACO2 TKT G6PD GOT2-1 MDH2 SHMT2 PSAT1 PSPH FASN FH PDHA1 PFKL DLST ACLY SUCLG2 IDH3A SLC1A5 PDHB GLS HK3 SLC16A3 TIGAR GPI PGAM1 IDH2 TALDO1 SLC2A1 PYCR1 PYCR2 PGD ENO1 PAICS CELL TYPE DEPENDENT SELECTIVITY OF CCK2R SIGNALING%WIKIPATHWAYS_20260510%WP3679%HOMO SAPIENS Cell type dependent selectivity of CCK2R signaling GNAQ DAGLA TRPC1 CCK ITPR1 CNR1 CD38 RYR1 PLCB1 RYR2 GNAI1 RYR3 CCKBR NEURODEGENERATION WITH BRAIN IRON ACCUMULATION NBIA SUBTYPES PATHWAY%WIKIPATHWAYS_20260510%WP4577%HOMO SAPIENS Neurodegeneration with brain iron accumulation NBIA subtypes pathway STK11 SCP2 RPTOR DEPTOR PLA2G6 WDR45 MECP2 DCAF17 SPTLC1 PRKAA1 MAP1LC3A RB1CC1 MLST8 ATG5 ATG3 PIK3C3 PIK3R4 ATG7 FTL-1 ATG10 WIPI1 WIPI2 C19orf12 GTPBP2 TSC2 ATG14 TSC1 CP COASY FA2H BECN1 ATG12-1 ATG16L1 ATG2A AKT1S1 ATP13A2 ATG4A ATG13 ACACA ULK1 ATG101 MTOR RHEB ONE CARBON METABOLISM%WIKIPATHWAYS_20260510%WP241%HOMO SAPIENS One carbon metabolism SHMT2 MTRR DHFR2;DHFR MTR-1 ST20-MTHFS;MTHFS TCN2 ALDH1L1 MTFMT DNMT1 AHCYL2 GLRX MAT2B TYMS FTCD ATIC MTHFD1L DNMT3B DNMT3A MTHFR MAT1A BHMT FOLH1B;FOLH1 MTHFD1 MTHFD2 CHDH GART AHCY SHMT1 AMT IL1 AND MEGAKARYOCYTES IN OBESITY%WIKIPATHWAYS_20260510%WP2865%HOMO SAPIENS IL1 and megakaryocytes in obesity MMP9 IFNG IL1R1 ICAM1 TLR2 MYD88 F2 IL1B CCL13;CCL2 TIMP1 PLA2G7 TLR1 IRAK1 TIMP2 NLRP3 FCER1A PIK3CA S100A9 CCR3 F2R HBEGF IL18 SELENBP1 NFKB1 FGFR3 SIGNALING IN CHONDROCYTE PROLIFERATION AND TERMINAL DIFFERENTIATION%WIKIPATHWAYS_20260510%WP4767%HOMO SAPIENS FGFR3 signaling in chondrocyte proliferation and terminal differentiation FGFR3 ATG5 FGF9 MAPK1 RAF1 MAPK12 MAPK11 SOX9 STAT1 PPP2CB;PPP2CA MAP2K2;MAP2K1 MAPK13 MAPK3 RBL1 BMP4 SNAI1 CNP THRA NPR2 FGF18 IHH MAPK14 BMP2 PTH1R CDKN1A PTHLH FGF23 SIGNALING IN HYPOPHOSPHATEMIC RICKETS AND RELATED DISORDERS%WIKIPATHWAYS_20260510%WP4790%HOMO SAPIENS FGF23 signaling in hypophosphatemic rickets and related disorders KL GALNT3 PTH SLC34A1 DMP1 ORAI1 PHEX CYP27B1 FGFR3 CYP24A1 FGFR2 CYP11B1;CYP11B2 FAM20C FGF23 ALPL CCND1 ROS1 SPP1 ENPP1 NFKB2 NFKB1 CDKN1A PI3K AKT MTOR SIGNALING AND THERAPEUTIC OPPORTUNITIES IN PROSTATE CANCER%WIKIPATHWAYS_20260510%WP3844%HOMO SAPIENS PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer KRAS PTEN PIK3CB PIK3CG RPTOR FOXO4 GRB10 GSK3B RB1CC1 MLST8 MAPKAP1 RICTOR HRAS AKT1 TSC2 TFEB PIK3CA FOXO1-1 PIK3R3 PIK3R2 PIK3R1 EIF4EBP1 NRAS ATG13 FOXO3 BAD PDK1 ULK1 CDKN1B NOS3 MTOR RHEB SARS COV 2 INNATE IMMUNITY EVASION AND CELL SPECIFIC IMMUNE RESPONSE%WIKIPATHWAYS_20260510%WP5039%HOMO SAPIENS SARS CoV 2 innate immunity evasion and cell specific immune response CXCL10 EP300 CXCL11 CXCL12 CCL3L1;CCL3L3;CCL3;CCL18 CXCL9 TRADD CXCL17 IFIT2 AP1G1 DHX58 IL6R BSG TRIM25 CXCL5;CXCL6 HAVCR2 IFNAR2 LAG3 PF4;PF4V1-1 TRAF6 CXCL2;CXCL3;CXCL1-1 TRAF2 LARP1-1 TRAF5 IFITM3;IFITM2;IFITM1 NFKB1 NUP98 SMAD2;SMAD3 IFNAR1 TANK CASP8 CXCR2 RIPK1 FADD RAE1 IFNB1-4 CD160 STAT2 PPBP MX1-1 TP53I3 JAK1 STAT1 TNF ACE2 HDAC2 MAVS IL6 TBK1 TRAF3 DDX58 IRF3 IRF7 TLR7 CXCL8 CSF2 CXCL13 CCL13;CCL2 CCL4L2;CCL4L1;CCL4 CCL5 TFAP2A IL10 TGFB1 MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260510%WP4190%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway IDI1 FDPS MVK GGPS1 IDI2 ACAT2 ACAT1 HMGCL PMVK MVD FDFT1 HMGCR HMGCS1-1 KIT RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP304%HOMO SAPIENS Kit receptor signaling EP300 FYN VAV1 GRB10 PTPN6 JAK2 HRAS MAPK1 RAF1 KIT SOS1 KITLG SRC FOXO3 STAT5A LYN STAT5B STAT1 RPS6 RPS6KB1 BTK RPS6KA3 RPS6KA1 MAPT PRKCB MATK GAB2 DOK1 PRKCA GRB7 STAT3 INPP5D SOCS6 SH2B2 TEC GRB2 SHC1-1 CRKL AKT1 MITF CRK CBL PIK3R2 PIK3R1 BAD PTPN11 MAPK8 MAP2K2;MAP2K1 SOCS1 PLCG1 MAPK3 MAPK14 TRANSCRIPTIONAL ACTIVATION BY NRF2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20260510%WP3%HOMO SAPIENS Transcriptional activation by NRF2 in response to phytochemicals AIMP2 HMOX1 GCLM NQO1 KEAP1 MAF CEBPB GSTA3;GSTA5;GSTA1;GSTA2 EPHB2 MAPK8 PIK3CA PRKCA NFE2L2 SLC7A11 GCLC MICROGLIA PATHOGEN PHAGOCYTOSIS PATHWAY%WIKIPATHWAYS_20260510%WP3937%HOMO SAPIENS Microglia pathogen phagocytosis pathway NCF1 NCF2 ARPC1B PIK3CD RAC3 NCF4 PIK3CB TREM2 PIK3CG TREM1 NCKAP1L ITGAM FCGR1A ITGB2 VAV3 FCER1G VAV1 SIGLEC9;SIGLEC7;SIGLEC8;SIGLEC12-1 CYBB PTPN6 CYBA TYROBP PIK3C3 PIK3C2A RAC1 VAV2 PIK3R6 HCK PIK3CA C1QB PIK3R3 PIK3R2 PIK3R1 LYN SYK PLCG2 C1QC LAT CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260510%WP5304%HOMO SAPIENS Cholesterol metabolism LRP1 LPL LCAT APOA4 LIPC LDLR STAR HMGCS1-1 APOE ABCA1 IDI1 FDPS MVK ABCB11 DHCR7 ACAT2 PMVK MVD FDFT1 CYP27A1 APOA2 HMGCR APOA1 APOC3 CYP7A1 PLTP CYP51A1 PCSK9 MSMO1 LIPA TM7SF2 NSDHL NPC1-1 LIPG VDAC1 TSPO CD36 LDLRAP1 LBR STARD3 MYLIP ABCG8 ABCG5 DGAT1 LSS SOAT1 NPC2 ANGPTL8 ANGPTL3 SLC27A4 LRPAP1 SAR1B MTTP HSD17B7 EBP NPC1L1 APOH SC5D MGAT1 APOB OSBPL5 SORT1 CIDEB DHCR24 FABP2 SQLE VAPA APOC2 APOC1 SCARB1 CETP MACROPHAGE MARKERS%WIKIPATHWAYS_20260510%WP4146%HOMO SAPIENS Macrophage markers CD14 CD86 CD74 CD163 CD83 LYZ-1 CD68 F3 ANDROGEN RECEPTOR NETWORK IN PROSTATE CANCER%WIKIPATHWAYS_20260510%WP2263%HOMO SAPIENS Androgen receptor network in prostate cancer CHEK1 SMARCC1 CDC25B HSD3B1;HSD3B2 SMARCC2 ACTL6B SP1 BCL2 RASA1 CDKN2A ACTL6A ARID1A ARID1B SMARCA4 BRCA1 PRKDC MMP1 CDK4 RICTOR JUN PIK3CA MAPK1 FOXA1 RAF1 SMAD2;SMAD3 PLK1 ATF1 CDK2 CDK1 ATR ABCC4 CDKN2B MRE11 PXN MSH6 RAD50 HSD17B7 BARD1 AR CDKN1A SPINK1 HGF MSH2 BLM EIF4E1B PTEN ERG FKBP5 NDRG1 NOXA1 F13B RPTOR KLK3;KLK2 HSD17B4 CCND1 MAP4K1 ETV4 MYC RAPGEF1 HSD17B3 CPN1 HSD17B2 PTK2B SPRY2 DOCK1 SPRY1 HRAS TSC2 TSC1 CASP8 SOS1 TP53 MDM2-2 RAP1A JAK1 STAT1 STAT3 MTOR RHEB GRB2 CYP17A1 CRKL HSD17B1 ELK1 CASP9 GAB1 CASP3 AKT1 CRK FOS EIF4EBP1 PAK1 E2F1 BAD PTPN11 RAP1B BAX CDKN1B CDC25A MAPK8 MAP2K2;MAP2K1 RB1 ATM MAPK3 SMARCD1 SMARCD2 SMARCD3 MAPK14 CHEK2 DIFFERENTIATION OF WHITE AND BROWN ADIPOCYTE%WIKIPATHWAYS_20260510%WP2895%HOMO SAPIENS Differentiation of white and brown adipocyte CEBPA ZNF423 CEBPG HSPB7 SLC7A10 PLAC8 ZIC1 PRDM16 HOXC9 HOXC8 PPARGC1B MPZL2 EBF3;EBF1 PPARG ADIPOQ CIDEA BMP7 LEP PPARGC1A CEBPB SMAD1 BMP4 SMAD9 SMAD5 BMP2 GLUCOSE METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260510%WP5211%HOMO SAPIENS Glucose metabolism in triple negative breast cancer cells HK1 LDHA PDP1 PKM PFKP SLC16A1 PDK1 SLC2A1 SMC1 SMC3 ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260510%WP5118%HOMO SAPIENS SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome MDC1 SMC1A RAD50 PAXIP1 RAD18 ATM NBN SMC3 RAD21 MRE11 BRCA1 SEROTONIN AND ANXIETY%WIKIPATHWAYS_20260510%WP3947%HOMO SAPIENS Serotonin and anxiety POMC GABRA1 CRH ARC PLEK EEF2K PLCD4 CAMK2B GRM1 FMR1 HTR2A TRPV1 HTR1A PRKCB ADRA1A PPP3CA FOS CONVERSION OF ANGIOTENSINOGEN TO ANGIOTENSIN II %WIKIPATHWAYS_20260510%WP4818%HOMO SAPIENS Conversion of angiotensinogen to angiotensin II REN CTSD ACE CTSG CMA1 SMALL LIGAND GPCRS%WIKIPATHWAYS_20260510%WP247%HOMO SAPIENS Small ligand GPCRs MTNR1B PTGER4 PTGFR CNR1 PTGIR PTGER1 PTGER2 PTGER3 PTAFR LPAR1 GPR50 MTNR1A CNR2 TBXA2R S1PR1 S1PR3 S1PR2 S1PR4 PTGDR DOCOSAHEXAENOIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260510%WP5154%HOMO SAPIENS Docosahexaenoic acid oxylipin metabolism PTGS2-2 EPHX2 MIR 124 PREDICTED INTERACTIONS WITH CELL CYCLE AND DIFFERENTIATION %WIKIPATHWAYS_20260510%WP3595%HOMO SAPIENS mir 124 predicted interactions with cell cycle and differentiation STK11 PTBP1 SIX4 CTDSP1 STRADB PRKAA1 15Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP4940%HOMO SAPIENS 15q11 2 copy number variation syndrome TUBGCP6 TUBGCP3 TUBGCP4 NIPA2 FMR1 CYFIP1 TUBGCP2 TUBGCP5 NIPA1 THIAMINE METABOLIC PATHWAYS%WIKIPATHWAYS_20260510%WP4297%HOMO SAPIENS Thiamine metabolic pathways BCKDK BCKDHA TKT PDHA1 SLC25A19 TPK1 SLC19A3 SLC19A2 OGDH MOLECULAR PATHWAY FOR OXIDATIVE STRESS%WIKIPATHWAYS_20260510%WP5477%HOMO SAPIENS Molecular pathway for oxidative stress CHEK1 PTEN KEAP1 ICAM1 PTGS2-2 ATF2 BCL2 CUL3 IKBKB TSC1 PIK3CA FOXO1-1 NFE2L2 IKBKG NOS2 NFKB1 RPS6KA5 TP53 BCL2L1 MAP2K3 CDK2 MDM2-2 ATR TNF MTOR RHEB HMOX1 IL6 NOX1 IPCEF1 NRF1 PIP-1 GSX1 CXCL8 SOD2 SIRT1 PINK1 MAP2K4 CAT AKT1 MAP3K5 FOS CREB1 NQO1 IL1A MAPK8 CCNE1 MAPK14 CDKN1A NOTCH1 REGULATION OF ENDOTHELIAL CELL CALCIFICATION%WIKIPATHWAYS_20260510%WP3413%HOMO SAPIENS NOTCH1 regulation of endothelial cell calcification FGFR3 ITGA1 ALPL GJA5 NOTCH1 LPAR1 JAG2 PLAT DLL1 SAT1 DLL3 JAG1 DLL4 VEGFA MGP CALU SOX6 PHOSPHATIDYL INOSITOL PHOSPHATE PATHWAY%WIKIPATHWAYS_20260510%WP5411%HOMO SAPIENS Phosphatidyl inositol phosphate pathway PTEN PLCB3 PIK3CD PIK3CB PIK3CG PLCB1 PIK3C2G PIK3C2A PIK3C2B PIP4K2A PIP4K2B PI4K2A PIP4K2C PIK3CA MTMR1 PI4K2B MTMR2 MTMR8 MTMR6 MTM1 PIP4P2 PIP4P1 INPP5K PLCE1 SACM1L PIP5K1A IPMK PIP5K1B TPTE;TPTE2 PIP5K1C FIG4 INPP4A PLCD4 INPP4B PIKFYVE PLCB4 PI4KA PI4KB PLCD3 PLCD1 PLCB2 PLCG2 PLCG1 OCRL INPP5E INPP5D MAMMALIAN DISORDER OF SEXUAL DEVELOPMENT%WIKIPATHWAYS_20260510%WP4842%HOMO SAPIENS Mammalian disorder of sexual development NR5A1 SOX8 FGFR2 GATA4 CTNNB1 FGF9 WT1 PBX1 MAPK11 SOX9 SRY AMHR2 DHH RSPO1 INSL3 EMX2 RBFOX2 DMRT1 SRD5A1 CBX2 AMH FST PTGDS FOXL2 WNT4 MITOCHONDRIAL FISSION AND FUSION%WIKIPATHWAYS_20260510%WP4318%HOMO SAPIENS Mitochondrial fission and fusion BCL2L1 BNIP3 BAX PHB OPA1 FIS1 MIB1 MTFP1 PLD1 MFN1 MFN2 DNM1L SH3GL2 MICRORNA FOR TARGETING CANCER GROWTH AND VASCULARIZATION IN GLIOBLASTOMA%WIKIPATHWAYS_20260510%WP3593%HOMO SAPIENS MicroRNA for targeting cancer growth and vascularization in glioblastoma VEGFC HIF1AN VEGFA HIF1A HES1 HEY1 VEGFB MAMMARY GLAND DEVELOPMENT INVOLUTION STAGE 4 OF 4%WIKIPATHWAYS_20260510%WP2815%HOMO SAPIENS Mammary gland development involution stage 4 of 4 MMP9 CHI3L1 CDH1 E2F1 TP53 IL6ST SOCS3 STAT3 MYC BAX SIGNAL TRANSDUCTION THROUGH IL1R%WIKIPATHWAYS_20260510%WP4496%HOMO SAPIENS Signal transduction through IL1R IRAK2 IL6 TOLLIP IRAK3 TAB1 MYD88 IL1B IKBKB IL1RN NFKBIA JUN MAP3K1 CHUK IL1RAP TRAF6 MAP3K14 NFKB1 MAP2K6 TGFB2 IL1R1 TGFB3 IFNB1-4 IL1A MAP2K3 RELA MAP3K7 MAPK8 ECSIT TNF IRAK1 TGFB1 MAPK14 CHEMOKINE SIGNALING%WIKIPATHWAYS_20260510%WP3929%HOMO SAPIENS Chemokine signaling CXCL10 CXCL11 ITK CXCL12 CXCL14 PREX1 TIAM2 ELMO1 CCL3L1;CCL3L3;CCL3;CCL18 RASGRP2 GRK1 GRK2 CCR10 CCR1 CXCL9 XCR1 XCL1;XCL2 NFKBIB PLCB1 WASL CCL23;CCL15 CCR9 IKBKB CCR8 VAV2 CXCL5;CXCL6 NFKBIA CCR7 HCK CCR6 CCR4 CCR2 CHUK PIK3CA PF4;PF4V1-1 FGR CXCL2;CXCL3;CXCL1-1 DOCK2 MAPK1 IKBKG CCL11 RAF1 CXCR5 PRKX NFKB1 CXCR6 CCL1 CCL19 CCL17 CXCR2 CCL25 CCL24 CCL22 CCL21 CCL20 STAT2 CCL28 PPBP CCL26 JAK3 PLCB2 PRKCB PRKCD ADCY9 NCF1 VAV3 PRKCZ GRK5 GRK4 GRK6 CXCL13 GNG13 PXN GNB2 GNB1 GNB4 GNB3 GNB5 GNG10 ARRB1 ARRB2 GNGT1 PLCB3 PIK3CD PIK3CB PIK3CG VAV1 AKT2 AKT3 ADCY4 PTK2B JAK2 GNAI3 ADCY3 HRAS ADCY2 ROCK1 ADCY1 ROCK2 ADCY8 WAS ADCY7 PIK3R5 GNAI1 ADCY6 GNAI2 CDC42 ADCY5 PRKACB-1 CSK GNG2 GNG5 GNG4 GNG8 SOS1 SOS2 BCAR1 FOXO3 RAP1A LYN PARD3 STAT5B TIAM1 STAT1 STAT3 KRAS GRB2 SHC1-1 CRKL GSK3B CX3CL1 RAC1 CCL27 AKT1 CRK SHC4 CX3CR1 SHC3 SHC2 PIK3R3 PIK3R2 PIK3R1 NRAS PAK1 PLCB4 RELA RAP1B CXCR4 MAP2K2;MAP2K1 CCL4L2;CCL4L1;CCL4 CCL5 CXCR3 MAPK3 CCR3 BRAF PTK2 FATTY ACID AND LIPOPROTEIN TRANSPORT IN HEPATOCYTES%WIKIPATHWAYS_20260510%WP5323%HOMO SAPIENS Fatty acid and lipoprotein transport in hepatocytes LRP1 APOA4 FABP1 LDLR STAR ACSL1 ACSL3 PCSK9 LIPA VDAC1 LDLRAP1 STARD3 MYLIP SLC27A2 SOAT1 NPC2 SLC27A4 APOE ACSL6 ABCA1 ACSL5 FABP3 FABP4 SOAT2 SLC27A3 APOB OSBPL5 SORT1 FABP2 SLC27A1 APOC2 APOC1 SCARB1 SREBF AND MIR33 IN CHOLESTEROL AND LIPID HOMEOSTASIS%WIKIPATHWAYS_20260510%WP2011%HOMO SAPIENS SREBF and miR33 in cholesterol and lipid homeostasis LDLR PPARGC1A PPARA ABCA1 PRKAA1 SIRT1 MED15 SCD SREBF1 FASN SREBF2 MTOR NR1H3 SIRT6 HMGCR HMGCS1-1 2Q37 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP5224%HOMO SAPIENS 2q37 copy number variation syndrome CXCL11 NEU4 CXCL12 PDCD1 NFKBIA JUN TRAF3IP1 HES6 ABCA1 RRAGA DGKD IQCA1 NDUFA10 HDLBP HJURP ERFE SEPTIN2 KLHL30 IL13RA1 MEF2A MAP1LC3B2;MAP1LC3B-1 GABARAPL2 PASK SEPTIN4-1 EEF1A1 THAP4 RRAGC RRAGB RRAGD CALCA CALCRL TWIST2 AGAP1 GABARAP COPS9-1 COPS8 ESPNL TRPM8 OR6B2 UBE2F MTERF4 RAB27A MYO5A STK25 HAMP ACKR3-2 SNED1 RTP5 GMEB1 SCLY RNPEPL1 ILK SEPTIN12 PRL ITPK1 ING5 GYS1 MAP1LC3C LRRFIP1 KIF1A ILKAP IRF8 BOK HES1 MYOG AQP12B GPR35 DUSP28 OTOS ARL4C UGT1A1;UGT1A6 MYOD1 COL6A3 ATG4B USP40 AGXT ARF5 HDAC4 ASCL1 CALM1 ASB18 CENPA CYTH3 CYTH2 CYTH4 GBX2 PPP1R7 GPC1 SH3BP4 SPP2 D2HGDH PRLH DISC1 CYTH1 FARP2 PDX1 SEPTIN6 CFLAR PER2 MAB21L4 MLPH CAPN10 RAB17 RAMP1 RBM44 ASB1 DTYMK MEF2C TP53 ARF1 EGFR RPS6 TNF TRAF3 IL1B MAP1LC3A RAC1 PDGFA CXCR4 ITGB3 ACUTE MYELOID LEUKEMIA%WIKIPATHWAYS_20260510%WP5293%HOMO SAPIENS Acute myeloid leukemia FLT3 IL3 PIK3CD PIK3CB CEBPA MPO PIM1 PIM2 CCND1 CEBPE TCF7 MYC AKT2 AKT3 TCF7L2 BCL2A1 HRAS IKBKB CHUK PIK3CA MAPK1 IKBKG RAF1 TCF7L1 NFKB1 KIT RARA SOS1 SOS2 PPARD CSF1R LEF1 STAT5A STAT5B CCNA2-1 RUNX1T1 RPS6KB1 RPS6KB2 CCNA1 ZBTB16 STAT3 MTOR PML DUSP6 KRAS GRB2 ITGAM FCGR1A ARAF AKT1 CSF2 PIK3R3 PIK3R2 RUNX1 PIK3R1 EIF4EBP1 NRAS CD14 BAD RELA MAP2K2;MAP2K1 SPI1 MAPK3 JUP GLI1 BRAF PER2 PANCREATIC CANCER SUBTYPES%WIKIPATHWAYS_20260510%WP5390%HOMO SAPIENS Pancreatic cancer subtypes CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CTSV;CTSL SPRR3 AREG ST6GALNAC1 SERPINB3;SERPINB4-1 ANXA8;ANXA8L1 GPR87 KRT20 CST6 LGALS4 TFF3-1 SCEL TSPAN8 VSIG2 SPRR1A;SPRR1B AGR2 AGR3 FAM3D TNS4 CTSE PLA2G10;LOC100652777 FAM83A SPINK4 FGFBP1 S100A2 REG4 KRT7 ANXA10 LEMD1 DHRS9 KRT17 MYO1A PRR15L KRT15 LY6D TFF1 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 KRT6B;KRT6C;KRT6A VGLL1 CLRN3 CDH17 SLC2A1 LYZ-1 EXTRACELLULAR VESICLE MEDIATED SIGNALING IN RECIPIENT CELLS%WIKIPATHWAYS_20260510%WP2870%HOMO SAPIENS Extracellular vesicle mediated signaling in recipient cells HGF TGFBR3 KRAS TGFBR2 CTNNB1 AXIN1 TGFBR1-1 HRAS AKT1 TSPAN8 MFGE8 ERBB2 RAF1 TGFA SMAD2;SMAD3 TGFB2 NRAS SMAD4 TGFB3 MET WNT3A EGFR PROM1 WNT5A DKK4 TGFB1 MTOR APC MRNA PROCESSING%WIKIPATHWAYS_20260510%WP411%HOMO SAPIENS mRNA processing CPSF2-1 NCBP1 PRMT1 PRPF40A PTBP2 PRPF18 HNRNPH1 SNRPA1 HNRNPH2 DNAJC8 HNRNPA1-1 SF3B4 SF3B5 SF3B2 SF3B3 RNMT SFSWAP SRSF1 SFPQ-1 DDX20 CSTF2T PPM1G NXF1 U2AF2 TRA2B SPOP SNRPB2 SNRPG-2 SRSF10 SF3B1 SF3A3 RBM39 SF3A1 HNRNPAB SRSF4-1 RNGTT SF3A2 NUDT21 NCBP2-1 SNRNP40 PHF5A HNRNPA2B1 PABPN1-1 RBMX SMC1A PRMT2 POLR2A DICER1 U2AF1L5;U2AF1 HNRNPU HNRNPR EFTUD2 PTBP1 SNRPD2 SNRPD1 CLP1 PAPOLA SNRPD3 TXNL4A PSKH1 SNRPN METTL3 PRPF4B CDC40 SRRM1 PRPF4 PRPF6 PRPF3 XRN2 SRSF2 SRSF3 CD2BP2 SRSF5 SNRPF SREK1 SRSF6 SRSF7 SNRPA SNRPB SRSF9 TMED10 DHX8 DHX9 DDX1 CSTF3 CSTF2 SNU13 PRPF8 PCBP2 SNRPE-2 DHX38 SRPK2 CPSF4 CPSF1 FUS NONO CPSF3 SUPT5H CLK4 CLK3 CLK2 SRPK1 LSM2 HNRNPL CLK1 HNRNPM LSM7 HNRNPK HNRNPD RNPS1 CLASRP HNRNPC SUGP2 SUGP1 CELF1 CELF2 CELF4 SRP54 YBX1 SNRNP70 DHX15 DHX16 RBM5 RBM17 HISTONE MODIFICATIONS%WIKIPATHWAYS_20260510%WP2369%HOMO SAPIENS Histone modifications KMT5B SMYD3 H4C1 KMT5A H3-3A H4C6 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SETDB1 KMT5C SETD1B SETD1A EED H4-16 SETMAR ASH1L SETD2 AEBP2 SETBP1 EZH1 SUV39H1 EZH2 KMT2E SETD4 SMYD2-1 SUV39H2 KMT2D SETD5 SETD3 KMT2A SMYD5 SETD9 EHMT2 KMT2C SETD6 KMT2B DOT1L SETD7 EHMT1 PRDM2 SET-1 NSD1 SMYD1 SMYD4 MULTIPLE SCLEROSIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260510%WP5540%HOMO SAPIENS Multiple sclerosis mechanism and therapies MS4A1 S1PR1 BTK S1PR3 S1PR4 ITGB1 ITGA4 S1PR5 CREATINE PATHWAY%WIKIPATHWAYS_20260510%WP5190%HOMO SAPIENS Creatine pathway GAMT GATM SLC6A8 OAT CKB THYROID STIMULATING HORMONE TSH SIGNALING%WIKIPATHWAYS_20260510%WP2032%HOMO SAPIENS Thyroid stimulating hormone TSH signaling IGF1R PLCB1 JAK2 GNAI3 ADCY3 CDK4 HRAS ADCY2 GNAI1 PIK3CA GNA13 GNAI2 GNA12 MAPK1 RAF1 GNG2 MAP2K6 MAP2K3 SRC CDK2 RAP1A JAK1 SCRIB STAT1 RPS6 RPS6KB1 RBL2 RPS6KA1 STAT3 MTOR GNAS-1 PDPK1 TSHB AKT1 RAP1GAP MYL12B CGA RALGDS KCNIP3 TSHR APEX1 GNAO1 PIK3R2 PIK3R1 CREB1 GNAQ GNB1 RAP1B CDKN1B PDE4D-1 MAP2K2;MAP2K1 CCND3 CCNE1 RB1 MAPK3 PLD1 BRAF MAPK14 ARYL HYDROCARBON RECEPTOR RESPONSE TO MAIN MEDIATORS PAH AND TCDD%WIKIPATHWAYS_20260510%WP2586%HOMO SAPIENS Aryl hydrocarbon receptor response to main mediators PAH and TCDD CYP1A1 LPL EP300 KRAS CYP1A2 PTGS2-2 MYC HRAS VEGFA AHR ESR1 CD36 MAPK1 HSP90AA1 NFE2L2 RET CYP1B1 RAF1 HPGDS PLAGL1 NFKB1 NRIP1 CCL1 GCLC NCOR2 KLF6 NRAS PSRC1 NQO1 NCOA7 E2F1 AIP ARNT CDC37 SRC CDK2 AHRR RELA FGF21 NF1 EGFR CDKN1B MAP2K2;MAP2K1 TNF RB1 CDKN1A SARS COV 2 B 1 1 7 VARIANT ANTAGONISES INNATE IMMUNE ACTIVATION%WIKIPATHWAYS_20260510%WP5116%HOMO SAPIENS SARS CoV 2 B 1 1 7 variant antagonises innate immune activation MAVS TBK1 TRAF3 IKBKE IFNB1-4 DDX58 TOMM70 IRF3 TRAF6 IL18 SIGNALING%WIKIPATHWAYS_20260510%WP4754%HOMO SAPIENS IL18 signaling PTEN NFATC4 SP1 CTNNB1 PRKAA1 IKBKB GATA1 NFKBIA IRF1 ELAVL1 CHUK TRAF6 ACACB MAPK1 FASLG NFKB1 CASP8 TP53 BID MAP3K7 RPS6KB1 GRIN2B TNF MEF2A PRKCB PRKCD PRKCA IL18 NCF1 NCF2 HSPB1 MYD88 NOX1 GSK3B CASP3 PARP1 PIK3R1 MAP2K7 LCK IL18RAP TICAM2 IMP3 CYCS-1 TNFRSF1A CSN2-1 CEBPB SLC12A3 IL18R1 RELA MAPK9 BAX FAS IRAK1 MAPK3 IL37 CFLAR KLEEFSTRA SYNDROME%WIKIPATHWAYS_20260510%WP5351%HOMO SAPIENS Kleefstra syndrome H3-3A RXRA SMARCC1 SMARCC2 ACTL6B ACTL6A ARID1A ARID1B SMARCA4 PAXIP1 NR1I3 DPY30 ASH2L PAGR1 RBBP5 WDR5 KDM6A SMARCA2 MBD5 NCOA6 ASXL1 KMT2C BAP1 SMARCD1 SMARCD2 SMARCB1 SMARCD3 EHMT1 TARGET OF RAPAMYCIN SIGNALING%WIKIPATHWAYS_20260510%WP1471%HOMO SAPIENS Target of rapamycin signaling RRAGD RPTOR DDIT4 PRKAA1 MLST8 MAPKAP1 RICTOR RAC1 AKT1 TSC2 TSC1 CDC42 AKT1S1 EIF4EBP1 ULK2 PRKAB2 PRKAB1 PRKAA2 IDI1 FKBP1A RRAGA ULK1 PRKAG1 PRKAG2 RPS6KB1 PRKAG3 PRR5 DDIT4L ULK3 PRKCA PRR5L MTOR HMGCR RRAGC RHEB RRAGB GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260510%WP661%HOMO SAPIENS Glucose homeostasis INS;INS-IGF2 NUCLEOTIDE EXCISION REPAIR%WIKIPATHWAYS_20260510%WP4753%HOMO SAPIENS Nucleotide excision repair RAD23A PCNA GTF2H1 ERCC5;BIVM-ERCC5 GTF2H3 GTF2H4 RAD23B CUL4A RBX1 DDB1 ERCC3 ERCC4 ERCC1 ERCC2 ERCC8 MNAT1 CUL4B POLE4 POLE RFC5 RFC3 DDB2 RFC4 POLE3 ERCC6 POLD4 POLD1 POLD3 POLD2 CDK7 RPA1 RPA2 CCNH RPA3 POLE2 GTF2H2C;GTF2H2C_2;GTF2H2 CETN2 XPA XPC RFC1 LIG1 RFC2 TRANSCRIPTION FACTOR REGULATION IN ADIPOGENESIS%WIKIPATHWAYS_20260510%WP3599%HOMO SAPIENS Transcription factor regulation in adipogenesis CREB1 LEP IL6 RXRA CEBPA CEBPD PPARGC1A CEBPB SLC2A4 IRS2 IRS1 LPIN1 NR3C1 MAPK8 TNF INSR FOXO1-1 PCK2 PPARG ADIPOQ NRIP1 NRF2 ARE REGULATION%WIKIPATHWAYS_20260510%WP4357%HOMO SAPIENS NRF2 ARE regulation AIMP2 HMOX1 GCLM NQO1 KEAP1 MAF FYN RBX1 CEBPB SRC GSTA3;GSTA5;GSTA1;GSTA2 EPHB2 GSK3B CUL3 MAPK8 PGAM5 YES1 INSR PIK3CA PRKCA NFE2L2 SLC7A11 GCLC LTF DANGER SIGNAL RESPONSE PATHWAY%WIKIPATHWAYS_20260510%WP4478%HOMO SAPIENS LTF danger signal response pathway IL6 IFNB1-4 IL1A TLR4 TLR2 TREM1 CD14 MYD88 IL1B CXCL8 IRAK4 AGER LTF TNF IRAK1 TRAF6 MAPK1 NFKB1 TARGETED THERAPY IN BREAST CANCER%WIKIPATHWAYS_20260510%WP5496%HOMO SAPIENS Targeted therapy in breast cancer KRAS PIK3CD PIK3CB PIK3CG AKT2 AKT3 PIK3R4 PIK3C2G PIK3C2A HRAS PIK3R6 AKT1 PIK3C2B PIK3R5 PIK3CA ERBB2 MAPK1 RAF1 PIK3R3 PIK3R2 ERBB3 PIK3R1 NRAS ERBB4 EGFR MAPK3 IL23 INHIBITORS IN INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260510%WP5516%HOMO SAPIENS IL23 inhibitors in inflammatory bowel disease IFNG IL23A TLR4 STAT5A STAT5B IL22 STAT1 JAK2 RORC TNF STAT4 CSF2 IL17F IL12RB1 IL17A STAT3 IL12B TYK2 TYPE I COLLAGEN SYNTHESIS IN THE CONTEXT OF OSTEOGENESIS IMPERFECTA%WIKIPATHWAYS_20260510%WP4786%HOMO SAPIENS Type I collagen synthesis in the context of osteogenesis imperfecta ITPR1 FKBP10 PLOD2 TNFRSF11B MIA3 TNFRSF11A PLOD1 ADAMTS2 SERPINH1 TNFSF11 TMEM38B COLGALT1 IFITM5 MBTPS1 CRTAP SERPINF1 P3H2 P3H1 COL1A2 BMP1 LOX CREB3L1 P4HA1 P4HA2 LRP5 P4HB SP7 PPIB LRP6 COL1A1 MBTPS2 WNT1 FZD1 MITOCHONDRIAL LONG CHAIN FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260510%WP368%HOMO SAPIENS Mitochondrial long chain fatty acid beta oxidation CPT2 SCP2 ACADM ACSL1 ACSL4 ACSL3 PECR ACADVL ECI1 ACSF2 HADHA ACADL SLC25A20 CPT1A HADH EHHADH-1 ACADS FOLATE METABOLISM%WIKIPATHWAYS_20260510%WP176%HOMO SAPIENS Folate metabolism GPX4 IL2 ICAM1 LDLR MPO F2 SERPINE1 CRP HBD;HBB HBA2;HBA1 NFKB2 INS;INS-IGF2 MTRR NFKB1 MTR-1 TP53 ABCA1 TNF SHMT1 INSR SERPINA3 SLC46A1 SAA2;SAA1 CBS;CBSL APOA1 FLAD1 RFK FGB FGA GPX1 SAA2-SAA4;SAA4 IL6 FGG GPX6 IZUMO1R F7 PLG SLC19A1 ALB FOLR2 IL1B FOLR1 SHMT2 SOD2 CTH PLAT CAT CSF1 DHFR2;DHFR ST20-MTHFS;MTHFS IFNG SOD3 RELA MTHFR MAT1A CCL13;CCL2 MTHFD1 APOB MTHFD2 GART IL4 AHCY SOD1 SCARB1 IL1 SIGNALING%WIKIPATHWAYS_20260510%WP195%HOMO SAPIENS IL1 signaling IRAK2 IRAK3 TAB1 ATF2 NFKBIB IRAK4 IKBKB NFKBIA JUN MAP3K1 CHUK TRAF6 MAPK1 IKBKG MAP3K14 NFKB1 MAP2K6 MAP2K3 MAP3K7 ECSIT TAB2 REL TOLLIP MYD88 IL1B HSPB2 PELI1 UBE2V1 SQSTM1 PELI2 MAP2K4 MAP3K2 PRKCZ MAP3K3 UBE2N TAB3 AKT1 IL1RAP MAPKAPK2 PIK3R2 PIK3R1 MAP2K7 IL1R1 IL1A RELA PTPN11 MAPK9 MAPK8 MAP2K2;MAP2K1 IRAK1 PLCG1 MAPK3 MAPK14 STEROID HORMONE PRECURSOR BIOSYNTHESIS%WIKIPATHWAYS_20260510%WP5277%HOMO SAPIENS Steroid hormone precursor biosynthesis CYP21A2 CYP11A1 SRD5A2 SRD5A1 HSD3B1;HSD3B2 CYP17A1 AKR1D1 PHYSIOLOGICAL AND PATHOLOGICAL HYPERTROPHY OF THE HEART%WIKIPATHWAYS_20260510%WP1528%HOMO SAPIENS Physiological and pathological hypertrophy of the heart MAPK11 NFATC4 MAP2K3 GATA4 CAMK2D CALM1 MAPK8 RAC1 EDN1 MYEF2 JUN CTF1 PRKCB LIFR PRKCE PPP3CB IL6ST STAT3 MAPK1 PPP3CA MAPK14 FOS AGT RHOA HIPPOCAMPAL SYNAPTOGENESIS AND NEUROGENESIS%WIKIPATHWAYS_20260510%WP5231%HOMO SAPIENS Hippocampal synaptogenesis and neurogenesis CAMK2B BCL2 CAMK2A PRL NRXN3 NRXN2 MAPK1 CAMKK1 CAMKK2 SYT2 NRXN1;NRXN3;NRXN2 SYT12 RPS6KA5 CREB1 NGF PPARGC1A BDNF HNRNPL CALM1 CAMK4 NCAM1 RPS6KA1 DRD1 PRKCA CCND2 MAPK14 LDL INFLUENCE ON CD14 AND TLR4%WIKIPATHWAYS_20260510%WP5272%HOMO SAPIENS LDL influence on CD14 and TLR4 MAPK11 REL CREB1 IL6 TLR4 CD14 CREB3L3 RELB CREB3L4 IL1B RELA CREB3L1 CREB3L2 CCL13;CCL2 CREB3 MAPK13 ATF4 CREB5 NFKB2 IL10 MAPK14 NFKB1 MAPK12 CARNOSINE METABOLISM OF GLIAL CELLS%WIKIPATHWAYS_20260510%WP5313%HOMO SAPIENS Carnosine metabolism of glial cells SLC6A6 SLC15A2 CARNS1 SLC15A4 VITAMIN D IN INFLAMMATORY DISEASES%WIKIPATHWAYS_20260510%WP4482%HOMO SAPIENS Vitamin D in inflammatory diseases SMAD4 IL6 VDR RXRA DUSP1 PPP3R1 MAP2K3 MED14 RELA NFATC1 NR3C1 IKBKB TNF NFKBIA MAP3K1 CHUK PPP3CA IKBKG MAPK14 NFKB1 SMAD2;SMAD3 MAP2K6 HEROIN METABOLISM%WIKIPATHWAYS_20260510%WP2645%HOMO SAPIENS Heroin metabolism BCHE CES2 CES1 THERMOGENESIS%WIKIPATHWAYS_20260510%WP4321%HOMO SAPIENS Thermogenesis DPF1 DPF3 SMARCE1 SMARCC1 SMARCC2 ACTL6B ACTL6A ARID1A ARID1B PRKAA1 SMARCA4 KDM1A PRKAB2 PRKAB1 PPARGC1A MAP2K3 CREB3L3 ACSL6 CREB3L4 ACSL5 CREB3L1 CREB3L2 CREB3 PRKAG1 PRKAG2 PRKAG3 RPS6KA3 CREB5 GNAS-1 ADCY9 ACTG1 FGF21 SMARCA2 MAPK13 ACTB-1 PRKACA-1 ADRB3 RPTOR ACSL1 ATF2 ACSL4 ACSL3 MLST8 ADCY4 ADCY3 HRAS ADCY2 ADCY1 ADCY8 ADCY7 TSC2 TSC1 PRDM16 ADCY6 ADCY5 PRKACB-1 PPARG AKT1S1 MAPK12 MAPK11 SOS1 SOS2 RPS6 RPS6KB1 RPS6KB2 RPS6KA1 SLC25A20 CPT1A MTOR SIRT6 RHEB KRAS GRB2 CPT2 FGFR1 CNR1 GCG MAP3K5 CREB1 NRAS PRKAA2 KLB LIPE RPS6KA6 RPS6KA2 BMP8A;BMP8B FRS2 CPT1C CPT1B NPR1 ADCY10 PRKG2 PRKG1 ZNF516 SMARCD1 PLIN1 SMARCD2 SMARCB1 MGLL KDM3A SMARCD3 KDM3B UCP1 SLC25A29 MAPK14 BMP8B PNPLA2 NUCLEAR RECEPTORS%WIKIPATHWAYS_20260510%WP170%HOMO SAPIENS Nuclear receptors RARG NR5A1 THRB NR1I2 NR2E1 RXRB RXRA NR4A2 HNF4A NR4A1 RXRG PGR ESRRB NR2F1 PPARA NR1H2 NR1D2 NR0B1 NR5A2 NR2F2 RARB RORC NR2F6 ROR1 RORA ESR1 ESRRA PPARG NR2C2 RARA VDR PPARD NR1I3 NR3C1 THRA AR NR1H3 ESR2 AKT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260510%WP5531%HOMO SAPIENS AKT signaling and ARTD family members PIK3CD STK11 PIK3CB PIK3CG RPTOR GSK3B PHLPP1 AKT2 AKT3 PARP3 MLST8 PARP2 SIRT1 MAPKAP1 PIK3R4 PIK3C2G PIK3C2A RICTOR PIK3R6 AKT1 PIK3C2B PIK3R5 TSC2 TSC1 PIK3CA FOXO1-1 IKBKG PARP1 PIK3R3 PIK3R2 PIK3R1 PDK1 ATM MTOR NEPHROTOXCICITY ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260510%WP5229%HOMO SAPIENS Nephrotoxcicity adverse outcome pathway SLC22A2 SLC31A1 GASTRIC ACID PRODUCTION%WIKIPATHWAYS_20260510%WP2596%HOMO SAPIENS Gastric acid production GRP PGA4;PGA3;PGA5 SCT PGC MUC6 VIP CCK GAST CBLIF T CELL ANTIGEN RECEPTOR TCR PATHWAY DURING STAPHYLOCOCCUS AUREUS INFECTION%WIKIPATHWAYS_20260510%WP3863%HOMO SAPIENS T cell antigen receptor TCR pathway during Staphylococcus aureus infection IL2 ITK CTLA4 FYN NFATC2 CD8A CD28 PTPN6 PDCD1 CDK4 IKBKB NFKBIA GRAP2 JUN DAG1 RRAS CHP1 CHUK PIK3CA MAP3K8 AHSA1 ZAP70 IKBKG LCP2 RAF1 CARD11 BCL10 MAP3K14 MALT1 NFKB1 ICOS DLG1 CD40LG SOS1 IL5 PTPRC PDK1 MAP3K7 TNF GRB2 PRKCQ GSK3B NCK1 AKT1 CSF2 CD3D FOS CBL IFNG MAP2K7 LCK PAK1 CALM1 MAPK9 MAP2K2;MAP2K1 IL4 CD4 PLCG1 MAPK3 IL10 LAT TROP2 REGULATORY SIGNALING%WIKIPATHWAYS_20260510%WP5300%HOMO SAPIENS TROP2 regulatory signaling CHEK1 PTEN IGF1R CCND1 CDKN2A IGF1 BCL2 CTNNB1 CLDN1 NOTCH1 JAK2 CDH1 CDK4 RAC1 JUN NFKB1 PIK3R1 ACVRL1 PSEN2 TACSTD2 MDK MMP13 RACK1 PAK4 ABCC1 IGF2 ITGB1 IGF2R SRC CDK2 CLDN7 PECAM1 ITGA5 FN1 VIM TLN1 EGFR BAX CDKN1B STAT1 CCNE1 RB1 PRKCD PRKCA PTK2 MIRNA REGULATION OF P53 PATHWAY IN PROSTATE CANCER%WIKIPATHWAYS_20260510%WP3982%HOMO SAPIENS miRNA regulation of p53 pathway in prostate cancer CASP8 PTEN BID TP53 MDM2-2 SERPINE1 SIAH1 BAX SHISA5 CYS1 CASP9 PMAIP1 EI24-1 SESN3 ZMAT3 CASP3 PERP ATM TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A DDB2 APAF1 CHEK2 BBC3 DISORDERS OF NAD METABOLISM%WIKIPATHWAYS_20260510%WP5506%HOMO SAPIENS Disorders of NAD metabolism BST1 NAXE NAXD NADSYN1 CD38 DNAJB1 PRKACA FUSION IN FIBROLAMELLAR LIVER CANCER%WIKIPATHWAYS_20260510%WP5514%HOMO SAPIENS DNAJB1 PRKACA fusion in fibrolamellar liver cancer CREB1 HDAC5 HDAC4 DNAJB1 PRKACA-1 CRTC2 SIK3 GNAS-1 SIK1;SIK1B SIK2 HDAC7 EFFECTS OF NITRIC OXIDE%WIKIPATHWAYS_20260510%WP1995%HOMO SAPIENS Effects of nitric oxide MB AOX1 NOS1 HBD;HBB XDH HBA2;HBA1 NOS3 NOS2 NON SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260510%WP4255%HOMO SAPIENS Non small cell lung cancer HGF PIK3CD RXRB PIK3CB RXRG CCND1 CDKN2A RARB AKT2 AKT3 CDK6 CDK4 HRAS PIK3CA ERBB2 MAPK1 RAF1 KIF5A CASP8 SOS1 SOS2 MET TP53 BID FOXO3 STAT5A EGFR STAT5B JAK3 PRKCG PRKCB PRKCA STAT3 RASSF1 KRAS GRB2 ALK RXRA KIF5C RASSF5 KIF5B EML4 CRABP2 CRABP1 STK4 ARAF FHIT CASP9 PDPK1 CASP3 POLK AKT1 DDB2 RET TGFA NRAS E2F1 CYCS-1 E2F2 E2F3 EGF BAK1 GADD45B BAD GADD45A GADD45G BAX MAP2K2;MAP2K1 PLCG2 PLCG1 RB1 MAPK3 BRAF CDKN1A COMPLEMENT ACTIVATION%WIKIPATHWAYS_20260510%WP545%HOMO SAPIENS Complement activation C7 C1S C9 C1R LOC110384692;C4A;C4B_2;C4B C8B C8A CD55 C8G C3-1 MASP2 MASP1 CFB C1QC CFD C1QB CFP C2 C5 C6 IL4 SIGNALING%WIKIPATHWAYS_20260510%WP395%HOMO SAPIENS IL4 signaling EP300 PIK3CD CEBPA ATF2 PTPN6 IRS2 IRS1 JAK2 IKBKB NFKBIA CHUK PIK3CA MAPK1 NFKB1 MAPK11 SOS1 JAK1 IL2RG STAT5A STAT5B JAK3 STAT1 RPS6KB1 GAB2 STAT3 INPP5D GRB2 SHC1-1 DOK2 FLNA SOCS5 ELK1 FES AKT1 IL4R FOS TYK2 CBL PIK3R2 PIK3R1 CEBPB SOCS3 BAD RELA PTPN11 STAT6 IL4 SOCS1 MAPK3 MAPK14 TAR SYNDROME%WIKIPATHWAYS_20260510%WP5362%HOMO SAPIENS TAR syndrome FLT3 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E DDIT4 POLR3GL POLR3C NFKB1 POLR3F POLR3G MET CD160 EGFR STAT3 HDAC2 SIRT1 HAMP ANKRD35 EIF4A3 CCAR2 SLC22A12 SLK HJV SUMO2 PIAS3 CD3D PDZK1 AKAP10 DNM1 RBCK1 SLC22A4 CFTR GPR89A;GPR89B PEX11B FURIN TXN IFNG CLCN3 BCL2L13 LCK SLC9A3R1 MTA1 TNFRSF14 MAGOH;MAGOHB ZFHX3 PEX19 ITGB1 UBE2I BRF1 PYM1 PDZK1IP1 ITGA10 MITD1 CXCR4 LAMTOR1 CD247 FARP2 SYNTHESIS OF CERAMIDES AND 1 DEOXYCERAMIDES%WIKIPATHWAYS_20260510%WP5194%HOMO SAPIENS Synthesis of ceramides and 1 deoxyceramides CERS1 CERS2 B4GALNT1 SPTLC1 CERS3 CERS4 CERS5 ASAH1 CERS6 B4GALT1 CERK SGMS1 SPHK1 SGMS2 UGT8 UGCG DES B3GNT5 KDSR A4GALT DGAT1 A3GALT2 GENES TARGETED BY MIRNAS IN ADIPOCYTES%WIKIPATHWAYS_20260510%WP1992%HOMO SAPIENS Genes targeted by miRNAs in adipocytes HCN4 KCNQ1 HAND2 ERG PTBP2 KCNE1;KCNE1B HCN2 KCNJ2 GJA1 IGF1 HDAC4 SRF ANDROGEN RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP138%HOMO SAPIENS Androgen receptor signaling EP300 PTEN SMARCE1 RNF14 TGFB1I1 SP1 FHL2 CCND1 UBE3A CTNNB1 PARK7 EFCAB6 KAT5 SUMO1 BRCA1 ZMIZ1 RAN TGIF1-1 PIAS4 DAXX NCOA3 CREBBP NCOA4 ROCK1 PIAS2 ROCK2 PIAS1 JUN TLE5 KAT2B FOXO1-1 NCOR1 CDC42 ZNF318 CAV1 KDM1A FKBP4 RNF6 RNF4 NR2C2 PRDX1 BAG1 SMAD2;SMAD3 RLN2;RLN1 PATZ1 SMAD4 LIMK2 CALR-1 DSTN NR0B2 STUB1 RACK1 SMIM40 RAD9A SRC MDM2-2 EGFR STAT3 HDAC1 BUB1B-PAK6;PAK6 PSMC3IP GSK3B FLNA SIRT1 RAC1 SIN3A AKT1 PIAS3 RHOB NCOA2 ETV5 RHOA PIK3R2 NCOR2 PIK3R1 CREB1 NCOA1 UBE2I RELA CARM1 CCNE1 RB1 RUNX2 AR PTK2 MTHFR DEFICIENCY%WIKIPATHWAYS_20260510%WP4288%HOMO SAPIENS MTHFR deficiency GRIN2A DNMT1 PEMT CYCS-1 PCYT1A GRIN2D CHKA DNMT3B DNMT3A MARS1 ASMT MTHFR HNMT BHMT NDUFAF7 CHPT1 ALDH7A1 CASP9 CHDH EHMT2 COMT CASP3 GRIN1 EHMT1 FLT3 P GLN640SERFSTER8 SIGNALING%WIKIPATHWAYS_20260510%WP5431%HOMO SAPIENS FLT3 p Gln640SerfsTer8 signaling CCR5 FLT3 CCR6 STAT3 DEVELOPMENT OF PULMONARY DENDRITIC CELLS AND MACROPHAGE SUBSETS%WIKIPATHWAYS_20260510%WP3892%HOMO SAPIENS Development of pulmonary dendritic cells and macrophage subsets IRF4 BATF3 TCF4 FLT3LG IKZF1 TPO ID2-1 SPI1 CSF2 RUNX2 CSF1 STAT3 IRF8 CYTOKINES AND INFLAMMATORY RESPONSE%WIKIPATHWAYS_20260510%WP530%HOMO SAPIENS Cytokines and inflammatory response IL2 IL3 IL6 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 IL1B IL13 CSF3 IL7 CSF2 CSF1 CXCL2;CXCL3;CXCL1-1 IL12B IFNG IL5 IFNB1-4 IL1A PDGFA IL4 CD4 TNF IL11 HLA-DRA IL10 TGFB1 IL15 11P11 2 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260510%WP5348%HOMO SAPIENS 11p11 2 copy number variation syndrome TIMP1 TP53 LEF1 HLA-DRA LGALS3BP CD82 SPPL2C ACCS ALKBH3 NDST1 C11orf96 C11orf94 LARGE2 CD53 CHST6 ITGA3 SLC35C1 MAPK8IP1 SLC25A17 CD63 B3GNT7 PRDM11-1 PEX3 CHST1 ITGB2 ITGA6 B4GALT4 IGSF8 CD151 REST PHF21A SDCBP MS4A1 HLA-DMB CD19 ALX4 TP53I11 PEX16 SYT13 EXT1 VANGL1 EXT2 B4GAT1 HBEGF TSPAN18 IZUMO1-1 CRY2 NRXN1;NRXN3;NRXN2 CLOCK ITGB1 ARNTL HLA-DMA SHH CD4 ITGA4 GLI3 TYPE I INTERFERON INDUCTION AND SIGNALING DURING SARS COV 2 INFECTION%WIKIPATHWAYS_20260510%WP4868%HOMO SAPIENS Type I interferon induction and signaling during SARS CoV 2 infection ACE2 MAVS IFIH1 TBK1 IKBKE TRAF3 DDX58 MYD88 IRF3 IRF7 TLR7 TLR3 IRAK4 IFNAR2 TRAF6 EIF2AK2 OAS1 TYK2 TREML4 OAS3 TLR9 IFNAR1 TLR6 IRF9 TLR4 TLR2 STAT2 JAK1 STAT1 TMPRSS2 ROS IN COVID 19 ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260510%WP5258%HOMO SAPIENS ROS in COVID 19 endothelial dysfunction ACE2 IFNAR1 ICAM1 TNF TNFRSF1A NOX1 NFKB1 BRAIN DERIVED NEUROTROPHIC FACTOR BDNF SIGNALING%WIKIPATHWAYS_20260510%WP2380%HOMO SAPIENS Brain derived neurotrophic factor BDNF signaling FYN CTNNB1 PRKAA1 IKBKB VAV2 NFKBIA EIF4E JUN MAP3K1 CHUK ACACB TRAF6 MAPK1 IKBKG RAF1 RAB3A GRIP1 NFKB1 RPS6KA5 DLG1 RACK1 MAP2K5 BDNF GABRB3 RPS6KA3 MEF2A PRKCD SH2B2 NCF1 NCF2 VAV3 RASGRF1 CFL1 RANBP9 SORT1 PPP2CB;PPP2CA NFATC4 MEF2C CAMK2A IRS2 IRS1 PTK2B JAK2 HRAS KSR1 TSC2 CDC42 NSF GRIA1 GRIA2 FOXO3 SRC RAP1A STAT5A CAMK4 STAT5B TIAM1 CAMK1 STAT1 RPS6 NTRK1 RPS6KB1 NGFR GRIN2B NTRK2 GRIN1 RPS6KA1 MAPT STAT3 MTOR CYFIP1 APC GRB2 SHC1-1 CNR1 GSK3B SQSTM1 NCK2 NCK1 ELK1 MAP3K2 PDPK1 RAC1 CASP3 AKT1 SHC4 SHC3 SHC2 PIK3R2 PIK3R1 EIF4EBP1 CREB1 CRTC1 NGF CDH2 DPYSL2 CDKL5 ADAM17 FRS3 DOK5 PRKAA2 MAPK10 SIRPA;SIRPB1;SIRPG KCNN2 BAD GRIA3 RELA EIF2S2 PTPN11 EEF2 EIF2S1 CDK5 MAPK9 FRS2 DOCK3 NCAM1 PTPRF MAPK8 RHOG MAP2K2;MAP2K1 SYN1 CSNK2A1;CSNK2A3 PLCG1 KCNA3 MAPK7 MAPK3 NTF3 IGF2BP1 SH2B1 YBX1 LINGO1 KIDINS220 NTRK3 MAPK14 MARCKS CDK5R1 UREA CYCLE AND METABOLISM OF AMINO GROUPS%WIKIPATHWAYS_20260510%WP497%HOMO SAPIENS Urea cycle and metabolism of amino groups CKM ARG1 GLUD1;GLUD2 ODC1 PYCR3 ASS1 SRM SMS SARDH ASL NAGS ALDH18A1 GAMT GATM ARG2 CPS1 OTC OAT PYCR1 CKB ACY1;ABHD14A-ACY1 NEPHROGENESIS%WIKIPATHWAYS_20260510%WP5052%HOMO SAPIENS Nephrogenesis BMP7 FGF20 FOXD1 WNT3A OSR1 GREB1L NOTCH2 TCF21 PAX2 MEIS1 SIX2 RSPO1 ALDH1A2 FGF8 RSPO3 JAG1 WNT9B WNT4 EIF5A REGULATION IN RESPONSE TO INHIBITION OF THE NUCLEAR EXPORT SYSTEM%WIKIPATHWAYS_20260510%WP3302%HOMO SAPIENS eIF5A regulation in response to inhibition of the nuclear export system XPO1 XPO4 EIF5A;EIF5AL1 IGF2BP1 KISSPEPTIN KISSPEPTIN RECEPTOR SYSTEM IN THE OVARY%WIKIPATHWAYS_20260510%WP4871%HOMO SAPIENS Kisspeptin kisspeptin receptor system in the ovary MMP9 KRAS PLCB3 PIK3CD PIK3CB FSHR PRKCQ PIK3CG HSD3B1;HSD3B2 STAR AKT2 PLCB1 HRAS AKT1 KISS1R KISS1 PIK3CA MAPK1 RAF1 NFKB1 NRAS GDF9 PLCB4 PDK1 MAP2K2;MAP2K1 CYP11A1 PLCB2 BMP15-1 PRKCG ARRB1 MAPK3 PRKCH ARRB2 AMH PRKCB PRKCE PRKCD PRKCA CONGENITAL GENERALIZED LIPODYSTROPHY%WIKIPATHWAYS_20260510%WP5101%HOMO SAPIENS Congenital generalized lipodystrophy GRB2 FYN HIF1A AKT2 IRS1 LPIN1 DGAT2 INS;INS-IGF2 PIK3CA CAVIN1 ITGB4 CAV1 AGPAT2 BSCL2 GPAT3 LPIN2 DGAT1 LPIN3 SELECTIVE EXPRESSION OF CHEMOKINE RECEPTORS DURING T CELL POLARIZATION%WIKIPATHWAYS_20260510%WP4494%HOMO SAPIENS Selective expression of chemokine receptors during T cell polarization IL2 CCL3L1;CCL3L3;CCL3;CCL18 CD28 CCR1 CCR7 CSF2 IL12RB1 CCR4 CCR2 IL4R IL12B IFNGR1 IL12A IL12RB2 TGFB2 IFNGR2 CD40LG IFNG TGFB3 IL5 IL18R1 CXCR4 CCR5 IL4 CCL4L2;CCL4L1;CCL4 CD4 CXCR3 TGFB1 CCR3 UROTENSIN II MEDIATED SIGNALING%WIKIPATHWAYS_20260510%WP5158%HOMO SAPIENS Urotensin II mediated signaling UTS2R EP300 PTEN ICAM1 BCL2 CTNNB1 DDIT3 CAMK2A JAK2 CREBBP IKBKB CHUK MAPK1 NFKB1 SMAD2;SMAD3 NPPB AIFM2 NPPA TRPC4 ACTA2 GSK3A FSCN1 HSPA2 NOX4 ABCA1 CDK2 CDK1 EGFR AGTR1 TNF ESPL1 STAT3 MMP2 MMP9 PCNA HMOX1 NCF1 IL6 NCF2 NCF4 IRF3 IL1B GSK3B CYBB CYBA CASP9 CASP3 AKT1 RHOA COL2A1 RELA PTPN11 FN1 MAPK9 BAX COL1A1 MAPK8 COL3A1 CCNE1 HDAC5 MAPK3 TGFB1 ALOX5 VCAM1 PRKACA-1 MAPK14 PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20260510%WP98%HOMO SAPIENS Prostaglandin synthesis and regulation PTGS2-2 PTGS1 ANXA8;ANXA8L1 TBXAS1 EDN1 MITF PRL ANXA2 PPARGC1B HPGDS PPARG SOX9 PPARGC1A PTGER4 PTGFR AKR1B1 PTGIR PTGER1 HSD11B1 PTGER2 HSD11B2 PTGER3 EDNRA EDNRB PTGFRN S100A10 ABCC4 PTGIS ANXA1 HPGD CYP11A1 TBXA2R ANXA3 ANXA4 ANXA5 PLA2G4A SCGB1A1 S100A6 CBR1-1 PTGES PTGDS ANXA6 PTGDR EVOLOCUMAB MECHANISM TO REDUCE LDL CHOLESTEROL%WIKIPATHWAYS_20260510%WP3408%HOMO SAPIENS Evolocumab mechanism to reduce LDL cholesterol PCSK9 LDLR AMPK REGULATION OF MAMMARY MILK PROTEIN SYNTHESIS%WIKIPATHWAYS_20260510%WP5492%HOMO SAPIENS AMPK regulation of mammary milk protein synthesis PRKAB2 PRKAB1 EEF2K PRKAA2 RPTOR CSN2-1 EEF2 PRKAA1 MLST8 PRKAG1 PRKAG2 RPS6KB1 PRKAG3 EIF4E TSC2 EIF4A2 MTOR CSN3 CSN1S1 EIF4G1 DISORDERS OF GALACTOSE METABOLISM %WIKIPATHWAYS_20260510%WP5173%HOMO SAPIENS Disorders of galactose metabolism PYGL GYS2 GALE GYG2 GYG1 PGM1 GALK1 GALT AKR1B1 SLC5A1-1 SLC2A2 GYS1 GBE1 GLYCINE METABOLISM%WIKIPATHWAYS_20260510%WP1495%HOMO SAPIENS Glycine metabolism SHMT1 MTHFR SHMT2 DNA IR DAMAGE AND CELLULAR RESPONSE VIA ATR%WIKIPATHWAYS_20260510%WP4016%HOMO SAPIENS DNA IR damage and cellular response via ATR CHEK1 MSH2 CDC25C SMARCC2 SP1 BRCA1 PRKDC FANCI IKBKG FANCA RFWD3-2 PLK1 TP53 RAD9A CDK2 MDM2-2 CDK1 ATR SMC1A EXO1 PML MCM2 PCNA MDC1 BCL6 RNF8 CDC45 DCLRE1A SMARCAL1 FEN1 CEP164 FOXM1 WRN UBE2D3-1 POLB HERC2 UIMC1 TOPBP1 UPF1 RECQL TRIM28 HUS1 FANCD2 RMI1 EEF1E1 TOP3A MCPH1 ABRAXAS1 MLH1 BRCC3 PPM1D BRIP1 RECQL5 PARP1 RBBP8 USP1 CLSPN MRE11 TP53BP1 BRCA2 ATRIP POLN XRCC5 PALB2 RAD50 SEM1 RAD51 E2F1 TDP1 RAD17 NBN RAD1 CLK2 BARD1 RPA1 RPA2 RAD52 ATM XPA CHEK2 CANCER PATHWAYS%WIKIPATHWAYS_20260510%WP5434%HOMO SAPIENS Cancer pathways ITGAV RXRB RASGRP1 RXRG CDKN2A PTCH1 RARB CUL2 ELOC-1 CDK6 ELOB SMO MMP1 CDK4 EGLN1 IKBKB EGLN3 EGLN2 COL4A2 NFKBIA BIRC5 CHUK BIRC3 TRAF6 BIRC7 MAPK1 IKBKG RAF1 NOS2 NFKB1 RPS6KA5 IGF2 PRKCG PRKCB PRKCA GNAS-1 ADCY9 ALK RASSF5 EML4 MGST1 GNG13 IL12B HES1 IL12A NCOA1 NQO1 GNAQ GNB2 ARNT GNB1 GNB4 GNB3 GSTA3;GSTA5;GSTA1;GSTA2 GNB5 SPI1 HSP90B1 GNGT1 PRKACA-1 BMP2 WNT4 ITGA2 PLCB3 CEBPA MECOM CTNNA1 CAMK2B CAMK2D CAMK2A ADCY4 GNAI3 PMAIP1 ADCY3 ADCY2 NCOA3 ADCY1 EDN1 NCOA4 JAG1 ADCY8 ADCY7 GNAI1 ADCY6 GNAI2 ADCY5 GSTT2B;GSTT2 PRKACB-1 GNG2 PPARG GSTM1;GSTM2-1 GNG5 GSTA3;GSTA1 GNG4 GNA11 GNG8 CAMK2G IL5 FLT3LG AGT ITGA3 IL6 TRAF3 ITGA6 GSK3B CXCL8 ELK1 CASP9 CASP3 AKT1 HSP90AA1 FOS RHOA XIAP CYCS-1 RELA MAPK9 MAPK8 MAP2K2;MAP2K1 PLCG2 FAS PLCG1 MAPK3 TGFB1 JUP BRAF PTK2 IL2 SP1 BCL2 CTNNB1 JUN IFNAR2 ESR1 PIK3CA TRAF2 TCF7L1 TRAF5 IL12RB2 IFNAR1 IFNGR2 STAT2 EDNRA EDNRB AGTR1 PLCB2 HMOX1 TXNRD3 TXNRD2 TXNRD1 TFG BCR CTBP2 GSTM4 GSTM3 HEY2 APPL1 GSTO2 PAX8 GSTP1 HEYL CSF3R ITGA2B TPM3 PGF MSH3 NOTCH3 MAX NOTCH4 KNG1 TPR HSP90AB1 NKX3-1 CDKN1A PLEKHG5 TRAF1 FLT3 TRAF4 HGF MSH2 FLT4 CCDC42 PTEN HHIP PIK3CD FRAT2 PIK3CB MGST3 MGST2 LPAR2 IGF1R LPAR3 KLK3;KLK2 LPAR4 LPAR5 CCND1 LPAR6 MYC RALBP1-1 AKT2 MST1 AKT3 KIF7 CTNNA3 CTNNA2 JAK2 ARNT2 VEGFD IL6R HRAS GSTA4 F2RL3 PDGFRB FH ETS1 PDGFRA RALA-1 COL4A1 COL4A4 FOXO1-1 COL4A3 COL4A6 AXIN2 COL4A5 CSF2RA RASGRP4 PLD2 KIT RASGRP3 RARA PTCH2 IL7R SOS1 LAMC3 SOS2 LAMC2 MET CKS1B TP53 ARHGEF11 ARHGEF12 DCC PPARD PTGER4 MMP3 CSF1R RALB LAMA2 PTGER1 MDM2-2 LAMA1 PTGER2 LAMA4 LEF1 LRP5 PTGER3 LAMA3 HES5 EGFR LPAR1 LAMB3 LRP6 LAMB2 WNT1 LAMB4 RUNX1T1 LAMB1 NTRK1 ZBTB16 FZD6 STAT3 MTOR PML SLC2A1 APC KRAS GRB2 FGFR4 FGFR3 FGFR2 FGFR1 CALML6 ARAF CALML3 CALML4 JAG2 CDH1 DLL1 RAC1 POLK DLL3 DLL4 MITF DDB2 PIK3R3 PIK3R2 PIK3R1 NRAS E2F1 E2F2 E2F3 BAK1 GADD45B PLCB4 BAD GADD45A GADD45G BAX CDKN1B CXCR4 CCND3 CCNE1 ABL1 PLD1 IL15 CCND2 HEY1 ESR2 VEGFC EP300 IL3 SKP2 CXCL12 SKP1 IL2RB RBX1 CCNE2 CTBP1 RASGRP2 DVL1 DVL2 DVL3 TCF7L2 CUL1 AXIN1 SMAD2;SMAD3 ZBTB17 TGFB2 SMAD4 TGFB3 CDK2 CCNA2-1 CCNA1 IL13RA1 DAPK1-1 RASSF1 MMP2 DAPK2 DAPK3 HDAC2 HDAC1 CDKN2B MSH6 BRCA2 RAD51 CCDC6 AR PIM1 PTGS2-2 PIM2 TCF7 ERBB2 APAF1 FASLG BBC3 CASP7 CASP8 BCL2L11 FADD BID BCL2L1 IL5RA CSF2RB JAK1 STAT5A STAT5B STAT1 LAMC1 RPS6KB1 RPS6KB2 RXRA CRKL MLH1 CRK TGFA CBL EGF MAPK10 ITGB1 EPAS1 LAMA5 PDGFA VHL FGF1 SHH FZD1 WNT5A BMP4 KEAP1 TGFBR2 BIRC2 NOTCH2 IL13 NOTCH1 PLCB1 TERT CREBBP VEGFA NFKB2 IL6ST NFE2L2 EPO EPOR KITLG IL3RA IL2RG JAK3 GSTO1 RALGDS F2R RET PDGFB FN1 GNG10 BDKRB2 BDKRB1 RAC3 APC2 F2 ARHGEF1 ROCK1 STAT4 ROCK2 IL12RB1 GNA13 GNA12 IGF1 IL7 TGFBR1-1 WNT2B FZD10 WNT5B WNT9B WNT9A WNT16 IL4R IFNGR1 WNT8A WNT8B RUNX1 WNT6 IFNG WNT11 IL23A WNT2 WNT3 WNT10B WNT10A FZD3 HIF1A FZD2 FZD5 FZD4 WNT3A WNT7B FZD7 FZD9 STAT6 VEGFB WNT7A FZD8 IL4 IL2RA RB1 GLI1 GLI3 GLI2 WNT SIGNALING%WIKIPATHWAYS_20260510%WP428%HOMO SAPIENS Wnt signaling FOSL1 NFATC2 CTBP1 NLK CTNNB1 DVL1 DVL2 DVL3 TCF7L2 PLCB1 RYK-1 AXIN1 ROR1 TPTEP2-CSNK1E;CSNK1E ROR2 JUN TCF7L1 PLCB2 PRKCG PRKCB PRKCA PPP3CC CTBP2 DKK1 SFRP1 WNT4 NFATC3 PLCB3 FRAT2 NFATC4 CAMK2B CCND1 CAMK2D TCF7 MYC CAMK2A ROCK2 CAMK2G SERPINF1 LEF1 LRP5 MAP3K7 LRP6 WNT1 SOX17 PLAU DKK4 CER1 CTNNBIP1 CSNK1A1 CSNK2A2 DKK2 SFRP2 FZD6 DAAM1 DAAM2 SFRP5 CSNK2B PORCN APC VANGL2 INVS CHD8 SOST KREMEN1 SENP2 PRICKLE2 PRICKLE1 CXXC4 NKD1 NKD2 WIF1 GPC4 NOTUM GSK3B WNT2B RAC1 FZD10 WNT5B VANGL1 PPP3CB WNT16 PPP3CA SFRP4 RHOA WNT6 WNT11 WNT2 WNT3 WNT10B PPP3R1 WNT10A FZD3 FZD2 FZD5 PLCB4 WNT3A WNT7B FZD7 FZD9 MAPK9 NFATC1 WNT7A FZD8 MAPK8 FZD1 CCND3 WNT5A CSNK2A1;CSNK2A3 CCND2 NICOTINE EFFECT ON DOPAMINERGIC NEURONS%WIKIPATHWAYS_20260510%WP1602%HOMO SAPIENS Nicotine effect on dopaminergic neurons GNB1 CHRNA3 DDC KCNK9 CHRNA5 CDK5 CHRNA4 TH CHRNA6 PPP1CA ADCY2 PPP1R1B SLC18A2 DRD4 KCNK3 GNAI1 PRKACA-1 GNG2 DRD2 DRD3 CHRNB2 TGF BETA RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP560%HOMO SAPIENS TGF beta receptor signaling EP300 TGFBR2 ZNF423 SERPINE1 CTNNB1 TGIF1-1 HRAS CREBBP JUN TFE3 NFKB1 SMAD2;SMAD3 SMAD4 JAK1 LEF1 FKBP1A WNT1 STAT1 TNF THBS1 STAT3 TGFBR3 TGFBR1-1 ZFYVE9 ITGB6 NOG FOXH1 RUNX3 ENG LTBP1 FOS SKIL LIF SMAD6 IFNG SMAD7 SKI BAMBI EGF SPP1 MAPK9 INHBA RUNX2 MAPK3 SMAD1 LEFTY2;LEFTY1 FST BMP4 ZEB2 TGFB1 SMAD9 SMAD5 REGULATION OF WNT B CATENIN SIGNALING BY SMALL MOLECULE COMPOUNDS%WIKIPATHWAYS_20260510%WP3664%HOMO SAPIENS Regulation of Wnt B catenin signaling by small molecule compounds LRP1 TNKS MBOAT1 DKK3 CTNNB1 LEF1 GSK3B FZD7 DVL2 TCF4 FZD8 WNT1 FZD1 AXIN1 CSNK1A1 SFRP4 APC MITOCHONDRIAL FATTY ACID OXIDATION DISORDERS%WIKIPATHWAYS_20260510%WP5123%HOMO SAPIENS Mitochondrial fatty acid oxidation disorders CPT2 SCP2 HADHB-1 ACADM SLC22A5 ACSL1 ACSL4 ACSL3 PECR ACADVL ECI1 ACSF2 HADHA ACADL SLC25A20 CPT1A HADH EHHADH-1 ACADS ARYLAMINE METABOLISM%WIKIPATHWAYS_20260510%WP694%HOMO SAPIENS Arylamine metabolism CYP1A2 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 STEROIDOGENIC PATHWAY%WIKIPATHWAYS_20260510%WP4463%HOMO SAPIENS Steroidogenic pathway CYP11A1 CYP19A1 HSD3B1;HSD3B2 STAR CYP17A1 HSD17B1 PLEURAL MESOTHELIOMA%WIKIPATHWAYS_20260510%WP5087%HOMO SAPIENS Pleural mesothelioma ITGAV SUZ12 EED CDKN2A SETD2 BRCA1 CDK4 EZH2 COL4A2 MAP3K1 CD44 MAPK1 PODXL RAF1 NFKB1 MAP2K6 RPS6KA5 PRKAB2 PRKAB1 MDK IGF2 ATG13 BDNF MAP3K10 ULK1 PRKAG1 PRKAG2 PRKAG3 WWTR1 RASSF5 ITPR3 RB1CC1 MAPKAPK2 YWHAB DKK1 SFRP1 WNT4 CD274 ITGA2 SELE CTNNA1 ATF2 MAP3K11 MEF2D MAP3K4 FLT3LG CDH11 RPS6KA1 NLRP3 ITGA3 IL6 ITGB2 ITGA6 GSK3B ELK1 AKT1 MAP3K5 CREB1 CDH2 CYCS-1 PRKAA2 MAPK9 MAPK8 MAP2K2;MAP2K1 CSNK2A1;CSNK2A3 MAPK7 MAPK3 NTF3 TGFB1 MAPK14 PTK2 FOSL1 TEAD4 SP1 BCL2 CTNNB1 DDIT3 CXCL5;CXCL6 JUN PIK3CA CXCL2;CXCL3;CXCL1-1 ITGB4 TRAF2 TCF7L1 ACTA2 RPS6KA3 EIF4G1 FOXM1 CSF2 CSF1 CTBP2 PGF MAX CDKN1A FLT1 FLT3 HGF FLT4 PTEN PIK3CD FRAT2 PIK3CB PIK3CG NDRG1 IGF1R RPTOR DEPTOR MAP4K1 CCND1 MYC AKT2 MST1 AKT3 CTNNA3 MLST8 KDR CTNNA2 VEGFD HRAS PDGFRB PDGFRA TSC2 COL4A1 TSC1 COL4A4 FOXO1-1 COL4A3 COL4A6 COL4A5 TTI1 AKT1S1 KIT ULK2 SOS1 LAMC3 LAMC2 MET TP53 TELO2 EPHA2 MMP3 CSF1R SRC LAMA2 MDM2-2 LAMA1 LAMA4 LEF1 LRP5 LAMA3 EGFR LAMB3 LRP6 LAMB2 WNT1 LAMB1 SOX17 NTRK1 NGFR PLAU NTRK2 CER1 CSNK1A1 CSNK2A2 INSR DKK2 FZD6 SFRP2 MTOR SFRP5 CSNK2B SLC2A1 PORCN APC RHEB CHD8 SOST GRB2 KREMEN1 TEK FGFR4 SENP2 FGFR3 CXXC4 FGFR2 SHC1-1 FGFR1 IL1B WIF1 NOTUM CDH1 PAK1 E2F1 BAK1 HCFC1 PLCB4 ATF3 IDO1 PDGFD CCL13;CCL2 PDGFC OGT-1 BAX PHC1 MOB1A;MOB1B PRSS23 TEAD1 CCL4L2;CCL4L1;CCL4 CCND3 TEAD2 CCL5 CCNE1 TEAD3 RING1 ATM CIT MMP14 IL10 PIGF ANGPT2 NTF4 CDH9 ITGA4 CDH8 ANGPT1 CDH7 CCND2 CDH6 YY1 CDH5 CXCL10 VEGFC CDH4 CDH3 MAP3K9 CXCL12 MAP3K6 HMGN1 LGALS9C;LGALS9;LGALS9B TNIK DSC3 CTBP1 SAV1 BAG2 MAD1L1 MDM4 DVL1 NF2 DVL2 MCU DVL3 ACTC1;ACTG2 ADAMTS1 TCF7L2 UHRF1 CUL1 EIF4B RYK-1 CTHRC1 AXIN1 ANGPT4 ROR1 SPARC TPTEP2-CSNK1E;CSNK1E RASSF2 ROR2 RASSF3 RASSF4 RASSF6 BTRC STK38L LIMD1 BMI1 GABPA MAP4K2 MINK1 TNNT1 CD47 VGLL4 MAP4K3 MAP4K4 IL34 MAD2L1 WWC1 CDK7 EFNA5 EFNA4 CDK2 STK3 CDH20 FABP4 CDH22 CDH24 EFNA1 EFNA3 LIN28B EFNA2 CASP1 LATS1 ACTA1 LATS2 CDH10 KIF23 CDH12 CDH13 CDH15 CDH16 RASSF1 CDH18 MMP2 CDH19 SLC3A2 MKNK1 MKNK2 MMP9 BECN1 HMGB1-1 BARD1 TCF7 INS;INS-IGF2 MCL1 BBC3 JAK1 STAT1 RPS6 LAMC1 CDH17 RPS6KB1 DKK4 RPS6KB2 BUB1B-PAK6;PAK6 AREG MAP2K4 BTC HBEGF TGFA EIF4EBP1 MAP2K7 CCN2 NGF PAK3 PAK2 PAK5 PAK4 EGF MAPK10 ITGB1 LAMA5 PDGFA FGF1 FZD1 WNT5A AJUBA PRKAA1 TERT VEGFA KITLG PPARGC1A MAP2K3 AMOT YAP1-1 MAP2K5 PDK1 SETD5 KMT2C SETDB1 FGF2 FGF3 ACTG1 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 PDGFB FGF20 FGF23 FGF22 FGF21 FN1 RASSF7 WDR5 KDM6A ASXL1 FGF17 BAP1 FGF14 FGF19 ACTB-1 FGF18 FGF13 FGF12 FGF11 FGF10 ITGA1 AGER SERPINF1 RNF2 SLC7A5 IGF1 MAP3K2 CSF3 MAP3K3 WNT2B FZD10 WNT5B WNT16 SFRP4 WNT6 WNT11 WNT2 WNT3 WNT10B WNT10A FZD3 HIF1A FZD2 FZD5 WNT3A WNT7B FZD7 FZD9 VEGFB WNT7A FZD8 ITGB3 RBBP4 OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20260510%WP623%HOMO SAPIENS Oxidative phosphorylation NDUFA10 NDUFB9 NDUFA11 GZMH;GZMB-1 ATP6AP1 ATP6AP2 NDUFC1 NDUFS8 NDUFS7 NDUFS6 NDUFS4 NDUFS3 NDUFS2 NDUFS1 NDUFB8 NDUFB7 NDUFB10 NDUFB6 NDUFB5 NDUFB4 NDUFB2 ATP5MC2 NDUFA4 NDUFA4L2 ATP5MC3 NDUFB1 ATP5MC1 ATP5F1A ATP5F1B NDUFC2;NDUFC2-KCTD14 NDUFV3 NDUFV2 NDUFV1 ATP5MG ATP5ME NDUFA9 DMAC2L NDUFA8 ATP5PF NDUFA7 ATP5PD NDUFA6 NDUFA5 ATP5PB NDUFA3 ATP5F1D NDUFAB1 ATP5PO NDUFS5-1 WNT BETA CATENIN SIGNALING INHIBITORS IN CURRENT AND PAST CLINICAL TRIALS%WIKIPATHWAYS_20260510%WP5442%HOMO SAPIENS Wnt Beta catenin signaling inhibitors in current and past clinical trials LRP6 CREBBP CTNNB1 LRP5 PORCN METAPATHWAY BIOTRANSFORMATION PHASE I AND II%WIKIPATHWAYS_20260510%WP702%HOMO SAPIENS Metapathway biotransformation Phase I and II CYP1A1 CYP2E1 CYP27B1 CYP24A1 CYP11B1;CYP11B2 CYP46A1 AKR1B1 AKR1D1 BAAT CYP7B1 CYP27A1 CYP51A1 GSTO1 MGST1 CYP1B1 UGT1A1;UGT1A6 GSTM4 GSTA3;GSTA5;GSTA1;GSTA2 GSTM3 TPMT HS6ST1 GSTO2 HS6ST2 NAA80 GSTP1 HS6ST3 NDST2 COMT AKR7A2 AKR7A3 NDST4 NDST3 GSTK1 SULT2B1 CYP39A1 CYP2U1 SULT6B1 NNMT HS3ST3A1 GSTCD GLYAT GPX4 CYP4F22 CYP2C9;CYP2C19 CYP2B6 CYP1A2 CYP4X1 CHST11 MGST3 CHST12 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 MGST2 CHST10 CHST13 CHST14 EPHX1 CYP26A1 CYP27C1 CYP2S1 NAT9 GAL3ST1 NAT10 NAT14 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 HS2ST1 SULT1C3 GSTA4 CYP19A1 SULT1C2 CYP26B1 AKR1B15;AKR1B10 CYP4V2 CYP2R1 UGT2A1 GSS GAL3ST3 GSR SULT4A1 GSTT2B;GSTT2 GAL3ST4 CHST8 GSTM1;GSTM2-1 GSTA3;GSTA1 HS3ST3B1 CHST9 NAA30 CHST7 GPX5 AKR1A1 KCNAB1 KCNAB2 KCNAB3 INMT NAA40-2 CHST4 NAT8L CHST2 HNMT CHST3 CYP2J2-1 NAA20 CYP2C18-1 NAA50-1 CYP2F1 NAT8-2 CYP4B1 FMO1 HS3ST5 FMO2 HS3ST6 FMO3 FMO4 HS3ST4 FMO5 NDST1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 HS3ST1 HS3ST2 SULT1B1-1 GSTZ1 CYP2W1 CHST6 CYP8B1 CYP20A1 CYP7A1 CHST1 CYP17A1 CYP21A2 SULT2A1-4 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 CYP11A1 EPHX2 CYP2D6;LOC107987479;LOC107987478-1 CYP2A13;CYP2A6;CYP2A7-1 GPCRS CLASS C METABOTROPIC GLUTAMATE PHEROMONE%WIKIPATHWAYS_20260510%WP501%HOMO SAPIENS GPCRs class C metabotropic glutamate pheromone GABBR2 GABBR1 CASR GRM2 GPRC5B GPRC5A GRM1 GRM4 GRM7 GRM5 GRM6 GRM8 GPRC5D GPRC5C GRM3 NEURAL CREST CELL MIGRATION IN CANCER%WIKIPATHWAYS_20260510%WP4565%HOMO SAPIENS Neural crest cell migration in cancer MMP9 PIK3CD PIK3CB PIK3CG BUB1B-PAK6;PAK6 AKT2 AKT3 PIK3R4 RAC1 PIK3R6 AKT1 JUN PIK3R5 PIK3CA PIK3R3 FOS RHOA PAK1 PAK3 PAK2 PAK5 PAK4 TRIO EPHB6 ARF1 EPHB2 BDNF EPHB1 EPHB4 EPHB3 MMP8 TIAM1 SORT1 CDH11 F2RL2 NGEF NGFR NTRK2 STAT3 KIDINS220 MMP2 PATHOGENIC ESCHERICHIA COLI INFECTION%WIKIPATHWAYS_20260510%WP2272%HOMO SAPIENS Pathogenic Escherichia coli infection YWHAZ ARPC1B FYN CTNNB1 CLDN1 ACTG1 TUBAL3 NCK2 ARPC1A NCK1 ARPC5L LY96 WASL TUBA1C CDH1 TUBA1A ROCK1 TUBB1 ROCK2 OCLN-1 WAS TUBA3E;TUBA3C-1 TUBB2B;TUBB2A ARPC4 CDC42 TUBB4B TUBA4A CTTN NCL-1 KRT18 ARPC2 ARPC3 EZR RHOA TUBB4A;TUBB;TUBB8B;TUBB8 HCLS1 ARHGEF2 TLR5 TUBB3;TUBB6 TUBA8 TLR4 CD14 ITGB1 ARPC5 ABL1 PRKCA ACTB-1 YWHAQ CANONICAL AND NON CANONICAL NOTCH SIGNALING%WIKIPATHWAYS_20260510%WP3845%HOMO SAPIENS Canonical and non canonical Notch signaling MAML1 NOTCH2 NOTCH1 JAG2 DLL1 DLL3 DLL4 JAG1 RRAS CHUK HES1 ADAM10 PSEN2 MAML2 PSEN1 RBPJ DNER CNTN6 DLK1 DLK2 LEF1 MFAP1 MFAP2 MAML3 NOTCH3 NOTCH4 HEY1 RIBOFLAVIN AND COQ DISORDERS%WIKIPATHWAYS_20260510%WP5037%HOMO SAPIENS Riboflavin and CoQ disorders ETFDH ETFA COQ9 COQ7 APTX SLC52A1;SLC52A2 COQ6 COQ2 PDSS2 PDSS1 COQ8A FLAD1 RFK DNA DAMAGE RESPONSE ONLY ATM DEPENDENT %WIKIPATHWAYS_20260510%WP710%HOMO SAPIENS DNA damage response only ATM dependent FOSL1 BCL2 CDKN2A CTNNB1 DVL1 DVL2 DVL3 TCF7L2 AXIN1 JUN MAP3K1 NFKB2 PIK3CA PCK2 MAPK1 G6PC1 TCF7L1 NFKB1 SMAD2;SMAD3 SMAD4 PDK1 RBL2 CAT HMGB1-1 WNT4 CDKN1A PTEN PIK3CD RAC3 PIK3CB PIK3CG LDLR CCND1 TCF7 MYC AKT2 AKT3 IRS1 PIK3C3 PIK3R4 PMAIP1 PIK3C2G PIK3C2A HRAS PIK3C2B PIK3R5 CDC42 ERBB2 FASLG BBC3 SOS1 BCL2L11 SOS2 TP53 MAP3K4 FOXO3 MDM2-2 LEF1 MAP3K7 WNT1 PLAU INSR APC KRAS BCL6 GRB2 SCP2 SHC1-1 GSK3B WNT2B RAC1 AKT1 WNT5B WNT16 PIK3R3 PIK3R2 RHOA PIK3R1 WNT6 WNT11 NRAS WNT2 WNT3 WNT10B WNT10A BAK1 MAPK10 BAD WNT3A WNT7B MAPK9 BAX CDKN1B WNT7A MAPK8 CCND3 WNT5A ABL1 ATM TGFB1 MLKL TP73 PPP2R5E CCND2 PPP2R5C BIK CCNG2 MIR TARGETED GENES IN LEUKOCYTES%WIKIPATHWAYS_20260510%WP2003%HOMO SAPIENS miR targeted genes in leukocytes ACAA2 SERPINE2 PLXND1 TUSC2 PRPF40A C1orf56 ARID4B ARF4-1 DCAF7 TXN2 ARHGDIA CHORDC1 BCL2 CDK5RAP1 CTNNB1 CDK5RAP3 ANAPC1 VPS39 IFRD1 GOLGA7-1 PISD CDK6 RAB34 WDFY1 PPIF MATR3 DDX5 RAB5C SLC1A4 ADIPOR2 MAP3K8 RTN4 CORO1C MRPL20 SRSF10 RAB6A SAC3D1 MPDU1 ATP6V1F ATP6V0A1 SNX6 CD164 PHC2 TBCA TNFSF9 SFXN1 SLC25A1 TRAM1 IGF2R ADPGK TNFAIP2 ADAR LMNB2 PRSS21 MRC2 RDH10 TMEM43 CSRP1 TMED3 TMEM109 SH3BGRL3 ACP2 NELFCD CTSC SCYL1 GAK SLC7A6 CDCP1 THBS1 POM121;POM121C DNAJB1 RFT1 FRG1 PTRH1 SLC7A11 PNP-1 BRPF3-1 HMOX1 UNC93B1 CAPG PTPA SHOC2 CDIPT CA12 TXNRD1 SEC24A AP3D1 ARCN1 WDR11 FMNL2 ATP6V0E2;ATP6V0E1 GYS1 SNAP23 USP1 TYMS ATP2A2 TPM3 YWHAQ LPL FADS1 POLE4 IDH1 GNA13 GNAI2 ANXA2 MCL1 ANPEP LAMTOR3 PPIB BCL6 PKM G6PD PDLIM5 SPTLC1 POLR2C CAP1 TUBA1A TMED10 KCNN4 CEBPB HNRNPM MTHFD2 RHOG ZEB1 MAPK14 REGULATORY CIRCUITS OF STAT3 SIGNALING%WIKIPATHWAYS_20260510%WP4538%HOMO SAPIENS Regulatory circuits of STAT3 signaling IL2RB RPTOR DEPTOR MLST8 JAK2 MAPKAP1 IL6R RICTOR CREBBP PDGFRB F2RL3 PDGFRA IFNAR2 IL6ST MAPK1 CSF2RA MAPK6 AKT1S1 MAPK4 MAPK12 IFNAR1 IL12RB2 MAPK11 IFNGR2 IL7R PTPRC IL3RA IL5RA CSF2RB SRC JAK1 IL2RG EGFR JAK3 AGTR1 IL9R AGTR2 F2RL2 PRKCB SETD7 STAT3 MTOR PTPRT CNTFR MPL GHR DUSP2 IL11RA TRIM28 OSMR IL20RA STMN1 IL20RB CTF1 IL10RB LIFR IL10RA PIAS3 IFNLR1 MAPK15 IL27RA F2R IL22RA1 PTPRD IFNGR1 TYK2 MAPK10 SOCS3 IL21R MAPK9 MAPK8 CSF3R MAPK13 IL2RA MAPK7 MAPK3 MAPK14 CATALYTIC CYCLE OF MAMMALIAN FLAVIN CONTAINING MONOOXYGENASES FMOS %WIKIPATHWAYS_20260510%WP688%HOMO SAPIENS Catalytic cycle of mammalian flavin containing monooxygenases FMOs FMO1 FMO2 FMO3 FMO4 FMO5 PATHWAYS AFFECTED IN ADENOID CYSTIC CARCINOMA%WIKIPATHWAYS_20260510%WP3651%HOMO SAPIENS Pathways affected in adenoid cystic carcinoma CHEK1 EP300 PTEN ARID4B CEBPA SMARCE1 MYBL1 CTBP1 SETD2 MYC ARID1A BRCA1 NOTCH1 UHRF1 PRKDC HRAS CREBBP PIK3CA NCOR1 ERBB2 RAF1 MYB TP53 FOXO3 SMC1A KMT2C NSD1 BCOR FGFR4 AKT1 JMJD1C TLK1 CMTR2 MAGI1 KDM6B BRD1 FBXW7 MAGI2 ATRX INSRR ARID5B IL17RD MORF4L1-2 FOXP2 CNTN6 MYCN KAT6A BCORL1 SRCAP MAML3 DTX4 MGA MYCBP-1 KDM6A ERBIN SMARCA2 MAP2K2;MAP2K1 H2AC16;H2AC11 H1-4 KANSL1 NFIB FGF16 ATM MAX CHEK2 ANGIOPOIETIN LIKE PROTEIN 8 REGULATORY PATHWAY%WIKIPATHWAYS_20260510%WP3915%HOMO SAPIENS Angiopoietin like protein 8 regulatory pathway THRB MAP3K9 MAP3K6 PRKAA1 MAPKAP1 RICTOR EIF4E MAP3K1 PIK3CA MAP3K8 MAPK1 G6PC1 RAF1 MAP3K14 MAP4K2 MAP2K6 MINK1 RPS6KA5 PRKAB2 PRKAB1 MAP4K3 MAP4K4 MAP2K3 MAP2K5 MAP3K10 PRKAG1 SESN3 PRKAG2 PRKAG3 RPS6KA3 SREBF2 SREBF1 GYS1 ABCG8 ABCG5 ANGPTL8 MAPK13 IRS4 CBLC RPS6KA4 MAP3K13 MAP3K12 FLOT1 FLOT2 FBP1 RHOQ MAP4K5 PTPN1 LPL TRIP10 CYP2B6 PIK3CD PIK3CB CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PIK3CG RPTOR MAP4K1 RAPGEF1 AKT2 IRS2 MLST8 IRS1 PIK3C3 PIK3R4 SCD FASN PIK3C2G PIK3C2A HRAS MAP3K11 TSC2 TSC1 INS;INS-IGF2 FOXO1-1 MAPK6 MAPK4 MAPK12 MAPK11 PCK1 SOS1 SOS2 GSK3A MAP3K4 FOXO3 MAP3K7 RPS6KB1 RPS6KB2 RPS6KA1 INSR MTOR NR1H3 SLC2A1 RHEB CYP7A1 RXRA SLCO1C1 SLC2A4 SHC1-1 CBLB GSK3B SLC16A2 MAP2K4 MAP3K2 PDPK1 MAP3K3 CAP1 AKT1 EXOC7 MAP3K5 CRK SHC3 SHC2 PIK3R3 CBL PIK3R2 PIK3R1 EIF4EBP1 MAP2K7 PRKAA2 MAPK10 RPS6KA6 RPS6KA2 MAPK9 MAPK8 MAP2K2;MAP2K1 MAPK7 MAPK3 THRA MAPK14 CILIARY LANDSCAPE%WIKIPATHWAYS_20260510%WP4352%HOMO SAPIENS Ciliary landscape H3-3A DVL3 NFKB1 MAEA ARMC8 VIM MCM7 COPS7A MCM3 COPS4 MCM4 COPS3 MCM5 COPS6 MCM6 IFT22 MCM2 COPS5 HDAC2 COPS2 HDAC1 COPS8 WEE1 RAB8A COX6C NDUFA9 WDR26 RMND5A NDUFA5 RANBP9 CALM1 MKLN1 GID4 CAMK2A MCM8 MCM9 EFTUD2 HTRA2 CD2BP2 MFAP1 TFAP2A DCAF7 ARHGDIA CTNNB1 GDI1 CREBBP DDX5 SNRPB2 DYNC2I2 DYNC2I1 AGPAT2 TRAF3IP1 IFT172 RNGTT CEP97 TFAP2E;TFAP2B IFT80 LZTFL1 IFT88 YAP1-1 IFT81 TTC30A;TTC30B POM121;POM121C BBS2 BBS1 IFT122 FUZ IFT20 MKS1 IFT27 TTC26 HSPB11 IFT52 BBS9 BBS7 IFT57 BBS5 BBS4 DYNLT1 IFT140 IQGAP1 IFT43 IFT46 DYNLT2B CTBP2 IFT74 TTC8 CLUAP1 SMC4 MSH2 PSMD8 PSMD7 DYNC1LI1 AFG3L2 MYL6 INTU COPS7B IQGAP2 IQGAP3 NUP88 CDR2 AAR2 ACSL3 CTSA EXOC6B BBIP1 AIMP1 EHD3 WNK1 RANBP10 MYL6B NEFL TNKS1BP1 NEFM TMED1 ZYG11B NUDC CNOT6L EXOC8 EIPR1 RAB3IL1 NME8 EXOC4 EXOC3 EXOC6 EXOC5 MAPRE2 EXOC2 PAFAH1B1 EXOC1 RALB DYNC1I2 ECHS1 SSNA1 EXOSC7 EXOSC4 PGRMC2 EXOSC9 EXOSC2 DYNC1H1 WHRN UBE2D3;UBE2D2 LRPPRC TIPRL-2 PSMC6 PSMC4 GID8 YPEL5 DGKE APMAP CBS;CBSL RAB2A ERF APC ANKS6 ARL8B PSMD12 PSMD13 SPATA7 CDH23 NEK8 TFAP2C UBE2H TBC1D4 TFAP2D RHBDD2 UQCC1 NEK7 CNOT10 LSM4 CNOT1 LCN2 DYNLRB2 DYNLRB1 CNOT9 RAC1 DOCK5 ZMYND19 EXOC7 MCM10 RPGR CEP290 SNAP29 IQCB1 EIF5B RBM14 NUP133 ARFGAP3 RABEP2 EFHC2 CCDC40 VPS4A USH1C EHBP1 RAB21 RMND5B DNPEP STOM DCAF11 LCA5 RAB14 GLB1 VAPB XPNPEP3 GLA RB1 OPIOID RECEPTOR PATHWAYS%WIKIPATHWAYS_20260510%WP5093%HOMO SAPIENS Opioid receptor pathways PIK3CG SPINAL CORD INJURY%WIKIPATHWAYS_20260510%WP2431%HOMO SAPIENS Spinal cord injury IL2 GFAP CXCL10 ZFP36 SELP ARG1 GDNF PTPRA CSPG4 NR4A1 BTG2 NCAN TNFSF13B TACR1 RGMA ROS1 MMP12 VCAN GAP43 LTB NTN1 AIF1 PTPRZ1 SLIT1 CDK4 SLIT3 SLIT2 CCNG1 CCR2 RTN4 CXCL2;CXCL3;CXCL1-1 MAPK1 NOS2 CD47 MBP NOX4 GJA1 CDK2 BDNF CDK1 VIM ANXA1 PRKCA MMP9 NOS1 E2F5 APEX1 LGALS3 IL1R1 IL1A ICAM1 CHST11 PTGS2-2 CCND1 MYC EGR1 ROCK2 COL4A1 CDC42 LEP TP53 FOXO3 FKBP1A EGFR NGFR TNF GRIN1 LTB4R C5 IL6 PLA2G6 IL1B CXCL8 RAC1 CASP3 RHOC RHOB C1QB PPP3CA FOS RHOA SOX9 IFNG TLR4 E2F1 COL2A1 GADD45A ACAN CCL13;CCL2 XYLT1 AQP4 CDKN1B PLA2G2A-1 AQP1 IL4 EPHA4 SEMA6A OMG RB1 MIF MAPK3 PDYN BCAN TGFB1 MAG RTN4R PLA2G5 KLK8 EFNB2 PLXNA2 LOC102725035;LOC107987425;LILRB3;LOC112268337;LOC107987441;LOC112268340;LOC112268336;LOC112268334;LOC107987462;LILRB5 1P36 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP5345%HOMO SAPIENS 1p36 copy number variation syndrome RBX1 DVL1 CUL3 TRIM25 INTS11 PANK4 VEGFA INTS13 ELAVL1 ESR1 INTS14 INTS10 DLST GDE1 CDK11A;CDK11B TRAF2 MRPL20 TMEM52 GRIK2 TRAF5 IFIT1 NOC2L SMAD2;SMAD3 OR4F21;OR4F16;OR4F29;OR4F3 METTL14 SDF4 SMAD4 CCNL2 PLEKHN1 TNFRSF4 SAMD11 CD160 MUSK TNFRSF18 KRT17 OR4F5;OR4F17;OR4F4 SSU72 PEX2 ACAP3 SCNN1D RER1 HES5 CPTP MMP23B C1QTNF12 PEX5 MXRA8 VWA1 AURKAIP1 PERM1 KLHL17 MEPCE LRP4 UBE2J2 ATAD3A;ATAD3B PHKG2 VTN BTLA PUSL1 MCM2 TAS1R3 GABRD NADK HES4 IFIH1 TNFSF18 HSPA8 CFAP74 MIB2 PEX10 ISG15 B3GALT6 PEX12 RNF223 CALML6 MORN1 TNFSF4 FNDC10 ANKRD65 INTS4 PLCH2 PRKCZ INTS9 DLL1 AGRN SLC35E2B C1orf159 COMMD1 SKI TNFRSF14 DKK3 PARD6B GNB1 ARF6 TGFB1 MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY%WIKIPATHWAYS_20260510%WP1544%HOMO SAPIENS MicroRNAs in cardiomyocyte hypertrophy PIK3CD TAB1 PIK3CB NFATC4 PIK3CG IGF1R CAMK2D CTNNB1 DVL1 AKT2 EIF2B5 IKBKB EDN1 ROCK1 ROCK2 CHUK PIK3CA IL6ST MAPK1 IKBKG RAF1 MAP3K14 MAPK4 NFKB1 HDAC7 MAP2K6 NPPB NPPA MAP2K3 CDK7 MAP2K5 LRP5 CDK9 LRP6 PLCB2 TNF PRKCB STAT3 MTOR AGT IKBKE FGFR2 GATA4 FGF2 IGF1 MYLK GSK3B MAP2K4 PDPK1 RAC1 NRG1 MYLK3 AKT1 MYEF2 CISH CTF1 HDAC9 PPP3CB RCAN1 PPP3CA PIK3R3 RHOA PIK3R2 LIF PIK3R1 MAP2K7 EGF FZD2 HDAC4 WNT3A CALM1 PLA2G2A-1 MAPK8 MAP2K2;MAP2K1 FZD1 WNT5A PRKG1 HDAC5 MAPK7 MAPK3 TGFB1 MAPK14 FATTY ACID TRANSPORTERS%WIKIPATHWAYS_20260510%WP5061%HOMO SAPIENS Fatty acid transporters FABP1 SLC27A4 ACSL1 ACSL6 ACSL5 FABP3 FABP4 ACSL4 ACSL3 FABP2 CD36 FABP9 FABP5 FABP7 FABP6 ACSBG1 ACSBG2 SENESCENCE AND AUTOPHAGY IN CANCER%WIKIPATHWAYS_20260510%WP615%HOMO SAPIENS Senescence and autophagy in cancer IL3 CXCL14 CDC25B CCL3L1;CCL3L3;CCL3;CCL18 BCL2 CDKN2A SPARC JUN IRF1 CD44 IL6ST CXCL2;CXCL3;CXCL1-1 MAPK1 RAF1 BMI1 SMAD2;SMAD3 SMAD4 IFNB1-4 MAP2K3 ATG13 ULK1 KMT2A MAP1LC3B2;MAP1LC3B-1 GABARAPL2 THBS1 PCNA GABARAP IRF7 RB1CC1 MAP1LC3C BECN1 LAMP1 LAMP2 SLC39A2 SLC39A1 SLC39A4 SLC39A3 SH3GLB1 SERPINB2 IGFBP5 IL1A FKBP8 IGFBP7 UVRAG TNFSF15 IL24 ING1 ING2 FN1 IRF5 RNASEL AMBRA1 IFI16 CREG1 RSL1D1 BMP2 CDKN1A PTEN IGF1R SERPINE1 MLST8 PIK3C3 ATG7 IL6R HRAS IGFBP3 INS;INS-IGF2 AKT1S1 GSN TP53 SRC MDM2-2 PLAU MTOR VTN IL6 IGF1 IL1B GSK3B SQSTM1 CXCL8 MAP1LC3A ATG5 ATG3 PLAT ATG10 ATG14 ATG12-1 ATG16L1 COL10A1 IFNG E2F1 CEBPB COL1A1 CDKN1B COL3A1 MAP2K2;MAP2K1 INHBA RB1 TGFB1 MMP14 BRAF MAPK14 DISORDERS IN KETOLYSIS%WIKIPATHWAYS_20260510%WP5195%HOMO SAPIENS Disorders in ketolysis ACAT2 ACAT1 BDH1 OXCT1-1 HMGCS1-1 AMINO ACID METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260510%WP5213%HOMO SAPIENS Amino acid metabolism in triple negative breast cancer cells PSPH SLC1A5 GLS SLC2A1 PSAT1 PHGDH SLC7A11 OXYSTEROLS DERIVED FROM CHOLESTEROL%WIKIPATHWAYS_20260510%WP4545%HOMO SAPIENS Oxysterols derived from cholesterol CH25H CYP8B1 GPR183 NR1I2 CYP7A1 IL17D ACOT6 IL17C CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ACOT4 SCP2 NR1H2 RORC ACOT2;ACOT1 ESR1 CYP46A1 SLC27A2 SULT2A1-4 EBP HSD11B1 AKR1D1 HSD11B2 IL17B DHCR7 HSD3B7 IL25 INSIG1 BAAT IL17F DBP THEM5 CYP7B1 LBP CYP27A1 SULT2B1 IL17A ACOT9 CYP39A1 AMACR ACOT8 EPHX2 ACOX2 ACOT7 ACOT11 SLC27A5 ACOT12 ACOT13 ESR2 SYNAPTIC SIGNALING ASSOCIATED WITH AUTISM SPECTRUM DISORDER%WIKIPATHWAYS_20260510%WP4539%HOMO SAPIENS Synaptic signaling associated with autism spectrum disorder PTEN PIK3CD PIK3CB GRIN2C GRIN3B RPTOR CAMK2B GRIN3A UBE3A AKT2 AKT3 PRKAA1 HRAS TSC2 TSC1 PIK3CA MAPK1 PRKAB2 PRKAB1 ARC GRM1 GRIN2D BDNF SYNGAP1 CAMK4 PRKAG1 PRKAG2 HOMER1 RPS6KB1 PRKAG3 GRIN2B NTRK2 GRIN1 DLG4 SHANK3 MTOR RHEB KRAS GSK3B CACNA1C AKT1 PIK3R3 PIK3R2 PIK3R1 EIF4EBP1 GRIN2A NRAS PRKAA2 NF1 MAPK3 WARBURG EFFECT MODULATED BY DEUBIQUITINATING ENZYMES AND THEIR SUBSTRATES%WIKIPATHWAYS_20260510%WP5216%HOMO SAPIENS Warburg effect modulated by deubiquitinating enzymes and their substrates LDHA PGK1 HIF1A OTUB2 USP7 USP37 USP44 MYC OTUD7B VHL USP28 HK2 OTUD6B KDR AKT1 VEGFA U2AF2 PIK3CA FOXO1-1 PGAM1 G6PC1 MTOR SLC2A1 FBP1 MALATE ASPARTATE SHUTTLE%WIKIPATHWAYS_20260510%WP4315%HOMO SAPIENS Malate aspartate shuttle SLC1A3 SLC25A11 MDH1 GOT2-1 DEREGULATION OF RAB AND RAB EFFECTOR GENES IN BLADDER CANCER%WIKIPATHWAYS_20260510%WP2291%HOMO SAPIENS Deregulation of Rab and Rab effector genes in bladder cancer MLPH RPH3A RAB27A RPH3AL SYTL1 RAB27B GCC2 MYRIP SYTL5 SYTL4 UNC13D SYTL3 SYTL2 MADD TBC1D10A EXPH5 CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260510%WP197%HOMO SAPIENS Cholesterol biosynthesis pathway LSS IDI1 CYP51A1 FDPS MVK SC5D DHCR7 MSMO1 PMVK NSDHL MVD SQLE FDFT1 HMGCR HMGCS1-1 MEVALONATE PATHWAY%WIKIPATHWAYS_20260510%WP3963%HOMO SAPIENS Mevalonate pathway ACAT2 PMVK MVD FDPS HMGCR MVK HMGCS1-1 CHOLESTEROL METABOLISM WITH BLOCH AND KANDUTSCH RUSSELL PATHWAYS%WIKIPATHWAYS_20260510%WP4718%HOMO SAPIENS Cholesterol metabolism with Bloch and Kandutsch Russell pathways CH25H ELOVL5 ACSL1 NR1H2 ELOVL2 CYP51A1 ELOVL3 ACSL4 ACSL3 FADS2 MSMO1 SCD SREBF1 FASN TM7SF2 FADS1 NSDHL ACOT2;ACOT1 LBR MYLIP CYP46A1 HMGCS1-1 ELOVL4 LSS SOAT1 ABCG1 HSD17B7 EBP ABCA1 IDI1 FDPS MVK SC5D SOAT2 GGPS1 DHCR7 ACAT2 PMVK DHCR24 MVD FDFT1 SQLE HMGCS2 SREBF2 CYP27A1 HMGCR NR1H3 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260510%WP4249%HOMO SAPIENS Hedgehog signaling HHIP CCND1 BCL2 GRK2 PTCH1 KIF7 CUL3 SMO CSNK1D TPTEP2-CSNK1E;CSNK1E SPOP CSNK1G1 PRKACB-1 PTCH2 LRP2 BOC CDON CSNK1G3 EVC SMURF2 SMURF1 FBXL17 GPR161 SPOPL GAS1 CSNK1G2 DHH SHH GRK3 EVC2 ARRB1 CSNK1A1 ARRB2 KIF3A GLI1 GLI3 PRKACA-1 IHH GLI2 CCND2 MIR TARGETED GENES IN ADIPOCYTES%WIKIPATHWAYS_20260510%WP2001%HOMO SAPIENS miR targeted genes in adipocytes LPL PHC2 TGFBR2 CEBPB ELOVL5 IGF2R HIPK3 PICALM TMEM43 CSRP1 CAP1 FADS1 SRSF9 TMED10 SRSF10 CYP1B1 ADIPOGENESIS%WIKIPATHWAYS_20260510%WP236%HOMO SAPIENS Adipogenesis RXRG NR2F1 SP1 CTNNB1 DVL1 DDIT3 E2F4-1 HNF1A GATA2 IL6ST PCK2 FRZB AGPAT2 BSCL2 LPIN2 SMAD2;SMAD3 LPIN3 PPARGC1A STAT2 PTGIS RBL2 RBL1 MEF2A WWTR1 CNTFR SREBF1 NRIP1 NCOR2 KLF6 NCOA1 SOCS1 IRS4 EBF1 BMP2 CDKN1A LPL CEBPA CEBPD CYP26A1 SERPINE1 EGR2 KLF15 MEF2C IRS2 MEF2B;BORCS8-MEF2B KLF5 IRS1 LPIN1 SCD CYP26B1 INS;INS-IGF2 FOXO1-1 NCOR1 PPARG ADIPOQ RARA MEF2D LEP PCK1 PPARD BMP1 STAT5A CISD1 RETN MBNL1 STAT5B GTF3A PRLR WNT1 STAT1 TRIB3 ZMPSTE24 NDN TNF BMP3 CFD ID3 PLIN2 ASIP SPOCK1 GDF10 STAT3 OSM NR1H3 KLF7 PNPLA3 MIXL1 AGT IL6 RXRA GATA4 SLC2A4 PPARA IGF1 LMNA NAMPT RORA AHR WNT5B LIFR NCOA2 SFRP4 LIF CREB1 WNT10B E2F1 GATA3 HIF1A CEBPB EPAS1 GADD45B SOCS3 DLK1 GADD45A LIPE STAT6 NR3C1 FZD1 FOXC2 FAS RB1 MIF CELF1 BMP4 TGFB1 PLIN1 UCP1 BILE ACID SYNTHESIS AND ENTEROHEPATIC CIRCULATION %WIKIPATHWAYS_20260510%WP4389%HOMO SAPIENS Bile acid synthesis and enterohepatic circulation CYP7A1 SLC10A1 SLC10A2 FGFR4 LDLR MAPK3 FGF19 MAPK1 ABCG8 ABCB11 ABCG5 FXR1-1 EPAC1 AND PKA REDUCTION OF RETINAL INFLAMMATION%WIKIPATHWAYS_20260510%WP5440%HOMO SAPIENS EPAC1 and PKA reduction of retinal inflammation PRKAR1B PRKAR1A NLRP3 RAPGEF3 PRKAR2A IL1B PRKACB-1 NEK7 OMEGA 3 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260510%WP5432%HOMO SAPIENS Omega 3 fatty acids in senescence GPR32 DPEP1 CYP2C9;CYP2C19 CYP2E1 CYP1A2 ALOX15 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ALOX12 ELOVL5 PTGS2-2 PTGS1 ELOVL2 FADS2 TBXAS1 FADS1 GGT1 GSTM4 GSTP1 PTGIS HPGD FPR2 LTC4S PLA2G4A LTA4H ALOX5 PTGES PTGDS CYP2D6;LOC107987479;LOC107987478-1 EPHX2 ALOX15B CORI CYCLE%WIKIPATHWAYS_20260510%WP1946%HOMO SAPIENS Cori cycle HK1 LDHA GAPDH-1 PFKP PGK1 ALDOA SLC2A4 G6PD SLC2A2 INS;INS-IGF2 GPI PGAM1 TPI1 TALDO1 SLC2A1 GPT NANOPARTICLE TRIGGERED AUTOPHAGIC CELL DEATH%WIKIPATHWAYS_20260510%WP2509%HOMO SAPIENS Nanoparticle triggered autophagic cell death ATG9B ULK2 VMP1 CHAF1A SH3GLB1 UVRAG BCL2 MAP1LC3A ULK1 AMBRA1 ATG5 ATG3 ATG7 ATG10 INSR TSC2 ATG14 TSC1 INS;INS-IGF2 BECN1 ATG12-1 ATG16L1 ATG4A ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20260510%WP554%HOMO SAPIENS ACE inhibitor pathway ACE2 BDKRB2 ATP6AP2 BDKRB1 MAS1 REN CYP11B1;CYP11B2 CTSG CMA1 AGTR1 AGTR2 TGFB1 ACE NOS3 KNG1 NR3C2 AGT INFLUENCE OF LAMINOPATHIES ON WNT SIGNALING%WIKIPATHWAYS_20260510%WP4844%HOMO SAPIENS Influence of laminopathies on Wnt signaling CEBPA TOR1AIP1 CEBPD FNTA EMD SLC2A4 ICMT TLE1 CCND1 HMGA2 TCF7 AGO2 CTNNB1 GSK3B DICER1 TARBP2 TCF7L2 CDK6 LMNA SREBF1 AXIN1 TCF7L1 PPARG HES1 ADIPOQ WNT10B CEBPB LEF1 SPP1 HES5 ZMPSTE24 CSNK1A1 RUNX2 APC CONTROL OF IMMUNE TOLERANCE BY VASOACTIVE INTESTINAL PEPTIDE%WIKIPATHWAYS_20260510%WP4484%HOMO SAPIENS Control of immune tolerance by vasoactive intestinal peptide IL2 IFNG IL5 CTLA4 CD80 CD28 IL4 FAS VIP IL10 TGFB1 CD86 IL12A SPHINGOLIPID METABOLISM INTEGRATED PATHWAY%WIKIPATHWAYS_20260510%WP4726%HOMO SAPIENS Sphingolipid metabolism integrated pathway CERS1 CERS2 SGPL1 SPTLC1 SMPD1 SPHK2 SGPP2 SGPP1 DEGS1 DEGS2 PLPP3 PLPP2 PLPP1 CERS3 CERS4 CERS5 ASAH1 CERS6 CERK SGMS1 SPHK1 SGMS2 UGT8 UGCG KDSR VASOPRESSIN REGULATED WATER REABSORPTION%WIKIPATHWAYS_20260510%WP5085%HOMO SAPIENS Vasopressin regulated water reabsorption ADCY9 DYNC1LI1 ARHGDIA ADCY3 RAB5C DCTN6 DCTN5 ADCY6 RAB5B DCTN2 DCTN1 PRKACB-1 DCTN4 ARHGDIG AQP2 ARHGDIB STX4 DYNC1I1 CREB1 NSF AVPR2 RAB11A RAB11B DYNC2H1 DYNC1LI2 AVP RAB5A CREB3L3 DYNC1I2 CREB3L4 CREB3L1 CREB3L2 VAMP2 AQP4 CREB3 DYNC1H1 DYNC2LI1 CREB5 PRKACA-1 AQP3 GNAS-1 EFFECT OF DASATINIB ON THE BCR ABL SIGNALING PATHWAY%WIKIPATHWAYS_20260510%WP5493%HOMO SAPIENS Effect of dasatinib on the BCR ABL signaling pathway KRAS GRB2 HSPB1 SHC1-1 ATF2 BCL2 HSPB2 VAV1 ARAF CRKL AKT2 AKT3 MEF2C MAP3K2 EIF4B HRAS AKT1 PIK3CA CRK MAPK1 SHC4 SHC3 RAF1 SHC2 CBL PXN PIK3R1 MAPK11 NRAS SOS1 BCAR1 BCLAF1 BCR SPAG1 SRC ABL1 RPS6KA1 MAPK3 GAB2 DOK1 INPP5D BRAF MAPK14 BCL9 PTK2 EXRNA MECHANISM OF ACTION AND BIOGENESIS%WIKIPATHWAYS_20260510%WP2805%HOMO SAPIENS exRNA mechanism of action and biogenesis ERI1 XPO5 AGO2 DGCR8 DROSHA DICER1 MONOAMINE GPCRS%WIKIPATHWAYS_20260510%WP58%HOMO SAPIENS Monoamine GPCRs ADRB3 ADRB1 ADRB2 HTR2A HTR1E HTR1F DRD4 HTR1D HTR1A HTR1B CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 HTR2B HTR4 HRH1 HTR6 HTR7 HRH2 DRD5 ADRA2C HTR5A ADRA2B ADRA1D ADRA2A ADRA1B ADRA1A DRD1 DRD2 DRD3 DOPAMINERGIC NEUROGENESIS%WIKIPATHWAYS_20260510%WP2855%HOMO SAPIENS Dopaminergic neurogenesis SOX2 NEUROG2 NR4A2 FGF8 SLC18A2 RET NEUROD1 ASCL1 CDKN1C DDC SHH TH WNT1 GBX2 FOXA2 SLC6A3 OTX2 MSX1 TGFB1 NKX6-1 NKX2-2 STAT3 GLI1 PITX3 EN2 GLI2 EN1 LMX1A ALDH1A1 LMX1B AUTOSOMAL RECESSIVE OSTEOPETROSIS PATHWAYS%WIKIPATHWAYS_20260510%WP4788%HOMO SAPIENS Autosomal recessive osteopetrosis pathways CLCN7 OSTM1 PLEKHM1 IKBKB SNX10 TCIRG1 RAB7A TRAF6 TNFRSF11A NFKB1 TNFSF11 RENIN ANGIOTENSIN SYSTEM AND BRADYKININ PATHWAYS IN COVID 19%WIKIPATHWAYS_20260510%WP4969%HOMO SAPIENS Renin Angiotensin System and Bradykinin pathways in COVID 19 ACE2 BDKRB2 NOS1 BDKRB1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 KLK1 CYP24A1 REN F12 KLKB1 IL1B SERPINE1 CPN1 ROCK1 MAPK1 NFKB1 RHOA VDR IL1A AGTR1 SERPING1 AGTR2 NPR1 TNF PRKG1 ACE KNG1 NOS3 AGT GPR143 IN MELANOCYTES AND RETINAL PIGMENT EPITHELIUM CELLS%WIKIPATHWAYS_20260510%WP4941%HOMO SAPIENS GPR143 in melanocytes and retinal pigment epithelium cells ADCY9 POMC PLCB3 ITPR1 PMEL TYRP1 MLANA GPR143 MC1R ADCY4 DCT PLCB1 ADCY2 MITF VEGFA PRKACB-1 CREB1 GNAQ SERPINF1 PLCB4 GNA15 TYR PLCB2 ARRB1 ARRB2 PRKCB ASIP PRKACA-1 GNAS-1 5Q35 COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5380%HOMO SAPIENS 5q35 copy number variation PTH SLC34A1 H3-3A F12 EED NTN1 BRCA1 KIAA1191 CAPN3 ARL10 RNF44 UNC5A TPM2 MYO7B JUN HIC2 DOK3 GPRIN1 PFN3 MAGED1 ABHD5 PRELID1 PTPRN2 NOP16 HIGD2A MXD3 PRR7 HIP1 FAF2 DDX41 BABAM1 BABAM2 NELFB TMED2-1 TMED9 ARFGAP2 CDHR2 FAM193B CDHR5 B4GALT7 DBN1 LMAN2 RAB24 ZNF346 SNCB PDLIM7 SNCA HIP1R SIMC1 TSPAN17 ANKS4B INPP5D PTPN2 NSD1 COX7B COX4I1 COX5B COX6A1 CLTB COX7C COX5A UIMC1 COX8A COX6C COX6B1 ABRAXAS1 BRCC3 GRK6 KDM6B FBXW7 BARD1 MAX FGF19 EIF4E1B IGF1R MYC RGS14 GNAI3 GNAI1 GNAI2 SOS1 SRC GRIN2B GRIN1 HK3 GRB2 CYP7A1 FGFR4 GAB1 TMED10 ADAM10 PIK3R1 USH1C MAPK10 FGF1 MAPK9 FRS2 CXCR4 MAPK8 ABL1 PLCG1 DRD2 PNPLA2 VITAMIN K METABOLISM AND ACTIVATION OF DEPENDENT PROTEINS%WIKIPATHWAYS_20260510%WP5186%HOMO SAPIENS Vitamin K metabolism and activation of dependent proteins F9 GGCX F10 NQO1 AIFM2 F7 PROS1 F2 VKORC1 VKORC1L1 UBIAD1 PROC 15Q25 COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5408%HOMO SAPIENS 15q25 copy number variation SH3GL3 RAMAC ZNF592 AGAP2 ADAMTSL3;ADAMTSL1 TENT4B AP3D1 ITPR1 AP3M2 BTBD1 C15orf40 FSD2 WHAMM SEC11A RNMT NMB HOMER2 NMBR WDR73 TM6SF1 AP3B2 AP3S2;AP3S1 DNM3 SPCS3 SPCS2 SPCS1 SYNJ1 ALPK3 TOP1 RAF1 SLC28A1 ZSCAN2 SHANK1 PDE8A CPEB1 EGF GRM1 GRM5 BNC1 RYR1 RYR2 HTT SHANK3 SLC2A1 NON CLASSICAL ROLE OF VITAMIN D%WIKIPATHWAYS_20260510%WP5133%HOMO SAPIENS Non classical role of vitamin D ACE2 AGTR1 AGTR2 CYP27B1 REN CYP2R1 ACE AGT PHOTODYNAMIC THERAPY INDUCED AP 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260510%WP3611%HOMO SAPIENS Photodynamic therapy induced AP 1 survival signaling IL2 ATF2 CCND1 CDKN2A BCL2 PDGFRA JUN TRAF6 NFE2L2 TRAF2 MCL1 FASLG TRAF5 MAPK12 MAP2K6 MAPK11 BCL2L11 TP53 BID BCL2L1 MAP2K3 EGFR CCNA2-1 TNF MMP2 IL6 ELK1 MAP2K4 FGF7 JUNB MAP3K5 HSP90AA1 HBEGF FOS TNFSF10 IFNG BMF MAP2K7 BCL3 TNFRSF1A BAK1 BAX MAPK8 MAPK13 CCNE1 FAS RB1 MAPK14 CFLAR CDKN1A 15Q11Q13 COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5407%HOMO SAPIENS 15q11q13 copy number variation DNMBP APBA2 TJP3 TJP2 FANCI CREBBP KAT2B SERPINH1 STXBP1 GJA1 HDAC1 APP SIN3A FANCD2 GJC2 OCLN-1 MITF MTMR10 SPEF1 OTUD7A SMC5 SMC6 ANKRD2 KLF13 CXADR NSMCE3 RELA NSMCE2 NSMCE1 CALM1 EID3 GJD3 CANX FAN1 STX1A NECAB3 CHRNA7;CHRFAM7A CCL5 LYPD6 TRPM1 UBN1 GCOM1;MYZAP TRPM3 RIC3 SLF1 SLF2 FAM189A1 CDC42BPB TJP1 CGN TNF ALPHA SIGNALING%WIKIPATHWAYS_20260510%WP231%HOMO SAPIENS TNF alpha signaling TRAF1 SKP1 TNFAIP3 TAB1 SMPD2 PSMD2 GLUL RIPK3 FBXW11 KSR2 TNFRSF1B PTPRCAP BIRC2 OTUD7B NSMAF TRADD NOXO1 RFFL TRAP1 NFKBIB CUL1 HRAS CREBBP IKBKB NFKBIA KSR1 JUN MAP3K1 NFKB2 CHUK BIRC3 MAP3K8 BTRC MAPK1 IKBKG TRAF2 APAF1 RAF1 MADD MAP3K14 MAP4K2 NFKB1 MAP2K6 CASP7 TANK CASP8 SOS1 RIPK1 FADD PLK1 BID BCL2L1 MAP2K3 MAP3K7 TNF TAB2 RFK PYGL REL KRAS GRB2 TBK1 NFKBIE NOX1 CYBA MAP2K4 CASP9 PRKCZ MAP3K3 RAC1 TAB3 CASP3 AKT1 MAP3K5 HSP90AA1 TXN NRAS MAP2K7 TNFRSF1A CDC37 BAD MAPK9 DIABLO-1 BAX MAPK8 PPP2CB;PPP2CA CSNK2A1;CSNK2A3 MAPK3 CFLAR GDNF RET SIGNALING AXIS%WIKIPATHWAYS_20260510%WP4830%HOMO SAPIENS GDNF RET signaling axis GDNF SOX11 IFT27 CTNNB1 PAX2 SIX2 ROBO2 HSPB11 ALDH1A2 FOXC1 SPRY1 HOXD11 SLIT2 HOXC11 HOXA11 ROBO1 SALL1 EYA1 HNF1B WT1 GFRA1 GREM1 RET LHX1 FAT4 GATA3 AGTR2 FOXC2 SOX17 BMP4 GLI3 EMBRYONIC STEM CELL PLURIPOTENCY PATHWAYS%WIKIPATHWAYS_20260510%WP3931%HOMO SAPIENS Embryonic stem cell pluripotency pathways CTNNB1 DVL1 DVL2 DVL3 AXIN1 HNF1A JUN IL6ST MAPK1 RAF1 MAP2K6 SMAD4 MAP2K3 MAP2K5 FGF2 FGF3 FGF4 FGF5 FGF6 FGF7 SELENOP FGF8 FGF9 PDGFB FGF20 FGF23 FGF22 FGF21 FGF17 SMAD1 FGF16 SMAD9 FGF14 SMAD5 FGF19 FGF18 FGF13 FGF12 WNT4 FGF11 FGF10 PTEN PIK3CD AKT2 AKT3 HRAS PDGFRB PDGFRA MAPK6 ACVR1 MAPK4 MAPK12 ACTR2 ERAS ACVR2B SOS1 BMPR1B MDM2-2 BMPR1A JAK1 BMPR2 LRP5 EGFR LRP6 WNT1 FZD6 STAT3 MTOR APC GRB2 FGFR4 FGFR3 FGFR2 FGFR1 ARAF GSK3B ELK1 GAB1 WNT2B AKT1 WNT5B LIFR WNT9B NOG WNT16 FOS PIK3R2 LIF WNT6 SMAD6 SMAD7 WNT11 WNT2 WNT3 WNT10B WNT10A FZD3 EGF FZD2 FZD5 FZD4 WNT3A WNT7B PTPN11 PDGFA FZD7 FGF1 FZD9 WNT7A FZD8 FZD1 MAP2K2;MAP2K1 WNT5A MAPK7 BMP4 BRAF 2Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP5223%HOMO SAPIENS 2q21 1 copy number variation syndrome AMER3 CCDC42 PLEKHB2 MZT2A;MZT2B STMN2 FAM168B GPR148 ARHGEF4 RAC1 STAT3 APC RHOA CDC27 SULFATION BIOTRANSFORMATION REACTION%WIKIPATHWAYS_20260510%WP692%HOMO SAPIENS Sulfation biotransformation reaction SULT1C3 SULT1C2 SULT2A1-4 PAPSS2 SULT2B1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 PAPSS1 G6PD GSR SULT4A1 SULT6B1 SULT1B1-1 GAMMA GLUTAMYL CYCLE FOR THE BIOSYNTHESIS AND DEGRADATION OF GLUTATHIONE%WIKIPATHWAYS_20260510%WP4518%HOMO SAPIENS Gamma glutamyl cycle for the biosynthesis and degradation of glutathione DPEP1 GGT1 GSS GGCT OPLAH GCLC STING PATHWAY IN KAWASAKI LIKE DISEASE AND COVID 19%WIKIPATHWAYS_20260510%WP4961%HOMO SAPIENS STING pathway in Kawasaki like disease and COVID 19 CGAS REL TBK1 STING1 IKBKE IFNB1-4 NFKBIE IRF3 ITPR1 IL1B GSDMD RELA NLRX1 IKBKB NFKBIA NLRP3 CHUK IKBKG NFKB1 F3 GLYCOSAMINOGLYCAN SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260510%WP5395%HOMO SAPIENS Glycosaminoglycan synthesis in fibroblasts CHST11 CHST12 CHST13 CHST14 B3GALT6 CHST1 HS2ST1 EXT1 EXT2 HS3ST3B1 CHST7 CHPF CHST3 XYLT2 EXTL2 XYLT1 HS6ST1 EXTL1 B4GALT7 HS6ST2 DSE CHST15 HS6ST3 CHSY3 NDST2 EXTL3 CSGALNACT1 CHPF2 NDST4 B3GAT3 NDST3 B3GAT2 GLCE B3GAT1 CSGALNACT2 CHSY1-1 NDST1 HS3ST1 UST HS3ST2 HS3ST3A1 HINT1 PATHWAY%WIKIPATHWAYS_20260510%WP5523%HOMO SAPIENS HINT1 pathway HINT1 GTF2H1 RUVBL2 RUVBL1 GTF2H3 GTF2H4 NFATC2 CDK7 ERCC3 ERCC2 CTNNB1 TCF4 MNAT1 MAPK9 JUN MITF CCNH GTF2H2C;GTF2H2C_2;GTF2H2 KARS1 FOS USF2 NFKB1 SH3RF1 ACUTE VIRAL MYOCARDITIS%WIKIPATHWAYS_20260510%WP4298%HOMO SAPIENS Acute viral myocarditis IL2 RAC3 FYN CCND1 RASA1 BCL2 AIF1 EDN1 DAG1 NFKB2 MAPK1 CAV1 CASP7 CD40LG CASP8 SOS1 NOD2 BID BCL2L1 LAMA2 SRC JAK1 CCR5 STAT1 CASP1 TNF STAT3 EIF4G1 MMP9 NOS1 IL6 CAAP1 ITGAL PYCARD SGCD SGCA TICAM1 CASP6 SGCB ITGB2 CASP2 SGCG TLR3 CD80 PTCRA GSK3B DFFB DFFA ENDOG KRT8 CASP9 MYH6 CHRAC1 BNIP2 CASP3 DMD ILK AKT1 PABPC1;PABPC3 EIF4G2 PARP1 IL12B IL12A PIK3R1 CREB1 IFNG ABL2 TLR5 TLR4 CYCS-1 CXADR HLA-DMA CD55 BAX CXCR4 CD4 SOCS1 ABL1 MAPK3 IL10 TGFB1 CCR3 ACTB-1 BIOTIN METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260510%WP5031%HOMO SAPIENS Biotin metabolism including IMDs PCCA MCCC2 PCCB BTD HLCS ACACB MCCC1 ACACA PC GANGLIO SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260510%WP1423%HOMO SAPIENS Ganglio sphingolipid metabolism B3GALT4 ST8SIA5 ST3GAL5 B4GALNT1 ST3GAL1 ST3GAL2 SLC33A1 ST8SIA3 FUT1 ST8SIA1 B3GALT1 A3GALT2 ST6GALNAC6 PHYSICO CHEMICAL FEATURES AND TOXICITY ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260510%WP3680%HOMO SAPIENS Physico chemical features and toxicity associated pathways PIK3CG CTNNB1 MYC DVL1 AXIN1 ROCK2 JUN NEFL NEFM ERBB2 PFN3 MAPK1 RAF1 ACTR2 SOS1 GRIA1 SRC STAT5A EGFR CAMK1 ACTA1 FZD6 DAAM1 APC GPX1 NOS1 GRB2 SHC1-1 MYLK GSK3B NCK1 ELK1 MAP2K4 FZD10 AKT1 WNT16 MYL1 PFN1 TGFA CBL RHOA NEFH PFN2-1 WNT11 ACTR3-1 PAK1 ERBB4 FZD3 FZD2 FZD5 FZD4 FZD7 FN1 FZD9 CDKN1B MAPK8 FZD8 PPP2CB;PPP2CA MAP2K2;MAP2K1 FZD1 PLCG1 SOD1 CDKN1A PTK2 KALLMANN SYNDROME%WIKIPATHWAYS_20260510%WP5074%HOMO SAPIENS Kallmann syndrome PLXND1 GRB2 MYRF CHD7 LHB SEMA3E ANOS1-1 OLIG2 SOX10 FGFR1 PROKR2 TMEM98 PTPN11 ASCL1 PROK2 GNRH1 NEUROG1 FRS2 FGF8 MAP2K2;MAP2K1 AKT1 OTX2 PIK3CA MAPK1 KENNEDY PATHWAY FROM SPHINGOLIPIDS%WIKIPATHWAYS_20260510%WP3933%HOMO SAPIENS Kennedy pathway from sphingolipids PEMT PCYT1A CHKA SGPL1 CHPT1 PCYT1B CHKB PISD PCYT2 PTDSS2 PTDSS1 ETNK2 ETNK1 CEPT1 UREA CYCLE AND ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260510%WP4595%HOMO SAPIENS Urea cycle and associated pathways ARG1 GLUD1;GLUD2 NOS1 ASS1 ASL GOT1-1 NAGS GLS2 GOT2-1 MDH2 FH CPS1 MDH1 SLC25A15 LDHB SLC25A12 OTC SLC25A13 NOS3 ALDH4A1 OAT NOS2 PYCR1 GPT HLA C ALLOTYPES INTERACTIONS WITH KIR ON DNK CELLS%WIKIPATHWAYS_20260510%WP5580%HOMO SAPIENS HLA C allotypes interactions with KIR on dNK cells IFNG PRKCQ FYN HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E ITPR1 VAV1 PTPN6 TYROBP SYK RAC1 TNF PLCG1 CSF2 LAT PRKCA ELF3 NLRP7;NLRP2 LCP2 PTPN2 TGF BETA RECEPTOR SIGNALING IN SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260510%WP4816%HOMO SAPIENS TGF beta receptor signaling in skeletal dysplasias EP300 TGFBR2 ZNF423 SERPINE1 CTNNB1 TGIF1-1 HRAS CREBBP JUN TFE3 NFKB1 SMAD2;SMAD3 SMAD4 JAK1 LEF1 FKBP1A WNT1 STAT1 TNF THBS1 STAT3 TGFBR3 TGFBR1-1 ZFYVE9 ITGB6 NOG FOXH1 RUNX3 ENG LTBP1 FOS SKIL LIF SMAD6 IFNG SMAD7 SKI BAMBI EGF SPP1 MAPK9 INHBA RUNX2 MAPK3 SMAD1 LEFTY2;LEFTY1 FST BMP4 ZEB2 TGFB1 SMAD9 SMAD5 ADAMTSL2 LTBP3 ADAMTS10 FBN1 ASPIRIN PREVENTION OF CANCER METASTASIS%WIKIPATHWAYS_20260510%WP5518%HOMO SAPIENS Aspirin prevention of cancer metastasis TBXAS1 TBXA2R GNA13 PTGS1 GNA12 ARHGEF1 RHOA ISOGLOBO SERIES SPHINGOLIPIDS%WIKIPATHWAYS_20260510%WP5311%HOMO SAPIENS Isoglobo series sphingolipids B3GALT5 KCNQ2 RELATED EPILEPSIES%WIKIPATHWAYS_20260510%WP5360%HOMO SAPIENS KCNQ2 related epilepsies PPP1R10 CHRM1 ANK3 BDKRB2 P2RY1 SCN1B BACE1 ITPR1 AKAP5 CALM1 KCNQ2 KCNQ3 AGTR1 STX1A PLCG2 CSNK2A1;CSNK2A3 PRKCA PRKACA-1 PPP3CC GDNF SIGNALING%WIKIPATHWAYS_20260510%WP5143%HOMO SAPIENS GDNF signaling FMOD MOLYBDENUM COFACTOR MOCO BIOSYNTHESIS%WIKIPATHWAYS_20260510%WP4507%HOMO SAPIENS Molybdenum cofactor Moco biosynthesis AOX1 XDH MOCS2 MTARC2 MOCS1 GPHN SUOX NSAIDS MECHANISM OF ACTION%WIKIPATHWAYS_20260510%WP5513%HOMO SAPIENS NSAIDs mechanism of action PTGS2-2 PTGS1 PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS %WIKIPATHWAYS_20260510%WP2572%HOMO SAPIENS Primary focal segmental glomerulosclerosis FSGS ITGAV FYN CAMK2B SCARB2 IRF6 PTPRO CTNNB1 MKI67 CLDN1 SYNPO KIRREL3 PAX2 TRPC6 NOTCH1 KIRREL2 MME PLAUR ACTN4 CD2AP INF2 JAG1 MYH9 DAG1 UTRN COL4A4 PARVA FAT1 COL4A3 MYO1E ITGB4 LIMS4;LIMS1 COL4A5 PODXL NPHS1 NPHS2 LRP5 VIM CDKN1C TLN1 LRP6 LAMB2 WNT1 VTN PCNA ITGA3 CTSV;CTSL SMARCAL1 CD80 CD151 NCK1 KRT8 AGRN ILK AKT1 WT1 DNM1 VCL PLCE1 CDH2 TLR4 ITGB1 LAMA5 CR1L;CR1 CDKN1B PLCG1 TGFB1 DKK1 ITGB3 YWHAQ CDKN1A LMX1B PTK2 METABOLIC EPILEPTIC DISORDERS%WIKIPATHWAYS_20260510%WP5355%HOMO SAPIENS Metabolic epileptic disorders ARG1 ASS1 MOCS2 MOCS1 ASL GPHN HK2 PDHA1 MDH1 PFKL G6PC1 MOCS3 PC SLC2A5 ENO2 ENO3 ACO1 DHTKD1 DLAT MPC1 PCK1 MPC2 PFKP AASS ALDOC SLC25A5 SFXN1 SLC25A1 FBP2 GCDH SLC7A2 GLS2 PKLR ECHS1 AADAT SQOR GCK LDHA;LDHC ALDH7A1 CDO1 LDHAL6B ACAT1 GLDC SLC1A5 CPS1 SHMT1 HK3 HADH AMT OTC GPI PGAM1 TPI1 PGAM2 SLC2A1 CBS;CBSL GPT ENO1 DLD HK1 LDHA GLUD1;GLUD2 GAPDH-1 PKM ALDOB XDH PGK1 ALDOA PFKM SLC2A4 GOT1-1 ETHE1 GOT2-1 MDH2 SUOX SHMT2 PSAT1 SLC2A2 PHGDH PSPH CTH GAMT GATM BTD HLCS SPCS1 SLC25A15 LDHB FBP1 TRANSCRIPTION ACTIVATION RNA POLYMERASE I AND KAT2A B AND INHIBITION NURD COMPLEX %WIKIPATHWAYS_20260510%WP5565%HOMO SAPIENS Transcription activation RNA polymerase I and KAT2A B and inhibition NuRD complex EP300 CREBBP KAT2B CHD3 GATAD2B MTA2 PWWP2B CHD4 H2AC14 H2BC21 TLK2 UBTF PWWP2A KAT2A HAT1 ASF1A ASF1B RRN3 TAF1D TAF1B TAF1C HDAC2 TAF1A H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H4C1 HDAC1 EP400 MBD3 H4C6 H2BC5 TAF12 MBD2 H2AB2;H2AB3;H2AB1 H2BC1 GATAD2A H4-16 H2BC15;H2BC3;H2BC11;H2BC12 H2AC20 CDK2AP1 H2AZ2;H2AZ1 MTA1 POLR1A POLR1B POLR1C POLR1D SRCAP MAPK3 TBP RBBP4 NANOMATERIAL INDUCED INFLAMMASOME ACTIVATION%WIKIPATHWAYS_20260510%WP3890%HOMO SAPIENS Nanomaterial induced inflammasome activation CASP1 PYCARD TLR4 NOX1 IL1B CTSB NFKB1 ENDOCHONDRAL OSSIFICATION%WIKIPATHWAYS_20260510%WP474%HOMO SAPIENS Endochondral ossification PTH CHST11 IGF1R ALPL PTCH1 MEF2C ADAMTS1 VEGFA FRZB SERPINH1 HMGCS1-1 BMP7 TGFB2 BMP6 IGF2 IFT88 BMPR1A CDKN1C STAT5B STAT1 PLAU KIF3A MMP9 CTSV;CTSL FGFR3 FGF2 FGFR1 IGF1 ADAMTS4 ADAMTS5 TIMP3 GHR NKX3-2 PLAT SOX5 CAB39 SCIN SLC38A2 AKT1 MGP SOX6 RUNX3 COL10A1 SOX9 MMP13 COL2A1 DDR2 HDAC4 ACAN SPP1 CALM1 ENPP1 RUNX2 TGFB1 THRA GLI3 PRKACA-1 FGF18 IHH PTH1R PTHLH SCFA AND SKELETAL MUSCLE SUBSTRATE METABOLISM%WIKIPATHWAYS_20260510%WP4030%HOMO SAPIENS SCFA and skeletal muscle substrate metabolism GCG PYY FFAR3;GPR42 FFAR2 SLC2A4 PPARD MICROTUBULE CYTOSKELETON REGULATION%WIKIPATHWAYS_20260510%WP2038%HOMO SAPIENS Microtubule cytoskeleton regulation PTEN MARK2 PTPRA MARK1 DVL1 GSK3B RAC1 ROCK1 CFL2 STMN1 AKT1 TESK2 AURKB CDC42 MAPKAPK2 MAPRE1-1 TPPP CLASP1 CLIP1 TAOK1 MAP1B LIMK1 KIF2C PHLDB2 PAK1 GNAQ DPYSL2 TRIO PARD6A SRC SPRED1 EPHB2 WNT3A CDK1 CAMK4 RHO TIAM1 F2RL2 NTRK1 ABL1 NTRK2 MAPT DIAPH1 STAT3 PRKCA PRKACA-1 NTRK3 APC POLYOL PATHWAY%WIKIPATHWAYS_20260510%WP690%HOMO SAPIENS Polyol pathway SORD ALDOB AKR1B1 KHK FTO OBESITY VARIANT MECHANISM%WIKIPATHWAYS_20260510%WP3407%HOMO SAPIENS FTO obesity variant mechanism FTO TBX1 IRX3 ARID5B PPARGC1A PRDM16 UCP1 IRX5 GLYCEROL METABOLISM INCLUDING LINKED IMDS%WIKIPATHWAYS_20260510%WP5570%HOMO SAPIENS Glycerol metabolism including linked IMDs HK1 GAPDH-1 ALDOB PGK1 ALDOA PFKL G6PC1 PC KHK PCK1 AKR1A1 SDS GK GLYCTK LOC100509620;LOC112267859;AQP7 AGXT PKLR GRHPR GPD2 LIPE GPD1 MGLL GPI PGAM1 TPI1 AQP9 FBP1 ENO1 PNPLA2 DIRECT REVERSAL REPAIR%WIKIPATHWAYS_20260510%WP4931%HOMO SAPIENS Direct reversal repair ALKBH3 ALKBH2 MGMT DDX1 AS A REGULATORY COMPONENT OF THE DROSHA MICROPROCESSOR%WIKIPATHWAYS_20260510%WP2942%HOMO SAPIENS DDX1 as a regulatory component of the Drosha microprocessor RAD50 ATM DDX1 NBN DGCR8 DROSHA MRE11 FACTORS AND PATHWAYS AFFECTING INSULIN LIKE GROWTH FACTOR IGF1 AKT SIGNALING%WIKIPATHWAYS_20260510%WP3850%HOMO SAPIENS Factors and pathways affecting insulin like growth factor IGF1 Akt signaling PTEN PIK3CG IGF1R RPTOR DEPTOR IGF1 GSK3B MAP1LC3A MLST8 IRS1 MAPKAP1 WASL RICTOR ILK AKT1 EIF4E EIF2B2 NFKB1 AKT1S1 SMAD2;SMAD3 ACVR2B PRKAB1 IGFBP5 TNFSF9 PPARGC1A TNFRSF1A ITGB1 PDK1 MSTN TRIM63 NEB FBXO32 RPS6KB1 PLD1 MTOR GNAQ P R183Q DRIVES CAPILLARY MALFORMATION%WIKIPATHWAYS_20260510%WP5501%HOMO SAPIENS GNAQ p R183Q drives capillary malformation PRKD3 PLCB3 GNAQ PRKCQ PPP3R1 PRKD1 NFATC1 PRKCZ PRKD2 PKN3 PKN2 PRKCG PKN1 PRKCH PRKCB PRKCE RCAN1 PPP3CB ANGPT2 PRKCD PRKCA PRKCI PPP3CA PPP3CC SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260510%WP4658%HOMO SAPIENS Small cell lung cancer TRAF1 ITGAV ITGA2 TRAF4 PTEN SKP1 PIK3CD RXRB PIK3CB RXRG CCNE2 PTGS2-2 CCND1 BCL2 MYC RARB BIRC2 AKT2 AKT3 CDK6 NFKBIB CDK4 IKBKB COL4A2 NFKBIA COL4A1 CHUK PIK3CA COL4A4 BIRC3 TRAF6 COL4A3 COL4A6 BIRC7 IKBKG TRAF2 COL4A5 APAF1 NOS2 TRAF5 NFKB1 ZBTB17 LAMC3 CASP8 LAMC2 CKS1B TP53 BID BCL2L1 LAMA2 CDK2 LAMA1 LAMA4 LAMA3 CDKN1C LAMB3 LAMB2 LAMB4 LAMC1 LAMB1 ITGA3 TRAF3 RXRA ITGA6 CDKN2B FHIT CASP9 CASP3 POLK AKT1 DDB2 PIK3R3 PIK3R2 PIK3R1 E2F1 CYCS-1 E2F2 E2F3 BAK1 ITGB1 GADD45B LAMA5 RELA GADD45A FN1 GADD45G BAX CDKN1B ITGA2B CCNE1 RB1 CKS2 MAX CDKN1A PTK2 BIOSYNTHESIS AND TURNOVER OF 1 DEOXY SPHINGOID BASES%WIKIPATHWAYS_20260510%WP5179%HOMO SAPIENS Biosynthesis and turnover of 1 deoxy sphingoid bases SGPP2 SGPP1 ASAH1 SPHK1 SPTLC1 KDSR SPHK2 ROBO4 AND VEGF SIGNALING CROSSTALK%WIKIPATHWAYS_20260510%WP3943%HOMO SAPIENS ROBO4 and VEGF signaling crosstalk KDR RAC1 SLIT2 VEGFA ROBO4 SRC OXIDATIVE DAMAGE RESPONSE%WIKIPATHWAYS_20260510%WP3941%HOMO SAPIENS Oxidative damage response TRAF1 PCNA MAP3K9 TRAF3 NFKBIE BCL2 TNFRSF1B MAP2K4 CASP9 CR2 CASP3 MAP3K1 CDC42 TRAF6 C1QB TRAF2 APAF1 NFKB1 C1S C1R CYCS-1 BAK1 MAPK10 C3AR1 LOC110384692;C4A;C4B_2;C4B BAD GADD45A CDKN1C CDKN1B MAPK13 TNF C1QC BAG4 C5AR1 TNK2 TDP2 C2 C5 CDKN1A DUAL HIJACK MODEL OF VIF IN HIV INFECTION%WIKIPATHWAYS_20260510%WP3300%HOMO SAPIENS Dual hijack model of Vif in HIV infection RUNX1 ELOB RBX1 CBFB CUL5 UBB;UBC ELOC-1 MFAP5 MEDIATED OVARIAN CANCER CELL MOTILITY AND INVASIVENESS%WIKIPATHWAYS_20260510%WP3301%HOMO SAPIENS MFAP5 mediated ovarian cancer cell motility and invasiveness CREB1 ITGAV PRKCQ ITPR3 PLCG1 JUN MAPK3 RYR3 MAPK1 ITGB3 TNNC1 PTK2 MFAP5 GLYCOGEN SYNTHESIS AND DEGRADATION%WIKIPATHWAYS_20260510%WP500%HOMO SAPIENS Glycogen synthesis and degradation PYGM PYGL HK1 GYS2 UGP2 PPP2R1B PTPA PHKG1 GYG2 PPP2R1A GYG1 PGM1 PPP2R5B PPP2R5A PPP2R5D PPP2R3B PHKB PHKA1 PPP2R3A PHKA2 GSK3B PPP2R2C PPP2R2B HK2 HKDC1 PPP2R2A;PPP2R2D AGL-1 GYS1 GSK3A CALM3;CALM1 CALM1 CALM2 PPP2CB;PPP2CA HK3 PPP2R5E PHKG2 PPP2R5C PYGB GBE1 LINOLEIC ACID METABOLISM AFFECTED BY SARS COV 2%WIKIPATHWAYS_20260510%WP4853%HOMO SAPIENS Linoleic acid metabolism affected by SARS CoV 2 FADS2 ACE2 FADS1 ACOT2;ACOT1 ELOVL5 ELOVL2 MRNA PROTEIN AND METABOLITE INDUCED STRESS PATHWAY BY CYCLOSPORIN A%WIKIPATHWAYS_20260510%WP3953%HOMO SAPIENS mRNA protein and metabolite induced stress pathway by cyclosporin A KEAP1 SLC1A5 ATF4 SLC7A5 NFE2L2 SLC3A2 SLC7A11 SOMITOGENESIS IN THE CONTEXT OF SPONDYLOCOSTAL DYSOSTOSIS%WIKIPATHWAYS_20260510%WP4785%HOMO SAPIENS Somitogenesis in the context of spondylocostal dysostosis HES7 DLL1 MESP2 EPHA4 LFNG DLL3 RIPPLY2 TBX6 NOTCH1 MBDNF AND PROBDNF REGULATION OF GABA NEUROTRANSMISSION%WIKIPATHWAYS_20260510%WP4829%HOMO SAPIENS mBDNF and proBDNF regulation of GABA neurotransmission GABRQ GABRA2 PTEN GABRA1 GABRP PIK3CB SLC12A5 PIK3CG GABRA6 GABRA5 SHC1-1 GABRA4 GABRA3 JAK2 ROCK1 AP2A1 AP2A2 PIK3CA AP2B1 PIK3R3 PIK3R2 RHOA PIK3R1 CREB1 GABRG1 BDNF GABRB3 GABRB2 GABRB1 NGFR PLCG1 NTRK2 GABRG3;GABRG2 CREM STAT3 GABRE GABRD NEOLACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260510%WP5302%HOMO SAPIENS Neolacto series sphingolipid metabolism B4GALT1 ST3GAL4 NEU2 B4GALT3 B4GALT4 B3GNT5 FUCA1 NAGA FUT1 FUT2 FUT6;FUT5;FUT3 BURN WOUND HEALING%WIKIPATHWAYS_20260510%WP5055%HOMO SAPIENS Burn wound healing HGF CXCL12 ICAM1 BCL2 MMP1 TIMP1 PDGFRB SCEL VEGFA CXCL2;CXCL3;CXCL1-1 SERPINH1 NFKB1 SMAD2;SMAD3 ACHE FOXE1 TGFB2 HEXD CXCR2 KLF4 TNC TGFB3 F13A1 LGALS1 TP53 IFNB1-4 MMP28 KRT222 S100A11 COL1A2 BRD4 NOX4 AMBP PECAM1 SLURP1 LIN28A TPT1 CDK16 KRT6B;KRT6C;KRT6A ACTA1 TNF S100A6 SFRP2 MMP2 MMP9 IL6 FGFR4 FGFR3 FGFR2 MYD88 FGFR1 IL1B CXCL8 CASP3 AKT1 CD3E TLR4 EGF HMGB1-1 CCL13;CCL2 BAX CXCR4 COL1A1 CHRNA7;CHRFAM7A INHBA FST S100A9 DCN SNAI2 IL15 FBN1 17Q12 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP5287%HOMO SAPIENS 17q12 copy number variation syndrome CCL3L1;CCL3L3;CCL3;CCL18 RFFL CCL23;CCL15 HNF1B ERBB2 AP2B1 CCL11 LHX1 CCL1 MMP28 PNMT DHRS11 PGAP3 SLC35G4;SLC35G5;SLC35G3;SLC35G6 CWC25 SLFN11;SLFN13 AATF PIGW IKZF3 CISD3 CCT6B DUSP14 GRB7 RDM1 LASP1 ARL5C C17orf98 CACNB1 TEC C17orf50 GPR179 UNC45B MED1 RPL23 LIG3 LYZL6-1 DDX52 MRPL45 SRCIN1 FNDC8 PEX12 RAD51D SLFN14 ZNF830 CCL14 SLFN5 GGNBP2 FBXO47 MLLT6 FBXL20 NEUROD2 PPP1R1B MIEN1 ZNHIT3 C17orf78 PIP4K2B ASIC2 SOCS7 GAS2L2 CCL16 STARD3 HEATR9 TMEM132E TAF15 RASL10B PCGF2 SYNRG EPOP PLXDC1 MYO19 NLE1 ARHGAP23 TADA2A STAC2 SLFN12L;SLFN12-1 TCAP ACACA CDK12 CCL13;CCL2 CCL8 CCL4L2;CCL4L1;CCL4 CCL5 NRP1 TRIGGERED SIGNALING IN PANCREATIC CANCER %WIKIPATHWAYS_20260510%WP5144%HOMO SAPIENS NRP1 triggered signaling in pancreatic cancer FLT1 CDH5 HGF TGFBR2 CCNE2 AKT2 AKT3 KDR VEGFA NFKB2 MAPK1 NFKB1 SMAD2;SMAD3 TGFB2 SMAD4 TGFB3 MET BCAR1 GSK3A COL1A2 SRC CDK2 PECAM1 EGFR MMP2 MMP9 REL TGFBR3 TGFBR1-1 RAC1 AKT1 CCN2 SLC39A4 EGF RELB NRP1 RELA CHD1 SEMA3A PLXNA1 PLXNA4 CDKN1B COL1A1 MAP2K2;MAP2K1 CCNE1 MAPK3 CHD2 SNAI1 SNAI2 PLXNA2 PTK2 SELENIUM MICRONUTRIENT NETWORK%WIKIPATHWAYS_20260510%WP15%HOMO SAPIENS Selenium micronutrient network GPX4 ICAM1 LDLR MPO PTGS2-2 PTGS1 F2 SERPINE1 CRP HBD;HBB HBA2;HBA1 NFKB2 INS;INS-IGF2 GSR PRDX1 NFKB1 MTR-1 GGT1 ABCA1 TNF INSR SELENOK SERPINA3 SELENOI SAA2;SAA1 CBS;CBSL SEPHS2 APOA1 FLAD1 PNPO ALOX15B RFK FGB FGA GPX1 SAA2-SAA4;SAA4 TXNRD3 IL6 FGG XDH TXNRD2 GPX6 F7 PLG TXNRD1 DIO1 DIO3 ALB SELENOO IL1B SELENON SOD2 SELENOS CTH PLAT SELENOP CAT SELENOT TXN IFNG SOD3 RELA MTHFR CCL13;CCL2 APOB KYNU KMO PRDX3 PRDX2 PRDX5 PRDX4 SOD1 ALOX5AP ALOX5 SCARB1 NIFEDIPINE ACTIVITY%WIKIPATHWAYS_20260510%WP259%HOMO SAPIENS Nifedipine activity KDR PTK2B PCNA MAP2K2;MAP2K1 BDKRB2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SOD1 MAPK1 JAK STAT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260510%WP5528%HOMO SAPIENS JAK STAT signaling and ARTD family members HDAC2 SKP1 RBX1 STAT6 STAT1 CUL1 HDAC3 DTX3L PARP14 BTRC STAT3 PARP9 PARP11 PARP1 PATHOPHYSIOLOGICAL ROLES OF DUX4 IN FSHD1%WIKIPATHWAYS_20260510%WP5342%HOMO SAPIENS Pathophysiological roles of DUX4 in FSHD1 EP300 MYOD1 PPARGC1A MYC TRIM63 ADRB2 UPF1 FBXO32 VEGFA RET PAX7 DUX4;DUXA MYF5 MYOG CDKN1A ESR2 GENE REGULATORY NETWORK MODELING SOMITOGENESIS %WIKIPATHWAYS_20260510%WP2854%HOMO SAPIENS Gene regulatory network modeling somitogenesis HES7 FGF8 DLL1 MESP2 EPHA4 LFNG RIPPLY2 TBX6 WNT3A HES1 NOTCH1 RAS SIGNALING%WIKIPATHWAYS_20260510%WP4223%HOMO SAPIENS Ras signaling RIN1 PLA1A PLA2G3 RASAL1 RASAL2 RASGRP1 RASAL3 TTBK1 BRAP AFDN RASGRP2 RGL1 RGL2 RASA1 FOXO4 RASGRF2 RASA4;RASA4B PLA2G12A PLA2G4F PLA2G12B PLA2G4D PLA2G4E PLAAT3 RASA3 IKBKB RASA2 RAPGEF5 RAB5C PLA2G1B RRAS PLA2G2F CHUK PIK3CA PLA2G2D PLA2G2E MAPK1 PLA2G2C IKBKG RAF1 NFKB1 PRKCG PLA2G4A PRKCB GAB2 PRKCA RASSF1 SHOC2 RASSF5 STK4 RASGRF1 RALGDS GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 CALM1 CALM2 ARF6 GNG10 GNGT1 PRKACA-1 FLT1 FLT3 FLT4 PIK3CD RAC3 PIK3CB IGF1R RRAS2 KSR2 RALBP1-1 AKT2 MRAS AKT3 KDR HRAS PDGFRB ETS1 PDGFRA RALA-1 KSR1 CDC42 ZAP70 PRKACB-1 GNG2 RASGRP4 FASLG GNG5 PLD2 GNG4 PLA2G10;LOC100652777 RASGRP3 KIT GNG8 SOS1 SOS2 MET BCL2L1 EPHA2 EXOC2 CSF1R RALB RAP1A CALM3;CALM1 SYNGAP1 EGFR TIAM1 NTRK1 NGFR GRIN2B NTRK2 GRIN1 INSR REL KRAS GRB2 TEK FGFR4 FGFR3 FGFR2 SHC1-1 FGFR1 BUB1B-PAK6;PAK6 PLA2G6 CALML6 ETS2 CALML3 CALML4 ELK1 GAB1 RAC1 AKT1 RAB5B SHC4 SHC3 SHC2 PIK3R3 PIK3R2 RHOA PIK3R1 GRIN2A ABL2 PLCE1 NRAS PAK1 PAK3 PAK2 PAK5 PAK4 RAB5A MAPK10 BAD RELA PTPN11 RAP1B NF1 HTR7 MAPK9 PLA2G2A-1 MAPK8 MAP2K2;MAP2K1 PLCG2 ABL1 PLCG1 MAPK3 LAT PLD1 PLA2G5 JMJD7-PLA2G4B;PLA2G4B MIR TARGETED GENES IN MUSCLE CELL%WIKIPATHWAYS_20260510%WP2005%HOMO SAPIENS miR targeted genes in muscle cell CXCL12 ANAPC1 NF2 ARID1A CDK6 UHRF1 CSNK1D EZH2 SPARC CCNG1 MYO1E MTRR PODXL PLK1 IGF2R GJA1 RDH10 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A THBS1 ATAD3A;ATAD3B DNAJB1 SLC12A2 CYP51A1 SRF SLC38A2 CYP1B1 SNAP23 HES1 PHLDB2 TYMS POLD2 GPD2 HDAC4 PPP1R7 PKN2 ATP2A2 SH3BP4 ATG9A CBFB YWHAQ ITGA2 KCNQ1 CLDN1 IRS1 NCOA3 RAB27B ERBB2 MCL1 MAPK12 ANPEP LAMTOR3 HIPK3 PICALM MBNL1 LAMC1 PGRMC1 SPTLC1 SDCBP POLR2C SRSF9 TMED10 PRKCI NCL-1 ERBB3 CEBPB DNMT3A NRP1 CHD1 MTHFD2 COL1A1 PTPRF COL3A1 RHOG AXL WNT5A MAPK7 IGF2BP1 ZEB1 DHX15 MAPK14 ACAA2 TUSC2 PTBP2 ARID4B ARF4-1 TGFBR2 TXN2 ARHGDIA CHORDC1 BCL2 CDK5RAP1 CTNNB1 CDK5RAP3 VPS39 NOTCH2 IFRD1 NOTCH1 PISD RAB34 WDFY1 PPIF MATR3 TPM2 EIF4E SLC1A4 ESR1 ADIPOR2 RTN4 CORO1C ITGB4 CPNE8 MRPL20 SRSF10 VEZT RAB6A SRPRB-1 BACH1 PWP1 RAVER2 ATP6V0A1 ANKFY1 SNX6 CIAO2A CD164 SEC62 CCN1 TBCA TMEM41B-1 CACNA2D1 SFXN1 FNDC3B SLC25A1 FNDC3A TRAM1 SCAMP1 TMED2-1 DHX40 TNFAIP2 CARHSP1 ADAR METTL7A-1 LMNB2 WDR82 FAR1 MRC2 TMEM87A TMEM43 HACD3 CSRP1 UBE2J1 TMED3 COMMD9 TMEM109 GRPEL2 SH3BGRL3 EHMT2 ATP6V1C1 ACP2 MOV10 NELFCD PDLIM7 NCEH1 CTSC PDE3A SCYL1 STRN GAK ANP32B SLC7A6 EHMT1 GFM1 CDCP1 PTPRJ MAGT1 RFT1 PANX1 FRG1 COIL SLC7A11 C1QBP HYAL3 BRPF3-1 HMOX1 GNL3L-1 GNPNAT1 CAPG TMED7 PTPA MRPS24 SHOC2 ELMOD2 PGM1 CDIPT AP3B1 CA12 TXNRD1 VSNL1 SEC24A CSDE1 AP3D1 PXDN ARCN1 FGF2 AGO3;AGO1 WDR11 PTMA FMNL2 PAFAH1B2 ATP6V0E2;ATP6V0E1 AMIGO2 FSTL1 PSAT1 NAPG NT5E MPZL1 SPRYD4 TTC9C TM6SF1 TPPP3 GPAM NFIA SPCS3 NEDD4 CSF1 SNX15 NUCB1 LAMTOR5 LTN1 CPOX MYLIP USP1 LCLAT1 IPO4 ABHD10 POGLUT3 KPNA3 SLC38A1 RARS1 TPM4 ATRX TPM1 STX7 UBE4A CDKAL1 RAB30 DMTF1 GSTM4 SYPL1 GEMIN7 ASH2L ABCG2 RAI14 UAP1 SLC9A3R2 CAMTA1 SLC38A5 GFPT1 SLC4A10 TPM3 CHMP2A CALCOCO2 DOCK7 SYNE2 SYNE1 HSDL1 RCN2 RBMS1 DSG2 MTPN CDKN1A SEC23A LUZP1 LRP1 LPL NUFIP2 NXN HSD17B12 ERG ACVR1B RAD23B CAND1 TDG TP53INP1 LRRC8A ZNF622 CCND1 SLC25A24 GALNT7 SLC12A4 MYO10 GALNT1 CUL4B SLC4A7 FADS2 PDCD4 SLC25A32 NAA15 BET1 POLE4 POLA2 GNA13 KIT LAMC2 MET GRIA2 COL1A2 SSNA1 P4HA2 EGFR PPIB RHEB KRAS PKM G6PD PDLIM5 CNOT9 DOCK5 SNAP29 PPP3CA BACE1 E2F1 CLOCK E2F3 CDKN1B RB1 SLC25A13 CARDIOMYOCYTE SIGNALING CONVERGING ON TITIN%WIKIPATHWAYS_20260510%WP5344%HOMO SAPIENS Cardiomyocyte signaling converging on titin PRKAR1A FHL2 ADRB1 CAMK2A SRF ADRB2 GUCY1B1 FHL1 MYPN GUCD1 CSRP3 PLCZ1 NUP62 MAPK1 PRKACB-1 ANKRD1 ANKRD23 RAF1 TTN-1 NBR1 CRYAB TRIM55 ANKRD2 TCAP MDM2-2 TRIM63 MAP2K2;MAP2K1 NPR1 PRKG2 PRKCA PRKACA-1 GALANIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260510%WP4970%HOMO SAPIENS Galanin receptor pathway CREB1 POMC IL6 BCL2L11 SLC2A4 YAP1-1 VAMP2 CDKN1C CDKN1B CRP VEGFA INS;INS-IGF2 PPARG ADIPOQ FOS CDKN1A RETINOID METABOLISM IN RETINA HEALTHY VS RLBP1 DEFICIENT%WIKIPATHWAYS_20260510%WP5532%HOMO SAPIENS Retinoid metabolism in retina healthy vs RLBP1 deficient RLBP1 OVARIAN INFERTILITY%WIKIPATHWAYS_20260510%WP34%HOMO SAPIENS Ovarian infertility NR5A1 FSHR DMC1 PGR ZP3;POMZP3 SMPD1 CDK4 EGR1 CYP19A1 AKT1 TSC2 MLH1 TSC1 NCOR1 NRIP1 SMAD2;SMAD3 LHCGR CREB1 INHA DAZL ZP2 VDR GDF9 RAD51 CEBPB BMPR1B FMR1 PTGER2 GJA4 CDKN1B PRLR ATM SYNE2 TBP FIGLA MTOR CCND2 ESR2 MSH5 PSORIASIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260510%WP5537%HOMO SAPIENS Psoriasis mechanism and therapies IL23A IL17RC CCL20 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E IL1B CXCL8 IL22 IL23R JAK2 TNF IL17F CCR6 IL12RB1 IL17A STAT3 CXCL2;CXCL3;CXCL1-1 IL12B TYK2 BASE EXCISION REPAIR%WIKIPATHWAYS_20260510%WP4752%HOMO SAPIENS Base excision repair PCNA LIG3 TDG FEN1 POLB PARP3 PARP2 POLE4 POLE RFC5 RFC3 RFC4 APEX1 PARP1 POLE3 POLD4 MPG POLD1 TDP1 OGG1 POLD3 POLD2 PNKP UNG NTHL1 HMGB1-1 POLL MUTYH MBD4 PARP4 XRCC1 SMUG1 NEIL3 NEIL2 POLG2 APTX ADPRS NEIL1 POLG POLE2 RFC1 LIG1 RFC2 HIPPO MERLIN SIGNALING DYSREGULATION%WIKIPATHWAYS_20260510%WP4541%HOMO SAPIENS Hippo Merlin signaling dysregulation CDH5 CXCL10 CDH4 ITGAV CDH3 RBX1 TEAD4 SAV1 AJUBA PPP1R14A CTNNB1 NF2 PPP1CB CD44 ITGB4 VGLL4 AMOT STK3 YAP1-1 CDH20 CDH22 ITGA5 CDH24 LIN28B LATS1 LATS2 CDH10 CDH12 CDH13 CDH15 WWTR1 CDH16 CDH18 CDH19 PRKAR1B PRKAR1A FOXM1 PRKAR2B PRKAR2A ITGA10 ITGA2B PRKACA-1 FLT1 FLT3 ITGA2 FLT4 ITGB7 CUL4A IGF1R PPP1R12A DDB1 ITGA1 CTNNA1 CCND1 MYC MST1 KDR HRAS PDGFRB PDGFRA PRKACB-1 KIT MET EPHA2 CSF1R EGFR CDH11 CDH17 NTRK1 NGFR DCAF1 NTRK2 PPP1CC INSR ITGA11 ITGB5 ITGAE ITGB8 ITGAD ITGA8 ITGA7 ITGA9 KRAS ITGA3 TEK FGFR4 ITGAL FGFR3 FGFR2 FGFR1 ITGAM BUB1B-PAK6;PAK6 ITGB2 ITGA6 ITGAX CDH1 PPP1CA ITGB6 CCN2 NRAS PAK1 PAK3 CDH2 PAK2 PAK5 PAK4 ITGB1 PLCB4 TEAD1 TEAD2 TEAD3 CDH9 ITGA4 CDH8 ITGB3 CDH7 CDH6 PTK2 BARDET BIEDL SYNDROME%WIKIPATHWAYS_20260510%WP5234%HOMO SAPIENS Bardet Biedl syndrome PTCH1 KIF7 SMO BBIP1 DYNC2I2 DYNC2I1 TRAF3IP1 IFT172 DYNC2H1 IFT80 GPR161 LZTFL1 IFT81 WDPCP CEP104 ARL6 ARL3 DYNC2LI1 OCRL TTC21B INPP5E BBS2 ZIC2 BBS1 INVS CNGA1 IFT122 NEK1 SCAPER FUZ CFAP410 RP2 MAK NEK8 EFHC1 CNGB1 CRX MKS1 PKD1L1 CEP164 PKHD1 IFT27 PDE6D NPHP3 USP9X FLCN PCARE DCDC2 C8orf37 CEP41 IFT52 TRIM32 PKD2 TMEM107 PKD1 BBS9 CEP290 BBS7 IFT57 IQCB1 BBS5 BBS4 MKKS IFT140 EFHC2 WDR35 BBS10 IFT43 EVC BBS12 TMEM216 CILK1 DYNLT2B ARNTL LCA5 IFT74 ARL13B TMEM67 RAB23 EVC2 WDR19 SCLT1 TTC8 GLI3 GLI2 CLUAP1 GENES CONTROLLING NEPHROGENESIS%WIKIPATHWAYS_20260510%WP4823%HOMO SAPIENS Genes controlling nephrogenesis ITGA3 GDNF CXCL12 FGFR2 FOXD1 ETV4 CTNNB1 NOTCH2 TCF21 NCK2 PAX2 NCK1 KDR ROBO2 FOXC1 FGF8 HOXD11 SLIT2 KIRREL1 PDGFRB CD2AP MAFB ILK HOXA11 VEGFA CD36 EYA1 HNF1B WT1 NPHS1 RET NPHS2 LHX1 PDGFB MAGI2 ITGB1 SHH CXCR4 LAMB2 EMX2 FOXC2 SIX1 GLI3 ITGA8 WNT4 LMX1B DEVELOPMENT AND HETEROGENEITY OF THE ILC FAMILY%WIKIPATHWAYS_20260510%WP3893%HOMO SAPIENS Development and heterogeneity of the ILC family IL6 IL1B AREG IL13 IL22 RORC IL7 HNF1A GFI1 RORA EOMES AHR IL33 TSLP BCL11B TOX IL12B IL12A IFNG IL23A IL5 GATA3 NFIL3 TBX21 IL9 IL4 ID2-1 IL25 TNF ZBTB16 IL17A IL18 IL15 CANNABINOID RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP3869%HOMO SAPIENS Cannabinoid receptor signaling CYP1A1 CYP2C9;CYP2C19 PRKAR1B PRKAR1A CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ADORA2A DAGLA CNR1 ADCY1 ADCY7 PRKAR2B AHR MAPK1 PRKACB-1 NAPEPLD DAGLB MAPK12 MAPK11 MAPK10 FAAH MAPK9 MAPK8 CNR2 MAPK13 MAPK3 PRKACA-1 MAPK14 COHESIN COMPLEX CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260510%WP5117%HOMO SAPIENS Cohesin complex Cornelia de Lange syndrome PPP2R1B PTPA NIPBL PPP2R1A PPP2R5B PPP2R5A PPP2R5D AURKB CDCA5 RAD21 PDS5B PDS5A HDAC8 ESCO1 ESCO2 WAPL PLK1 REC8 SGO1 MAU2 STAG3 STAG2 CDK1 PTTG1;PTTG2 PPP2CB;PPP2CA SMC1A SMC1B SMC3 SGO2 ESPL1 PPP2R5E PPP2R5C APC OMEGA 3 OMEGA 6 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260510%WP4723%HOMO SAPIENS Omega 3 omega 6 fatty acid synthesis ACOX3 ELOVL5 ACOX1 ACSL1 ELOVL2 PLA2G6 ACSL4 ACSL3 FADS2 FADS1 ACOT2;ACOT1 PLA2G4A PLA2G5 JMJD7-PLA2G4B;PLA2G4B FAMILIAL HYPERLIPIDEMIA TYPE 4%WIKIPATHWAYS_20260510%WP5111%HOMO SAPIENS Familial hyperlipidemia type 4 LRP1 APOA5 LPL LCAT APOA4 LIPC LDLR PDIA2 MTTP SEL1L LMF1 PLTP ACSS1 GPIHBP1 GCK GCKR FAS APOC2 DGAT2 APOA2 APOA1 CETP NOD LIKE RECEPTOR NLR SIGNALING%WIKIPATHWAYS_20260510%WP288%HOMO SAPIENS Nod like receptor NLR signaling MAPK8 ERBIN IKBKB CHUK IKBKG EPHB2 RELA CD40 MAP3K7 LIPID METABOLISM IN SENESCENT CELLS%WIKIPATHWAYS_20260510%WP5149%HOMO SAPIENS Lipid metabolism in senescent cells PLA2G3 TP53 PTGS2-2 PLA2G6 PLA2G12A SLCO2A1 PLA2G4F PLA2G12B PLA2G4D PLA2G4E PLA2G7 HRAS PLA2G1B PLA2G4A PLA2G2D ALOX5 PLA2G5 PLA2G10;LOC100652777 CDKN1A HUNGER AND SATIETY%WIKIPATHWAYS_20260510%WP5445%HOMO SAPIENS Hunger and satiety GCG AGRP LEP POMC PYY GHRL MC4R NPY TGFB SMAD SIGNALING%WIKIPATHWAYS_20260510%WP5382%HOMO SAPIENS TGFB Smad signaling TGFBR3 POSTN SMAD4 CCN2 TGFBR1-1 SPARC TGFBR2 WWTR1 SERPINE1 SMAD2;SMAD3 YWHAG LUNG PATHOLOGY OF COVID 19%WIKIPATHWAYS_20260510%WP5146%HOMO SAPIENS Lung pathology of COVID 19 CGAS CXCL10 MAVS IFIH1 IL6 CXCL11 TBK1 STING1 DDX58 IRF3 IL1B TLR7 TLR3 CXCL9 CCL13;CCL2 TLR8 TNF CSF2 IL18 NFKB1 OXIDATIVE STRESS RESPONSE%WIKIPATHWAYS_20260510%WP408%HOMO SAPIENS Oxidative stress response CYP1A1 HMOX1 GPX1 XDH TXNRD2 TXNRD1 TXN2 SP1 NOX1 CYBB SOD2 CAT JUNB GSR NFE2L2 MGST1 GSTT2B;GSTT2 FOS NFKB1 GCLC NQO1 SOD3 UGT1A1;UGT1A6 MAPK10 NOX4 MAOA NFIX NOX3 SOD1 NOX5 MAPK14 NEUROINFLAMMATION AND GLUTAMATERGIC SIGNALING%WIKIPATHWAYS_20260510%WP5083%HOMO SAPIENS Neuroinflammation and glutamatergic signaling GFAP SLC6A9 GRIK5 GRIK3 GRIK4 GRIK1 LTA LRRC8C TGFBR2 LRRC8D SLC17A6 SLC17A7 BCL2 LRRC8B LRRC8E IL13 PPP1CB PLCB1 SLC1A4 NFKB2 IL6ST MAPK1 GRIK2 TRAF5 NFKB1 SMAD2;SMAD3 TGFB2 IFNGR2 SMAD4 TGFB3 BDNF PLCB2 PRKCG IL13RA1 SHMT1 PRKCB PRKCA DLD NOS1 FGF2 SRR SHMT2 PSAT1 PHGDH PSPH SLC38A2 CFL1 IL10RB IL10RA IL12B IL12A SLC38A1 IL1R1 IL1A TNFRSF1A CALM1 SLC38A5 DISC1 PRKACA-1 PLCB3 GRIN2C GLUL GRIN3B GRIN3A CAMK2B LRRC8A CAMK2D TNFRSF1B CAMK2A IRS1 SLC1A3 IL6R ADCY3 ADCY1 SLC7A10 ADCY8 PDHA1 DLAT CAMK2G ARC GRIA1 GRIA2 GRIN2D GRM1 GRM5 GLS2 JAK1 CAMK4 STAT1 GRIN2B TNF GRIN1 GLS PPP1CC INSR STAT3 SLC2A1 TGFBR3 IL6 GRM2 GRM4 GOT1-1 GRM7 IGF1 IL1B GRM8 PPP1CA TGFBR1-1 AKT1 CAMKK1 IL4R CAMKK2 IFNGR1 FOS LIF GRIN2A SMAD7 CREB1 IFNG NGF SOCS3 PLCB4 GRIA3 STAT6 IL4 CNTF MAPK3 IL1R2 NSMF TGFB1 IL10 SLC1A1 SLC1A2 SLC1A6 SLC38A3 GRIA4 TRPM4 DAO ETHER LIPID BIOSYNTHESIS%WIKIPATHWAYS_20260510%WP5275%HOMO SAPIENS Ether lipid biosynthesis PEX19 PEX3 ARSA PEDS1-UBE2V1;PEDS1 GAL3ST1 LPCAT1 FAR1 PEX1 ALDH3A2 LPIN1 GNPAT PEX7 PEX5L PEX16 AGMO DGKQ DHRS7B CEPT1 AGPS FAR2 UGT8 ACAD10 LPIN2 LPIN3 AUTOPHAGY IN PANCREATIC DUCTAL ADENOCARCINOMA%WIKIPATHWAYS_20260510%WP5331%HOMO SAPIENS Autophagy in pancreatic ductal adenocarcinoma PRKN KRAS VMP1 SHOC2 TP53 HMGB1-1 MDM2-2 SQSTM1 PINK1 ATG7 AGER MITF TFE3 MAP1LC3B2;MAP1LC3B-1 TFEB STAT3 IPO8 NFE2L2 BECN1 NFKB1 PARTHANATOS CELL DEATH SIGNALING PATHWAY%WIKIPATHWAYS_20260510%WP5585%HOMO SAPIENS Parthanatos cell death signaling pathway MIF AIFM1 PARP1 EFFECT OF PROGERIN ON GENES INVOLVED IN PROGERIA%WIKIPATHWAYS_20260510%WP4320%HOMO SAPIENS Effect of progerin on genes involved in progeria HDAC2 CBX3-1 INPP5K HDAC1 MBD3 MTA2 H3-3A MTA1 E2F1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 TP53 MBD2 RBBP7 LEF1 SUV39H1 SREBF1 CHD4 RB1 MTA3 KDM1A CBX5 CBX1 CHD3 RBBP4 GABA RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP4159%HOMO SAPIENS GABA receptor signaling GABRQ GABRA2 GABBR2 GABRA1 GABBR1 GABRP GABRA6 GABRA5 GPHN GABRA4 GABRA3 AP2A1 AP2A2 AP2B1 SLC6A1 AP2S1 AP2M1 SLC32A1 GAD1 GAD2 SLC6A11 GABRG1 ALDH9A1 ABAT GABRB3 GABRB2 GABRB1 GABRG3;GABRG2 GABRE GABRD ULTRACONSERVED REGION 339 MODULATION OF TUMOR SUPPRESSOR MICRORNAS IN CANCER%WIKIPATHWAYS_20260510%WP4284%HOMO SAPIENS Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer TP53 CCNE2 GLYCEROLIPIDS AND GLYCEROPHOSPHOLIPIDS%WIKIPATHWAYS_20260510%WP4722%HOMO SAPIENS Glycerolipids and glycerophospholipids PEMT CDIPT CDS1 CRLS1 PCYT1A DGKZ AGPAT4 GPAT4 CHPT1 CHKB PISD PCYT2 PTDSS2 PTDSS1 GPAM ETNK1 PLA2G1B DGAT2 PLD1 PNPLA3 DGAT1 PNPLA2 FOXP3 IN COVID 19%WIKIPATHWAYS_20260510%WP5063%HOMO SAPIENS FOXP3 in COVID 19 IL2 IL7R IL6 IL2RB CD80 CD28 STAT5A IL2RG STAT5B IL6R IL2RA IL6ST CD86 STAT3 FOXP3 EBOLA VIRUS INFECTION IN HOST%WIKIPATHWAYS_20260510%WP4217%HOMO SAPIENS Ebola virus infection in host EP300 ITGAV RAB7A VPS39 ACTN4 CREBBP VAV2 RASA2 HAVCR2 NFKB2 PIK3CA MAPK1 NFKB1 ICAM2 ICAM3 ITGA5 HLA-DOA HLA-DOB KPNA1 VPS18 VPS33A TIMD4 CLEC4G TSG101 CLTCL1 VPS11 VPS16 CAV3 CAV2 BST2 CLEC6A HLA-DPB1-1 ASGR1 HLA-DPA1 C1QBP HLA-DQB2;HLA-DQB1 CLEC4M;CD209-2 FLNB FLNC TBK1 EPS15 IKBKE DAB2IP CTSV;CTSL TPCN2 DDX58 PRKRA VPS41 IRF3 RAB9A CLTC IRF7 CLTB CTSB ACTG1 CLTA FLNA SCIN NPC1-1 NEDD4 ACTN1 TOP1 IQGAP1 NPC2 ACTB-1 RFC1 ITGA2 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 PIK3CD PIK3CB IGF1R HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E ITGA1 CDC42 CAV1 GSN EGFR TIAM1 TYRO3 STAT1 HLA-DRA REL ITGA3 ITGA6 FOLR1 HLA-DMB RAC1 AKT1 MBL2-1 RHOC RHOB MFGE8 GAS6 EIF2AK2 PIK3R3 PIK3R2 RHOA PIK3R1 VPS4A PAK1 TLR4 ADAM17 RAB5A ITGB1 SOCS3 RELB RELA HLA-DMA EIF2S1 IL4 MERTK AXL MAPK3 TFAP2A ITGA4 ITGB3 CAMKK2 PATHWAY%WIKIPATHWAYS_20260510%WP4874%HOMO SAPIENS CAMKK2 pathway EP300 CXCL11 KEAP1 RASGRP1 SELL NFATC2 FAM20C CD28 CCR9 PCK2 NFE2L2 MAPK1 RAF1 CHRM3 KLF1 EPOR ABCA1 GCK ULK1 C1QTNF12 SMC1A MAP1LC3B2;MAP1LC3B-1 ATP1B2 CRTC2 HMOX1 NOS1 HFE IFI44L MID1 STIM1 SPINT1 HMBS S100A8 PFKFB2 PFKFB3 NEDD4L SREBF1 GATM CYB5R3 NLRP1 WFS1 ASNS TRPV4 SPIRE1 MS4A3 OASL ERMAP CPOX GALNT9 MAMDC2 ATP10D TBXT TSPAN33 WDR35 SLC25A21 AHSP TMEM176B IRGC RHAG HDAC4 CALM1 SLC38A5 ICAM1 GIT1 RPTOR CCND1 HK2 KDR ARHGEF7 FASN PLAC8 TSPAN8 TSC1 CTSE MAF CAMK4 CAMK1 RPS6 RPS6KB1 TNF MTOR SLC2A1 HK1 SLC2A4 SLCO3A1 SQSTM1 MAP1LC3A SIRT1 CDH1 RAC1 PARP1 CAMKK2 CREB1 PAK1 HIF1A ACACA RELA CDC25A AQP1 CCNE1 CCL5 MAPK3 FIS1 VCAM1 DNM1L IL15 MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY WITH INHIBITORS%WIKIPATHWAYS_20260510%WP4189%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway with inhibitors MVD HMGCR EXERCISE INDUCED CIRCADIAN REGULATION%WIKIPATHWAYS_20260510%WP410%HOMO SAPIENS Exercise induced circadian regulation CBX3-1 UGP2 HSPA8 NCKAP1 NR1D2 H2BC15;H2BC3;H2BC11;H2BC12 SUMO1 NCOA4 EIF4G2 GFRA1 CRY2 SF3A3 TUBB3;TUBB6 CRY1 DAZAP2 CLOCK BTG1 CEBPB AZIN1-2 TOB1 ARNTL HERPUD1 IDI1 PURA HLA-DMA UCP3 GSTM3 STBD1 SUMO3 ERC2 RBPMS GSTP1 ZFR PPP2CB;PPP2CA G0S2 QKI PER1 ETV6 CLDN5 PSMA4 VAPA PPP1R3C DNAJA1-1 KLF9 TAB2 PIGF MYF6 PER2 ECTODERM DIFFERENTIATION%WIKIPATHWAYS_20260510%WP2858%HOMO SAPIENS Ectoderm differentiation SOX2 FYN CTBP1 RGMA NLK CTNNB1 NF2 ROR2 PODXL TCF7L1 SMAD4 AHI1 ABCC4 PRKAG2 UBTF SNCA PGM1 MKS1 HMGB2 CAP2 PDE7A FOXA2 HDAC10 CELSR2 TSKU NARS2 POU2F2 ANKS1B KCNK10 GRAMD1B-1 MZF1 ASTN1 LY6E ARX GATA6 STC1 PIM1 ARHGAP15 ZBTB2 SOCS2 FHL2 ELOVL2 TRPM2 MYC ST8SIA4 NR2F2 HESX1 ZBTB7B GAS2L1 GREB1 CTNNA2 ZFHX4 SPRY2 PAN2 PLCXD3 PTPRB PPFIBP2 CCDC88C TLE5 CCDC130 NUMA1 TNFRSF11B LDB2 EDA2R WDR44 LHX1 PHF8 SIX6 RAB8B BCAS3 ELOVL4 TSC22D1 PAX3 BOC PAX6 CDON SORCS1 BAZ1A NLGN1 FOXL1 SMURF1 CLDN11 CTNND2 TOX3 ARHGAP10 PPARD KIFC3 STX16 BMPR1A RRBP1 JAKMIP1 HDAC6 IQCJ-SCHIP1;SCHIP1 KRT6B;KRT6C;KRT6A SERPINB6-2 CLVS1 WNT1 TTC14 C1GALT1 PTPN13 VAX2 RIT1 SGSM3 ZNF219 ZBTB16 TRIM33 MYORG BCOR TFAP2C FGFR2 MECP2 SDCBP MAFB DMD ARHGDIG SKIL FZD5 FZD4 PI4KA EDA GLB1 CCL13;CCL2 OGT-1 SHH NFATC1 FZD8 TFAP2A BMP4 JUP CDH8 GLI3 CDH6 PLXNA2 RIOK1 AND RIOK2 IN EGFR AND PI3K MEDIATED TUMORIGENESIS%WIKIPATHWAYS_20260510%WP3873%HOMO SAPIENS RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis PTEN TP53 FOXO3 AKT2 AKT3 EGFR MLST8 MAPKAP1 RICTOR AKT1 PIK3CA RPL11 MTOR RIOK2 RIOK1 IRON METABOLISM IN PLACENTA%WIKIPATHWAYS_20260510%WP2007%HOMO SAPIENS Iron metabolism in placenta TFRC SLC40A1 ACO1 MCOLN1 TF STEAP3 HEPHL1 TFR2 IREB2 SLC11A2 HAMP SLC25A46 PATHWAY%WIKIPATHWAYS_20260510%WP5521%HOMO SAPIENS SLC25A46 pathway APOOL MMGT1 IMMT EMC10 MICOS13 MICOS10 APOO CHCHD3 CHCHD6 EMC1 EMC2 EMC3 EMC4 EMC6 EMC7 EMC8 SLC25A46 OPA1 MFN1 MFN2 DNM1L NRF2 PATHWAY%WIKIPATHWAYS_20260510%WP2884%HOMO SAPIENS NRF2 pathway SLC6A9 SLC39A12 SLC39A14 BLVRB KEAP1 SLC5A11 SLC5A12 SLC5A10 CBR3 TGFBR2 NFE2L2 SLC6A1 SLC2A5 TGFB2 SLC6A11 ABCC3 ABCC4 ABCC2 CBR1-1 DNAJB1 SLC7A11 HMOX1 TXNRD3 TXNRD1 SLC6A8 SLC39A2 PDGFB TXN SLC39A1 SLC39A4 SLC39A3 NQO1 UGT1A1;UGT1A6 ALDH3A1 GSTM4 GSTA3;GSTA5;GSTA1;GSTA2 CES3 GSTM3 GSTP1 FGF13 HSP90AB1 HGF MGST3 MGST2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 AGER EGR1 GSTA4 GSR GSTT2B;GSTT2 GSTM1;GSTM2-1 PRDX1 GSTA3;GSTA1 GCLC GCLM GGT1 EPHA2 PPARD PTGR1-1 SLC2A1 PGD MAFG MAFF RXRA SLC2A4 G6PD SLC5A1-1 SQSTM1 SLC2A2 FTL-1 HSPA1A;HSPA1B NRG1 SLC39A9 FTH1 SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC6A19 HSP90AA1 HBEGF SLC6A18 SLC6A17 SLC6A16 TGFA SLC6A15 SLC6A14 SLC6A13 SLC6A6 SLC5A6 SLC5A7 SLC5A8 SOD3 SLC5A9 EPHA3 SLC6A20 SLC5A2 CES5A CES2 SLC5A3 CES1 SLC5A4 SLC5A5 PRDX6 SLC2A9 SLC6A5 SLC6A7 SERPINA1 SRXN1 SLC2A6 SLC6A2 SLC2A7 SLC6A4 SLC6A3 SLC2A8 ME1 TGFB1 SLC2A11 SLC2A10 ABCC5 SLC2A13 SLC2A12 SLC39A11 CYP2A13;CYP2A6;CYP2A7-1 SLC39A10 SLC39A13 HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP313%HOMO SAPIENS Hepatocyte growth factor receptor signaling HGF GRB2 PTEN ITGA1 PTGS2-2 MAP4K1 RASA1 RAPGEF1 CRKL ELK1 PTK2B GAB1 DOCK1 HRAS JUN PIK3CA CRK MAPK1 RAF1 FOS PXN SOS1 PAK1 MET ITGB1 SRC RAP1A PTPN11 RAP1B MAPK8 MAP2K2;MAP2K1 MAPK3 STAT3 PTK2 CELL LINEAGE MAP FOR NEURONAL DIFFERENTIATION%WIKIPATHWAYS_20260510%WP5417%HOMO SAPIENS Cell lineage map for neuronal differentiation SOX2 GFAP SLC6A9 NR4A2 CSPG4 HNF4A RIMS2 ESRRB PPFIA1 SLC17A6 HOMER3 GPHN SLC17A7 BSN RBFOX3 MSX2 DPPA3 FBXO15 CASK ZFP42 TBR1 NOTCH1 TPH1 CHAT POU5F1;POU5F1B LIN7A FUT4 MAP2 EVX1 DLG2 DLG3 FEV CD24 NES NODAL PCLO ERC1 SLC6A1 SLC18A3 FOXD3 DLG1 DPPA2 DCX NANOG;NANOGP8 GLRA1 GAD1 GLRA2 GAD2 GLRA3 CACNG2 HES3 KCNJ6 MBP CD34 MOG GLRB RIMBP2 PECAM1 TWIST2 FGF4 HOMER2 HTR1A FABP7 HES1 SHANK1 TBXT TPM1 TH FOXA2 GATA6 GLUL SLC1A3 ROBO1 AP2A1 NEFL AP2A2 NEFM LHX1 ACHE ERAS PAX3 PAX6 KLF4 TNC SNAP25 UNC13A NLGN1 CLDN11 SYP KRT15 LEF1 HES5 SOX17 HOMER1 NGFR GRIN2B GRIN1 GLS DLG4 SHANK3 MIXL1 GABBR2 GABBR1 GATA4 ITGA6 CDH1 DLL1 ALDH1L1 SOX9 TUBB3;TUBB6 CDH2 OLIG2 SOX10 ITGB1 SLC6A5 AQP4 ADRA2C SLC6A2 HTR5A ADRA2B SLC6A4 ADRA2A SLC6A3 BMP4 MSX1 SNAI1 CNP SLC1A2 SNAI2 LMX1B DISORDERS IN KETONE BODY SYNTHESIS%WIKIPATHWAYS_20260510%WP5175%HOMO SAPIENS Disorders in ketone body synthesis ACAT1 HMGCL BDH1 OXCT1-1 HMGCS2 MRNA VACCINE ACTIVATION OF DENDRITIC CELL AND INDUCTION OF IFN 1%WIKIPATHWAYS_20260510%WP5187%HOMO SAPIENS mRNA vaccine activation of dendritic cell and induction of IFN 1 MAVS IFIH1 TLR8 DDX58 IRF3 IRF7 TLR7 TNFRSF11A MR1 TLR3 BIOGENIC AMINE SYNTHESIS%WIKIPATHWAYS_20260510%WP550%HOMO SAPIENS Biogenic amine synthesis ACHE GAD1 GAD2 ASMT DBH AANAT DDC PAH PNMT TPH1 TH MAOA CHAT COMT HDC GPR40 ROLE IN INSULIN SECRETION%WIKIPATHWAYS_20260510%WP3958%HOMO SAPIENS GPR40 role in insulin secretion PLCE1 PLCB3 PLCD3 ITPR3 PLCD1 PLCL1 PLCH1 PLCB1 FFAR1 PLCB2 PLCG2 PLCG1 PKD1 PLCZ1 GNA11 GLYCOSYLPHOSPHATIDYL INOSITOL ANCHOR PATHWAY%WIKIPATHWAYS_20260510%WP5505%HOMO SAPIENS Glycosylphosphatidyl inositol anchor pathway PIGB PIGA PIGK PIGM PIGL MPPE1 PIGG PIGH PGAP3 PIGS PIGU PIGT PGAP1 PIGO PIGW PGAP2 PIGN GPAA1 PIGF PIGQ PIGP PIGV PIGX-1 PIGC DPM2 FAMILIAL HYPERLIPIDEMIA TYPE 5%WIKIPATHWAYS_20260510%WP5112%HOMO SAPIENS Familial hyperlipidemia type 5 LRP1 APOA5 LPL LCAT APOA4 LIPC LDLR SEL1L LMF1 PLTP GPIHBP1 APOC2 APOA2 APOA1 CETP LNCRNA IN CANONICAL WNT SIGNALING AND COLORECTAL CANCER%WIKIPATHWAYS_20260510%WP4258%HOMO SAPIENS lncRNA in canonical Wnt signaling and colorectal cancer FOSL1 FRAT2 APC2 CTBP1 CCND1 NLK TCF7 CTNNB1 MYC DVL1 DVL2 DVL3 TCF7L2 CDK6 RYK-1 AXIN1 EZH2 ROR1 TPTEP2-CSNK1E;CSNK1E ROR2 JUN AXIN2 TCF7L1 SERPINF1 LEF1 LRP5 MAP3K7 LRP6 WNT1 SOX17 PLAU DKK4 CER1 HNRNPU CTNNBIP1 CSNK1A1 CSNK2A2 DKK2 SFRP2 FZD6 SFRP5 CSNK2B MACROH2A2 PORCN APC CHD8 RUVBL1 SOST KREMEN1 SENP2 CXXC4 NKD1 CDK8 NKD2 WIF1 NOTUM GSK3B WNT2B FZD10 WNT5B WNT16 SFRP4 WNT6 WNT11 WNT2 WNT3 WNT10B WNT10A FZD3 FZD2 FZD5 CTBP2 ATF3 WNT3A WNT7B FZD7 FZD9 HNRNPK WNT7A FZD8 FZD1 CCND3 WNT5A CSNK2A1;CSNK2A3 TFAP2A DKK1 SFRP1 CCND2 WNT4 PLATELET MEDIATED INTERACTIONS WITH VASCULAR AND CIRCULATING CELLS%WIKIPATHWAYS_20260510%WP4462%HOMO SAPIENS Platelet mediated interactions with vascular and circulating cells SELPLG TGFB2 SELP CD40LG TGFB3 SELE ICAM1 TLR4 TLR2 IL1B TLR7 CD40 CCL13;CCL2 CCL5 TGFB1 PF4;PF4V1-1 VCAM1 PURINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260510%WP4224%HOMO SAPIENS Purine metabolism and related disorders AOX1 XDH ATIC ADSL MOCOS GRM5 ADA AMPD1 PFAS APRT TPMT DGUOK MAT2A IMPDH1 PPAT ADSS2 GART HPRT1 RRM2B ITPA PRPS1 PAICS PNP-1 SEROTONIN RECEPTOR 2 AND ELK SRF GATA4 SIGNALING%WIKIPATHWAYS_20260510%WP732%HOMO SAPIENS Serotonin receptor 2 and ELK SRF GATA4 signaling KRAS NRAS GNAQ RASGRP1 GATA4 ITPR1 HTR2B SRF RASGRF1 ELK1 HTR2A ELK4 MAP2K2;MAP2K1 HRAS MAPK3 MAPKAPK2 MAPK1 RAF1 PARKINSON 39 S DISEASE PATHWAY%WIKIPATHWAYS_20260510%WP2371%HOMO SAPIENS Parkinson 39 s disease pathway CASP6 CCNE2 CASP2 PARK7 PINK1 UCHL1 CASP9 CASP3 UBA7 LRRK2 UBE2L6 ATXN2 GPR37 SEPTIN5 UBE2G1 APAF1 UBE2G2 SNCAIP MAPK12 EPRS1 SYT11 MAPK11 UBA1 PRKN CASP7 CYCS-1 DDC TH UBE2J1 MAPK13 CCNE1 SLC6A3 SNCA HTRA2 UBE2J2 UBB;UBC MAPK14 INTEGRATED CANCER PATHWAY%WIKIPATHWAYS_20260510%WP1971%HOMO SAPIENS Integrated cancer pathway CHEK1 POU2F1 BLM MSH2 PTEN CDC25B NOXA1 CDKN2B BCL2 MYC BRCA1 CASP9 MMP1 CDK4 CASP3 AKT1 MAP3K5 BACH1 MRE11 BBC3 SMAD2;SMAD3 MSH6 CASP8 RAD50 PLK1 E2F1 TP53 ATF1 BAD CDK2 MDM2-2 BARD1 JAK1 CDK1 ATR BAX CDKN1B STAT1 CDC25A RB1 ATM CHEK2 CDKN1A OSTEOCLAST SIGNALING%WIKIPATHWAYS_20260510%WP12%HOMO SAPIENS Osteoclast signaling PDGFB AIMP2 IFNAR1 ATP6V1G1 GPR68 SLC9A1 TRPV5 ACP5 IFNB1-4 SPP1 CTSK MAPK8 TNFRSF11B TNFRSF11A ITGB3 TNFSF11 ONCOSTATIN M SIGNALING%WIKIPATHWAYS_20260510%WP2374%HOMO SAPIENS Oncostatin M signaling IRS1 PTK2B JAK2 HRAS RICTOR EGR1 NFKBIA VEGFA IL6ST MAPK1 RAF1 NFKB1 CASP7 SOS1 SRC CDK2 JAK1 STAT5B JAK3 STAT1 RPS6 PRKCH PRKCB PRKCE PRKCD PRKCA STAT3 OSM MTOR KRAS GRB2 SHC1-1 OSMR CASP3 AKT1 JUNB LIFR PIAS3 FOS TYK2 PXN PIK3R1 CREB1 CEBPB HIF1A SOCS3 RELA PTPN11 MAPK9 CDKN1B MAPK8 MAP2K2;MAP2K1 MAPK3 JUND MAPK14 BENZENE METABOLISM%WIKIPATHWAYS_20260510%WP3891%HOMO SAPIENS Benzene metabolism CYP2E1 NQO1 DHDH MPO EPHX1 GSTM1;GSTM2-1 HFE EFFECT ON HEPCIDIN PRODUCTION%WIKIPATHWAYS_20260510%WP3924%HOMO SAPIENS Hfe effect on hepcidin production SMAD7 BMP6 TMPRSS6 HJV ID1 HFE HAMP MECHANOREGULATION AND PATHOLOGY OF YAP TAZ VIA HIPPO AND NON HIPPO MECHANISMS%WIKIPATHWAYS_20260510%WP4534%HOMO SAPIENS Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms ITGB7 TEAD4 CTNNA1 SAV1 BUB1B-PAK6;PAK6 ITGB2 MAP4K1 CTNNB1 NF2 ACTG1 MST1 ACTC1;ACTG2 CDH1 ITGB6 ITGB4 LIMD1 MAP4K2 PAK1 PAK3 MAP4K3 PAK2 MAP4K4 PAK5 PAK4 ACTA2 MAPK10 ITGB1 SRC STK3 YAP1-1 MAPK9 MAPK8 TEAD1 LATS1 TEAD2 ACTA1 TEAD3 SGMS1 ITGB5 ITGB8 WWTR1 ACTB-1 ITGB3 YWHAQ MAP4K5 NUCLEOTIDE METABOLISM%WIKIPATHWAYS_20260510%WP404%HOMO SAPIENS Nucleotide metabolism RRM2-1 SRM POLD1 PRPS2 ADSL OAZ1 POLB RRM1 IMPDH1 MTHFD2 ADSS2 SAT1 HPRT1 RRM2B POLA1 POLG NME2 PRPS1 DHFR2;DHFR EV RELEASE FROM CARDIAC CELLS AND THEIR FUNCTIONAL EFFECTS%WIKIPATHWAYS_20260510%WP3297%HOMO SAPIENS EV release from cardiac cells and their functional effects MYB CXCL12 ERBB4 PRL RGS16 KLF2 NEOVASCULARIZATION PROCESSES%WIKIPATHWAYS_20260510%WP4331%HOMO SAPIENS Neovascularization processes MMP9 REL FLT4 CXCL12 NOTCH1 KDR TGFBR1-1 DLL4 AKT1 JAG1 NFKB2 MAPK1 NFKB1 SMAD2;SMAD3 KIT PDGFB TGFB2 ACVRL1 TGFB3 KITLG HIF1A RELB RELA EPHB2 EPHB4 MAPK9 CXCR4 MAPK8 MAPK3 SMAD1 NOTCH3 TGFB1 SMAD9 NOTCH4 SMAD5 ANGPT1 DYRK1A INVOLVEMENT REGARDING CELL PROLIFERATION IN BRAIN DEVELOPMENT%WIKIPATHWAYS_20260510%WP5180%HOMO SAPIENS DYRK1A involvement regarding cell proliferation in brain development NEUROG2 H3-3A DCAF7 DYRK1A RPTOR DEPTOR CCND1 E2F4-1 MLST8 NOTCH1 CDK6 SPRY2 EIF2B5 CDK4 TSC2 TSC1 FOXO1-1 AKT1S1 HIP1 TP53 HES5 RBL2 LATS2 RBL1 MAPT CSNK1A1 TFDP1 TFDP2 MTOR E2F5 FGF2 GSK3B REST SIRT1 CASP9 DLL1 APP CASP3 DNM1 CRY2 HES1 CREB1 BACE1 PSEN1 DNER LIN54 GMNN LIN52 PSENEN AMPH RAD54L2 CDKN1B LIN37 NFATC1 LIN9 APH1A NCSTN TFAP4 SMARCB1 GLI1 RBBP4 APOPTOSIS%WIKIPATHWAYS_20260510%WP254%HOMO SAPIENS Apoptosis TRAF1 LTA IGF1R IRF6 CDKN2A BCL2 TNFRSF1B MYC BIRC2 TRADD NFKBIB PMAIP1 BNIP3L IKBKB NFKBIA IRF1 BIRC5 JUN MAP3K1 CHUK BIRC3 IKBKG TRAF2 MCL1 APAF1 FASLG NFKB1 BBC3 CASP7 CASP8 BCL2L11 RIPK1 FADD TP53 BID BCL2L1 IGF2 MDM2-2 CASP1 TNF TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A GZMH;GZMB-1 TRAF3 NFKBIE CASP6 IRF3 IRF7 CASP2 IGF1 DFFB DFFA CASP10 MAP2K4 CASP9 CASP3 AKT1 BOK TNFSF10 PIK3R1 XIAP IRF4 CYCS-1 TNFRSF1A BAK1 MAPK10 BAD RELA IRF5 DIABLO-1 BAX TP63 FAS HRK PRF1 HELLS SCAF11 IRF2 TNFRSF25 TNFRSF21 TP73 CRADD CASP5;CASP4 CFLAR BCL2L2 MIRNA REGULATION OF PROSTATE CANCER SIGNALING%WIKIPATHWAYS_20260510%WP3981%HOMO SAPIENS miRNA regulation of prostate cancer signaling KRAS GRB2 KLK3;KLK2 CCND1 BCL2 TCF7 CTNNB1 GSK3B AKT3 CASP9 CREBBP PDGFRB NFKBIA PIK3CA FOXO1-1 MAPK1 IKBKG RAF1 NFKB1 SOS1 TP53 BAD MDM2-2 CREB3L1 PDGFA CDKN1B MAP2K2;MAP2K1 MTOR AR CDKN1A NOVEL INTRACELLULAR COMPONENTS OF RIG I LIKE RECEPTOR PATHWAY%WIKIPATHWAYS_20260510%WP3865%HOMO SAPIENS Novel intracellular components of RIG I like receptor pathway AZI2 CXCL10 DDX17 SIKE1 RNF125 CXCL12 IFNE IFNK TKFC DDX3X-1 CYLD SNW1 PIN1 TBKBP1 TRADD NFKBIB DHX58 IKBKB TRIM25 NFKBIA MAP3K1 CHUK TRAF6 IKBKG TRAF2 NFKB1 MAPK12 MAPK11 TANK CASP8 RIPK1 FADD IFNB1-4 MAP3K7 NLRX1 TNF MAVS IFIH1 TBK1 STING1 IKBKE TRAF3 DDX58 ISG15 IRF3 IRF7 CXCL8 CASP10 ATG5 ATG12-1 IFNG MAPK10 RELA MAPK9 MAPK8 MAPK13 MAPK14 OTUD5 TYPE II INTERFERON SIGNALING%WIKIPATHWAYS_20260510%WP619%HOMO SAPIENS Type II interferon signaling CXCL10 ICAM1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E ISG15 IL1B CIITA CXCL9 GBP2;GBP3;GBP1 CYBB REG1B;REG1A TAP1 IFIT2 PSMB9 JAK2 IRF1 NOS2 EIF2AK2 IFNGR1 OAS1 IRF8 IFNGR2 IFNG IRF9 IRF4 IFNB1-4 STAT2 SOCS3 JAK1 PTPN11 STAT1 SPI1 SOCS1 PRKCD IRF2 BIOSYNTHESIS AND REGENERATION OF TETRAHYDROBIOPTERIN AND CATABOLISM OF PHENYLALANINE%WIKIPATHWAYS_20260510%WP4156%HOMO SAPIENS Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine ASMT DBH AANAT PAH PNMT MAOB TH GCH1 MAOA DNAJC12 PTS COMT QDPR SPR DHFR2;DHFR GLIOBLASTOMA SIGNALING%WIKIPATHWAYS_20260510%WP2261%HOMO SAPIENS Glioblastoma signaling EP300 PTEN PIK3CD PIK3CB PIK3CG IGF1R CCND1 CDKN2A FOXO4 MDM4 AKT2 AKT3 BRCA1 IRS1 CDK6 SPRY2 PIK3C2G CDK4 PIK3C2A HRAS PDGFRB PDGFRA ERRFI1 PIK3C2B TSC2 TSC1 PIK3CA FOXO1-1 ERBB2 MAPK1 RAF1 MAP2K6 MET TP53 MAP2K3 SRC FOXO3 CDK2 MDM2-2 MAP2K5 EGFR PRKCG PRKCH PRKCB PRKCD PRKCA KRAS GRB2 PRKCQ FGFR2 FGFR1 CDKN2B CDKN2C ARAF MAP2K4 PDPK1 PRKCZ GAB1 AKT1 PRKCI CBL PIK3R2 ERBB3 BRCA2 MSH6 PIK3R1 NRAS MAP2K7 E2F1 NF1 CDKN1B MAP2K2;MAP2K1 CCNE1 PLCG2 PLCG1 RB1 MAPK3 ATM BRAF CCND2 CDKN1A SOMATROPH AXIS GH AND ITS RELATIONSHIP TO DIETARY RESTRICTION AND AGING%WIKIPATHWAYS_20260510%WP4186%HOMO SAPIENS Somatroph axis GH and its relationship to dietary restriction and aging PTEN AKT1 IGF1R FOXO1-1 MTOR SIRT1 INHIBITION OF GNAQ REGULATED SIGNALING IN UVEAL MELANOMA%WIKIPATHWAYS_20260510%WP5490%HOMO SAPIENS Inhibition of GNAQ regulated signaling in uveal melanoma PLCB3 PIK3CD PIK3CB TEAD4 AKT2 AKT3 PLCB1 ROCK1 AKT1 TSC2 TSC1 PIK3CA MAPK1 PIK3R3 PIK3R2 RHOA PIK3R1 GNAQ TRIO YAP1-1 PLCB4 MOB1A;MOB1B PKN3 TEAD1 LATS1 PLCB2 TEAD2 PKN2 TEAD3 LATS2 PKN1 MTOR PTK2 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260510%WP47%HOMO SAPIENS Hedgehog signaling PTCH2 ARNTL PTCH1 GRK2 KIF7 DHH SHH SMO SIN3A STK36 SAP18 GLI1 GLI3 IHH GLI2 OSTEOPONTIN SIGNALING%WIKIPATHWAYS_20260510%WP1434%HOMO SAPIENS Osteopontin signaling MMP9 ITGAV RELA SPP1 MAP2K2;MAP2K1 IKBKB PLAU MAPK3 CHUK MAPK1 ITGB3 MAP3K14 NFKB1 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES AUTOPHAGY%WIKIPATHWAYS_20260510%WP4863%HOMO SAPIENS Host pathogen interaction of human coronaviruses autophagy ULK2 ATG13 MAP1LC3A ULK1 RB1CC1 ATG5 ATG3 PIK3C3 PIK3R4 ATG7 ATG10 WIPI1 ZFYVE1 ATG16L2 BECN1 MTOR ATG12-1 ATG16L1 ATG4A CYTOSOLIC DNA SENSING PATHWAY%WIKIPATHWAYS_20260510%WP4655%HOMO SAPIENS Cytosolic DNA sensing pathway CXCL10 RNF125 RIPK3 CYLD TRADD NFKBIB POLR3GL IKBKB TRIM25 NFKBIA CHUK POLR3A POLR3B POLR3C IKBKG ZBP1 POLR3D AIM2 TREX1 POLR3E NFKB1 POLR3F POLR3G POLR3K CASP8 RIPK1 FADD IFNB1-4 ADAR CASP1 NLRX1 IL18 CGAS MAVS IL6 TBK1 STING1 IKBKE PYCARD DDX58 ISG15 IRF3 IRF7 IL1B CASP10 ATG5 IL33 ATG12-1 POLR3H POLR1C POLR1D RELA CCL4L2;CCL4L1;CCL4 CCL5 POLR2E POLR2F POLR2H POLR2L 6Q16 COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5400%HOMO SAPIENS 6q16 copy number variation SIM1 LEP POMC ARNT GHRL BDNF MC4R NPY AGRP NTRK2 INSR INS;INS-IGF2 GHSR LEPR CHOLESTEROL SYNTHESIS DISORDERS%WIKIPATHWAYS_20260510%WP5193%HOMO SAPIENS Cholesterol synthesis disorders LSS HSD3B1;HSD3B2 EBP IDI1 CYP51A1 FDPS MVK SC5D DHCR7 MSMO1 DHCR24 PMVK MVD SQLE FDFT1 LBR HMGCR HMGCS1-1 CELL INTERACTIONS IN PANCREATIC CANCER MICROENVIRONMENT%WIKIPATHWAYS_20260510%WP5284%HOMO SAPIENS Cell interactions in pancreatic cancer microenvironment CXCL10 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CXCL12 CTLA4 CD80 KDR CSF2 VEGFA CSF1 ITGB6 CCR2 LAG3 CSF2RA FASLG IFITM3;IFITM2;IFITM1 BAG3 CSF1R NRP1 CCL13;CCL2 CXCR4 CCR5 CCL5 FAS CXCR3 HLA-DRA TGFB1 CD86 CHOLESTEROL BIOSYNTHESIS PATHWAY IN HEPATOCYTES%WIKIPATHWAYS_20260510%WP5329%HOMO SAPIENS Cholesterol biosynthesis pathway in hepatocytes CH25H CYP7A1 ELOVL5 ACSL1 NR1H2 ELOVL2 CYP51A1 ELOVL3 ACSL3 FADS2 MSMO1 SCD SREBF1 TM7SF2 NSDHL ACOT2;ACOT1 LBR MYLIP CYP46A1 HMGCS1-1 ELOVL4 LSS PLPP6 ABCG1 HSD17B7 EBP ABCA1 IDI1 FDPS MVK SC5D GGPS1 IDI2 ACAT2 PMVK DHCR24 MVD FDFT1 HMGCS2 CYP27A1 HMGCR NR1H3 TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20260510%WP465%HOMO SAPIENS Tryptophan metabolism CYP1A1 AOX1 GOT2-1 TPH1 CAT AHR TPH2 HAAO ACMSD IL4I1 TDO2 INMT GCDH AFMID AOC1 KYAT3 ECHS1 ASMT AADAT KYAT1 IDO2 IDO1 AANAT ALDH8A1 DDC KYNU MAOA ACAT1 STAT1 KMO HADH ALDH2 DLD T CELL MODULATION AND DESMOPLASIA IN PANCREATIC CANCER%WIKIPATHWAYS_20260510%WP5078%HOMO SAPIENS T cell modulation and desmoplasia in pancreatic cancer VEGFC ARG1 CD274 CXCL12 PDCD1LG2 CTLA4 LGALS9C;LGALS9;LGALS9B HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CD28 IL13 PDCD1 VEGFD HAVCR2 VEGFA FASLG ICOS CCL17 TGFB2 CD40LG TGFB3 CCL22 LGALS1 TNFRSF4 TNFSF9 PVR VSIR B2M CD226 VTCN1 TIGIT CD276 TNFRSF9 FAP IL6 CD80 TNFSF4 NT5E LGALS3 PDGFB VDR CD40 IDO1 PDGFA PDGFD PDGFC SHH VEGFB CXCR4 IL4 FAS PGF IL10 TGFB1 CD86 ENTPD1 FLUOROACETIC ACID TOXICITY%WIKIPATHWAYS_20260510%WP4966%HOMO SAPIENS Fluoroacetic acid toxicity ALDH3A2 ACO2 ALDH9A1 ACSS2 CS ALDH2 COPPER METABOLISM%WIKIPATHWAYS_20260510%WP5189%HOMO SAPIENS Copper metabolism ATP7B ATP7A SLC31A1 SLC11A2 GLUCURONIDATION%WIKIPATHWAYS_20260510%WP698%HOMO SAPIENS Glucuronidation HK1 UGP2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 UGT1A1;UGT1A6 PGM1 UGDH PGM3 UGT2A1 PGM2 PGM5 FLAVAN 3 OL METABOLIC PATHWAY%WIKIPATHWAYS_20260510%WP4238%HOMO SAPIENS Flavan 3 ol metabolic pathway COMT MIR 222 IN EXERCISE INDUCED CARDIAC GROWTH%WIKIPATHWAYS_20260510%WP3938%HOMO SAPIENS miR 222 in exercise induced cardiac growth CDKN1B HMBOX1 HIPK1 HIPK2 DISORDERS OF FRUCTOSE METABOLISM%WIKIPATHWAYS_20260510%WP5178%HOMO SAPIENS Disorders of fructose metabolism HK1 SORD ALDOB PGM1 GLYCTK SLC5A1-1 SLC2A2 PFKL GPI TPI1 G6PC1 FBP1 KHK ALDH1A1 INTERACTIONS OF NATURAL KILLER CELLS IN PANCREATIC CANCER%WIKIPATHWAYS_20260510%WP5092%HOMO SAPIENS Interactions of natural killer cells in pancreatic cancer ADAM10 FCGR3A;FCGR3B GZMH;GZMB-1 IFNG NCR3LG1-1 KLRC4-KLRK1;KLRK1 ADAM17 CCL3L1;CCL3L3;CCL3;CCL18 MYC CCL13;CCL2 PVR NCR1-1 CD226 GATA2 CCL4L2;CCL4L1;CCL4 TIGIT CCL5 TNF CSF2 PRF1 FOXO1-1 BMI1 CD96 CCL1 13Q12 OR CRYL1 COPY NUMBER VARIATION %WIKIPATHWAYS_20260510%WP5405%HOMO SAPIENS 13q12 or CRYL1 copy number variation CRYL1 COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260510%WP558%HOMO SAPIENS Complement and coagulation cascades BDKRB1 F12 F13B KLKB1 F2 SERPINE1 PLAUR PROS1 CLU C3AR1 LOC110384692;C4A;C4B_2;C4B SERPING1 MASP2 MASP1 PLAU CFB CFD CFI C5AR1 C2 C6 PROC FGB F9 C7 C9 F10 SERPINA5 THBD F7 VWF PLG SERPINF2 F5 CFH-3 CLTC F8 CPB2 SERPINC1 TFPI LMAN1 C8G SERPIND1 PLAT CR2 F2R C1QB C1S C1R CD55 CR1L;CR1 SERPINA1 C3-1 C1QC KNG1 F3 HORMONAL CONTROL OF PUBERTAL GROWTH SPURT%WIKIPATHWAYS_20260510%WP4194%HOMO SAPIENS Hormonal control of pubertal growth spurt GHRH IGF1 GNRH1 SST RESISTIN AS A REGULATOR OF INFLAMMATION%WIKIPATHWAYS_20260510%WP4481%HOMO SAPIENS Resistin as a regulator of inflammation IL6 PLCB3 PIK3CD PIK3CB PIK3CG ITPR1 AKT2 CXCL8 AKT3 PLCB1 IKBKB AKT1 NFKBIA CHUK PIK3CA MAPK1 IKBKG IL12B NFKB1 IL12A PLCE1 PLCD4 PLCB4 RELA PLCD3 RETN PLCD1 PLCB2 PLCG2 TNF PLCG1 MAPK3 MAPK14 MAPK SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260510%WP5530%HOMO SAPIENS MAPK signaling and ARTD family members MAP3K9 ARAF MAP3K21 MAP2K4 MAP3K1 MAP3K11 MAP3K5 MAP3K8 MAPK1 PARP1 RAF1 MAPK12 MAP2K6 MAPK11 MAP2K7 TNKS DUSP1 MAP2K3 MAPK10 MAP3K10 MAPK9 MAP3K7 MAPK8 MAP2K2;MAP2K1 MAPK13 ATF4 MAPK3 PARP14 MAP3K12 BRAF MAPK14 ENDOTHELIN PATHWAYS%WIKIPATHWAYS_20260510%WP2197%HOMO SAPIENS Endothelin pathways CALCA CALCRL RAMP1 MYLK ADRB1 ECE1 CNN1 PLCB1 NPY1R RIIAD1 EDN1 GNAI1 MAPK1 MYL1 GNG13 RAF1 PTGIR GNB5 CAD EDNRA CALM1 GNA15 EDNRB NPY MAP2K2;MAP2K1 ATP2A2 ADCY10 ADRA1A PRKCA NOS3 GNAS-1 TYPE II DIABETES MELLITUS%WIKIPATHWAYS_20260510%WP1584%HOMO SAPIENS Type II diabetes mellitus GK SLC2A4 CACNA1A PHKA2 SLC2A2 IRS1 PRKCZ MAPK8 SURF1 KCNJ11 MAFA IKBKB TNF SOCS4 INSR PIK3R5 INS;INS-IGF2 MAPK1 MTOR PDX1 ADIPOQ NICOTINE EFFECT ON CHROMAFFIN CELLS%WIKIPATHWAYS_20260510%WP1603%HOMO SAPIENS Nicotine effect on chromaffin cells CHRNB4 CACNA1G CHRNA3 CACNA1C GLYOXYLATE METABOLISM%WIKIPATHWAYS_20260510%WP5166%HOMO SAPIENS Glyoxylate metabolism LDHA SLC26A1 PXMP2 AGXT GRHPR HAO1 ALDH4A1 GOT2-1 HOGA1 PRODH2 DAO NUCLEOTIDE GPCRS%WIKIPATHWAYS_20260510%WP80%HOMO SAPIENS Nucleotide GPCRs P2RY2 ADORA3 P2RY1 ADORA2A LTB4R ADORA1 LPAR4 LPAR6 P2RY6 P2RY4 ADORA2B PHOTODYNAMIC THERAPY INDUCED NFE2L2 NRF2 SURVIVAL SIGNALING%WIKIPATHWAYS_20260510%WP3612%HOMO SAPIENS Photodynamic therapy induced NFE2L2 NRF2 survival signaling MAPK11 HMOX1 GCLM NQO2 NQO1 ABCC6 KEAP1 EPHX1 CES1 ABCG2 ABCC3 ABCC4 SRXN1 GSTP1 MAPK8 ABCC2 MAPK13 JUN NFE2L2 MAPK14 FOS MAPK12 GCLC T CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP69%HOMO SAPIENS T cell receptor signaling ITK FYN NFATC2 CD8A ATF2 MAP4K1 VAV1 CD28 PTK2B HRAS IKBKB NFKBIA GRAP2 WAS JUN CHUK MAP3K8 TRAF6 CDC42 ZAP70 MAPK1 IKBKG LCP2 RAF1 CARD11 BCL10 MAP3K14 MALT1 NFKB1 ICOS SOS1 MAP3K7 DBNL GAB2 PRKCD REL GRB2 PRKCQ SHC1-1 ITPR1 VAV3 CBLB CRKL NCK1 PDPK1 CD3G AKT1 CD3E CD3D CRK FOS CBL PIK3R2 PIK3R1 CREB1 LCK PAK1 PSTPIP1 RIPK2 SKAP1 SH2B3 FYB1 RELA PTPN11 MAPK9 NFATC1 MAPK8 MAP2K2;MAP2K1 CD4 PLCG1 MAPK3 CD247 LAT MAPK14 RALA DOWNSTREAM REGULATED GENES%WIKIPATHWAYS_20260510%WP2290%HOMO SAPIENS RalA downstream regulated genes KRAS NRAS RAC1 HRAS RAC3 RALA-1 EXOC2 CDC42 YBX3 RALBP1-1 EXOC8 CANONICAL NF KB PATHWAY%WIKIPATHWAYS_20260510%WP4562%HOMO SAPIENS Canonical NF kB pathway REL IKBKB NFKBIA NFKBIE CHUK IKBKG RELA NFKB1 ATM SIGNALING IN DEVELOPMENT AND DISEASE %WIKIPATHWAYS_20260510%WP3878%HOMO SAPIENS ATM signaling in development and disease CHEK1 MDC1 RNF168-1 STK11 RNF8 HMGN1 HSPB1 BUB1 ATF2 G6PD KAT5 PRKDC TRIM28 TSC2 PPM1D AURKB IKBKG RBBP8 NFKB1 MAPK12 MRE11 TP53BP1 MAPK11 RAD50 TP53 NBN DCLRE1C CDK2 HDAC4 RIF1 LMNB2 NHEJ1 RNF20 ATR ATMIN-1 RNF40 CDK5 PPP5C CDC25A CEP63 PPP2CB;PPP2CA SMC1A MAPK13 ATM MTOR MAPK14 CHEK2 FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260510%WP143%HOMO SAPIENS Fatty acid beta oxidation LPL LIPC CPT2 ACADM ACSL1 ACSL4 ACSL3 HADHB-1 GK GCDH ACSL6 ACSL5 ECHS1 GPD2 LIPE CHKB ACAT1 ACADVL GK2 CPT1B ECI1 LIPF DECR1 HADHA CRAT ACADL ACSS2 SLC25A20 HADH CPT1A ACADS TPI1 DLD PNPLA2 HIPPO SIGNALING REGULATION%WIKIPATHWAYS_20260510%WP4540%HOMO SAPIENS Hippo signaling regulation FLT1 CDH5 FLT3 CDH4 FLT4 CDH3 PLCB3 IGF1R TEAD4 TCF7 CTNNB1 NF2 MST1 PRKAA1 TCF7L2 KDR PLCB1 GNAI3 PDGFRB PDGFRA GNAI2 CDC42 PRKACB-1 TCF7L1 KIT GNA11 SMAD2;SMAD3 PRKAB2 PRKAB1 MET EPHA2 CSF1R STK3 YAP1-1 CDH20 LEF1 CDH22 CDH24 EGFR CDH11 PRKAG1 CDH17 PRKAG2 LATS1 PLCB2 NTRK1 PRKAG3 NGFR PRKCG LATS2 NTRK2 PRKCH CDH10 PRKCB CDH12 INSR PRKCE CDH13 PRKCD CDH15 PRKCA CDH16 WWTR1 CDH18 MTOR CDH19 GNAS-1 PRKAR1B PRKAR1A TEK FGFR4 PRKCQ FGFR3 FGFR2 FGFR1 PRKCZ CDH1 RAC1 PRKAR2B PRKAR2A PRKCI RHOA PRKD3 GNAQ CDH2 PRKAA2 PLCB4 GNAL TEAD1 TEAD2 TEAD3 CDH9 CDH8 PRKACA-1 CDH7 CDH6 TYROSINE KINASE INHIBITORS IN GLIOBLASTOMA%WIKIPATHWAYS_20260510%WP5494%HOMO SAPIENS Tyrosine kinase inhibitors in glioblastoma KRAS GRB2 PTEN RPTOR AKT2 AKT3 JAK2 HRAS AKT1 EREG BTC TSC2 TSC1 RAF1 TGFA TYK2 NRAS SOS1 SOS2 EGF PDK1 JAK1 JAK3 STAT3 MTOR RHEB CANONICAL AND NON CANONICAL TGF B SIGNALING%WIKIPATHWAYS_20260510%WP3874%HOMO SAPIENS Canonical and non canonical TGF B signaling SMAD4 TGFBR2 BMP1 LOX BMPR1A BMPR2 MAPK9 MAPK8 TGFBR1-1 LOXL4 LOXL1 TGFB1 LOXL2 GREM1 MAPK14 SMAD2;SMAD3 AMINO ACID TRANSPORT DEFECTS IEMS %WIKIPATHWAYS_20260510%WP5029%HOMO SAPIENS Amino acid transport defects IEMs SLC6A20 SLC7A7 SLC1A1 SLC6A19 SLC36A2 CLTRN SLC7A9 SLC3A1 SLC3A2 KCNQ2 AND KCNQ3 RELATED EPILEPSY%WIKIPATHWAYS_20260510%WP5599%HOMO SAPIENS KCNQ2 and KCNQ3 related epilepsy PRRT2 TRAPPC2;TRAPPC2B ANK3 GIGYF1 TRAPPC6B KCNQ1 SCN8A KCNQ4 KCNQ5 SCN2A SCN4B ITPR1 CAMK2A NEDD4L DAG1 NEDD4 SNAP25 RAB11A BACE1 AKAP5 CALM1 VAMP2 KCNQ2 KCNQ3 STX1A PRKCE PRKACA-1 FGF13 RAB1A FGF12 TRAPPC3 IRON METABOLISM DISORDERS%WIKIPATHWAYS_20260510%WP5172%HOMO SAPIENS Iron metabolism disorders TFRC SLC40A1 TF HFE CYBRD1 HEPH HAMP FTL-1 STEAP3 FTH1 UQCRFS1 HJV CP BCS1L TFR2 SLC11A2 OXYTOCIN SIGNALING%WIKIPATHWAYS_20260510%WP2889%HOMO SAPIENS Oxytocin signaling OXTR GNAQ PLCD1 CD38 H19 RB E2F1 AND CDK BETA CATENIN IN COLORECTAL CANCER%WIKIPATHWAYS_20260510%WP3969%HOMO SAPIENS H19 Rb E2F1 and CDK beta catenin in colorectal cancer MED1 E2F1 CDK8 TULP3 CCND1 CSRP2 CTNNB1 SOX4 PMAIP1 CDH1 CDK4 JAG1 RB1 MACROH2A1 NAD BIOSYNTHESIS II FROM TRYPTOPHAN%WIKIPATHWAYS_20260510%WP2485%HOMO SAPIENS NAD biosynthesis II from tryptophan KYNU KMO HAAO TDO2 AFMID NADSYN1 NMNAT1 QPRT OSTEOBLAST SIGNALING%WIKIPATHWAYS_20260510%WP322%HOMO SAPIENS Osteoblast signaling PDGFB ITGAV PTH FGF23 SLC17A2 COL1A1 PDGFRB PDGFRA TNFRSF11B ITGB3 PTH1R IBSP TNFSF11 IMMUNE INFILTRATION IN PANCREATIC CANCER%WIKIPATHWAYS_20260510%WP5285%HOMO SAPIENS Immune infiltration in pancreatic cancer VEGFC MMP9 IL2 IL6 IL17D CXCL12 IL17C LGALS9C;LGALS9;LGALS9B IL1B IL13 CXCL8 VEGFD CXCL5;CXCL6 CSF2 VEGFA CXCL2;CXCL3;CXCL1-1 LGALS3 IL12B IL12A TGFB2 IFNG IL23A TGFB3 REG4 IL5 LGALS1 CCL20 CCL28 IL17B CCL13;CCL2 VEGFB IL4 CCL5 IL25 TNF IL17F IL10 TGFB1 IL17A 16P13 11 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260510%WP5502%HOMO SAPIENS 16p13 11 copy number variation syndrome PLAG1 ACTR1A ACTR1B MYH11 BMERB1 DCP2-1 NDE1 DCTN6 MARF1 DCP1A ACTR10 RAPGEF4 DCTN1 DCTN4 PLAGL1 ABCC6 PLK1 GATA3 ABCC1 PAFAH1B1 RAP1A CEP20 KIAA0753 OFD1-1 DISC1 BREAST CANCER PATHWAY%WIKIPATHWAYS_20260510%WP4262%HOMO SAPIENS Breast cancer pathway SKP1 PGR SP1 CTNNB1 DVL1 NOTCH2 DVL2 DVL3 NOTCH1 BRCA1 TCF7L2 CDK6 CDK4 AXIN1 JUN ESR1 NFKB2 PIK3CA MAPK1 CETN3 RAF1 TCF7L1 ATR FGF2 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 HES1 MRE11 BRCA2 NCOA1 FGF20 RAD50 RAD51 NBN FGF23 FGF22 FGF21 HEY2 HEYL FGF17 FGF16 NOTCH3 NOTCH4 FGF19 FGF18 WNT4 CDKN1A FGF10 FLT4 PTEN FRAT2 PIK3CD APC2 IGF1R CCND1 TCF7 MYC AKT2 AKT3 HRAS NCOA3 ERBB2 AXIN2 TNFSF11 KIT SOS1 SOS2 TP53 LEF1 LRP5 HES5 EGFR LRP6 WNT1 RPS6KB1 RPS6KB2 CSNK1A1 CSNK2A2 FZD6 MTOR CSNK2B APC KRAS GRB2 SHC1-1 FGFR1 IGF1 ARAF GSK3B JAG2 DLL1 WNT2B FZD10 POLK DLL3 AKT1 DLL4 WNT5B DDB2 WNT16 SHC4 SFRP4 SHC3 PARP1 SHC2 PIK3R3 FOS PIK3R2 PIK3R1 WNT6 WNT11 NRAS WNT2 WNT3 WNT10B E2F1 WNT10A E2F2 FZD3 E2F3 EGF FZD2 BAK1 FZD5 GADD45B GADD45A WNT3A WNT7B FZD7 GADD45G FGF1 FZD9 BAX WNT7A FZD8 FZD1 MAP2K2;MAP2K1 WNT5A CSNK2A1;CSNK2A3 RB1 ATM MAPK3 BRAF ESR2 HEY1 RELATIONSHIP BETWEEN INFLAMMATION COX 2 AND EGFR%WIKIPATHWAYS_20260510%WP4483%HOMO SAPIENS Relationship between inflammation COX 2 and EGFR KRAS PLA1A PIK3CD PIK3CB PIK3CG PTGS2-2 AKT2 AKT3 MMP1 HRAS CYP19A1 AKT1 ESR1 PIK3CA MAPK1 PTGES2 NRAS PTGER4 SRC PTGER1 PTGER2 PTGER3 EGFR MAPK3 BRAF EXTRAFOLLICULAR AND FOLLICULAR B CELL ACTIVATION BY SARS COV 2%WIKIPATHWAYS_20260510%WP5218%HOMO SAPIENS Extrafollicular and follicular B cell activation by SARS CoV 2 IL2 GPR183 CXCL12 SELL TNFSF13B CD69 PDCD1 IFIT2 CRP ETS1 CCR7 IFNAR2 FOXO1-1 CXCR5 LOC102723996;ICOSLG BACH2 IFITM3;IFITM2;IFITM1 BLNK ICOS TMSB10 CCL19 FCRL5 CD40LG EBI3 CD1D CD79A SLAMF7 MAF XBP1 CCL21 SH2D1A PTPRC AICDA CD22 LOC110384692;C4A;C4B_2;C4B STAT5A SYK TNF CD82 BTLA IL6 BCL6 HSPA8 ISG15 ITGB2 TLR7 CD80 PTCRA IL21 ITGAX MS4A1 CD19 CR2 MFGE8 CXCL13 IRF8 IL12A IFNG IRF4 TLR4 BCR CD40 PRDM1 TBX21 CR1L;CR1 CXCR4 C3-1 IL4 IL10 ZEB2 PAX5 CAFFEINE IN MYOCYTES%WIKIPATHWAYS_20260510%WP5603%HOMO SAPIENS Caffeine in myocytes MYL2 MYL6 ACTG1 ACTC1;ACTG2 MYH6 MYH11 TPM2 MYL1 MYL3 TNNT1 TPM4 TPM1 ACTA2 MYH13 TNNI1 TNNI2 TNNI3 TNNC2 MYLPF MYH1 RYR1 MYH3 RYR2 TNNT2 TNNT3 MYH8 ACTA1 MYH7 TPM3 RYR3 ACTB-1 TNNC1 TCA CYCLE NUTRIENT USE AND INVASIVENESS OF OVARIAN CANCER%WIKIPATHWAYS_20260510%WP2868%HOMO SAPIENS TCA cycle nutrient use and invasiveness of ovarian cancer MAPK3 STAT3 MAPK1 JAK1 EGFR HIPPO YAP SIGNALING%WIKIPATHWAYS_20260510%WP4537%HOMO SAPIENS Hippo YAP signaling CXCL10 MAP4K3 MAP4K4 NDRG1 TEAD4 TNIK SAV1 MAP4K1 STK3 YAP1-1 NF2 MST1 LATS1 TEAD1 TEAD2 LATS2 TEAD3 WWTR1 STK38L RASSF1 MAP4K2 MINK1 MALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260510%WP5320%HOMO SAPIENS Male steroid hormones in cardiomyocyte energy metabolism CYP11A1 SRD5A2 CYP19A1 UGT1A1;UGT1A6 SRD5A1 HSD3B1;HSD3B2 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 CYP17A1 HSD17B3 HSD17B2 IL10 ANTI INFLAMMATORY SIGNALING%WIKIPATHWAYS_20260510%WP4495%HOMO SAPIENS IL10 anti inflammatory signaling STAT1 HMOX1 IL6 BLVRB IL1A BLVRA IL10RB IL10RA STAT2 IL10 STAT3 JAK1 COLCHICINE METABOLIC PATHWAY%WIKIPATHWAYS_20260510%WP2536%HOMO SAPIENS Colchicine metabolic pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ESTROGEN SYNTHESIS AND METABOLISM%WIKIPATHWAYS_20260510%WP5276%HOMO SAPIENS Estrogen synthesis and metabolism CYP2C9;CYP2C19 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 HSD17B4 HSD17B7 HSD17B3 HSD17B1 HSD17B2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 COMT CYP19A1 HSD17B8 HSD17B10 CYP1B1 SILDENAFIL TREATMENT%WIKIPATHWAYS_20260510%WP5294%HOMO SAPIENS Sildenafil treatment PRKN PDE4C GAPDH-1 NOS1 PPARGC1A NRF1 GSK3B AKT2 AKT3 PDE4D-1 GUCY1B1 AKT1 PRKG1 GUCY1A2 GUCY1A1 TFAM-1 NOS3 ZNF746 PDE5A NOS2 PDE4B PDE4A JOUBERT SYNDROME%WIKIPATHWAYS_20260510%WP4656%HOMO SAPIENS Joubert syndrome ZNF423 DVL1 KAT5 DVL3 CEP120 CEP97 ARMC9 RPGRIP1L AHI1 CEP104 ARL3 ATF4 INPP5E MTOR CETN1 CCP110 PIBF1 ARR3 BBS2 CSPP1 ANKS6 BBS1 RHEB INVS TMEM138 ARL2 CPLANE1 NPHP1 MYO6 RP2 PDE6B TMEM231 PDE6A NEK8 PCNT TMEM17 RAB3IP NIN MKS1 TMEM237 CEP164 KIAA0586 PDE6D UNC119 NPHP3 B9D2 MYO5A FLNA RAB8A CEP41 TCTN3 TCTN2 TCTN1 BBS9 CEP290 BBS7 CC2D2A BBS5 BBS4 PARP1 MRE11 RHOA RAD50 TMEM216 ARL13B SHH TMEM67 OFD1-1 ATM TTC8 CETN2 B9D1 UREA CYCLE AND RELATED DISEASES%WIKIPATHWAYS_20260510%WP4571%HOMO SAPIENS Urea cycle and related diseases ARG1 ASS1 CPS1 SLC25A15 ASL NAGS OTC GLS2 SLC25A13 FEMALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260510%WP5318%HOMO SAPIENS Female steroid hormones in cardiomyocyte energy metabolism STK11 HADHB-1 ACADM MTTP SLC2A4 PPARA AKT2 SOD2 APOB ESR1 ESRRA NOS3 PPARGC1B ACLY ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY%WIKIPATHWAYS_20260510%WP2118%HOMO SAPIENS Arrhythmogenic right ventricular cardiomyopathy ITGAV ITGA2 ITGB7 ITGA1 CTNNA1 TCF7 CTNNB1 CTNNA3 TCF7L2 CTNNA2 ACTN4 DAG1 ITGB4 TCF7L1 CACNG2 SLC8A1 CACNA2D1 GJA1 LAMA2 ITGA5 LEF1 ITGA11 ITGB5 ITGB8 ITGA8 ITGA7 CACNB1 ITGA9 CACNB3 ITGA3 SGCD SGCA EMD SGCB ITGA6 SGCG CACNA1D ACTG1 DSP ACTN3 ACTN2 CACNA1C CACNA2D3 CACNA2D2 LMNA CACNA2D4 CACNB2 CACNB4 DMD PKP2 DSC2 CACNA1F ITGB6 CACNG6 ACTN1 CACNG7 CACNG8 CACNA1S CACNG1 CACNG3 CACNG4 CACNG5 CDH2 ITGB1 ITGA10 RYR2 ITGA2B ATP2A2 JUP ITGA4 DES ACTB-1 ITGB3 DSG2 GLYCOSPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260510%WP5292%HOMO SAPIENS Glycosphingolipid metabolism GBA2 GALC NEU3 B3GALT2 NEU4 B4GALT6 B4GALT5 ST3GAL5 B4GALNT1 B4GALT4 ARSA GAL3ST1 GLA UGT8 UGCG B4GALT3 B3GNT5 B3GALT1 A4GALT GBA A3GALT2 INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260510%WP5120%HOMO SAPIENS Inclusion body myositis NCSTN PSEN2 APP BACE1 MAPT PSEN1 NFKB2 PSENEN NFKB1 MSTN SIRT1 CELLS AND MOLECULES INVOLVED IN LOCAL ACUTE INFLAMMATORY RESPONSE %WIKIPATHWAYS_20260510%WP4493%HOMO SAPIENS Cells and molecules involved in local acute inflammatory response SELPLG C7 SELP IL6 ITGAL ICAM1 IL1A ITGB1 ITGB2 CXCL8 C3-1 TNF VCAM1 ITGA4 KNG1 C5 C6 TGIF DISRUPTION OF SHH SIGNALING%WIKIPATHWAYS_20260510%WP3674%HOMO SAPIENS Tgif disruption of Shh signaling TGIF1-1 FGF8 TGIF2 FOXG1 NKX2-1 NODAL GLI3 SHH SMAD2;SMAD3 LDLRAD4 INTRONIC SNP EFFECT ON COVID PATIENTS%WIKIPATHWAYS_20260510%WP4904%HOMO SAPIENS LDLRAD4 intronic SNP effect on COVID patients TGFBR1-1 NEDD4 PMEPA1 TGFBR2 LDLRAD4 ATG16L1 SMAD2;SMAD3 NOTCH SIGNALING%WIKIPATHWAYS_20260510%WP61%HOMO SAPIENS Notch signaling EP300 MAML1 SKP1 NUMB SNW1 NOTCH2 NOTCH1 JAK2 CUL1 FHL1 JAG1 NCOR1 NFKB1 PSEN2 HES6 SRC HES5 STAT3 MTOR HDAC2 HDAC1 TLE1 GSK3B JAG2 DLL1 DLL3 AKT1 DLL4 HES1 SAP30 PIK3R2 NCOR2 PIK3R1 FBXW7 LCK MAML2 ADAM17 PSEN1 RBPJ CIR1 NUMBL DTX1 MAGEA4;MAGEA1;MAGEA3;MAGEA2;MAGEA2B;MAGEA12;MAGEA6;MAGEA10-MAGEA5;MAGEA5;MAGEA9B;MAGEA9;MAGEA8;MAGEA11 HEY2 PSENEN APH1B MAML3 SPEN ITCH APH1A NCSTN RING1 NOTCH3 NOTCH4 SULINDAC METABOLIC PATHWAY%WIKIPATHWAYS_20260510%WP2542%HOMO SAPIENS Sulindac metabolic pathway MSRA MSRB2 CYP1A2 MSRB3 FMO3 CYP1B1 METABOLISM OF SPHINGOLIPIDS IN ER AND GOLGI APPARATUS%WIKIPATHWAYS_20260510%WP4142%HOMO SAPIENS Metabolism of sphingolipids in ER and Golgi apparatus B3GALT2 B4GALNT1 SGPL1 GALNT1 CERS3 SPHK2 SGPP2 SGPP1 B4GALT2 B3GALNT1 B4GALT1 CERK GALNT16 SGMS1 ST6GALNAC3 SPHK1 SGMS2 UGT8 UGCG KDSR B3GALT1 MEASLES VIRUS INFECTION%WIKIPATHWAYS_20260510%WP4630%HOMO SAPIENS Measles virus infection IL2 IL2RB CCNE2 BCL2 CD28 TRADD CDK6 NFKBIB CDK4 IKBKB NFKBIA JUN IFNAR2 NFKB2 CHUK PIK3CA TRAF6 IKBKG NFKB1 IFNAR1 IFNB1-4 RACK1 STAT2 HSPA2 MX1-1 CDK2 ADAR IL2RG JAK3 CLEC4M;CD209-2 IFIH1 TBK1 HSPA8 IKBKE DDX58 MYD88 IRF3 RAB9A IRF7 TLR7 IL12B IL12A IL1A MSN SLAMF1 EIF2AK1 HSPA6 EIF2AK3 EIF2AK4 RCHY1 HSPA1L EIF3H NECTIN4 RAB9B PIK3CD TNFAIP3 PIK3CB CCND1 IRAK4 APAF1 FASLG BBC3 CASP8 FADD TP53 BID BCL2L1 TLR2 JAK1 STAT5A MAP3K7 STAT5B STAT1 CSNK2A2 TAB2 STAT3 CSNK2B MAVS IL6 TRAF3 IL1B CBLB CASP9 HSPA1A;HSPA1B CD3G CASP3 CD3E CD3D EIF2AK2 OAS1 PIK3R3 FOS TYK2 PIK3R2 OAS3 PIK3R1 TLR9 IRF9 TLR4 CYCS-1 BAK1 MAPK10 BAD RELA EIF2S1 MAPK9 BAX CDKN1B MAPK8 CCND3 CCNE1 CSNK2A1;CSNK2A3 FAS IRAK1 IL2RA TP73 CCND2 LACTATE SHUTTLE IN GLIAL CELLS%WIKIPATHWAYS_20260510%WP5314%HOMO SAPIENS Lactate shuttle in glial cells HK1 LDHA CA2 CA4 SLC16A7 NUDT14 SLC16A1 SLC4A4 LDHB SLC16A3 SLC1A2 SLC2A1 SUDDEN INFANT DEATH SYNDROME SIDS SUSCEPTIBILITY PATHWAYS%WIKIPATHWAYS_20260510%WP706%HOMO SAPIENS Sudden infant death syndrome SIDS susceptibility pathways SOX2 EP300 THRB TACR1 SCN4B SP1 CTNNB1 IL13 DLX2 TPH1 CHAT POU5F1;POU5F1B GATA2 CREBBP MAP2 JUN VEGFA NFKB2 FEV G6PC1 NFKB1 CHRM2 PBX1 MYB NANOG;NANOGP8 TF PPARGC1A NEUROD1 GJA1 BDNF GCK PAH CREM CAV3 PRKAR1B HDAC1 PRKAR1A GABRA1 FOXM1 REST HTR2A SP3 IL1RN PRKAR2B HTR1A HDAC9 PRKAR2A TPPP RET HES1 IL1A GNB3 ASCL1 DDC YWHAE TH MAOA RYR2 YWHAB CHRNA7;CHRFAM7A CTCF HSP90B1 AR PRKACA-1 YWHAQ POU2F2 NKX3-1 SST YWHAG YWHAH YWHAZ KCNQ1 VIPR1 VIPR2 PKNOX1 KCNH2 TSPYL1 GPD1L-1 POU3F2 ADCYAP1 MEF2C ADCYAP1R1 MAZ SLC9A3 DEAF1 SLC1A3 SCN3B IL6R TAC1 SPTBN1 EGR1 PHOX2B PHOX2A BHLHE40 NFYA-1 CC2D1A CDCA7L SCN5A PPARGC1B SNTA1 PRKACB-1 HTR3A SSTR1 NOS1AP SLC25A4 ATP1A3 HSPD1 KCNJ8 TPH2 SNAP25 MBD1 PLP1 LOC110384692;C4A;C4B_2;C4B VAMP2 HES5 TNF HADHA NTRK2 GRIN1 CPT1A FMO3 IL6 GAPDH-1 ALDOA ACADM IL1B MECP2 CXCL8 ECE1 CHRNA4 CASP3 RORA CHRNB4 RUNX3 SSTR2 CREB1 NGF AVP GATA3 HADHB-1 HIF1A CEBPB AQP4 NR3C1 SLC6A4 TLX3 IL10 NKX2-2 YBX1 TP73 EN1 CHRNB2 LMX1B ESR2 EDA SIGNALING IN HAIR FOLLICLE DEVELOPMENT%WIKIPATHWAYS_20260510%WP3930%HOMO SAPIENS EDA signaling in hair follicle development WNT3 EDARADD SOSTDC1 BMP1 RELB EDA PTCH1 LTB SHH DKK4 EDAR DKK1 GLI1 INTEGRIN MEDIATED CELL ADHESION%WIKIPATHWAYS_20260510%WP185%HOMO SAPIENS Integrin mediated cell adhesion ITGAV FYN CAPN3 VAV2 ITGB4 MAPK1 RAF1 MAP2K6 MAP2K3 MAP2K5 ITGA5 TLN1 RHO CAV3 CAV2 VAV3 SELENOP ILK PXN ITGA10 ITGA2B ITGA2 ITGB7 CAPN10 RAC3 ITGA1 RAPGEF1 AKT2 AKT3 ARHGEF7 DOCK1 HRAS ROCK1 ROCK2 MYPN CDC42 CAV1 CSK MAPK6 MAPK4 MAPK12 SOS1 BCAR1 MYLK2 CAPN9 CAPNS1 CAPN6 SRC CAPN7 RAP1A CAPN5 CAPN2 CAPN1 TNS1 VASP GIT2 SORBS1 CAPN11 ZYX ITGA11 ITGB5 ITGAE ITGB8 ITGAD ITGA8 ITGA7 ITGA9 GRB2 ITGA3 ITGAL SHC1-1 ITGAM BUB1B-PAK6;PAK6 ITGB2 ITGA6 ARAF ITGAX PDPK1 RAC1 AKT1 ITGB6 CRK VCL SHC3 PIK3R2 PAK1 PAK3 PAK2 PAK4 MAPK10 ITGB1 RAP1B MAP2K2;MAP2K1 MAPK7 ITGA4 BRAF ITGB3 PTK2 ASPIRIN AND MIRNAS%WIKIPATHWAYS_20260510%WP4707%HOMO SAPIENS Aspirin and miRNAs ABCC4 WNT1 MVD VEGFA PPARA PTGS2-2 PTGS1 NOS3 PDK1 NFKB1 GABA AND GLUTAMATE SIGNALLING IN EPILEPTOGENESIS%WIKIPATHWAYS_20260510%WP5600%HOMO SAPIENS GABA and glutamate signalling in epileptogenesis GRIK5 GRIK3 GRIK4 GRIK1 NR4A1 PLCB1 CREBBP MAPK1 GRIK2 GRIP1 SLC6A1 SLC32A1 GAD1 SLC6A11 GABRG1 CACNG2 GABRB3 GABRB2 GABRB1 FFAR1 GABRG3;GABRG2 MAP1LC3B2;MAP1LC3B-1 PRKCA GABRE SLC7A11 GABRD GABRQ HDAC1 GABRA2 GABRA1 ORAI1 GABRP KIF5C SLC12A5 GABRA6 GABRA5 GABRA4 STIM1 GABRA3 SLC6A8 CACNG8 GNAQ PPP2CB;PPP2CA MBD5 HDAC10 GRIN2C GLUL GRIN3B GRIN3A SUMO1 CAMK2A SLC1A3 AP2A1 AP2A2 AP2B1 GNA11 ARC GRIA1 GRIA2 GRIN2D GRM1 GRM5 GLS2 SRC ABAT P4HB STAT1 HOMER1 GRIN2B FRMPD3 GRIN1 ADARB1 DLG4 ZFYVE27 SLC6A12 SLC1A7 NETO2 STAT3 CPEB3 CABIN1 GABRR3 GABRR2 GABRR1 NPTN DLGAP3 GAPDH-1 C1QL3 C1QL2 PICK1 GRM2 NWD1 SNX27 UBQLN4 GRM4 ATAD1 GRM7 SYVN1 GRM6 LHFPL4 GRM8 SNX14 SDCBP GRM3 NRG1 NRXN3 SLC6A13 SLC6A6 GRIN2A CRTC1 CDH2 ERBB4 PDIA2 GRIA3 MAP2K2;MAP2K1 MAPK3 SLC1A1 SLC1A2 SLC1A6 EFNB2 GRIA4 SH3GL2 FRAGILE X SYNDROME%WIKIPATHWAYS_20260510%WP4549%HOMO SAPIENS Fragile X syndrome FYN GPHN CDKN2A ALDH3A2 PLCB1 EIF4E DAG1 MAPK1 RAF1 GRIP1 SLC6A1 AP2S1 AP2M1 GAD1 ABCD3 BDNF PDK1 GABRB2 CLTCL1 GABRG3;GABRG2 MAP1LC3B2;MAP1LC3B-1 PRKCA EEF1A1 EIF4G1 MKNK1 GABRD MMP9 SH3GL3 PRKAR1A GABRA1 CYFIP2 AGAP2 ITPR1 CLTC CLTB CLTA RAP1GAP DNM1 MAP1B SHANK1 AKAP5 FMR1 PRKACA-1 PTEN PIK3CB PPP2R5B RPTOR CAMK2B DEPTOR DICER1 CAMK2A TARBP2 MLST8 SLC16A1 TSC2 AP2A1 TSC1 AP2B1 TTI1 AKT1S1 SOS1 ARC GRIA1 TELO2 GRIA2 GRM1 GRM5 SRC SYNGAP1 ABAT CAMK4 CAMK1 HOMER1 RPS6KB1 GRIN2B NTRK2 GRIN1 DLG4 CPT1A MTOR HCN1 CYFIP1 RHEB DLGAP3 KRAS GRB2 PICK1 SHC1-1 CNR1 AGO2 EIF4A1 ARAF MECP2 SH3GL1 GRIP2 TBC1D7;TBC1D7-LOC100130357 HOXB8 EIF4EBP2 ARHGAP32 GAB1 PPP1CA KCNC1 APP TECR AKT1 DUSP3 KCND2 DNM2 ALDH5A1 EPS8L1 PTPN5 PPP3CA GRIN2A CREB1 PTPN11 NF1 MAP2K2;MAP2K1 EPHA4 PLCG1 BRAF ENTEROCYTE CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260510%WP5333%HOMO SAPIENS Enterocyte cholesterol metabolism APOA4 LDLR CYP51A1 MSMO1 TM7SF2 NSDHL CD36 LBR ABCG8 ABCG5 HMGCS1-1 DGAT1 LSS SLC27A4 SAR1B MTTP HSD17B7 EBP ABCA1 IDI1 NPC1L1 FDPS MVK SC5D MGAT1 DHCR7 APOB ACAT2 PMVK DHCR24 FABP2 MVD FDFT1 SQLE HMGCR APOA1 LNCRNA LIKE NMRK2 IN TRANSLOCATION RENAL CELL CARCINOMA%WIKIPATHWAYS_20260510%WP5519%HOMO SAPIENS LncRNA like NMRK2 in translocation renal cell carcinoma NONO FH TFE3 SLC19A2 CS NMRK2 MDH2 HSPE1 SIGNALING LIPIDS%WIKIPATHWAYS_20260510%WP5584%HOMO SAPIENS Signaling lipids GPX4 CYP2C9;CYP2C19 CYP8B1 PLA1A CYP7A1 CYP2B6 ALOX15 ALOX12 PTGS2-2 FADS2 PLCB1 TBXAS1 PLA2G1B PRXL2B HPGD LTC4S CYP7B1 LTA4H CYP27A1 CBR1-1 ALOX5 PTGES PTGDS EPHX2 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LUNG FIBROSIS%WIKIPATHWAYS_20260510%WP3624%HOMO SAPIENS Lung fibrosis HGF CCL3L1;CCL3L3;CCL3;CCL18 IL13 TIMP1 TERT EDN1 CCR2 CXCL2;CXCL3;CXCL1-1 NFE2L2 GREM1 CCL11 BMP7 IL5 ATP11A CMA1 PLAU TNF CYSLTR2 MMP2 MMP9 CALCA HMOX1 IL6 ELMOD2 FGF2 IL1B IGF1 MECP2 DSP CXCL8 CSF3 FGF7 CSF2 MT2A IL12B TGFA FAM13A SKIL SFTPC RTEL1 PDGFB PARN SMAD7 CCN2 DPP9 STN1 MUC5B PTX3 EGF CEBPB SPP1 PDGFA FGF1 CCL13;CCL2 SERPINA1 IL4 CCL4L2;CCL4L1;CCL4 CCL5 TGFB1 CCR3 ATR SIGNALING%WIKIPATHWAYS_20260510%WP3875%HOMO SAPIENS ATR signaling CHEK1 RPA2 TOPBP1 ATRIP HUS1 RAD9B RPA3 RAD1 RAD9A ATR RPA1 17P13 3 YWHAE COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5376%HOMO SAPIENS 17p13 3 YWHAE copy number variation YWHAH YWHAZ DCTN3 PAFAH1B1 NDEL1 DBH DDC YWHAE CDK5 TH DYNC1H1 YWHAB PPP2CB;PPP2CA DCTN6 DCTN5 DISC1 DCTN2 DCTN1 DCTN4 YWHAQ YWHAG HEMATOPOIETIC STEM CELL DIFFERENTIATION%WIKIPATHWAYS_20260510%WP2849%HOMO SAPIENS Hematopoietic stem cell differentiation THRB IL3 ACVR1B PIM1 NFATC2 KCNH2 VAV1 CIITA FOSB NOTCH1 LMO2 GATA2 GATA1 EPO KLF1 MYB HES6 KITLG IL5 CD34 LEF1 STAT5A IKZF1 TPO IL6 NCKAP1L IL1B CSF3 CSF2 CSF1 FOS RUNX1 IL1A TRAF3IP3 LYL1 HMGN5 TRIM29 RHOH IRF5 TNXB SEC14L2 CXCR4 MUC1 MXI1 NFE2 RIOK3 ITGA2B FLI1 SPI1 GP9 ITGB3 ENERGY METABOLISM%WIKIPATHWAYS_20260510%WP1541%HOMO SAPIENS Energy metabolism EP300 HDAC1 MED1 PRMT1 RXRA PPARA ATF2 NRF1 GSK3B PRKAA1 MEF2C SIRT1 MEF2B;BORCS8-MEF2B SIRT3 PPP3CB FOXO1-1 ESRRA PPP3CA PPARGC1B PPP3CC GABPA PPARG MEF2D CREB1 CAMK2G NCOA1 PRKAB2 PRKAB1 PPP3R1 PPARGC1A PRKAA2 PPARD FOXO3 UCP3 CAMK4 PRKAG1 PRKAG2 PRKAG3 TFB1M UCP2 MEF2A TFB2M PPRC1 TFAM-1 MYBBP1A MAPK14 22Q11 2 DISTAL CNV%WIKIPATHWAYS_20260510%WP5546%HOMO SAPIENS 22q11 2 distal CNV RPS17 CHEK1 RPS16 RPS19 RPS18 CWC22 ROPN1L RPS11 RPS10 RBX1 SNRPA1 RPS13 RPS12 SRRM2 RSPH6A SF3B4 ZNF280D;ZNF280A SF3B5 RPS9 SF3B2 AQR CUL2 SF3B3 RPS7 ELOC-1 RPS8 RPS5 ELOB DNAJB13 RPSA CRNKL1 PDIA4 IGLL5;IGLL1 RAB36 DNAJB11 ERP29 SNRPB2 PPIE MAPK1 SNRPG-2 DYDC1 SNRNP200 SF3B1 ATF6 SF3A3 UBA6 CABP1 SF3A1 AK8 CD79B SDF2L1 SF3A2 CALR-1 CD79A CWC15 TDRD3 XBP1 RPS29 SNRNP40 RPS20 RACK1 PHF5A HYOU1 RPS21 RPS24 RPS23 CDC16 IQUB ARIH1 TOP3B CCDC116 BUD31 PLRG1 NME5 YDJC RBM22 RSPH9 PPM1F RNF113A RPS15A RPS3 LRP4 PRAME RPS2 RPS27A RILP UGGT1 PPIL2 CDC5L RSPH3 XAB2 YPEL1 PTPA FAU PPIL4 PPIL6 GNAZ NEDD4 UBA1 PRKN BCR CANX HSP90B1 HSPA5 SNW1 UBE3A CAMK2A TP53 MDM2-2 CAMK4 PPIB CAMK1 RPS6 EFTUD2 SNRPD2 SNRPD1 SNRPD3 SNRPF SNRPB PRPF8 SNRPE-2 CBL SOX9 PAK1 PAK2 PDIA2 RNF19B PPIL1-1 RPS15 DHX16 RPS14 VPREB1 ALZHEIMER 39 S DISEASE%WIKIPATHWAYS_20260510%WP5124%HOMO SAPIENS Alzheimer 39 s disease DVL1 DVL2 MCU DVL3 MME AXIN1 IKBKB TPTEP2-CSNK1E;CSNK1E CHUK MAPK1 RAF1 NOS2 NFKB1 KIF5A PSEN2 XBP1 SLC25A5 ATG13 APOE ULK1 HSD17B10 ATG101 NOS1 KIF5C KIF5B ITPR1 ITPR2 CACNA1D ITPR3 CACNA1C RB1CC1 CACNA1F CACNA1S BECN1 GNAQ APBB1 APH1B CALM1 CALM2 AMBRA1 ATP2A3 ATP2A2 PSMA4 DKK1 EIF2AK3 RYR3 WNT4 PLCB3 GRIN2C PTGS2-2 IRS1 PIK3R4 INS;INS-IGF2 APAF1 SLC25A4 CASP7 CASP8 FADD BID CALM3;CALM1 CAPN2 CAPN1 DKK4 TNF MAPT IL6 NOX1 GSK3B TUBAL3 CASP9 TUBA1C TUBA1A WIPI1 TUBB1 CASP3 WIPI2 AKT1 TUBA3E;TUBA3C-1 ATG14 TUBB2B;TUBB2A MAP3K5 TUBB4B TUBA4A EIF2AK2 ATG2A TUBB4A;TUBB;TUBB8B;TUBB8 ERN1 MAP2K7 TUBB3;TUBB6 TUBA8 CYCS-1 PSEN1 MAPK10 RELA EIF2S1 CDK5 MAPK9 MAPK8 FZD1 MAP2K2;MAP2K1 WNT5A CSNK2A1;CSNK2A3 FAS MAPK3 BRAF CDK5R1 CTNNB1 DDIT3 PLCB1 PPIF PIK3CA RTN4 TRAF2 ATF6 NOX4 PLCB2 ATF4 SNCA PSMD9 PSMD6 PSMD4 PSMD3 PSMD1 PSMC2-1 VDAC3 NRBF2 CYBB ATG2B IDE PSMA5 PSMA6 PSMA3 PSMA1 PSMA7 PSMA8 VDAC1 PSMB6 PSMB7 CSF1 PSMB4 PSMB5 PSMB2 PSMB3 PPP3CC PSMB1 PSMA2-1 PSMC5 PSMC3 PSMC1 VDAC2-1 PPID RTN3 PSMD14 SEM1 IL1A GPR83 KLC1 KLC4 TNFRSF1A KLC3 KLC2 NAE1 ATP2A1 SLC25A6 PSENEN BECN2 ADRM1 SLC25A31 APH1A NCSTN CHRNA7;CHRFAM7A IRS4 LRP1 LPL PSMD8 FRAT2 PSMD7 PIK3CD PIK3CB PSMD2 APC2 AKT2 AKT3 IRS2 PIK3C3 HRAS AGER AXIN2 ULK2 GRIN2D LRP5 LRP6 WNT1 GRIN2B GRIN1 CSNK1A1 CSNK2A2 INSR PSMC6 DKK2 PSMC4 FZD6 MTOR CSNK2B APC PSMD12 KRAS PSMD13 GAPDH-1 IL1B CALML6 ARAF CALML3 CALML4 WNT2B APP FZD10 WNT5B PPP3CB WNT16 PPP3CA SFRP4 PIK3R3 PIK3R2 PIK3R1 ADAM10 WNT6 GRIN2A WNT11 NRAS WNT2 WNT3 WNT10B BACE1 PPP3R1 WNT10A ADAM17 FZD3 FZD2 FZD5 PLCB4 BAD WNT3A WNT7B FZD7 FZD9 WNT7A FZD8 TRANS SULFURATION PATHWAY%WIKIPATHWAYS_20260510%WP2333%HOMO SAPIENS Trans sulfuration pathway MPST CTH GCLM CSAD DNMT1 AHCY MAT2B GOT1-1 CBS;CBSL MTR-1 APOPTOSIS RELATED NETWORK DUE TO ALTERED NOTCH3 IN OVARIAN CANCER%WIKIPATHWAYS_20260510%WP2864%HOMO SAPIENS Apoptosis related network due to altered Notch3 in ovarian cancer TRAF1 CTNNA1 PTK2B CUL1 AXIN1 ETS1 BIRC5 MAPK1 NFKB1 GCLC CASP7 HSPD1 IL7R APOE VIM RPS6KB1 TNF ANXA5 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A THBS1 HDAC1 HSPB1 VAV3 SQSTM1 NRG1 APP AKT1 F2R ERBB3 ERN1 SMAD7 BCL3 NQO1 PAK2 RIPK2 YBX3 SOCS3 CDKN1B SERBP1-1 IER3 CARD14 BEX3 ABL1 PKN1 RNF7 HELLS NET1 JUND TNFRSF21 HSPA5 CUL5 CDKN1A PTK2 MIR 509 3P ALTERATION OF YAP1 ECM AXIS%WIKIPATHWAYS_20260510%WP3967%HOMO SAPIENS miR 509 3p alteration of YAP1 ECM axis BCAR1 TEAD4 YAP1-1 FN1 EDNRA COL1A1 COL3A1 TEAD1 SPARC TEAD2 TEAD3 PBX3 THBS2 COL5A1 GPC6 SNAI2 METABOLIC PATHWAY OF LDL HDL AND TG INCLUDING DISEASES%WIKIPATHWAYS_20260510%WP4522%HOMO SAPIENS Metabolic pathway of LDL HDL and TG including diseases LPL LCAT LIPC LDLR MTTP APOE ABCA1 APOB PCSK9 LIPG APOC2 LDLRAP1 ANXA2 APOA2 APOA1 SCARB1 CETP IL26 SIGNALING%WIKIPATHWAYS_20260510%WP5347%HOMO SAPIENS IL26 signaling MMP9 IL6 ICAM1 MPO IL1B DDIT3 CXCL8 CTSK JAK2 MMP1 RORC IL20RA CASP3 AKT1 NFKBIA CSF2 JUN IL10RB IL33 PIK3CA MAPK1 TYK2 SMAD2;SMAD3 TNFSF11 EPHA3 CCL20 ACTA2 SOCS3 RELA JAK1 MAPK9 BAX NFATC1 MAPK8 STAT1 TNF MAPK3 IL10 IL17A STAT3 IL26 MAPK14 DCSTAMP DEFB4A;DEFB4B ATP6V0D2 MYD88 DISTINCT INPUT OUTPUT PATHWAY%WIKIPATHWAYS_20260510%WP3877%HOMO SAPIENS MYD88 distinct input output pathway TIFA TLR9 TLR10 TLR6 TLR5 IL1A TLR4 TLR2 MYD88 TLR7 UBE2V1 UBE2N TLR8 TLR1 IRAK1 JUN TRAF6 NFKB1 BIOMARKERS FOR UREA CYCLE DISORDERS%WIKIPATHWAYS_20260510%WP4583%HOMO SAPIENS Biomarkers for urea cycle disorders GAMT ARG1 GATM F10 ASS1 F7 ASL GOT1-1 NAGS OTC GLS2 GPT ANK2 PATHWAY IN EPILEPSY DEVELOPMENT%WIKIPATHWAYS_20260510%WP5557%HOMO SAPIENS ANK2 pathway in epilepsy development PRRT2 SPTBN4 ANK3 SNAP25 BRSK1 BRSK2 ANK2 PRICKLE1 L1CAM SCN2A EIF2A SEMA3A DDIT3 KCNQ2 SPTAN1 CSNK2A1;CSNK2A3 ATF4 MAPT CSNK2A2 EIF2AK3 SCN5A CSNK2B DNM1L ATF6 CHRONIC HYPERGLYCEMIA IMPAIRMENT OF NEURON FUNCTION%WIKIPATHWAYS_20260510%WP5283%HOMO SAPIENS Chronic hyperglycemia impairment of neuron function MMP9 SCN8A PRKCQ MMP21 MMP20 MMP25 MMP12 MMP24 MMP27 SCN9A TKTL1 MMP10 MMP11 PRKCZ MMP1 SCN10A MMP16 AGER MMP15 MMP17 MMP19 MMP7 PRKCI NOS2 SORD PRKD3 SNAP25 MMP13 MMP28 MMP3 BDNF TRPA1 MMP8 C3-1 MMP23B TRPV1 PRKCG PRKCH PRKCB PRKCE MMP14 PRKCD PRKCA MMP2 SLC2A1 INITIATION OF TRANSCRIPTION AND TRANSLATION ELONGATION AT THE HIV 1 LTR%WIKIPATHWAYS_20260510%WP3414%HOMO SAPIENS Initiation of transcription and translation elongation at the HIV 1 LTR HDAC2 EP300 HDAC1 NFATC3 NFATC4 NFATC2 SP1 CREBBP NFKBIA CCNT1 HDAC9 NELFA PPP3CB NELFE SUPT4H1-1 HEXIM1 PPP3CA PPP3CC NFKB1 HDAC7 HDAC8 SUPT5H PPP3R1 NELFB HDAC4 RELA CDK9 NFATC1 NELFCD HDAC5 HDAC3 CELLULAR PROTEOSTASIS%WIKIPATHWAYS_20260510%WP4918%HOMO SAPIENS Cellular proteostasis PFDN6 PFDN4-1 VBP1 PFDN1 PFDN2 PFDN5 NSP1 FROM SARS COV 2 INHIBITS TRANSLATION INITIATION IN THE HOST CELL%WIKIPATHWAYS_20260510%WP5027%HOMO SAPIENS nsp1 from SARS CoV 2 inhibits translation initiation in the host cell EIF2S3;EIF2S3B EIF1 EIF3C;EIF3CL EIF5 EIF1AY;EIF1AX EIF3I EIF3J EIF3G EIF3E EIF3F EIF3D EIF2S2 EIF3A EIF3B EIF2S1 EIF3H DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260510%WP707%HOMO SAPIENS DNA damage response CHEK1 SESN1 CDC25C CCNE2 CCND1 MYC BRCA1 PRKDC CDK6 PMAIP1 CDK4 CCNB3 CCNB2 CCNB1 APAF1 BBC3 CASP8 TP53 BID RAD9A CDK2 MDM2-2 CDK1 ATR HUS1B PIDD1 SMC1A RRM2B TLK2 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A PML CASP9 CASP3 FANCD2 AKT1 DDB2 SFN TLK1 MRE11 ATRIP CREB1 RAD50 RAD51 E2F1 CYCS-1 RAD17 NBN RAD1 GADD45B GADD45A GADD45G CDK5 BAX CDKN1B RPA2 CDC25A RAD52 CCND3 CCNE1 FAS ABL1 RB1 ATM CCND2 RFC1 CHEK2 CDKN1A INTERACTOME OF POLYCOMB REPRESSIVE COMPLEX 2 PRC2 %WIKIPATHWAYS_20260510%WP2916%HOMO SAPIENS Interactome of polycomb repressive complex 2 PRC2 SUZ12 BCLAF1 EED MTF2 RBBP7 AEBP2 EZH1 MORC3 ELL SETX THRAP3 EZH2 STK38 TRIM35 JARID2 RBBP4 METHIONINE DE NOVO AND SALVAGE PATHWAY%WIKIPATHWAYS_20260510%WP3580%HOMO SAPIENS Methionine de novo and salvage pathway TXN ODC1 MAT2B SRM IL4I1 SMS MAT1A BHMT MAT2A MSRA CHDH MSRB2 MSRB3 AHCY TAT AMD1 APIP MRI1 MTAP ADI1 ENOPH1 MTR-1 FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20260510%WP357%HOMO SAPIENS Fatty acid biosynthesis ACAA2 ECHDC1 ECHDC2 ECHDC3 ACSL1 ACSL6 ACSL5 ACACA ECHS1 ACSL4 ACSL3 PECR SCD FASN DECR1 ACSS2 HADH ACACB ACLY PC MECR ECH1 INTERFERON TYPE I SIGNALING%WIKIPATHWAYS_20260510%WP585%HOMO SAPIENS Interferon type I signaling PRMT1 PIK3CD FYN RPTOR VAV1 RAPGEF1 PTPN6 IRS2 MLST8 IRS1 PDCD4 MAPKAP1 EIF4B STAT4 EIF4E PIAS1 MAP3K1 IFNAR2 ZAP70 MAP2K6 RPS6KA5 IFNAR1 RACK1 PTPRC MAP2K3 STAT2 RAP1A JAK1 STAT5A STAT1 RPS6 RPS6KB1 GAB2 STAT3 MTOR REL EIF4A1 CRKL RAC1 PIAS3 CRK TYK2 CBL PIK3R2 PIK3R1 EIF4EBP1 CREB1 IRF9 LCK SOCS3 PTPN11 SOCS1 RPS6KA4 MAPK14 NUCLEOSOME REMODELING COMPLEX%WIKIPATHWAYS_20260510%WP5572%HOMO SAPIENS Nucleosome remodeling complex PCNA XRCC5 H4C1 NASP-1 CHAF1A XRCC6 H4C6 SUPT16H NAP1L1 SMIM40 SSRP1 CHAF1B H4-16 PRKDC DAXX HAT1 ASF1A ASF1B IPO4 CHEK2 RBBP4 MCM2 SEROTONIN RECEPTOR 4 6 7 AND NR3C SIGNALING%WIKIPATHWAYS_20260510%WP734%HOMO SAPIENS Serotonin receptor 4 6 7 and NR3C signaling RPS6KA5 CREB1 ATF1 RAP1A HTR4 HTR6 SRF HTR7 ELK1 NR3C1 ELK4 MAP2K2;MAP2K1 EGR1 MAPK3 MAPKAPK2 MAPK1 BRAF GNAS-1 NF1 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260510%WP5366%HOMO SAPIENS NF1 copy number variation syndrome SUZ12 CCNE2 EED BCL2 ROCK2 MAP3K1 MAPK1 MCL1 RAF1 EXOC8 LIMK1 EXOC4 SOS1 EXOC3 EXOC6 EXOC5 IFNB1-4 EXOC2 RAD9A EXOC1 EIF3A ATR EGFR CCNA2-1 NGFR JARID2 PCNA MAVS H4C1 H4C6 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 DDX58 WDR48 H4-16 HOXA9 HOXA1 PRMT5 POLRMT MYT1 EZH1 EVL ATAD5-1 MAP3K2 SDC2 RNF135 ADAP2 INPP5A CFL1 EXOC7 E2F6 RAB11FIP4 RFC5 TEFM UTP6 RFC3 COPRS RFC4 EVI2A CRLF3 EVI2B USP1 METAP2 RHOA TUBB4A;TUBB;TUBB8B;TUBB8 NGF DNMT1 RAB11A RAD51 CRY1 SUPT5H EGF RBBP7 ARF6 NF1 SYN1 PER1 CCNE1 OMG MAPK3 RTN4R RFC2 SYNAPTIC VESICLE PATHWAY%WIKIPATHWAYS_20260510%WP2267%HOMO SAPIENS Synaptic vesicle pathway SLC17A6 SLC17A7 PARK7 SLC1A3 AP2A1 AP2A2 AP2B1 RAB3A SLC18A3 SLC25A4 AP2S1 AP2M1 SLC32A1 NAPA NSF SNAP25 UNC13A SYT1 STXBP1 SYP CPLX1 RIMS1 VAMP2 CLTCL1 CACNA1B CLTC CACNA1A CLTA SLC18A2 DNM3 DNM2 DNM1 SLC18A1 UNC13B UNC13C SYN3 SLC38A1 SYN2 SLC22A3 ATP1A2 CPLX2 CLN8 CPLX3 STX3 SLC17A8 STX2 STX1A SYN1 SLC6A4 DNM1L STRIATED MUSCLE CONTRACTION PATHWAY%WIKIPATHWAYS_20260510%WP383%HOMO SAPIENS Striated muscle contraction pathway MYL2 ACTG1 ACTC1;ACTG2 ACTN3 ACTN2 MYH6 ACTN4 DMD TPM2 MYL1 MYL3 TTN-1 TNNT1 TPM4 TPM1 ACTA2 TCAP TNNI1 MYOM1 TNNI2 TNNI3 MYBPC3 TMOD1 TNNC2 VIM MYBPC1 MYBPC2 MYL4 MYH3 NEB TNNT2 TNNT3 MYH8 ACTA1 TPM3 DES TNNC1 KYNURENINE PATHWAY AND LINKS TO CELL SENESCENCE%WIKIPATHWAYS_20260510%WP5044%HOMO SAPIENS Kynurenine pathway and links to cell senescence IFNG NOS1 HAAO IFNB1-4 ACMSD TLR4 TP53 TDO2 AFMID AADAT IDO2 IDO1 QPRT KLF5 KYNU KMO CAT TNF IL1R2 AHR EIF2AK1 FOXO1-1 EIF2AK4 CDKN1A PROLACTIN SIGNALING%WIKIPATHWAYS_20260510%WP2037%HOMO SAPIENS Prolactin signaling PTPN1 YWHAZ PIK3CB PIK3CG FYN SOCS2 VAV1 MYC PTPN6 IRS2 IRS1 NFKBIB JAK2 HRAS VAV2 NFKBIA JUN PIK3CA ERBB2 ZAP70 MAPK1 RAF1 NFKB1 SOS1 CTSD SRC JAK1 STAT5A PPIB STAT5B PRLR STAT1 RPS6 RPS6KB1 GAB2 STAT3 MTOR TEC GRB2 AGAP2 SHC1-1 GSK3B FLNA ELK1 RAC1 CASP3 AKT1 CISH PRL PIAS3 FOS CBL PXN PIK3R2 PIK3R1 EIF4EBP1 PAK1 ITGB1 SIRPA;SIRPB1;SIRPG SOCS3 RELA PTPN11 RPS6KA2 MAPK9 NEK3 MAPK8 PPIA MAP2K2;MAP2K1 SOCS1 MAPK3 MAPK14 YWHAG PTK2 VITAMIN B12 METABOLISM%WIKIPATHWAYS_20260510%WP1533%HOMO SAPIENS Vitamin B12 metabolism ICAM1 LDLR MPO F2 SERPINE1 CRP HBD;HBB HBA2;HBA1 NFKB2 INS;INS-IGF2 CUBN MTRR MMAB CBLIF NFKB1 MTR-1 TCN2 LRP2 TCN1 MMUT APOE ABCA1 TNF INSR SERPINA3 SAA2;SAA1 CBS;CBSL APOA1 FGB FGA SAA2-SAA4;SAA4 IL6 FGG F7 PLG ALB IL1B SHMT2 SOD2 CTH PLAT IFNG SOD3 RELA MTHFR MAT1A CCL13;CCL2 APOB MCEE CCL5 SOD1 SCARB1 TYROBP CAUSAL NETWORK IN MICROGLIA%WIKIPATHWAYS_20260510%WP3945%HOMO SAPIENS TYROBP causal network in microglia IGSF6 KCNE3 SAMSN1 HLX CYTL1 TCIRG1 PPP1R18;LOC107987457 LGALS9C;LGALS9;LGALS9B LHFPL2 GAPT TNFRSF1B ZFP36L2 GAL3ST4 MAF PLEK CREB3L2 RGS1 STAT5A ABCC4 SLC1A5 RPS6KA1 IL13RA1 DPYD IL18 GPX1 CAPG NCF2 PYCARD NCKAP1L ITGAM ITGB2 TYROBP ITGAX TGFBR1-1 ADAP2 IL10RA RUNX3 HCLS1 NPC2 SH2B3 LYL1 SPP1 C3-1 CD84 CD4 NRROS C1QC FKBP15 LOXL3 CD37 RNASE6 SLC7A7 APBB1IP BIN2 ELF4 SFT2D2 TMEM106A RBM47 VEGFA VEGFR2 SIGNALING%WIKIPATHWAYS_20260510%WP3888%HOMO SAPIENS VEGFA VEGFR2 signaling MYL2 ITGAV HLX FYN RPL7 NFATC2 LUC7L IER5 SND1 EWSR1 BIN1 PTPN6 TXNIP RPL27 ELOC-1 RPL26 PTPRZ1 ABCF2-H2BE1;ABCF2 GIGYF2 PRRC2C TRIP4 VAV2 LARP7 NFKBIA RPL5-1 BIRC5 GIPC1 FARSB KCNC3 SHB MAPK1 EEA1 PBK FHOD1 RAF1 RPLP2 ELOA NFKB1 CGNL1 AP2S1 MAP2K6 DUSP5 RPS6KA5 SSR4 SSR3 KANK1 CALR-1 SLC7A1 APOLD1 RACK1 FGD5 SLC8A1 TAOK2 CTNND1 PLOD3 GJA1 RPL10A SEMA6D ARMCX1 RAB37 MAPKAPK5 DSC1 LRRC59 STIP1 TXNDC5 FLII RAB4A BMX TFCP2 RCAN2 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A PRKCB TPP1 PRKCE BMP10 PRKCD NRARP PRKCA CAPZB ACP1 ADAMTS9 TRPC3 RPL13A-1 PBXIP1 DNAJB4 FLNB DNAJB9 ASCC3 SLC25A25 EPS15 PTPN14 TPCN2 MYO1C PRKD1 PTPN9 PRKRA TRAF3IP2 RPL18A CLTC UBAP2L CHAC1 ATP6V1E1 TMEM170A KATNAL2 ZNF555;ZNF57;ZNF556 SRF ATP6V0D1 EPB41 ADRB2 PRKCZ FXR2 DHX36 EGR3 SIAH2 MICAL2 STAM HDAC9 DHX29 RCAN1 SPIRE1 NRP2 MAPKAPK2 CCDC124 CLIC1 RHOJ FJX1 NEXN CRIP2 CCT7 TXN COPG1 CCRL2 TMOD3 PDIA6 DPM1 HGS PSMD11 IGFBP7 ARNT HTRA1 SCUBE2 ZC3H15 HERPUD1 NR4A3 GRSF1 C15orf39 RND1 LRRFIP2 YWHAE ARHGEF15 SHROOM2 EPN1 PPP2CB;PPP2CA RCN1 QKI MMRN2 USP10 FAM120A PDE4DIP ARRB2 FMNL3 DNAJA1-1 DKK1 ACOT9 BMP2 PLCB3 SELE ICAM1 CTNNA1 ATF2 FHL2 MEF2C PRKD2 SLC25A11 EGR1 JAG1 IGFBP3 LDB2 HDAC7 EPHB2 IDH2 PGD GLUD1;GLUD2 TKT TRPC1 GSK3B CXCL8 SDCBP ELK1 HSPA1A;HSPA1B AKT1 MAP3K5 HSP90AA1 PRKCI RHOA ERN1 CREB1 RAB11A CYCS-1 RAB5A PRKAA2 ACACA RELA PRDX6 RAP1B MAPK9 MAPK8 MAP2K2;MAP2K1 FAS PLCG1 HDAC5 MAPK3 CNP NOS3 MAPK14 PTK2 KL NR4A2 NR4A1 TEAD4 BCL2 FOXO4 CTNNB1 GRB10 TAL1 GATA2 HBD;HBB BSG JUN PIK3CA FSCN1 NOX4 ANXA1 ATF4 PLA2G4A DOK1 EIF4G1 GPX1 NCF1 NCF2 SARS1 CYBB SYNJ1 EPRS1 ARF6 TPM3 PGF NOTCH4 TNFRSF25 CDC42BPB F3 FLT1 ERG NDRG1 FBXW11 CCND1 RAPGEF1 MLST8 KDR PTK2B HRAS ETS1 FOXO1-1 AKT1S1 EPHA2 SRC MDM2-2 PLAU S1PR1 STAT3 MTOR LDHA GRB2 GAPDH-1 PGK1 ALDOA SHC1-1 LMAN1 SOD2 PPP1CA RAC1 PABPC1;PABPC3 DLL4 EIF4G2 CALU RHOC ENG VCL SHC2 FUT1 PIK3R2 PIK3R1 ADAM10 INPP5K PAK1 INPP4B ADAM9 PTPN11 CCL13;CCL2 DECR1 ABL1 MMP14 CDH5 CSRP2 ADAMTS1 PLAUR MYH11 MYH9 TMSB10 OCRL TFAM-1 MMP2 MKNK1 HDAC1 MYO6 ACKR3-2 FAF1 HMGB1-1 HDAC4 ITCH SMARCA2 GPC1 EIF2AK3 EIF3H PTGS2-2 AP2A1 CAV1 MAPK12 FADD BCL2L1 BRD4 FOXO3 CAPN2 STAT1 RPS6 RPS6KB1 NCK1 ARPC5L MAP2K4 PDPK1 TUBA1C GAB1 OCLN-1 CRK HBEGF NCL-1 CBL TUBB4A;TUBB;TUBB8B;TUBB8 MAP2K7 CCN2 PAK2 ITGB1 SRPK1 TNXB PRDX2 SRP54 ARF4-1 RPS11 AFDN NUMB VPS39 PRKAA1 MAPKAP1 CREBBP RICTOR PPM1G EIF4E VEGFA ACACB ATF6 RBM39 SDF2L1 CCN1 TBCA CACNA2D1 HYOU1 MAP2K3 AMOT CSRP1 SH3BGRL3 MOV10 PTPRJ SET-1 PNP-1 WASF1-1 PSMD4 PTMA ACTG1 CFL1 PFN1 EZR PXN IQGAP1 FN1 PTPN1 EIF2A MMP10 ROCK1 ROCK2 CDC42 CSK LIMK1 NAPA BCAR1 EIF3F RAP1A EIF3D P4HA2 P4HB ITGB5 FGB FGA FGG NAP1L1 HSPB1 ALB PPP3CA CAMKK2 TMOD1 STAT6 FRS2 NFATC1 PRKG1 PLA2G5 ITGB3 BENZO A PYRENE METABOLISM%WIKIPATHWAYS_20260510%WP696%HOMO SAPIENS Benzo a pyrene metabolism CYP1A1 AKR1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 EPHX1 CYP1B1 WNT BETA CATENIN SIGNALING IN LEUKEMIA%WIKIPATHWAYS_20260510%WP3658%HOMO SAPIENS Wnt beta catenin signaling in leukemia FLT3 CCND1 WIF1 SALL4 CTNNB1 MYC GSK3B AKT1 AXIN2 PYGO1 RARA PPARD LEF1 LRP5 LRP6 WNT1 RUNX1T1 CSNK1A1 ZBTB16 FZD6 DKK1 JUP PML BCL9 APC NEUROTRANSMITTER DISORDERS%WIKIPATHWAYS_20260510%WP4220%HOMO SAPIENS Neurotransmitter disorders TPH1 TH MAOA TPH2 COMT SLC18A2 SLC6A3 DBH DDC PNMT FAS LIGAND PATHWAY AND STRESS INDUCTION OF HEAT SHOCK PROTEINS%WIKIPATHWAYS_20260510%WP314%HOMO SAPIENS Fas ligand pathway and stress induction of heat shock proteins HSPB1 CASP6 BCL2 ACTG1 DFFB DFFA CASP10 PRKDC MAP2K4 FAF1 CASP9 LMNA DAXX CASP3 JUN MAP3K1 MAPKAPK3 MAPKAPK2 PARP1 APAF1 FASLG ARHGDIB CASP7 CASP8 PAK1 FADD PAK2 RIPK2 IL1A CYCS-1 SMIM40 LMNB2 MAP3K7 SPTAN1 MAPK8 ACTA1 FAS TNF RB1 LMNB1 NFX1 ACTB-1 CFLAR METHYLATION PATHWAYS%WIKIPATHWAYS_20260510%WP704%HOMO SAPIENS Methylation pathways COMT MAT2B INMT MAT1A HNMT NNMT TPMT PNMT MAT2A QUERCETIN AND NF KB AP 1 INDUCED APOPTOSIS%WIKIPATHWAYS_20260510%WP2435%HOMO SAPIENS Quercetin and Nf kB AP 1 induced apoptosis MAFG NOS1 KEAP1 MAFK PTGS2-2 MMP1 IKBKB NFKBIA JUN VEGFA NFE2L2 ACOX2 CYP2A13;CYP2A6;CYP2A7-1 FOS NFKB1 MAPK CASCADE%WIKIPATHWAYS_20260510%WP422%HOMO SAPIENS MAPK cascade KRAS GRB2 PLCB3 ARAF ELK1 MAP3K2 MAP2K4 MAP3K3 HRAS RASA3 MAP2 JUN MAP3K1 RRAS MAPK1 RAF1 MAPK12 MAP2K6 NRAS MAP2K7 SOS1 LAMTOR3 SOS2 MAP2K3 MBP MAPK10 MAP2K2;MAP2K1 MAPK3 SIPA1 MAP3K12 BRAF MAPK14 SUZETRIGINE MECHANISM FOR PAIN RELIEF%WIKIPATHWAYS_20260510%WP5558%HOMO SAPIENS Suzetrigine mechanism for pain relief SCN10A VITAMIN B6 DEPENDENT AND RESPONSIVE DISORDERS%WIKIPATHWAYS_20260510%WP4228%HOMO SAPIENS Vitamin B6 dependent and responsive disorders ALPL PDXK PLPBP PIGV ALPG;ALPP;ALPI-1 PNPO ALDH7A1 G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20260510%WP45%HOMO SAPIENS G1 to S cell cycle control PRIM2 CCNE2 CCND1 CDKN2A MYC MNAT1 CDK6 CDK4 ORC5 POLA2 ORC4 CCNB1 ORC6 ORC1 ORC3 ORC2 TP53 ATF6B CDK7 CREB3L3 CREB3L4 CDK2 CREB3L1 MDM2-2 CDK1 CDKN1C MCM7 CREB3 CCNA1 TFDP1 TFDP2 MCM3 MCM4 MCM5 MCM6 MCM2 PCNA CDC45 CDKN2D CDKN2B CDKN2C WEE1 MYT1 POLE CREB1 PRIM1 E2F1 E2F2 E2F3 GADD45A RPA1 CDKN1B RPA2 CDC25A CCND3 CCNE1 RB1 ATM CCNH RPA3 POLE2 CCND2 CDKN1A CCNG2 HALLMARK OF CANCER NON MUTATIONAL EPIGENETIC REPROGRAMMING%WIKIPATHWAYS_20260510%WP5483%HOMO SAPIENS Hallmark of cancer non mutational epigenetic reprogramming HDAC2 YTHDF3 CADM1 EP300 HDAC1 TET2 FTO DNMT1 NOL9 DNMT3A IRS1 CREBBP EZH2 PIP4K2A ANKRD13C IFITM3;IFITM2;IFITM1 GGT6 EICOSANOID METABOLISM VIA CYCLOOXYGENASES COX %WIKIPATHWAYS_20260510%WP4719%HOMO SAPIENS Eicosanoid metabolism via cyclooxygenases COX ACOX3 PTGDR2 ACOX1 PTGS2-2 PTGS1 PLA2G6 TBXAS1 PRXL2B PPARG PPARD PTGFR AKR1B1 PTGIR PTGIS HPGD TBXA2R PLA2G4A EHHADH-1 PTGR1-1 PTGES PLA2G5 PTGDS ACAA1-1 ACOX2 CYP4F3;CYP4F2;CYP4F12;CYP4F11 PTGR2 PTGDR JMJD7-PLA2G4B;PLA2G4B OLIGODENDROCYTE DEVELOPMENT%WIKIPATHWAYS_20260510%WP5574%HOMO SAPIENS Oligodendrocyte development SOX2 CHD8 CSPG4 PTN SOX8 ZNF24 DUSP15 RELN NFATC2 FGF2 ZNF488 LGI1 SOX11 EGR2 NKX2-6 OPALIN OLIG1 ZBTB33 MYT1 TCF7L2 ID4 PTPRZ1 CNTN1 SOX5 PDGFRA NFIA SOX6 SOX9 MYRF CHD7 WNT10A MBP OLIG2 SOX10 BMP1 TMEM98 ASCL1 HES5 SHH ID2-1 SMAD1 BMP4 ZEB2 NKX6-1 MAG NKX2-2 PRKCA GLI2 13Q12 12 COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5406%HOMO SAPIENS 13q12 12 copy number variation TRAF1 FLNC TRAF3 SGCD SGCA SGCB SGCG MIPEP C1QTNF9B;C1QTNF9 ATXN1 RAC1 SACS DMD DTNA TNFRSF19 DAG1 SPATA13 SSPN RTN4 CDC42 SNTB1 SNTA1 TRAF2 TRAF5 ADIPOQ RHOA MAPK9 MAPK8 MAG RTN4R LINGO1 CHOLESTEROL BIOSYNTHESIS WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260510%WP4804%HOMO SAPIENS Cholesterol biosynthesis with skeletal dysplasias DHCR24 NSDHL EBP LBR CYP51A1 SC5D DHCR7 FELBAMATE METABOLISM%WIKIPATHWAYS_20260510%WP2816%HOMO SAPIENS Felbamate metabolism CYP2E1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 OSTEOBLAST DIFFERENTIATION AND RELATED DISEASES%WIKIPATHWAYS_20260510%WP4787%HOMO SAPIENS Osteoblast differentiation and related diseases PTCH1 CTNNB1 NOTCH2 NOTCH1 PRKDC SMO PIK3CA MAPK1 SMAD4 HES6 HES3 PRKCG PRKCH PRKCB PRKCE PRKCD PRKCA PRKCQ PRKD1 FGF2 FGF3 FGF4 FGF5 FGF6 FGF7 PRKCZ FGF8 FGF9 MYOD1 HEY2 MAPK13 SMAD1 NOTCH3 SMAD9 NOTCH4 SMAD5 FGF18 BMP2 WNT4 FGF10 PIK3CD PIK3CB PIK3CG PIK3C3 PIK3R4 PIK3C2G PIK3C2A PIK3R6 JAG1 PIK3C2B PIK3R5 HES2 MAPK6 PPARG MAPK4 MAPK12 MAPK11 BMPR1B BMPR1A BMPR2 LRP5 LRP6 WNT1 STAT1 FZD6 FGFR4 FGFR3 FGFR2 FGFR1 JAG2 DLL1 WNT2B FZD10 DLL3 DLL4 WNT5B WNT9B WNT9A WNT16 PRKCI PIK3R3 WNT8A PIK3R2 WNT8B PIK3R1 WNT6 SOX9 WNT11 WNT2 WNT3 WNT10B WNT10A RBPJ FZD3 FZD2 MAPK10 FZD5 FZD4 WNT3A WNT7B FZD7 FGF1 FZD9 MAPK9 WNT7A FZD8 MAPK8 FZD1 WNT5A RUNX2 MAPK7 MAPK3 BMP4 GLI3 IHH GLI2 MAPK14 HEY1 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES MAPK SIGNALING%WIKIPATHWAYS_20260510%WP4877%HOMO SAPIENS Host pathogen interaction of human coronaviruses MAPK signaling MAP3K9 ATF2 BCL2 DDIT3 MAP2K4 EIF4E JUN MAP3K1 MAP3K11 JUNB MAPK1 RAF1 FOS MAPK12 IFITM3;IFITM2;IFITM1 MAP2K6 MAPK11 MAP2K7 MAP2K3 MAP3K4 MAPK10 MAP3K10 RPS6KA2 MAPK9 MAPK8 MAP2K2;MAP2K1 MAPK13 RPS6KA3 RPS6KA1 MAPK3 BST2 MAPK14 SPHINGOLIPID METABOLISM OVERVIEW%WIKIPATHWAYS_20260510%WP4725%HOMO SAPIENS Sphingolipid metabolism overview CERS1 CERS2 SGPL1 SPTLC1 SMPD1 SPHK2 SGPP2 SGPP1 DEGS1 DEGS2 PLPP3 PLPP2 PLPP1 GBA GBA2 CERS3 CERS4 ASAH1 CERS6 CERK SGMS1 SPHK1 SGMS2 UGT8 UGCG KDSR HIPK2 IN KIDNEY FIBROSIS%WIKIPATHWAYS_20260510%WP4751%HOMO SAPIENS HIPK2 in kidney fibrosis HIPK2 SIAH1 MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20260510%WP391%HOMO SAPIENS Mitochondrial gene expression CREB1 PPARGC1A SP1 HCFC1 NRF1 POLRMT CAMK4 MYEF2 TFB1M TFB2M PPRC1 ESRRA TFAM-1 MTERF3 PPP3CA PPARGC1B MTERF1-1 GABPB1 GABPA INFLAMMATORY BOWEL DISEASE SIGNALING%WIKIPATHWAYS_20260510%WP5198%HOMO SAPIENS Inflammatory bowel disease signaling IL2 IL6 IL13 IL21 IL22 IL23R RORC RORA STAT4 IL12RB1 JUN IL4R IFNGR1 NFKB1 SMAD2;SMAD3 IL12A FOXP3 IL12RB2 IFNG IL23A TLR5 NOD2 IL18RAP IL5 IL1A MAF TLR4 TLR2 GATA3 HLA-DMA IL2RG TBX21 IL21R STAT6 NFATC1 STAT1 IL4 TNF IL17F IL10 TGFB1 STAT3 IL18 GROWTH FACTORS AND HORMONES IN BETA CELL PROLIFERATION%WIKIPATHWAYS_20260510%WP5385%HOMO SAPIENS Growth factors and hormones in beta cell proliferation FLT1 KRAS IGF1R IGF1 FOXM1 MYC AKT2 AKT3 CDK4 TGFBR1-1 AKT1 INS;INS-IGF2 FOXO1-1 MAPK1 SMAD7 DLK1 CDK2 PDGFA MAPK3 PGF INSR RASSF1 CRTC2 PDX1 BRAF ALZHEIMER 39 S DISEASE AND MIRNA EFFECTS%WIKIPATHWAYS_20260510%WP2059%HOMO SAPIENS Alzheimer 39 s disease and miRNA effects DVL1 DVL2 MCU DVL3 MME AXIN1 IKBKB TPTEP2-CSNK1E;CSNK1E CHUK MAPK1 RAF1 NOS2 NFKB1 KIF5A PSEN2 XBP1 SLC25A5 ATG13 APOE ULK1 HSD17B10 ATG101 NOS1 KIF5C KIF5B ITPR1 ITPR2 CACNA1D ITPR3 CACNA1C RB1CC1 CACNA1F CACNA1S BECN1 GNAQ APBB1 APH1B CALM1 CALM2 AMBRA1 ATP2A3 ATP2A2 PSMA4 DKK1 EIF2AK3 RYR3 WNT4 PLCB3 GRIN2C PTGS2-2 IRS1 PIK3R4 INS;INS-IGF2 APAF1 SLC25A4 CASP7 CASP8 FADD BID CALM3;CALM1 CAPN2 CAPN1 DKK4 TNF MAPT IL6 NOX1 GSK3B TUBAL3 CASP9 TUBA1C TUBA1A WIPI1 TUBB1 CASP3 WIPI2 AKT1 TUBA3E;TUBA3C-1 ATG14 TUBB2B;TUBB2A MAP3K5 TUBB4B TUBA4A EIF2AK2 ATG2A TUBB4A;TUBB;TUBB8B;TUBB8 ERN1 MAP2K7 TUBB3;TUBB6 TUBA8 CYCS-1 PSEN1 MAPK10 RELA EIF2S1 CDK5 MAPK9 MAPK8 FZD1 MAP2K2;MAP2K1 WNT5A CSNK2A1;CSNK2A3 FAS MAPK3 BRAF CDK5R1 CTNNB1 DDIT3 PLCB1 PPIF PIK3CA RTN4 TRAF2 ATF6 NOX4 PLCB2 ATF4 SNCA PSMD9 PSMD6 PSMD4 PSMD3 PSMD1 PSMC2-1 VDAC3 NRBF2 CYBB ATG2B IDE PSMA5 PSMA6 PSMA3 PSMA1 PSMA7 PSMA8 VDAC1 PSMB6 PSMB7 CSF1 PSMB4 PSMB5 PSMB2 PSMB3 PPP3CC PSMB1 PSMA2-1 PSMC5 PSMC3 PSMC1 VDAC2-1 PPID RTN3 PSMD14 SEM1 IL1A GPR83 KLC1 KLC4 TNFRSF1A KLC3 KLC2 NAE1 ATP2A1 SLC25A6 PSENEN BECN2 ADRM1 SLC25A31 APH1A NCSTN CHRNA7;CHRFAM7A IRS4 LRP1 LPL PSMD8 FRAT2 PSMD7 PIK3CD PIK3CB PSMD2 APC2 AKT2 AKT3 IRS2 PIK3C3 HRAS AGER AXIN2 ULK2 GRIN2D LRP5 LRP6 WNT1 GRIN2B GRIN1 CSNK1A1 CSNK2A2 INSR PSMC6 DKK2 PSMC4 FZD6 MTOR CSNK2B APC PSMD12 KRAS PSMD13 GAPDH-1 IL1B CALML6 ARAF CALML3 CALML4 WNT2B APP FZD10 WNT5B PPP3CB WNT16 PPP3CA SFRP4 PIK3R3 PIK3R2 PIK3R1 ADAM10 WNT6 GRIN2A WNT11 NRAS WNT2 WNT3 WNT10B BACE1 PPP3R1 WNT10A ADAM17 FZD3 FZD2 FZD5 PLCB4 BAD WNT3A WNT7B FZD7 FZD9 WNT7A FZD8 NAD METABOLISM SIRTUINS AND AGING%WIKIPATHWAYS_20260510%WP3630%HOMO SAPIENS NAD metabolism sirtuins and aging SIRT3 NAMPT HIF1A FOXO1-1 TFAM-1 FOXO3 ROS1 PARP1 PPARG NFKB1 SIRT1 3Q29 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP4906%HOMO SAPIENS 3q29 copy number variation syndrome NCBP1 MYC NF2 JUN DYNC2I2 DYNC2I1 CEP19 PIGZ SENP5 TFRC UBXN7 DLG1 CASP7 MAD2L1BP-1 SMCO1 MYCBP2 FBXO45 NCBP2-1 DYNC2H1 GRIA1 BRINP1 TF TM4SF19 CEP350 PCYT1A MCRS1 WDR53 ZNF76 MELTF STAT5A STAT5B H2BC21 SLC51A DYNC2LI1 SLC51B PIGX-1 SLC40A1 PIGM RNF168-1 RNF8 HFE FNDC8 SIRT1 HAMP DYNLRB2 DYNLRB1 UBE2N DYNLT1 PIK3R3 PXN ADAM10 FBXW7 PAK2 HIF1A DYNLT2B NRROS RABL2A;RABL2B TGFB1 CEP43 CYTOPLASMIC RIBOSOMAL PROTEINS%WIKIPATHWAYS_20260510%WP477%HOMO SAPIENS Cytoplasmic ribosomal proteins RPS17 RPS16 RPS19 RPS18 RPS11 RPS10 RPL7 RPS13 RPS12 RPS9 RPS7 RPL27 RPS8 RPL26 RPS5 RPSA RPL5-1 RPLP2 RPS29 RPS20 RPS21 RPS24 RPL10A RPS23 RPL4 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPS6 RPL8 RPS6KB1 RPL9 RPS6KB2 RPL6 RPS4X RPS6KA3 RPS6KA1 RPL30 RPL7A RPS15A RPL37A-1 RPS3 RPL35 RPL38 RPL11 RPS2 RPL36-1 RPS27A RPL39 RPL15-1 RPL21 RPL13A-1 RPL22 RPS3A RPL24 RPL29 RPL23 UBA52 FAU RPL28 RPL10;RPL10L-1 MRPL19 RPL14 RPL18A RPL13 RPL12-1 RPL18 RPL17 RPL19 RPL35A RPL23A RPL3L RPS25 RPS27 RPL27A RPS6KA6 RPS6KA2 RPS15 RPS14 FOCAL ADHESION%WIKIPATHWAYS_20260510%WP306%HOMO SAPIENS Focal adhesion MYL2 VEGFC ITGAV FYN ACTN4 VAV2 COL4A2 PARVA BIRC3 FGR MAPK1 RAF1 ITGA5 TLN1 MYLPF PRKCG PRKCB CAV3 CAV2 PRKCA THBS1 FLNB FLNC FLNA RASGRF1 MYLK3 ILK TESK2 ITGA10 TNK2 ITGA2 ITGB7 RELN ERBB2 CAV1 TNC MYLK2 CAPN2 VASP LAMC1 ZYX VTN ITGA3 BUB1B-PAK6;PAK6 ITGA6 CRKL GSK3B ELK1 PDPK1 MYL5 MYL7 AKT1 TLN2 TXK MYL12A MYL10 SRMS CRK PTK6 PARVB SHC4 PARVG SHC3 ARHGAP5 EMP2 RHOA MYLK4 IBSP COMP TNN TNR XIAP PAK3 BLK PAK2 CHAD TNK1 COL2A1 PAK4 COL5A3 COL5A2 EGF COL6A2 MAPK10 ITGB1 PPP1R12B PPP1R12C LAMA5 THBS4 SPP1 THBS3 PDGFA STYK1 TNXB RAP1B MAPK9 COL1A1 MAPK8 MAP2K2;MAP2K1 MAPK3 BRAF PTK2 BCL2 CTNNB1 BIRC2 PPP1CB HCK JUN VEGFA PIK3CA ITGB4 VAV3 ARHGAP35 MYLK ACTG1 MYL12B ACTN1 PXN PDGFB PIP5K1C FN1 ITGA2B PGF DIAPH1 THBS2 ACTB-1 FLT1 HGF PTEN RAC3 PIK3CD PIK3CB IGF1R PPP1R12A ITGA1 CCND1 VAV1 RAPGEF1 AKT2 AKT3 KDR VEGFD DOCK1 HRAS PDGFRB ROCK1 PDGFRA ROCK2 COL4A1 COL4A4 CDC42 COL4A6 LAMC3 SOS1 LAMC2 MET BCAR1 COL1A2 LAMA2 SRC RAP1A LAMA1 LAMA4 LAMA3 EGFR LAMB3 LAMB2 LAMB1 PPP1CC ITGA11 ITGB5 ITGB8 ITGA8 ITGA7 ITGA9 GRB2 VWF SHC1-1 IGF1 PPP1CA RAC1 ITGB6 VCL SHC2 PIK3R3 PIK3R2 PIK3R1 PAK1 BAD PDGFD PDGFC VEGFB CCND3 ITGA4 ITGB3 CCND2 OLIGODENDROCYTE SPECIFICATION AND DIFFERENTIATION LEADING TO MYELIN COMPONENTS FOR CNS%WIKIPATHWAYS_20260510%WP4304%HOMO SAPIENS Oligodendrocyte specification and differentiation leading to myelin components for CNS SOX8 FGF2 IGF1 IL1B NKX2-6 OLIG1 MYT1 SOX5 SOX6 CXCL2;CXCL3;CXCL1-1 LIF PDGFB SOX9 PLP1 MBP MOG OLIG2 SOX10 ASCL1 SHH TNF OMG CNTF BMP4 MAG CNP NKX2-2 GLI2 BMP2 OSX AND MIRNAS IN TOOTH DEVELOPMENT%WIKIPATHWAYS_20260510%WP3971%HOMO SAPIENS OSX and miRNAs in tooth development BMP7 KLF4 SOST DMP1 ALPL CTNNB1 NOTCH2 DSPP SP7 NOTCH1 HNF1A RUNX2 NOTCH3 DKK1 NOTCH4 4P16 3 COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5365%HOMO SAPIENS 4p16 3 copy number variation GRB2 H3-3A FGFR3 FGF2 GAB1 NELFA NELFE MAPK1 CBL PIK3R1 POLN SOS1 NELFB ERI1 NAT8L SLBP NSD2 FRS2 TMEM129 FAM53A CKAP5 LETM1 CLTCL1 NELFCD PLCG1 TACC3 MAPK3 C4orf48 UBE2J2 BCS1L LIPID METABOLISM PATHWAY%WIKIPATHWAYS_20260510%WP3965%HOMO SAPIENS Lipid metabolism pathway PRKAR1B PRKAR1A BCKDHA AKT2 PRKAA1 AKT3 FASN AKT1 PRKAR2B PDHA1 PRKAR2A PRKACB-1 ABHD5 ACLY ACSBG1 PRKAB2 PRKAB1 PRKAA2 ACACA LIPE PRKAG1 PRKAG2 PRKAG3 ACSS2 PLIN1 PRKACA-1 PNPLA2 MIRNA REGULATION OF DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260510%WP1530%HOMO SAPIENS miRNA regulation of DNA damage response CHEK1 SESN1 CDC25C CCNE2 CCND1 MYC BRCA1 PRKDC CDK6 PMAIP1 CDK4 CCNG1 CCNB3 CCNB2 CCNB1 APAF1 BBC3 CASP8 TP53 BID RAD9A CDK2 MDM2-2 CDK1 ATR HUS1B PIDD1 SMC1A RRM2B TLK2 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A PML CASP9 CASP3 FANCD2 DDB2 SFN TLK1 MRE11 ATRIP CREB1 RAD50 RAD51 E2F1 CYCS-1 RAD17 NBN RAD1 GADD45B GADD45A GADD45G CDK5 BAX CDKN1B RPA2 CDC25A RAD52 CCND3 CCNE1 FAS ABL1 RB1 ATM CCND2 RFC1 CHEK2 CDKN1A INTERACTIONS BETWEEN IMMUNE CELLS AND MICRORNAS IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260510%WP4559%HOMO SAPIENS Interactions between immune cells and microRNAs in tumor microenvironment CXCL10 CD274 CTLA4 IL2RB TGFBR2 TLR7 CD80 PDCD1 IRAK4 NFKB2 PIAS3 TRAF6 IL4R NFKB1 TGFB2 TGFB3 TLR4 IL2RG CCL13;CCL2 STAT6 IL4 TLR8 CCL5 SOCS1 IL2RA TGFB1 CD86 STAT3 VITAMIN D SENSITIVE CALCIUM SIGNALING IN DEPRESSION%WIKIPATHWAYS_20260510%WP4698%HOMO SAPIENS Vitamin D sensitive calcium signaling in depression RXRA CYP27B1 GRIN2C ITPR1 G6PD BCL2 ITPR2 ITPR3 CACNA1C TPH1 GSR NFE2L2 KDM1A GCLC KDM6B GRIN2A CHRM1 GGT1 TPH2 VDR SLC8A1 ATP2B3 ATP2B2 GRIN2D GRM5 ATP2B1 KCNQ2 KCNQ3 GRIN2B GRIN1 KDM1B CALB1 ATP2B4 CYP27A1 KDM3A PVALB APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20260510%WP384%HOMO SAPIENS Apoptosis modulation by HSP70 CASP7 CASP8 RIPK1 FADD BID CYCS-1 TNFRSF1A MAPK10 CASP6 CASP2 CASP9 HSPA1A;HSPA1B CASP3 FAS MAP3K1 AIFM1 APAF1 FASLG NFKB1 METABOLIC PATHWAYS OF FIBROBLASTS%WIKIPATHWAYS_20260510%WP5312%HOMO SAPIENS Metabolic pathways of fibroblasts LDHA UGP2 GLUD1;GLUD2 FGFR4 PGM1 FGFR1 ALDH18A1 PSAT1 PHGDH PSPH SLC16A1 CD36 PLOD1 ADAMTS2 SERPINH1 RHOA BMP1 P4HA1 P4HA2 GCK LPAR1 SLC1A5 PLCG1 GLS LOXL2 UGDH GPI P3H4 P3H3 SLC2A1 PYCR1 P4HA3 THYROID HORMONES PRODUCTION AND PERIPHERAL DOWNSTREAM SIGNALING EFFECTS%WIKIPATHWAYS_20260510%WP4746%HOMO SAPIENS Thyroid hormones production and peripheral downstream signaling effects TTF1 THRB NHSL1 ITGAV IYD POMC DUOXA2 SECISBP2L ADRB3 DUOX2 TG SLC26A4 RPTOR ACTL6B ATF2 CTNNB1 AKT3 MLST8 NOTCH1 ADCY3 HRAS ADCY8 TSC2 TSC1 PIK3CA PRDM16 FOXO1-1 MAPK1 KDM1A RAF1 PPARG AKT1S1 NPPB SOS1 TP53 PPARGC1A SRC MDM2-2 CREB3 RPS6 TPO RPS6KB1 MTOR SIRT6 RHEB GRB2 RXRA DIO1 SLCO1C1 TBC1D4 DIO3 FGFR1 ITPR2 GSK3B SLC16A10 SLC16A2 PFKFB2 CASP9 TSHB MAFA MAPKAPK3 TSHR LOC100509620;LOC112267859;AQP7 BAD KLB SLC5A5 FGF21 RPS6KA6 MC4R SHH NPY FRS2 PAX8 AGRP MAP2K2;MAP2K1 NPR1 PRKG2 ZNF516 PLIN1 MGLL THRA KDM3B ITGB3 PRKACA-1 UCP1 MAPK14 TRH TTF2 MAP4K5 WNT4 PNPLA2 PROSTAGLANDIN AND LEUKOTRIENE METABOLISM IN SENESCENCE %WIKIPATHWAYS_20260510%WP5122%HOMO SAPIENS Prostaglandin and leukotriene metabolism in senescence KRAS ALOX15 ALOX12 PTGS2-2 PTGS1 SIRT1 TBXAS1 ADCY3 HRAS GNAI1 PRXL2B MAPK11 NRAS GNAQ IGFBP5 TP53 PTGER4 PTGER1 PTGER2 PTGER3 PTGIS LTC4S RB1 PLA2G4A ALOX5AP CYSLTR1 LTA4H ALOX5 PTGES PTGDS GNAS-1 ALOX15B CDKN1A SRF AND MIRS IN SMOOTH MUSCLE DIFFERENTIATION AND PROLIFERATION%WIKIPATHWAYS_20260510%WP1991%HOMO SAPIENS SRF and miRs in smooth muscle differentiation and proliferation MEF2D ELK1 KLF4 MEF2A MYOCD NKX2-5 CAMK2D CCND2 MEF2C SRF MEF2B;BORCS8-MEF2B FAMILIAL HYPERLIPIDEMIA TYPE 2%WIKIPATHWAYS_20260510%WP5109%HOMO SAPIENS Familial hyperlipidemia type 2 LPL LCAT APOA4 LIPC LDLR PLTP USF1 GPIHBP1 APOB PCSK9 GHR LDLRAP1 APOA2 EPHX2 APOA1 CETP CAFFEINE AND THEOBROMINE METABOLISM%WIKIPATHWAYS_20260510%WP3633%HOMO SAPIENS Caffeine and theobromine metabolism CYP1A2 XDH CYP2A13;CYP2A6;CYP2A7-1 BLOOD BASED NEUROINFLAMMATION MARKERS %WIKIPATHWAYS_20260510%WP5548%HOMO SAPIENS Blood based neuroinflammation markers GFAP CHI3L1 IL6 TREM2 TREM1 IL1B GRN BDNF ADM CX3CL1 OLR1 CCL13;CCL2 CRP CCL23;CCL15 TAC1 CCL5 TNF NEFL TSPO CCL11 TRANSCRIPTIONAL CASCADE REGULATING ADIPOGENESIS%WIKIPATHWAYS_20260510%WP4211%HOMO SAPIENS Transcriptional cascade regulating adipogenesis CEBPA CEBPD GATA3 CEBPB EGR2 KLF15 DDIT3 KLF2 KLF5 SREBF1 CEBPG GATA2 PPARG ALSTROM SYNDROME%WIKIPATHWAYS_20260510%WP5202%HOMO SAPIENS Alstrom syndrome IFT27 PTCH1 E2F4-1 BLOC1S4 VCPIP1 BLOC1S6 HSPB11 BLOC1S1 SMO STX5 SNAPIN ACTN4 PIFO RFX2 DTNBP1 DNM3 RFX3 RFX1 TUBG1 ARMCX5-GPRASP2;GPRASP2 NSFL1C RILPL1 CEP19 MYO5B IFT172 ALMS1 VCP-1 GPR161 IFT81 IFT74 RABL2A;RABL2B TFDP2 CEP192 LIDOCAINE METABOLISM%WIKIPATHWAYS_20260510%WP2646%HOMO SAPIENS Lidocaine metabolism CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 FERROPTOSIS%WIKIPATHWAYS_20260510%WP4313%HOMO SAPIENS Ferroptosis GPX4 SLC39A14 ALOX15 ACSL1 ACSL4 ACSL3 ATG7 GCH1 NCOA4 GSS BACH1 GCLC TFRC SAT2 POR GCLM CHMP6 AIFM2 CHMP5 DPP4 TP53 FTMT TF PCBP1 LPCAT3 ACSL6 NOX4 ACSL5 CISD1 SLC1A5 FDFT1 MAP1LC3B2;MAP1LC3B-1 HMGCR PHKG2 CBS;CBSL SLC3A2 SLC7A11 IREB2 SLC40A1 HMOX1 TXNRD1 HSPB1 NOX1 VDAC3 CYBB MAP1LC3A ATG5 CTH FTL-1 SAT1 STEAP3 FTH1 SLC39A8 CP MAP1LC3C PCBP2 PRNP SLC11A2 VDAC2-1 SLC38A1 COQ2 KREBS CYCLE DISORDERS%WIKIPATHWAYS_20260510%WP4236%HOMO SAPIENS Krebs cycle disorders DHTKD1 LDHA MPC1 PDHX SUCLA2 SUCLG1 LDHA;LDHC FH LDHB DLST PCK2 GPT SUCLG2 VALPROIC ACID PATHWAY%WIKIPATHWAYS_20260510%WP3871%HOMO SAPIENS Valproic acid pathway CYP2C9;CYP2C19 CYP2B6 HDAC1 HADHA HADHB-1 HSD17B10 EHHADH-1 ACSM1 IVD CYP2A13;CYP2A6;CYP2A7-1 ABAT ACADSB INTEGRATED BREAST CANCER PATHWAY%WIKIPATHWAYS_20260510%WP1984%HOMO SAPIENS Integrated breast cancer pathway CHEK1 EP300 FOSL2 ODC1 FOSL1 STK11 TAB1 CDC25B TGFBR2 SP1 BCL2 GRN CTNNB1 GDI1 TRADD SMARCA4 BRCA1 MMP1 CDK4 CSNK1D JUN VEGFA DAG1 RRAS ESR1 CHUK MAPK1 BACH1 NFKB1 SMAD2;SMAD3 DHTKD1 SMAD4 PLK1 ATF1 CDK7 CDK2 ATR NAB1 MAP3K7CL ZMYND8-1 RHO ALKBH1 RPP38 ANXA1 RALGAPA1 PPP4R3A PPP4R3B CCNB1IP1 NUP85 PLK3 XRCC3 SELENOK FER PIGR USP38 HMGCR IMPA1 RASGEF1A DCAKD ITPKC USP15 USP16 HDAC1 AURKA FAU RAD54L USP21 FILIP1 UBE2F WEE1 MRE11 MSH6 BRCA2 RAD50 PKIA RAD51 BARD1 CERK SMAD1 MAX MAP3K13 ZNF655 AR TPR MSH2 BLM PTEN NOXA1 CCND1 MYC ZMIZ1 IRS1 NCOA3 CYP19A1 RALA-1 PIAS1 TSC2 TSC1 FOXO1-1 CDC42 RASGRP3 ERAL1 CASP8 MYCBP2 FADD TP53 BID GSK3A MDM2-2 RAP1A BMPR1A JAK1 JAKMIP1 BMPR2 EGFR STAT1 PHB MTOR PML HIPK2 RHEB KRAS ARAF TFPI MYT1 SIRT1 CASP9 CDH1 TGFBR1-1 RAC1 CASP3 AKT1 AHR PIK3R2 SMAD6 SMAD7 CREB1 PAK1 E2F1 BAK1 BAD GADD45A NF1 BAX CDC25A ABL1 RB1 ATM EDAR BRAF CHEK2 MITOCHONDRIAL COMPLEX III ASSEMBLY%WIKIPATHWAYS_20260510%WP4921%HOMO SAPIENS Mitochondrial complex III assembly UQCRB UQCC3 UQCC2 UQCC1 UQCR11 UQCR10 TTC19 UQCRQ LYRM7 UQCRC1 CYC1 UQCRC2 UQCRFS1 BCS1L SOX GENES AND THEIR INFLUENCE ON NEUROGENESIS AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260510%WP5568%HOMO SAPIENS SOX genes and their influence on neurogenesis and neurodevelopmental disorders SOX2 H4C1 H4C6 H4-16 SOX11 POU3F2 SOX4 FGF4 SRRT SOX12 YES1 POU3F1 TEAD2 UTF1 SOX15 ZSCAN10 WWTR1 INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20260510%WP453%HOMO SAPIENS Inflammatory response pathway IL2 IL2RB TNFRSF1B CD80 CD28 ZAP70 IL4R CD40LG IFNG LAMC2 LCK IL5 TNFRSF1A IL5RA COL1A2 LAMA5 CD40 THBS3 IL2RG FN1 LAMB2 COL1A1 COL3A1 LAMC1 LAMB1 IL4 IL2RA CD86 THBS1 VTN PROXIMAL TUBULE TRANSPORT%WIKIPATHWAYS_20260510%WP4917%HOMO SAPIENS Proximal tubule transport CA2 CA4 SLC34A1 SLC4A4 SLC12A4 SLC9A3 SLC22A2 ATP1A1 ATP6V1F ABCB1 FXYD2;FXYD6-FXYD2 ABCC4 ABCC2 ATP6V1C1 ATP1B1 SLC2A1 SLC3A2 SLC7A8 ATP6V1E1 ATP6V0E2;ATP6V0E1 SLC16A10 SLC5A1-1 SLC2A2 SLC4A2 SLC22A11 SLC6A19 ATP6V0B SLC13A3 SLC6A18 ATP6V0C ATP6V1B1 ATP6V1A SLC22A6 SLC47A1 ATP6V1G1 SLC20A2 ATP6V1H SLC5A8 ATP6V0A4 ATP6V1D SLC22A8 SLC6A20 SLC22A7 SLC5A2 SLC26A6 SLC5A5 ABCG2 AQP1 SLC7A7 SLC1A1 SLC36A2 CLTRN SLC7A9 SLC3A1 ATP6V0D2 MITOCHONDRIAL FATTY ACID SYNTHESIS PATHWAY%WIKIPATHWAYS_20260510%WP4317%HOMO SAPIENS Mitochondrial fatty acid synthesis pathway HSD17B12 OXSM MCAT ACACA MECR OREXIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260510%WP5094%HOMO SAPIENS Orexin receptor pathway POMC HCRTR2 HCRTR1 STAR GHRL PRKAA1 EIF4B GNAI1 FOXO1-1 CXCL2;CXCL3;CXCL1-1 MAPK1 NFE2L2 ADIPOQ GNA11 BMP7 LEP GRIA1 NOX4 BMPR1A PDK1 IL9 RPS6 RPS6KB1 TNF PDHB RPS6KA1 PRKCB PRKCE PRKCD PRKCA STAT3 MTOR SLC2A1 GNAS-1 RRAGC IL6 DAGLA PRKD1 SLC2A4 CCK IL1B CXCL8 GCG CASP9 PDPK1 PRKCZ CASP3 CGA CAMKK2 DYNLT1 PIK3R2 PIK3R1 EIF4EBP1 CREB1 GNAQ LHB HIF1A NPFFR1 SGK1-1 FSHB PTPN11 NPVF VHL GNRH1 HCRT PLCD1 MAPK9 NPY OPRK1 TH MAPK8 MAP2K2;MAP2K1 IL4 ARRB1 RUNX2 MAPK7 MAPK3 SMAD1 ARRB2 IL10 SLC1A2 PLD1 SMAD5 MAPK14 G13 SIGNALING%WIKIPATHWAYS_20260510%WP524%HOMO SAPIENS G13 signaling PIK3CD PIK3CB IQGAP2 PPP1CB ARHGEF1 WASL RAC1 ROCK1 CFL2 ROCK2 CFL1 WAS PIP4K2A GNA13 PIK3CA CDC42 MYL1 ARHGDIG PFN1 PIK3R2 ARHGDIB RHOA LIMK1 IQGAP1 PAK3 MAP3K4 MAPK10 CALM1 RTKN RHPN2 MYBPH RPS6KB1 PKN1 CIT DIAPH1 TNK2 CYFIP1 SH3RF1 AMYOTROPHIC LATERAL SCLEROSIS ALS %WIKIPATHWAYS_20260510%WP2447%HOMO SAPIENS Amyotrophic lateral sclerosis ALS GPX1 NOS1 BCL2 CASP9 DAXX RAC1 CASP3 CAT NEFL PPP3CB MAP3K5 NEFM PPP3CA PPP3CC APAF1 MAP2K6 NEFH GRIA1 BID TP53 SMIM40 BCL2L1 TNFRSF1A CCS RAB5A BAD BAX MAP2K2;MAP2K1 CASP1 TOMM40 DERL1 TNF PRPH SOD1 ALS2 CST3 SLC1A2 MAPK14 MAPK PATHWAY IN CONGENITAL THYROID CANCER%WIKIPATHWAYS_20260510%WP4928%HOMO SAPIENS MAPK pathway in congenital thyroid cancer KRAS SOS1 SOS2 ALK SHC1-1 MYC ELK1 MAP2K2;MAP2K1 JUN KSR1 MAPK3 BRAF GAREM2 RAF1 FOS EGF EGFR SIGNALING%WIKIPATHWAYS_20260510%WP437%HOMO SAPIENS EGF EGFR signaling RIN1 SP1 RASA1 FOXO4 GRB10 FOSB RICTOR VAV2 JUN MAP3K1 MAPK1 RAF1 AP2S1 RPS6KA5 AP2M1 USP8 ATF1 GJA1 MAP2K5 RPS6KA3 MEF2A PRKCB GAB2 PRKCD CAV2 PRKCA INPP5D PCNA SH3GL3 EPS15 PXDN VAV3 DOK2 PRKCZ ELK4 STMN1 CFL1 STAM NEDD4 PIAS3 ATXN2 RALGDS SYNJ1 DNM1 IQGAP1 HGS ARF6 ITCH EPN1 USP6NL CBLC NDUFA13 INPPL1 TNK2 PEBP1 EPS8 STAMBP STAM2 IQSEC1 PTPRR SH3KBP1 EPS15L1 ASAP1 PTEN REPS2 PTPN12 MAP4K1 VAV1 RALBP1-1 MEF2C CAMK2A ARHGEF1 PTK2B JAK2 SPRY2 HRAS NCOA3 ROCK1 ERRFI1 RALA-1 PIK3C2B AP2A1 FOXO1-1 CDC42 ERBB2 AP2B1 CAV1 CSK PLD2 MAPK4 MEF2D SOS1 LIMK2 SOS2 BCAR1 STXBP1 MAP3K4 RALB SRC RAP1A JAK1 STAT5A STAT5B EGFR STAT1 RPS6KB1 RPS6KA1 ABI1 STAT3 MTOR KRAS GRB2 SHC1-1 CBLB CRKL NCK2 NCK1 ELK1 MAP3K2 PDPK1 MAP3K3 GAB1 RAC1 PLSCR1 AKT1 CRK PTK6 PTPN5 PRKCI FOS CBL PIK3R2 PIK3R1 EIF4EBP1 CREB1 PLCE1 PAK1 E2F1 RAB5A EGF PTPN11 RPS6KA2 MAPK9 MAPK8 MAP2K2;MAP2K1 ABL1 PLCG1 MAPK7 JUND PLD1 NOS3 BRAF MAPK14 SH3GL2 PTK2 INTERFERON SIGNALING IN TUBERCULOSIS%WIKIPATHWAYS_20260510%WP4197%HOMO SAPIENS Interferon signaling in tuberculosis IFNAR1 IFNGR2 IFNG IRF9 IFI35 PSMB8 STAT2 IFIT3 MX1-1 JAK1 TAP1 STAT1 JAK2 SOCS1 PIAS1 IRF1 IFNAR2 PTPN2 IFNGR1 OAS1 TYK2 IFIT1 IFITM3;IFITM2;IFITM1 CODEINE AND MORPHINE METABOLISM%WIKIPATHWAYS_20260510%WP1604%HOMO SAPIENS Codeine and morphine metabolism UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ABCC2 UGT1A1;UGT1A6 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ABCB1 CYP2D6;LOC107987479;LOC107987478-1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC3 DISRUPTION OF POSTSYNAPTIC SIGNALING BY CNV%WIKIPATHWAYS_20260510%WP4875%HOMO SAPIENS Disruption of postsynaptic signaling by CNV GRIN2C NLGN3 CAMK2B NLGN2 CAMK2D NLGN4X;NLGN4Y CAMK2A DLG2 NRXN3 NRXN2 MAPK1 NRXN1;NRXN3;NRXN2 SHANK1 DLG1 GRIN2A CAMK2G NLGN1 ARC GRM1 GRIN2D RPH3A FMR1 SYNGAP1 DLGAP1 RYR2 STX1A HOMER1 GRIN2B GRIN1 MAPK3 CYFIP1 TJP1 YWHAG DENGUE 2 INTERACTIONS WITH COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260510%WP3896%HOMO SAPIENS Dengue 2 interactions with complement and coagulation cascades BDKRB1 F12 F13B KLKB1 F2 SERPINE1 PLAUR PROS1 CLU C3AR1 LOC110384692;C4A;C4B_2;C4B SERPING1 MASP2 MASP1 PLAU CFB CFD CFI C5AR1 APOA2 C2 C6 PROC FGB F9 C7 C9 F10 SERPINA5 THBD F7 VWF PLG SERPINF2 F5 CFH-3 CLTC F8 CPB2 SERPINC1 TFPI LMAN1 C8G SERPIND1 PLAT CR2 F2R C1QB C1S C1R CD55 CR1L;CR1 SERPINA1 C3-1 C1QC KNG1 F3 KININ KALLIKREIN PATHWAY%WIKIPATHWAYS_20260510%WP5089%HOMO SAPIENS Kinin Kallikrein pathway SERPING1 BDKRB2 BDKRB1 F12 KLKB1 KNG1 CPN1 INVOLVEMENT OF SECRETASE IN NEURODEGENERATIVE DISEASES%WIKIPATHWAYS_20260510%WP5372%HOMO SAPIENS Involvement of secretase in neurodegenerative diseases BACE1 CEBPB BDNF TARDBP LGMN AKT2 AKT3 MAOB STAT1 PPP2CB;PPP2CA APP NTRK2 AKT1 MAPT SNCA SET-1 SRPK2 POST COVID NEUROINFLAMMATION%WIKIPATHWAYS_20260510%WP5485%HOMO SAPIENS Post COVID neuroinflammation IL2 GFAP ACE2 IFNG IL6 IL1A TLR4 HMGB1-1 IL1B TLR7 TLR3 CXCL8 IL4 TLR8 TNF IL10 MAPK1 CCL11 IL18 TMPRSS2 FURIN IL12A GENES AND COMPLEXES INVOLVED IN THE DNA REPAIR PATHWAYS%WIKIPATHWAYS_20260510%WP4946%HOMO SAPIENS Genes and complexes involved in the DNA repair pathways CHEK1 RBX1 BRCA1 PARP2 PRKDC CDK7 ATR PCNA FEN1 POLB FANCD2 POLE RFC5 RFC3 BRIP1 RFC4 APEX1 USP1 MRE11 MSH6 BRCA2 RAD54B XRCC5 POLD4 PALB2 RAD50 RAD51 POLD1 POLD3 POLD2 NBN HMGB1-1 MGMT RPA1 RPA2 FAN1 FANCG MSH3 RPA3 LIG4 POLE2 GTF2H2C;GTF2H2C_2;GTF2H2 CETN2 XPA XPC RFC1 LIG1 RFC2 RAD23A GTF2H1 MSH2 ERCC5;BIVM-ERCC5 GTF2H3 GTF2H4 RAD23B TDG CUL4A DDB1 ERCC3 ERCC4 ERCC1 ERCC2 ERCC8 FAAP100 MNAT1 REV1 CUL4B CENPS-CORT;CORT;CENPS FANCE FANCF REV3L FANCI POLI POLH POLE4 RAD51C FAAP24 XRCC4 LOC105377022;FANCB FANCM PMS2 FANCL CENPX POLM APEX2 POLE3 FANCA FANCC MPG OGG1 PNKP UNG NTHL1 POLL RAP1A MUTYH MBD4 XRCC1 SMUG1 NEIL3 NEIL2 EXO1 TERF2 LIG3 XRCC6 WDR48 WRN POLK MLH1 DDB2 PARP1 ERCC6 DCLRE1C NHEJ1 RAD52 ATM CCNH GASTRIC CANCER NETWORK 2%WIKIPATHWAYS_20260510%WP2363%HOMO SAPIENS Gastric cancer network 2 CTNNB1 MYC TOP2A FANCI PLAC8 RFC3 LBR RFC4 AHCTF1 DSCC1 CHTF18 MTDH BRIX1 UBE2C ATAD2 CACYBP FAM91A1 RNF144B TP53 UBE2T RAD17 COL9A1 SNURF CD48 COL9A3 CEBPZ LMNB2 EGFR S100A6 OTUD5 ESTROGEN RECEPTOR PATHWAY%WIKIPATHWAYS_20260510%WP2881%HOMO SAPIENS Estrogen receptor pathway CYP1A1 CYP1A2 PCK1 NR0B2 ACOX1 PPARA SP1 PDK4 GPAM JUN ESR1 STAT3 CYP1B1 FIBROTIC RESPONSE OF TRABECULAR MESHWORK CELLS TO TGFB3 AND ENPP2 IN AQUEOUS HUMOR%WIKIPATHWAYS_20260510%WP5545%HOMO SAPIENS Fibrotic response of trabecular meshwork cells to TGFB3 and ENPP2 in aqueous humor TGFB2 CCN2 TGFB3 ACTA2 MAPK10 FN1 ENPP2 MAPK9 COL1A1 RHO MAPK8 TGFB1 STAT3 SMAD2;SMAD3 ARTEMISININ INHIBITION OF UVEAL MELANOMA%WIKIPATHWAYS_20260510%WP5441%HOMO SAPIENS Artemisinin inhibition of uveal melanoma AKT1 MTOR AKT2 AKT3 INTERLEUKIN 1 IL 1 STRUCTURAL PATHWAY%WIKIPATHWAYS_20260510%WP2637%HOMO SAPIENS Interleukin 1 IL 1 structural pathway IRAK2 TOLLIP TAB1 MYD88 IRF7 ATF2 MYC ELK1 MAP2K4 NFKBIB MAP3K3 IRAK4 TAB3 IKBKB EIF4E NFKBIA MAP3K1 CHUK IL1RAP MAP3K8 TRAF6 MAPKAPK2 MAPK1 MAP3K14 FOS NFKB1 MAP2K6 RPS6KA5 MAPK11 TANK MAP2K7 IL1R1 IL1A MAP2K3 MBP MAPK10 RELA SAFB MAPK9 MAP3K7 MAPK8 MAP2K2;MAP2K1 IRAK1 MAPK3 TAB2 MAPK14 MKNK1 MKNK2 ENTEROHEPATIC CIRCULATION OF BILE ACIDS%WIKIPATHWAYS_20260510%WP5396%HOMO SAPIENS Enterohepatic circulation of bile acids ABCC4 ABCC2 SLC10A1 SLC10A2 SLC51A SLC51B ABCB1 FABP6 ABCB11 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC3 OVERLAP BETWEEN SIGNAL TRANSDUCTION PATHWAYS CONTRIBUTING TO LMNA LAMINOPATHIES%WIKIPATHWAYS_20260510%WP4879%HOMO SAPIENS Overlap between signal transduction pathways contributing to LMNA laminopathies CEBPA CEBPD TCF7 CTNNB1 DICER1 TARBP2 NOTCH1 TCF7L2 CTSK AXIN1 CDK4 CREBBP KAT2B TNFRSF11B TCF7L1 PPARG SMAD2;SMAD3 TGFB2 LEF1 HES5 TMPO LEMD3 ZMPSTE24 CSNK1A1 APC HDAC1 FNTA NAP1L1 EMD ICMT TLE1 HMGA2 AGO2 GSK3B LMNA SREBF1 JUNB HES1 MYOD1 E2F1 WNT10B CEBPB SPP1 WNT7B MSTN MAOB MAOA RB1 RUNX2 TGFB1 ACTB-1 BMP2 CDKN1A METASTATIC BRAIN TUMOR%WIKIPATHWAYS_20260510%WP2249%HOMO SAPIENS Metastatic brain tumor CDK6 PIK3R1 TP53 E2F3 CDC42 MYC BMP SIGNALING IN EYELID DEVELOPMENT%WIKIPATHWAYS_20260510%WP3927%HOMO SAPIENS BMP signaling in eyelid development FGF10 SMAD4 FGFR2 NOTCH1 EGFR MAPK9 SHH INHBB FOXC1 PITX2 FOXC2 SMAD1 JUN MAP3K1 MAPK3 BMP4 DKK2 SMAD5 SFRP1 TGFA CATABOLISM OF SKELETAL MUSCLE IN CACHEXIA%WIKIPATHWAYS_20260510%WP5474%HOMO SAPIENS Catabolism of skeletal muscle in cachexia REL EP300 IL6 IGF1R RPTOR IGF1 IL1B MAP1LC3A MLST8 IL6R IKBKB AKT1 NFKBIA NFKB2 CHUK IKBKG NFKB1 AKT1S1 SMAD2;SMAD3 MAPK11 SMAD4 IL1R1 IL1A TNFRSF1A CEBPB FOXO3 RELB RELA PDK1 JAK1 MSTN TRIM63 FBXO32 TNFRSF12A ACVR2A TNF STAT3 MTOR FOXA2 PATHWAY%WIKIPATHWAYS_20260510%WP5066%HOMO SAPIENS FOXA2 pathway MTTP ACACA GSTA3;GSTA5;GSTA1;GSTA2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC3 IRS2 APOB ABCC4 IRS1 SREBF1 ABCC2 FASN FOXA2 INS;INS-IGF2 FOXO1-1 FOXA1 PPARGC1B GSTM1;GSTM2-1 SLC27A5 GSTA3;GSTA1 LEUCINE ISOLEUCINE AND VALINE METABOLISM%WIKIPATHWAYS_20260510%WP4686%HOMO SAPIENS Leucine isoleucine and valine metabolism MMUT PCCA BCKDHA PCCB ECHS1 IVD ACADSB ACAT1 ALDH6A1 ACAD8 HIBADH MCCC2 BCKDHB HSD17B10 ACSF3 AUH MCCC1 DBT MLYCD BCAT1 HMGCLL1 HIBCH DLD BCAT2 FGFR4 P G388R SIGNALING%WIKIPATHWAYS_20260510%WP5428%HOMO SAPIENS FGFR4 p G388R signaling FGFR4 IL10 STAT3 WNT SIGNALING IN ADULT HIPPOCAMPAL NEUROGENESIS%WIKIPATHWAYS_20260510%WP5536%HOMO SAPIENS Wnt signaling in adult hippocampal neurogenesis WNT7A PROX1 NEUROG2 LRP6 FZD1 WNT5A WNT3 NEUROD1 FZD3 CCND1 WNT3A LAMIN A PROCESSING PATHWAY%WIKIPATHWAYS_20260510%WP4299%HOMO SAPIENS Lamin A processing pathway LMNA ZMPSTE24 ICMT MULTIPLE EPIPHYSEAL DYSPLASIA AND PSEUDOACHONDROPLASIA GENES%WIKIPATHWAYS_20260510%WP4789%HOMO SAPIENS Multiple epiphyseal dysplasia and pseudoachondroplasia genes COMP MATN1 COL9A2 MATN3 COL9A1 COL9A3 NANOPARTICLE TRIGGERED REGULATED NECROSIS%WIKIPATHWAYS_20260510%WP2513%HOMO SAPIENS Nanoparticle triggered regulated necrosis MAPK8 FTL-1 CASP8 RIPK1 FADD TNF PLA2G4A TICAM1 TNFRSF1A RIPK3 PARP1 TRADD LNCRNA MEDIATED MECHANISMS OF THERAPEUTIC RESISTANCE%WIKIPATHWAYS_20260510%WP3672%HOMO SAPIENS lncRNA mediated mechanisms of therapeutic resistance WNT6 TP53 BCL2L1 HIF1A ABCB1 CDKN1A SEBALEIC ACID FORMATION AND METABOLISM%WIKIPATHWAYS_20260510%WP5315%HOMO SAPIENS Sebaleic acid formation and metabolism FADS2 FADS1 ACSL1 ALOX5 CYP4F3;CYP4F2;CYP4F12;CYP4F11 HEME BIOSYNTHESIS%WIKIPATHWAYS_20260510%WP561%HOMO SAPIENS Heme biosynthesis ALAD ALAS2 ALAS1 FECH UROD UROS PPOX CPOX HMBS ALTERED GLYCOSYLATION OF MUC1 IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260510%WP4480%HOMO SAPIENS Altered glycosylation of MUC1 in tumor microenvironment MUC1 IL6 IKBKB NFKBIA TNF CHUK IKBKG RELA NFKB1 BDNF SIGNALING IN NEURODEVELOPMENT%WIKIPATHWAYS_20260510%WP5541%HOMO SAPIENS BDNF signaling in neurodevelopment TIAM2 ARHGDIA BCL2 CTNNB1 TRADD TCF7L2 WASL IKBKB NFKBIA EIF4E JUN MAP3K1 CHUK PIK3CA TRAF6 MAPK1 IKBKG RAF1 TCF7L1 MAP2K5 BDNF PRKCG PRKCH PRKCB PRKCE PRKCD PRKCA SH2B2 MKNK1 ARHGAP35 PRKCZ CFL2 STMN1 CFL1 MAPKAPK2 YWHAE SORT1 YWHAB DIAPH1 DOCK7 YWHAQ YWHAG YWHAH YWHAZ PIK3CD PIK3CB PIK3CG TCF7 IQGAP3 MYC RAPGEF1 IRS2 IRS1 HRAS ROCK1 ROCK2 CDC42 APAF1 BMP7 LIMK1 MAPK11 CASP8 SOS1 BCL2L11 FADD TP53 EEF2K FOXO3 LEF1 PARD3 TIAM1 RPS6KB1 NGFR RPS6KB2 NTRK2 STAT3 MTOR KRAS GRB2 SHC1-1 NPTX2 RND3 GSK3B SMPD1 MAP2K4 CASP9 PDPK1 MAP3K3 GAB1 RAC1 AKT1 MAP3K5 CRK PRKCI RHOA EIF4EBP1 CREB1 MAP2K7 NRAS PAK1 CYCS-1 PARD6B PARD6A BAD PTPN11 EEF2 RAP1B BAX FRS2 MAPK8 MAP2K2;MAP2K1 PLCG1 MAPK7 MAPK3 RTN4R LINGO1 TP73 KIDINS220 PROSTAGLANDIN SIGNALING%WIKIPATHWAYS_20260510%WP5088%HOMO SAPIENS Prostaglandin signaling MMP9 CXCL10 IL6 PYCARD PIK3CG CCL3L1;CCL3L3;CCL3;CCL18 IRF7 IL1B AREG CD28 CXCL9 KLRD1 CXCL8 VEGFA CSF1 AHR CCR2 CXCL2;CXCL3;CXCL1-1 NFKB1 IL12A IFNG IL1A PTGER4 PTGER2 CCL13;CCL2 CASP1 TNF IL17F NLRP3 TGFB1 IL17A PTGES DOWNREGULATION OF ACE2 BY SARS COV 2 SPIKE PROTEIN%WIKIPATHWAYS_20260510%WP4799%HOMO SAPIENS Downregulation of ACE2 by SARS CoV 2 spike protein ACE2 AGTR1 AGTR2 ACE WNT SIGNALING AND PLURIPOTENCY%WIKIPATHWAYS_20260510%WP399%HOMO SAPIENS Wnt signaling and pluripotency SOX2 EP300 FOSL1 ESRRB CTBP1 NLK CTNNB1 DVL1 DVL2 DVL3 TCF7L2 POU5F1;POU5F1B AXIN1 CREBBP TPTEP2-CSNK1E;CSNK1E JUN CD44 TCF7L1 FOXD3 NANOG;NANOGP8 CTNND1 RACGAP1 PRKCG PRKCH PRKCB PRKCE PRKCD PRKCA PTPA PRKCQ PRKD1 PRKCZ LRRK2 CTBP2 PPP2CB;PPP2CA WNT4 PPP2R1B PPP2R1A LDLR PPP2R3B CCND1 TCF7 PPP2R3A MYC PPP2R2C ZBTB33 PPP2R2B PPP2R2A;PPP2R2D NFYA-1 MMP7 AXIN2 TP53 PAFAH1B1 PPARD LEF1 LRP5 MAP3K7 LRP6 WNT1 PLAU FZD6 APC NKD1 NKD2 GSK3B FBXW2 PPM1J MAP2K4 WNT2B FZD10 WNT5B WNT9B WNT16 PRKCI RHOA WNT6 WNT11 WNT2 WNT3 WNT10B WNT10A FZD3 FZD2 MAPK10 FZD5 FZD4 WNT3A WNT7B FZD7 FZD9 MAPK9 WNT7A FZD8 FZD1 CCND3 WNT5A PPP2R5E CCND2 PPP2R5C 15Q13 3 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP4942%HOMO SAPIENS 15q13 3 copy number variation syndrome MTMR10 OTUD7A FYN KLF13 GRM6 GPR75 FAN1 CREBBP CHRNA7;CHRFAM7A FANCD2 CCL5 TRPM1 KAT2B SERPINH1 RETINOL METABOLISM%WIKIPATHWAYS_20260510%WP5188%HOMO SAPIENS Retinol metabolism CYP2W1 CYP1A1 AOX1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 DHRS9 RPE65 RDH12 DHRS4 SDR16C5 LRAT AWAT2 PNPLA4 RDH13 BCO1 ADH1C;ADH1B;ADH1A CYP2A13;CYP2A6;CYP2A7-1 ALDH1A1 CIRCADIAN RHYTHM GENES%WIKIPATHWAYS_20260510%WP3594%HOMO SAPIENS Circadian rhythm genes UTS2R EP300 BTBD9 SKP1 HCRTR2 HCRTR1 ADORA2A MTNR1B GHRH DYRK1A GHRL NR1D2 ADA PHLPP1 PRKDC CUL1 CDK4 SFPQ-1 CSNK1D EZH2 TPTEP2-CSNK1E;CSNK1E BTRC NOS2 CHRM1 PRKCG RAI1 SIK1;SIK1B HDAC2 HDAC1 TOP2A SUV39H1 SREBF1 CCAR2 EGR3 SIN3A CRY2 GNAQ MTA1 TYMS ZFHX3 ARNT DDC TH DBP KLF9 UBB;UBC PER2 SERPINE1 UBE3A ID4 SLC9A3 EGR1 ADCY1 BHLHE40 NCOR1 PPARG GNA11 ID2-1 HNRNPU ID3 CPT1A NR1H3 HS3ST2 METTL3 IL6 UBA52 PPARA GSK3B DHX9 KCND2 NCOA2 LGR4 SFTPC CREB1 CRTC1 NONO CRH AVP PRKAA2 MAPK10 RELB HTR7 MAPK9 HNRNPD MAPK8 FAS SLC6A4 HDAC3 JUND MYBBP1A NTRK3 SIX3 STAR PPP1CB PRKAA1 TPH1 NR2F6 DDX5 JUN NKX2-1 MAGED1 PPARGC1A SUV39H2 AANAT KMT2A ATF4 CREM RPS27A TOP1 NRIP1 MTTP GFPT1 PRF1 PTEN FBXW11 ARNT2 ROCK2 HNF1B TNFRSF11A ADIPOQ LEP TPH2 NLGN1 TP53 MTNR1A SETX HOMER1 THRAP3 NTRK1 NGFR PPP1CC PML PROX1 F7 CRX PRMT5 SIRT1 NAMPT PPP1CA RORC RORA DRD4 PROK1 AHR SOX14 CLDN4 ATF5 NMS FBXL3 BHLHE41 PAX4 MC3R KCNMA1 CIPC ARNTL2 PROKR1 CAVIN3 RORB CRY1 CLOCK NAGLU KCNH7 USP2 ARNTL CARTPT PROKR2 PSPC1 TIMELESS PROK2 NFIL3 MAGEL2 OPN4 OPN3 OGT-1 RBM4;RBM4B AGRP KDM5A NR1D1 HEBP1 KLF10 AHCY PER1 OPRL1 NPY2R CIART NPAS2 PRKG2 ATOH7 NPS NOCT CST3 ADORA1 DRD1 PTGDS DRD2 DRD3 CHRNB2 EFFECTS OF MFN2 MUTATION%WIKIPATHWAYS_20260510%WP5443%HOMO SAPIENS Effects of MFN2 mutation DYNC1I1 CASP8 TUBB3;TUBB6 DYNC2H1 DYNC1LI2 TP53 RAB7A SYPL1 BAX DYNC1H1 MAP2 CASP3 SNCA RAB3B TRAK1 ATAT1 DYNC2I2 RHOT1 DYNC2I1 DCTN1 KIF1B MFN2 RABAC1 RAB3A FAMILIAL HYPERLIPIDEMIA TYPE 1%WIKIPATHWAYS_20260510%WP5108%HOMO SAPIENS Familial hyperlipidemia type 1 LRP1 APOA5 LPL LCAT APOA4 ANGPTL8 ANGPTL3 LIPC LDLR SEL1L LMF1 PLTP GPIHBP1 APOC2 APOA2 APOA1 ANGPTL4 CETP TGF BETA SIGNALING IN THYROID CELLS FOR EPITHELIAL MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260510%WP3859%HOMO SAPIENS TGF beta signaling in thyroid cells for epithelial mesenchymal transition SMAD4 TNC CDH2 ID1 FN1 AKT2 VIM AKT3 CDH1 AKT1 RUNX2 MAPK3 SNAI1 MAPK1 CDH16 SNAI2 CDH6 SMAD2;SMAD3 AMP ACTIVATED PROTEIN KINASE SIGNALING%WIKIPATHWAYS_20260510%WP1403%HOMO SAPIENS AMP activated protein kinase signaling SLC2A4RG PIK3CD STK11 PIK3CB HNF4A PIK3CG RPTOR AKT2 PRKAA1 PIK3C3 PLCB1 FASN ELAVL1 TSC2 INS;INS-IGF2 TSC1 PIK3CA ADIPOR2 ACACB CCNB1 PRKACB-1 PPARGC1B ADIPOQ LEPR LEP PRKAB2 PRKAB1 TP53 EEF2K CCNA2-1 PRKAG1 PRKAG2 RPS6KB1 PRKAG3 RPS6KB2 CCNA1 INSR CPT1A STRADB MTOR CRTC2 HMGCR GYS2 SLC2A4 PFKFB3 SREBF1 CAB39 AKT1 GYS1 CAMKK1 CAMKK2 PIK3R3 PIK3R2 PIK3R1 EIF4EBP1 PRKAA2 ACACA LIPE EEF2 CPT1C CPT1B ADRA1B ADRA1A STRADA CDKN1A ADIPOR1 FOCAL ADHESION PI3K AKT MTOR SIGNALING%WIKIPATHWAYS_20260510%WP3932%HOMO SAPIENS Focal adhesion PI3K Akt mTOR signaling VEGFC TCL1B ITGAV TCL1A CAB39L HIF3A PHLPP2 IL2RB COL11A1 COL11A2 PFKFB1 PFKFB4 TBC1D1 EIF4E2 PPP2R3C PHLPP1 PIK3IP1 EIF4B ANGPT4 IKBKB COL4A2 MAPK1 IKBKG FOXA1 RAF1 NOS2 CHRM2 CHRM1 EFNA5 EFNA4 ITGA5 ULK1 EFNA1 EFNA3 EFNA2 THBS1 CRTC2 NOS1 PFKFB2 RAB8A PFKFB3 SREBF1 CAB39 PRL GYS1 GNG13 GNB2 GNB1 CDC37 GNB4 GNB3 ITGA10 RAB10 PPP2CB;PPP2CA HSP90B1 GNGT1 ITGA2 PPP2R1B ITGB7 PPP2R1A PPP2R5B PPP2R5A PPP2R5D RELN ATF2 PPP2R3A PPP2R2C PPP2R2B PPP2R2A;PPP2R2D IRS1 PIK3R4 PIK3C2A PIK3C2B PIK3R5 ELAVL1 INS;INS-IGF2 GNG2 GNG5 GNG4 GNG8 TNC FOXO3 JAK1 PRLR RPS6 LAMC1 RPS6KB1 RPS6KB2 OSM VTN ITGA3 ITGAM ITGB2 ITGA6 GSK3B ITGAX CASP9 PDPK1 AKT1 HSP90AA1 IBSP COMP EIF4EBP1 TNN CREB1 TNR NGF RAB11B CHAD COL2A1 COL5A3 COL5A2 EGF COL6A2 PRKAA2 EPAS1 ITGB1 ACACA LAMA5 THBS4 SPP1 THBS3 PDGFA TNXB FGF1 COL1A1 COL3A1 MAP2K2;MAP2K1 MAPK3 NOS3 PPP2R5E PPP2R5C PTK2 IL2 STK11 DDIT4 PRKAA1 EIF4E VEGFA IFNAR2 PIK3CA ITGB4 IFNAR1 EPO EPOR KITLG IFNB1-4 PPARGC1A IL3RA ATF6B CREB3L3 CREB3L4 CREB3L1 CREB3L2 IL2RG JAK3 CREB3 ATF4 CREB5 GYS2 FGF2 FGF3 FGF4 FGF6 GHR FGF7 FGF8 OSMR FGF9 CSF1 F2R PDGFB FGF20 FGF22 FGF21 FN1 GNG10 CSF3R ITGA2B FGF17 IRS4 PGF FGF16 FGF14 THBS2 COL5A1 FGF19 FGF18 FGF13 HSP90AB1 FGF12 CDKN1A FGF11 FGF10 FLT1 HGF FLT4 EIF4E1B PTEN PIK3CD PIK3CB PIK3CG LPAR2 IGF1R LPAR3 RPTOR LPAR4 LPAR5 LPAR6 AKT2 AKT3 IRS2 MLST8 KDR JAK2 VEGFD IL6R HRAS PDGFRB PDGFRA TSC2 COL4A1 TSC1 COL4A4 FOXO1-1 COL4A6 AKT1S1 KIT IL7R LAMC3 SOS1 LAMC2 MET EPHA2 COL1A2 CSF1R LAMA2 MDM2-2 LAMA1 LAMA4 LAMA3 LPAR1 EGFR LAMB3 LAMB2 LAMB1 NGFR INSR ITGA11 ITGB5 ITGAE ITGB8 ITGAD MTOR ITGA8 RAB2A SLC2A1 ITGA7 ITGA9 RHEB KRAS GRB2 TEK FGFR4 ITGAL FGFR3 VWF FGFR2 SLC2A4 FGFR1 IGF1 SLC2A2 CSF3 ITGB6 IL4R PIK3R2 PIK3R1 NRAS HIF1A BAD RAB14 LIPE PDGFD PDGFC VEGFB CDKN1B IL2RA ANGPT2 ITGA4 ITGB3 ANGPT1 STRADA PHOSPHOINOSITIDES METABOLISM%WIKIPATHWAYS_20260510%WP4971%HOMO SAPIENS Phosphoinositides metabolism PTEN PLCB3 PIK3CD PIK3CB PIK3CG MTMR12 MTMR11 SBF1 PIK3C3 PLCB1 SBF2 PIK3R4 PIK3C2G MTMR3 PIK3C2A MTMR9 MTMR4 MTMR7 PIK3C2B PIK3CA PLCZ1 PLCD4 PLCH1 PLCB2 OCRL INPP5D PLCH2 PIP4K2A PIP4K2B PIP4K2C MTMR1 MTMR2 MTMR8 MTMR6 MTM1 PIP4P2 PIP4P1 PLCE1 MTMR10 SACM1L PIP5K1A PIP5K1B PIP5K1C PIKFYVE PLCB4 PLCD3 PLCD1 PLCG2 PLCG1 GLYCOLYSIS IN SENESCENCE%WIKIPATHWAYS_20260510%WP5049%HOMO SAPIENS Glycolysis in senescence HK1 LDHA GAPDH-1 PKM PGK1 ALDOC TP53 RB1 G6PD PRKAA1 ENO1 MAMMARY GLAND DEVELOPMENT PREGNANCY AND LACTATION STAGE 3 OF 4%WIKIPATHWAYS_20260510%WP2817%HOMO SAPIENS Mammary gland development pregnancy and lactation stage 3 of 4 PTPN1 ORAI1 CEBPA PGR CCND1 USF1 MYC JAK2 NRG1 EIF4E PNCK NFIA PRL ATP2C2 ESR1 DLGAP4 CHUK ERBB2 TFPI2 CAV1 CLDN6 TNFRSF11A TTC9 GAL NFIC HDGFL2 ERBB3 TNFSF11 GJB2 ERBB4 BCL2L1 CEBPB CSN2-1 STAT5A EGFR STAT5B NR3C1 PRLR NFIX TPM3 NFIB ELF5 USF2 EIF4G1 YY1 ESR2 TNF RELATED WEAK INDUCER OF APOPTOSIS TWEAK SIGNALING%WIKIPATHWAYS_20260510%WP2036%HOMO SAPIENS TNF related weak inducer of apoptosis TWEAK signaling TRAF1 HDAC1 TRAF3 CTNNB1 BIRC2 GSK3B AKT2 NFKBIB RAC1 IKBKB CASP3 AKT1 NFKBIA JUN NFKB2 CHUK BIRC3 MAPK1 TRAF2 RAF1 TRAF5 MAP3K14 NFKB1 CASP7 CASP8 RIPK1 FADD RELB RELA MAPK9 MAP3K7 TRIM63 MAPK8 TNFRSF12A TNF MAPK3 MAPK14 METABOLISM OF ALPHA LINOLENIC ACID%WIKIPATHWAYS_20260510%WP4586%HOMO SAPIENS Metabolism of alpha linolenic acid FADS2 ALOX15 FADS1 ALOX12 PTGS2-2 ALOX5 GABA METABOLISM AKA GHB %WIKIPATHWAYS_20260510%WP4157%HOMO SAPIENS GABA metabolism aka GHB ADHFE1 DPEP1 GAD1 GAD2 AKR7A2 GLS ALDH5A1 GLS2 ABAT PON3 MAOB TRYPTOPHAN CATABOLISM LEADING TO NAD PRODUCTION%WIKIPATHWAYS_20260510%WP4210%HOMO SAPIENS Tryptophan catabolism leading to NAD production NMNAT3 NMRK1 NAPRT HAAO TDO2 AFMID AADAT IDO1 NMNAT1 QPRT NMNAT2 KYNU KMO NAMPT NADSYN1 NMRK2 FOLLICLE STIMULATING HORMONE FSH SIGNALING%WIKIPATHWAYS_20260510%WP2035%HOMO SAPIENS Follicle stimulating hormone FSH signaling EIF4EBP1 CREB1 FSHR H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SRC SGK1-1 FSHB APPL1 RPS6 RPS6KB1 RPS6KB2 AKT1 MAPK3 TSC2 CGA FOXO1-1 GRK6 PRKCA MAPK1 MTOR PRKACA-1 RAF1 MAPK14 RHEB HYPOTHETICAL CRANIOFACIAL DEVELOPMENT PATHWAY%WIKIPATHWAYS_20260510%WP3655%HOMO SAPIENS Hypothetical craniofacial development pathway ARHGEF2 TP63 TGFB3 ARHGAP29 TFAP2A IRF6 RHOA HEART DEVELOPMENT%WIKIPATHWAYS_20260510%WP1591%HOMO SAPIENS Heart development VEGFC FGF10 NFATC3 HAND2 NFATC4 GATA6 GATA4 NFATC2 NKX2-5 CTNNB1 MEF2C NOTCH1 SRF FOXC1 FGF8 VEGFA BHLHE40 MAPK1 FOXH1 ERBB3 SMAD4 TBX1 TBX20 IRX4 TBX5 ISL1 TBX2 HAND1 BMPR1A PTPN11 BMPR2 HEY2 SHH VEGFB NFATC1 PITX2 FOXC2 FOXA2 SMAD1 BMP4 BMP10 BMP2 SMYD1 HEY1 HDAC6 INTERACTIONS IN THE CENTRAL NERVOUS SYSTEM%WIKIPATHWAYS_20260510%WP5426%HOMO SAPIENS HDAC6 interactions in the central nervous system EP300 SP1 BCL2 GRK2 CTNNB1 POU5F1;POU5F1B ACTR1A DLG2 BIRC5 MYH9 MAPK1 SMAD2;SMAD3 VCP-1 APOE HDAC11 BDNF KALRN ATXN3 VIM UBD G3BP1 CCDC141 HSPA4 CNOT6 OPTN-1 ITIH4 NEDD9 HSF1 SNCA SGK3;C8orf44-SGK3 PRKCE MIIP ELP1 HTT ELP3 ARID3A GARS1 EP400 HSPA8 AURKA ISG15 MYD88 CYBB PRKCZ HDAC9 MAPRE1-1 TPPP NDUFV1 SNCAIP MAP1B PXN PRKN SGK1-1 SOD1 DNAJA1-1 ERG RAD23B TARDBP PARK7 KAT5 PTK2B BBIP1 MDH1 PRDX1 GRIA1 STUB1 GRIA2 GSK3A DYNC1I2 HDAC6 EGFR PROM1 DLG4 MAPT CSNK2A2 CSNK2B APC XRCC6 HSPB1 GSK3B SQSTM1 MAP1LC3A SIRT2 TUBA1C PPP1CA RAC1 AKT1 TUBA3E;TUBA3C-1 MAP3K5 TUBA4A HSP90AA1 CTTN DCTN1 CFTR ATP13A2 FOXP3 TUBB4A;TUBB;TUBB8B;TUBB8 SMAD7 FUS TUBB3;TUBB6 HIF1A VHL SHH BAX NR3C1 MAPK8 PRDX2 MIF MAPK3 RHOT1 CDC20 PANCREATIC ADENOCARCINOMA PATHWAY%WIKIPATHWAYS_20260510%WP4263%HOMO SAPIENS Pancreatic adenocarcinoma pathway PIK3CD RAC3 PIK3CB TGFBR2 CCND1 CDKN2A RALBP1-1 AKT2 AKT3 CDK6 CDK4 ARHGEF6 IKBKB RALA-1 VEGFA CHUK PIK3CA CDC42 ERBB2 MAPK1 IKBKG RAF1 PLD2 NFKB1 SMAD2;SMAD3 TGFB2 SMAD4 TGFB3 TP53 BCL2L1 RALB JAK1 EGFR STAT1 RPS6KB1 RPS6KB2 PRKCD STAT3 MTOR RIPK4 DUSP6 KRAS BUB1B-PAK6;PAK6 ARAF CASP9 TGFBR1-1 RAC1 POLK AKT1 RALGDS DDB2 TGFA PIK3R3 PIK3R2 BRCA2 PIK3R1 PAK1 PAK3 PAK2 RAD51 E2F1 PAK5 E2F2 PAK4 E2F3 EGF BAK1 MAPK10 GADD45B BAD RELA GADD45A GADD45G MAPK9 BAX MAPK8 MAP2K2;MAP2K1 RB1 MAPK3 TGFB1 PEBP1 PLD1 BRAF CDKN1A THYROXINE THYROID HORMONE PRODUCTION%WIKIPATHWAYS_20260510%WP1981%HOMO SAPIENS Thyroxine thyroid hormone production CLCN5 DUOX2 TG PRKAA1 ELK1 CGA MAPK1 TSHR RAF1 NFKB1 CREB1 SLC26A6 PRKAA2 SLC5A5 RAP1A RAP1B PLCD1 MAP2K2;MAP2K1 TPO MAPK3 PRKCA TRH DUOX1 ACY1;ABHD14A-ACY1 ANO1 INTERACTIONS BETWEEN LOXL4 AND OXIDATIVE STRESS PATHWAY%WIKIPATHWAYS_20260510%WP3670%HOMO SAPIENS Interactions between LOXL4 and oxidative stress pathway DDR1 NQO1 EXOC6 COL2A1 IGFBP7 CDC37 NRF1 FN1 SIRT1 SUV39H1 FGF7 ECSIT ANXA5 LOXL4 PKD1 TGFB1 NFE2L2 BMP2 TRANSLATION INHIBITORS IN CHRONICALLY ACTIVATED PDGFRA CELLS%WIKIPATHWAYS_20260510%WP4566%HOMO SAPIENS Translation inhibitors in chronically activated PDGFRA cells EIF4G3 PIK3CB PIK3CG RPTOR PIM1 PIM2 EIF4A1 AKT2 AKT3 MAP2K4 PDCD4 EIF4B AKT1 EIF4E PIK3CA MAPK1 PIK3R3 PIK3R2 MAP2K6 PIK3R1 RPS6KA5 EIF4EBP1 MAP2K7 MAP2K3 MAPK10 MAP2K5 PDK1 RPS6KA2 MAPK9 MAPK8 MAP2K2;MAP2K1 RPS6 RPS6KB1 RPS6KB2 CSNK2A1;CSNK2A3 RPS6KA1 MAPK3 RPS6KA4 PRKCD PRKCA EIF4A2 MTOR PRKACA-1 MAPK14 EIF4G1 ESTRADIOL REGULATION IN PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260510%WP5235%HOMO SAPIENS Estradiol regulation in porto sinusoidal vascular disease SP3 KCNN3 ESR1 SP1 CALM1 BUTYRATE INDUCED HISTONE ACETYLATION%WIKIPATHWAYS_20260510%WP2366%HOMO SAPIENS Butyrate induced histone acetylation AKT1 ACLY PHOTODYNAMIC THERAPY INDUCED NF KB SURVIVAL SIGNALING%WIKIPATHWAYS_20260510%WP3617%HOMO SAPIENS Photodynamic therapy induced NF kB survival signaling MMP9 IL2 REL IL6 SELE ICAM1 PTGS2-2 CCND1 IL1B BIRC2 CXCL8 BCL2A1 MMP1 IKBKB EGLN2 CSF2 VEGFA BIRC5 NFKB2 CHUK BIRC3 TRAF6 CXCL2;CXCL3;CXCL1-1 NFKB1 CD40LG IL1A TNFRSF1A MMP3 RELB RELA TNF VCAM1 MMP2 CFLAR BCL2L2 CYTOSINE METHYLATION%WIKIPATHWAYS_20260510%WP3585%HOMO SAPIENS Cytosine methylation TET2 MBD3 DNMT1 TET1 TDG IDH1 IDH2 MECP2 COMMON PATHWAYS UNDERLYING DRUG ADDICTION%WIKIPATHWAYS_20260510%WP2636%HOMO SAPIENS Common pathways underlying drug addiction PPP1R1A ARAF ACTG1 ACTC1;ACTG2 CAMK2A PPP1CB PPP1CA ADCY1 ADCY8 DRD4 GNAI1 MAPK1 PRKACB-1 RAF1 GJB1 GRIN2A CREB1 GRIA1 GRIA2 GRM1 GRM5 RAP1A GRIA3 CALM1 RAP1B CAMK4 MAP2K2;MAP2K1 PRKCG GRIN1 PPP1CC MAPK3 PRKCB DRD1 PRKCA ACTB-1 PRKACA-1 DRD2 GRIA4 GNAS-1 EPITHELIAL TO MESENCHYMAL TRANSITION IN COLORECTAL CANCER%WIKIPATHWAYS_20260510%WP4239%HOMO SAPIENS Epithelial to mesenchymal transition in colorectal cancer SUZ12 TGFBR2 EED CTNNB1 NOTCH2 NOTCH1 EZH2 SPARC COL4A2 PIK3CA TRAF6 CLDN6 MAPK1 RAF1 NR2C2 SMAD2;SMAD3 MAP2K6 TGFB2 SMAD4 TGFB3 MAP2K3 CLDN7 ITGA5 LATS2 MMP2 MMP9 TWIST2 TUSC3 PDCD6 CLDN2 CDKL2 CLDN3 CLDN9 FOXM1 FMNL2 CLDN8 PKP1 DSP EIF5A2 CLDN23-1 CLDN20 CLDN22;CLDN24-1 CLDN10 CLDN15 CLDN14 PKP2 CLDN12 CLDN19 STRAP NRP2 CLDN18 CLDN17 CLDN16 TMPRSS4 GDF15 NUBPL CRB3 ID1 FN1 MAPK13 CLDN5 NOTCH3 NOTCH4 WNT4 PIK3CD PIK3CB CLDN1 AKT2 AKT3 HRAS MMP15 JAG1 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 MAPK12 MEF2D MAPK11 SOS1 SOS2 TP53 CLDN11 LRP5 LRP6 WNT1 ID2-1 FZD6 CTDSP1 VTN PROX1 KRAS GRB2 SHC1-1 GSK3B MAP2K4 JAG2 CDH1 DLL1 TGFBR1-1 WNT2B FZD10 DLL3 AKT1 DLL4 OCLN-1 PKD1 WNT5B WNT9B CLDN4 WNT9A WNT16 PIK3R3 WNT8A PIK3R2 WNT8B PIK3R1 WNT6 WNT11 WNT2 PAK1 CDH2 WNT3 WNT10B WNT10A RBPJ FZD3 HIF1A FZD2 FZD5 FZD4 DLK1 WNT3A WNT7B FZD7 FZD9 WNT7A FZD8 MAPK8 MPP5 FZD1 MAP2K2;MAP2K1 WNT5A FOXC2 MAPK3 TGFB1 ZEB2 SNAI1 ZEB1 JUP SNAI2 MAPK14 TJP1 FOXQ1 RBBP4 MITOCHONDRIAL COMPLEX II ASSEMBLY%WIKIPATHWAYS_20260510%WP4920%HOMO SAPIENS Mitochondrial complex II assembly SDHAF3 SDHB SDHAF1 SDHAF4 SDHC SDHD SDHA SDHAF2 EFFECT OF INTESTINAL MICROBIOME ON ANTICOAGULANT RESPONSE OF VITAMIN K ANTAGONISTS%WIKIPATHWAYS_20260510%WP5273%HOMO SAPIENS Effect of intestinal microbiome on anticoagulant response of vitamin K antagonists CYP2C9;CYP2C19 NR1I2 VDR CD36 PPARA PPARD NPC1L1 SCARB1 PROTEASOME DEGRADATION%WIKIPATHWAYS_20260510%WP183%HOMO SAPIENS Proteasome degradation PSMD8 PSMD7 PSMD2 PSMB8 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E UCHL1 PSMB9 UBE2D3;UBE2D2 PSMC6 PSMC4 PSMD12 PSMD13 PSMD9 PSMD6 PSMD4 PSMD3 PSMD1 PSMC2-1 UBE2D3-1 PSMA5 PSMA6 PSMA3 PSMA1 PSMA7 UBA7 PSMB6 PSMB7 NEDD4 PSMB4 PSMB5 PSMB2 PSMB3 H2AZ2;H2AZ1 PSMB1 PSMA2-1 PSMC5 PSMC3 PSMC1 UBA1 IFNG UBE2D1 PSMD5 PSMD11 H2AC4 UCHL3 PSME3 PSME1 PSME2 PSMD10 RPN2 RPN1 PSMB10 UBE2B PSMA4 UBB;UBC GIP AND GLP 1 FUNCTION BY TISSUE%WIKIPATHWAYS_20260510%WP5509%HOMO SAPIENS GIP and GLP 1 function by tissue GCG GIP MIR TARGETED GENES IN LYMPHOCYTES%WIKIPATHWAYS_20260510%WP2004%HOMO SAPIENS miR targeted genes in lymphocytes CDKN2A PEDS1-UBE2V1;PEDS1 ARID1A CDK6 ABCF2-H2BE1;ABCF2 EZH2 COL4A2 MAP3K8 IGF2R BDNF TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A DNAJB1 ATAD3A;ATAD3B SLC12A2 CYP51A1 FXR2 CYP1B1 PURA ATP2A2 SMAD1 YWHAQ ITGA2 KCNQ1 CLDN1 GAS2L1 NCOA3 RAB27B GNAI2 ANXA2 ANPEP LAMTOR3 HIPK3 PICALM MBNL1 CHAF1A SPTLC1 SDCBP ATG3 CAP1 PRKCI DNMT3B DNMT3A MTHFD2 PTPRF RHOG AXL MAPK7 IGF2BP1 MAPK14 BCL2 CTNNB1 ARL10 TPM2 TMED2-1 PDLIM7 HMOX1 PGM1 TXNRD1 MAT2A TM6SF1 SPCS3 MYLIP USP1 GSTM4 RAB23 TPM3 CDKN1A LPL ELOVL5 FBXW11 CCND1 FADS2 FADS1 IDH1 SUCLG2 KIT LAMC2 MET EGFR NT5C3A BCKDHB PTBP1 RHEB KRAS PKM G6PD RHOB BACE1 E2F1 E2F3 PPP5C CDKN1B ATAT1 SLC25A13 VCAM1 TCL1A CXCL12 ANAPC1 NF2 PLAG1 UHRF1 CSNK1D MYO1E MTRR PLK1 CDKN1C RDH10 SMC1A SLC38A2 GYS1 AURKB SNAP23 PRIM1 TYMS POLD2 HDAC4 GPD2 RRP8 HOXA5 PPP1R7 GTPBP3 PKN2 OTULINL SH3BP4 CEP72 VTI1B ATG9A FERMT2 HOXD8 VAMP3 TAF9B CBFB TRMT1 TMEM59 LY6K MSI2 ABHD11 THEM4 SIGMAR1 SLC25A22 NPR3-1 DHX57 ARFIP2 ARFIP1 HARS1 BRI3BP RCOR1 MEOX2 MRPS33 MTX1 YIF1B TRIP13 IRS1 GEMIN2 NARS1 ARID2 TRPV6 UBE2S UTP15 MARS2 AP2A1 RBM19 MCL1 MAPK12 LAMC1 PGRMC1 POLR2C TUBA1A SRSF9 TMED10 NCL-1 CEBPB NRP1 CHD1 HNRNPM WNT5A ZEB1 DHX15 PPP2R5C ACAA2 SERPINE2 PLXND1 TUSC2 PRPF40A PTBP2 C1orf56 ARID4B ARF4-1 DCAF7 TGFBR2 TXN2 ARHGDIA CHORDC1 CDK5RAP1 CDK5RAP3 VPS39 NOTCH2 IFRD1 NOTCH1 GOLGA7-1 PISD RAB34 TERT WDFY1 PPIF MATR3 EIF4E DDX5 RAB5C SLC1A4 ADIPOR2 RTN4 CORO1C MRPL20 SRSF10 CPNE8 RAB6A VEZT SAC3D1 SRPRB-1 BACH1 MPDU1 PWP1 ATP6V1F RAVER2 ATP6V0A1 ANKFY1 SNX6 MYB CD164 CIAO2A PHC2 SEC62 CCN1 TBCA TMEM41B-1 TNFSF9 CACNA2D1 SFXN1 FNDC3B SLC25A1 FNDC3A TRAM1 SCAMP1 ADPGK DHX40 TNFAIP2 CARHSP1 ADAR METTL7A-1 LMNB2 WDR82 FAR1 MRC2 TMEM43 HACD3 CSRP1 UBE2J1 TMED3 COMMD9 TMEM109 GRPEL2 SH3BGRL3 EHMT2 ACP2 ATP6V1C1 MOV10 NELFCD NCEH1 CTSC PDE3A SCYL1 STRN GAK SLC7A6 ANP32B EHMT1 GFM1 CDCP1 PTPRJ POM121;POM121C MAGT1 RFT1 PANX1 FRG1 PTRH1 COIL C1QBP PNP-1 BRPF3-1 UNC93B1 GNL3L-1 GNPNAT1 CAPG TMED7 PTPA MRPS24 SHOC2 ELMOD2 CDIPT AP3B1 SEC24A CSDE1 AP3D1 PXDN ARCN1 FGF2 WDR11 AGO3;AGO1 PTMA FMNL2 PAFAH1B2 ATP6V0E2;ATP6V0E1 AMIGO2 PSAT1 NAPG NT5E MPZL1 SPRYD4 TTC9C TPPP3 GPAM NFIA NEDD4 SNX15 NUCB1 LAMTOR5 LTN1 CPOX LCLAT1 IPO4 ABHD10 POGLUT3 KPNA3 SLC38A1 RARS1 TPM4 ATRX TPM1 STX7 AKAP8 UBE4A CDKAL1 RAB30 DMTF1 MYCN SYPL1 GEMIN7 ASH2L ABCG2 RAI14 UAP1 SLC9A3R2 GFPT1 SLC4A10 CHMP2A CALCOCO2 DOCK7 SYNE2 SYNE1 HSDL1 RCN2 RBMS1 MTPN SEC23A LUZP1 NUFIP2 NXN HSD17B12 RAD23B CAND1 TDG TP53INP1 LRRC8A ZNF622 SLC25A24 IQGAP3 GALNT7 SLC12A4 MYO10 CUL4B GALNT1 SLC4A7 PDCD4 SLC25A32 NAA15 BET1 POLE4 POLA2 GNA13 P4HA2 SSNA1 PPIB BCL6 PDLIM5 CNOT9 DOCK5 SNAP29 PPP3CA KCNN4 CLOCK PPP3R1 RB1 TRANSCRIPTION FACTORS REGULATE MIRNAS RELATED TO CARDIAC HYPERTROPHY%WIKIPATHWAYS_20260510%WP1559%HOMO SAPIENS Transcription factors regulate miRNAs related to cardiac hypertrophy RASGRF1 MYEF2 AKT1 PPP3R1 TGFB1 STAT3 AKT2 NFKB1 S1P RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20260510%WP26%HOMO SAPIENS S1P receptor signal transduction PLCB3 SMPD2 AKT2 AKT3 S1PR5 SPHK2 PLCB1 GNAI3 AKT1 PIK3C2B GNAI1 GNAI2 MAPK1 MAPK6 MAPK4 MAPK12 ASAH1 RACGAP1 PLCB2 S1PR1 S1PR3 MAPK7 S1PR2 MAPK3 SPHK1 CELL DIFFERENTIATION EXPANDED INDEX%WIKIPATHWAYS_20260510%WP2023%HOMO SAPIENS Cell differentiation expanded index SOX2 MEF2D KLF4 MYOD1 MEF2C SRF MEF2B;BORCS8-MEF2B EZH2 ID2-1 HDAC5 RUNX2 MEF2A LEFTY2;LEFTY1 TLX3 TLX2 TLX1 STAT3 PAX7 IL17 SIGNALING%WIKIPATHWAYS_20260510%WP2112%HOMO SAPIENS IL17 signaling IL17D TRAF3 IL17C CEBPD TRAF3IP2 SP1 GSK3B NFKBIB JAK2 IKBKB AKT1 IL17RE PIK3CA IL17RB TRAF6 MAPK1 IL17RA IKBKG MAP3K14 NFKB1 IL17RC IL17RD CEBPB RELA JAK1 IL17B MAP3K7 IL25 MAPK3 IL17F IL17A STAT3 MIR 517 RELATIONSHIP WITH ARCN1 AND USP1%WIKIPATHWAYS_20260510%WP3596%HOMO SAPIENS miR 517 relationship with ARCN1 and USP1 ID2-1 ID1 ARCN1 USP1 CDKN1A EICOSANOID SYNTHESIS%WIKIPATHWAYS_20260510%WP167%HOMO SAPIENS Eicosanoid synthesis DPEP1 GGT1 ALOX15 ALOX12 PTGS2-2 PTGS1 PLA2G6 PTGIS TBXAS1 LTC4S PLA2G4A ALOX5AP LTA4H CBR1-1 ALOX5 PTGES PLA2G5 PTGDS PTGES2 PRXL2B ALOX15B JMJD7-PLA2G4B;PLA2G4B PHOSPHODIESTERASES IN NEURONAL FUNCTION%WIKIPATHWAYS_20260510%WP4222%HOMO SAPIENS Phosphodiesterases in neuronal function ADORA2A GRIN2C CAMK2A ADCY4 ADCY3 ADCY2 GUCY1B1 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PDE3B PDE12 PDE9A PDE11A PDE6C PDE6H PDE2A PDE10A GRIA1 GRIN2D GRIN2B GRIN1 PDE3A GUCY1A2 GUCY1A1 ADCY9 NOS1 PDE6B PDE6A PDE6D PPP1R1B PDE5A PDE4B PDE4A PDE8B PDE8A PDE4C CREB1 GRIN2A PDE1C PDE1B PDE1A PDE4D-1 PDE7B PDE7A CHRNA7;CHRFAM7A ADCY10 PRKG1 DRD1 PRKACA-1 DRD2 NAD METABOLISM%WIKIPATHWAYS_20260510%WP3644%HOMO SAPIENS NAD metabolism NADK NMNAT3 NRK SIRT4 SIRT5 NMNAT1 NMNAT2 SIRT1 CD38 SIRT2 NT5E SIRT3 NAMPT PARP1 SIRT6 GENETIC CAUSES OF PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260510%WP5269%HOMO SAPIENS Genetic causes of porto sinusoidal vascular disease NCF1 NCF2 KCNN3 NCF4 SP1 CYBB DGUOK CYBA NOTCH1 RAC1 DLL4 ESR1 CDC42 MAPK1 NFKB1 TLR9 DOCK6 CYBC1 COX4I2 RBPJ CXXC5 CHCHD2 C4orf54 BEND6 GTF2I EFL1 SHCBP1 ARHGAP31 IBTK EIF6 EOGT TLR8 SBDS NOX3 BTK MAPK3 NOTCH4 4 HYDROXYTAMOXIFEN DEXAMETHASONE AND RETINOIC ACIDS REGULATION OF P27 EXPRESSION%WIKIPATHWAYS_20260510%WP3879%HOMO SAPIENS 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression PIK3R1 EIF4EBP1 PIK3CD PIK3CB MAP2K3 PRKAA1 MAP2K2;MAP2K1 AKT1 EIF4E MAP3K11 MAPK3 TSC2 TSC1 PIK3CA MAP3K5 MAPK1 MTOR PBK RAF1 PIK3R3 MKNK1 PIK3R2 MKNK2 MAP2K6 AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20260510%WP699%HOMO SAPIENS Aflatoxin B1 metabolism CYP1A2 AKR7A2 AKR7A3 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 EPHX1 CYP2A13;CYP2A6;CYP2A7-1 GSTM1;GSTM2-1 LEPTIN INSULIN SIGNALING OVERLAP%WIKIPATHWAYS_20260510%WP3935%HOMO SAPIENS Leptin insulin signaling overlap LEP PIK3CG DGKZ SOCS2 SOCS3 IRS2 IRS1 PDPK1 JAK2 SOCS1 AKT1 IRS4 INSR INS;INS-IGF2 STAT3 PIK3R3 LEPR SARS COV 2 AND ACE2 RECEPTOR MOLECULAR MECHANISMS%WIKIPATHWAYS_20260510%WP4883%HOMO SAPIENS SARS CoV 2 and ACE2 receptor molecular mechanisms ACE2 AGTR1 MAS1 REN ACE TMPRSS2 AGT ENDODERM DIFFERENTIATION%WIKIPATHWAYS_20260510%WP2853%HOMO SAPIENS Endoderm differentiation SOX2 RARG SESN1 NLK CTNNB1 TCF4 NOTCH1 POU5F1;POU5F1B EZH2 NKX2-1 FOXA1 NODAL TCF7L1 SMAD2;SMAD3 ZBTB17 PBX1 DUSP5 SMAD4 NANOG;NANOGP8 WWC1 MAP2K3 PLCH1 C1QBP ASCC3 TET1 VAV3 AEBP2 MAD2L2 DUSP2 ELK4 HPRT1 SIAH2 CTBP2 BCORL1 FOXA2 PBX3 DKK1 SFRP1 NME1 CAND1 GATA6 TCF7 CUL4B ZFHX4 NAA15 HOXC11 PIAS1 ELAVL1 HNF1B FOXO1-1 LHX1 BMP7 PAX3 TOX3 BMPR1A CEBPZ LEF1 RGS10 STAT1 LAMC1 SOX17 SOX21 CEP250 CER1 LRPPRC DIP2A JARID2 SOX7 WDHD1 SFMBT1 ZNF281 CDYL EMSY RFX7 RAB38 APC MIXL1 WDFY2 CTR9 PRDM14 RTF1 MBTD1 EPB41L5 UBR5 BPTF ATP8B2 FOXN3 GATA4 GDF3 TRERF1 DAB2 HOXA1 SP4 NABP2 PAF1 TAF4B TRIM71 ONECUT1 NCAPG2 PHF6 CDC73 APP HHEX PABPC1;PABPC3 TRIM5 EOMES EXT1 ZIC3 DUSP4 PARP8 NOG DDAH1 FOXH1 TOX PAX9 AHDC1 BTAF1 LEO1 WNT8A KDM4A ZNF462 ELP4 TNRC6C TAF5 CRTC1 WNT3 DNMT3B ACACA MTF2 TBX21 NR3C1 GRHL2 OTX2 TGFB1 SLC2A12 GLI2 PTHLH IL19 SIGNALING%WIKIPATHWAYS_20260510%WP5422%HOMO SAPIENS IL19 signaling SOCS5 MMP1 RAC1 IL20RA IL20RB AKT1 CCNB1 MAPK1 CCL11 IL4R NFKB1 IL19 MUC5AC ACTA2 TNFRSF1A JAK1 STAT6 CXCR4 COL1A1 MAPK8 STAT1 IL4 TNF SOCS1 MAPK3 TGFB1 STAT3 MAPK14 ETHANOL EFFECTS ON HISTONE MODIFICATIONS%WIKIPATHWAYS_20260510%WP3996%HOMO SAPIENS Ethanol effects on histone modifications HDAC2 CYP2E1 HDAC1 SLC19A1 ATF2 ALDH1A2 HDAC9 KAT2B DHFR2;DHFR MTR-1 HDAC7 HDAC8 TYMS ALDH1A3 HDAC4 MTHFR MAT1A HDAC6 AHCY EHMT2 HDAC5 ACSS2 HDAC3 HAT1 ELP3 HDAC10 ADH1C;ADH1B;ADH1A ALDH2 ALDH1A1 TYROSINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260510%WP4506%HOMO SAPIENS Tyrosine metabolism and related disorders HGD TAT FAH HPD GSTZ1 GLP 1 IN PANCREATIC ISLET CELLS%WIKIPATHWAYS_20260510%WP5447%HOMO SAPIENS GLP 1 in pancreatic islet cells GCG IL6 IL6R INS;INS-IGF2 GLP1R SLC2A1 SLC2A2 CLASSICAL PATHWAY OF STEROIDOGENESIS WITH GLUCOCORTICOID AND MINERALOCORTICOID METABOLISM%WIKIPATHWAYS_20260510%WP4523%HOMO SAPIENS Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism POR CYP21A2 HSD3B1;HSD3B2 STAR CYP11B1;CYP11B2 CYP17A1 CYB5A H6PD HSD11B1 HSD11B2 HSD17B3 CYP11A1 SRD5A2 CYP19A1 TELOMERE END PACKAGING AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260510%WP5567%HOMO SAPIENS Telomere end packaging and neurodevelopmental disorders H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H4C1 H2BC5 H4C6 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 TERF2IP H2AB2;H2AB3;H2AB1 H2BC1 H4-16 H2BC15;H2BC3;H2BC11;H2BC12 H2AC20 ACD TINF2 POT1 TERF1-1 H2AC14 H2BC21 TPP1 H2AZ2;H2AZ1 TERF2 CARDIAC HYPERTROPHIC RESPONSE%WIKIPATHWAYS_20260510%WP2795%HOMO SAPIENS Cardiac hypertrophic response NFATC2 MAP4K1 CAMK2D AKT2 IKBKB MAP3K1 CHUK MAPK1 IKBKG RAF1 MAP3K14 NFKB1 HDAC7 MAP2K6 NPPA MAP2K3 CDK7 MAP2K5 CDK9 MAP3K7 TNF MEF2A PRKCA MTOR IKBKE PRKD1 FGFR2 FGF2 IGF1 GSK3B MAP2K4 PDPK1 TGFBR1-1 RAC1 NRG1 AKT1 HDAC9 PPP3CA MAP2K7 TNFRSF1A EGF HDAC4 CALM1 LOC118142757;GUCA1A PLA2G2A-1 MAPK8 MAP2K2;MAP2K1 PRKG1 HDAC5 MAPK7 MAPK3 TGFB1 MAPK14 HSPB3 IN CHARCOT MARIE TOOTH DISEASE%WIKIPATHWAYS_20260510%WP5524%HOMO SAPIENS HSPB3 in Charcot Marie Tooth disease MYOD1 HSPB2 MEF2C DMPK LMNA HP1BP3 HSPB3 ACTA1 NOTCH3 LMNB1 LBR DES CBX5 H2AZ2;H2AZ1 MYOG AMINO ACID METABOLISM PATHWAY EXCERPT HISTIDINE CATABOLISM EXTENSION%WIKIPATHWAYS_20260510%WP4661%HOMO SAPIENS Amino acid metabolism pathway excerpt histidine catabolism extension GLUD1;GLUD2 HAL UROC1 AMDHD1 FTCD GPT2 RUBINSTEIN TAYBI SYNDROME 1%WIKIPATHWAYS_20260510%WP5367%HOMO SAPIENS Rubinstein Taybi syndrome 1 PCNA CREB1 SMAD4 MAFG CLOCK ARNTL POLR1E CREBBP NCOA3 NPAS2 DDX21 FOXO1-1 FBL IRF2 ALX1 MET IN TYPE 1 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260510%WP4205%HOMO SAPIENS MET in type 1 papillary renal cell carcinoma HGF PIK3CD PIK3CB RAPGEF1 AKT2 PRCC AKT3 KDR HRAS ETS1 JUN VEGFA TFE3 PIK3CA CDC42 MAPK1 RAF1 ELOA SOS1 SOS2 MET SRC RAP1A JAK3 STRN RPL11 STAT3 KRAS GRB2 ALK BUB1B-PAK6;PAK6 ARAF CRKL GAB1 RAC1 AKT1 CRK PIK3R3 CBL PIK3R2 PIK3R1 NRAS PAK1 PAK3 PAK2 PAK5 PAK4 BAD PTPN11 RAP1B INSL3 MAPK8 MAP2K2;MAP2K1 PLCG1 MAPK3 C8orf34 BRAF CDKN1A PTK2 EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP581%HOMO SAPIENS EPO receptor signaling GRB2 PIK3CG SHC1-1 RASA1 IRS2 IRS1 JAK2 AKT1 CISH MAPK1 RAF1 EPO EPOR SOS1 PTPRC SRC PDK1 STAT5A STAT5B STAT1 MAP2K2;MAP2K1 SOCS1 MAPK3 STAT3 PTPRU FLUOROPYRIMIDINE ACTIVITY%WIKIPATHWAYS_20260510%WP1601%HOMO SAPIENS Fluoropyrimidine activity TDG SLC29A1 ERCC2 PPAT UCK1 DHFR2;DHFR RRM2-1 TYMS TP53 SLC22A7 CES2 CES1 DPYS MTHFR ABCG2 RRM1 UPB1 TYMP ABCC3 SMUG1 ABCC4 CDA DPYD UPP1 TK1 UMPS XRCC3 ABCC5 CYP2A13;CYP2A6;CYP2A7-1 FPGS GGH PDGF PATHWAY%WIKIPATHWAYS_20260510%WP2526%HOMO SAPIENS PDGF pathway GRB2 ARFIP2 SHC1-1 RASA1 VAV1 SRF ELK1 MAP2K4 WASL RAC1 HRAS PDGFRB VAV2 NFKBIA JUN MAP3K1 CHUK CDC42 MAPK1 RAF1 FOS NFKB1 RHOA PDGFB PIK3R1 SOS1 PAK1 SRC JAK1 PTPN11 PDGFA TIAM1 MAPK8 STAT1 MAP2K2;MAP2K1 PLCG1 MAPK3 PLA2G4A STAT3 ATOPIC DERMATITIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260510%WP5538%HOMO SAPIENS Atopic dermatitis mechanism and therapies IL1RL1 DEFB103A;DEFB103B MS4A2 CRLF2 IL5 FCER1G IL13 IL2RG STAT6 JAK3 IL4 OSMR IL25 IL13RA1 IL33 FCER1A TSLP STAT3 IL4R TYK2 IL31RA SOMATIC SEX DETERMINATION%WIKIPATHWAYS_20260510%WP4814%HOMO SAPIENS Somatic sex determination NR5A1 SOX9 ZFPM2 SOX8 SRY GATA4 CTNNB1 DHH RSPO1 FGF9 DMRT1 AMH WT1 PTGDS FOXL2 WNT4 B CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP23%HOMO SAPIENS B cell receptor signaling NFATC3 KLF11 PIK3CG LAT2 FYN DAPP1 SH3BP2 NFATC2 PTPN18 ATF2 MAP4K1 PIK3AP1 VAV1 MYC RAPGEF1 PTPN6 CAMK2A HRAS IKBKB VAV2 ETS1 NFKBIA JUN CHUK FOXO1-1 CDC42 MAPK1 IKBKG RAF1 CARD11 BCL10 MALT1 MAPK4 NFKB1 BLNK RASGRP3 MAP2K6 CD79B SOS1 CD79A PTPRC GSK3A CD22 GTF2I LYN MAP3K7 SYK BTK RPS6KA1 PRKCB GAB2 PRKCD INPP5D TEC REL BCL6 GRB2 CD81 SHC1-1 GSK3B CRKL NCK1 ELK1 PDPK1 CD19 GAB1 RAC1 CR2 AKT1 CRK CBL PIK3R2 HCLS1 PIK3R1 CREB1 LCK BLK PIP5K1A PIP5K1B PIP5K1C RELA PTPN11 MAPK9 MAPK8 MAP2K2;MAP2K1 PLCG2 PLCG1 MAX BRAF MAPK14 METABOLIC REPROGRAMMING IN PANCREATIC CANCER%WIKIPATHWAYS_20260510%WP5220%HOMO SAPIENS Metabolic reprogramming in pancreatic cancer HK1 LDHA GLUD1;GLUD2 KRAS GNPNAT1 RPIA PKM BCKDHA LDLR SLC7A5 GOT1-1 GOT2-1 SLC43A1 SLC16A4 RPE;RPEL1 HK2 FASN SLC16A1 PDHA1 MDH1 PFKL CS ACLY DLAT SOAT1 TP53 PDHX GLS2 UAP1 CARM1 GFPT1 SLC1A5 PDHB ME1 HMGCS2 PGM3 GPI HMGCR SLC2A1 GPT DLD BCAT2 IL7 SIGNALING%WIKIPATHWAYS_20260510%WP205%HOMO SAPIENS IL7 signaling PIK3R1 IL7R FYN BAD JAK1 STAT5A GSK3B IL2RG STAT5B PTK2B JAK3 STAT1 MAP2K2;MAP2K1 IL7 AKT1 MAPK3 STAT3 MAPK1 PIK3R2 LIPID PARTICLES COMPOSITION%WIKIPATHWAYS_20260510%WP3601%HOMO SAPIENS Lipid particles composition LPL LCAT LDLR APOC2 APOE APOA2 APOA1 APOC3 CETP APOB 1Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP4905%HOMO SAPIENS 1q21 1 copy number variation syndrome TJP3 TJP2 AFDN CTNNB1 PRKAA1 F11R AMELY;AMELX ACP6 CHD1L PYGO2 KIRREL1 OCLN-1 PYGO1 PRKAB2 PRKAB1 PRKAA2 GJA1 GJA3 GJA5 GJA8 PRKAG1 PRKAG2 PRKAG3 FMO5 BCL9 TJP1 MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20260510%WP129%HOMO SAPIENS Matrix metalloproteinases MMP9 MMP21 MMP20 MMP25 MMP12 MMP24 MMP27 TIMP3 MMP10 MMP11 MMP1 TIMP1 MMP16 TCF20 BSG MMP15 TIMP4 MMP17 MMP19 MMP7 MMP13 MMP28 MMP3 MMP8 MMP23B TNF TIMP2 MMP14 MMP2 LIVER X RECEPTOR PATHWAY%WIKIPATHWAYS_20260510%WP2874%HOMO SAPIENS Liver X receptor pathway SCD SREBF1 CYP2B6 FASN CYP7A1 RXRA CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 NR1H3 ABCG8 ABCG5 SPLICING FACTOR NOVA REGULATED SYNAPTIC PROTEINS%WIKIPATHWAYS_20260510%WP4148%HOMO SAPIENS Splicing factor NOVA regulated synaptic proteins CADM1 GABBR2 ANK3 TERF2IP GPHN SNW1 CASK EPB41 PRKCZ AGRN CLSTN1 RAP1GAP STXBP2 CHL1 EPB41L1 EPB41L2 NCDN NEO1 CLASP1 NTNG1 GRIK2 CADM3 MAPK4 APLP2 DAB1 KCNMA1 CAMK2G CDH2 KCNJ6 EFNA5 STX2 ATP2B1 PLCB4 MAPK9 KCNQ2 GRIN2B GRIN1 GABRG3;GABRG2 CAV2 CSN3 INSULIN SIGNALING%WIKIPATHWAYS_20260510%WP481%HOMO SAPIENS Insulin signaling MAP3K9 MAP3K6 GRB10 PRKAA1 IKBKB EIF4E STXBP2 JUN MAP3K1 PIK3CA MAP3K8 MAPK1 RAF1 MAP3K14 MAP4K2 MAP2K6 MINK1 RPS6KA5 STXBP3 STXBP4 RRAD PPP1R3A MAP4K3 EHD1 MAP4K4 XBP1 ARHGAP33 EHD2 MAP2K3 GRB14-1 MAP2K5 MAP3K10 RAB4A RPS6KA3 PRKCH PRKCB SGK3;C8orf44-SGK3 KIF3A PRKCD PRKCA SH2B2 GYS2 GYG1 PRKCQ MYO1C KIF5B SRF PRKCZ GYS1 RHOJ SNAP23 SGK1-1 ARF6 CYTH3 MAPK13 ENPP1 SOCS1 IRS4 CBLC RPS6KA4 INPPL1 MAP3K13 MAP3K12 FLOT1 FLOT2 RHOQ MAP4K5 PTPN1 PTEN PIK3CD PIK3CB PIK3CG IGF1R MAP4K1 RAPGEF1 AKT2 REG1B;REG1A IRS2 IRS1 PIK3C3 PIK3R4 PIK3C2G EGR1 PIK3C2A HRAS MAP3K11 TSC2 TSC1 PFKL FOXO1-1 MAPK6 MAPK4 MAPK12 MAPK11 SOS1 SNAP25 SOS2 STXBP1 GSK3A MAP3K4 FOXO3 ARF1 VAMP2 MAP3K7 TRIB3 SORBS1 RPS6KB1 RPS6KB2 RPS6KA1 INSR MTOR SLC2A1 RHEB GRB2 PFKM TBC1D4 SLC2A4 SHC1-1 CBLB GSK3B ELK1 MAP2K4 MAP3K2 PDPK1 MAP3K3 CAP1 GAB1 RAC1 AKT1 MAP3K5 CRK PRKCI SHC3 SHC2 PIK3R3 FOS CBL PIK3R2 PIK3R1 EIF4EBP1 STX4 MAP2K7 INPP4A PRKAA2 MAPK10 SOCS3 LIPE PTPN11 RPS6KA6 RPS6KA2 MAPK9 PTPRF MAPK8 MAP2K2;MAP2K1 MAPK7 MAPK3 MAPK14 VITAMIN D RECEPTOR PATHWAY%WIKIPATHWAYS_20260510%WP2877%HOMO SAPIENS Vitamin D receptor pathway KL CYP1A1 IL1RL1 PTH RASGRP1 CTLA4 LGALS9C;LGALS9;LGALS9B CYP27B1 CYP24A1 NFATC2 CDKN2A HNF1A ATP2C2 CDX2 TGFB2 MXD1 SLC8A1 MED9 LPGAT1 EFNA5 GXYLT2 ABCB1 KRTAP10-1;KRTAP10-12;KRTAP10-7;KRTAP10-6;KRTAP10-4 CDK2 STS KRT71 SLC34A2 CDC34 NINJ1 S100A4 COL13A1 KLK6 CCNC-1 CRACR2A CLEC16A CRACR2B DND1 SLC37A2 S100A6 KRTAP8-1 PNOC CLPTM1L IGSF9B CD200 BTLA ORM2;ORM1 CASP14 DUSP10 ADGRE5 DACT2 CA9 ABCD1 CAMP PRKCQ SERPINB1 SATB1 TREM1 SEMA3B CLDN2 ASAP2 CLMN CDKN2D CREG2 CDKN2B LRRC25 CDKN2C TNFSF4 S100G KRT13 ADAMTS5 MYO9B S100A8 TIMP3 DEFB132 ADRB2 KRTAP10-10;KRTAP10-2;KRTAP10-3;KRTAP10-11;KRTAP10-9-2 CD9 STAM IRF8 IL12A NRIP1 IGFBP1 TRPV5 IGFBP5 TPM1 CD14 ID1 CDKAL1 FGF23 PRDM1 IRF5 G0S2 IL25 ADRA1B KNG1 SFRP1 ALPG;ALPP;ALPI-1 CASP5;CASP4 DEFB4A;DEFB4B CDKN1A CYP2C9;CYP2C19 CYP2B6 BDKRB1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 TNFAIP3 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CEBPA LRRC8A CCND1 SALL4 MYC CYP2S1 ID4 HSD17B2 CST6 TRPV6 SULT1C2 IGFBP3 SPRR1A;SPRR1B TNFRSF11B FOXO1-1 TNFSF11 S100A2 BMP6 KLF4 SOSTDC1 PPARD PTGER4 ATP2B1 EPHB4 LRP5 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 CBS;CBSL BCL6 CYP7A1 RXRA THBD SLC2A4 NOX1 ITGAM G6PD STEAP4 KRT16;KRT14 JUNB COLEC11 SULT2A1-4 VDR IRF4 HIF1A DNER GADD45A CD40 SPP1 CDKN1B CCNE1 TIMP2 S100A9 TGFB1 TRAK1 ALOX5 CYP2D6;LOC107987479;LOC107987478-1 PTHLH 8P23 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP5346%HOMO SAPIENS 8p23 1 copy number variation syndrome CGAS GATA4 SLC2A4 CTNNB1 CTSB SGPL1 CLDN23-1 CSTA TERT AXIN1 PINX1 MTMR9 HEPACAM2 MTMR7 MEPE C8orf74 DEFB135 NUMA1 RP1L1 MFHAS1 MAPK1 FAM167A PPP1R3B MTMR8 RAF1 XKR6 MTMR6 HSPD1 BLK TNKS TLR4 TLR2 CTSD TBX5 MCRS1 BMP1 ERI1 SLBP TERF1-1 S100A10 MSRA NEIL2 SLC35G4;SLC35G5;SLC35G3;SLC35G6 FDFT1 MAPK3 SOX7 NKX6-1 PDX1 IRINOTECAN PATHWAY%WIKIPATHWAYS_20260510%WP229%HOMO SAPIENS Irinotecan pathway ABCC2 UGT1A1;UGT1A6 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ABCC1 BCHE CES2 CES1 ABCG2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 COMPLEMENT SYSTEM%WIKIPATHWAYS_20260510%WP2806%HOMO SAPIENS Complement system SELPLG ITGA2 SELP RPS19 SELE ICAM1 SELL F12 KLKB1 ADM CPN1 CRP GNAI3 PLAUR WAS GNAI2 ADIPOQ LRP2 CALR-1 F13A1 PROS1 C4BPA TLR2 C3AR1 LOC110384692;C4A;C4B_2;C4B ICAM2 FCN2;FCN1 SERPING1 LAMC1 MASP2 LAMB1 MASP1 CFB CFD CSNK1A1 C5AR2 CFI C5AR1 PRKCA THBS1 CFP C2 APOA1 VTN C5 C1QBP C6 FGB CLEC4M;CD209-2 FCGR3A;FCGR3B C7 FGA C9 F10 FGG PLG ALB CFH-3 C8A CD19 CR2 MBL2-1 PRNP VSIG4 CD93 IBSP CFHR1;CFHR2 FCER2 TXN APCS C1S FKBP2 FPR1 ELANE F11 PTX3 LAMA5 CD59 CD40 SPP1 CD55 GNA15 CR1L;CR1 C3-1 ITGA2B ARRB2 DCN ITGB3 PRKACA-1 CALORIC RESTRICTION AND AGING%WIKIPATHWAYS_20260510%WP4191%HOMO SAPIENS Caloric restriction and aging PRKAB2 NAMPT AKT1 TP53 PPARGC1A IGF1 MTOR SIRT1 CAFFEINE IN BLOOD VESSELS%WIKIPATHWAYS_20260510%WP5601%HOMO SAPIENS Caffeine in blood vessels ADCY9 ADORA2A PPP1R12A MYLK PPP1CB ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PDE3B PDE4B PDE4A ADORA2B ADORA3 PPP1R12C CALM3;CALM1 CALM1 CALM2 PDE4D-1 RYR2 ADRA1D PDE3A ADRA1B GUCY1A2 ADRA1A GUCY1A1 RYR3 NOS3 DISORDERS OF MITOCHONDRIAL HOMEOSTATIS DYNAMICS PROTEIN IMPORT AND QUALITY CONTROL%WIKIPATHWAYS_20260510%WP5504%HOMO SAPIENS Disorders of mitochondrial homeostatis dynamics protein import and quality control COQ5 COQ3 NPLOC4 PYCR3 SFXN4 RTN4IP1 AFG3L2 TXN2 MIPEP SACS AIFM1 MCL1 VCP-1 HSPD1 PLEK STAT2 OPA1 HTRA2 ATAD3A;ATAD3B PYCR2 C1QBP TXNRD2 MICOS13 USP9X PINK1 SLC25A46 PRKN UBXN1 CLPB OPA3 GDAP1L1 LONP1 UFD1 PMPCB PMPCA XPNPEP3 UBXN6 OXA1L PPA2 YME1L1 MICU1 SPG7 MFF TIMM50 MSTO1 PITRM1 TRAK1 MARCHF5-1 HSPA9 DNAJC19 MFN1 TIMM8A MFN2 TIMMDC1 DNM1L AGK PYCR1 CLPP TMEM126A-1 GFER TESSADORI BICKNELL VAN HAAFTEN SYNDROME VARIANTS NUCLEOSOME ASSEMBLY%WIKIPATHWAYS_20260510%WP5573%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome variants nucleosome assembly DAXX H4C1 CHAF1A ATRX H4C6 HIRA SMIM40 CHAF1B H2BC15;H2BC3;H2BC11;H2BC12 H4-16 RBBP4 NUCLEAR RECEPTORS META PATHWAY%WIKIPATHWAYS_20260510%WP2882%HOMO SAPIENS Nuclear receptors meta pathway SLC6A9 EP300 NR1I2 CUL1 MYOF CDK4 BIRC3 SLC6A1 SLC2A5 TGFB2 SLC6A11 CCL20 RGS2 CDK1 CDKN1C SMC1A DNAJB1 ACKR3-2 SREBF1 PTGES3-1 MGST1 CYP1B1 IL12B HES1 IL12A TXN CAP2 SLC39A2 SLC39A1 IGFBP1 NCOA1 SLC39A4 NQO1 SLC39A3 SERPINB2 UGT1A1;UGT1A6 AIP ARNT ALDH3A1 CDC37 AHRR GSTA3;GSTA5;GSTA1;GSTA2 CES3 IL17B B3GNT5 CYP2C9;CYP2C19 CYP2B6 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PTGS2-2 ACOX1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 EGR1 NCOA3 BHLHE40 KAT2B GSR GSTT2B;GSTT2 TNS4 GSTM1;GSTM2-1 PRDX1 GSTA3;GSTA1 GCLC FGFBP1 GCLM GGT1 NR0B2 IL11 TNF SLC27A1 CPT1A EHHADH-1 APOA2 ACAA1-1 NR1H3 APOA1 PGD APOC3 KLK15 APOA5 CYP8B1 TGFBR3 CYP7A1 FABP1 RXRA CPT2 SCP2 ACADM PPARA PLTP FTL-1 HSPA1A;HSPA1B NRG1 SLC39A9 FTH1 SLC39A6 JUNB SLC39A5 MFGE8 SLC39A8 NCOA2 SLC39A7 SLC6A19 HBEGF HSP90AA1 SLC6A18 SLC6A17 SLC6A16 TGFA SLC6A15 SLC6A14 SLC6A13 SLC5A6 SLC5A7 SLC5A8 SLC5A9 SULT2A1-4 EPHA3 SLC6A20 SLC5A2 DNER CES5A SLC5A3 SLC5A4 SLC5A5 PRDX6 SLC2A9 SLC6A5 SLC6A7 SERPINA1 SRXN1 SLC2A6 SLC6A2 SLC2A7 SLC6A4 SLC6A3 SLC2A8 ALOX5AP ME1 SLC2A11 TGFB1 JUND SLC2A10 ABCC5 SLC2A13 SNAI2 SLC2A12 SLC39A11 CYP2A13;CYP2A6;CYP2A7-1 SLC39A10 SLC39A13 CYP1A1 SLC39A12 IL2 SLC39A14 BLVRB KEAP1 SLC5A11 SLC5A12 SLC5A10 CBR3 TGFBR2 SP1 BIRC2 POU5F1;POU5F1B JUN ESR1 NFKB2 NFE2L2 PPARGC1A ABCB1 ABCB4 ABCB11 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC3 ABCC4 ABCC2 SLC10A1 BAAT CBR1-1 SLC27A5 SLC7A11 HMOX1 TXNRD3 PTPA TXNRD1 AMIGO2 SLC6A8 GPAM AKAP13 ABCG8 PDE4B PSMC5 ABCG5 NRIP1 PDGFB GSTM4 NR1I3 GSTM3 GSTP1 NCOA6 FGF19 FGF13 HSP90AB1 HGF TNFAIP3 MGST3 FKBP5 GCC1 MGST2 SEC14L1 PLK2 LRRC8A SMARCA1 CPEB4 CCND1 EPB41L4B MYC ENC1 EDN2 TSC22D3 SERPINB9 IRS2 CDC42EP3 PMP2 SCD FASN FGD4 SPRY1 SRPX2 GSTA4 AGER GPR153 SERTAD2 CAVIN2 NR1H4 KTN1 FOXO1-1 SLCO2B1 SCNN1A ANKRD1 SLC26A2 ABHD2 IP6K3 DNAJC15 ARL5B SRGN DNAJC7 PCK1 NAV3 ADGRF4 PRRG4 PPP1R14C S100P EPHA2 PPARD SRC PDK4 EGFR PTGR1-1 STAT3 CYP4F3;CYP4F2;CYP4F12;CYP4F11 SLC2A1 ZIC2 MAFG MAFF THBD ALAS1 SLC7A5 SLC2A4 SLC19A2 IL1B G6PD SLC5A1-1 SQSTM1 SLC2A2 POLK AHR SLC6A6 IFNG SOD3 VDR STOM SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 CES2 GADD45B CES1 CCL13;CCL2 BAX CDKN1B NR3C1 ETNK2 ANGPTL4 NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20260510%WP299%HOMO SAPIENS Nuclear receptors in lipid metabolism and toxicity RARG CYP2C9;CYP2C19 CYP8B1 CYP2E1 NR1I2 CYP7A1 CYP2B6 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP27B1 CYP24A1 PPARA CYP26A1 RARB NR1H4 PPARG ABCG5 RARA VDR ABCG1 ABCD2 PPARD ABCB1 ABCD3 ABCA1 ABCB4 NR1I3 ABCB11 ABCC3 ABCC2 CYP4B1 NR1H3 T CELL ACTIVATION SARS COV 2%WIKIPATHWAYS_20260510%WP5098%HOMO SAPIENS T cell activation SARS CoV 2 IL2 PTEN HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 PIK3CD RASGRP1 CTLA4 LTA FYN RPTOR DEPTOR CCND1 CDKN2A CD28 MLST8 JAK2 HRAS RICTOR IKBKB STAT4 NFKBIA GRAP2 IL12RB1 JUN IFNAR2 TSC2 CHUK TSC1 ZAP70 MAPK1 IKBKG LCP2 RAF1 CARD11 BCL10 MALT1 NFKB1 ICOS IFNAR1 CCL19 IL12RB2 SOS1 TP53 IFNB1-4 PTPRC BCL2L1 CCL28 IRF2BPL FOXO3 TNF HLA-DRA MTOR RHEB GRB2 PRKCQ MYD88 ITPR1 CD80 GSK3B IL23R PDPK1 CD3G AKT1 CD3E CD3D PPP3CC IL12B FOS TYK2 IL12A PIK3R1 IFNG IL23A LCK IL18R1 RELA BAX NFATC1 MAP2K2;MAP2K1 IL4 CD4 PLCG1 MAPK3 CD247 LAT CD86 IL17A CDKN1A PI3K AKT MTOR VITAMIN D3 SIGNALING%WIKIPATHWAYS_20260510%WP4141%HOMO SAPIENS PI3K AKT mTOR vitamin D3 signaling LDHA VDR RXRA CYP24A1 PRKAA2 PFKFB4 RELA CD80 MYC GSK3B AKT1 PDHA1 HLA-DRA TSC2 HK3 IL10 TSC1 PIK3CA CD86 MTOR IL12A ENDOMETRIAL CANCER%WIKIPATHWAYS_20260510%WP4155%HOMO SAPIENS Endometrial cancer PTEN PIK3CD PIK3CB APC2 CTNNA1 CCND1 TCF7 CTNNB1 MYC AKT2 AKT3 CTNNA3 TCF7L2 CTNNA2 AXIN1 HRAS PIK3CA ERBB2 AXIN2 MAPK1 RAF1 TCF7L1 SOS1 SOS2 TP53 FOXO3 LEF1 EGFR APC KRAS GRB2 FGFR3 FGFR2 FGF2 FGFR1 ARAF GSK3B ELK1 CASP9 PDPK1 CDH1 POLK ILK AKT1 DDB2 FOS PIK3R3 PIK3R2 PIK3R1 NRAS EGF BAK1 GADD45B BAD GADD45A GADD45G FGF1 BAX MAP2K2;MAP2K1 MAPK3 BRAF CDKN1A HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES INTERFERON INDUCTION%WIKIPATHWAYS_20260510%WP4880%HOMO SAPIENS Host pathogen interaction of human coronaviruses interferon induction MAVS IFIH1 TBK1 IKBKE TRAF3 DDX58 TICAM1 MYD88 IRF3 TLR7 IKBKB NFKBIA JUN IFNAR2 CHUK TRAF6 IKBKG EIF2AK2 OAS1 FOS TYK2 NFKB1 OAS3 IFNAR1 IRF9 RIPK1 STAT2 JAK1 MAP3K7 MAPK8 STAT1 MAPK14 CELIAC DISEASE MECHANISM AND THERAPIES%WIKIPATHWAYS_20260510%WP5562%HOMO SAPIENS Celiac disease mechanism and therapies IL2 GZMH;GZMB-1 IFNG ITGB7 F2RL1 TGM2 IL21 EGFR DHODH CD4 TNF ITGA4 IL15 TARGETING YAP IN PANCREATIC DUCTAL ADENOCARCINOMA PDAC %WIKIPATHWAYS_20260510%WP5495%HOMO SAPIENS Targeting YAP in pancreatic ductal adenocarcinoma PDAC TEAD4 SAV1 STK4 PRKAA1 RHOC RHOB RHOD RHOA CCN2 PRKAB2 PRKAB1 CCN1 PRKAA2 STK3 YAP1-1 RHO MOB1A;MOB1B PRKAG1 PRKAG2 TEAD1 LATS1 PRKAG3 TEAD2 TEAD3 LATS2 HMGCR NEURAL CREST DIFFERENTIATION%WIKIPATHWAYS_20260510%WP2064%HOMO SAPIENS Neural crest differentiation GFAP COL11A2 CTNNB1 MSX2 DVL1 NOTCH2 DVL2 TCF4 DVL3 NOTCH1 DCT AXIN1 NFKB2 TCF7L1 NFKB1 FOXD3 MYB TFAP2E;TFAP2B ISL1 MBP HAND1 HDAC11 HDAC2 HDAC1 FGF2 SOX5 FGF8 HDAC9 HES1 GJB1 ID1 CTBP2 HDAC4 ASCL1 HEY2 GBX2 SMAD1 NOTCH3 NOTCH4 FGF19 HDAC10 MYC OLIG1 PHOX2B ETS1 TBX6 ZIC1 AXIN2 LHX1 HDAC7 BMP7 PAX3 MPZ MIA HOXB1 HDAC6 DLX5 HES5 LHX2 LHX5 WNT1 DMBX1 OLIG3 PRTG PMP22 FGFR3 FGFR2 FGFR1 HOXA1 GSK3B CDH1 DLL1 DLL3 DLL4 MITF RHOB WNT8A HDAC8 SOX9 CDH2 COL2A1 RBPJ FZD3 OLIG2 SOX10 ITGB1 WNT3A NEUROG1 HDAC5 TFAP2A BMP4 HDAC3 TLX2 MSX1 SNAI1 SNAI2 PAX7 CDH7 CDH6 ID SIGNALING%WIKIPATHWAYS_20260510%WP53%HOMO SAPIENS ID signaling MYOD1 ID1 CDK2 PAX2 ELK1 PAX8 SREBF1 ELK4 RBL2 CCNE1 ID2-1 ELK3 RB1 RBL1 ID3 PAX5 16P12 2 COPY NUMBER VARIATION SYNDROME 520KB %WIKIPATHWAYS_20260510%WP5510%HOMO SAPIENS 16p12 2 copy number variation syndrome 520kb RPTOR CDR2 PRKAA1 MLST8 TRAP1 MAPK1 POLR3E MAPK12 MAPK11 PRKAB2 PRKAB1 EEF2K CDK2 CALM3;CALM1 CDK1 PRKAG1 PRKAG2 RPS6KB1 PRKAG3 RPS6KA1 RAB5IF TRPM7 PDZD9 SDR42E2 VWA3A CDH18 MTOR MOSMO-1 NDUFS8 UQCRB NDUFS3 UQCR11 COX7C UQCR10 COX5A UQCRQ UQCRC1 CYC1 UQCRC2 NDUFA4 UQCRFS1 NDUFV1 NDUFA9 PRKAA2 EEF2 CALM1 CALM2 MAP2K2;MAP2K1 MAPK13 MAPK3 MAPK14 CHROMOSOMAL AND MICROSATELLITE INSTABILITY IN COLORECTAL CANCER %WIKIPATHWAYS_20260510%WP4216%HOMO SAPIENS Chromosomal and microsatellite instability in colorectal cancer MSH2 RAC3 APC2 TGFBR2 PTGS2-2 CCND1 BCL2 TCF7 CTNNB1 MYC AKT2 AKT3 NTN1 TCF7L2 PMAIP1 AXIN1 RALA-1 BIRC5 JUN AXIN2 MAPK1 RAF1 TCF7L1 BBC3 SMAD2;SMAD3 TGFB2 SMAD4 BCL2L11 TGFB3 TP53 DCC EXOC2 RALB LEF1 CSNK1A1 APC REL KRAS TBK1 ARAF GSK3B CASP9 TGFBR1-1 RAC1 CASP3 POLK AKT1 MLH1 RALGDS DDB2 FOS RHOA MSH6 CYCS-1 BAK1 MAPK10 GADD45B BAD GADD45A GADD45G APPL1 MAPK9 BAX MAPK8 MAP2K2;MAP2K1 MAPK3 MSH3 TGFB1 BRAF CDKN1A CYSTEINE AND METHIONINE CATABOLISM%WIKIPATHWAYS_20260510%WP4504%HOMO SAPIENS Cysteine and methionine catabolism GOT1-1 ETHE1 SQOR MAT1A SUOX BHMT CDO1 MPST CTH CSAD AHCY GSS CBS;CBSL MTR-1 GCLC THYMIC STROMAL LYMPHOPOIETIN TSLP SIGNALING%WIKIPATHWAYS_20260510%WP2203%HOMO SAPIENS Thymic stromal lymphopoietin TSLP signaling CRLF2 FYN FES JAK2 YES1 STAT4 AKT1 NFKBIA HCK NFKB2 TSLP MAPK1 NFKB1 EIF4EBP1 IL7R LCK SRC RELB RELA JAK1 PTPN11 STAT5A LYN MAPK9 STAT6 STAT5B MAPK8 STAT1 MAP2K2;MAP2K1 RPS6 BTK MAPK3 GAB2 STAT3 MAPK14 TEC MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20260510%WP289%HOMO SAPIENS Myometrial relaxation and contraction pathways MYL2 OXT-1 SP1 ADM ACTC1;ACTG2 JUN GABPA NFKB1 SLC8A1 ACTA2 ATF1 RGS4 RGS5 DGKZ ATF6B RGS2 GJA1 RGS3 RGS1 CREB3 RGS9 RGS6 RGS7 ACTA1 PRKCG ATF4 PRKCH PRKCB PRKCE GUCY1A1 PRKCD PRKCA GNAS-1 CACNB3 ADCY9 PRKAR1B CALCA NOS1 PRKAR1A PRKCQ PRKD1 ITPR1 ITPR2 ACTG1 ITPR3 ACKR3-2 PRKCZ GSTO1 GRK5 PRKAR2B GRK4 PRKAR2A GRK6 SFN GNG13 PDE4B PKIB IGFBP1 GNAQ PKIA IGFBP5 GNB2 GNB1 GNB4 GNB3 GNB5 PKIG CALM1 CALM2 YWHAE PDE4D-1 RYR1 RYR2 YWHAB ATP2A3 ATP2A2 ARRB1 ARRB2 RYR3 ACTB-1 GNGT1 PRKACA-1 YWHAQ YWHAG YWHAH YWHAZ PLCB3 RAMP1 RGS18 CAMK2B RGS17 ATF2 CAMK2D RGS19 RGS14 RGS16 CAMK2A ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 IGFBP3 ADCY7 IGFBP2 ADCY6 ADCY5 PRKACB-1 GNG2 GABPB1 GNG5 GNG4 RLN2;RLN1 RGS20 GNG8 CAMK2G MYLK2 CALM3;CALM1 LPAR1 RGS10 RGS11 CRCP RXFP1 RXFP2 IGFBP4 CNN2 CALD1 IGFBP6 IL6 GPR182 MAFF RAMP2 RAMP3 CORIN GUCA2B GUCA2A IL1B ETS2 CNN1 ATF5 FOS CREB1 CRH CRHR1 ATF3 PLCD1 MYL4 OXTR PLCG2 PLCG1 NOS3 ACRYLAMIDE BIOTRANSFORMATION AND EXPOSURE BIOMARKERS%WIKIPATHWAYS_20260510%WP4233%HOMO SAPIENS Acrylamide biotransformation and exposure biomarkers CYP2E1 PERTURBATIONS TO HOST CELL AUTOPHAGY INDUCED BY SARS COV 2 PROTEINS%WIKIPATHWAYS_20260510%WP4936%HOMO SAPIENS Perturbations to host cell autophagy induced by SARS CoV 2 proteins PKM RAB7A VPS41 RPTOR PPP1R9A DEPTOR VAMP8 TAX1BP1 VPS39 SQSTM1 ATG2B RB1CC1 MLST8 ATG5 ATG3 ATG7 EIF4B AKT1 ATG12-1 LARP1-1 ATG16L1 AKT1S1 NBR1 LAMP2 ATG4A PRKAA2 ATG13 ULK1 APOB VPS18 VPS33A RPS6 LAMTOR1 OPTN-1 RPS6KB1 CALCOCO2 VPS11 VPS16 ATG9A MAP1LC3B2;MAP1LC3B-1 GABARAPL2 MTOR TMEM59 RHEB TESSADORI BICKNELL VAN HAAFTEN SYNDROME 3 OVERVIEW PATHWAY%WIKIPATHWAYS_20260510%WP5575%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome 3 overview pathway TAF2 H4C1 TBP MED23 TAF13 TAF8 MED27 LUPUS THERAPIES%WIKIPATHWAYS_20260510%WP5560%HOMO SAPIENS Lupus therapies IL6 IL17D IL17C TNFSF13B CD80 CD28 CD38 MS4A1 CD19 IL6R C1QB IL12B IL12A CD40LG IFNG IL23A CD22 LOC110384692;C4A;C4B_2;C4B CD40 IL17B C3-1 IL25 C1QC IL17F CD86 IL17A C2 TP53 NETWORK%WIKIPATHWAYS_20260510%WP1742%HOMO SAPIENS TP53 network TNFSF10 BID TP53 CDKN2A BCL2 GADD45A MDM2-2 MYC SUMO1 BAX PMAIP1 TP63 ABL1 ATM OTX2 TP73 BOK CDKN1A BBC3 SPINA BIFIDA%WIKIPATHWAYS_20260510%WP5150%HOMO SAPIENS Spina bifida AHCYL2 DNMT1 AHCY MAT2B SHMT1 DNMT3B DNMT3A MTRR MTHFR MAT1A MTHFD1 MTR-1 AMINO ACID METABOLISM%WIKIPATHWAYS_20260510%WP3925%HOMO SAPIENS Amino acid metabolism ARG1 ODC1 ASS1 SRM SMS GLUL ALDH18A1 TPH1 FH MARS2 PDHA1 MDH1 IDH1 FARSB DLST GSS SDHA GSR CS ACLY G6PC2 PC HDC OGDH GCLM MMUT PCK1 TDO2 PDHX SUCLG1 DBH HNMT PDK4 CAD P4HA2 PNMT ALDH7A1 HMGCL TPO CPS1 HIBADH GLS TAT HMGCS2 HADH EHHADH-1 AUH OTC ACAA1-1 BCAT1 CBS;CBSL HIBCH DLD LDHA GLUD1;GLUD2 PKM ACO2 ACADM GOT1-1 GOT2-1 MDH2 CTH PPM1L ADH5 ARG2 IARS1 VARS1 AOC3 ASNS WARS1 MCCC1 EPRS1 RARS1 FTCD SDS FAH ACSS1 BHMT DDC MPST TH MAOA HAL GPT2 LARS2 ADH4 ADH1C;ADH1B;ADH1A OAT PYCR1 ALDH1A1 TRYPTOPHAN KYNURENINE PATHWAY IN POST COVID SYNDROME%WIKIPATHWAYS_20260510%WP5549%HOMO SAPIENS Tryptophan kynurenine pathway in post COVID syndrome IFNG IL6 HAAO IFNB1-4 TDO2 AFMID IL1B KYAT3 GOT2-1 AADAT KYAT1 IDO2 IDO1 DDC KYNU KMO TNF AHR PKC GAMMA CALCIUM SIGNALING IN ATAXIA%WIKIPATHWAYS_20260510%WP4760%HOMO SAPIENS PKC gamma calcium signaling in ataxia PLCB3 GNAQ GRIA1 GRIA2 ATP2B2 GRM1 ITPR1 HOMER3 CACNA1A PLCB4 GRIA3 PDK1 GNA14 GNA15 PLCB1 PLCB2 PRKCG CA8 RYR3 TRPC3 GRIA4 GNA11 NANOMATERIAL INDUCED APOPTOSIS%WIKIPATHWAYS_20260510%WP2507%HOMO SAPIENS Nanomaterial induced apoptosis CASP7 CASP8 FADD BID CYCS-1 CASP6 BAK1 BCL2 ENDOG DIABLO-1 BAX CASP9 CASP3 FAS PRF1 HTRA2 AIFM1 APAF1 FASLG CFLAR BLOOD CLOTTING CASCADE%WIKIPATHWAYS_20260510%WP272%HOMO SAPIENS Blood clotting cascade FGB F9 FGA F10 FGG SERPINB2 F11 F7 VWF PLG KLK1 SERPINF2 F12 F5 F13B F8 KLKB1 F2 SERPINE1 PLAT PLAU F3 16P11 2 DISTAL DELETION SYNDROME%WIKIPATHWAYS_20260510%WP4950%HOMO SAPIENS 16p11 2 distal deletion syndrome TRAF1 PRMT1 GRB2 CD81 NFATC2 MPL KDR CD19 JAK2 CR2 VAV2 RABGEF1 NFATC2IP TUFM TRAF2 ATXN2L SPNS1 RABEP2 IFITM3;IFITM2;IFITM1 RAB5A ATP2A1 C3-1 IL4 RAB4A INSR CD82 LAT SH2B1 OVERVIEW OF PROINFLAMMATORY AND PROFIBROTIC MEDIATORS%WIKIPATHWAYS_20260510%WP5095%HOMO SAPIENS Overview of proinflammatory and profibrotic mediators IL2 CXCL10 IL3 CXCL11 CXCL12 CXCL14 LTA TNFSF13B CCL3L1;CCL3L3;CCL3;CCL18 CXCL9 IL13 CXCL17 XCL1;XCL2 MMP1 CCL23;CCL15 CXCL5;CXCL6 VEGFA PF4;PF4V1-1 CXCL2;CXCL3;CXCL1-1 CCL11 NFKB1 CCL1 CCL19 EPO CCL17 EBI3 CCL25 CCL24 CCL22 IFNB1-4 CCL21 CCL20 CCL28 PPBP CCL26 IL9 MMP9 IL1RN CSF2 CSF1 CXCL13 IL12B IL36A IL12A IL36B IL1A IL24 IL17B IL25 IL36RN IL37 IL36G IL26 IL1F10 IL17D IL17C IFNK IL5 MMP3 TNF IL11 IL18 OSM IL6 IL1B AREG CX3CL1 CCL14 CXCL8 IL21 IL22 CSF3 IL7 CCL27 IL27 CTF1 IL33 TSLP CCL16 IL20 IFNL2;IFNL3;IFNL1 LIF IL31 IFNG IL23A IL19 SPP1 CCL13;CCL2 IL4 CCL8 CCL4L2;CCL4L1;CCL4 CCL5 CNTF IL17F TGFB1 IL10 IL17A IL15 LEUKOCYTE INTRINSIC HIPPO PATHWAY FUNCTIONS%WIKIPATHWAYS_20260510%WP4542%HOMO SAPIENS Leukocyte intrinsic Hippo pathway functions LPL ITGAL NDRG1 RASSF5 TEAD4 SAV1 FOXO4 MST1 CD19 RAC1 CCR7 FOXO1-1 STK38L FOXP3 RHOA FOXO6 KNSTRN-1 RAB13 FERMT3 FYB1 FOXO3 STK3 YAP1-1 RAP1A PRDM1 MOB1A;MOB1B TEAD1 LATS1 TEAD2 TEAD3 LATS2 WWTR1 YWHAQ MAPK14 ALANINE AND ASPARTATE METABOLISM%WIKIPATHWAYS_20260510%WP106%HOMO SAPIENS Alanine and aspartate metabolism GAD1 GAD2 ASPA ASS1 DARS1 ASL GOT1-1 AGXT GOT2-1 PC ABAT GPT ENDOPLASMIC RETICULUM STRESS RESPONSE IN CORONAVIRUS INFECTION%WIKIPATHWAYS_20260510%WP4861%HOMO SAPIENS Endoplasmic reticulum stress response in coronavirus infection PPP1R10 PPP1R1A PPP1R12A PPP1R9A BCL2 PPP1R14A DDIT3 PPP1CB MAP1LC3A PPP1CA PPP1R1B PPP1R3B EIF2AK2 ATF6 ERN1 PPP1R3A MBTPS1 XBP1 PPP1R14C PPP1R15A PPP1R15B PPP1R13B PPP1R11 PPP1R12B PPP1R8;STX12 PPP1R12C PPP1R2-1 PPP1R16B PPP1R14B PPP1R16A EIF2S1 PPP1R3G PPP1R3F MBTPS2 MAPK8 PPP1R3E PPP1R1C PPP1R7 PPP1R3D PPP1R14D ATF4 PPP1CC PPP1R3C EIF2AK1 EIF2AK3 HSPA5 PENTOSE PHOSPHATE PATHWAY IN SENESCENT CELLS%WIKIPATHWAYS_20260510%WP5043%HOMO SAPIENS Pentose phosphate pathway in senescent cells RPIA PGLS TP53 DERA G6PD TALDO1 RPE;RPEL1 WNT SIGNALING IN KIDNEY DISEASE%WIKIPATHWAYS_20260510%WP4150%HOMO SAPIENS Wnt signaling in kidney disease INVS CTNNB1 DVL1 NPHP3 DVL2 DVL3 WNT2B WNT5B WNT9B WNT16 RHOA WNT6 WNT11 WNT2 WNT3 WNT10B WNT10A FZD3 FZD2 MAPK10 FZD5 FZD4 WNT3A WNT7B LRP5 FZD7 FZD9 MAPK9 LRP6 WNT7A MAPK8 WNT1 FZD8 FZD1 WNT5A FZD6 WNT4 COCAINE METABOLISM%WIKIPATHWAYS_20260510%WP2826%HOMO SAPIENS Cocaine metabolism CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 BCHE CES2 CES1 LEPTIN AND ADIPONECTIN%WIKIPATHWAYS_20260510%WP3934%HOMO SAPIENS Leptin and adiponectin LEP PRKAG1 PRKAB1 CPT1A ADIPOR2 ACACA PRKAA1 ADIPOQ LEPR ADIPOR1 LUPUS PATHOGENESIS%WIKIPATHWAYS_20260510%WP5559%HOMO SAPIENS Lupus pathogenesis TLR9 CD274 CD40LG IL6 TLR4 TNFSF13B BCR TLR7 CD40 CD80 CD28 PDCD1 TNFRSF13C CD86 IL17A LOC102723996;ICOSLG ICOS NON HOMOLOGOUS END JOINING%WIKIPATHWAYS_20260510%WP438%HOMO SAPIENS Non homologous end joining PRKDC XRCC5 XRCC6 XRCC4 LIG4 DCLRE1C POLM POLL WRN NHEJ1 EGFR TYROSINE KINASE INHIBITOR RESISTANCE%WIKIPATHWAYS_20260510%WP4806%HOMO SAPIENS EGFR tyrosine kinase inhibitor resistance HGF PTEN PIK3CD PIK3CB IGF1R RRAS2 CCND1 BCL2 EIF4E2 MYC AKT2 MRAS AKT3 KDR JAK2 IL6R HRAS PDGFRB PDGFRA EIF4E VEGFA RRAS PIK3CA ERBB2 MAPK1 RAF1 SOS1 SOS2 BCL2L11 MET BCL2L1 SRC FOXO3 JAK1 EGFR RPS6 RPS6KB1 RPS6KB2 PRKCG PRKCB PRKCA STAT3 MTOR KRAS IL6 GRB2 FGFR3 FGFR2 SHC1-1 FGF2 IGF1 ARAF GSK3B PDPK1 GAB1 NRG1 NRG2 AKT1 GAS6 SHC4 SHC3 SHC2 TGFA PIK3R3 PIK3R2 ERBB3 PDGFB PIK3R1 EIF4EBP1 NRAS EGF BAD PDGFA PDGFD PDGFC NF1 BAX MAP2K2;MAP2K1 AXL PLCG2 PLCG1 MAPK3 BRAF ROTENONE METABOLISM%WIKIPATHWAYS_20260510%WP5486%HOMO SAPIENS Rotenone metabolism CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 OMEGA 6 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260510%WP5424%HOMO SAPIENS Omega 6 fatty acids in senescence DPEP1 GPX1 ALOX15 ALOX12 ALOXE3 ELOVL5 PTGS2-2 PTGS1 ELOVL2 SERPINE1 SIRT1 FADS2 TBXAS1 FADS1 PTGES3-1 PTGES2 HPGDS PRXL2B MAPK11 GGT1 TP53 AKR1B1 SLCO2A1 ABCC4 GSTP1 PTGIS HPGD DECR1 LTC4S RB1 PLA2G4A ALOX5AP CYSLTR1 DPEP2 LTA4H CBR1-1 ALOX5 PTGES PTGDS GGT5 EPHX2 PTGR2 ALOX15B CDKN1A ALDH1A1 NETWORK MAP OF SARS COV 2 SIGNALING%WIKIPATHWAYS_20260510%WP5115%HOMO SAPIENS Network map of SARS CoV 2 signaling PRG3 CXCL10 HRG SELP CTSZ NKRF CXCL12 SDF2 GP1BA ATP13A3-1 FYN IL16 OS9 CCL3L1;CCL3L3;CCL3;CCL18 SRP72 CD8A LRG1 SRP19 CD8B;CD8B2 CLCC1 GTF2F2 PTPN6 G3BP2 PARP2 NPTX1 MDN1 NEK9 CCL23;CCL15 TRO APOL3;APOL4;APOL1;APOL2 TRIM59 ITIH3 CCR6 BIRC5 RAP1GDS1 RRAS ERLEC1 CCNB2 UGGT2 CXCR1 CCNB1 TRAF6 ATE1 CD2 IKBKG CCL11 COL7A1 CARD11 FAM98A IFIT1 CCL1 CCL22 CCL21 CCL20 CCL26 ATG13 CDK1 ULK1 G3BP1 VPS18 VPS33A ITIH4 VPS11 VPS16 MAP1LC3B2;MAP1LC3B-1 GABARAPL2 BST2 ATP6AP1 HSPA8 PRKCQ MYD88 VPS41 IFI44L CTSB INTS4 NLRP1 IL12A RRM2-1 ITCH SMAD1 LBP SMAD5 NFATC3 SIGMAR1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 PTGS2-2 TLE3 SERPINE1 TRPM2 EGR1 IGFBP3 PIAS1 ZAP70 FAM83A CASP8 IL5 BID JAK1 CAMK4 CCR5 STAT1 RPS6 TPO CFB TNF HLA-DRA NLRP3 LGALS3BP CFI TOMM70 APOA2 CFP IL18 APOA1 AGT ACE2 MAVS IL6 ITGA3 MARK2 TRAF3 CFH-3 TLE1 C8A CXCL8 CASP9 CASP3 AKT1 JUNB FOS EIF4EBP1 C1S IRF9 C1R CEBPB MAPK8 IRAK1 SRP54 GGH TGFBR2 DDIT4 IL13 CXCL9 CRP HBD;HBB CXCL5;CXCL6 EIF4E IGLL5;IGLL1 JUN NFKB2 PF4;PF4V1-1 RTN4 CXCL2;CXCL3;CXCL1-1 TRAF2 LARP1-1 IFITM3;IFITM2;IFITM1 CXCR2 TF IFNB1-4 MX1-1 TP53I3 IL9 MOV10 EIF4A2 C1QBP IFIH1 TBK1 CTSV;CTSL DDX58 IRF3 FGF2 ACTG1 UPF1 CXCL13 TNFSF10 IL18RAP IL1A CD14 APOH PMPCB FN1 PITRM1 MIB1 APOC1 CD163 ACTB-1 CASP5;CASP4 RPTOR DEPTOR MMP25 TBKBP1 CPN1 MLST8 JAK2 AKT1S1 GSN CTSD CD226 NTRK1 MTOR SAA2;SAA1 RHEB FGB FGA FGG SERPINA5 ALB IL1B IL21 IL22 IL7 RAC1 CCL27 CD3G STEAP3 IL33 AHR CD3E IFNG LCK DUSP1 SKAP1 HIF1A ADAM9 CCL13;CCL2 IL4 CCL8 CCL4L2;CCL4L1;CCL4 CCL5 CD4 IL1R2 CD247 IL10 GTSE1 IL17A VPS36 WDR74 BTN3A1;BTN3A3 APOM HP;HPR APOD HEMESYNTHESIS DEFECTS AND PORPHYRIAS%WIKIPATHWAYS_20260510%WP5169%HOMO SAPIENS Hemesynthesis defects and porphyrias ALAD ALAS2 ALAS1 FECH UROD UROS PPOX CPOX HMBS PDGFR BETA PATHWAY%WIKIPATHWAYS_20260510%WP3972%HOMO SAPIENS PDGFR beta pathway GRB2 SHC1-1 RASA1 SRF ELK1 MAP2K4 JAK2 HRAS PDGFRB JUN MAP3K1 PIK3CA EIF2AK2 RAF1 FOS PIK3R1 SOS1 JAK1 STAT5A STAT6 STAT5B MAPK8 STAT1 MAP2K2;MAP2K1 PLCG1 MAPK3 PRKCB STAT3 PRKCA GASTRIC CANCER NETWORK 1%WIKIPATHWAYS_20260510%WP2361%HOMO SAPIENS Gastric cancer network 1 RUVBL1 AURKA H3-3A H4-16 ACTL6A TOP2A NOTCH1 INO80D KIF15 ESM1 RNF216 MYBL2 UBE2C ECT2 E2F7 TPX2 SMOC2 CENPF S100P GATD3B;GATD3A KIF20B NUP107 LIN9 CCNA1 CEP192 MCM4 APC GPCRS CLASS B SECRETIN LIKE%WIKIPATHWAYS_20260510%WP334%HOMO SAPIENS GPCRs class B secretin like ADGRE5 CALCRL VIPR1 VIPR2 GLP1R GIPR CRHR1 GCGR GLP2R SCTR PTH2R CRHR2 ADCYAP1R1 ADGRE1 GHRHR ADGRG2 CALCR ADGRL4 ADGRL2 ADGRL3 ADGRL1 PTH1R PLURIPOTENT STEM CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260510%WP2848%HOMO SAPIENS Pluripotent stem cell differentiation pathway FGF10 HGF IL3 IL6 ALK FGF2 IGF1 FGF4 NOTCH1 NT5E FGF8 IL6R WNT2B VEGFA CSF1 INS;INS-IGF2 CXCR1 NOG NODAL TNFSF11 KIT PDGFB EPO WNT2 TGFB3 KITLG TF EGF CSF1R WNT3A WNT7B PDGFA FGF1 SHH WNT1 FLT3LG TPO WNT5A INHBA IL11 GDF5 CNTF LEFTY2;LEFTY1 FST BMP4 TGFB1 DKK1 NTF4 SPHINGOLIPID PATHWAY%WIKIPATHWAYS_20260510%WP1422%HOMO SAPIENS Sphingolipid pathway CERS2 SGPL1 SPTLC1 GAL3ST1 SPHK2 SGPP2 PPP1CA PLPP1 GBA GBA2 B4GALT6 CERS3 CERS4 CERS5 ASAH1 PPP2CB;PPP2CA CERS6 CERK ASAH2 SGMS1 SPTLC3 SPHK1 SGMS2 CERT1 UGT8 ACER1 UGCG SERINC1 KDSR TRANSCRIPTION CO FACTORS SKI AND SKIL PROTEIN PARTNERS%WIKIPATHWAYS_20260510%WP4533%HOMO SAPIENS Transcription co factors SKI and SKIL protein partners HDAC1 SKI TEAD4 STK3 PRMT5 MECP2 ING2 NF1 MERTK LATS1 TEAD1 SIN3A TEAD2 LATS2 TEAD3 HDAC3 SATB2 SKIL DRAVET SYNDROME%WIKIPATHWAYS_20260510%WP5200%HOMO SAPIENS Dravet syndrome SCN2B SCN1B SCN8A SCN2A SCN4B CAMK2A MLST8 MAPKAP1 SCN3B RICTOR AKT1 PIK3CA SNTA1 NFKB1 MAPK11 STXBP1 CALM1 TNF PRR5 CHD2 PRKCA PRR5L MTOR HCN1 KCNA2 PCDH19 FGF13 SCN3A SCN1A INDUCTION OF AUTOPHAGY AND TOLL LIKE RECEPTOR SIGNALING BY GRAPHENE OXIDE %WIKIPATHWAYS_20260510%WP5336%HOMO SAPIENS Induction of autophagy and toll like receptor signaling by graphene oxide TLR9 IFNG IFNB1-4 TLR4 TNF MYD88 IRF3 TRAF6 BECN1 MAP1LC3A NFKB1 MAMMARY GLAND DEVELOPMENT PUBERTY STAGE 2 OF 4%WIKIPATHWAYS_20260510%WP2814%HOMO SAPIENS Mammary gland development puberty stage 2 of 4 FOSL1 PGR EGF CCND1 AREG MYC STAT5A FN1 VIM TIMP1 ESR1 ERBB2 NRIP1 SARS CORONAVIRUS AND INNATE IMMUNITY%WIKIPATHWAYS_20260510%WP4912%HOMO SAPIENS SARS coronavirus and innate immunity ACE2 IFNAR1 MAVS IFIH1 IRF9 TBK1 TRAF3 IKBKE IFNB1-4 DDX58 STAT2 TICAM1 IRF3 TLR3 JAK1 STAT1 IFNAR2 TYK2 COMPLEMENT MEDIATED INFLAMMATION OF PULMONARY ALVEOLUS IN COVID 19 HYPOTHETICAL PATHWAY %WIKIPATHWAYS_20260510%WP5148%HOMO SAPIENS Complement mediated inflammation of pulmonary alveolus in COVID 19 hypothetical pathway ACE2 C7 C3-1 C9 MASP2 C5AR1 C3AR1 FCN2;FCN1 C8A COLEC11 C5 C6 GLP 1 FROM INTESTINE AND PANCREAS AND ROLE IN GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260510%WP5452%HOMO SAPIENS GLP 1 from intestine and pancreas and role in glucose homeostasis GCG PCSK2 INS;INS-IGF2 GLP1R PCSK1 SLC2A1 MIRNA TARGETS IN ECM AND MEMBRANE RECEPTORS%WIKIPATHWAYS_20260510%WP2911%HOMO SAPIENS miRNA targets in ECM and membrane receptors COL6A1 COL5A3 COL6A3 COL5A2 ITGA1 COL1A2 COL6A2 LAMA4 FN1 TNXB LAMB2 SDC2 COL3A1 LAMC1 COL4A2 COL4A1 ITGA11 ITGB5 ITGB6 THBS2 THBS1 COL5A1 NETRIN UNC5B SIGNALING%WIKIPATHWAYS_20260510%WP4747%HOMO SAPIENS Netrin UNC5B signaling CDH5 PPP2R1B SELE ICAM1 FYN RGMA ALPL NTN1 KDR PTK2B JUN PIK3CA ITGB4 MAPK1 NEO1 RAF1 TP53 ARHGEF12 SRC YAP1-1 TNF DAPK1-1 PRKCA INPP5D UNC5B PTPA CIP2A NTN4 AGAP2 RLF NTN3 PLEKHH1 PPP1CA RAC1 CASP3 AKT1 RHOA CCN2 IL1A PTPN11 CCL13;CCL2 COL1A1 MAP2K2;MAP2K1 MAPK3 ROBO4 IL10 VCAM1 DCSTAMP MAPK14 MYF5 PTK2 MECP2 AND ASSOCIATED RETT SYNDROME%WIKIPATHWAYS_20260510%WP3584%HOMO SAPIENS MECP2 and associated Rett syndrome TET2 PTEN FKBP5 HNRNPH1 CEBPD IGF1R SP1 UBE3A TARDBP POU3F2 MEF2C CAMK2A TAP1 EZH2 NCOR1 GPRIN1 GAD1 CDON GRIA1 MBP IGF2 BDNF DLX5 CSRP1 RPS6 GRIN1 MTOR GABRR2 HDAC1 BCL6 TET1 PSIP1 FGF2 RBFOX1 IGF1 FGF3 GRID1 MECP2 TET3 ARHGEF26 REST FGF4 MYT1 DLX6 FGF5 NREP FUT8 GAMT MPP1 PRPF38A SP3 POU4F1 SIN3A HNRNPF AKT1 TAF1 DHX9 CREB1 FUS E2F1 FOXG1 SGK1-1 GRIA3 NF1 OPRK1 CTCF APOC2 SMC3 MAG YBX1 CNP GRIA4 SST FIBRIN COMPLEMENT RECEPTOR 3 SIGNALING%WIKIPATHWAYS_20260510%WP4136%HOMO SAPIENS Fibrin complement receptor 3 signaling FGB CXCL10 REL FGA IRAK2 IL6 FGG PLG RASSF5 TICAM1 MYD88 IRF3 ITGAM ITGB2 CBLB FCER1G TLR3 TYROBP LY96 PLAT IRAK4 IKBKB AKT1 TIRAP CHUK PIK3CA TRAF6 CXCL2;CXCL3;CXCL1-1 IKBKG NOS2 IL12B NFKB1 RHOA IFNB1-4 TICAM2 TLR4 CD14 SRC RELA CCL13;CCL2 SYK TNF IRAK1 LBP INTERFERON MEDIATED SIGNALING%WIKIPATHWAYS_20260510%WP4558%HOMO SAPIENS Interferon mediated signaling PIK3R1 IFNAR1 IFNGR2 IFNG IRF9 IFNE IFNB1-4 IFNK STAT2 JAK1 STAT1 JAK2 IL10RB IFNAR2 IFNLR1 PIK3CA PRKCA IFNGR1 TYK2 IFNL2;IFNL3;IFNL1 TRANSCRIPTIONAL REGULATION OF MEMORY B CELL DIFFERENTIATION%WIKIPATHWAYS_20260510%WP5491%HOMO SAPIENS Transcriptional regulation of memory B cell differentiation TLR10 IL6 BCL6 CDKN2A TLR7 TLR3 MYC TCF4 MEF2C MEF2B;BORCS8-MEF2B EZH2 SPIB POU2AF1 IL4R LOC102723996;ICOSLG IRF8 NFKB1 TLR9 CD79B TLR6 TLR5 CD79A IRF4 E2F1 TLR4 TLR2 BCL2L1 BCR CD40 IL21R LYN STAT6 CDKN1B SYK TLR8 CCND3 TLR1 SPI1 ID3 TNFRSF13C SLAMF1 STAT3 CCND2 POU2F2 CDKN1A NICOTINE METABOLISM IN LIVER CELLS%WIKIPATHWAYS_20260510%WP1600%HOMO SAPIENS Nicotine metabolism in liver cells AOX1 CYP2B6 FMO3 CYP2A13;CYP2A6;CYP2A7-1 MODULATION OF PI3K AKT MTOR SIGNALING BY BIOACTIVE SPHINGOLIPIDS%WIKIPATHWAYS_20260510%WP5192%HOMO SAPIENS Modulation of PI3K Akt mTOR signaling by bioactive sphingolipids CERS1 IGF1R HIF1A SPHK2 S1PR1 CERK AKT1 S1PR3 ASAH2 TSC1 PIK3CA PLD1 MTOR NFKB1 FANCONI ANEMIA%WIKIPATHWAYS_20260510%WP5465%HOMO SAPIENS Fanconi anemia PTEN CEBPD ERCC4 ERCC1 MAD2L2 FAAP100 SLX4 REV1 CENPS-CORT;CORT;CENPS BRCA1 SMARCA4 UHRF1 FANCE FANCF FANCI FANCD2 RAD51C FAAP24 LOC105377022;FANCB FANCM DCLRE1B CENPX FANCL CTDP1 BRIP1 UHRF2 XRCC2 MEN1 USP1 FANCA FANCC MRE11 BRCA2 RFWD3-2 PALB2 RAD50 RAD51 UBE2T NBN ATR EGFR FAN1 FANCG ATM HSP90B1 MCM2 GPCRS OTHER%WIKIPATHWAYS_20260510%WP117%HOMO SAPIENS GPCRs other UTS2R HRH4 OR6C2;OR6C68 GPR183 OR5AC2-2 NTSR1 GPR17 ADORA2A P2RY13 P2RY11 OR2F1-2 GPR55 ADGRD1 ACKR1 LGR6 OR2A5 GPR143 GPR18 SMO CCR2 CXCR1 CCKBR CHRM2 CHRM3 CXCR2 GRM1 PTGFR EDNRA GHRHR CCR5 ADGRL2 S1PR1 ADGRL3 C5AR2 RXFP1 LTB4R2 FSHR CNR1 ADRB2 HTR2A HTR1F DRD4 F2R SSTR2 OR2M4 GPR61 GPR62 CELSR1 GRPR ADORA3 OR7E24-1 CELSR3 RXFP3 GPR176 GPR83 GPR132 OR2B6;OR2B2-1 ADGRE3 GNRHR GPR135 PROKR2 ADGRV1 ALG6 OR8G1;OR8G5 OR1F1 HTR7 OR2H1-1 TAAR5 OR1J2 TAAR2 OR1N1 GPR162 ADRA1D ADGRF5 CXCR3 OR1E1;OR1E2 VN1R1 OR6C3 OR10A5 OR3A1 GPR88 CELSR2 OR2A7;LOC107987545;OR2A4 GPR84 DRD3 MCHR2 ADGRG1 CYTOKINE CYTOKINE RECEPTOR INTERACTION%WIKIPATHWAYS_20260510%WP5473%HOMO SAPIENS Cytokine cytokine receptor interaction CXCL10 IL3 CXCL11 CXCL12 CXCL14 LTA IL2RB TNFSF13B CCL3L1;CCL3L3;CCL3;CCL18 CCR10 CCR1 LTB XCR1 XCL1;XCL2 CCL23;CCL15 CCR9 CCR8 CCR7 CCR6 CCR4 CCR2 CXCR1 CCL11 CXCR5 NFIC CXCR6 CCL1 CCL19 CD40LG TGFB2 ACVRL1 CCL25 CCL24 TGFB3 CCL22 CCL21 IL34 TNFRSF4 CCL20 CCL28 CCL26 TNFRSF18 GDF5 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A IL13RA1 BMP10 TNFRSF13B TNFSF4 ACKR3-2 PRL GDF15 TNFRSF14 TNFSF15 IL24 AMHR2 IL17B MSTN IL25 IL17D IL17C TNFSF14 GDF2 GDF1 GDF6 GDF7 CD27 RELT CD70 CLCF1 TNFRSF19 TNFRSF8 IL13RA2 IL17RB TNFRSF17 EDA2R IL17RA INHBC BMP5 INHBE FASLG ACVR1C ACKR4 BMP6 GDF9 IL5 IL5RA CSF2RB BMPR1B BMPR1A BMPR2 CCR5 PRLR TPO BMP15-1 IL11 TNF BMP3 AMH GDF10 IL18 IL6 GDF3 CX3CL1 CCL14 CXCL8 CX3CR1 IL19 NGF EDA FAS INHBA BMP4 EDAR TGFB1 CCR3 IL31RA IL2 IL1RL1 TGFBR2 IL13 CXCL9 CXCL17 CXCL5;CXCL6 IFNAR2 IL6ST PF4;PF4V1-1 LTBR CXCL2;CXCL3;CXCL1-1 NODAL GDF11 IL12RB2 IFNAR1 IFNGR2 EPO CXCR2 EPOR TNFSF9 IFNB1-4 IL3RA PPBP IL2RG IL9 IL9R ANP32B CNTFR MPL GHR IL11RA IL20RA IL1RN IL20RB IL10RB CSF2 IL10RA CSF1 IFNLR1 IL1RAP IL22RA1 CXCL13 IL36A IL36B TNFSF10 IL1R1 IL18RAP IL1A TNFRSF1A IL18R1 CSF3R IL1RL2 IL36RN TNFRSF25 IL37 TNFRSF21 IL36G IL26 IL1F10 ACVR1B IFNK TNFRSF1B IL6R IL12RB1 TNFRSF11B TNFRSF11A CSF2RA ACVR1 TNFSF11 LEPR BMP7 IL7R ACVR2B LEP INHA IL17RC CSF1R INHBB TNFRSF12A NGFR ACVR2A TNFRSF9 IL21 IL22 IL23R CSF3 IL7 TGFBR1-1 CCL27 IL27 IL33 LIFR TSLP IL27RA IL4R IL20 IFNGR1 IFNL2;IFNL3;IFNL1 LIF IL31 IFNG IL23A CD40 CCL13;CCL2 IL21R CXCR4 IL4 CCL8 CCL4L2;CCL4L1;CCL4 CCL5 IL2RA CNTF IL17F IL1R2 TNFRSF13C IL10 IL17A IL15 BMP8B PEROXIREDOXIN 2 INDUCED OVARIAN FAILURE%WIKIPATHWAYS_20260510%WP4873%HOMO SAPIENS Peroxiredoxin 2 induced ovarian failure PRDX2 CYP11A1 CASP3 HSD3B1;HSD3B2 STAR MAPK10 PARP2 BAX HYPOXIA MEDIATED EMT AND STEMNESS%WIKIPATHWAYS_20260510%WP2943%HOMO SAPIENS Hypoxia mediated EMT and stemness ZEB1 DICER1 NF KB SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260510%WP5527%HOMO SAPIENS NF kB signaling and ARTD family members EP300 MAVS TBK1 SKP1 DDX58 RBX1 GSK3B CUL1 CREBBP IKBKB NFKBIA NFKB2 CHUK BTRC TFPI2 CLDN6 IKBKG PARP1 MAP3K14 ZC3HAV1 TIPARP ERN1 PARP16 PARP12 PARP10 RELB PARP14 EIF2AK3 PARKIN UBIQUITIN PROTEASOMAL SYSTEM PATHWAY%WIKIPATHWAYS_20260510%WP2359%HOMO SAPIENS Parkin ubiquitin proteasomal system pathway PSMD8 PSMD7 PSMD2 CASK CUL1 CASP8 RNF19A HSPA14 STUB1 HSPA2 SIAH1 UBE2J1 HSPA4 CASP1 SNCA PSMC6 PSMC4 UBE2J2 PSMD12 PSMD13 HSPA8 PSMD9 PSMD6 PSMD4 PSMD3 PSMD1 PSMC2-1 TUBAL3 TUBA1C HSPA1A;HSPA1B TUBA1A TUBB1 SIAH2 TUBA3E;TUBA3C-1 UBE2L6 TUBB2B;TUBB2A GPR37 TUBB4B TUBA4A SEPTIN5 UBE2G1 UBE2G2 SNCAIP PSMC5 PSMC3 TUBB4A;TUBB;TUBB8B;TUBB8 PSMC1 UBA1 PRKN FBXW7 TUBB3;TUBB6 PSMD14 TUBA8 PSMD5 PSMD11 PSMD10 CCNE1 HSPA9 HSPA6 HSPA5 HSPA1L MACROPHAGE STIMULATING PROTEIN MSP SIGNALING%WIKIPATHWAYS_20260510%WP5353%HOMO SAPIENS Macrophage stimulating protein MSP signaling CXCL10 NR4A1 CTNNB1 CXCL5;CXCL6 JUN VEGFA CXCL2;CXCL3;CXCL1-1 MAPK1 RAF1 NFKB1 SMAD2;SMAD3 RPS6KA5 IFNB1-4 PPARGC1A ACTA2 VIM RPS6KA3 PRKCB MMP9 PCNA CSF2 FN1 CLDN5 SOCS1 SMAD1 RPS6KA4 SMAD9 SMAD5 FLT1 PTEN NDRG1 IGF1R MST1R CLDN1 MST1 HK2 KDR PDCD4 EGR1 PDGFRB PDGFRA COL4A1 NR0B2 TP53 SLPI SRC SP7 RPS6 RPS6KB1 TNF RPS6KA1 CPT1A MTOR SLC2A1 DUSP6 KLK15 LDHA IL6 GRB2 HSPB1 SHC1-1 FGFR1 IL1B CRKL GSK3B CXCL8 ELK1 CSF3 PDPK1 CDH1 GAB1 AKT1 OCLN-1 DUSP4 PARP1 FOS IBSP PIK3R1 SMAD6 CDH2 WNT10B DUSP1 PRKAA2 ITGB1 ACACA SOCS3 RELA CCL13;CCL2 MAPK9 MAPK8 FZD1 MAP2K2;MAP2K1 ABL1 PLCG1 SIX1 MAPK3 TGFB1 IL10 ZEB2 ZEB1 SNAI2 MAPK14 TJP1 PTK2 10Q22Q23 COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5402%HOMO SAPIENS 10q22q23 copy number variation ROPN1L CEBPA AFG3L2 RSPH6A SF3B4 DNAJB13 VEGFA DYDC1 PPARG RAD21 NFKB1 TNFSF11 SIRT4 SH2D4B STAG1 BUB1B ADIRF LDB3 GHITM IQUB BMPR1A FAM25A;FAM25C;FAM25G;FAM25E-1 CDHR1 DYDC2 ZMYND11 RGR NME5 SNCG SMC1A C10orf99 RSPH4A RSPH9 GPR15 SUSD2 TSPAN14 RSPH1 LRIT2 SHLD3 LRIT1 PRXL2A SHLD2 SHLD1 CCSER2 RSPH3 GLUD1;GLUD2 SH3GL3 MAS1 GRID1 MAD2L2 ACTN2 NRG3 PDS5B PDS5A ADAM10 WAPL ERBB4 MAT1A OPN4 MMRN2 SMC3 BMP2 NEPHROTIC SYNDROME%WIKIPATHWAYS_20260510%WP4758%HOMO SAPIENS Nephrotic syndrome GPC5 ALG1 ITGA3 ARHGAP24 CTLA4 SMARCAL1 CYP11B1;CYP11B2 ARHGDIA SCARB2 PTPRO CD151 SYNPO PAX2 TRPC6 LMNA WDR73 ACTN4 APOL3;APOL4;APOL1;APOL2 CD2AP INF2 MYH9 COL4A4 CUBN MYO1E WT1 COL4A3 ITGB4 PODXL NPHS1 COL4A5 PMM2 NPHS2 EMP2 PLCE1 E2F3 LAMB2 ZMPSTE24 ANLN COQ6 COQ2 PDSS2 TTC21B YARS1 LMX1B STEROID BIOSYNTHESIS%WIKIPATHWAYS_20260510%WP496%HOMO SAPIENS Steroid biosynthesis HSD3B1;HSD3B2 F13B HSD17B4 HSD17B7 CYP17A1 HSD17B3 CPN1 HSD17B1 HSD17B2 MARKERS OF KIDNEY CELL LINEAGE%WIKIPATHWAYS_20260510%WP5236%HOMO SAPIENS Markers of kidney cell lineage GDNF HNF4A FOXD1 OSR1 TCF21 NOTCH2 PAX2 NTN1 NOTCH1 SIX2 KDR ALDH1A2 RSPO3 HNF1A EGLN1 PDGFRB EGLN3 EGLN2 JAG1 SALL1 EYA1 HNF1B AP2B1 AXIN2 NPHS1 NPHS2 LHX1 FAT4 KIT BMP7 PBX1 EPO TNC ACTA2 PECAM1 CITED1 DACT1 KCTD1 TSHZ3 TBX18 REN VSX2 NT5E FGF7 FGF8 WT1 RSPO1 EMX2 WNT5A SIX1 SMAD1 BMP4 TLX1 SMAD5 DCN DES SFRP1 WNT4 TRIACYLGLYCERIDE SYNTHESIS%WIKIPATHWAYS_20260510%WP325%HOMO SAPIENS Triacylglyceride synthesis LPL LIPC GK MOGAT3 AGPAT4 MOGAT2 MOGAT1 AGPAT1 LIPE GPD1 AGPAT3 AGPAT5-1 GNPAT GK2 LIPF PLPP3 GPAM PLPP2 PLPP1 AGPS DGAT2 AGPAT2 DGAT1 PNPLA2 COVID 19 THROMBOSIS AND ANTICOAGULATION%WIKIPATHWAYS_20260510%WP4927%HOMO SAPIENS COVID 19 thrombosis and anticoagulation FGB FGA FGG F13A1 PLG F13B F2 LAC PHE PATHWAY%WIKIPATHWAYS_20260510%WP5239%HOMO SAPIENS Lac Phe pathway ABCC5 CNDP2 EICOSANOID METABOLISM VIA CYTOCHROME P450 MONOOXYGENASES PATHWAY%WIKIPATHWAYS_20260510%WP4720%HOMO SAPIENS Eicosanoid metabolism via cytochrome P450 monooxygenases pathway PPARA EPHX2 CYP4F3;CYP4F2;CYP4F12;CYP4F11 PPARG CYP2C18-1 HEPATITIS B INFECTION%WIKIPATHWAYS_20260510%WP4666%HOMO SAPIENS Hepatitis B infection EP300 TAB1 TGFBR2 NFATC2 BCL2 CREBBP IKBKB JUN BIRC5 MAP3K1 CHUK PIK3CA TRAF6 MAPK1 IKBKG RAF1 NFKB1 SMAD2;SMAD3 MAP2K6 IFNAR1 TGFB2 SMAD4 TGFB3 IFNB1-4 MAP2K3 STAT2 ATF6B CREB3L3 CREB3L4 CREB3L1 CREB3L2 JAK3 CREB3 SLC10A1 PRKCG ATF4 CREB5 PRKCB PRKCA MMP9 PCNA IFIH1 ATP6AP1 TBK1 IKBKE DDX58 TICAM1 MYD88 IRF3 IRF7 TLR3 VDAC3 EGR3 TIRAP TICAM2 YWHAB MAPK13 YWHAQ CDKN1A YWHAZ NFATC3 PIK3CD NFATC4 PIK3CB DDB1 DDX3X-1 ATF2 EGR2 MYC AKT2 AKT3 PTK2B JAK2 IRAK4 HRAS STAT4 APAF1 FASLG MAPK12 MAPK11 CASP8 SOS1 SOS2 FADD BID TLR2 SRC JAK1 STAT5A MAP3K7 STAT5B STAT1 TNF TAB2 STAT3 MAVS KRAS IL6 GRB2 TRAF3 ARAF CXCL8 CASP10 ELK1 MAP2K4 HSPG2 CASP9 TGFBR1-1 CASP3 AKT1 DDB2 PIK3R3 FOS TYK2 PIK3R2 PIK3R1 CREB1 MAP2K7 NRAS TLR4 CYCS-1 MAPK10 BAD RELA MAPK9 STAT6 BAX NFATC1 MAPK8 MAP2K2;MAP2K1 FAS IRAK1 MAPK3 TGFB1 BRAF MAPK14 DNA IR DOUBLE STRAND BREAKS AND CELLULAR RESPONSE VIA ATM%WIKIPATHWAYS_20260510%WP3959%HOMO SAPIENS DNA IR double strand breaks and cellular response via ATM CHEK1 BLM CDC25C ATF2 CDKN2A ACTL6A KAT5 BRCA1 PRKDC TRAF6 APAF1 TP53 BID RAD9A STK3 YAP1-1 MDM2-2 ATR SMC1A LATS1 EXO1 HSF1 RASSF1 TERF2 PCNA MDC1 RNF8 NABP2 CASP9 UPF1 TRIM28 CASP3 FANCD2 MCPH1 PARP1 MRE11 TP53BP1 BRCA2 RAD50 RAD51 E2F1 RAD17 NBN BAK1 DCLRE1C RIF1 CDK5 BAX RAD52 ABL1 ATM SMC3 TP73 CHEK2 TARGETED AGENTS IN TRIPLE NEGATIVE BREAST CANCER%WIKIPATHWAYS_20260510%WP5215%HOMO SAPIENS Targeted agents in triple negative breast cancer KRAS GRB2 PTEN RPTOR DEPTOR ARAF AKT2 AKT3 MLST8 PARP2 IRS1 MAPKAP1 RICTOR HRAS AKT1 TSC2 TSC1 PIK3CA MAPK1 PARP1 RAF1 AKT1S1 PIK3R1 EIF4EBP1 NRAS SOS1 SOS2 TELO2 INPP4B PDK1 MAP2K2;MAP2K1 RPS6KB1 MAPK3 PRR5L MTOR AR BRAF IDO METABOLIC PATHWAY%WIKIPATHWAYS_20260510%WP5414%HOMO SAPIENS IDO metabolic pathway KYNU IFNG KMO TNF TDO2 KYAT3 GOT2-1 AADAT KYAT1 IDO2 IDO1 REGULATION OF CYTOTOXIC T CELL RESPONSES BY MALAT1 MIR 15 16 CIRCUIT %WIKIPATHWAYS_20260510%WP5489%HOMO SAPIENS Regulation of cytotoxic T cell responses by Malat1 miR 15 16 circuit IL2 SPN CD27 CD3G CD247 CD3E CD86 CD3D BCL2 CD80 CD28 NRXN1 DELETION SYNDROME%WIKIPATHWAYS_20260510%WP5398%HOMO SAPIENS NRXN1 deletion syndrome GRIN2A NLGN1 GRIA1 GRIA2 GRIN2C GRIN3B NLGN3 GRIN2D GRIN3A NLGN2 NLGN4X;NLGN4Y GRIA3 GRIN2B GRIN1 DLG4 GRIA4 NRXN1;NRXN3;NRXN2 SOLUBLE ACE2 MEDIATED CELL ENTRY OF SARS COV 2%WIKIPATHWAYS_20260510%WP5076%HOMO SAPIENS Soluble ACE2 mediated cell entry of SARS CoV 2 ACE2 AGTR1 AVPR1B ADAM17 DNA MISMATCH REPAIR%WIKIPATHWAYS_20260510%WP531%HOMO SAPIENS DNA mismatch repair MSH6 PCNA POLD4 MSH2 POLD1 POLD3 POLD2 RPA1 RPA2 POLE4 EXO1 POLE RFC5 MLH1 RPA3 POLE2 PMS2 RFC3 RFC4 POLE3 RFC1 LIG1 RFC2 VITAMIN A AND CAROTENOID METABOLISM%WIKIPATHWAYS_20260510%WP716%HOMO SAPIENS Vitamin A and carotenoid metabolism RARG LPL CYP2E1 RXRB RXRA RXRG CRABP2 CRABP1 CYP26A1 RARB ALDH1A2 SDR16C5 RETSAT AWAT2 BCO2 CYP26B1 DHRS3 BCO1 RBP7 RBP4 CD36 RBP2 MAPK1 ABCG8 ABCG5 DGAT1 RARA RBP1 ALDH1A3 RDH8 RLBP1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 RPE65 NPC1L1 RDH12 RDH10 RDH5 LRAT SULT2B1 ADH4 ADH1C;ADH1B;ADH1A SCARB1 ALDH1A1 NEUROGENESIS REGULATION IN THE OLFACTORY EPITHELIUM%WIKIPATHWAYS_20260510%WP5265%HOMO SAPIENS Neurogenesis regulation in the olfactory epithelium SOX2 PLXND1 CXCL12 VLDLR RELN GHRL NUMB MYC TCF4 MEF2C NOTCH1 MAP2 JAG1 RTN4 KDM1A DAB1 PAX6 NEUROD1 PAFAH1B1 BDNF NTRK1 NGFR ID2-1 NTRK2 MAPT STAT3 MARK2 MECP2 GSK3B DLL1 AGRN NRG1 APP FAIM LRP8 SEMA4A RET NEURL1 NEUROG3 HES1 MRE11 MAP1B NGF ERBB4 PSEN1 ID1 NDEL1 NUMBL ASCL1 CDK5 DISC1 IL17A RTN4R NTRK3 CDK5R1 HEY1 APOPTOSIS MODULATION AND SIGNALING%WIKIPATHWAYS_20260510%WP1772%HOMO SAPIENS Apoptosis modulation and signaling CDKN2A BCL2 TNFRSF1B BIRC2 TRADD BCL2A1 PMAIP1 DAXX IKBKB NFKBIA BIRC5 JUN BIRC3 TRAF6 BIRC7 AIFM1 MCL1 APAF1 FASLG MADD MAP3K14 NFKB1 BBC3 CASP7 BAG3 CASP8 AIFM2 BCL2L11 RIPK1 FADD TP53 BID SMIM40 BCL2L1 CAPNS1 PIDD1 CASP1 PTPN13 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A HTRA2 SEPTIN4-1 TOLLIP TRAF3 PRKD1 MYD88 CASP6 BNIP3 CASP2 DFFB DFFA CASP10 ENDOG CASP9 HSPA1A;HSPA1B CASP3 MAP3K5 PEA15 BOK FOS PTRH2 TNFSF10 NAIP BCL2L10 BMF IL1R1 BLK XIAP CYCS-1 TNFRSF1A BAK1 BAD DIABLO-1 BAX MAPK8 FAS HRK IRAK1 MAPK3 IL1R2 TNFRSF25 CRADD CASP5;CASP4 BIK CFLAR BCL2L2 SUPPRESSION OF HMGB1 MEDIATED INFLAMMATION BY THBD%WIKIPATHWAYS_20260510%WP4479%HOMO SAPIENS Suppression of HMGB1 mediated inflammation by THBD AGER IKBKB NFKBIA THBD CHUK HMGB1-1 IKBKG RELA NFKB1 DEREGULATING CELLULAR METABOLISM THROUGH NON GENOTOXIC CARCINOGENS%WIKIPATHWAYS_20260510%WP5571%HOMO SAPIENS Deregulating cellular metabolism through non genotoxic carcinogens PHB2 HSPD1 OMA1 LARS1 LONP2 SESN2 EIF2A MARS1 LONP1 MYC TRAP1 IRS1 PHB AKT1 ATF4 TSC2 TSC1 FOXO1-1 SLC7A7 MTOR GDF15 CLPP RNA POLYMERASE II TRANSCRIPTION THE PREINITIATION COMPLEX%WIKIPATHWAYS_20260510%WP5563%HOMO SAPIENS RNA polymerase II transcription the preinitiation complex TAF10 TAF11 TAF7 TAF6 MED31-1 TAF4 TAF3 ERCC3 POLR2A POLR2B POLR2D POLR2G POLR2I NELFA POLR2J;POLR2J2;POLR2J3 NELFE MED9 NELFB MED15 CCNC-1 NELFCD MED1 TAF12 CDK8 MED23 TAF13 TAF8 MED27 ELK1 POLR2C TAF2 TAF1 CTDP1 TAF5 GTF2B MED19 MED16 MED14 MED18 MED17 MED12 MED11 MED13 MED10 MED8 GTF2F1 MED4 MED26 MED29 MED6 MED7 MED22 MED25 POLR2E MED24 POLR2F MED21 MED20 POLR2H TBP GTF2A1 POLR2L THRA MED28-1 TAF9 GTF2E2 MED30 POLR2M ENDOCHONDRAL OSSIFICATION WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260510%WP4808%HOMO SAPIENS Endochondral ossification with skeletal dysplasias PTH CHST11 IGF1R ALPL PTCH1 MEF2C ADAMTS1 VEGFA FRZB SERPINH1 HMGCS1-1 BMP7 TGFB2 BMP6 IGF2 IFT88 BMPR1A CDKN1C STAT5B STAT1 PLAU KIF3A MMP9 CTSV;CTSL FGFR3 FGF2 FGFR1 IGF1 ADAMTS4 ADAMTS5 TIMP3 GHR NKX3-2 PLAT SOX5 CAB39 SCIN SLC38A2 AKT1 MGP SOX6 RUNX3 COL10A1 SOX9 MMP13 COL2A1 DDR2 HDAC4 ACAN SPP1 CALM1 ENPP1 RUNX2 TGFB1 THRA GLI3 PRKACA-1 FGF18 IHH PTH1R PTHLH PEPTIDE GPCRS%WIKIPATHWAYS_20260510%WP24%HOMO SAPIENS Peptide GPCRs BDKRB2 BDKRB1 NTSR1 HCRTR2 HCRTR1 ATP8A1 NPY4R2;NPY4R TACR1 BRS3 CCKAR ACKR1 NPY5R TACR2 CCR10 TACR3 CCR1 OPRM1 MC1R AVPR1A SSTR3 SSTR4 TRHR CCR9 SSTR5 CCR8 OPRD1 CCR7 MC2R CCR6 GALR3 CCR4 GALR2 CCR2 GALR1 CXCR1 TAC4 NTSR2 MC5R CCKBR CXCR5 SSTR1 GHSR CXCR6 LHCGR CXCR2 C3AR1 EDNRA EDNRB CCR5 AGTR1 AGTR2 FPR2 C5AR1 FSHR NPY1R NMBR AVPR1B TSHR SSTR2 CX3CR1 MC3R GRPR AVPR2 FPR1 GNRHR MC4R OPRK1 CXCR4 OXTR OPRL1 NPY2R CXCR3 CCR3 NANOPARTICLE MEDIATED ACTIVATION OF RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP2643%HOMO SAPIENS Nanoparticle mediated activation of receptor signaling KRAS GRB2 PIK3CD ITGA1 AREG AKT3 HRAS MAPK1 RAF1 MAPK12 PXN MAPK11 NRAS SOS1 MAPK10 ITGB1 SRC FN1 TLN1 EGFR MAPK9 COL1A1 MAPK8 MAP2K2;MAP2K1 MAPK13 MAPK14 PTK2 CAFFEINE IN NEURONS%WIKIPATHWAYS_20260510%WP5602%HOMO SAPIENS Caffeine in neurons ADORA2A ADRA1D ADRA1B ADRA1A MINERALOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260510%WP5279%HOMO SAPIENS Mineralocorticoid biosynthesis UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP21A2 SRD5A2 SRD5A1 CYP11B1;CYP11B2 HSD11B1 HSD11B2 AKR1D1 ZINC HOMEOSTASIS%WIKIPATHWAYS_20260510%WP3529%HOMO SAPIENS Zinc homeostasis SLC39A12 SLC39A14 SLC39A9 SLC39A6 SLC39A5 MT2A SLC39A8 SLC39A7 SLC30A10 SLC30A7 SLC30A6 SLC30A8 SLC39A2 SLC30A3 SLC39A1 SLC30A2 SLC39A4 SLC30A5 MT3 SLC39A3 SLC30A4 SLC30A1 SLC30A9-1 MTF1 SLC39A11 SLC39A10 SLC39A13 UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260510%WP4925%HOMO SAPIENS Unfolded protein response ERN1 MBTPS1 BCL2L11 XBP1 BID TP53 PPP1R15A RTCB IL1B BCL2 CASP2 DDIT3 EIF2S1 TXNIP MBTPS2 PMAIP1 ATF4 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A EIF2AK3 NFE2L2 HSPA5 ATF6 BBC3 PRO SURVIVAL SIGNALING OF NEUROPROTECTIN D1%WIKIPATHWAYS_20260510%WP5182%HOMO SAPIENS Pro survival signaling of neuroprotectin D1 CASP7 CASP8 RIPK1 FADD CYCS-1 TNFRSF1A RIPK3 TRADD BAX CASP9 PPP2CB;PPP2CA CASP3 TNF BIRC3 TRAF2 NCRNAS IN WNT SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260510%WP4336%HOMO SAPIENS ncRNAs in Wnt signaling in hepatocellular carcinoma FOSL1 FRAT2 CTBP1 CCND1 NLK TCF7 CTNNB1 MYC DVL1 DVL2 DVL3 TCF7L2 RYK-1 AXIN1 EZH2 ROR1 TPTEP2-CSNK1E;CSNK1E ROR2 JUN ELAVL1 TCF7L1 MTDH KLF4 SERPINF1 LEF1 LRP5 LRP6 WNT1 SOX17 PLAU DKK4 CER1 CTNNBIP1 CSNK1A1 SOX7 CSNK2A2 DKK2 SFRP2 FZD6 SFRP5 CSNK2B PORCN APC CHD8 SOST KREMEN1 SENP2 CXXC4 NKD1 NKD2 WIF1 NOTUM GSK3B WNT2B FZD10 WNT5B WNT16 SFRP4 WNT6 WNT11 WNT2 WNT3 WNT10B WNT10A FZD3 FZD2 FZD5 CTBP2 WNT3A WNT7B FZD7 FZD9 WNT7A FZD8 FZD1 CCND3 WNT5A CSNK2A1;CSNK2A3 DKK1 SFRP1 CCND2 WNT4 BONE MORPHOGENIC PROTEIN SIGNALING AND REGULATION%WIKIPATHWAYS_20260510%WP1425%HOMO SAPIENS Bone morphogenic protein signaling and regulation SMAD6 SMAD4 SMAD1 SMURF1 RUNX2 TOB2 NOG BMPR1B TOB1 BMPR1A BMP2 BMPR2 ALA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260510%WP5136%HOMO SAPIENS ALA oxylipin metabolism ALOX15 ALOX5 EPHX2 SODIUM CHANNEL IN EPILEPSY%WIKIPATHWAYS_20260510%WP5598%HOMO SAPIENS Sodium channel in epilepsy PRRT2 SCN2B SCN1B SCN8A FYN SCN2A SCN4B GSK3B SCN9A WEE1 CAMK2A SCN3B JAK2 SCN10A NEDD4L AKT1 NEDD4 SCN5A BACE1 PSEN1 RACK1 PTPRN SCNM1;TNFAIP8L2-SCNM1 SCN11A PDCD10 SCN7A MAPK8IP2 CALM1 NFASC SCN4A RNF121 TNF FGF14 FGF13 SCN3A FGF12 SCN1A AFFECTED PATHWAYS IN DUCHENNE MUSCULAR DYSTROPHY%WIKIPATHWAYS_20260510%WP5356%HOMO SAPIENS Affected pathways in Duchenne muscular dystrophy PRG3 SIGMAR1 CASQ1 MPO TGFBR2 CAMK2D SERPINE1 MCU PRKAA1 TRPC6 CAPN3 PPIF DTNA NFKBIA DAG1 SSPN SNTB1 NOS2 NFKB1 SMAD2;SMAD3 SMAD4 CACNA2D1 SLC25A5 NOX4 TNNI1 FKBP1A MCUB AGTR1 SCX TOMM20 PLAU TRDN TNF SARAF PLA2G4A GP2 MMP2 TRPC3 CACNB1 FGB MMP9 FGA IL6 FGG ORAI1 SGCA TRPC1 ITPR1 IL1B ITPR2 STIM1 CYBB ITPR3 CASP9 TGFBR1-1 CACNB2 DMD VDAC1 CACNA1F CACNA1S CACNG1 CCN2 ELANE IL1A PRKAA2 ATP2A1 SPP1 RYR1 PLA2G2A-1 IL10 TGFB1 HSPA9 GLI1 IL3 SIGNALING%WIKIPATHWAYS_20260510%WP286%HOMO SAPIENS IL3 signaling IL3 PIK3CD FYN CD69 BCL2 VAV1 RAPGEF1 PTPN6 JAK2 HRAS HCK JUN MAPK1 RAF1 SOS1 BCL2L1 IL3RA IL5RA CSF2RB SRC JAK1 STAT5A LYN STAT5B SYK GAB2 STAT3 INPP5D GRB2 SHC1-1 CRKL CXCL8 AKT1 FOS CBL PIK3R2 PIK3R1 BAD PTPN11 MAPK8 YWHAB MAP2K2;MAP2K1 ENPP3 MAPK3 TGFB1 CD86 CCR3 PRKACA-1 YWHAQ FACT COMPLEX AND DNA DOUBLE STRAND BREAK REPAIR%WIKIPATHWAYS_20260510%WP5564%HOMO SAPIENS FACT complex and DNA double strand break repair MDC1 XRCC5 H4C1 NASP-1 XRCC6 RNF168-1 RAD51 RAD54L H4C6 SUPT16H RNF8 NAP1L1 SSRP1 NBN H4-16 SETD2 PRKDC ATM TP53BP1 NON GENOMIC ACTIONS OF 1 25 DIHYDROXYVITAMIN D3%WIKIPATHWAYS_20260510%WP4341%HOMO SAPIENS Non genomic actions of 1 25 dihydroxyvitamin D3 PLCB3 RXRB CYP27B1 RXRG CYP24A1 CAMK2B SP1 CAMK2D CAMK2A PLCB1 HRAS IKBKB ETS1 JUN IFNAR2 NFKB2 MAPK1 CAV1 NFKB1 MAPK12 MAPK11 IFNGR2 CD40LG CAMK2G NOD2 TLR2 STAT2 JAK1 STAT1 PLCB2 TNF PRKCG PRKCH IFI27L2 PRKCB RSAD2 PRKCE PRKCD PRKCA KRAS MED1 IL6 CAMP RXRA PRKCQ ISG15 IFI44L CXCL8 PRKCZ SP3 IFNGR1 TYK2 IFNG PLCE1 NRAS VDR TLR4 TNFRSF1A PLCB4 RELB CD40 CCL13;CCL2 PLCD1 MAPK9 MAPK8 TLR8 MAPK13 PLCG2 MAPK7 MAPK3 MAPK14 DEFB4A;DEFB4B CLOCK CONTROLLED AUTOPHAGY IN BONE METABOLISM%WIKIPATHWAYS_20260510%WP5205%HOMO SAPIENS Clock controlled autophagy in bone metabolism IL3 PTH PLEKHM1 NR1D2 BCL2 NOTCH1 CTSK PIK3C3 TRAP1 JAK2 ATG7 CTHRC1 BHLHE40 TRAF6 TNFRSF11B TNFRSF11A BMP5 TNFSF11 VCP-1 LEP SMAD4 BMP6 SERPINF1 ATG13 BMPR2 LRP5 ULK1 SP7 BMP3 MAP1LC3B2;MAP1LC3B-1 ARHGAP4 ATG101 FYCO1 ATG4C MTOR CHRD DRAM2 SEMA4D CALCA SOST IL6 IGF1 MAP1LC3A SQSTM1 RB1CC1 ATG5 ATG3 ATG10 AKT1 MEPE CTF1 CSF1 WNT16 ATG12-1 BECN1 ATG16L1 BHLHE41 LAMP2 RORB CRY1 WNT10B CLOCK PRKAA2 ARNTL HMGB1-1 SEMA3A AMBRA1 NFATC1 WNT5A PER1 NPAS2 RUNX2 SMAD1 BMP4 TGFB1 SMAD9 DKK1 SMAD5 EFNB2 BMP2 7 OXO C AND 7 BETA HC PATHWAYS%WIKIPATHWAYS_20260510%WP5064%HOMO SAPIENS 7 oxo C and 7 beta HC pathways CYP7A1 ACOT6 ACOT4 SCP2 ACOT2;ACOT1 NPC1-1 SLC27A2 NPC2 EBP HSD11B1 HSD11B2 DHCR7 BAAT DBP THEM5 CYP27A1 ACOT9 AMACR ACOT8 EPHX2 ACOX2 ACOT7 ACOT11 SLC27A5 ACOT12 ACOT13 EXERCISE AND HYPERTROPHY IN SKELETAL MUSCLE%WIKIPATHWAYS_20260510%WP516%HOMO SAPIENS Exercise and hypertrophy in skeletal muscle ADAM10 EIF4EBP1 IFNG IL1R1 CCN1 IL1A NR4A3 ATF3 IFRD1 MSTN EIF4E VEGFA JUND ZEB1 DUSP14 HBEGF IL18 ANKRD1 MYOG WDR1 NPHP1 DELETION SYNDROME%WIKIPATHWAYS_20260510%WP5399%HOMO SAPIENS NPHP1 deletion syndrome INVS PTK2B FLNB NPHP1 FLNC BCAR1 MAPK3 RPGRIP1L MAPK1 FLNA N GLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260510%WP5153%HOMO SAPIENS N glycan biosynthesis B4GALT3 PMM2 MPDU1 GPI RFT1 DPM2 DPAGT1 MGAT4A-1 ALG1 MPI GMPPB MAN1A2 GMPPA TUSC3 MAN1A1 ALG8 ST6GAL1 ALG9 ST6GAL2 ALG5 ALG2 ALG14 ALG3 MOGS ALG12 FUT8 ALG11 DDOST DPM3 DAD1 MAN1B1 GANAB MAN2A2 MAN2A1 MGAT5 MAN1C1 MGAT3 MGAT2 MGAT5B-1 SRD5A3 DOLK MGAT4C MGAT4D DOLPP1 MGAT4B DPM1 STT3A STT3B ALG10;ALG10B ALG6 RPN2 RPN1 MGAT1 B4GALT2 B4GALT1 PROTEOGLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260510%WP4784%HOMO SAPIENS Proteoglycan biosynthesis SLC35B3 SLC35B2 B3GALT6 PAPSS2 CHST14 CANT1 BPNT2-1 CHST3 XYLT2 XYLT1 B4GALT7 EXTL3 CSGALNACT1 B3GAT3 EXT1 EXT2 SLC26A2 CHSY1-1 PRADER WILLI AND ANGELMAN SYNDROME%WIKIPATHWAYS_20260510%WP3998%HOMO SAPIENS Prader Willi and Angelman syndrome NUP155 NUP153 OXT-1 POMC NUP35 MKRN3 NUP37 GHRH GHRL CCND1 CDKN2A UBE3A MDM4 NUP88 TACR3 CDK6 CDK4 EIF4E KISS1 INS;INS-IGF2 NUP62 AHCTF1 NUP98 GABRG1 RAE1 TP53 CDC6 SNURF MDM2-2 BDNF DLX5 GABRB3 NDN GABRG3;GABRG2 NUP85 POM121;POM121C CYFIP1 GABRR3 TUBGCP2 GABRR2 TUBGCP5 GABRR1 NIPA1 GABRD SNRPN TUBGCP6 TUBGCP3 TUBGCP4 NIPA2 RNF8 GABRA5 CDKN2B CDKN2C PCSK1 HERC2 PRKCZ NUP43 UBE2N CGA BBS4 NUP133 NGF LHB ATP10A E2F1 NUP107 NUP188 FMR1 GLE1 FSHB MAGEL2 NDC1 GNRH1 NUP214 SEC13 NUP210 NUP93 NUP50 FEZ1 TYR FEZ2 NUP54 RB1 OCA2 NUP205 SLC45A2 MSX1 SEH1L NUP58-2 AAAS NUP160 TPR CCND2 NHLH2 NUP42 RANBP2 VITAMINS A AND D ACTION MECHANISMS%WIKIPATHWAYS_20260510%WP4342%HOMO SAPIENS Vitamins A and D action mechanisms RARA RXRA VDR INHIBITORS OF METABOLISM IN MELANOMA THERAPY%WIKIPATHWAYS_20260510%WP5609%HOMO SAPIENS Inhibitors of metabolism in melanoma therapy GPX4 LDHA PKM RPTOR G6PD ARAF MLST8 PFKFB2 TRAP1 NAMPT SLC16A1 PDHA1 MITF MAPK1 GSR RAF1 DLAT PPARGC1A ACSS1 PKLR RPS6KA2 MAP2K2;MAP2K1 SLC1A5 PGLS GLS RPS6KA3 RPS6KA1 MAPK3 LDHB SLC16A3 CPT1A MTOR BRAF SLC2A1 DLD HIJACK OF UBIQUITINATION BY SARS COV 2%WIKIPATHWAYS_20260510%WP4860%HOMO SAPIENS Hijack of ubiquitination by SARS CoV 2 ELOB UBA3 RBX1 NAE1 ZYG11B CBFB CUL2 ELOC-1 STEROL REGULATORY ELEMENT BINDING PROTEINS SREBP SIGNALING%WIKIPATHWAYS_20260510%WP1982%HOMO SAPIENS Sterol regulatory element binding proteins SREBP signaling LPL KPNB1 LDLR SAR1A INSIG2 RNF139 SP1 SCAP SEC23B SEC31B SEC31A PRKAA1 SEC24B AMFR SEC24D-1 LPIN1 SCD SEC24C FASN MDH1 NFYA-1 INS;INS-IGF2 PIK3CA PPARGC1B ACLY PPARG ATF6 HMGCS1-1 PRKAB2 PRKAB1 MBTPS1 GSK3A IDI1 FDPS MED15 MBTPS2 PRKAG1 PRKAG2 PRKAG3 MVD FDFT1 SREBF2 MTOR HMGCR CAMP SEC24A CDK8 NR1H2 CYP51A1 SIRT1 SREBF1 AKT1 GPAM RBP4 LSS CREB1 SAR1B PRKAA2 ACACA ACSS1 FGF21 SEC13 SQLE INSIG1 PRKACA-1 SCARB1 YY1 SEC23A GLUCOCORTICOID RECEPTOR PATHWAY%WIKIPATHWAYS_20260510%WP2880%HOMO SAPIENS Glucocorticoid receptor pathway NR1I2 TNFAIP3 SEC14L1 PTGS2-2 LRRC8A PLK2 CPEB4 EPB41L4B ENC1 BIRC2 EDN2 TSC22D3 SERPINB9 CDC42EP3 PMP2 CUL1 POU5F1;POU5F1B FGD4 MGAM SPRY1 GPR153 SERTAD2 JUN CAVIN2 BHLHE40 NFKB2 BIRC3 KTN1 SCNN1A ANKRD1 SLC26A2 TNS4 ABHD2 DNAJC15 ARL5B SRGN FGFBP1 NAV3 ADGRF4 PRRG4 PPP1R14C CCL20 S100P RGS2 CDKN1C IL11 ZIC2 TGFBR3 RXRA THBD SLC19A2 AMIGO2 ACKR3-2 MFGE8 AKAP13 HSP90AA1 PTGES3-1 PDE4B STOM DNER GADD45B NR1I3 CCL13;CCL2 NR3C1 ETNK2 ALOX5AP B3GNT5 SNAI2 ANGPTL4 LEPTIN SIGNALING%WIKIPATHWAYS_20260510%WP2034%HOMO SAPIENS Leptin signaling PTPN1 KHDRBS1 PTEN FYN SP1 SOCS2 PRKAA1 IRS1 JAK2 HRAS KPNA4-1 IKBKB ROCK1 ROCK2 EIF4E ESR1 CHUK FOXO1-1 ACACB CDC42 ERBB2 MAPK1 PDE3B IKBKG RAF1 NFKB1 LEPR LEP SOS1 GSK3A SRC JAK1 STAT5B STAT1 RPS6 RPS6KB1 RPS6KA1 STAT3 MTOR REL GRB2 SHC1-1 GSK3B ELK1 RAC1 CFL2 AKT1 CISH SOCS7 RHOA PIK3R2 PIK3R1 EIF4EBP1 CREB1 NCOA1 PRKAA2 ACACA SOCS3 BAD RELA PTPN11 MAPK8 MAP2K2;MAP2K1 PLCG2 PLCG1 MAPK3 SH2B1 NOS3 MAPK14 PTK2 KETOGENESIS AND KETOLYSIS%WIKIPATHWAYS_20260510%WP4742%HOMO SAPIENS Ketogenesis and ketolysis ACAT1 BDH1 OXCT1-1 SLC16A1 CPT2 UCP2 SLC25A20 SLC2A1 16P11 2 PROXIMAL DELETION SYNDROME%WIKIPATHWAYS_20260510%WP4949%HOMO SAPIENS 16p11 2 proximal deletion syndrome PRRT2 PTEN PPP2R1A HIRA PPP2R5D QPRT MAZ DOC2A PPP4R1 PPP4R2 IGFBP3 TBX6 PPP4R4 ESR1 CCT3 CCT2 TRAF6 KIF22 TRAF2 TLCD3B ASPHD1 TCP1 PPARG KCTD13 NFKB1 TMEM219 MAP2K6 ZG16 INO80E CASP8 MVP GDPD3 UNC13A PAXIP1 SEZ6L2 TP53 CORO1A HIRIP3 MAP2K3 PPP4C TAOK2 CCT8 CCT5 CCT4 IGBP1 C16orf92 PARP4 C16orf54 KMT2D CCT6A SIAH1 YPEL3 PPP4R3A PPP4R3B KMT2C CCT6B REL PCNA ALDOA CDIPT BPTF SPN EZR UNC13B CCT7 PAGR1 MSN NR3C1 PPP2CB;PPP2CA MAPK3 HDAC3 CCDC6 TAMOXIFEN METABOLISM%WIKIPATHWAYS_20260510%WP691%HOMO SAPIENS Tamoxifen metabolism CYP1A1 CYP2C9;CYP2C19 CYP2E1 CYP1A2 SULT2A1-4 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 FMO1 FMO3 CYP2D6;LOC107987479;LOC107987478-1 CYP1B1 CYP2A13;CYP2A6;CYP2A7-1 ANGIOGENESIS OVERVIEW%WIKIPATHWAYS_20260510%WP1993%HOMO SAPIENS Angiogenesis overview PLXND1 PIK3CD ATF2 F2 KDR PTK2B SLIT2 TIMP4 ROBO1 PLA2G1B WAS VEGFA DAG1 CDC42 SHB MAPK1 RAF1 MAP2K6 MAPK11 SOS1 GRB14-1 NOX4 SRC MAP3K7 BMX PRKCA GRB7 MTOR MMP2 APC MMP9 KRAS GRB2 TEK SHC1-1 FGFR1 DOK2 NCK1 ELK1 MAP2K4 PDPK1 RAC1 AKT1 CRK SEMA4A PXN IQGAP1 PAK1 BAD NRP1 PTPN11 SEMA3A VHL FGF1 FRS2 MAPK8 MAP2K2;MAP2K1 PLCG1 TIMP2 ROBO4 MMP14 NOS3 ANGPT1 MAPK14 HIF1A AND PPARG IN HYPERTROPHIC CARDIOMYOPATHY%WIKIPATHWAYS_20260510%WP2456%HOMO SAPIENS HIF1A and PPARG in hypertrophic cardiomyopathy LDHA GAPDH-1 CD36 HIF1A TPI1 GPD1 SLC2A1 GPAT3 PPARG MESODERMAL COMMITMENT PATHWAY%WIKIPATHWAYS_20260510%WP2857%HOMO SAPIENS Mesodermal commitment pathway SOX2 RARG SESN1 HNF4A NLK CSRP2 SETD2 RARB TCF4 MEIS1 POU5F1;POU5F1B AXIN1 NFE2L2 FOXA1 NODAL TCF7L1 SMAD2;SMAD3 PBX1 TBX3 SMAD4 NANOG;NANOGP8 HAND1 YAP1-1 PLCH1 LATS1 HTT CHRD C1QBP ASCC3 PRKAR1A TET1 VAV3 AEBP2 SRF ELK4 FGF8 HPRT1 C9orf72 TBX1 ARID5B CTBP2 BCORL1 KDM6A PPP2CB;PPP2CA FOXA2 SMAD1 LEFTY2;LEFTY1 PBX3 DKK1 CCDC6 PRKACA-1 GATA6 CCND1 CUL4B KLF5 ZFHX4 JAK2 HES7 FOXC1 PIAS1 BHLHE40 TBX6 AXIN2 ACVR1 BMP7 ACVR2B PAX6 KLF4 TOX3 BMPR1A LEF1 BMPR2 IQCJ-SCHIP1;SCHIP1 RGS10 ADAM19 TWSG1 PITX2 MACF1 SOX17 CCDC88A SOX21 MSGN1 ACVR2A CEP250 ARL4A DIP2A JARID2 WDCP AMH WDHD1 RPL38 ZNF281 EMSY MIXL1 WDFY2 ZIC2 MBTD1 EPB41L5 UBR5 ATP8B2 GDF3 TRERF1 FGFR1 HMGA2 NABP2 TRIM71 NCAPG2 PHF6 DLL1 TRIM28 TRIM5 EOMES EXT1 ZIC3 EXT2 PARP8 NOG DDAH1 FOXH1 TOX AHDC1 ZNF462 SMAD6 ELP4 CRTC1 WNT3 GATA3 FZD5 DNMT3B ACACA FZD4 MTF2 WNT3A FZD8 TEAD1 FOXC2 INHBA TEAD2 GRHL2 BMP4 SNAI1 SLC2A12 REGULATION OF SISTER CHROMATID SEPARATION AT THE METAPHASE ANAPHASE TRANSITION%WIKIPATHWAYS_20260510%WP4240%HOMO SAPIENS Regulation of sister chromatid separation at the metaphase anaphase transition BUB3 MAD2L1 STAG1 BUB1B BUB1 MAD1L1 PTTG1;PTTG2 SMC1A SMC3 CENPE ESPL1 CDC20 RAD21 APC CHOLESTASIS%WIKIPATHWAYS_20260510%WP5238%HOMO SAPIENS Cholestasis TJP2 RXRA LDLR ATP8B1 EPHX1 ABCB4 NR1I3 SLCO1A2 ABCB11 ABCC3 ABCC4 ABCC2 SLC10A1 SLC22A1 NR1H4 HMGCR ABCG8 SCARB1 ABCG5 PHOSPHOINOSITIDE 3 KINASE PI3K FAMILY%WIKIPATHWAYS_20260510%WP5472%HOMO SAPIENS Phosphoinositide 3 kinase PI3K family PIK3R1 PIK3CD PIK3CB PIK3CG PIK3R4 PIK3C2G PIK3C2A PIK3R6 PIK3C2B PIK3R5 PIK3CA PIK3R3 PIK3R2 KILLER CELL IMMUNOGLOBULIN LIKE RECEPTORS AND HUMAN LEUKOCYTE ANTIGEN C PATHWAY%WIKIPATHWAYS_20260510%WP5576%HOMO SAPIENS Killer cell immunoglobulin like receptors and human leukocyte antigen C pathway IFNG GRB2 PRKCQ FYN HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CD34 ITPR1 VAV1 PTPN6 TYROBP SYK RAC1 HRAS TNF PLCG1 CSF2 LAT PRKCA LCP2 PTPN2 CCL18 SIGNALING%WIKIPATHWAYS_20260510%WP5097%HOMO SAPIENS CCL18 signaling PTK2B CDH2 CCR8 ZEB2 AK4-1 MMP2 PCSK9 MEDIATED LDL RECEPTOR DEGRADATION%WIKIPATHWAYS_20260510%WP2846%HOMO SAPIENS PCSK9 mediated LDL receptor degradation PCSK9 LDLR MITOCHONDRIAL CARRIER DEFICIENCY ASSOCIATED WITH SHUTTLE DISTURBANCES%WIKIPATHWAYS_20260510%WP5507%HOMO SAPIENS Mitochondrial carrier deficiency associated with shuttle disturbances GLUD1;GLUD2 SLC25A22 SLC25A12 SLC25A13 GOT2-1 10Q11 21Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP5352%HOMO SAPIENS 10q11 21q11 23 copy number variation syndrome ERCC5;BIVM-ERCC5 SMARCC2 ATF2 BCL2 ERCC8 CHAT DLST NEO1 SF3B1 ELOA SLC18A3 BMPR1B BMPR1A GDF5 HSF1 NLRP3 FRMPD2 OGDHL FAM170B VSTM4 SIRT6 C10orf71 BAZ1B RGMB DLD WDFY4 PCNA PARG LRRC18 ARHGAP22 HSF4 DRGX MYO1C KDM4D C10orf53 SMARCA5 DEK TMEM273 UVSSA SIRT1 ELK1 CDH1 NOG MEN1 ERCC6 CLOCK ARNTL RIF1 EIF4ENIF1 ITCH MAPK8 SMAD1 DDX21 SMAD9 SMARCB1 JUND SMAD5 MYBBP1A CUL5 BMP2 TRANS SULFURATION ONE CARBON METABOLISM AND RELATED PATHWAYS%WIKIPATHWAYS_20260510%WP2525%HOMO SAPIENS Trans sulfuration one carbon metabolism and related pathways GPX4 DNMT3L SARDH GSS GSR MTR-1 GCLC GCLM GPX5 GAD1 GAD2 PCYT1A CHKA AGXT2 CHPT1 ALDH7A1 CDO1 BAAT SHMT1 AMT BCAT1 CBS;CBSL BCAT2 GPX1 PEMT GPX6 DMGDH AHCYL1 SHMT2 SLC25A48 PSAT1 PHGDH BHMT2 MAT2A PSPH GPX7 CTH MTHFD2L GNMT DNM1 DHFR2;DHFR AHCYL2 SOD3 MAT2B TYMS MTHFD1L DNMT3B DNMT3A MTHFR MAT1A BHMT PCYT1B MTHFD1 MTHFD2 CHKB CSAD PCYT2 CHDH AHCY ETNK2 SOD1 ETNK1 CEPT1 PLD1 DEGRADATION PATHWAY OF SPHINGOLIPIDS INCLUDING DISEASES%WIKIPATHWAYS_20260510%WP4153%HOMO SAPIENS Degradation pathway of sphingolipids including diseases HEXA GALC NEU3 NPC2 NEU4 SCARB2 GLB1 ARSA GLA LIPA GM2A PSAP NPC1-1 NEU1 NEU2 HEXB GBA ESTROGEN METABOLISM%WIKIPATHWAYS_20260510%WP697%HOMO SAPIENS Estrogen metabolism CYP1A1 CYP1A2 NQO1 UGT1A1;UGT1A6 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 STS UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 COMT ARSD-1 ARSL CYP1B1 GSTM1;GSTM2-1 GSTA3;GSTA1 NUCLEOTIDE EXCISION REPAIR IN XERODERMA PIGMENTOSUM %WIKIPATHWAYS_20260510%WP5114%HOMO SAPIENS Nucleotide excision repair in xeroderma pigmentosum RAD23A GTF2H1 H3-3A GTF2H3 GTF2H4 HMGN1 RAD23B CUL4A RBX1 DDB1 ERCC3 ERCC4 USP7 ERCC1 ERCC2 ERCC8 MNAT1 CUL4B BRCA1 CHD1L POLH POLE4 POLE3 RAD18 CDK7 XRCC1 PCNA XAB2 H4C1 H4C6 LIG3 H4-16 UVSSA SLX4 POLK POLE RFC5 SLX4IP RFC3 DDB2 RFC4 PARP1 ERCC6 POLD4 GPS1 POLD1 POLD3 POLD2 RPA1 RPA2 CCNH RPA3 POLE2 GTF2H2C;GTF2H2C_2;GTF2H2 CETN2 XPA XPC RFC1 LIG1 RFC2 PATHOGENESIS OF SARS COV 2 MEDIATED BY NSP9 NSP10 COMPLEX%WIKIPATHWAYS_20260510%WP4884%HOMO SAPIENS Pathogenesis of SARS CoV 2 mediated by nsp9 nsp10 complex PRG3 IL6 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 NKRF LCK FYN CD8A MMP25 CD8B;CD8B2 CXCL8 CRP CD3G CD4 IGLL5;IGLL1 HLA-DRA CD247 CD3E LBP CD2 ZAP70 ALTERNATIVE PATHWAY OF FETAL ANDROGEN SYNTHESIS%WIKIPATHWAYS_20260510%WP4524%HOMO SAPIENS Alternative pathway of fetal androgen synthesis POR CYP11A1 SRD5A2 HSD3B1;HSD3B2 STAR HSD17B6 CYP17A1 CYB5A HSD17B3 SEROTONIN TRANSPORTER ACTIVITY%WIKIPATHWAYS_20260510%WP1455%HOMO SAPIENS Serotonin transporter activity MAOA PPP2CB;PPP2CA NOS1 STX1A TPH2 IL1R1 SLC6A4 TGFB1I1 IL1B SCAMP2 ITGB3 VITAMIN A1 AND A5 X PATHWAYS%WIKIPATHWAYS_20260510%WP5397%HOMO SAPIENS Vitamin A1 and A5 X pathways RARG RARA RXRB RXRA RXRG RARB FOLATE ALCOHOL AND CANCER PATHWAY HYPOTHESES%WIKIPATHWAYS_20260510%WP1589%HOMO SAPIENS Folate alcohol and cancer pathway hypotheses ALDH1L1 CREB1 CYP2E1 ADH5 CEBPB MTHFR CBS;CBSL ALDH1A1 MTR-1 COVID 19 AND ENDOTHELIAL CELL SENESCENCE%WIKIPATHWAYS_20260510%WP5256%HOMO SAPIENS COVID 19 and endothelial cell senescence IL17RC TLR4 IL17A IL17RA ANO6 SARS COV 2 REPLICATION ORGANELLE FORMATION%WIKIPATHWAYS_20260510%WP5156%HOMO SAPIENS SARS CoV 2 replication organelle formation PIK3R4 ACTIVATION OF NLRP3 INFLAMMASOME BY SARS COV 2%WIKIPATHWAYS_20260510%WP4876%HOMO SAPIENS Activation of NLRP3 inflammasome by SARS CoV 2 CASP1 TRAF3 PYCARD NLRP3 IL1B RELA NFKB1 ROLES OF CERAMIDES IN DEVELOPMENT OF INSULIN RESISTANCE%WIKIPATHWAYS_20260510%WP5181%HOMO SAPIENS Roles of ceramides in development of insulin resistance PIK3R1 TRAF1 ERN1 TNFRSF1A SLC2A4 ACSL1 IRS2 IRS1 PRKCZ MAPK8 PPP2CB;PPP2CA CPT1B RPS6KB1 MAFA PRKAG3 TNF AKT1 INSR INS;INS-IGF2 CD36 PDX1 EIF2AK2 SMPD3 AUTOPHAGY%WIKIPATHWAYS_20260510%WP4923%HOMO SAPIENS Autophagy RPTOR DEPTOR PRKAA1 RB1CC1 MLST8 ATG5 ATG3 PIK3C3 PIK3R4 ATG7 WIPI2 ATG14 BECN1 ATG12-1 ATG16L1 AKT1S1 PRKAB2 PRKAB1 PRKAA2 UVRAG ATG13 ULK1 AMBRA1 PRKAG1 PRKAG2 PRKAG3 ATG9A MAP1LC3B2;MAP1LC3B-1 ATG101 MTOR ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20260510%WP528%HOMO SAPIENS Acetylcholine synthesis ACHE CHAT PEMT PDHA1 PCYT1A CHKA SULFATASE AND AROMATASE PATHWAY%WIKIPATHWAYS_20260510%WP5368%HOMO SAPIENS Sulfatase and aromatase pathway CYP19A1 HSD3B1;HSD3B2 ESR1 SLCO2B1 SLCO4A1 SLCO1A2 SLCO4C1 HSD17B3 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 HSD17B1 HSD17B2 ESR2 RANKL RANK SIGNALING%WIKIPATHWAYS_20260510%WP2018%HOMO SAPIENS RANKL RANK signaling TRAF1 TAB1 FHL2 AKT2 IKBKB NFKBIA JUN NFKB2 CHUK TRAF6 TNFRSF11B CDC42 MAPK1 IKBKG TRAF2 TNFRSF11A TRAF5 NFKB1 TNFSF11 MAP2K6 PAPSS2 SRC LYN MAP3K7 SYK STAT1 GAB2 TAB2 MTOR TRAF3 SQSTM1 RAC1 AKT1 MITF FOS CBL PIK3R2 PIK3R1 MAP2K7 RELB RELA MAPK9 NFATC1 MAPK8 MAP2K2;MAP2K1 SPI1 PLCG1 MAPK3 MAPK14 PTK2 8Q11 23 RB1CC1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5412%HOMO SAPIENS 8q11 23 RB1CC1 copy number variation GABARAP TP53 ATG13 ULK1 RB1CC1 PTK2B TNF RB1 MAP3K5 GABARAPL2 ATG101 TRAF2 ATG16L1 WDR45B PTK2 VITAMIN D METABOLISM%WIKIPATHWAYS_20260510%WP1531%HOMO SAPIENS Vitamin D metabolism PTH RXRB RXRA VDR CYP27B1 CYP24A1 CYP2R1 CYP27A1 DHCR7 GC DICLOFENAC METABOLIC PATHWAY%WIKIPATHWAYS_20260510%WP2491%HOMO SAPIENS Diclofenac metabolic pathway CYP2C9;CYP2C19 CYP2B6 CYP2C18-1 LET 7 INHIBITION OF ES CELL REPROGRAMMING%WIKIPATHWAYS_20260510%WP3299%HOMO SAPIENS let 7 inhibition of ES cell reprogramming SOX2 POU5F1;POU5F1B KLF4 EGR1 MYC TRIM71 SARS COV 2 ALTERING ANGIOGENESIS VIA NRP1%WIKIPATHWAYS_20260510%WP5065%HOMO SAPIENS SARS CoV 2 altering angiogenesis via NRP1 ACE2 KDR VEGFA NRP1 FURIN HYPOTHESIZED PATHWAYS IN PATHOGENESIS OF CARDIOVASCULAR DISEASE%WIKIPATHWAYS_20260510%WP3668%HOMO SAPIENS Hypothesized pathways in pathogenesis of cardiovascular disease FBN2 FBN3 TGFBR3 SMAD4 LTBP2 CCN2 TGFBR2 SHC1-1 SERPINE1 FLNA POSTN MAPK8 AGTR1 TGFBR1-1 RUNX2 MAPK3 ANGPT2 MAPK1 ENG MAPK14 LTBP1 NR2C2 SMAD2;SMAD3 FBN1 PTF1A RELATED REGULATORY PATHWAY%WIKIPATHWAYS_20260510%WP4147%HOMO SAPIENS PTF1A related regulatory pathway PROX1 FGF10 RBPJL PTF1A RBPJ KAT2B NKX6-1 CTNNB1 PDX1 HES1 NOTCH1 MALE INFERTILITY%WIKIPATHWAYS_20260510%WP4673%HOMO SAPIENS Male infertility CYP1A1 TEX15 EP300 USP26;USP29 PON2 PON1 CXXC1 ABLIM1 OR2W3 LRWD1 CDC42BPA MLH3 BCL2 CTCFL BRDT DDX20 CREBBP ESR1 NFE2L2 MTRR NOS2 MTR-1 TCN2 USP8 ABCB1 UBD CDK9 RGS9 CCNA1 SHMT1 DND1 XRCC3 THBS1 MMP2 MMP9 GPX1 H4C1 NOS1 PEMT PEX10 POLB PSAT1 SOX5 CAT SEPTIN12 ETV5 GNAO1 BRCA2 XRCC5 NQO1 AHRR APOB UBE2B CHD2 LIG4 AR XPC MSH4 RFC1 MSH5 SLC16A7 KLK3;KLK2 ERCC1 STRA8 ERCC2 TRIP13 LTF CYP26B1 CCNT1 XRCC4 PMS2 XRCC2 FASLG DAZL CLU MDM2-2 TNF HLA-DRA INSR POLG SLC46A1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CYP17A1 AGO2 SRD5A2 AHR MLH1 TMEM132E PARP1 SOD3 REC8 CCNK IHO1 CLOCK UBR2-2 RAG1 NANOS1 SIRPA;SIRPB1;SIRPG ARNTL PRDM7;PRDM9 PRM3 MTHFR SPATA17 TSSK6 BHMT TSSK4 FOLH1B;FOLH1 MTHFD1 DDX4 MOV10L1 PUM2 CCNT2-1 PIWIL2 CRISP2 FAS EPPIN;EPPIN-WFDC6 ATM PIWIL1 PIWIL4 PIWIL3 SPO11 YBX2 KDM3A HORMAD2 NOS3 HORMAD1 MSMB PRMT6 ESR2 PACRG NOTCH SIGNALING%WIKIPATHWAYS_20260510%WP268%HOMO SAPIENS Notch signaling HDAC2 HDAC1 MAML1 CTBP1 NUMB DTX2 DVL1 PTCRA NOTCH2 RFNG DVL2 DTX3 DVL3 NOTCH1 MFNG JAG2 DLL1 CREBBP DLL3 LFNG DLL4 JAG1 KAT2B HES1 NCOR2 INPP5K RBPJL PSEN2 KCNJ5 PSEN1 ADAM17 RBPJ NUMBL CTBP2 DTX1 APH1B DTX4 HES5 MAML3 APH1A NCSTN NOTCH3 DTX3L KAT2A NOTCH4 REGULATION OF TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP1449%HOMO SAPIENS Regulation of toll like receptor signaling CXCL10 IRAK2 CXCL11 IRAK3 TAB1 CCL3L1;CCL3L3;CCL3;CCL18 CXCL9 PTPN6 FBXW5 CD180 TRAFD1 SIGIRR CUEDC2 IKBKB NFKBIA SFTPD JUN RNF31 IFNAR2 NFKB2 PELI3 CHUK PIK3CA CTNNAL1 MAP3K8 TRAF6 SARM1 MAPK1 IKBKG NFKB1 MAP2K6 IFNAR1 RNF216 RIPK1 PLK1 IFNB1-4 MAP2K3 RNF41 TOLLIP TBK1 TMED7 IKBKE TICAM1 MYD88 TREM1 IRF3 IRF7 TLR7 TLR3 CISH TIRAP RBCK1 IL12B IL12A TICAM2 CD14 IRF5 MAPK13 SOCS1 CD86 LBP OTUD5 TIFA PIK3CD TNFAIP3 PIK3CB PIK3CG CYLD USP7 AKT2 AKT3 MLST8 IRAK4 PIK3R5 MAPK12 MAPK11 CASP8 FADD TLR2 MAP3K7 ZMYND11 SYK STAT1 TNF BTK TAB2 IL6 TRAF3 IL1B CD80 PELI1 SQSTM1 CXCL8 PELI2 MAP2K4 LY96 TAB3 RAC1 AKT1 MBL2-1 PIK3R3 FOS PIK3R2 PIK3R1 SMAD6 TLR9 TLR6 MAP2K7 TLR5 TLR4 MAPK10 RELA CD40 SPP1 MAPK9 MAPK8 TLR8 MAP2K2;MAP2K1 CCL4L2;CCL4L1;CCL4 TLR1 CCL5 IRAK1 MAPK3 MAPK14 7Q11 23 DISTAL COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5401%HOMO SAPIENS 7q11 23 distal copy number variation KIF1C POR ZP1 ZP2 HSPB1 RHBDD2 ZP3;POMZP3 MDH2 G3BP1 LMNA SRRM3 SFN TMEM120B TMEM120A RAF1 DAPK2 SSC4D STYXL1 PTPMT1 YWHAG MODULATORS OF TCR SIGNALING AND T CELL ACTIVATION%WIKIPATHWAYS_20260510%WP5072%HOMO SAPIENS Modulators of TCR signaling and T cell activation ITK TNFAIP3 CD8A MAP4K1 VAV1 CD28 PTPN6 ELOB IKBKB RASA2 NFKBIA GRAP2 CHUK GNA13 MAP3K8 TRAF6 ZAP70 IKBKG LCP2 CARD11 BCL10 MAP3K14 MALT1 NFKB1 MEF2D DGKA TMEM222 ARIH2 UBASH3A ZFP36L1 SH2D1A RPRD1B DGKZ FIBP CD5 REL GRB2 PRKCQ AGO3;AGO1 CBLB NDUFB10 PDPK1 CD3G AKT1 CD3E CD3D PCBP2 PIK3R2 PIK3R1 LCK SH2B3 RELA RHOH CDKN1B SOCS1 PLCG1 RNF7 CD247 LAT SMARCB1 CUL5 MELATONIN METABOLISM AND EFFECTS%WIKIPATHWAYS_20260510%WP3298%HOMO SAPIENS Melatonin metabolism and effects CYP1A1 CYP2C9;CYP2C19 CYP1A2 MTNR1B GSK3B ADRB1 CAMK2A ECE1 SIRT1 CSNK1D MAP2 EDN1 TPTEP2-CSNK1E;CSNK1E FOXO1-1 TRAF6 CYP1B1 CRY2 NFKB1 ACHE CRY1 CLOCK ARNTL APOE SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 ASMT AANAT CALM1 MAOA MTNR1A PER1 IRAK1 PRKCA CYP2D6;LOC107987479;LOC107987478-1 PER2 TOLL LIKE RECEPTOR SIGNALING RELATED TO MYD88%WIKIPATHWAYS_20260510%WP3858%HOMO SAPIENS Toll like receptor signaling related to MyD88 REL TOLLIP TBK1 IKBKE TRAF3 TICAM1 MYD88 IRF3 IRF7 TLR7 TLR3 IRAK4 IKBKB TIRAP NFKB2 CHUK TRAF6 MAPK1 IKBKG NFKB1 TLR9 TLR6 TLR5 TICAM2 TLR4 TLR2 RELB RELA TLR8 TLR1 IRAK1 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA%WIKIPATHWAYS_20260510%WP111%HOMO SAPIENS Electron transport chain OXPHOS system in mitochondria SDHA SLC25A4 SLC25A5 NDUFA12 COX6A2 ATP5IF1 SLC25A14 COX7A2L-1 NDUFB3 SLC25A27 NDUFA10 ATP5F1C NDUFB9 NDUFA11 SDHB COX7B COX15 NDUFC1 NDUFS8 COX4I1 NDUFS7 NDUFS6 UQCRB COX7A2 NDUFS4 NDUFS3 COX5B COX6A1 NDUFS2 UQCR11 COX7C NDUFS1 UQCR10 NDUFB8 COX5A NDUFB7 UQCRQ NDUFB10 UQCRC1 NDUFB6 COX8A NDUFB5 UQCRC2 NDUFB4 NDUFB2 SURF1 ATP5MC2 NDUFA4 UQCRFS1 ATP5MC3 COX6C COX6B1 NDUFB1 COX17 ATP5MC1 ATP5F1A ATP5F1B NDUFC2;NDUFC2-KCTD14 COX11 NDUFV3 NDUFV2 NDUFV1 ATP5MG ATP5ME NDUFA9 DMAC2L NDUFA8 SDHC ATP5PF SDHD NDUFA7 ATP5PD NDUFA6 NDUFA5 SCO1 ATP5PB NDUFA3 ATP5F1D NDUFAB1 SLC25A6 UCP3 ATP5PO NDUFS5-1 UCP2 NDUFA13 UCP1 ALBUTEROL AND BUDESONIDE THERAPY FOR ASTHMA%WIKIPATHWAYS_20260510%WP5503%HOMO SAPIENS Albuterol and budesonide therapy for asthma ADCY9 MYL2 PRKAR1B PLCB3 PRKAR1A ADCY4 ADRB2 PLCB1 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 PRKAR2A ADCY5 PRKACB-1 MYL1 MYL3 CREB1 PLCB4 MYL4 NR3C1 PLCB2 PRKACA-1 GNAS-1 INTERLEUKIN 1 INDUCED ACTIVATION OF NF KB%WIKIPATHWAYS_20260510%WP3656%HOMO SAPIENS Interleukin 1 induced activation of NF kB TIFA PRKCZ UBE2N IL1A IRAK1 TRAF6 AJUBA UBE2V1 SQSTM1 NFKB1 HAIR FOLLICLE DEVELOPMENT CYTODIFFERENTIATION STAGE 3 OF 3%WIKIPATHWAYS_20260510%WP2840%HOMO SAPIENS Hair follicle development cytodifferentiation stage 3 of 3 SOX2 EGR2 CTNNB1 MSX2 FOSB NOTCH2 TCF4 NOTCH1 JUN NFKB1 FOXE1 SMAD4 BMP6 KITLG SOSTDC1 CD34 GAS1 KRT15 BMPR1A LEF1 EGFR LHX2 S100A4 HR KLK6 HOXC12 PROM1 PHLDA1 DKK4 SPINK6 PERP SPINK5 KRTAP3-2;KRTAP3-3-1 ADAMTS20 ZBTB16 KRTAP8-1 DSG1 DSG4 DLX3 KLK5 CD200 KLK4 CASP14 KLK7 CUX1 LRIG1 GSDMA KLK13 KLK14 FOXN1 KRT19 KRTAP2-2;KRTAP2-1;KRTAP2-3;KRTAP2-4-2 LGR5 WIF1 IGF1 GPRC5D DSC2 BCL11B RUNX3 FOS SOX9 IFNG CCN2 ELANE IGFBP5 GJB6 DKK3 ADAM17 RBPJ GATA3 NFATC1 NR3C1 TP63 FZD1 WNT5A GTPBP4 SMAD1 FST BMP4 MSX1 DKK1 SFRP1 GLI2 FOXQ1 SARS COV 2 AND COVID 19 PATHWAY%WIKIPATHWAYS_20260510%WP4846%HOMO SAPIENS SARS CoV 2 and COVID 19 pathway ACE2 ACAT1 CTSV;CTSL SLC6A19 TLR7 NRP1 TMPRSS4 SCARB1 TMPRSS2 FURIN FAMILIAL PARTIAL LIPODYSTROPHY%WIKIPATHWAYS_20260510%WP5102%HOMO SAPIENS Familial partial lipodystrophy LPL CEBPA FNTA BANF1 ICMT PPARA CIDEC AKT2 KLF2 KLF5 LMNA SREBF1 GATA2 INS;INS-IGF2 PIK3CA PPARG CIDEA GATA3 LMNB2 LIPE FABP4 MAPK9 STAT5B ZMPSTE24 PRRX1 LMNB1 PLIN1 KLF9 MGLL PNPLA2 OVERVIEW OF NANOPARTICLE EFFECTS%WIKIPATHWAYS_20260510%WP3287%HOMO SAPIENS Overview of nanoparticle effects HMOX1 IL6 CDH3 PIK3CD PTGS2-2 PTGS1 BCL2 NFRKB LAMA3 FN1 CXCL8 AKT3 BAX CRP CCND3 TNF COL4A1 ITGAD PTK2 APOE AND MIR 146 IN INFLAMMATION AND ATHEROSCLEROSIS%WIKIPATHWAYS_20260510%WP3926%HOMO SAPIENS ApoE and miR 146 in inflammation and atherosclerosis SPI1 IRAK1 TLR4 TLR2 NFKB2 TRAF6 APOE RELA METABOLISM OF TETRAHYDROCANNABINOL THC %WIKIPATHWAYS_20260510%WP4174%HOMO SAPIENS Metabolism of tetrahydrocannabinol THC CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 GLYCOLYSIS AND GLUCONEOGENESIS%WIKIPATHWAYS_20260510%WP534%HOMO SAPIENS Glycolysis and gluconeogenesis HK1 LDHA GAPDH-1 PKM ALDOB PGK1 ALDOA PFKM SLC2A4 GOT1-1 GOT2-1 MDH2 SLC2A2 HK2 PDHA1 MDH1 PFKL G6PC1 PC SLC2A5 ENO2 ENO3 DLAT MPC1 PCK1 MPC2 PFKP ALDOC FBP2 PKLR GCK LDHA;LDHC LDHAL6B HK3 LDHB GPI PGAM1 TPI1 PGAM2 SLC2A1 FBP1 ENO1 DLD TCA CYCLE IN SENESCENCE%WIKIPATHWAYS_20260510%WP5050%HOMO SAPIENS TCA cycle in senescence FH TP53 PDHA1 MDH1 ME1 GOT1-1 PDP2 BRAF ME2 PDK1 DISORDERS OF FOLATE METABOLISM AND TRANSPORT%WIKIPATHWAYS_20260510%WP4259%HOMO SAPIENS Disorders of folate metabolism and transport ST20-MTHFS;MTHFS ALDH1L1 TYMS FTCD ATIC SLC19A1 FOLR1 MTHFR SHMT2 ALDH1L2 MTHFD1 MTHFD2 MTHFD2L GART QDPR SHMT1 SLC46A1 DHFR2;DHFR MTR-1 IRON SULFUR CLUSTER BIOGENESIS%WIKIPATHWAYS_20260510%WP5152%HOMO SAPIENS Iron sulfur cluster biogenesis ISCU NARF ABCB7 NUBP1 NUBP2 NFS1 LYRM4 FDX1 GLRX5 FDXR CIAO2B FXN HSPA9 HSCB NFU1 PATHWAYS OF NUCLEIC ACID METABOLISM AND INNATE IMMUNE SENSING%WIKIPATHWAYS_20260510%WP4705%HOMO SAPIENS Pathways of nucleic acid metabolism and innate immune sensing CGAS MAVS IFIH1 STING1 IFNB1-4 DDX58 IRF3 ADAR RNASEL RNASEH2C RNASEH2B RNASEH2A RNASET2 SAMHD1 TREX1 OAS1 MITOCHONDRIAL COMPLEX I ASSEMBLY MODEL OXPHOS SYSTEM%WIKIPATHWAYS_20260510%WP4324%HOMO SAPIENS Mitochondrial complex I assembly model OXPHOS system NDUFC1 NDUFAF2 NDUFS6 NDUFS4 NDUFAF1 NDUFS3 NDUFS2 NDUFS1 NDUFB8 NDUFB7 NDUFB10 NDUFB6 NDUFB5 NDUFB4 NDUFB2 NDUFB1 NDUFC2;NDUFC2-KCTD14 NDUFV3 NDUFV2 NDUFB11 NDUFV1 NUBPL DMAC2 FOXRED1 TMEM186 TMEM70 NDUFA8 NDUFAF6 NDUFAF4 NDUFA7 NDUFAF3 TMEM126B NDUFA6 NDUFA5 NDUFA3 NDUFA12 NDUFAB1 NDUFAF7 NDUFS5-1 NDUFB3 NDUFA10 ECSIT NDUFA13 ACAD9 TIMMDC1 NDUFB9 TYPE III INTERFERON SIGNALING%WIKIPATHWAYS_20260510%WP2113%HOMO SAPIENS Type III interferon signaling STAT1 IRF9 IL10RB STAT2 IFNLR1 JAK1 IFNL2;IFNL3;IFNL1 TYK2 MIRNA DEGRADING ENZYMES%WIKIPATHWAYS_20260510%WP4316%HOMO SAPIENS miRNA degrading enzymes PNPT1 XRN1 EXOSC4 P38 MAPK SIGNALING%WIKIPATHWAYS_20260510%WP400%HOMO SAPIENS p38 MAPK signaling GRB2 MAP3K9 HMGN1 HSPB1 SHC1-1 ATF2 MYC DDIT3 TRADD RASGRF1 ELK1 MAP2K4 DAXX TGFBR1-1 RAC1 HRAS MAP3K1 MAP3K5 CDC42 MAPKAPK2 TRAF2 MAP2K6 RPS6KA5 MEF2D TGFB2 CREB1 RIPK1 SMIM40 MAPKAPK5 MAP3K7 STAT1 PLA2G4A MAX MAPK14 MKNK1 LACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260510%WP5303%HOMO SAPIENS Lacto series sphingolipid metabolism B3GALT2 B3GNT5 FUT1 B3GALT1 FUT2 FUT6;FUT5;FUT3 TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260510%WP75%HOMO SAPIENS Toll like receptor signaling CXCL10 CXCL11 TAB1 CCL3L1;CCL3L3;CCL3;CCL18 CXCL9 AKT2 AKT3 NFKBIB IRAK4 IKBKB NFKBIA JUN IFNAR2 CHUK MAP3K8 TRAF6 MAPK1 IKBKG NFKB1 MAPK12 MAP2K6 IFNAR1 MAPK11 CASP8 RIPK1 FADD IFNB1-4 TLR2 MAP2K3 MAP3K7 STAT1 TNF TAB2 IL6 TOLLIP TBK1 IKBKE TRAF3 TICAM1 MYD88 IRF3 IRF7 IL1B TLR7 TLR3 CD80 CXCL8 MAP2K4 LY96 RAC1 TAB3 AKT1 TIRAP IL12B FOS IL12A TLR9 TLR6 TLR5 MAP2K7 TICAM2 TLR4 CD14 MAPK10 RELA CD40 SPP1 IRF5 MAPK9 MAPK8 TLR8 MAP2K2;MAP2K1 CCL4L2;CCL4L1;CCL4 MAPK13 TLR1 CCL5 IRAK1 MAPK3 CD86 LBP MAPK14 LEUKOTRIENE METABOLIC PATHWAY%WIKIPATHWAYS_20260510%WP5171%HOMO SAPIENS Leukotriene metabolic pathway DPEP1 GGT1 ABCC1 DECR2 DECR1 LTC4S ALOX5AP DPEP2 LTA4H ALOX5 PTGR1-1 GGT5 CYP4F3;CYP4F2;CYP4F12;CYP4F11 EBSTEIN BARR VIRUS LMP1 SIGNALING%WIKIPATHWAYS_20260510%WP262%HOMO SAPIENS Ebstein Barr virus LMP1 signaling TRAF1 IFNB1-4 CCL20 RELA CXCL8 TRADD MAP3K7 MAP3K3 MAPK8 IKBKB CCL5 TNF NFKBIA IRAK1 PDLIM7 NFKB2 CHUK TRAF6 HSP90AA1 MAPK1 IKBKG MAP3K14 NFKB1 UDP DERIVED SUGARS SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260510%WP5394%HOMO SAPIENS UDP derived sugars synthesis in fibroblasts HK1 GALE GFPT1 PGM1 HK3 UGDH UXS1 PGM3 GPI GCK HK2 DIET DEPENDENT TRIMETHYLAMINE TRIMETHYLAMINE N OXIDE METABOLISM %WIKIPATHWAYS_20260510%WP5219%HOMO SAPIENS Diet dependent trimethylamine trimethylamine N oxide metabolism CHDH FMO3 SLC44A1 ALDH7A1 PURINERGIC SIGNALING%WIKIPATHWAYS_20260510%WP4900%HOMO SAPIENS Purinergic signaling P2RY1 P2RY13 ADORA2A P2RY11 GNAZ LPAR4 LPAR6 GNAI3 GNAI1 GNAI2 P2RY6 GNAO1 P2RY4 GNA11 ADORA2B P2RY2 ADORA3 P2RY8 GNAT2 GNAT3 GNAT1 P2RY12 P2RY10 P2RY14 P2RX7 P2RX6 P2RX5 P2RX4 P2RX3 P2RX2 P2RX1 ADORA1 PANX1 GNAS-1 TCA CYCLE AKA KREBS OR CITRIC ACID CYCLE %WIKIPATHWAYS_20260510%WP78%HOMO SAPIENS TCA cycle aka Krebs or citric acid cycle SDHB SDHC IDH3A SDHD ACO2 SUCLA2 SUCLG1 MDH2 FH IDH3G DLST IDH3B SDHA IDH2 CS OGDH SUCLG2 DLD MITOCHONDRIAL BETA OXIDATION%WIKIPATHWAYS_20260510%WP5241%HOMO SAPIENS Mitochondrial beta oxidation ACAA2 ECI1 DECR1 ACADL HSD17B10 EHHADH-1 ECHS1 ACADSB ACSL3 GLYCOSAMINOGLYCAN DEGRADATION%WIKIPATHWAYS_20260510%WP4815%HOMO SAPIENS Glycosaminoglycan degradation HEXA HYAL1 HYAL2 HYAL4 IDS HPSE GUSB NAGLU ARSB GLB1 HGSNAT HPSE2 IDUA GNS SGSH HEXB GALNS MAPK SIGNALING%WIKIPATHWAYS_20260510%WP382%HOMO SAPIENS MAPK signaling MAP3K6 RASGRP1 TAB1 CDC25B RASGRP2 NLK RASA1 IKBKB MAP3K1 RRAS CHUK MAP3K8 TRAF6 MAPK1 IKBKG RAF1 MAP3K14 MAP4K2 NFKB1 MAP2K6 RPS6KA5 TGFB2 MAP4K3 TGFB3 MAP4K4 TAOK2 STK3 BDNF MAPKAPK5 PRKCG PRKCD PRKCA CACNB1 MKNK1 CACNB3 MKNK2 FLNB FLNC HSPA8 CACNA1B CACNA1A STK4 CACNA1D FLNA CACNA1C SRF CACNA2D3 RASGRF1 CACNA2D2 ELK4 CACNA2D4 CACNA1E CACNB2 CACNB4 STMN1 CACNA1F MAPKAPK3 CACNG6 MAPKAPK2 CACNG7 CACNG8 CACNA1S CACNG1 CACNG3 CACNG4 TAOK1 CACNG5 MAPK13 ARRB1 ARRB2 HSPA6 PRKACA-1 HSPA1L NFATC3 MAPK8IP3 DUSP8 DUSP9 ATF2 DUSP7 RAPGEF2 TAOK3 MAP3K20 MEF2C DUSP16 PPM1A PTPN7 DAXX MAP3K11 PRKACB-1 FASLG MAPK12 MAPK11 LAMTOR3 SMIM40 MAP3K4 ECSIT TNF MAPT PPM1B MAPK8IP1 CRKL ELK1 MAP2K4 HSPA1A;HSPA1B CASP3 AKT1 DUSP3 DUSP4 MAP3K5 CRK PTPN5 FOS MAP2K7 NGF PAK2 EGF MAPK10 RELB RELA CACNA1H PDGFA FGF1 RAP1B MAPK9 MAPK8 MAP2K2;MAP2K1 FAS MAPK7 MAPK3 NTF3 TGFB1 JUND BRAF MAPK14 JMJD7-PLA2G4B;PLA2G4B NR4A1 TGFBR2 RASGRF2 DDIT3 PLA2G4F PLA2G4D PLA2G4E RASA2 JUN NFKB2 TRAF2 CACNG2 CACNA2D1 MAP2K3 HSPA2 MAP2K5 MAPK8IP2 ATF4 RPS6KA3 PLA2G4A DUSP10 FGF2 FGF3 FGF4 FGF5 FGF6 DUSP2 FGF7 FGF8 FGF9 LRRK2 PPP3CC PDGFB IL1R1 FGF20 IL1A CD14 TNFRSF1A FGF23 FGF22 FGF21 FGF17 FGF16 RPS6KA4 FGF14 MAX MAP3K13 FGF19 MAP3K12 FGF18 FGF13 FGF12 PTPRR FGF11 FGF10 RAC3 RRAS2 MAP4K1 MYC AKT2 MRAS AKT3 HRAS PDGFRB CDC42 GNA12 RASGRP4 RASGRP3 SOS1 SOS2 TP53 RAP1A EGFR MAP3K7 NTRK1 NTRK2 TAB2 DUSP6 KRAS GRB2 FGFR4 FGFR3 FGFR2 HSPB1 FGFR1 IL1B ARAF MAP3K2 TGFBR1-1 RAC1 CACNA1G PPP3CB PPP3CA NRAS PAK1 DUSP1 PPP3R1 GADD45A NF1 NFATC1 PPP5C IL1R2 CACNA1I NTF4 OXIDATION BY CYTOCHROME P450%WIKIPATHWAYS_20260510%WP43%HOMO SAPIENS Oxidation by cytochrome P450 CYP2W1 CYP1A1 CYP4F22 CYP2C9;CYP2C19 CYP8B1 CYP20A1 CYP2E1 CYP7A1 CYP2B6 CYP1A2 CYP4X1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP27B1 CYP24A1 CYP11B1;CYP11B2 CYP17A1 CYP26A1 CYP51A1 CYP27C1 CYP2S1 CYB5R2 CYB5R1 CYB5R4 CYB5R3 CYP19A1 CYP26B1 CYP4V2 CYP2R1 CYP1B1 CYP46A1 POR CYB5A CYP2J2-1 CYP2C18-1 CYP2F1 CYP11A1 CYP4B1 CYP7B1 CYP27A1 CYP39A1 CYP2D6;LOC107987479;LOC107987478-1 CYP2U1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 CYP2A13;CYP2A6;CYP2A7-1 ALPHA 6 BETA 4 SIGNALING%WIKIPATHWAYS_20260510%WP244%HOMO SAPIENS Alpha 6 beta 4 signaling GRB2 SHC1-1 ITGA6 IRS2 IRS1 GAB1 RAC1 HRAS AKT1 ITGB4 MAPK1 PIK3R2 RHOA PIK3R1 EIF4EBP1 SOS1 LAMC2 LAMA5 LAMA2 SRC LAMA1 PTPN11 LAMA3 LAMB3 LAMB2 LAMC1 LAMB1 MAPK3 PRKCD PRKCA MTOR MAPK14 PTK2 DEVELOPMENT OF URETERIC DERIVED COLLECTING SYSTEM%WIKIPATHWAYS_20260510%WP5053%HOMO SAPIENS Development of ureteric derived collecting system RARG GDNF CCND1 ETV4 RARB PAX2 SIX2 SMO SPRY1 HOXD11 BMPER HOXA11 GPC3 CRIM1 SALL1 CTDNEP1 EYA1 FRAS1 FREM1 GFRA1 FREM2 ETV5 BMP5 RET GRIP1 GDF11 CELSR1 BMP7 RARA WNT11 TGFB2 ANOS1-1 MYCN BMPR1A BMPR2 SHH SIX1 SMAD1 FST BMP4 TGFB1 GLI1 DCN GLI3 ITGA8 GLI2 BMP2 VANGL2 MIR TARGETED GENES IN SQUAMOUS CELL%WIKIPATHWAYS_20260510%WP2006%HOMO SAPIENS miR targeted genes in squamous cell ACAA2 PRPF40A ARF4-1 TGFBR2 NF2 PEDS1-UBE2V1;PEDS1 GOLGA7-1 PISD RAB34 ADIPOR2 MAP3K8 RTN4 CPNE8 MRPL20 PODXL VEZT SRPRB-1 PWP1 ATP6V1F CIAO2A TBCA FNDC3B FNDC3A TRAM1 TMED2-1 DHX40 ADAR MRC2 TMEM43 UBE2J1 COMMD9 SH3BGRL3 ATP6V1C1 MOV10 PDLIM7 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A ANP32B THBS1 POM121;POM121C DNAJB1 MAGT1 PNP-1 SLC12A2 HMOX1 TMED7 TXNRD1 CSDE1 AP3D1 FGF2 PXDN ARCN1 PTMA FMNL2 ATP6V0E2;ATP6V0E1 MPZL1 SLC38A2 SPCS3 NEDD4 GYS1 LAMTOR5 HES1 POGLUT3 SLC38A1 RARS1 ATRX TPM1 AKAP8 POLD2 RAI14 GFPT1 PPP1R7 SLC4A10 ATP2A2 TPM3 CHMP2A SH3BP4 SMAD1 SYNE2 CBFB YWHAQ TMEM59 MTPN SEC23A SIGMAR1 HSD17B12 DHX57 ARFIP1 ELOVL5 FBXW11 GALNT7 MRPS33 GALNT1 CUL4B GAS2L1 PDCD4 BET1 AP2A1 IDH1 GNAI2 ANXA2 HOXA7 ANPEP MET P4HA2 PICALM LAMC1 CTDSP1 RHEB PKM SPTLC1 SDCBP POLR2C SRSF9 TUBA1A TMED10 NCL-1 E2F3 NRP1 HNRNPM AXL VCAM1 NCRNAS INVOLVED IN STAT3 SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260510%WP4337%HOMO SAPIENS ncRNAs involved in STAT3 signaling in hepatocellular carcinoma IL6 RELA SOX4 JAK1 JAK3 JAK2 IL11RA IL6R IL11 IL6ST ZEB1 STAT3 NFKB1 AGE RAGE PATHWAY%WIKIPATHWAYS_20260510%WP2324%HOMO SAPIENS AGE RAGE pathway SP1 ALPL ATF2 FOXO4 IRS1 JAK2 IRAK4 AGER IKBKB ROCK1 NFKBIA JUN INS;INS-IGF2 CHUK MMP7 FOXO1-1 CDC42 MAPK1 RAF1 MSR1 NOS2 NFKB1 SMAD2;SMAD3 CASP8 SRC STAT5A EGFR STAT5B STAT1 INHBB PLA2G4A PRKCB INSR PRKCD PRKCA STAT3 MMP2 MMP9 NCF1 MYD88 SHC1-1 CASP9 PRKCZ DDOST RAC1 CASP3 AKT1 TIRAP LGALS3 EZR RHOA MMP13 CYCS-1 HIF1A RELA MAPK9 MSN MAPK8 MAP2K2;MAP2K1 SOD1 MAPK3 DIAPH1 MMP14 NOS3 MAPK14 MIRNA ROLE IN IMMUNE RESPONSE IN SEPSIS%WIKIPATHWAYS_20260510%WP4329%HOMO SAPIENS miRNA role in immune response in sepsis REL GZMH;GZMB-1 IL6 ICAM1 TRAF3 TAB1 MYD88 CCL3L1;CCL3L3;CCL3;CCL18 IRF7 TLR7 CXCL8 LCN2 IRAK4 IKBKB NFKBIA IRF1 NFKB2 CHUK TRAF6 IKBKG NFKB1 ELANE IL1A TLR4 RELB RELA IRF5 MAP3K7 MAPK8 TLR8 CCL4L2;CCL4L1;CCL4 TNF IRAK1 IL10 TAB2 VCAM1 MAPK14 BDNF TRKB SIGNALING%WIKIPATHWAYS_20260510%WP3676%HOMO SAPIENS BDNF TrkB signaling KRAS GRB2 PIK3CG SHC1-1 TRPC6 GAB1 HRAS ADCY1 AKT1 TSC2 TSC1 MAPK1 EIF4EBP1 CREB1 NRAS SOS1 ARC EEF2K BDNF MAP2K2;MAP2K1 HOMER1 RPS6KB1 PLCG1 NTRK2 GRIN1 RPS6KA1 DLG4 GAB2 MTOR BRAF TRPC3 MKNK1 RHEB ATM SIGNALING%WIKIPATHWAYS_20260510%WP2516%HOMO SAPIENS ATM signaling CHEK1 MDC1 CDC25C ATF2 CASP2 MDM4 BRCA1 JUN CCNB1 IKBKG TLK1 MRE11 TP53BP1 CREB1 RIPK1 RAD50 RAD51 BID TP53 NBN RAD9A CDK2 MDM2-2 GADD45A CDK1 MAPK9 PIDD1 CDC25A SMC1A CCNE1 ABL1 ATM TP73 CRADD CHEK2 CDKN1A PENTOSE PHOSPHATE METABOLISM%WIKIPATHWAYS_20260510%WP134%HOMO SAPIENS Pentose phosphate metabolism RPIA PGLS TKT G6PD TALDO1 RPE;RPEL1 PGD ANGIOGENESIS%WIKIPATHWAYS_20260510%WP1539%HOMO SAPIENS Angiogenesis FLT1 PDGFB MMP9 TEK ARNT FGFR2 HIF1A FGF2 SRC TIMP3 KDR CREBBP PDGFRA AKT1 PLCG1 SMAD1 VEGFA TIMP2 PIK3CA MAPK1 NOS3 ANGPT1 MAPK14 PTK2 SPHINGOLIPID METABOLISM IN SENESCENCE%WIKIPATHWAYS_20260510%WP5121%HOMO SAPIENS Sphingolipid metabolism in senescence CERS2 SPTLC1 S1PR5 PLCB1 SGPP1 TERT CDK4 DEGS1 MAPK1 SMPD3 GBA E2F1 CDK2 GLB1 CERS4 ASAH1 RPP38 S1PR1 RB1 S1PR2 PRKCB SPHK1 SGMS2 UGCG PRKCA MTOR KDSR CDKN1A WNT BETA CATENIN SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260510%WP5529%HOMO SAPIENS Wnt Beta catenin signaling and ARTD family members PARP10 SKP1 PLK1 TNK1 RBX1 CTNNB1 DVL1 DVL2 DVL3 CUL1 AXIN1 TNK2 BTRC PARP1 APC GLYCOSYLATION AND RELATED CONGENITAL DEFECTS%WIKIPATHWAYS_20260510%WP4521%HOMO SAPIENS Glycosylation and related congenital defects DPAGT1 ALG1 MPI GMPPB DPM1 TUSC3 ALG8 ALG9 ALG6 ALG2 ALG14 ALG3 MOGS ALG12 ALG11 DPM3 B4GALT1 PMM2 MAGT1 MGAT2 SRD5A3 MPDU1 DOLK DPM2 PREGNANE X RECEPTOR PATHWAY%WIKIPATHWAYS_20260510%WP2876%HOMO SAPIENS Pregnane X receptor pathway CYP2C9;CYP2C19 NR1I2 CYP2B6 RXRA CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SRPX2 NCOA3 NCOA2 FOXO1-1 HSP90AA1 PSMC5 NRIP1 DNAJC7 NCOA1 SULT2A1-4 UGT1A1;UGT1A6 PPARGC1A ABCB1 SRC GSTA3;GSTA5;GSTA1;GSTA2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC3 ABCC4 ABCC2 CYP4F3;CYP4F2;CYP4F12;CYP4F11 CYP2A13;CYP2A6;CYP2A7-1 PPAR SIGNALING%WIKIPATHWAYS_20260510%WP3942%HOMO SAPIENS PPAR signaling APOA5 LPL CYP8B1 CYP7A1 FABP1 RXRB RXRA CPT2 SCP2 RXRG ACOX1 PPARA PLTP ACSL1 OLR1 FADS2 MMP1 PDPK1 SCD ILK CD36 PCK2 PPARG ADIPOQ PCK1 SLC27A4 GK PPARD LOC100509620;LOC112267859;AQP7 FABP3 FABP4 CPT1C SORBS1 SLC27A1 ME1 HMGCS2 PLIN1 EHHADH-1 CYP27A1 APOA2 ACAA1-1 UCP1 NR1H3 UBB;UBC APOA1 ANGPTL4 SLC27A5 APOC3 ARIPIPRAZOLE METABOLIC PATHWAY%WIKIPATHWAYS_20260510%WP2640%HOMO SAPIENS Aripiprazole metabolic pathway CYP2D6;LOC107987479;LOC107987478-1 GLYCEROPHOSPHOLIPID BIOSYNTHETIC PATHWAY%WIKIPATHWAYS_20260510%WP2533%HOMO SAPIENS Glycerophospholipid biosynthetic pathway PEMT PIK3CD PIK3CB CDIPT PIK3CG MOGAT3 LPIN1 GNPAT GPAM AGPS PI4K2A PIK3CA PGS1 GPAT3 GPAT2 LPIN2 PTPMT1 CDS2 PIP5K1A IPMK GK CRLS1 GPAT4 GPD1 CHPT1 CHKB PLA2G2A-1 PCYT2 PTDSS1 CEPT1 P53 TRANSCRIPTIONAL GENE NETWORK%WIKIPATHWAYS_20260510%WP4963%HOMO SAPIENS p53 transcriptional gene network TRAF4 ERCC5;BIVM-ERCC5 MSH2 PTEN ICAM1 BTG2 SESN1 CDC25C SESN2 TP53INP1 RPTOR DDIT4 DEPTOR SERPINE1 PRKAA1 MLST8 NOTCH1 PMAIP1 POLH CCNG1 TSC2 APAF1 FUCA1 FASLG AKT1S1 FANCC BBC3 ACAD11 SERPINB5 ULK2 PRKAB2 SCO2 NANOG;NANOGP8 PRKAB1 ADGRB1 E2F7 ULBP1-2 DRAM1 RPRM ULBP3;ULBP1;RAET1G;ULBP2;RAET1L SIVA1 GLS2 TP53I3 CDK2 ULK1 PIDD1 PRKAG1 PRKAG2 PRKAG3 RRM2B ZMAT3 TNF PERP TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A TIGAR THBS1 MTOR PML SLC2A1 SLC7A11 GPX1 PCNA NCF2 AURKA ISG15 CX3CL1 SAT1 POLK MLH1 DDB2 SFN ADORA2B LIF IRF9 XRCC5 PRKAA2 GADD45A IRF5 CCL13;CCL2 MGMT BAX CPT1C CDC25A CCNE1 FAS ALDH4A1 XPC CDKN1A CEREBRAL ORGANIC ACIDURIAS INCLUDING DISEASES%WIKIPATHWAYS_20260510%WP4519%HOMO SAPIENS Cerebral organic acidurias including diseases ADHFE1 D2HGDH GCDH L2HGDH IDH2 MDH2 ACY1;ABHD14A-ACY1 ALDH7A1 ANDROGEN BIOSYNTHESIS%WIKIPATHWAYS_20260510%WP5393%HOMO SAPIENS Androgen biosynthesis POR SULT2A1-4 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 HSD3B1;HSD3B2 CYP11B1;CYP11B2 HSD17B4 CYP17A1 HSD11B1 AKR1D1 HSD11B2 HSD17B3 HSD17B1 HSD17B2 SRD5A2 SRD5A1 NO CGMP PKG MEDIATED NEUROPROTECTION%WIKIPATHWAYS_20260510%WP4008%HOMO SAPIENS NO cGMP PKG mediated neuroprotection CNGA1 NOS1 GRIN2C CNGB1 CAMK2B CAMK2D IL1B BCL2 CAMK2A ACTN2 CASP9 GUCY1B1 NFKBIA AKAP9-1 NEFL TSPO NOS2 NFKB1 GRIN2A PDE2A CREB1 IFNG NPPB CAMK2G PPID XIAP NPPA CYCS-1 GRIN2D CNGA2 BAD RELA CNGA3 CNGA4 CNGB3 CALM1 NPR1 GRIN2B TNF PRKG2 GRIN1 DLG4 PDE3A GUCY1A2 GUCY1A1 NOS3 RESOLVIN E1 AND RESOLVIN D1 SIGNALING DECREASE INFLAMMATION%WIKIPATHWAYS_20260510%WP5191%HOMO SAPIENS Resolvin E1 and resolvin D1 signaling decrease inflammation PIK3CD FPR2 AKT1 PIK3CB PIK3CG LTB4R PIK3CA GRK1 EPHB2 MTOR PDK1 CMKLR1 PROGERIA ASSOCIATED LIPODYSTROPHY%WIKIPATHWAYS_20260510%WP5103%HOMO SAPIENS Progeria associated lipodystrophy SMAD4 POLD1 FNTA KCNJ6 ICMT BANF1 WRN LMNB2 MUCL3 SPRTN LMNA RECQL ZMPSTE24 FFAR3;GPR42 TGFB1 LMNB1 INS;INS-IGF2 PARP1 PPARG SMAD2;SMAD3 FBN1 22Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP4657%HOMO SAPIENS 22q11 2 copy number variation syndrome GP1BA RBX1 NKX2-5 BCL2 PPP1CB ACTC1;ACTG2 CUL3 ALDH1A2 XPO1 RTN4 RAF1 CBX5 MALT1 PLK1 ACTA2 SLC25A1 MED15 CLTCL1 SREBF2 CDH15 ASF1A CHRD H4C1 TXNRD2 SHOC2 CDC45 CLDN3 SRF FGF8 SREBF1 SEPTIN5 HES1 PRKN TBX1 UFD1 GBX2 P2RX6 COMT FOXA2 CLDN5 ALDH4A1 OAT PRODH;LOC102724788 FGF10 HAND2 HIRA KPNB1 RELN CYP26A1 POLR2A DGCR8 CLDN1 DROSHA RAN FOXC1 CYP26B1 NCOR1 CDC42 PAX3 TP53 HIRIP3 EGFR TSKS ZDHHC8 PITX2 ZNF274;ZNF74 RCC1 TANGO2 C22orf39 THAP7 TSSK2 RTL10 NPRL2 NPRL3 TRMT2A ESS2 KLHL22 GP5 LZTR1 GLUD1;GLUD2 LRRC74B AIFM3 MRPL40 SCARF2 EMC10 TNPO1 DGCR2 VWF FGFR2 SEPTIN11-1 SLC2A4 GP1BB FGFR1 RANGAP1 SLC7A4 GNB1L DEPDC5 CRKL CCDC188 ARVCF SERPIND1 LOC102724770;DGCR6;DGCR6L RANBP1 SEPTIN8 RORC SNAP29 PAK4 ARNTL PI4KA SHH FOXC2 GP9 HDAC3 MAG RTN4R DRD2 GSC2 INTEGRATIVE ANALYSIS OF TREG GLIAL INTERACTIONS %WIKIPATHWAYS_20260510%WP5561%HOMO SAPIENS Integrative Analysis of Treg Glial Interactions IL2 ITGAV CXCL12 CSPG4 CTLA4 IL2RB TGFBR2 FAM20C ROS1 FOXO4 CD28 PDCD1 AIF1 CCR8 CCR6 VEGFA NFKB2 CD44 CXCL2;CXCL3;CXCL1-1 NOS2 NFKB1 SMAD2;SMAD3 CCL1 IL12RB2 TGFB2 CD47 EBI3 CCL20 MBP MOG IL2RG JAK3 CASP1 MMP9 MYD88 IL10RB IL10RA IL1RAP LGALS3 IL12A GALC P2RY12 CD86 CD68 CD274 ITGA2 IGF1R TNFRSF1B OLIG1 PDGFRA STAT4 IL12RB1 FOXO1-1 CDC42 PLP1 LGALS1 TGM2 FOXO3 GSDMD JAK1 STAT5A STAT5B EGFR STAT1 TNF NLRP3 STAT3 IL18 OSM TGFBR3 IL6 IGF1 IL1B CD80 AREG IKZF2 TGFBR1-1 CCN3 RAC1 NKX6-2 MCAM TMEM119 SEMA3F IL33 KLRG1 SSTR2 CX3CR1 TYK2 FOXP3 SOX9 IFNG TLR4 OLIG2 SIRPA;SIRPB1;SIRPG SOCS3 SPP1 PDGFA HTR7 IL4 CD4 IL2RA TGFB1 IL10 NKX6-1 CNP NKX2-2 ITGB3 MAPK14 APOD PTK2 HEXB DNA REPLICATION%WIKIPATHWAYS_20260510%WP466%HOMO SAPIENS DNA replication PCNA UBA52 CDC45 PRIM2 MCM10 ORC5 POLA2 POLE ORC4 RFC5 RFC3 ORC6 RFC4 ORC1 ORC3 ORC2 POLD4 PRIM1 POLD1 CDC7 POLD3 POLD2 CDC6 CDK2 GMNN CDT1 MCM7 RPA1 RPA2 POLA1 DBF4 RPA3 POLE2 MCM3 MCM4 UBB;UBC RFC1 MCM5 MCM6 RFC2 MCM2 APOPTOSIS REGULATION BY PARATHYROID HORMONE RELATED PROTEIN%WIKIPATHWAYS_20260510%WP3872%HOMO SAPIENS Apoptosis regulation by parathyroid hormone related protein BCL2L10 BCL2L13 BID PIK3CG BCL2L1 GSK3A BAK1 BCL2 ITGA6 MYC GSK3B AKT2 AKT3 BAX BCL2A1 AKT1 BCL2L12 ITGB4 BCL2L14 BCL2L15 MCL1 BCL2L2 BOK PTHLH AGE RELATED MACULAR DEGENERATION%WIKIPATHWAYS_20260510%WP5526%HOMO SAPIENS Age related macular degeneration PRKAB2 PRKAB1 PPARGC1A PRKAA2 RPTOR PRKAA1 PARP2 SIRT1 MLST8 PMAIP1 PRKAG1 PRKAG2 RPS6KB1 PRKAG3 MAPK3 MDH1 MTOR CONSTITUTIVE ANDROSTANE RECEPTOR PATHWAY%WIKIPATHWAYS_20260510%WP2875%HOMO SAPIENS Constitutive androstane receptor pathway CYP2C9;CYP2C19 CYP2B6 PTPA RXRA CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ALAS1 SP1 NCOA2 FOXO1-1 HSP90AA1 DNAJC7 NCOA1 SULT2A1-4 UGT1A1;UGT1A6 PPARGC1A ABCB1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 NR1I3 GSTA3;GSTA5;GSTA1;GSTA2 ABCC3 ABCC2 SMC1A NCOA6 EHHADH-1 CYP2A13;CYP2A6;CYP2A7-1 AXON GUIDANCE%WIKIPATHWAYS_20260510%WP5289%HOMO SAPIENS Axon guidance CXCL12 FYN L1CAM RGMA RASA1 PTCH1 ENAH ROBO2 RYK-1 SLIT1 SLIT3 GDF7 HRAS SLIT2 ROCK1 ROBO1 GNAI1 RRAS CDC42 MAPK1 RHOD RAF1 BOC MET ARHGEF12 DCC EPHA2 BMPR1B SRC EPHB1 BMPR2 EFNA1 PARD3 NGEF PRKCA NTN4 TRPC1 NTN3 GSK3B NCK1 FES PDPK1 PRKCZ RAC1 ILK CFL1 MYL12B SEMA5B ROBO3 DPYSL5 SEMA6C UNC5D SEMA7A EFNB1 ABLIM3 LRIG2 DPYSL2 LRRC4C SRGAP2 NTNG2 FZD3 PARD6A ITGB1 NRP1 SEMA3A PLXNA1 SHH CDK5 CXCR4 WNT5A ABL1 WNT4 NITRIC OXIDE METABOLISM IN CYSTIC FIBROSIS%WIKIPATHWAYS_20260510%WP4947%HOMO SAPIENS Nitric oxide metabolism in cystic fibrosis PRMT1 NOS1 PRMT8 PRMT7 PRMT3 DDAH2 PRMT5 CARM1 DDAH1 PRMT2 NOS3 NOS2 PRMT6 AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20260510%WP521%HOMO SAPIENS Amino acid conjugation of benzoic acid GLYAT ACSS2 CANCER IMMUNOTHERAPY BY CTLA4 BLOCKADE%WIKIPATHWAYS_20260510%WP4582%HOMO SAPIENS Cancer immunotherapy by CTLA4 blockade PIK3R1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 PIK3CD PIK3CB CTLA4 CD80 PTPN11 CD28 PTPN6 PPP2CB;PPP2CA PIK3CA CD86 PIK3R3 PIK3R2 CILIOPATHIES%WIKIPATHWAYS_20260510%WP4803%HOMO SAPIENS Ciliopathies GLIS2 CEP78 DNAH11 ARL2BP DNAL1 HYDIN TAPT1 CCDC39 DDX59 CFAP52 DNAI2 POMGNT1 TOPORS NME9 ZMYND10 KIZ CFAP53 SMO NEK9 KATNIP DNAJB13 CCDC103 DNAH6 POC1A POC1B RAB28 DNAI1 TUB RPGRIP1 DYNC2I2 TTLL5 DYNC2I1 HYLS1 TRAF3IP1 ATXN10 CEP19 IFT172 ALMS1 CEP120 DYNC2H1 CENPF IFT80 RPGRIP1L LZTFL1 IFT81 AHI1 WDPCP CEP104 ARL6 ARL3 RSPH9 TTBK2 DYNC2LI1 OCRL TTC21B INPP5E PIBF1 BBS2 CSPP1 BBS1 TMEM138 IFT122 RSPH3 CPLANE1 NPHP1 TMEM231 DRC1 TMEM17 MKS1 TMEM237 CEP83 IFT27 CEP164 KIAA0586 UNC119 B9D2 C2CD3 FLCN IFT52 TCTN3 TCTN2 TMEM107 TCTN1 BBS9 BBS7 RP1L1 IFT57 CC2D2A BBS5 BBS4 MKKS IFT140 GAS8 WDR35 BBS10 IFT43 EVC BBS12 TMEM216 CILK1 DYNLT2B PLK4 ARL13B TMEM67 RAB23 KIAA0753 TULP1 OFD1-1 EVC2 CCDC65 WDR19 SCLT1 TTC8 B9D1 CLUAP1 NME7 INTU ZNF423 KIF7 PIK3R4 BBIP1 ADCY6 GPR161 RSPH4A RSPH1 ANKS6 ZIC2 INVS CNGA1 NEK1 CFAP410 SPATA7 RP2 MAK NEK8 EFHC1 CNGB1 CRX PKD1L1 PKHD1 PDE6D NPHP3 USP9X PCARE DCDC2 C8orf37 CEP41 TRIM32 PKD2 PKD1 CEP290 IQCB1 CCDC40 LCA5 SPAG1 ODAD1 GALNT11 XPNPEP3 ODAD3 ODAD2 ODAD4 MCIDAS TBC1D32 NEK2 DNAAF3 DNAAF2 DNAAF1 DNAAF6 DNAAF5 DNAAF4 RP1-2 FAM161A CFAP298;CFAP298-TCP10L GLI3 CCNQ GLI2 CCNO AK7 METHIONINE METABOLISM LEADING TO SULFUR AMINO ACIDS AND RELATED DISORDERS%WIKIPATHWAYS_20260510%WP4292%HOMO SAPIENS Methionine metabolism leading to sulfur amino acids and related disorders CTH CSAD GNMT AHCY MAT2B MAT1A BHMT CBS;CBSL ADK MTR-1 CDO1 PI3K AKT SIGNALING%WIKIPATHWAYS_20260510%WP4172%HOMO SAPIENS PI3K Akt signaling VEGFC TCL1B IL3 ITGAV TCL1A PHLPP2 IL2RB CCNE2 EIF4E2 PPP2R3C PHLPP1 BRCA1 CDK6 EIF4B CDK4 ANGPT4 IKBKB COL4A2 CHUK MAPK1 IKBKG RAF1 NFKB1 CHRM2 CHRM1 IGF2 EFNA5 EFNA4 CDK2 BDNF ITGA5 EFNA1 EFNA3 EFNA2 RBL2 SGK3;C8orf44-SGK3 PRKCA THBS1 COL6A1 PRL GYS1 GNG13 GNB2 COL6A3 GNB1 CDC37 GNB4 GNB3 GNB5 ITGA10 PPP2CB;PPP2CA PKN3 PKN2 PKN1 HSP90B1 GNGT1 THEM4 ITGA2 PPP2R1B ITGB7 PPP2R1A PPP2R5B PPP2R5A PPP2R5D RELN PPP2R3B ATF2 PPP2R3A PPP2R2C PPP2R2B PPP2R2A;PPP2R2D IRS1 PIK3R6 PIK3R5 INS;INS-IGF2 MCL1 GNG2 FASLG GNG5 GNG4 GNG8 TNC BCL2L11 TLR2 BCL2L1 FOXO3 JAK1 SYK FLT3LG PRLR RPS6 LAMC1 RPS6KB1 RPS6KB2 OSM VTN IL6 ITGA3 ITGA6 GSK3B CD19 CASP9 PDPK1 AKT1 HSP90AA1 TGFA IBSP COMP EIF4EBP1 TNN CREB1 TNR NGF CHAD TLR4 COL2A1 EGF COL6A2 PRKAA2 ITGB1 LAMA5 RELA THBS4 SPP1 THBS3 PDGFA TNXB FGF1 COL1A1 MAP2K2;MAP2K1 MAPK3 NTF3 NOS3 PPP2R5E PPP2R5C PTK2 IL2 STK11 DDIT4 BCL2 PIK3AP1 PRKAA1 EIF4E VEGFA IFNAR2 PIK3CA PCK2 ITGB4 G6PC1 G6PC2 G6PC3 COL6A6 COL6A5 IFNAR1 EPO MYB EPOR KITLG IFNB1-4 IL3RA ATF6B CREB3L3 CREB3L4 CREB3L1 CREB3L2 IL2RG JAK3 CREB3 ATF4 CREB5 GYS2 FGF2 FGF3 FGF4 FGF5 FGF6 GHR FGF7 FGF8 OSMR FGF9 CSF1 F2R PDGFB FGF20 FGF23 FGF22 SGK1-1 FGF21 FN1 GNG10 CSF3R ITGA2B FGF17 PGF FGF14 THBS2 FGF19 FGF18 FGF13 HSP90AB1 FGF12 CDKN1A FGF11 FGF10 FLT1 HGF FLT3 FLT4 EIF4E1B PTEN PIK3CD PIK3CB PIK3CG LPAR2 IGF1R LPAR3 RPTOR ITGA1 LPAR4 LPAR5 CCND1 LPAR6 MYC AKT2 AKT3 MLST8 KDR JAK2 VEGFD IL6R HRAS PDGFRB PDGFRA TSC2 COL4A1 TSC1 COL4A4 COL4A3 COL4A6 COL4A5 KIT IL7R PCK1 LAMC3 SOS1 LAMC2 SOS2 MET TP53 EPHA2 COL9A1 COL1A2 CSF1R COL9A3 LAMA2 MDM2-2 LAMA1 LAMA4 LAMA3 LPAR1 EGFR LAMB3 LAMB2 LAMB4 LAMB1 NTRK1 NGFR NTRK2 INSR ITGA11 ITGB5 ITGB8 MTOR ITGA8 ITGA7 ITGA9 RHEB KRAS GRB2 COL9A2 TEK FGFR4 FGFR3 VWF FGFR2 FGFR1 IGF1 CSF3 IL7 RAC1 ITGB6 IL4R PIK3R3 PIK3R2 PIK3R1 NRAS BAD PDGFD PDGFC VEGFB CDKN1B IL4 CCND3 CCNE1 IL2RA ANGPT2 NTF4 ITGA4 ITGB3 ANGPT1 CCND2 ANGIOTENSIN II RECEPTOR TYPE 1 PATHWAY%WIKIPATHWAYS_20260510%WP5036%HOMO SAPIENS Angiotensin II receptor type 1 pathway ACE2 MAS1 TGFBR2 F12 SP1 IL11RA TGFBR1-1 RRAS IL6ST MAPK1 RAF1 SMAD2;SMAD3 MAP2K6 CCN2 SMAD4 RACK1 ACTA2 HIF1A COL1A2 NOX4 PTPN11 PDGFD COL1A1 AGTR1 IL11 TGFB1 JUND AGT TLR4 SIGNALING AND TOLERANCE%WIKIPATHWAYS_20260510%WP3851%HOMO SAPIENS TLR4 signaling and tolerance IL6 TBK1 IRAK3 IKBKE TRAF3 TAB1 TICAM1 MYD88 IRF3 IRF7 CXCL8 IRAK4 IKBKB NFKBIA TIRAP CHUK TRAF6 IKBKG NFKB1 RIPK1 IFNB1-4 TLR4 TRAM1 MAP3K7 TNF IRAK1 TAB2 INPP5D ERK PATHWAY IN HUNTINGTON 39 S DISEASE%WIKIPATHWAYS_20260510%WP3853%HOMO SAPIENS ERK pathway in Huntington 39 s disease RPS6KA5 CASP7 CREB1 EGF GRM1 BDNF EGFR ELK1 MAP2K2;MAP2K1 HRAS CASP3 NTRK2 MAPK3 HTT MAPK1 RAF1 FARNESOID X RECEPTOR PATHWAY%WIKIPATHWAYS_20260510%WP2879%HOMO SAPIENS Farnesoid X receptor pathway CYP8B1 CYP7A1 NR0B2 RXRA SULT2A1-4 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 FKBP5 PPARGC1A ABCB4 ABCB11 IRS2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 SLC10A1 BAAT NR1H4 SLCO2B1 FGF19 SLC27A5 IP6K3 NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN NOD PATHWAY%WIKIPATHWAYS_20260510%WP1433%HOMO SAPIENS Nucleotide binding oligomerization domain NOD pathway PYCARD DUOX2 IL1B CASP9 RAC1 IKBKB NLRP1 NFKBIA CHUK HSP90AA1 IKBKG AIM2 NOD1 NAIP NLRC4 CASP7 MEFV CASP8 XIAP NOD2 NLRP4 AAMP RIPK2 CARD9 CARD6 NLRP12 ACAP1 NLRP10 SUGT1 RELA PRDM1 ERBIN CASP1 NLRP3 NDUFA13 NLRP7;NLRP2 IL18 CASP5;CASP4 COPS6 7Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP4932%HOMO SAPIENS 7q11 23 copy number variation syndrome LAT2 USF1 CTNNB1 ACACB SF3B1 GRIP1 HSPA2 PKLR UBE2E3 UBE2E1 CLIP2 DNAJC30 ULK1 CDKN1C FKBP6 VPS28 FBLN2 ATPAF2-2 FBLN5 TBL2 TSG101 GTF2IRD1 ATF4 BCL7B BUD23 VPS9D1 VPS37C VPS37D VPS37A VPS37B METTL27 ATPAF1 UBIAD1 MVB12A DLD EIF4H HDAC2 CLASP2 PCNA TRIM74;TRIM73;TRIM50 TMEM270 MYO1C CLTC CLDN3 ATP5MC2 CFL1 ATP5MC3 UBE2L6 ATP5MC1 RFC5 ATP5F1A ATP5F1B BECN1 CLASP1 ATP5PB ATP5F1D ATP5PO STX1A CLDN5 EIF2AK3 RFC2 ABHD11 EIF2A CLDN1 MYC DLST HOXC8 NUP62 OGDH CHTF18 LIMK1 SNAP25 BRD4 GTF2I VAMP2 HDAC6 BTK BAZ1B GRB2 GAPDH-1 SMARCA5 DEK SQSTM1 NRG1 CLDN4 ERCC6 WNT2 ACACA FZD9 FAS RB1 PRKG1 MAPK3 HDAC3 DDX21 MYBBP1A FBN1 HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CARCINOMA PATHWAY%WIKIPATHWAYS_20260510%WP4206%HOMO SAPIENS Hereditary leiomyomatosis and renal cell carcinoma pathway LDHA KEAP1 PRKAB1 TP53 HIF1A ACACA PDK1 PRKAA1 CUL3 RPS6 PRKAG1 EGLN1 PDHB PDHA1 VEGFA ACACB NFE2L2 SLC2A1 SLC11A2 MAMMARY GLAND DEVELOPMENT EMBRYONIC DEVELOPMENT STAGE 1 OF 4%WIKIPATHWAYS_20260510%WP2813%HOMO SAPIENS Mammary gland development embryonic development stage 1 of 4 ERBB4 ITGB1 ALPL CCND1 ITGA6 MYC TERT CDH1 TNF AKT1 NRG3 TGFB1 ZEB2 CLDN4 SFRP1 ARACHIDONATE EPOXYGENASE EPOXIDE HYDROLASE%WIKIPATHWAYS_20260510%WP678%HOMO SAPIENS Arachidonate epoxygenase epoxide hydrolase COX8A CYP2C9;CYP2C19 GSTP1 EPHX2 COX5A CYP2J2-1 STATIN INHIBITION OF CHOLESTEROL PRODUCTION%WIKIPATHWAYS_20260510%WP430%HOMO SAPIENS Statin inhibition of cholesterol production LRP1 APOA5 LPL LCAT CYP7A1 APOA4 LIPC LDLR PLTP ABCG8 ABCG5 DGAT1 SOAT1 PDIA2 MTTP APOE ACSS1 ABCA1 APOB FDFT1 SQLE APOC2 APOC1 APOA2 HMGCR APOA1 SCARB1 APOC3 CETP JAK STAT SIGNALING IN THE REGULATION OF BETA CELLS%WIKIPATHWAYS_20260510%WP5358%HOMO SAPIENS JAK STAT signaling in the regulation of beta cells KRAS IL6 RPTOR SOCS2 FOXM1 AKT2 AKT3 MLST8 GHR JAK2 IL6R CDK4 HRAS AKT1 CISH PRL IFNGR1 AKT1S1 EPO IFNGR2 IFNG NRAS EPOR SOCS3 STAT5A STAT5B STAT1 PRLR CCND3 SOCS1 STAT3 MTOR CCND2 FABP4 IN OVARIAN CANCER%WIKIPATHWAYS_20260510%WP4400%HOMO SAPIENS FABP4 in ovarian cancer FABP4 SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP %WIKIPATHWAYS_20260510%WP3391%HOMO SAPIENS Senescence associated secretory phenotype SASP H3-3A ANAPC7 ANAPC4 ANAPC5 CDKN2A ANAPC1 ANAPC2 CDK6 CDK4 ANAPC10 ANAPC11 UBE2S JUN MAPK1 NFKB1 UBE2C CDK2 CDC16 UBE2E1 CCNA2-1 H2AC14 EHMT2 H2BC21 CCNA1 RPS6KA3 RPS6KA1 EHMT1 STAT3 RPS27A H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H4C1 IL6 CDC26 UBA52 H4C6 ANAPC15 FZR1 H2BC5 ANAPC16 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AB2;H2AB3;H2AB1 H2BC1 H4-16 CDKN2D H2BC15;H2BC3;H2BC11;H2BC12 CDKN2B H2AC20 CDKN2C CXCL8 H2AZ2;H2AZ1 FOS UBE2D1 IL1A H2AC4 IGFBP7 CEBPB RELA RPS6KA2 CDKN1B MAPK7 MAPK3 CDC23 UBB;UBC CDKN1A CDC27 INTRACELLULAR TRAFFICKING PROTEINS INVOLVED IN CMT NEUROPATHY%WIKIPATHWAYS_20260510%WP4856%HOMO SAPIENS Intracellular trafficking proteins involved in CMT neuropathy LRSAM1 NDRG1 RAB7A HSPB8 HSPB1 LITAF SH3TC2 RAB25 EGR2 RAB4B GDAP1 SBF2 FGD4 NEFL DNM2 MTMR2 RAB3A RAB11A RAB11B FIG4 MPZ RAB4A PMP22 RAB3B KIF1B MFN2 RABAC1 HEMATOPOIETIC STEM CELL GENE REGULATION BY GABP ALPHA BETA COMPLEX%WIKIPATHWAYS_20260510%WP3657%HOMO SAPIENS Hematopoietic stem cell gene regulation by GABP alpha beta complex GZMH;GZMB-1 FLT3 EP300 SMAD4 DNMT1 PTEN BCL2L1 DNMT3B DNMT3A FOXO3 BCL2 ZFX SMARCA4 CREBBP ETV6 ATM MCL1 GABPB1 GABPA TERF2 PAFAH1B1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260510%WP5409%HOMO SAPIENS PAFAH1B1 copy number variation DCX DYNC1H1 TUBA1A VLDLR RELN PAFAH1B1 NDEL1 NUDC PAFAH1B2 CLIP1 PAFAH1B3 GUT LIVER INDOLE METABOLISM %WIKIPATHWAYS_20260510%WP3627%HOMO SAPIENS Gut liver indole metabolism CYP2E1 METABOLISM OF DICHLOROETHYLENE BY CYP450%WIKIPATHWAYS_20260510%WP3666%HOMO SAPIENS Metabolism of dichloroethylene by CYP450 CYP2E1 GENES ASSOCIATED WITH THE DEVELOPMENT OF RHEUMATOID ARTHRITIS%WIKIPATHWAYS_20260510%WP5033%HOMO SAPIENS Genes associated with the development of rheumatoid arthritis TRAF1 ITGAV BLK HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CTLA4 CD40 CIITA IRF5 FCRL3 PTPN22 PADI4 CD244 PHF19 IL2RA STAT4 CCR6 IL6ST SLC22A4 NAD BIOSYNTHETIC PATHWAYS%WIKIPATHWAYS_20260510%WP3645%HOMO SAPIENS NAD biosynthetic pathways NAPRT TNKS SIRT4 ACMSD TDO2 IDO1 PARP4 SIRT5 NMNAT1 QPRT PARP2 SIRT1 CD38 SIRT2 SIRT3 NAMPT TNKS2 BST1 NADSYN1 PARP1 SIRT6 RAC1 PAK1 P38 MMP2 PATHWAY%WIKIPATHWAYS_20260510%WP3303%HOMO SAPIENS RAC1 PAK1 p38 MMP2 pathway MSH2 RASA1 CTNNB1 MYC HRAS ANGPT4 IKBKB NFKBIA BIRC5 CHUK PIK3CA FOXO1-1 ERBB2 MAPK1 IKBKG NOS2 NFKB1 MAPK12 MAPK11 CASP7 SOS1 TP53 GRB14-1 SRC YAP1-1 STAT5A EGFR STAT5B GRB7 STAT3 MMP2 KRAS NOS1 GRB2 TEK DOK2 NCK1 CASP9 RAC1 RS1 STMN1 AKT1 TNIP3-2 ANGPTL1 TIE1 CRK TNIP1 TNIP2 PXN PIK3R1 EIF4EBP1 NRAS PAK1 RAD51 ITGB1 BAD RELA PTPN11 FN1 MAPK9 BAX MAPK8 MAPK13 MAPK3 ANGPT2 ANGPT1 MAPK14 PTK2 CARDIAC PROGENITOR DIFFERENTIATION%WIKIPATHWAYS_20260510%WP2406%HOMO SAPIENS Cardiac progenitor differentiation SOX2 MYL2 NKX2-5 SOX1 ACTC1;ACTG2 MEF2C ZFP42 NOTCH1 KDR POU5F1;POU5F1B MESP2 PDGFRA ROR2 INS;INS-IGF2 SCN5A NODAL KIT ANPEP PAX6 NANOG;NANOGP8 TBX20 IRX4 TBX5 ISL1 IGF2 BMP1 TNNI3 LIN28A LIN28B TNNT2 SOX17 MIXL1 GATA4 FGF2 IGF1 GSK3B MYH6 NRG1 MYLK3 NOG MESP1 THY1 TBXT SIRPA;SIRPB1;SIRPG WNT3A CXCR4 NCAM1 INHBA FOXA2 BMP4 TGFB1 DKK1 MAPK14 CLEAR CELL RENAL CELL CARCINOMA PATHWAYS%WIKIPATHWAYS_20260510%WP4018%HOMO SAPIENS Clear cell renal cell carcinoma pathways FLT1 EP300 PTEN KCNJ2 RPTOR DEPTOR SETD2 GRB10 HK2 MLST8 KDR FASN CREBBP PDGFRB PDGFRA RAPGEF5 KSR1 VEGFA TSC2 MDH1 PLOD2 TSC1 PFKL SSPN ACACB ACLY AKT1S1 ENO2 ENO3 PFKP ALDOC PKLR MAP2K5 LDHA;LDHC EGFR CAMK1 SHMT1 HK3 CDH13 GPI PGM2 STAT3 TPI1 MTOR SLC2A1 ENO1 RHEB HK1 LDHA GAPDH-1 PKM ALDOB PGK1 PGM1 ALDOA PFKM SHMT2 SQSTM1 PSAT1 PHGDH PSPH AKT1 CEP290 KDM5C BHLHE41 EFCAB3 PBRM1 TOX2 PDGFB SDSL PGBD5 LDHD SDS ARNT HIF1A ACACA VHL BAP1 ENPP3 ME1 LDHB ZEB1 RETT SYNDROME%WIKIPATHWAYS_20260510%WP4312%HOMO SAPIENS Rett syndrome XAB2 HDAC1 GABBR2 SCN8A SCN2A ACTL6B SMARCA1 MECP2 GABRA3 TCF4 MEF2C SMARCA4 EIF2B2 NCOR1 CRK SRRM3 GNAO1 HDAC8 NCOR2 GRIN2A KDM5B TRRAP STXBP1 FOXG1 GPS2 CDKL5 RHOBTB2 CECR2 HIVEP2 KCNJ10 TBL1XR1 SYNGAP1 IMPDH2 SMARCA2 CHD4 SMC1A GRIN2B HDAC5 SYNE2 HAP1 HTT SHANK3 SATB2 BRAF TAF1B GABRD SCN1A PURINE METABOLISM%WIKIPATHWAYS_20260510%WP4792%HOMO SAPIENS Purine metabolism XDH ATIC ADSL ADA AMPD1 APRT DGUOK IMPDH1 ADSS2 HPRT1 ITPA PRPS1 PNP-1 COVID 19 STRUCTURAL COVERAGE MAP%WIKIPATHWAYS_20260510%WP5145%HOMO SAPIENS COVID 19 structural coverage map ACE2 UBA52 TAB1 ISG15 AQR UPF1 SLC6A19 NLRP12 NRP1 IGHMBP2 MRM2 MACROD1 MACROD2 CMTR1 MPP5 PAIP1 UPF2 GDAP2 TOMM70 PARP14 PARP9 MACROH2A2 UBB;UBC APOA1 MACROH2A1 EUKARYOTIC TRANSCRIPTION INITIATION%WIKIPATHWAYS_20260510%WP405%HOMO SAPIENS Eukaryotic transcription initiation GTF2H1 TAF7 GTF2H3 TAF6 GTF2H4 TAF12 ERCC3 POLR2A POLR2B ERCC2 TAF13 GTF2F2 MNAT1 POLR2G POLR2I POLR2C ILK POLR2J;POLR2J2;POLR2J3 POLR3B POLR3D POLR3H POLR3E POLR3K TAF5 GTF2B POLR1A POLR1B CDK7 POLR1D POLR1E GTF2A2 GTF2E1 POLR2E CCNH POLR2F GTF2H2C;GTF2H2C_2;GTF2H2 POLR2H TBP TAF9 GTF2E2 IMATINIB AND CHRONIC MYELOID LEUKEMIA%WIKIPATHWAYS_20260510%WP3640%HOMO SAPIENS Imatinib and chronic myeloid leukemia FLT1 SKP2 PIM1 CSF1R ABCB1 BCR PIM2 FOXO3 LYL1 GADD45A MYC ABCG2 CDKN1B PDGFRB PDGFRA ABL1 NOP2 GAB2 SPRED2 KIT TRANSLATION FACTORS%WIKIPATHWAYS_20260510%WP107%HOMO SAPIENS Translation factors ETF1 EIF4G3 EIF4A1 EIF4EBP2 EIF4B EIF2B5 EIF2B4 EIF4E PABPC1;PABPC3 EIF2B2 EIF5A;EIF5AL1 EIF5B EIF2AK2 EIF4EBP1 EIF2S3;EIF2S3B EIF1 EIF3C;EIF3CL EIF5 EIF1AY;EIF1AX EEF2K EIF3I EIF3J EIF3G EIF3E EIF3F EIF3D EIF2S2 EIF3A EEF2 EIF3B EIF2S1 EIF6 PAIP1 EIF2B1 EIF2AK1 GSPT2 EEF1B2-1 EIF2AK3 EIF4A2 EIF2B3 CLUH EEF1A1 EEF1G EEF1D EIF3H EIF4G1 EIF4H EEF1A2 DRUG INDUCTION OF BILE ACID PATHWAY%WIKIPATHWAYS_20260510%WP2289%HOMO SAPIENS Drug induction of bile acid pathway NR1I2 CYP7A1 VDR SULT2A1-4 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ABCB1 NR1I3 ABCB11 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC3 ABCC4 ABCC2 SLC10A1 SLC51A BAAT NR1H4 SLC51B GLIAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260510%WP2276%HOMO SAPIENS Glial cell differentiation PLP1 MBP MAG CNP TPPP GAP43 MSN CALCIUM MEDIATED T CELL APOPTOSIS INVOLVED IN INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260510%WP5142%HOMO SAPIENS Calcium mediated T cell apoptosis involved in inclusion body myositis HDAC2 MEF2D ITPRIP EP300 HDAC1 LCK NR4A1 NFATC2 CD8A ATP2A1 CD8B;CD8B2 CAPN2 CALM1 CD4 PLCG1 PPP3CB ZAP70 PPP3CA CABIN1 PPP3CC AMPLIFICATION AND EXPANSION OF ONCOGENIC PATHWAYS AS METASTATIC TRAITS%WIKIPATHWAYS_20260510%WP3678%HOMO SAPIENS Amplification and expansion of oncogenic pathways as metastatic traits CYTIP TNC WNT2 PIK3CG EPAS1 SRC TCF7 LEF1 VHL TCF7L2 NOTCH1 CXCR4 POSTN JAG1 VEGFA VCAM1 TCF7L1 ACQUIRED PARTIAL LIPODYSTROPHY BARRAQUER SIMONS SYNDROME%WIKIPATHWAYS_20260510%WP5104%HOMO SAPIENS Acquired partial lipodystrophy Barraquer Simons syndrome C3-1 LMNA RCE1 CFB CFD FNTA ICMT LMNB1 LMNB2 C5 ALLOGRAFT REJECTION%WIKIPATHWAYS_20260510%WP2328%HOMO SAPIENS Allograft rejection IL2 CXCL11 GDNF HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CXCL12 CTLA4 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E HARS1 CD28 CXCL9 IL13 PDGFRA VEGFA CXCR5 FASLG GABPA CCL19 CASP7 CD40LG CASP8 IL5 CCL21 ABCB1 LOC110384692;C4A;C4B_2;C4B HLA-DOA VIM HLA-DOB PECR AGTR1 STAT1 TNF HLA-DRA CSNK2A2 HLA-DPB1-1 C2 HLA-DPA1 C5 HLA-DQB2;HLA-DQB1 C6 C7 GZMH;GZMB-1 C9 IL1B C8B CD80 C8A CXCL8 IL21 BHMT2 IL22 HLA-DMB CASP9 PRKCZ CASP3 LRRK2 C1QB CXCL13 IL12B IL12A FOXP3 IFNG IL1A HLA-DMA CD40 CD55 C3-1 IL4 FAS IL2RA C1QC PRF1 IL10 TGFB1 CD86 IL17A COL5A1 PHOTODYNAMIC THERAPY INDUCED UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260510%WP3613%HOMO SAPIENS Photodynamic therapy induced unfolded protein response DNAJB9 EDEM1-1 DNAJC3-1 ERP27 EIF2A DDIT3 NARS1 ASNS WARS1 DNAJB11 NFE2L2 ATF6 BBC3 ERN1 CALR-1 BCL2L11 PDIA6 XBP1 PPP1R15A ATF3 UBE2E1 TRIB3 ATF4 HSP90B1 EIF2AK3 HSPA5 ENVELOPE PROTEINS AND THEIR POTENTIAL ROLES IN EDMD PHYSIOPATHOLOGY%WIKIPATHWAYS_20260510%WP4535%HOMO SAPIENS Envelope proteins and their potential roles in EDMD physiopathology ADCY9 KRAS GRB2 MAP3K9 SYNE4 KIF5B EMD SYNE3 BANF1 SUN1 PLEC SRF ADCY4 ADCY3 ADCY2 HRAS ADCY1 ADCY8 CFL1 ADCY7 ADCY6 ADCY5 MAPK1 LBR SMAD2;SMAD3 RHOA TGFB2 NRAS CCN2 SMAD4 SOS1 TGFB3 SOS2 TMEM43 TMPO LEMD3 MAP2K2;MAP2K1 ADCY10 MAPK3 SYNE2 TGFB1 SYNE1 WWTR1 MONOAMINE TRANSPORT AND REGULATION%WIKIPATHWAYS_20260510%WP727%HOMO SAPIENS Monoamine transport and regulation NOS1 CDC25C ADORA2A TGFB1I1 IL1B HRH3 NECTIN2 TSC2 TNFRSF11B SCAMP2 SLC6A1 UNC13B ACHE SLC5A7 TPH2 IL1R1 TDO2 DBH AMPH TH PPP2CB;PPP2CA FBXO32 STX1A SLC6A2 SYN1 RBL2 TNF SLC6A4 SLC6A3 ITGB3 MAPK14 AGT IL2 SIGNALING%WIKIPATHWAYS_20260510%WP49%HOMO SAPIENS IL2 signaling IL2 GRB2 IL2RB FYN SHC1-1 CRKL NMI PTK2B HRAS AKT1 CISH MAPK1 RAF1 CBL PIK3R1 SOS1 LCK FOXO3 SOCS3 JAK1 PTPN11 IL2RG STAT5A STAT5B JAK3 SYK STAT1 MAP2K2;MAP2K1 RPS6 RPS6KB1 RPS6KB2 IL2RA MAPK3 MAPT GAB2 STAT3 IL11 SIGNALING%WIKIPATHWAYS_20260510%WP2332%HOMO SAPIENS IL11 signaling ITGA2 GRB2 PTPA ICAM1 FYN BCL2 FES JAK2 PDPK1 IL11RA HRAS IKBKB YES1 AKT1 PIAS1 BIRC5 PIAS3 CHUK IL6ST MAPK1 RAF1 TYK2 PIK3R2 IBSP PIK3R1 CREB1 ATF1 SRC SOCS3 RELA JAK1 PTPN11 STAT1 MAP2K2;MAP2K1 RPS6 RPS6KB1 IL11 RPS6KA1 MAPK3 RUNX2 TGFB1 STAT3 INTRAFLAGELLAR TRANSPORT PROTEINS BINDING TO DYNEIN%WIKIPATHWAYS_20260510%WP4532%HOMO SAPIENS Intraflagellar transport proteins binding to dynein IFT122 WDR35 DYNC1I1 IFT43 DYNC2H1 DYNC1LI1 DYNC1LI2 IFT80 IFT46 DYNLT2B DYNC1I2 IFT27 IFT81 DYNLRB2 HSPB11 DYNLRB1 DYNC1H1 WDR19 DYNC2LI1 DYNC2I2 DYNC2I1 DYNLT1 IFT140 IFT22 REGUCALCIN IN PROXIMAL TUBULE EPITHELIAL KIDNEY CELLS%WIKIPATHWAYS_20260510%WP4838%HOMO SAPIENS Regucalcin in proximal tubule epithelial kidney cells CALCA PTH NOS1 MCU CRYZL2P-SEC16B;SEC16B RGN CASP9 TGFBR1-1 CASP3 AKT1 FFAR3;GPR42 MAP3K5 PIK3CA MAPK1 APAF1 RAF1 SMAD2;SMAD3 TNFSF11 CASP8 SMAD4 TRPV5 PDE1B PPP3R1 ACTA2 TNFRSF1A BAK1 G3BP1 BAX TGFB1 MTOR BRAF MSMP EXPRESSION REGULATION IN CANCER CELLS AND ITS PRO ANGIOGENIC ROLE IN OVARIAN TUMORS%WIKIPATHWAYS_20260510%WP4397%HOMO SAPIENS MSMP expression regulation in cancer cells and its pro angiogenic role in ovarian tumors MSMP CTCF CCR2 NEUROINFLAMMATION%WIKIPATHWAYS_20260510%WP4919%HOMO SAPIENS Neuroinflammation MAPK8 ASCC1 NFKBIA TLR4 JUN CHUK RELA MTOR NOS2 MAPK14 FOS INHIBITION OF EXOSOME BIOGENESIS AND SECRETION BY MANUMYCIN A IN CRPC CELLS%WIKIPATHWAYS_20260510%WP4301%HOMO SAPIENS Inhibition of exosome biogenesis and secretion by manumycin A in CRPC cells KRAS NRAS HGS HNRNPH1 RAB5A RRAS2 ARAF RAB27A MRAS PDCD6IP HRAS RAB5C MAPK3 RRAS RAB5B MAPK1 BRAF RAF1 MAJOR RECEPTORS TARGETED BY EPINEPHRINE AND NOREPINEPHRINE%WIKIPATHWAYS_20260510%WP4589%HOMO SAPIENS Major receptors targeted by epinephrine and norepinephrine ADCY9 ADRB1 ADCY4 ADRB2 ADCY3 ADRA2C ADCY2 ADCY1 ADRA2B ADCY10 ADRA1D ADCY8 ADRA2A ADCY7 ADCY6 ADCY5 2Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260510%WP5221%HOMO SAPIENS 2q11 2 copy number variation syndrome DUSP2 ANKRD39 LMAN2L NCAPH PARL CIAO2B CIAO1 FAM178B ITPRIPL1 ERBB2 TMEM127 MAPK1 COX11 CNNM3 CNNM4 ANKRD23 SNRNP200 FER1L5 STARD7 SEMA4C RHOA ASTL NEURL3 CIAO2A KANSL3 PLXNB2 ZP2 MMS19 COL2A1 ADRA2B MAPK3 GLUCOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260510%WP5280%HOMO SAPIENS Glucocorticoid biosynthesis CYP21A2 SRD5A2 SRD5A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP11B1;CYP11B2 CBR1-1 HSD11B1 HSD11B2 AKR1D1 ANTIVIRAL AND ANTI INFLAMMATORY EFFECTS OF NRF2 ON SARS COV 2 PATHWAY%WIKIPATHWAYS_20260510%WP5113%HOMO SAPIENS Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway ACE2 HMOX1 IL6 KEAP1 RXRA IRF3 NOX1 IL1B CXCL8 MMP1 GUCY1B1 IKBKB NFKBIA CHUK NFE2L2 IKBKG NFKB1 IL12A GCLC GCLM NQO1 MMP3 RELA GSTA3;GSTA5;GSTA1;GSTA2 CCL13;CCL2 TNF PRKG2 GUCY1A2 GUCY1A1 TMPRSS2 SLC7A11 PHASE I BIOTRANSFORMATIONS NON P450%WIKIPATHWAYS_20260510%WP136%HOMO SAPIENS Phase I biotransformations non P450 PON2 LIPA PON1 ESD CES5A CES2 CES1 PON3 NONALCOHOLIC FATTY LIVER DISEASE%WIKIPATHWAYS_20260510%WP4396%HOMO SAPIENS Nonalcoholic fatty liver disease CYP2E1 DDIT3 PRKAA1 IKBKB JUN ADIPOR2 PIK3CA TRAF2 NFKB1 PRKAB2 PRKAB1 XBP1 NDUFA12 PKLR COX6A2 COX7A2L-1 NDUFB3 NDUFA10 PRKAG1 PRKAG2 PRKAG3 ATF4 NDUFB9 NDUFA11 COX7B NDUFC1 NDUFS8 COX4I1 NDUFS7 UQCRB COX7A2 NDUFS6 NDUFS4 NDUFS3 COX5B COX6A1 NDUFS2 UQCR11 COX7C NDUFS1 UQCR10 NDUFB8 COX5A UQCRQ NDUFB7 NDUFB10 UQCRC1 NDUFB6 CYC1 COX8A NDUFB5 UQCRC2 NDUFB4 SREBF1 NDUFB2 NDUFA4 NDUFA4L2 UQCRFS1 COX6C COX6B1 NDUFB1 NDUFC2;NDUFC2-KCTD14 NDUFV3 NDUFV2 NDUFB11 NDUFV1 NDUFA9 NDUFA8 SDHC SDHD NDUFA7 IL1A NDUFA6 TNFRSF1A NDUFA5 NDUFA3 NDUFAB1 NDUFS5-1 ITCH NDUFA13 EIF2AK3 PIK3CD PIK3CB CEBPA AKT2 AKT3 IRS2 IRS1 IL6R MAP3K11 NR1H4 INS;INS-IGF2 CDC42 SDHA FASLG ADIPOQ LEPR BBC3 CASP7 LEP CASP8 BCL2L11 BID COX6B2 COX7B2 GSK3A COX4I2 MLX COX8C MLXIP TNF INSR NR1H3 SDHB IL6 RXRA PPARA IL1B GSK3B CXCL8 RAC1 CASP3 AKT1 MAP3K5 PIK3R3 PIK3R2 ERN1 PIK3R1 SMAD7 CYCS-1 PRKAA2 BAK1 SOCS3 RELA CCL13;CCL2 EIF2S1 MAPK9 BAX MAPK8 FAS TGFB1 VCAM1 ADIPOR1 GPCRS CLASS A RHODOPSIN LIKE%WIKIPATHWAYS_20260510%WP455%HOMO SAPIENS GPCRs class A rhodopsin like P2RY1 HCRTR2 HCRTR1 ADORA2A MTNR1B CCR10 CCR1 XCR1 CCR9 CCR8 CCR7 CCR6 CCR4 CCR2 CXCR1 CXCR5 CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 OPN1SW OPN1MW3;OPN1MW2;OPN1MW;OPN1LW RHO GPR85 ADRB1 ACKR3-2 ADRB2 HTR2A HTR1E HTR1F HTR1D HTR1A FFAR3;GPR42 FFAR2 HTR1B GRPR GPR35 CCRL2 OR2B6;OR2B2-1 P2RY12 OR1F1 OR2H1-1 P2RY10 P2RY14 ADRA1D OR1E1;OR1E2 ADRA1B ADRA1A OR10A5 OR3A1 OR2A7;LOC107987545;OR2A4 NTSR1 GPR17 PTGDR2 ADRB3 P2RY13 P2RY11 OR2F1-2 GPR18 GPR87 CCKBR SSTR1 ACKR4 GPR161 C3AR1 CMKLR1 CCR5 F2RL2 GPR15 C5AR2 GPR32 MAS1 FSHR CNR1 AVPR1B CX3CR1 AVPR2 HTR2B HTR4 HRH1 HTR6 HTR7 HRH2 DRD5 ADRA2C HTR5A ADRA2B ADRA2A CCR3 NPY4R2;NPY4R BRS3 CCKAR NPY5R MC1R OPRM1 AVPR1A SSTR3 SSTR4 TRHR SSTR5 OPRD1 MC2R GALR3 GALR2 GALR1 GPER1 NTSR2 MC5R CXCR2 EDNRA EDNRB AGTR1 FFAR1 AGTR2 NMBR GPR37 F2R GPR68 FPR1 GPR83 NPFFR1 OPRK1 BDKRB2 BDKRB1 LPAR4 LPAR5 LPAR6 HRH3 F2RL3 GHSR LHCGR PTGER4 PTGFR F2RL1 PTGIR NPFFR2 PTGER1 RRH PTGER2 GPR174 PTGER3 GPR173 PTAFR GPR171 GPR37L1 GPR50 OR7A10;OR7A17-11 MTNR1A OR2AG1;OR2AG2 CNR2 OR1I1 TBXA2R FPR2 NPBWR1 NPBWR2 OR6B1 LTB4R GPR12 CYSLTR1 HCAR2;HCAR3 CYSLTR2 OR6A2 GPR19 GPR27 GPR25 GPR21 GPR22 GPR20 OR10H1;OR10H5;OR10H2 GPR39 GPR34 OR1A1-1 OR2S2-1 OR3A2 GPR45 CHML GPR52 GPR1 OR8D2-1 GPR4 GPR3 GPR6 OR1C1 GPR65 GPR63 GPR75 OR2D2 NPY1R OR2T1 APLNR OR5V1-2 OR2C1 DRD4 SUCNR1 OR5I1 MCHR1 OR1Q1 HCAR1 OR2B3 SSTR2 OR2J1;OR2J2;OR2J3-2 NMUR2 P2RY6 NMUR1 P2RY4 MC3R OR14J1 ADORA2B MLNR P2RY2 ADORA3 OR7C1;OR7C2-9 PRLHR OR2H2 OR10A4 OR8B8 OR2W1 OR12D3 OR1D2 OR10J1-2 ACKR2 OR11A1 OPN4 MC4R OPN3 CXCR4 OXTR OPRL1 NPY2R CXCR3 ADORA1 DRD1 DRD2 DRD3 PTGDR}