FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway Brca1 Usp1 Fancd2 Rad17 Stt3a Ube2t Wdr48 Rmi1 Topbp1 Fancl Btrc Atrip Fanca Fancf Fancc Fancb Rfc5 Palb2 Fance RGD1306926 RGD1564719 Rfc2 Rfc4 Rfc3 Mre11a Nbn Fbxw11 H2afx Brca2 Blm Atr Hus1 Atm Rad50 Rad1 Hes1 Fan1 Rpa1 Rpa2 IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks Hnf4a Hadh Cpt1c Ttr Nkx2-1 Cpt1b Kcnj11 Foxa1 Igfbp1 Cebpa Cpt1a Bdh1 Hmgcs1 Dlk1 Abcc8 Tfrc Tat Aldob Sp1 Pck1 Ucp2 Afp Acadm Acadvl F2 Alb Akt1 Foxa2 Foxa3 Pklr Nf1 Creb1 G6pc Slc2a2 Hnf1a Ins2 IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events Cish Sdcbp Pik3r1 Stat5a Lyn Grb2 Ptpn11 Il5ra Csf2rb Stat5b Il5 Pim1 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events Mdk Itga5 F2 Cxcl12 Rac1 Sdc4 Tfpi Prkca Lama1 Plg Fn1 Fgf6 Fgf2 Nudt16l1 Ptk2 Fgfr1 Mmp9 Ccl5 Adam12 Sdcbp Gipc1 Rhoa Cxcr4 Itgb1 Actn1 Dnm2 Prkcd BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway Mapk1 Rac1 Mapk8 Pten Csnk2a1 Raf1 Fos Dok1 Nfkb1 Jun Bcl10 Chuk Ppp3ca Shc1 Ppp3cb Map3k7 Ptprc Blnk Fcgr2b Rela Vav2 Bcl2a1 Cd22 Ikbkb Mapk14 Ets1 Syk Csk Camk2g Cd19 Cd79al Akt1 Cd79b Map2k1 Pik3r1 Pdpk1 Cd72 Rasa1 Ptpn6 Hras Elk1 Dapp1 Lyn LOC100912399 Grb2 Traf6 Map3k1 Nfkbia Sos1 Nfkbib Map4k1 AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling Klhl9 Cul3 Bub1 Stmn1 Klhl13 Sept1 Ncapd2 Ndc80 Incenp Kif23 Racgap1 Smc2 Cenpa Smc4 Sgol1 Psma3 Pebp1 Ncapg Ppp1cc Mylk Rasa1 Kif20a Des Vim Cbx5 Rhoa Aurkb Aurka Tacc1 Cdca8 Kif2c Npm1 Nsun2 N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events Pip5k1c Ctnnd1 Plcg1 Ptpn1 Gsn Cdh2 Gja1 Rac1 Mapk8 Fgfr1 Kif5b Pik3r1 Gap43 Fer Rock1 Jup Mapre1 Dagla Rhoa Ptpn11 Cttn Cnr1 Dctn1 Lrp5 Camk2g Ctnna1 Daglb REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase Hdac2 Hdac1 Mre11a Nbn Mapk1 Fos Nfkb1 Jun Xrcc5 Ywhae Esr1 Xrcc6 Sp1 LOC100909750 E2f1 Hnrnpc Ccnd1 Tnks Akt1 Acd Ifng Parp2 Tinf2 LOC100911576 Blm Sin3a Max Hus1 Ube3a Atm Mxd1 Rad50 Znfx1 Rad1 Myc Sap18 Abl1 Nr2f2 Pinx1 Tert Smg5 Smg6 Rps6kb1 Rbbp7 Tgfb1 RGD1561590 Wt1 Hdac1l Irf1 Egfr Cdkn1b Pot1 Terf2ip Terf2 LOC103692716 Smad3 Terf1 Mtor Il2 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma Plcg1 Ywhae Ccnd1 Akt1 Camk4 Creb1 Src Kras Sfn Camk2a Gab1 Trpv1 Ntrk1 Egr1 Ywhaz Shc1 Ngf Bad Foxo3 Ywhab Pdpk1 Pik3r1 Trpc3 Stat5a Gsk3b Nras Hras Ywhag Ywhah Grb2 Sos1 Prkcd IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events Pias3 Lbp Jak1 Junb Bcl2l1 Map2k6 Akt1 Pias1 Il6 Timp1 Mapk11 Map2k4 Rac1 Gab2 Crp A2m Fgg Vav1 Fos Mitf Myc Hsp90b1 Jun Ptpre Socs3 Gab1 Il6st Lmo4 Hck Stat3 Stat1 Foxo1 Pik3r1 Irf1 Grb2 Mapk14 Ptpn11 Sos1 Prkcd MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway Btrc Rragc Rraga Rragd Eif4b Fbxw11 Tsc2 Mapk1 Mlst8 Tsc1 Kras Rps6ka1 Sfn Prkca LOC100910121 Raf1 Prr5 Rrn3 Map2k2 Pld2 Rptor Pld1 Bnip3 Ddit4 Yy1 Ywhaz RragB Pml Atg13 Eef2 Ywhab Ppargc1a Rb1cc1 Mapkap1 Nras Sgk1 Ywhag Irs1 Ywhah Cdk2 Ikbkb Ulk1 Poldip3 Ulk2 Eef2k Eif4a1 Cycs Pdcd4 Akt1s1 Ywhae Srebf1 Akt1 Ccne1 Eif4ebp1 Rictor Rps6kb1 Map2k1 Pdpk1 Hras Mtor ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes Ywhae Bcl2l1 Camk4 Nfatc2 Bcl2 Mapk8 Cabin1 Csnk2a1 Sfn Fkbp8 Prkca Chp1 Prkaca Fkbp1a Nfatc3 Akap5 Xpo1 Mef2d Prkcz Crebbp Ywhaz Kpna2 Bad Casp3 Prkch Ywhab Prkcb Gsk3b Ywhag Ywhah Csnk1a1 Rcan2 Mapk14 LOC100912399 Mapk9 Prkcq Map3k1 Kpnb1 Nr4a1 Prkcd Map3k8 Pim1 Ran SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family Arrb2 Dhh Shh Lrpap1 Ptch1 Cdon Gli2 Pik3r1 Boc Adrbk1 Ihh Smo Lrp2 Akt1 Tgfb2 Hhip SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events LOC102550316 Aph1b Src Mc4r Ncan Fgfr4 Fgf19 Psenen Fgfr3 Pomc Fyn Ncstn Ptn Psen1 Agrp LOC100911293 Fgf23 Egfr Sdc3 Cttn ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway Arrb2 Src Pik3r1 Rela Lck Nfkb1 Ikbkb Mapk14 Btrc Syk Nfkbia ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway Rac1 Cyth2 Ap2a1 Pld2 Gosr2 Ap2m1 Gga3 Clta Kdelr1 Gbf1 Asap1 Cd4 Uso1 Cltb Arfip2 Arfgap1 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events Ednra Egfr Hras Grb2 Edn1 Sos1 Shc1 Mtor ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway Cdc6 Smarcal1 Mcm2 Fancd2 Rad17 Mdm2 Mcm7 Stt3a Ccna2 Cep164 LOC100911267 Cdc25a Topbp1 Plk1 Timeless Btrc Rad51 Atrip Cdc25c Rfc5 Rfc2 Rfc4 Rfc3 Nbn Fbxw11 Brca2 Atr Hus1 Rad1 Rpa1 Rpa2 Ywhaz Ywhab Cdk2 Ppp2ca Clspn Ppp2r1a FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks Foxa1 Foxa2 Foxa3 S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway Gnao1 Mapk1 Gnai3 Rac1 Src Gna15 Gna14 Gna13 Gna12 Gna11 Gnaq LOC100911280 Vegfa Flt1 S1pr3 Gnai2 Pdgfb Gnai1 Pdgfrb Gnaz Akt3 Rhoa Cxcr4 Akt1 SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling Jak1 Il6 Gnai3 Kras Raf1 Map2k2 Gab1 Vegfa Ntrk1 Ngf Shc1 Nras Irs1 Rhoa Lck Tek Ntf4 Ntf3 Sdc2 Il2rg Pdgfb Gnai1 Pdgfrb Ifng Gab2 Prkaca Il6st Lmo4 Stat1 Arhgap35 Nos3 Map2k1 Ifngr1 Pik3r1 Bdnf Jak3 Angpt1 Egfr Hras Il2ra Igf1r Frs2 Frs3 Grb2 Ntrk3 Ptpn11 Ntrk2 Sos1 Il2 EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling Epha1 Epha2 Epha3 Pik3r6 Epha8 LOC100912512 Lck Blk LOC100911248 Cdk5 Cbl Plcg1 Arhgef15 Efna1 Yes1 Vav3 Crk Fyn Crkl Epha4 Ngef Epha7 Src Hck Fgr Vav2 Rock1 Efna2 Pik3cg Lyn Rhoa IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K Lck Il2rg Jak1 E2f1 Bcl2l1 Akt1 Eif3a Bcl2 Rac1 Smpd1 Gab2 Sgms1 Ugcg LOC100911372 Nfkb1 Myc Rps6 Tert Prkcz Shc1 Rps6kb1 Foxo3 Pik3r1 Jak3 Rela Il2ra Grb2 Ptpn11 LOC103692716 Sos1 Mtor Il2 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway Map3k3 Rac1 Txn1 Map3k6 Traf2 Atm Map3k4 Gadd45g Taok3 Tab2 Gadd45a Taok1 Gadd45b Map3k10 Map3k7 Mapk14 LOC100912399 Traf6 Map2k6 Map3k1 Mapk11 VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals Cd2ap Mapk1 Hif1a Nrp1 Nck1 Prkca Prkaca Shc2 Pgf LOC100911280 Vegfa Cbl Flt1 Plcg1 Nrp2 Nos3 Pdpk1 Pik3r1 Prkcb Rasa1 Ptpn11 LOC103692716 Akt1 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events Gab2 Hdac1 Prkaca Ywhaz Shc1 Cish Id1 Pik3r1 Srp9 Stat5a Hdac1l Ywhag Grb2 Ptpn11 Bcl2l1 Prkacb Csf2rb Osm Stat5b Cnksr1 Il3ra Pim1 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway Lrpap1 LOC100911248 Cdk5 Cbl Crkl Fyn Akt1 Mapk8 Cdk5r1 Itga3 Dab1 Rap1a Lrp8 Reln Pik3r1 Gsk3b Nck2 Map2k7 Vldlr Map1b Itgb1 Pafah1b1 Arhgef2 Grin2b Map3k11 ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events Pip5k1c Ctnnd1 Exoc5 Itga7 Itga6 Exoc3 Rala Itga5 Scamp2 Acap1 Tshr Nme1 Cltc LOC100360745 Exoc7 Itga3 Klc1 Agtr1a Ins2 Itga4 Itga11 Pld2 Arf6 Exoc2 Pld1 Spag9 Cdh1 Itga10 Itga8 Exoc6 Bin1 Itgb1 Adrb2 Dnm2 Vamp3 Slc2a4 Ctnna1 Mapk8ip3 CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway Nfatc2 Pou2f1 Ptgs2 Batf3 Cabin1 Cd40lg Chp1 Prkaca Fos Fkbp1a Nfatc3 Faslg Jun Akap5 Fosl1 Il4 Csf2 Il2ra Junb Rcan2 Ifng Il2 INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions Itga3 Itga4 Itga11 Itga10 Itga8 Itgax Itgb7 Itga7 Itga6 Itgb8 Itga2b Itgb4 Itga5 Itgb6 Itgal Itgb2 Itgb1 Itgam RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling Mapk8 Mapk14 Mapk9 Gnal Gnb1 Mapk11 Crh VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium Map2k4 Mapk1 Creb1 Rps6ka1 Vegfc Figf Itga4 Fn1 Flt4 Col1a2 Col1a1 Shc1 Crk Pik3r1 Itga5 Grb2 Mapk14 Itgb1 Akt1 Sos1 Mapk11 GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network Furin Mapk8 Shh Ptch1 Mapk9 Fgf7 Bmp4 GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events Prkacb Osm Mapk1 Gab2 Kras Raf1 Prkaca Fos Map2k2 Stat3 Ywhaz Stat1 Shc1 Cish Map2k1 Pik3r1 Ccl12 Csf2 Stat5a Irf8 Nras Hras Ikbkb Lyn Grb2 Ptpn11 Syk Csf2rb Sos1 Stat5b Pim1 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events Sdc4 Sdc3 Sdc2 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway Crk Iqgap1 Plcb2 Brk1 Abi1 Map2k6 Cybb Abi2 Cyba Baiap2 Noxa1 Limk1 Rac1 Mapk8 Cfl1 Bcar1 Atf2 Iqgap3 Actr3 Actr2 Arhgdia Jun Nckap1 Noxo1 Arpc3 Cdh1 Pip5k1b Pak2 Arhgap5 Pak1 Arpc4 Arpc5 Wasf1 Arpc2 Arpc1b Ncf2 Ncf1 Mapk14 Ctnna1 Pip5k1c Map2k4 Racgap1 Stat3 Stat5a LOC100912399 Map2k7 Mapk9 Map3k1 Map3k11 EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling Epha2 Rac1 Src Bcar1 Cbl Ptk2 Efna1 Vav3 Shc1 Pak1 Arhgap35 Pik3r1 Vav2 Grb2 Rhoa Tiam1 Acp1 ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events Rac1 Src Bcar1 Vegfc Figf Fn1 Spp1 Adam15 Vegfa Tgm2 F13a1 Pxn Adam12 Paox Adam2 Kcnj15 Vcam1 Adam8 Csf2 LOC497963 Sat1 Itgb1 NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events Nck1 Plcg1 Yes1 Fyn Unc5b Unc5c LOC100909609 Ntn1 Dcc Pitpna Myo10 Trio Dock1 Dapk1 Mapk1 Src Rac1 Bcar1 Map2k2 Camk2a Ptk2 Pak1 Map2k1 Pik3r1 Rhoa Map1b CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway Erc1 Prkca Ripk2 Atm Cyld Birc2 Nfkb1 Ube2d3 Bcl10 Xpo1 Tnfrsf1a Nod2 Btrc Chuk Rela Ikbkb Traf6 Nfkbia Ran VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression Brca1 Tjp2 Hdac1 Nfyc Nfyb Nfya Ndrg1 Ndrg2 Tbp Ppp2r4 Cdkn1a Zbtb17 Tmeff2 Lgals1 Cflar Dkk1 Slc11a1 Aldh9a1 Dnmt3a Smad2 Itga6 Wnt5a Fth1 Id2 Clu Ddit3 Gfi1 Hdac3 Tsc2 Gadd45a Ccl5 Foxo3 Itgb1 Cebpa Pdgfrb Sp1 Itgb4 Ccnd1 Bcl2 Creb1 Max Myc Col1a2 Rbl1 Dntt Spi1 Tmem126a Hdac1l Irf8 Cdkn2b Erbb2 Sfrp1 Cdkn1b Mxd4 Hmgcs2 Smad3 Sfxn3 Gtf2h2 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling Plcg1 Gnai2 Gnai1 Gnaz Plcb2 Akt1 Gnb1 Pelp1 Mapk1 Gnao1 Creb1 Gnai3 Src Rac1 Plcb3 Shbg Plcb1 Raf1 Fos Ar Gnrh1 Map2k2 Ptk2 Map2k1 Pik3r1 Hras FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway Birc2 Faslg Cflar Mapk10 Bid Casp8 Pik3cb Rfc1 Ezr Map2k6 Akt1 Ripk1 Fas Birc3 Fadd Mapk11 Src Mapk8 Smpd1 Cltc Chuk Casp3 Pdpk1 Pik3r1 Ikbkb Mapk14 LOC100912399 Map2k7 Mapk9 Map3k1 Syk ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling Lck Blk Ptk2b Uchl1 Grk5 Snca Yes1 Fyn Plcb2 Src Csnk2a1 Fkbp1a Pld2 Pld1 Hck Bad Klk6 Tor1a Slc6a3 Th Park7 Ube2l3 Fgr Maob Lyn Syk Prkcd P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network Tp63 DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining Dclre1c Polm Prokr1 Nhej1 Aptx Pnkp Poll Aplf Prkdc Lig4 Xrcc4 Xrcc5 Dntt Xrcc6 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 Myof Sh2d2a Cdh5 Ptpn2 Camkk2 Hsp90ab1 Vcl Akap1 Vtn Cbl Fes Grb10 Mapkapk2 Ptprj Iqgap1 Map2k6 Fbxw11 Mapk11 Mapk1 Src Prkca Raf1 Map2k2 LOC100911280 Gab1 Vegfa Flt1 Ptk2 Pak2 Rock1 Rhoa Mapk14 Dnm2 Prkcd Ctnna1 Nck1 Ptk2b Plcg1 Fyn Akt1 Prkaca Pxn Map2k1 Nos3 Pik3r1 Pdpk1 Prkcb Ptpn6 Nck2 Grb2 Ptpn11 LOC103692716 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III Hdac4 Fhl2 Sirt2 Sirt3 Cdkn1a Mef2d Crebbp Foxo1 Foxo3 Ppargc1a Xrcc6 Tubb2a Foxo4 Myod1 Acss2 LOC100909443 Tp53 Bax Hoxa11 Acss1 ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events Thbs2 Amica1 Prkar1b Adam28 Ptk2b Igsf8 Cd81 Git1 Ptpra Tln1 Crk Cd14 Mdk LOC100909609 Abi1 Dock1 Prkacb Src Rac1 Bcar1 Prkaca Itga4 Fn1 Spp1 Arf6 Ptk2 Ywhaz Pxn Vcam1 Itgb1 P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling Rtn4r Apaf1 Zfp110 Xiap Diablo Rhoc Rhob Sort1 Rac1 Mapk8 Adam17 Smpd2 Plg LOC100912195 Ngfrap1 Arhgdia Ntrk1 Chuk Shc1 Ngf Bad Casp6 Casp9 Rtn4 Ndn Mmp7 Ngfr Myd88 Prdm4 App Ikbkb Rhoa Sqstm1 Mag Bcl2l11 Prkci Maged1 Cycs Omg Mageh1 Aph1b Ripk2 Birc2 Ntf4 Psenen Ntf3 Mapk10 Ywhae Ncstn Psen1 LOC100911293 E2f1 Akt1 Prkacb Birc3 Prkcz Casp3 Furin Pik3r1 Bdnf Mapk9 Traf6 Tp53 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network Igfbp4 Rspo1 Ror2 Wnt7b Fzd1 Wnt7a Atp6ap2 Kremen2 Wnt3 Wnt1 Fzd6 Fzd4 Wnt3a Dkk1 Fzd5 Fzd2 Wif1 Wnt5a Ryk Cthrc1 Lrp6 Fzd9 Lrp5 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway Rit1 Rit2 Rap1b Map3k2 Srf Cdk5 Mapkapk2 Ehd4 Map2k5 Ntf3 Mef2c Rps6ka5 Map2k6 Mapk1 Creb1 Kras Cdk5r1 Rps6ka1 Raf1 Fos Rap1a Trpv1 Egr1 Map2k1 Nras Hras Elk1 Mapk14 Prkcd SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase Nck1 Grb10 Crk Mapk1 Creb1 Rac1 Src Mapk8 Bcar1 Prkca Prkaca Rap1a Dok1 Jun Gab1 Ptk2 Dok4 Irs2 Shc1 Ret Pxn Grb7 Pdlim7 Gdnf Dok6 Pik3r1 Shank3 Rasa1 Irs1 Hras Frs2 Rhoa Grb2 Ptpn11 Sos1 ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway Mapk1 Kalrn Nme1 Rac1 Rab11a Pld2 Arf6 Rhoa Pld1 Tiam1 EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin Rab3gap2 Unc13b Vamp2 Syt1 Chrna1 Stx1a Stxbp1 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway Ptprm Cldn1 Rac1 Src Rap1b Rap1a Pip5k1c Ptk2 Cdh1 Tln1 Crk Pdgfb Pik3r1 Pdgfrb Vav2 Iqgap1 Pvrl1 F11r Pvrl3 Ctnna1 Farp2 Pvrl2 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction Epha2 Nck1 Vcl Pip5k1c Ctnnd1 Git1 Efna1 Diaph1 Mgat3 Vasp Lima1 Exoc3 Stx4 Aqp3 Zyx Enah Myo6 Hgf Lpp Kifc3 Abi1 Arf6 Nckap1 Cdh1 Rock1 Egfr Igf1r Rhoa Actn1 Ctnna1 Pvrl2 IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway LOC100911248 Grb10 Ptpn1 Crk Crkl Ywhae Akt1 Prkd1 Bcar1 Raf1 Ptk2 Prkcz Ywhaz Irs2 Pxn Shc1 Bad Rps6kb1 Pdpk1 Pik3r1 Hras Irs1 Igf1r Nck2 Grb2 Ptpn11 Sos1 Prkcd SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) Ptpn2 LOC100911248 Cbl Ptprj Crk Crkl Hgf Mapk1 Mapk8 Rac1 Src Mlst8 Bcar1 Raf1 Map2k2 Jun Gab1 Rptor Arf6 Ptk2 Cdh1 Rin2 Egr1 Pak2 Shc1 Sh3kbp1 Pard6a Pak1 Bad F2rl2 Pak4 Sh3gl2 Snai1 Ranbp10 Muc20 Arhgef4 Apc Akt2 Rhoa Ets1 Prkci Ctnna1 Akt1s1 Rap1b Nck1 Plcg1 Ptpn1 Akt1 Eif4ebp1 Map2k4 Gab2 Rap1a Prkcz Pxn Map2k1 Pik3r1 Pdpk1 Hras Nck2 Grb2 LOC100912399 Ptpn11 Map3k1 Kpnb1 Sos1 Mtor ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway Brca1 Fancd2 Rad17 Mdm2 Trim28 Fam175a Rbbp8 Cdc25a Chek2 Kat5 Ube2n Uimc1 Smc3 Smc1a Cdc25c Ctbp1 Tp53bp1 Bid LOC100909750 Mre11a Nbn H2afx Blm Dclre1c Atm Rad50 Abl1 Xrcc4 Ywhab Terf2 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events Crk Prkd1 Gnao1 Src Gnai3 Rac1 Gna15 Gna14 Bcar1 Gna13 Gna12 Fos Gna11 Nfkb1 Gnaq Jun Pld2 Gab1 Ptk2 Mmp9 Gsk3b Rela Rhoa Tiam1 Prkcd Slc9a3r2 Ptk2b Lpar3 Lpar2 Plcg1 Lpar1 Gnai2 Adcy7 Adcy8 Gnai1 Adcy6 Mmp2 Gnaz Adcy4 Adcy5 Lpar4 Adcy3 Pik3cb Akt1 Gnb1 Hbegf Plcb3 Pxn Casp3 Pik3r1 Egfr Hras Lyn Nfkbia TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells Lck Cbl Plcg1 Fyn Akt1 Cd86 Kras Orai1 Prkca Vav1 Rap1a Cd28 Bcl10 Rassf5 B2m Lat Chuk Cd80 Trpv6 Shc1 Cd8b Cd8a Cd3d Lcp2 Ptprc Cd3e Pdpk1 Rasgrp2 Prkcb Stim1 Map3k14 Ptpn6 Nras Zap70 Hras Cd247 Ikbkb Grb2 Traf6 Prkcq Rasgrp1 Csk Cd3g Sos1 Map3k8 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor Bcl2 Thrb Nr1h2 Med1 Rps6kb1 Ppara Tgfb1 Rxrg Rara Ppard Rxrb Fam120b Rxra Vdr Ncoa1 Rarg Ncor2 Thra Srebf1 Nr1h3 Nr4a1 Abca1 Nr1h4 Pparg NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway Aph1b Hdac1 Rbbp8 Cdkn1a Cbl Btrc Psenen Ctbp1 Dlk1 Ncstn Neurl1 LOC100911293 Ccnd1 Notch2 Notch1 Dll3 Rab11a Lnx1 Mib1 Gata3 Notch4 Notch3 Myc Eno1 Maml1 Cntn6 Cul1 Mark2 Yy1 Kdm1a Cntn1 Ptcra Adam12 Furin Il4 Hdac1l Skp2 Dll4 Dnm1 Ncor2 Skp1 Mfap5 Jag1 Dner Mfap2 DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors Dusp1 Hdac2 Epha2 Irf5 Dusp5 Htt LOC502894 Carm1 Tp53inp1 Pcna Pou4f2 Cx3cl1 Tp73 Cse1l Bak1 Tgfa Prdm1 Edn2 Prmt1 Plk3 Hgf Cd82 Tada2b Serpine1 Smarca4 Col18a1 LOC100911519 Tsc2 Gadd45a Ddit4 Pml Apc Tp63 Btg2 Rnf144b Pms2 Gpx1 Bid LOC100910137 Msh2 Mmp2 Perp Bnip3l Tp53bp2 Pycard Mlh1 Hspa1a E2f1 E2f3 Hspa1b Rchy1 Ppp1r13b Fas Sh2d1a Kat2a Ccng1 Atf3 Bcl2 Tap1 Tyrp1 Steap3 Igfbp3 Taf9 Ctsd Lif Serpinb5 Cebpz Triap1 Rrm2b Bcl2l2 Bcl2l14 Crebbp Bcl6 Drosha Gdf15 Ddx5 Sesn1 Ccnk Prkab1 Casp1 Ppm1j Egfr Vcan Nlrc4 Pidd1 Rb1 Dgcr8 Pcbp4 Fdxr Bdkrb2 Zfp385a Nfyc Nfyb Mdm2 Nfya Ndrg1 Cdkn1a Apaf1 Dkk1 Bcl2l1 Pten Sfn Jun Casp6 Bcl2a1 Vdr Foxa1 Sp1 Afp Spp1 Tp53 Bax BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions Itgb7 Vcam1 Itgb8 Itgb6 Itga4 Fn1 Tgfbr1 Vtn Cyr61 Plau Fbn1 Madcam1 POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly Ctnnd1 Ptpn1 Cdh2 Fyn LOC100909750 Iqgap1 Src Rac1 Nme1 Gna13 Gna12 Abl1 Arf6 Slit1 Rin2 Cdh1 Crebbp Ret Casp3 Rab7a Gdnf Cables1 Robo1 Bdnf LOC100910807 Zbtb33 Mmp7 Dsp Ptpn6 Egfr Hras Cbll1 Jup Igf1r Igf2 Ntrk2 Dnm2 Snx1 Tiam1 Ctnna1 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network Brca1 Hdac1 Set Calcoco1 Mta1 Tff1 Apbb1 Pcna Safb Pou4f2 Med1 Cd82 Col18a1 Jun Chuk Ncoa1 Ncor2 Esr1 Ccnd1 Hdac4 Esr2 Hsf2 Ctsd Dscam Myc Ebag9 Ube2m Ndufv3 Xbp1 Lmo4 Prdm15 Atp5j Nr0b2 Ncoa7 Nedd8 Anp32a Nr0b1 Pgr Stat5a Nrip1 Hdac1l Prl C3 Uba3 Ncoa2 Sra1 Mpg Axin2 Phb2 Ddx54 Ap1b1 Sod1 Abca3 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling Dusp1 Sh2d2a Rala Iqgap1 Bcl2l1 Brk1 Abi1 Baiap2 Mapk1 Mapk8 Rac1 Src Mlst8 Kras Sfn Raf1 Atf2 Prkca Fos Actr3 Map2k2 Actr2 Jun Pld2 Nckap1 Gab1 Pld1 Arpc3 Egr1 Ywhaz Bad Arpc4 F2rl2 Arpc5 Ywhab Mapkap1 Arpc2 Arpc1b Nras Vav2 Ywhag Ywhah Ppp2ca Prkcd Ppp2r1a Map3k2 Ppp5c Ksr1 Ralgds Srf Mylpf Arf4 Rps6ka3 Ppp2r2a Usp6nl Eps8 Slc9a1 Map2k5 Mef2c Atf1 Dusp6 Rps6ka5 Rin1 Ywhae Smad1 Capn2 LOC100911794 Pik3cb Akt1 Rictor Map2k4 Creb1 LOC100911372 Rps6 Prkcz Stat3 Stat1 Pebp1 Map2k1 Pdpk1 Pik3r1 Hras Egfr Elk1 Grb2 LOC100912399 Mapk9 Map3k1 Sos1 Mtor VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods Rpe65 Gucy2f Rgs9 Rgs9bp Guca1b Gnb5 Grk1 Guca1a Rho Pde6b Cnga1 Gucy2d Pde6a Lrat Gnb1 Gnat1 Gngt1 Sag INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 Ube2d3 Cblb LOC100910792 Cbl Chmp3 Tsg101 Ube2d1 Spry2 Stambp Arhgef7 LOC100909679 Synj1 Itsn1 Epn1 Pik3cb Lrig1 Zfyve28 Amph Usp8 Src Kras Raf1 Ptk2 Sh3kbp1 Shc1 Sh3gl2 Pik3r1 Nras Hras Egfr Grb2 Dnm1 Sos1 CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events Cbl Yes1 Arhgef7 Enah Iqgap1 Map2k6 Baiap2 Mapk1 Src Limk1 Rac1 Mapk8 Cfl1 Bcar1 Atf2 Exoc7 Raf1 Iqgap3 Actr3 Actr2 Jun Arhgdia Pld1 Arpc3 Cdh1 Pak2 Pard6a Pak1 Arpc4 F2rl2 Arpc5 Pak4 Gsk3b Arpc2 Arpc1b Vav2 Apc Mapk14 Tiam1 Ctnna1 Limk2 Sept2 Eps8 Hes5 Tnk2 Dlg1 Pax6 Arhgef6 Cdc42bpa Map2k4 Prkcz Rps6kb1 Pik3r1 Hras LOC100912399 Map2k7 Mapk9 Map3k1 Mtor Map3k11 REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling Mapk1 Smad2 Ube2i Pias4 LOC100912399 Ctdsp1 Nup153 Map3k1 Ctdspl Kpnb1 Smad3 Kpna2 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events Ptk2b Gsn Vav3 Plau Mmp2 Mapk1 Cd44 Mapk8 Rac1 Ilk Bcar1 Fos Nfkb1 Rock2 Spp1 Jun Chuk Mmp9 Pik3r1 Rela Map3k14 LOC100912399 Rhoa Syk Map3k1 Nfkbia INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis Vcl Vtn Cbl Vav3 Csf1r Mfge8 Mapk1 Src Csf1 Rac1 Col11a1 Col11a2 Bcar1 Col4a1 Col4a3 Col5a2 Fn1 Tgfbr2 Col4a5 Col5a1 Fgf2 Vegfa Col6a2 Pi4kb Ptk2 Angptl3 Col6a1 Col3a1 Pik3c2a Irs1 Rock1 Rhoa F11r LOC100911572 Ptk2b Tln1 Casp8 Akt1 Ilk Spp1 Col1a2 Col1a1 Pxn Rps6kb1 Pik3r1 Cdkn1b Igf1r Ptpn11 LOC103692716 NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network Hif1a Hdac1 Hey2 Hey1 Twist1 Rbbp8 Tle1 Parp1 Ptf1a Gaa Gata4 Gata1 Ctbp1 LOC100911167 Arnt E2f1 Notch1 Ar Hes1 Maml1 Stat3 Yy1 Crebbp Kdm1a Cd4 Hdac1l Cdkn1b Ncoa1 Neurog3 Hes6 Myod1 Rb1 Ncor2 Runx2 Camk2d Bglap Ascl1 Ghr ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins Crk Edn2 Plcb2 Edn1 Gnao1 Mapk1 Src Gnai3 Rac1 Mapk8 Gna15 Bcar1 Gna14 Prkca Raf1 Gna12 Fos Gna11 Map2k2 Gnaq Jun Col3a1 Mmp1 Cysltr2 Cysltr1 Ednrb Edn3 Slc9a3 Rhoa Mapk14 Prkcd Pla2g4a Ptk2b Trpc6 Slc9a1 Gnai2 Adcy7 Adcy8 Gnai1 Adcy6 Gnaz Adcy4 Adcy5 Adcy3 Akt1 Gnal Plcb3 Plcb1 Ednra Col1a2 Map2k1 Prkch Prkcb Hras Prkcq CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events Pik3r6 Blk Yes1 Rhoc Rhob Crk Plcb2 Cxcl12 Gnao1 Rac1 Gnai3 Src Limk1 Mlst8 Cfl1 Bcar1 Gna13 Ptk2 Mmp9 Bad Pak1 Ptprc Mapkap1 Fgr Pik3cg Rhoa Cxcr4 Csk Arrb2 Rap1b Lck Ssh1 Ptk2b Fyn Gnai2 Ralb Grk6 Gnai1 Gnaz Rgs1 Pik3cb Adrbk1 Arr3 RT1-Da RT1-Db1 Akt1 Vps4a Vps4b Gnb1 Ubqln1 Rictor Stat2 Plcb3 Plcb1 Vav1 Prkcz Hck Stat3 Pxn Stat1 Foxo1 Cd4 Cd3d Cd3e Pik3r1 Pdpk1 Stat5a Ptpn6 Cd247 Lyn Ptpn11 Dnm1 Cd3g Stat5b Mtor PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway Csnk2a1 Fos Srf LOC100911248 Jun Plcg1 Shc1 Crk Crkl Pik3r1 Shf Pdgfra Cav3 Elk1 Jak1 Grb2 Sos1 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases Aurkb Aurka REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta Dusp1 Lck Blk Yes1 Fyn Ralb Rala Map2k6 Ripk1 Mapk11 Map3k3 Map2k4 Rac1 Src Map3k12 Hck Pak2 Dusp10 Pak3 Pak1 Dusp16 Fgr Lyn Mapk14 Traf6 PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events F2rl2 Gna15 Gna14 Gna13 Rock1 Gna11 Rock2 Gnaq Plcb2 Rhoa F2 Gnb1 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions Cd40lg Fgg Cyr61 Plau Itgax Fga Fgb Vcam1 Spon2 F10 Icam1 Thy1 Gp1ba C3 Jam3 Icam2 Plat Itgal Proc Itgb2 Itgam LOC103693683 F11r REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription Hdac2 Hdac1 Tle1 Btrc Dkk1 Ctbp1 Id2 Smarca4 Myf5 Camk4 Myog Hbp1 Cby1 Sfn Ctnnbip1 Lef1 Tcf7l1 Dvl3 Jun Klf4 Tnik Pitx2 Tbl1xr1 Tcf4 Cdh1 Dkk4 Ywhaz Mmp9 Mt-co2 Aes Ywhab Ywhag Apc Ywhah Sp5 Tbl1x Krt1 Tcf7 Igf2bp1 Neurog1 Cyr61 Cdkn2a Adcy7 Ywhae Fgf4 Chd8 Cdx4 Mmp2 Zcchc12 Kcnip4 Med12 T Ruvbl2 Cacna1g Tle2 Tle4 Ccnd1 Mitf Ar Incenp Myc Xpo1 Cul1 Tert Hdac1l Ncoa2 Vcan Axin2 Skp1 PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway Pik3r6 Ptpn2 Blk Cbl Grb10 Yes1 Ptprj Crk Iqgap1 Brk1 Abi1 Baiap2 Rac1 Bcar1 Prkca Actr3 Map2k2 Actr2 Arhgdia Nckap1 Arpc3 Pak1 Arpc4 Arpc5 Arpc2 Arpc1b Fgr Pik3cg Rhoa Cttn Dnm2 Prkcd Rap1b Srf Sphk1 Slc9a3r2 Jund Lrp1 LOC364561 Actn4 Arap1 Mapk10 Ywhae Pdgfb Pdgfrb LOC100909750 Pik3cb Myc Abl1 Pin1 Arhgap35 Slc9a3r1 Map2k1 Sipa1 Myocd Rasa1 Rab4a S1pr1 Eif2ak2 Hras Tagln Elk1 Mapk9 Sos1 Mapk1 Mapk8 Src Pten Kras Sfn Raf1 Fos Dok1 Jun Gab1 Ywhaz Shc1 Ywhab Vav2 Nras Ywhag Ywhah Csk Ppp2ca Ppp2r1a Nck1 Lck Ksr1 Pla2g4a Rps6ka3 Plcg1 Usp6nl Eps8 Ptpn1 Fyn Map2k4 Rap1a Hck Stat3 Stat1 Pik3r1 Stat5a Nck2 Lyn Grb2 Map2k7 Ptpn11 Stat5b S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway Mapk1 Gnai2 Gnao1 Gnai3 Gnai1 Gnaz Gna13 Gna12 Rhoa S1pr5 Plcg1 S1pr4 GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway Gpc2 JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway Map2k4 Mapk8 LOC100911248 Jun Lat Crk Crkl Map3k7 Lcp2 Prkcb LOC100912399 Map3k1 Map3k8 Dbnl Map4k1 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events Ect2 Gorasp1 Cdc20 Cdc14b Kif2a Tpt1 Cenpu Bub1b Bora Stag2 Plk1 Btrc Fbxo5 Rab1a Kiz Tubg1 Ppp1cb Cdc25c Cdc25b Fzr1 Cenpe Fbxw11 Bub1 Ndc80 Rock2 Incenp Sgol1 Pak1 Wee1 Kif20a Tpx2 Rhoa Golga2 Ppp1r12a Aurka Ninl Ppp2ca Spc24 Cdk1 Clspn Ercc6l Ppp2r1a Prc1 REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity LOC100912512 Git1 Plcg1 Vav3 Arhgef6 Arhgef7 Itsn1 Dock6 Dnmbp Ngef Mcf2l Ralbp1 Arhgap1 Spata13 Nme1 Dock11 Itsn2 Arhgap17 Bcar3 Arhgef25 Fgd1 Arhgdia Racgap1 Vav2 Apc Farp2 BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions Vtn Itga7 Itga6 Mdk Itga5 Col18a1 Col11a1 Col11a2 Col4a1 Lama1 Col4a3 Col5a2 Itga4 Fn1 Col4a5 Itga11 Col5a1 Vegfa Col6a2 Itga10 Col6a1 Col3a1 Itga8 Itgb1 LOC100911572 Cspg4 Thbs2 Igsf8 Cd81 Plau Fbn1 Cd14 Fgg Itga3 Spp1 Col1a2 Col1a1 Tgm2 F13a1 Fga Fgb Vcam1 Lama4 Nid1 Lamb2 Lamb3 Lamb1 Lamc1 Lamc2 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells Dusp1 Cblb Cbl Mapk1 Mapk8 Raf1 Fos Dok1 Map2k2 Nfkb1 Jun Pld2 Ptk2 Chuk Pak2 Shc1 Fcgr2b Rela Fer Ikbkb Syk Sphk1 Fcer1a Pla2g4a Itk Plcg1 Hcls1 Pla2g1b Ptpn13 Fyn Wipf1 Lat2 Ppap2a Akt1 Map2k4 Nfatc2 Gab2 Vav1 Lat Pxn Map2k1 Lcp2 Pik3r1 Prkcb Rasa1 S1pr1 Hras Lyn Grb2 Map2k7 LOC100912399 Ptpn11 Map3k1 Sos1 NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway Arrb2 Yes1 Mapk10 Wnt5a Cthrc1 Nfatc2 Mapk8 Rac1 Ror2 Dvl3 Camk2a Daam1 Fzd6 Tab2 Prkcz Fzd5 Fzd2 Map3k7 Chd7 Flna Nlk Rock1 Dvl1 Csnk1a1 Rhoa Mapk9 Pparg CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events Gnai2 Gnai1 Gnaz Pik3cb Map2k6 Akt1 Gnb1 Mapk11 Rictor Gnao1 Ccl11 Mapk1 Mlst8 Gnai3 Src Kras Cxcl11 Cxcl13 Raf1 Cxcl10 Arrb1 Pf4 Map2k2 Cxcr3 Cxcl9 Map2k1 Pdpk1 Pik3r1 Mapkap1 Nras Hras Mapk14 Dnm1 Mtor NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling LOC100911248 Crk Crkl Mapk1 Rac1 Kras Gab1 Ntrk1 Ngf Shc1 Ngfr Nras Gipc1 Rhoa Sqstm1 Prkci Maged1 Tiam1 Rit1 Rit2 Rap1b Shc2 Plcg1 Ntf4 Ehd4 Ntf3 LOC100909609 LOC100909750 Mcf2l Ccnd1 Dock1 Gab2 Dynlt1 Matk Faim Rgs19 Rhog Rap1a Shc3 Abl1 Prkcz Stat3 Map2k1 Pik3r1 Bdnf Rasa1 Hras Dnaja3 Frs2 Grb2 Frs3 Ptpn11 Dnm1 Ntrk3 Ntrk2 Sos1 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling Incenp Aurkb CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin Mapk1 Map2k4 Map2k1 Pgr Vcam1 Casp1 Map2k2 Map2k7 Map2k6 Il1b Antxr1 Il18 SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP Ptpn2 Ptpn1 Pdgfb Csf1r Pdgfrb Jak1 Pik3cb Hgf Pias1 Csf1 Src Atr Ins2 Gab1 Vegfa Stat3 Crebbp Stat1 Shc1 Kpna2 Pik3r1 Stat5a Jak3 Stat6 Rab4a Lman1 Insr Egfr Eif2ak2 Grb2 Itgb1 Kpnb1 Stat5b Sos1 INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport Ppp1r3a Sfn Gys1 Ins2 Rhoq Prkcz Stxbp4 Ywhaz Ywhae Ywhab Ppp1cc Stx4 Gsk3b Insr Ywhag Ywhah Akt2 Vamp2 Prkci Akt1 Slc2a4 RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway Mapk1 Ptpn7 Map2k1 Kras Prkcb Raf1 Prkca Nras Fos Hras Elk1 Map3k8 COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity Brca1 Carm1 Med1 Vav3 Pias3 Pias1 Nkx3-1 Kdm3a Snurf Fkbp4 Ncoa6 Tgfb1i1 Tmprss2 Ncoa4 Lats2 Svil Mak Hip1 Tcf4 Prkdc Zmiz1 Tgif1 Cdk6 Zfp318 Prdx1 Pa2g4 Ccnd3 Pawr Srf Ptk2b Rps6ka3 Gsn Cdkn2a Xrcc5 Casp8 Xrcc6 Ube2i Pias4 Ctdsp1 Ccnd1 Akt1 Pelp1 Fhl2 Ube3a Ar Kdm1a Nrip1 Uba3 Ncoa2 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones Rpe65 Gucy2f Cngb3 Gnat2 Pde6c Gngt2 Slc24a2 Gnb3 Rgs9 Rgs9bp Guca1b Gnb5 Pde6h Grk1 Guca1a Arr3 Gucy2d Lrat ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events Smad5 Amh Smad1 Amhr2 Fkbp1a Acvr1 Bmp7 Bmpr2 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling Pik3r6 Blk Yes1 Ptgdr Ptgir Tbxa2r Sele Ptgdrl Plcb2 Mapk11 Src Rac1 Gna15 Rab11a Gna14 Prkca Gna13 Gna12 Gna11 Gnaq Gnb5 Fgr Rock1 Pik3cg Mapk14 Rhoa Syk Prkcd Arrb2 Lck Fyn Gnai2 Adrbk1 Arr3 Akt1 Gnb1 Prkaca Hck Prkcz Tgm2 Slc9a3r1 Nos3 Prkch Vcam1 Prkcb Icam1 Egfr Lyn Dnm1 Prkcq A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling Ywhae Itga6 Itgb4 Akt1 Rac1 Sfn Prkca Mst1r Lama1 Erbb3 Il1a Col17a1 Pmp22 Mst1 Cdh1 Ywhaz Shc1 Rps6kb1 Rxrg Ywhab Pik3r1 Rxrb Erbb2 Hras Rxra Ywhag Egfr Ywhah Lama4 Grb2 Lamb2 Itgb1 Lamb3 Lamb1 Lamc1 Lamc2 P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases Tsc2 Creb1 Sfn Raf1 Srf Mapkapk2 Ywhaz Hspb1 Cdc25b Mapkapk3 Ywhae Lsp1 Ywhab Etv1 Th Ywhag Ywhah Mapk14 Mapk11 POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle Plk4 Plk2 Plk1 Plk3 IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events Cbl Fes Thy1 Jak1 Bcl2l1 aicda Fcer2 Socs1 Mybl1 Dok2 Il4r Socs5 Irs2 Shc1 Il4 Irs1 Mapk14 Ets1 Cd40lg Il2rg Selp Arg1 Il13ra1 Il13ra2 Sp1 Retnlg Tff3 Il10 Parp14 Oprm1 Lta Hmga1 Pigr LOC100360218 Akt1 Ccl17 Egr2 Alox15 Ccl11 Col1a2 Socs3 Col1a1 Bcl6 Rps6kb1 Pik3r1 Spi1 Stat5a Stat6 Jak3 Ptpn6 Grb2 Stat5b Il5 Mtor EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway Ephb2 Efnb1 Efnb2 Ephb3 Ephb1 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling Zfyve9 Arrb2 Wwp1 Dact2 Tgfbr1 Strap Ppp1r15a Ppp1ca Ppp2r2a Dab2 Xiap Smad7 Tgfb3 Bambi Zfyve16 Sptbn1 Ywhae Ppp2cb Smad2 Eif2a Smurf1 Tgfbr3 Daxx Dynlrb1 Ctgf Fkbp1a Tgfbr2 Camk2a Tab2 Shc1 Pard6a Pml Rps6kb1 Map3k7 Tgfb1 Pdpk1 Grb2 Ppp2ca Smad3 Sos1 SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta Ptgs2 Pla2g4a Mapkapk2 Slc9a1 Mef2c Atf1 Rps6ka5 Esr1 Ddit3 Eif4ebp1 Mapk11 Creb1 Hbp1 Atf2 Mitf Jun Hspb1 Mapkapk3 Ppargc1a LOC497963 Krt8 Mapk14 Atf6 Mknk1 Elk4 Tp53 Mapkapk5 Usf1 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 Ccna2 Jund Plau Gja1 Cdkn2a Mmp2 Sp1 Itgb4 Junb Ccnd1 Il6 Nfatc2 Lif Nfatc3 Jun Col1a2 Mgp Dmtf1 Thbd Txlng Mmp9 Hmox1 Fosl1 Mmp1 Nos3 Ccl12 Dcn Atf4 Bglap SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events Fgfr4 Fgf19 Fgfr3 Fgf23 Hgf Hpse Mapk1 Col11a1 Ppib Col11a2 Bsg Col4a1 Prkaca Col4a3 Col5a2 Col1a2 Col4a5 Col5a1 Col1a1 Col6a2 Mmp9 Col6a1 Ccl5 Col3a1 Mmp1 Tgfb1 Sdcbp Mmp7 LOC100911572 IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway Rap1b Ptpn2 LOC100911248 Cbl Smad7 Crkl Jak1 Pias4 Akt1 Pias1 Dapk1 Ifng Mapk1 Socs1 Irf9 Rap1a Ptges2 Camk2a Stat3 Crebbp Stat1 Map2k1 Ifngr1 Pik3r1 Casp1 Irf1 LOC100912399 Ptpn11 Map3k1 Camk2d Il1b Camk2g Prkcd Mtor Map3k11 SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events Fgfr4 Fgf19 Fgfr3 Sdc2 Mmp2 Fgf23 Ezr Trappc4 Cav2 Epb4.1 Nf1 Mapk1 Src Mapk8 Prkaca Lama1 Fn1 Casp3 Tgfb1 Sdcbp Csf2 Rasa1 Ephb2 Hras Rhoa Itgb1 Bax Prkcd TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway Map2k4 Mapk1 Mapk8 Smpd1 Traf2 Cflar Chuk Casp8 Tradd Pik3r1 Dap3 Tnfsf10 Ikbkb Pik3cb LOC100912399 Map3k1 Ripk1 Fadd VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network Esr2 Ube2m Zfp709 Smarce1 Smarcb1 Nr0b2 Nedd8 Nr0b1 C3 Uba3 Ncoa2 Ncoa1 Ddx54 Smarca4 THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway F2 SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression Pias2 Hdac4 Hdac1 Mdm2 Hdac1l Ube2i Xpo1 Pias1 Ran Ranbp2 CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis Birc2 Parp1 Apaf1 Tnfrsf1a Xiap Diablo Gsn Bid Tradd Casp8 Ripk1 Srebf1 Cfl2 Birc3 LOC100911519 Krt18 Cradd Limk1 Bcl2 Numa1 Sptan1 Traf2 Tfap2a Madd Lmna Gas2 Top1 Arhgdib Dffb Acta1 Ptk2 Lmnb2 Dffa Satb1 Casp3 Lmnb1 Casp2 Casp6 Casp4 Casp9 Casp1 Vim App Pidd1 LOC100912399 Map3k1 Bax Cycs IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events Tbx21 Il18r1 Lck Ripk2 Il12rb2 Faslg Ccl4 Nfkb2 Ccr5 Il1r1 Sphk2 Hlx Il12a Il2rg Il12b Gzma RT1-Da RT1-Db1 Map2k6 Ifng Socs1 Atf2 Fos Nfkb1 Gadd45g B2m Stat3 Stat1 Gadd45b Cd8b Cd4 Cd8a Cd3d Rab7a Cd3e Il4 Stat5a Rela Stat6 Il2ra LOC497963 Cd247 Mapk14 Il1b Cd3g Mtor Il18 Il2 S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway Gnao1 S1pr2 Mapk1 Gnai3 Rac1 Mapk8 Gna15 Cdh5 Gna14 Gna13 Fos Gna12 Gna11 Gnaq Jun Pak1 Gnai2 Gnai1 Gnaz Irs1 Elk1 Rhoa Mapk14 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway Gnao1 S1pr2 Gnai3 Gna15 Gna14 Gna13 Gna12 Gna11 Gnaq Sphk1 S1pr3 Sphk2 Gnai2 Sgpl1 Gnai1 LOC688708 Gnaz S1pr1 S1pr5 S1pr4 RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway Vcl Srf Pip5k1c Limk2 Cyr61 Slc9a1 Tln1 Diaph1 Ezr Map2k6 Rdx Map2k4 Limk1 Mkl1 Mapk8 Cfl1 Pten Cit Pkn2 Atf2 Fos Rock2 Jun Pld2 Pld1 Acta1 Prkcz Pip5k1b Pard6a F2rl2 Sh3gl2 Slc9a3 Rock1 Cdkn1b Rhoa Ppp1r12a Itgb1 Scai Pkn1 Mapk12 Msn VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation Mta1 Cdc25a Kat5 Id2 Nbn Nme1 Mmp9 Fosl1 Mtdh Cdk4 Actl6a Snai1 Serpini1 Ireb2 Prdx3 Rpl11 Lin28b LOC100911431 Slc2a1 Eif4a1 Ruvbl1 Bcat1 Hspa4 Polr3d Hspd1 Odc1 Eif4g1 Eif2s1 Myct1 Supt7l Pdcd10 Ubtf Cad Shmt1 Ddx18 LOC680559 Bmi1 Gpam Tfrc Ruvbl2 E2f3 Hmga1 Kat2a Max Taf9 Myc Eno1 Tert Crebbp LOC103692716 Tp53 Smad3 Bax Npm1 Pim1 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network Kit Ccna1 Tom1 Trim28 Cdkn1a Myf6 Anpep LOC100363915 Hipk2 H2afz Gata1 Cd34 LOC100911167 Smarca2 Atp2b1 Csf1r Pias3 Iqgap1 Kras Lef1 Tab2 Ppp3ca Map3k7 Casp6 Nras Cdk6 Ets1 Snd1 Ptgs2 Elane Kitlg Mat2a Lect2 Zfhx3 Ets2 Yeats4 Gstm7 Mpo Cbx4 Cebpa LOC100911324 Slc25a3 Maf Car1 Ppidl1 Cdkn2a Sp1 Rag2 Ube2i Adora2b Ccnd1 Ada Mcm4 Prtn3 Birc3 Mad1l1 Bcl2 Sin3a Gata3 Myc Col1a2 Hes1 Wnt1 Clta Crebbp Cd4 Ptcra Spi1 Nlk Hras Cdkn1b Myod1 Pim1 CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling Cd40lg Pik3r6 Birc2 Cblb Traf3 Mapk10 Cd40 Tdp2 Fcamr C4bpa Pik3cb Bcl2l1 Akt1 Birc3 Mapk11 Map2k4 Mapk8 Traf2 Nfkb1 Myc Jun Pik3r1 Il4 Stat5a Rela Jak3 Map3k14 Pik3cg Mapk14 LOC100912399 Traf6 Mapk9 Map3k1 Nfkbia REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation Nf1 Rabgef1 Syngap1 Kras Rras Lgals3 Prkca Lgals1 Prkcz Rin1 Rasgrp2 Prkcb LOC100911794 Rasa1 Nras Hras Grb2 Rasgrp3 Rasgrp1 Rasal1 Rasgrp4 Sos1 Plce1 Rasa2 ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions Itgb7 Cdh1 IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 Ccna2 Lck Faslg Il2rg Sp1 Jak1 Lta Bcl2l1 Bcl2 Gab2 Myc Shc1 Il4 Pik3r1 Elf1 Stat5a Jak3 Foxp3 Il2ra Cdk6 Grb2 Ptpn11 Sos1 Stat5b Ccnd3 Il2 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling Zfand5 Cat Rbl2 Fbxo32 Csnk1g1 Faslg Csnk1g2 Plk1 Mapk10 Ralb Ywhae Rala Sod2 Csnk1d Csnk1g3 Csnk1e Usp7 Akt1 Mapk8 Sfn G6pc Xpo1 Mst1 Chuk Gadd45a Ywhaz Crebbp Bcl6 Foxo1 Foxo3 Ywhab Sgk1 Ywhag Cdk2 Ywhah Cdkn1b Skp2 Foxo4 Ikbkb Csnk1a1 Mapk9 Bcl2l11 Ran SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II Srf Gata1 Mef2c LOC100911167 Ranbp2 Ywhae Esr1 LOC100360129 Ankra2 Hdac6 Rfxank Ube2i Adrbk1 Gnb1 Hdac3 Camk4 Hdac4 LOC100910438 Xpo1 Hdac11 Hdac10 Gata2 Bcl6 Ywhab Tubb2a Ncor2 LOC103692716 Ran CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway Atr Stt3a Timeless Wdr5 Bhlhe40 Arntl LOC100911602 Npas2 Cry1 Per2 Nono Csnk1e Clock Nr1d1 Cry2 Per1 CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway Cul3 Pi4k2a Ppp2r5a Gsk3a Csnk1g1 Dvl3 Wnt3 Pip5k1b Wnt3a Ranbp3 Fzd5 Nkd2 Klhl12 Gsk3b Lrp6 Apc Dvl1 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network Mdm2 Hey2 Stt3a Ccna2 LOC100911267 Cdkn1a Kat5 Plk1 Tp73 Rad51 Bak1 Gata1 LOC100911167 Jak1 Plk3 Serpine1 Mapk11 Sfn Il4r Ntrk1 Pml Casp2 Foxo3 Rela Cdk2 Cdk6 Bin1 Tp63 Mapk14 Bcl2l11 Cdk1 LOC364561 Sp1 Ppap2a Afp LOC100909750 Ndufs2 Rchy1 Ccne2 Ada Prkacb Fas Ube4b Brca2 Bub1 Rnf43 Aen Nsg1 Gramd4 Dedd Pea15 Serpina1 Myc Clca2 Abl1 Flot2 Hsf1 Pfdn5 Dcp1b Hagh Il1rap Pin1 Gdf15 Wt1 Rb1 Bax BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling Chrdl1 Smad5 Grem1 Rgma Hfe2 Bmp6 Bmp2 Sostdc1 Nog Ppp1r15a Ppp1ca Xiap Smad7 Bambi Zfyve16 Smad1 Smurf1 Ctdsp1 Ctdspl Bmp7 Bmpr2 Mapk1 Tab2 Bmp4 Map3k7 Gsk3b Smad6 Chrd Fst ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway Fkbp1a Acvrl1 Acvr1 VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms Wwp1 Mdm2 Shh Cdkn1a Plk1 Btrc Cdkn2a Perp Sp1 Itgb4 Gpx2 Nqo1 LOC100909750 Ssrp1 Traf4 Spata18 Evpl Ada Dicer1 Fas Dhrs3 Tfap2c Egr2 Noc2l Mfge8 Aen Ogg1 Hbp1 Smarcd3 Igfbp3 Itga3 Clca2 Serpinb5 Abl1 Flot2 Chuk Gadd45a Pml Gdf15 Cables1 Vdr Ikbkb Tp63 Jag1 Bax Fdxr Prkcd EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling Fyn GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network Hdac2 Hdac1 Mdm2 Tbx21 Tbp Cdk5 Cdkn1a Tsg101 Sele Il6 Smarca4 Mapk11 Mapk1 Mapk8 Sfn Fkbp4 Fos Nfkb1 Jun Egr1 Il13 Smarcc2 Mmp1 Fkbp5 Il4 Nr1i3 Suv420h1 Csf2 Csn2 Gsk3b Rela Sgk1 Pou1f1 Smarcc1 Ywhah Cga Ncoa1 Krt17 Mapk14 Krt14 Smarcd1 Pou2f1 Ppp5c Pomc Mapk10 Afp Akt1 Prkacb Ifng Creb1 Cdk5r1 Fgg Gata3 Prkaca Crebbp Stat1 Spi1 Stat5a Icam1 Hdac1l Prl Irf1 Ncoa2 Mapk9 LOC103692716 Tp53 Nr4a1 Bglap Stat5b Bax Il5 Il2 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity Pou2f1 Hdac1 Mdm2 Carm1 Kat5 Smarce1 Cebpa Hoxb13 Dnaja1 Senp1 Smarca2 Appbp2 Trim24 Kat7 Ehmt2 Pde9a Zmiz2 Nr2c2 Nr2c1 Spdef Rchy1 Map2k6 Map2k4 Mapk8 Src Tmprss2 Ar Jun Gata2 Egr1 Crebbp Foxo1 Rxrg Nr0b1 Gsk3b Hdac1l Rxrb Smarcc1 Rxra Ncoa2 Ncoa1 Mapk14 LOC103692716 Pkn1 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions L1cam Cd47 Sphk1 Vtn Ibsp Cyr61 Plau Fbn1 Pdgfb Pdgfrb Itga2b Thy1 Sdc4 Fgg Col4a1 Col4a3 Fn1 Tgfbr2 Spp1 Col1a2 Col4a5 Vegfa Col1a1 Fga Fgb Lama4 Lamb1 F11r Lamc1 LOC100911572 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway Epha2 Epha3 Epha8 Epha4 Epha7 DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin Gsk3a Dvl3 Wnt3 Btrc Cul1 Wnt3a Fzd5 Gsk3b Lrp6 Apc Dvl1 Csnk1a1 Csnk1d Axin2 Skp1 Csnk1e S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway Mapk1 Gnao1 Rac1 Ptgs2 Gnai3 Sphk1 Vegfa Plcg1 Gnai2 Pdgfb Gnai1 LOC688708 Pdgfrb Gnaz S1pr1 Rhoa Plcb2 REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity Ect2 LOC100912512 Arhgef15 Vav3 Arap1 Ngef Mcf2l Trio Vav1 Arhgef25 Arhgef18 Arhgdia Def6 Arhgdib Farp1 Arhgef3 Arhgef5 Arhgap5 Arhgef11 Arhgef28 Arhgap35 Arhgap9 Net1 Ophn1 Srgap1 Abr Vav2 Arhgap8 Myo9b Cdkn1b Rhoa Arhgef2 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network Dusp1 Mafg Agt Dmp1 Junb Nppa Fabp4 Nts Mt2A Edn1 Il6 Cbfb Timp1 Penk Bag1 Pten Atf2 Fos Jun Acta1 Gata2 Egr1 Mmp9 Fosl1 Mmp1 Il4 Th Csf2 Ets1 Bcl2l11 Cdk1 Hif1a Jund Cyr61 Maf Plau Gja1 Cdkn2a Esr1 Sp1 Il10 Ccnd1 Ifng Atf3 Nfatc2 Creb1 Nfatc3 Myc Col1a2 Dmtf1 Tgfb1 Elf1 Ccl12 Cdkn1b Tp53 Il5 Il2 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling Cpeb1 Brca1 Ajuba Ccnl2 Mdm2 Dlgap5 Git1 Ckap5 Ndel1 Tacc3 Oaz1 Cdc25b Fzr1 Arhgef7 Akt1 Prkaca Cenpa Gadd45a Pak1 Rasa1 Gsk3b Tpx2 Aurkb Aurka Tacc1 Nfkbia Tp53 Ran INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway Nck1 Cbl Grb10 Ptpra Ptpn1 Rhoq Crk Exoc5 Exoc3 Akt1 Eif4ebp1 Exoc7 Dok1 Ins2 Exoc2 Prkcz Shc1 Rps6kb1 Exoc6 Pard6a F2rl2 Foxo3 Pdpk1 Pik3r1 Rasa1 Sgk1 Insr Hras Irs1 Akt2 Nck2 Grb2 Ptpn11 Sh2b2 Grb14 Prkci Sorbs1 Sos1 RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling Hdac1 Akt1 Hdac3 Mapk1 Mapk8 Prkca Prkaca Crebbp Rbp1 Rxrg Mnat1 Rara Ccnh Nrip1 Rxrb Hdac1l Cdk7 Rxra Vdr Ncoa2 Ncoa1 Mapk14 Rarg Ncor2 Cdk1 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events Erc1 Ube2n Il1r1 Map2k6 Il1rn Map3k3 Tollip Mapk8 Il1r2 Ticam2 LOC100362142 Nfkb1 Il1a Jun Tab2 Chuk Prkcz LOC100912618 Irak3 Irak4 Ube2v1 Il1rap Map3k7 Pik3r1 Rela Casp1 Myd88 Ikbkb Sqstm1 Traf6 Prkci Il1b LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events Stradb Strada Stk26 Brsk1 Sik1 Stk11ip Mark4 Psen2 Etv4 Stk11 Cdc37 Cab39 Ywhae Esr1 Map2 Ezr Tsc2 Creb1 Mlst8 Tsc1 Smarcd3 Sfn Prkaca Ctsd Myc Rptor Mark2 Ywhaz Ywhab Gsk3b Ywhag Ywhah LOC103692716 Tp53 Mtor Akt1s1 GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network Mdk Gpc2 E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network Brca1 Cdc6 Hdac1 Rbl2 Trim28 Ccna2 Rbbp8 Cdkn1a Cdc25a Topbp1 Apaf1 Tp73 Smarca2 Dhfr E2f6 E2f7 E2f5 Uxt Ranbp1 Xrcc1 Serpine1 Hbp1 Yy1 Wasf1 Cdk2 Cdk1 Ccnd3 Cebpa Plau Cdkn2a Sp1 E2f3 E2f1 Ccne2 Ccne1 Kat2a Tyms RGD1565297 Ces4a Tfdp2 Prmt5 Atm Rrm2 Tfe3 Myc Mybl2 Orc1 Mcm3 Ces2h Sult2a1 Ces5a Crebbp Cdkn2c Ces1d Rbl1 Hdac1l Cdkn1b Cbx5 Rb1 HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha Tceb1 Os9 Hif1a Hif3a Vhl Egln3 Egln2 Rbx1 Hif1an Cul2 Arnt Cdkn2a LOC103692716 Tp53 TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells Cbl Sla2 Kras Pten Prkca Bcl10 Chuk Shc1 Fyb Ptprc Sh3bp2 Stk39 Nras Ikbkb Csk Nck1 Lck Itk Plcg1 Fyn RT1-Da RT1-Db1 Akt1 Gab2 Cd86 Orai1 Vav1 Rap1a Cd28 Rassf5 Lat Cd80 Trpv6 Cd4 Cd3d Lcp2 Cd3e Pdpk1 Prkcb Rasgrp2 Stim1 Flna Ptpn6 Map3k14 Hras Zap70 Cd247 Grb2 Ptpn11 Traf6 Prkcq Rasgrp1 Cd3g Sos1 Map3k8 Dbnl Map4k1 IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events Il18r1 Mpo Il12b Il6 Ifng Il23a Il17f Il17a Itga3 Nfkb1 Socs3 Cxcl9 Stat3 Stat1 Cd4 Pik3r1 Cd3e Ccl12 Stat5a Rela LOC497963 Il23r Il1b Il19 Nfkbia Alox12b Il18 Il24 Il2 Cxcl3 EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway LOC100911248 Cbl Plcg1 Crkl Bcl2l1 Mapk8 Bcl2 Rap1a Epo Nfkb1 Tec Socs3 Gab1 Epor Irs2 Stat1 Shc1 Pik3r1 Stat5a Ptpn6 Vav2 Hras Lyn Mapk14 Grb2 Ptpn11 Sos1 Stat5b HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network Ndrg1 Egln3 Arnt Hk2 Nt5e Plin2 Bhlhe41 Id2 Serpine1 Edn1 Abcg2 Cxcl12 Pgk1 Adm Cp Aldoa Fech Fos Epo Abcb1a Lep Jun Tf Pfkfb3 Vegfa Cited2 Bnip3 Rora Gata2 Pgm1 Pfkl Pkm Car9 Bhlhe40 Ncoa1 Cxcr4 Ets1 Slc2a1 Hnf4a Hif1a Igfbp1 Tfrc Sp1 Tff3 Itgb2 Akt1 Creb1 Eno1 Tert Crebbp Hmox1 Furin LOC497963 Ncoa2 Smad3 Npm1 LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events Adcy7 Adcy8 Creb1 Adcy6 Adcy4 Prkaca Adcy5 Lpar4 Adcy3 Gnal Rps6ka5 NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte Cd2ap Arrb2 Nck1 Trpc6 Plcg1 Fyn Mapk10 Kirrel Pik3cb Tjp1 Nphs1 Nphs2 Akt1 Map2k4 Mapk8 Rac1 Jun Prkcz Pard6a Bad F2rl2 Pik3r1 Nck2 Grb2 Mapk9 Prkci ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events Arrb2 Epha2 Nck1 Lhcgr Gulp1 Acap2 Fbxo8 Kif13b Git1 Cyth3 Efna1 Itga2b Acap1 Hgf Tshr Src Cyth2 Gna15 LOC100360745 Gna14 Arrb1 Agtr1a Gna11 Gnaq Arf6 Pxn Egfr Adrb2 PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events Trpc6 Snx2 F2r Gnai2 Gnai1 Vasp Gnaz Zyx Plcb2 F2 Gnb1 Gnao1 Gnai3 Plcb3 Gna15 Gna14 Plcb1 Prkca Gna13 Arrb1 Gna12 Gna11 Rock2 Gnaq Arhgdia F2rl2 Nos3 Pik3r1 Prkcb Rock1 Rhoa Dnm1 Dnm2 Pkn1 Snx1 Prkcd E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction Rap1b Pip5k1c Ctnnd1 Dlg1 Crk Itgb7 Enah Iqgap1 Tjp1 Abi1 Ccnd1 Akt1 Rac1 Src Nme1 Rap1a Nckap1 Arf6 Cdh1 Pik3r1 Klhl20 Ap1m1 Vav2 Jup Rhoa Cttn Ctnna1 Tiam1 ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events Smad5 Arrb2 Mapk1 Fkbp1a Tgfbr2 Tgfbr1 Acvrl1 Ppp1ca Smad7 Tgfb3 Tgfb1 Smad1 Id1 Acvr2b Acvr2a Acvr1 Gdf2 Csnk2b Bmpr2 Inhba PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling Aph1b Hdac1 Tle1 Btrc Psenen Dkk1 Ctbp1 Ncstn Psen1 LOC100911293 Fbxw11 Ccnd1 Mapk1 Notch1 Csnk2a1 Fzd1 Fos Hnf1a Kremen2 Myc Jun Wnt1 Crebbp Aes Wif1 Map3k7 Ppard Hdac1l Gsk3b Nlk Apc Lrp6 Dvl1 Csnk1a1 Dkk2 Nkd1 CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events Pik3r6 Lck Blk Itk Plcg1 Cyth3 Yes1 Fyn Pik3cb Arf5 Src Rac1 Cyth1 Cyth2 Kras Pten Rap1a Plekha1 Arf6 Lat Hck Foxo3 Blnk Pdpk1 Pik3r1 Fgr Nras Sgk1 Zap70 Hras Pik3cg Dapp1 Lyn Rhoa Syk LOC103692716 E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events Jup Cdh1 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events Mapk1 Map2k1 Pik3r6 Pde3b Pik3cg IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events Il17a Tbx21 Gata3 Il12rb2 Il6st Stat3 Il27ra Il12a Stat1 Ebi3 Il12b Tgfb1 Stat5a Jak1 Il1b Il6 Il18 Ifng Stat2 Il2 PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events Plk4 Plk2 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network Pdgfb Pdgfrb Pdgfra Pdgfa Pdgfc E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes Rac1 Src Ajuba Ctnnd1 Plcg1 Cdh1 Fyn Pik3r1 Vasp Zyx Egfr Casr Jup Akt2 Rhoa Akt1 Ctnna1 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling Hdac2 Hdac1 Cdkn1a Zbtb17 Smad7 Ctbp1 Smad2 Pias3 E2f5 Serpine1 Cbfb Atf2 Fos Jun Tgif1 Foxo3 Cdk4 Cdk2 Vdr Ncoa1 Hnf4a Foxg1 Nkx2-5 Ifnb1 Runx1 Cited1 Runx3 Dlx1 Irf7 Dcp1a Gsc Foxh1 Skil Mef2c Med15 Snip1 Esr1 Sp1 Il10 Pias4 Akt1 Kat2a Atf3 Creb1 Sin3a Max Gata3 Ar Tfe3 Myc Col1a2 Sap18 Crebbp Foxo1 Rbl1 Rbbp7 RGD1561590 Hdac1l Cdkn2b Ncoa2 Foxo4 Myod1 Runx2 Smad3 Lamc1 Il5 SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL Mapk1 Rac1 Src Bcar1 Ccna2 Cdkn1a Egr1 Rhoc Agt Rock1 Cdk2 Rhoa Itgb1 Ptp4a3 Ptp4a1 Ccne1 Atf5 Rabggtb Rabggta IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events Mapkapk2 Jak1 Mapk11 Mapk1 Mapk8 Kras Socs1 Raf1 Fos Dok2 Map2k2 Jun Irs2 Shc1 Stam2 Ikzf3 Nras Stam Irs1 Cdk2 Mapk14 Rhoa Syk Lck Ptk2b Fyn Il2rg Ifng Bcl2 Gab2 Myc Socs3 Stat3 Stat1 Cish Map2k1 Pik3r1 Prkcb Stat5a Rasa1 Jak3 Il2ra Hras Grb2 Mapk9 Ptpn11 Stat5b Sos1 Il2 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling Rap1b Lrp1 Plau Tln1 Selp Mmp2 Thy1 Jam3 Ctgf Plat Itgb2 Itgam Il6 Mst1r Rap1a Plg Nfkb1 Mst1 Apob Selplg Hck Ager Mmp9 Icam1 Rock1 Rhoa REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein Hdac1 Mdm2 Ccna2 Tbp Cdkn1a Ctbp1 Suv39h1 Atf7 Rbp2 Dnmt1 Suv39h1l1 Pax3 Hdac3 Smarca4 Ckm Brd2 Aatf Mapk11 Atf2 Raf1 Jun Cdk4 Csf2 Cdk2 Cdk6 Mapk14 Ppp2ca Ccnd3 Pparg Ubtf Cbx4 Gsc Smarcb1 Cebpa Mef2c Cdkn2a LOC100909750 E2f3 E2f1 Ccnd1 Ccne1 Tgfb2 Mitf Abl1 Crebbp Elf1 Spi1 Hdac1l Cdkn1b Skp2 Myod1 Mapk9 Rb1 Runx2 Bglap SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B Lck Blk Nox4 Capn1 Ybx1 Lepr Ptpn1 Yes1 Cdh2 Crk Fyn Pdgfb Spry2 Csf1r Pdgfrb Itga2b Leprot Akt1 Txn1 Csf1 Src Bcar1 Dok1 Ins2 Lep Socs3 Lat Hck Stat3 Trpv6 Shc1 Pik3r1 Stat5a Csn2 Prl Fgr Fer Insr Irs1 Egfr Lyn Grb2 Rhoa Csk LOC103693683 Stat5b CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway Asah1 Prkra Bag4 Ksr1 Smpd3 Aifm1 Tnfrsf1a Sphk2 Bid Tradd Casp8 Akt1 Ripk1 Birc3 Fadd Mapk1 Map2k4 Cradd Smpd1 Mapk8 Bcl2 Traf2 Raf1 Madd Ctsd Myc Map2k2 Nfkb1 Pdgfa Prkcz Bad Map2k1 Rela Eif2ak2 LOC100912399 Map3k1 Nfkbia Bax Cycs Prkcd Pawr CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt Gsk3a Kpna1 Cdkn1a Ywhae Akt3 Bcl2l1 Akt1 Rictor Src Mlst8 Sfn Raf1 Prkaca Prkdc Chuk Ywhaz Foxo1 Bad Foxo3 Casp9 Ywhab Pdpk1 Gsk3b Mapkap1 Ywhag Ywhah Cdkn1b Akt2 Foxo4 LOC103692716 Mtor Slc2a4 PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events Chek2 Plk3 Tp53 Ccne1 Cdc25c INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling Parp1 Ckap5 Cdc37 Tacc3 Diaph1 Arhgef6 Arhgef7 Zyx Ruvbl2 Iqgap1 Ccnd1 Akt1 Rictor Ilkap Ppp1r14b Creb1 Ilk Rac1 Zeb1 Tns1 Ppp1r14c Rhog Ppp1r14a Jun Lims2 Naca Xpo1 Git2 Myl9 Elmo2 Parva Pxn Parvb Snai1 Gsk3b Nck2 Ppp1r12a Aurka LOC103692716 Actn1 Ruvbl1 VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms Wwp1 Ppp2r5a Mdm2 Runx1 Nrg1 Adrm1 Hells Stxbp4 LOC100911660 Rrad Cdkn2a Rab38 Sec14l2 Dlx5 Perp Axl Gpx2 T Mre11a Ada Notch1 Brca2 Hbp1 Sfn Igfbp3 Itga3 Atm Tcf7l1 Il1a Hes1 Col5a1 Gsk3b Vdr Tp63 Krt14 Bdkrb2 DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells Ptpn7 Ifnar1 LOC100912356 Tnfrsf4 Egr4 Tnfrsf9 Faslg Il2rg Junb Ifng Nfatc2 Mapk1 Mapk8 Kras Prkca Raf1 Fos Nfatc3 Map2k2 Jun B2m Egr1 Stat1 Cd8b Cd8a Cd3d Fosl1 Map2k1 Cd3e Prkcb Nras Hras Il2ra Cd247 Elk1 Mapk9 Prkcq Cd3g Il2 LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development Rac1 Dynlt1 Cdk5r1 Csnk2a1 Dync1h1 Lrpap1 Dab1 Lrp8 Cdk5r2 Cdk5 Pafah1b3 Abl1 Pla2g7 Dcx Ndel1 Katna1 Ywhae Reln LOC100909750 Iqgap1 Rhoa Vldlr Map1b Pafah1b1 ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network Erbb3 Nrg1 Tgfa Nrg4 Nrg3 Erbb2 Egfr Ereg Areg Btc Erbb4 LOC103692716 Nrg2 Hbegf EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling Map2k4 Rac1 Mapk8 Src Lck Blk Efnb1 Efnb2 Ephb1 Hck Yes1 Fyn Ptpn13 Map3k7 Pik3r1 Itga2b Fgr Ephb2 Nck2 Lyn Dnm1 Rgs3 Tiam1 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway Mdm2 Stt3a Trim28 Ccna2 Csnk1g1 Ppp2r4 Csnk1g2 Chek2 Kat5 Cse1l Hipk2 Setd8 Setd7 Rassf1 Fbxo11 Ube2d1 Kat8 Smyd2 Ttc5 Rpl23 Ppm1d Daxx LOC100909949 Dyrk2 Mdm4 E4f1 Csnk1d Csnk1g3 Csnk1e Usp7 Mapk8 Yy1 Gsk3b Rpl11 Cdk2 Mapk14 Ppp2ca Prkcd LOC364561 Cdkn2a LOC100909750 Rchy1 Akt1 Ccng1 Atr Prmt5 Atm Abl1 Crebbp Nedd8 Pin1 Skp2 Csnk1a1 Mapk9 Tp53 FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network Pou2f1 Brca1 Shh Tff1 Vtn Foxa1 Esr1 Sp1 Foxa2 Col18a1 Foxa3 Pisd Nkx3-1 Nfic Nfib C4bpb Fos Dscam Ar Ins2 Serpina1 Jun Ndufv3 Nr2f2 Apob Xbp1 Prdm15 Atp5j Scgb1a1 Crebbp Gcg Sftpa1 Nrip1 Cdkn1b Ap1b1 Sod1 PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling Gnai2 Esr1 Gnai1 Mmp2 Gnaz Plcb2 Akt1 Gnal Gnb1 Hbegf Mapk11 Gnao1 Pelp1 Gnai3 Src Plcb3 Gna15 Kras Bcar1 Plcb1 Gna14 Esr2 Gna13 Gna11 Rock2 Gnaq Strn Mmp9 Shc1 Nos3 Pik3r1 Nras Hras Igf1r Grb2 Rhoa Sos1 Msn ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling Hspd1 Chuk Irak4 Sftpa1 Cd14 Tlr2 Tlr3 Myd88 Vcan Ikbkb Rhoa Irak2 Tirap Tlr4 Tlr6 S100a9 S100a8 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events Arrb2 Pik3r6 Rac2 Cxcr2 Cbl Gnai2 Vasp Plcb2 Akt1 Gnb1 Plcb3 Rab11a Gna15 Gna14 Plcb1 Prkca Arrb1 Pld2 Hck Rab7a Pdpk1 Prkcb Fgr Pik3cg Lyn Dnm1 Ppp2ca Ppp2r1a EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway Nck1 Pip5k1c Plcg1 Ptpn1 Gsn Tln1 Gnai1 Pik3cb Mapk1 Gnai3 Src Kras Gab1 Ptk2 Stat3 Shc1 Stat1 Pak1 Pik3r1 Rasa1 Ptpn6 Nras Hras Egfr Nck2 Grb2 Ptpn11 Sos1 ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network Dusp1 Brca1 Dusp5 Ccna2 Kat5 Sele Ddit3 Junb Bcl2l1 Il6 Cbfb Mapk11 Il23a Mapk1 Mapk8 Prkca Atf2 Fos Jun Gadd45a Cdk4 Ppargc1a Th Mapk14 Pou2f1 Jund Jdp2 Plau H2afy Csrp2 Hbg1 Arg1 Esr1 Mmp2 Pdgfra Ruvbl2 Ccnd1 Tgfb2 Ifng Atf3 Cul3 Nf1 Bcl2 Creb1 Ins2 Serpinb5 Hes1 Socs3 Dusp10 LOC497963 Mapk9 Rb1 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events Wwp1 Mdm2 Nrg1 Fyn Cbfa2t3 Pik3cb Dlg4 Lrig1 Hbegf Mapk1 Adam17 Tab2 Shc1 Pik3r1 Stat5a Nrg4 Prl Nrg3 Erbb2 Ereg Grb2 Btc Erbb4 Stat5b Grin2b Nrg2 ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling Nck1 Cdkn1a Fes Tek Crk Fyn Elf2 Mmp2 Itga5 Angpt4 Angpt2 Bmx F2 Akt1 Mapk1 Rac1 Mapk8 Dok2 Plg Agtr1a Fn1 Nfkb1 Pld2 Fgf2 Ptk2 Shc1 Pxn Foxo1 Rps6kb1 Pak1 Grb7 Nos3 Elf1 Pik3r1 Stat5a Rela Rasa1 Angpt1 Elk1 Grb2 Mapk14 Ptpn11 Ets1 Itgb1 Grb14 Stat5b CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes Pou2f1 Ptgs2 Batf3 Cd40lg Tbx21 Egr4 Faslg Cblb Ptpn1 Maf E2f1 Junb Ifng Egr2 Nfatc2 Fos Gata3 Nfatc3 Jun Dgka Slc3a2 Egr3 Egr1 Casp3 Fosl1 Cdk4 Il4 Csf2 Foxp3 Il2ra Prkcq Il5 Pparg Il2 FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network Gsk3a Ccna2 Chek2 Plk1 Tgfa Cdc25b Cdkn2a Esr1 Mmp2 Sp1 Xrcc1 Hspa1a Hspa1b Ccnd1 Ccne1 Cks1l Brca2 Cenpf Foxm1 Etv5 Fos Onecut1 Cks1b Nfatc3 Myc Cenpa Crebbp Map2k1 Cdk4 Cdk2 Skp2 Lama4 Aurkb Rb1 Cdk1 IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events Arrb2 Plcb3 Gna15 Pik3r6 Gna14 Plcb1 Prkca Arrb1 Cbl Pld1 Hck Gnai2 Pdpk1 Prkcb Fgr Pik3cg Lyn Adrbk1 Plcb2 Dnm1 Cxcr1 Akt1 Gnb1 EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling Rap1b Nck1 Crk Synj1 Itsn1 Mapk1 Kalrn Src Rac1 Rras Kras Rap1a Efnb1 Tf Efnb2 Ephb3 Ephb1 Ptk2 Shc1 Pxn Pak1 Grb7 Map2k1 Pik3r1 Rasa1 Ephb2 Nras Rock1 Hras Efnb3 Grb2 Dnm1 SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I Hdac2 Hdac1 Hdac8 Mta2 Mbd2 Mbd3 Btrc Smad7 Gata1 LOC100911167 Wdr77 Fkbp3 Smurf1 Hdac6 Gatad2a LOC100911453 Chd3 Gatad2b Chd4 Hdac3 Sirt6 Sirt5 Sirt4 Nfkb1 Hdac11 Hdac10 Gata2 Yy1 Rela Ncor2 Pparg Tnfrsf1a Ranbp2 Nr2c1 Ube2i Hdac4 Sirt2 Sin3a Sirt3 Max Prmt5 Prkaca Mxd1 Sap18 Xpo1 Smg5 Stat3 Crebbp Rbbp7 RGD1561590 Hdac1l Nfkbia Ran SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) Kit Kitlg LOC100911248 Cbl Grb10 Crkl Akt1 Bcl2 Mapk8 Socs1 Pten Matk Raf1 Vav1 Epo Dok1 Mitf Tec Map2k2 Epor Gab1 Stat3 Crebbp Stat1 Shc1 Rps6kb1 Bad Pik3c2b Foxo3 Spred1 Map2k1 Pik3r1 Spred2 Pdpk1 Stat5a Gsk3b Fer Ptpn6 Ptpro Hras Stap1 Lyn Grb2 Ptpn11 Sh2b2 Sos1 Map4k1 ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway Map3k14 Nfkb1 Nfkb2 Btrc Chuk A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling Itgb7 Vcam1 Itga4 Rhoa Itgb1 Ptk2 Pxn Madcam1 TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway Bag4 Cyld Birc2 Tnfrsf1a Tradd Casp8 Ripk1 Birc3 Fadd Map3k3 Txn1 Smpd1 Traf2 Adam17 Madd Smpd2 Nfkb1 Map4k5 Nsmaf Tnik Rffl Tab2 Map4k3 Chuk Tnfrsf1b Prkcz Map4k2 Stat1 Nrk Map3k7 Rela Ikbkb LOC100912399 Map2k7 Sqstm1 Map3k1 Prkci C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway Hbp1 Ppp2r5a Max Taf9 Myc Supt7l Zbtb17 Kat5 Pak2 LOC364561 Pml Pin1 Cdkn2a Actl6a Gsk3b Skp2 Ruvbl2 Ppp2ca Ruvbl1 Kat2a VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network Nrp1 Vegfc Figf Pgf Flt4 LOC100911280 Vegfa Flt1 Nrp2 ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events Nrg1 Mapk10 Pik3cb Akt1 Chrna1 Usp8 Nfatc4 Mapk1 Nf2 Src Rac1 Mapk8 Chrne Kras Rnf41 Raf1 Fos Prkaca Erbb3 Map2k2 Jun Stat3 Shc1 Ppp3cb Bad Map2k1 Pik3r1 Erbb2 Nras Hras Grb2 Ptpn11 Mapk9 Sos1 Nrg2 Mtor FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway Ssh1 Ptk2b Cbl Ctnnd1 Plcg1 Fgfr4 Fgf19 Plau Fgfr3 Sdc2 Cdh2 Spry2 Fgf23 Akt1 Mapk1 Src Rps6ka1 Fos Spp1 Jun Camk2a Gab1 Cdh1 Fgfr1 Mmp9 Stat1 Shc1 Pak4 Pdpk1 Pik3r1 Fgfr2 Fgf1 Il17rd Ncam1 Frs2 Grb2 Ptpn11 Cttn Runx2 Stat5b Sos1 Bglap S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway Gnai2 Gnao1 Gnai3 Gnai1 Gnaz Gna12 Rhoa S1pr5 BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events Brca1 Fancd2 Rbbp8 LOC100911267 Pcna LOC100912481 Ube2d3 Topbp1 Fancl Rad51 Fanca Ewsr1 Fancf Cstf1 Fancc Bard1 Xrcc5 Fance Xrcc6 Mre11a Nbn Ccne1 Atr Atm Rad50 Prkdc Ube2l3 Cdk2 Tp53 SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase Vcl Yes1 Crk Arhgef7 Itga5 Mapk1 Src Rac1 Mapk8 Bcar1 Raf1 Jun Ptk2 Acta1 Grb7 Pak1 Rhoa Ets1 Itgb1 Actn1 Mapk8ip3 Rap1b Nck1 Plcg1 Arhgap26 Tln1 Fyn Capn2 LOC100909609 Bmx Ccnd1 Dock1 Map2k4 Rras Rap1a Rock2 Git2 Asap1 Pxn Arhgef11 Arhgef28 Arhgap35 Map2k1 Pik3r1 Rasa1 Nck2 Grb2 Mapk9 Sos1 HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network Tceb1 Vhl Twist1 Egln3 Egln2 Hif1an Efna1 Arnt Eif3e Apex1 Epas1 Slc11a2 Pou5f1 Sp1 Mmp14 Adora2a Serpine1 Abcg2 Pgk1 Epo LOC100911280 Vegfa Flt1 Cited2 Crebbp Bhlhe40 Elk1 Ets1 Slc2a1 GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network Tdgf1 Serpinc1 Lck Blk Tgfbr1 Nrg1 Yes1 Tgfb3 Fyn Smad2 Pla2g2a Slit2 Prnp Src Lama1 Tgfbr2 LOC100911280 Vegfa Fgf2 Flt1 Hck Fgfr1 Tgfb1 Fgr Lyn App ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions Itga6 Lama1 Itgb4 Lamb2 Lamb3 Lamb1 Lamc1 Lamc2 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta Mapk13 Stmn1 Snta1 Map2k6 Eef2k Ccnd1 Pkn1 Mapk12 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling Elane Vtn Lrp1 Plau Crk Pdgfrb Itga5 LOC100909609 Hgf Itgb2 Itgam Serpine1 Dock1 Src Rac1 Bcar1 Itga3 Fgg Plg Fn1 Mmp9 Fpr2 Fga Fpr3 Tgfb1 Fgb Fpr1 Ctsg Egfr Vldlr Itgb1 Gpld1 Mmp13 Mmp12 Klk4 Ctrc HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins Mtss1 Hdac2 Arrb2 Hdac1 Sufu Rab23 Ift88 Shh Ptch1 Csnk1g1 Spop Csnk1g2 Gli1 Gli2 Btrc Kif3a Stk36 Gnai2 Gnai1 Gnaz Csnk1d Csnk1g3 Fbxw11 Smo Csnk1e Akt1 Pias1 Foxa2 Gnb1 Gnao1 Gnai3 Sin3a Lgals3 Prkaca Sap18 Xpo1 Crebbp Rbbp7 Map2k1 RGD1561590 Gsk3b Hdac1l Csnk1a1 Prkcd REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity LOC100912512 Eps8 Vav3 Arhgef6 Arhgef7 LOC100909609 Dock6 Ngef Ralbp1 Trio Abi1 Dock1 Arhgap1 Spata13 Kalrn Rac1 Arhgap17 Rap1gds1 Vav1 Prex1 Arhgef25 Prex2 Arhgdia Def6 Racgap1 Arhgap9 Abr Vav2 Sos1 Arhgef2 Tiam1 IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 Pias2 Tbx21 Il18r1 RT1-Da RT1-Db1 Ifng Mapk8 Cd86 Etv5 Fos Jun Cd28 Cd80 Il13 Crebbp Stat3 Stat1 Cd4 Cd3d Tgfb1 Cd3e Irf1 Il2ra Cd247 Mapk9 Cd3g Il18 Il2 HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha Bag4 Faslg Tnfrsf1a Apaf1 Cflar Bid Tradd Casp8 Daxx Ripk1 Fas Birc3 Fadd Cradd Bcl2 Mapk8 Traf2 Nfkb1 Chuk Casp3 Casp2 Casp6 Casp9 Rela Map3k14 Cd247 Map2k7 Nfkbia Cycs