ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-RNO-111447.1 Activation of BAD and translocation to mitochondria 29748 24224 25577 171378 313017 29753 25576 64625 298795 56011 56010 64639 DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME DATABASE ID RELEASE 60%9438360 Downstream signaling of activated FGFR3 79114 81504 170633 25513 170700 313845 54250 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 361388 25114 25738 25022 29368 116499 25622 60662 85385 170582 24525 66017 60464 BIOTIN TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 60%9438474 Biotin transport and metabolism 116719 170551 24624 294972 302422 361884 288240 25104 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 60%9438703 Lysosphingolipid and LPA receptors 314649 295401 500317 116744 60399 498609 66025 29733 29415 306792 C-SRC MEDIATED REGULATION OF CX43 FUNCTION AND CLOSURE OF GAP JUNCTIONS%REACTOME%R-RNO-191647.1 c-src mediated regulation of Cx43 function and closure of gap junctions 24392 292994 83805 TIE2 SIGNALING%REACTOME%R-RNO-210993.1 Tie2 Signaling 313845 296269 290361 89807 29741 89804 89805 84427 293621 85243 24605 25622 85385 81504 25513 24525 FORMATION OF APOPTOSOME%REACTOME%R-RNO-111458.1 Formation of apoptosome 25309 100363502 78963 58918 ARACHIDONATE PRODUCTION FROM DAG%REACTOME%R-RNO-426048.1 Arachidonate production from DAG 309207 304289 305795 499913 29254 NUCLEOTIDE EXCISION REPAIR%REACTOME%R-RNO-5696398.1 Nucleotide Excision Repair 361181 171150 289561 294693 116468 497967 304343 288003 103690054 245976 301442 298508 364834 361365 303369 287367 363283 312710 500225 25737 84389 64156 292778 690966 289758 261736 301382 313098 103692172 59102 363273 361107 308415 288651 293494 287927 50522 310707 691642 81822 502227 362394 246216 300813 314061 117017 89809 298012 83503 298074 360471 300222 296084 315523 24919 25591 81513 291703 362479 681260 498109 100361574 312560 304528 366163 64470 100911295 292673 59294 363633 300084 287524 310071 498837 266713 361698 361925 116725 100912032 100362121 360915 65137 296883 84495 291737 306274 360704 100912534 294236 302502 288414 316440 498453 499417 361580 84593 100911727 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%R-RNO-72737.1 Cap-dependent Translation Initiation 64156 299872 100360057 367195 100360619 100911847 81729 681260 498837 100912032 103692785 140655 362952 287417 360572 292964 367865 103690821 100912571 367265 100910180 294282 116636 29236 100360647 100911575 140662 100364265 100360841 103690015 684988 691531 295975 140661 64640 29283 56783 29284 103692831 28298 287436 100360679 26962 64302 302697 103693375 290641 689284 362041 192234 295660 300253 100360117 296709 103694404 117019 296302 317646 29288 81767 29282 81763 100360522 81768 81765 81769 64205 288599 311120 301299 100362830 292148 690468 314652 81775 293427 81770 29752 64638 81776 292762 299027 25348 300069 306079 103694169 293484 288516 65139 297756 64514 100912182 300079 171145 298700 117045 25347 682793 100910370 685963 124440 306926 691947 687780 29258 54318 100911110 100359922 161477 65043 25538 499782 100361079 303831 ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 60%9438367 Oncogene Induced Senescence 314856 304798 114483 100910954 50522 116590 498837 100912032 681260 64156 304063 94201 25261 50689 24356 292721 54238 25164 APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME%R-RNO-351906.1 Apoptotic cleavage of cell adhesion proteins 307562 25402 83502 291755 291752 SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 60%9439183 SHC-mediated cascade:FGFR1 313845 54250 25443 25444 170579 293621 25317 170583 29349 24605 29368 116499 60662 85385 79114 81504 170633 24525 66017 170700 LEADING STRAND SYNTHESIS%REACTOME%R-RNO-69109.1 Leading Strand Synthesis 59294 25737 116468 304528 288003 289758 288414 85242 361698 301323 246327 89809 NEUTROPHIL DEGRANULATION%REACTOME%R-RNO-6798695.1 Neutrophil degranulation 100364062 298682 498300 294673 289924 192264 252902 306324 24590 24206 24591 29645 63880 299314 683849 305679 252915 100909700 361208 306332 574531 83578 100909977 306871 315949 100360977 102557319 58826 50692 282817 171293 299331 306891 316033 306600 292072 498840 50645 316035 499271 302495 58970 688730 361537 689064 292073 292804 303542 24191 499985 302890 303413 170538 290029 361635 293118 58857 289185 690130 308869 303414 308875 499157 316014 364867 140868 170667 313658 59313 305234 100360087 295234 316516 499285 116591 50866 63849 361516 316519 295347 303353 679787 100362805 306760 681706 313648 29543 365183 445415 304822 501742 362638 498276 291948 100910990 361378 29153 304966 287709 690158 361677 365388 361171 361467 24157 24159 84397 361370 29142 312647 29511 29143 367915 24189 287721 24390 308632 94198 94197 361697 298066 310612 29714 287813 314618 314615 291000 310416 116590 291755 310553 50993 291339 499065 688047 299809 292666 299606 246272 29385 309147 308995 301535 84007 363024 64537 292668 314843 29398 25290 29565 116690 361819 29364 291085 291091 116689 499099 499933 292537 29448 315085 315084 83462 299052 295647 117284 25052 64035 362249 287427 690230 299277 79113 25581 292413 103694877 25441 116547 292419 25308 25455 292409 24426 103690020 64189 64185 65029 25046 292306 79209 308350 292594 54243 24917 54249 25319 29292 24944 79239 171361 113940 65197 84431 315272 54258 103694893 304485 116500 363494 690263 304988 171547 100361866 24926 367562 116967 113959 287435 170923 84586 295956 103690289 64159 65192 299159 83841 500361 100361543 114091 103690254 300857 171341 266775 689388 84497 171551 296356 299783 360914 293650 299276 289322 25531 25021 83730 288702 170496 304284 25406 56611 25151 286995 315348 362347 296321 315764 84491 25019 25407 288305 81641 81637 408247 690945 362045 306998 29192 362859 299121 103694857 81503 307483 156767 66021 297081 25227 362029 690492 289318 432363 81683 25524 25035 25328 362329 81687 25423 25528 117152 83806 24645 171337 83527 287670 498209 259275 290257 361422 311821 81506 24257 24256 25630 89824 83799 289231 81650 29184 498128 81649 289032 498234 192177 29738 309684 24251 362966 296654 296655 29186 24479 83781 252929 364705 312317 102554637 361598 310864 690906 60350 313087 29669 81679 363522 362432 25518 81675 289211 312316 25619 498022 24248 286958 114105 24232 363463 29757 294329 408224 289820 24691 288174 408229 290923 25505 81762 29677 100364984 689955 29672 297173 100125364 290409 311865 316333 298792 114023 287772 58949 282838 79129 287984 303666 25096 311078 79130 100909857 25095 100362738 24434 29662 100134871 81736 362893 313837 289632 24223 102557244 25374 29205 25373 100365047 301574 308666 360854 25739 288779 363127 84387 29214 301034 367455 293753 293154 307039 299732 94167 307821 84386 303180 317335 64350 24856 64529 246250 301005 64527 361619 308394 684322 613221 304688 498659 613225 301252 29221 296076 140656 296370 25741 293130 690198 691533 100361909 307833 304543 85274 295706 363247 140665 301261 100911825 474169 497195 84379 103693683 85492 116643 363875 246358 315306 304692 315222 25103 302526 292485 298508 78963 24605 PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME%R-RNO-8850843.1 Phosphate bond hydrolysis by NTPDase proteins 314312 361063 64519 309390 64467 316077 613267 85260 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME DATABASE ID RELEASE 60%9437940 IRS-related events triggered by IGF1R 291983 26954 171109 24514 246145 289924 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 58854 102552659 170668 29425 65179 24408 25167 64030 64562 287871 24716 24410 24412 56718 117281 24446 301518 498576 29675 298514 29671 29670 29376 24968 24967 29372 690919 25704 112400 29666 24337 24329 117263 117262 116663 364814 290206 24592 103694903 246273 64022 161475 308869 60445 360814 24703 64226 83499 24245 24244 338457 25267 309179 29614 29496 295234 29211 689852 64363 24497 652957 116630 140924 114103 24246 303353 24855 289257 84423 361992 84422 29668 81745 303605 29495 25614 292766 691318 25266 363131 362572 310091 360573 60427 24672 309168 365388 81827 24673 24482 292887 288924 171081 24242 291245 94198 296072 29630 81511 296651 408248 297960 304893 24483 24586 25746 301574 116590 307821 50689 100912571 116636 85492 25233 300253 83613 290291 312754 83803 24185 29516 65248 300980 66023 25525 25326 360776 314612 305203 312664 25136 65052 432361 287716 114858 58960 501146 192126 29542 192213 83840 25467 192117 295357 364052 246150 315648 117045 305614 299147 78975 288589 25400 25150 100909655 117044 59323 25344 171140 84598 170577 117043 59325 25433 25435 25676 310533 64156 50522 25581 89807 29741 89804 85243 83805 681260 64159 100361543 498837 100912032 362045 56011 79114 81504 170633 25513 83806 170700 313845 287670 54250 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 361388 25114 25022 29368 116499 25622 60662 85385 170582 24525 66017 60464 29669 29677 29672 287772 287984 311078 UNWINDING OF DNA%REACTOME DATABASE ID RELEASE 60%9438347 Unwinding of DNA 307639 499914 290842 292058 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 60%9438144 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components 171576 290875 361389 64515 297176 296558 296368 291689 360643 366381 498030 311412 100360936 361831 305420 304490 361662 293155 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME%R-RNO-5696395.1 Formation of Incision Complex in GG-NER 361181 171150 294693 301442 681260 84389 312560 64156 301382 313098 59102 64470 308415 288651 292673 287927 50522 300084 310707 287524 502227 498837 266713 300813 116725 100912032 100362121 298012 296883 298074 294236 302502 499417 361580 25591 84593 291703 HEDGEHOG LIGAND BIOGENESIS%REACTOME DATABASE ID RELEASE 60%9439130 Hedgehog ligand biogenesis 291983 289924 29499 314352 499241 25506 289990 58854 307821 29425 64156 289874 311324 362891 83806 287670 29675 50522 29671 29670 24968 25581 24967 29666 117263 117262 364814 290206 161475 85492 116643 83499 29614 29669 689852 303353 681260 287716 29668 292766 29677 29672 365388 81827 498837 287772 100912032 287984 311078 94198 29630 296651 408248 TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME DATABASE ID RELEASE 60%9438223 Transfer of LPS from LBP carrier to CD14 60350 29469 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME%R-RNO-70221.1 Glycogen breakdown (glycogenolysis) 24244 64035 81675 362029 29353 140671 367562 24242 64561 685076 289632 24645 24701 361377 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 60%9438022 Signaling by Interleukins 291983 171109 24514 289924 246145 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 58854 102552659 170668 29425 65179 24408 25167 64030 24716 24410 24412 117281 24446 498576 29675 29671 29670 29376 24968 24967 29372 690919 25704 112400 29666 24337 24329 117263 117262 116663 364814 290206 24592 103694903 64022 161475 360814 24703 83499 24245 24244 25267 309179 29614 29496 29211 295234 689852 64363 24497 652957 116630 140924 114103 24246 303353 289257 84423 84422 29668 29495 25614 292766 691318 25266 362572 360573 60427 24672 361677 309168 365388 81827 24673 288924 171081 24242 291245 94198 296072 29630 81511 296651 408248 304893 24586 25746 116590 25402 307821 50689 85492 83613 312754 300980 66023 25525 25326 314612 305203 312664 25136 432361 287716 114858 58960 192126 29542 192213 25467 192117 364052 246150 315648 305614 299147 288589 25400 25150 59323 25344 171140 84598 170577 59325 25433 25676 310533 117539 303024 296541 366508 303604 116470 500985 25493 689314 362896 311783 245983 363855 314322 81771 689932 308267 500616 363520 25610 288905 113894 64156 100360218 171060 116689 498003 155140 296390 25272 24498 171040 691516 81803 24494 24493 29201 81802 287398 50522 314870 25734 100912585 309157 315305 25581 89829 305549 114509 301365 81647 301059 100361294 297520 305451 287942 685840 309361 289014 81646 309165 29197 290655 84351 89807 89804 85243 83805 681260 64159 300084 498837 116725 100912032 362045 56011 25325 84477 252963 308716 291912 681112 79114 81504 170633 25513 83806 170700 313845 314384 287670 24500 54250 361749 25443 313121 25444 170579 310132 316213 304091 293621 500133 688622 314850 679539 25317 170583 25124 29348 81680 29349 444986 84489 171334 171333 24605 25125 25114 304061 25663 81649 25670 25022 29368 362418 305835 116499 25622 100363500 60662 361765 85385 362629 170582 362628 84492 315139 311245 25205 362417 25155 24525 114495 66017 60464 25156 116558 501043 171379 100910771 317546 25466 50658 29669 24932 361565 365395 54259 116596 303200 25556 681145 289747 315994 24918 100912618 312679 501560 171106 54245 291159 116554 367264 24516 116553 362356 25166 54237 100911248 29677 287287 63881 170819 29672 294797 81515 300177 309452 680609 301289 501996 682457 287772 691496 117269 287280 50646 287984 116996 313173 500836 311078 25707 362076 362077 309295 25084 298518 306247 307403 81736 362491 64546 60587 309957 84405 60584 GENE SILENCING BY RNA%REACTOME%R-RNO-211000.1 Gene Silencing by RNA 289561 103690054 364834 361365 292778 690966 117017 83503 102551184 53372 294429 311130 300259 299706 100360868 298533 680097 292085 117021 59117 304862 295277 100912489 117056 364723 58958 245922 113929 65274 103693372 498109 287830 100361574 308971 363006 84509 299284 291159 102548682 116555 362281 192178 25281 100360950 683983 295692 500351 291874 81738 499974 313593 363633 313594 679983 113975 691496 303774 102557184 25497 362335 100912534 POTASSIUM TRANSPORT CHANNELS%REACTOME%R-RNO-1296067.1 Potassium transport channels 29719 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME%R-RNO-382556.1 ABC-family proteins mediated transport 291983 289924 314352 289990 58854 307821 29425 64156 289874 362891 83806 287670 29675 50522 29671 29670 24968 24967 25581 29666 117263 363516 117262 84356 364814 302973 290206 155192 25559 85264 81642 300664 161475 85492 24891 116643 310836 140669 25303 25081 83499 29614 296302 29669 689852 303353 681260 287716 29668 292766 299027 29677 29672 365388 81827 498837 303638 25560 360967 287772 114628 100912032 287984 24646 116721 311078 286970 25270 407784 94198 83535 170913 54318 362912 29630 293939 296651 85493 408248 314537 63886 290823 299609 170924 83519 BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME%R-RNO-450385.1 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 29344 24185 103690064 679140 300045 313243 295050 294975 300944 366017 56011 100909830 361109 291604 316098 308441 289014 NEUROTRANSMITTER CLEARANCE%REACTOME%R-RNO-112311.1 Neurotransmitter clearance 29503 25553 24267 308868 24898 83817 29253 29539 COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME%R-RNO-6814122.1 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding 299809 24400 288620 50664 297406 25686 81664 60449 81667 25643 295230 24818 690155 365901 363143 25740 29481 294864 29374 294962 83579 64013 307641 116549 54296 286924 81650 288305 REGULATION OF FZD BY UBIQUITINATION%REACTOME DATABASE ID RELEASE 60%9439111 Regulation of FZD by ubiquitination 64558 50522 498837 100912032 500863 681260 303181 286994 64156 299802 499918 303412 498233 296121 313589 312781 498997 HDMS DEMETHYLATE HISTONES%REACTOME DATABASE ID RELEASE 60%9439139 HDMs demethylate histones 360665 500351 299557 317425 680097 679983 295277 100912489 364723 102557184 102548682 102551184 100360950 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 60%9438934 Translocation of GLUT4 to the plasma membrane 306117 313017 29753 81756 25576 298795 56011 360937 56010 81757 117103 25577 94197 PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME DATABASE ID RELEASE 60%9439190 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 192126 297173 293621 192117 25414 29372 360820 25597 314596 24605 288589 366275 309081 306400 54245 24592 361251 296072 362271 360814 304893 363875 24525 25676 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME%R-RNO-434316.1 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 29322 89788 81662 24654 266607 81666 309242 GABA SYNTHESIS%REACTOME%R-RNO-888568.1 GABA synthesis 24380 24379 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-629594.1 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors 170945 25102 25101 171131 25590 25302 65024 25103 81721 54239 79557 HDL CLEARANCE%REACTOME%R-RNO-8964011.1 HDL clearance 314459 64474 25073 80848 25081 COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 60%9439273 COPI-independent Golgi-to-ER retrograde traffic 360426 289350 362504 29167 114113 252902 294324 81655 362466 29564 83572 290798 84428 116659 307039 140734 308961 64189 292090 24653 299850 79214 84379 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 60%9437838 SLC-mediated transmembrane transport 171148 64076 100911721 363103 155205 291733 171144 171147 140447 140448 25550 25552 311651 170580 366251 266767 24782 24781 305846 287478 83612 84487 24780 310625 116509 314637 25548 290959 365398 171135 170573 363115 170567 305540 50719 317170 113918 25648 298340 294255 501103 24785 116726 25027 24783 170566 24784 84484 289459 29504 25139 29502 29509 170698 25658 29501 310392 302863 314396 24904 24778 24779 29715 310808 24244 58976 308028 313139 114629 295417 64018 306866 252919 117267 100158233 117261 282712 29440 316519 298280 29642 79213 311204 294281 79212 84550 84551 295645 65039 683667 299903 94106 89776 170943 64554 295455 58978 85426 664630 296600 64846 297386 303565 171373 140860 117955 25065 501925 50662 25059 58980 24546 291582 25351 366432 366441 252854 24242 192208 289353 308069 288499 192215 303205 295245 266612 65194 25693 300051 312192 29503 24898 363024 53372 294429 300259 299706 65197 292085 117021 304862 58958 245922 113929 65274 287830 116555 362281 25281 683983 295692 291874 81738 499974 113975 25497 362335 307811 29485 306009 140915 80878 85256 311387 25362 246239 294321 246235 83629 691209 353307 292657 25715 83511 29735 170551 287532 25634 432363 80899 83509 116642 302422 170840 503568 246234 65202 65200 500820 65207 29484 29483 365962 117100 293048 84608 50676 298786 80900 117240 114518 315439 50572 297910 114613 314441 363985 680602 304785 304784 63997 360539 64522 171163 24221 294698 29464 498185 84012 301010 361986 500973 84511 309111 311839 140944 311168 81826 29726 60423 54302 296969 315311 25246 24385 362861 116638 94172 259248 24268 29323 54301 681896 54300 100911440 KINESINS%REACTOME DATABASE ID RELEASE 60%9438874 Kinesins 362044 309159 171529 287624 314473 171304 84392 314906 84393 289168 296284 84391 362186 293502 85248 315298 315740 RHO GTPASES ACTIVATE IQGAPS%REACTOME DATABASE ID RELEASE 60%9439162 RHO GTPases activate IQGAPs 65201 24244 310621 361598 307505 24242 83502 363875 29417 64465 INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME%R-RNO-163754.1 Insulin effects increased synthesis of Xylulose-5-Phosphate 83688 64524 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME%R-RNO-381676.1 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 24400 25679 25262 685451 60449 81667 295347 25521 171026 64199 25289 25725 25051 294962 114120 64532 83579 246153 114118 293508 114119 114117 59326 25636 79218 29699 24679 24896 690825 100912034 83588 252857 680149 307234 24952 245986 29241 PTK6 DOWN-REGULATION%REACTOME%R-RNO-8849472.1 PTK6 Down-Regulation 366275 296472 24697 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 60%9438447 Formation of annular gap junctions 116563 83800 140694 25751 79128 116561 24392 METHIONINE SALVAGE PATHWAY%REACTOME DATABASE ID RELEASE 60%9438902 Methionine salvage pathway 305177 298227 298934 288912 CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-RNO-8856828.1 Clathrin-mediated endocytosis 288669 64678 54225 65046 317576 60443 500985 304343 25238 682507 84018 124461 313413 310839 192348 500244 314641 287367 79121 60465 363283 25710 312710 311880 309129 313409 25490 64156 60668 246310 24803 361244 261736 29491 24805 317396 60564 85238 363273 25716 50522 79128 116561 24329 116563 83800 25751 81732 24176 192154 192152 300678 303251 84357 25108 681260 363266 314349 308578 117028 117106 683687 266606 89816 498837 300438 81659 140670 290639 297518 100912032 361120 25387 360915 312689 83730 364033 29528 64566 24825 25388 312694 25151 85491 361632 81917 54241 500564 311030 81645 100909548 116743 498798 81637 64558 85256 360854 81504 24221 24932 289820 689955 GDP-FUCOSE BIOSYNTHESIS%REACTOME%R-RNO-6787639.1 GDP-fucose biosynthesis 291095 311204 293587 307848 300036 310935 100911225 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%R-RNO-416482.1 G alpha (12 13) signalling events 24400 246217 140898 310460 361223 78966 84009 310635 361921 64373 303634 363509 307098 296603 304109 687105 114559 117020 293024 100362710 366957 29491 292750 363460 25513 81663 310192 85384 316009 81762 301334 313845 310999 362648 24816 304193 297173 290541 311647 25537 309653 29413 29412 295378 363875 308875 25156 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME DATABASE ID RELEASE 60%9438755 Ras activation uopn Ca2+ infux through NMDA receptor 24245 24244 83613 192213 293621 246150 24246 25400 24242 291245 24408 171140 29495 24410 24412 EPHRIN SIGNALING%REACTOME%R-RNO-3928664.1 Ephrin signaling 306636 25186 24338 501203 83805 287989 29431 29433 25150 316369 114559 360546 363875 83841 KERATAN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 60%9438815 Keratan sulfate biosynthesis 83717 316583 65196 288752 313536 305571 362924 291015 84400 100911750 290638 64507 314771 363040 295934 290959 24390 64442 367145 494342 362275 303923 307859 64445 304023 81682 103690116 293667 HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME DATABASE ID RELEASE 60%9438781 HuR (ELAVL1) binds and stabilizes mRNA 25379 24680 85252 363854 170538 287437 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%R-RNO-170834.1 Signaling by TGF-beta Receptor Complex 500985 361831 25490 64156 304758 313477 59086 300947 29357 50522 365894 690516 310655 680111 114208 499929 297893 300813 307799 362110 81810 361509 287155 363445 84396 25631 81920 360801 315291 25639 54281 287607 100360427 361178 81918 25591 116651 297699 316742 29417 681260 311676 83837 500715 84576 29591 500695 641452 24790 295062 25522 103690035 116479 304193 297173 498837 100912032 SIGNALING BY HEDGEHOG%REACTOME%R-RNO-5358351.1 Signaling by Hedgehog 291983 287612 304832 307724 289711 289924 303968 50938 691171 25238 688749 113927 54223 302661 289990 291936 100362124 289712 360715 362549 140588 140589 58854 361769 503018 305509 29425 59320 64156 293047 312651 25273 304318 64508 289180 84420 287643 362265 308577 29699 24679 29675 50522 29671 29670 690516 24968 24967 25581 29666 29241 117263 117262 364814 290206 161475 83499 29614 689852 303353 681260 29668 292766 300084 365388 81827 498837 100912032 25387 25388 94198 29630 296651 408248 29499 314352 499241 25506 307821 289874 311324 362891 83806 287670 361765 85492 116643 29669 25521 25289 287716 25725 64532 293508 362356 25636 29677 683470 29672 302950 304729 295654 287772 364475 305918 305349 287280 89830 361438 287984 84392 311078 VLDL ASSEMBLY%REACTOME%R-RNO-8866423.1 VLDL assembly 25292 100910181 54225 680551 310900 25506 GLYCOSPHINGOLIPID METABOLISM%REACTOME%R-RNO-1660662.1 Glycosphingolipid metabolism 307404 83626 314360 294673 84431 29204 300129 303631 24591 50555 363494 103690047 298399 303790 362409 25227 25524 315222 316033 308909 24800 360800 296370 282838 114104 684536 303729 363120 288707 299488 64828 310508 94338 313771 316642 365619 83537 310326 300757 117185 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME DATABASE ID RELEASE 60%9439100 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 302935 94165 363849 294408 100911837 PRE-MRNA SPLICING%REACTOME%R-RNO-72163.1 pre-mRNA splicing 289561 103690054 245976 298508 364834 361365 292778 690966 362394 246216 117017 83503 289693 81781 287113 192246 361859 361522 103689936 680891 302879 298075 310687 100360750 300361 287530 689890 313035 287739 498109 363854 290647 100361574 361849 170933 292683 366163 494445 117280 500695 307410 687575 366952 681410 295270 297695 295334 681031 302557 688288 100359574 363633 100911462 311670 298095 85434 684148 306222 360613 140931 679890 365407 100363406 296913 114765 362829 315903 362153 362264 362361 100912534 298385 687679 287765 287768 500684 79256 89819 298374 304859 116697 303607 687711 80846 288701 316123 314417 308650 296320 361574 294232 680737 29678 293505 362152 295607 319110 171365 311166 81674 313449 299620 689116 361814 293671 64200 290614 685273 361995 29667 291877 307524 84486 60376 308335 366461 690303 117259 361887 366276 291794 292019 309338 294711 362223 498934 286973 295284 296126 100361269 100360682 291295 297455 361808 300996 362612 361605 313620 361542 362687 290666 292536 84401 309651 305479 102548514 683927 299256 245957 300092 317385 298916 304277 300208 297336 292007 117855 680309 292729 313583 689955 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%R-RNO-1234176.1 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 291983 289924 289990 361831 58854 307821 29425 64156 83806 287670 29675 50522 29671 29670 24968 25581 24967 29666 64345 308457 117263 117262 64525 81807 364814 81920 24874 290206 29560 54702 161475 85492 83499 29614 29669 689852 316101 361258 29452 303353 681260 287716 29668 292766 641452 29677 29672 300084 365388 81827 498837 287772 100912032 287984 311078 94198 29630 296651 408248 PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME DATABASE ID RELEASE 60%9439174 Phospholipase C-mediated cascade: FGFR1 54250 25443 25444 170579 25317 170583 29349 25738 29368 116499 60662 79114 170633 66017 170700 RUNX3 REGULATES WNT SIGNALING%REACTOME%R-RNO-8951430.1 RUNX3 regulates WNT signaling REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME%R-RNO-6806003.1 Regulation of TP53 Expression and Degradation 314856 304798 100910954 24185 681260 64156 81745 691318 56718 54237 117281 282844 295052 50522 24672 140926 115771 282845 24673 498837 315648 100912032 310131 103694903 29517 360471 114212 362817 296648 300711 311575 64226 114494 25405 MEIOTIC RECOMBINATION%REACTOME DATABASE ID RELEASE 60%9438835 Meiotic recombination 365155 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 60%9438194 Attachment of GPI anchor to uPAR 296360 316400 353304 50692 295543 303277 300046 103691942 PROTEIN UBIQUITINATION%REACTOME%R-RNO-8852135.1 Protein ubiquitination 100365043 304832 295274 297593 295686 100910200 313216 680403 100362554 293184 24829 100912338 298317 308282 361831 103690891 299602 305268 689226 296956 361247 300837 25737 64631 64156 103694506 100909787 297337 366169 306969 294331 64647 680312 498560 100909597 266712 287927 50522 116718 289623 293561 363445 81920 360471 681260 641452 684797 498837 680424 296368 100909445 83477 116725 100912032 100364835 307029 295568 306945 363065 117044 363064 29534 100359692 303478 292588 314432 362412 361531 312703 360847 291157 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 60%9438737 Passive transport by Aquaporins 65054 29171 25293 29170 25480 25241 25240 TRIGLYCERIDE METABOLISM%REACTOME%R-RNO-8979227.1 Triglyceride metabolism 140868 25598 252900 300108 25330 25062 24669 681211 25594 25629 363261 79223 24668 79131 80841 25440 293508 499570 316130 24360 29254 25404 29653 25636 313977 316737 64822 363471 84497 79451 362732 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-RNO-372708.1 p130Cas linkage to MAPK signaling for integrins 307171 116669 313494 24366 25661 361969 25414 24367 29302 685269 83805 295347 54245 25614 171337 ACTIVATION OF PKB%REACTOME%R-RNO-165158.1 Activation of PKB 25233 361992 81745 246273 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%R-RNO-2022870.1 Chondroitin sulfate biosynthesis 314694 316533 58982 25181 291577 292999 29139 286974 84468 50568 114122 500257 304322 25393 81651 296733 291770 306375 302302 297554 C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME DATABASE ID RELEASE 60%9438284 C-type lectin receptors (CLRs) 291983 303024 289924 25493 289990 308267 58854 29425 64156 296390 282817 24494 29675 50522 29671 29670 24968 24967 25581 29666 361509 117263 117262 364814 170538 309361 290206 309165 161475 84351 24703 83499 24244 29614 689852 83805 303353 681260 29668 81745 292766 365388 81827 498837 116725 100912032 29431 29433 24242 94198 29630 296651 408248 29748 361831 307821 29432 64044 24674 83806 117553 54244 314384 502902 360640 287670 64171 313121 288375 288378 363856 293621 360647 81678 311658 679539 100361818 100360982 501797 24605 100910732 361400 361765 315139 311245 85492 24525 100910771 25679 317546 25262 29669 100912618 287716 293508 362356 25636 29677 29672 81515 309452 287772 83477 287280 287984 311078 25150 309295 81736 LIPID PARTICLE ORGANIZATION%REACTOME DATABASE ID RELEASE 60%9439292 Lipid particle organization 305150 290223 311617 500292 ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 60%9438789 Activation of Na-permeable kainate receptors 29559 54257 ACTIVATION OF NMDA RECEPTOR AND POSTSYNAPTIC EVENTS%REACTOME DATABASE ID RELEASE 60%9438073 Activation of NMDA receptor and postsynaptic events 24245 24244 83613 116590 29629 81771 29627 24246 361568 29628 25050 317203 501560 305509 60341 24408 81745 29495 64508 293508 24410 24412 192213 293621 246150 117269 29241 25400 24242 100363500 291245 171140 81646 24703 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 60%9439208 Presynaptic phase of homologous DNA pairing and strand exchange 290805 64557 64046 497976 100362315 499870 363924 100361529 64012 116468 499966 303375 306734 685055 301014 291787 85482 288003 498411 294800 310034 497672 497856 308755 315969 360254 361836 304528 59102 287524 296883 288414 300711 LGI-ADAM INTERACTIONS%REACTOME%R-RNO-5682910.1 LGI-ADAM interactions 140729 306013 252892 116470 84347 301460 29495 361549 360638 24923 140724 140725 CHYLOMICRON REMODELING%REACTOME DATABASE ID RELEASE 60%9438342 Chylomicron remodeling 292697 24539 54225 25728 25649 300027 25081 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 60%9438809 Postsynaptic nicotinic acetylcholine receptors 170945 25102 25101 171131 25590 25302 65024 29422 81721 25103 54240 54239 79557 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 60%9437933 Purine salvage 25028 292072 24165 103689983 290029 25095 297389 311352 117533 362015 79127 192357 METABOLISM OF LIPIDS%REACTOME%R-RNO-556833.1 Metabolism of lipids 113965 307092 171516 498300 65984 294673 65030 296623 24306 287424 286896 79111 364380 24591 365410 24913 306490 113976 252898 365652 310155 83842 353498 366697 362360 293829 114554 266604 362261 29692 100363074 114561 500368 315673 65183 102556347 246074 316033 291793 499018 367786 301024 309855 309008 294255 360348 117543 58970 117243 84029 301120 296130 25284 84024 100911615 295631 117278 299193 363026 140607 170698 311341 25045 64310 58857 302640 364298 26759 680971 314438 29580 100188936 690388 140868 307855 290567 300083 293453 295417 296851 302705 25532 114097 171410 83724 25014 89841 500132 89842 65278 288322 25526 25429 365755 81681 25329 25527 116720 300095 366065 367308 25426 307170 25428 100910990 304474 58978 25427 287454 25413 366196 308309 310848 317456 25557 361467 171155 24157 170919 24159 314800 79238 50549 84578 84575 365865 359725 296732 287467 287366 293688 308100 171142 94197 117182 266674 25357 117035 116700 114089 24664 171400 25147 171402 363159 681361 302425 678749 314075 307641 25756 116549 81925 295305 83817 81924 246211 25757 363516 293620 360426 366984 85255 363067 298298 360833 29359 292658 80848 361993 294324 308584 308589 296138 288783 24950 29367 50557 293173 84013 84114 304500 503122 361802 24653 360843 296128 301118 291076 314824 305291 304208 25288 25287 291075 315422 29328 305166 301543 64669 309262 362702 25117 25747 301264 619549 296972 29230 170465 362809 307842 29347 25279 64369 360753 25271 100362555 503049 293150 140544 296188 140547 29354 24886 296048 25363 305816 24297 679520 25675 24298 691810 317576 170670 691813 309147 24294 84018 24158 361676 313375 363024 291211 681458 289733 314641 313373 291939 25290 679532 498741 289736 312634 310645 80849 170588 367112 287644 305419 85239 100360507 500892 85421 85238 291182 298579 59103 361659 362782 58962 362249 498962 298369 691905 25682 298423 310667 688517 29411 312086 24192 24197 282584 64304 29527 298947 29526 310773 499358 361631 297694 360521 313339 116699 690610 192242 24917 315173 316039 499174 84431 363494 65192 102549542 78968 500651 84497 681337 361694 100359680 313786 367808 690163 289322 308518 100910462 498728 291135 296091 361686 29500 94199 497991 361632 691018 100359675 364629 292097 24296 364764 246115 64677 29510 309419 362058 79242 303497 24230 305935 114100 114101 311849 363521 290623 362434 312828 79243 79244 140910 25227 56266 303698 362972 83522 83791 80899 83792 25524 286921 29632 499210 296461 100911154 363675 24693 89812 29743 29740 365962 362039 24384 679565 84608 361433 498331 306582 80900 311821 286936 689872 312947 502749 50572 100911186 362866 83512 29637 81650 365096 29189 289456 54398 64191 311129 25322 683381 84470 24777 29725 29194 81639 289021 29624 502348 100911581 100910957 116482 81727 313997 295674 286904 361401 313087 103689982 406165 287609 114700 317296 619561 313929 85311 290843 295458 192260 24450 305482 83569 680115 114209 361213 291283 679692 305684 293508 171088 94340 361413 316457 81726 25636 60431 315973 192270 114024 298504 687071 29726 306351 289125 192272 311865 50671 691478 116464 81747 306460 282838 309449 79122 116463 309527 25096 191576 191574 296474 497931 63865 497932 25511 300147 60666 60351 404280 313834 25097 50681 60664 64562 361992 363131 299732 305150 290223 311617 500292 54244 296370 25598 252900 300108 25330 25062 24669 681211 65052 25594 25629 363261 79223 24668 79131 80841 25440 499570 316130 315222 24360 25404 29653 313977 316737 64822 363471 79451 362732 78975 366508 360801 289014 287607 29741 85243 84509 29254 24624 25513 307404 83626 314360 29204 300129 303631 54259 50555 103690047 298399 303790 362409 308909 24800 360800 114104 684536 303729 363120 288707 299488 64828 310508 94338 313771 316642 365619 83537 310326 300757 117185 FORMATION OF THE CORNIFIED ENVELOPE%REACTOME DATABASE ID RELEASE 60%9439260 Formation of the cornified envelope 361319 100911681 302934 299587 307562 24332 100910851 498087 60335 291755 408215 81679 295190 291752 292949 303687 100910942 295625 310575 292848 100911797 288067 291760 408235 408214 306871 304822 307563 288075 293619 60583 291754 689230 308564 308562 100362978 308565 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME%R-RNO-8866910.1 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 24890 314993 25329 116700 VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME DATABASE ID RELEASE 60%9438250 VEGFR2 mediated cell proliferation 291983 171109 24514 246145 289924 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 58854 102552659 170668 29425 65179 24408 25167 64030 24716 24410 24412 117281 24446 498576 29675 29671 29670 29376 24968 24967 29372 690919 25704 112400 29666 24337 24329 117263 117262 116663 170538 364814 290206 24592 103694903 64022 161475 360814 24703 83499 24245 24244 25267 309179 29614 29496 295234 29211 689852 64363 24497 652957 116630 140924 114103 24246 303353 289257 84423 84422 29668 81745 29495 25614 292766 691318 25266 362572 360573 60427 24672 309168 365388 81827 24673 288924 171081 24242 94198 291245 296072 29630 81511 296651 408248 304893 24586 25746 116590 307821 50689 81678 83785 25023 25589 85492 83613 312754 300980 66023 25525 25326 314612 305203 312664 25136 432361 287716 114858 58960 192126 29542 192213 25467 192117 364052 246150 315648 305614 299147 288589 25400 25150 59323 25344 171140 84598 170577 59325 25433 25676 310533 64156 50522 25581 89807 89804 83805 24680 681260 64159 25522 498837 100912032 362045 56011 79114 81504 170633 83806 170700 313845 54250 287670 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 25114 25738 25022 29368 116499 60662 85385 170582 24525 66017 60464 25679 25262 29669 29677 29672 287772 287984 311078 CHYLOMICRON ASSEMBLY%REACTOME%R-RNO-8963888.1 Chylomicron assembly 292697 54225 25728 287276 310900 25506 25649 25081 UCH PROTEINASES%REACTOME%R-RNO-5689603.1 UCH proteinases 64557 291983 289924 289990 58854 500225 307821 29425 25490 64156 103692172 83806 498560 361107 287670 293494 363519 29675 50522 29671 29670 81822 24968 360853 24967 306257 25581 26295 29545 313922 315723 29666 65138 303753 117263 117262 364814 290206 300222 296084 161475 85492 315523 24919 83499 29614 29669 689852 303353 681260 287716 29668 292766 29677 29672 365388 81827 498837 287772 361925 100912032 287984 65137 311078 291737 94198 29630 296651 408248 316440 PROPIONYL-COA CATABOLISM%REACTOME%R-RNO-71032.1 Propionyl-CoA catabolism 24624 293829 688517 291939 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME DATABASE ID RELEASE 60%9438205 Transcription from mitochondrial promoters 299604 83474 289307 85261 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%R-RNO-193634.1 Axonal growth inhibition (RHOA activation) 24596 297173 83765 315691 450224 29409 360678 CHROMATIN ORGANIZATION%REACTOME%R-RNO-4839726.1 Chromatin organization 362093 360665 100365043 364382 295274 299557 291844 689883 317425 310194 100910200 691488 60421 680403 54282 316328 24829 89820 103694876 100912338 308345 114502 362594 297597 29520 361247 100911617 83833 306969 94201 685179 64647 680312 295384 100911453 444984 363519 306254 290925 288563 315959 83712 306571 26295 296501 310352 81647 361825 304061 297867 689820 363292 303518 282546 303470 303514 363002 312800 309165 309790 300222 310769 361745 58919 102551184 361688 311575 301020 29512 366980 171379 680097 83724 295277 100912489 313929 364723 291159 102548682 100360950 500351 679983 309452 684797 691496 361925 102557184 29511 100364835 296732 306945 100359692 81736 291157 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME%R-RNO-1237044.1 Erythrocytes take up carbon dioxide and release oxygen 103694857 689064 25240 287167 365345 100134871 54231 310218 361619 25632 65207 24779 304805 689035 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 60%9438344 Activation of ATR in response to replication stress 363924 100361529 116468 685055 301014 288003 498411 294800 310034 360908 362304 301430 316273 298534 304528 295596 59102 313138 296178 29728 287524 291927 307126 360621 312538 287961 313479 29685 291885 288532 296883 288414 362817 PTK6 PROMOTES HIF1A STABILIZATION%REACTOME DATABASE ID RELEASE 60%9439294 PTK6 promotes HIF1A stabilization 24329 366275 300160 113955 29560 25433 REGULATION OF SIGNALING BY CBL%REACTOME%R-RNO-912631.1 Regulation of signaling by CBL 63881 366508 81515 500985 25734 85243 25150 287942 54245 81504 25513 100911248 25156 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME DATABASE ID RELEASE 60%9438264 TRAF6 mediated NF-kB activation 81722 287707 309452 25493 301059 309295 309361 309165 81736 84351 25742 305751 81525 304859 54226 SIGNALING BY ERBB4%REACTOME DATABASE ID RELEASE 60%9438894 Signaling by ERBB4 29496 24918 681260 432361 64156 81504 25513 313845 50522 293621 498837 690919 112400 100912032 289231 24605 24890 24329 363014 100911293 59323 300802 85385 691658 81751 64022 365872 297930 59325 292788 25433 24525 SYNTHESIS OF PE%REACTOME%R-RNO-1483213.1 Synthesis of PE 681361 316737 310773 687071 360843 287644 362261 29194 312828 89841 29367 313977 PHOSPHOLIPID METABOLISM%REACTOME%R-RNO-1483257.1 Phospholipid metabolism 366508 317576 691810 296623 170670 691813 84018 361676 364380 363024 24913 306490 289733 314641 310155 498741 312634 80849 114554 287644 362261 305419 29692 114561 315673 85238 298579 361659 291793 362249 367786 691905 309855 309008 294255 296130 24197 282584 100911615 295631 298947 29526 310773 140607 311341 297694 360521 64310 287607 116699 364298 690610 680971 316039 690388 290567 29741 295417 85243 25532 89841 500132 288322 116720 367308 29254 363131 304474 100910990 366196 308309 317456 84497 361467 171155 170919 361694 100359680 365865 287467 296091 287366 361686 94197 361632 100359675 364629 114089 29510 309419 362058 305935 114101 363521 362434 312828 363159 681361 303698 302425 362972 678749 314075 307641 116549 81925 25513 295305 83817 89812 362039 365962 361433 498331 306582 286936 311821 502749 362866 81650 84470 29194 289021 293620 116482 360426 313997 295674 361401 103689982 313087 29359 406165 294324 252900 308584 317296 54259 85311 290843 29367 50557 192260 65052 305482 24653 360843 296128 679692 171088 314824 316457 29653 313977 315422 305166 316737 298504 687071 362702 691478 81747 306460 307842 25096 360753 497931 497932 293150 25511 140544 300147 60666 29354 296048 25097 305816 60664 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 60%9438385 FGFR2 ligand binding and activation 54250 25443 25444 170579 25317 170583 29348 29349 25022 64535 29368 116499 60662 170633 66017 170700 60464 REGULATION OF THYROID HORMONE ACTIVITY%REACTOME DATABASE ID RELEASE 60%9438520 Regulation of thyroid hormone activity INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 60%9438831 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate 362474 314196 301624 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME%R-RNO-73933.1 Resolution of Abasic Sites (AP sites) 29240 362600 315344 116468 29541 308576 114521 288003 367090 81528 83507 84490 680915 304577 24561 79116 303369 170841 25737 304528 289758 59102 59294 287524 361698 89809 296883 84495 288414 25591 81513 100911727 PROCESSING AND ACTIVATION OF SUMO%REACTOME DATABASE ID RELEASE 60%9439064 Processing and activation of SUMO 303874 25573 103689978 308384 301442 78973 499417 65026 300193 308508 679900 MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 60%9439236 Major pathway of rRNA processing in the nucleolus and cytosol 64156 100360057 367195 100360619 100911847 81729 100359574 114021 290556 309628 688637 316317 317399 289740 310720 289810 314713 300050 100360664 314545 313744 313167 103689953 103692785 309301 293828 361977 287417 85432 360572 100912375 292964 363134 367865 362967 103690821 362703 291987 362902 299198 305258 287120 288647 303245 360574 367265 100910180 25135 360828 100911575 679140 140662 313581 300045 313243 100364265 313707 295050 100360841 363237 294975 303456 362229 298065 366017 305076 140661 314617 361159 64640 309458 316098 29283 297685 308441 690297 29284 317579 103692831 289724 28298 362214 686999 26962 361262 64302 296865 60373 103693375 290660 290641 312706 689284 365668 362041 314830 292747 100360117 296709 103694404 317646 81767 29282 81763 100360522 81768 81765 81769 64205 311120 301299 100362830 300092 690468 314652 81770 64638 306079 103694169 315697 310019 100912182 300079 25347 682793 100910370 685963 124440 306926 29258 100359922 65043 499782 100361079 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 60%9438982 Synthesis of IP3 and IP4 in the cytosol 497197 29322 313756 24244 25031 54260 24654 317576 140693 362590 54259 50557 500709 25738 310463 81677 362792 24242 308451 287745 24655 114633 171088 85238 METABOLISM OF VITAMIN K%REACTOME%R-RNO-6806664.1 Metabolism of vitamin K 309004 313706 COLLAGEN DEGRADATION%REACTOME DATABASE ID RELEASE 60%9438935 Collagen degradation 102554637 408247 63849 683849 64529 81687 24691 171293 171052 81707 103690254 25052 117061 85251 117033 103690164 25335 315388 100169747 300339 81686 367236 685612 499431 300341 29175 291848 54281 362347 OVARIAN TUMOR DOMAIN PROTEASES%REACTOME%R-RNO-5689896.1 Ovarian tumor domain proteases 100910954 683206 361831 50557 681260 64156 291912 54237 50522 297173 500133 498837 100912032 306886 24890 293705 305451 500572 309295 363982 100360606 362491 311245 24205 116643 315911 286761 363599 362788 310677 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME%R-RNO-5358565.1 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 296883 59294 25737 100360342 81685 287524 81709 289758 361698 59102 81513 100911727 METABOLISM OF STEROID HORMONES%REACTOME DATABASE ID RELEASE 60%9438418 Metabolism of steroid hormones 24298 24230 24294 287609 24950 79243 353498 25329 286921 29632 100911154 305291 363675 500892 291182 25557 25117 360348 296972 313786 24192 79122 100910462 116463 29189 289456 25322 117182 691018 116700 24664 64677 25147 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 60%9438242 MyD88 cascade initiated on plasma membrane 303024 116590 25493 689314 363855 314322 81771 308267 363520 64156 291912 498003 296390 50689 25272 117281 314384 313121 287398 50522 500133 100912585 679539 315305 305549 114509 81647 301059 81649 362418 305451 305835 116663 100363500 309361 361765 289014 81646 103694903 309165 315139 311245 84351 114495 100910771 317546 50658 361565 300980 300447 100912399 116596 116667 303200 315994 100912618 681260 501560 116554 24516 362356 81722 287707 24672 309452 24673 498837 315648 117269 116725 100912032 287280 309295 81736 362491 25742 60587 305751 309957 81525 304859 54226 MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 60%9438068 Mitochondrial biogenesis 361596 24244 306840 83474 24787 311569 304539 363735 293615 499883 24399 25309 25050 24242 100363500 81646 100363502 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-RNO-77075.1 RNA Pol II CTD phosphorylation and interaction with CE 171150 289561 294693 316123 103690054 364834 361365 81674 498109 100361574 291534 84389 313131 292778 690966 308472 308415 288651 363633 502227 266713 117017 100912534 83503 294236 361580 291703 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 60%9438672 G alpha (z) signalling events 24400 25686 302950 54223 29241 24175 25740 25289 305509 25083 64532 64508 84420 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME%R-RNO-77289.1 Mitochondrial Fatty Acid Beta-Oxidation 113965 293453 170670 361993 24158 619561 291939 24624 361992 304500 293829 100363074 25287 29740 315973 289125 171155 192272 117543 688517 100911186 170465 64304 291135 503049 25045 302640 140547 26759 315173 25363 29510 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 60%9437978 RNA Polymerase III Transcription 691501 316810 498109 361102 100361574 690966 685465 294687 306542 690254 306012 246299 299347 362537 362858 685539 117526 310685 311487 300088 83503 100912534 361640 171068 366277 171063 301246 304204 362095 362088 361858 REGULATION OF IFNG SIGNALING%REACTOME DATABASE ID RELEASE 60%9438826 Regulation of IFNG signaling 24514 25712 84598 360697 367264 117063 25124 89829 300772 301442 252971 116465 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME DATABASE ID RELEASE 60%9439030 Binding and Uptake of Ligands by Scavenger Receptors 54225 100365047 103694857 287167 25728 300060 64023 58917 315108 361619 25632 64202 25377 361289 24791 367391 312701 498854 366588 362862 503164 689064 299858 282580 29184 498638 499985 103690020 25073 100134871 25081 DIGESTION%REACTOME DATABASE ID RELEASE 60%9438415 Digestion 363465 25680 64055 25656 100359675 367308 25711 25702 24197 ACYL CHAIN REMODELLING OF PG%REACTOME DATABASE ID RELEASE 60%9438943 Acyl chain remodelling of PG 362039 690388 366196 317456 29359 691905 361467 289733 295631 29526 24653 311341 679692 29692 29354 296048 298579 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME DATABASE ID RELEASE 60%9438336 Processive synthesis on the C-strand of the telomere 296883 59294 25737 287524 289758 361698 84490 59102 81513 361836 100911727 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 60%9438222 Toll-Like Receptors Cascades 303024 305354 54225 305353 25493 317468 689314 29260 684440 680127 364594 363855 292892 314322 685174 81771 310461 308267 363520 361689 246116 64156 314764 312562 498003 296390 25272 117281 287398 50522 362862 100912585 315305 305549 114509 81647 301059 499985 305451 103690020 116663 309361 289014 81646 103694903 309165 84351 364867 338457 681260 363131 81722 287707 24672 24673 498837 116725 100912032 25021 296321 25742 305751 81525 54226 304859 100365047 116590 310553 291912 64350 64529 29469 50689 314384 313121 500133 679539 29184 81649 362418 305835 100363500 361765 309684 315139 311245 114495 100910771 317546 60350 50658 300980 361565 300447 100912399 116667 116596 303200 315994 65052 100912618 501560 116554 24516 362356 300177 309452 315648 117269 287280 309295 63865 29175 81736 362491 60587 309957 REUPTAKE OF GABA%REACTOME%R-RNO-888593.1 Reuptake of GABA 79213 79212 50676 171163 CLEAVAGE OF THE DAMAGED PURINE%REACTOME DATABASE ID RELEASE 60%9438037 Cleavage of the damaged purine 81528 24561 170841 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-RNO-75892.1 Platelet Adhesion to exposed collagen 691992 116669 100911551 25150 116727 81515 502858 25259 25441 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 60%9437824 Carbohydrate metabolism 100364062 64076 294673 25659 25552 170580 24782 290959 117281 316033 501103 282580 292804 24191 25139 25658 103694903 24778 24203 24244 84406 114005 116673 114002 361730 24849 306866 684314 58920 117267 293722 246136 117276 25592 24528 311215 362383 287115 364675 100911625 171517 299907 24190 64468 302489 364682 501157 367166 691394 24401 170943 303218 295443 64152 361378 171408 114860 116569 360630 24672 363618 303565 54283 295352 24673 295351 103690051 290277 25216 691984 497756 25059 360904 24651 287835 25351 25438 684979 24189 100911725 24390 287479 24242 293451 24640 24788 24644 297865 303205 65152 295245 78959 690987 113901 66020 24771 24638 315722 362706 289608 296973 24377 25623 114508 60416 81829 24959 282821 294103 497039 298003 25615 24362 25721 24551 25741 361450 266805 309513 290636 58982 289827 25181 294449 29633 291577 64544 292999 64134 29139 308797 286974 292155 84468 293186 50568 298690 114122 362282 500257 365583 304322 317322 25393 24333 81651 316067 296733 24334 291770 29562 306375 246255 302302 316325 297554 64201 314694 316533 315648 64537 64156 299052 64035 50522 24192 53372 294429 83717 300259 316583 65196 299706 288752 313536 305571 65197 292085 362924 117021 291015 84400 304862 100911750 290638 64507 314771 363040 58958 245922 295934 113929 65274 367562 681260 287830 116555 362281 25281 683983 295692 291874 81738 499974 113975 498837 100912032 25497 362335 116721 64442 25406 367145 494342 362275 303923 307859 64445 304023 81682 103690116 293667 690945 294321 25227 29353 362029 140671 25634 64561 685076 29743 24645 24701 25104 361377 25630 304785 289032 500973 83688 310864 64524 81675 25636 24385 100362738 24434 289632 300757 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 60%9438651 Beta-oxidation of very long chain fatty acids 363516 299193 171142 170588 311849 681337 24157 291076 85239 50681 79244 291075 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME%R-RNO-76042.1 RNA Polymerase II Transcription Initiation And Promoter Clearance 116550 171150 103695118 288533 289561 294693 81673 291773 682902 316123 294018 83828 293345 103690054 310784 171152 100360100 364834 306516 361365 303918 83830 498109 81674 100361574 84389 292778 690966 307485 170844 308415 288651 363633 502227 266713 117017 117526 83503 100912534 294236 361580 291703 ER-PHAGOSOME PATHWAY%REACTOME DATABASE ID RELEASE 60%9439298 ER-Phagosome pathway 310710 24812 24811 64202 25217 103689996 81803 MYD88-INDEPENDENT TLR3 TLR4 CASCADE%REACTOME%R-RNO-166166.1 MyD88-independent TLR3 TLR4 cascade 303024 116590 25493 689314 363855 314322 292892 81771 308267 363520 64156 291912 498003 296390 50689 25272 117281 314384 313121 287398 50522 500133 100912585 679539 315305 114509 81647 301059 81649 362418 305451 116663 100363500 309361 361765 289014 81646 103694903 309165 315139 311245 84351 114495 100910771 317546 50658 361565 300980 116596 303200 315994 100912618 681260 501560 116554 24516 362356 81722 287707 24672 309452 24673 498837 315648 117269 116725 100912032 287280 309295 81736 362491 25742 60587 305751 309957 81525 304859 54226 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%R-RNO-2559580.1 Oxidative Stress Induced Senescence 314856 304798 114483 100910954 116590 689314 363855 310511 314322 64156 94201 25272 50689 54238 25164 287398 50522 83712 81649 289014 102551184 114495 100360868 680097 50658 295277 100912489 303200 117056 364723 315994 681260 103693372 291159 102548682 116554 24516 100360950 500351 313038 365057 679983 315136 498837 691496 102557184 100912032 362581 309626 304850 293104 312299 303730 303731 116484 501403 498183 310258 313048 303259 363630 307151 312690 NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 60%9438850 Negative regulation of FGFR3 signaling 116590 500985 306141 500526 83805 681260 64156 81504 50689 117281 54250 25444 50522 24672 24673 314850 498837 25317 170583 29349 84489 100912032 29368 116499 25622 60662 103694903 66017 60464 AURKA ACTIVATION BY TPX2%REACTOME DATABASE ID RELEASE 60%9439285 AURKA Activation by TPX2 29753 304740 302661 114482 29214 308064 305467 683722 56010 252921 299331 117281 24679 680991 691918 362504 361634 29167 680477 305909 305882 29479 64462 293844 100911033 300963 363055 311546 83572 81740 315423 367153 116659 500069 291540 294010 690209 311191 192228 64158 299850 316531 309692 296554 100362495 311529 305288 311802 311573 54237 286919 360672 299730 58822 310344 83836 103690034 261730 290626 305002 246150 114764 311886 29213 60347 84593 INTERFERON GAMMA SIGNALING%REACTOME DATABASE ID RELEASE 60%9438823 Interferon gamma signaling 24245 24514 360697 25124 117063 301442 300772 89829 252971 116465 24246 25400 170538 25712 116689 171140 84598 367264 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%R-RNO-442717.1 CREB phosphorylation through the activation of CaMKK 24244 25050 24242 100363500 60341 81646 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%R-RNO-114452.1 Activation of BH3-only proteins 29748 64547 492821 246142 313017 29753 25576 64625 298795 56011 56010 64639 140734 24224 25577 171378 116554 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 60%9437793 Cyclin E associated events during G1 S transition 291983 24708 171150 362485 114851 83571 25729 289924 289990 58854 307821 84389 29425 64156 94201 171102 499655 83806 294790 308937 287670 29675 295052 50522 29671 29670 24968 25581 24967 29666 117263 117262 362817 161475 85492 58919 114494 83499 24185 29614 29669 689852 303353 681260 287716 29668 292766 362356 29677 29672 365388 81827 498837 266713 287772 100912032 287280 287984 366275 311078 94198 29630 296651 408248 HYPUSINYLATION%REACTOME DATABASE ID RELEASE 60%9438516 Hypusinylation 287444 314644 288923 310261 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 60%9438904 PI3K events in ERBB2 signaling 29496 690919 112400 361388 24337 24329 432361 102552659 59323 81504 64022 25513 59325 25433 POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME DATABASE ID RELEASE 60%9438717 Post-transcriptional silencing by small RNAs 298533 313593 308971 313594 59117 192178 303774 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 60%9438591 Interaction between L1 and Ankyrins 289257 116690 29686 245956 50687 29211 306570 64159 305614 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%R-RNO-174048.1 APC C:Cdc20 mediated degradation of Cyclin B 25203 290875 361389 64515 50522 498837 296558 296368 291689 360643 366381 311412 498030 100360936 361831 100912032 304490 305420 293155 681260 64156 54237 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME DATABASE ID RELEASE 60%9438280 Beta-catenin independent WNT signaling 291983 81637 64558 29748 65046 24400 289924 50664 289990 365901 266715 314212 58854 24881 307821 58868 29425 64156 24674 83806 497961 287670 29675 313121 140584 50522 289878 29671 100360552 29670 690516 161452 81678 24968 306782 24967 24681 25581 100361818 64512 688297 116561 282581 307799 307401 29666 64303 315259 117263 117262 364814 116563 83800 290206 25023 85492 161475 363875 303251 83499 24244 100910771 25679 29614 25262 29669 689852 303353 24680 681260 287716 29668 292766 29322 29677 308578 29672 24654 297173 365388 81827 498837 140670 287772 100912032 287984 25400 311078 64566 25388 24242 94198 29630 54241 296651 408248 COHESIN LOADING ONTO CHROMATIN%REACTOME DATABASE ID RELEASE 60%9439050 Cohesin Loading onto Chromatin 304218 314949 63996 290577 29486 305343 313304 315958 290668 AMINO ACID CONJUGATION%REACTOME%R-RNO-156587.1 Amino Acid conjugation 246263 293779 361638 LIGAND-GATED ION CHANNEL TRANSPORT%REACTOME%R-RNO-975298.1 Ligand-gated ion channel transport 140675 58963 29695 79246 25451 29705 289606 29694 192258 25456 25450 29708 65187 29709 29707 25674 24947 DSCAM INTERACTIONS%REACTOME%R-RNO-376172.1 DSCAM interactions 171119 29431 29513 81649 60352 315615 689314 116554 363875 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME DATABASE ID RELEASE 60%9438502 Generation of second messenger molecules 309621 25300 363577 315609 309622 24932 100910732 25738 29431 25710 29433 294269 499537 81511 300955 100910488 29432 688090 155918 24981 317371 300678 294270 310727 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 60%9438628 IRE1alpha activates chaperones 298068 288919 361273 309858 498013 80881 689134 80843 294912 ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-RNO-111448.1 Activation of NOXA and translocation to mitochondria 492821 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%R-RNO-2404192.1 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 291983 26954 171109 24514 246145 289924 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 58854 102552659 170668 29425 65179 24408 25167 64030 64562 287871 24716 24410 24412 56718 117281 24446 301518 498576 29675 298514 29671 29670 29376 24968 24967 29372 690919 25704 112400 29666 24337 24329 117263 117262 116663 364814 290206 24592 103694903 246273 64022 161475 308869 60445 360814 24703 64226 83499 24245 24244 338457 25267 309179 29614 29496 295234 29211 689852 64363 24497 652957 116630 140924 114103 24246 303353 24855 289257 84423 361992 84422 29668 81745 303605 29495 25614 292766 691318 25266 363131 362572 310091 360573 60427 24672 309168 365388 81827 24673 24482 292887 288924 171081 24242 291245 94198 296072 29630 81511 296651 408248 297960 304893 24483 24586 25746 301574 116590 307821 50689 100912571 116636 85492 25233 300253 83613 290291 312754 83803 24185 29516 65248 300980 66023 25525 25326 360776 314612 305203 312664 25136 65052 432361 287716 114858 58960 501146 192126 29542 192213 83840 25467 192117 295357 364052 246150 315648 117045 305614 299147 78975 288589 25400 25150 100909655 117044 59323 25344 171140 84598 170577 117043 59325 25433 25435 25676 310533 64156 50522 25581 89807 29741 89804 85243 83805 681260 64159 100361543 498837 100912032 315761 362045 56011 79114 81504 170633 25513 83806 170700 313845 287670 54250 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 361388 25114 25022 29368 116499 25622 60662 85385 170582 24525 66017 60464 29669 29677 29672 287772 287984 311078 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 60%9438050 Opioid Signalling 29748 24400 116590 50664 25238 25686 54223 81664 25643 365901 363143 25050 25740 305509 64508 84420 24674 286924 117281 29699 24679 25031 81678 24681 29241 100363500 170538 81646 103694903 24244 25679 25262 25521 24680 25289 25725 24653 24668 64532 293508 25636 29322 29749 25601 25638 29691 24654 24672 24611 360616 24626 24673 290646 302950 315648 24242 24627 29190 24675 140908 24664 THE NLRP3 INFLAMMASOME%REACTOME%R-RNO-844456.1 The NLRP3 inflammasome 287362 29665 117514 301252 116484 300732 282817 290408 58923 315435 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 60%9437873 Tryptophan catabolism 50719 29416 311844 171385 66029 59113 116682 64206 315439 AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME DATABASE ID RELEASE 60%9438140 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 680006 297176 CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME DATABASE ID RELEASE 60%9438176 Conjugation of salicylate with glycine 293779 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME DATABASE ID RELEASE 60%9438334 Telomere C-strand synthesis initiation 100362333 299112 304573 85242 301323 246327 DUAL INCISION IN GG-NER%REACTOME%R-RNO-5696400.1 Dual Incision in GG-NER 361181 294693 116468 288003 681260 25737 64156 304528 289758 301382 59102 64470 308415 288651 292673 59294 50522 300084 310707 287524 502227 498837 361698 100912032 89809 100362121 296883 298074 294236 302502 288414 361580 25591 291703 LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 60%9438228 Lectin pathway of complement activation 114091 100911854 64668 366588 64023 299928 64459 G1 PHASE%REACTOME DATABASE ID RELEASE 60%9437795 G1 Phase 24708 171150 114483 114851 83571 24514 399489 100909750 311562 682033 291105 117104 83805 681260 84389 311860 64156 81758 684111 94201 362356 499655 294790 54238 25164 117281 300947 81515 24672 50522 24673 680111 498837 266713 315648 287280 100912032 366275 103694903 100360427 361178 58919 116651 INOSITOL PHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 60%9438983 Inositol phosphate metabolism 24244 317576 54259 50557 311355 500709 29688 310463 81677 680248 362792 365382 688862 308451 80849 287745 24655 114633 306808 499878 294292 171088 290651 171458 316376 85238 59268 50560 94267 29322 497197 313756 25031 54260 24654 367747 282636 140693 83523 362590 501194 25738 24242 116699 GAP JUNCTION DEGRADATION%REACTOME%R-RNO-190873.1 Gap junction degradation 315840 116563 83800 140694 25751 79128 116561 24392 ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 60%9438312 Alternative complement activation 294257 24232 54249 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%R-RNO-456926.1 Thrombin signalling through proteinase activated receptors (PARs) 89788 81662 116498 24400 116590 81666 309242 29251 25439 29636 25387 83805 303634 25388 50689 81663 SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME DATABASE ID RELEASE 60%9439110 SUMOylation of DNA replication proteins 300259 299706 292085 117021 304862 301442 58958 245922 113929 65274 25737 287830 25573 116555 362281 25281 683983 295692 291874 81738 499974 113975 500545 114592 362965 293733 25497 362335 362827 83614 64550 499179 64041 499417 53372 294429 SCAVENGING BY CLASS B RECEPTORS%REACTOME DATABASE ID RELEASE 60%9439034 Scavenging by Class B Receptors 499985 54225 100365047 103690020 25073 25081 29184 INTERACTIONS OF NEUREXINS AND NEUROLIGINS AT SYNAPSES%REACTOME%R-RNO-6794361.1 Interactions of neurexins and neuroligins at synapses 64053 500219 64353 313052 304733 83589 116470 171297 59312 679668 83610 78957 65040 286930 117096 116724 309557 103690160 60377 29647 25558 24409 116647 246212 60391 29495 24410 83527 685472 286923 294380 116681 24414 29548 116595 79146 29547 58948 29546 81859 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%R-RNO-199220.1 Vitamin B5 (pantothenate) metabolism 170551 302422 50671 363069 296167 300328 103689921 29142 298490 294088 287711 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 60%9438454 CD28 dependent PI3K Akt signaling 25408 360640 25660 24185 116596 25150 310131 361992 81745 246273 25513 296648 56822 64226 56718 RECYCLING OF BILE ACIDS AND SALTS%REACTOME DATABASE ID RELEASE 60%9438170 Recycling of bile acids and salts 84608 80900 79111 50572 83724 313929 83569 29500 25271 80899 170698 24777 29725 25440 60351 502348 58978 REGULATION BY C-FLIP%REACTOME%R-RNO-3371378.1 Regulation by c-FLIP 306886 266610 246775 25385 246097 117279 311786 246756 64044 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%R-RNO-442729.1 CREB phosphorylation through the activation of CaMKII 24245 24244 83613 246150 24246 25400 24242 100363500 291245 24408 81646 171140 29495 24410 24412 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%R-RNO-1474244.1 Extracellular matrix organization 304802 297894 313662 25304 25473 289081 252835 24628 304608 84032 25567 59107 54266 25697 100911363 305104 683849 294297 306628 304135 316313 25464 25412 83727 83838 100909977 362429 25353 679837 293677 312115 315744 29154 313785 171293 117036 57025 24791 114517 292734 60379 83577 81008 29393 499271 192362 300901 287899 315191 64315 81634 309460 25043 305078 364786 315174 678743 102553715 360526 25312 24914 305253 25048 445442 294279 116552 310683 282583 298941 24617 85253 25361 353303 287382 304021 363265 288583 298101 302248 499285 29569 64204 25717 63849 25592 29268 309816 311061 85250 361612 102555086 313592 362285 25713 25296 29543 25494 83470 315071 365460 309837 294027 29373 25266 25481 301012 292852 363457 29153 363158 84352 306404 287299 25627 25118 25216 85490 290905 24477 103689932 25254 85272 29345 81809 290637 303068 362800 100911572 315509 311716 362584 29169 25724 64367 65205 24771 315714 314981 83502 64350 24856 64529 25615 360647 58982 25181 29139 114122 25589 25393 24366 25661 361969 24367 29302 685269 299606 308995 29364 25052 59086 54281 24680 116479 103690254 25021 25406 362347 81682 408247 25506 81687 54250 290257 309684 102554637 29647 60391 24691 171052 81707 117061 85251 117033 25246 100911545 103690164 25335 25654 315388 366474 307582 100169747 300339 316758 360606 81686 64475 367236 311144 296358 66015 100911730 685612 24291 499431 300341 305604 25678 29175 114489 291848 140433 24153 298702 54271 25403 116510 29156 29158 TRP CHANNELS%REACTOME%R-RNO-3295583.1 TRP channels 89821 293874 89823 361586 171384 282822 116469 60395 308022 497948 140933 309407 84494 294329 114246 292168 66026 365391 288371 362247 312896 83810 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 60%9437927 RNA Polymerase II Pre-transcription Events 303132 116550 171150 266787 304832 103695118 289561 288533 301119 294693 81673 311796 291773 25562 682902 316123 294018 305851 83828 294258 287608 103690054 293345 293184 310784 306261 171152 306347 100360100 81785 364834 305455 306516 361365 303918 303281 83830 291705 81674 300837 84389 292778 689116 690966 366169 307485 170844 304758 308415 288651 502227 362110 117017 117526 64525 81807 83503 315291 291703 298075 362479 498109 100361574 500715 308472 363633 266713 363064 100912534 294236 498453 361531 361580 RHO GTPASE EFFECTORS%REACTOME%R-RNO-195258.1 RHO GTPase Effectors 117281 103694903 308875 24244 309179 83724 81745 29495 25614 691318 363131 24672 24673 297176 24242 116590 308666 360854 83502 29432 50689 301701 298594 304813 286993 308443 100911204 293860 362548 308761 297383 311793 302976 681050 317252 500904 100910732 308516 684439 100910474 294712 304951 304477 363875 293660 684969 360620 298850 501706 287598 312754 58823 363028 363174 100909840 691493 289150 305270 292279 83572 360564 81531 361416 100911597 85428 24669 315164 65052 25594 295661 102551071 313024 311191 296313 315151 291441 681185 79115 287876 300030 25448 500569 65172 316425 301009 296137 309774 103692165 257649 679934 83836 79249 114243 685867 257644 29355 308572 315648 114764 83620 303073 299147 362816 207122 116670 29648 114004 498310 114514 311327 306464 54227 117542 100361457 303037 114553 690538 685883 307511 117538 288669 682507 304740 314212 499933 81822 64303 81732 102551184 303251 294429 299706 100360868 680097 292085 295277 100912489 117056 364723 64373 83805 85252 103693372 287830 300955 102548682 366957 116555 317371 100360950 683983 500351 81738 679983 25537 297518 102557184 29431 29433 315348 171576 64515 680006 313017 100909750 29753 25576 307483 298795 66021 56011 56010 361662 25577 311860 81504 500545 114592 362965 293733 64041 65201 310621 361598 307505 362044 309159 171529 287624 29417 64465 60377 291159 289820 81762 297173 691496 79129 170845 314906 24582 307805 361029 288057 25745 84391 362186 100909726 360886 297522 304447 259242 25744 501099 363059 BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME%R-RNO-5620922.1 BBSome-mediated cargo-targeting to cilium 363760 171044 299246 362142 361930 315484 316102 300754 309156 113948 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 60%9438053 Ca-dependent events 24244 116590 25238 54223 25521 24680 25050 25289 25725 305509 24653 64532 293508 64508 84420 25636 29699 24679 29691 302950 24681 29241 170538 100363500 24242 81646 NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME DATABASE ID RELEASE 60%9439204 Negative feedback regulation of MAPK pathway 58960 116590 50689 24703 SHC-MEDIATED CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 60%9439181 SHC-mediated cascade:FGFR4 313845 54250 25444 293621 25317 170583 29349 24605 25114 29368 116499 85385 170582 81504 24525 66017 170700 60464 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 60%9437900 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 300253 296302 29288 288599 140655 362952 681260 100362830 292148 81775 293427 29752 81776 292762 299027 25348 100912571 300069 294282 293484 116636 288516 29236 65139 100360647 297756 498837 103690015 684988 298700 100912032 691531 117045 295975 299872 29284 691947 100911847 687780 287436 29258 100360679 54318 100911110 161477 302697 25538 303831 LYSOSOMAL GLYCOGEN CATABOLISM%REACTOME DATABASE ID RELEASE 60%9439127 Lysosomal glycogen catabolism 367562 81675 REPRODUCTION%REACTOME%R-RNO-1474165.1 Reproduction 24936 500052 680912 366174 290989 24163 304485 499152 362623 METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME DATABASE ID RELEASE 60%9438184 Metabolism of fat-soluble vitamins 307092 54225 171516 116673 58920 25592 292697 25680 24539 25728 171517 286921 291283 24856 25702 25649 300027 309004 362757 25615 24710 313706 315644 25056 25216 362558 691984 25703 296972 55939 64047 299858 114106 25571 116463 191574 317322 24771 25081 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 60%9438513 Class I MHC mediated antigen processing & presentation 291983 303024 289924 289990 298317 305268 58854 29425 64156 294790 64202 81803 29675 50522 29671 29670 24968 25581 24967 29666 499985 117263 117262 103690020 364814 290206 161475 83499 29614 689852 303353 681260 29668 292766 300084 365388 81827 498837 312647 100912032 94198 29630 296651 408248 100365047 66021 295461 100910646 300968 362900 307821 308968 100359528 288921 313722 362376 310710 80897 24812 24811 140941 366854 83806 310363 117553 25217 303336 103689996 363083 287670 100360914 300849 306825 317241 171043 500587 311373 690769 81815 93646 85273 308283 678726 301674 500904 29184 364681 306129 50558 311881 313782 313101 287276 292757 361765 498089 287275 303215 362367 85492 287552 140593 498941 300724 117524 310843 100125363 309444 362002 291597 362081 361907 362277 502852 29669 363188 498959 362511 64517 301015 302987 312504 305424 301000 313806 494223 308999 287716 60383 685144 360818 363790 304522 58817 361354 309453 362356 316575 308901 295279 192351 29677 29672 287772 287280 79129 287984 311078 297522 314432 114553 24223 APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-RNO-5649702.1 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 29240 84495 308576 367090 81528 303369 TP53 REGULATES METABOLIC GENES%REACTOME DATABASE ID RELEASE 60%9437835 TP53 Regulates Metabolic Genes 294518 26954 362045 83803 502894 24185 58819 117254 140942 295234 65248 313017 29753 25576 360776 298795 56011 56010 24855 24377 25577 64562 287871 502988 116686 56718 310091 100361543 301518 298514 295357 292804 78975 100909655 117044 116484 117043 60445 308869 297960 64226 GALACTOSE CATABOLISM%REACTOME DATABASE ID RELEASE 60%9437833 Galactose catabolism 114860 298003 289632 685076 24645 287835 GPCR DOWNSTREAM SIGNALING%REACTOME DATABASE ID RELEASE 60%9438101 GPCR downstream signaling 103693566 64636 293262 25360 366844 366843 308163 25369 366816 100124593 246254 691774 296037 366109 366103 293268 246219 100912408 29238 25111 293091 293289 25380 81821 117027 25726 25723 24889 293255 25370 360750 500927 293083 293271 292794 293278 360579 54305 294138 293281 29234 293085 293285 688730 301066 497196 293279 29237 690572 170538 25107 287910 308875 684170 25593 293435 295834 24419 287322 684171 365523 287324 362384 684179 287321 287329 287328 25194 287325 366151 287310 117264 64803 25310 681706 287313 25329 405239 100911893 287314 259222 405233 259224 64042 25187 287316 300414 29446 117257 500460 309962 690158 84348 29256 363993 295827 300400 295822 295828 363710 103692138 295829 300408 366802 29462 366112 366111 293402 170704 25706 293400 295801 310327 100909438 29471 116700 690334 315452 24664 366100 100910500 292324 100310881 25354 117029 100310886 100310885 25555 363761 363762 363763 309222 293425 300640 366116 366115 366114 293424 295863 293429 294190 293817 295865 293815 293421 24808 29290 295869 24806 24807 294187 294186 293810 287309 300639 100310879 100310878 405242 405249 100310875 405248 293812 366123 100310877 100310876 294394 84583 25570 24604 25569 405252 294198 170926 295858 405258 297795 364275 294197 405218 684376 300643 405219 24415 25195 24613 24416 363546 100912958 25635 25637 81509 311180 405114 363549 405108 293399 405107 293398 29180 311179 293392 293394 103694905 311173 311175 81780 103693363 405106 405105 100910049 300395 24260 103690375 117064 100911586 289023 29191 81779 266997 301086 405287 25320 25321 301088 25323 25324 100911839 680188 295891 295890 362119 360918 405281 66024 114098 114099 679957 353250 300603 405293 314386 287331 100310880 295870 309212 103690156 25340 366377 24659 25342 293375 296675 404984 293377 293373 83633 29385 293374 404986 405131 405132 84007 303296 404978 404983 293379 296679 296678 405136 404977 56820 56821 405137 25616 405138 404976 296687 498475 100910009 288006 689936 405133 296689 405134 24241 338443 404999 404971 405115 404998 690230 405112 287673 56813 502757 292413 140928 140929 404975 293389 292419 293382 404970 404969 292409 404968 298947 25605 404967 680358 405126 405121 502755 404981 293370 405125 405124 405123 24247 405122 89810 363585 405150 687088 103690410 100911398 690821 60448 100909831 54258 406021 24316 405166 365228 289240 405203 24318 405164 405160 289241 687097 100910928 113959 60432 60628 24323 24324 405179 24326 405177 405178 406018 288001 289251 405175 404948 81744 399475 296682 405146 405148 405144 171551 81743 406004 406003 404943 60665 405140 100910719 405141 289261 293808 293809 404963 60451 293805 404962 404961 100363178 405158 81749 404960 296694 81752 405155 100909862 81753 310444 100912515 103693822 25666 100910294 59301 686677 294203 302378 100909884 81503 100909683 295144 58965 294807 100909885 100910224 293336 293338 287613 287614 686660 361076 25645 293334 289076 29141 100911348 293340 100910999 293357 102553138 100912505 293327 404797 100909894 293329 405185 405181 405180 293321 405183 405182 289254 100911796 289255 405171 289250 405174 305236 58966 25689 499149 58959 684683 362505 308776 100911380 362506 293316 293319 406039 500089 404794 100911376 24953 29363 25298 100912217 500347 100912327 100126231 363826 100910599 298006 293761 100365887 293763 293764 293769 25265 300524 300525 501177 287003 114105 367065 24232 367064 295910 684208 293192 116677 100909578 293188 767613 298396 84022 499194 81762 57302 57301 57305 317219 29335 297173 363866 64107 85268 100910467 24797 293333 64680 246759 58949 25652 25653 100909648 314480 245920 690448 301372 497931 29358 64354 497932 367745 293759 100909534 295900 25248 25245 293140 103693685 295907 500101 192649 192648 171101 300560 171519 301610 405362 100912374 405366 171108 103690011 25447 295786 405365 25449 65032 170816 100912540 50577 29581 292661 29597 29595 315571 287000 192646 25040 405373 295772 408199 295771 54248 295766 24938 171371 103690286 295769 295767 295768 25075 405344 405345 405346 405349 314904 287247 25461 287245 295781 378939 171104 405368 405352 295754 24929 103690299 287240 287241 25477 554302 103690280 287237 295751 295750 65275 299553 290493 305841 690472 295744 299242 304985 405391 405390 25026 303835 295712 25432 25024 295713 293773 295732 25007 24769 500157 171158 299570 300599 299757 295747 293781 295743 293789 295741 114492 293785 25229 299576 366668 84475 24903 295729 24772 54293 689869 24473 405966 81638 100911988 299596 59076 59075 366274 299586 287481 299588 366270 287480 690481 25029 405383 25033 405384 295721 379044 405386 287484 287487 288816 288813 404826 100910837 404828 405948 102555599 404825 405955 405963 362454 308408 404820 81657 59264 100911043 364306 408031 404814 408030 404813 81648 404816 404818 24677 405969 100911035 24476 405003 405970 405971 81644 405325 405326 365302 287973 404858 405917 405049 405918 368088 405927 405940 25516 287970 288838 405928 405923 405934 404839 405935 286959 288181 288187 171054 287969 404832 83518 81668 24694 497942 302027 25504 405952 404861 405920 405921 404860 405331 287262 363682 100360071 405333 405050 100909966 405334 686967 405053 282839 405051 405919 405329 405337 50672 405911 288823 100911479 282832 404859 114215 100912097 405912 405915 404855 405914 103690304 114211 404871 404875 290010 404876 405026 405303 405023 290018 58812 286913 365330 288858 59293 365327 365326 365323 289923 365324 100359873 63885 405907 405904 63887 63889 405056 404862 24448 404863 405057 100911670 50678 404877 404878 53949 404879 365334 365337 290009 405307 405312 290003 54223 365336 290001 405033 290005 406163 290006 404885 404887 290008 365340 305509 404891 404894 100363053 405034 499860 404895 404898 64508 404897 100909796 84420 404888 29538 288879 290020 100912605 60590 288869 100910640 287730 364979 288866 290050 304610 405065 405066 29555 405064 100361138 684539 60337 192223 63843 140866 290049 405071 85420 100910120 140595 100909493 288887 688705 499486 288886 293223 287506 288198 100911944 293226 293224 293221 288192 288190 287509 85243 363606 314649 298044 500317 60399 293210 66025 293211 192206 78979 306792 24166 192205 78985 287077 293218 298040 305711 298042 293215 293214 309207 103693022 304289 78982 78983 305795 499913 78980 29254 78981 298038 298039 78984 302954 301334 310999 405990 405993 362648 24816 287088 304193 302045 290541 287080 311647 302958 25537 29316 287082 309653 363639 29413 287081 29412 298046 295378 287086 405991 287084 287083 29310 298049 24180 103693054 24182 298045 100910876 405988 287513 100910162 405982 24179 287516 287090 497978 287517 687110 78964 100909783 287093 405984 287514 405983 499237 405987 405986 405985 81504 25513 313845 85385 116744 498609 29733 29415 302950 89823 24400 25686 81664 25643 365901 282822 363143 25740 60395 286924 171044 29322 89788 81662 24654 266607 81666 309242 25238 29491 680149 24952 29241 24176 25108 246217 140898 310460 361223 78966 84009 310635 361921 64373 303634 363509 307098 296603 304109 687105 114559 117020 293024 100362710 366957 292750 363460 81663 310192 85384 316009 25601 25638 29691 24611 24626 290646 25387 25388 24627 29190 81645 116498 29251 25439 29636 24221 24414 25679 25262 25289 25051 64532 24514 246144 116562 25704 24497 652957 116630 140924 114103 81745 171081 25746 690198 363875 246358 24185 29516 25326 84598 366508 54226 84477 25031 25156 24175 25083 BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME DATABASE ID RELEASE 60%9437994 Beta oxidation of myristoyl-CoA to lauroyl-CoA 170670 171155 25287 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 60%9438000 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 171365 681031 687711 100360682 689116 501688 687679 298075 366468 680737 292884 681062 SIGNALING BY FGFR2%REACTOME DATABASE ID RELEASE 60%9438358 Signaling by FGFR2 289561 316123 116590 500985 103690054 306141 500526 364834 361365 81674 64156 689116 292778 690966 79114 64200 81504 170633 50689 25513 170700 117281 313845 54250 25443 25444 170579 50522 316213 293621 314850 25317 170583 29348 29349 84489 24605 117017 361388 25114 25738 362950 25022 29368 500409 307810 116499 25622 60662 83503 85385 170582 103694903 312510 24525 361655 66017 60464 298075 83805 681260 498109 100361574 24672 363633 24673 498837 140931 100912032 64535 100912534 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME%R-RNO-392170.1 ADP signalling through P2Y purinoceptor 12 64803 24400 25686 81664 25643 286924 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%R-RNO-4608870.1 Asymmetric localization of PCP proteins 291983 289924 289990 58854 307821 29425 64156 83806 287670 29675 50522 29671 690516 29670 24968 25581 24967 307799 29666 315259 117263 117262 364814 290206 161475 85492 83499 303251 29614 29669 689852 303353 681260 287716 29668 292766 29677 29672 365388 81827 498837 287772 100912032 287984 64566 311078 94198 29630 296651 408248 METABOLISM%REACTOME DATABASE ID RELEASE 60%9437825 Metabolism 113965 307092 171516 65984 65030 296623 24306 287424 286896 79111 364380 365410 24913 306490 113976 252898 365652 310155 83842 353498 366697 362360 293829 114554 266604 362261 29692 100363074 114561 500368 315673 65183 102556347 246074 291793 499018 367786 301024 309855 309008 360348 117543 117243 84029 301120 296130 25284 84024 100911615 295631 117278 299193 363026 140607 311341 25045 64310 302640 364298 26759 680971 314438 29580 100188936 690388 307855 290567 300083 293453 296851 302705 25532 114097 171410 83724 25014 89841 500132 89842 65278 288322 25526 25429 365755 81681 25329 25527 116720 300095 366065 367308 25426 307170 25428 304474 25427 287454 25413 366196 308309 310848 317456 25557 171155 170919 314800 79238 50549 84578 84575 365865 359725 296732 287467 287366 293688 308100 171142 117182 266674 25357 117035 116700 114089 24664 171400 25147 171402 363159 681361 302425 678749 314075 25756 81925 295305 81924 246211 25757 293620 366984 85255 363067 298298 360833 29359 292658 361993 308584 308589 296138 288783 24950 29367 50557 293173 84013 84114 304500 503122 361802 360843 296128 301118 291076 314824 305291 304208 25288 25287 291075 315422 29328 305166 301543 64669 309262 362702 25117 25747 301264 619549 296972 29230 170465 362809 307842 29347 25279 64369 360753 25271 100362555 503049 293150 140544 296188 140547 29354 24886 296048 25363 305816 24297 679520 25675 24298 691810 170670 691813 24294 24158 361676 313375 291211 681458 289733 313373 291939 679532 498741 289736 312634 310645 80849 170588 367112 287644 305419 85239 100360507 500892 85421 291182 298579 59103 361659 362782 58962 498962 298369 691905 25682 298423 310667 688517 29411 312086 24192 24197 282584 64304 29527 298947 29526 310773 499358 361631 297694 360521 313339 116699 690610 192242 315173 316039 499174 292697 24539 25728 117533 362015 79127 192357 25649 300027 102549542 25028 78968 500651 24165 103689983 297389 311352 681337 361694 100359680 313786 367808 690163 308518 100910462 498728 291135 296091 361686 29500 94199 497991 691018 100359675 364629 292097 24296 364764 246115 64677 29510 309419 362058 79242 303497 24230 305935 114100 114101 311849 363521 290623 362434 312828 79243 79244 140910 56266 303698 362972 83522 83791 83792 286921 29632 499210 296461 100911154 363675 24693 89812 29743 29740 362039 24384 679565 361433 498331 306582 286936 689872 312947 502749 100911186 362866 83512 29637 365096 29189 289456 54398 64191 311129 25322 683381 84470 24777 29725 29194 81639 289021 29624 502348 100911581 100910957 116482 81727 313997 295674 286904 361401 103689982 406165 287609 114700 317296 619561 313929 85311 290843 295458 192260 24450 305482 83569 680115 114209 361213 291283 679692 305684 171088 94340 361413 316457 81726 60431 315973 192270 114024 298504 687071 306351 289125 192272 50671 691478 116464 81747 306460 309449 79122 116463 309527 191576 191574 296474 497931 63865 497932 25511 300147 60666 60351 404280 313834 25097 50681 60664 305150 290223 311617 500292 54244 81678 58982 25181 291577 292999 29139 286974 84468 50568 114122 500257 304322 25393 81651 296733 291770 306375 302302 297554 314694 316533 25598 252900 300108 25330 25062 24669 681211 25594 25629 363261 79223 24668 79131 80841 25440 499570 316130 24360 25404 29653 313977 316737 64822 363471 79451 362732 54223 305509 64508 84420 360801 287607 83717 316583 65196 288752 313536 305571 362924 291015 84400 100911750 290638 64507 314771 363040 295934 24680 64442 367145 494342 362275 303923 307859 64445 304023 81682 103690116 293667 307404 83626 314360 29204 300129 303631 50555 103690047 298399 303790 362409 308909 24800 360800 302950 114104 684536 303729 363120 288707 299488 64828 310508 94338 313771 316642 365619 83537 310326 300757 117185 246263 293779 361638 29416 311844 171385 59113 64206 66029 116682 311355 29688 680248 365382 688862 306808 499878 294292 290651 171458 316376 59268 50560 94267 367747 282636 83523 501194 363069 296167 300328 103689921 298490 294088 287711 25659 25680 25702 299858 282580 24203 84406 114005 116673 114002 361730 24849 684314 58920 293722 246136 117276 25592 24528 311215 362383 287115 364675 100911625 171517 299907 24190 64468 302489 364682 501157 367166 691394 24401 303218 295443 64152 171408 114860 116569 360630 363618 54283 295352 295351 103690051 290277 25216 691984 497756 360904 24651 287835 25438 684979 100911725 287479 293451 24640 24788 24644 297865 65152 78959 690987 113901 66020 24771 24638 315722 362706 289608 296973 24377 25623 114508 60416 81829 24959 282821 294103 497039 298003 25615 24362 25721 24551 361450 266805 309513 290636 289827 294449 29633 64544 64134 308797 292155 293186 298690 362282 365583 317322 24333 316067 24334 29562 246255 316325 64201 116484 54231 310218 500709 310463 81677 362792 308451 287745 24655 114633 362474 314196 301624 497197 313756 25031 54260 140693 362590 361596 311569 300447 24399 24175 25083 309004 313706 103690164 100169747 100364062 498300 294673 289924 24591 683849 83578 299331 316033 292072 58970 292804 679739 24191 305149 361755 290029 301595 361751 58857 140868 295347 303353 362638 100910990 361378 365388 361467 24157 24159 29142 24189 24390 94198 94197 64640 309147 363024 64537 25290 361819 315085 299052 25052 64035 362249 25581 24426 65029 24917 79239 65197 84431 363494 367562 65192 103690254 171341 84497 289322 25406 362347 408247 690945 297081 25227 362029 25524 25035 362329 83806 24645 287670 311821 81506 25630 81650 289032 24479 24953 312317 102554637 310864 313087 29669 81675 312316 24691 29677 29672 311865 287772 282838 25653 287984 25096 311078 100909857 25095 100362738 24434 289632 64156 50522 29741 85243 25309 681260 29254 100363502 498837 100912032 58819 116719 170551 24624 294972 302422 25513 116686 361884 288240 25104 25738 362757 24710 315644 25056 362558 25703 55939 64047 114106 25571 64076 25552 170580 24782 290959 50719 294255 501103 25027 29504 25139 170698 25658 24904 24778 295417 306866 117267 298280 170943 58978 303565 25059 25351 303205 295245 24400 25686 81664 60449 81667 294962 83579 307641 116549 83817 29253 29539 29503 24267 363516 25559 25081 360426 314459 80848 294324 24653 29322 89788 81662 24654 266607 81666 309242 54225 317576 682507 84018 314641 85238 29699 24679 24896 690825 100912034 83588 252857 680149 307234 24952 245986 29241 25751 305177 298227 298934 288912 361632 25315 24813 24303 24307 80878 293448 24300 297990 293820 362368 294321 299643 303922 310152 500255 29295 25355 81869 7066248 7066247 311655 25634 290551 80899 362344 311254 299699 288617 114096 307852 286963 65200 25331 500820 103691744 308129 7066252 7066251 304429 365962 25375 362810 81805 84608 291660 304024 29215 80900 363129 360975 64203 315439 29261 50572 308190 24860 114613 303905 100910526 316062 300691 304785 29244 24861 29270 360994 499956 24834 292737 117260 300677 24848 292728 299196 303953 500973 24422 24424 83688 25679 25262 64524 685451 25521 171026 64199 25289 25725 25051 114120 64532 29223 246153 296086 114118 171451 293508 291640 114119 114117 59326 171445 25636 25399 79218 29726 25246 24385 291983 64352 311580 24957 296190 116631 116632 301384 100912599 363285 361185 25274 289990 266807 64365 691853 690441 171566 25243 58854 25242 367323 85496 29425 85263 292894 85269 154985 304078 64562 25256 288740 25257 641434 362749 94271 24792 117281 300723 290681 24534 24533 29675 102238592 305889 29671 102550385 29670 24513 24912 24968 79107 24967 293949 310903 171118 114846 245958 29666 295923 64313 117263 682978 117262 245965 26760 364814 245961 290206 29383 25283 103694903 292845 116684 689588 161475 685325 24962 309391 293504 100912521 83499 25297 114123 497811 24244 29646 361215 24312 81522 29614 24314 24311 689852 310856 297508 29611 24239 499330 24368 501454 499328 29634 24250 288259 361992 100145871 100910057 29668 24240 29603 100911564 7066259 7066258 292766 7066257 7066256 353255 363131 7066254 24264 289801 100362634 361272 362720 361274 24672 304944 289036 81827 100910481 24673 298607 289095 500694 362776 499335 361663 290947 498940 305248 498999 85309 290985 681418 619580 24242 497840 292710 499353 29630 81530 296651 680308 408248 113992 100125370 361239 246046 298653 298657 25374 29716 305348 100363268 29301 157074 29309 24172 29711 100912430 100911417 299857 303179 497778 315219 25750 25748 301458 299732 301427 50622 307821 50621 641315 641316 308652 680668 24856 316632 100363253 170898 301005 312670 100365112 289727 100910877 29700 360719 29441 311422 313574 301252 29478 29221 29473 25709 25708 685222 296370 116551 25741 302642 293130 64045 54315 54314 29443 246281 365985 29498 100365773 246245 29487 296259 292915 25732 301011 302669 64001 85492 365972 246253 83472 311446 54349 293991 171128 64392 311536 24902 24185 154516 29723 100911034 498332 29739 171082 171072 299201 171078 286953 171047 299954 65052 300726 295088 287716 299566 314312 311111 361063 116600 64519 288309 309312 309390 64467 288719 316077 294239 613267 103690044 293589 85260 315222 299976 680288 171522 171133 83585 192241 361523 294973 298748 100912604 687861 294964 362653 64300 362657 64305 315648 361510 116593 303563 78975 116599 100911483 294320 29754 79049 24439 282827 60356 364064 574523 24443 291394 50688 683630 192257 316342 24451 58953 315150 293114 366508 501620 81708 287877 29421 291450 81728 499566 299310 312952 100911394 81718 303272 289276 298184 499529 298182 25668 170587 290741 361472 25699 25698 295143 25690 58961 315167 58964 170520 503103 57300 313495 94173 309150 361068 100360621 684425 363061 25642 291819 288088 361071 690050 298881 291824 64473 301123 25488 301622 117544 291084 299735 293700 289014 500350 363085 100270683 299739 685579 678759 361842 53372 679817 299008 294429 362134 266761 300259 56769 299706 24661 65135 84594 26201 292085 287368 117021 24609 304862 117098 24616 24600 690745 25179 25176 58958 312495 245922 310378 113929 290365 65274 691966 689271 287830 685645 25520 84509 295620 25134 293652 116555 84596 26203 362281 26202 300886 25281 293653 293655 683983 25120 295692 306586 89833 291874 54705 81738 288051 499974 300384 751787 252931 113975 100361492 25523 65156 100909612 289219 289218 289217 140946 25497 362196 362335 365592 25611 116721 287379 25612 303676 25618 83535 171178 690848 25603 89813 362588 140925 367201 685999 306574 103691072 362897 63864 191575 81670 25514 361300 81676 297433 25086 25085 311864 365314 100360582 290401 396552 396551 497902 29353 140671 791259 680409 58813 297402 365699 362495 306243 680432 289175 396527 63938 64561 29531 685076 58835 309465 24701 361377 316153 313560 298079 29554 291585 364975 303333 298942 684509 26197 26196 100910127 499688 361385 301221 26194 26199 289950 291952 362428 681913 499689 26192 289197 26193 295229 362404 313520 315023 309070 287063 100910144 298596 64533 360826 64539 310201 140608 287406 29593 114630 54246 680021 54259 25458 29592 287420 300035 25053 312373 54233 312381 54234 54232 64157 360268 171374 171375 246307 362942 307759 300047 308445 171347 171352 366448 317675 300992 300981 300983 64192 300091 296350 296849 81640 362851 81643 83784 311833 83783 363441 361338 294504 81654 308800 297029 80773 294753 79250 362837 79251 362440 25502 103689950 294521 363469 291103 266684 DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME%R-RNO-5654696.1 Downstream signaling of activated FGFR2 79114 81504 170633 25513 170700 313845 54250 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 361388 25114 25738 25022 29368 116499 25622 60662 85385 170582 24525 66017 60464 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 60%9437976 RNA Polymerase III Transcription Initiation From Type 1 Promoter 316810 498109 361102 100361574 690966 685465 294687 690254 306012 246299 299347 362858 685539 117526 310685 311487 300088 100912534 83503 361640 366277 171063 301246 362095 361858 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-RNO-5250941.1 Negative epigenetic regulation of rRNA expression 500351 100360868 680097 679983 295277 100912489 691496 117056 364723 102557184 103693372 680172 291159 102548682 308911 102551184 100360950 302553 TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME%R-RNO-5626978.1 TNFR1-mediated ceramide production 353233 83427 103694380 94338 83537 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME%R-RNO-73856.1 RNA Polymerase II Transcription Termination 116697 687711 288701 314417 680737 171365 311166 313449 689116 361814 29667 291877 307524 308335 690303 309338 295284 100360682 362612 361605 501688 366468 313620 361542 362687 292884 681062 315170 290519 361990 287113 303057 361859 89827 298075 360845 362819 679894 305714 313308 360972 302729 689890 683927 299256 114612 500378 79227 291797 298916 292683 304277 494445 292007 687575 366952 681031 688288 311670 365407 362264 298385 687679 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME DATABASE ID RELEASE 60%9438892 Regulation of gene expression by Hypoxia-inducible Factor 64345 25242 29560 114490 29452 54244 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME DATABASE ID RELEASE 60%9439113 WNT5A-dependent internalization of FZD4 81637 64558 308578 65046 24681 140670 116561 24680 64566 116563 25388 83800 25023 54241 303251 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 60%9438679 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 25150 313494 246331 362398 309280 289392 316639 29751 314641 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 60%9438598 Sema4D in semaphorin signaling 297173 25537 78966 64373 24337 361568 102552659 306400 366957 362993 363875 306790 308875 81762 316009 MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME%R-RNO-430039.1 mRNA decay by 5' to 3' exoribonuclease 103690064 684148 306222 100360750 498934 100909830 361109 291604 315708 364624 362829 361399 297455 290647 500305 500988 361736 TYPE II NA+ PI COTRANSPORTERS%REACTOME%R-RNO-427589.1 Type II Na+ Pi cotransporters 246234 25548 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 60%9438667 Eicosanoid ligand-binding receptors 25637 24816 25652 59264 114098 114099 170926 292661 24929 63889 498475 309212 81752 767613 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%R-RNO-5140745.1 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 81637 64566 308578 65046 116563 83800 306782 54241 64512 140670 116561 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-RNO-110381.1 Resolution of AP sites via the single-nucleotide replacement pathway 29240 84495 303369 79116 INTERLEUKIN-1 SIGNALING%REACTOME%R-RNO-446652.1 Interleukin-1 signaling 291983 303024 303604 289924 25493 289990 308267 58854 363520 307821 29425 64156 113894 291912 296390 83806 24494 24493 287670 29675 313121 50522 29671 314870 29670 500133 24968 309157 679539 24967 25581 305549 29666 301059 25663 117263 362418 305451 117262 305835 364814 309361 361765 290206 309165 29197 315139 311245 161475 85492 84351 114495 83499 100910771 317546 29614 25466 29669 689852 116596 303353 100912618 681260 287716 29668 292766 362356 25166 29677 29672 361677 365388 300177 300084 81827 309452 498837 287772 116725 100912032 287280 287984 311078 309295 94198 29630 296651 81736 408248 362491 REELIN SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 60%9439290 Reelin signalling pathway 25150 84357 266729 24718 310695 25696 ACTIVATED TLR4 SIGNALLING%REACTOME%R-RNO-166054.1 Activated TLR4 signalling 303024 116590 25493 689314 363855 314322 292892 81771 308267 363520 64156 291912 498003 296390 50689 25272 117281 314384 313121 287398 50522 500133 100912585 679539 315305 305549 114509 81647 301059 81649 362418 305451 305835 116663 100363500 309361 361765 289014 81646 103694903 309165 315139 311245 84351 114495 100910771 317546 50658 361565 300980 300447 100912399 116596 116667 303200 315994 100912618 681260 501560 116554 24516 362356 81722 287707 24672 309452 24673 498837 315648 117269 116725 100912032 287280 309295 81736 362491 25742 60587 305751 309957 81525 304859 54226 ADRENOCEPTORS%REACTOME%R-RNO-390696.1 Adrenoceptors 24175 25083 25645 29413 24176 29412 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME DATABASE ID RELEASE 60%9438897 Cross-presentation of particulate exogenous antigens (phagosomes) 499985 100365047 103690020 114553 66021 500904 79129 29184 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%R-RNO-1912420.1 Pre-NOTCH Processing in Golgi 29492 54281 65165 25496 56761 406162 M G1 TRANSITION%REACTOME%R-RNO-68874.1 M G1 Transition 291983 100362333 299112 289924 304573 399489 311562 85242 289990 301323 291105 246327 58854 360908 307821 362304 29425 301430 64156 316273 295596 684111 83806 59102 287670 29675 50522 29671 29670 24968 24967 25581 29666 117263 117262 364814 290206 362817 161475 85492 83499 29614 29669 689852 303353 681260 287716 29668 292766 29677 29672 313138 296178 365388 29728 81827 287524 291927 307126 498837 360621 312538 287772 287961 313479 291137 292071 100912032 29685 291885 287984 288532 296883 311078 94198 29630 296651 408248 CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 60%9439297 Cargo recognition for clathrin-mediated endocytosis 81637 64678 64558 54225 65046 85256 60443 500985 304343 25238 313413 500244 287367 363283 25710 312710 309129 25490 64156 24803 261736 361244 81504 29491 24805 317396 60564 363273 25716 50522 79128 116561 24329 116563 83800 24221 24176 192152 300678 303251 84357 25108 24932 681260 363266 314349 308578 117106 266606 89816 498837 300438 140670 290639 100912032 361120 25387 360915 312689 83730 364033 29528 64566 24825 25388 312694 25151 85491 54241 500564 311030 81645 100909548 116743 498798 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 60%9438634 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 294075 302813 171101 266607 685451 60449 24952 25253 25608 286924 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%R-RNO-1234174.1 Regulation of Hypoxia-inducible Factor (HIF) by oxygen 291983 289924 289990 361831 58854 25242 307821 29425 64156 83806 54244 287670 29675 50522 29671 29670 24968 25581 24967 29666 64345 308457 117263 117262 64525 81807 364814 81920 24874 290206 29560 54702 161475 85492 83499 29614 114490 29669 689852 316101 361258 29452 303353 681260 287716 29668 292766 641452 29677 309434 29672 365388 300084 81827 498837 287772 100912032 287984 311078 94198 29630 296651 408248 HISTIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 60%9437858 Histidine catabolism 89833 309150 29301 299735 81676 24443 685999 CELL CYCLE CHECKPOINTS%REACTOME%R-RNO-69620.1 Cell Cycle Checkpoints 291983 362485 114851 83571 289924 116468 25729 288003 301442 289990 308669 309595 58854 360860 360908 362304 290631 29425 301430 361815 64156 316273 287101 298534 316794 295596 500987 171102 59102 290997 362704 308937 25203 287927 29675 295052 50522 29671 29670 24968 25581 24967 29666 117263 117262 364814 290206 114212 362817 161475 102551184 300711 311575 114494 83499 290805 64046 100362315 363924 29614 680097 306734 301014 85482 689852 295277 100912489 308755 364723 361836 303353 681260 29668 304528 102548682 292766 100360950 500351 313138 296178 365388 29728 81827 287524 679983 291927 498837 307126 297176 360621 296368 312538 360643 498030 287961 116725 313479 29685 100912032 102557184 291885 305420 293155 288532 296883 94198 29630 296651 288414 408248 314856 64557 171576 290875 304798 361389 100910954 100361529 64515 64012 680006 685055 291787 313017 296558 498411 291689 294800 29753 310034 25576 366381 311412 497672 100360936 497856 298795 361831 315969 56011 56010 304490 361662 307821 25577 83806 287670 362827 85492 29669 287716 54237 29677 29672 296099 289468 300126 680537 685474 287772 287984 311078 307511 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 60%9438629 Transcriptional regulation of white adipocyte differentiation 25271 25664 PHASE 2 - PLATEAU PHASE%REACTOME DATABASE ID RELEASE 60%9439143 Phase 2 - plateau phase 29716 300992 114493 171138 140728 29658 84020 25471 140724 24239 246150 140725 140729 116600 84347 306243 140726 682930 140727 50688 312668 58942 25297 SPHINGOLIPID METABOLISM%REACTOME%R-RNO-428157.1 Sphingolipid metabolism 498300 294673 309147 286896 24591 365410 25227 365652 366697 25524 499210 85421 65183 316033 296370 58970 310667 58857 313339 314438 499174 100188936 307404 366984 307855 83626 314360 360833 84431 292658 29204 300129 308589 303631 50555 363494 288783 103690047 298399 303790 362409 65278 361213 301118 366065 305684 315222 304208 60431 192270 301543 500651 308909 306351 24800 360800 282838 289322 114104 684536 303729 64369 363120 288707 299488 100362555 64828 310508 94338 296188 313771 316642 365619 313834 83537 310326 246115 300757 117185 DEUBIQUITINATION%REACTOME DATABASE ID RELEASE 60%9438813 Deubiquitination 291983 297593 289924 289990 58854 29425 498560 29675 295052 29671 115771 29670 24968 24967 29666 117263 117262 364814 290206 29560 161475 114494 83499 29614 689852 303353 29668 292766 365388 81827 94198 29630 296651 408248 314856 64557 304798 100910954 293345 171152 497672 307821 363519 360853 306257 26295 29545 313922 315723 65138 303753 24890 85492 116643 361634 50557 287716 296121 84478 171329 25493 501659 304150 85471 290864 310960 311807 288482 289717 500225 290631 64156 25490 298534 316794 171102 103692172 290997 294790 361107 362704 303539 308896 314453 293494 302488 100910107 50522 29357 297989 100912059 298247 81822 60371 25581 360819 307905 313427 117519 310306 291796 292876 298012 78971 361381 363445 361373 305451 315134 25631 362414 304579 100361658 293570 266601 360471 300222 114558 24176 60331 296084 312688 315523 24919 303201 362636 303351 687696 29240 408217 309512 681260 361015 688466 171565 363084 311856 361190 29591 302415 100190936 499801 309153 363164 290794 103690035 312937 689730 498837 361925 100912032 100362121 65137 287362 291737 25388 316440 311030 498798 64515 361831 291912 83806 287670 361749 313121 500133 315139 311245 140593 100910771 683206 29669 54237 29677 29672 289468 297173 311786 287772 287984 306886 293705 500572 311078 309295 363982 100360606 24205 362491 315911 286761 363599 362788 310677 CRISTAE FORMATION%REACTOME%R-RNO-8949613.1 Cristae formation 192241 140608 114630 26197 26196 100911417 171082 245958 690441 245965 29754 689271 171374 171375 500350 300677 641434 362749 94271 7066252 7066251 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME DATABASE ID RELEASE 60%9438295 Adenylate cyclase activating pathway 25289 24611 305509 64532 302950 54223 64508 84420 29241 FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190377.1 FGFR2b ligand binding and activation 54250 25022 64535 25443 170579 25317 170633 29348 RAF MAP KINASE CASCADE%REACTOME%R-RNO-5673001.1 RAF MAP kinase cascade 291983 171109 24514 246145 289924 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 58854 102552659 170668 29425 65179 64156 24408 25167 64030 24716 24410 24412 117281 24446 498576 29675 50522 29671 29670 29376 24968 25581 24967 29372 690919 25704 112400 29666 24337 24329 117263 117262 116663 364814 290206 24592 103694903 64022 161475 360814 24703 83499 24245 24244 89807 25267 309179 89804 29614 29496 295234 29211 689852 64363 24497 652957 116630 140924 114103 24246 83805 303353 289257 681260 84423 84422 29668 29495 25614 64159 292766 691318 25266 362572 360573 60427 24672 309168 365388 81827 24673 498837 100912032 288924 171081 24242 291245 94198 296072 29630 81511 296651 408248 304893 24586 25746 362045 116590 56011 307821 79114 81504 170633 50689 83806 170700 313845 287670 54250 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 25114 25022 29368 116499 60662 85385 170582 85492 24525 66017 60464 83613 312754 29669 300980 66023 25525 25326 314612 305203 312664 25136 432361 287716 114858 29677 58960 192126 29672 29542 192213 25467 192117 364052 287772 246150 315648 305614 299147 287984 288589 25400 25150 311078 59323 25344 171140 84598 170577 59325 25433 25676 310533 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 60%9438570 Amine compound SLC transporters 171148 295417 363024 282712 83511 79213 79212 310625 116509 65207 365962 29503 85426 117100 664630 293048 50676 113918 24898 298340 54302 294255 171163 29323 29464 54301 25693 CERAMIDE SIGNALLING%REACTOME%R-RNO-193681.1 Ceramide signalling 310738 24596 83537 LAMININ INTERACTIONS%REACTOME DATABASE ID RELEASE 60%9438544 Laminin interactions 114517 85251 25473 81008 192362 302248 307582 309816 316758 360606 305078 25494 140433 25724 298941 117036 CRMPS IN SEMA3A SIGNALING%REACTOME%R-RNO-399956.1 CRMPs in Sema3A signaling 25418 116671 361597 25416 246331 362398 25417 25415 309280 65208 25150 289392 29751 140908 NUCLEOTIDE SALVAGE%REACTOME DATABASE ID RELEASE 60%9437909 Nucleotide salvage 25028 291585 292072 304944 24165 103689983 297389 311352 311864 315219 291824 100909857 290029 499956 25095 24834 295620 117533 362015 79127 192357 362638 289801 BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME DATABASE ID RELEASE 60%9438133 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB 29253 25750 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 60%9438696 Ion channel transport 64156 50522 29708 65187 29709 29707 25674 24947 29517 24703 24245 140675 24244 170667 58963 29695 315272 170699 79246 25451 287715 29705 365946 289606 308016 29694 368044 64190 192258 25456 294141 25450 100912455 24246 681260 683667 299159 64672 685152 367318 63882 89821 679958 89823 60586 24217 361586 171384 25122 24215 498837 24218 24213 24216 293650 24211 100912032 24214 79123 24212 116664 29598 689560 29599 24242 309139 290673 171028 25650 436582 309135 295586 297930 29132 100361584 59299 83615 299971 317599 367086 79430 63866 24767 293874 24768 311287 116477 301111 192675 297566 689779 171497 171498 171496 117596 58950 282822 297797 116469 60395 291969 308022 288026 79425 497948 140933 296981 309407 302422 29693 304315 84494 114246 63847 292168 29600 362645 66026 25688 365391 288371 24941 362247 297932 312896 499287 83810 63848 116455 29639 317420 25749 295041 366545 29232 116831 289407 29233 291555 362802 286920 299714 266730 314401 94170 685232 303856 292597 25391 499474 306811 360932 293735 25390 362053 29757 294329 25400 171140 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 60%9438010 RNA Polymerase III Transcription Initiation From Type 3 Promoter 362858 691501 117526 310685 361102 498109 311487 100361574 300088 83503 100912534 361640 690966 685465 171068 294687 366277 306542 690254 301246 306012 304204 362088 362537 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-RNO-6804116.1 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 362485 314818 114851 83571 295052 25729 308607 362817 114494 MTOR SIGNALLING%REACTOME%R-RNO-165159.1 mTOR signalling 25233 300253 26954 290291 301574 362045 83803 24185 65248 295234 360776 56011 24855 303605 64562 287871 56718 310091 100361543 100912571 301518 501146 298514 116636 83840 295357 117045 78975 292887 100909655 117044 117043 60445 308869 297960 25435 64226 G2 M DNA REPLICATION CHECKPOINT%REACTOME%R-RNO-69478.1 G2 M DNA replication checkpoint 25203 287101 54237 308937 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 60%9437830 Biological oxidations 64352 64076 116631 116632 24306 25243 25242 353498 154985 304078 25256 290681 501103 24912 310903 171118 114846 26760 301595 25283 116684 29646 81522 306866 117267 83724 298280 25429 100145871 100910057 25527 25426 25428 295443 25427 310848 100910481 50549 290947 498940 498999 499353 266674 78959 113992 24664 361239 25147 24172 100912430 25750 308652 100365112 81924 29253 100910877 29539 29441 24267 294103 301252 29473 685222 289827 29443 246245 29487 296259 292915 83472 24902 154516 29739 171072 286953 299566 503122 288309 288719 103690044 293589 171522 361523 301264 64305 361510 362809 25279 25271 282827 574523 291394 683630 24886 192257 58953 24297 501620 24298 24294 313375 312952 313373 25690 500892 503103 57300 362782 58962 298423 25642 690050 64473 24426 246263 291084 293779 361631 65029 293700 361638 679817 266761 690745 312495 685645 293653 171341 252931 100361492 313786 367808 362196 100910462 94199 171178 24296 140925 367201 103691072 25315 24303 24307 24300 297433 362368 25086 290623 29295 290401 25355 297081 396552 81869 396551 56266 25035 288617 286963 396527 25331 24693 309465 316153 298079 25375 100910127 499688 308190 100910526 29189 300691 291952 24861 681913 499689 360994 289197 292728 303953 100910144 24422 24424 312317 310201 311569 286904 54246 114700 25458 313929 25053 312316 360268 171451 308445 171347 171445 171352 300981 300983 83783 79122 297029 80773 60351 103689950 266684 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME DATABASE ID RELEASE 60%9438113 Gastrin-CREB signalling pathway via PKC and MAPK 291983 192649 64636 192648 171109 171101 24514 289924 246145 246144 24628 24629 293847 313874 25453 691774 289990 25597 314596 29434 364686 116562 58854 102552659 29581 170668 29425 65179 29597 25380 24408 29595 81821 25167 64030 25723 24889 24716 24410 24412 117281 54248 24446 24938 292794 498576 171371 29675 360579 29671 29670 29376 24968 24967 29372 690919 497196 25704 314904 112400 29666 24337 24329 378939 117263 117262 116663 170538 364814 290206 24592 103694903 64022 25107 161475 287910 360814 24703 83499 24245 24244 25593 25267 309179 29614 29496 299242 29211 295234 689852 64363 24497 652957 116630 140924 114103 25194 24246 303353 289257 84423 25007 117264 84422 681706 500157 29668 29495 299757 25614 292766 691318 25266 64042 25187 362572 360573 25229 60427 690158 24672 24903 309168 89823 365388 81827 24673 54293 81638 29462 366274 288924 171081 24242 366270 291245 25706 94198 296072 29630 81511 310327 296651 408248 304893 379044 24586 25746 24400 116590 308408 59264 282822 60395 307821 24808 24806 50689 24807 368088 690198 294394 84583 25570 25569 170926 85492 81668 25504 83613 25637 312754 81509 100360071 300980 66023 25525 25326 29180 314612 305203 312664 25136 432361 50672 287716 24260 289023 29191 29322 114858 301086 58960 89788 81662 25320 24654 192126 29542 192213 266607 81666 25467 192117 364052 246150 309242 315648 59293 305614 299147 288589 114098 25400 114099 25150 59323 25344 314386 63887 171140 84598 170577 24448 59325 25433 24659 25676 25342 310533 53949 25238 81771 64156 50522 690230 100912585 25581 292413 114509 24952 100361138 292419 60337 192223 25605 140866 85420 81646 688705 24247 89807 89804 500317 365228 66025 84009 192206 192205 83805 24680 681260 24323 24324 309207 304289 24326 305795 64159 499913 29254 310192 288001 24816 498837 29413 29412 100912032 24180 81749 24179 497978 54226 78964 25666 100909783 362045 59301 302378 56011 361076 289076 79114 81504 170633 25513 83806 170700 102553138 313845 287670 54250 25031 25443 116498 25444 170579 316213 293621 314850 25317 170583 29348 29349 29251 84489 25439 24605 29636 25114 25022 29368 116499 100363500 60662 85385 24221 170582 24414 116744 498609 24525 66017 60464 24953 25298 25679 25262 100126231 29669 25265 501560 116677 767613 84022 499194 29677 57305 317219 29672 64107 287772 58949 117269 25652 287984 100909648 314480 311078 367745 25245 EGFR DOWNREGULATION%REACTOME DATABASE ID RELEASE 60%9438368 EGFR downregulation 84357 50522 500985 498837 306141 362524 361120 64465 100912032 24329 294981 360302 681260 117255 64156 114559 81504 311030 116743 498798 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME DATABASE ID RELEASE 60%9438501 Translocation of ZAP-70 to Immunological synapse 309621 25300 315609 309622 24932 295338 25710 294269 100910488 688090 24981 300678 294270 SHC-MEDIATED CASCADE:FGFR2%REACTOME%R-RNO-5654699.1 SHC-mediated cascade:FGFR2 313845 54250 25443 25444 170579 293621 25317 170583 29348 29349 24605 25022 29368 116499 60662 85385 81504 170633 24525 66017 170700 60464 SIGNALING BY LEPTIN%REACTOME DATABASE ID RELEASE 60%9438793 Signaling by Leptin 291983 171109 24514 246145 289924 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 58854 102552659 170668 29425 65179 24408 25167 64030 24716 24410 24412 117281 24446 498576 29675 29671 29670 29376 24968 24967 29372 690919 25704 112400 29666 24337 24329 117263 117262 116663 364814 290206 24592 103694903 64022 161475 360814 24703 83499 24245 24244 25267 309179 29614 29496 295234 29211 689852 64363 24497 652957 116630 140924 114103 24246 303353 289257 84423 84422 29668 29495 25614 292766 691318 25266 362572 360573 60427 24672 365388 309168 81827 24673 288924 171081 24242 94198 291245 296072 29630 81511 296651 408248 304893 24586 25746 116590 307821 50689 85492 83613 312754 300980 66023 25525 89817 24536 25326 314612 305203 312664 25136 432361 287716 114858 58960 192126 29542 192213 25467 192117 364052 246150 315648 305614 299147 288589 25400 25150 59323 25344 171140 84598 170577 59325 25433 25676 310533 64156 50522 25581 89807 89804 83805 681260 64159 498837 100912032 362045 56011 79114 81504 170633 83806 170700 313845 54250 287670 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 25114 25022 29368 116499 60662 85385 170582 24525 66017 60464 29669 24918 29677 29672 287772 287984 25608 311078 GLUCOSE TRANSPORT%REACTOME%R-RNO-70153.1 Glucose transport 300259 299706 292085 117021 304862 294321 170580 58958 245922 113929 65274 287830 25634 116555 362281 25281 683983 295692 291874 81738 499974 303565 113975 24385 25059 25497 362335 304785 25351 25139 25658 295245 24778 53372 500973 294429 RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME%R-RNO-5362798.1 Release of Hh-Np from the secreting cell 29499 499241 311324 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME%R-RNO-381119.1 Unfolded Protein Response (UPR) 303016 302705 361273 309858 498013 80881 314638 689134 298400 80843 89842 304962 294912 29702 298068 288919 54318 SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME%R-RNO-5358493.1 Synthesis of diphthamide-EEF2 295394 29565 298452 287523 680594 362191 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 60%9438156 Eukaryotic Translation Elongation 29565 171361 300033 363241 293725 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME%R-RNO-68827.1 CDT1 association with the CDC6:ORC:origin complex 291983 289924 289990 58854 307821 362304 29425 301430 64156 295596 83806 287670 29675 50522 29671 29670 24968 25581 24967 29666 117263 117262 364814 290206 161475 85492 83499 29614 29669 689852 303353 681260 287716 29668 292766 29677 29672 313138 296178 365388 81827 291927 498837 360621 287772 291137 313479 100912032 292071 287984 311078 94198 29630 296651 408248 RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME DATABASE ID RELEASE 60%9439168 Recognition of DNA damage by PCNA-containing replication complex 361181 116468 288003 681260 25737 64156 304528 289758 305073 313387 688845 59102 64470 59294 50522 300084 287524 498837 361698 100912032 89809 296883 302502 288414 362412 SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME DATABASE ID RELEASE 60%9439282 Synthesis of active ubiquitin: roles of E1 and E2 enzymes 297593 295686 100362554 298317 361831 103690891 299602 305268 689226 296956 681260 64631 103694506 64156 294331 498560 50522 498837 296368 100909445 289623 100912032 363445 363065 360471 303478 292588 314432 360847 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 60%9438103 Platelet activation, signaling and aggregation 691992 89811 100911551 56782 246328 24514 360950 116727 361714 246144 24854 24628 361196 502858 25259 315707 360942 295703 686539 364206 309186 81804 114111 29434 360457 305679 116562 116635 294643 308291 100359512 81821 54248 24446 24791 81634 25704 499985 170538 445442 308875 24703 24617 85253 24244 24497 25717 652957 116630 140924 114103 295347 64803 81745 25614 25266 24903 89823 24482 24189 81809 171081 24242 291245 81511 24483 25746 25373 100365047 24400 116590 25686 81664 25643 282822 60395 50689 286924 293860 140656 368088 83785 25023 363875 246358 25081 307171 25233 116669 313494 24366 24185 25661 361969 25326 24367 29302 685269 114095 84590 304983 307986 25673 24653 406865 305021 316531 317191 302470 25651 300988 24786 113947 89788 140594 293886 81662 296488 311795 29414 100911881 309609 81666 25358 100912012 25414 297073 363104 500152 309242 293676 360918 171016 307396 81750 363195 25150 64312 500336 54404 58935 309647 287774 60327 84598 299909 498299 63836 116662 245955 312159 50693 366508 116689 304805 299052 81803 59086 252857 299277 24681 24697 25441 100361138 298947 140866 103690020 85420 688705 54249 24944 85243 64373 83805 303634 24680 296603 309207 366957 304289 305795 155918 499913 29254 81663 25522 288001 24816 295378 299276 25387 24825 25388 81749 84491 170924 497978 54226 25666 84477 361076 25524 81504 25513 171337 313845 116498 29251 25439 29636 29184 81649 25622 85385 29186 25155 25156 25679 25262 25265 24175 54245 25083 59326 24936 81515 297173 100911545 497931 497932 367745 24153 116510 PI3K AKT ACTIVATION%REACTOME DATABASE ID RELEASE 60%9438453 PI3K AKT activation 114851 366508 83571 24628 24629 314641 361696 294048 64545 102552659 84482 24954 64030 50686 59109 79240 24506 24505 294235 56718 84027 117281 24446 294515 365367 29376 59265 690919 112400 24337 24329 310131 309361 140607 81646 103694903 246273 64022 296648 64226 310738 25267 29741 309179 29496 85243 83805 24855 361992 81745 302415 691318 25266 58918 60427 24672 24673 365865 292887 314856 309419 116590 79114 81504 170633 50689 25513 89812 170700 54250 25443 25444 170579 314850 25317 170583 29348 29349 84489 361388 25114 25022 29368 116499 25622 100363500 60662 170582 66017 25156 60464 25233 312754 24185 50557 432361 56822 25408 25660 297173 29414 25467 315648 299147 25150 59323 59325 25433 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 60%9438209 Glucagon-type ligand receptors 24953 24400 685451 60449 81667 24166 25024 64199 24769 60432 25051 114120 294962 83579 114118 25040 114119 117064 114117 81779 79218 29446 690825 25321 100912034 680149 29555 24952 245986 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME%R-RNO-73817.1 Purine ribonucleoside monophosphate biosynthesis 315150 288259 295088 117544 684425 362329 81643 301005 361663 287420 140946 289276 GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME%R-RNO-1306955.1 GRB7 events in ERBB2 signaling 102552659 432361 29496 84427 112400 24337 DEFENSINS%REACTOME%R-RNO-1461973.1 Defensins 613221 102554637 103690254 25052 117029 308873 408247 305354 498659 641627 613225 83687 308163 24932 310553 683849 286958 286995 362347 24691 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%R-RNO-1296346.1 Tandem pore domain potassium channels 84429 445371 59324 170899 65272 100909725 688996 499303 64120 116489 29553 116491 DARPP-32 EVENTS%REACTOME DATABASE ID RELEASE 60%9438080 DARPP-32 events 29699 29749 24679 25638 29748 24672 360616 24626 24673 290646 315648 25521 25725 24668 103694903 24627 24675 293508 140908 24674 25636 117281 RNA POLYMERASE I CHAIN ELONGATION%REACTOME%R-RNO-73777.1 RNA Polymerase I Chain Elongation 171150 294693 100360868 680097 295277 100912489 117056 364723 103693372 498109 100361574 84389 690966 291159 102548682 100360950 500351 308415 288651 679983 502227 266713 691496 102557184 25574 363017 117526 297093 690450 680493 361420 83503 100912534 294236 313245 301246 83582 102551184 83581 361580 362728 361784 291703 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 60%9437810 p53-Independent DNA Damage Response 291983 289924 29614 29669 689852 289990 303353 58854 681260 307821 287716 29425 29668 64156 292766 171102 83806 29677 287670 29675 29672 50522 365388 29671 81827 29670 498837 24968 25581 24967 287772 100912032 29666 287984 117263 311078 117262 364814 94198 290206 29630 114212 296651 161475 408248 85492 83499 B CELL ACTIVATION%REACTOME DATABASE ID RELEASE 60%9438276 B Cell Activation 291983 303024 114851 83571 366508 289924 24628 500985 24629 25493 313874 289990 29434 314641 361696 58854 294048 102552659 64545 84482 29425 64156 64030 24954 50686 79240 24506 24505 56718 294235 117281 84027 24446 29675 294515 50522 29671 365367 29670 59265 29376 24968 25581 24967 690919 112400 29666 24337 24329 117263 310131 117262 364814 309361 290206 140607 81646 103694903 309165 246273 308501 171136 64022 161475 316241 296648 84351 64226 83499 681236 361618 84357 171055 305584 29741 25267 100913063 309179 499356 29614 362046 29496 85243 689852 83805 303353 24855 681260 361992 29668 81745 302415 300955 292766 691318 25266 58918 60427 24672 89821 365388 81827 24673 498837 100912032 365865 292887 94198 29630 296651 408248 81525 314856 309419 116590 307821 79114 81504 170633 25513 50689 89812 83806 170700 313845 287670 54250 25443 25444 170579 293621 81678 314850 25317 170583 29348 29349 84489 24605 361388 25114 25738 25022 29368 116499 25622 100363500 361765 60662 85385 25023 170582 85492 24525 25155 66017 25156 60464 25233 312754 25679 25262 24185 29669 50557 432361 287716 362356 56822 29677 25408 25660 29672 29414 25467 287772 315648 287280 299147 287984 25150 311078 309295 59323 81736 59325 25433 GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME%R-RNO-5610785.1 GLI3 is processed to GLI3R by the proteasome 291983 289924 113927 289990 140588 58854 361769 307821 29425 64156 83806 287670 29675 50522 29671 29670 24968 25581 24967 29666 117263 117262 364814 290206 361765 161475 85492 83499 29614 29669 689852 303353 681260 287716 29668 292766 293508 362356 25636 29677 29672 300084 365388 81827 498837 287772 100912032 287280 287984 311078 94198 29630 296651 408248 FRS-MEDIATED FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 60%9439180 FRS-mediated FGFR4 signaling 79114 81504 170633 170700 313845 54250 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 25114 25022 29368 116499 25622 60662 170582 24525 66017 60464 INOSITOL TRANSPORTERS%REACTOME%R-RNO-429593.1 Inositol transporters 252854 171147 SIGNALING BY FGFR%REACTOME%R-RNO-190236.1 Signaling by FGFR 289561 316123 116590 500985 103690054 306141 500526 364834 361365 81674 64156 689116 292778 690966 79114 64200 81504 170633 50689 25513 170700 117281 313845 54250 25443 25444 50522 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 117017 361388 25114 25738 362950 25022 29368 500409 307810 116499 25622 60662 83503 85385 170582 103694903 312510 24525 361655 66017 60464 366061 499308 298075 305539 299236 360903 83805 681260 498109 100361574 24672 363633 24673 498837 140931 100912032 64535 100912534 296072 KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 60%9437917 Ketone body metabolism 24450 65984 367112 314800 79238 25014 690163 295458 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME%R-RNO-354192.1 Integrin alphaIIb beta3 signaling 307171 116669 313494 24366 361714 24185 25661 361969 315707 24367 29302 685269 29434 295347 83805 54245 81745 25614 81504 59326 171337 313845 252857 24697 25414 85385 25155 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%R-RNO-450282.1 MAPK targets Nuclear events mediated by MAP kinases 116590 50658 361565 689314 300980 314322 81771 501560 498003 116554 24516 25272 50689 117281 314384 24672 100912585 24673 315305 117269 114509 315648 81647 81649 116663 100363500 289014 103694903 81646 60587 309957 DNA DAMAGE RECOGNITION IN GG-NER%REACTOME%R-RNO-5696394.1 DNA Damage Recognition in GG-NER 361181 304343 287367 363283 312710 681260 500225 312560 64156 261736 103692172 363273 361107 64470 293494 50522 300084 81822 498837 361925 100912032 100362121 298012 360915 65137 291737 302502 300222 316440 296084 315523 24919 25591 84593 CHOLESTEROL BIOSYNTHESIS%REACTOME%R-RNO-191273.1 Cholesterol biosynthesis 81727 25675 298298 309262 114100 689872 619549 291211 29230 29637 365096 140910 117278 64191 293688 310645 83791 81681 308100 292097 364764 29580 81726 25427 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME DATABASE ID RELEASE 60%9438860 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation 308267 362418 681260 100910771 313121 50522 317546 64156 498837 315139 311245 100912032 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 60%9438707 Tight junction interactions 314259 362279 81918 307799 84006 140581 301112 307237 116479 GABA A (RHO) RECEPTOR ACTIVATION%REACTOME%R-RNO-977442.1 GABA A (rho) receptor activation 29695 29694 192258 3' -UTR-MEDIATED TRANSLATIONAL REGULATION%REACTOME DATABASE ID RELEASE 60%9438155 3' -UTR-mediated translational regulation 64156 299872 100360057 367195 100360619 100911847 81729 681260 291615 498837 100912032 103692785 140655 362952 287417 360572 292964 367865 103690821 100912571 367265 100910180 294282 29236 100360647 100911575 140662 100364265 100360841 103690015 684988 691531 295975 140661 64640 29283 29284 103692831 28298 287436 100360679 26962 64302 302697 103693375 290641 689284 362041 300253 100360117 296709 103694404 296302 317646 29288 81767 29282 81763 100360522 81768 81765 81769 64205 288599 311120 301299 100362830 292148 690468 314652 81775 293427 81770 29752 64638 81776 292762 299027 25348 300069 306079 103694169 293484 288516 65139 297756 100912182 300079 298700 117045 25347 682793 100910370 685963 124440 306926 691947 687780 29258 54318 100911110 100359922 161477 65043 25538 499782 100361079 303831 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 60%9438015 GRB2 events in EGFR signaling 291983 171109 24514 246145 289924 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 58854 102552659 170668 29425 65179 64156 24408 25167 64030 24716 24410 24412 117281 24446 498576 29675 50522 29671 29670 29376 24968 25581 24967 29372 690919 25704 112400 29666 24337 24329 117263 117262 116663 364814 290206 24592 103694903 64022 161475 360814 24703 83499 24245 24244 89807 25267 309179 89804 29614 29496 295234 29211 689852 64363 24497 652957 116630 140924 114103 24246 83805 303353 289257 681260 84423 84422 29668 29495 25614 64159 292766 691318 25266 362572 360573 60427 24672 309168 365388 81827 24673 498837 100912032 288924 171081 24242 291245 94198 296072 29630 81511 296651 408248 304893 24586 25746 362045 116590 56011 307821 79114 81504 170633 50689 83806 170700 313845 287670 54250 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 25114 25022 29368 116499 60662 85385 170582 85492 24525 66017 60464 83613 312754 29669 300980 66023 25525 25326 314612 305203 312664 25136 432361 287716 114858 29677 58960 192126 29672 29542 192213 25467 192117 364052 287772 246150 315648 305614 299147 287984 288589 25400 25150 311078 59323 25344 171140 84598 170577 59325 25433 25676 310533 INTEGRATION OF ENERGY METABOLISM%REACTOME%R-RNO-163685.1 Integration of energy metabolism 29716 24400 25686 81664 54223 60449 81667 116719 305509 294962 83579 306243 64562 64508 312670 84420 117281 29699 24679 24896 690825 100912034 83588 252857 81678 680149 307234 24952 245986 29241 25559 103694903 246253 246255 24778 25297 24953 83688 25679 25262 64524 685451 406165 24239 171078 25176 295347 25521 24680 24175 171026 64199 54234 25289 25725 116600 25051 25520 114120 25083 64532 246153 114118 293508 114119 114117 59326 25636 25399 79218 29322 100362634 89788 300992 81662 24654 24672 289036 266607 24673 81666 302950 50671 24159 315648 309242 78975 25351 83535 25603 50688 24638 TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME%R-RNO-6803205.1 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 25533 58983 24942 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%R-RNO-429914.1 Deadenylation-dependent mRNA decay 100912571 103690064 679140 300045 313243 295050 294975 366017 498934 100909830 361109 291604 316098 308441 297455 287436 300253 100360750 291615 290647 365684 294595 266605 360917 299805 312227 501515 363221 301513 293408 308311 306492 295707 688288 363603 408200 291841 360629 684148 306222 117045 315708 364624 362829 361399 363064 500305 500988 303831 361736 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME DATABASE ID RELEASE 60%9438511 Transport to the Golgi and subsequent modification 252902 246310 306570 24506 24505 287427 65196 313536 29211 363040 289257 25329 64159 301012 289994 310411 171121 300674 361407 361207 100910318 299075 361073 300888 81519 309451 94273 24390 303652 29582 140568 494342 293456 362275 102555167 246117 303923 291990 116700 116666 362599 79120 25407 309144 100363782 81754 304978 25547 309010 84599 65134 360709 361705 294410 432392 308511 140808 65271 361577 100912115 362625 295461 60355 500251 100910557 363858 680465 306264 56042 89868 690252 310710 64154 25423 171049 690961 362162 303100 54350 64351 360611 29631 140673 361502 25478 363136 100360302 315345 100909916 192243 25197 93646 29183 503165 58842 94189 24827 297428 308757 501550 292074 309678 290659 287276 362237 367252 287275 295319 56082 252929 100126191 310843 362504 29167 64462 81655 29564 290798 84428 116659 140734 308961 685144 299850 58817 302470 65165 114023 305614 297522 EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-RNO-3928665.1 EPH-ephrin mediated repulsion of cells 298528 310643 312279 84358 94268 171287 60589 83805 296603 304109 81687 81515 295378 306636 289231 25186 81686 24338 287989 25150 100911293 300802 360546 691658 81751 79208 365872 316539 29210 366492 292788 24884 363875 MINERALOCORTICOID BIOSYNTHESIS%REACTOME%R-RNO-193993.1 Mineralocorticoid biosynthesis 353498 24298 25329 24294 29632 360348 116700 100911154 500892 100910462 MHC CLASS II ANTIGEN PRESENTATION%REACTOME DATABASE ID RELEASE 60%9439012 MHC class II antigen presentation 81637 65046 252902 25697 295461 306332 29448 171293 93646 116563 287276 83800 140694 25751 287275 64310 310843 309621 362504 29167 309622 367038 29211 362044 24984 309159 171574 81655 367304 171529 29564 365542 287624 100909630 290798 360785 84428 314473 29144 171304 116659 361704 290644 287531 294269 294010 140734 294273 308961 294274 100909593 297596 685144 302671 299850 29663 25599 58817 688090 24981 294270 308578 316333 140670 84392 314906 84393 289168 296284 63865 84391 362186 293502 297522 54241 85248 116743 315298 315740 CROSSLINKING OF COLLAGEN FIBRILS%REACTOME DATABASE ID RELEASE 60%9439000 Crosslinking of collagen fibrils 678743 24914 83470 315714 IMMUNE SYSTEM%REACTOME%R-RNO-168256.1 Immune System 100364062 298682 498300 294673 289924 192264 308163 252902 306324 24590 24206 24591 29645 63880 299314 683849 305679 252915 100909700 361208 306332 574531 83578 100909977 306871 315949 100360977 29692 102557319 58826 50692 282817 171293 299331 306891 316033 306600 292072 498840 50645 316035 499271 302495 58970 688730 361537 689064 292073 292804 303542 24191 499985 302890 303413 170538 290029 140607 361635 293118 58857 64310 289185 690130 308869 303414 308875 499157 316014 364867 140868 170667 313658 59313 305234 100360087 295234 316516 499285 116591 50866 63849 361516 316519 295347 303353 679787 100362805 306760 681706 313648 29543 365183 445415 304822 501742 362638 498276 291948 100910990 361378 29153 304966 287709 690158 361677 365388 361171 361467 24157 24159 84397 361370 29142 312647 29511 365865 29143 367915 24189 287721 24390 308632 94198 94197 361697 298066 310612 29714 287813 314618 314615 291000 310416 314856 117029 302934 116590 25402 291755 310553 50993 291339 50689 100912571 287276 25023 287436 50557 362119 117045 303831 499065 688047 299809 292666 299606 246272 29385 309147 308995 301535 84007 363024 64537 292668 314843 29398 25290 29565 116690 361819 29364 291085 291091 116689 499099 499933 292537 29448 315085 315084 83462 299052 295647 117284 25052 64035 362249 287427 690230 299277 79113 25581 292413 103694877 25441 116547 292419 25308 25455 292409 24426 103690020 64189 64185 65029 25046 292306 79209 308350 292594 54243 24917 54249 25319 29292 64046 24944 79239 171361 113940 65197 84431 315272 54258 103694893 304485 116500 363494 690263 304988 171547 100361866 24926 367562 116967 113959 287435 170923 84586 295956 103690289 64159 65192 299159 83841 500361 100361543 114091 103690254 300857 171341 266775 689388 84497 171551 296356 299783 360914 293650 299276 289322 25531 25021 83730 288702 170496 304284 25406 56611 25151 286995 315348 362347 296321 315764 84491 25019 25407 288305 81641 309419 81637 408247 690945 362045 306998 29192 362859 299121 103694857 81503 307483 156767 66021 297081 25227 362029 690492 289318 432363 81683 25524 25035 25328 362329 81687 25423 25528 117152 89812 83806 24645 171337 83527 287670 498209 259275 290257 361422 311821 81506 24257 24256 25630 89824 83799 289231 81650 29184 498128 81649 289032 498234 192177 29738 309684 24251 362966 296654 296655 29186 24479 83781 252929 364705 312317 102554637 361598 310864 690906 60350 313087 29669 81679 363522 362432 25518 81675 289211 312316 25619 498022 24248 286958 114105 24232 363463 29757 294329 408224 289820 24691 288174 408229 290923 25505 81762 29677 100364984 689955 29672 297173 100125364 290409 311865 316333 298792 114023 287772 58949 282838 79129 287984 303666 25096 311078 79130 100909857 63865 25095 100362738 24434 29662 100134871 81736 362893 313837 289632 25097 24223 102557244 298317 305268 310131 296648 688288 304859 25050 29432 64044 24674 117553 54244 502902 360640 64171 288375 288378 363856 360647 81678 311658 100361818 100360982 501797 100910732 361400 83477 314432 54223 301442 298508 305509 64156 690966 64508 84420 50522 81822 361509 83503 85420 89807 29741 89804 85243 287437 83805 24680 681260 498109 100361574 78963 58918 300084 498837 295378 116725 100912032 29431 29433 100912534 29748 56011 295461 100910646 300968 362900 308968 24224 100359528 302422 288921 313722 362376 79114 80897 81504 170633 25513 140941 366854 170700 310363 303336 313845 363083 100360914 54250 300849 25443 306825 25444 170579 317241 316213 171043 293621 500587 314850 311373 25317 690769 81815 170583 93646 29348 29349 85273 84489 308283 24605 678726 361388 301674 25114 364681 25738 306129 25022 50558 311881 29368 116499 313782 25622 313101 292757 60662 85385 498089 170582 287275 303215 362367 287552 140593 498941 300724 24525 66017 117524 310843 60464 100125363 309444 362002 291597 362081 361907 362277 502852 363188 498959 362511 64517 301015 302987 312504 305424 301000 313806 494223 308999 60383 685144 360818 363790 304522 58817 361354 309453 316575 308901 295279 192351 302950 297522 259242 24508 690894 304349 305842 361714 25235 24854 685844 689757 315707 317676 24684 310178 295703 686326 684984 54266 25697 685048 24683 24481 308417 309620 361696 24934 294048 25069 64545 84482 25464 305896 65261 306204 359726 171369 25008 24954 50686 296872 304987 79240 293774 24506 100911527 24505 307199 313785 294235 689790 299567 84027 501828 498888 308873 500331 641627 292671 294515 301133 83687 301132 365367 301626 59265 50585 500318 100912356 289395 304382 303861 300756 25066 309304 289057 24283 493810 287818 295704 29333 29337 311559 308501 288568 171136 363275 316241 64357 288774 103690070 498666 500338 100912314 290749 681236 25361 298205 361618 499342 171055 313644 305584 100913063 361628 499356 680910 100910725 362046 114709 360655 24391 298211 361873 361673 298210 498284 498287 298696 24236 24235 24560 25713 24233 306956 306957 24237 295180 24599 24598 498079 298693 312705 155012 365581 685157 498206 365466 312711 288264 89821 683758 498241 24258 24231 502965 502966 303298 89814 502962 684480 685161 299354 29687 113936 353218 300649 366518 29684 25572 474146 25126 25621 29169 103694852 24667 113937 25341 297604 297566 689779 117596 297797 291969 296981 24941 297932 116455 366545 289407 362802 500904 94170 685232 24884 684969 360620 360426 362504 29167 58823 367038 295338 24984 81655 171574 89817 367304 365542 29564 100909630 290798 360785 29144 84428 361704 116659 290644 287531 140734 294273 308961 294274 313024 100909593 297596 299850 302671 29663 407756 25599 287876 297481 360777 302965 100910669 65172 315610 501779 301009 501502 501116 681341 313264 500592 29414 679934 500590 79249 497963 361390 298573 287034 364049 501738 681182 499658 303073 298566 63835 81750 192262 103694381 103689997 406161 100910801 309081 689817 361251 103689965 499415 362271 54227 362445 117542 100361457 362447 103689974 114553 296545 103690314 689853 362443 296562 117538 288669 114851 54225 83571 65046 25238 682507 314641 25710 294790 29699 24679 297989 252857 60371 24681 24697 29241 78971 361373 116563 83800 140694 25751 81732 312688 300678 309621 84357 25300 363577 315609 309622 368044 29513 296603 294269 499537 60352 302415 300955 100910488 688090 155918 24981 317371 312937 294270 310727 308578 29691 140670 297518 287362 116664 29665 117514 436582 54241 300732 290408 116743 58923 315435 299971 498769 100911854 64668 500910 690076 246238 361710 299827 360548 298288 445269 652929 100909750 25110 293618 314336 301227 301229 299928 246244 64459 499069 305081 84349 296290 500491 24620 311860 25192 683163 292545 309014 501869 680844 360557 313421 311430 363984 294257 29251 84355 54303 302424 25679 25262 362044 309159 171529 287624 64465 314473 171304 25521 103694380 25289 25725 64532 293508 56822 59326 25636 25408 25660 311786 84392 311144 314906 84393 289168 296284 310695 84391 362186 293502 298702 85248 315298 315740 291983 305354 171109 305353 24514 246145 246144 24628 24629 293847 317468 29260 313874 25453 684440 680127 289990 25597 364594 314596 292892 685174 29434 310461 364686 116562 58854 102552659 170668 29425 361689 65179 246116 24408 314764 25167 312562 64030 64023 24716 24410 24412 64202 56718 117281 24446 361289 498576 29675 366588 29671 29670 362862 29376 360697 24968 117063 24967 300772 29372 690919 252971 25704 116465 112400 29666 24337 24329 362858 117263 117262 310685 116663 311487 364814 290206 300088 25712 24592 103694903 361640 246273 64022 366277 161475 301246 360814 24703 64226 83499 24245 24244 497811 338457 25267 309179 29614 29496 29211 689852 64363 24497 652957 116630 140924 114103 24246 24855 289257 84423 361992 84422 29668 81745 29495 25614 292766 691318 25266 363131 362572 360573 60427 24672 309168 81827 24673 292887 288924 171081 24242 291245 296072 29630 81511 296651 408248 304893 24586 25746 25374 29205 25373 100365047 301574 308666 360854 25739 288779 363127 84387 29214 301034 367455 293753 293154 307039 299732 94167 307821 84386 303180 317335 64350 24856 310710 24812 64529 246250 301005 24811 64527 361619 308394 25217 684322 103689996 613221 304688 498659 613225 301252 29221 296076 140656 296370 25741 293130 690198 691533 100361909 307833 304543 85274 295706 363247 140665 301261 100911825 474169 497195 84379 103693683 85492 116643 363875 246358 315306 304692 25233 83613 312754 24185 300980 66023 25525 25326 314612 305203 312664 25136 65052 432361 294010 287716 315222 25103 302526 292485 114858 58960 192126 29542 192213 25467 192117 364052 246150 315648 305614 299147 288589 25400 25150 59323 25344 116484 171140 84598 170577 59325 25433 25676 310533 117539 303024 296541 366508 303604 116470 500985 25493 689314 362896 311783 245983 363855 314322 81771 689932 308267 500616 363520 25610 288905 113894 100360218 171060 498003 155140 296390 25272 24498 171040 691516 81803 24494 24493 29201 81802 287398 314870 25734 100912585 309157 315305 89829 305549 114509 301365 81647 301059 100361294 297520 305451 287942 685840 309361 289014 81646 309165 29197 290655 84351 24600 81722 287707 25742 305751 81525 54226 361831 25325 84477 252963 308716 291912 681112 29469 314384 24500 361749 313121 310132 304091 500133 688622 679539 25124 81680 444986 171334 171333 25125 304061 25663 25670 362418 305835 100363500 361765 362629 362628 84492 315139 311245 25205 362417 25155 114495 25156 116558 501043 171379 100910771 317546 683206 25466 50658 24932 361565 300447 365395 54259 100912399 116596 116667 303200 25556 681145 289747 315994 24918 100912618 361102 312679 501560 171106 54245 291159 685465 116554 367264 24516 116553 690254 362356 306012 25166 54237 100911248 287287 63881 170819 294797 81515 300177 309452 680609 301289 501996 682457 691496 117269 287280 50646 116996 313173 500836 25707 362076 362077 309295 29175 25084 298518 306247 307403 362491 64546 60587 309957 362788 84405 60584 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-RNO-2142770.1 Synthesis of 15-eicosatetraenoic acid derivatives 29527 29328 266604 81639 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 60%9438555 Peptide hormone biosynthesis 24504 29200 64549 25329 25204 116700 25447 24664 25653 SIGNALING BY ACTIVIN%REACTOME DATABASE ID RELEASE 60%9438300 Signaling by Activin 29200 25631 245921 29357 24373 29381 300054 114031 293674 29263 SUMOYLATION%REACTOME DATABASE ID RELEASE 60%9439065 SUMOylation 301442 308669 309595 25737 314949 300772 297893 63996 29486 102551184 313304 53372 25591 315958 294429 300259 299706 303874 680097 114521 292085 117021 304862 295277 100912489 308755 364723 58958 245922 113929 65274 287830 312560 84576 102548682 25573 103689978 116555 308384 362281 78973 65026 25281 100360950 300193 308508 683983 295692 679900 500351 291874 81738 499974 679983 287524 113975 102557184 25497 362335 499417 84593 497672 84577 309995 501145 313961 297561 25094 299957 64520 500545 316164 83422 114592 362965 293733 367152 315713 287662 293967 362827 361645 83614 64550 499179 64041 362280 60373 363287 296099 313038 362581 309626 304850 303730 303731 501403 310258 307151 312690 CELLULAR RESPONSES TO STRESS%REACTOME%R-RNO-2262752.1 Cellular responses to stress 291983 289924 252902 289990 25242 58854 29425 287871 56718 299331 29675 295052 29671 29670 24968 24967 29666 64345 308457 117263 117262 64525 81807 364814 24874 290206 29560 54702 362817 161475 300711 114494 64226 83499 24245 29614 689852 316101 361258 24246 29452 303353 29668 292766 365388 81827 296368 360643 498030 305420 293155 292887 94198 29630 296651 408248 314856 304798 114483 100910954 64012 116590 685055 310511 94167 307821 304063 94201 25261 50689 24356 292721 54238 25164 54244 301252 500904 85492 116643 362504 29167 81655 29564 290798 84428 116659 140734 308961 287716 299850 24786 313038 365057 315136 362809 362581 309626 25400 304850 293104 312299 303730 303731 171140 116484 501403 498183 310258 313048 114553 303259 363630 307151 312690 362485 114851 83571 25729 689314 363855 314322 81771 64156 25272 59102 287398 50522 100912585 83712 25581 114509 24426 81920 289014 102551184 53372 294429 64046 300259 299706 100360868 171361 680097 292085 85482 117021 304862 295277 100912489 117056 364723 58958 245922 113929 25309 65274 103693372 681260 287830 102548682 116555 641452 362281 25281 100360950 100363502 683983 295692 500351 291874 81738 499974 300084 679983 287524 113975 498837 367808 102557184 100912032 25497 362335 296883 290875 361389 58819 117254 25506 296558 29753 291689 366381 311412 100360936 361831 66021 304490 116686 83806 287670 113906 81649 114495 84581 297998 293103 24787 302935 297994 94165 65028 363849 286899 50658 114490 690237 294408 29669 85431 100911837 84026 293524 361403 303536 303200 362078 192277 103689963 500054 79462 315994 24248 690038 25420 307861 100910067 501560 297758 84485 307798 291159 25154 116554 25352 361167 24516 314642 298376 361384 300721 361798 29677 290232 689955 309434 29672 691496 287772 117269 79129 287984 24963 103690404 260321 311078 362293 50551 361810 79245 81800 294744 304569 306007 171562 64371 24253 366734 288444 THE ACTIVATION OF ARYLSULFATASES%REACTOME%R-RNO-1663150.1 The activation of arylsulfatases 307404 24800 360800 303631 365619 315222 310326 362409 25227 PLASMA LIPOPROTEIN CLEARANCE%REACTOME DATABASE ID RELEASE 60%9438306 Plasma lipoprotein clearance 81637 54225 65046 314459 64474 80848 25728 298296 25292 100910181 24538 308578 680551 266732 306825 25055 499264 58852 81782 266770 300438 58851 140670 294930 116563 83800 25073 25696 54241 500564 25081 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 60%9438464 AKT phosphorylates targets in the cytosol 314856 24855 292887 114851 83571 309361 24185 50686 58918 84027 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 60%9438255 MAP kinase activation in TLR cascade 303024 116590 689314 363855 314322 81771 308267 363520 64156 291912 498003 296390 50689 25272 117281 314384 313121 287398 50522 500133 100912585 679539 315305 114509 81647 81649 305451 362418 116663 100363500 309361 361765 289014 81646 103694903 315139 311245 84351 114495 100910771 317546 50658 361565 300980 116596 303200 315994 100912618 681260 501560 116554 24516 362356 24672 24673 498837 315648 116725 117269 100912032 287280 309295 81736 362491 60587 309957 RNA POLYMERASE II TRANSCRIPTION%REACTOME%R-RNO-73857.1 RNA Polymerase II Transcription 289924 79240 292804 501688 366468 364298 308869 292884 681062 295234 298696 303353 25533 58983 25329 24942 360917 299805 312227 363221 301513 308311 306492 295707 363603 365388 291841 94198 116700 314856 303132 304798 266787 301119 311796 100910954 25562 305851 294258 287608 306261 306347 81785 305455 303281 291705 307641 116549 24890 314993 314818 308607 25747 25271 307511 286917 306665 362485 362675 114851 690728 83571 25729 83574 300807 306862 252917 58839 303241 361630 100363472 360896 619579 311807 499670 292064 361128 290995 58850 100910137 58853 50659 60349 361391 686781 679028 313777 361374 290744 25664 305025 305120 291736 25203 305837 114491 171355 691278 309200 83722 54278 25682 362342 297767 290669 25581 299694 365744 297822 252924 362125 365895 362834 140923 259241 299210 316216 685072 29619 306817 103689975 298688 102549712 58936 684085 298681 691379 192350 299810 290805 245980 116671 64046 304514 100362315 363924 24831 117535 116698 306734 301014 293701 85482 361988 64314 300782 117274 361724 24706 24705 308755 301285 361836 309288 65035 311613 311414 289372 685619 83826 289382 294276 296102 100911519 103690163 25149 100359464 290322 362272 303101 100361543 314862 100909544 314465 307829 81808 24873 25735 362813 360589 25112 81812 497991 361057 311591 308582 246334 309918 140908 84385 293625 100365683 24887 362045 306998 89812 83806 84577 287670 114592 315713 81650 81649 362280 363287 315170 290519 361990 303057 114490 29669 89827 360845 362819 679894 362078 305714 29417 313308 360972 302729 114612 500378 79227 291797 25154 361798 29677 29672 58852 685474 25496 58851 314756 56761 287772 406162 363227 310614 679713 287984 308837 311078 29492 60351 291983 26954 293184 289990 58854 300837 29425 366169 64562 287871 56718 117281 282844 301518 29675 298514 295052 29671 140926 115771 29670 282845 24968 24967 29666 117263 117526 310131 117262 64525 81807 103694903 29517 171068 114212 362817 161475 60445 296648 304204 300711 311575 64226 362088 114494 83499 25405 287113 361859 29614 689852 298075 24855 689890 29668 81745 292683 494445 292766 691318 687575 366952 310091 681031 688288 24672 81827 311670 24673 365407 362264 298385 29630 687679 296651 408248 297960 64557 116550 103695118 288533 81673 100361529 291773 64012 682902 294018 685055 291787 83828 498411 293345 310784 294800 171152 310034 100360100 497672 310511 497856 315969 306516 303918 83830 307821 24377 307485 170844 54244 85492 305909 83803 24185 65248 311546 360776 287716 295357 261730 315648 78975 100909655 117044 363064 116484 498183 117043 313048 361531 304832 171150 364382 289561 294693 116468 288003 689314 103690054 301442 364834 362594 361365 25737 84389 64156 292778 690966 59102 304758 308415 288651 59086 300947 29357 50522 365894 690516 83712 306571 680111 502227 114208 499929 297893 300813 117017 362110 689820 363292 363445 84396 25631 81920 360801 83503 315291 360471 100360427 58919 361178 116651 25591 316742 291703 83805 362479 681260 498109 100361574 500715 304528 84576 25573 500695 641452 24790 295062 363633 287524 498837 266713 100912032 296883 363014 100912534 294236 288414 498453 361580 116697 294518 687711 502894 288701 316123 58819 314417 117254 140942 313017 29753 25576 680737 298795 361831 56011 56010 171365 311166 81674 313449 25577 689116 361814 502988 116686 29667 291877 307524 308335 690303 309338 295284 100360682 362612 361605 313620 361542 362687 24525 114495 691501 683927 299256 291534 313131 308472 298916 304277 292007 54237 362537 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME DATABASE ID RELEASE 60%9438365 APC-Cdc20 mediated degradation of Nek2A 171576 290875 361389 64515 296558 291689 366381 311412 114482 100360936 361831 304490 361662 681260 690209 64156 50522 297176 498837 296368 360643 498030 100912032 305420 293155 BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME%R-RNO-77305.1 Beta oxidation of palmitoyl-CoA to myristoyl-CoA 170670 171155 25363 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%R-RNO-174411.1 Polymerase switching on the C-strand of the telomere 59294 25737 116468 304528 288003 289758 288414 85242 361698 301323 246327 89809 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%R-RNO-912526.1 Interleukin receptor SHC signaling 291983 171109 24514 246145 289924 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 58854 102552659 170668 29425 65179 24408 25167 64030 24716 24410 24412 117281 24446 498576 29675 29671 29670 29376 24968 24967 29372 690919 25704 112400 29666 24337 24329 117263 117262 116663 364814 290206 24592 103694903 64022 161475 360814 24703 83499 24245 24244 25267 309179 29614 29496 295234 29211 689852 64363 24497 652957 116630 140924 114103 24246 303353 289257 84423 84422 29668 29495 25614 292766 691318 25266 362572 360573 60427 24672 365388 309168 81827 24673 288924 171081 24242 94198 291245 296072 29630 81511 296651 408248 304893 24586 25746 116590 307821 50689 85492 83613 312754 300980 66023 25525 25326 314612 305203 312664 25136 432361 287716 114858 58960 192126 29542 192213 25467 192117 364052 246150 315648 305614 299147 288589 25400 25150 59323 25344 171140 84598 170577 59325 25433 25676 310533 366508 64156 116689 50522 25581 89807 89804 85243 83805 681260 64159 498837 100912032 362045 56011 84477 79114 81504 170633 25513 83806 170700 313845 54250 287670 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 25114 25022 29368 116499 60662 85385 170582 24525 66017 60464 29669 54259 29677 29672 287772 287984 311078 FRUCTOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 60%9439169 Fructose biosynthesis 24788 24192 REGULATION OF KIT SIGNALING%REACTOME%R-RNO-1433559.1 Regulation of KIT signaling 313845 60427 24680 25150 81515 500985 116689 64030 81504 24884 83805 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%R-RNO-450531.1 Regulation of mRNA stability by proteins that bind AU-rich elements 291983 289924 289990 56011 58854 307821 29425 64156 83806 100912571 287670 29675 50522 29671 29344 103690064 29670 679140 24968 300045 313243 24967 25581 295050 294975 300944 366017 29666 100909830 361109 291604 117263 316098 117262 308441 170538 364814 290206 289014 161475 85492 83499 24185 29614 29669 689852 287437 303353 25379 24680 681260 85252 287716 291615 363854 29668 292766 29677 689955 29672 365388 81827 498837 287772 171137 24471 100912032 287984 311078 94198 29630 296651 408248 79256 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME%R-RNO-446353.1 Cell-extracellular matrix interactions 363509 362332 362973 170922 499443 361517 680419 293860 81634 362650 289992 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 60%9438907 PI3K events in ERBB4 signaling 59323 64022 690919 59325 25513 25433 112400 PLASMA LIPOPROTEIN ASSEMBLY%REACTOME DATABASE ID RELEASE 60%9438340 Plasma lipoprotein assembly 25292 100910181 54225 680551 310900 313210 303796 25506 100911545 292697 25728 287276 83470 24153 293508 25649 25636 25081 ACYL CHAIN REMODELLING OF PI%REACTOME%R-RNO-1482922.1 Acyl chain remodelling of PI 362039 690388 308309 691810 29359 103689982 691813 691905 24913 295631 296091 29526 24653 297694 29692 29354 298579 MELANIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 60%9439196 Melanin biosynthesis 298182 100365773 308800 310152 MRNA 3'-END PROCESSING%REACTOME DATABASE ID RELEASE 60%9437892 mRNA 3'-end processing 116697 288701 314417 311166 313449 689116 361814 29667 291877 307524 308335 690303 309338 295284 362612 361605 313620 361542 362687 315170 290519 287113 361990 303057 361859 89827 298075 360845 362819 679894 305714 313308 360972 302729 689890 683927 299256 114612 500378 79227 298916 291797 292683 304277 494445 292007 687575 366952 688288 311670 365407 362264 298385 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME%R-RNO-446219.1 Synthesis of substrates in N-glycan biosythesis 295051 498272 298541 25547 83505 363103 298071 24591 302972 316033 311847 502017 312826 29758 296394 114711 311530 302915 296370 29640 304860 25197 300741 297393 303692 81759 300089 291095 25280 293587 294400 307848 296624 300036 360518 299346 304954 407765 407764 498486 287920 301155 297417 116696 310935 501167 100911225 364901 363109 313139 362924 29204 103690047 363040 311204 305291 81726 64442 316642 64445 304023 117185 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%R-RNO-983231.1 Factors involved in megakaryocyte development and platelet production 24508 497976 690894 24514 94164 367039 300266 171120 499337 103694857 54254 85471 293267 313438 292892 361512 24481 25172 499951 293692 64476 502359 294520 500491 25159 691504 366960 312562 314930 306941 114124 360540 259237 246760 100911527 361619 26956 366998 54244 64516 29699 24679 100912356 689064 493810 363875 100912314 290749 298205 100360868 362044 309159 298211 89817 171529 287624 117056 298210 64465 314473 171304 500709 25521 103693372 25725 291159 293508 25636 64188 192249 103689972 100911485 298584 502965 502966 691496 502962 84392 314906 84393 289168 296284 309081 84391 362186 293502 100134871 85248 103690314 315298 315740 FGFR2 ALTERNATIVE SPLICING%REACTOME DATABASE ID RELEASE 60%9439251 FGFR2 alternative splicing 289561 363633 316123 103690054 298075 364834 140931 117017 361365 362950 500409 307810 81674 498109 100361574 83503 689116 292778 100912534 690966 64200 312510 361655 GPCR LIGAND BINDING%REACTOME%R-RNO-500792.1 GPCR ligand binding 192649 64636 192648 171101 25360 171519 308163 25369 100124593 171108 691774 25447 25449 65032 246219 29238 50577 25111 29581 292661 29597 25380 29595 117027 25726 192646 25723 25040 24889 25370 408199 360750 24938 292794 171371 360579 54305 25075 29234 301066 497196 29237 25461 690572 378939 171104 24929 25107 25477 287910 554302 25593 290493 690472 24419 299242 25026 25432 25024 25194 25007 117264 24769 64803 500157 681706 171158 25329 299757 259222 259224 64042 25187 114492 29446 25229 366668 690158 84475 84348 24903 29256 24772 689869 24473 81638 29462 366274 170704 366270 25706 690481 25029 310327 25033 29471 116700 690334 24664 379044 100310881 25354 100310886 100310885 24400 25555 362454 60449 308408 81667 81657 59264 81648 294962 83579 24808 24677 29290 24806 24476 24807 81644 100310879 100310878 100310875 100310877 100310876 690198 25516 294394 25570 24604 25569 171044 170926 297795 171054 83518 81668 24694 497942 24415 246358 25195 25504 24613 24416 25635 25637 81509 363682 100360071 29180 282839 103694905 81780 50672 282832 24260 114215 117064 289023 29191 81779 114211 266997 301086 679975 685243 170896 25321 25323 266607 25324 63850 58812 680188 288995 170634 117549 362119 367315 29151 360918 29407 66024 688605 60669 114098 246075 114099 171056 679957 89808 353250 316019 292310 94204 314386 63887 497078 63889 100310880 29625 309212 24448 103690156 252939 25340 297025 408243 24659 302619 25342 53949 83633 29385 84007 56820 25616 100363053 498475 689936 29538 24241 338443 60590 690825 100912034 287730 690230 287673 680149 56813 502757 292413 29555 24952 245986 292419 60337 192223 292409 25605 63843 24176 24247 89810 25108 60448 54258 314649 24316 500317 60399 365228 66025 192206 78979 306792 24318 24166 192205 78985 60432 113959 60628 24323 24324 24326 78982 78983 78980 78981 288001 78984 25601 399475 24816 171551 29316 29413 29412 60665 29310 24180 24182 100363178 29190 24179 81645 81752 81753 54226 310444 78964 100909783 59301 445269 302378 81503 295144 58965 294807 25524 25645 29141 102553138 116498 100911796 29251 25439 29636 305236 58966 25689 499149 58959 24221 362505 295401 24414 116744 362506 498609 29733 29415 500089 24953 29363 25298 500347 685451 298006 25265 24175 501177 64199 114105 287003 24232 25051 114120 25083 116677 114118 114119 114117 767613 84022 499194 79218 57302 57305 317219 29335 363866 64107 85268 24797 64680 246759 58949 25652 25653 100909648 314480 245920 690448 29358 64354 25248 25245 500101 HSF1 ACTIVATION%REACTOME DATABASE ID RELEASE 60%9439090 HSF1 activation 84581 171361 301252 79245 29753 116643 367808 103689963 362809 299331 CD209 (DC-SIGN) SIGNALING%REACTOME DATABASE ID RELEASE 60%9439157 CD209 (DC-SIGN) signaling 314384 288375 288378 81515 363856 360647 293621 100360982 501797 24605 100910732 29431 25150 29433 309165 29432 293508 81736 24525 24703 25636 54244 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 60%9438180 Post-translational protein modification 289924 252902 24591 63880 299314 50692 316033 29237 100911615 89842 303353 25329 367308 304966 365388 29142 24390 94198 116700 314856 304798 100910954 363519 360853 306257 26295 29545 313922 315723 65138 303753 24890 287276 50557 305291 361676 29565 287427 25581 24197 171361 308755 25728 64159 288001 25649 300027 25531 288702 100359675 84491 25407 362859 25227 25423 117152 83806 287670 81506 252929 29669 24232 81726 29677 689955 29672 297173 114023 287772 287984 311078 100365043 295274 297593 295686 100910200 313216 680403 100362554 293184 24829 100912338 298317 308282 103690891 299602 305268 689226 296956 361247 300837 64631 103694506 100909787 297337 366169 306969 294331 64647 680312 498560 100909597 266712 296360 316400 295052 115771 353304 116718 289623 293561 295543 303277 300046 103691942 64345 64525 81807 24874 29560 114494 361258 29452 24903 64557 497672 117553 114122 25661 361969 24367 684797 680424 100909445 83477 100364835 307029 295568 306945 363065 363064 29534 100359692 303478 292588 314432 362412 361531 312703 360847 291157 361181 304832 304343 301442 287367 363283 312710 500225 25737 64156 261736 103692172 363273 361107 293494 287927 50522 29357 81822 297893 361509 298012 363445 25631 81920 54281 360471 300222 296084 315523 24919 25591 316583 65196 288752 313536 305571 362924 100911750 290638 363040 681260 312560 84576 29591 641452 103690035 64470 300084 287524 310071 498837 361925 116725 100912032 100362121 360915 65137 291737 64442 494342 362275 302502 303923 316440 64445 304023 499417 84593 293667 295461 100359528 288921 313722 366854 310363 303336 363083 100360914 300849 171043 500587 170583 93646 85273 308283 678726 301674 306129 311881 313782 313101 292757 287275 303215 140593 498941 300724 117524 310843 307404 100125363 309444 362081 361907 29204 498959 303631 362511 301015 103690047 312504 362409 305424 494223 308999 685144 360818 363790 304522 58817 361354 309453 192351 24800 360800 361029 297522 316642 365619 310326 117185 363103 25473 59107 304135 116635 83727 25353 24506 24505 117036 25312 445442 298941 313139 366061 311204 25533 58983 24233 24942 25296 301012 289994 310411 171121 300674 361407 361207 100910318 299075 361073 300888 81519 309451 94273 303652 29582 140568 293456 102555167 246117 291990 116666 362599 79120 309144 100363782 81754 304978 25547 309010 84599 65134 360709 361705 294410 432392 308511 140808 65271 361577 100912115 362625 60355 500251 100910557 363858 680465 306264 56042 89868 690252 64154 171049 690961 362162 303100 54350 64351 360611 29631 140673 361502 25478 363136 100360302 315345 100909916 192243 25197 29183 503165 58842 94189 24827 297428 308757 501550 292074 309678 290659 362237 367252 295319 56082 25081 100126191 295394 362504 298452 287523 29167 680594 362191 81655 29564 290798 84428 29144 116659 140734 308961 292090 299850 79214 305073 302470 81756 363104 117103 81750 64312 406161 58935 103689965 296121 84478 171329 54225 501659 304150 85471 290864 310960 311807 288482 289717 308669 309595 360860 290631 25490 316794 246310 306570 287444 314644 288923 310261 171102 294790 290997 362704 303539 308896 314453 314949 302488 100910107 297989 100912059 298247 60371 360819 307905 313427 117519 310306 291796 292876 291095 78971 293587 361381 307848 361373 300036 315134 362414 304579 100361658 293570 266601 63996 114558 24176 29486 60331 312688 192152 310935 303201 362636 100911225 313304 303351 315958 687696 408217 309512 361015 688466 171565 363084 311856 361190 302415 100190936 499801 309153 363164 290794 312937 689730 287362 24825 25388 311030 498798 296290 84577 309995 501145 313961 297561 25094 299957 64520 316164 500545 114592 83422 362965 367152 293733 29251 315713 287662 293967 362827 361645 83614 64550 499179 64041 362280 363287 114031 29417 298296 296099 289468 311786 65165 24268 114489 116510 364398 291983 289560 171154 24765 296304 500367 24946 84430 308440 680076 25434 294241 289990 315745 290692 54279 362934 303635 293721 58854 117522 313488 499016 29425 170818 100910410 116658 79112 300060 300950 300948 305895 315108 79110 300017 64202 300025 296627 63878 287983 29750 503446 29675 685860 541462 29671 362862 363464 29670 503164 691259 60378 24968 680210 24967 300772 303792 192263 690914 305792 306073 29666 316131 308807 117263 363455 117262 171129 100911548 362031 364814 299266 290206 56646 65044 292845 299208 312806 310982 161475 309686 311039 302931 311836 83499 83501 305235 499751 24244 365277 689197 102553119 305626 29614 313348 29211 59302 689852 29403 415062 361664 289831 291212 361268 338474 362547 313878 304920 289257 293129 499972 362762 100911374 29668 360622 498992 304917 64456 292766 362756 102554393 25685 297592 310670 289085 304571 313445 25277 304334 25295 84019 81827 367083 303602 304794 25285 296368 360838 117537 367785 293719 100360475 315075 360475 317381 295382 690037 366478 24242 363259 314273 363060 29630 100909521 100909524 296651 408248 314457 688993 688673 363284 361187 64366 295051 498272 25373 298541 83505 298071 293345 171152 307821 310710 302972 311847 502017 312826 29758 296394 25615 114711 311530 302915 296370 29640 304860 300741 297393 303692 81759 300089 304543 25280 294400 296624 360518 299346 304954 407765 407764 498486 287920 85492 301155 297417 116643 116696 501167 364901 363109 362415 100910143 361368 361634 315000 316628 313770 303311 291132 64462 287054 313743 364050 116597 302981 85237 290279 287706 313233 302288 313231 364032 287716 306608 289181 313020 60333 315807 289525 687364 313242 315222 305351 681194 302499 499260 292485 313038 305614 362581 309626 304850 117044 303730 303731 78965 501403 310258 316614 24177 307151 312690 362093 303024 25493 89820 500616 298534 24498 83712 89829 305451 102551184 53372 294429 29240 300259 299706 303874 680097 114521 292085 117021 304862 295277 100912489 364723 58958 245922 113929 65274 287830 25573 102548682 116555 103689978 308384 362281 78973 65026 25281 100360950 300193 683983 308508 679900 295692 500351 291874 81738 499974 679983 113975 360967 102557184 25497 362335 407784 362912 54226 100361647 362133 79434 300445 64515 315287 314352 315879 307893 79224 25506 688813 114589 79210 311202 25586 303743 361831 64043 353227 362567 362566 24571 311169 103694910 360928 65158 291912 500262 286976 311633 362902 364227 113910 362891 353251 83725 84595 303702 288038 498005 361749 29160 313121 288041 691120 103694000 500133 207126 297504 362182 24259 498034 303886 294862 316228 207113 100909827 252916 307200 303244 685758 24210 361765 298692 81716 298683 260320 315139 316976 311245 60373 306549 287159 83627 288238 502308 83681 100910771 683206 81830 689404 314855 362356 54237 309035 292905 316091 500221 378774 83476 302666 300668 315212 171459 315405 309051 307838 116740 287280 293060 25376 24832 306886 300653 293705 292124 500572 292325 690512 309295 293023 303755 690367 29461 363982 301013 100360606 361014 362491 24205 288692 315911 310324 286761 170501 363599 500050 362788 84508 310677 SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME DATABASE ID RELEASE 60%9438190 Synthesis of dolichyl-phosphate mannose 502017 296394 29640 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME DATABASE ID RELEASE 60%9438791 Interleukin-3, 5 and GM-CSF signaling 291983 171109 24514 246145 289924 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 58854 102552659 170668 29425 65179 24408 25167 64030 24716 24410 24412 117281 24446 498576 29675 29671 29670 29376 24968 24967 29372 690919 25704 112400 29666 24337 24329 117263 117262 116663 364814 290206 24592 103694903 64022 161475 360814 24703 83499 24245 24244 25267 309179 29614 29496 295234 29211 689852 64363 24497 652957 116630 140924 114103 24246 303353 289257 84423 84422 29668 29495 25614 292766 691318 25266 362572 360573 60427 24672 309168 365388 81827 24673 288924 171081 24242 94198 291245 296072 29630 81511 296651 408248 304893 24586 25746 116590 307821 50689 85492 83613 312754 300980 66023 25525 25326 314612 305203 312664 25136 432361 287716 114858 58960 192126 29542 192213 25467 192117 364052 246150 315648 305614 299147 288589 25400 25150 59323 25344 171140 84598 170577 59325 25433 25676 310533 366508 500985 64156 116689 50522 25734 25581 287942 89807 89804 85243 83805 681260 64159 498837 100912032 362045 56011 84477 79114 81504 170633 25513 83806 170700 313845 54250 287670 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 25114 25022 29368 116499 25622 60662 85385 170582 84492 24525 66017 25156 60464 29669 54259 24918 54245 100911248 29677 63881 29672 81515 287772 287984 311078 SELENOCYSTEINE SYNTHESIS%REACTOME DATABASE ID RELEASE 60%9439046 Selenocysteine synthesis 64640 79049 500255 ISG15 ANTIVIRAL MECHANISM%REACTOME%R-RNO-1169408.1 ISG15 antiviral mechanism 100912571 501116 688288 361628 298573 25124 116725 300756 292892 117045 25738 301000 295704 306204 287436 84598 363275 367264 297481 50689 312688 298693 24667 303831 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME%R-RNO-433137.1 Sodium-coupled sulphate, di- and tri-carboxylate transporters 64846 503568 65202 58980 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME DATABASE ID RELEASE 60%9438895 Cross-presentation of soluble exogenous antigens (endosomes) 291983 289924 29614 29669 502852 689852 289990 303353 58854 307821 287716 29425 29668 292766 83806 295279 29677 287670 29672 29675 365388 29671 81827 29670 24968 25581 24967 287772 29666 287984 117263 311078 117262 364814 290206 94198 29630 296651 161475 408248 85492 83499 PTK6 REGULATES CELL CYCLE%REACTOME DATABASE ID RELEASE 60%9439272 PTK6 Regulates Cell Cycle 366275 83571 94201 58919 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 60%9438236 Toll Like Receptor 2 (TLR2) Cascade 303024 116590 25493 689314 363855 314322 81771 308267 363520 64156 291912 498003 296390 50689 25272 117281 314384 313121 287398 50522 500133 100912585 679539 315305 305549 114509 81647 301059 81649 362418 305451 305835 116663 100363500 309361 361765 289014 81646 103694903 309165 315139 311245 84351 114495 100910771 317546 50658 361565 300980 300447 100912399 116596 116667 303200 315994 100912618 681260 501560 116554 24516 362356 81722 287707 24672 309452 24673 498837 315648 117269 116725 100912032 287280 309295 81736 362491 25742 60587 305751 309957 81525 304859 54226 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME DATABASE ID RELEASE 60%9438177 Removal of aminoterminal propeptides from gamma-carboxylated proteins 81750 306608 25295 58935 24946 260320 54281 29251 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%R-RNO-193648.1 NRAGE signals death through JNK 310738 246217 64547 140898 310460 361223 78966 84009 310635 361921 303634 64639 24225 363509 81737 307098 25730 296603 304109 687105 114559 117020 84469 293024 100362710 116554 29491 292750 363460 310192 85384 301334 313845 310999 362648 304193 24596 290541 311647 309653 295378 363875 25156 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%R-RNO-532668.1 N-glycan trimming in the ER and Calnexin Calreticulin cycle 364398 499751 300445 315000 296304 314352 29144 293721 681260 64156 362891 64202 303702 289085 50522 297504 498837 360967 294862 293719 100912032 298012 304543 117263 288702 171129 407784 362912 361014 116643 84508 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME%R-RNO-418592.1 ADP signalling through P2Y purinoceptor 1 89788 81649 81662 24400 24653 81666 309242 83805 25265 CS DS DEGRADATION%REACTOME%R-RNO-2024101.1 CS DS degradation 29139 294673 50568 114122 25393 81651 367166 58982 25181 360904 300757 25227 XENOBIOTICS%REACTOME DATABASE ID RELEASE 60%9437980 Xenobiotics 24297 24303 24300 25086 54246 29295 25053 286953 25243 25242 25690 286963 100910877 171522 171352 361523 252931 100361492 685222 25642 100910127 499353 292728 24296 266684 103691072 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 60%9438603 Mitotic Prometaphase 304740 499933 117281 25203 304218 314949 103694903 63996 290577 29486 305343 313304 315958 294429 299706 309179 292085 85252 287830 116555 691318 683983 81738 24672 24673 297176 171576 64515 680006 361662 307641 116549 301701 298594 286993 308443 100911204 362548 500545 114592 362965 293733 681050 317252 81650 64041 684439 294712 304951 304477 65201 298850 501706 312754 287598 363028 363174 362044 691493 289150 171529 305270 287624 83572 64465 361416 24669 315164 295661 684771 311191 291441 681185 295107 25448 362519 305392 54237 363481 316425 296137 257649 83836 257644 315648 114764 299147 170845 29648 307805 498310 114514 84391 311327 362186 306464 360886 297522 303037 363059 TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME DATABASE ID RELEASE 60%215126 Transport of connexins along the secretory pathway 24392 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 60%9438625 ATF6 (ATF6-alpha) activates chaperones 302705 304962 89842 SYNTHESIS OF PS%REACTOME DATABASE ID RELEASE 60%9438956 Synthesis of PS 293620 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME DATABASE ID RELEASE 60%9439132 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 296883 59294 287524 81709 499505 289758 361698 59102 81513 100911727 LINOLEIC ACID (LA) METABOLISM%REACTOME%R-RNO-2046105.1 Linoleic acid (LA) metabolism 498728 679532 363516 25288 84575 309449 171400 RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 60%9439095 RIPK1-mediated regulated necrosis 266610 246775 25385 246097 117279 311786 60371 246756 78971 306886 690743 246240 64044 MAPK3 (ERK1) ACTIVATION%REACTOME%R-RNO-110056.1 MAPK3 (ERK1) activation 24514 25622 84598 50689 25205 24498 54237 LACTOSE SYNTHESIS%REACTOME DATABASE ID RELEASE 60%9439171 Lactose synthesis 24390 24778 24528 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 60%9437998 Beta oxidation of octanoyl-CoA to hexanoyl-CoA 113965 170670 171155 24158 100911186 140547 BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 60%9438551 Breakdown of the nuclear lamina 60374 116685 83584 103689977 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-RNO-975144.1 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation 363520 100912618 305835 309361 309295 679539 296390 311245 305549 84351 116725 REGULATION OF IFNA SIGNALING%REACTOME DATABASE ID RELEASE 60%9438837 Regulation of IFNA signaling 690894 298205 288264 502965 24697 25124 100912356 502966 686326 298211 502962 298210 24481 100361294 500491 25622 116689 84598 367264 288774 312688 100911527 103690314 100912314 INTERLEUKIN-20 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 60%9438770 Interleukin-20 family signaling 500836 501043 170819 308716 304091 362629 681112 444986 681145 CLEARANCE OF NUCLEAR ENVELOPE MEMBRANES FROM CHROMATIN%REACTOME%R-RNO-2993913.1 Clearance of Nuclear Envelope Membranes from Chromatin 25437 114087 362779 DISINHIBITION OF SNARE FORMATION%REACTOME DATABASE ID RELEASE 60%9438111 Disinhibition of SNARE formation 114095 24680 25023 24681 81803 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME%R-RNO-74751.1 Insulin receptor signalling cascade 291983 26954 171109 24514 246145 289924 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 58854 102552659 170668 29425 65179 24408 25167 64030 24954 64562 287871 24716 24506 24410 24505 24412 56718 117281 24446 301518 498576 29675 298514 29671 29670 29376 24968 24967 29372 690919 25704 112400 29666 24337 24329 117263 117262 116663 364814 290206 24592 103694903 246273 64022 161475 308869 60445 360814 24703 64226 83499 24245 24244 338457 25267 309179 29614 29496 295234 29211 689852 64363 24497 652957 116630 140924 114103 24246 303353 24855 289257 84423 361992 84422 29668 81745 303605 29495 25614 292766 691318 25266 363131 362572 310091 360573 60427 24672 309168 365388 81827 24673 292887 288924 171081 24242 291245 94198 296072 29630 81511 296651 408248 297960 304893 24586 25746 301574 116590 307821 50689 100912571 116636 85492 25233 300253 83613 290291 312754 83803 24185 29516 65248 300980 66023 25525 25326 360776 314612 305203 312664 25136 65052 432361 287716 114858 58960 501146 192126 29542 192213 83840 25467 192117 295357 364052 246150 315648 305614 117045 299147 78975 288589 25400 25150 100909655 117044 59323 25344 171140 84598 170577 117043 59325 25433 25435 25676 310533 64156 50522 25581 89807 29741 89804 85243 83805 681260 64159 100361543 498837 100912032 362045 56011 79114 81504 170633 25513 83806 170700 313845 287670 54250 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 361388 25114 25022 29368 116499 25622 60662 85385 170582 24525 66017 60464 498416 29669 29677 29672 287772 287984 311078 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME DATABASE ID RELEASE 60%9438788 Activation of kainate receptors upon glutamate binding 29322 24244 25252 24654 24400 24407 298521 553106 29559 24242 54257 29495 58948 CREATION OF C4 AND C2 ACTIVATORS%REACTOME%R-RNO-166786.1 Creation of C4 and C2 activators 299354 114091 192262 100911854 64668 29687 366588 64023 312705 298566 299928 64459 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 60%9438627 PERK regulates gene expression 54318 29702 NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME DATABASE ID RELEASE 60%9437850 Neurotransmitter uptake and metabolism In glial cells 170567 24957 29483 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 60%9438569 Na+ Cl- dependent neurotransmitter transporters 171148 29503 664630 117100 113918 50676 24898 298340 282712 79213 83511 79212 171163 29464 116509 29323 25693 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%R-RNO-977068.1 Termination of O-glycan biosynthesis 24571 64442 362924 207126 407764 25197 303886 64445 690914 303692 363040 PREGNENOLONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 60%9438420 Pregnenolone biosynthesis 24230 25557 287609 313786 363675 24192 291182 79122 29189 TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME DATABASE ID RELEASE 60%9439229 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 361181 171150 289561 294693 116468 497967 304343 288003 103690054 245976 298508 364834 361365 303369 287367 363283 312710 25737 84389 64156 292778 690966 289758 261736 301382 59102 363273 308415 288651 50522 691642 502227 362394 246216 314061 117017 89809 83503 298074 360471 81513 291703 362479 681260 498109 100361574 304528 366163 64470 100911295 292673 59294 363633 300084 287524 310071 498837 266713 361698 100912032 360915 296883 84495 306274 360704 100912534 294236 302502 288414 498453 361580 100911727 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME%R-RNO-156988.1 Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor 84010 311332 56761 406162 29146 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%R-RNO-3270619.1 IRF3-mediated induction of type I IFN 499069 498840 299827 292545 293774 292892 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 60%9438154 L13a-mediated translational silencing of Ceruloplasmin expression 64156 299872 100360057 367195 100360619 100911847 81729 681260 291615 498837 100912032 103692785 140655 362952 287417 360572 292964 367865 103690821 100912571 367265 100910180 294282 29236 100360647 100911575 140662 100364265 100360841 103690015 684988 691531 295975 140661 64640 29283 29284 103692831 28298 287436 100360679 26962 64302 302697 103693375 290641 689284 362041 300253 100360117 296709 103694404 296302 317646 29288 81767 29282 81763 100360522 81768 81765 81769 64205 288599 311120 301299 100362830 292148 690468 314652 81775 293427 81770 29752 64638 81776 292762 299027 25348 300069 306079 103694169 293484 288516 65139 297756 100912182 300079 298700 117045 25347 682793 100910370 685963 124440 306926 691947 687780 29258 54318 100911110 100359922 161477 65043 25538 499782 100361079 303831 SEPARATION OF SISTER CHROMATIDS%REACTOME%R-RNO-2467813.1 Separation of Sister Chromatids 291983 289924 304740 289990 58854 29425 64156 499933 117281 304218 314949 29675 50522 29671 29670 24968 25581 24967 29666 117263 117262 364814 290206 103694903 63996 290577 29486 161475 305343 313304 315958 83499 294429 299706 309179 29614 292085 689852 303353 681260 85252 287830 29668 116555 292766 691318 683983 81738 24672 365388 81827 24673 498837 297176 296368 360643 498030 100912032 305420 293155 94198 29630 296651 408248 171576 290875 361389 64515 680006 296558 291689 366381 311412 100360936 361831 304490 361662 307821 83806 301701 287670 298594 286993 308443 100911204 362548 500545 114592 362965 293733 681050 317252 64041 684439 85492 294712 304951 304477 65201 298850 501706 312754 287598 363028 363174 29669 362044 691493 289150 171529 305270 315330 287624 64193 83572 361416 24669 315164 295661 684771 287716 311191 291441 681185 25448 316425 363481 29677 296137 29672 257649 83836 257644 287772 315648 114764 299147 287984 170845 29648 307805 311078 498310 114514 311327 84391 362186 306464 360886 297522 303037 363059 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME%R-RNO-918233.1 TRAF3-dependent IRF activation pathway 292892 24481 54244 DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 60%9439296 DNA Damage Reversal 291905 303193 SYNTHESIS OF PI%REACTOME%R-RNO-1483226.1 Synthesis of PI 192260 287467 361694 81925 304474 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%R-RNO-109606.1 Intrinsic Pathway for Apoptosis 29748 64547 492821 25402 246142 313017 29753 25576 64625 298795 56011 56010 64639 25309 140734 24224 25577 171378 116554 64044 100363502 78963 58918 259274 266704 502003 100360940 64026 171290 171528 691670 691695 100361468 116502 691668 100361261 288753 103690372 24887 100911163 TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME DATABASE ID RELEASE 60%9438925 TWIK-releated acid-sensitive K+ channel (TASK) 84429 29553 DISSOLUTION OF FIBRIN CLOT%REACTOME%R-RNO-75205.1 Dissolution of Fibrin Clot 85253 56611 81778 25692 50692 60325 171016 25619 24617 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 60%9438547 Acetylcholine Neurotransmitter Release Cycle 85426 64832 362876 293645 290567 64830 116470 287609 140592 140591 25531 84556 25558 24803 25716 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%R-RNO-606279.1 Deposition of new CENPA-containing nucleosomes at the centromere 298850 680097 289150 295277 305270 100912489 310511 364723 361416 315164 102548682 681185 316602 25448 100360950 500351 689399 681382 100911204 307766 679983 83712 689296 362548 102557184 65137 307805 311327 306464 684439 294712 313048 102551184 INTRAFLAGELLAR TRANSPORT%REACTOME DATABASE ID RELEASE 60%9439154 Intraflagellar transport 303968 170714 314523 309126 300062 313365 100362124 685284 499814 140734 288585 298767 503018 361415 363286 287541 312651 373066 314393 300675 299209 363544 500571 362265 500086 295106 295654 305918 305349 84392 289168 296284 85248 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 60%9438147 Regulation of mitotic cell cycle 291983 171576 290875 361389 114851 64515 83571 289924 296558 291689 366381 114482 289990 311412 100360936 292263 361831 310806 304490 361662 58854 307821 29425 64156 83806 294790 25203 287670 29675 295052 50522 29671 29670 24968 114592 24967 25581 29666 117263 117262 364814 361765 290206 362817 161475 85492 114494 83499 29614 29669 689852 64193 303353 681260 287716 690209 29668 292766 314642 362356 54237 29677 29672 365388 81827 498837 297176 261730 296368 360643 287772 498030 287280 100912032 305420 287984 293155 311078 94198 29630 296651 408248 CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME%R-RNO-5620920.1 Cargo trafficking to the periciliary membrane 85258 64632 363272 252881 60627 24650 171455 116654 309156 103690077 81830 117103 363760 171044 299246 309451 362142 361930 315484 316102 300754 305287 25411 83686 114089 304037 79120 50556 113948 245709 100911734 EXTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 60%9438132 Extrinsic Pathway of Fibrin Clot Formation 24946 29436 260320 25584 RESPONSE TO METAL IONS%REACTOME DATABASE ID RELEASE 60%9439195 Response to metal ions 117038 SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME%R-RNO-3232118.1 SUMOylation of transcription factors 296099 83614 25094 64520 25573 83422 300772 301442 362280 367152 499417 362827 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-RNO-75955.1 RNA Polymerase II Transcription Elongation 303132 266787 304832 171150 289561 301119 294693 311796 25562 316123 305851 294258 287608 293184 103690054 306261 306347 364834 81785 361365 305455 303281 291705 81674 300837 84389 292778 689116 690966 366169 304758 308415 288651 502227 117017 362110 64525 81807 83503 315291 291703 298075 362479 498109 100361574 500715 308472 363633 266713 363064 100912534 294236 498453 361531 361580 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME DATABASE ID RELEASE 60%9439231 Gap-filling DNA repair synthesis and ligation in TC-NER 361181 171150 289561 294693 116468 497967 288003 103690054 245976 298508 364834 361365 303369 25737 84389 64156 292778 690966 289758 59102 308415 288651 50522 691642 502227 362394 246216 314061 117017 89809 83503 360471 81513 291703 362479 681260 498109 100361574 304528 366163 64470 100911295 59294 363633 300084 287524 310071 498837 266713 361698 100912032 296883 84495 306274 360704 100912534 294236 302502 288414 498453 361580 100911727 DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 60%9439147 Dectin-1 mediated noncanonical NF-kB signaling 291983 303024 289924 289990 58854 307821 29425 64156 83806 117553 287670 360640 29675 50522 29671 29670 24968 25581 24967 100360982 29666 361509 117263 117262 364814 309361 290206 361765 161475 85492 83499 29614 29669 689852 303353 681260 287716 29668 292766 362356 29677 29672 365388 81827 309452 498837 287772 100912032 287280 287984 311078 94198 29630 296651 408248 NGF PROCESSING%REACTOME DATABASE ID RELEASE 60%9438245 NGF processing 310738 116548 25507 54281 G1 S DNA DAMAGE CHECKPOINTS%REACTOME%R-RNO-69615.1 G1 S DNA Damage Checkpoints 314856 291983 362485 304798 114851 100910954 83571 25729 289924 289990 58854 360860 307821 29425 64156 171102 83806 287670 29675 295052 50522 29671 29670 24968 25581 24967 29666 117263 117262 364814 290206 114212 362817 161475 85492 300711 311575 114494 83499 29614 29669 689852 303353 681260 287716 29668 292766 29677 29672 365388 81827 685474 498837 287772 100912032 287984 311078 94198 29630 296651 408248 PEROXISOMAL LIPID METABOLISM%REACTOME%R-RNO-390918.1 Peroxisomal lipid metabolism 85255 300083 311849 296138 79244 252898 83842 83522 114209 170588 291076 85239 65192 307170 361413 65183 291075 679565 681337 24157 84029 308518 25284 363516 299193 171142 50681 100910957 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-RNO-176409.1 APC C:Cdc20 mediated degradation of mitotic proteins 291983 171576 290875 361389 64515 289924 296558 291689 366381 114482 289990 311412 100360936 361831 304490 361662 58854 307821 29425 64156 83806 25203 287670 29675 295052 50522 29671 29670 24968 24967 25581 29666 117263 117262 364814 290206 161475 85492 114494 83499 29614 29669 689852 64193 303353 681260 690209 287716 29668 292766 54237 29677 29672 365388 81827 498837 297176 296368 360643 287772 498030 100912032 305420 293155 287984 311078 94198 29630 296651 408248 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%R-RNO-901032.1 ER Quality Control Compartment (ERQC) 364398 499751 315000 296304 50522 314352 297504 498837 360967 294862 100912032 681260 171129 407784 64156 362891 84508 289085 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 60%9438596 Semaphorin interactions 25418 116671 361597 313494 25416 246331 25417 362398 25415 65208 309280 78966 301227 64373 314641 361568 102552659 366957 29432 65172 299331 81762 316009 301252 297173 25537 361537 296789 315711 100910732 363517 24337 313498 29431 312652 29433 310207 25150 311384 306400 289392 316639 362993 140908 29751 363875 306790 308875 EPHB-MEDIATED FORWARD SIGNALING%REACTOME DATABASE ID RELEASE 60%9439101 EPHB-mediated forward signaling 288669 360854 682507 84009 64465 83805 304109 24408 289820 25614 287876 29491 24410 81762 297173 81515 25615 293621 25537 81822 306636 297518 25186 361882 24338 287989 29431 25150 360546 54227 81732 100361457 363875 24884 25676 684969 FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 60%9438391 FGFR1c and Klotho ligand binding and activation 79114 170583 GAP JUNCTION ASSEMBLY%REACTOME%R-RNO-190861.1 Gap junction assembly 29584 394266 266706 24392 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%R-RNO-438064.1 Post NMDA receptor activation events 24245 24244 83613 116590 81771 24246 361568 25050 317203 501560 305509 60341 24408 81745 29495 64508 293508 24410 24412 192213 293621 246150 117269 29241 25400 24242 100363500 291245 171140 81646 24703 ANDROGEN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 60%9438422 Androgen biosynthesis 25329 117182 29632 360348 116700 100911154 305291 24664 24950 64677 INTRA-GOLGI TRAFFIC%REACTOME%R-RNO-6811438.1 Intra-Golgi traffic 65134 116500 60355 314393 690407 64154 367308 690961 313493 500906 309306 60562 64516 64351 116691 310526 140673 116693 116692 116639 315668 299258 308821 310411 365793 361407 94189 24197 361073 303652 293456 100359675 64310 291990 MICRORNA (MIRNA) BIOGENESIS%REACTOME DATABASE ID RELEASE 60%9438529 MicroRNA (miRNA) biogenesis 311130 363006 299284 59117 N-GLYCAN ANTENNAE ELONGATION%REACTOME DATABASE ID RELEASE 60%9438868 N-Glycan antennae elongation 65196 25547 24390 313536 367252 494342 362275 303923 25197 65271 363040 303100 LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME%R-RNO-418889.1 Ligand-independent caspase activation via DCC 25402 25311 290537 58918 TNFR1-INDUCED NFKAPPAB SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 60%9439128 TNFR1-induced NFkappaB signaling pathway 313121 100910771 683206 317546 311786 246756 60371 306886 308267 78971 83427 361373 103694380 60383 687813 309295 309361 315139 364386 84351 312937 81859 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME%R-RNO-350562.1 Regulation of ornithine decarboxylase (ODC) 291983 289924 29614 24314 29669 689852 24609 289990 501454 303353 58854 307821 287716 29425 29668 292766 58961 83806 29677 287670 29672 29675 365388 29671 81827 29670 24968 25581 24967 287772 29666 287984 117263 311078 117262 364814 94198 290206 29630 689588 296651 161475 408248 25502 85492 83499 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%R-RNO-204998.1 Cell death signalling via NRAGE, NRIF and NADE 64547 25402 29753 64639 64156 113894 29491 313845 24596 50522 362548 289231 311245 363875 25156 310738 246217 140898 310460 64314 361223 78966 84009 310635 361921 303634 24225 363509 81737 307098 296603 681260 25730 304109 687105 117089 114559 117020 84469 293024 100362710 116554 292750 363460 310192 85384 301334 310999 362648 304193 290541 311647 498837 309653 295378 100912032 100911293 300802 691658 81751 365872 292788 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-RNO-975957.1 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 64156 117281 100360057 367195 100360619 100911847 81729 103694903 287113 365215 298075 24420 100911685 684558 681012 360855 307503 100125373 361176 681260 291615 287522 501582 287596 688288 24672 498837 100912032 298385 117104 103692785 140655 287417 360572 313449 292964 367865 689116 103690821 100912571 367265 100910180 294282 690303 29236 100360647 100911575 140662 100364265 100360841 103690015 684988 691531 140661 295284 361109 64640 29283 29284 103692831 28298 100360679 26962 64302 103693375 290641 689284 362041 100360117 296709 103694404 317646 29288 81767 29282 81763 100360522 81768 81765 81769 64205 311120 301299 100362830 690468 314652 81775 81770 29752 64638 81776 25348 306079 103694169 65139 297756 100912182 300079 25347 682793 100910370 685963 124440 306926 687780 29258 100359922 161477 65043 25538 499782 100361079 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 60%9438208 G alpha (s) signalling events 25360 171519 25238 25369 54223 25447 25449 65032 56820 305509 292661 25616 498475 25726 25040 64508 84420 24241 338443 56813 140928 688730 140929 29555 24952 25461 29241 140595 24176 25477 499486 65275 25108 24316 25026 24166 25024 24769 25310 60432 25329 171158 29446 81744 117257 399475 366668 25638 309962 29691 363993 24626 81743 29316 290646 59076 25387 59075 29310 25388 25029 24627 116700 24664 81752 81753 24400 295144 58965 81648 25645 24476 58966 499149 288181 58959 24221 308776 24694 25195 24953 25635 29516 100360071 282839 103694905 25289 25051 64532 114215 117064 81779 266997 25321 363866 25324 302950 64680 25653 301372 63885 64354 63889 50678 FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME DATABASE ID RELEASE 60%9439287 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 291983 289924 289990 58854 307821 29425 64156 100359528 83806 287670 29675 50522 29671 29670 24968 25581 24967 678726 29666 117263 117262 364814 290206 161475 85492 83499 29614 361907 29669 689852 303353 681260 287716 29668 292766 362356 29677 29672 300084 365388 81827 498837 261730 287772 100912032 287280 287984 311078 94198 29630 296651 408248 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%R-RNO-73929.1 Base-Excision Repair, AP Site Formation 315344 29541 114521 367090 81528 305957 680915 304577 24561 170841 CYP2E1 REACTIONS%REACTOME%R-RNO-211999.1 CYP2E1 reactions 25086 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME%R-RNO-1280215.1 Cytokine Signaling in Immune system 690894 289924 25235 24684 686326 24683 24481 25069 305896 306204 359726 171369 25008 296872 100911527 301133 301132 500318 100912356 300756 24283 295704 170538 363275 288774 498666 100912314 298205 361628 295234 24391 298211 298210 303353 298693 365581 498206 361677 288264 365388 502965 502966 89814 502962 353218 94198 366518 25572 25126 24667 25341 297604 116590 25402 50689 100912571 287436 89817 297481 302965 501116 500592 500590 361390 298573 287034 117045 103694381 103689974 103690314 303831 116689 60371 24697 25581 78971 312688 64159 498769 500910 362045 360548 156767 84349 500491 683163 83806 287670 81649 302424 29669 103694380 29677 29672 311786 287772 287984 311078 81736 291983 171109 24514 246145 246144 24628 24629 293847 313874 25453 289990 25597 292892 314596 29434 364686 116562 58854 102552659 170668 29425 65179 24408 25167 64030 24716 24410 24412 117281 24446 498576 29675 29671 29670 29376 360697 24968 117063 24967 300772 29372 690919 252971 116465 25704 112400 29666 24337 24329 117263 117262 116663 364814 290206 25712 24592 103694903 64022 161475 360814 24703 83499 24245 24244 25267 309179 29614 29496 29211 689852 64363 24497 652957 116630 140924 114103 24246 289257 84423 84422 29668 29495 25614 292766 691318 25266 362572 360573 60427 688288 24672 309168 81827 24673 288924 171081 24242 291245 296072 29630 81511 296651 408248 304893 24586 25746 307821 117553 360640 100360982 85492 83613 312754 300980 66023 25525 25326 314612 305203 312664 25136 432361 287716 114858 58960 192126 29542 192213 25467 192117 364052 246150 315648 305614 299147 288589 25400 25150 59323 25344 171140 84598 170577 59325 25433 25676 310533 117539 303024 296541 366508 303604 116470 500985 25493 689314 362896 311783 301442 245983 363855 314322 81771 689932 308267 500616 363520 25610 288905 113894 64156 100360218 171060 498003 155140 296390 25272 24498 171040 691516 81803 24494 24493 29201 81802 287398 50522 314870 25734 100912585 309157 315305 89829 305549 114509 301365 81647 301059 361509 100361294 297520 305451 287942 685840 309361 289014 81646 309165 29197 290655 84351 89807 89804 85243 287437 83805 681260 300084 498837 116725 100912032 56011 25325 84477 252963 308716 291912 681112 79114 81504 170633 25513 170700 313845 314384 24500 54250 361749 25443 313121 25444 170579 310132 316213 304091 293621 500133 688622 314850 679539 25317 170583 25124 29348 81680 29349 444986 84489 171334 171333 24605 25125 25114 304061 25738 25663 25670 25022 29368 362418 116499 305835 25622 100363500 60662 361765 85385 362629 170582 362628 84492 315139 311245 25205 362417 25155 24525 66017 114495 60464 25156 116558 501043 171379 100910771 317546 25466 50658 24932 361565 365395 54259 116596 303200 25556 681145 289747 315994 301000 24918 100912618 312679 501560 171106 54245 291159 116554 367264 24516 116553 362356 25166 54237 100911248 287287 63881 170819 294797 81515 300177 309452 680609 301289 501996 682457 691496 117269 287280 50646 116996 313173 500836 25707 362076 362077 309295 25084 298518 306247 307403 362491 64546 60587 309957 362788 84405 60584 AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME%R-RNO-450408.1 AUF1 (hnRNP D0) binds and destabilizes mRNA 291983 289924 289990 58854 307821 29425 64156 83806 100912571 287670 29675 50522 29671 29670 24968 25581 24967 29666 117263 117262 364814 290206 161475 85492 83499 29614 29669 689852 303353 681260 287716 291615 29668 292766 29677 689955 29672 365388 81827 498837 287772 100912032 24471 287984 311078 94198 29630 296651 408248 79256 PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 60%9437926 Programmed Cell Death 29748 307562 64547 492821 25402 83502 246142 291755 313017 29753 291752 25576 64625 298795 56011 56010 64639 24224 25577 298534 171378 64044 83527 367786 316164 60371 259274 266704 78971 502003 100360940 64026 171290 170538 171528 691670 85420 691695 100361468 116502 296654 691668 100361261 24917 288753 103690372 100911163 499156 29477 288064 305884 501266 29395 60374 116685 293852 317589 83584 298282 114214 25318 64204 498988 171116 24170 498072 114114 81818 361092 25309 140734 25311 116554 25614 690743 64159 246240 103689977 290537 100363502 78963 81762 58918 266610 246775 25385 246097 117279 311786 246756 306886 24205 24887 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME%R-RNO-112297.1 Post-Elongation Processing of Intronless pre-mRNA 116697 687711 314417 298075 680737 171365 683927 311166 299256 689116 298916 292683 304277 366952 291877 307524 681031 311670 309338 365407 100360682 361605 687679 501688 366468 292884 681062 PROLACTIN RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 60%9438870 Prolactin receptor signaling 24514 25235 300084 24684 24391 89817 24683 287280 24283 24918 25622 361765 25126 362356 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 60%9438780 activated TAK1 mediates p38 MAPK activation 313121 100910771 317546 500133 679539 689314 303200 116725 308267 315994 81649 362418 363520 100912618 309295 291912 289014 315139 296390 362491 311245 114495 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-RNO-111932.1 CaMK IV-mediated phosphorylation of CREB 24244 25050 24242 100363500 81646 REGULATION OF TP53 EXPRESSION%REACTOME DATABASE ID RELEASE 60%9439254 Regulation of TP53 Expression 100910954 IGF1R SIGNALING CASCADE%REACTOME%R-RNO-2428924.1 IGF1R signaling cascade 291983 26954 171109 24514 246145 289924 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 58854 102552659 170668 29425 65179 24408 25167 64030 64562 287871 24716 24410 24412 56718 117281 24446 301518 498576 29675 298514 29671 29670 29376 24968 24967 29372 690919 25704 112400 29666 24337 24329 117263 117262 116663 364814 290206 24592 103694903 246273 64022 161475 308869 60445 360814 24703 64226 83499 24245 24244 338457 25267 309179 29614 29496 295234 29211 689852 64363 24497 652957 116630 140924 114103 24246 303353 24855 289257 84423 361992 84422 29668 81745 303605 29495 25614 292766 691318 25266 363131 362572 310091 360573 60427 24672 309168 365388 81827 24673 24482 292887 288924 171081 24242 291245 94198 296072 29630 81511 296651 408248 297960 304893 24483 24586 25746 301574 116590 307821 50689 100912571 116636 85492 25233 300253 83613 290291 312754 83803 24185 29516 65248 300980 66023 25525 25326 360776 314612 305203 312664 25136 65052 432361 287716 114858 58960 501146 192126 29542 192213 83840 25467 192117 295357 364052 246150 315648 117045 305614 299147 78975 288589 25400 25150 100909655 117044 59323 25344 171140 84598 170577 117043 59325 25433 25435 25676 310533 64156 50522 25581 89807 29741 89804 85243 83805 681260 64159 100361543 498837 100912032 362045 56011 79114 81504 170633 25513 83806 170700 313845 287670 54250 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 361388 25114 25022 29368 116499 25622 60662 85385 170582 24525 66017 60464 29669 29677 29672 287772 287984 311078 OXYGEN-DEPENDENT ASPARAGINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%R-RNO-1234162.1 Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha 309434 29560 29452 CELLULAR RESPONSES TO EXTERNAL STIMULI%REACTOME%R-RNO-8953897.1 Cellular responses to external stimuli 291983 26954 289924 252902 289990 25242 58854 29425 64562 287871 56718 299331 301518 29675 298514 295052 29671 29670 24968 24967 29666 64345 308457 117263 117262 64525 81807 364814 24874 290206 29560 54702 362817 161475 308869 60445 300711 114494 64226 83499 24245 29614 295234 689852 316101 361258 24246 29452 24855 303353 29668 292766 363131 310091 365388 81827 296368 360643 498030 312647 305420 293155 292887 94198 29630 296651 408248 297960 314856 304798 114483 100910954 64012 116590 685055 310511 94167 307821 304063 94201 25261 50689 24356 292721 54238 25164 54244 301252 500904 85492 116643 308846 305831 365191 362504 29167 288498 83803 100359937 64670 65248 171415 81655 29564 360776 290798 84428 116659 312927 361916 65052 362164 140734 308961 363278 287716 364419 360827 299850 282834 303630 679886 64862 689161 58974 300240 59319 362245 24786 287873 313038 365057 315136 295357 363720 363254 361321 362809 688555 78975 362581 25400 309626 304850 100909655 293104 312299 117044 303730 303731 171140 116484 501403 498183 310258 117043 313048 114553 303259 363630 307151 312690 362485 114851 83571 25729 689314 363855 314322 81771 312634 64156 25272 59102 287398 50522 100912585 83712 25581 114509 24426 81920 289014 114558 102551184 53372 294429 64046 300259 299706 171361 100360868 680097 292085 85482 117021 304862 295277 100912489 117056 364723 58958 245922 113929 25309 65274 103693372 681260 287830 102548682 116555 362281 641452 25281 100360950 100363502 683983 295692 100361543 500351 291874 81738 499974 300084 679983 287524 113975 498837 367808 102557184 100912032 25497 362335 296883 117038 290875 361389 362045 58819 117254 25506 296558 29753 291689 366381 311412 100360936 361831 66021 304490 116686 83806 287670 113906 81649 114495 84581 297998 24787 293103 302935 297994 94165 65028 363849 286899 294408 50658 114490 690237 29669 100911837 85431 84026 293524 361403 303536 362078 303200 192277 103689963 500054 79462 315994 24248 690038 25420 305482 307861 100910067 501560 297758 84485 307798 291159 25154 116554 25352 361167 24516 314642 298376 361384 300721 361798 29677 290232 309434 689955 29672 287772 691496 117269 79129 287984 24963 103690404 311078 260321 362293 50551 361810 79245 81800 294744 304569 306007 171562 64371 24253 366734 288444 FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 60%9438381 FGFR1b ligand binding and activation 54250 25443 170579 79114 25317 170633 HIGHLY SODIUM PERMEABLE ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME%R-RNO-629587.1 Highly sodium permeable acetylcholine nicotinic receptors 25101 25590 29422 54240 25103 54239 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME DATABASE ID RELEASE 60%9438838 O-linked glycosylation of mucins 100361647 316583 288752 305571 362924 366061 308440 290638 363040 64043 313878 313233 24571 292090 79214 286976 302499 304571 29750 207126 25197 303886 690914 307838 303692 116740 100360475 292325 685758 64442 65044 407764 362275 64445 311039 83627 170501 PLATELET HOMEOSTASIS%REACTOME DATABASE ID RELEASE 60%9438118 Platelet homeostasis 54225 24400 140447 140448 282822 60395 292661 29693 29600 79113 140928 81649 25391 29715 24244 25679 25262 29516 24600 25310 24653 683667 24599 24598 25505 81739 308899 89788 81662 114115 29691 171115 497757 25206 89823 497963 66012 81666 25202 81743 25523 191569 24215 313611 29659 362558 113995 309242 29598 29665 29599 63885 24242 25041 50678 NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME%R-RNO-5675221.1 Negative regulation of MAPK pathway 171109 312754 309179 246145 116590 293847 300980 64363 56011 305203 681260 65179 64156 691318 50689 117281 360573 58960 29542 50522 24672 293621 24673 498837 315648 24605 100912032 299147 116663 103694903 170577 24525 24703 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 60%9437866 Cobalamin (Cbl, vitamin B12) transport and metabolism 362134 102554637 103690254 25052 408247 314459 81522 687861 80848 362653 362851 688517 64365 290947 683849 291939 362347 24691 313520 299196 246046 INTERACTION WITH CUMULUS CELLS%REACTOME%R-RNO-2534343.1 Interaction With Cumulus Cells 500052 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME%R-RNO-112296.1 Post-Elongation Processing of Intron-Containing pre-mRNA 116697 288701 314417 311166 313449 689116 361814 29667 291877 307524 308335 690303 309338 295284 362612 361605 313620 361542 362687 315170 290519 287113 361990 303057 361859 89827 298075 360845 362819 679894 305714 313308 360972 302729 689890 683927 299256 114612 500378 79227 298916 291797 292683 304277 494445 292007 687575 366952 688288 311670 365407 362264 298385 FATTY ACIDS%REACTOME%R-RNO-211935.1 Fatty acids 56266 24307 286904 503122 24306 266674 298423 290623 313375 50549 313373 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME DATABASE ID RELEASE 60%9438944 Acyl chain remodeling of DAG and TAG 100911615 302425 362972 84497 678749 252900 361676 29254 SYNTHESIS OF LIPOXINS (LX)%REACTOME DATABASE ID RELEASE 60%9439020 Synthesis of Lipoxins (LX) 287454 25290 79242 114097 29624 THE FATTY ACID CYCLING MODEL%REACTOME DATABASE ID RELEASE 60%9438224 The fatty acid cycling model 85263 25708 100909612 24860 54315 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 60%9438059 NGF signalling via TRKA from the plasma membrane 291983 171109 24514 246145 289924 246144 24628 25369 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 361696 58854 294048 102552659 64545 170668 84482 29425 65179 24408 25167 24954 64030 50686 59109 79240 24716 24506 24410 24505 24412 294235 56718 117281 84027 24446 498576 29675 294515 29671 365367 29670 59265 29376 24968 24967 29372 690919 25704 112400 29666 24337 24329 117263 310131 117262 116663 170538 364814 140607 290206 24592 103694903 246273 64022 161475 296648 360814 24703 64226 83499 24245 24244 25267 309179 29614 29496 29211 295234 689852 64363 24497 652957 116630 140924 114103 24246 295347 24855 303353 289257 84423 361992 84422 29668 81745 29495 25614 292766 691318 25266 362572 360573 60427 24672 309168 365388 81827 24673 365865 292887 288924 171081 24242 291245 94198 296072 29630 81511 296651 408248 304893 24586 25746 314856 116590 25050 307821 50689 81678 85492 25233 83613 312754 24185 300980 171574 66023 25525 25326 314612 305203 50557 312664 25136 432361 287716 114858 58960 192126 29542 29414 192213 25467 192117 364052 246150 315648 305614 81757 299147 288589 25400 25150 59323 25344 29622 171140 29613 84598 116478 170577 25054 59325 116546 300078 25433 294376 291713 25676 310533 114851 65046 83571 366508 25238 689314 54223 81771 314641 305509 64156 498003 64508 84420 29699 24679 50522 100912585 315305 24681 25581 114509 29241 287942 116563 309361 83800 140694 289014 25751 81646 89807 29741 310738 89804 85243 24166 83805 24680 681260 302415 64159 58918 308578 29691 498837 140670 100912032 54241 116743 309419 81637 362045 56011 79114 81504 170633 25513 89812 83806 170700 313845 314384 287670 54250 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 361388 25125 25114 25738 81649 25022 29368 116499 25622 100363500 60662 85385 170582 24525 66017 60464 25156 25679 25262 29669 361565 24225 25521 315994 81737 25730 25289 25725 501560 54245 64532 293508 56822 25636 100911248 25408 29677 25660 63881 29672 297173 302950 287772 117269 287984 311078 60587 309957 CAM-PDE 1 ACTIVATION%REACTOME DATABASE ID RELEASE 60%9438083 Cam-PDE 1 activation 24244 29691 24242 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME%R-RNO-71406.1 Pyruvate metabolism and Citric Acid (TCA) cycle 361596 80878 157074 117098 299201 25179 24368 29634 310378 170587 311254 114096 307852 81829 65200 29554 54705 24534 94173 24533 298942 363061 25682 296849 360975 116551 25246 25027 361071 289217 289950 362474 314196 81654 294320 301624 24439 25271 79250 81530 362404 89813 298596 SYNTHESIS OF PC%REACTOME%R-RNO-1483191.1 Synthesis of PC 290567 295417 363024 29367 296128 287644 307641 362261 116549 83817 313977 365962 316737 291793 298504 286936 361467 294255 362866 81650 310773 25511 293150 140544 29194 29510 TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME DATABASE ID RELEASE 60%9438924 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) 59324 100909725 499303 116491 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 60%9437928 Inactivation, recovery and regulation of the phototransduction cascade 24244 295500 25318 79222 301233 498869 316218 25539 499132 59077 363143 29481 83579 289878 680149 259274 688297 307401 116556 81760 291318 64511 24242 140936 317498 85259 83686 INWARDLY RECTIFYING K+ CHANNELS%REACTOME DATABASE ID RELEASE 60%9438878 Inwardly rectifying K+ channels 29712 29713 170847 25743 117052 24400 83633 25472 116560 276720 60449 81667 81657 114120 116649 114118 50599 114119 114117 79218 690825 680149 25560 245986 83535 25559 29719 INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME%R-RNO-499943.1 Interconversion of nucleotide di- and triphosphates 313560 362720 191575 102238592 58819 29261 303179 64045 497778 311833 171566 365985 682978 301622 619580 290741 85269 116484 29223 685579 116686 294521 299976 58964 PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME%R-RNO-8849469.1 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 366275 681260 50522 64156 24185 500985 498837 312477 361617 100912032 REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME%R-RNO-73943.1 Reversal of alkylation damage by DNA dioxygenases 291905 303193 SEROTONIN RECEPTORS%REACTOME DATABASE ID RELEASE 60%9438660 Serotonin receptors 103694905 25689 29581 64354 25323 29595 60448 25075 25324 24473 25187 65032 O-LINKED GLYCOSYLATION%REACTOME%R-RNO-5173105.1 O-linked glycosylation 100361647 315879 84430 308440 311202 299314 64043 362567 304135 24571 286976 29750 207126 25197 303886 690914 303692 685758 65044 407764 445442 306549 309686 311039 83627 316583 361368 288752 305571 362924 366061 100911750 290638 291212 363040 313878 313233 292090 79214 64456 102554393 310670 302499 304571 316091 307838 116740 100360475 292325 64442 114489 362275 64445 688673 170501 293667 EFFECTS OF PIP2 HYDROLYSIS%REACTOME DATABASE ID RELEASE 60%9438115 Effects of PIP2 hydrolysis 25666 25679 25262 89823 368088 100361138 282822 60395 140866 170538 361076 367745 85420 81821 309207 81749 304289 305795 499913 688705 29254 497978 54248 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 60%9438203 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 293114 296190 100912599 81728 299310 690441 499529 85263 295143 641434 315167 362749 94271 288088 245958 295923 301123 679739 25488 245965 292845 500350 299739 678759 299008 56769 293453 26201 25309 689271 293652 7066259 7066258 26203 7066257 26202 7066256 7066254 100363502 293655 100909612 289218 681418 690848 362588 362897 100363268 293448 297990 299643 100911417 303922 7066248 301458 497902 7066247 301427 362344 362495 316632 7066252 7066251 362810 29478 291660 25708 684509 26197 26196 293130 24860 54315 361385 26194 26199 26192 26193 301011 300677 293991 64539 140608 114630 300447 171082 299954 300726 171374 171375 296086 300047 680288 366448 192241 294973 298748 300091 294964 363441 100911483 29754 362837 362440 291103 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME DATABASE ID RELEASE 60%9438852 Negative regulators of RIG-I MDA5 signaling 50522 683206 299827 297989 498837 292892 100912032 246244 298696 681260 361373 64156 312937 311430 363984 GLUCURONIDATION%REACTOME DATABASE ID RELEASE 60%9437828 Glucuronidation 24861 154516 301595 574523 396527 113992 303953 289827 83472 396552 298280 396551 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME DATABASE ID RELEASE 60%9438463 G-protein beta:gamma signalling 24514 366508 24400 246144 24185 85243 24497 25326 652957 116630 140924 114103 116562 84477 81745 81504 25513 29322 24654 297173 25704 298947 171081 497931 497932 85385 84598 25746 MRNA EDITING%REACTOME DATABASE ID RELEASE 60%9437953 mRNA Editing 81635 25367 25383 170912 TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME DATABASE ID RELEASE 60%9438618 Tachykinin receptors bind tachykinins 25007 24808 24806 24807 29191 SIGNALING BY INSULIN RECEPTOR%REACTOME%R-RNO-74752.1 Signaling by Insulin receptor 291983 26954 171109 24514 246145 289924 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 58854 102552659 170668 29425 65179 24408 25167 64030 24954 64562 287871 24716 24506 24410 24505 24412 56718 117281 24446 301518 498576 29675 298514 29671 29670 29376 24968 24967 29372 690919 25704 112400 29666 24337 24329 117263 117262 116663 364814 290206 24592 103694903 246273 64022 161475 308869 60445 360814 24703 64226 83499 24245 24244 338457 170667 25267 309179 29614 29496 29211 295234 689852 64363 24497 652957 116630 140924 114103 24246 303353 24855 289257 84423 361992 84422 29668 81745 303605 29495 25614 292766 691318 25266 363131 362572 310091 360573 60427 24672 309168 365388 81827 24673 292887 288924 171081 24242 291245 94198 296072 29630 81511 296651 408248 297960 304893 24586 25746 301574 116590 297566 689779 117596 297797 291969 307821 296981 50689 297932 100912571 116455 116636 366545 289407 362802 94170 685232 85492 25233 300253 83613 290291 312754 83803 24185 29516 65248 300980 66023 25525 25326 360776 314612 305203 312664 25136 65052 432361 287716 114858 58960 501146 192126 29542 192213 83840 25467 192117 295357 364052 246150 315648 305614 117045 299147 78975 288589 25400 25150 100909655 117044 59323 25344 171140 84598 170577 117043 59325 25433 25435 25676 310533 64156 50522 25581 89807 29741 89804 85243 368044 83805 681260 64159 299159 100361543 498837 293650 100912032 116664 436582 83615 299971 362045 56011 79114 81504 170633 25513 83806 170700 313845 287670 54250 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 361388 25114 25022 29368 116499 25622 60662 85385 170582 24525 66017 60464 498416 29669 29757 29677 29672 287772 287984 311078 SIGNALING BY NODAL%REACTOME%R-RNO-1181150.1 Signaling by NODAL 25631 29357 294515 300054 293674 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 60%9437844 The citric acid (TCA) cycle and respiratory electron transport 293114 296190 100912599 81728 299310 690441 499529 85263 170587 295143 641434 315167 362749 94271 94173 24534 24533 363061 25682 288088 25027 361071 245958 295923 679739 301123 25488 245965 292845 500350 299739 678759 299008 56769 293453 26201 117098 24368 25179 29634 25309 310378 689271 293652 7066259 7066258 26203 7066257 26202 7066256 7066254 100363502 293655 54705 100909612 289218 289217 362474 314196 681418 301624 690848 81530 89813 362588 362897 100363268 293448 157074 80878 297990 100911417 299643 303922 301458 497902 7066248 301427 7066247 362344 311254 362495 114096 316632 307852 81829 65200 7066252 7066251 362810 29554 29478 291660 298942 684509 25708 360975 26197 116551 26196 293130 361385 54315 24860 26194 26199 289950 26192 26193 301011 362404 300677 298596 293991 361596 64539 140608 114630 300447 171082 299201 299954 300726 171374 171375 296086 300047 680288 366448 192241 294973 298748 300091 294964 296849 25246 363441 100911483 81654 294320 29754 25271 24439 79250 362837 362440 291103 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%R-RNO-1236975.1 Antigen processing-Cross presentation 291983 100365047 289924 289990 66021 58854 307821 29425 310710 24812 24811 83806 64202 25217 81803 103689996 287670 29675 29671 29670 24968 25581 24967 500904 29666 29184 117263 499985 117262 103690020 364814 290206 161475 85492 83499 29614 29669 502852 689852 303353 287716 29668 292766 295279 29677 29672 365388 81827 287772 79129 287984 311078 94198 29630 296651 408248 114553 HISTAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 60%9438659 Histamine receptors 170704 85268 24448 25461 MRNA EDITING: C TO U CONVERSION%REACTOME DATABASE ID RELEASE 60%9438005 mRNA Editing: C to U Conversion 25383 170912 REGULATION OF GAP JUNCTION ACTIVITY%REACTOME DATABASE ID RELEASE 60%9438401 Regulation of gap junction activity 24392 292994 83805 RHO GTPASES ACTIVATE PKNS%REACTOME%R-RNO-5625740.1 RHO GTPases activate PKNs 100360868 680097 313017 29753 295277 25576 83724 100912489 298795 117056 56011 364723 64373 56010 103693372 25594 25577 81745 291159 102548682 100360950 500569 500351 304813 297173 679983 29355 691496 102557184 207122 116670 114004 102551184 307511 CHROMOSOME MAINTENANCE%REACTOME%R-RNO-73886.1 Chromosome Maintenance 100362333 299112 116468 304573 288003 85242 301323 310511 246327 301965 25737 289758 316602 59102 689399 681382 100911204 307766 689296 83712 362548 89809 684439 294712 102551184 81513 298850 680097 690237 289150 361403 305270 295277 84490 100912489 364723 361416 361836 500054 315164 307861 297758 304528 307798 681185 102548682 25448 100360950 500351 290232 59294 679983 287524 361698 102557184 65137 296883 307805 311327 306464 288414 313048 100911727 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME DATABASE ID RELEASE 60%9438458 Downstream signaling events of B Cell Receptor (BCR) 291983 303024 114851 83571 366508 289924 24628 24629 25493 313874 289990 29434 314641 361696 58854 294048 102552659 64545 84482 29425 64156 64030 24954 50686 79240 24506 24505 56718 294235 117281 84027 24446 29675 294515 50522 29671 365367 29670 59265 29376 24968 25581 24967 690919 112400 29666 24337 24329 117263 310131 117262 364814 309361 290206 140607 81646 103694903 309165 246273 64022 161475 316241 296648 84351 64226 83499 305584 29741 25267 309179 29614 29496 85243 689852 83805 303353 24855 681260 361992 29668 81745 302415 292766 691318 25266 58918 60427 24672 365388 81827 24673 498837 100912032 365865 292887 94198 29630 296651 408248 81525 314856 309419 116590 307821 79114 81504 170633 25513 50689 89812 83806 170700 287670 54250 25443 25444 170579 293621 314850 25317 170583 29348 29349 84489 24605 361388 25114 25022 29368 116499 25622 100363500 361765 60662 25023 170582 85492 24525 66017 25156 60464 25233 312754 24185 29669 50557 432361 287716 362356 56822 29677 25408 25660 29672 29414 25467 287772 315648 287280 299147 287984 25150 311078 309295 59323 81736 59325 25433 SIGNALING BY ROBO RECEPTOR%REACTOME DATABASE ID RELEASE 60%9438514 Signaling by Robo receptor 304883 360891 360272 361517 58946 311860 100909840 58920 100909750 79115 81531 64303 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%R-RNO-199418.1 Negative regulation of the PI3K AKT network 309419 366508 116590 24628 24629 314641 294048 102552659 64545 24954 79114 64030 81504 170633 50689 25513 24506 89812 24505 294235 170700 117281 24446 54250 25443 25444 170579 365367 29376 314850 59265 25317 170583 29348 690919 29349 84489 112400 361388 24337 25114 24329 25022 29368 116499 25622 60662 140607 170582 103694903 246273 64022 66017 60464 25156 29741 25267 312754 309179 24185 29496 85243 50557 83805 432361 361992 691318 25266 56822 25408 25660 60427 24672 24673 25467 315648 365865 299147 25150 59323 59325 25433 ACTIVATION OF C3 AND C5%REACTOME%R-RNO-174577.1 Activation of C3 and C5 294257 406161 24232 24233 103689965 24231 362119 CARGO CONCENTRATION IN THE ER%REACTOME DATABASE ID RELEASE 60%9439227 Cargo concentration in the ER 84599 65134 361705 100912115 295461 685144 690252 310710 64154 58817 25423 171049 302470 301012 289994 65165 29183 58842 24827 287276 287275 246117 116666 25407 252929 310843 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%R-RNO-380972.1 Energy dependent regulation of mTOR by LKB1-AMPK 26954 290291 83803 362045 301574 65248 295234 360776 24855 303605 64562 287871 56718 310091 100361543 301518 501146 298514 295357 78975 100909655 117044 117043 297960 308869 60445 64226 SHC-MEDIATED CASCADE:FGFR3%REACTOME%R-RNO-5654704.1 SHC-mediated cascade:FGFR3 313845 54250 25444 293621 25317 170583 29349 84489 24605 29368 116499 60662 85385 81504 24525 66017 60464 B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 60%9439123 B-WICH complex positively regulates rRNA expression 100360868 317399 680097 295277 100912489 117056 364723 103693372 498109 65261 100361574 60571 368002 690966 291159 102548682 100360950 500351 303539 84486 307766 679983 81822 691496 102557184 363017 117526 690450 680493 306274 361420 83503 100912534 306817 313245 301246 83582 102551184 83581 362728 361784 G ALPHA (I) SIGNALLING EVENTS%REACTOME%R-RNO-418594.1 G alpha (i) signalling events 83633 29385 308163 171108 100124593 84007 246254 406163 246219 29238 50577 25111 25380 100363053 117027 192646 689936 408199 25370 29538 360750 60590 360579 54305 287730 690230 287673 25075 29234 502757 292413 301066 497196 29237 292419 690572 292409 171104 63843 24929 287910 554302 24247 89810 290493 24419 690472 60448 314649 54258 500317 60399 66025 306792 25432 78979 24318 78985 64803 113959 681706 60628 259222 78982 78983 259224 78980 64042 78981 288001 114492 78984 25601 84475 690158 24903 84348 29256 24772 171551 689869 24473 60665 24182 170704 690481 100363178 29190 25033 29471 24179 690334 81645 24664 54226 310444 100310881 25354 117029 100310886 24400 100310885 25555 25686 81664 81503 362454 25643 81657 294807 365901 363143 24677 29290 29141 81644 286924 100310879 100310878 100310875 100310877 100310876 690198 100911796 25516 24604 305236 171044 25689 297795 362505 171054 116744 362506 83518 498609 29733 24415 29415 497942 500089 246358 24613 24416 29363 81509 500347 363682 298006 24175 501177 81780 114105 287003 24232 25083 282832 767613 57302 266997 114211 57301 29335 301088 25323 85268 680188 58812 24797 246759 362119 360918 66024 245920 690448 679957 353250 29358 63887 100310880 25248 309212 25245 103690156 25340 24659 500101 TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME%R-RNO-1299287.1 Tandem pore domain halothane-inhibited K+ channel (THIK) 64120 PRC2 METHYLATES HISTONES AND DNA%REACTOME DATABASE ID RELEASE 60%9438540 PRC2 methylates histones and DNA 100360868 680097 295277 100912489 310511 117056 364723 103693372 360905 291159 102548682 100360950 500351 444984 679983 83712 444985 296653 681740 297705 691496 102557184 294287 84350 293104 312299 313048 102551184 STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME DATABASE ID RELEASE 60%9438413 Sterols are 12-hydroxylated by CYP8B1 81924 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 60%9438058 PLC-gamma1 signalling 24244 310738 25679 25262 25238 54223 25521 24225 81737 24680 25730 25050 25289 305509 25725 64532 64508 293508 59109 84420 25636 29699 24679 29691 81678 302950 24681 29241 25738 24242 100363500 170538 81646 29613 25054 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 60%9438221 Toll Like Receptor 4 (TLR4) Cascade 303024 116590 25493 689314 680127 363855 314322 292892 81771 308267 363520 64156 246116 291912 64350 498003 29469 296390 50689 25272 117281 314384 313121 287398 50522 500133 100912585 679539 315305 305549 114509 81647 301059 81649 362418 305451 305835 116663 100363500 309361 361765 289014 309684 81646 103694903 309165 315139 311245 84351 114495 364867 100910771 317546 60350 50658 361565 300980 300447 100912399 116596 116667 303200 315994 100912618 681260 501560 116554 24516 362356 81722 287707 24672 309452 24673 498837 315648 117269 116725 100912032 287280 25021 309295 81736 296321 362491 25742 60587 305751 309957 81525 304859 54226 HDR THROUGH HOMOLOGOUS RECOMBINATION (HR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME%R-RNO-5693567.1 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) 64557 497976 499870 100361529 116468 64012 303375 685055 288003 291787 498411 100909750 294800 310034 497672 497856 315969 25737 64156 311860 289758 59102 293452 498119 299638 689055 295052 297561 298884 50522 316235 297486 302953 102551085 171366 89809 293678 362288 362817 287634 293489 300711 114494 290805 64046 100362315 363924 499966 306734 301014 85482 308755 360254 361836 681260 304528 292673 59294 287524 498837 361698 100912032 296883 288414 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME DATABASE ID RELEASE 60%9438265 RIG-I MDA5 mediated induction of IFN-alpha beta pathways 24508 290749 690894 298205 683206 299827 25493 298211 298210 292892 24481 310461 246244 298696 681260 500491 64156 100911527 311430 312937 363984 54244 81722 287707 50522 297989 309452 498837 502965 100912356 502966 502962 100912032 301059 361373 309361 309295 309165 81736 84351 103690314 25742 305751 81525 54226 304859 100912314 TBC RABGAPS%REACTOME DATABASE ID RELEASE 60%9439288 TBC RABGAPs 297872 303734 79434 360956 100359937 288700 64670 302552 501854 25532 79121 24855 81830 360827 64862 29448 58974 117103 317580 366896 292886 360968 365372 287110 266688 313234 361697 84379 60445 311911 361227 499768 246294 RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME DATABASE ID RELEASE 60%9439266 Retrograde transport at the Trans-Golgi-Network 311919 287535 117051 84589 500249 364981 501069 309922 25218 286932 64187 60355 293344 100361513 296649 291309 316130 690961 313493 309306 60562 140673 310411 361407 361073 312689 364033 29528 303652 25151 293456 84379 291990 192152 100909548 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME%R-RNO-76046.1 RNA Polymerase III Transcription Initiation 691501 316810 498109 361102 100361574 690966 685465 294687 306542 690254 306012 246299 299347 362537 362858 685539 117526 310685 311487 300088 83503 100912534 361640 171068 366277 171063 301246 304204 362095 362088 361858 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 60%9438239 MyD88 dependent cascade initiated on endosome 303024 116590 25493 689314 317468 684440 363855 314322 81771 310461 308267 363520 64156 291912 498003 296390 50689 25272 117281 314384 313121 287398 50522 500133 100912585 679539 315305 305549 114509 81647 301059 81649 362418 305451 305835 116663 100363500 309361 361765 289014 81646 103694903 309165 315139 311245 84351 114495 338457 100910771 317546 50658 361565 300980 300447 100912399 116596 116667 303200 315994 100912618 681260 501560 116554 24516 362356 81722 287707 24672 300177 309452 24673 498837 315648 117269 116725 287280 100912032 309295 81736 362491 25742 60587 305751 309957 81525 304859 54226 HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME DATABASE ID RELEASE 60%9439214 HDR through MMEJ (alt-NHEJ) 64046 288079 84495 64012 291787 85482 84490 25591 303369 WAX BIOSYNTHESIS%REACTOME%R-RNO-8848584.1 Wax biosynthesis 293173 679520 302425 500368 FASL CD95L SIGNALING%REACTOME DATABASE ID RELEASE 60%9437869 FasL CD95L signaling 266610 25385 246097 64044 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 60%9437766 Assembly of the ORC complex at the origin of replication 362304 313138 301430 295596 291927 313479 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME DATABASE ID RELEASE 60%9439067 Nuclear Pore Complex (NPC) Disassembly 300259 299706 292085 117021 304862 58958 245922 113929 65274 360161 287830 116555 362281 25281 683983 54237 295692 25203 291874 81738 499974 113975 25497 362335 53372 294429 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 60%9438597 Sema4D induced cell migration and growth-cone collapse 297173 25537 78966 64373 24337 102552659 366957 362993 363875 308875 306790 81762 316009 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME%R-RNO-5693532.1 DNA Double-Strand Break Repair 116468 288003 301442 303369 308669 309595 290631 25737 361815 64156 65179 316794 500987 289758 59102 290997 362704 287927 295052 50522 307766 89809 114212 362817 300711 102551184 25591 114494 290805 64046 100362315 363924 499966 680097 306734 301014 85482 84490 295277 100912489 308755 364723 360254 361836 288079 681260 156826 304528 102548682 498749 25573 289757 259171 85245 100359600 100360950 311944 301128 361767 500351 29722 292673 290907 59294 313539 360748 313027 679983 287524 363251 498837 361698 116725 100912032 102557184 296883 84495 288414 25019 64557 497976 499870 100910954 100361529 64012 303375 685055 291787 498411 100909750 294800 310034 497672 497856 315969 311860 368002 293452 498119 309995 299638 689055 298884 297561 316235 297486 302953 306257 102551085 171366 362827 363247 293678 362288 287634 293489 116554 296099 289468 680537 REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME DATABASE ID RELEASE 60%9439079 Regulation of TP53 Activity through Methylation 305837 314856 304798 364382 100910954 50522 498837 362078 100912032 689820 311613 681260 289372 64156 114212 300711 361798 METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME DATABASE ID RELEASE 60%9439045 Metabolism of ingested SeMet, Sec, MeSec into H2Se 300691 24250 81676 25134 363285 25331 24962 29443 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME%R-RNO-400042.1 Adrenaline,noradrenaline inhibits insulin secretion 29716 24400 685451 25686 81664 60449 24239 81667 24175 64199 25289 116600 294962 25083 114120 306243 64532 83579 114118 114119 114117 25399 79218 300992 690825 100912034 680149 245986 50688 25297 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 60%9437960 Ubiquitin-dependent degradation of Cyclin D 291983 289924 29614 29669 689852 289990 303353 58854 681260 307821 287716 29425 29668 64156 94201 292766 83806 29677 287670 29675 29672 50522 365388 29671 81827 29670 24968 498837 25581 24967 287772 100912032 29666 287984 117263 311078 117262 364814 94198 290206 29630 296651 161475 408248 85492 58919 83499 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%R-RNO-110373.1 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 29240 362600 59294 116468 287524 288003 83507 361698 84490 89809 79116 296883 25737 304528 289758 288414 59102 25591 81513 100911727 COLLAGEN FORMATION%REACTOME DATABASE ID RELEASE 60%9438941 Collagen formation 289081 25506 84032 305104 306628 316313 25412 312115 114517 60379 29393 192362 300901 287899 64315 305078 678743 360526 24914 305253 294279 116552 353303 304021 288583 298101 29569 64204 85250 361612 102555086 313592 362285 83470 315071 365460 309837 294027 301012 363457 363158 84352 85251 25654 366474 85490 307582 290905 103689932 367236 64475 29345 685612 290637 100911730 499431 311716 362584 25724 64367 315714 314981 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%R-RNO-1655829.1 Regulation of cholesterol biosynthesis by SREBP (SREBF) 78968 301024 84509 302705 300095 24917 89842 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%R-RNO-997272.1 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits 29712 29713 170847 25743 690825 24400 117052 83633 116560 680149 60449 81667 81657 245986 114120 116649 50599 114118 114119 114117 29719 79218 VLDLR INTERNALISATION AND DEGRADATION%REACTOME DATABASE ID RELEASE 60%9439291 VLDLR internalisation and degradation 298296 81637 308578 65046 306825 116563 83800 58852 25696 58851 54241 140670 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 60%9437899 Eukaryotic Translation Initiation 64156 299872 100360057 367195 100360619 100911847 81729 681260 291615 498837 100912032 103692785 140655 362952 287417 360572 292964 367865 103690821 100912571 367265 100910180 294282 116636 29236 100360647 100911575 140662 100364265 100360841 103690015 684988 691531 295975 140661 64640 29283 56783 29284 103692831 28298 287436 100360679 26962 64302 302697 103693375 290641 689284 362041 192234 295660 300253 100360117 296709 103694404 117019 296302 317646 29288 81767 29282 81763 100360522 81768 81765 81769 64205 288599 311120 301299 100362830 292148 690468 314652 81775 293427 81770 29752 64638 81776 292762 299027 25348 300069 306079 103694169 293484 288516 65139 297756 64514 100912182 300079 171145 298700 117045 25347 682793 100910370 685963 124440 306926 691947 687780 29258 54318 100911110 100359922 161477 65043 25538 499782 100361079 303831 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME DATABASE ID RELEASE 60%9438435 NRIF signals cell death from the nucleus 310738 50522 24596 362548 498837 100912032 289231 681260 64156 113894 100911293 300802 691658 81751 365872 311245 292788 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 60%9438199 Telomere Maintenance 100362333 299112 116468 680097 304573 690237 288003 295277 84490 361403 85242 100912489 301323 364723 246327 361836 500054 301965 25737 307861 297758 304528 307798 102548682 289758 100360950 59102 500351 290232 59294 287524 679983 361698 102557184 89809 296883 288414 102551184 81513 100911727 HOMOLOGY DIRECTED REPAIR%REACTOME DATABASE ID RELEASE 60%9437975 Homology Directed Repair 64557 497976 499870 100361529 116468 64012 303375 685055 288003 291787 498411 100909750 294800 310034 497672 497856 315969 303369 25737 64156 311860 289758 59102 293452 498119 299638 689055 295052 297561 298884 50522 316235 297486 302953 102551085 171366 89809 293678 362288 287634 362817 293489 300711 25591 114494 290805 64046 100362315 363924 499966 306734 301014 85482 84490 308755 360254 361836 288079 681260 304528 292673 59294 287524 498837 361698 100912032 296883 84495 288414 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME%R-RNO-399721.1 Glutamate binding, activation of AMPA receptors and synaptic plasticity 24245 314856 81637 25252 65046 140724 140725 29629 29627 24246 60355 171026 24680 29628 140729 84347 29495 100911769 84591 315840 308578 24681 140670 84016 59317 25400 116563 25023 171140 METABOLISM OF STEROIDS%REACTOME%R-RNO-8957322.1 Metabolism of steroids 307092 25675 171516 24298 24294 79111 291211 365410 252898 353498 310645 362360 170588 500892 291182 362782 301024 298369 360348 24192 25284 117278 170698 361631 192242 24917 29580 302705 83724 89842 25429 81681 25329 84509 300095 65192 25428 58978 25427 78968 25557 313786 100910462 293688 308100 29500 117182 691018 116700 292097 24664 364764 25147 64677 303497 24230 114100 79243 79244 140910 83791 80899 286921 29632 296461 100911154 363675 81924 246211 24384 84608 80900 689872 50572 29637 365096 29189 289456 64191 311129 25322 24777 29725 502348 81727 298298 80848 287609 114700 313929 24950 83569 291283 25440 305291 81726 309262 25117 301264 619549 296972 29230 79122 116463 309527 25279 191574 25271 63865 60351 RHO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 60%9438442 Rho GTPase cycle 84014 303501 301709 307459 317576 299145 63994 288093 367085 315530 314903 362842 84031 306004 302819 303222 296060 307016 305367 498130 362456 500287 299012 293947 100363276 295971 308021 25183 29491 58834 295635 362378 360678 690130 308875 303351 29741 246217 140898 310460 361223 78966 84009 310635 361921 64373 303634 363509 307098 296603 304109 687105 114559 117020 293024 100362710 366957 292750 363460 310192 85384 301334 310999 362648 304193 290541 311647 309653 300115 312108 307178 295378 312113 679082 305341 500246 498282 311193 310074 291694 688429 308097 171296 500901 501456 296323 306279 310833 314618 306357 25486 287156 361617 313845 362590 363875 293660 25156 64465 85428 297173 100911545 306400 29662 24153 362893 315298 REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 60%9439096 Regulated Necrosis 266610 246775 25385 246097 117279 311786 60371 246756 78971 306886 690743 246240 64044 SYNTHESIS OF DNA%REACTOME%R-RNO-69239.1 Synthesis of DNA 291983 24708 100362333 114851 299112 83571 116468 289924 304573 288003 85242 289990 301323 246327 58854 307821 25737 362304 301430 29425 316273 64156 295596 289758 59102 83806 287670 29675 295052 50522 29671 29670 24968 24967 25581 29666 89809 117263 117262 364814 290206 85492 362817 161475 114494 81513 83499 29614 29669 689852 84490 361836 303353 681260 287716 29668 304528 292766 314642 29677 307639 29672 499914 59294 313138 296178 365388 29728 81827 287524 291927 498837 360621 312538 361698 287772 290842 313479 292071 29685 100912032 292058 291885 287984 288532 296883 311078 94198 29630 296651 288414 408248 100911727 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME%R-RNO-73776.1 RNA Polymerase II Promoter Escape 116550 171150 103695118 288533 289561 294693 81673 291773 682902 316123 294018 83828 293345 103690054 310784 171152 100360100 364834 306516 361365 303918 83830 498109 81674 100361574 84389 292778 690966 307485 170844 308415 288651 363633 502227 266713 117017 117526 83503 100912534 294236 361580 291703 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 60%9438029 Axon guidance 291983 171109 24514 289924 246145 246144 24628 24629 293847 313874 25453 289990 25597 314596 305104 29434 364686 306628 116562 58854 102552659 170668 29425 65179 24408 25167 64030 24716 24410 24412 361364 362513 117281 299331 24446 60630 292139 498576 25454 29675 29423 497815 29671 114523 29670 54319 29376 286908 83510 24968 65218 24967 299737 29372 498898 690919 361537 25704 112400 29666 502694 24337 24329 117263 117262 116663 364814 290206 24592 103694903 64022 161475 360814 24703 308875 83499 24245 24244 25267 313644 309179 29614 29496 29211 295234 689852 58920 64363 24497 652957 116630 140924 114103 24246 303353 289257 84423 362285 84422 29668 29495 25614 292766 691318 25266 362572 360573 60427 24672 309168 365388 81827 24673 290905 288924 171081 24242 291245 94198 296072 29630 81511 296651 362584 408248 304893 24586 25746 116590 360854 304883 361568 360891 307821 360272 58946 307641 312477 116549 29432 50689 301252 25615 58982 100910732 83785 25589 79208 316539 85492 29210 366492 363875 24884 116696 684969 298528 310643 83613 313494 312279 84358 312754 94268 171287 60589 100909840 300980 171574 66023 25525 25326 29302 314612 81531 685269 305203 312664 25136 432361 287716 79115 287876 65172 114858 58960 192126 29542 192213 25467 192117 364052 246150 315648 305614 299147 288589 25400 25150 309081 306400 59323 25344 54227 171140 84598 100361457 170577 59325 25433 25676 310533 288669 366508 65046 682507 314641 116690 29686 64156 245956 50687 306570 29491 50522 81822 100912585 25581 114509 64303 116563 83800 140694 85420 25751 81646 81732 25418 116671 290361 84357 89807 361597 246217 89804 25416 25417 84427 25415 65208 85243 78966 84009 64373 83805 24680 296603 681260 304109 114559 300955 25311 366957 64159 310192 83841 316009 308578 361517 25537 498837 140670 295378 296789 297518 306636 100912032 361882 25186 315711 24338 501203 363517 313498 287989 312652 29431 29433 310207 316369 311384 100911293 360546 300802 691658 81751 365872 54241 292788 140908 116743 81637 362045 100909750 301227 56011 84477 311860 79114 81504 81687 170633 25513 140941 83806 170700 313845 314384 287670 54250 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 289231 24605 81650 361388 25114 25738 25022 29368 116499 25622 100363500 60662 85385 170582 140593 24525 66017 60464 498416 246331 362398 29669 309280 64465 289820 81762 29677 29672 297173 81515 287772 81686 287984 311078 84393 266729 24718 310695 25696 289392 316639 362993 25744 29751 306790 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%R-RNO-174113.1 SCF-beta-TrCP mediated degradation of Emi1 291983 64515 289924 289990 292263 58854 307821 29425 64156 83806 287670 29675 50522 29671 29670 24968 25581 24967 29666 117263 117262 364814 290206 361765 161475 85492 83499 29614 29669 689852 303353 681260 287716 29668 292766 314642 362356 29677 29672 365388 81827 498837 287772 100912032 287280 287984 311078 94198 29630 296651 408248 S PHASE%REACTOME%R-RNO-69242.1 S Phase 291983 24708 362485 171150 114851 83571 289924 116468 25729 288003 289990 58854 25737 362304 29425 301430 84389 316273 64156 295596 289758 171102 499655 59102 294790 308937 304218 29675 314949 295052 50522 29671 29670 24968 24967 25581 691979 680014 29666 89809 117263 117262 364814 290206 63996 290577 161475 29486 362817 58919 305343 313304 81513 315958 114494 83499 29614 689852 84490 361836 303353 681260 29668 304528 292766 307639 59294 499914 313138 296178 365388 29728 81827 287524 291927 498837 360621 266713 312538 361698 290842 313479 100912032 29685 292058 291885 288532 296883 94198 29630 296651 288414 408248 100911727 100362333 299112 304573 85242 301323 246327 307821 94201 83806 287670 85492 29669 684771 287716 314642 362356 29677 29672 287772 292071 287280 287984 366275 311078 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 60%9437931 Activation of the phototransduction cascade 363143 24400 289878 85259 680149 688297 83686 307401 APOPTOSIS%REACTOME%R-RNO-109581.1 Apoptosis 29748 307562 64547 492821 25402 83502 246142 291755 313017 291752 29753 25576 64625 298795 56011 56010 64639 24224 25577 298534 171378 64044 83527 367786 316164 60371 259274 266704 502003 100360940 64026 171290 170538 171528 691670 85420 691695 100361468 116502 296654 691668 100361261 24917 288753 103690372 100911163 499156 29477 288064 305884 501266 29395 60374 116685 293852 317589 83584 298282 114214 25318 64204 498988 171116 24170 498072 114114 81818 361092 25309 140734 25311 116554 25614 64159 103689977 290537 100363502 78963 81762 58918 266610 246775 25385 246097 117279 311786 246756 306886 24205 24887 SIGNALING BY FGFR1%REACTOME%R-RNO-5654736.1 Signaling by FGFR1 116590 500985 306141 500526 64156 79114 81504 170633 25513 50689 170700 117281 313845 54250 25443 25444 50522 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 361388 25114 25738 25022 29368 116499 25622 60662 85385 103694903 170582 24525 66017 60464 499308 305539 299236 360903 83805 681260 24672 24673 498837 100912032 296072 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%R-RNO-193670.1 p75NTR negatively regulates cell cycle via SC1 310738 24596 297893 170820 84578 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 60%9438746 Metal ion SLC transporters 58976 306009 298786 291733 117240 25362 362861 316519 363985 25715 24268 305846 294281 289353 170840 294698 299903 314637 361986 171135 295455 300051 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 60%9438188 Synthesis of glycosylphosphatidylinositol (GPI) 100910143 288041 378774 305626 363464 29640 309051 192263 364032 366478 103694910 79112 315807 362756 287159 288238 MYOGENESIS%REACTOME%R-RNO-525793.1 Myogenesis 307505 50938 689314 100909750 64465 360715 29148 81649 337868 499497 361432 25714 311860 299766 60352 300811 360600 309957 83501 ETHANOL OXIDATION%REACTOME%R-RNO-71384.1 Ethanol oxidation 298079 29646 311569 100145871 296259 24172 171178 310903 29539 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME DATABASE ID RELEASE 60%9438272 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 100910771 683206 317546 689314 308267 29513 100912618 363520 24224 60352 291912 304987 296390 360557 64044 282817 312937 313121 301252 500133 679539 116725 287362 81649 29665 361373 117514 362418 309361 309295 116484 315139 362491 311245 84351 300732 290408 58923 114495 315435 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-RNO-69580.1 p53-Dependent G1 S DNA damage checkpoint 314856 291983 362485 304798 114851 100910954 83571 25729 289924 289990 58854 360860 307821 29425 64156 83806 287670 29675 295052 50522 29671 29670 24968 25581 24967 29666 117263 117262 364814 290206 114212 362817 161475 85492 300711 311575 114494 83499 29614 29669 689852 303353 681260 287716 29668 292766 29677 29672 365388 81827 685474 498837 287772 100912032 287984 311078 94198 29630 296651 408248 RHO GTPASES ACTIVATE FORMINS%REACTOME DATABASE ID RELEASE 60%9438505 RHO GTPases Activate Formins 304740 314212 499933 117281 81822 64303 103694903 303251 294429 299706 309179 292085 64373 83805 85252 287830 116555 691318 683983 81738 24672 24673 297176 171576 64515 680006 307483 361662 301701 298594 286993 308443 100911204 362548 500545 114592 362965 293733 681050 317252 64041 684439 294712 304951 304477 293660 684969 65201 298850 501706 312754 287598 363028 363174 100909840 362044 691493 289150 171529 305270 287624 83572 81531 64465 361416 24669 315164 295661 311191 315151 291441 681185 79115 287876 25448 316425 296137 297173 257649 83836 257644 315648 114764 299147 170845 29648 307805 498310 114514 84391 311327 306464 362186 360886 297522 100361457 303037 690538 501099 363059 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME%R-RNO-75067.1 Processing of Capped Intronless Pre-mRNA 116697 687711 314417 298075 680737 171365 683927 311166 299256 689116 298916 292683 304277 366952 291877 307524 681031 311670 309338 365407 100360682 361605 687679 501688 366468 292884 681062 REGULATION OF TP53 ACTIVITY%REACTOME%R-RNO-5633007.1 Regulation of TP53 Activity 364382 362675 116468 288003 689314 303241 362594 292064 64156 686781 64562 313777 361374 290744 305025 59102 56718 117281 305837 282844 301518 171355 295052 50522 140926 115771 362342 83712 282845 306571 290669 299694 297893 297822 365895 689820 362834 363292 310131 117526 103694903 360471 29517 114212 364298 362817 296648 58936 300711 311575 114494 64226 25405 290805 64046 116671 100362315 363924 117535 306734 301014 85482 361724 308755 361836 298696 311613 681260 289372 685619 304528 81745 84576 691318 362272 24672 287524 24673 314862 498837 314465 100912032 296883 288414 246334 140908 314856 64557 116550 304798 288533 100910954 100361529 291773 64012 682902 685055 305851 294018 291787 293345 498411 310784 294800 310034 171152 100360100 497672 81785 310511 497856 315969 307641 116549 307485 170844 89812 84577 114592 315713 81650 81649 114495 83803 24185 65248 311546 362078 54237 361798 685474 261730 315648 310614 679713 78975 498183 313048 SIGNALING BY MET%REACTOME DATABASE ID RELEASE 60%9439248 Signaling by MET 25473 500985 29645 364686 79121 64156 81504 25513 171337 117036 313845 24446 50522 293621 192362 117063 24697 303886 24605 25125 361388 305078 287942 25622 85385 292770 312574 311331 29135 360658 363875 24525 58947 361396 298941 303517 84357 25532 309816 83805 295347 681260 54245 25614 313388 100911248 63881 498837 307582 100912032 316758 360606 140433 311030 296121 116743 498798 ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME%R-RNO-199977.1 ER to Golgi Anterograde Transport 252902 246310 306570 24506 24505 287427 29211 289257 64159 301012 289994 310411 171121 300674 361407 361207 100910318 299075 361073 300888 309451 303652 293456 102555167 246117 291990 116666 362599 79120 25407 309144 100363782 81754 304978 309010 84599 65134 360709 361705 361577 100912115 60355 295461 500251 100910557 363858 680465 306264 56042 89868 690252 310710 64154 25423 171049 690961 362162 54350 64351 360611 29631 140673 361502 363136 100360302 315345 100909916 192243 93646 29183 503165 58842 94189 24827 297428 501550 292074 309678 290659 287276 362237 287275 56082 252929 100126191 310843 362504 29167 64462 81655 29564 290798 84428 116659 140734 308961 685144 299850 58817 302470 65165 114023 305614 297522 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME DATABASE ID RELEASE 60%9437879 Detoxification of Reactive Oxygen Species 297998 24787 58819 117254 25506 85431 66021 79462 25309 24248 94167 100910067 84485 25352 116686 298376 100363502 24786 79129 500904 24426 50551 116484 294744 114553 171562 64371 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME%R-RNO-77286.1 mitochondrial fatty acid beta-oxidation of saturated fatty acids 64304 113965 170670 171155 24158 100911186 140547 25287 25363 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME DATABASE ID RELEASE 60%9438075 PKA-mediated phosphorylation of CREB 29699 24244 24679 302950 54223 29241 25521 25289 24242 25725 305509 100363500 81646 64532 293508 64508 84420 25636 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 60%9438151 Polo-like kinase mediated events 287101 307511 308937 58921 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-RNO-5693579.1 Homologous DNA Pairing and Strand Exchange 290805 64557 64046 497976 100362315 499870 363924 100361529 499966 116468 64012 303375 306734 685055 301014 288003 291787 85482 498411 294800 310034 497672 497856 308755 315969 360254 361836 304528 59102 293452 689055 287524 102551085 296883 288414 300711 ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME DATABASE ID RELEASE 60%9438096 Activation and oligomerization of BAK protein 116502 64625 REGULATION OF GENE EXPRESSION IN ENDOCRINE-COMMITTED (NEUROG3+) PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 60%9438531 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells 83630 29458 60329 366214 RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 60%9439004 RHO GTPases Activate WASPs and WAVEs 288669 360620 58823 308666 116590 360854 682507 100909750 64465 313024 311860 300955 25614 81504 289820 287876 50689 317371 301009 679934 79249 81822 297518 303073 54227 81732 117542 315348 100361457 259242 363875 684969 117538 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 60%9438389 FGFR3b ligand binding and activation 29368 25444 25317 29349 84489 66017 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME%R-RNO-69563.1 p53-Dependent G1 DNA Damage Response 314856 291983 362485 304798 114851 100910954 83571 25729 289924 289990 58854 360860 307821 29425 64156 83806 287670 29675 295052 50522 29671 29670 24968 25581 24967 29666 117263 117262 364814 290206 114212 362817 161475 85492 300711 311575 114494 83499 29614 29669 689852 303353 681260 287716 29668 292766 29677 29672 365388 81827 685474 498837 287772 100912032 287984 311078 94198 29630 296651 408248 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME%R-RNO-76066.1 RNA Polymerase III Transcription Initiation From Type 2 Promoter 362858 685539 117526 316810 310685 361102 498109 311487 100361574 300088 83503 100912534 361640 690966 685465 294687 366277 171063 690254 301246 306012 362095 299347 361858 UBIQUINOL BIOSYNTHESIS%REACTOME%R-RNO-2142789.1 Ubiquinol biosynthesis 365592 29309 498332 DIGESTION AND ABSORPTION%REACTOME DATABASE ID RELEASE 60%9438416 Digestion and absorption 363465 25680 64055 25656 100359675 432367 367308 25711 25702 24197 COMPLEMENT CASCADE%REACTOME DATABASE ID RELEASE 60%9438231 Complement cascade 100911854 64668 24854 298288 445269 295703 84007 299928 64459 24236 24235 113959 24232 24233 24237 64023 313421 312705 155012 114091 365466 294257 366588 365367 498241 24231 289395 362119 303861 29251 298566 192262 81750 289057 299354 29687 113936 406161 29333 103689965 25621 29169 296545 54243 54249 25407 COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME%R-RNO-6811434.1 COPI-dependent Golgi-to-ER retrograde traffic 81754 304978 84599 361577 60355 500251 246310 310710 362162 360611 140673 315345 503165 297428 290659 100126191 362044 309159 171529 287624 314473 171304 315131 140932 304290 360953 690073 290627 65165 300674 114023 361207 84392 300888 314906 309451 84393 289168 296284 84391 362186 293502 102555167 85248 79120 315298 100363782 363059 315740 FATTY ACID SYNTHESIS%REACTOME DATABASE ID RELEASE 60%9437962 Fatty acid synthesis 24297 679520 307092 79242 171516 65030 24306 287424 313375 290623 681458 113976 313373 79244 679532 25290 56266 299732 289736 83792 170588 266604 100360507 24693 29743 59103 102556347 246074 58962 499018 498962 298423 117243 29411 83512 301120 312086 84024 29527 54398 363516 499358 289014 81639 29624 100911581 286904 296851 114097 171410 84013 25526 503122 680115 361802 24653 25527 291283 94340 25426 25288 287454 102549542 29328 114024 310848 64669 311865 24157 50671 24159 50549 367808 84575 309449 362809 359725 498728 29347 191576 191574 94199 266674 24296 24886 171400 50681 171402 CARNITINE SYNTHESIS%REACTOME DATABASE ID RELEASE 60%9437874 Carnitine synthesis 287379 170898 GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 60%9439268 Glycerophospholipid catabolism 360753 306460 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%R-RNO-2565942.1 Regulation of PLK1 Activity at G2 M Transition 303024 29753 304740 302661 114482 29214 308064 305467 683722 56010 252921 64156 117281 299331 25203 24679 304813 50522 361765 246294 680991 691918 361634 362504 680477 29167 305909 305882 29479 64462 293844 100911033 300963 363055 83572 81740 315423 367153 116659 85265 500069 291540 25594 681260 294010 306102 690209 311191 192228 299850 64158 316531 309692 296554 100362495 311529 305288 362356 311802 54237 311573 286919 360672 299730 58822 310344 83836 103690034 498837 261730 290626 305002 246150 114764 287280 311886 100912032 29213 117103 60347 116670 84593 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME DATABASE ID RELEASE 60%9438840 Endosomal Sorting Complex Required For Transport (ESCRT) 290635 308178 362118 365191 687208 297995 292925 100910929 288659 290775 292640 290851 681059 361916 681260 364419 64156 282834 679886 287873 50522 498837 363720 100912032 311030 362502 360834 287645 498798 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 60%9437782 Mitotic G1-G1 S phases 291983 24708 362485 171150 114851 24514 83571 289924 25729 289990 58854 360908 362304 301430 84389 29425 316273 64156 295596 171102 499655 59102 294790 117281 308937 29675 300947 295052 50522 29671 29670 24968 680111 24967 25581 297893 29666 117263 117262 103694903 100360427 161475 362817 58919 361178 116651 114494 83499 29614 689852 83805 303353 681260 29668 84576 292766 313138 24672 296178 365388 29728 81827 287524 24673 291927 498837 307126 360621 266713 312538 287961 313479 100912032 29685 291885 288532 296883 94198 29630 296651 408248 100362333 114483 299112 304573 399489 100909750 311562 85242 682033 301323 310511 291105 117104 246327 307821 311860 81758 684111 94201 83806 54238 25164 287670 85492 24185 29669 362763 25255 292787 305171 689523 287716 362356 29677 29672 81515 287772 315648 292071 287280 287984 366275 311078 313048 DNA REPLICATION%REACTOME%R-RNO-69306.1 DNA Replication 24708 291983 114851 83571 289924 116468 288003 289990 58854 360908 25737 362304 301430 29425 316273 64156 295596 289758 59102 29675 295052 50522 29671 29670 24968 24967 25581 29666 89809 117263 117262 364814 290206 161475 362817 114494 81513 83499 29614 689852 84490 361836 303353 681260 29668 304528 292766 307639 59294 499914 313138 296178 365388 29728 287524 81827 291927 307126 498837 360621 361698 312538 287961 313479 290842 100912032 29685 292058 291885 288532 296883 94198 29630 288414 296651 408248 100911727 100362333 299112 304573 399489 85242 311562 301323 291105 246327 307821 684111 83806 287670 85492 29669 287716 314642 29677 29672 287772 291137 292071 287984 311078 HISTIDINE, LYSINE, PHENYLALANINE, TYROSINE, PROLINE AND TRYPTOPHAN CATABOLISM%REACTOME%R-RNO-6788656.1 Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism 24813 29301 81676 66029 116682 291450 24616 299201 303272 680409 641315 641316 246307 29531 29700 300723 360719 89833 50719 309150 64192 364975 100360621 298942 360975 315439 103690164 100169747 681913 29416 311844 29383 299735 171385 59113 64206 100270683 24443 685999 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME%R-RNO-432722.1 Golgi Associated Vesicle Biogenesis 64678 317576 306332 313409 24803 140673 192243 83800 25751 64310 192152 25319 29292 100360087 367038 367304 360785 100362805 302671 29663 689955 287709 683687 89816 310746 302290 81659 291464 311404 295217 25387 288785 689256 360515 83730 641528 680476 309969 363476 362609 312694 296199 85491 25151 25306 361632 83576 81917 294900 54241 317630 364183 116743 289312 ADAPTIVE IMMUNE SYSTEM%REACTOME%R-RNO-1280218.1 Adaptive Immune System 304349 361714 289924 685844 252902 689757 315707 29645 684984 54266 25697 685048 308417 361696 309620 24934 294048 64545 306332 84482 25464 574531 171369 24954 50686 79240 24506 24505 307199 171293 313785 294235 689790 84027 501828 500331 292671 294515 301626 365367 59265 304382 25066 309304 499985 287818 140607 288568 308501 64310 171136 64357 316241 103690070 681236 25361 361618 499342 171055 313644 305584 100913063 499356 680910 100910725 362046 114709 360655 361873 361673 498287 295347 303353 24560 25713 306956 306957 501742 498079 685157 312711 89821 365388 683758 303298 312647 684480 365865 300649 94198 366518 474146 25621 287813 113937 314856 302934 116590 50689 500904 287276 25023 24884 362504 29167 367038 295338 24984 171574 81655 367304 29564 365542 100909630 290798 360785 84428 29144 50557 361704 116659 290644 287531 140734 294273 308961 294274 100909593 297596 299850 302671 29663 407756 25599 360777 100910669 315610 501779 501502 681341 29414 364049 501738 681182 63835 103689997 100910801 689817 499415 362445 362447 114553 689853 362443 296562 114851 83571 65046 308995 314641 25710 116689 292537 29448 294790 252857 25581 103690020 116563 83800 140694 25751 300678 309621 84357 25300 363577 315609 309622 294269 499537 302415 300955 100910488 688090 155918 24981 317371 294270 310727 308578 140670 54241 116743 309419 81637 690076 361710 652929 293618 301227 66021 301229 305081 690492 84349 25192 501869 680844 89812 83806 171337 287670 29184 309684 25679 25262 29669 362044 309159 171529 287624 64465 314473 171304 498022 24232 293508 56822 59326 25636 29677 25408 25660 29672 316333 287772 79129 287984 303666 84392 311144 314906 311078 84393 289168 296284 63865 310695 84391 362186 293502 81736 298702 85248 24223 315298 315740 291983 24628 24629 313874 289990 298317 29434 305268 58854 102552659 29425 64030 64202 56718 117281 24446 361289 29675 29671 29670 29376 24968 24967 690919 112400 29666 24337 24329 117263 310131 117262 364814 290206 103694903 246273 64022 161475 296648 24703 64226 83499 497811 25267 309179 29614 29496 29211 689852 24855 361992 29668 81745 292766 691318 25266 60427 24672 81827 24673 292887 29630 81511 296651 408248 100365047 307821 310710 24812 29432 24811 117553 25217 103689996 360640 288375 288378 363856 360647 81678 501797 100910732 85492 363875 25233 312754 24185 294010 432361 287716 25467 83477 315648 299147 25150 59323 314432 59325 25433 303024 366508 500985 25493 308267 64156 296390 81803 50522 309361 85420 81646 309165 84351 29741 85243 83805 681260 58918 300084 498837 116725 100912032 29431 29433 81525 361831 56011 295461 100910646 300968 362900 308968 100359528 288921 313722 79114 362376 81504 80897 170633 25513 140941 366854 170700 310363 303336 363083 313845 100360914 54250 300849 25443 313121 306825 25444 317241 170579 171043 293621 500587 311373 314850 679539 690769 25317 81815 170583 29348 93646 85273 29349 308283 84489 678726 24605 301674 361388 25114 364681 25738 306129 50558 25022 29368 311881 116499 313782 313101 25622 100363500 292757 60662 361765 85385 498089 287275 170582 303215 362367 287552 311245 140593 498941 25155 300724 24525 117524 66017 60464 25156 310843 100125363 309444 362002 291597 100910771 362081 361907 362277 502852 24932 363188 498959 362511 54259 64517 116596 301015 302987 312504 305424 301000 313806 100912618 494223 308999 60383 685144 360818 363790 304522 58817 361354 309453 316575 362356 308901 295279 192351 81515 287280 309295 297522 ACYL CHAIN REMODELING OF CL%REACTOME%R-RNO-1482798.1 Acyl chain remodeling of CL 360426 170670 24653 362702 171155 363521 REPRESSION OF WNT TARGET GENES%REACTOME%R-RNO-4641265.1 Repression of WNT target genes 25565 84424 362533 161452 299636 ERK MAPK TARGETS%REACTOME%R-RNO-198753.1 ERK MAPK targets 314384 24672 116590 100912585 24673 361565 300980 689314 114509 117269 315648 81771 81649 116663 501560 103694903 498003 50689 60587 309957 117281 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME%R-RNO-389887.1 Beta-oxidation of pristanoyl-CoA 83842 83522 170588 311849 296138 79244 25284 252898 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 60%9438584 Class C 3 (Metabotropic glutamate pheromone receptors) 100310881 100310886 100310885 500347 24419 690472 83633 78979 81657 246219 78985 287003 100363053 78982 78983 78980 78981 78984 100310879 60590 100310878 100310875 689869 502757 680188 100310877 170634 100310876 294394 29407 690572 690448 690481 100310880 24414 554302 690334 24415 24247 500089 500101 24416 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME DATABASE ID RELEASE 60%9438980 Trafficking and processing of endosomal TLR 338457 361689 63865 362862 29175 317468 64529 684440 364594 685174 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190375.1 FGFR2c ligand binding and activation 54250 25022 29368 116499 25444 60662 25317 170583 29349 66017 170700 60464 MRNA CAPPING%REACTOME DATABASE ID RELEASE 60%9437990 mRNA Capping 171150 289561 294693 316123 103690054 298075 364834 361365 81674 498109 100361574 291534 84389 313131 689116 292778 690966 308472 308415 288651 363633 502227 266713 117017 83503 100912534 294236 361580 291703 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 60%9437971 Triglyceride biosynthesis 681211 316737 363261 79223 84497 362732 252900 29653 313977 ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 60%9439152 Anchoring of the basal body to the plasma membrane 287612 307724 29753 304740 302661 304486 114482 29214 308064 305467 683722 56010 252921 292811 304007 313170 309486 311349 308923 303915 296136 266809 680407 313749 117515 293148 100912537 313067 117281 287836 299331 24679 308443 680991 691918 361634 362504 680477 29167 305909 305882 29479 64462 293844 100911033 300963 363055 83572 81740 315423 367153 116659 500069 291540 294010 690209 81830 311191 192228 299850 64158 316531 309692 296554 100362495 311529 305288 311802 54237 311573 286919 287383 360672 299730 361727 366872 58822 300880 310344 83836 100911746 103690034 290626 305002 246150 114764 311886 29213 117103 60347 84593 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 60%9439049 Establishment of Sister Chromatid Cohesion 304218 684771 314949 63996 290577 29486 305343 691979 313304 315958 680014 MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 60%9439308 MET activates PTK2 signaling 24446 25473 192362 307582 309816 316758 360606 305078 83805 140433 25614 298941 117036 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 60%9438016 Signaling by EGFR 291983 171109 24514 246145 289924 246144 24628 315707 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 361696 58854 294048 102552659 64545 170668 84482 29425 65179 24408 25167 64030 24954 50686 79240 24716 24506 24410 24505 24412 294235 56718 117281 84027 24446 498576 29675 294515 29671 365367 29670 59265 29376 24968 24967 29372 690919 25704 112400 29666 24337 24329 117263 310131 117262 116663 170538 364814 140607 290206 24592 103694903 246273 312574 64022 161475 296648 360814 24703 64226 83499 24245 24244 25267 309179 29614 29496 29211 295234 689852 64363 24497 652957 116630 140924 114103 24246 24855 303353 289257 84423 361992 84422 29668 81745 29495 25614 292766 691318 25266 362572 360573 60427 24672 309168 365388 81827 24673 365865 292887 288924 171081 24242 291245 94198 296072 29630 81511 296651 408248 304893 24586 25746 314856 116590 25050 307821 50689 81678 294981 360302 117255 85492 25233 83613 312754 24185 300980 362524 66023 25525 25326 314612 305203 312664 50557 25136 432361 287716 114858 58960 192126 29542 29414 192213 25467 192117 364052 246150 360820 315648 305614 299147 288589 25400 25150 59323 25344 171140 84598 170577 59325 25433 25676 310533 114851 83571 366508 25238 500985 306141 54223 314641 305509 64156 64508 84420 29699 24679 50522 24681 25581 29241 309361 81646 84357 89807 29741 89804 85243 83805 24680 681260 114559 302415 64159 58918 29691 498837 361120 100912032 311030 116743 498798 309419 362045 56011 79114 81504 170633 25513 89812 83806 170700 313845 287670 54250 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 361388 25114 25738 25022 29368 116499 25622 100363500 60662 85385 170582 24525 66017 25156 60464 25679 25262 29669 64465 25521 25289 25725 64532 293508 56822 25636 25408 29677 25660 29672 302950 287772 287984 311078 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME DATABASE ID RELEASE 60%9438297 TGF-beta receptor signaling activates SMADs 313477 59086 29357 50522 500985 498837 100912032 81810 361509 287155 681260 25631 311676 64156 83837 25490 25639 54281 29591 287607 297699 103690035 GAP JUNCTION TRAFFICKING%REACTOME%R-RNO-190828.1 Gap junction trafficking 315840 116563 83800 140694 25751 29584 394266 79128 266706 116561 24392 PINK PARKIN MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 60%9439117 Pink Parkin Mediated Mitophagy 300075 192647 50522 100911485 498837 681123 83529 299514 304017 685620 100912032 298575 361321 308416 64476 681260 64156 113894 266601 64862 362245 FRS-MEDIATED FGFR1 SIGNALING%REACTOME%R-RNO-5654693.1 FRS-mediated FGFR1 signaling 79114 81504 170633 170700 313845 54250 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 25114 25022 29368 116499 25622 60662 170582 24525 66017 60464 TRANSLESION SYNTHESIS BY POLK%REACTOME DATABASE ID RELEASE 60%9439185 Translesion synthesis by POLK 316344 313702 50522 116468 287524 309812 288003 498837 100912032 89809 296883 681260 25737 64156 304528 288414 59102 SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME%R-RNO-209931.1 Serotonin and melatonin biosynthesis 317675 24311 24848 246281 25120 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 60%9438162 A third proteolytic cleavage releases NICD 100911293 300802 691658 81751 365872 56761 406162 292788 289231 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME DATABASE ID RELEASE 60%9438323 APC C:Cdc20 mediated degradation of Securin 291983 290875 361389 64515 289924 296558 291689 366381 289990 311412 100360936 361831 304490 58854 307821 29425 64156 83806 287670 29675 50522 29671 29670 24968 25581 24967 29666 117263 117262 364814 290206 161475 85492 83499 29614 29669 689852 64193 303353 681260 287716 29668 292766 29677 29672 365388 81827 498837 296368 360643 498030 287772 100912032 305420 293155 287984 311078 94198 29630 296651 408248 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 60%9438235 Toll Like Receptor TLR1:TLR2 Cascade 303024 116590 25493 689314 363855 314322 81771 308267 363520 64156 291912 498003 296390 50689 25272 117281 314384 313121 287398 50522 500133 100912585 679539 315305 305549 114509 81647 301059 81649 362418 305451 305835 116663 100363500 309361 361765 289014 81646 103694903 309165 315139 311245 84351 114495 100910771 317546 50658 361565 300980 300447 100912399 116596 116667 303200 315994 100912618 681260 501560 116554 24516 362356 81722 287707 24672 309452 24673 498837 315648 117269 116725 100912032 287280 309295 81736 362491 25742 60587 305751 309957 81525 304859 54226 MRNA SPLICING%REACTOME DATABASE ID RELEASE 60%9437891 mRNA Splicing 289561 103690054 245976 298508 364834 361365 292778 690966 362394 246216 117017 83503 289693 81781 287113 192246 361859 361522 103689936 680891 302879 298075 310687 100360750 300361 287530 689890 313035 287739 363854 498109 290647 100361574 361849 170933 292683 366163 494445 117280 500695 307410 687575 366952 681410 295270 297695 295334 681031 302557 688288 100359574 363633 100911462 311670 298095 85434 684148 306222 360613 140931 679890 365407 100363406 296913 114765 362829 315903 362153 362264 362361 100912534 298385 687679 287765 287768 500684 79256 89819 298374 304859 116697 303607 687711 80846 288701 362990 316123 302670 287170 314417 308650 296320 361574 294232 680737 29678 293505 362152 295607 319110 171365 311166 81674 313449 299620 689116 361814 293671 64200 290614 685273 361995 29667 291877 307524 84486 60376 308335 366461 690303 117259 361887 366276 291794 292019 309338 294711 362223 498934 286973 295284 296126 100361269 100360682 291295 297455 361808 300996 362612 501926 361605 363082 313620 360803 361542 291060 362687 498425 290666 691538 292536 84401 309651 305479 102548514 683927 299256 245957 300092 317385 298916 304277 300208 297336 292007 117855 680309 292729 313583 689955 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%R-RNO-1660516.1 Synthesis of PIPs at the early endosome membrane 315422 309855 309008 307842 65052 310155 80849 114554 361632 287607 305419 116699 316457 363131 BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 60%9439279 Butyrophilin (BTN) family interactions 309620 497811 302934 288375 288378 306956 363856 306957 501797 684480 REGULATION OF TNFR1 SIGNALING%REACTOME DATABASE ID RELEASE 60%9439129 Regulation of TNFR1 signaling 683206 100362554 246244 83427 681260 103694380 60383 64156 687813 364386 64044 312937 50522 311786 246756 60371 498837 100912032 306886 94193 78971 311401 361373 308493 309295 309361 84351 100911911 362828 81859 SCAVENGING BY CLASS H RECEPTORS%REACTOME DATABASE ID RELEASE 60%9439035 Scavenging by Class H Receptors 24791 54225 282580 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 60%9438063 EGFR interacts with phospholipase C-gamma 24244 25679 25262 25238 54223 25521 24680 25050 25289 305509 25725 64532 293508 64508 84420 25636 29699 24679 29691 81678 302950 24681 29241 24329 25738 24242 170538 100363500 81646 MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 60%9439138 Mitochondrial translation termination 294696 364656 310653 289469 293754 290632 299743 311903 295238 293666 497876 296995 361037 309176 301240 297727 287962 300974 363023 297334 103691922 103693219 293149 363646 296551 683519 298517 297459 309140 287126 294963 367117 362517 290850 688912 363187 295224 309440 288621 288916 361883 113958 291206 289143 498406 64360 360594 301371 294672 297799 299938 362216 293054 680747 296134 689025 289491 303673 362094 171061 301250 299628 361473 361005 100361098 301552 287356 500199 301352 297372 294767 362388 691075 297601 303685 303746 287635 294230 292244 499185 292758 301249 100910528 56281 100363539 103692169 COLLAGEN CHAIN TRIMERIZATION%REACTOME%R-RNO-8948216.1 Collagen chain trimerization 353303 304021 298101 84032 305104 85250 313592 362285 25412 315071 294027 312115 301012 84352 85251 60379 29393 25654 85490 366474 103689932 367236 685612 499431 311716 362584 294279 314981 STEROID HORMONES%REACTOME DATABASE ID RELEASE 60%9438419 Steroid hormones 24298 24230 80848 24294 287609 114700 24950 79243 353498 25329 286921 29632 100911154 363675 305291 500892 291182 24384 25557 25117 360348 296972 313786 24192 79122 100910462 116463 29189 289456 25279 25322 63865 117182 361631 691018 116700 24664 64677 25147 TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME DATABASE ID RELEASE 60%9438040 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 316344 84478 313702 116468 309812 288003 100147704 301000 300795 289508 681260 25737 291526 140639 64156 304528 494338 292101 289758 298693 59102 59294 50522 316235 287524 498837 307905 361698 100912032 89809 296883 295704 288414 116643 PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME%R-RNO-433692.1 Proton-coupled monocarboxylate transport 29735 80878 25246 25027 65200 SODIUM CALCIUM EXCHANGERS%REACTOME%R-RNO-425561.1 Sodium Calcium exchangers 24244 84550 24242 311387 683667 140447 140448 498185 314396 29715 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME%R-RNO-110329.1 Cleavage of the damaged pyrimidine 315344 29541 114521 367090 81528 305957 680915 304577 LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME DATABASE ID RELEASE 60%9438741 Localization of the PINCH-ILK-PARVIN complex to focal adhesions 170922 REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 60%9439306 Regulation of Apoptosis 298282 171116 PHASE 3 - RAPID REPOLARISATION%REACTOME%R-RNO-5576890.1 Phase 3 - rapid repolarisation 171138 84020 25471 117018 246150 FRS-MEDIATED FGFR2 SIGNALING%REACTOME%R-RNO-5654700.1 FRS-mediated FGFR2 signaling 79114 81504 170633 170700 313845 54250 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 25114 25022 29368 116499 25622 60662 170582 24525 66017 60464 INITIAL TRIGGERING OF COMPLEMENT%REACTOME DATABASE ID RELEASE 60%9438230 Initial triggering of complement 114091 100911854 64668 294257 366588 24231 299928 298566 64459 192262 299354 29687 406161 24232 24233 103689965 64023 312705 54249 POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 60%9438879 Potassium Channels 64358 29712 65195 29713 170847 25468 25743 29682 117052 296395 24400 83633 54263 25472 84020 66022 116560 365241 276720 65206 29747 298908 60449 25470 81667 54262 81657 307900 66016 54261 116649 114245 50599 114244 65198 117018 310303 25469 117023 25327 24520 84429 114032 445371 171011 690825 83588 680149 65272 100909725 688996 499303 64120 307234 116489 245986 29553 116491 60326 58981 117101 29731 117105 29738 84390 171146 59324 25559 29737 170899 294961 294065 83731 170848 295360 27150 116745 29719 116695 114120 246153 114118 114119 114117 79218 25560 83535 PLATELET CALCIUM HOMEOSTASIS%REACTOME%R-RNO-418360.1 Platelet calcium homeostasis 81739 24244 114115 25679 25262 89823 140447 24215 140448 29659 113995 282822 29665 29598 60395 29599 24242 29693 683667 25391 29600 25505 25041 29715 PCP CE PATHWAY%REACTOME DATABASE ID RELEASE 60%9439099 PCP CE pathway 291983 81637 64558 65046 289924 289990 314212 58854 24881 307821 58868 29425 64156 83806 287670 29675 140584 50522 29671 100360552 29670 690516 24968 306782 24967 25581 24681 64512 116561 307799 29666 64303 315259 117263 117262 364814 116563 290206 83800 25023 161475 85492 363875 303251 83499 29614 29669 689852 303353 24680 681260 287716 29668 292766 29677 308578 29672 297173 365388 81827 498837 140670 287772 100912032 287984 311078 64566 25388 94198 29630 54241 296651 408248 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 60%9438810 Highly calcium permeable nicotinic acetylcholine receptors 170945 25102 25101 171131 25590 25103 81721 54239 79557 DAG AND IP3 SIGNALING%REACTOME%R-RNO-1489509.1 DAG and IP3 signaling 24244 25679 25262 25238 54223 25521 24680 25050 25289 305509 25725 64532 293508 64508 84420 25636 29699 24679 29691 81678 302950 24681 29241 25738 24242 170538 100363500 81646 ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME%R-RNO-6803544.1 Ion influx efflux at host-pathogen interface 84355 302422 24941 316519 PYRIMIDINE CATABOLISM%REACTOME%R-RNO-73621.1 Pyrimidine catabolism 58813 313574 65135 295620 287368 83784 100360582 315219 116593 289801 312373 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 60%9438489 Apoptotic cleavage of cellular proteins 499156 29477 305884 60374 307562 293852 116685 317589 25402 83502 83584 291755 25318 291752 64204 24170 81818 298534 25614 64159 103689977 64044 81762 83527 367786 60371 316164 64026 170538 85420 296654 24205 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME DATABASE ID RELEASE 60%9438317 Cdc20:Phospho-APC C mediated degradation of Cyclin A 291983 171576 290875 361389 64515 289924 296558 291689 366381 289990 311412 100360936 361831 304490 361662 58854 307821 29425 64156 83806 287670 29675 295052 50522 29671 29670 24968 25581 24967 29666 117263 117262 364814 290206 161475 85492 114494 83499 29614 29669 689852 303353 681260 287716 29668 292766 54237 29677 29672 365388 81827 498837 297176 296368 360643 287772 498030 100912032 305420 293155 287984 311078 94198 29630 296651 408248 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME DATABASE ID RELEASE 60%9438106 Integrin cell surface interactions 25304 83502 308995 54266 305104 306628 25464 29364 83727 100909977 64350 25353 315744 313785 114517 83577 360647 499271 364786 309684 25589 445442 310683 25361 24366 363265 25661 361969 24367 29302 311061 685269 362285 25713 116479 85251 25246 25118 366474 290905 24477 360606 25021 311144 499431 25406 362800 100911572 114489 315509 362584 29169 298702 81682 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-RNO-68867.1 Assembly of the pre-replicative complex 291983 289924 399489 311562 289990 291105 58854 307821 362304 29425 301430 64156 316273 684111 295596 83806 287670 29675 50522 29671 29670 24968 25581 24967 29666 117263 117262 364814 290206 161475 85492 83499 29614 29669 689852 303353 681260 287716 29668 292766 29677 29672 313138 296178 365388 29728 81827 291927 498837 360621 312538 287772 291137 313479 100912032 29685 292071 291885 288532 287984 311078 94198 29630 296651 408248 THE AIM2 INFLAMMASOME%REACTOME DATABASE ID RELEASE 60%9438821 The AIM2 inflammasome 304987 SMOOTH MUSCLE CONTRACTION%REACTOME%R-RNO-445355.1 Smooth Muscle Contraction 24244 313494 305679 102551071 296313 24584 25365 312492 29161 289759 500450 365377 685867 117557 25118 501831 360820 686098 25687 282843 24852 362816 24851 501203 24582 24242 288057 100909726 304447 100910474 685883 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME%R-RNO-111461.1 Cytochrome c-mediated apoptotic response 25309 64026 25402 100363502 78963 58918 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%R-RNO-2160916.1 Hyaluronan uptake and degradation 24782 294673 25406 293186 64468 24434 367166 282580 300757 64152 CA2+ PATHWAY%REACTOME%R-RNO-4086398.1 Ca2+ pathway 24244 64558 100910771 29748 25679 24400 25262 50664 365901 266715 24674 29322 497961 24654 313121 140584 289878 81678 161452 100361818 64512 688297 282581 307401 25400 64566 24242 SIGNALING BY SCF-KIT%REACTOME DATABASE ID RELEASE 60%9438459 Signaling by SCF-KIT 291983 171109 24514 246145 289924 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 361696 58854 294048 102552659 64545 170668 84482 29425 65179 24408 25167 64030 24954 50686 79240 24716 24506 24410 24505 24412 56718 294235 117281 84027 24446 498576 29675 294515 29671 365367 29670 59265 29376 24968 24967 29372 690919 25704 112400 29666 24337 24329 117263 310131 117262 116663 364814 140607 290206 24592 103694903 246273 64022 161475 296648 360814 24703 64226 83499 24245 24244 25267 309179 29614 29496 29211 295234 689852 64363 24497 652957 116630 140924 114103 24246 303353 24855 289257 84423 361992 84422 29668 81745 29495 25614 292766 691318 25266 362572 360573 60427 24672 309168 365388 81827 24673 25627 365865 292887 288924 171081 24242 291245 94198 296072 29630 81511 296651 408248 304893 24586 25746 314856 116590 307821 50689 85492 363875 24884 25233 83613 312754 24185 300980 66023 25525 25326 314612 305203 312664 50557 25136 432361 287716 114858 58960 192126 29542 29414 192213 25467 192117 301737 364052 363616 246150 116680 315648 305614 299147 288589 25400 25150 59323 25344 171140 84598 170577 59325 25433 25676 310533 114851 83571 366508 500985 314641 64156 116689 50522 25581 309361 81646 89807 361597 29741 89804 84427 85243 83805 24680 681260 302415 64159 58918 498837 100912032 309419 362045 56011 84477 79114 81504 81687 170633 25513 89812 83806 170700 313845 287670 54250 25443 25444 170579 316213 293621 314850 25317 170583 25124 29348 29349 84489 24605 361388 25125 25114 25022 29368 116499 25622 100363500 60662 85385 170582 84492 24525 66017 25156 60464 498416 29669 24918 367264 56822 25408 29677 25660 29672 81515 287772 287984 311078 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME DATABASE ID RELEASE 60%9438262 Fc epsilon receptor (FCERI) signaling 291983 171109 24514 246145 289924 246144 24628 317676 24629 293847 313874 25453 289990 25597 314596 29434 364686 361696 116562 58854 294048 102552659 64545 170668 84482 29425 65179 24408 25167 24954 64030 50686 79240 24716 24506 24410 24505 24412 294235 56718 117281 84027 24446 498576 29675 294515 29671 365367 29670 59265 29376 24968 24967 29372 690919 25704 112400 29666 24337 24329 117263 310131 117262 116663 364814 140607 290206 29337 24592 103694903 246273 64022 161475 296648 360814 24703 64226 83499 24245 24244 25267 309179 29614 29496 29211 295234 689852 64363 24497 652957 116630 140924 114103 24246 24855 303353 289257 84423 361992 84422 29668 81745 29495 25614 292766 691318 25266 362572 360573 60427 24672 309168 365388 81827 24673 365865 292887 288924 171081 24242 291245 94198 296072 29630 81511 296651 408248 304893 24586 25746 314856 116590 307821 29432 50689 24674 81678 311658 100361818 100910732 361400 85492 363875 25233 83613 312754 24185 300980 66023 25525 25326 314612 305203 50557 312664 25136 432361 287716 114858 58960 192126 29542 29414 192213 25467 192117 364052 83477 246150 315648 305614 299147 288589 25400 25150 59323 25344 171140 84598 170577 59325 25433 25676 310533 303024 114851 83571 366508 25493 363855 314322 314641 308267 64156 296390 25272 287398 50522 25581 309361 85420 81646 309165 84351 89807 29741 89804 363577 85243 83805 296603 681260 302415 64159 155918 58918 498837 295378 116725 100912032 29431 309419 29748 362045 361831 56011 84477 79114 81504 170633 25513 89812 83806 170700 313845 287670 54250 25443 313121 25444 170579 316213 293621 314850 679539 25317 170583 29348 29349 84489 24605 361388 25114 25738 25022 29368 116499 25622 100363500 60662 361765 85385 170582 84492 315139 311245 25155 24525 66017 60464 25156 100910771 317546 25679 25262 50658 29669 100912399 116667 100912618 116554 24516 56822 362356 25408 29677 25660 29672 81515 287772 287280 287984 311078 309295 81736 CILIUM ASSEMBLY%REACTOME DATABASE ID RELEASE 60%9439153 Cilium Assembly 287612 85258 64632 307724 363272 252881 303968 60627 24650 171455 116654 170714 314523 304740 302661 309126 300062 114482 313365 100362124 308064 305467 683722 252921 103690077 685284 499814 288585 503018 298767 361415 363286 287541 312651 373066 314393 300675 299209 363544 500571 500086 362265 117281 295106 299331 24679 309451 305287 25411 114089 83686 304037 79120 50556 84593 245709 100911734 29753 309156 304486 29214 56010 292811 304007 313170 309486 311349 308923 303915 296136 266809 680407 313749 117515 293148 100912537 313067 287836 308443 363760 171044 299246 362142 361930 315484 316102 300754 113948 680991 84581 691918 361634 362504 680477 29167 305909 305882 29479 64462 293844 100911033 300963 363055 83572 81740 315423 103689963 367153 116659 500069 291540 140734 294010 690209 81830 311191 192228 299850 64158 316531 309692 296554 100362495 311529 305288 311802 54237 311573 286919 360672 287383 361727 299730 58822 366872 300880 310344 100911746 83836 103690034 295654 290626 305002 246150 305918 361789 114764 305349 311886 29213 117103 60347 84392 289168 296284 85248 RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME DATABASE ID RELEASE 60%9438019 RAF-independent MAPK1 3 activation 58960 171109 24514 116590 293847 300980 364052 116663 25622 84598 25205 50689 24498 54237 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%R-RNO-201722.1 Formation of the beta-catenin:TCF transactivating complex 304832 171379 680097 295277 100912489 29417 364723 301965 300837 25520 84576 102548682 100360950 54244 100362634 500351 25565 84424 679983 362533 161452 304794 299636 297893 102557184 290829 295251 691857 300673 102551184 CELL-CELL COMMUNICATION%REACTOME%R-RNO-1500931.1 Cell-Cell communication 83502 682507 689314 308417 316313 29364 100909977 81504 25528 114517 293860 192362 361537 64315 81634 307799 25066 305078 81649 361432 25622 81918 363875 83501 361598 307505 29741 29211 85243 81679 64204 84006 140581 301112 83805 307237 171119 363509 314259 362279 29513 29647 499537 60352 315615 116554 300955 25614 64159 294027 116479 362332 29163 307618 362973 497229 170922 499443 100359836 361517 360687 680419 84407 288124 498515 307582 311163 50646 155183 362650 289992 29162 26955 29431 315546 192183 25150 316369 192248 100911730 310695 64563 117048 25409 360652 63836 25724 498281 29181 116777 360882 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%R-RNO-917977.1 Transferrin endocytosis and recycling 64678 170667 288562 297566 29199 689779 368044 117596 297797 291969 296981 29757 299159 288371 297932 116455 366545 289407 362802 293650 116664 24825 94170 685232 436582 83615 299971 PROSTANOID LIGAND RECEPTORS%REACTOME%R-RNO-391908.1 Prostanoid ligand receptors 24816 25637 292661 24929 63889 498475 309212 81752 25652 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 60%9437853 Glutamate Neurotransmitter Release Cycle 64832 362876 293645 64830 116470 287609 25550 116638 140592 140591 25531 84556 29642 366432 25558 24803 84012 25716 29483 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%R-RNO-5173214.1 O-glycosylation of TSR domain-containing proteins 304135 315879 445442 64456 102554393 309686 299314 310670 NOD1 2 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 60%9438271 NOD1 2 Signaling Pathway 100910771 317546 683206 689314 308267 29513 363520 100912618 291912 60352 296390 64044 312937 313121 500133 679539 116725 81649 362418 361373 309295 309361 315139 362491 311245 84351 114495 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 60%9438412 Synthesis of bile acids and bile salts via 24-hydroxycholesterol 307092 362782 171516 191574 291283 79111 301264 65192 192242 81924 25284 246211 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 60%9438567 Amino acid and oligopeptide SLC transporters 307811 29485 363103 155205 246239 246235 25550 292657 266767 287532 83612 84487 83509 500820 29484 170573 29483 170567 305540 50719 113918 50676 25648 298340 114518 315439 116726 114613 314441 170566 29464 310392 84012 309111 252919 117261 282712 29642 84551 170943 64554 664630 311168 116638 366432 192208 29323 681896 100911440 VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME%R-RNO-196843.1 Vitamin B2 (riboflavin) metabolism 85496 311536 751787 25732 362942 100911394 499328 GABA A RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 60%9438863 GABA A receptor activation 29708 140675 65187 29709 29707 24947 25451 29705 289606 25450 HEMOSTASIS%REACTOME DATABASE ID RELEASE 60%9438104 Hemostasis 89811 24508 56782 690894 246328 360950 361714 24854 361196 315707 360942 140447 295703 140448 686539 364206 309186 81804 114111 24481 360457 305679 100909700 116635 294643 308291 100909977 81821 100359512 100360977 50692 100911527 114517 50719 499271 100912356 116726 25027 81634 689064 499985 493810 170538 293118 25048 445442 310392 103690070 308875 100912314 29715 24617 85253 290749 298205 298211 25717 361873 298210 295347 64803 25310 84551 683667 24599 24598 84591 89823 502965 502966 502962 24189 81809 315509 314615 24400 116590 25686 81664 25643 282822 60395 29693 29600 50689 286924 293860 83785 25023 25391 25390 25081 89817 114095 84590 304983 307986 25673 406865 24653 305021 317191 25599 302470 25651 315610 300988 24786 81739 113947 140594 308899 89788 81662 114115 293886 296488 171115 497757 311795 29414 25206 497963 66012 100911881 81666 25202 309609 191569 25358 313611 100912012 29659 297073 25414 113995 363104 309242 500152 360918 293676 171016 307396 81750 363195 64312 500336 54404 309081 58935 309647 287774 60327 299909 498299 63836 103690314 116662 245955 312159 50693 25041 54225 308995 85471 29364 50687 116689 499099 299052 29699 24679 252857 299277 79113 24697 24681 140928 103694877 25441 298947 103690020 54249 24944 64373 303634 296603 366957 155918 81663 288001 29691 81743 24215 299276 24214 25387 25021 29665 29598 24825 29599 25388 25406 56611 25650 81749 84491 307811 25666 80878 103694857 301229 81683 500491 361076 83509 25524 65200 25528 171337 116498 114518 29251 25439 29636 29184 81649 309684 29186 25679 25262 362044 309159 171529 25518 287624 64465 314473 171304 25265 25619 25521 25725 293508 59326 25505 25636 297173 25246 100911545 360606 84392 311144 314906 84393 289168 296284 497931 84391 367745 497932 362186 293502 100134871 24153 85248 116510 315298 315740 691992 100911551 24514 116727 246144 502858 24946 24628 25259 292892 29434 116562 292661 312562 54248 24446 24791 25704 24703 24244 116673 58920 24497 652957 116630 140924 114103 81745 304917 25614 25266 24903 25216 24482 171081 24242 291245 81511 24483 24771 25746 497976 25373 100365047 94164 367039 300266 171120 499337 54254 293267 313438 361512 25172 499951 293692 64476 502359 294520 25159 691504 366960 64350 314930 306941 114124 360540 259237 246760 361619 26956 366998 54244 64516 25615 140656 368088 363875 246358 65051 307171 25233 25544 116669 313494 103689942 24366 103689938 362248 24185 64025 29516 25661 29681 361969 65037 289055 24796 25326 24367 83580 81613 29302 290757 685269 306761 363930 360746 316531 29476 245962 287009 288521 171577 29366 25404 300519 501872 64188 192249 103689972 100911485 298584 25150 63885 84598 50678 366508 304805 81803 59086 81778 25692 29409 100361138 60325 140866 85420 688705 296269 290361 89807 29741 100360868 89804 89805 84427 85243 24600 117056 83805 500709 24680 103693372 309207 304289 305795 499913 29254 25522 116479 24816 25523 295378 29436 25584 497978 170924 54226 79224 84477 81504 25513 313845 293621 24605 25622 85385 260320 25155 24525 25156 24175 25083 54245 291159 24936 81515 362558 691496 300339 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME%R-RNO-168181.1 Toll Like Receptor 7 8 (TLR7 8) Cascade 303024 116590 25493 689314 317468 684440 363855 314322 81771 310461 308267 363520 64156 291912 498003 296390 50689 25272 117281 314384 313121 287398 50522 500133 100912585 679539 315305 305549 114509 81647 301059 81649 362418 305451 305835 116663 100363500 309361 361765 289014 81646 103694903 309165 315139 311245 84351 114495 338457 100910771 317546 50658 361565 300980 300447 100912399 116596 116667 303200 315994 100912618 681260 501560 116554 24516 362356 81722 287707 24672 300177 309452 24673 498837 315648 117269 116725 287280 100912032 309295 81736 362491 25742 60587 305751 309957 81525 304859 54226 PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME%R-RNO-392851.1 Prostacyclin signalling through prostacyclin receptor 24400 292661 RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 60%9439237 rRNA processing in the nucleus and cytosol 64156 100360057 367195 100360619 100911847 81729 100359574 114021 290556 309628 688637 316317 317399 289740 310720 289810 314713 300050 100360664 314545 313744 313167 103689953 103692785 309301 293828 361977 287417 85432 360572 100912375 292964 363134 367865 362967 103690821 362703 291987 362902 299198 305258 287120 288647 303245 360574 367265 100910180 25135 360828 100911575 679140 140662 313581 300045 313243 100364265 313707 295050 100360841 363237 294975 303456 362229 298065 366017 305076 140661 314617 361159 64640 309458 316098 29283 297685 308441 690297 29284 317579 103692831 289724 28298 362214 686999 26962 361262 64302 296865 60373 103693375 290660 290641 312706 689284 365668 362041 314830 292747 100360117 296709 103694404 317646 81767 29282 81763 100360522 81768 81765 81769 64205 311120 301299 100362830 300092 690468 314652 81770 64638 306079 103694169 315697 310019 100912182 300079 25347 682793 100910370 685963 124440 306926 29258 100359922 65043 499782 100361079 CHYLOMICRON CLEARANCE%REACTOME DATABASE ID RELEASE 60%9438341 Chylomicron clearance 54225 24538 25728 300438 500564 OLFACTORY SIGNALING PATHWAY%REACTOME%R-RNO-381753.1 Olfactory Signaling Pathway 103693566 293262 366844 366843 366816 296037 366109 366103 293268 100912408 293091 293289 293255 500927 293083 293271 293278 294138 293281 293085 293285 293279 684170 293435 295834 287322 684171 365523 287324 362384 684179 287321 287329 287328 287325 366151 287310 287313 405239 100911893 287314 405233 287316 300414 500460 295827 300400 295822 295828 363710 103692138 295829 300408 366802 366112 366111 293402 293400 295801 100909438 315452 366100 100910500 292324 24400 363761 363762 363763 309222 293425 300640 366116 366115 366114 293424 295863 293429 294190 293817 295865 293815 293421 295869 294187 294186 293810 287309 300639 405242 405249 405248 293812 366123 405252 294198 295858 405258 364275 294197 405218 684376 300643 405219 363546 100912958 311180 405114 363549 405108 293399 405107 293398 311179 293392 293394 311173 311175 103693363 405106 405105 100910049 300395 103690375 100911586 405287 100911839 295891 295890 405281 300603 405293 287331 295870 366377 293375 296675 404984 293377 293373 293374 404986 405131 405132 303296 404978 404983 293379 296679 296678 405136 404977 56821 405137 405138 404976 296687 100910009 288006 405133 296689 405134 404999 404971 405115 404998 405112 680149 404975 293389 293382 404970 404969 404968 404967 680358 405126 405121 502755 404981 293370 405125 405124 405123 405122 363585 405150 687088 103690410 100911398 690821 100909831 406021 405166 289240 405203 405164 405160 289241 687097 100910928 405179 405177 405178 406018 289251 405175 404948 296682 24611 405146 405148 405144 406004 406003 404943 405140 100910719 405141 289261 293808 293809 404963 60451 293805 404962 404961 405158 404960 296694 405155 100909862 100912515 103693822 100910294 686677 294203 100909884 100909683 100909885 100910224 293336 293338 287613 287614 686660 293334 100911348 293340 100910999 293357 100912505 293327 404797 100909894 293329 405185 405181 405180 293321 405183 405182 289254 289255 405171 289250 405174 684683 100911380 293316 293319 406039 404794 100911376 100912217 100912327 363826 100910599 293761 100365887 293763 293764 293769 300524 300525 367065 367064 295910 684208 293192 100909578 293188 298396 100910467 293333 293759 100909534 295900 293140 103693685 295907 300560 301610 405362 100912374 405366 103690011 295786 405365 170816 100912540 315571 287000 405373 295772 295771 295766 103690286 295769 295767 295768 405344 405345 405346 405349 287247 287245 295781 405368 405352 295754 103690299 287240 287241 103690280 287237 295751 295750 299553 305841 295744 304985 405391 405390 303835 295712 295713 293773 295732 299570 300599 295747 293781 295743 293789 295741 293785 299576 295729 405966 100911988 299596 299586 287481 299588 287480 405383 405384 295721 405386 287484 287487 288816 288813 404826 100910837 404828 405948 102555599 404825 405955 405963 404820 100911043 364306 408031 404814 408030 404813 404816 404818 405969 100911035 405003 405970 405971 405325 405326 365302 287973 404858 405917 405049 405918 405927 405940 287970 288838 405928 405923 405934 404839 405935 286959 288187 287969 404832 302027 405952 404861 405920 405921 404860 405331 287262 405333 405050 100909966 405334 686967 405053 405051 405919 405329 405337 405911 288823 100911479 404859 100912097 405912 405915 404855 405914 103690304 404871 404875 290010 404876 405026 405303 405023 290018 286913 365330 288858 365327 365326 365323 289923 365324 100359873 405907 405904 405056 404862 404863 405057 100911670 404877 404878 404879 365334 365337 290009 405307 405312 290003 365336 290001 405033 290005 290006 404885 404887 290008 365340 404891 404894 405034 499860 404895 404898 404897 100909796 404888 288879 290020 100912605 288869 100910640 364979 288866 290050 304610 405065 405066 405064 684539 290049 405071 100910120 100909493 288887 288886 293223 287506 288198 100911944 293226 293224 293221 288192 288190 287509 363606 298044 293210 293211 287077 293218 298040 305711 298042 293215 293214 103693022 298038 298039 302954 405990 405993 287088 302045 287080 302958 287082 363639 287081 298046 287086 405991 287084 287083 298049 103693054 298045 100910876 405988 287513 100910162 405982 287516 287090 287517 687110 287093 405984 287514 405983 499237 405987 405986 405985 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME%R-RNO-77350.1 Beta oxidation of hexanoyl-CoA to butanoyl-CoA 64304 113965 170670 171155 100911186 140547 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS%REACTOME%R-RNO-425471.1 Bile salt and organic anion SLC transporters 289459 29735 64846 360539 80878 503568 25246 65202 25027 65200 58980 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 60%9437857 Branched-chain amino acid catabolism 63864 361215 81708 301384 298942 24513 29711 64203 29611 29592 25014 312381 287379 294972 25618 29603 170898 63938 361884 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME%R-RNO-444473.1 Formyl peptide receptors bind formyl peptides and many other ligands 292409 690158 681706 360579 690230 25380 362454 292413 690198 287910 292419 54226 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME DATABASE ID RELEASE 60%9438940 Assembly of collagen fibrils and other multimeric structures 304021 298101 84032 64204 305104 85250 306628 316313 313592 362285 25412 83470 365460 301012 363457 114517 84352 60379 29393 192362 25654 85490 64315 307582 290905 103689932 305078 678743 100911730 24914 362584 294279 25724 315714 RAF ACTIVATION%REACTOME DATABASE ID RELEASE 60%9439201 RAF activation 360573 58960 24514 312754 309179 24672 309168 293621 24673 64363 315648 24605 56011 299147 83805 25344 103694903 170577 691318 24525 24703 117281 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME DATABASE ID RELEASE 60%9439011 alpha-linolenic acid (ALA) metabolism 498728 679532 363516 170588 24157 83512 25288 84575 309449 171400 50681 79244 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME DATABASE ID RELEASE 60%9438330 Transport of nucleotide sugars 310808 311204 313139 296969 306866 501103 100158233 290959 298280 FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME%R-RNO-5658623.1 FGFRL1 modulation of FGFR1 signaling 25443 116499 170579 296072 305539 170633 360903 29349 INFLAMMASOMES%REACTOME DATABASE ID RELEASE 60%9438820 Inflammasomes 301252 287362 29665 117514 24224 116484 304987 300732 360557 290408 282817 58923 315435 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME DATABASE ID RELEASE 60%9438599 Degradation of the extracellular matrix 304802 408247 299606 83502 304608 25697 100911363 683849 294297 304135 25353 64529 81687 29154 171293 57025 25052 290257 192362 305078 315174 678743 29139 54281 25048 25393 85253 102554637 499285 29268 63849 25494 29543 83470 365460 24691 25481 292852 29153 171052 103690254 81707 117061 306404 85251 117033 103690164 25627 100911545 25246 25335 315388 307582 100169747 300339 81686 367236 66015 685612 499431 24291 25406 300341 29175 291848 24153 362347 54271 25403 65205 116510 29156 CALMODULIN INDUCED EVENTS%REACTOME DATABASE ID RELEASE 60%9438055 Calmodulin induced events 29699 24244 24679 29691 25238 302950 54223 24681 29241 25521 24680 25050 25289 24242 25725 170538 305509 100363500 64532 81646 64508 293508 84420 25636 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME%R-RNO-425397.1 Transport of vitamins, nucleosides, and related molecules 310808 100911721 313139 140915 64018 171144 306866 100158233 353307 298280 311204 170551 432363 80899 116642 302422 65039 94106 290959 58978 311839 140944 84608 60423 80900 296969 140860 501103 50572 94172 24546 259248 291582 680602 63997 170698 24221 288499 65194 84511 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 60%9437897 Ribosomal scanning and start codon recognition 140655 362952 100912571 294282 29236 100360647 103690015 684988 691531 295975 299872 56783 29284 100911847 287436 100360679 302697 295660 300253 296302 29288 288599 681260 100362830 292148 81775 293427 29752 81776 292762 299027 25348 300069 293484 288516 65139 297756 498837 298700 100912032 117045 691947 687780 29258 54318 100911110 161477 25538 303831 TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME DATABASE ID RELEASE 60%9438917 TWIK related potassium channel (TREK) 170899 65272 116489 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 60%9438641 PD-1 signaling 309621 499342 25300 315609 301626 315707 309622 24932 309304 25710 294269 103689997 25622 116689 688090 24981 300678 294270 G2 PHASE%REACTOME DATABASE ID RELEASE 60%9438372 G2 Phase 295052 399489 311562 362817 291105 114494 SIGNALING BY RETINOIC ACID%REACTOME DATABASE ID RELEASE 60%9438485 Signaling by Retinoic Acid 140868 307092 171516 83574 24172 117098 24706 24705 312495 299511 170635 100911902 311254 100365958 500629 291283 154985 266686 25756 25757 29554 362757 298942 25682 296849 25061 353252 116551 361504 308190 310903 116676 313689 297805 685750 289950 81654 191574 25271 685072 81530 89813 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-181430.1 Norepinephrine Neurotransmitter Release Cycle 29503 64832 362876 293645 64830 116470 287609 140592 140591 25531 84556 25558 24803 29253 25716 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%R-RNO-210745.1 Regulation of gene expression in beta cells 84482 24185 GLUCOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 60%9438423 Glucocorticoid biosynthesis 353498 24298 25117 24294 29632 360348 100911154 24664 500892 100910462 MULTIFUNCTIONAL ANION EXCHANGERS%REACTOME%R-RNO-427601.1 Multifunctional anion exchangers 64076 304784 114629 117267 301010 297910 29440 POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 60%9439124 Positive epigenetic regulation of rRNA expression 100360868 317399 680097 295277 100912489 117056 364723 103693372 498109 65261 100361574 60571 368002 690966 291159 102548682 100360950 500351 303539 84486 307766 679983 81822 691496 102557184 363017 117526 690450 680493 306274 361420 83503 100912534 306817 313245 301246 83582 102551184 83581 362728 361784 TRANSLESION SYNTHESIS BY POLH%REACTOME DATABASE ID RELEASE 60%9438042 Translesion Synthesis by POLH 84478 50522 116468 316235 287524 288003 498837 100912032 89809 296883 681260 289508 25737 64156 140639 304528 292101 288414 116643 59102 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 60%9437813 Stabilization of p53 314856 291983 304798 100910954 289924 289990 58854 360860 307821 29425 64156 83806 287670 29675 50522 29671 29670 24968 25581 24967 29666 117263 117262 364814 290206 114212 161475 85492 300711 311575 83499 29614 29669 689852 303353 681260 287716 29668 292766 29677 29672 365388 81827 498837 287772 100912032 287984 311078 94198 29630 296651 408248 SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 60%9438364 Signaling by FGFR4 116590 500985 306141 500526 83805 681260 64156 79114 81504 170633 50689 25513 170700 117281 313845 54250 25443 25444 24672 50522 170579 316213 293621 24673 314850 25317 498837 170583 29348 29349 84489 100912032 24605 361388 25114 25738 25022 29368 116499 25622 60662 85385 170582 103694903 24525 66017 60464 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 60%9438146 APC C-mediated degradation of cell cycle proteins 291983 171576 290875 361389 114851 64515 83571 289924 296558 291689 366381 114482 289990 311412 100360936 292263 361831 310806 304490 361662 58854 307821 29425 64156 83806 294790 25203 287670 29675 295052 50522 29671 29670 24968 114592 24967 25581 29666 117263 117262 364814 361765 290206 362817 161475 85492 114494 83499 29614 29669 689852 64193 303353 681260 287716 690209 29668 292766 314642 362356 54237 29677 29672 365388 81827 498837 297176 261730 296368 360643 287772 498030 287280 100912032 305420 287984 293155 311078 94198 29630 296651 408248 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 60%9438720 SIRT1 negatively regulates rRNA Expression 500351 100360868 680097 679983 295277 100912489 691496 117056 364723 102557184 103693372 291159 102548682 308911 102551184 302553 100360950 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 60%9438220 mTORC1-mediated signalling 100912571 300253 26954 116636 362045 298514 83840 295234 295357 360776 56011 117045 292887 100909655 117044 287871 117043 297960 308869 25435 64226 56718 310091 100361543 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 60%9438382 FGFR1 ligand binding and activation 54250 25443 25444 170579 25317 170583 29349 29368 116499 60662 79114 170633 66017 170700 THE PROTON BUFFERING MODEL%REACTOME DATABASE ID RELEASE 60%9438287 The proton buffering model 85263 25708 100909612 24860 54315 PROLINE CATABOLISM%REACTOME DATABASE ID RELEASE 60%9437855 Proline catabolism 680409 641315 641316 100270683 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%R-RNO-201681.1 TCF dependent signaling in response to WNT 291983 304832 289924 289990 58854 24881 300837 58868 29425 64156 29675 50522 29671 29670 161452 24968 25581 24967 64512 297893 29666 117263 117262 364814 290206 161475 102551184 83499 303251 680097 29614 689852 295277 100912489 364723 303353 309512 681260 85252 25520 29668 84576 102548682 292766 290794 100360950 100362634 500351 300084 365388 81827 679983 304794 498837 100912032 102557184 94198 29630 296651 408248 309419 64558 301965 307821 307641 116549 83806 54244 291209 287670 83721 80722 500666 503000 499593 25221 293990 246768 81650 65027 312936 308692 293649 361765 100912050 290317 287102 293897 289026 85492 679110 291678 140586 293165 303811 25233 171379 24185 29669 29417 287716 25404 29677 58822 29672 25565 84424 362533 299636 287772 287984 500863 311078 303181 286994 290829 295251 691857 300673 299802 499918 24205 303412 498233 296121 313589 312781 498997 OTHER INTERLEUKIN SIGNALING%REACTOME%R-RNO-449836.1 Other interleukin signaling 116558 296541 25466 116470 25402 24932 311783 25556 140924 25610 171106 81803 24500 361749 81802 310132 304091 688622 682457 301365 116996 25670 362076 362077 685840 298518 362628 307403 29197 25746 RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME DATABASE ID RELEASE 60%9439224 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 290805 64557 293452 497976 64046 499870 689055 64012 499966 306734 303375 85482 291787 497672 497856 102551085 308755 360254 361836 362288 300711 FATTY ACID CATABOLISM%REACTOME%R-RNO-8978919.1 Fatty acid catabolism 113965 170670 311849 24158 79244 291939 252898 24624 83842 83522 170588 293829 64562 85239 25756 100363074 25757 29740 65183 679565 25682 117543 688517 100911186 84029 25284 64304 363516 299193 25045 302640 26759 315173 100910957 85255 300083 293453 361993 619561 296138 361992 304500 114209 291076 65192 361413 307170 25287 291075 315973 25413 29726 289125 171155 192272 681337 24157 170465 308518 78975 291135 25271 171142 503049 25357 117035 140547 404280 50681 25363 29510 ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME%R-RNO-5624958.1 ARL13B-mediated ciliary trafficking of INPP5E 363272 114089 304037 ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME%R-RNO-379398.1 Enzymatic degradation of Dopamine by monoamine oxidase 24267 29253 DAP12 INTERACTIONS%REACTOME%R-RNO-2172127.1 DAP12 interactions 291983 171109 24514 246145 289924 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 361696 58854 24934 294048 102552659 64545 170668 84482 29425 65179 24408 25167 64030 24954 50686 79240 24716 24506 24410 24505 24412 294235 56718 117281 84027 24446 498888 498576 29675 294515 29671 365367 29670 59265 29376 24968 24967 29372 361537 690919 25704 112400 29666 24337 24329 117263 310131 117262 116663 170538 364814 140607 290206 24592 103694903 246273 64022 161475 296648 360814 24703 64226 500338 83499 24245 24244 25267 309179 29614 29496 29211 295234 689852 64363 24497 652957 116630 140924 114103 24246 24855 303353 289257 679787 84423 361992 84422 29668 81745 29495 25614 292766 691318 25266 362572 360573 60427 24672 309168 365388 81827 24673 365865 292887 288924 171081 24242 291245 94198 296072 29684 29630 81511 296651 408248 304893 24586 25746 314856 116590 25050 307821 50689 81678 85492 363875 25233 83613 312754 24185 300980 66023 25525 25326 314612 305203 312664 50557 25136 432361 287716 114858 58960 192126 29542 29414 192213 25467 192117 364052 501738 246150 315648 305614 299147 288589 25400 25150 59323 25344 171140 84598 170577 59325 25433 25676 310533 114851 83571 366508 25238 54223 314641 305509 64156 64508 84420 29699 24679 50522 24681 25581 29241 309361 81646 89807 29741 89804 85243 83805 24680 296603 681260 302415 64159 155918 58918 29691 498837 295378 100912032 309419 690076 362045 25110 301227 56011 301229 79114 81504 170633 25513 25528 89812 83806 170700 313845 287670 54250 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 361388 25114 25738 25022 29368 116499 25622 100363500 60662 85385 170582 25155 24525 66017 25156 60464 25679 25262 29669 25521 25289 25725 64532 293508 56822 25636 25408 29677 25660 29672 302950 287772 287984 311078 24223 ORGANIC ANION TRANSPORT%REACTOME%R-RNO-561048.1 Organic anion transport 29509 89776 365398 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME DATABASE ID RELEASE 60%9438554 Synthesis of 5-eicosatetraenoic acids 25290 296851 114097 29624 312086 84024 MET PROMOTES CELL MOTILITY%REACTOME%R-RNO-8875878.1 MET promotes cell motility 24446 63881 25473 192362 307582 316758 309816 361388 360606 295347 83805 305078 287942 54245 140433 81504 25614 363875 313388 298941 117036 303517 100911248 171337 MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME%R-RNO-163316.1 Mitochondrial transcription termination 85261 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME DATABASE ID RELEASE 60%9438752 CREB phosphorylation through the activation of Adenylate Cyclase 100363500 305509 81646 293508 64508 29241 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME%R-RNO-69166.1 Removal of the Flap Intermediate 296883 59294 25737 287524 289758 85242 361698 84490 301323 246327 59102 361836 SIGNALING BY NOTCH2%REACTOME DATABASE ID RELEASE 60%9438998 Signaling by NOTCH2 81517 117258 29492 297767 679028 311332 303101 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%R-RNO-1855183.1 Synthesis of IP2, IP, and Ins in the cytosol 365382 317576 80849 282636 83523 362590 171088 116699 290651 316376 85238 GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME%R-RNO-389661.1 Glyoxylate metabolism and glycine degradation 305348 293453 29711 117098 680021 29611 365314 299201 641315 641316 311254 25134 309312 100911564 24792 171133 306586 361272 29554 298942 25721 360975 293949 83784 289950 81654 100270683 685325 311446 316342 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME%R-RNO-163125.1 Post-translational modification: synthesis of GPI-anchored proteins 362133 114589 294241 25586 54279 362934 117522 311169 313488 103694910 100910410 116658 79112 113910 50692 353251 300017 300025 288038 296360 502017 288041 316400 691120 296394 541462 363464 691259 81506 353304 60378 29640 680210 192263 295543 303277 207113 300046 24197 103691942 312806 287159 288238 502308 311836 305235 100910143 305626 303311 291132 415062 116597 364032 314855 498992 60333 315807 367308 362756 681194 499260 300027 304966 378774 171459 360838 363104 309051 29142 315075 24832 300653 295382 292124 690037 366478 363060 100359675 MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME%R-RNO-5389840.1 Mitochondrial translation elongation 114017 294696 364656 310653 289469 293754 290632 299743 295238 293666 497876 296995 361037 309176 301240 297727 287962 300974 363023 297334 103691922 103693219 293149 363646 296551 683519 298517 297459 309140 287126 294963 367117 362517 290850 688912 363187 295224 309440 288621 288916 361883 113958 291206 289143 498406 64360 360594 301371 297799 299938 362216 293054 680747 296134 689025 289491 303673 362094 171061 301250 299628 361005 100361098 301552 287356 500199 301352 297372 294767 362388 691075 297601 303685 303746 287635 294230 292244 499185 292758 301249 100910528 56281 100363539 103692169 FORMATION OF THE EDITOSOME%REACTOME%R-RNO-75094.1 Formation of the Editosome 25383 170912 ABACAVIR TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 60%9439018 Abacavir transport and metabolism 29503 29504 24172 362282 311352 100363253 310903 24904 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%R-RNO-204174.1 Regulation of pyruvate dehydrogenase (PDH) complex 54705 29554 298942 296849 25682 117098 116551 289950 81654 25271 311254 81530 307852 89813 ACTIVATION OF RAS IN B CELLS%REACTOME DATABASE ID RELEASE 60%9438882 Activation of RAS in B cells 293621 313874 24525 24605 29434 DAP12 SIGNALING%REACTOME DATABASE ID RELEASE 60%9438064 DAP12 signaling 291983 171109 24514 246145 289924 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 361696 58854 24934 294048 102552659 64545 170668 84482 29425 65179 24408 25167 64030 24954 50686 79240 24716 24506 24410 24505 24412 294235 56718 117281 84027 24446 498576 29675 294515 29671 365367 29670 59265 29376 24968 24967 29372 361537 690919 25704 112400 29666 24337 24329 117263 310131 117262 116663 170538 364814 140607 290206 24592 103694903 246273 64022 161475 296648 360814 24703 64226 500338 83499 24245 24244 25267 309179 29614 29496 29211 295234 689852 64363 24497 652957 116630 140924 114103 24246 24855 303353 289257 84423 361992 84422 29668 81745 29495 25614 292766 691318 25266 362572 360573 60427 24672 309168 365388 81827 24673 365865 292887 288924 171081 24242 291245 94198 296072 29684 29630 81511 296651 408248 304893 24586 25746 314856 116590 25050 307821 50689 81678 85492 363875 25233 83613 312754 24185 300980 66023 25525 25326 314612 305203 312664 50557 25136 432361 287716 114858 58960 192126 29542 29414 192213 25467 192117 364052 246150 315648 305614 299147 288589 25400 25150 59323 25344 171140 84598 170577 59325 25433 25676 310533 114851 83571 366508 25238 54223 314641 305509 64156 64508 84420 29699 24679 50522 24681 25581 29241 309361 81646 89807 29741 89804 85243 83805 24680 296603 681260 302415 64159 155918 58918 29691 498837 295378 100912032 309419 362045 25110 301227 56011 79114 81504 170633 25513 89812 83806 170700 313845 287670 54250 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 361388 25114 25738 25022 29368 116499 25622 100363500 60662 85385 170582 25155 24525 66017 25156 60464 25679 25262 29669 25521 25289 25725 64532 293508 56822 25636 25408 29677 25660 29672 302950 287772 287984 311078 24223 M PHASE%REACTOME DATABASE ID RELEASE 60%9438150 M Phase 291983 289924 289990 58854 29425 117281 29675 29671 29670 24968 24967 29666 117263 117262 364814 290206 103694903 161475 83499 309179 29614 689852 303353 360161 29668 292766 691318 24672 365388 81827 24673 297176 296368 360643 498030 305420 293155 94198 29630 296651 408248 81754 299557 306594 307169 317425 300149 116590 361308 103690018 362798 60336 113961 287447 60334 291914 100360828 498266 307821 307641 116549 50689 301701 298594 286993 308443 100911204 362548 681050 317252 25023 684439 85492 294712 304951 304477 56082 298850 501706 312754 287598 363028 363174 691493 289150 305270 83572 361416 24669 315164 295661 287716 311191 291441 681185 25448 316425 313977 296137 257649 83836 257644 315648 114764 299147 29648 498310 114514 311327 306464 303037 24708 304740 292263 64156 499933 25203 304218 314949 50522 25581 689820 63996 290577 29486 305343 102551184 53372 313304 315958 290668 294429 300259 299706 680097 292085 117021 304862 295277 100912489 364723 58958 245922 113929 24680 65274 681260 85252 287830 102548682 116555 362281 25281 100360950 683983 295692 500351 291874 81738 499974 679983 113975 498837 102557184 100912032 25497 362335 171576 290875 361389 64515 680006 296558 291689 366381 311412 100360936 117104 361831 304490 361662 65158 83806 287670 500545 114592 362965 293733 81650 64041 65201 25437 114087 60374 362779 29669 362044 171529 315330 64193 287624 64465 684771 295107 362519 54237 305392 363481 29677 29672 287772 287984 170845 307805 311078 84391 362186 360886 297522 315740 363059 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 60%9438621 Centrosome maturation 362980 692032 29753 304740 302661 114482 29214 308064 305467 683722 56010 252921 362203 287929 306599 308663 308870 117281 299331 309098 25203 24679 680991 691918 361634 362504 680477 29167 305909 305882 29479 64462 293844 100911033 300963 363055 83572 81740 315423 367153 116659 500069 291540 294010 690209 311191 192228 64158 299850 316531 309692 296554 100362495 311529 305288 311802 311573 54237 286919 360672 299730 58822 310344 83836 103690034 290626 305002 246150 114764 311886 29213 60347 84593 MITOTIC G2-G2 M PHASES%REACTOME%R-RNO-453274.1 Mitotic G2-G2 M phases 291983 303024 171150 114851 289924 304740 302661 289990 114482 308064 305467 683722 252921 58854 29425 84389 64156 287101 171102 117281 308937 299331 25203 24679 29675 295052 50522 29671 29670 24968 25581 24967 29666 117263 117262 364814 290206 103694903 362817 161475 114494 83499 29614 689852 303353 681260 85252 29668 292766 24672 300084 365388 81827 24673 498837 266713 100912032 94198 29630 296651 408248 84593 362980 692032 100910954 399489 29753 311562 682033 29214 291105 117104 56010 307821 100359528 171103 361643 361613 29380 406168 362203 287929 306599 308663 83806 308870 309098 287670 304813 301252 678726 361765 85492 246294 680991 691918 361634 362504 29167 680477 305909 305882 361907 29479 64462 29669 293844 100911033 300963 363055 311546 83572 81740 315423 367153 116659 85265 500069 291540 25594 294010 690209 287716 306102 311191 192228 299850 64158 316531 309692 296554 100362495 311529 362356 305288 311802 54237 311573 286919 58921 29677 360672 299730 58822 29672 310344 300126 83836 103690034 261730 290626 305002 287772 246150 315648 114764 311886 287280 29213 287984 117103 60347 116670 311078 307511 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME%R-RNO-418359.1 Reduction of cytosolic Ca++ levels 29598 24244 29599 24242 29693 683667 24215 140447 25391 29600 140448 29715 SIGNALING BY BMP%REACTOME%R-RNO-201451.1 Signaling by BMP 103691556 367100 25378 29530 25495 290921 690516 686129 499508 140590 79210 361831 59328 363455 25237 289264 81507 500485 81920 641452 29373 29263 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME DATABASE ID RELEASE 60%9438077 PKA activation in glucagon signalling 29699 24679 302950 54223 29241 25521 25289 305509 25725 64532 293508 64508 84420 25636 HS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 60%9438817 HS-GAG biosynthesis 84406 116673 114002 363618 25615 103690051 58920 25216 691984 25592 311215 294449 29633 684979 171517 292155 299907 293451 302489 317322 290959 303218 316325 24771 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 60%9438827 Advanced glycosylation endproduct receptor signaling 81722 493810 25742 54226 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 60%9437992 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 113965 170670 171155 100911186 140547 25287 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME DATABASE ID RELEASE 60%9438182 Gamma-carboxylation of protein precursors 81750 306608 25295 24946 81716 260320 29251 SUMOYLATION OF RNA BINDING PROTEINS%REACTOME DATABASE ID RELEASE 60%9439108 SUMOylation of RNA binding proteins 300259 299706 292085 117021 304862 301442 58958 245922 113929 65274 287830 25573 116555 362281 25281 683983 295692 291874 81738 499974 113975 25497 362335 60373 53372 294429 SIGNALING BY ERBB2%REACTOME%R-RNO-1227986.1 Signaling by ERBB2 24185 84427 29496 307483 83805 24680 102552659 681260 432361 64156 81504 25513 299331 313845 297173 50522 293621 298787 498837 60450 301333 690919 362814 100912032 112400 24605 361388 24337 24329 287155 366275 117255 59323 85385 64022 59325 25433 296121 24525 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME%R-RNO-5654221.1 Phospholipase C-mediated cascade; FGFR2 54250 25443 25444 170579 25317 170583 29348 29349 25738 25022 29368 116499 60662 170633 66017 170700 60464 CHROMATIN MODIFYING ENZYMES%REACTOME DATABASE ID RELEASE 60%9438885 Chromatin modifying enzymes 362093 360665 100365043 364382 295274 299557 291844 689883 317425 310194 100910200 691488 60421 680403 54282 316328 24829 89820 103694876 100912338 308345 114502 362594 297597 29520 361247 100911617 83833 306969 94201 685179 64647 680312 295384 100911453 444984 363519 306254 290925 288563 315959 83712 306571 26295 296501 310352 81647 361825 304061 297867 689820 363292 303518 282546 303470 303514 363002 312800 309165 309790 300222 310769 361745 58919 102551184 361688 311575 301020 29512 366980 171379 680097 83724 295277 100912489 313929 364723 291159 102548682 100360950 500351 679983 309452 684797 691496 361925 102557184 29511 100364835 296732 306945 100359692 81736 291157 RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME%R-RNO-6807505.1 RNA polymerase II transcribes snRNA genes 286917 171150 103695118 306665 289561 288533 690728 81673 316123 294018 83828 287608 103690054 310784 306347 364834 306516 361365 303918 83830 81674 292778 689116 690966 305120 291736 304758 309200 362110 117017 117526 316216 83503 315291 103689975 171068 361605 298688 102549712 304204 298681 362088 691379 361988 298075 300782 691501 311414 498109 100361574 500715 289382 308472 296102 24790 290322 362537 363633 363227 308837 362813 360589 100912534 361057 311591 309918 DIGESTION OF DIETARY CARBOHYDRATE%REACTOME DATABASE ID RELEASE 60%9438374 Digestion of dietary carbohydrate 24203 116569 497039 497756 HATS ACETYLATE HISTONES%REACTOME%R-RNO-3214847.1 HATs acetylate histones 100365043 362093 295274 100910200 310194 691488 680403 316328 24829 100912338 114502 362594 297597 361247 306969 64647 680312 363519 315959 83712 306571 26295 296501 310352 81647 363292 303470 303514 309790 300222 102551184 311575 680097 295277 83724 100912489 313929 364723 291159 102548682 100360950 500351 679983 684797 691496 102557184 100364835 306945 100359692 291157 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%R-RNO-1483206.1 Glycerophospholipid biosynthesis 691810 170670 296623 691813 361676 364380 363024 24913 289733 498741 287644 362261 29692 114561 298579 291793 362249 691905 294255 296130 24197 100911615 295631 29526 310773 311341 297694 690610 680971 316039 690388 290567 295417 89841 288322 367308 29254 304474 100910990 366196 308309 317456 84497 361467 171155 170919 361694 100359680 287467 287366 296091 361686 100359675 29510 362058 114101 363521 362434 312828 363159 681361 303698 302425 362972 678749 314075 307641 116549 81925 295305 83817 362039 365962 361433 306582 286936 311821 502749 362866 81650 84470 29194 360426 293620 313997 361401 103689982 313087 29359 406165 294324 252900 85311 290843 29367 192260 24653 360843 296128 679692 314824 29653 313977 305166 316737 298504 687071 362702 691478 25096 25511 293150 140544 60666 29354 25097 296048 305816 NRCAM INTERACTIONS%REACTOME%R-RNO-447038.1 NrCAM interactions 497815 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%R-RNO-1169410.1 Antiviral mechanism by IFN-stimulated genes 100912571 501116 688288 361628 298573 25124 116725 300756 292892 117045 25738 301000 295704 306204 287436 84598 363275 367264 297481 50689 312688 298693 24667 303831 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%R-RNO-2162123.1 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 59103 102556347 307092 171516 58962 311865 367808 362809 29527 25526 191574 25527 291283 100360507 24693 24886 TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 60%9439170 Termination of translesion DNA synthesis 316344 116468 288003 100147704 301000 300795 681260 25737 291526 64156 304528 494338 289758 298693 59102 59294 50522 316235 287524 498837 307905 361698 100912032 89809 296883 295704 288414 ORGANIC ANION TRANSPORTERS%REACTOME%R-RNO-428643.1 Organic anion transporters 363103 84487 681896 114613 116638 500820 170943 100911440 309111 266767 RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME%R-RNO-5693565.1 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 64557 100910954 64012 100909750 301442 497672 308669 309595 290631 361815 311860 64156 65179 316794 368002 500987 290997 362704 287927 50522 307766 306257 362827 114212 102551184 300711 64046 680097 85482 295277 100912489 364723 681260 156826 25573 102548682 116554 100360950 301128 500351 29722 296099 289468 313539 680537 313027 679983 498837 116725 100912032 102557184 LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME%R-RNO-3134973.1 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 292892 54244 METHYLATION%REACTOME%R-RNO-156581.1 Methylation 24297 24267 81522 690050 290947 114846 29443 300691 293700 288309 140925 25331 683630 171347 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 60%9437848 Metabolism of polyamines 291983 501620 289924 289990 58854 307821 29425 308652 25698 25257 58961 83806 287670 29675 29221 29671 29215 29670 24968 24967 25581 302642 29666 117263 117262 364814 290206 689588 161475 85492 287063 83499 305177 298227 29614 298934 24314 29593 29669 288912 24609 689852 501454 303353 287716 29668 84596 292766 293589 291640 24264 29677 29672 365388 100912604 81827 298607 81640 287772 303563 287984 25611 311078 497840 94198 29630 296651 408248 25502 363469 306574 PEPTIDE HORMONE METABOLISM%REACTOME DATABASE ID RELEASE 60%9438553 Peptide hormone metabolism 64632 171101 252881 60627 59301 171455 116654 24590 60449 25447 25040 24506 24505 286924 290257 298786 24952 24504 29200 64549 294698 25204 252929 685451 24391 25329 299903 302526 294075 302813 266607 25627 266758 25653 680782 25253 498012 25608 24310 24482 290963 25121 306515 293142 24715 65036 301265 54242 305287 65166 116700 309533 171562 24179 25669 24664 50556 245709 100911734 RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-RNO-5693568.1 Resolution of D-loop Structures through Holliday Junction Intermediates 64557 290805 497976 64046 499870 64012 499966 303375 306734 291787 85482 497672 497856 308755 360254 361836 293452 498119 689055 298884 302953 102551085 293678 287634 293489 300711 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 60%9437981 Cytochrome P450 - arranged by substrate type 24297 24303 24307 24298 24300 24306 24294 25086 290623 313375 29295 313373 56266 25243 25242 353498 154985 25690 286963 500892 81924 100910877 29441 362782 685222 25642 298423 100910127 308190 29189 361631 292728 266761 286904 54246 114700 83724 313929 25053 286953 312495 25429 299566 503122 25527 25426 308445 25428 171352 171522 25427 361523 310848 252931 100361492 301264 313786 50549 79122 100910462 25279 25271 499353 266674 60351 24296 24664 24886 25147 103691072 266684 FIBRONECTIN MATRIX FORMATION%REACTOME%R-RNO-1566977.1 Fibronectin matrix formation 25661 CELLULAR RESPONSE TO HEAT STRESS%REACTOME DATABASE ID RELEASE 60%9439089 Cellular response to heat stress 116590 685055 29753 287871 50689 59102 56718 54244 299331 301252 113906 289014 116643 300711 53372 64226 294429 84581 24245 300259 293103 299706 297994 171361 286899 292085 117021 293524 304862 303536 58958 103689963 24246 245922 113929 690038 65274 25420 287830 116555 361167 362281 25281 361384 683983 295692 291874 81738 689955 499974 287524 113975 367808 25497 362809 362335 24963 25400 103690404 296883 292887 260321 362293 79245 81800 171140 306007 366734 288444 NONSENSE-MEDIATED DECAY (NMD)%REACTOME DATABASE ID RELEASE 60%9438843 Nonsense-Mediated Decay (NMD) 64156 117281 100360057 367195 100360619 100911847 81729 103694903 287113 365215 298075 24420 100911685 684558 681012 360855 307503 100125373 361176 681260 291615 287522 501582 287596 688288 24672 498837 100912032 298385 117104 103692785 140655 287417 360572 313449 292964 367865 689116 103690821 100912571 367265 100910180 294282 690303 29236 100360647 100911575 140662 100364265 100360841 103690015 684988 691531 140661 295284 361109 64640 29283 29284 103692831 28298 100360679 26962 64302 103693375 290641 689284 362041 100360117 296709 103694404 317646 29288 81767 29282 81763 100360522 81768 81765 81769 64205 311120 301299 100362830 690468 314652 81775 81770 29752 64638 81776 25348 306079 103694169 65139 297756 100912182 300079 25347 682793 100910370 685963 124440 306926 687780 29258 100359922 161477 65043 25538 499782 100361079 RMTS METHYLATE HISTONE ARGININES%REACTOME%R-RNO-3214858.1 RMTs methylate histone arginines 364382 171379 680097 60421 89820 295277 103694876 100912489 364723 100911617 102548682 83833 94201 685179 100360950 500351 295384 100911453 444984 306254 290925 288563 679983 361925 102557184 361825 297867 296732 303518 282546 363002 310769 361745 58919 102551184 301020 366980 SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME DATABASE ID RELEASE 60%9438767 Synthesis of dolichyl-phosphate-glucose 295051 299346 SIGNALLING TO ERK5%REACTOME%R-RNO-198765.1 Signalling to ERK5 100912585 114509 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%R-RNO-198725.1 Nuclear Events (kinase and transcription factor activation) 116590 300980 689314 361565 81771 501560 498003 50689 117281 314384 24672 24673 100912585 315305 114509 117269 315648 81649 116663 100363500 289014 103694903 81646 60587 309957 THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME%R-RNO-8852276.1 The role of GTSE1 in G2 M progression after G2 checkpoint 291983 114851 100910954 289924 289990 58854 307821 29425 64156 406168 83806 299331 25203 287670 29675 301252 50522 29671 29670 24968 25581 24967 29666 117263 117262 364814 290206 161475 85492 83499 29614 29669 689852 303353 681260 287716 29668 292766 54237 29677 29672 300126 365388 81827 498837 287772 114764 100912032 287984 311078 94198 29630 296651 408248 TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME DATABASE ID RELEASE 60%9438403 Transport of connexins along the secretory pathway 24392 NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-112310.1 Neurotransmitter release cycle 290567 60442 83589 116470 287609 25550 29642 79213 60377 25558 79212 83612 24803 29253 25716 29483 64832 29503 85426 362876 293645 689955 64830 50676 24380 24379 140592 116638 140591 25531 84556 366432 79130 171163 84012 81632 497009 85327 291133 ACYL CHAIN REMODELLING OF PS%REACTOME%R-RNO-1482801.1 Acyl chain remodelling of PS 362039 690388 691905 29359 362434 24913 85311 295631 498741 296091 29526 361686 24653 311341 29692 314824 29354 296048 316039 298579 CALNEXIN CALRETICULIN CYCLE%REACTOME%R-RNO-901042.1 Calnexin calreticulin cycle 364398 499751 315000 300445 296304 50522 314352 297504 498837 360967 294862 100912032 29144 293721 171129 681260 407784 64156 362891 64202 84508 289085 APOPTOTIC EXECUTION PHASE%REACTOME%R-RNO-75153.1 Apoptotic execution phase 499156 29477 288064 305884 501266 60374 307562 29395 116685 293852 25402 317589 83502 83584 291755 114214 291752 25318 64204 498988 24170 498072 114114 81818 361092 298534 25614 64159 103689977 64044 81762 83527 367786 60371 316164 64026 170538 85420 296654 24205 24917 HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME%R-RNO-5685938.1 HDR through Single Strand Annealing (SSA) 290805 64557 64046 100362315 499870 363924 100361529 64012 116468 306734 685055 301014 291787 85482 288003 498411 294800 100909750 310034 497672 497856 308755 315969 361836 311860 304528 59102 292673 297561 287524 296883 288414 300711 ION TRANSPORT BY P-TYPE ATPASES%REACTOME%R-RNO-936837.1 Ion transport by P-type ATPases 317599 24245 367086 24244 170699 64190 171496 24246 288026 29693 302422 63847 683667 29600 362645 24941 63848 64672 685152 29639 24217 116831 24215 24218 24213 291555 24216 24211 24214 24212 29598 25400 29599 24242 290673 171028 303856 171140 25650 25391 29132 360932 25390 ARACHIDONIC ACID METABOLISM%REACTOME%R-RNO-2142753.1 Arachidonic acid metabolism 24297 679520 307092 79242 171516 65030 24306 287424 290623 313375 313373 56266 25290 299732 266604 100360507 24693 102556347 59103 58962 298423 312086 84024 29527 289014 81639 29624 100911581 286904 296851 114097 25526 503122 24653 25527 291283 25426 287454 29328 310848 311865 50549 367808 362809 29347 191574 94199 266674 24296 24886 FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME%R-RNO-77042.1 Formation of editosomes by ADAR proteins 81635 25367 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 60%9437859 Lysine catabolism 300723 29416 364975 298942 291450 360975 103690164 100169747 299201 303272 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME DATABASE ID RELEASE 60%9438268 Cytosolic sensors of pathogen-associated DNA 299827 25493 362896 314336 292892 310461 499069 64156 690966 292545 293774 54244 50522 498840 301059 362858 310685 311487 300088 309361 83503 361640 309165 366277 301246 84351 64046 681260 361102 498109 100361574 685465 690254 306012 308901 81722 287707 313264 309452 498837 100912032 309295 100912534 81736 25742 305751 81525 54226 304859 PI-3K CASCADE:FGFR4%REACTOME%R-RNO-5654720.1 PI-3K cascade:FGFR4 54250 25444 314850 25317 170583 29349 361388 25114 29368 116499 25622 170582 81504 25513 66017 170700 60464 LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME DATABASE ID RELEASE 60%9439245 Lysosomal oligosaccharide catabolism 310864 246136 361378 SCAVENGING BY CLASS A RECEPTORS%REACTOME DATABASE ID RELEASE 60%9439032 Scavenging by Class A Receptors 361289 367391 54225 25728 498854 366588 362862 64023 64202 25081 498638 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%R-RNO-392451.1 G beta:gamma signalling through PI3Kgamma 24514 366508 24400 246144 24185 85243 24497 25326 652957 116630 140924 114103 116562 84477 81745 81504 25513 297173 25704 298947 171081 497931 497932 85385 84598 25746 CLEC7A (DECTIN-1) SIGNALING%REACTOME%R-RNO-5607764.1 CLEC7A (Dectin-1) signaling 291983 303024 29748 289924 25493 289990 361831 308267 58854 307821 29425 64156 296390 64044 24674 83806 282817 117553 502902 24494 360640 287670 64171 29675 313121 50522 29671 29670 81678 311658 24968 679539 24967 100361818 25581 100360982 29666 361509 361400 117263 117262 170538 364814 309361 361765 290206 309165 315139 311245 161475 85492 84351 83499 24244 100910771 25679 317546 29614 25262 29669 689852 83805 303353 100912618 681260 287716 29668 81745 292766 362356 29677 29672 365388 81827 309452 498837 83477 287772 116725 287280 100912032 287984 311078 24242 309295 94198 29630 296651 81736 408248 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 60%9438303 Frs2-mediated activation 291983 171109 24514 246145 289924 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 58854 102552659 170668 29425 65179 24408 25167 64030 59109 24716 24410 24412 117281 24446 498576 29675 29671 29670 29376 24968 24967 29372 690919 25704 112400 29666 24337 24329 117263 117262 116663 364814 290206 24592 103694903 64022 161475 360814 24703 83499 24245 24244 25267 309179 29614 29496 295234 29211 689852 64363 24497 652957 116630 140924 114103 295347 24246 303353 289257 84423 84422 29668 29495 25614 292766 691318 25266 362572 360573 60427 24672 309168 365388 81827 24673 288924 171081 24242 94198 291245 296072 29630 81511 296651 408248 304893 24586 25746 116590 307821 50689 85492 83613 312754 300980 66023 25525 25326 314612 305203 312664 25136 432361 287716 114858 58960 192126 29542 192213 25467 192117 364052 246150 315648 305614 299147 288589 25400 25150 59323 25344 171140 84598 29613 170577 25054 59325 25433 25676 310533 64156 50522 25581 287942 89807 310738 89804 83805 681260 64159 498837 100912032 362045 56011 79114 81504 170633 83806 170700 313845 54250 287670 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 25114 25738 25022 29368 116499 60662 85385 170582 24525 66017 60464 29669 24225 81737 25730 54245 100911248 29677 63881 29672 287772 287984 311078 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 60%9438048 PLC beta mediated events 24244 25679 25262 116590 50664 25238 25686 54223 81664 25643 25521 365901 24680 363143 25050 25740 25289 305509 25725 24653 64532 64508 293508 84420 25636 286924 29322 29699 24679 25031 29691 24654 81678 302950 24681 29241 24242 100363500 170538 81646 SODIUM PROTON EXCHANGERS%REACTOME%R-RNO-425986.1 Sodium Proton exchangers 24782 317170 192215 24785 302863 24783 311651 24784 363115 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%R-RNO-428790.1 Facilitative Na+-independent glucose transporters 25351 308028 296600 25139 85256 65197 501925 24778 170580 366251 INTERLEUKIN-7 SIGNALING%REACTOME%R-RNO-1266695.1 Interleukin-7 signaling 24918 171379 294797 291159 84598 25326 691496 140924 304061 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME%R-RNO-419812.1 Calcitonin-like ligand receptors 24241 58966 399475 56820 171519 25029 25026 24476 58965 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%R-RNO-2173793.1 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer 29417 361831 681260 64156 500715 84576 500695 641452 24790 295062 304758 300947 50522 29357 365894 680111 498837 114208 499929 297893 300813 362110 100912032 363445 84396 25631 81920 360801 315291 100360427 361178 116651 25591 316742 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 60%9438049 G-protein mediated events 24244 25679 25262 116590 50664 25238 25686 54223 81664 25643 25521 365901 24680 363143 25050 25740 25289 305509 25725 24653 64532 64508 293508 84420 25636 286924 29322 29699 24679 25031 29691 24654 24611 81678 302950 24681 29241 24242 100363500 170538 81646 P75NTR REGULATES AXONOGENESIS%REACTOME%R-RNO-193697.1 p75NTR regulates axonogenesis 310738 24596 297173 83765 315691 450224 29409 360678 MET ACTIVATES PTPN11%REACTOME%R-RNO-8865999.1 MET activates PTPN11 24446 25622 81504 361388 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME DATABASE ID RELEASE 60%9439042 SHC-related events triggered by IGF1R 313845 24482 293621 85385 81504 24525 24483 24605 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME DATABASE ID RELEASE 60%9439173 Phospholipase C-mediated cascade; FGFR3 25738 54250 29368 116499 25444 60662 25317 170583 29349 84489 66017 60464 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 60%9438638 CD28 dependent Vav1 pathway 25408 25660 64465 100910732 29431 29433 25150 310695 81504 29432 56822 363875 25156 BILE ACID AND BILE SALT METABOLISM%REACTOME%R-RNO-194068.1 Bile acid and bile salt metabolism 307092 171516 303497 79111 83724 365410 313929 79244 252898 25429 83569 80899 362360 170588 291283 296461 25440 65192 81924 25428 246211 58978 362782 84608 298369 80900 301264 50572 25284 309527 191574 311129 29500 25271 170698 24777 29725 60351 192242 502348 PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME%R-RNO-1483196.1 PI and PC transport between ER and Golgi membranes 114561 ACYL CHAIN REMODELLING OF PE%REACTOME DATABASE ID RELEASE 60%9438949 Acyl chain remodelling of PE 362039 690388 360426 313997 691810 691905 29359 691813 364380 362434 24913 289733 295631 498741 296091 29526 24653 311341 297694 314075 29692 29354 296048 298579 MRNA EDITING: A TO I CONVERSION%REACTOME%R-RNO-75064.1 mRNA Editing: A to I Conversion 81635 25367 DNA REPLICATION INITIATION%REACTOME%R-RNO-68952.1 DNA replication initiation 100362333 299112 304573 85242 301323 246327 MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME%R-RNO-8949215.1 Mitochondrial calcium ion transport 298203 296588 171433 353231 64198 114766 364601 307350 83529 100910779 301418 294560 365567 295462 114217 25344 498185 ZINC TRANSPORTERS%REACTOME%R-RNO-435354.1 Zinc transporters 58976 306009 298786 291733 25362 294281 305846 294698 314637 299903 361986 300051 295455 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 60%9438715 Cation-coupled Chloride cotransporters 308069 171373 29501 25065 54300 83629 691209 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%R-RNO-416476.1 G alpha (q) signalling events 192649 192648 64636 171101 53949 25238 691774 29581 29597 25380 29595 81821 25723 24889 54248 24938 292794 171371 360579 690230 292413 497196 314904 24952 292419 100361138 60337 378939 192223 25605 140866 170538 85420 25107 287910 688705 24247 25593 299242 500317 365228 84009 66025 192206 25194 192205 117264 25007 500157 681706 24323 24324 309207 299757 24326 304289 305795 499913 64042 29254 25187 310192 288001 25229 24816 690158 24903 89823 54293 29413 29412 81638 366274 29462 24180 366270 25706 310327 81749 24179 379044 497978 54226 78964 100909783 25666 24400 59301 302378 308408 59264 282822 60395 361076 24808 289076 24806 25513 24807 102553138 25031 116498 368088 690198 294394 84583 29251 25570 25439 29636 25569 170926 24221 24414 116744 81668 498609 25504 24953 25298 25637 81509 25679 25262 100126231 100360071 29180 25265 50672 24260 116677 767613 289023 29191 84022 499194 29322 89788 301086 57305 81662 317219 24654 25320 64107 266607 81666 309242 58949 59293 25652 100909648 314480 114098 114099 367745 314386 63887 25245 24448 24659 25342 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%R-RNO-1362409.1 Mitochondrial iron-sulfur cluster biogenesis 360826 290985 84594 102550385 100911034 500694 362776 288740 313786 499335 79122 29189 NICOTINATE METABOLISM%REACTOME DATABASE ID RELEASE 60%9437986 Nicotinate metabolism 81506 289095 361185 297508 499330 303905 316062 300691 29527 367323 25668 58813 365699 25527 361751 295229 100125370 500820 353255 315085 293504 100912521 298653 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-RNO-166058.1 MyD88:Mal cascade initiated on plasma membrane 303024 116590 25493 689314 363855 314322 81771 308267 363520 64156 291912 498003 296390 50689 25272 117281 314384 313121 287398 50522 500133 100912585 679539 315305 305549 114509 81647 301059 81649 362418 305451 305835 116663 100363500 309361 361765 289014 81646 103694903 309165 315139 311245 84351 114495 100910771 317546 50658 361565 300980 300447 100912399 116596 116667 303200 315994 100912618 681260 501560 116554 24516 362356 81722 287707 24672 309452 24673 498837 315648 117269 116725 100912032 287280 309295 81736 362491 25742 60587 305751 309957 81525 304859 54226 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 60%9438993 Pre-NOTCH Expression and Processing 29492 54281 65165 25496 56761 406162 CELL-CELL JUNCTION ORGANIZATION%REACTOME%R-RNO-421270.1 Cell-cell junction organization 307505 83502 81679 84006 140581 301112 307237 308417 314259 362279 116479 29163 307618 497229 360687 84407 288124 498515 307799 311163 25066 29162 26955 192183 192248 361432 117048 25409 360652 498281 81918 29181 116777 83501 360882 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME DATABASE ID RELEASE 60%9438069 Organelle biogenesis and maintenance 690441 641434 362749 94271 117281 299331 245958 245965 24244 309451 24242 114089 79120 100911417 309156 29214 114017 25050 83474 308443 363760 171044 299246 362142 361930 315484 316102 300754 113948 680991 691918 362504 361634 29167 680477 305909 305882 29479 64462 293844 100911033 171082 300963 363055 83572 81740 315423 367153 116659 500069 291540 294010 140734 690209 311191 192228 299850 64158 316531 309692 296554 100362495 311529 305288 311802 311573 286919 360672 299730 192241 58822 310344 83836 103690034 290626 246150 305002 114764 361789 311886 29213 60347 117103 29754 85258 287612 64632 363272 307724 252881 303968 60627 24650 171455 116654 170714 314523 304740 309126 302661 114482 300062 313365 308064 100362124 305467 683722 252921 103690077 685284 499814 288585 294696 298767 503018 361415 363286 287541 312651 373066 314393 300675 299209 363544 500571 362265 500086 295106 24679 81646 500350 293149 363646 296551 683519 298517 297459 309140 287126 294963 367117 362517 290850 688912 363187 295224 309440 288621 25309 288916 361883 113958 689271 291206 289143 498406 64360 360594 301371 294672 297799 299938 100363502 362216 293054 680747 296134 689025 289491 303673 362094 171061 301250 299628 361473 361005 100361098 301552 287356 500199 301352 297372 294767 362388 691075 297601 303685 303746 287635 294230 292244 305287 499185 25411 292758 301249 83686 304037 100910528 56281 50556 100363539 84593 245709 100911734 103692169 29753 304486 56010 292811 304007 313170 309486 311349 308923 303915 296136 266809 680407 313749 117515 293148 100912537 7066252 313067 7066251 287836 364656 310653 289469 293754 290632 299743 311903 295238 26197 293666 26196 497876 296995 361037 309176 301240 297727 287962 300974 100363500 363023 297334 103691922 103693219 300677 361596 84581 306840 24787 311569 140608 114630 304539 363735 293615 499883 103689963 24399 81830 171374 171375 54237 287383 361727 366872 300880 100911746 295654 305918 305349 84392 289168 296284 85248 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 60%9437901 Formation of the ternary complex, and subsequently, the 43S complex 296302 29288 140655 362952 681260 100362830 292148 81775 293427 29752 81776 292762 299027 25348 300069 294282 293484 288516 29236 65139 100360647 297756 498837 103690015 684988 298700 100912032 691531 295975 299872 29284 691947 100911847 687780 29258 100360679 54318 100911110 161477 302697 25538 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME%R-RNO-380284.1 Loss of proteins required for interphase microtubule organization from the centrosome 29753 304740 302661 114482 29214 308064 305467 683722 56010 252921 299331 117281 24679 680991 691918 362504 361634 29167 680477 305909 305882 29479 64462 293844 100911033 300963 363055 83572 81740 315423 367153 116659 500069 291540 294010 690209 311191 192228 64158 299850 316531 309692 296554 100362495 311529 305288 311802 311573 54237 286919 360672 299730 58822 310344 83836 103690034 290626 305002 246150 114764 311886 29213 60347 84593 IRON UPTAKE AND TRANSPORT%REACTOME%R-RNO-917937.1 Iron uptake and transport 64678 297566 689779 25715 117596 297797 291969 25490 296981 64156 170840 288371 117152 297932 116455 50522 303333 366545 117240 289407 362802 94170 685232 25319 29292 170667 79239 100360087 288562 29199 291470 368044 305424 50655 683955 681260 295669 305142 305886 289453 29757 312382 64831 299159 362356 498837 293650 100912032 287280 24268 116664 170496 24825 436582 83615 299971 24451 SIGNALLING TO STAT3%REACTOME%R-RNO-198745.1 Signalling to STAT3 24225 81737 25730 310738 29613 25054 59109 25125 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME DATABASE ID RELEASE 60%9438989 A tetrasaccharide linker sequence is required for GAG synthesis 116673 25615 58920 293722 25216 691984 58982 25592 25181 64544 364675 64134 29139 171517 298690 50568 114122 317322 25393 81651 24771 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME DATABASE ID RELEASE 60%9439210 HDR through Homologous Recombination (HRR) 64557 497976 499870 100361529 64012 116468 303375 685055 291787 288003 498411 294800 310034 497672 497856 315969 25737 64156 289758 59102 293452 498119 689055 298884 50522 316235 302953 102551085 89809 293678 362288 287634 293489 300711 290805 64046 100362315 363924 499966 306734 301014 85482 308755 360254 361836 681260 304528 59294 287524 498837 361698 100912032 296883 288414 INTESTINAL LIPID ABSORPTION%REACTOME%R-RNO-8963678.1 Intestinal lipid absorption 432367 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%R-RNO-2022923.1 Dermatan sulfate biosynthesis 29139 50568 114122 365583 297865 25393 361450 81651 691394 58982 25181 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 60%9438673 Nitric oxide stimulates guanylate cyclase 308899 29691 171115 497757 25262 25206 66012 497963 29516 25202 81743 191569 25523 140928 24600 25310 63885 24599 24598 50678 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 60%9437913 RNA Polymerase I Transcription Initiation 171150 294693 117535 303241 361724 310511 498109 100361574 84389 690966 84576 100362346 304714 499766 361798 84577 308415 288651 64520 83712 502227 290669 266713 297893 310614 362834 25574 363017 117526 690450 680493 306274 361420 83503 100912534 294236 313245 313048 301246 83582 83581 361580 362728 361784 291703 KERATINIZATION%REACTOME DATABASE ID RELEASE 60%9439255 Keratinization 450228 501725 300242 501721 363678 100361739 366991 680060 100363287 303530 287679 287678 450229 287675 450227 100359826 690431 407762 303528 303527 363739 497995 407759 306871 450225 689927 360626 407761 360623 100363136 407760 303523 684589 406227 266717 100361702 406226 100361571 407757 680396 287697 683613 501720 690478 303519 681126 294853 100365646 501765 687631 287702 100363184 287700 102552748 680328 100361664 683212 680071 100364550 300248 300247 287701 690460 288297 100910814 304822 100364613 407758 100359886 287699 287698 361319 100911681 302934 299587 307562 24332 100910851 498087 60335 408215 291755 295190 291752 292949 303687 100910942 295625 310575 292848 100911797 288067 291760 408235 408214 307563 288075 293619 60583 291754 689230 308564 308562 100362978 308565 81679 25626 315323 450230 315318 103694398 315320 TELOMERE EXTENSION BY TELOMERASE%REACTOME DATABASE ID RELEASE 60%9438197 Telomere Extension By Telomerase 301965 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 60%9438787 Ionotropic activity of kainate receptors 24244 25252 24242 29559 54257 29495 24407 298521 58948 553106 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME DATABASE ID RELEASE 60%9439060 Transcriptional regulation of pluripotent stem cells 500562 294562 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME%R-RNO-69298.1 Association of licensing factors with the pre-replicative complex 313138 50522 498837 399489 360621 311562 313479 291137 291105 100912032 292071 681260 362304 301430 64156 684111 295596 CTLA4 INHIBITORY SIGNALING%REACTOME%R-RNO-389513.1 CTLA4 inhibitory signaling 25408 312754 309179 24672 81515 24185 24673 315648 299147 63835 83805 25150 25622 81745 103694903 691318 56822 24884 117281 DNA DOUBLE STRAND BREAK RESPONSE%REACTOME DATABASE ID RELEASE 60%9437819 DNA Double Strand Break Response 64557 100910954 64012 100909750 301442 497672 308669 309595 290631 361815 311860 64156 65179 316794 368002 500987 290997 362704 287927 50522 307766 306257 362827 114212 102551184 300711 64046 680097 85482 295277 100912489 364723 681260 156826 25573 102548682 116554 85245 100359600 100360950 301128 500351 29722 296099 289468 313539 680537 313027 679983 498837 116725 100912032 102557184 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 60%9437816 G2 M DNA damage checkpoint 64557 100910954 100361529 116468 64012 685055 288003 291787 313017 498411 294800 29753 301442 25576 310034 497672 497856 298795 56011 315969 56010 308669 309595 290631 361815 25577 316794 500987 59102 290997 308937 362704 25203 287927 362827 114212 102551184 300711 290805 64046 100362315 363924 306734 680097 301014 85482 295277 100912489 308755 364723 361836 304528 102548682 100360950 54237 500351 296099 289468 679983 287524 680537 116725 102557184 296883 288414 307511 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 60%9437860 Citric acid cycle (TCA cycle) 361596 94173 157074 298942 363061 360975 361071 299201 24368 25179 289217 310378 170587 79250 114096 362404 81829 298596 PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME%R-RNO-5576886.1 Phase 4 - resting membrane potential 29712 156873 117052 59324 276720 116649 100909725 29553 116491 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 60%9438536 Apoptosis induced DNA fragmentation 288064 29395 25402 114214 498988 498072 24917 CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME DATABASE ID RELEASE 60%9438282 CLEC7A (Dectin-1) induces NFAT activation 24244 29748 24242 25679 25262 81678 311658 100361818 24674 361400 ADENOSINE P1 RECEPTORS%REACTOME DATABASE ID RELEASE 60%9438699 Adenosine P1 receptors 29316 100363178 25369 29290 100911796 25370 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME DATABASE ID RELEASE 60%9439300 TFAP2 (AP-2) family regulates transcription of cell cycle factors 362280 311807 SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-RNO-2142712.1 Synthesis of 12-eicosatetraenoic acid derivatives 287454 29328 287424 81639 PKB-MEDIATED EVENTS%REACTOME%R-RNO-109703.1 PKB-mediated events 25233 300253 26954 290291 301574 362045 83803 24185 29516 65248 295234 360776 56011 24855 303605 64562 287871 56718 310091 100361543 100912571 301518 501146 298514 116636 83840 295357 117045 78975 292887 100909655 117044 117043 60445 308869 297960 25435 64226 NEUROFASCIN INTERACTIONS%REACTOME%R-RNO-447043.1 Neurofascin interactions 116690 497815 306570 83841 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%R-RNO-76005.1 Response to elevated platelet cytosolic Ca2+ 89811 56782 246328 360950 24854 24628 361196 360942 295703 686539 364206 309186 81804 114111 305679 360457 116635 294643 308291 100359512 304805 299052 81803 24446 24791 59086 299277 24681 81634 499985 103690020 445442 54249 24617 85253 24944 24244 25717 24680 25266 288001 24903 299276 24482 24189 81809 24825 24242 291245 84491 24483 170924 54226 25373 100365047 25524 293860 140656 29184 83785 25023 29186 246358 25081 116669 313494 24366 25661 361969 24367 29302 685269 114095 84590 304983 307986 25673 305021 317191 316531 302470 25651 300988 24786 113947 24936 140594 293886 296488 311795 100911881 309609 25358 100912012 100911545 297073 363104 500152 360918 293676 171016 307396 81750 363195 64312 54404 58935 309647 287774 60327 299909 24153 498299 63836 116662 116510 245955 312159 50693 COMPLEX I BIOGENESIS%REACTOME%R-RNO-6799198.1 Complex I biogenesis 100363268 293114 296190 297990 100912599 81728 299643 303922 299310 7066248 301458 7066247 301427 499529 362344 362495 316632 315167 291660 29478 684509 293130 288088 361385 26194 26199 295923 679739 301123 25488 26193 299739 678759 299008 293991 56769 64539 293453 26201 300447 299954 293652 296086 7066258 7066257 26203 7066256 26202 7066254 680288 293655 294973 298748 300091 294964 289218 363441 100911483 681418 362837 362440 362588 GLUCONEOGENESIS%REACTOME%R-RNO-70263.1 Gluconeogenesis 24849 100911625 24190 114508 81829 24401 170943 25636 29743 25104 299052 24959 24362 25721 24551 292804 24191 25438 24189 362282 24644 24333 24334 66020 24638 64201 C6 DEAMINATION OF ADENOSINE%REACTOME DATABASE ID RELEASE 60%9438006 C6 deamination of adenosine 81635 25367 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 60%9438247 Signalling to ERKs 291983 171109 24514 246145 289924 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 58854 102552659 170668 29425 65179 24408 25167 64030 59109 24716 24410 24412 117281 24446 498576 29675 29671 29670 29376 24968 24967 29372 690919 25704 112400 29666 24337 24329 117263 117262 116663 364814 290206 24592 103694903 64022 161475 360814 24703 83499 24245 24244 25267 309179 29614 29496 295234 29211 689852 64363 24497 652957 116630 140924 114103 295347 24246 303353 289257 84423 84422 29668 29495 25614 292766 691318 25266 362572 360573 60427 24672 309168 365388 81827 24673 288924 171081 24242 94198 291245 296072 29630 81511 296651 408248 304893 24586 25746 116590 307821 50689 85492 83613 312754 300980 66023 25525 25326 314612 305203 312664 25136 432361 287716 114858 58960 192126 29542 192213 25467 192117 364052 246150 315648 305614 299147 81757 288589 25400 25150 59323 25344 29622 171140 84598 29613 170577 116478 25054 116546 59325 25433 25676 291713 310533 689314 64156 50522 25581 287942 289014 89807 310738 89804 83805 681260 64159 498837 100912032 362045 56011 79114 81504 170633 83806 170700 313845 54250 287670 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 25114 25738 81649 25022 29368 116499 60662 85385 170582 24525 66017 60464 29669 315994 24225 81737 25730 54245 100911248 29677 63881 29672 287772 287984 311078 THYROXINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 60%9438521 Thyroxine biosynthesis 79107 116700 266807 114613 308129 54314 25653 SDK INTERACTIONS%REACTOME DATABASE ID RELEASE 60%9438592 SDK interactions 360652 PROCESSING OF SMDT1%REACTOME DATABASE ID RELEASE 60%9439325 Processing of SMDT1 298203 296588 171433 353231 64198 114766 364601 307350 100910779 301418 294560 365567 295462 114217 25344 GABA RECEPTOR ACTIVATION%REACTOME%R-RNO-977443.1 GABA receptor activation 29712 140675 29713 170847 29695 25743 24400 117052 83633 116560 25686 54223 25451 81664 60449 29705 81667 289606 29694 25643 81657 192258 25450 25289 305509 114120 64532 116649 50599 114118 64508 114119 84420 114117 79218 286924 690825 24611 680149 302950 245986 29241 29708 65187 29709 29707 24947 29719 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME DATABASE ID RELEASE 60%9438867 N-glycan antennae elongation in the medial trans-Golgi 65196 25547 25478 313536 432392 25197 308511 65271 363040 308757 94273 24390 29582 25329 140568 494342 367252 362275 303923 116700 303100 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 60%9438160 Signaling by NOTCH 84010 311332 29146 681260 64156 679028 500695 303101 54244 50522 297767 498837 65165 25496 56761 406162 289231 100912032 81517 117258 687424 100911293 29492 300802 691658 54281 81751 365872 292788 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%R-RNO-3238698.1 WNT ligand biogenesis and trafficking 316527 362065 140584 293990 84426 287357 361846 24882 288666 316526 114487 25479 114850 303586 303181 24881 64566 315196 116466 282582 500047 291678 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 60%9438681 Acetylcholine regulates insulin secretion 29322 89788 24680 81662 24654 81666 25603 309242 METABOLISM OF RNA%REACTOME%R-RNO-8953854.1 Metabolism of RNA 289924 170538 501688 366468 292884 681062 303353 291615 365684 294595 266605 360917 299805 312227 501515 363221 301513 293408 308311 306492 295707 363603 408200 365388 291841 360629 94198 103692785 140655 287417 360572 292964 367865 103690821 81635 25367 25383 170912 100912571 367265 100910180 294282 29236 29344 100360647 103690064 679140 100911575 140662 300045 313243 100364265 100360841 295050 294975 103690015 684988 300944 691531 366017 100909830 140661 361109 64640 291604 316098 29283 308441 29284 103692831 28298 287436 100360679 26962 64302 103693375 290641 689284 362041 300253 100360117 296709 103694404 317646 29288 81767 29282 81763 100360522 81768 81765 81769 64205 311120 301299 100362830 690468 314652 81775 81770 29752 64638 81776 25348 306079 103694169 65139 297756 100912182 300079 117045 25347 682793 100910370 685963 124440 306926 687780 29258 100359922 161477 65043 25538 499782 100361079 303831 25581 171137 24471 362990 302670 287170 117104 83806 287670 501926 363082 360803 291060 498425 691538 315170 290519 361990 303057 29669 89827 360845 362819 679894 305714 313308 360972 302729 114612 500378 79227 291797 29677 689955 29672 287772 287984 315708 364624 311078 361399 500305 500988 361736 291983 289990 58854 29425 117281 29675 29671 29670 24968 24967 29666 117263 117262 364814 290206 103694903 161475 83499 289693 81781 287113 192246 361859 361522 29614 103689936 680891 302879 689852 298075 310687 100360750 300361 287530 689890 313035 287739 290647 361849 29668 170933 292683 494445 117280 292766 307410 687575 366952 681410 295270 297695 295334 681031 302557 688288 100359574 24672 100911462 81827 311670 298095 85434 684148 306222 360613 140931 679890 365407 100363406 296913 114765 362829 315903 362153 362264 362361 298385 29630 687679 287765 296651 287768 408248 500684 79256 89819 298374 304859 307821 85492 24185 287716 363064 171150 289561 294693 103690054 245976 298508 364834 361365 84389 64156 292778 690966 308415 288651 50522 502227 362394 246216 117017 100360057 367195 100360619 100911847 81729 289014 83503 53372 294429 291703 300259 299706 292085 117021 365215 304862 24420 100911685 684558 681012 58958 287437 360855 245922 25379 307503 113929 100125373 24680 65274 85252 361176 681260 363854 287830 287522 498109 100361574 501582 287596 366163 500695 116555 362281 25281 683983 295692 291874 81738 499974 363633 113975 498837 266713 100912032 25497 362335 100912534 294236 361580 116697 114021 303607 290556 687711 309628 688637 80846 316317 288701 316123 317399 314417 289740 310720 308650 289810 296320 361574 314713 294232 300050 680737 100360664 314545 29678 293505 56011 313744 313167 362152 103689953 295607 319110 309301 171365 293828 361977 311166 85432 81674 313449 100912375 363134 299620 689116 362967 362703 361814 291987 293671 64200 362902 290614 299198 305258 685273 361995 287120 288647 29667 291877 303245 360574 307524 84486 60376 308335 366461 690303 25135 117259 360828 361887 366276 291794 313581 292019 313707 363237 309338 303456 294711 362229 362223 298065 498934 286973 305076 295284 314617 296126 361159 309458 100361269 100360682 297685 291295 690297 297455 317579 361808 289724 362214 300996 686999 362612 361605 361262 313620 296865 60373 361542 362687 290660 312706 290666 292536 365668 314830 84401 292747 309651 305479 102548514 683927 299256 291534 245957 313131 300092 317385 298916 308472 295428 304277 499020 300208 361035 297336 292007 117855 680309 292729 313583 500697 308653 296219 59087 362098 315697 501621 310019 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 60%9437914 RNA Polymerase I Promoter Escape 171150 294693 498109 100361574 84389 690966 304714 308415 288651 502227 266713 25574 363017 117526 690450 680493 361420 83503 100912534 294236 301246 313245 83582 361580 83581 362728 291703 361784 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME DATABASE ID RELEASE 60%9438109 Cell surface interactions at the vascular wall 307811 54225 80878 308995 301229 29364 81683 83509 50687 100909977 64350 81504 100360977 65200 25513 25528 313845 114517 59086 50719 25615 293621 499271 114518 29409 116726 103694877 25027 25441 29251 24605 25622 85385 309684 310392 103690070 24525 25390 296269 25544 290361 103689942 89807 103689938 29741 116673 362248 89804 89805 64025 25661 84427 65037 85243 58920 24796 361873 25518 83580 81613 363930 360746 84551 29476 25599 245962 287009 288521 171577 25404 25651 300519 315610 501872 116479 84591 81515 25246 25216 24214 360918 300339 360606 25021 81750 311144 25150 25406 58935 315509 25650 24771 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%R-RNO-1855167.1 Synthesis of pyrophosphates in the cytosol 94267 500709 311355 680248 688862 367747 501194 306808 499878 294292 50560 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 60%9438390 FGFR4 ligand binding and activation 54250 29368 116499 25444 170582 25317 170583 29349 66017 170700 25114 60464 GLYCOSAMINOGLYCAN METABOLISM%REACTOME DATABASE ID RELEASE 60%9438333 Glycosaminoglycan metabolism 64076 294673 64537 24782 290959 316033 501103 282580 83717 316583 84406 65196 116673 288752 114002 313536 305571 362924 291015 306866 58920 84400 100911750 293722 117267 290638 64507 25592 314771 363040 311215 295934 364675 171517 299907 64468 302489 367166 691394 303218 295443 64152 360630 363618 103690051 25216 691984 360904 116721 684979 24390 25406 293451 64442 367145 494342 362275 297865 303923 307859 64445 304023 81682 24771 103690116 293667 25227 282821 294103 25615 361450 266805 58982 25181 294449 29633 64544 291577 64134 292999 308797 29139 292155 286974 84468 293186 298690 50568 114122 365583 500257 317322 304322 25393 81651 296733 291770 306375 302302 316325 297554 314694 316533 24434 300757 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%R-RNO-157858.1 Gap junction trafficking and regulation 315840 29584 79128 394266 116561 266706 24392 292994 83805 116563 83800 140694 25751 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%R-RNO-3769402.1 Deactivation of the beta-catenin transactivating complex 25233 24185 29417 85252 25520 84576 100362634 503000 25565 84424 499593 25221 161452 362533 304794 299636 246768 297893 65027 312936 290829 295251 361765 691857 300673 290317 289026 24205 140586 293165 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 60%9439028 Mitotic Prophase 24708 81754 299557 306594 307169 317425 300149 116590 103690018 362798 60336 113961 287447 60334 291914 100360828 498266 65158 50689 25203 689820 25023 102551184 53372 56082 294429 25437 114087 300259 299706 60374 680097 362779 292085 117021 304862 295277 100912489 364723 58958 245922 113929 65274 24680 360161 287830 102548682 116555 362281 295107 25281 100360950 362519 54237 683983 295692 313977 500351 291874 81738 499974 679983 113975 102557184 25497 362335 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME DATABASE ID RELEASE 60%9439243 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 140923 290995 100910137 691278 103690163 100359464 300711 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME DATABASE ID RELEASE 60%9438899 O2 CO2 exchange in erythrocytes 103694857 689064 25240 287167 365345 100134871 54231 310218 361619 25632 65207 24779 304805 689035 NUCLEOBASE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 60%9437905 Nucleobase biosynthesis 315150 288051 684425 65156 81643 287420 361663 140946 289276 295088 288259 117544 24240 362329 301005 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME%R-RNO-75953.1 RNA Polymerase II Transcription Initiation 116550 171150 103695118 288533 289561 294693 81673 291773 682902 316123 294018 83828 293345 103690054 310784 171152 100360100 364834 306516 361365 303918 83830 498109 81674 100361574 84389 292778 690966 307485 170844 308415 288651 363633 502227 266713 117017 117526 83503 100912534 294236 361580 291703 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 60%9438003 Processing of Intronless Pre-mRNAs 116697 311670 314417 298075 309338 365407 311166 683927 299256 689116 298916 292683 361605 304277 366952 291877 307524 PHOSPHO-PLA2 PATHWAY%REACTOME DATABASE ID RELEASE 60%9438052 phospho-PLA2 pathway 116590 24653 ANCHORING FIBRIL FORMATION%REACTOME DATABASE ID RELEASE 60%9439036 Anchoring fibril formation 678743 192362 83470 365460 307582 301012 305078 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME%R-RNO-416993.1 Trafficking of GluR2-containing AMPA receptors 84591 81637 308578 65046 24681 140670 29629 84016 29627 60355 24680 29628 116563 25023 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME%R-RNO-77346.1 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 113965 170670 171155 24158 100911186 140547 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME DATABASE ID RELEASE 60%9438541 Epigenetic regulation of gene expression 317399 310511 65261 60571 360905 368002 690966 84486 303539 444984 307766 83712 81822 444985 296653 681740 297705 294287 84350 363017 117526 690450 680493 361420 83503 306817 313245 301246 102551184 83582 83581 362728 361784 100360868 680097 114521 295277 100912489 117056 364723 103693372 680172 498109 100361574 291159 102548682 308911 302553 100360950 500351 679983 691496 102557184 293104 312299 306274 100912534 313048 CELL DIVISION%REACTOME DATABASE ID RELEASE 60%9438149 cell division 29648 304218 314949 361308 63996 290577 29486 305343 313304 315958 315740 290668 UREA CYCLE%REACTOME DATABASE ID RELEASE 60%9437847 Urea cycle 25611 497840 29221 29215 25698 291640 287063 303563 306574 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME%R-RNO-937061.1 TRIF-mediated TLR3 TLR4 signaling 303024 116590 25493 689314 363855 314322 292892 81771 308267 363520 64156 291912 498003 296390 50689 25272 117281 314384 313121 287398 50522 500133 100912585 679539 315305 114509 81647 301059 81649 362418 305451 116663 100363500 309361 361765 289014 81646 103694903 309165 315139 311245 84351 114495 100910771 317546 50658 361565 300980 116596 303200 315994 100912618 681260 501560 116554 24516 362356 81722 287707 24672 309452 24673 498837 315648 117269 116725 100912032 287280 309295 81736 362491 25742 60587 305751 309957 81525 304859 54226 NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME%R-RNO-5654733.1 Negative regulation of FGFR4 signaling 116590 500985 306141 500526 83805 681260 64156 81504 50689 170700 117281 54250 25444 50522 24672 24673 314850 498837 25317 170583 29349 100912032 25114 29368 116499 25622 103694903 170582 66017 60464 HORMONE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 60%9438664 Hormone ligand-binding receptors 366668 25360 25329 171158 81668 116700 25477 25447 25653 25194 25449 GAB1 SIGNALOSOME%REACTOME DATABASE ID RELEASE 60%9438350 GAB1 signalosome 114851 366508 83571 24628 24629 315707 314641 361696 294048 64545 102552659 84482 24954 64030 50686 79240 24506 24505 294235 56718 84027 117281 24446 294515 365367 29376 59265 690919 112400 24337 24329 310131 309361 140607 81646 103694903 246273 64022 296648 64226 25267 29741 309179 29496 85243 83805 24855 361992 81745 302415 691318 25266 58918 60427 24672 24673 365865 292887 314856 309419 116590 79114 81504 170633 50689 25513 89812 170700 54250 25443 25444 170579 314850 25317 170583 29348 29349 84489 361388 25114 25022 29368 116499 25622 100363500 60662 170582 66017 25156 60464 25233 312754 24185 50557 432361 56822 25408 25660 29414 25467 360820 315648 299147 25150 59323 59325 25433 PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 60%9438045 PCNA-Dependent Long Patch Base Excision Repair 29240 59294 116468 287524 288003 361698 84490 79116 89809 296883 25737 304528 289758 288414 59102 81513 100911727 NUCLEOBASE CATABOLISM%REACTOME%R-RNO-8956319.1 Nucleobase catabolism 311580 497811 65135 287406 287368 100360582 315219 312373 171047 290365 58813 314312 361063 295620 64519 309390 64467 316077 100363253 613267 85260 289801 83585 311422 313574 361274 361068 363129 83784 116593 298881 305149 290029 117260 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 60%9438213 PP2A-mediated dephosphorylation of key metabolic factors 24672 103694903 24673 315648 171078 246255 24638 117281 ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-RNO-111446.1 Activation of BIM and translocation to mitochondria 64547 116554 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME DATABASE ID RELEASE 60%9438473 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 304349 690076 685844 689757 308995 652929 684984 54266 293618 685048 301227 301229 308417 690492 24934 305081 84349 25464 574531 25192 171369 501869 292537 680844 307199 313785 689790 501828 361289 500331 292671 365367 360647 304382 25066 287818 309684 288568 64357 103690070 25361 680910 100910725 114709 360655 361873 361673 498287 498022 24560 25713 24232 501742 498079 360777 100910669 315610 501779 501502 685157 681341 312711 683758 364049 501738 681182 303666 311144 100910801 300649 689817 474146 362445 362447 25621 298702 287813 113937 689853 362443 296562 PYRIMIDINE SALVAGE%REACTOME DATABASE ID RELEASE 60%9437908 Pyrimidine salvage 291585 100909857 304944 499956 24834 295620 311864 79127 362638 315219 291824 289801 REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME DATABASE ID RELEASE 60%9439078 Regulation of TP53 Activity through Acetylation 100910954 117535 24185 303241 361724 310511 362594 298696 84576 361374 290744 89812 84577 83712 306571 290669 297893 315713 310614 679713 362834 363292 364298 313048 114495 G2 M CHECKPOINTS%REACTOME%R-RNO-69481.1 G2 M Checkpoints 291983 289924 116468 288003 301442 289990 308669 309595 58854 360908 362304 290631 29425 301430 361815 316273 287101 64156 298534 316794 295596 500987 59102 290997 362704 308937 25203 287927 29675 50522 29671 29670 24968 25581 24967 29666 117263 117262 364814 290206 114212 161475 362817 102551184 300711 83499 290805 64046 100362315 363924 680097 306734 29614 301014 85482 689852 295277 100912489 308755 364723 361836 303353 681260 29668 304528 102548682 292766 100360950 500351 313138 296178 365388 29728 81827 287524 679983 291927 498837 307126 360621 312538 287961 313479 116725 100912032 102557184 29685 291885 288532 296883 94198 29630 296651 288414 408248 64557 100910954 100361529 64012 685055 291787 498411 313017 294800 29753 310034 25576 497672 497856 298795 315969 56011 56010 307821 25577 83806 287670 362827 85492 29669 287716 54237 29677 29672 296099 289468 300126 680537 287772 287984 311078 307511 CREB PHOSPHORYLATION%REACTOME%R-RNO-199920.1 CREB phosphorylation 314384 501560 100363500 289014 81646 315305 117269 81771 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%R-RNO-69656.1 Cyclin A:Cdk2-associated events at S phase entry 291983 24708 171150 362485 114851 83571 25729 289924 289990 58854 307821 84389 29425 64156 94201 171102 499655 83806 294790 308937 287670 29675 295052 50522 29671 29670 24968 25581 24967 29666 117263 117262 362817 161475 85492 58919 114494 83499 29614 29669 689852 303353 681260 287716 29668 292766 314642 362356 29677 29672 365388 81827 498837 266713 287772 100912032 287280 287984 366275 311078 94198 29630 296651 408248 CLASS II GLUTS%REACTOME%R-RNO-428776.1 Class II GLUTs 65197 501925 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 60%9438256 TRAF6 Mediated Induction of proinflammatory cytokines 303024 116590 25493 689314 363855 314322 81771 308267 363520 64156 291912 498003 296390 50689 25272 117281 314384 313121 287398 50522 500133 100912585 679539 315305 114509 81647 301059 81649 362418 305451 116663 100363500 309361 361765 289014 81646 103694903 309165 315139 311245 84351 114495 100910771 317546 50658 361565 300980 116596 303200 315994 100912618 681260 501560 116554 24516 362356 81722 287707 24672 309452 24673 498837 315648 117269 116725 100912032 287280 309295 81736 362491 25742 60587 305751 309957 81525 304859 54226 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 60%9439007 STING mediated induction of host immune responses 499069 498840 299827 292545 362896 293774 292892 TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 60%9438476 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 500910 360640 498206 301133 360548 311786 60371 78971 103694381 84349 171369 25008 103689974 302965 498666 362788 297604 NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME%R-RNO-112314.1 Neurotransmitter receptors and postsynaptic signal transmission 65046 83633 54223 81771 305509 24408 64508 84420 24410 24412 690825 680149 24681 245986 29241 29708 65187 29709 29707 116563 81646 24947 24703 29719 24245 24244 140675 29695 25451 29705 140724 289606 140725 29694 192258 25450 24246 24680 140729 81745 84347 29495 29422 54240 100911769 84591 308578 24611 140670 84016 59317 24242 291245 314856 29712 81637 29713 170847 25743 117052 24400 116590 116560 25686 81664 60449 81667 25643 81657 29629 29627 60355 361568 29628 25050 317203 29559 60341 54257 116649 50599 286924 315840 293621 100363500 25023 58948 83613 25252 24407 298521 553106 170945 25102 171026 25289 501560 114120 64532 25101 114118 171131 25590 293508 114119 56064 25302 65024 114117 25103 81721 54239 79557 79218 29322 24654 192213 302950 246150 117269 25400 171140 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME%R-RNO-159236.1 Transport of Mature mRNA derived from an Intron-Containing Transcript 288701 313449 689116 361814 29667 308335 690303 295284 362612 313620 361542 362687 53372 294429 315170 290519 300259 361990 299706 287113 303057 361859 292085 117021 89827 298075 304862 360845 362819 679894 305714 313308 58958 360972 245922 302729 113929 65274 689890 287830 114612 500378 79227 291797 494445 116555 362281 292007 687575 25281 683983 295692 500697 291874 308653 81738 499974 688288 296219 59087 362098 113975 501621 25497 362335 362264 298385 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%R-RNO-975110.1 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling 363520 338457 100912618 300177 679539 317468 296390 311245 684440 116725 310461 301059 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME%R-RNO-73854.1 RNA Polymerase I Promoter Clearance 171150 294693 303241 310511 84389 690966 50689 84577 308415 288651 64520 83712 502227 290669 297893 25574 362834 363017 117526 690450 680493 361420 83503 313245 301246 83582 102551184 83581 362728 361784 291703 100360868 117535 680097 295277 361724 100912489 117056 364723 103693372 680172 498109 100361574 84576 291159 100362346 102548682 304714 499766 100360950 361798 500351 679983 266713 691496 102557184 310614 306274 100912534 294236 313048 361580 PHASE 0 - RAPID DEPOLARISATION%REACTOME%R-RNO-5576892.1 Phase 0 - rapid depolarisation 29716 24245 24244 114493 140728 29658 24239 140724 140725 24246 25665 287419 140729 29686 116600 84347 306243 140726 682930 140727 312668 170630 63851 58942 170632 84488 300992 25400 24242 171140 50688 25297 DEPURINATION%REACTOME DATABASE ID RELEASE 60%9438038 Depurination 81528 24561 170841 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 60%9438192 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 295051 498272 298541 25547 83505 363103 298071 24591 302972 316033 311847 287983 502017 312826 29758 296394 114711 311530 296370 302915 29640 304860 25197 300741 297393 303692 81759 300089 291095 25280 293587 294400 303244 307848 296624 300036 360518 362031 299346 304954 407765 407764 498486 287920 301155 297417 116696 310935 501167 100911225 364901 363109 313139 362924 29204 103690047 363040 362547 311204 293129 313231 305291 81726 367083 300668 315212 360475 64442 316642 64445 304023 117185 MET RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 60%9439247 MET Receptor Activation 24446 292770 311331 29135 58947 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%R-RNO-112382.1 Formation of RNA Pol II elongation complex 303132 266787 304832 171150 289561 301119 294693 311796 25562 316123 305851 294258 287608 293184 103690054 306261 306347 364834 81785 361365 305455 303281 291705 81674 300837 84389 292778 689116 690966 366169 304758 308415 288651 502227 117017 362110 64525 81807 83503 315291 291703 298075 362479 498109 100361574 500715 308472 363633 266713 363064 100912534 294236 498453 361531 361580 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 60%9439037 Golgi Cisternae Pericentriolar Stack Reorganization 81754 116590 103690018 65158 113961 50689 56082 498266 RHO GTPASES ACTIVATE KTN1%REACTOME DATABASE ID RELEASE 60%9439161 RHO GTPases activate KTN1 314906 361029 297173 309159 363875 308875 64465 MITOCHONDRIAL ABC TRANSPORTERS%REACTOME DATABASE ID RELEASE 60%9438633 Mitochondrial ABC transporters 140669 FATTY ACID METABOLISM%REACTOME%R-RNO-8978868.1 Fatty acid metabolism 113965 24297 307092 679520 171516 65030 170670 24306 287424 24158 313375 681458 113976 313373 252898 291939 25290 679532 83842 289736 293829 170588 266604 64562 85239 100363074 100360507 65183 59103 102556347 246074 58962 499018 498962 25682 298423 117543 688517 117243 29411 84029 312086 301120 25284 84024 64304 29527 299193 499358 289014 25045 302640 26759 315173 300083 293453 296851 114097 171410 25526 361992 25527 65192 25426 307170 102549542 287454 25413 310848 171155 24157 681337 24159 50549 367808 84575 308518 359725 498728 291135 94199 171142 266674 25357 117035 24296 171400 29510 171402 79242 311849 290623 79244 56266 299732 24624 83522 83792 25756 24693 29743 25757 29740 679565 100911186 83512 54398 363516 81639 29624 100911581 100910957 85255 286904 361993 619561 296138 84013 304500 680115 503122 24653 114209 361802 291283 291076 94340 361413 25288 25287 291075 315973 29328 114024 29726 64669 289125 311865 192272 50671 170465 309449 362809 78975 29347 191576 191574 25271 503049 140547 404280 24886 50681 25363 VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME%R-RNO-5218920.1 VEGFR2 mediated vascular permeability 24244 307505 24185 81679 24600 296603 361992 81745 29432 25404 56718 299331 307618 295378 311163 100910732 29431 310131 29433 24242 246273 296648 363875 64226 25156 PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME%R-RNO-6811558.1 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling 309419 366508 116590 24628 24629 314641 294048 102552659 64545 24954 79114 64030 81504 170633 50689 25513 24506 89812 24505 294235 170700 117281 24446 54250 25443 25444 170579 365367 29376 314850 25317 170583 29348 690919 29349 84489 112400 361388 24337 25114 24329 25022 29368 116499 25622 60662 140607 170582 103694903 64022 66017 60464 25156 29741 25267 312754 309179 24185 29496 85243 83805 432361 691318 25266 56822 25408 25660 60427 24672 24673 25467 315648 365865 299147 25150 59323 59325 25433 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 60%9438581 Chemokine receptors bind chemokines 29363 29385 363682 308163 54258 100124593 298006 81503 81780 114105 60628 282832 117027 360750 29538 114492 301086 171371 685243 84475 84348 24772 171551 287673 60665 301066 246759 360918 688605 305236 245920 171056 89808 316019 362505 171054 362506 497942 246358 GLUTATHIONE CONJUGATION%REACTOME DATABASE ID RELEASE 60%9438329 Glutathione conjugation 64352 362368 100912430 29739 25458 290401 81869 103690044 309465 58962 171341 499688 114846 362196 24426 681913 297029 499689 360994 29487 289197 25283 116684 291394 78959 24422 24424 GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME%R-RNO-163841.1 Gamma carboxylation, hypusine formation and arylsulfatase activation 307404 295394 298452 287523 680594 362191 24946 303631 362409 25227 29565 306608 170818 287444 314644 288923 310261 315222 25295 24800 360800 498034 29251 81750 58935 81716 303755 54281 260320 365619 310326 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME%R-RNO-399954.1 Sema3A PAK dependent Axon repulsion 361597 246331 301252 362398 309280 100910732 29431 25150 29433 289392 29432 29751 363875 65172 299331 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME DATABASE ID RELEASE 60%9438440 VEGF binds to VEGFR leading to receptor dimerization 89811 94203 54251 114110 83785 25589 114111 360457 AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME DATABASE ID RELEASE 60%9438533 AKT-mediated inactivation of FOXO1A 84482 24185 TRNA AMINOACYLATION%REACTOME%R-RNO-379724.1 tRNA Aminoacylation 294504 310856 361842 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 60%9437846 Amino acid and derivative metabolism 291983 24957 289924 301384 363285 25274 289990 266807 58854 29425 25257 24792 300723 50719 29675 29671 29670 24513 24968 79107 24967 293949 29666 64313 117263 117262 364814 245961 361755 290206 29383 689588 161475 685325 24962 83499 114123 361215 293453 81522 29614 24314 24311 689852 29611 25014 501454 303353 24250 29668 29603 100911564 292766 170943 24401 24264 361272 365388 81827 298607 290947 85309 497840 94198 292710 29630 296651 408248 116700 305348 29301 29711 307821 641315 641316 308652 170898 289727 29700 360719 294103 29221 25721 302642 54314 29443 246281 64640 100365773 85492 365972 311446 299201 287716 309312 293589 171133 100912604 303563 79049 60356 364064 24443 316342 501620 81708 287877 291450 81718 303272 298182 25699 25698 58961 309150 100360621 25581 299735 100270683 305177 298227 24661 298934 288912 24609 117098 24616 691966 25134 84596 25120 306586 89833 300384 25611 287379 29416 25612 311844 171385 25618 59113 64206 685999 306574 24813 63864 81670 58819 66029 81676 293820 116682 25085 310152 365314 500255 680409 294972 290551 311254 63938 25331 116686 29531 361884 103691744 58835 83806 308129 304429 287670 29554 81805 364975 298942 29215 360975 315439 64203 114613 289950 300691 362428 681913 24848 287063 29593 29669 680021 29592 300035 24399 312381 246307 307759 291640 317675 29677 29672 64192 296350 81640 103690164 83784 287772 100169747 25653 287984 81654 308800 311078 79251 25502 363469 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME%R-RNO-199992.1 trans-Golgi Network Vesicle Budding 64678 317576 306332 313409 24803 81803 140673 192243 116561 83800 25751 64310 192152 252929 25319 29292 365191 100360087 367038 361459 366618 367304 304344 360785 100362805 100362547 302671 366311 29663 171575 287709 689955 683687 89816 310746 302290 81659 291464 311404 295217 288785 25387 689256 312689 360515 83730 641528 309451 680476 309969 363476 362609 312694 296199 85491 25151 25306 361632 83576 81917 294900 54241 317630 364183 100909548 116743 289312 54226 RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 60%9439327 RUNX3 regulates YAP1-mediated transcription 363014 361630 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME%R-RNO-6796648.1 TP53 Regulates Transcription of DNA Repair Genes 171150 289561 311796 294693 25562 306998 316123 305851 294258 287608 103690054 306347 364834 81785 361365 305455 362479 498109 81674 100361574 84389 500715 292778 308472 690966 304758 308415 288651 363633 502227 266713 117017 362110 64525 81807 83503 100912534 315291 294236 498453 361580 192350 291703 SIGNALING BY PTK6%REACTOME DATABASE ID RELEASE 60%9439191 Signaling by PTK6 83571 500985 25597 314596 102552659 64156 94201 312477 361617 50522 293621 296472 24697 89829 29372 690919 112400 24605 25125 24337 24329 29560 24592 64022 58919 360814 363875 24525 24185 29496 117268 363334 64015 170843 432361 681260 54245 300160 192126 113955 297173 498837 192117 25414 360820 100912032 288589 366275 309081 306400 59323 361251 296072 362271 59325 25433 304893 25676 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME DATABASE ID RELEASE 60%9438078 Glucagon signaling in metabolic regulation 24953 24400 685451 54223 60449 81667 25521 64199 25289 305509 25725 294962 114120 64532 114118 293508 64508 114119 84420 114117 25636 79218 29699 24679 100912034 302950 24952 245986 29241 TRANSPORT OF FATTY ACIDS%REACTOME DATABASE ID RELEASE 60%9438829 Transport of fatty acids 311839 65039 94106 94172 291582 680602 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME DATABASE ID RELEASE 60%9438093 Apoptotic factor-mediated response 25309 64026 25402 100363502 78963 58918 REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME DATABASE ID RELEASE 60%9439077 Regulation of TP53 Activity through Association with Co-factors 362675 171355 100910954 24185 685474 686781 246334 314465 311575 305025 292064 CELL CYCLE%REACTOME DATABASE ID RELEASE 60%9437771 Cell Cycle 289924 299331 691979 680014 303353 360161 365388 94198 314856 81754 299557 304798 114483 100910954 317425 116590 85242 301323 246327 301965 94201 307641 116549 50689 54238 25164 301701 298594 304813 286993 308443 100911204 362548 681050 317252 25023 684439 294712 304951 304477 56082 246294 298850 362504 501706 29167 287598 363028 363174 691493 289150 305270 83572 361416 116659 315164 295661 299850 291441 681185 25448 316425 296137 257649 257644 117103 116670 29648 366275 498310 114514 311327 306464 303037 307511 24708 362485 114851 83571 25729 304740 114482 308064 305467 683722 252921 308669 309595 360860 290631 361815 287101 316794 500987 499933 171102 499655 294790 290997 362704 308937 25203 24679 304218 314949 25581 63996 290577 29486 305343 313304 315958 290668 290805 64046 100362315 363924 306734 301014 85482 308755 361836 100362333 299112 680006 304573 399489 100909750 311562 682033 291105 117104 311860 81758 684111 83806 287670 500545 114592 362965 293733 81650 362827 64041 65201 690237 29669 362044 361403 171529 287624 362763 25255 64465 292787 305171 500054 85265 689523 307861 306102 297758 307798 314642 58921 29677 290232 29672 296099 289468 300126 680537 685474 287772 291137 292071 287984 311078 84391 362186 315740 291983 24514 289990 58854 29425 117281 365155 29675 295052 29671 29670 24968 24967 29666 117263 117262 364814 290206 103694903 114212 362817 161475 300711 311575 114494 83499 309179 29614 689852 29668 292766 691318 307639 499914 24672 81827 24673 297176 296368 360643 498030 290842 292058 305420 293155 29630 296651 408248 362980 64557 692032 306594 307169 100361529 300149 64012 361308 685055 103690018 291787 362798 498411 60336 294800 113961 287447 310034 29214 60334 497672 291914 310511 497856 315969 100360828 498266 307821 171103 361643 361613 29380 406168 362203 287929 306599 308663 308870 309098 301252 85492 680991 691918 361634 680477 312754 305909 24185 305882 29479 64462 293844 100911033 300963 363055 311546 81740 315423 367153 24669 500069 291540 294010 25594 287716 690209 311191 192228 64158 316531 309692 296554 100362495 311529 305288 311802 311573 313977 286919 360672 299730 58822 310344 83836 103690034 261730 290626 305002 246150 114764 315648 311886 29213 299147 60347 313048 303024 171150 116468 288003 301442 302661 292263 310806 360908 362304 25737 84389 301430 316273 64156 298534 295596 289758 316602 59102 287927 300947 689399 50522 681382 307766 83712 689296 680111 297893 89809 689820 100360427 58919 361178 102551184 116651 53372 81513 294429 300259 299706 680097 292085 117021 304862 295277 84490 100912489 364723 58958 245922 83805 113929 24680 65274 85252 681260 287830 304528 84576 102548682 116555 362281 25281 100360950 683983 295692 500351 291874 81738 59294 499974 313138 296178 300084 287524 29728 679983 291927 113975 307126 498837 360621 266713 361698 312538 287961 116725 313479 102557184 100912032 29685 25497 291885 362335 288532 65137 296883 288414 84593 100911727 171576 290875 361389 64515 296558 313017 29753 291689 366381 25576 311412 298795 100360936 361831 56011 56010 304490 361662 100359528 25577 65158 678726 361765 25437 114087 60374 361907 362779 315330 64193 684771 295107 362356 362519 305392 54237 363481 81515 287280 170845 307805 360886 297522 363059 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME%R-RNO-69601.1 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 291983 289924 29614 29669 689852 289990 303353 58854 681260 307821 287716 29425 29668 64156 292766 171102 83806 29677 287670 29675 29672 50522 365388 29671 81827 29670 498837 24968 25581 24967 287772 100912032 29666 287984 117263 311078 117262 364814 94198 290206 29630 114212 296651 161475 408248 85492 83499 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME DATABASE ID RELEASE 60%9438786 Activation of Ca-permeable Kainate Receptor 24244 25252 24242 29559 54257 29495 24407 298521 58948 553106 PI METABOLISM%REACTOME%R-RNO-1483255.1 PI Metabolism 309419 366508 317576 305935 84018 306490 314641 310155 312634 80849 114554 305419 25513 114561 89812 85238 315673 361659 367786 498331 309855 309008 282584 298947 140607 64310 360521 287607 364298 116699 289021 116482 29741 295674 25532 85243 308584 317296 54259 500132 50557 65052 305482 116720 171088 316457 363131 315422 81747 306460 365865 307842 360753 497931 94197 497932 361632 300147 364629 114089 60664 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 60%9438967 Degradation of cysteine and homocysteine 691966 81805 60356 292710 25274 24962 103691744 170943 81718 MET ACTIVATES STAT3%REACTOME%R-RNO-8875791.1 MET activates STAT3 24446 25125 PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME%R-RNO-211945.1 Phase I - Functionalization of compounds 24297 24298 501620 24306 24294 313375 313373 25243 25242 353498 154985 304078 25256 25690 500892 57300 362782 25642 298423 310903 171118 291084 65029 361631 679817 266761 29646 83724 690745 312495 25429 100145871 685645 25527 25426 25428 25427 310848 100910481 252931 100361492 313786 50549 367808 498940 100910462 498999 171178 266674 499353 24296 361239 24664 25147 103691072 25315 24303 24307 24300 24172 25086 290623 29295 25750 297081 56266 308652 25035 286963 100365112 24693 81924 29253 29539 100910877 29441 25375 298079 301252 29473 685222 100910127 308190 29189 291952 246245 296259 292728 100910144 312317 310201 311569 286904 54246 114700 313929 25053 312316 286953 299566 503122 171451 293589 308445 171352 171522 361523 301264 79122 362809 25279 25271 80773 282827 60351 24886 192257 266684 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-RNO-1296059.1 G protein gated Potassium channels 29712 29713 170847 25743 690825 24400 117052 83633 116560 680149 60449 81667 81657 245986 114120 116649 50599 114118 114119 114117 29719 79218 CLEARANCE OF SERATONIN%REACTOME%R-RNO-380615.1 Clearance of seratonin 25553 29253 29539 AGMATINE BIOSYNTHESIS%REACTOME%R-RNO-351143.1 Agmatine biosynthesis 298607 PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME DATABASE ID RELEASE 60%9439207 Processing of DNA double-strand break ends 290805 64557 64046 100362315 363924 100361529 64012 116468 306734 685055 301014 291787 85482 288003 498411 294800 310034 497672 497856 308755 315969 361836 304528 59102 299638 295052 287524 297486 171366 296883 288414 362817 300711 114494 CLEC7A INFLAMMASOME PATHWAY%REACTOME DATABASE ID RELEASE 60%9439192 CLEC7A inflammasome pathway 24494 64044 282817 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME DATABASE ID RELEASE 60%9438519 Vitamin D (calciferol) metabolism 24384 25279 63865 361631 80848 114700 RAB GERANYLGERANYLATION%REACTOME%R-RNO-8873719.1 RAB geranylgeranylation 81754 79434 81756 85237 25531 117103 252916 25533 58983 81830 24942 65158 102555167 100363782 100126191 FRS-MEDIATED FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 60%9439179 FRS-mediated FGFR3 signaling 79114 81504 170633 170700 313845 54250 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 25114 25022 29368 116499 25622 60662 170582 24525 66017 60464 PAOS OXIDISE POLYAMINES TO AMINES%REACTOME DATABASE ID RELEASE 60%9438138 PAOs oxidise polyamines to amines 501620 308652 293589 PI3K CASCADE%REACTOME%R-RNO-109704.1 PI3K Cascade 26954 362045 301574 56011 79114 81504 64562 170633 287871 25513 170700 56718 100912571 54250 301518 25443 25444 116636 298514 170579 29376 314850 25317 170583 29348 29349 84489 361388 25114 25022 29368 116499 25622 60662 170582 246273 308869 60445 66017 64226 60464 25233 300253 290291 338457 29741 83803 24185 29516 295234 65248 85243 360776 24855 65052 361992 81745 303605 363131 310091 100361543 501146 83840 25467 295357 117045 78975 292887 100909655 117044 117043 297960 25435 RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME%R-RNO-8876198.1 RAB GEFs exchange GTP for GDP on RABs 81754 29753 50993 307039 311880 363858 680465 25183 29448 50645 287427 100909916 312257 306229 691042 290746 103689930 114638 252916 94193 361987 311494 501550 299799 292074 315999 309678 360797 171452 315756 304555 315055 84379 314013 365042 316017 25530 207119 308942 291750 363235 289350 311913 314397 289051 294709 288700 24185 362983 308944 360768 84589 100911794 360827 24942 313493 309306 315668 81756 100910318 299075 25531 94197 300147 29662 362599 REGULATION OF RAS BY GAPS%REACTOME DATABASE ID RELEASE 60%9439187 Regulation of RAS by GAPs 291983 289924 289990 25597 314596 58854 307821 29425 83806 287670 29675 29671 293621 29670 24968 25581 24967 29372 24605 29666 117263 117262 364814 290206 24592 161475 85492 360814 24525 83499 29614 29669 689852 303353 287716 29668 292766 29677 192126 29672 365388 81827 192117 287772 287984 288589 311078 94198 296072 29630 296651 408248 304893 25676 PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME%R-RNO-112308.1 Presynaptic depolarization and calcium channel opening 54234 116600 84347 257648 50688 140725 58942 25297 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-RNO-450341.1 Activation of the AP-1 family of transcription factors 81649 116590 50658 689314 116554 24516 50689 25272 314322 81647 TRKA ACTIVATION BY NGF%REACTOME DATABASE ID RELEASE 60%9438226 TRKA activation by NGF 24225 81737 25730 310738 29613 25054 59109 DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 60%9438030 Developmental Biology 289924 305104 306628 84482 306871 361364 299331 362513 60630 292139 25454 29423 497815 294515 114523 54319 286908 83510 65218 299737 498898 361537 502694 29148 337868 499497 361432 25714 299766 300811 360600 308875 313644 295234 303353 362285 304822 365388 290905 94198 362584 361319 100911681 302934 299587 24332 307562 116590 100910851 498087 60335 291755 408215 291752 295190 292949 303687 100910942 295625 310575 292848 304883 360891 360272 100911797 288067 291760 58946 408235 408214 307641 312477 116549 50689 307563 288075 83785 25589 293619 79208 60583 316539 291754 29210 366492 689230 308564 24884 308562 100362978 308565 684969 298528 310643 312279 84358 94268 171287 60589 100909840 171574 81531 79115 287876 65172 25271 309081 306400 54227 100361457 288669 65046 682507 314641 116690 29686 245956 50687 306570 29491 25664 25581 64303 116563 83800 140694 25751 81732 25418 116671 84357 361597 246217 25416 25417 25415 65208 361549 360638 78966 24923 84009 140724 140725 64373 140729 296603 304109 306013 252892 114559 84347 60352 301460 300955 366957 64159 310192 83841 316009 308578 361517 140670 297518 54241 140908 116743 81637 362045 100909750 301227 311860 81687 83806 287670 289231 81650 81649 300054 293674 307505 246331 362398 309280 29669 81679 64465 289820 83630 29458 60329 366214 81762 29677 29672 297173 287772 287984 311078 84393 266729 24718 310695 25696 289392 316639 362993 29751 306790 291983 450228 501725 300242 171109 501721 24514 246145 363678 246144 100361739 366991 24628 24629 680060 293847 100363287 313874 303530 25453 287679 289990 287678 25597 450229 314596 287675 29434 450227 364686 100359826 690431 116562 407762 58854 303528 102552659 170668 303527 363739 29425 497995 65179 407759 24408 25167 450225 689927 64030 360626 407761 360623 24716 100363136 24410 407760 24412 303523 684589 117281 24446 406227 266717 100361702 498576 29675 406226 100361571 29671 407757 29670 680396 29376 287697 24968 683613 24967 501720 29372 690478 303519 690919 25704 681126 112400 294853 29666 100365646 24337 501765 24329 687631 117263 287702 117262 100363184 116663 287700 102552748 364814 680328 290206 24592 100361664 683212 103694903 680071 64022 100364550 161475 300248 300247 360814 287701 24703 690460 288297 83499 100910814 83501 24245 24244 25267 309179 29614 29496 29211 58920 689852 64363 24497 652957 116630 140924 114103 24246 289257 84423 84422 29668 29495 25614 100364613 292766 691318 25266 407758 100359886 287699 362572 287698 360573 60427 24672 309168 81827 24673 288924 171081 24242 291245 296072 29630 81511 296651 408248 304893 24586 25746 360854 361568 307821 29432 301252 25615 58982 100910732 85492 363875 116696 83613 313494 312754 24185 300980 66023 25525 25326 314612 29302 305203 685269 312664 25136 432361 287716 114858 58960 192126 29542 192213 25467 192117 364052 246150 315648 305614 299147 288589 25400 25150 59323 25344 171140 84598 170577 59325 25433 25676 310533 366508 50938 116470 689314 360715 64156 29357 50522 81822 100912585 114509 25631 85420 81646 290361 89807 89804 84427 85243 83805 24680 681260 25311 25537 498837 295378 306636 296789 25186 361882 100912032 24338 315711 501203 363517 313498 287989 29431 312652 310207 29433 311384 316369 100911293 360546 300802 691658 81751 365872 292788 56011 84477 79114 81504 170633 25513 140941 170700 313845 314384 54250 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 361388 25114 25738 25022 29368 116499 25622 100363500 60662 85385 170582 140593 24525 66017 60464 498416 81515 81686 25626 315323 450230 315318 25744 500562 309957 294562 103694398 315320 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 60%9438246 Signalling to RAS 291983 171109 24514 246145 289924 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 58854 102552659 170668 29425 65179 24408 25167 64030 59109 24716 24410 24412 117281 24446 498576 29675 29671 29670 29376 24968 24967 29372 690919 25704 112400 29666 24337 24329 117263 117262 116663 364814 290206 24592 103694903 64022 161475 360814 24703 83499 24245 24244 25267 309179 29614 29496 295234 29211 689852 64363 24497 652957 116630 140924 114103 24246 303353 289257 84423 84422 29668 29495 25614 292766 691318 25266 362572 360573 60427 24672 309168 365388 81827 24673 288924 171081 24242 94198 291245 296072 29630 81511 296651 408248 304893 24586 25746 116590 307821 50689 85492 83613 312754 300980 66023 25525 25326 314612 305203 312664 25136 432361 287716 114858 58960 192126 29542 192213 25467 192117 364052 246150 315648 305614 299147 81757 288589 25400 25150 59323 25344 29622 171140 84598 29613 170577 25054 116546 59325 25433 25676 310533 689314 64156 50522 25581 289014 89807 310738 89804 83805 681260 64159 498837 100912032 362045 56011 79114 81504 170633 83806 170700 313845 54250 287670 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 25114 25022 81649 29368 116499 60662 85385 170582 24525 66017 60464 29669 315994 24225 81737 25730 29677 29672 287772 287984 311078 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%R-RNO-549132.1 Organic cation anion zwitterion transport 29503 29504 29726 29509 89776 50662 24904 365398 POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 60%9439167 POLB-Dependent Long Patch Base Excision Repair 29240 362600 83507 84490 25591 81513 79116 100911727 PKMTS METHYLATE HISTONE LYSINES%REACTOME DATABASE ID RELEASE 60%9439115 PKMTs methylate histone lysines 500351 291844 689883 680097 679983 309452 295277 100912489 308345 102557184 364723 689820 312800 309165 102548682 81736 361688 102551184 100360950 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 60%9438662 Chaperonin-mediated protein folding 299809 24400 288620 50664 297406 25686 81664 60449 81667 25643 295230 24818 690155 365901 363143 25740 29481 294864 29374 294962 83579 64013 307641 116549 54296 286924 81650 288305 MET ACTIVATES RAS SIGNALING%REACTOME%R-RNO-8851805.1 MET activates RAS signaling 313845 24446 293621 85385 81504 303886 24525 24605 361396 364686 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME DATABASE ID RELEASE 60%9438315 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase 290875 361389 64515 296558 296368 291689 360643 366381 498030 311412 100360936 361831 310806 305420 304490 293155 314642 MAP2K AND MAPK ACTIVATION%REACTOME%R-RNO-5674135.1 MAP2K and MAPK activation 360573 58960 498576 246145 29542 362045 116590 293621 295234 24605 56011 288924 170577 50689 24525 24703 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%R-RNO-3065679.1 SUMO is proteolytically processed 303874 103689978 301442 78973 499417 300193 679900 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-RNO-176814.1 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins 291983 171576 290875 361389 64515 289924 296558 291689 366381 114482 289990 311412 100360936 361831 304490 361662 58854 307821 29425 64156 83806 25203 287670 29675 295052 50522 29671 29670 24968 24967 25581 29666 117263 117262 364814 290206 161475 85492 114494 83499 29614 29669 689852 64193 303353 681260 690209 287716 29668 292766 54237 29677 29672 365388 81827 498837 297176 296368 360643 287772 498030 100912032 305420 293155 287984 311078 94198 29630 296651 408248 CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 60%9437924 Caspase activation via extrinsic apoptotic signalling pathway 266610 246775 25385 246097 25402 117279 311786 246756 306886 25311 290537 64044 58918 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 60%9438410 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 307092 171516 79111 83724 313929 25284 79244 252898 191574 83569 25271 170588 291283 29725 60351 65192 192242 81924 25428 246211 BLOCH PATHWAY%REACTOME DATABASE ID RELEASE 60%9438446 Bloch pathway 117278 64191 298298 114100 COSTIMULATION BY THE CD28 FAMILY%REACTOME DATABASE ID RELEASE 60%9438456 Costimulation by the CD28 family 315707 25710 64545 116689 81504 29432 25513 56718 117281 360640 301626 100910732 309304 310131 25622 103694903 246273 296648 24884 363875 300678 64226 25156 309621 499342 312754 309179 25300 24185 315609 24932 309622 116596 64465 83805 294269 361992 81745 407756 688090 691318 56822 24981 294270 25408 25660 81515 24672 24673 315648 299147 63835 29431 29433 103689997 25150 310695 366518 499415 DOWNREGULATION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 60%9438932 Downregulation of ERBB2 signaling 50522 24185 29496 498837 60450 690919 301333 362814 100912032 112400 24337 287155 24329 102552659 432361 681260 117255 64156 59323 64022 59325 25433 296121 299331 RESPIRATORY ELECTRON TRANSPORT%REACTOME%R-RNO-611105.1 Respiratory electron transport 362897 293114 100363268 296190 293448 297990 100912599 81728 299643 303922 299310 7066248 497902 301458 7066247 301427 499529 362344 362495 316632 295143 315167 362810 291660 29478 684509 293130 288088 361385 26194 295923 26199 301123 679739 25488 26192 26193 292845 301011 299739 678759 299008 293991 56769 64539 293453 26201 300447 299954 25309 300726 7066259 293652 296086 7066258 7066257 26203 7066256 300047 26202 100363502 7066254 680288 293655 366448 294973 298748 300091 294964 289218 363441 100911483 681418 690848 362837 362440 362588 291103 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%R-RNO-1475029.1 Reversible hydration of carbon dioxide 54233 313495 791259 54232 363085 291819 499566 302669 54231 310218 298657 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%R-RNO-174084.1 Autodegradation of Cdh1 by Cdh1:APC C 291983 290875 361389 289924 296558 291689 366381 289990 311412 100360936 361831 304490 58854 307821 29425 64156 83806 287670 29675 50522 29671 29670 24968 25581 24967 29666 117263 117262 161475 85492 83499 29614 29669 689852 303353 681260 287716 29668 292766 314642 29677 29672 365388 81827 498837 296368 360643 498030 287772 100912032 305420 293155 287984 311078 94198 29630 296651 408248 SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME%R-RNO-5693548.1 Sensing of DNA Double Strand Breaks 64046 64012 85482 85245 300711 100359600 ACTIVATION OF SMO%REACTOME DATABASE ID RELEASE 60%9439165 Activation of SMO 683470 289711 29499 50938 25238 113927 289712 89830 25387 360715 361438 362549 84392 25388 25273 304318 FCERI MEDIATED MAPK ACTIVATION%REACTOME%R-RNO-2871796.1 FCERI mediated MAPK activation 291983 171109 24514 246145 289924 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 58854 102552659 170668 29425 65179 24408 25167 64030 24716 24410 24412 117281 24446 498576 29675 29671 29670 29376 24968 24967 29372 690919 25704 112400 29666 24337 24329 117263 117262 116663 364814 290206 24592 103694903 64022 161475 360814 24703 83499 24245 24244 25267 309179 29614 29496 295234 29211 689852 64363 24497 652957 116630 140924 114103 24246 303353 289257 84423 84422 29668 29495 25614 292766 691318 25266 362572 360573 60427 24672 309168 365388 81827 24673 288924 171081 24242 94198 291245 296072 29630 81511 296651 408248 304893 24586 25746 116590 307821 29432 50689 100910732 85492 363875 83613 312754 300980 66023 25525 25326 314612 305203 312664 25136 432361 287716 114858 58960 192126 29542 192213 25467 192117 364052 246150 315648 305614 299147 288589 25400 25150 59323 25344 171140 84598 170577 59325 25433 25676 310533 363855 314322 64156 25272 50522 287398 25581 89807 89804 83805 296603 681260 64159 155918 498837 295378 100912032 29431 362045 56011 79114 81504 170633 83806 170700 313845 54250 287670 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 25114 25738 25022 29368 116499 60662 85385 170582 25155 24525 66017 25156 60464 50658 29669 100912399 116667 116554 24516 29677 29672 81515 287772 287984 311078 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 60%9438047 SLBP independent Processing of Histone Pre-mRNAs 171365 681031 687711 100360682 689116 501688 687679 298075 366468 680737 292884 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%R-RNO-1650814.1 Collagen biosynthesis and modifying enzymes 289081 25506 84032 305104 306628 25412 312115 60379 29393 300901 287899 678743 360526 305253 294279 116552 353303 304021 288583 298101 29569 85250 361612 102555086 313592 362285 83470 315071 309837 294027 301012 363457 363158 84352 85251 25654 366474 85490 290905 103689932 64475 367236 29345 685612 290637 499431 311716 362584 64367 314981 INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-RNO-6783589.1 Interleukin-6 family signaling 29201 24514 310132 500985 365395 25124 81680 89829 245983 25125 289747 313173 25707 25622 84598 367264 290655 25205 24498 171040 60584 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 60%9438301 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription 304758 300947 29357 50522 680111 498837 300813 29417 362110 100912032 681260 84396 25631 64156 315291 500715 500695 100360427 24790 361178 295062 116651 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 60%9438142 Mitotic Spindle Checkpoint 171576 290875 361389 64515 680006 297176 296558 296368 291689 360643 366381 498030 311412 100360936 361831 305420 304490 361662 293155 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%R-RNO-193692.1 Regulated proteolysis of p75NTR 24596 100911293 300802 691658 81751 57027 309165 365872 311245 81736 292788 289231 RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME DATABASE ID RELEASE 60%9439317 RUNX3 regulates CDKN1A transcription 59086 25631 100910954 307829 CREB3 FACTORS ACTIVATE GENES%REACTOME DATABASE ID RELEASE 60%9439310 CREB3 factors activate genes 303016 302705 314638 298400 89842 RECEPTOR MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 60%9439322 Receptor Mediated Mitophagy 360827 363442 288731 307641 64862 116549 81650 361321 362245 83805 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%R-RNO-2022377.1 Metabolism of Angiotensinogen to Angiotensins 24310 290963 290257 24715 24590 54242 25627 24179 252929 302526 498012 BETA DEFENSINS%REACTOME%R-RNO-1461957.1 Beta defensins 305354 117029 641627 83687 308163 310553 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 60%9438426 p75 NTR receptor-mediated signalling 64547 25402 25493 29753 64639 363520 113894 64156 29491 313845 50522 24596 83765 315691 362548 57027 450224 29409 360678 297893 170820 289231 301059 362418 309165 311245 84351 363875 25156 310738 246217 140898 64314 310460 361223 78966 84009 310635 84006 361921 303634 24225 363509 81737 307098 296603 681260 25730 304109 687105 117089 114559 117020 84469 293024 116554 100362710 292750 363460 310192 85384 301334 310999 362648 304193 297173 290541 311647 498837 309653 295378 84578 100912032 100911293 300802 691658 81751 365872 81736 362491 292788 83537 REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME%R-RNO-6804756.1 Regulation of TP53 Activity through Phosphorylation 314856 64557 116550 304798 288533 100910954 100361529 116468 291773 64012 682902 294018 305851 685055 288003 291787 689314 498411 293345 310784 294800 171152 310034 100360100 497672 81785 497856 315969 64156 307641 64562 313777 116549 307485 59102 170844 301518 295052 50522 362342 114592 299694 297822 81650 365895 81649 117526 114212 362817 58936 300711 114494 290805 64046 116671 100362315 363924 83803 306734 301014 85482 65248 311546 308755 361836 298696 681260 685619 304528 362272 287524 314862 498837 261730 100912032 78975 296883 498183 288414 140908 CYTOSOLIC TRNA AMINOACYLATION%REACTOME%R-RNO-379716.1 Cytosolic tRNA aminoacylation 294504 361842 APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME DATABASE ID RELEASE 60%9438318 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 291983 171576 290875 361389 64515 289924 296558 291689 366381 114482 289990 311412 100360936 361831 304490 361662 58854 307821 29425 64156 83806 287670 29675 295052 50522 29671 29670 24968 24967 25581 29666 117263 117262 364814 290206 161475 85492 114494 83499 29614 29669 689852 303353 681260 690209 287716 29668 292766 54237 29677 29672 365388 81827 498837 297176 296368 360643 287772 498030 100912032 305420 293155 287984 311078 94198 29630 296651 408248 PDE3B SIGNALLING%REACTOME DATABASE ID RELEASE 60%9438186 PDE3B signalling 29516 SIGNALING BY VEGF%REACTOME%R-RNO-194138.1 Signaling by VEGF 89811 291983 171109 24514 246145 289924 246144 24628 24629 293847 313874 25453 289990 25597 314596 114111 29434 360457 364686 116562 58854 102552659 170668 29425 65179 24408 25167 64030 24716 24410 24412 56718 362513 117281 299331 24446 498576 29675 29671 29670 29376 24968 24967 29372 690919 25704 112400 29666 24337 24329 117263 310131 117262 116663 170538 364814 290206 24592 103694903 246273 64022 161475 296648 360814 24703 64226 83499 24245 24244 25267 309179 29614 29496 29211 295234 689852 64363 24497 652957 116630 140924 114103 24246 303353 289257 84423 361992 84422 29668 81745 29495 25614 292766 691318 25266 362572 360573 60427 24672 309168 365388 81827 24673 288924 171081 24242 291245 94198 296072 29630 81511 296651 408248 304893 24586 25746 308666 116590 307821 29432 50689 81678 500904 100910732 83785 25023 25589 85492 363875 83613 312754 58823 24185 300980 66023 25525 25326 29302 314612 305203 312664 25136 432361 287716 313024 25404 114858 58960 307618 192126 29542 679934 192213 79249 25467 192117 364052 25414 246150 360820 315648 303073 311163 305614 299147 288589 25400 25150 309081 59323 361251 25344 362271 171140 84598 117542 170577 59325 114553 25433 25676 310533 689314 64156 50522 25581 289014 89807 29741 89804 85243 24600 83805 171119 24680 29513 296603 681260 60352 300955 64159 25522 25537 498837 295378 24471 100912032 29431 29433 316369 315348 362045 66021 56011 79114 81504 170633 25513 83806 170700 313845 287670 54250 25443 25444 81527 170579 310688 316213 308444 293621 314850 25317 170583 29348 29349 84489 24605 25114 25738 81649 25022 29368 116499 60662 85385 170582 24525 66017 25156 60464 307505 246331 25679 25262 29669 81679 64465 315994 94203 54251 114110 54245 81762 29677 29672 297173 287772 50646 79129 287984 311078 STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME DATABASE ID RELEASE 60%9439082 STAT6-mediated induction of chemokines 498840 299827 362896 GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 60%9439264 Golgi-to-ER retrograde transport 81754 304978 84599 252902 361577 60355 307039 500251 246310 310710 362162 360611 140673 315345 503165 297428 64189 290659 84379 100126191 360426 289350 362504 29167 114113 362044 294324 81655 309159 362466 171529 29564 287624 83572 290798 84428 314473 171304 116659 315131 140734 308961 292090 140932 24653 304290 360953 299850 690073 79214 290627 65165 300674 114023 361207 300888 84392 314906 309451 84393 289168 296284 84391 362186 293502 102555167 85248 79120 315298 315740 363059 100363782 AQUAPORIN-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 60%9438082 Aquaporin-mediated transport 25108 24400 685451 54223 60449 81667 25521 64199 25289 81830 305509 25725 294962 114120 64532 83579 114118 64508 293508 114119 84420 114117 25636 79218 29699 65054 29171 24679 308003 25132 690825 25293 100912034 680149 302950 29170 25480 245986 25241 29241 25240 24221 SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME%R-RNO-2142696.1 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) 287454 INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 60%9438164 Intrinsic Pathway of Fibrin Clot Formation 691992 65051 116669 100911551 24903 116727 29681 502858 24946 25259 79224 100911545 295703 29251 290757 306761 293118 304917 25048 24153 302470 29366 288001 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-RNO-69613.1 p53-Independent G1 S DNA damage checkpoint 291983 289924 29614 29669 689852 289990 303353 58854 681260 307821 287716 29425 29668 64156 292766 171102 83806 29677 287670 29675 29672 50522 365388 29671 81827 29670 498837 24968 25581 24967 287772 100912032 29666 287984 117263 311078 117262 364814 94198 290206 29630 114212 296651 161475 408248 85492 83499 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-RNO-68962.1 Activation of the pre-replicative complex 100362333 299112 304573 85242 301323 246327 360908 362304 301430 316273 295596 59102 313138 296178 287524 29728 291927 307126 360621 312538 287961 313479 29685 292071 291885 288532 296883 362817 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME DATABASE ID RELEASE 60%9438270 DEx H-box helicases activate type I IFN and inflammatory cytokines production 81722 309452 309165 81736 25742 304859 310461 54226 301059 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 60%9438732 Deadenylation of mRNA 308311 100912571 300253 306492 295707 688288 363603 408200 291841 117045 291615 365684 287436 360917 299805 312227 501515 363221 301513 303831 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%R-RNO-1592389.1 Activation of Matrix Metalloproteinases 85253 102554637 408247 299606 29268 25697 63849 683849 29543 81687 24691 25481 171052 81707 103690254 117061 25052 306404 85251 290257 25627 25335 300339 81686 24291 29175 54281 25048 362347 54271 116510 65205 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%R-RNO-113501.1 Inhibition of replication initiation of damaged DNA by RB1 E2F1 24708 24672 103694903 24673 85242 301323 682033 315648 246327 117281 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 60%9438481 Synthesis of PIPs at the plasma membrane 309419 295674 366508 29741 317576 305935 25532 85243 84018 308584 317296 54259 500132 314641 50557 305482 312634 80849 116720 114554 305419 171088 25513 89812 85238 361659 367786 498331 365865 282584 298947 497931 140607 497932 94197 361632 64310 360521 116699 289021 60664 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 60%9437790 Lagging Strand Synthesis 59294 116468 287524 288003 361698 85242 84490 301323 246327 89809 361836 296883 25737 304528 289758 288414 59102 81513 100911727 SULFUR AMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 60%9438331 Sulfur amino acid metabolism 305177 298227 81805 81522 298934 288912 25274 290947 81718 29443 24250 691966 292710 60356 25331 365972 24962 103691744 170943 INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME DATABASE ID RELEASE 60%9439265 Intra-Golgi and retrograde Golgi-to-ER traffic 252902 246310 314393 24197 64189 64310 192152 311919 287535 117051 84589 500249 364981 116500 501069 309922 25218 286932 64187 293344 100361513 296649 291309 690407 367308 313493 500906 309306 60562 116691 310526 116693 116692 116639 315668 299258 308821 310411 365793 300674 361407 361207 361073 312689 364033 300888 29528 309451 303652 25151 293456 100359675 102555167 291990 100909548 79120 100363782 81754 304978 84599 65134 361577 60355 307039 500251 310710 64154 690961 362162 64516 64351 360611 140673 315345 503165 94189 297428 290659 84379 100126191 360426 289350 362504 29167 114113 362044 294324 309159 81655 362466 171529 287624 29564 83572 290798 314473 84428 171304 116659 315131 140734 308961 140932 292090 304290 24653 360953 299850 690073 79214 290627 316130 65165 114023 84392 314906 84393 289168 296284 84391 362186 293502 85248 315298 315740 363059 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%R-RNO-2142816.1 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 56266 24297 286904 503122 310848 24306 266674 298423 290623 50549 25426 24296 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 60%9438653 Striated Muscle Contraction 292879 500450 117557 688228 24852 81818 24851 25566 29248 24585 171409 64362 29388 291245 29389 56781 24838 24837 171009 290561 296369 24583 295929 24907 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME DATABASE ID RELEASE 60%9438427 p75NTR recruits signalling complexes 310738 50522 24596 498837 84006 100912032 301059 362418 681260 363520 64156 113894 311245 362491 84351 LDL CLEARANCE%REACTOME%R-RNO-8964038.1 LDL clearance 298296 81637 308578 54225 266732 65046 25055 81782 300438 266770 140670 294930 116563 83800 54241 500564 ENOS ACTIVATION%REACTOME%R-RNO-203615.1 eNOS activation 298184 24244 64157 24242 25514 24185 294239 24600 25404 170520 299331 EGFR TRANSACTIVATION BY GASTRIN%REACTOME DATABASE ID RELEASE 60%9438684 EGFR Transactivation by Gastrin 24329 313845 24680 293621 81504 25433 24525 24605 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%R-RNO-445989.1 TAK1 activates NFkB by phosphorylation and activation of IKKs complex 100910771 317546 25493 308267 100912618 363520 291912 296390 81722 287707 313121 500133 309452 679539 116725 301059 362418 309295 309361 309165 315139 362491 311245 81736 84351 25742 305751 81525 54226 304859 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%R-RNO-1250347.1 SHC1 events in ERBB4 signaling 313845 59323 293621 85385 64022 81504 690919 59325 25433 24525 112400 24605 NGF-INDEPENDANT TRKA ACTIVATION%REACTOME DATABASE ID RELEASE 60%9438370 NGF-independant TRKA activation 25369 29613 25054 59109 24166 STEROL TRANSPORT%REACTOME%R-RNO-8963749.1 Sterol transport 155192 114628 BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME%R-RNO-77352.1 Beta oxidation of butanoyl-CoA to acetyl-CoA 64304 113965 100911186 140547 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME%R-RNO-373076.1 Class A 1 (Rhodopsin-like receptors) 192649 64636 192648 171101 25360 308163 25369 171108 100124593 691774 25447 25449 65032 29238 50577 25111 29581 292661 29597 25380 29595 117027 25726 192646 25723 24889 25370 408199 360750 24938 292794 171371 360579 54305 25075 29234 301066 497196 29237 25461 378939 171104 24929 25107 25477 287910 25593 290493 299242 25432 25194 25007 117264 64803 681706 500157 171158 25329 299757 259222 259224 64042 25187 114492 25229 366668 690158 84475 24903 84348 29256 24772 24473 81638 366274 29462 366270 170704 25706 310327 25033 116700 29471 24664 379044 25354 25555 362454 308408 59264 24808 24677 29290 24806 24807 81644 690198 25516 25570 24604 25569 171044 170926 297795 171054 83518 81668 497942 246358 25195 25504 24613 25635 25637 81509 363682 100360071 29180 282839 103694905 81780 50672 282832 24260 114215 289023 29191 266997 114211 301086 679975 685243 266607 25323 25324 63850 288995 58812 117549 362119 367315 360918 688605 66024 114098 60669 114099 246075 171056 679957 89808 353250 316019 292310 314386 94204 497078 63887 63889 309212 103690156 24448 252939 25340 297025 408243 24659 302619 25342 53949 29385 84007 25616 498475 689936 29538 338443 287730 690230 287673 292413 292419 60337 192223 292409 25605 63843 24176 89810 25108 60448 54258 314649 500317 24316 60399 66025 365228 192206 306792 24318 192205 113959 60628 24323 24324 24326 288001 25601 24816 29316 171551 29413 29412 60665 29310 24180 24182 100363178 29190 24179 81645 81752 54226 310444 78964 100909783 59301 445269 302378 81503 295144 294807 25524 25645 29141 102553138 116498 100911796 29251 25439 29636 305236 25689 24221 362505 295401 116744 362506 498609 29733 29415 29363 25298 298006 25265 24175 501177 114105 24232 25083 116677 767613 84022 499194 57302 57305 317219 29335 363866 64107 85268 24797 246759 58949 25652 25653 100909648 314480 245920 29358 64354 25248 25245 NEUROPHILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME%R-RNO-194306.1 Neurophilin interactions with VEGF and VEGFR 81527 54251 246331 25589 MAPK6 MAPK4 SIGNALING%REACTOME DATABASE ID RELEASE 60%9438649 MAPK6 MAPK4 signaling 291983 289924 313838 361505 361195 25193 289990 58840 360635 310806 54268 309175 58854 84482 307821 29425 64156 29432 83806 287670 29675 294515 50522 29671 29670 24968 24967 25581 29666 100910732 117263 117262 364814 290206 161475 85492 363875 83499 29614 29669 689852 84009 64465 303353 681260 85252 287716 29668 292766 293508 361384 54237 25636 29677 29672 365388 81827 498837 287772 24471 100912032 287984 29431 29433 311078 94198 29630 498183 296651 408248 KERATAN SULFATE DEGRADATION%REACTOME%R-RNO-2022857.1 Keratan sulfate degradation 83717 316033 294673 291015 84400 64507 314771 81682 103690116 300757 COX REACTIONS%REACTOME%R-RNO-140180.1 COX reactions 24693 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 60%9438807 Activation of Nicotinic Acetylcholine Receptors 170945 25102 25101 171131 25590 25302 65024 29422 81721 25103 54240 54239 79557 CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME DATABASE ID RELEASE 60%9438348 Conjugation of phenylacetate with glutamine 246263 361638 AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%R-RNO-141424.1 Amplification of signal from the kinetochores 680006 297176 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME DATABASE ID RELEASE 60%9439038 Non-integrin membrane-ECM interactions 54250 59086 25615 24628 25216 81634 29302 24680 29647 25678 114489 60391 24856 29169 25266 24771 OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME%R-RNO-190704.1 Oligomerization of connexins into connexons 29584 24392 GLYCINE DEGRADATION%REACTOME%R-RNO-6783984.1 Glycine degradation 306586 298942 309312 171133 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME%R-RNO-76009.1 Platelet Aggregation (Plug Formation) 691992 307171 116669 100911551 313494 24366 361714 116727 24185 25661 502858 25259 315707 361969 24367 29302 29434 685269 295347 83805 24175 81745 25083 54245 25614 81504 59326 171337 313845 252857 24697 25414 29251 85385 25155 TRANSCRIPTIONAL REGULATION BY TP53%REACTOME%R-RNO-3700989.1 Transcriptional Regulation by TP53 26954 64562 287871 56718 117281 282844 301518 295052 298514 140926 115771 282845 292804 310131 117526 64525 81807 103694903 29517 114212 362817 364298 296648 308869 60445 300711 311575 114494 64226 25405 295234 298696 24855 25533 58983 24942 81745 360917 299805 312227 691318 363221 301513 310091 308311 306492 295707 363603 24672 291841 24673 297960 314856 116550 64557 304798 288533 100910954 311796 100361529 291773 25562 64012 682902 685055 294018 305851 291787 294258 293345 287608 498411 294800 310784 310034 171152 497672 100360100 306347 81785 497856 310511 305455 315969 24377 307641 116549 307485 170844 314818 308607 305909 83803 24185 65248 311546 360776 261730 295357 315648 78975 100909655 117044 116484 498183 117043 313048 307511 171150 364382 362485 114851 289561 362675 83571 294693 116468 25729 288003 103690054 689314 303241 364834 361365 362594 292064 290995 25737 100910137 84389 64156 292778 690966 686781 313777 361374 290744 59102 305025 308415 304758 25203 305837 288651 171355 691278 50522 83722 83712 362342 502227 306571 290669 299694 297893 297822 117017 362110 365895 362834 689820 140923 363292 83503 29619 315291 360471 58936 291703 192350 290805 64046 116671 100362315 363924 117535 306734 301014 85482 64314 361724 308755 361836 311613 362479 681260 289372 498109 685619 100361574 304528 500715 84576 100911519 103690163 100359464 362272 100361543 363633 287524 314862 498837 266713 314465 100912032 296883 25112 100912534 294236 288414 246334 498453 140908 361580 293625 24887 294518 362045 502894 306998 58819 316123 117254 140942 313017 29753 25576 298795 56011 56010 81674 25577 502988 116686 89812 84577 114592 315713 81650 81649 114495 362078 308472 54237 361798 685474 314756 310614 679713 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 60%9439232 Fanconi Anemia Pathway 309643 24361 361435 292127 309256 102555079 685055 301014 502320 681260 64156 313387 688845 59102 292673 50522 287524 302953 498837 100912032 305600 296883 499155 501552 303742 100360594 293678 287634 293489 360847 INTERCONVERSION OF POLYAMINES%REACTOME%R-RNO-351200.1 Interconversion of polyamines 501620 308652 302642 293589 RNA POLYMERASE I TRANSCRIPTION%REACTOME%R-RNO-73864.1 RNA Polymerase I Transcription 171150 294693 303241 310511 84389 690966 50689 84577 308415 288651 64520 83712 502227 290669 297893 25574 362834 363017 117526 297093 690450 680493 361420 83503 313245 301246 83582 102551184 83581 362728 361784 291703 100360868 117535 680097 295277 361724 100912489 117056 364723 103693372 680172 498109 100361574 84576 291159 100362346 102548682 304714 499766 100360950 361798 500351 679983 266713 691496 102557184 310614 306274 287710 100912534 294236 313048 361580 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 60%9438286 Prolonged ERK activation events 291983 171109 24514 246145 289924 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 58854 102552659 170668 29425 65179 24408 25167 64030 59109 24716 24410 24412 117281 24446 498576 29675 29671 29670 29376 24968 24967 29372 690919 25704 112400 29666 24337 24329 117263 117262 116663 364814 290206 24592 103694903 64022 161475 360814 24703 83499 24245 24244 25267 309179 29614 29496 295234 29211 689852 64363 24497 652957 116630 140924 114103 295347 24246 303353 289257 84423 84422 29668 29495 25614 292766 691318 25266 362572 360573 60427 24672 309168 365388 81827 24673 288924 171081 24242 94198 291245 296072 29630 81511 296651 408248 304893 24586 25746 116590 307821 50689 85492 83613 312754 300980 66023 25525 25326 314612 305203 312664 25136 432361 287716 114858 58960 192126 29542 192213 25467 192117 364052 246150 315648 305614 299147 288589 25400 25150 59323 25344 171140 84598 29613 170577 116478 25054 59325 25433 25676 310533 64156 50522 25581 287942 89807 310738 89804 83805 681260 64159 498837 100912032 362045 56011 79114 81504 170633 83806 170700 313845 54250 287670 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 25114 25738 25022 29368 116499 60662 85385 170582 24525 66017 60464 29669 24225 81737 25730 54245 100911248 29677 63881 29672 287772 287984 311078 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME DATABASE ID RELEASE 60%9438873 Antigen processing: Ubiquitination & Proteasome degradation 291983 303024 289924 289990 298317 305268 58854 29425 64156 294790 29675 50522 29671 29670 24968 25581 24967 29666 117263 117262 364814 290206 161475 83499 29614 689852 303353 681260 29668 292766 300084 365388 81827 498837 312647 100912032 94198 29630 296651 408248 100910646 300968 362900 307821 308968 100359528 288921 313722 362376 140941 366854 83806 310363 117553 303336 363083 100360914 287670 300849 306825 317241 171043 500587 311373 690769 81815 85273 308283 678726 301674 364681 306129 50558 311881 313782 313101 292757 361765 498089 303215 362367 85492 287552 140593 498941 300724 117524 100125363 309444 362002 291597 362081 361907 362277 29669 363188 498959 362511 64517 301015 302987 312504 305424 301000 313806 494223 308999 287716 60383 360818 363790 304522 361354 309453 316575 362356 308901 192351 29677 29672 287772 287280 287984 311078 314432 TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 60%9438477 TNFR2 non-canonical NF-kB pathway 291983 498769 303024 500910 289924 360548 289990 156767 58854 84349 25069 307821 29425 64156 683163 171369 25008 296872 83806 117553 360640 287670 29675 50522 301133 29671 301132 29670 24968 500318 60371 24967 25581 100360982 29666 361509 78971 117263 117262 364814 309361 361765 290206 302424 85492 161475 498666 83499 29614 29669 689852 287437 303353 681260 103694380 287716 29668 292766 362356 302965 365581 29677 498206 29672 500592 365388 500590 81827 309452 311786 498837 287034 287772 89814 287280 100912032 287984 103694381 311078 353218 94198 366518 29630 25572 296651 103689974 408248 25341 362788 297604 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME%R-RNO-75876.1 Synthesis of very long-chain fatty acyl-CoAs 102549542 114024 499018 498962 171410 117243 301120 309449 113976 679532 498728 191576 84013 680115 94340 25288 171400 171402 G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME%R-RNO-418217.1 G beta:gamma signalling through PLC beta 29322 24654 24400 METABOLISM OF INGESTED H2SEO4 AND H2SEO3 INTO H2SE%REACTOME%R-RNO-2408550.1 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se 294103 116686 ERK1 ERK2 PATHWAY%REACTOME DATABASE ID RELEASE 60%9438020 ERK1 ERK2 pathway 291983 171109 24514 246145 289924 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 58854 102552659 170668 29425 65179 24408 25167 64030 24716 24410 24412 117281 24446 498576 29675 29671 29670 29376 24968 24967 29372 690919 25704 112400 29666 24337 24329 117263 117262 116663 364814 290206 24592 103694903 64022 161475 360814 24703 83499 24245 24244 25267 309179 29614 29496 295234 29211 689852 64363 24497 652957 116630 140924 114103 24246 303353 289257 84423 84422 29668 29495 25614 292766 691318 25266 362572 360573 60427 24672 365388 309168 81827 24673 288924 171081 24242 94198 291245 296072 29630 81511 296651 408248 304893 24586 25746 116590 307821 50689 85492 83613 312754 300980 66023 25525 25326 314612 305203 312664 25136 432361 287716 114858 58960 192126 29542 192213 25467 192117 364052 246150 315648 305614 299147 288589 25400 25150 59323 25344 171140 84598 170577 59325 25433 25676 310533 64156 24498 50522 25581 89807 89804 83805 681260 64159 498837 100912032 362045 56011 79114 81504 170633 83806 170700 313845 54250 287670 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 25114 25022 29368 116499 25622 60662 85385 170582 25205 24525 66017 60464 29669 54237 29677 29672 287772 287984 311078 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 60%9437950 U12 Dependent Splicing 303607 289561 687711 362990 316123 302670 287170 103690054 680737 364834 361365 171365 81674 292778 689116 690966 293671 84486 366276 291794 292019 117017 296126 100360682 83503 501926 363082 360803 362687 291060 498425 691538 680891 298075 287530 689890 498109 287739 100361574 300092 494445 300208 680309 295270 681031 363633 100359574 100911462 684148 362264 100912534 687679 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME DATABASE ID RELEASE 60%9437932 The canonical retinoid cycle in rods (twilight vision) 266761 362757 25056 353252 25703 64047 89826 24711 266714 24856 293049 314264 363071 310836 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 60%9438901 Erythrocytes take up oxygen and release carbon dioxide 287167 100134871 103694857 54231 310218 689064 361619 25632 65207 24779 25240 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 60%9437938 SOS-mediated signalling 291983 171109 24514 246145 289924 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 58854 102552659 170668 29425 65179 64156 24408 25167 64030 24716 24410 24412 117281 24446 498576 29675 50522 29671 29670 29376 24968 25581 24967 29372 690919 25704 112400 29666 24337 24329 117263 117262 116663 364814 290206 24592 103694903 64022 161475 360814 24703 83499 24245 24244 89807 25267 309179 89804 29614 29496 295234 29211 689852 64363 24497 652957 116630 140924 114103 24246 83805 303353 289257 681260 84423 84422 29668 29495 25614 64159 292766 691318 25266 362572 360573 60427 24672 309168 365388 81827 24673 498837 100912032 288924 171081 24242 291245 94198 296072 29630 81511 296651 408248 304893 24586 25746 362045 116590 56011 307821 79114 81504 170633 50689 83806 170700 313845 287670 54250 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 25114 25022 29368 116499 60662 85385 170582 85492 24525 66017 60464 83613 312754 29669 300980 66023 25525 25326 314612 305203 312664 25136 432361 287716 114858 29677 58960 192126 29672 29542 192213 25467 192117 364052 287772 246150 315648 305614 299147 287984 288589 25400 25150 311078 59323 25344 171140 84598 170577 59325 25433 25676 310533 ORGANIC CATION TRANSPORT%REACTOME%R-RNO-549127.1 Organic cation transport 29503 29504 29726 50662 24904 GENERIC TRANSCRIPTION PATHWAY%REACTOME%R-RNO-212436.1 Generic Transcription Pathway 289924 79240 292804 364298 308869 295234 298696 303353 25533 58983 25329 24942 360917 299805 312227 363221 301513 308311 306492 295707 363603 365388 291841 94198 116700 314856 304798 311796 100910954 25562 305851 294258 287608 306347 81785 305455 307641 116549 24890 314993 314818 308607 25747 25271 307511 362485 362675 114851 83571 83574 25729 300807 306862 252917 58839 303241 361630 100363472 360896 619579 311807 499670 292064 361128 290995 58850 100910137 58853 50659 60349 361391 686781 679028 313777 361374 290744 25664 305025 25203 305837 114491 171355 691278 83722 54278 25682 362342 297767 290669 25581 299694 365744 297822 252924 362125 365895 362834 140923 259241 299210 685072 29619 306817 58936 684085 192350 290805 299810 64046 116671 245980 100362315 304514 363924 24831 117535 306734 116698 293701 301014 85482 64314 117274 361724 24706 308755 24705 301285 309288 361836 65035 311613 289372 685619 83826 294276 100911519 103690163 25149 100359464 362272 303101 100361543 314862 100909544 314465 307829 81808 24873 25735 25112 497991 81812 308582 246334 140908 84385 293625 100365683 24887 362045 306998 89812 83806 84577 287670 114592 315713 81650 81649 362280 363287 114490 29669 362078 29417 25154 361798 29677 29672 58852 685474 58851 25496 314756 56761 287772 406162 310614 679713 287984 311078 29492 60351 291983 26954 289990 58854 29425 64562 287871 56718 117281 282844 301518 29675 298514 295052 140926 29671 115771 29670 282845 24968 24967 29666 117263 310131 117262 117526 64525 81807 103694903 29517 114212 161475 362817 296648 60445 300711 311575 114494 64226 25405 83499 29614 689852 24855 29668 81745 292766 691318 310091 24672 81827 24673 29630 296651 408248 297960 64557 116550 288533 100361529 291773 64012 682902 685055 294018 291787 498411 293345 294800 310784 171152 310034 497672 100360100 310511 497856 315969 307821 24377 307485 170844 54244 85492 305909 83803 24185 65248 360776 311546 287716 295357 261730 315648 78975 100909655 117044 116484 498183 117043 313048 171150 364382 289561 294693 116468 288003 103690054 689314 301442 364834 362594 361365 25737 84389 64156 292778 690966 59102 308415 304758 288651 59086 300947 50522 29357 365894 690516 83712 306571 680111 502227 114208 499929 297893 300813 362110 117017 689820 363445 363292 84396 25631 81920 360801 83503 315291 360471 100360427 58919 361178 25591 116651 316742 291703 83805 362479 681260 498109 100361574 304528 500715 84576 25573 500695 641452 24790 295062 363633 287524 498837 266713 100912032 296883 363014 100912534 294236 288414 498453 361580 294518 502894 316123 58819 117254 140942 313017 29753 25576 298795 56011 361831 56010 81674 25577 502988 116686 24525 114495 308472 54237 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 60%9438698 cGMP effects 308899 29691 171115 25310 63885 25262 29516 81743 191569 25523 140928 50678 GLUCOSE METABOLISM%REACTOME%R-RNO-70326.1 Glucose metabolism 100364062 362029 29353 315722 140671 289608 296973 25623 64156 114508 60416 81829 64561 685076 29743 24645 24701 25104 361377 117281 299052 24959 64035 50522 24362 25721 24551 25741 25630 309513 289827 292804 24191 362282 103694903 24333 24334 246255 64201 24244 114005 24849 117276 81675 287115 100911625 681260 367562 24190 364682 170943 24401 25636 24672 54283 24673 498837 24385 315648 25059 100912032 24651 25438 24189 100911725 24242 24640 100362738 24644 65152 690987 289632 66020 24638 ERBB2 REGULATES CELL MOTILITY%REACTOME%R-RNO-6785631.1 ERBB2 Regulates Cell Motility 297173 29496 298787 690919 307483 112400 24337 24329 432361 102552659 59323 64022 59325 25433 TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-RNO-8864260.1 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 299810 114491 306862 114490 301442 311807 301285 24890 314993 25329 306817 25573 116700 362280 54244 ARMS-MEDIATED ACTIVATION%REACTOME%R-RNO-170984.1 ARMS-mediated activation 291983 171109 24514 246145 289924 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 58854 102552659 170668 29425 65179 24408 25167 64030 59109 24716 24410 24412 117281 24446 498576 29675 29671 29670 29376 24968 24967 29372 690919 25704 112400 29666 24337 24329 117263 117262 116663 364814 290206 24592 103694903 64022 161475 360814 24703 83499 24245 24244 25267 309179 29614 29496 295234 29211 689852 64363 24497 652957 116630 140924 114103 295347 24246 303353 289257 84423 84422 29668 29495 25614 292766 691318 25266 362572 360573 60427 24672 309168 365388 81827 24673 288924 171081 24242 94198 291245 296072 29630 81511 296651 408248 304893 24586 25746 116590 307821 50689 85492 83613 312754 300980 66023 25525 25326 314612 305203 312664 25136 432361 287716 114858 58960 192126 29542 192213 25467 192117 364052 246150 315648 305614 299147 288589 25400 25150 59323 25344 171140 84598 29613 170577 116478 25054 59325 25433 25676 310533 64156 50522 25581 89807 310738 89804 83805 681260 64159 498837 100912032 362045 56011 79114 81504 170633 83806 170700 313845 54250 287670 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 25114 25022 29368 116499 60662 85385 170582 24525 66017 60464 29669 24225 81737 25730 54245 29677 29672 287772 287984 311078 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME DATABASE ID RELEASE 60%9438181 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 81750 306608 25295 58935 24946 260320 29251 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 60%9438619 Loss of Nlp from mitotic centrosomes 29753 304740 302661 114482 29214 308064 305467 683722 56010 252921 299331 117281 24679 680991 691918 362504 361634 29167 680477 305909 305882 29479 64462 293844 100911033 300963 363055 83572 81740 315423 367153 116659 500069 291540 294010 690209 311191 192228 64158 299850 316531 309692 296554 100362495 311529 305288 311802 311573 54237 286919 360672 299730 58822 310344 83836 103690034 290626 305002 246150 114764 311886 29213 60347 84593 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%R-RNO-2559582.1 Senescence-Associated Secretory Phenotype (SASP) 290875 114483 114851 361389 83571 116590 296558 291689 366381 311412 100360936 361831 81771 304490 64156 94201 50689 54238 25164 295052 50522 100912585 114509 362817 102551184 114494 100360868 680097 295277 100912489 117056 362078 364723 681260 103693372 501560 291159 102548682 314642 100360950 361798 500351 679983 498837 296368 360643 691496 498030 117269 102557184 100912032 305420 293155 24253 OTHER SEMAPHORIN INTERACTIONS%REACTOME%R-RNO-416700.1 Other semaphorin interactions 313498 312652 310207 311384 362398 361537 296789 301227 306790 315711 363517 SCAVENGING OF HEME FROM PLASMA%REACTOME DATABASE ID RELEASE 60%9439029 Scavenging of heme from plasma 312701 503164 103694857 689064 299858 287167 300060 100134871 58917 315108 25632 361619 25081 25377 THE NLRP1 INFLAMMASOME%REACTOME DATABASE ID RELEASE 60%9438819 The NLRP1 inflammasome 24224 360557 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 60%9438121 Muscle contraction 65195 114493 171138 140728 29658 84020 25471 140447 140448 305679 29686 140726 682930 140727 312668 117018 58942 24584 25365 312492 29161 289759 365377 117557 100909725 501831 686098 25687 282843 29553 24852 116491 24851 59324 29715 25297 116695 24245 361618 24244 24239 140724 140725 64190 294141 24246 140729 84347 683667 24598 116564 64672 114593 24602 24603 308405 89821 259243 289596 24215 25560 25118 24213 24211 24214 24212 501203 29598 689560 29599 24242 291245 83535 25650 29132 56817 59299 100911951 65199 362013 29712 29716 367086 117052 276720 688228 58950 25566 29248 24585 171409 64362 29388 29693 29389 56781 306243 116649 24838 63847 24837 29600 171009 290561 296369 24583 295929 24907 63848 292879 29639 116831 81678 25391 100910474 25390 313494 25679 25262 81818 25665 287419 102551071 296313 116600 170630 63851 170632 84488 300992 500450 685867 360820 246150 362816 24582 25400 156873 288057 100909726 171140 304447 50688 685883 INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME DATABASE ID RELEASE 60%9439286 Interaction between PHLDA1 and AURKA 29380 261730 ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 60%9439319 Aryl hydrocarbon receptor signalling 25243 498999 25242 301252 282827 25690 367808 362809 TNF SIGNALING%REACTOME%R-RNO-75893.1 TNF signaling 100910771 683206 317546 100362554 246244 353233 308267 83427 103694380 681260 60383 64156 687813 361167 364386 64044 312937 266610 313121 50522 311786 246756 60371 57027 498837 100912032 78971 94193 306886 311401 361373 308493 309361 309295 94338 315139 84351 83537 100911911 362828 81859 FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE%REACTOME DATABASE ID RELEASE 60%9439059 Ficolins bind to repetitive carbohydrate structures on the target cell surface 114091 64023 64459 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 60%9438408 Synthesis of bile acids and bile salts via 27-hydroxycholesterol 307092 25429 171516 191574 25271 291283 60351 83724 313929 192242 81924 246211 PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME DATABASE ID RELEASE 60%9438640 Protein-protein interactions at synapses 116470 29629 29628 24408 24410 24412 83527 362876 293645 140592 140591 685472 286923 294380 116681 24414 29548 116595 79146 29547 58948 29546 81859 64053 500219 25252 64353 313052 304733 83589 25466 171297 59312 679668 83610 78957 65040 286930 117096 116724 309557 103690160 309349 60377 306147 313278 29647 25558 688721 308495 24409 116647 308918 246212 60391 140945 29495 310519 365222 83764 308571 306152 290467 360406 312855 316205 29613 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME%R-RNO-418885.1 DCC mediated attractive signaling 25150 309081 114523 682507 300955 25311 25614 363875 310192 64465 83805 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%R-RNO-446210.1 Synthesis of UDP-N-acetyl-glucosamine 302972 498272 360518 304954 498486 297417 297393 81759 363109 HYALURONAN BIOSYNTHESIS AND EXPORT%REACTOME%R-RNO-2142850.1 Hyaluronan biosynthesis and export 116721 282821 308797 266805 DEGRADATION OF GABA%REACTOME DATABASE ID RELEASE 60%9438832 Degradation of GABA 81632 291133 MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 60%9438204 Mitochondrial transcription initiation 299604 83474 289307 VLDL CLEARANCE%REACTOME%R-RNO-8964046.1 VLDL clearance 25292 100910181 54225 680551 499264 25696 FRUCTOSE CATABOLISM%REACTOME DATABASE ID RELEASE 60%9437831 Fructose catabolism 24190 361730 25659 684314 BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME%R-RNO-1307965.1 betaKlotho-mediated ligand binding 170582 25114 CARDIAC CONDUCTION%REACTOME DATABASE ID RELEASE 60%9438120 Cardiac conduction 29712 29716 367086 65195 114493 171138 140728 117052 29658 84020 276720 25471 140447 140448 58950 29686 29693 306243 116649 140726 63847 682930 29600 140727 312668 117018 58942 63848 29639 116831 81678 100909725 29553 116491 59324 25391 25390 116695 25297 29715 24245 361618 24244 25679 25262 24239 140724 140725 64190 294141 24246 25665 287419 140729 116600 84347 683667 24598 170630 63851 170632 84488 64672 116564 114593 300992 24602 24603 308405 89821 259243 289596 24215 25560 24213 246150 24211 24214 24212 25400 29598 156873 689560 29599 24242 83535 171140 25650 50688 29132 56817 100911951 59299 65199 362013 NON-CODING RNA METABOLISM%REACTOME DATABASE ID RELEASE 60%9438407 Non-coding RNA Metabolism 286917 364382 687711 680737 171365 689116 100911453 291794 312947 100360682 310769 53372 294429 691231 300259 65160 299706 292085 117021 304862 298075 58958 245922 113929 65274 287830 84473 316108 363462 116555 499391 362281 685068 362688 25281 84404 680309 683983 497958 64301 295692 681031 291874 81738 499974 113975 25497 362335 687679 TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME%R-RNO-432030.1 Transport of glycerol from adipocytes to the liver by Aquaporins 65054 29171 TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME%R-RNO-5578749.1 Transcriptional regulation by small RNAs 289561 103690054 364834 361365 292778 690966 117017 83503 102551184 53372 294429 300259 299706 100360868 680097 292085 117021 59117 304862 295277 100912489 117056 364723 58958 245922 113929 65274 103693372 498109 287830 100361574 308971 84509 291159 102548682 116555 362281 25281 100360950 683983 295692 500351 291874 81738 499974 363633 313594 679983 113975 691496 102557184 25497 362335 100912534 OXIDATIVE DEMETHYLATION OF DNA%REACTOME DATABASE ID RELEASE 60%9439120 Oxidative demethylation of DNA 114521 HSF1-DEPENDENT TRANSACTIVATION%REACTOME DATABASE ID RELEASE 60%9439092 HSF1-dependent transactivation 24245 689955 301252 286899 113906 367808 362809 24246 24963 25400 292887 25420 260321 79245 171140 287871 361384 64226 56718 54244 299331 AXONAL GROWTH STIMULATION%REACTOME DATABASE ID RELEASE 60%9438430 Axonal growth stimulation 310738 24596 297173 360678 MMR%REACTOME DATABASE ID RELEASE 60%9439133 MMR 59294 100360342 287524 81685 81709 361698 296883 25737 499505 289758 59102 81513 100911727 NADPH REGENERATION%REACTOME%R-RNO-389542.1 NADPH regeneration 24479 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME%R-RNO-430116.1 GP1b-IX-V activation signalling 691992 116669 100911551 116727 293860 502858 25259 25513 24703 83805 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME DATABASE ID RELEASE 60%9438116 Elevation of cytosolic Ca2+ levels 81739 282822 29665 114115 60395 25679 89823 25262 29659 113995 25505 25041 STIMULI-SENSING CHANNELS%REACTOME%R-RNO-2672351.1 Stimuli-sensing channels 79430 63866 24767 24768 293874 311287 116477 301111 192675 171497 171498 282822 58950 116469 60395 308022 497948 79425 64156 140933 309407 84494 304315 114246 292168 66026 365391 25688 288371 362247 499287 312896 83810 317420 25749 295041 50522 29232 29233 286920 299714 266730 314401 292597 29517 499474 306811 293735 24703 362053 24244 315272 287715 365946 308016 294141 100912455 681260 294329 683667 367318 63882 679958 89821 60586 89823 361586 25122 171384 498837 100912032 79123 689560 309139 24242 309135 295586 297930 100361584 59299 INSULIN PROCESSING%REACTOME%R-RNO-264876.1 Insulin processing 64632 252881 60627 298786 171455 116654 25121 25204 294698 305287 299903 309533 171562 25669 24506 24505 50556 245709 100911734 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME DATABASE ID RELEASE 60%9439016 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 59086 297173 50522 304193 690516 310655 498837 307799 100912032 81810 681260 64156 29591 81918 25522 103690035 116479 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME DATABASE ID RELEASE 60%9438335 Telomere C-strand (Lagging Strand) Synthesis 100362333 299112 59294 116468 304573 287524 288003 361698 85242 84490 301323 246327 89809 361836 296883 25737 304528 289758 288414 59102 81513 100911727 REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-RNO-975578.1 Reactions specific to the complex N-glycan synthesis pathway 308757 94273 25478 25329 140568 432392 116700 308511 REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-8941858.1 Regulation of RUNX3 expression and activity 314856 291983 289924 29614 29669 689852 289990 83805 303353 58854 681260 307821 287716 29425 29668 64156 361391 292766 83806 29677 287670 59086 29675 29672 50522 365388 29671 81827 29670 690516 24968 498837 25581 24967 287772 100912032 29666 287984 117263 311078 117262 94198 29630 296651 161475 408248 85492 83499 MAPK1 (ERK2) ACTIVATION%REACTOME%R-RNO-112411.1 MAPK1 (ERK2) activation 58960 24514 25622 116590 84598 25205 24498 CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME%R-RNO-173623.1 Classical antibody-mediated complement activation 299354 192262 29687 312705 298566 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME DATABASE ID RELEASE 60%9438267 ZBP1(DAI) mediated induction of type I IFNs 81722 287707 309452 25493 292892 301059 309295 309361 309165 81736 84351 25742 305751 81525 54226 304859 INVADOPODIA FORMATION%REACTOME DATABASE ID RELEASE 60%9439321 Invadopodia formation 57025 303068 679837 309460 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 60%9437895 Cleavage of Growing Transcript in the Termination Region 116697 687711 288701 314417 680737 171365 311166 313449 689116 361814 29667 291877 307524 308335 690303 309338 295284 100360682 362612 361605 501688 366468 313620 361542 362687 292884 681062 315170 290519 361990 287113 303057 361859 89827 298075 360845 362819 679894 305714 313308 360972 302729 689890 683927 299256 114612 500378 79227 291797 298916 292683 304277 494445 292007 687575 366952 681031 688288 311670 365407 362264 298385 687679 MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 60%9439313 MET interacts with TNS proteins 24446 303517 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 60%9438854 TRAF6 mediated induction of TAK1 complex 362418 681260 50522 64156 498837 311245 100912032 RUNX3 REGULATES P14-ARF%REACTOME DATABASE ID RELEASE 60%9439328 RUNX3 regulates p14-ARF 59086 294276 361391 100909544 363287 58919 24525 INTERFERON SIGNALING%REACTOME%R-RNO-913531.1 Interferon Signaling 690894 24514 686326 301442 292892 24481 305896 500491 306204 359726 116689 50689 100911527 100912571 360697 24697 25124 117063 100912356 300772 89829 252971 116465 300756 25738 100361294 25622 295704 170538 25712 287436 363275 288774 312688 100912314 24245 298205 361628 298211 298210 24246 301000 367264 297481 298693 501116 688288 288264 361390 298573 502965 502966 116725 502962 117045 25400 171140 84598 103690314 24667 303831 COENZYME A BIOSYNTHESIS%REACTOME%R-RNO-196783.1 Coenzyme A biosynthesis 363069 296167 103689921 298490 294088 287711 ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME%R-RNO-112303.1 Electric Transmission Across Gap Junctions 50564 313126 266706 315435 SYNDECAN INTERACTIONS%REACTOME DATABASE ID RELEASE 60%9439058 Syndecan interactions 24680 54250 29647 59086 25615 29169 25216 81634 29302 24771 NADE MODULATES DEATH SIGNALLING%REACTOME%R-RNO-205025.1 NADE modulates death signalling 310738 117089 24596 25402 64314 29753 OPTINEURIN AND MYOSIN PHOSPHATASE NEGATIVELY REGULATE PLK1%REACTOME%R-RNO-2562597.1 Optineurin and Myosin Phosphatase Negatively Regulate PLK1 117103 246294 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-RNO-194313.1 VEGF ligand-receptor interactions 89811 94203 54251 114110 83785 25589 114111 360457 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%R-RNO-186712.1 Regulation of beta-cell development 84482 24185 83630 29458 60329 366214 NUCLEAR ENVELOPE REASSEMBLY%REACTOME DATABASE ID RELEASE 60%9439071 Nuclear Envelope Reassembly 25437 114087 60374 24672 362779 103694903 117104 117281 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 60%9438061 Downstream signal transduction 291983 171109 24514 246145 289924 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 361696 58854 294048 102552659 64545 170668 84482 29425 65179 24408 25167 64030 24954 50686 79240 24716 24506 24410 24505 24412 294235 56718 117281 84027 24446 498576 29675 294515 29671 365367 29670 59265 29376 24968 24967 29372 690919 25704 112400 29666 24337 24329 117263 310131 117262 116663 170538 364814 140607 290206 24592 103694903 246273 64022 161475 296648 360814 24703 64226 83499 24245 24244 25267 309179 29614 29496 29211 295234 689852 64363 24497 652957 116630 140924 114103 24246 24855 303353 289257 84423 361992 84422 29668 81745 29495 25614 292766 691318 25266 362572 360573 60427 24672 309168 365388 81827 24673 365865 292887 288924 171081 24242 291245 94198 296072 29630 81511 296651 408248 304893 24586 25746 314856 116590 25050 307821 50689 81678 85492 25233 83613 312754 24185 300980 66023 25525 25326 314612 305203 312664 50557 25136 432361 287716 114858 58960 192126 29542 29414 192213 25467 192117 364052 25414 246150 315648 305614 299147 288589 25400 25150 59323 25344 171140 84598 170577 59325 25433 25676 310533 114851 83571 366508 25238 54223 362896 314641 305509 64156 64508 84420 29699 24679 50522 24681 25581 29241 287942 309361 81646 89807 29741 89804 84427 85243 83805 24680 681260 302415 300955 64159 58918 29691 498837 100912032 316369 309419 362045 56011 79114 81504 170633 25513 89812 83806 170700 313845 287670 54250 25443 25444 170579 316213 293621 314850 25317 170583 25124 29348 29349 84489 24605 361388 25125 25114 25738 25022 29368 116499 25622 100363500 60662 85385 170582 24525 66017 25156 60464 25679 25262 29669 25521 24918 25289 25725 54245 64532 367264 293508 56822 25636 100911248 25408 29677 25660 63881 29672 302950 287772 287984 311078 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%R-RNO-1810476.1 RIP-mediated NFkB activation via ZBP1 81722 287707 309452 25493 301059 309295 309361 309165 81736 84351 25742 305751 81525 304859 54226 VESICLE-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 60%9438396 Vesicle-mediated transport 252902 306332 25183 24506 24505 50645 689064 499985 25073 64310 297872 303734 311919 287535 360956 288700 302552 100360087 25532 501854 117051 84589 500249 364981 501069 309922 25218 286932 64187 100362805 293344 100361513 24942 296649 291309 367308 301012 287709 289994 310411 171121 300674 361407 361207 100910318 299075 361073 300888 309451 303652 94197 361697 293456 102555167 246117 291990 116666 362599 79120 309144 100363782 81754 304978 64558 309010 84599 65134 360709 361705 361577 50993 100912115 60355 500251 100910557 363858 680465 306264 56042 89868 690252 64154 171049 690961 362162 54350 64351 360611 29631 140673 361502 363136 100360302 315345 100909916 192243 29183 503165 58842 94189 24827 297428 317580 366896 292886 501550 360968 292074 365372 309678 287276 290659 287110 266688 362237 313234 311911 361227 499768 56082 25081 246294 100126191 360426 289350 365191 362504 29167 114113 100359937 64670 367038 294324 81655 362466 367304 29564 83572 290798 360785 84428 116659 361916 140734 308961 364419 292090 24653 360827 299850 282834 302671 29663 79214 679886 64862 58974 302470 287873 306117 81756 363720 360937 81757 117103 288669 64678 54225 65046 317576 60443 25238 682507 84018 124461 313413 310839 192348 500244 314641 79121 60465 25710 311880 309129 313409 25490 60668 306570 246310 24803 361244 29491 24805 29448 317396 60564 85238 25716 287427 79128 116561 24197 103690020 116563 64189 83800 140694 25751 81732 24176 192154 192152 300678 303251 25319 29292 84357 25108 116500 25728 64159 363266 314349 308578 117028 117106 683687 266606 89816 300438 81659 140670 290639 297518 361120 25387 25531 312689 364033 83730 29528 64566 24825 25388 312694 85491 25151 361632 81917 100359675 54241 500564 311030 81645 100909548 116743 25407 498798 81637 85256 103694857 25423 315840 29184 94193 24221 252929 290635 308178 362118 687208 297995 292925 100910929 288659 290775 362044 309159 292640 290851 171529 287624 681059 314473 171304 315131 140932 304290 360953 690073 289820 290627 689955 310746 65165 302290 114023 291464 311404 295217 288785 689256 84392 360515 641528 314906 680476 84393 289168 309969 296284 363476 84391 362609 296199 362186 25306 293502 300147 29662 83576 100134871 294900 317630 364183 85248 362502 360834 287645 315298 315740 289312 300060 64023 58917 315108 64202 25377 361289 24791 367391 312701 498854 366588 362862 503164 299858 282580 498638 24329 60445 29211 24855 289257 100365047 360854 307039 310710 361619 64516 84379 24185 64462 316130 305614 304343 500985 287367 363283 287167 312710 64156 314393 261736 25632 363273 81803 50522 24392 292994 83805 681260 690407 313493 500906 309306 60562 116691 310526 116693 116692 116639 315668 299258 308821 498837 29584 365793 394266 266706 100912032 360915 54226 79434 313017 29753 25576 298795 56011 56010 295461 25577 81504 312257 93646 306229 691042 290746 103689930 114638 252916 361987 311494 299799 315999 360797 171452 315756 304555 287275 315055 314013 365042 316017 25530 207119 308942 291750 310843 363235 311913 314397 289051 294709 362983 308944 360768 24932 361459 366618 304344 100911794 81830 685144 100362547 366311 171575 58817 297522 363059 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%R-RNO-425366.1 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds 171148 306009 80878 291733 85256 171147 25362 25552 363024 170580 366251 25715 83511 29735 305846 310625 170840 503568 116509 314637 65202 65200 365398 65207 171135 29503 365962 117100 293048 24898 113918 50676 298786 298340 294255 117240 25027 363985 289459 29504 25139 360539 64522 29509 171163 294698 29464 361986 24904 24778 58976 308028 295417 65197 282712 316519 79213 294281 79212 299903 89776 295455 85426 664630 296600 64846 29726 54302 25246 501925 362861 50662 58980 24268 25351 366441 252854 289353 29323 54301 25693 300051 NEDDYLATION%REACTOME DATABASE ID RELEASE 60%9439219 Neddylation 362093 361181 303024 500367 304343 680076 315745 290692 287367 363283 312710 500616 360860 499016 64156 25490 300950 261736 300948 305895 498560 294790 363273 296627 503446 50522 685860 83712 89829 303792 117519 305792 306073 361509 316131 64345 100911548 64525 81920 81807 24874 299266 29560 365277 313348 289831 361258 361268 29452 304920 681260 499972 362762 100911374 641452 297592 64470 313445 300084 84019 310071 303602 498837 304794 117537 367785 100912032 100362121 360915 317381 363259 314273 302502 314457 688993 363284 361187 315287 307893 688813 361831 353227 362566 100359528 360928 288921 313722 500262 362902 311633 364227 117152 366854 310363 117553 303336 363083 100360914 498005 300849 103694000 171043 500587 85273 308283 315723 316228 678726 301674 100909827 306129 307200 311881 313782 313101 292757 361765 64041 303215 498941 300724 117524 83681 100125363 309444 362081 316628 361907 313743 498959 362511 364050 301015 302981 312504 287706 305424 302288 494223 308999 289181 313020 360818 363790 304522 305073 687364 361354 313242 309453 305351 362356 192351 309035 302666 315405 287280 293060 293023 690367 316614 288692 310324 500050 CASP8 ACTIVITY IS INHIBITED%REACTOME DATABASE ID RELEASE 60%9439093 CASP8 activity is inhibited 306886 266610 246775 25385 246097 117279 311786 246756 64044 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 60%9438210 Class B 2 (Secretin family receptors) 24953 24400 171519 685451 60449 25026 81667 58965 25024 24166 64199 56820 24769 60432 81648 25051 294962 114120 83579 114118 25040 24476 114119 117064 114117 81779 79218 24241 29446 399475 690825 170896 25321 100912034 680149 56813 64680 29555 24952 29151 245986 58966 499149 58959 25029 29625 24694 81753 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 60%9437965 Import of palmitoyl-CoA into the mitochondrial matrix 25413 25271 29726 25682 25357 117035 64562 25756 404280 78975 25757 MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME%R-RNO-190840.1 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 24392 P38MAPK EVENTS%REACTOME DATABASE ID RELEASE 60%9438304 p38MAPK events 114858 315994 81649 293621 289014 29622 689314 116546 24525 24605 81757 DEGRADATION OF DVL%REACTOME%R-RNO-4641258.1 Degradation of DVL 291983 289924 289990 58854 307821 29425 64156 83806 291209 83721 287670 29675 500666 50522 29671 29670 24968 25581 24967 29666 117263 117262 364814 290206 161475 85492 83499 303251 303811 29614 29669 689852 303353 681260 287716 29668 292766 29677 29672 300084 365388 81827 498837 287772 100912032 287984 311078 94198 29630 296651 408248 DNA DAMAGE BYPASS%REACTOME DATABASE ID RELEASE 60%9438041 DNA Damage Bypass 361181 316344 84478 313702 116468 309812 288003 301000 100147704 300795 289508 681260 25737 291526 140639 64156 304528 494338 292101 289758 305073 313387 688845 298693 59102 64470 59294 50522 300084 316235 287524 498837 307905 361698 100912032 89809 296883 295704 302502 288414 116643 362412 TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME%R-RNO-69895.1 Transcriptional activation of cell cycle inhibitor p21 100910954 685474 INTESTINAL ABSORPTION%REACTOME DATABASE ID RELEASE 60%9438557 Intestinal absorption 432367 NUCLEOTIDE METABOLISM%REACTOME%R-RNO-15869.1 Nucleotide metabolism 311580 315150 191575 58819 311864 303179 100360582 497778 315219 171566 289276 58813 290741 85269 362329 100363253 301005 116686 58964 313560 311422 292072 313574 291585 361068 102238592 684425 363129 29261 64045 298881 291824 365985 682978 301622 117544 305149 290029 499956 24834 117260 685579 497811 65135 287406 287368 287420 312373 171047 290365 295088 288259 314312 361063 24240 64519 295620 309390 29223 117533 64467 316077 362015 613267 79127 85260 362638 192357 299976 289801 83585 25028 362720 361274 288051 24165 304944 103689983 297389 311352 65156 81643 83784 361663 311833 116593 140946 100909857 619580 25095 116484 294521 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME DATABASE ID RELEASE 60%9438087 Formation of the Early Elongation Complex 171150 289561 311796 294693 316123 294258 287608 103690054 298075 364834 361365 305455 81674 498109 100361574 84389 689116 292778 690966 308472 308415 288651 363633 502227 266713 117017 83503 100912534 294236 361580 291703 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 60%9438062 Signaling by PDGF 291983 171109 24514 246145 289924 246144 24628 24629 293847 313874 25453 289990 25597 314596 305104 29434 364686 116562 306628 361696 58854 294048 102552659 64545 170668 84482 29425 65179 24408 25167 24954 25353 64030 50686 79240 24716 24506 24410 24505 24412 294235 56718 117281 84027 24446 498576 29675 294515 29671 365367 29670 59265 29376 24968 24967 29372 690919 25704 112400 29666 24337 24329 117263 310131 117262 116663 170538 364814 140607 290206 24592 103694903 246273 445442 64022 161475 296648 360814 24703 64226 83499 24245 85253 24244 25267 309179 29614 29496 29211 295234 689852 64363 24497 652957 116630 140924 114103 24246 24855 303353 289257 84423 361992 362285 84422 29668 81745 29495 25614 292766 691318 25266 362572 360573 60427 24672 309168 365388 81827 24673 290905 365865 292887 288924 171081 24242 291245 94198 296072 29630 81511 296651 362584 408248 304893 24586 25746 314856 116590 25050 307821 50689 81678 117255 85492 25233 83613 312754 24185 300980 66023 25525 25326 314612 305203 50557 312664 25136 432361 287716 114858 58960 192126 29542 29414 192213 25467 192117 364052 25414 246150 315648 305614 299147 288589 25400 25150 59323 25344 171140 84598 170577 59325 25433 25676 310533 114851 83571 366508 25238 362896 54223 314641 305509 64156 64508 84420 29699 24679 50522 24681 25692 25581 29241 287942 309361 81646 54281 89807 29741 89804 66018 79429 84427 292406 29220 85243 83805 24680 681260 302415 300955 64159 58918 29691 498837 100912032 316369 309419 362045 56011 79114 81504 170633 25513 89812 83806 170700 313845 287670 54250 25443 25444 170579 316213 293621 314850 25317 170583 25124 29348 29349 84489 24605 361388 25125 25114 25738 25022 29368 116499 25622 100363500 60662 85385 170582 24525 66017 60464 25156 25679 25262 29669 25521 24918 25289 25725 54245 64532 367264 293508 56822 25636 100911248 25408 29677 25660 63881 29672 302950 287772 287984 311078 POLYMERASE SWITCHING%REACTOME%R-RNO-69091.1 Polymerase switching 59294 25737 116468 304528 288003 289758 288414 85242 361698 301323 246327 89809 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%R-RNO-2142670.1 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 24297 65030 313375 25426 24296 313373 SYNTHESIS OF KETONE BODIES%REACTOME DATABASE ID RELEASE 60%9437916 Synthesis of Ketone Bodies 24450 65984 367112 314800 79238 25014 295458 TRANSPORT OF ORGANIC ANIONS%REACTOME DATABASE ID RELEASE 60%9438439 Transport of organic anions 140915 84608 80900 171144 140860 50572 259248 24546 432363 80899 170698 24221 84511 58978 NFG AND PRONGF BINDS TO P75NTR%REACTOME DATABASE ID RELEASE 60%9438433 NFG and proNGF binds to p75NTR 310738 24596 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 60%9438929 GRB2 events in ERBB2 signaling 313845 293621 690919 24605 112400 24337 102552659 59323 81504 64022 59325 25433 24525 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 60%9438602 NCAM1 interactions 306628 25454 362285 362584 25453 116696 58982 290905 24586 305104 PKA-MEDIATED PHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 60%9438216 PKA-mediated phosphorylation of key metabolic factors 25636 24638 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%R-RNO-500657.1 Presynaptic function of Kainate receptors 29322 24654 24400 298521 PYRIMIDINE BIOSYNTHESIS%REACTOME%R-RNO-500753.1 Pyrimidine biosynthesis 288051 24240 65156 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%R-RNO-2046104.1 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 498728 679532 363516 170588 24157 83512 25288 84575 309449 171400 50681 79244 RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME%R-RNO-5666185.1 RHO GTPases Activate Rhotekin and Rhophilins 60377 103692165 297173 297383 300030 360564 308516 TRANSLESION SYNTHESIS BY REV1%REACTOME%R-RNO-110312.1 Translesion synthesis by REV1 316344 313702 50522 116468 287524 309812 288003 498837 100912032 89809 296883 681260 25737 64156 304528 288414 59102 NEPHRIN INTERACTIONS%REACTOME%R-RNO-373753.1 Nephrin interactions 361598 100359836 29741 682507 85243 29211 81634 315546 25150 29647 316369 310695 300955 64563 64159 63836 INTERLEUKIN-10 SIGNALING%REACTOME DATABASE ID RELEASE 60%9438773 Interleukin-10 signaling 117539 100361294 25325 304091 84598 25125 JOSEPHIN DOMAIN DUBS%REACTOME%R-RNO-5689877.1 Josephin domain DUBs 361381 681260 315134 50522 64156 498837 60331 116643 100912032 298012 292876 HCN CHANNELS%REACTOME%R-RNO-1296061.1 HCN channels 84390 114245 114244 RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME%R-RNO-5627083.1 RHO GTPases regulate CFTR trafficking 85428 309774 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 60%9439220 Gap-filling DNA repair synthesis and ligation in GG-NER 59294 50522 116468 287524 288003 498837 361698 100912032 89809 296883 681260 25737 64156 304528 289758 288414 59102 HEDGEHOG 'ON' STATE%REACTOME%R-RNO-5632684.1 Hedgehog 'on' state 291983 287612 304832 307724 289711 303968 29499 289924 50938 691171 25238 113927 302661 289990 291936 289712 360715 362549 140588 140589 58854 361769 307821 29425 64156 293047 25273 304318 289180 287643 83806 362265 308577 287670 29675 50522 29671 29670 690516 24968 24967 25581 29666 117263 117262 364814 290206 161475 85492 83499 29614 29669 689852 303353 681260 287716 29668 292766 29677 683470 29672 365388 300084 81827 498837 304729 287772 364475 305918 100912032 89830 25387 361438 287984 84392 311078 25388 94198 29630 296651 408248 TRANSLATION INITIATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 60%9438163 Translation initiation complex formation 300253 296302 29288 288599 140655 362952 681260 100362830 292148 81775 293427 29752 81776 292762 299027 25348 100912571 300069 294282 293484 288516 29236 65139 100360647 297756 498837 103690015 684988 298700 100912032 691531 117045 295975 299872 29284 691947 100911847 687780 287436 29258 100360679 54318 100911110 161477 302697 25538 303831 INHIBITION OF TSC COMPLEX FORMATION BY PKB%REACTOME%R-RNO-165181.1 Inhibition of TSC complex formation by PKB 25233 24855 60445 NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME%R-RNO-5654726.1 Negative regulation of FGFR1 signaling 116590 500985 306141 500526 83805 681260 64156 79114 81504 170633 50689 170700 117281 54250 25443 25444 170579 50522 24672 24673 314850 498837 25317 170583 29349 100912032 29368 116499 25622 60662 103694903 66017 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME%R-RNO-352230.1 Amino acid transport across the plasma membrane 307811 29485 155205 252919 246235 282712 292657 29642 287532 84551 83509 64554 170573 29484 170567 664630 305540 311168 50719 50676 113918 25648 298340 114518 315439 116726 314441 170566 192208 29323 29464 310392 PLASMA LIPOPROTEIN REMODELING%REACTOME%R-RNO-8963899.1 Plasma lipoprotein remodeling 85253 54225 24538 360495 100361444 291437 296371 362850 24530 292697 24539 25728 116548 25507 85264 54281 25649 25081 300027 CAM PATHWAY%REACTOME%R-RNO-111997.1 CaM pathway 29699 24244 24679 29691 25238 302950 54223 24681 29241 25521 24680 25050 25289 24242 25725 170538 305509 100363500 64532 81646 64508 293508 84420 25636 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 60%9438575 GRB2:SOS provides linkage to MAPK signaling for Integrins 313845 307171 116669 313494 24366 25661 361969 24367 29302 685269 295347 83805 81504 25614 171337 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME%R-RNO-163210.1 Formation of ATP by chemiosmotic coupling 192241 140608 114630 26197 26196 100911417 171082 245958 690441 245965 29754 689271 171374 171375 500350 300677 641434 362749 94271 7066252 7066251 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 60%9438997 NOTCH2 Activation and Transmission of Signal to the Nucleus 81517 117258 29492 311332 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%R-RNO-209560.1 NF-kB is activated and signals survival 310738 50522 24596 25493 498837 100912032 681260 363520 64156 113894 309165 311245 81736 84351 RECEPTOR PROTEIN TYROSINE PHOSPHATASES INTERACTIONS%REACTOME%R-RNO-388844.1 Receptor protein tyrosine phosphatases interactions 362876 293645 310519 25466 308571 306152 140592 290467 140591 360406 312855 309349 306147 313278 308918 29613 METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME%R-RNO-6799990.1 Metal sequestration by antimicrobial proteins 170496 301034 116547 PI-3K CASCADE:FGFR1%REACTOME%R-RNO-5654689.1 PI-3K cascade:FGFR1 54250 25443 25444 170579 314850 25317 170583 29349 361388 29368 116499 25622 60662 79114 81504 170633 25513 66017 170700 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 60%9438214 ChREBP activates metabolic gene expression 116719 406165 50671 24159 SYNTHESIS OF GDP-MANNOSE%REACTOME%R-RNO-446205.1 Synthesis of GDP-mannose 302915 300741 501167 300089 HDL ASSEMBLY%REACTOME%R-RNO-8963896.1 HDL assembly 313210 303796 83470 24153 100911545 293508 25636 25081 PKA ACTIVATION%REACTOME DATABASE ID RELEASE 60%9438076 PKA activation 29699 24244 24679 302950 54223 29241 25521 25289 24242 25725 305509 64532 293508 64508 84420 25636 DIGESTION OF DIETARY LIPID%REACTOME%R-RNO-192456.1 Digestion of dietary lipid 25680 25702 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%R-RNO-982772.1 Growth hormone receptor signaling 24918 24514 81515 25235 116590 29376 25467 24391 24697 89817 50689 24683 COMMON PATHWAY OF FIBRIN CLOT FORMATION%REACTOME%R-RNO-140875.1 Common Pathway of Fibrin Clot Formation 65051 24366 362248 361969 79224 289055 29251 24367 83580 25439 360918 81750 100909700 60327 499099 304917 302470 314615 29366 ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 60%9438122 Activation of BID and translocation to mitochondria 259274 64625 266704 502003 171290 171528 691670 691695 100361468 691668 100361261 64044 103690372 100911163 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME%R-RNO-159854.1 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 81750 306608 25295 58935 24946 81716 260320 54281 29251 RESOLUTION OF D-LOOP STRUCTURES%REACTOME DATABASE ID RELEASE 60%9439212 Resolution of D-Loop Structures 64557 290805 497976 64046 499870 64012 499966 303375 306734 291787 85482 497672 497856 308755 360254 361836 293452 498119 689055 298884 302953 102551085 293678 362288 287634 293489 300711 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%R-RNO-2500257.1 Resolution of Sister Chromatid Cohesion 171576 64515 680006 304740 361662 499933 117281 301701 25203 298594 304218 286993 314949 308443 100911204 362548 500545 114592 362965 293733 681050 317252 64041 103694903 63996 684439 290577 294712 29486 304951 305343 304477 313304 315958 294429 65201 298850 501706 299706 287598 312754 309179 363028 363174 292085 362044 691493 289150 305270 171529 287624 83572 361416 24669 315164 295661 85252 287830 684771 311191 291441 681185 116555 691318 25448 683983 54237 316425 363481 296137 81738 24672 257649 83836 24673 297176 257644 315648 114764 299147 170845 29648 307805 498310 114514 84391 311327 362186 306464 360886 297522 303037 363059 MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-390648.1 Muscarinic acetylcholine receptors 25229 53949 25111 24260 81645 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME%R-RNO-72202.1 Transport of Mature Transcript to Cytoplasm 288701 313449 689116 361814 29667 308335 690303 295284 362612 313620 361542 362687 53372 294429 315170 290519 300259 361990 299706 287113 303057 361859 292085 117021 89827 298075 304862 360845 362819 679894 305714 313308 58958 360972 245922 302729 113929 65274 689890 287830 114612 500378 79227 291797 494445 116555 362281 292007 687575 25281 683983 295692 500697 291874 308653 81738 499974 688288 296219 59087 362098 113975 501621 25497 362335 362264 298385 SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME DATABASE ID RELEASE 60%9439073 SUMO E3 ligases SUMOylate target proteins 301442 497672 308669 309595 25737 84577 309995 501145 314949 313961 297561 25094 299957 64520 316164 500545 114592 83422 300772 362965 367152 293733 297893 315713 287662 293967 362827 361645 83614 64550 499179 64041 63996 362280 29486 60373 363287 102551184 313304 25591 53372 315958 294429 300259 299706 680097 114521 292085 117021 304862 295277 100912489 308755 364723 58958 245922 113929 65274 287830 312560 84576 102548682 25573 116555 362281 25281 100360950 683983 295692 500351 291874 81738 499974 296099 313038 679983 287524 113975 102557184 25497 362335 362581 309626 304850 303730 303731 501403 310258 499417 84593 307151 312690 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%R-RNO-113510.1 E2F mediated regulation of DNA replication 24708 24672 103694903 24673 85242 301323 682033 315648 246327 117281 MEMBRANE TRAFFICKING%REACTOME DATABASE ID RELEASE 60%9438395 Membrane Trafficking 252902 306332 25183 24506 24505 50645 64310 297872 303734 311919 287535 360956 288700 302552 100360087 25532 501854 117051 84589 500249 364981 501069 309922 25218 286932 64187 100362805 293344 100361513 24942 296649 291309 367308 301012 287709 289994 310411 171121 300674 361407 361207 100910318 299075 361073 300888 309451 303652 94197 361697 293456 102555167 246117 291990 116666 362599 79120 309144 100363782 81754 304978 64558 309010 84599 65134 360709 361705 361577 50993 100912115 60355 500251 100910557 363858 680465 306264 56042 89868 690252 64154 171049 690961 362162 54350 64351 360611 29631 140673 361502 363136 100360302 315345 100909916 192243 29183 503165 58842 94189 24827 297428 317580 366896 292886 501550 292074 360968 309678 365372 290659 287276 287110 266688 362237 313234 311911 361227 499768 56082 246294 100126191 360426 289350 365191 362504 29167 114113 100359937 64670 367038 294324 81655 362466 367304 29564 83572 290798 360785 84428 116659 361916 140734 308961 364419 292090 24653 360827 299850 282834 302671 29663 79214 679886 64862 58974 302470 287873 306117 81756 363720 360937 81757 117103 288669 64678 54225 65046 317576 60443 25238 682507 84018 124461 313413 310839 192348 500244 314641 79121 60465 25710 311880 309129 313409 25490 60668 306570 246310 24803 361244 29491 24805 29448 317396 60564 85238 25716 287427 79128 116561 24197 116563 64189 83800 140694 25751 81732 24176 192154 192152 300678 303251 25319 29292 84357 25108 116500 64159 363266 314349 308578 117028 117106 683687 266606 89816 300438 81659 140670 290639 297518 361120 25387 25531 312689 364033 83730 29528 64566 24825 25388 312694 85491 25151 361632 81917 100359675 54241 500564 311030 81645 100909548 116743 25407 498798 81637 85256 25423 315840 94193 24221 252929 290635 308178 362118 687208 297995 292925 100910929 288659 290775 362044 309159 292640 290851 171529 287624 681059 314473 171304 315131 140932 304290 360953 690073 289820 290627 689955 310746 65165 302290 114023 291464 311404 295217 288785 689256 84392 360515 641528 314906 680476 84393 289168 309969 296284 363476 84391 362609 296199 362186 25306 293502 300147 29662 83576 294900 317630 364183 362502 85248 360834 287645 315298 315740 289312 24329 60445 29211 24855 289257 360854 307039 310710 64516 84379 24185 64462 316130 305614 304343 500985 287367 363283 312710 64156 314393 261736 363273 81803 50522 24392 292994 83805 681260 690407 313493 500906 309306 60562 116691 310526 116693 116692 116639 315668 299258 308821 498837 29584 365793 394266 266706 100912032 360915 54226 79434 313017 29753 25576 298795 56011 56010 295461 25577 81504 312257 93646 306229 691042 290746 103689930 114638 252916 361987 311494 299799 315999 360797 171452 315756 304555 287275 315055 314013 365042 316017 25530 207119 308942 310843 291750 363235 311913 314397 289051 294709 362983 308944 24932 360768 361459 366618 304344 100911794 81830 685144 100362547 366311 171575 58817 297522 363059 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%R-RNO-2151201.1 Transcriptional activation of mitochondrial biogenesis 361596 24244 306840 83474 24787 311569 304539 363735 293615 499883 24399 25309 25050 24242 100363500 81646 100363502 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME%R-RNO-76044.1 Post-Elongation Processing of the Transcript 116697 687711 288701 314417 680737 171365 311166 313449 689116 361814 29667 291877 307524 308335 690303 309338 295284 100360682 362612 361605 501688 366468 313620 361542 362687 292884 681062 315170 290519 361990 287113 303057 361859 89827 298075 360845 362819 679894 305714 313308 360972 302729 689890 683927 299256 114612 500378 79227 291797 298916 292683 304277 494445 292007 687575 366952 681031 688288 311670 365407 362264 298385 687679 OPSINS%REACTOME%R-RNO-419771.1 Opsins 192223 81644 89810 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME DATABASE ID RELEASE 60%9438460 Role of LAT2 NTAL LAB on calcium mobilization 114851 366508 83571 24628 24629 317676 314641 361696 294048 64545 102552659 84482 24954 64030 50686 79240 24506 24505 294235 56718 84027 117281 24446 294515 365367 29376 59265 690919 112400 24337 24329 310131 309361 140607 81646 103694903 246273 64022 296648 64226 25267 29741 309179 29496 85243 83805 24855 361992 81745 302415 691318 25266 58918 60427 24672 24673 365865 292887 314856 309419 116590 84477 79114 81504 170633 50689 25513 89812 170700 313845 54250 25443 25444 170579 314850 25317 170583 29348 29349 84489 361388 25114 25022 29368 116499 25622 100363500 60662 85385 170582 25155 66017 25156 60464 25233 312754 24185 50557 432361 56822 25408 25660 81515 29414 25467 315648 299147 25150 59323 59325 25433 FRUCTOSE METABOLISM%REACTOME%R-RNO-5652084.1 Fructose metabolism 24190 361730 25659 24788 684314 24192 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%R-RNO-177504.1 Retrograde neurotrophin signalling 81637 308578 310738 65046 171574 140670 24225 81737 25730 116563 83800 140694 25751 29613 54241 25054 59109 300078 294376 116743 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 60%9438576 Rap1 signalling 313644 361710 361714 252857 303298 56011 29434 295347 293508 59326 24703 25636 171337 TCR SIGNALING%REACTOME DATABASE ID RELEASE 60%9438480 TCR signaling 291983 303024 289924 25493 315707 29645 289990 308267 25710 58854 29425 64156 296390 29675 50522 29671 29670 24968 24967 25581 29666 117263 117262 364814 290206 309361 85420 309165 161475 84351 300678 83499 309621 29741 25300 363577 29614 315609 309622 85243 689852 303353 681260 294269 499537 29668 81745 300955 100910488 292766 688090 155918 24981 317371 294270 310727 365388 81827 498837 116725 100912032 29431 29433 94198 29630 81511 296651 408248 361831 307821 29432 25513 83806 287670 313121 679539 100910732 25738 361765 311245 85492 100910771 29669 24932 295338 54259 50557 100912618 287716 362356 29677 29672 287772 83477 287280 287984 311078 309295 81736 TERMINAL PATHWAY OF COMPLEMENT%REACTOME%R-RNO-166665.1 Terminal pathway of complement 24854 298288 24237 296545 362119 313421 VXPX CARGO-TARGETING TO CILIUM%REACTOME%R-RNO-5620916.1 VxPx cargo-targeting to cilium 85258 64632 252881 60627 24650 171455 116654 117103 103690077 309451 81830 305287 25411 83686 79120 50556 245709 100911734 PRPP BIOSYNTHESIS%REACTOME%R-RNO-73843.1 PRPP biosynthesis 29562 DUAL INCISION IN TC-NER%REACTOME DATABASE ID RELEASE 60%9439230 Dual incision in TC-NER 361181 171150 289561 294693 116468 497967 288003 103690054 245976 298508 364834 361365 25737 84389 64156 292778 690966 289758 301382 59102 308415 288651 50522 691642 502227 362394 246216 314061 117017 89809 83503 298074 360471 291703 362479 681260 498109 100361574 304528 366163 64470 100911295 292673 59294 363633 300084 287524 310071 498837 266713 361698 100912032 296883 306274 360704 100912534 294236 302502 288414 498453 361580 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%R-RNO-202427.1 Phosphorylation of CD3 and TCR zeta chains 309621 25300 315609 309622 24932 315707 295338 29645 25710 294269 688090 24981 300678 294270 DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 60%9438578 Dopamine Neurotransmitter Release Cycle 60377 60442 83589 85327 LIPOPROTEIN METABOLISM%REACTOME%R-RNO-174824.1 Lipoprotein metabolism 81637 54225 65046 25506 306825 116563 287276 83800 25073 54281 85264 25081 85253 314459 64474 80848 360495 100361444 291437 296371 362850 24530 292697 24539 25728 83470 293508 25649 25636 300027 298296 25292 100910181 308578 24538 680551 266732 25055 499264 310900 58852 313210 303796 81782 266770 300438 58851 100911545 140670 294930 116548 25507 25696 24153 54241 500564 ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-RNO-8866907.1 Activation of the TFAP2 (AP-2) family of transcription factors 299810 114491 306862 114490 362280 301285 54244 CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME DATABASE ID RELEASE 60%9438173 Conjugation of benzoate with glycine 246263 293779 361638 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 60%9437954 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 116550 171150 103695118 288533 289561 294693 81673 291773 682902 316123 294018 83828 293345 103690054 310784 171152 100360100 364834 306516 361365 303918 83830 498109 81674 100361574 84389 292778 690966 307485 170844 308415 288651 363633 502227 266713 117017 117526 83503 100912534 294236 361580 291703 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%R-RNO-442742.1 CREB phosphorylation through the activation of Ras 24245 24244 83613 116590 81771 24246 361568 317203 501560 81745 24408 29495 24410 24412 192213 293621 246150 117269 25400 100363500 24242 291245 171140 81646 24703 WNT MEDIATED ACTIVATION OF DVL%REACTOME DATABASE ID RELEASE 60%9438496 WNT mediated activation of DVL 309419 83721 58822 307641 116549 81650 303251 303811 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 60%9438806 Presynaptic nicotinic acetylcholine receptors 170945 25102 25101 171131 25590 29422 54240 25103 81721 54239 79557 ACTIVATION OF GABAB RECEPTORS%REACTOME%R-RNO-991365.1 Activation of GABAB receptors 29712 29713 170847 25743 24400 117052 83633 116560 25686 54223 81664 60449 81667 25643 81657 25289 305509 114120 64532 116649 50599 114118 64508 114119 84420 114117 79218 286924 690825 24611 680149 302950 245986 29241 29719 SIGNAL TRANSDUCTION BY L1%REACTOME DATABASE ID RELEASE 60%9438027 Signal transduction by L1 58960 246331 116590 29302 685269 81650 24329 29431 296603 50687 79114 307641 116549 50689 363875 24586 BASE EXCISION REPAIR%REACTOME%R-RNO-73884.1 Base Excision Repair 29240 362600 315344 116468 29541 308576 114521 288003 367090 81528 83507 84490 305957 680915 304577 24561 79116 303369 170841 25737 304528 289758 59102 59294 287524 361698 89809 296883 84495 288414 25591 81513 100911727 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME DATABASE ID RELEASE 60%9438091 Activation of caspases through apoptosome-mediated cleavage 25309 64026 25402 100363502 78963 58918 TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 60%9438398 Transport of connexons to the plasma membrane 394266 24392 MITOTIC METAPHASE AND ANAPHASE%REACTOME DATABASE ID RELEASE 60%9438196 Mitotic Metaphase and Anaphase 291983 289924 304740 289990 292263 58854 29425 64156 499933 117281 304218 314949 29675 50522 29671 29670 24968 25581 24967 29666 117263 117262 364814 290206 103694903 63996 290577 29486 161475 305343 313304 315958 83499 294429 299706 309179 29614 292085 689852 303353 85252 681260 287830 29668 116555 292766 691318 683983 81738 24672 365388 81827 24673 297176 498837 296368 360643 498030 100912032 305420 293155 94198 29630 296651 408248 171576 290875 361389 64515 680006 296558 291689 366381 311412 100360936 361831 117104 304490 361662 307821 83806 301701 287670 298594 286993 308443 100911204 362548 500545 114592 362965 293733 681050 317252 64041 684439 85492 294712 304951 304477 65201 25437 298850 114087 501706 312754 287598 60374 363028 363174 362779 29669 362044 691493 289150 315330 171529 305270 287624 64193 83572 361416 24669 315164 295661 684771 287716 311191 291441 681185 25448 316425 363481 29677 296137 29672 257649 83836 257644 287772 114764 315648 299147 287984 170845 29648 307805 311078 498310 114514 311327 84391 362186 306464 360886 297522 303037 363059 SULFIDE OXIDATION TO SULFATE%REACTOME%R-RNO-1614517.1 Sulfide oxidation to sulfate 691966 81805 292710 25274 170943 ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME DATABASE ID RELEASE 60%9438616 Enzymatic degradation of dopamine by COMT 24267 308868 29253 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME DATABASE ID RELEASE 60%9438546 Autodegradation of the E3 ubiquitin ligase COP1 291983 100910954 289924 29614 29669 689852 289990 303353 58854 681260 360860 307821 287716 29425 29668 64156 292766 83806 29677 287670 29675 29672 50522 365388 29671 81827 29670 498837 24968 25581 24967 287772 100912032 29666 287984 117263 311078 117262 364814 94198 290206 29630 296651 161475 408248 85492 300711 83499 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME%R-RNO-383280.1 Nuclear Receptor transcription pathway 245980 24831 83574 300807 293701 252917 58839 117274 100363472 24706 360896 24705 619579 499670 309288 361128 65035 58850 58853 83826 50659 60349 25154 25149 79240 25664 58852 54278 25682 25747 58851 365744 252924 362125 81808 24890 24873 25735 259241 299210 25271 685072 81812 497991 60351 684085 84385 100365683 EICOSANOIDS%REACTOME DATABASE ID RELEASE 60%9437987 Eicosanoids 56266 299566 286904 503122 25527 290623 24886 DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME DATABASE ID RELEASE 60%9438363 Downstream signaling of activated FGFR4 79114 81504 170633 25513 170700 313845 54250 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 361388 25114 25738 25022 29368 116499 25622 60662 85385 170582 24525 66017 60464 TRANSPORT OF SMALL MOLECULES%REACTOME%R-RNO-382551.1 Transport of small molecules 171148 64076 100911721 363103 289924 155205 291733 171144 171147 140447 140448 25550 25552 311651 170580 366251 266767 24782 24781 305846 287478 83612 84487 24780 310625 116509 314637 25548 290959 365398 171135 170573 363115 170567 305540 50719 317170 113918 25648 298340 294255 501103 24785 116726 25027 689064 24783 170566 24784 84484 289459 29504 25139 29502 29509 170698 25658 25073 29501 310392 302863 314396 24904 24778 24779 29715 85253 310808 58976 308028 170667 313139 114629 295417 64018 100360087 306866 252919 117267 100158233 117261 282712 29440 298280 316519 29642 79213 303353 311204 294281 79212 84550 84551 295645 83470 65039 683667 299903 94106 89776 170943 64554 295455 58978 85426 664630 296600 64846 297386 89821 365388 303565 89823 171373 361586 171384 140860 117955 25065 501925 50662 25059 58980 24546 291582 25351 366432 366441 252854 192208 289353 94198 308069 288499 192215 303205 295245 266612 65194 25693 300051 312192 317599 367086 79430 63866 24400 24767 293874 24768 311287 116477 301111 192675 60449 297566 81667 689779 171497 171498 171496 117596 58950 282822 297797 116469 291969 60395 308022 288026 79425 497948 296981 140933 29693 294962 309407 304315 83579 84494 63847 114246 292168 29600 362645 66026 365391 25688 24941 288371 362247 297932 312896 499287 63848 83810 116455 29503 29639 317420 25749 24898 295041 366545 29232 116831 289407 29233 291555 362802 286920 299714 266730 314401 363516 94170 84356 287276 302973 685232 155192 303856 25559 85264 292597 25391 81642 300664 499474 24891 306811 360932 310836 293735 140669 25390 25303 25081 362053 314459 296302 64474 80848 299027 54318 64678 54225 65046 363024 25490 29699 24679 690825 100912034 680149 25581 245986 29241 29708 65187 29709 29707 116563 83800 25674 24947 25319 29292 140675 79239 58963 25108 29695 65197 315272 170699 79246 25451 287715 365946 29705 308016 289606 29694 368044 192258 64190 294141 25456 100912455 25450 292697 24539 25728 116967 299159 25649 300027 64672 685152 308578 367318 63882 679958 60586 24217 313210 303796 25122 300438 24215 24218 140670 24213 24216 293650 24211 24214 79123 24212 116664 29598 689560 170496 29599 24825 309139 290673 171028 25650 436582 309135 54241 295586 500564 29132 100361584 59299 83615 299971 307811 29485 81637 306009 140915 80878 85256 311387 25362 246239 294321 83529 103694857 246235 83629 691209 353307 292657 25715 83511 29735 287532 25634 432363 80899 83509 116642 170840 503568 246234 65202 65200 500820 117152 65207 83806 29484 29483 365962 117100 287670 293048 84608 50676 298786 80900 117240 114518 315439 50572 297910 114613 314441 363985 680602 304785 304784 63997 360539 64522 171163 24221 294698 29464 498185 84012 301010 361986 500973 84511 309111 685451 29669 25521 64199 25289 25725 114120 29757 64532 294329 114118 293508 114119 114117 25636 79218 298296 29677 311839 140944 24538 311168 81826 266732 29672 25055 29726 499264 60423 54302 58852 296969 81782 315311 266770 25246 58851 100911545 24385 287772 294930 362861 116638 94172 259248 287984 24268 311078 25696 29323 54301 24153 100134871 681896 54300 100911440 291983 289990 58854 29425 29675 29671 29670 24968 24967 29666 117263 117262 364814 290206 29517 161475 24703 83499 298203 24245 24244 296588 171433 353231 29614 64198 114766 364601 307350 689852 100910779 301418 294560 291470 365567 295462 114217 24246 50655 683955 295669 305142 305886 289453 29668 312382 64831 292766 81827 24242 29630 296651 408248 307821 361619 85492 116643 288562 29199 287716 65054 29171 25293 29170 25480 25241 25240 25400 25344 171140 24451 54223 287167 365345 305509 64156 64508 54231 84420 310218 25632 304805 689035 50522 25294 289443 25230 311846 79032 362642 305135 64673 54281 114506 290783 53372 308668 304203 294429 300259 299706 292085 117021 360495 304862 100361444 291437 296371 24170 362850 24530 58958 24171 245922 361069 113929 65274 681260 287830 116555 362281 25281 683983 295692 291874 81738 499974 113975 303638 498837 25560 360967 114628 100912032 25497 362335 24646 116721 286970 25270 407784 116548 83535 25507 170913 362912 293939 85493 314537 297930 63886 290823 299609 170924 83519 314352 25506 170551 302422 289874 362891 308003 25132 306825 303333 305424 81830 362356 25292 100910181 680551 310900 302950 287280 REGULATION OF NECROPTOTIC CELL DEATH%REACTOME DATABASE ID RELEASE 60%9439094 Regulation of necroptotic cell death 306886 78971 266610 246775 25385 246097 117279 311786 246756 60371 64044 NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME%R-RNO-5654727.1 Negative regulation of FGFR2 signaling 116590 500985 306141 500526 83805 681260 64156 81504 170633 50689 170700 117281 54250 25443 25444 170579 50522 24672 24673 314850 498837 25317 170583 29348 29349 100912032 25022 29368 116499 25622 60662 103694903 66017 60464 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 60%9438572 GABA synthesis, release, reuptake and degradation 64832 689955 24380 50676 24379 116470 25531 84556 79213 25558 79130 79212 83612 171163 24803 81632 25716 291133 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME%R-RNO-69300.1 Removal of licensing factors from origins 291983 24708 114851 83571 289924 289990 58854 307821 362304 29425 301430 64156 316273 295596 83806 287670 29675 295052 50522 29671 29670 24968 24967 25581 29666 117263 117262 364814 290206 362817 161475 85492 114494 83499 29614 29669 689852 303353 681260 287716 29668 292766 314642 29677 29672 313138 296178 365388 29728 81827 291927 307126 498837 360621 312538 287772 291137 313479 100912032 29685 292071 291885 288532 287984 311078 94198 29630 296651 408248 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME%R-RNO-112315.1 Transmission across Chemical Synapses 24957 65046 116470 83633 54223 25550 81771 83612 305509 24408 24803 64508 24410 84420 24412 58942 25716 64832 170567 362876 293645 64830 690825 680149 24681 140592 140591 245986 84556 29241 29708 65187 29709 29707 116563 81646 24947 24703 29719 25297 24245 140675 24244 290567 29695 60442 25451 29705 289606 140724 29694 140725 192258 25450 29642 24246 79213 24680 140729 79212 84347 81745 29495 29422 54240 100911769 85426 84591 308578 24611 140670 25531 84016 59317 366432 24242 291245 81632 497009 85327 291133 314856 29712 81637 29713 170847 25743 24400 117052 116590 116560 25686 81664 60449 81667 25643 81657 29629 29627 361568 60355 29628 25050 317203 29559 60341 54257 116649 50599 83817 29253 29539 286924 29483 29503 315840 25553 24267 308868 24898 50676 293621 257648 100363500 171163 25023 84012 58948 83613 25252 83589 287609 24407 298521 553106 170945 25102 60377 171026 54234 25289 25558 501560 116600 114120 64532 25101 114118 171131 25590 293508 25302 56064 114119 65024 114117 25103 81721 54239 79218 79557 29322 689955 24654 24380 24379 192213 302950 246150 116638 117269 25400 79130 171140 50688 METABOLISM OF NITRIC OXIDE%REACTOME DATABASE ID RELEASE 60%9438499 Metabolism of nitric oxide 24244 171128 25514 24185 682507 25523 24600 298184 29244 29498 29270 311111 64157 24242 297402 292894 25751 294239 25404 170520 299331 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 60%9439098 Negative regulation of TCF-dependent signaling by WNT ligand antagonists 80722 100912050 287102 293897 312781 TRANSLESION SYNTHESIS BY POLI%REACTOME%R-RNO-5656121.1 Translesion synthesis by POLI 316344 313702 50522 116468 287524 309812 288003 498837 100912032 89809 296883 681260 25737 291526 64156 304528 288414 59102 MET ACTIVATES RAP1 AND RAC1%REACTOME DATABASE ID RELEASE 60%9439314 MET activates RAP1 and RAC1 24446 63881 287942 54245 81504 363875 361388 313388 295347 171337 100911248 DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME DATABASE ID RELEASE 60%9438353 Downstream signaling of activated FGFR1 499308 299236 79114 81504 170633 25513 170700 313845 54250 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 361388 25114 25738 25022 29368 116499 25622 60662 85385 170582 24525 66017 60464 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%R-RNO-3065678.1 SUMO is transferred from E1 to E2 (UBE2I, UBC9) 25573 308384 301442 65026 308508 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%R-RNO-174437.1 Removal of the Flap Intermediate from the C-strand 296883 59294 25737 287524 289758 361698 84490 59102 361836 SYNTHESIS OF CL%REACTOME%R-RNO-1483076.1 Synthesis of CL 366196 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 60%9438371 Signalling to p38 via RIT and RIN 291983 171109 24514 246145 289924 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 58854 102552659 170668 29425 65179 24408 25167 64030 59109 24716 24410 24412 117281 24446 498576 29675 29671 29670 29376 24968 24967 29372 690919 25704 112400 29666 24337 24329 117263 117262 116663 364814 290206 24592 103694903 64022 161475 360814 24703 83499 24245 24244 25267 309179 29614 29496 295234 29211 689852 64363 24497 652957 116630 140924 114103 24246 303353 289257 84423 84422 29668 29495 25614 292766 691318 25266 362572 360573 60427 24672 309168 365388 81827 24673 288924 171081 24242 94198 291245 296072 29630 81511 296651 408248 304893 24586 25746 116590 307821 50689 85492 83613 312754 300980 66023 25525 25326 314612 305203 312664 25136 432361 287716 114858 58960 192126 29542 192213 25467 192117 364052 246150 315648 305614 299147 288589 25400 25150 59323 25344 171140 29622 84598 29613 170577 25054 59325 25433 25676 291713 310533 64156 50522 25581 89807 310738 89804 83805 681260 64159 498837 100912032 362045 56011 79114 81504 170633 83806 170700 313845 54250 287670 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 25114 25022 29368 116499 60662 85385 170582 24525 66017 60464 29669 24225 81737 25730 29677 29672 287772 287984 311078 ERKS ARE INACTIVATED%REACTOME DATABASE ID RELEASE 60%9438484 ERKs are inactivated 24672 116590 24673 100912585 361565 300980 315648 114509 116663 103694903 498003 50689 60587 117281 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 60%9438710 Synthesis, secretion, and deacylation of Ghrelin 59301 24391 266758 24952 680782 25608 24482 306515 293142 65036 25204 301265 65166 24506 24505 IRAK1 RECRUITS IKK COMPLEX%REACTOME%R-RNO-937039.1 IRAK1 recruits IKK complex 363520 100912618 305835 309361 309295 679539 296390 311245 305549 84351 116725 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 60%9438701 Adherens junctions interactions 307505 83502 81679 308417 29163 307618 497229 360687 84407 288124 498515 311163 25066 29162 26955 192183 361432 192248 117048 25409 498281 29181 116777 360882 83501 ECM PROTEOGLYCANS%REACTOME DATABASE ID RELEASE 60%9439039 ECM proteoglycans 297894 24791 25304 81008 499271 25567 58982 25592 25181 29302 24477 311061 685269 25254 364786 296358 29139 25312 114122 25393 29169 24617 EUKARYOTIC TRANSLATION TERMINATION%REACTOME%R-RNO-72764.1 Eukaryotic Translation Termination 307503 293700 288309 501582 24206 24420 100911685 SPERM:OOCYTE MEMBRANE BINDING%REACTOME DATABASE ID RELEASE 60%9438919 Sperm:Oocyte Membrane Binding 24936 499152 RET SIGNALING%REACTOME DATABASE ID RELEASE 60%9439189 RET signaling 291983 171109 24514 246145 289924 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 58854 102552659 170668 29425 65179 24408 25167 64030 24716 24410 24412 361364 117281 24446 498576 29675 29671 29670 286908 29376 24968 24967 29372 690919 498898 25704 112400 29666 502694 24337 24329 117263 117262 116663 364814 290206 24592 103694903 64022 161475 360814 24703 83499 24245 24244 313644 25267 309179 29614 29496 295234 29211 689852 64363 24497 652957 116630 140924 114103 24246 303353 289257 84423 84422 29668 29495 25614 292766 691318 25266 362572 360573 60427 24672 309168 365388 81827 24673 288924 171081 24242 94198 291245 296072 29630 81511 296651 408248 304893 24586 25746 116590 307821 312477 50689 85492 83613 312754 300980 66023 25525 25326 314612 305203 312664 25136 432361 287716 114858 58960 192126 29542 192213 25467 192117 364052 246150 315648 305614 299147 288589 25400 25150 59323 25344 171140 84598 170577 59325 25433 25676 310533 366508 64156 50522 100912585 25581 114509 290361 89807 89804 84427 85243 83805 24680 681260 64159 498837 100912032 362045 56011 84477 79114 81504 170633 25513 83806 170700 313845 54250 287670 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 361388 25114 25738 25022 29368 116499 25622 60662 85385 170582 24525 66017 60464 498416 29669 29677 29672 287772 287984 311078 PYROPHOSPHATE HYDROLYSIS%REACTOME%R-RNO-71737.1 Pyrophosphate hydrolysis 294504 310856 361842 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 60%9437794 Cyclin D associated events in G1 24708 171150 114483 114851 83571 24514 399489 100909750 311562 682033 291105 117104 83805 681260 84389 311860 64156 81758 684111 94201 362356 499655 294790 54238 25164 117281 300947 81515 24672 50522 24673 680111 498837 266713 315648 287280 100912032 366275 103694903 100360427 361178 58919 116651 LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME DATABASE ID RELEASE 60%9437923 Ligand-dependent caspase activation 306886 266610 246775 25385 246097 117279 311786 246756 64044 SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME DATABASE ID RELEASE 60%9438716 Small interfering RNA (siRNA) biogenesis 311130 363006 299284 59117 ABACAVIR METABOLISM%REACTOME%R-RNO-2161541.1 Abacavir metabolism 24172 362282 311352 100363253 310903 PROTEIN FOLDING%REACTOME%R-RNO-391251.1 Protein folding 299809 24400 288620 50664 297406 25686 81664 60449 81667 25643 295230 24818 690155 365901 363143 25740 29481 294864 29374 294962 83579 64013 307641 116549 54296 286924 81650 288305 VITAMIN C (ASCORBATE) METABOLISM%REACTOME DATABASE ID RELEASE 60%9438472 Vitamin C (ascorbate) metabolism 50622 50621 25035 64001 103690044 24778 309465 PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME%R-RNO-5576894.1 Phase 1 - inactivation of fast Na+ channels 65195 259243 56817 100911951 65199 116695 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 60%9437875 Creatine metabolism 29593 25257 24264 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 60%9437887 Metabolism of proteins 289924 252902 25369 24590 24206 24591 63880 299314 50692 316033 29237 100911615 302705 89842 303353 25329 367308 304966 365388 29142 24390 94198 116700 24664 314856 304798 100910954 103692785 140655 362952 287417 360572 292964 367865 103690821 100912571 367265 100910180 294282 363519 116636 29236 100360647 100911575 360853 140662 100364265 306257 26295 100360841 29545 103690015 684988 313922 691531 315723 65138 295975 303753 140661 24890 64640 29283 56783 29284 103692831 28298 287276 287436 100360679 26962 64302 302697 103693375 290641 689284 362041 192234 295660 300253 100360117 296709 103694404 117019 296302 317646 29288 81767 29282 81763 100360522 81768 81765 81769 50557 64205 288599 311120 301299 100362830 292148 690468 314652 81775 293427 81770 305291 29752 64638 81776 292762 299027 25348 300069 306079 103694169 293484 288516 65139 297756 64514 100912182 300079 171145 298700 117045 25347 682793 100910370 685963 124440 306926 691947 687780 29258 54318 100911110 100359922 161477 65043 25538 499782 100361079 303831 299809 361676 29565 287427 25581 24197 171361 308755 25728 64159 288001 25649 300027 25531 288702 100359675 84491 25407 288305 59301 362859 25227 25423 117152 83806 287670 290257 81506 81650 252929 29669 24232 81726 29677 689955 29672 297173 114023 287772 25653 287984 311078 100365043 295274 171101 297593 295686 100910200 313216 680403 100362554 293184 24829 100912338 298317 25447 308282 103690891 299602 305268 689226 296956 361247 300837 64631 103694506 29597 100909787 297337 366169 306969 294331 25040 64647 680312 498560 100909597 266712 296360 316400 295052 115771 353304 116718 289623 293561 295543 303277 300046 103691942 64345 64525 81807 24874 29560 114494 361258 29452 499766 24903 266758 680782 498012 24310 290963 25121 306515 293142 24715 65036 301265 54242 65166 309533 25669 64557 497672 117553 114122 25661 361969 24367 684797 680424 100909445 83477 100364835 307029 295568 306945 363065 363064 29534 100359692 303478 292588 314432 362412 361531 312703 360847 291157 361181 304832 304343 301442 287367 363283 312710 500225 25737 64156 261736 103692172 363273 361107 361286 25641 293494 116650 287927 314799 50522 245977 29357 246326 24773 81822 680036 29447 291685 690345 363707 297893 494021 79438 25662 192155 361509 298012 299872 363445 100360057 367195 25631 100360619 100911847 81920 81729 54281 498351 360471 300222 60575 296084 680415 313262 315523 24919 25591 316583 65196 288752 313536 305571 362924 100911750 290638 363040 681260 312560 84576 29591 641452 103690035 64470 300084 287524 310071 29316 498837 361925 116725 100912032 100362121 360915 65137 291737 64442 494342 362275 302502 303923 316440 24179 64445 304023 499417 84593 293667 295461 100359528 288921 313722 366854 310363 303336 363083 100360914 300849 171043 500587 170583 93646 85273 308283 678726 301674 306129 311881 313782 313101 292757 287275 303215 140593 498941 300724 117524 310843 100125363 307404 309444 362081 361907 29204 498959 303631 362511 301015 103690047 312504 362409 305424 494223 308999 685144 360818 363790 304522 58817 361354 309453 192351 24800 360800 361029 297522 316642 365619 310326 117185 363103 25473 59107 304135 116635 83727 25353 25548 24506 24505 117036 25312 445442 298941 85253 313139 366061 24391 311204 25533 291615 24233 58983 24942 25296 299903 301012 289994 310411 25627 171121 300674 361407 361207 100910318 299075 361073 300888 81519 309451 94273 303652 29582 140568 293456 102555167 246117 291990 116666 362599 79120 309144 100363782 81754 304978 25547 309010 24400 84599 288620 65134 360709 50664 361705 297406 294410 25686 81664 432392 60449 308511 81667 140808 65271 25643 295230 361577 100912115 24818 690155 362625 365901 60355 363143 500251 25740 100910557 29481 363858 294864 680465 306264 29374 56042 294962 89868 83579 64013 690252 307641 64154 116549 171049 54296 690961 362162 303100 54350 286924 64351 360611 29631 140673 361502 25478 363136 100360302 315345 100909916 192243 25197 29183 503165 58842 94189 24827 297428 308757 501550 292074 309678 290659 302973 362237 367252 295319 56082 100126191 25081 295394 303016 362504 298452 29167 287523 680594 362191 300033 363241 81655 29564 314638 290798 298400 84428 29144 304962 29702 116659 140734 308961 292090 299850 79214 293725 305073 302470 266607 81756 363104 117103 81750 64312 406161 58935 103689965 296121 84478 171329 54225 501659 304150 85471 290864 310960 311807 288482 289717 308669 309595 360860 290631 25490 316794 306570 246310 287444 314644 288923 310261 171102 294790 290997 362704 303539 308896 314453 302488 314949 100910107 297989 100912059 298247 60371 360819 307905 313427 117519 310306 24952 291796 292876 78971 291095 293587 361381 307848 361373 300036 315134 362414 304579 100361658 293570 63996 266601 114558 24176 29486 60331 192152 312688 310935 303201 362636 100911225 313304 315958 303351 687696 408217 309512 361015 688466 298068 171565 288919 363084 311856 361190 302415 100190936 499801 309153 363164 290794 312937 689730 361273 309858 498013 80881 689134 80843 294912 287362 24825 25388 311030 498798 296290 84577 309995 501145 313961 297561 25094 298786 299957 64520 500545 316164 114592 83422 362965 367152 293733 29251 315713 287662 293967 362827 361645 24504 29200 64549 83614 64550 499179 64041 294698 25204 362280 363287 114031 685451 29417 298296 294075 302813 296099 289468 311786 65165 25253 24268 25608 114489 171562 116510 364398 291983 289560 171154 24765 296304 500367 24946 84430 308440 680076 25434 294241 289990 315745 290692 54279 362934 303635 58854 293721 117522 313488 499016 29425 170818 100910410 116658 300060 79112 300950 300948 305895 315108 79110 300017 64202 300025 296627 63878 287983 29750 29675 503446 685860 29671 541462 29670 362862 363464 503164 691259 60378 24968 680210 24967 303792 300772 192263 690914 305792 29666 306073 316131 308807 117263 363455 117262 171129 100911548 364814 362031 299266 290206 56646 65044 292845 299208 312806 161475 310982 309686 311039 302931 311836 83499 83501 305235 24244 499751 365277 689197 102553119 29614 305626 313348 29211 59302 310856 689852 29403 415062 361664 652957 289831 291212 361268 338474 362547 313878 289257 304920 293129 499972 362762 29668 100911374 360622 498992 304917 64456 292766 362756 102554393 25685 297592 310670 289085 304571 313445 25277 304334 25295 84019 81827 367083 303602 304794 25285 296368 360838 117537 367785 293719 100360475 315075 24482 360475 317381 295382 171081 690037 24242 366478 363259 314273 29630 363060 100909521 296651 100909524 408248 314457 688993 688673 24483 363284 361187 64366 295051 498272 25373 298541 83505 298071 293345 171152 307821 310710 302972 311847 502017 312826 29758 25615 296394 296076 114711 311530 302915 296370 29640 304860 300741 297393 303692 81759 300089 304543 25280 294400 296624 360518 299346 304954 407765 407764 498486 287920 85492 301155 297417 116643 116696 501167 364901 363109 362415 100910143 361368 361634 315000 316628 313770 303311 291132 64462 287054 313743 364050 116597 302981 85237 290279 287706 313233 302288 313231 287716 364032 306608 289181 288309 313020 60333 315807 289525 687364 313242 315222 305351 681194 302499 302526 499260 292485 313038 305614 362581 309626 304850 117044 303730 303731 116484 78965 501403 310258 316614 24177 307151 312690 362093 64632 303024 252881 60627 171455 25493 116654 89820 500616 298534 24498 83712 89829 305451 293700 102551184 53372 361842 294429 29240 300259 303874 299706 680097 114521 292085 117021 304862 24420 295277 100912489 100911685 364723 58958 245922 113929 307503 65274 287830 501582 25573 102548682 116555 103689978 308384 362281 78973 65026 25281 300193 100360950 683983 308508 295692 679900 500351 291874 81738 499974 679983 113975 360967 102557184 25497 362335 407784 362912 305287 50556 245709 100911734 54226 100361647 362133 79434 300445 64515 315287 314352 315879 307893 79224 25506 688813 114589 79210 311202 25586 303743 361831 64043 353227 362567 362566 24571 311169 103694910 360928 65158 291912 500262 286976 311633 362902 364227 113910 362891 353251 83725 84595 303702 288038 498005 29160 361749 288041 313121 691120 103694000 207126 500133 297504 362182 24259 498034 303886 294862 316228 207113 100909827 252916 307200 303244 685758 24210 298692 361765 81716 298683 260320 316976 315139 311245 306549 60373 287159 83627 288238 502308 83681 100910771 683206 24175 81830 689404 314855 25083 362356 54237 309035 292905 316091 500221 378774 83476 302666 300668 315212 171459 315405 309051 307838 116740 287280 300339 293060 81686 25376 24832 294504 306886 300653 293705 292124 500572 292325 690512 309295 293023 303755 690367 29461 363982 301013 100360606 361014 24205 362491 288692 315911 310324 286761 170501 363599 500050 362788 84508 310677 PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME%R-RNO-427975.1 Proton oligopeptide cotransporters 246239 117261 FREE FATTY ACID RECEPTORS%REACTOME DATABASE ID RELEASE 60%9438757 Free fatty acid receptors 292794 292310 266607 365228 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 60%9438905 SHC1 events in ERBB2 signaling 29496 690919 112400 24337 24329 24680 432361 102552659 117255 59323 85385 64022 59325 25433 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%R-RNO-1660514.1 Synthesis of PIPs at the Golgi membrane 116482 317576 309855 81747 307842 65052 114554 116720 361632 64310 305419 364629 114089 316457 363131 KANDUTSCH-RUSSELL PATHWAY%REACTOME%R-RNO-6807062.1 Kandutsch-Russell pathway 117278 64191 298298 114100 GLYCOLYSIS%REACTOME%R-RNO-70171.1 Glycolysis 100364062 24849 117276 287115 100911625 24190 60416 685076 299052 117281 24959 24672 54283 24673 25741 25630 24385 25059 315648 24651 292804 25438 24191 24189 100911725 24640 100362738 103694903 24644 65152 24333 24334 246255 66020 24638 NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 60%9439148 NIK-->noncanonical NF-kB signaling 291983 303024 289924 289990 58854 307821 29425 64156 83806 117553 287670 360640 29675 50522 29671 29670 24968 25581 24967 100360982 29666 361509 117263 117262 364814 309361 290206 361765 161475 85492 83499 29614 29669 689852 303353 681260 287716 29668 292766 362356 29677 29672 365388 81827 309452 498837 287772 100912032 287280 287984 311078 94198 29630 296651 408248 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 60%9437789 DNA strand elongation 307639 499914 59294 116468 287524 288003 361698 85242 84490 301323 290842 292058 246327 89809 361836 296883 25737 304528 289758 288414 59102 81513 100911727 GABA B RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 60%9438293 GABA B receptor activation 29712 29713 170847 25743 24400 117052 83633 116560 25686 54223 81664 60449 81667 25643 81657 25289 305509 114120 64532 116649 50599 114118 64508 114119 84420 114117 79218 286924 690825 24611 680149 302950 245986 29241 29719 NETRIN-1 SIGNALING%REACTOME%R-RNO-373752.1 Netrin-1 signaling 60630 114523 54319 682507 65218 299737 64465 83805 25738 25150 309081 85420 25311 300955 25614 140593 363875 140941 310192 EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME%R-RNO-3928663.1 EPHA-mediated growth cone collapse 298528 310643 312279 84358 94268 297173 246217 81515 171287 60589 25537 83805 25150 83785 25589 79208 316539 25614 29210 366492 24884 362513 81762 299331 GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME%R-RNO-5696399.1 Global Genome Nucleotide Excision Repair (GG-NER) 361181 171150 294693 116468 304343 288003 301442 287367 363283 312710 500225 25737 84389 64156 289758 261736 301382 313098 103692172 59102 363273 361107 308415 288651 293494 287927 50522 310707 81822 502227 300813 89809 298012 298074 300222 296084 315523 24919 25591 291703 681260 312560 304528 64470 292673 59294 300084 287524 498837 266713 361698 361925 116725 100912032 100362121 360915 65137 296883 291737 294236 302502 288414 316440 499417 361580 84593 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 60%9438198 Extension of Telomeres 100362333 299112 59294 116468 304573 287524 288003 361698 85242 84490 301323 246327 89809 361836 301965 296883 25737 304528 289758 288414 59102 81513 100911727 CDO IN MYOGENESIS%REACTOME%R-RNO-375170.1 CDO in myogenesis 307505 50938 689314 100909750 64465 360715 29148 81649 337868 499497 361432 25714 311860 299766 60352 300811 360600 309957 83501 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 60%9438201 Regulation of insulin secretion 29716 24400 25686 81664 60449 81667 294962 83579 306243 29699 24679 24896 690825 100912034 83588 252857 680149 81678 307234 24952 245986 29241 25559 24778 25297 25679 25262 685451 24239 25176 295347 25521 24175 171026 24680 64199 54234 25289 25725 116600 25051 114120 25083 64532 246153 114118 293508 114119 114117 59326 25636 25399 79218 29322 89788 300992 81662 24654 266607 81666 309242 25351 83535 25603 50688 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%R-RNO-174403.1 Glutathione synthesis and recycling 360994 25283 116684 362368 29739 291394 25458 362196 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%R-RNO-1253288.1 Downregulation of ERBB4 signaling 681260 50522 64156 59323 498837 297930 100912032 ACYL CHAIN REMODELLING OF PC%REACTOME%R-RNO-1482788.1 Acyl chain remodelling of PC 360426 690388 313997 691810 691813 29359 362434 24913 289733 24653 314075 29692 298579 362039 691905 361467 100359680 295631 296091 29526 311341 297694 29354 690610 296048 G0 AND EARLY G1%REACTOME%R-RNO-1538133.1 G0 and Early G1 362485 300947 295052 25729 680111 297893 362763 310511 25255 292787 305171 689523 81758 84576 362817 100360427 313048 361178 116651 114494 ACTIVATION OF CAMK IV%REACTOME%R-RNO-442745.1 Activation of CaMK IV 24244 25050 24242 IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME DATABASE ID RELEASE 60%9438775 IL-6-type cytokine receptor ligand interactions 29201 24514 310132 365395 81680 245983 289747 313173 25707 84598 290655 25205 171040 60584 ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME%R-RNO-2395516.1 Electron transport from NADPH to Ferredoxin 313786 79122 29189 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%R-RNO-2032785.1 YAP1- and WWTR1 (TAZ)-stimulated gene expression 304514 363014 308582 361630 295062 GLYCOGEN SYNTHESIS%REACTOME DATABASE ID RELEASE 60%9437826 Glycogen synthesis 114005 50522 498837 309513 81675 289827 100912032 681260 64156 25623 364682 690987 685076 289632 24645 HEME BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 60%9438380 Heme biosynthesis 25374 304024 25709 29421 289219 309391 309070 691853 25748 361338 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 60%9437959 Ubiquitin-dependent degradation of Cyclin D1 291983 289924 29614 29669 689852 289990 303353 58854 681260 307821 287716 29425 29668 64156 94201 292766 83806 29677 287670 29675 29672 50522 365388 29671 81827 29670 24968 498837 25581 24967 287772 100912032 29666 287984 117263 311078 117262 364814 94198 290206 29630 296651 161475 408248 85492 58919 83499 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 60%9437922 Dimerization of procaspase-8 306886 266610 246775 25385 246097 117279 311786 246756 64044 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME DATABASE ID RELEASE 60%9438509 COPII (Coat Protein 2) Mediated Vesicle Transport 81754 309010 84599 65134 360709 361705 60355 295461 363858 680465 306264 56042 89868 310710 690252 64154 25423 171049 54350 29631 140673 361502 287427 100360302 100909916 93646 29183 58842 24827 501550 292074 309678 287276 362237 287275 56082 252929 100126191 310843 64462 685144 58817 302470 301012 289994 65165 171121 100910318 299075 102555167 297522 246117 116666 362599 309144 25407 100363782 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%R-RNO-391160.1 Signal regulatory protein (SIRP) family interactions 499537 25622 29364 100909977 25614 81504 361537 25528 50646 155183 83805 VITAMINS%REACTOME DATABASE ID RELEASE 60%9438525 Vitamins 25279 361631 154985 114700 308190 312495 PHASE II - CONJUGATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 60%9437829 Phase II - Conjugation of compounds 64352 58953 24297 64076 116631 116632 297433 100912430 362368 312952 290401 396552 25355 81869 396551 288617 396527 25331 309465 316153 503103 290681 24267 294103 58962 24912 501103 499688 690050 114846 289827 100910526 29443 64473 300691 24426 24861 681913 246263 499689 360994 29487 293779 25283 301595 289197 292915 293700 116684 361638 83472 303953 24422 24424 24902 154516 81522 306866 29739 117267 25458 171072 298280 100910057 360268 288309 288719 103690044 171347 295443 171341 300983 64305 361510 290947 83783 362196 297029 574523 291394 78959 113992 103689950 140925 367201 683630 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%R-RNO-211227.1 Activation of DNA fragmentation factor 288064 29395 25402 114214 498988 498072 24917 INTERFERON ALPHA BETA SIGNALING%REACTOME DATABASE ID RELEASE 60%9438834 Interferon alpha beta signaling 690894 298205 298211 686326 298210 24481 305896 500491 359726 116689 367264 100911527 288264 361390 24697 502965 100912356 25124 502966 89829 252971 502962 100361294 25622 84598 312688 288774 103690314 100912314 INTERLEUKIN-12 FAMILY SIGNALING%REACTOME%R-RNO-447115.1 Interleukin-12 family signaling 100361294 24514 288905 680609 84598 155140 64546 25205 171334 171333 84405 689932 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME%R-RNO-168142.1 Toll Like Receptor 10 (TLR10) Cascade 303024 116590 25493 689314 363855 314322 81771 308267 363520 64156 291912 498003 296390 50689 25272 117281 314384 313121 287398 50522 500133 100912585 679539 315305 305549 114509 81647 301059 81649 362418 305451 305835 116663 100363500 309361 361765 289014 81646 103694903 309165 315139 311245 84351 114495 100910771 317546 50658 361565 300980 300447 100912399 116596 116667 303200 315994 100912618 681260 501560 116554 24516 362356 81722 287707 24672 309452 24673 498837 315648 117269 116725 100912032 287280 309295 81736 362491 25742 60587 305751 309957 81525 304859 54226 REGULATION OF TP53 DEGRADATION%REACTOME DATABASE ID RELEASE 60%9438465 Regulation of TP53 Degradation 314856 304798 100910954 24185 681260 64156 81745 691318 56718 54237 117281 282844 295052 50522 24672 140926 115771 282845 24673 498837 315648 100912032 310131 103694903 29517 360471 114212 362817 296648 300711 311575 64226 114494 25405 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME%R-RNO-5654228.1 Phospholipase C-mediated cascade; FGFR4 54250 25444 25317 170583 29349 25114 25738 29368 116499 170582 170700 66017 60464 HYDROLYSIS OF LPC%REACTOME%R-RNO-1483115.1 Hydrolysis of LPC 296091 691810 361401 24653 691813 691905 311341 297694 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 60%9438990 Activated NOTCH1 Transmits Signal to the Nucleus 681260 687424 50522 64156 84010 498837 25496 100912032 ALPHA-DEFENSINS%REACTOME DATABASE ID RELEASE 60%9438936 Alpha-defensins 613221 102554637 103690254 408247 498659 308873 25052 613225 24932 683849 286958 286995 362347 24691 MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME DATABASE ID RELEASE 60%9439121 Miscellaneous transport and binding events 24170 24171 361069 25294 289443 25230 116967 287478 311846 79032 362642 305135 64673 114506 290783 308668 304203 HYALURONAN METABOLISM%REACTOME DATABASE ID RELEASE 60%9439014 Hyaluronan metabolism 282821 294673 266805 282580 24782 116721 308797 25406 293186 64468 24434 367166 300757 64152 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME DATABASE ID RELEASE 60%9438751 Zinc influx into cells by the SLC39 gene family 305846 294281 306009 291733 314637 361986 295455 300051 DOPAMINE RECEPTORS%REACTOME%R-RNO-390651.1 Dopamine receptors 29238 24316 25432 25195 24318 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME%R-RNO-446388.1 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 363509 362973 499443 680419 81634 PHOSPHORYLATION OF THE APC C%REACTOME DATABASE ID RELEASE 60%9438321 Phosphorylation of the APC C 25203 290875 361389 296558 296368 291689 360643 366381 498030 311412 100360936 361831 304490 305420 293155 54237 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%R-RNO-1660517.1 Synthesis of PIPs at the late endosome membrane 315422 65052 309855 361632 287607 316457 363131 306490 307842 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 60%9437939 IRS-mediated signalling 291983 26954 171109 24514 246145 289924 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 58854 102552659 170668 29425 65179 24408 25167 64030 64562 287871 24716 24410 24412 56718 117281 24446 301518 498576 29675 298514 29671 29670 29376 24968 24967 29372 690919 25704 112400 29666 24337 24329 117263 117262 116663 364814 290206 24592 103694903 246273 64022 161475 308869 60445 360814 24703 64226 83499 24245 24244 338457 25267 309179 29614 29496 295234 29211 689852 64363 24497 652957 116630 140924 114103 24246 303353 24855 289257 84423 361992 84422 29668 81745 303605 29495 25614 292766 691318 25266 363131 362572 310091 360573 60427 24672 309168 365388 81827 24673 292887 288924 171081 24242 291245 94198 296072 29630 81511 296651 408248 297960 304893 24586 25746 301574 116590 307821 50689 100912571 116636 85492 25233 300253 83613 290291 312754 83803 24185 29516 65248 300980 66023 25525 25326 360776 314612 305203 312664 25136 65052 432361 287716 114858 58960 501146 192126 29542 192213 83840 25467 192117 295357 364052 246150 315648 117045 305614 299147 78975 288589 25400 25150 100909655 117044 59323 25344 171140 84598 170577 117043 59325 25433 25435 25676 310533 64156 50522 25581 89807 29741 89804 85243 83805 681260 64159 100361543 498837 100912032 362045 56011 79114 81504 170633 25513 83806 170700 313845 287670 54250 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 361388 25114 25022 29368 116499 25622 60662 85385 170582 24525 66017 60464 29669 29677 29672 287772 287984 311078 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 60%9438689 Trafficking of AMPA receptors 24245 314856 81637 25252 65046 140724 140725 29629 29627 24246 60355 171026 24680 29628 140729 84347 29495 100911769 84591 315840 308578 24681 140670 84016 59317 25400 116563 25023 171140 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME%R-RNO-203641.1 NOSTRIN mediated eNOS trafficking 311111 682507 25751 24600 25404 PHYSIOLOGICAL FACTORS%REACTOME%R-RNO-5578768.1 Physiological factors 116564 114593 24602 24603 289596 ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME DATABASE ID RELEASE 60%9438657 Adrenaline signalling through Alpha-2 adrenergic receptor 24175 25083 METABOLISM OF VITAMINS AND COFACTORS%REACTOME%R-RNO-196854.1 Metabolism of vitamins and cofactors 307092 171516 54225 361185 64365 100911394 683849 291939 25680 367323 85496 361819 25668 83578 361472 315085 25702 25052 305889 688517 299858 29527 361751 24778 293504 100912521 362134 116673 24312 84594 81522 58920 297508 25592 499330 499328 292697 24539 171517 25728 25527 300886 353255 25649 300027 103690254 751787 289095 25216 691984 29142 290947 305248 365592 287379 303676 680308 362347 100125370 246046 298653 24771 408247 29309 361300 299857 116719 170551 24624 50622 311655 294972 50621 58813 365699 302422 286921 299699 25035 680668 680432 24856 289175 361884 500820 288240 309465 25104 303333 25615 81506 303905 301221 316062 300691 25732 295229 317322 313520 64001 315023 299196 24479 25081 54349 64533 102554637 64392 311536 314459 29723 100911034 80848 498332 291283 363069 296167 362942 300328 103690044 24691 103689921 298490 294088 287711 362757 309004 24710 313706 687861 362653 50671 315644 362851 25056 64300 362558 362657 296972 25703 55939 64047 114106 116463 25571 191574 294753 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%R-RNO-450321.1 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 313121 100910771 317546 287398 500133 50658 679539 363855 116725 308267 362418 363520 100912618 309295 291912 116554 315139 296390 362491 311245 25272 SELENOAMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 60%9439044 Selenoamino acid metabolism 294103 58819 81676 363285 500255 29443 300691 64640 24250 79049 25134 116686 24962 25331 SIGNALING BY RHO GTPASES%REACTOME%R-RNO-194315.1 Signaling by Rho GTPases 84014 303501 301709 307459 299145 63994 288093 367085 315530 314903 362842 84031 306004 302819 303222 296060 307016 305367 498130 362456 500287 299012 293947 100363276 295971 308021 25183 58834 295635 362378 117281 103694903 690130 308875 24244 309179 83724 81745 29495 25614 691318 363131 24672 24673 297176 300115 312108 307178 312113 679082 305341 500246 498282 311193 310074 24242 291694 688429 308097 171296 500901 501456 296323 306279 310833 314618 306357 25486 287156 308666 116590 360854 83502 29432 50689 361617 301701 298594 304813 286993 308443 100911204 293860 362548 308761 297383 311793 302976 681050 317252 500904 100910732 308516 684439 100910474 294712 304951 363875 304477 293660 684969 360620 298850 501706 312754 287598 58823 363028 363174 100909840 691493 289150 305270 292279 83572 360564 81531 361416 100911597 85428 24669 315164 65052 295661 25594 102551071 313024 311191 296313 315151 291441 681185 79115 287876 300030 25448 500569 65172 316425 301009 296137 309774 103692165 257649 679934 79249 83836 114243 685867 257644 29355 308572 83620 114764 315648 303073 362816 299147 207122 116670 29648 114004 498310 114514 306400 311327 306464 54227 117542 100361457 303037 114553 690538 685883 307511 117538 288669 317576 682507 304740 314212 499933 29491 81822 360678 64303 81732 102551184 303351 294429 303251 299706 29741 100360868 246217 140898 680097 292085 310460 361223 295277 78966 100912489 84009 310635 117056 364723 361921 64373 83805 303634 363509 307098 103693372 85252 296603 287830 304109 687105 114559 117020 293024 102548682 300955 100362710 366957 116555 292750 363460 310192 100360950 317371 85384 683983 500351 301334 310999 81738 362648 304193 290541 311647 679983 25537 309653 295378 297518 102557184 29431 29433 315348 171576 64515 680006 313017 29753 100909750 25576 307483 298795 66021 56011 56010 361662 311860 25577 81504 313845 362590 500545 114592 362965 293733 64041 25156 65201 361598 310621 307505 362044 309159 171529 287624 29417 64465 60377 291159 289820 81762 297173 100911545 691496 79129 170845 24582 314906 307805 361029 288057 25745 84391 362186 100909726 360886 297522 29662 304447 24153 259242 25744 362893 501099 315298 363059 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME DATABASE ID RELEASE 60%9438642 Orexin and neuropeptides FF and QRFP bind to their respective receptors 60337 25593 78964 25605 100909783 500157 64107 310327 25723 379044 GLYCOPROTEIN HORMONES%REACTOME%R-RNO-209822.1 Glycoprotein hormones 24504 29200 64549 25329 116700 25447 25653 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%R-RNO-114604.1 GPVI-mediated activation cascade 25233 366508 24514 24185 246144 85243 24497 652957 25326 116630 140924 114103 64373 116562 296603 84477 406865 81745 116689 366957 81504 155918 25513 25522 81515 297173 29414 295378 25441 25704 298947 25150 500336 171081 25622 497931 85385 497932 84598 81511 363875 308875 25155 25156 25746 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 60%9438609 Role of Abl in Robo-Slit signaling 304883 360272 58946 311860 58920 100909750 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 60%9438725 Sphingolipid de novo biosynthesis 307855 366984 498300 360833 292658 309147 286896 308589 365410 288783 65278 365652 366697 361213 301118 499210 366065 305684 304208 85421 65183 60431 192270 500651 301543 306351 310667 58970 289322 64369 100362555 58857 296188 313339 313834 246115 314438 499174 100188936 SIGNALING BY WNT%REACTOME DATABASE ID RELEASE 60%9438281 Signaling by Wnt 291983 289924 289990 58854 300837 29425 117281 29675 29671 29670 24968 24967 29666 117263 117262 364814 290206 103694903 161475 83499 24244 309179 29614 689852 303353 29668 292766 691318 100362634 24672 365388 81827 24673 304794 24242 94198 29630 296651 408248 64558 24400 50664 365901 301965 307821 307641 116549 24674 54244 291209 83721 80722 500666 503000 499593 25221 293990 81678 100361818 246768 65027 312936 308692 293649 100912050 25023 290317 287102 293897 85492 289026 679110 291678 363875 140586 293165 303811 25233 312754 24185 287716 25404 29322 58822 24654 315648 299147 500863 25400 303181 286994 290829 295251 691857 300673 299802 499918 303412 498233 296121 313589 312781 498997 304832 65046 113927 266715 314212 24881 58868 64156 501584 497961 50522 140584 289878 100360552 690516 161452 306782 25581 24681 64512 116561 297893 688297 282581 307799 307401 64303 315259 116563 83800 102551184 303251 680097 295277 100912489 364723 309512 24680 681260 85252 25520 84576 102548682 290794 100360950 500351 308578 300084 679983 498837 140670 100912032 102557184 64566 25388 54241 309419 81637 29748 83806 287670 313121 81650 361765 171379 100910771 25679 25262 29669 29417 362356 29677 316527 29672 362065 25565 297173 84424 362533 84426 287357 299636 361846 287772 24882 288666 316526 287280 114487 25479 287984 114850 303586 311078 315196 116466 282582 500047 24205 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME DATABASE ID RELEASE 60%9438316 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 291983 290875 361389 64515 289924 296558 291689 366381 289990 311412 100360936 361831 304490 58854 307821 29425 64156 83806 294790 287670 29675 50522 29671 29670 24968 114592 24967 25581 29666 117263 117262 364814 290206 161475 85492 83499 29614 29669 689852 64193 303353 681260 287716 29668 292766 314642 29677 29672 365388 81827 498837 261730 296368 360643 287772 498030 100912032 305420 293155 287984 311078 94198 29630 296651 408248 FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME%R-RNO-6781823.1 Formation of TC-NER Pre-Incision Complex 361181 171150 289561 294693 497967 304343 103690054 245976 298508 364834 361365 287367 363283 312710 84389 64156 292778 690966 261736 363273 308415 288651 50522 691642 502227 362394 246216 314061 117017 83503 298074 360471 291703 362479 681260 498109 100361574 366163 64470 100911295 363633 300084 310071 498837 266713 100912032 360915 306274 360704 100912534 294236 302502 498453 361580 DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME DATABASE ID RELEASE 60%9438043 Displacement of DNA glycosylase by APEX1 315344 29541 114521 81528 680915 304577 24561 79116 170841 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME DATABASE ID RELEASE 60%9438858 N-glycan trimming and elongation in the cis-Golgi 81519 294410 140808 295319 362625 TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME%R-RNO-5633008.1 TP53 Regulates Transcription of Cell Death Genes 691278 64314 314756 290995 140923 25533 100910137 58983 24942 100911519 103690163 100359464 300711 293625 SIGNALING BY NOTCH1%REACTOME%R-RNO-1980143.1 Signaling by NOTCH1 50522 84010 498837 297767 25496 100912032 681260 687424 64156 500695 679028 54244 303101 CLASSICAL KIR CHANNELS%REACTOME DATABASE ID RELEASE 60%9438914 Classical Kir channels 29712 117052 276720 116649 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%R-RNO-2299718.1 Condensation of Prophase Chromosomes 500351 24708 25203 299557 306594 317425 300149 680097 679983 362798 295277 100912489 102557184 364723 689820 102548682 102551184 295107 100360950 362519 54237 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME DATABASE ID RELEASE 60%9438296 Regulation of Glucokinase by Glucokinase Regulatory Protein 300259 299706 292085 117021 304862 58958 245922 113929 65274 287830 116555 362281 25281 683983 295692 291874 81738 499974 113975 24385 25497 362335 25658 53372 294429 NA+-DEPENDENT GLUCOSE TRANSPORTERS%REACTOME%R-RNO-428808.1 Na+-dependent glucose transporters 366441 64522 25552 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%R-RNO-1474151.1 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 29244 171128 29498 24244 29270 24242 297402 24185 25523 24600 299331 INTERLEUKIN-17 SIGNALING%REACTOME DATABASE ID RELEASE 60%9438021 Interleukin-17 signaling 291983 171109 24514 246145 289924 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 58854 102552659 170668 29425 65179 24408 25167 64030 24716 24410 24412 117281 24446 498576 29675 29671 29670 29376 24968 24967 29372 690919 25704 112400 29666 24337 24329 117263 117262 116663 364814 290206 24592 103694903 64022 161475 360814 24703 83499 24245 24244 25267 309179 29614 29496 29211 295234 689852 64363 24497 652957 116630 140924 114103 24246 303353 289257 84423 84422 29668 29495 25614 292766 691318 25266 362572 360573 60427 24672 309168 365388 81827 24673 288924 171081 24242 291245 94198 296072 29630 81511 296651 408248 304893 24586 25746 116590 307821 50689 85492 83613 312754 300980 66023 25525 25326 314612 305203 312664 25136 432361 287716 114858 58960 192126 29542 192213 25467 192117 364052 246150 315648 305614 299147 288589 25400 25150 59323 25344 171140 84598 170577 59325 25433 25676 310533 303024 689314 363855 314322 81771 308267 363520 64156 498003 296390 25272 24498 691516 287398 50522 100912585 315305 25581 114509 81647 297520 305451 309361 289014 81646 84351 89807 89804 83805 681260 64159 498837 116725 100912032 362045 56011 291912 79114 81504 170633 83806 170700 313845 314384 287670 54250 25443 25444 313121 170579 316213 500133 293621 314850 679539 25317 170583 29348 29349 84489 24605 25114 81649 25022 362418 29368 116499 25622 100363500 361765 60662 85385 170582 315139 311245 25205 362417 24525 66017 114495 60464 100910771 317546 50658 29669 361565 116596 303200 315994 100912618 312679 501560 116554 24516 362356 54237 29677 29672 301289 501996 287772 117269 287280 287984 311078 309295 306247 362491 81736 60587 309957 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%R-RNO-1358803.1 Downregulation of ERBB2:ERBB3 signaling 50522 24185 29496 498837 100912032 112400 362814 24337 432361 681260 102552659 64156 296121 SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME%R-RNO-1855191.1 Synthesis of IPs in the nucleus 306808 171458 59268 50560 CA ACTIVATED K+ CHANNELS%REACTOME DATABASE ID RELEASE 60%9438911 Ca activated K+ channels 54263 294961 65206 29747 83731 54262 310303 66016 54261 METALLOPROTEASE DUBS%REACTOME%R-RNO-5689901.1 Metalloprotease DUBs 64557 289468 50522 298247 498837 497672 100912032 287362 681260 311078 290631 171565 64156 316794 293570 290997 687696 362704 498798 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME DATABASE ID RELEASE 60%9438818 Heparan sulfate heparin (HS-GAG) metabolism 84406 116673 114002 58920 293722 25592 64537 311215 364675 171517 299907 302489 290959 303218 316033 360630 363618 25615 103690051 25216 691984 58982 25181 360904 294449 29633 64544 684979 64134 29139 292155 293451 50568 298690 114122 24434 317322 25393 81651 316325 24771 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME%R-RNO-72706.1 GTP hydrolysis and joining of the 60S ribosomal subunit 103692785 140655 287417 360572 292964 64156 367865 103690821 367265 100910180 294282 29236 100360647 100911575 140662 100364265 100360841 103690015 684988 691531 140661 64640 100360057 29283 367195 100360619 29284 100911847 103692831 81729 28298 100360679 26962 64302 103693375 290641 689284 362041 100360117 296709 103694404 317646 29288 81767 29282 81763 100360522 81768 81765 81769 64205 311120 681260 301299 100362830 690468 314652 81775 81770 29752 64638 81776 25348 306079 103694169 65139 297756 498837 100912182 300079 100912032 25347 682793 100910370 685963 124440 306926 687780 29258 100359922 161477 65043 25538 499782 100361079 THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 60%9437929 The phototransduction cascade 24244 24400 295500 25318 79222 301233 498869 316218 25539 499132 59077 363143 29481 83579 289878 680149 259274 688297 307401 116556 81760 291318 64511 24242 140936 317498 85259 83686 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME DATABASE ID RELEASE 60%9438444 Beta-catenin phosphorylation cascade 312754 24672 309179 24673 113927 315648 299147 308692 501584 103694903 24205 679110 691318 117281 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME%R-RNO-168164.1 Toll Like Receptor 3 (TLR3) Cascade 303024 116590 25493 689314 363855 314322 292892 81771 308267 363520 64156 291912 498003 296390 50689 25272 117281 314384 313121 287398 50522 500133 100912585 679539 315305 114509 81647 301059 81649 362418 305451 116663 100363500 309361 361765 289014 81646 103694903 309165 315139 311245 84351 114495 100910771 317546 50658 361565 300980 116596 303200 315994 100912618 681260 501560 116554 24516 362356 81722 287707 24672 309452 24673 498837 315648 117269 116725 100912032 287280 309295 81736 362491 25742 60587 305751 309957 81525 304859 54226 TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME%R-RNO-6804115.1 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 308311 306492 295707 363603 305909 83722 291841 29619 360917 299805 312227 58936 363221 301513 307511 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 60%9437786 CDK-mediated phosphorylation and removal of Cdc6 291983 289924 29614 29669 689852 289990 303353 58854 681260 307821 287716 29425 29668 64156 292766 83806 29677 287670 29675 29672 50522 365388 29671 81827 29670 24968 498837 360621 25581 24967 287772 100912032 29666 287984 117263 311078 117262 364814 94198 290206 29630 296651 161475 362817 408248 85492 83499 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190239.1 FGFR3 ligand binding and activation 54250 29368 116499 25444 60662 366061 25317 170583 29349 84489 66017 60464 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 60%9438777 Mitochondrial tRNA aminoacylation 310856 ACTIVATION OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 60%9438676 Activation of AMPA receptors 29628 29629 29627 RNA POLYMERASE I PROMOTER OPENING%REACTOME%R-RNO-73728.1 RNA Polymerase I Promoter Opening 500351 100360868 680097 679983 295277 100912489 691496 117056 102557184 364723 25574 103693372 680172 291159 102548682 50689 102551184 100360950 SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 60%9439262 Synthesis of PIPs in the nucleus 364298 89812 RELAXIN RECEPTORS%REACTOME%R-RNO-444821.1 Relaxin receptors 266997 25616 363866 114215 295144 294807 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME%R-RNO-380320.1 Recruitment of NuMA to mitotic centrosomes 25203 680991 362980 299730 692032 252921 362203 287929 306599 308663 54237 308870 309098 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 60%9437945 RNA Polymerase I Transcription Termination 171150 294693 498109 100361574 84389 690966 499766 308415 288651 502227 266713 25574 363017 117526 690450 680493 361420 83503 100912534 287710 294236 313245 301246 83582 361580 83581 362728 291703 361784 CATECHOLAMINE BIOSYNTHESIS%REACTOME%R-RNO-209905.1 Catecholamine biosynthesis 24661 24311 25699 25085 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 60%9438692 Nucleotide-like (purinergic) receptors 310444 317219 29316 25369 302378 171108 100911796 691774 25265 63843 117264 64803 29597 100363178 29290 767613 25370 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME%R-RNO-425393.1 Transport of inorganic cations anions and amino acids oligopeptides 64076 363103 155205 140447 140448 25550 311651 266767 24782 24781 287478 83612 84487 24780 25548 170573 363115 170567 305540 50719 317170 113918 25648 298340 24785 116726 24783 170566 24784 84484 29502 29501 310392 302863 314396 24779 29715 24244 114629 252919 117267 117261 282712 29440 29642 84550 84551 295645 683667 170943 64554 664630 297386 171373 117955 25065 366432 192208 24242 308069 192215 266612 312192 307811 29485 311387 246239 246235 83629 691209 292657 287532 83509 246234 500820 29484 29483 50676 114518 315439 297910 114613 314441 304784 29464 498185 84012 301010 309111 311168 81826 315311 116638 29323 681896 54300 100911440 SIGNAL ATTENUATION%REACTOME%R-RNO-74749.1 Signal attenuation 313845 498416 85385 29376 25467 24954 81504 50689 24506 24505 BASIGIN INTERACTIONS%REACTOME%R-RNO-210991.1 Basigin interactions 307811 80878 24796 25518 360746 84551 83509 50687 100360977 288521 65200 25404 114517 50719 114518 25246 29409 116726 25027 24214 300339 360606 25650 310392 25390 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-RNO-5693571.1 Nonhomologous End-Joining (NHEJ) 64557 64046 64012 680097 85482 295277 301442 100912489 497672 364723 308669 309595 290631 361815 316794 500987 498749 102548682 289757 259171 100360950 311944 290997 361767 362704 500351 309995 290907 296099 287927 289468 360748 679983 680537 363251 116725 102557184 362827 363247 102551184 300711 25019 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 60%9438443 Degradation of beta-catenin by the destruction complex 291983 289924 113927 289990 58854 307821 29425 64156 501584 83806 117281 287670 29675 50522 29671 29670 161452 24968 24967 25581 29666 117263 117262 364814 308692 361765 290206 103694903 161475 85492 679110 83499 312754 309179 29614 29669 689852 303353 681260 287716 29668 292766 691318 362356 29677 29672 24672 25565 84424 365388 300084 81827 24673 362533 498837 299636 287772 315648 100912032 287280 299147 287984 311078 94198 29630 296651 408248 24205 NUCLEAR SIGNALING BY ERBB4%REACTOME%R-RNO-1251985.1 Nuclear signaling by ERBB4 24890 24918 363014 59323 100911293 300802 691658 81751 365872 292788 289231 RHO GTPASES ACTIVATE CIT%REACTOME%R-RNO-5625900.1 RHO GTPases activate CIT 297173 29495 308761 83620 64373 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME%R-RNO-446107.1 Type I hemidesmosome assembly 114517 316313 100911730 192362 64204 25724 294027 64315 307582 305078 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 60%9438565 Platelet degranulation 89811 56782 246328 360950 24854 24628 361196 360942 295703 686539 364206 309186 81804 114111 305679 360457 116635 294643 308291 100359512 304805 299052 24446 24791 59086 299277 81634 499985 103690020 445442 54249 24617 85253 24944 24244 25717 25266 288001 24903 299276 24482 24189 81809 24825 24242 291245 84491 24483 170924 54226 25373 100365047 25524 293860 140656 29184 83785 29186 246358 25081 116669 313494 24366 25661 361969 24367 29302 685269 84590 304983 307986 25673 305021 317191 316531 302470 25651 300988 24786 113947 24936 140594 293886 296488 311795 100911881 309609 25358 100912012 100911545 297073 363104 500152 293676 360918 171016 307396 81750 363195 64312 54404 58935 309647 287774 60327 24153 299909 498299 63836 116662 116510 245955 312159 50693 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME%R-RNO-438066.1 Unblocking of NMDA receptor, glutamate binding and activation 24245 83613 246150 29629 24246 29627 29628 25400 291245 24408 171140 29495 24410 24412 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME DATABASE ID RELEASE 60%9438845 TRAF6 mediated IRF7 activation 24508 290749 690894 298205 502965 100912356 298211 502966 292892 502962 298210 24481 310461 301059 500491 100911527 103690314 54244 100912314 TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME DATABASE ID RELEASE 60%9438926 TWIK-related spinal cord K+ channel (TRESK) 445371 LEUKOTRIENE RECEPTORS%REACTOME%R-RNO-391906.1 Leukotriene receptors 114098 114099 170926 767613 59264 ELASTIC FIBRE FORMATION%REACTOME DATABASE ID RELEASE 60%9438960 Elastic fibre formation 313662 287382 252835 59107 25717 29302 311061 83727 25296 83838 362429 293677 29373 59086 292734 287299 315191 25043 85272 364786 81809 102553715 362800 305604 24914 54281 29169 282583 315714 29158 CELL JUNCTION ORGANIZATION%REACTOME%R-RNO-446728.1 Cell junction organization 83502 308417 316313 114517 293860 192362 64315 307799 81634 25066 305078 361432 81918 83501 307505 81679 64204 84006 140581 301112 307237 314259 363509 362279 294027 116479 362332 29163 362973 307618 170922 497229 499443 360687 361517 84407 680419 288124 498515 307582 311163 362650 289992 29162 26955 192183 192248 100911730 117048 25409 25724 360652 498281 29181 116777 360882 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-RNO-2197563.1 NOTCH2 intracellular domain regulates transcription 29492 297767 679028 303101 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%R-RNO-381038.1 XBP1(S) activates chaperone genes 298068 288919 361273 309858 80881 689134 80843 294912 CONJUGATION OF CARBOXYLIC ACIDS%REACTOME DATABASE ID RELEASE 60%9438174 Conjugation of carboxylic acids 246263 293779 361638 COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME%R-RNO-6807878.1 COPI-mediated anterograde transport 81754 304978 84599 65134 252902 361577 60355 500251 100910557 56042 246310 306570 64154 171049 690961 362162 24506 24505 64351 360611 29631 140673 363136 315345 192243 503165 94189 297428 290659 56082 100126191 362504 29167 29211 81655 29564 290798 84428 116659 289257 140734 308961 299850 64159 310411 65165 300674 114023 361407 361207 305614 361073 300888 309451 303652 293456 102555167 291990 79120 25407 100363782 MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME DATABASE ID RELEASE 60%9438790 MAP3K8 (TPL2)-dependent MAPK1 3 activation 303024 50522 498837 116596 287280 100912032 681260 305451 64156 361765 309295 309361 81736 84351 362356 MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 60%9438325 Mitotic Anaphase 291983 289924 304740 289990 58854 29425 64156 499933 117281 304218 314949 29675 50522 29671 29670 24968 25581 24967 29666 117263 117262 364814 290206 103694903 63996 290577 29486 161475 305343 313304 315958 83499 294429 299706 309179 29614 292085 689852 303353 85252 681260 287830 29668 116555 292766 691318 683983 81738 24672 365388 81827 24673 297176 498837 296368 360643 498030 100912032 305420 293155 94198 29630 296651 408248 171576 290875 361389 64515 680006 296558 291689 366381 311412 100360936 361831 117104 304490 361662 307821 83806 301701 287670 298594 286993 308443 100911204 362548 500545 114592 362965 293733 681050 317252 64041 684439 85492 294712 304951 304477 65201 25437 298850 114087 501706 312754 287598 60374 363028 363174 362779 29669 362044 691493 289150 315330 171529 305270 287624 64193 83572 361416 24669 315164 295661 684771 287716 311191 291441 681185 25448 316425 363481 29677 296137 29672 257649 83836 257644 287772 114764 315648 299147 287984 170845 29648 307805 311078 498310 114514 311327 84391 362186 306464 360886 297522 303037 363059 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME DATABASE ID RELEASE 60%9439061 Activation of NIMA Kinases NEK9, NEK6, NEK7 25203 360161 54237 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%R-RNO-3371453.1 Regulation of HSF1-mediated heat shock response 300259 293103 299706 297994 116590 685055 292085 117021 304862 29753 293524 303536 58958 245922 113929 690038 65274 287830 116555 361167 362281 50689 25281 59102 361384 683983 295692 291874 81738 689955 499974 287524 113975 25497 362335 296883 103690404 362293 289014 79245 81800 306007 300711 53372 366734 288444 294429 METABOLISM OF COFACTORS%REACTOME DATABASE ID RELEASE 60%9438644 Metabolism of cofactors 365592 29309 498332 24479 TRANSLATION%REACTOME%R-RNO-72766.1 Translation 24206 29565 64156 116650 291685 690345 363707 299872 100360057 367195 100360619 100911847 81729 293700 498351 361842 171361 310856 24420 100911685 307503 681260 291615 501582 498837 100912032 103692785 140655 362952 287417 360572 292964 367865 103690821 100912571 367265 100910180 294282 116636 29236 296076 100360647 100911575 140662 100364265 100360841 103690015 684988 691531 295975 140661 64640 29283 56783 29284 103692831 28298 287436 100360679 26962 64302 302697 103693375 290641 689284 362041 192234 295660 300253 100360117 296709 103694404 117019 300033 296302 363241 317646 29288 81767 29282 81763 100360522 81768 81765 81769 64205 288599 311120 301299 100362830 292148 288309 690468 314652 293725 81775 293427 81770 29752 64638 81776 292762 299027 25348 300069 306079 103694169 293484 288516 65139 297756 64514 100912182 300079 171145 298700 117045 25347 682793 294504 100910370 685963 124440 306926 691947 687780 29258 54318 100911110 100359922 161477 65043 25538 499782 100361079 303831 GENE EXPRESSION (TRANSCRIPTION)%REACTOME%R-RNO-74160.1 Gene expression (Transcription) 289924 65261 79240 292804 25574 363017 297093 690450 680493 361420 501688 366468 364298 313245 308869 83582 83581 292884 362728 681062 361784 295234 303353 298696 25533 58983 24942 25329 360917 299805 312227 363221 301513 308311 306492 295707 363603 365388 291841 94198 116700 314856 303132 304798 266787 301119 311796 100910954 25562 305851 294258 287608 306261 306347 81785 305455 303281 291705 60571 360905 368002 307641 116549 50689 299604 83474 289307 85261 444985 296653 681740 297705 294287 84350 24890 314993 314818 308607 25747 25271 307511 286917 306665 362485 114851 362675 690728 83571 25729 83574 300807 306862 252917 58839 303241 361630 100363472 360896 619579 311807 499670 292064 361128 290995 58850 100910137 58853 50659 60349 361391 686781 679028 313777 361374 25664 290744 305025 305120 291736 303539 25203 305837 114491 171355 691278 309200 83722 54278 25682 362342 297767 25581 290669 299694 365744 297822 252924 362125 365895 362834 140923 259241 299210 316216 685072 29619 306817 103689975 298688 102549712 58936 684085 298681 691379 192350 299810 290805 245980 116671 64046 304514 100362315 363924 24831 117535 116698 306734 301014 293701 85482 361988 64314 300782 117274 361724 24706 24705 308755 301285 361836 309288 65035 311613 311414 289372 685619 83826 289382 294276 296102 100911519 103690163 25149 100359464 290322 362272 100361543 303101 314862 100909544 314465 307829 81808 24873 25735 362813 360589 25112 81812 497991 361057 311591 308582 246334 309918 140908 84385 293625 100365683 24887 362045 306998 89812 83806 84577 287670 64520 312947 114592 315713 81650 81649 362280 363287 315170 290519 361990 303057 114490 29669 89827 360845 362819 679894 305714 29417 362078 313308 360972 302729 680172 114612 500378 79227 291797 25154 308911 302553 361798 29677 29672 58852 685474 25496 58851 56761 314756 406162 287772 363227 310614 679713 287984 308837 311078 29492 60351 291983 26954 293184 289990 58854 300837 29425 366169 64562 287871 56718 117281 282844 301518 29675 295052 298514 29671 140926 115771 29670 282845 24968 24967 29666 362858 117263 685539 117526 117262 310131 64525 310685 311487 81807 300088 103694903 361640 29517 171068 114212 366277 362817 161475 171063 301246 60445 296648 304204 300711 311575 362095 64226 362088 114494 361858 83499 25405 287113 361859 29614 689852 298075 24855 689890 29668 81745 292683 100362346 494445 292766 304714 687575 499766 691318 366952 310091 681031 688288 24672 81827 311670 24673 365407 362264 298385 29630 687679 296651 408248 297960 116550 64557 103695118 288533 81673 100361529 291773 64012 682902 294018 685055 291787 83828 293345 498411 310784 294800 310034 171152 100360100 497672 310511 497856 315969 306516 303918 83830 307821 24377 307485 170844 54244 85492 305909 83803 24185 65248 311546 360776 287716 261730 295357 315648 78975 100909655 293104 312299 117044 363064 116484 498183 117043 313048 361531 364382 171150 304832 289561 294693 116468 288003 689314 103690054 301442 364834 362594 361365 25737 84389 64156 292778 690966 59102 304758 308415 288651 100911453 444984 59086 300947 29357 50522 365894 690516 307766 81822 83712 502227 680111 306571 114208 499929 300813 297893 117017 362110 689820 363292 363445 84396 25631 81920 360801 315291 83503 360471 310769 100360427 58919 361178 102551184 116651 25591 53372 291703 316742 294429 691231 311130 65160 300259 299706 100360868 298533 680097 114521 292085 117021 59117 304862 295277 100912489 117056 364723 58958 245922 83805 113929 362479 65274 681260 103693372 287830 498109 308971 100361574 363006 500715 84509 304528 84473 299284 84576 25573 316108 102548682 116555 500695 363462 641452 499391 362281 24790 685068 192178 25281 295062 362688 84404 100360950 497958 683983 295692 64301 500351 291874 81738 499974 313593 363633 313594 287524 679983 113975 498837 266713 303774 102557184 100912032 25497 362335 296883 363014 306274 100912534 287710 294236 288414 498453 361580 116697 294518 687711 502894 288701 58819 317399 316123 314417 117254 140942 313017 29753 25576 680737 298795 361831 56011 56010 171365 311166 81674 313449 25577 689116 361814 502988 116686 29667 291877 307524 84486 308335 690303 291794 309338 295284 100360682 362612 361605 313620 361542 362687 24525 114495 691501 683927 316810 361102 299256 291534 313131 298916 308472 291159 685465 304277 294687 306542 292007 690254 306012 680309 246299 54237 299347 362537 691496 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%R-RNO-2995383.1 Initiation of Nuclear Envelope Reformation 25437 114087 60374 24672 362779 103694903 117104 117281 TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-RNO-6803207.1 TP53 Regulates Transcription of Caspase Activators and Caspases 64314 100911519 314756 300711 293625 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME%R-RNO-435368.1 Zinc efflux and compartmentalization by the SLC30 family 58976 298786 25362 294698 299903 MITOCHONDRIAL UNCOUPLING PROTEINS%REACTOME DATABASE ID RELEASE 60%9438225 Mitochondrial Uncoupling Proteins 85263 25708 100909612 24860 54315 PI-3K CASCADE:FGFR3%REACTOME%R-RNO-5654710.1 PI-3K cascade:FGFR3 54250 25444 314850 25317 170583 29349 84489 361388 29368 116499 25622 60662 81504 25513 66017 60464 SIGNALING BY NOTCH3%REACTOME DATABASE ID RELEASE 60%9438159 Signaling by NOTCH3 100911293 300802 691658 84010 81751 365872 311332 56761 292788 289231 29146 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME%R-RNO-75035.1 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 25203 25577 313017 29753 25576 298795 56011 54237 56010 307511 308937 RHO GTPASES ACTIVATE ROCKS%REACTOME%R-RNO-5627117.1 RHO GTPases Activate ROCKs 297173 25537 64373 81762 L1CAM INTERACTIONS%REACTOME DATABASE ID RELEASE 60%9438028 L1CAM interactions 81637 65046 25416 246331 116590 29211 171574 29302 685269 364686 83805 289257 116690 296603 29686 245956 50687 306570 79114 307641 116549 64159 50689 83841 292139 58960 308578 29423 497815 54319 83510 140670 305614 81650 24329 29431 84393 116563 83800 140694 25751 54241 25744 363875 116743 24586 VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%R-RNO-196819.1 Vitamin B1 (thiamin) metabolism 303676 305889 680668 289175 E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME%R-RNO-8866654.1 E3 ubiquitin ligases ubiquitinate target proteins 100365043 304832 295274 100910200 313216 680403 293184 24829 100912338 298317 308282 361831 361247 25737 300837 64156 100909787 297337 366169 306969 64647 680312 100909597 266712 287927 50522 116718 293561 81920 681260 641452 498837 684797 680424 83477 116725 100912032 100364835 307029 295568 306945 117044 363064 29534 100359692 362412 361531 312703 291157 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 60%9438275 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 681236 313845 361618 84357 171055 366508 100913063 89821 25679 499356 25262 365367 362046 500985 81678 25738 294048 85385 300955 171136 81504 25513 25155 25156 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME%R-RNO-69183.1 Processive synthesis on the lagging strand 59294 287524 85242 84490 361698 301323 246327 361836 296883 25737 289758 59102 81513 100911727 FCERI MEDIATED NF-KB ACTIVATION%REACTOME DATABASE ID RELEASE 60%9438503 FCERI mediated NF-kB activation 291983 303024 289924 25493 289990 361831 308267 58854 307821 29425 64156 296390 83806 287670 313121 29675 50522 29671 29670 679539 24968 25581 24967 29666 117263 117262 364814 309361 361765 290206 85420 309165 315139 161475 85492 311245 84351 83499 100910771 317546 29614 29669 689852 303353 100912618 681260 287716 29668 81745 292766 362356 29677 29672 81515 365388 81827 498837 83477 287772 116725 100912032 287280 287984 311078 94198 309295 29630 296651 81736 408248 RUNX3 REGULATES NOTCH SIGNALING%REACTOME DATABASE ID RELEASE 60%9439318 RUNX3 regulates NOTCH signaling 297767 500695 679028 25496 303101 54244 TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME%R-RNO-69560.1 Transcriptional activation of p53 responsive genes 100910954 685474 DOWNSTREAM TCR SIGNALING%REACTOME%R-RNO-202424.1 Downstream TCR signaling 291983 303024 289924 25493 289990 361831 308267 25710 58854 307821 29425 64156 296390 25513 83806 287670 313121 29675 50522 29671 29670 24968 679539 24967 25581 29666 117263 117262 364814 309361 361765 290206 85420 309165 311245 161475 85492 84351 300678 83499 309621 29741 100910771 25300 29614 315609 29669 309622 24932 85243 689852 54259 50557 303353 294269 100912618 681260 287716 29668 81745 292766 688090 24981 362356 294270 29677 29672 365388 81827 498837 83477 287772 116725 287280 100912032 287984 311078 309295 94198 29630 296651 81736 408248 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 60%9438012 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 140944 100911721 63997 60423 116642 288499 65194 353307 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME DATABASE ID RELEASE 60%9438704 Regulation of actin dynamics for phagocytic cup formation 288669 308666 116590 360854 682507 100909750 310178 65261 311860 81504 50689 299331 301252 81822 100911825 81732 103693683 363875 25155 300678 684969 25156 360620 58823 25300 116591 289211 64465 296603 313024 54245 300955 289820 25614 287876 498276 317371 295279 65172 301009 304966 679934 79249 295378 297518 303073 299354 29431 309081 361251 54227 362271 117542 315348 100361457 259242 117538 SYNTHESIS OF PA%REACTOME DATABASE ID RELEASE 60%9437968 Synthesis of PA 690388 362058 296623 29359 406165 294324 290843 363159 288322 24653 29692 367308 295305 29653 298579 362039 305166 306582 691905 311821 362702 361467 170919 296130 24197 295631 25096 287366 29526 84470 311341 100359675 60666 29354 680971 25097 296048 305816 ENDOGENOUS STEROLS%REACTOME%R-RNO-211976.1 Endogenous sterols 266761 24298 24294 83724 313929 25243 25242 25429 353498 25690 25426 500892 25428 81924 25427 362782 301264 313786 79122 100910462 29189 25271 60351 24664 25147 AMINE-DERIVED HORMONES%REACTOME DATABASE ID RELEASE 60%9438522 Amine-derived hormones 317675 24661 24311 79107 25085 266807 114613 54314 25653 246281 25699 116700 24848 308129 25120 TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME DATABASE ID RELEASE 60%9439199 TNFs bind their physiological receptors 498769 500592 301132 500590 500318 287034 89814 156767 287437 25069 353218 366518 302424 683163 25572 25008 296872 103689974 498666 25341 365581 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME DATABASE ID RELEASE 60%9438274 Activation of IRF3 IRF7 mediated by TBK1 IKK epsilon 292892 SNRNP ASSEMBLY%REACTOME%R-RNO-191859.1 snRNP Assembly 286917 364382 687711 680737 171365 689116 100911453 291794 312947 100360682 310769 53372 294429 691231 300259 65160 299706 292085 117021 304862 298075 58958 245922 113929 65274 287830 84473 316108 363462 116555 499391 362281 685068 362688 25281 84404 680309 683983 497958 64301 295692 681031 291874 81738 499974 113975 25497 362335 687679 SIGNALING PATHWAYS%REACTOME DATABASE ID RELEASE 60%9437871 Signaling Pathways 84014 303501 307092 301709 171516 307459 299145 63994 288093 367085 315530 314903 362842 84031 306004 302819 303222 296060 307016 305367 498130 362456 500287 299012 293947 100363276 295971 308021 25183 58834 295635 362378 362513 170820 140607 292770 312574 311331 29135 360658 58947 361396 303517 25532 83724 25329 300115 312108 307178 312113 679082 84578 305341 365865 500246 498282 311193 310074 291694 688429 308097 171296 500901 501456 116700 296323 306279 310833 24664 306357 25486 287156 295500 79222 301233 498869 316218 25539 499132 59077 301965 312477 25756 361617 25757 24596 83765 315691 24890 83785 25023 25589 25318 50557 296972 116556 81760 291318 64511 25271 140936 317498 85259 29622 29613 116478 25054 116546 300078 294376 291713 25682 298947 292697 24539 25728 25649 300027 309419 286921 313749 89812 94193 311401 308493 100911911 362828 291283 313388 25565 84424 362533 299636 116463 191574 497931 497932 100362554 300837 310131 29560 296648 298075 103691556 367100 25378 29530 25495 290921 686129 499508 298787 140590 60450 301333 140931 362814 59328 25237 289264 25050 81507 500485 29432 64044 24674 54244 291209 83721 80722 500666 503000 499593 25221 81678 293990 25061 353252 100361818 361504 246768 116676 313689 100910732 297805 685750 65027 312936 81517 117258 308692 293649 100912050 290317 287102 293897 289026 679110 291678 140586 293165 303811 307171 116669 313494 24366 25661 361969 24367 29302 685269 299511 24669 170635 25594 100911902 100365958 500629 24668 266686 25404 307618 301737 363616 116680 311163 290829 295251 691857 300673 287612 304832 307724 289711 303968 50938 691171 688749 113927 54223 302661 291936 100362124 289712 360715 362549 140588 65189 140589 65157 308265 361769 503018 300289 303039 305509 59320 501584 297387 293047 115769 312651 25273 304318 64508 289180 299116 84420 360920 287643 362265 308577 311622 304758 313477 59086 300947 29357 365894 690516 310655 680111 114208 499929 297893 307799 362110 81810 361509 287155 363445 84396 25631 81920 360801 315291 25639 54281 287607 100360427 361178 81918 116651 297699 316742 66018 79429 292406 29220 24680 85252 311676 83837 500715 84576 29591 500695 641452 24790 295062 25522 103690035 116479 301334 310999 362648 24816 304193 290541 311647 25537 309653 29413 29412 295378 29431 29433 316369 89826 24711 266714 293049 314264 363071 313838 316123 361505 361195 25193 58840 360635 54268 309175 81674 689116 64200 81527 310688 308444 57027 117268 363334 64015 170843 94203 54251 114110 316527 683470 362065 84426 302950 304729 287357 361846 295654 24882 364475 288666 305918 316526 305349 89830 114487 25479 361438 114850 303586 687424 315196 116466 282582 500047 94338 83537 25473 305104 306628 25353 117036 192362 305078 445442 298941 85253 309816 362285 29373 89823 25627 290905 362584 282822 60395 301701 298594 304813 286993 308443 100911204 293860 362548 308761 297383 311793 302976 681050 317252 500904 308516 171044 684439 100910474 294712 304951 24884 304477 293660 684969 360620 298850 501706 287598 58823 363028 363174 100909840 691493 171574 289150 305270 292279 360564 81531 361416 100911597 85428 315164 295661 102551071 313024 296313 315151 291441 681185 79115 287876 300030 25448 500569 65172 316425 301009 296137 309774 103692165 257649 679934 79249 114243 685867 257644 29355 308572 83620 303073 362816 207122 116670 29648 114004 498310 114514 311327 306464 54227 117542 100361457 303037 114553 690538 685883 307511 117538 114851 83571 83574 64547 306141 500526 304740 266715 314212 24881 58868 679028 497961 140584 289878 100360552 161452 306782 297767 24681 64512 688297 282581 307401 64303 315259 685072 64314 24706 24705 171119 29513 60352 300955 317371 303101 29749 25601 25638 29691 24611 360616 24626 290646 24471 315761 24627 29190 24675 140908 680006 445269 100909750 246244 311860 116498 500545 114592 362965 293733 29251 25439 29636 29200 245921 64041 24414 24373 29381 300054 114031 293674 29263 81859 60377 361167 56822 361384 25408 25660 266610 246775 25385 246097 117279 311786 246756 100911545 307582 316758 360606 140433 24153 25680 25702 117063 299858 363455 116673 58920 25592 171517 304794 25216 691984 24771 25615 317322 311191 679975 58822 685243 170896 83836 63850 288995 170634 117549 114764 367315 29151 29407 688605 60669 246075 171056 89808 316019 292310 94204 497078 29625 498183 252939 297025 408243 302619 310806 25692 450224 29409 259274 360678 58919 117089 687813 364386 300160 113955 64535 363014 116548 100911293 25507 300802 691658 81751 365872 297930 292788 83686 54226 79210 25031 362590 303886 498416 683206 84010 311332 29146 24225 81737 24175 25730 25083 84469 306886 24205 103693566 64636 293262 25360 366844 289924 366843 308163 25369 366816 100124593 246254 691774 29645 296037 366109 366103 293268 246219 100912408 29238 25111 293091 293289 25380 81821 117027 25726 25723 24889 293255 25370 360750 299331 500927 293083 293271 292794 293278 360579 54305 294138 293281 29234 293085 293285 688730 301066 497196 293279 29237 690572 362950 500409 307810 170538 690130 25107 308869 287910 312510 361655 308875 684170 25593 140868 293435 170667 295834 24419 287322 684171 295234 365523 287324 362384 684179 287321 287329 287328 25194 295347 287325 303353 366151 287310 117264 64803 25310 681706 287313 405239 100911893 287314 259222 405233 259224 64042 25187 287316 300414 29446 117257 500460 690158 309962 84348 29256 365388 363993 295827 300400 295822 295828 363710 103692138 295829 300408 366802 29462 366112 366111 293402 170704 94198 25706 293400 295801 310327 100909438 29471 690334 315452 314618 366100 100910500 292324 314856 100310881 25354 117029 100310886 100310885 25555 116590 25402 363761 363762 83502 363763 309222 293425 300640 366116 366115 366114 293424 295863 293429 294190 293817 295865 293815 293421 24808 29290 295869 94201 24806 24807 50689 294187 294186 293810 287309 300639 100912571 100310879 100310878 405242 116636 405249 100310875 405248 293812 366123 100310877 100310876 294394 84583 25570 24604 25569 405252 294198 170926 295858 405258 297795 364275 294197 405218 684376 300643 405219 24415 25195 24613 24416 363546 300253 100912958 25635 25637 81509 311180 405114 363549 405108 293399 405107 293398 29180 311179 293392 293394 103694905 311173 311175 81780 103693363 405106 405105 100910049 300395 24260 103690375 117064 100911586 289023 29191 81779 266997 301086 405287 25320 25321 301088 25323 25324 100911839 680188 295891 295890 362119 360918 117045 405281 66024 114098 114099 679957 353250 300603 405293 314386 287331 100310880 295870 309212 103690156 25340 366377 24659 25342 293375 296675 404984 293377 293373 83633 293374 29385 404986 405131 405132 84007 303296 404978 404983 293379 296679 296678 405136 404977 56820 56821 405137 25616 405138 116689 404976 296687 499933 498475 100910009 288006 689936 405133 296689 405134 24241 338443 404999 404971 405115 404998 405112 690230 287673 56813 502757 25581 292413 140928 140929 404975 293389 293382 292419 404970 404969 292409 404968 25605 404967 680358 405126 405121 502755 404981 293370 405125 405124 405123 24247 405122 89810 363585 405150 687088 103690410 100911398 690821 60448 100909831 406021 54258 24316 405166 365228 289240 405203 24318 405164 405160 289241 687097 100910928 113959 60432 60628 24323 24324 405179 24326 405177 64159 405178 299159 406018 288001 289251 405175 100361543 404948 81744 399475 296682 405146 405148 405144 81743 171551 406004 406003 404943 60665 293650 405140 100910719 405141 289261 293808 293809 404963 60451 293805 404962 404961 100363178 405158 315348 81749 404960 296694 81752 405155 100909862 81753 310444 100912515 81637 103693822 25666 100910294 362045 59301 686677 294203 302378 100909884 81503 100909683 307483 295144 58965 66021 294807 100909885 100910224 293336 293338 287613 287614 686660 361076 25524 25645 293334 289076 29141 81687 100911348 293340 100910999 293357 83806 102553138 100912505 171337 293327 287670 404797 100909894 293329 405185 405181 405180 293321 405183 405182 289254 100911796 289255 405171 289231 289250 81650 405174 305236 58966 81649 25689 499149 58959 684683 362505 308776 100911380 362506 293316 293319 406039 500089 404794 100911376 24953 29363 25298 361598 100912217 500347 100912327 100126231 29669 363826 100910599 81679 298006 293761 100365887 293763 293764 293769 25265 300524 300525 501177 114105 287003 24232 367065 367064 295910 29757 684208 293192 289820 116677 100909578 293188 767613 298396 84022 499194 81762 29677 57302 57301 57305 29672 317219 297173 29335 363866 64107 85268 100910467 24797 293333 64680 287772 58949 246759 25652 79129 25653 100909648 287984 314480 245920 690448 311078 301372 29358 64354 367745 293759 29662 100909534 295900 25248 81736 25245 362893 293140 103693685 295907 500101 192649 192648 171101 300560 171519 301610 405362 100912374 405366 171108 103690011 25447 295786 405365 25449 65032 170816 100912540 50577 29581 292661 29597 29595 315571 287000 192646 25040 405373 295772 408199 295771 54248 295766 24938 171371 103690286 295769 295767 295768 25075 405344 405345 405346 405349 314904 287247 25461 287245 295781 378939 171104 405368 405352 295754 24929 103690299 287240 287241 25477 554302 103690280 287237 295751 295750 65275 299553 290493 305841 690472 295744 299242 304985 405391 405390 25026 303835 295712 25432 25024 295713 293773 295732 25007 24769 500157 171158 299570 300599 299757 295747 293781 295743 293789 295741 114492 293785 25229 299576 366668 84475 24903 295729 24772 54293 689869 24473 405966 81638 100911988 299596 59076 59075 366274 299586 287481 299588 366270 287480 690481 25029 405383 25033 405384 295721 379044 405386 287484 287487 288816 288813 404826 100910837 404828 405948 102555599 404825 405955 405963 362454 308408 404820 81657 59264 100911043 364306 408031 404814 408030 404813 81648 404816 404818 24677 405969 100911035 24476 405003 405970 405971 81644 405325 405326 365302 287973 404858 405917 405049 405918 368088 405927 405940 25516 287970 288838 405928 405923 405934 404839 405935 286959 288181 288187 171054 287969 404832 83518 81668 24694 497942 302027 25504 405952 404861 405920 405921 404860 405331 287262 363682 100360071 405333 405050 100909966 405334 686967 405053 282839 405051 405919 405329 405337 50672 405911 288823 100911479 282832 404859 114215 100912097 405912 405915 404855 405914 103690304 114211 404871 404875 290010 404876 405026 405303 405023 290018 58812 286913 365330 288858 59293 365327 365326 365323 289923 365324 100359873 63885 405907 405904 63887 63889 405056 404862 24448 404863 405057 100911670 50678 404877 404878 53949 289561 404879 365334 365337 290009 405307 405312 103690054 290003 365336 290001 364834 405033 290005 361365 406163 290006 404885 404887 290008 365340 404891 64156 404894 292778 100363053 405034 690966 499860 404895 404898 404897 100909796 404888 29538 288879 290020 100912605 60590 288869 50522 100910640 287730 364979 81822 288866 290050 304610 405065 300813 405066 29555 117017 405064 100361138 684539 60337 192223 63843 140866 290049 405071 85420 83503 100910120 140595 100909493 288887 688705 499486 288886 25591 293223 287506 288198 100911944 89807 293226 293224 29741 89804 293221 288192 84427 288190 85243 287509 314649 363606 500317 298044 293210 60399 66025 293211 192206 306792 78979 292994 24166 83805 192205 78985 287077 681260 293218 298040 498109 100361574 305711 298042 293215 293214 309207 103693022 304289 78982 78983 305795 499913 78980 29254 78981 298038 298039 58918 78984 302954 405990 405993 287088 363633 302045 287080 300084 302958 29316 287082 498837 363639 287081 298046 287086 405991 100912032 287084 287083 29310 298049 24180 103693054 24182 298045 100912534 100910876 405988 287513 100910162 405982 24179 287516 287090 497978 287517 687110 78964 100909783 29748 313017 287093 405984 29753 25576 287514 405983 499237 298795 56011 405987 56010 405986 64639 405985 25577 79114 81504 170633 25513 170700 313845 54250 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 361388 25114 25738 25022 29368 116499 25622 60662 85385 170582 295401 116744 498609 29733 29415 24525 66017 60464 60383 362757 24710 315644 25056 362558 25703 55939 64047 114106 170845 24582 307805 361029 288057 25745 100909726 360886 297522 304447 259242 25744 501099 363059 89811 361714 315707 114111 360457 361696 294048 64545 84482 24954 50686 59109 79240 24506 24505 294235 84027 294515 365367 59265 366061 499308 305539 299236 360903 84006 64558 24400 50664 25686 81664 297566 60449 81667 689779 25643 117596 365901 363143 297797 291969 25740 29481 296981 294962 83579 307641 116549 297932 286924 116455 366545 289407 362802 294981 360302 117255 94170 685232 310836 25081 362524 89817 24536 83572 24653 29322 89788 81662 24654 29414 266607 81666 25414 360820 309242 81757 500863 366275 303181 286994 309081 306400 361251 362271 299802 499918 303412 498233 296121 313589 312781 498997 288669 54225 65046 317576 25238 682507 314641 79121 25490 29491 29699 24679 690825 100912034 252857 680149 296472 60371 24697 116561 24952 245986 29241 78971 361373 116563 83800 140694 25751 81732 24176 303351 303251 84357 361597 310738 25108 246217 140898 310460 361223 78966 84009 310635 368044 361921 64373 303634 363509 307098 309512 296603 304109 687105 114559 117020 293024 302415 100362710 366957 292750 363460 81663 310192 290794 85384 312937 316009 308578 140670 297518 361120 25387 116664 64566 25388 436582 54241 311030 81645 116743 83615 498798 299971 311254 308190 24221 65201 310621 307505 25679 246331 25262 685451 362044 309159 171529 287624 29417 64465 353233 25521 83427 64199 103694380 25289 25725 25051 114120 64532 114118 293508 114119 114117 59326 25636 79218 65165 25496 56761 406162 25608 84392 314906 84391 362186 29492 315298 291983 26954 171109 24514 246145 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 58854 102552659 170668 29425 65179 24408 154985 25167 64030 64562 287871 24716 24410 24412 56718 117281 24446 301518 498576 29675 298514 29671 29670 29376 24968 24967 29372 310903 690919 25704 112400 29666 24337 24329 117263 117262 116663 364814 290206 24592 103694903 246273 64022 161475 60445 360814 24703 64226 83499 24245 24244 338457 25267 309179 29614 29496 29211 689852 64363 24497 652957 116630 140924 114103 24246 24855 289257 84423 361992 84422 29668 81745 303605 29495 25614 292766 691318 25266 363131 362572 310091 360573 100362634 60427 24672 309168 81827 24673 297176 24482 292887 288924 171081 24242 291245 296072 29630 81511 81530 296651 408248 297960 304893 24483 24586 25746 301574 308666 360854 24172 307821 24856 116551 690198 85492 116643 363875 246358 25233 83613 290291 312754 83803 24185 29516 65248 300980 66023 25525 25326 360776 314612 305203 312664 25136 65052 432361 287716 114858 58960 501146 192126 29542 192213 83840 25467 192117 295357 364052 246150 315648 305614 299147 78975 288589 25400 25150 100909655 117044 59323 25344 171140 84598 170577 117043 59325 25433 25435 25676 310533 366508 500985 25493 689314 362896 81771 308267 363520 113894 498003 24498 100912585 315305 89829 114509 301059 287942 309361 289014 81646 309165 84351 102551184 294429 266761 299706 100360868 680097 292085 117098 295277 24600 100912489 117056 364723 312495 103693372 287830 25520 102548682 116555 100360950 683983 500351 81738 679983 102557184 89813 171576 64515 29499 314352 499241 25506 361831 361662 84477 289874 311324 362891 314384 29554 313121 298942 25124 25125 289950 362418 100363500 361765 84492 315139 311245 25205 25155 25156 171379 100910771 317546 361565 315994 24918 501560 54245 291159 116554 367264 362356 54237 100911248 63881 81515 296849 691496 117269 287280 50646 81654 309295 362491 60587 309957 MAPK FAMILY SIGNALING CASCADES%REACTOME DATABASE ID RELEASE 60%9438025 MAPK family signaling cascades 291983 171109 24514 246145 289924 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 58854 102552659 170668 84482 29425 65179 24408 25167 64030 24716 24410 24412 117281 24446 498576 29675 294515 29671 29670 29376 24968 24967 29372 690919 25704 112400 29666 24337 24329 117263 117262 116663 364814 290206 24592 103694903 64022 161475 360814 24703 83499 24245 24244 25267 309179 29614 29496 295234 29211 689852 64363 24497 652957 116630 140924 114103 24246 303353 289257 84423 84422 29668 29495 25614 292766 691318 25266 362572 360573 60427 24672 309168 365388 81827 24673 288924 171081 24242 94198 291245 296072 29630 81511 296651 408248 304893 24586 25746 116590 307821 29432 50689 100910732 85492 363875 83613 312754 300980 66023 25525 25326 314612 305203 312664 25136 432361 287716 114858 58960 192126 29542 192213 25467 192117 364052 246150 315648 305614 299147 288589 25400 25150 59323 25344 171140 84598 170577 498183 59325 25433 25676 310533 310806 64156 24498 50522 25581 89807 89804 84009 83805 681260 85252 64159 498837 24471 100912032 29431 29433 362045 313838 361505 361195 25193 58840 360635 56011 54268 309175 79114 81504 170633 83806 170700 313845 54250 287670 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 25114 25022 29368 116499 25622 60662 85385 170582 25205 24525 66017 60464 29669 64465 293508 361384 25636 54237 29677 29672 287772 287984 311078 HYDROLYSIS OF LPE%REACTOME%R-RNO-1483152.1 Hydrolysis of LPE 691810 691813 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%R-RNO-69273.1 Cyclin A B1 associated events during G2 M transition 25203 171150 295052 24672 24673 266713 682033 315648 117104 85252 84389 287101 171103 361643 103694903 361613 362817 171102 114494 54237 307511 308937 58921 117281 AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME DATABASE ID RELEASE 60%9437982 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 24297 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 60%9437770 Cell Cycle, Mitotic 289924 299331 691979 680014 303353 360161 365388 94198 81754 299557 114483 100910954 317425 116590 85242 301323 246327 94201 307641 116549 50689 54238 25164 301701 298594 304813 286993 308443 100911204 362548 681050 317252 25023 684439 294712 304951 304477 56082 246294 298850 362504 501706 29167 287598 363028 363174 691493 289150 305270 83572 361416 116659 315164 295661 299850 291441 681185 25448 316425 296137 257649 257644 117103 116670 29648 366275 498310 114514 311327 306464 303037 307511 24708 362485 114851 83571 25729 304740 114482 308064 305467 683722 252921 287101 499933 171102 499655 294790 308937 25203 24679 304218 314949 25581 63996 290577 29486 305343 313304 315958 290668 361836 100362333 299112 680006 304573 399489 100909750 311562 682033 291105 117104 311860 81758 684111 83806 287670 500545 114592 362965 293733 81650 64041 65201 29669 362044 171529 287624 362763 25255 64465 292787 305171 85265 689523 306102 314642 58921 29677 29672 300126 287772 291137 292071 287984 311078 84391 362186 315740 291983 24514 289990 58854 29425 117281 29675 295052 29671 29670 24968 24967 29666 117263 117262 364814 290206 103694903 161475 362817 114494 83499 309179 29614 689852 29668 292766 691318 307639 499914 24672 81827 24673 297176 296368 360643 498030 290842 292058 305420 293155 29630 296651 408248 362980 692032 306594 307169 300149 361308 103690018 362798 60336 113961 287447 60334 29214 291914 310511 100360828 498266 307821 171103 361643 361613 29380 406168 362203 287929 306599 308663 308870 309098 301252 85492 680991 691918 361634 680477 312754 305909 24185 305882 29479 64462 293844 100911033 300963 363055 311546 81740 315423 367153 24669 500069 291540 25594 294010 287716 690209 311191 192228 64158 316531 309692 296554 100362495 311529 305288 311802 311573 313977 286919 360672 299730 58822 310344 83836 103690034 261730 290626 305002 246150 315648 114764 311886 299147 29213 60347 313048 171150 303024 116468 288003 302661 292263 310806 360908 362304 25737 301430 84389 316273 64156 295596 289758 59102 300947 50522 680111 297893 89809 689820 100360427 58919 361178 102551184 116651 53372 81513 294429 300259 299706 680097 292085 117021 304862 295277 84490 100912489 364723 58958 83805 245922 113929 24680 65274 681260 85252 287830 304528 84576 102548682 116555 362281 25281 100360950 683983 295692 500351 291874 81738 59294 499974 313138 296178 300084 287524 29728 679983 291927 113975 498837 307126 360621 266713 312538 361698 287961 313479 102557184 100912032 29685 291885 25497 362335 288532 296883 288414 84593 100911727 171576 290875 361389 64515 296558 29753 291689 366381 311412 100360936 361831 56010 304490 361662 100359528 65158 678726 361765 25437 114087 60374 361907 362779 315330 64193 684771 295107 362356 362519 54237 305392 363481 81515 287280 170845 307805 360886 297522 363059 CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 60%9438965 Cysteine formation from homocysteine 24250 24962 103691744 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 60%9438157 Peptide chain elongation 29565 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 60%9438237 Toll Like Receptor TLR6:TLR2 Cascade 303024 116590 25493 689314 363855 314322 81771 308267 363520 64156 291912 498003 296390 50689 25272 117281 314384 313121 287398 50522 500133 100912585 679539 315305 305549 114509 81647 301059 81649 362418 305451 305835 116663 100363500 309361 361765 289014 81646 103694903 309165 315139 311245 84351 114495 100910771 317546 50658 361565 300980 300447 100912399 116596 116667 303200 315994 100912618 681260 501560 116554 24516 362356 81722 287707 24672 309452 24673 498837 315648 117269 116725 100912032 287280 309295 81736 362491 25742 60587 305751 309957 81525 304859 54226 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 60%9437845 Amino acid synthesis and interconversion (transamination) 304429 24957 81670 300384 287877 296350 25721 293820 300035 24399 64313 85309 362428 25612 311844 361755 364064 79251 307759 24401 289727 58835 G-PROTEIN ACTIVATION%REACTOME DATABASE ID RELEASE 60%9438084 G-protein activation 365901 363143 25601 25740 24400 50664 25686 81664 29190 24664 25643 286924 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 60%9438655 Amine ligand-binding receptors 53949 60448 24316 25432 24318 65032 103694905 24175 29238 25111 29581 29595 25083 25645 24260 25187 25229 25323 25324 25075 85268 29413 24473 29412 25461 25689 170704 64354 24176 24448 81645 25195 302619 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 60%9437785 Switching of origins to a post-replicative state 291983 24708 114851 83571 289924 289990 58854 307821 362304 29425 301430 64156 316273 295596 83806 287670 29675 295052 50522 29671 29670 24968 25581 24967 29666 117263 117262 364814 290206 362817 161475 85492 114494 83499 29614 29669 689852 303353 681260 287716 29668 292766 314642 29677 29672 313138 296178 365388 29728 81827 291927 498837 360621 312538 287772 313479 100912032 29685 292071 291885 288532 287984 311078 94198 29630 296651 408248 ANTIMICROBIAL PEPTIDES%REACTOME%R-RNO-6803157.1 Antimicrobial peptides 688047 117029 408247 305354 246238 305842 299606 24854 192264 308163 84387 301034 310553 683849 296290 24620 302422 29692 24941 299567 613221 308873 25052 498659 641627 613225 290257 83687 50585 116547 100361909 84355 54303 474169 311559 497195 102554637 24932 316519 498284 100361866 286958 295180 24691 103690254 24258 499658 685161 170496 286995 362347 296321 103694852 314615 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%R-RNO-1799339.1 SRP-dependent cotranslational protein targeting to membrane 103692785 140655 287417 360572 292964 64156 367865 103690821 367265 116650 100910180 294282 29236 296076 100360647 100911575 140662 100364265 291685 100360841 690345 103690015 363707 684988 691531 140661 64640 100360057 29283 367195 100360619 29284 100911847 103692831 81729 28298 100360679 26962 498351 64302 103693375 290641 689284 362041 100360117 296709 103694404 317646 29288 81767 29282 81763 100360522 81768 81765 81769 64205 311120 681260 301299 100362830 690468 314652 81775 81770 29752 64638 81776 25348 306079 103694169 65139 297756 498837 100912182 300079 100912032 25347 682793 100910370 685963 124440 306926 687780 29258 100359922 161477 65043 25538 499782 100361079 SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 60%9439072 SUMOylation of DNA damage response and repair proteins 301442 497672 308669 309595 309995 313961 314949 297561 299957 83422 300772 315713 287662 293967 361645 362827 63996 29486 313304 53372 25591 315958 294429 300259 299706 292085 114521 117021 304862 308755 58958 245922 113929 65274 287830 312560 25573 116555 362281 25281 683983 295692 291874 81738 499974 313038 287524 113975 25497 362335 362581 309626 304850 303730 303731 501403 310258 499417 84593 307151 312690 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 60%9438994 NOTCH1 Intracellular Domain Regulates Transcription 297767 500695 679028 25496 303101 54244 AMINE OXIDASE REACTIONS%REACTOME DATABASE ID RELEASE 60%9438134 Amine Oxidase reactions 501620 308652 293589 29253 25750 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 60%9437870 Death Receptor Signalling 100910771 683206 317546 100362554 246244 353233 308267 83427 103694380 681260 60383 64156 687813 361167 364386 64044 312937 266610 246775 313121 50522 25385 246097 117279 311786 246756 60371 57027 498837 100912032 78971 94193 306886 311401 361373 308493 309361 309295 94338 315139 84351 83537 100911911 81859 362828 LDL REMODELING%REACTOME%R-RNO-8964041.1 LDL remodeling 85253 54225 CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 60%9437801 Cellular Senescence 362485 114851 83571 25729 689314 363855 314322 81771 64156 25272 295052 287398 50522 83712 100912585 114509 289014 362817 300711 102551184 114494 64046 100360868 680097 85482 295277 100912489 117056 364723 681260 103693372 102548682 100360950 500351 679983 498837 296368 360643 498030 102557184 100912032 305420 293155 314856 304798 290875 114483 361389 100910954 64012 116590 296558 291689 366381 311412 100360936 310511 361831 304490 304063 94201 25261 50689 24356 292721 54238 25164 81649 114495 302935 94165 363849 294408 50658 690237 100911837 361403 362078 303200 500054 315994 307861 501560 297758 291159 307798 116554 24516 314642 361798 290232 313038 365057 315136 691496 117269 362581 309626 304850 293104 312299 303730 303731 116484 501403 498183 304569 310258 313048 303259 24253 363630 307151 312690 ION HOMEOSTASIS%REACTOME DATABASE ID RELEASE 60%9438119 Ion homeostasis 24245 367086 24244 361618 25679 25262 140447 140448 64190 294141 24246 58950 29693 63847 683667 29600 24598 63848 64672 29639 308405 89821 81678 116831 24215 25560 24213 24211 24214 24212 29598 25400 689560 29599 24242 83535 171140 25650 25391 29132 59299 25390 362013 29715 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 60%9437784 Orc1 removal from chromatin 291983 24708 114851 83571 289924 289990 58854 307821 362304 29425 301430 64156 316273 295596 83806 287670 29675 295052 50522 29671 29670 24968 25581 24967 29666 117263 117262 364814 290206 362817 161475 85492 114494 83499 29614 29669 689852 303353 681260 287716 29668 292766 314642 29677 29672 313138 296178 365388 29728 81827 291927 498837 360621 312538 287772 313479 100912032 29685 292071 291885 288532 287984 311078 94198 29630 296651 408248 DNA REPAIR%REACTOME DATABASE ID RELEASE 60%9437821 DNA Repair 65179 295052 295704 114212 362817 300711 114494 288079 156826 498749 289757 259171 85245 100359600 298693 311944 301128 361767 29722 290907 313539 360748 313027 363251 64557 497976 499870 100910954 100361529 64012 303375 685055 291787 498411 294800 310034 497672 497856 315969 368002 293452 498119 299638 689055 298884 316235 297486 302953 306257 102551085 171366 363247 293678 362288 287634 116643 293489 305073 313387 688845 362412 360847 361181 84478 171150 289561 294693 116468 497967 304343 288003 103690054 245976 301442 298508 364834 361365 303369 287367 308669 363283 100147704 312710 309595 300795 289508 500225 25737 290631 291526 361815 84389 140639 64156 316794 494338 292778 292101 500987 690966 289758 261736 301382 313098 103692172 59102 290997 363273 362704 361107 308415 288651 293494 287927 50522 310707 691642 307766 81822 502227 362394 246216 307905 300813 314061 117017 89809 298012 83503 298074 360471 300222 291905 296084 303193 315523 102551184 24919 25591 81513 291703 29240 290805 362600 64046 100362315 363924 315344 29541 499966 680097 306734 308576 114521 301014 85482 367090 81528 83507 305957 84490 295277 100912489 680915 304577 308755 24561 364723 79116 360254 170841 361836 362479 681260 498109 100361574 312560 304528 366163 25573 102548682 100360950 64470 500351 100911295 292673 59294 363633 300084 679983 287524 310071 498837 266713 361698 361925 116725 102557184 100912032 100362121 360915 305600 65137 499155 296883 84495 501552 303742 291737 306274 360704 100912534 294236 100360594 302502 288414 316440 498453 499417 361580 25019 84593 100911727 316344 309643 313702 24361 361435 292127 309256 102555079 309812 502320 100909750 311860 309995 297561 362827 100360342 81685 81709 301000 499505 116554 296099 289468 680537 REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME DATABASE ID RELEASE 60%9439140 Regulation of TLR by endogenous ligand 499985 305354 54225 305353 100365047 103690020 60350 29260 29469 310553 29184 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME DATABASE ID RELEASE 60%9438405 Synthesis of Dolichyl-phosphate 311847 294400 298541 296624 305291 81726 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%R-RNO-4641262.1 Disassembly of the destruction complex and recruitment of AXIN to the membrane 83721 293990 64512 24881 303181 58868 308692 293649 679110 291678 25404 312781 303251 303811 PROTEIN REPAIR%REACTOME%R-RNO-5676934.1 Protein repair 361286 680036 116484 29447 ACROSOME REACTION%REACTOME%R-RNO-1300645.1 Acrosome Reaction 24163 SERINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 60%9438872 Serine biosynthesis 304429 296350 293820 58835 FMO OXIDISES NUCLEOPHILES%REACTOME%R-RNO-217271.1 FMO oxidises nucleophiles 246245 25256 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME%R-RNO-380270.1 Recruitment of mitotic centrosome proteins and complexes 362980 692032 29753 304740 302661 114482 29214 308064 305467 683722 56010 252921 362203 287929 306599 308663 308870 117281 299331 309098 25203 24679 680991 691918 361634 362504 680477 29167 305909 305882 29479 64462 293844 100911033 300963 363055 83572 81740 315423 367153 116659 500069 291540 294010 690209 311191 192228 64158 299850 316531 309692 296554 100362495 311529 305288 311802 311573 54237 286919 360672 299730 58822 310344 83836 103690034 290626 305002 246150 114764 311886 29213 60347 84593 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME%R-RNO-196849.1 Metabolism of water-soluble vitamins and cofactors 361185 100911394 64365 683849 291939 367323 25668 361819 85496 83578 361472 315085 25052 305889 688517 29527 361751 293504 24778 100912521 362134 24312 84594 81522 297508 499330 499328 25527 353255 300886 103690254 751787 289095 29142 290947 305248 287379 303676 362347 680308 100125370 246046 298653 408247 361300 299857 116719 170551 311655 50622 24624 294972 50621 58813 365699 299699 25035 302422 680668 680432 289175 361884 500820 288240 309465 25104 303333 81506 303905 301221 316062 300691 25732 295229 64001 313520 315023 299196 54349 64533 102554637 64392 311536 314459 29723 100911034 80848 363069 362942 296167 300328 103690044 24691 103689921 298490 294088 287711 687861 50671 362653 362851 64300 362657 294753 CELLULAR RESPONSE TO HYPOXIA%REACTOME%R-RNO-2262749.1 Cellular response to hypoxia 291983 289924 289990 361831 58854 25242 307821 29425 64156 83806 54244 287670 29675 50522 29671 29670 24968 25581 24967 29666 64345 308457 117263 117262 64525 81807 364814 81920 24874 290206 29560 54702 161475 85492 83499 29614 114490 29669 689852 316101 361258 29452 303353 681260 287716 29668 292766 641452 29677 309434 29672 365388 300084 81827 498837 287772 100912032 287984 311078 94198 29630 296651 408248 NEGATIVE REGULATION OF MET ACTIVITY%REACTOME DATABASE ID RELEASE 60%9439256 Negative regulation of MET activity 24446 84357 50522 500985 498837 117063 24697 29645 100912032 681260 64156 81504 312574 311030 296121 116743 498798 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 60%9438309 Downregulation of TGF-beta receptor signaling 59086 29357 50522 498837 100912032 81810 287155 681260 25631 311676 64156 83837 29591 287607 103690035 297699 NUCLEAR ENVELOPE BREAKDOWN%REACTOME DATABASE ID RELEASE 60%9439062 Nuclear Envelope Breakdown 25437 300259 114087 299706 60374 362779 292085 117021 304862 287447 291914 58958 245922 113929 24680 65274 360161 287830 116555 362281 25281 683983 54237 313977 295692 25203 291874 81738 499974 113975 25497 362335 25023 53372 294429 VITAMINS B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME DATABASE ID RELEASE 60%9438859 Vitamins B6 activation to pyridoxal phosphate 64533 361819 83578 54349 RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT.%REACTOME DATABASE ID RELEASE 60%9438758 Rhesus glycoproteins mediate ammonium transport. 293048 310625 65207 PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 60%9438457 PI3K AKT Signaling 114851 366508 83571 24628 24629 314641 361696 294048 64545 102552659 84482 24954 64030 50686 79240 24506 24505 294235 56718 84027 117281 24446 294515 365367 29376 59265 690919 112400 24337 24329 310131 309361 140607 103694903 81646 246273 64022 296648 64226 25267 29741 309179 29496 85243 83805 24855 361992 81745 302415 691318 25266 58918 60427 24672 24673 365865 292887 314856 309419 116590 79114 81504 170633 50689 25513 89812 170700 54250 25443 25444 170579 314850 25317 170583 29348 29349 84489 361388 25114 25022 29368 116499 25622 100363500 60662 170582 66017 25156 60464 25233 312754 24185 50557 432361 56822 25408 25660 29414 25467 315648 299147 25150 59323 59325 25433 TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME DATABASE ID RELEASE 60%9439246 TP53 Regulates Transcription of Death Receptors and Ligands FCERI MEDIATED CA+2 MOBILIZATION%REACTOME DATABASE ID RELEASE 60%9438278 FCERI mediated Ca+2 mobilization 313845 24244 29748 25679 81515 363577 25262 81678 311658 100361818 295378 361400 25738 296603 24242 29337 85385 81511 84492 81504 155918 25155 24674 25156 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 60%9439052 Condensation of Prometaphase Chromosomes 307641 116549 295107 362519 81650 305392 RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 60%9438098 Release of apoptotic factors from the mitochondria 25309 100360940 100363502 288753 ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME DATABASE ID RELEASE 60%9438558 ABC transporters in lipid homeostasis 363516 286970 25270 84356 302973 155192 85264 300664 114628 299609 83519 25081 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190372.1 FGFR3c ligand binding and activation 54250 29368 116499 25444 60662 366061 25317 170583 29349 84489 66017 60464 HS-GAG DEGRADATION%REACTOME DATABASE ID RELEASE 60%9438974 HS-GAG degradation 316033 360630 116673 25615 58920 25216 691984 64537 25592 360904 171517 24434 317322 24771 VASOPRESSIN-LIKE RECEPTORS%REACTOME DATABASE ID RELEASE 60%9438636 Vasopressin-like receptors 29462 25108 24221 25107 25504 100909648 25342 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 60%9438853 IRAK2 mediated activation of TAK1 complex 308267 362418 681260 100910771 313121 50522 317546 64156 498837 315139 311245 100912032 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 60%9438630 Regulation of IGF Activity by IGFBP 289560 171154 54225 24765 25473 361676 25434 59107 63880 303635 116635 83727 25353 300060 315108 24498 79110 117036 63878 25641 362862 503164 79438 25662 29237 308807 100911615 363455 25312 56646 680415 192152 313262 298941 83501 85253 59302 89842 338474 25728 24233 25296 360622 304917 25685 288001 25649 25277 304334 24903 25285 24482 24825 100909521 100909524 84491 24483 54226 64366 25373 300445 362859 25506 79224 79210 303743 296290 83725 84595 288038 29160 290257 25615 362182 170583 24259 29251 114122 367252 298683 114031 25081 313770 25661 361969 24367 29417 24232 689404 60333 289525 292485 298296 292905 500221 83476 300339 81686 24268 25376 64312 406161 361029 58935 103689965 29461 78965 301013 24177 116510 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 60%9438249 Fcgamma receptor (FCGR) dependent phagocytosis 288669 116590 308666 360854 682507 100909750 310178 65261 311860 309014 81504 50689 25513 299331 301252 25734 81678 81822 79113 25738 170538 100911825 81732 103693683 24884 363875 25155 300678 25156 684969 360620 360426 29741 58823 25300 25679 25262 85243 116591 289211 64465 83805 296603 313024 54245 300955 25614 289820 287876 498276 317371 65172 295279 301009 304966 81515 679934 79249 295378 297518 303073 299354 29431 25150 309081 361251 362271 54227 315348 117542 100361457 259242 25097 117538 EPH-EPHRIN SIGNALING%REACTOME%R-RNO-2682334.1 EPH-Ephrin signaling 288669 360854 682507 24408 81687 29491 24410 362513 299331 25615 293621 81822 289231 83785 25589 79208 81732 316539 29210 366492 24884 363875 684969 298528 310643 312279 84358 94268 246217 171287 60589 84009 64465 83805 296603 304109 114559 289820 25614 287876 83841 81762 81515 297173 25537 295378 306636 297518 25186 361882 24338 81686 501203 287989 29431 29433 25150 316369 100911293 360546 300802 691658 54227 81751 365872 100361457 292788 25676 TRAIL SIGNALING%REACTOME DATABASE ID RELEASE 60%9437957 TRAIL signaling 266610 246775 117279 64044 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME%R-RNO-975138.1 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation 303024 116590 25493 689314 317468 684440 363855 314322 81771 308267 363520 64156 291912 498003 296390 50689 25272 117281 314384 313121 287398 50522 500133 100912585 679539 315305 305549 114509 81647 301059 81649 362418 305451 305835 116663 100363500 309361 361765 289014 81646 103694903 309165 315139 311245 84351 114495 338457 100910771 317546 50658 361565 300980 300447 100912399 116596 116667 303200 315994 100912618 681260 501560 116554 24516 362356 81722 287707 24672 300177 309452 24673 498837 315648 117269 116725 100912032 287280 309295 81736 362491 25742 60587 305751 309957 81525 304859 54226 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%R-RNO-264870.1 Caspase-mediated cleavage of cytoskeletal proteins 83527 499156 29477 25402 83584 64204 24170 81818 64026 296654 64159 103689977 64044 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME%R-RNO-156584.1 Cytosolic sulfonation of small molecules 58953 64076 24902 297433 306866 117267 171072 312952 25355 100910057 360268 288617 288719 295443 316153 503103 294103 300983 501103 24912 64305 361510 83783 100910526 64473 292915 103689950 367201 CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME DATABASE ID RELEASE 60%9439303 Carboxyterminal post-translational modifications of tubulin 362415 690512 298692 299208 310982 NICOTINAMIDE SALVAGING%REACTOME%R-RNO-197264.1 Nicotinamide salvaging 300691 29527 367323 25527 361751 295229 297508 361185 500820 315085 303905 316062 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME%R-RNO-6804114.1 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 25203 25737 25112 313017 261730 298795 54237 24887 RECYCLING OF EIF2:GDP%REACTOME%R-RNO-72731.1 Recycling of eIF2:GDP 117019 296302 54318 64514 171145 192234 299027 ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME%R-RNO-114294.1 Activation, translocation and oligomerization of BAX 64625 24887 UB-SPECIFIC PROCESSING PROTEASES%REACTOME%R-RNO-5689880.1 Ub-specific processing proteases 291983 84478 171329 297593 289924 25493 501659 304150 85471 289990 290864 310960 311807 288482 289717 58854 29425 64156 298534 171102 294790 303539 308896 314453 302488 29675 295052 50522 100910107 29357 297989 29671 115771 100912059 29670 60371 24968 25581 360819 24967 307905 313427 117519 310306 291796 29666 78971 363445 117263 117262 361373 25631 364814 362414 290206 304579 100361658 29560 360471 266601 24176 114558 161475 312688 303201 362636 114494 303351 83499 29240 29614 689852 408217 303353 309512 681260 361015 688466 363084 29668 311856 361190 302415 29591 100190936 499801 292766 309153 363164 290794 312937 103690035 689730 365388 81827 498837 100912032 100362121 65137 25388 94198 29630 296651 408248 311030 314856 304798 100910954 64515 293345 171152 307821 83806 287670 361749 313121 65138 315139 85492 311245 140593 361634 100910771 29669 50557 287716 29677 29672 311786 287772 287984 306886 293705 311078 309295 315911 296121 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 60%9438722 Sodium-coupled phosphate cotransporters 81826 29502 246234 25548 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 60%9438244 Toll Like Receptor 5 (TLR5) Cascade 303024 116590 25493 689314 363855 314322 81771 308267 363520 64156 291912 498003 296390 50689 25272 117281 314384 313121 287398 50522 500133 100912585 679539 315305 305549 114509 81647 301059 81649 362418 305451 305835 116663 100363500 309361 361765 289014 81646 103694903 309165 315139 311245 84351 114495 100910771 317546 50658 361565 300980 300447 100912399 116596 116667 303200 315994 100912618 681260 501560 116554 24516 362356 81722 287707 24672 309452 24673 498837 315648 117269 116725 100912032 287280 309295 81736 362491 25742 60587 305751 309957 81525 304859 54226 HEDGEHOG 'OFF' STATE%REACTOME DATABASE ID RELEASE 60%9439150 Hedgehog 'off' state 291983 287612 307724 303968 289924 688749 113927 54223 302661 289990 100362124 140588 140589 58854 361769 503018 307821 305509 29425 59320 64156 293047 312651 25273 64508 289180 84420 83806 362265 308577 29699 24679 287670 29675 50522 29671 29670 24968 24967 25581 29666 29241 117263 117262 364814 361765 290206 161475 85492 83499 29614 29669 689852 303353 25521 681260 25289 287716 25725 29668 64532 292766 293508 362356 25636 29677 29672 365388 300084 81827 302950 498837 304729 295654 287772 305918 305349 287280 100912032 89830 287984 84392 311078 94198 29630 296651 408248 MET ACTIVATES PI3K AKT SIGNALING%REACTOME%R-RNO-8851907.1 MET activates PI3K AKT signaling 24446 81504 25513 361388 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 60%9437800 DNA Damage Telomere Stress Induced Senescence 64046 362485 114851 100910954 83571 302935 25729 64012 94165 680097 363849 690237 294408 85482 100911837 295277 361403 100912489 364723 500054 307861 297758 307798 102548682 100360950 500351 290232 295052 679983 102557184 304569 362817 102551184 300711 114494 ALPHA-OXIDATION OF PHYTANATE%REACTOME DATABASE ID RELEASE 60%9438645 Alpha-oxidation of phytanate 85255 300083 114209 65192 65183 METABOLISM OF SEROTONIN%REACTOME DATABASE ID RELEASE 60%9438135 Metabolism of serotonin 29253 29539 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 60%9437837 Hexose uptake 300259 299706 65197 292085 117021 304862 294321 25552 170580 58958 245922 113929 65274 287830 25634 116555 362281 25281 683983 295692 291874 81738 499974 303565 113975 24385 25059 25497 362335 304785 25351 25139 25658 303205 295245 24778 53372 500973 294429 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 60%9438718 NoRC negatively regulates rRNA expression 500351 100360868 680097 679983 295277 100912489 691496 117056 364723 102557184 103693372 680172 291159 102548682 102551184 100360950 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 60%9438876 Activation of G protein gated Potassium channels 29712 29713 170847 25743 690825 24400 117052 83633 116560 680149 60449 81667 81657 245986 114120 116649 50599 114118 114119 114117 29719 79218 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%R-RNO-111453.1 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 24224 64547 492821 246142 64625 64639 SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 60%9438624 Serotonin Neurotransmitter Release Cycle INTERLEUKIN-1 PROCESSING%REACTOME%R-RNO-448706.1 Interleukin-1 processing 24494 309452 309165 29197 81736 25166 ACETYLATION%REACTOME DATABASE ID RELEASE 60%9438167 Acetylation 290681 116631 116632 RRNA PROCESSING%REACTOME%R-RNO-72312.1 rRNA processing 64156 100360057 367195 100360619 100911847 81729 100359574 114021 290556 309628 688637 316317 317399 289740 310720 289810 314713 300050 100360664 314545 313744 313167 103689953 103692785 309301 293828 361977 287417 85432 360572 100912375 292964 363134 367865 362967 103690821 362703 291987 362902 299198 305258 287120 288647 303245 360574 367265 100910180 25135 360828 100911575 679140 140662 313581 300045 313243 100364265 313707 295050 100360841 363237 294975 303456 362229 298065 366017 305076 140661 314617 361159 64640 309458 316098 29283 297685 308441 690297 29284 317579 103692831 289724 28298 362214 686999 26962 361262 64302 296865 60373 103693375 290660 290641 312706 689284 365668 362041 314830 292747 100360117 296709 103694404 317646 81767 29282 81763 100360522 81768 81765 81769 64205 311120 301299 100362830 300092 690468 314652 81770 64638 306079 103694169 315697 310019 100912182 300079 25347 682793 100910370 685963 124440 306926 29258 100359922 65043 499782 100361079 INHIBITION OF HSL%REACTOME%R-RNO-164928.1 Inhibition of HSL 29516 ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 60%9439019 Abacavir transmembrane transport 29503 29504 24904 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 60%9437842 Pyruvate metabolism 24534 29554 54705 24533 80878 298942 296849 25682 25246 116551 117098 25027 29634 289950 294320 81654 25271 24439 311254 81530 307852 89813 65200 SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 60%9438700 Surfactant metabolism 314799 245977 246326 24773 29316 362859 25369 652957 494021 192155 24175 171081 302973 29597 25083 60575 25548 499766 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME DATABASE ID RELEASE 60%9439063 SUMO is conjugated to E1 (UBA2:SAE1) 308384 301442 308508 ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME DATABASE ID RELEASE 60%9439270 ERBB2 Activates PTK6 Signaling 24329 366275 102552659 432361 59323 29496 64022 690919 59325 25433 112400 24337 IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME%R-RNO-1606341.1 IRF3 mediated activation of type 1 IFN 292892 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME DATABASE ID RELEASE 60%9438148 Aflatoxin activation and detoxification 24297 300981 171341 26760 94199 289197 252931 25642 293653 171445 171352 100910877 MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 60%9438733 mRNA decay by 3' to 5' exoribonuclease 679140 360629 300045 313243 295050 294975 366017 316098 308441 363064 294595 266605 293408 ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME%R-RNO-8963889.1 Assembly of active LPL and LIPC lipase complexes 24539 24538 116548 25507 360495 54281 100361444 362850 300027 PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME DATABASE ID RELEASE 60%9439275 PTK6 Regulates Proteins Involved in RNA Processing 366275 117268 64015 170843 POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 60%9439329 Post-translational protein phosphorylation 289560 171154 54225 24765 25473 361676 25434 59107 63880 303635 116635 83727 25353 300060 315108 24498 79110 117036 63878 362862 503164 29237 100911615 308807 363455 25312 56646 192152 298941 83501 59302 89842 338474 25728 24233 25296 360622 304917 25685 288001 25649 25277 304334 24903 25285 24825 100909521 100909524 84491 54226 64366 25373 300445 25506 79224 362859 79210 303743 296290 83725 84595 288038 29160 25615 362182 170583 24259 114122 298683 367252 114031 25081 313770 25661 361969 24367 29417 24232 689404 60333 289525 292485 298296 292905 500221 83476 25376 24268 64312 406161 361029 58935 103689965 29461 78965 301013 24177 116510 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 60%9438691 P2Y receptors 310444 117264 63843 317219 64803 29597 302378 171108 691774 767613 25265 FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME%R-RNO-173599.1 Formation of the active cofactor, UDP-glucuronate 289827 83472 298280 DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME%R-RNO-5610780.1 Degradation of GLI1 by the proteasome 291983 289924 289990 58854 140589 361769 307821 29425 64156 83806 287670 29675 50522 29671 29670 24968 25581 24967 29666 117263 117262 364814 290206 361765 161475 85492 83499 29614 29669 689852 303353 681260 287716 29668 292766 362356 29677 29672 300084 365388 81827 498837 287772 100912032 287280 287984 311078 94198 29630 296651 408248 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME%R-RNO-400508.1 Incretin synthesis, secretion, and inactivation 294075 302813 171101 266607 685451 25040 60449 24952 25253 25608 286924 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 60%9437781 G1 S Transition 24708 291983 171150 362485 114851 83571 289924 25729 289990 58854 360908 362304 301430 84389 29425 316273 64156 295596 171102 59102 499655 294790 308937 117281 29675 50522 295052 29671 29670 24968 24967 25581 29666 117263 117262 103694903 161475 362817 58919 114494 83499 29614 689852 303353 681260 29668 292766 24672 313138 365388 296178 287524 81827 29728 291927 24673 307126 498837 266713 360621 312538 287961 313479 100912032 29685 291885 288532 296883 94198 29630 296651 408248 100362333 299112 304573 85242 301323 682033 246327 307821 94201 83806 287670 85492 24185 29669 287716 362356 29677 29672 287772 315648 287280 292071 287984 366275 311078 REGULATION OF DNA REPLICATION%REACTOME%R-RNO-69304.1 Regulation of DNA replication 291983 24708 114851 83571 289924 399489 311562 289990 291105 58854 307821 362304 29425 301430 64156 316273 684111 295596 83806 287670 29675 295052 50522 29671 29670 24968 24967 25581 29666 117263 117262 364814 290206 362817 161475 85492 114494 83499 29614 29669 689852 303353 681260 287716 29668 292766 314642 29677 29672 313138 296178 365388 29728 81827 291927 307126 498837 360621 312538 287772 291137 313479 100912032 29685 292071 291885 288532 287984 311078 94198 29630 296651 408248 REGULATION OF COMPLEMENT CASCADE%REACTOME DATABASE ID RELEASE 60%9438606 Regulation of Complement cascade 24854 298288 445269 295703 84007 24236 24235 113959 24233 24232 24237 313421 312705 155012 365466 294257 365367 498241 24231 289395 362119 303861 29251 298566 192262 299354 81750 289057 29687 113936 406161 29333 103689965 25621 29169 296545 54243 25407 KETONE BODY CATABOLISM%REACTOME DATABASE ID RELEASE 60%9437918 Ketone body catabolism 25014 690163 CHOLINE CATABOLISM%REACTOME DATABASE ID RELEASE 60%9438968 Choline catabolism 114123 290551 245961 291450 CLATHRIN DERIVED VESICLE BUDDING%REACTOME%R-RNO-421837.1 Clathrin derived vesicle budding 64678 317576 306332 313409 24803 81803 140673 192243 116561 83800 25751 64310 192152 252929 25319 29292 365191 100360087 367038 361459 366618 367304 304344 360785 100362805 100362547 302671 366311 29663 171575 287709 689955 683687 89816 310746 302290 81659 291464 311404 295217 288785 25387 689256 312689 360515 83730 641528 309451 680476 309969 363476 362609 312694 296199 85491 25151 25306 361632 83576 81917 294900 54241 317630 364183 100909548 116743 289312 54226 TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME DATABASE ID RELEASE 60%9438927 TWIK-related alkaline pH activated K+ channel (TALK) 688996 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 60%9438248 Role of phospholipids in phagocytosis 360426 304966 29741 25300 25679 25262 81678 85243 116591 289211 299354 25738 170538 100911825 309014 103693683 25513 498276 25155 25097 295279 300678 NOSIP MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 60%9438506 NOSIP mediated eNOS trafficking 292894 24600 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 60%9438590 Recycling pathway of L1 292139 81637 308578 65046 25416 116590 54319 171574 140670 83805 84393 116563 83800 50687 140694 25751 54241 25744 116743 MACROAUTOPHAGY%REACTOME%R-RNO-1632852.1 Macroautophagy 26954 362045 312634 64562 287871 56718 301518 298514 114558 60445 308869 64226 308846 305831 365191 288498 83803 100359937 64670 171415 65248 295234 360776 24855 312927 65052 361916 140734 305482 362164 363278 364419 360827 282834 303630 679886 64862 689161 58974 300240 363131 59319 362245 310091 100361543 287873 295357 363720 363254 312647 361321 688555 78975 100909655 117044 117043 297960 PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME%R-RNO-428559.1 Proton-coupled neutral amino acid transporters 155205 246235 VITAMIN E%REACTOME DATABASE ID RELEASE 60%9439311 Vitamin E 25571 METABOLISM OF FOLATE AND PTERINES%REACTOME DATABASE ID RELEASE 60%9438452 Metabolism of folate and pterines 64392 24312 303333 29723 64300 299857 362657 305248 287379 361472 299699 680432 680308 315023 300886 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 60%9438060 Signaling by NGF 289924 25369 361696 294048 64545 84482 24954 50686 59109 79240 24506 24505 294235 84027 294515 365367 59265 170820 170538 140607 295234 84006 295347 303353 365388 84578 365865 94198 314856 116590 25402 50689 24596 83765 315691 362548 171574 50557 29414 81757 29622 29613 116478 25054 116546 300078 294376 291713 114851 83571 65046 64547 25238 314641 29491 29699 24679 24681 25581 29241 116563 83800 140694 25751 310738 246217 140898 310460 64314 361223 78966 84009 310635 361921 303634 363509 307098 296603 304109 687105 114559 117020 293024 100362710 302415 64159 292750 363460 310192 85384 308578 29691 140670 54241 116743 309419 81637 362045 89812 83806 287670 289231 81649 25679 25262 29669 25521 25289 25725 64532 293508 56822 25636 29677 25408 25660 29672 297173 287772 287984 311078 81736 291983 171109 24514 246145 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 58854 102552659 170668 29425 65179 24408 25167 64030 24716 24410 24412 56718 117281 24446 498576 29675 29671 29670 29376 24968 24967 29372 690919 25704 112400 29666 24337 24329 117263 310131 117262 116663 364814 290206 24592 103694903 246273 64022 161475 296648 360814 24703 64226 83499 24245 24244 25267 309179 29614 29496 29211 689852 64363 24497 652957 116630 140924 114103 24246 24855 289257 84423 361992 84422 29668 81745 29495 25614 292766 691318 25266 362572 360573 60427 24672 309168 81827 24673 292887 288924 171081 24242 291245 296072 29630 81511 296651 408248 304893 24586 25746 25050 307821 81678 85492 363875 25233 83613 312754 24185 300980 66023 25525 25326 314612 305203 312664 25136 432361 287716 114858 58960 192126 29542 192213 25467 192117 364052 246150 315648 305614 299147 288589 25400 25150 59323 25344 171140 84598 170577 59325 25433 25676 310533 366508 25493 689314 54223 81771 363520 305509 113894 64156 498003 64508 84420 50522 100912585 450224 315305 29409 360678 297893 114509 301059 287942 309361 289014 81646 54281 309165 84351 89807 29741 89804 85243 24166 83805 24680 681260 117089 58918 301334 310999 362648 304193 290541 311647 498837 309653 295378 100912032 116548 25507 100911293 300802 691658 81751 365872 292788 29753 56011 64639 79114 81504 170633 25513 170700 313845 314384 54250 25443 25444 170579 316213 293621 314850 25317 57027 170583 29348 29349 84489 24605 361388 25125 25114 25738 25022 362418 29368 116499 25622 100363500 60662 85385 170582 311245 24525 66017 60464 25156 361565 24225 315994 81737 25730 501560 54245 84469 116554 100911248 63881 302950 117269 362491 83537 60587 309957 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 60%9438152 G2 M Transition 291983 303024 171150 114851 289924 304740 302661 289990 114482 308064 305467 683722 252921 58854 29425 84389 64156 287101 171102 117281 308937 299331 25203 24679 29675 295052 50522 29671 29670 24968 25581 24967 29666 117263 117262 364814 290206 103694903 362817 161475 114494 83499 29614 689852 303353 681260 85252 29668 292766 24672 300084 365388 81827 24673 498837 266713 100912032 94198 29630 296651 408248 84593 362980 692032 100910954 29753 682033 29214 117104 56010 307821 100359528 171103 361643 361613 29380 406168 362203 287929 306599 308663 83806 308870 309098 287670 304813 301252 678726 361765 85492 246294 680991 691918 361634 362504 29167 680477 305909 305882 361907 29479 64462 29669 293844 100911033 300963 363055 311546 83572 81740 315423 367153 116659 85265 500069 291540 25594 294010 690209 287716 306102 311191 192228 299850 64158 316531 309692 296554 100362495 311529 362356 305288 311802 54237 311573 286919 58921 29677 360672 299730 58822 29672 310344 300126 83836 103690034 261730 290626 305002 287772 246150 315648 114764 311886 287280 29213 287984 117103 60347 116670 311078 307511 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 60%9438582 Peptide ligand-binding receptors 192649 192648 64636 171101 29385 308163 100124593 84007 50577 25616 25380 117027 25726 25723 24889 29538 360750 24938 171371 360579 54305 287730 690230 287673 29234 292413 301066 497196 29237 292419 60337 292409 378939 171104 25605 25107 287910 25593 25108 54258 192206 192205 25007 113959 500157 681706 60628 24323 24324 299757 259222 24326 259224 64042 288001 114492 25601 84475 690158 24903 84348 29256 24772 171551 81638 60665 29310 366274 29462 24180 24182 366270 25706 310327 29190 25033 29471 24179 379044 24664 54226 25354 78964 100909783 25555 59301 445269 81503 362454 295144 294807 25524 24808 24677 29141 24806 24807 116498 690198 25516 29251 25570 25439 29636 24604 25569 305236 171044 297795 362505 24221 171054 362506 83518 497942 246358 24613 25504 29363 25635 25298 81509 363682 100360071 298006 29180 282839 81780 114105 50672 24232 282832 116677 114215 289023 29191 84022 499194 266997 301086 57305 685243 29335 363866 64107 63850 58812 24797 117549 246759 362119 360918 100909648 66024 688605 245920 246075 171056 89808 316019 29358 94204 63887 497078 25245 103690156 252939 25340 297025 408243 24659 25342 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%R-RNO-170670.1 Adenylate cyclase inhibitory pathway 24611 25686 302950 81664 54223 25643 29241 25289 305509 64532 64508 84420 286924 ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 60%9438044 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway 29240 79116 LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-RNO-5632681.1 Ligand-receptor interactions 683470 29499 50938 291936 89830 SALM PROTEIN INTERACTIONS AT THE SYNAPSES%REACTOME DATABASE ID RELEASE 60%9439277 SALM protein interactions at the synapses 25252 365222 83764 360406 29629 316205 29628 313278 688721 308495 24408 140945 29495 24410 58948 24412 PLC-MEDIATED HYDROLYSIS OF PIP2%REACTOME DATABASE ID RELEASE 60%9438114 PLC-mediated hydrolysis of PIP2 500336 25155 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME DATABASE ID RELEASE 60%9438995 Regulation of innate immune responses to cytosolic DNA 313264 50522 498840 299827 498837 314336 292892 100912032 499069 681260 64156 292545 293774 308901 FCGR ACTIVATION%REACTOME%R-RNO-2029481.1 FCGR activation 304966 25300 81515 25734 79113 116591 289211 83805 299354 25150 100911825 103693683 24884 498276 25155 295279 300678 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 60%9438011 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 24158 117543 29740 ESTROGEN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 60%9438421 Estrogen biosynthesis 289456 25322 286921 691018 296972 79243 25147 116463 KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 60%9438784 KSRP (KHSRP) binds and destabilizes mRNA 24185 103690064 679140 300045 313243 295050 294975 171137 366017 100909830 291604 316098 308441 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%R-RNO-2173795.1 Downregulation of SMAD2 3:SMAD4 transcriptional activity 29357 50522 365894 498837 114208 499929 297893 100912032 361831 363445 681260 25631 81920 64156 360801 84576 641452 25591 316742 RSK ACTIVATION%REACTOME DATABASE ID RELEASE 60%9438756 RSK activation 317203 501560 116590 81745 117269 81771 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME%R-RNO-163680.1 AMPK inhibits chREBP transcriptional activation activity 100362634 289036 25520 64562 312670 246253 171078 78975 ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME DATABASE ID RELEASE 60%9439160 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 500351 100360868 680097 679983 29355 295277 83724 100912489 691496 117056 364723 102557184 103693372 291159 102548682 102551184 500569 100360950 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME%R-RNO-400511.1 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 302813 266607 25040 25253 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 60%9438728 Platelet sensitization by LDL 89788 81649 54225 81662 24653 81666 79113 362558 309242 CD22 MEDIATED BCR REGULATION%REACTOME%R-RNO-5690714.1 CD22 mediated BCR regulation 308501 RETINOID METABOLISM AND TRANSPORT%REACTOME%R-RNO-975634.1 Retinoid metabolism and transport 307092 54225 171516 116673 58920 25592 292697 25680 24539 25728 171517 286921 291283 24856 25702 25649 300027 362757 25615 24710 315644 25056 362558 25216 691984 25703 296972 55939 64047 299858 114106 116463 191574 317322 24771 25081 ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME DATABASE ID RELEASE 60%9439051 Antagonism of Activin by Follistatin 29200 24373 114031 MITOCHONDRIAL TRANSLATION%REACTOME%R-RNO-5368287.1 Mitochondrial translation 114017 294696 364656 310653 289469 293754 290632 299743 311903 295238 293666 497876 296995 361037 309176 301240 297727 287962 300974 363023 297334 103691922 103693219 293149 363646 296551 683519 298517 297459 309140 287126 294963 367117 362517 290850 688912 363187 295224 309440 288621 288916 361883 113958 291206 289143 498406 64360 360594 301371 294672 297799 299938 362216 293054 680747 296134 689025 289491 303673 362094 171061 301250 299628 361473 361005 100361098 301552 287356 500199 301352 297372 294767 362388 691075 297601 303685 303746 287635 294230 292244 499185 292758 301249 100910528 56281 100363539 103692169 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME%R-RNO-68689.1 CDC6 association with the ORC:origin complex 362304 313138 301430 296178 295596 684111 291927 399489 360621 311562 313479 291105 CLEARANCE OF DOPAMINE%REACTOME%R-RNO-379401.1 Clearance of dopamine 24267 308868 24898 29253 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 60%9437834 Pentose phosphate pathway (hexose monophosphate shunt) 362706 83688 690945 287479 24377 64524 501157 290636 289632 362383 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%R-RNO-1793185.1 Chondroitin sulfate dermatan sulfate metabolism 294673 116673 314694 316533 58920 293722 25592 25227 364675 171517 367166 691394 25615 361450 25216 691984 58982 25181 360904 64544 291577 64134 292999 29139 286974 84468 50568 298690 114122 500257 365583 304322 317322 297865 25393 81651 296733 291770 306375 300757 302302 24771 297554 NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 60%9439080 Negative regulation of activity of TFAP2 (AP-2) family transcription factors 306862 25573 301442 362280 301285 SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME%R-RNO-4551638.1 SUMOylation of chromatin organization proteins 301442 84577 501145 316164 83422 300772 297893 287662 363287 102551184 53372 294429 300259 299706 680097 292085 117021 304862 295277 100912489 364723 58958 245922 113929 65274 287830 84576 25573 102548682 116555 362281 25281 100360950 683983 295692 500351 291874 81738 499974 313038 679983 113975 102557184 25497 362335 362581 309626 304850 303730 303731 501403 310258 499417 307151 312690 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 60%9438537 Synthesis of Leukotrienes (LT) and Eoxins (EX) 56266 25290 299732 286904 503122 94199 289014 114097 290623 81639 29624 REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-RNO-975574.1 Reactions specific to the hybrid N-glycan synthesis pathway 29582 VEGFA-VEGFR2 PATHWAY%REACTOME DATABASE ID RELEASE 60%9438251 VEGFA-VEGFR2 Pathway 291983 171109 24514 246145 289924 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 58854 102552659 170668 29425 65179 24408 25167 64030 24716 24410 24412 56718 362513 117281 299331 24446 498576 29675 29671 29670 29376 24968 24967 29372 690919 25704 112400 29666 24337 24329 117263 310131 117262 116663 170538 364814 290206 24592 103694903 246273 64022 161475 296648 360814 24703 64226 83499 24245 24244 25267 309179 29614 29496 29211 295234 689852 64363 24497 652957 116630 140924 114103 24246 303353 289257 84423 361992 84422 29668 81745 29495 25614 292766 691318 25266 362572 360573 60427 24672 309168 365388 81827 24673 288924 171081 24242 291245 94198 296072 29630 81511 296651 408248 304893 24586 25746 308666 116590 307821 29432 50689 81678 500904 100910732 83785 25023 25589 85492 363875 83613 312754 58823 24185 300980 66023 25525 25326 29302 314612 305203 312664 25136 432361 287716 313024 25404 114858 58960 307618 192126 29542 679934 192213 79249 25467 192117 364052 25414 246150 360820 315648 303073 311163 305614 299147 288589 25400 25150 309081 59323 361251 25344 362271 171140 84598 117542 170577 59325 114553 25433 25676 310533 689314 64156 50522 25581 289014 89807 29741 89804 85243 24600 83805 171119 24680 29513 296603 681260 60352 300955 64159 25522 25537 498837 295378 24471 100912032 29431 29433 316369 315348 362045 66021 56011 79114 81504 170633 25513 83806 170700 313845 287670 54250 25443 25444 170579 310688 316213 308444 293621 314850 25317 170583 29348 29349 84489 24605 25114 25738 81649 25022 29368 116499 60662 85385 170582 24525 66017 25156 60464 307505 25679 25262 29669 81679 64465 315994 54245 81762 29677 29672 297173 287772 50646 79129 287984 311078 RHO GTPASES ACTIVATE PAKS%REACTOME%R-RNO-5627123.1 RHO GTPases activate PAKs 24244 64465 100911597 25594 102551071 296313 29432 65172 304813 293860 685867 308572 100910732 362816 116670 29431 24582 29433 24242 288057 25745 100909726 304447 100910474 25744 363875 685883 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 60%9438683 Free fatty acids regulate insulin secretion 29322 89788 81662 24654 266607 81666 309242 IRS ACTIVATION%REACTOME DATABASE ID RELEASE 60%9437934 IRS activation 498416 29376 25467 24954 24506 24505 VISUAL PHOTOTRANSDUCTION%REACTOME DATABASE ID RELEASE 60%9437930 Visual phototransduction 307092 54225 171516 24400 295500 79222 301233 498869 316218 25539 499132 59077 363143 25680 29481 286921 83579 24856 25702 81644 289878 25615 680149 353252 259274 688297 313689 307401 299858 317322 310836 89810 25081 266761 24244 116673 58920 25318 25592 292697 24539 171517 25728 291283 25649 300027 362757 24710 315644 25056 25216 362558 691984 296972 25703 55939 64047 114106 116463 116556 81760 291318 191574 64511 24242 89826 140936 24711 317498 85259 266714 293049 314264 83686 363071 24771 SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME DATABASE ID RELEASE 60%9438977 Synthesis of PIPs at the ER membrane 116482 315422 300147 305419 CD28 CO-STIMULATION%REACTOME DATABASE ID RELEASE 60%9438455 CD28 co-stimulation 24185 116596 64465 83805 361992 81745 81504 29432 25513 56822 56718 25408 360640 25660 81515 100910732 29431 25150 310131 29433 310695 246273 296648 24884 363875 64226 25156 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%R-RNO-997269.1 Inhibition of adenylate cyclase pathway 24611 25686 302950 81664 54223 25643 29241 25289 305509 64532 64508 84420 286924 MITOPHAGY%REACTOME%R-RNO-5205647.1 Mitophagy 300075 192647 681123 83529 299514 304017 685620 298575 308416 83805 64476 681260 113894 360827 64156 64862 307641 116549 362245 50522 100911485 363442 288731 498837 100912032 81650 361321 266601 PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME%R-RNO-964827.1 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 294410 295319 362625 RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME DATABASE ID RELEASE 60%9439119 RHO GTPases Activate NADPH Oxidases 65052 114243 366957 311793 292279 302976 114553 363875 66021 363131 500904 79129 HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME DATABASE ID RELEASE 60%9439087 HSP90 chaperone cycle for SHRs 362504 689955 29167 301252 65028 252902 84026 81655 29564 367808 192277 290798 84428 362809 116659 140734 260321 308961 361810 299850 25154 300721 299331 ATP SENSITIVE POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 60%9438910 ATP sensitive Potassium channels 25472 83535 25559 25560 MISCELLANEOUS SUBSTRATES%REACTOME%R-RNO-211958.1 Miscellaneous substrates 56266 286904 503122 310848 290623 308445 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%R-RNO-1296072.1 Voltage gated Potassium channels 64358 65195 25468 29682 296395 84020 66022 365241 298908 25470 307900 246153 65198 117018 25469 117023 25327 24520 114032 171011 83588 307234 60326 58981 117101 29731 117105 29738 171146 29737 294065 170848 295360 27150 116745 116695 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME DATABASE ID RELEASE 60%9438808 Acetylcholine binding and downstream events 170945 25102 25101 171131 25590 25302 65024 29422 81721 25103 54240 54239 79557 HDL REMODELING%REACTOME%R-RNO-8964058.1 HDL remodeling 292697 25728 85264 291437 296371 24530 25081 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 60%9439106 Depolymerisation of the Nuclear Lamina 25437 25203 24680 60374 25023 287447 291914 54237 313977 SIGNALING BY FGFR3%REACTOME%R-RNO-5654741.1 Signaling by FGFR3 116590 500985 366061 306141 500526 83805 681260 64156 79114 81504 170633 50689 25513 170700 117281 313845 54250 25443 25444 24672 50522 170579 316213 293621 24673 314850 25317 498837 170583 29348 29349 84489 100912032 24605 361388 25114 25738 25022 29368 116499 25622 60662 85385 170582 103694903 24525 66017 60464 VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME%R-RNO-432040.1 Vasopressin regulates renal water homeostasis via Aquaporins 25108 24400 685451 54223 60449 81667 25521 64199 25289 305509 25725 81830 294962 114120 64532 83579 114118 64508 293508 114119 84420 114117 25636 79218 29699 24679 308003 25132 690825 25293 100912034 680149 302950 245986 29241 25240 24221 PI5P REGULATES TP53 ACETYLATION%REACTOME%R-RNO-6811555.1 PI5P Regulates TP53 Acetylation 298696 100910954 364298 290744 89812 114495 HEME DEGRADATION%REACTOME DATABASE ID RELEASE 60%9438168 Heme degradation 24861 79239 154516 301595 292737 574523 396527 113992 396552 24451 396551 116599 ACTIVATION OF TRKA RECEPTORS%REACTOME DATABASE ID RELEASE 60%9438227 Activation of TRKA receptors 24225 81737 25730 310738 25369 29613 25054 59109 24166 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME DATABASE ID RELEASE 60%9438842 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 103692785 140655 287417 360572 292964 64156 367865 689116 103690821 100912571 367265 100910180 294282 29236 100360647 100911575 140662 100364265 100360841 103690015 684988 691531 140661 64640 100360057 29283 367195 100360619 29284 100911847 103692831 81729 28298 100360679 26962 64302 103693375 290641 689284 362041 100360117 296709 103694404 317646 29288 298075 24420 81767 29282 81763 100911685 100360522 684558 81768 81765 81769 64205 307503 311120 681260 301299 291615 100362830 690468 501582 314652 81775 81770 29752 64638 81776 25348 306079 103694169 65139 297756 498837 100912182 300079 100912032 25347 682793 100910370 685963 124440 306926 687780 29258 100359922 161477 65043 25538 499782 100361079 TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME%R-RNO-8878159.1 Transcriptional regulation by RUNX3 314856 291983 100910954 289924 361630 289990 58854 307821 29425 64156 361391 679028 83806 54244 287670 59086 29675 50522 29671 690516 29670 297767 24968 25581 24967 29666 117263 117262 25631 161475 85492 58919 363287 24525 83499 29614 29669 689852 83805 303353 681260 287716 29668 294276 500695 292766 303101 29677 29672 365388 81827 498837 100909544 25496 307829 287772 100912032 287984 311078 363014 94198 29630 296651 408248 SIALIC ACID METABOLISM%REACTOME%R-RNO-4085001.1 Sialic acid metabolism 25547 313139 83505 363103 298071 362924 29204 24591 103690047 363040 316033 312826 29758 114711 311530 296370 25197 304860 303692 25280 64442 407765 407764 287920 316642 301155 64445 304023 116696 364901 117185 PHOSPHORYLATION OF EMI1%REACTOME DATABASE ID RELEASE 60%9438326 Phosphorylation of Emi1 25203 64515 314642 292263 54237 METALLOTHIONEINS BIND METALS%REACTOME DATABASE ID RELEASE 60%9439194 Metallothioneins bind metals 117038 ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-RNO-139910.1 Activation of BMF and translocation to mitochondria 140734 246142 116554 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 60%9438131 Formation of Fibrin Clot (Clotting Cascade) 65051 691992 116669 100911551 24366 116727 362248 502858 24946 29681 25259 79224 361969 289055 295703 83580 24367 290757 306761 100909700 499099 304917 302470 29366 288001 24903 100911545 29251 25439 360918 81750 29436 293118 260320 25048 60327 25584 24153 314615 PURINE CATABOLISM%REACTOME%R-RNO-74259.1 Purine catabolism 83585 497811 311422 361274 313574 361068 287406 363129 100360582 298881 171047 290365 58813 305149 290029 117260 100363253 TRIGLYCERIDE CATABOLISM%REACTOME%R-RNO-163560.1 Triglyceride catabolism 140868 64822 363471 79451 25598 300108 25330 25062 24669 25594 25629 24668 79131 80841 25440 499570 293508 316130 29254 24360 25404 25636 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME DATABASE ID RELEASE 60%9438409 Synthesis of bile acids and bile salts 307092 171516 303497 79111 83724 365410 313929 79244 252898 25429 83569 362360 170588 291283 296461 65192 81924 25428 246211 362782 298369 301264 25284 309527 191574 311129 25271 29725 60351 192242 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 60%9437852 Neuronal System 24957 25550 83612 24408 24410 24412 84429 170567 445371 65272 100909725 688996 499303 64120 116489 29553 116491 59324 170899 24703 25297 24245 24244 290567 60442 24246 29642 79213 79212 81745 29495 85426 100911769 84591 84016 59317 366432 24242 291245 81632 497009 85327 291133 314856 29712 29713 170847 25743 117052 24400 25472 116590 116560 276720 25686 81664 60449 81667 25643 81657 29629 29627 60355 361568 29628 25050 317203 29559 60341 54257 116649 50599 83817 29253 29539 286924 29503 25553 24267 308868 24898 25023 25559 83613 170945 25102 116600 25101 171131 25590 25302 65024 25103 81721 54239 79557 29322 24654 24380 24379 192213 246150 25400 171140 29613 50688 64358 65195 25468 29682 65046 296395 83633 116470 54263 84020 66022 365241 65206 29747 54223 298908 25470 54262 307900 81771 66016 54261 305509 114245 24803 114244 64508 65198 117018 84420 310303 25469 58942 117023 25716 25327 64832 24520 114032 362876 293645 171011 64830 690825 83588 680149 24681 140592 307234 140591 245986 84556 29241 29708 60326 65187 58981 117101 29709 29731 29707 117105 116563 84390 171146 81646 29737 24947 294961 294065 83731 170848 295360 27150 116745 29719 116695 140675 50564 29695 313126 25451 29705 289606 140724 140725 29694 192258 25450 309349 24680 306147 313278 140729 688721 308495 308918 84347 140945 29422 54240 308578 24611 310519 365222 25560 83764 140670 308571 306152 266706 290467 360406 25531 312855 316205 83535 315435 81637 29483 83527 315840 50676 293621 257648 685472 286923 294380 116681 100363500 29738 171163 24414 29548 84012 116595 79146 29547 58948 29546 81859 64053 500219 25252 64353 313052 304733 25466 83589 171297 59312 679668 287609 83610 78957 65040 286930 24407 117096 298521 116724 553106 309557 103690160 171026 60377 54234 29647 25289 25558 24409 501560 116647 246212 114120 60391 64532 246153 114118 293508 56064 114119 114117 79218 689955 302950 116638 117269 79130 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%R-RNO-2129379.1 Molecules associated with elastic fibres 313662 287382 252835 59107 25717 29302 311061 25296 83838 362429 293677 29373 59086 292734 287299 315191 85272 364786 81809 102553715 362800 305604 29169 282583 29158 METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME%R-RNO-5263617.1 Metabolism of ingested MeSeO2H into MeSeH 58819 DNA REPLICATION PRE-INITIATION%REACTOME%R-RNO-69002.1 DNA Replication Pre-Initiation 291983 100362333 299112 289924 304573 399489 311562 85242 289990 301323 291105 246327 58854 360908 307821 362304 29425 301430 64156 316273 295596 684111 83806 59102 287670 29675 50522 29671 29670 24968 24967 25581 29666 117263 117262 364814 290206 362817 161475 85492 83499 29614 29669 689852 303353 681260 287716 29668 292766 29677 29672 313138 296178 365388 29728 81827 287524 291927 307126 498837 360621 312538 287772 287961 313479 291137 292071 100912032 29685 291885 287984 288532 296883 311078 94198 29630 296651 408248 PROTEIN METHYLATION%REACTOME%R-RNO-8876725.1 Protein methylation 24244 689955 171361 689197 102553119 287054 89820 361664 290279 29565 24242 292845 316976 302931 PLASMALOGEN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 60%9437967 Plasmalogen biosynthesis 84114 84470 PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME DATABASE ID RELEASE 60%9438373 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes 24708 362485 25729 362817 ROS, RNS PRODUCTION IN PHAGOCYTES%REACTOME DATABASE ID RELEASE 60%9438697 ROS, RNS production in phagocytes 170667 297566 689779 24600 368044 66021 316519 117596 297797 291969 296981 29757 24599 24598 299159 297932 116455 366545 497963 289407 293650 362802 79129 500904 116664 94170 685232 436582 114553 299971 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 60%9438686 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) 363067 25747 312947 83724 116464 313929 84578 296732 365755 296474 25271 363026 360801 683381 497991 24360 54244 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME%R-RNO-446203.1 Asparagine N-linked glycosylation 364398 363103 296304 252902 24591 293721 24506 24505 64202 316033 287983 117263 171129 362031 499751 313139 29211 29403 362547 311204 289257 293129 25329 301012 289085 289994 367083 310411 171121 300674 361407 361207 100910318 293719 299075 361073 360475 300888 81519 309451 24390 94273 303652 29582 140568 293456 102555167 246117 116700 291990 116666 362599 79120 309144 100363782 295051 81754 498272 304978 25547 298541 83505 309010 84599 65134 298071 360709 361705 294410 432392 308511 140808 65271 361577 100912115 362625 60355 500251 100910557 363858 680465 306264 56042 89868 690252 310710 64154 171049 690961 362162 303100 54350 64351 360611 302972 29631 311847 140673 502017 361502 312826 25478 29758 363136 296394 114711 100360302 315345 311530 100909916 296370 302915 192243 29640 304860 25197 29183 300741 503165 297393 303692 58842 94189 81759 304543 24827 300089 297428 25280 308757 294400 296624 501550 360518 292074 309678 299346 290659 304954 287276 407765 362237 407764 367252 498486 287920 301155 297417 116643 116696 501167 295319 56082 364901 100126191 363109 362504 315000 29167 64462 81655 29564 290798 29144 84428 116659 313231 140734 308961 299850 305291 302470 305614 64156 246310 306570 50522 287427 298012 291095 293587 307848 300036 310935 100911225 65196 313536 362924 363040 681260 64159 498837 360967 100912032 288702 64442 407784 362912 494342 362275 303923 64445 304023 25407 300445 314352 295461 25423 362891 303702 297504 93646 294862 303244 24210 287275 252929 310843 29204 103690047 685144 58817 81726 300668 315212 65165 114023 297522 316642 361014 117185 84508 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 60%9438688 Sema4D mediated inhibition of cell attachment and migration 361568 297173 306400 362993 363875 306790 316009 SIGNALING BY NOTCH4%REACTOME%R-RNO-1980150.1 Signaling by NOTCH4 100911293 300802 691658 84010 81751 365872 311332 406162 292788 289231 29146 PTK6 ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 60%9439271 PTK6 Activates STAT3 366275 89829 363334 25125 SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME DATABASE ID RELEASE 60%9438987 Synthesis of IPs in the ER lumen 29688 ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME DATABASE ID RELEASE 60%9437849 Astrocytic Glutamate-Glutamine Uptake And Metabolism 170567 24957 29483 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 60%9438543 Notch-HLH transcription pathway 29492 297767 500695 679028 25496 56761 406162 303101 54244 TRANSPORT AND SYNTHESIS OF PAPS%REACTOME DATABASE ID RELEASE 60%9438332 Transport and synthesis of PAPS 64076 294103 306866 501103 117267 295443 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 60%9438512 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 93646 295461 287276 685144 287275 297522 24812 58817 80897 24811 25217 24223 64202 310843 103689996 SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 60%9438847 Spry regulation of FGF signaling 24672 50522 116590 500985 24673 498837 306141 500526 100912032 83805 681260 25622 64156 103694903 81504 50689 117281 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-RNO-141430.1 Inactivation of APC C via direct inhibition of the APC C complex 171576 290875 361389 64515 297176 296558 296368 291689 360643 366381 498030 311412 100360936 361831 305420 304490 361662 293155 MEIOSIS%REACTOME DATABASE ID RELEASE 60%9438836 Meiosis 365155 LYSOSOME VESICLE BIOGENESIS%REACTOME%R-RNO-432720.1 Lysosome Vesicle Biogenesis 365191 367038 361459 366618 367304 304344 360785 100362805 306332 313409 100362547 302671 366311 171575 29663 24803 689955 310746 116561 311404 25387 288785 312689 83730 83800 85491 25751 64310 54241 100909548 116743 252929 54226 PI-3K CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 60%9438356 PI-3K cascade:FGFR2 54250 25443 25444 170579 314850 25317 170583 29348 29349 361388 25022 29368 116499 25622 60662 81504 170633 25513 66017 170700 60464 P75NTR SIGNALS VIA NF-KB%REACTOME DATABASE ID RELEASE 60%9438428 p75NTR signals via NF-kB 310738 50522 24596 25493 498837 84006 100912032 301059 362418 681260 363520 64156 113894 309165 362491 311245 81736 84351 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 60%9438240 Toll Like Receptor 9 (TLR9) Cascade 303024 116590 25493 689314 317468 684440 363855 314322 81771 310461 308267 363520 64156 314764 291912 312562 498003 296390 50689 25272 117281 314384 313121 50522 287398 500133 100912585 679539 315305 305549 114509 81647 301059 81649 362418 305451 305835 116663 100363500 309361 361765 289014 81646 103694903 309165 315139 311245 84351 114495 338457 100910771 317546 50658 361565 300980 300447 100912399 116596 116667 303200 315994 65052 100912618 681260 501560 116554 24516 362356 363131 81722 287707 24672 300177 309452 24673 498837 315648 117269 116725 287280 100912032 309295 81736 362491 25742 60587 305751 309957 81525 304859 54226 INTERLEUKIN-4 AND 13 SIGNALING%REACTOME DATABASE ID RELEASE 60%9438774 Interleukin-4 and 13 signaling 287287 24514 25124 362896 25326 140924 25125 100361294 500616 252963 100360218 25084 171060 84598 367264 116553 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 60%9438051 Signaling by GPCR 103693566 64636 293262 25360 366844 289924 366843 308163 25369 366816 100124593 246254 691774 296037 366109 366103 293268 246219 100912408 29238 25111 293091 293289 25380 81821 117027 25726 25723 24889 293255 25370 360750 500927 293083 293271 292794 293278 360579 54305 294138 293281 29234 293085 293285 688730 301066 497196 293279 29237 690572 170538 25107 287910 308875 684170 25593 293435 295834 24419 287322 684171 365523 295234 287324 362384 684179 287321 287329 287328 25194 287325 366151 303353 287310 117264 64803 25310 681706 287313 25329 405239 100911893 287314 259222 405233 259224 64042 25187 287316 300414 29446 117257 500460 309962 690158 84348 29256 365388 363993 295827 300400 295822 295828 363710 103692138 295829 300408 366802 29462 366112 366111 293402 170704 25706 94198 293400 295801 310327 100909438 29471 116700 690334 315452 24664 366100 100910500 292324 100310881 25354 117029 100310886 100310885 25555 116590 363761 363762 363763 309222 293425 300640 366116 366115 366114 293424 295863 293429 294190 293817 295865 293815 293421 24808 29290 295869 24806 24807 50689 294187 294186 293810 287309 300639 100310879 100310878 405242 405249 100310875 405248 293812 366123 100310877 100310876 294394 84583 25570 24604 25569 405252 294198 170926 295858 405258 297795 364275 294197 405218 684376 300643 405219 24415 25195 24613 24416 363546 100912958 25635 25637 81509 311180 405114 363549 405108 293399 405107 293398 29180 311179 293392 293394 103694905 311173 311175 81780 103693363 405106 405105 100910049 300395 24260 103690375 117064 100911586 289023 29191 81779 266997 301086 405287 25320 25321 301088 25323 25324 100911839 680188 295891 295890 362119 360918 405281 66024 114098 114099 679957 353250 300603 405293 314386 287331 100310880 295870 309212 103690156 25340 366377 24659 25342 293375 296675 404984 293377 293373 83633 293374 29385 404986 405131 405132 303296 84007 404978 404983 293379 296679 296678 405136 404977 56820 56821 405137 25616 405138 404976 296687 498475 100910009 288006 689936 405133 296689 405134 24241 338443 404999 404971 405115 404998 405112 690230 287673 56813 25581 502757 140928 292413 140929 404975 293389 293382 292419 404970 404969 404968 292409 25605 298947 404967 680358 405126 405121 502755 404981 293370 405125 405124 405123 24247 405122 89810 363585 405150 687088 103690410 100911398 690821 60448 100909831 406021 54258 24316 405166 365228 289240 405203 24318 405164 405160 289241 687097 100910928 113959 60432 60628 24323 24324 405179 24326 64159 405177 405178 406018 288001 289251 405175 404948 81744 399475 296682 405146 405148 405144 81743 171551 406004 406003 404943 60665 405140 100910719 405141 289261 293808 293809 404963 60451 293805 404962 404961 100363178 405158 81749 404960 296694 81752 405155 100909862 81753 310444 100912515 103693822 25666 362045 100910294 59301 686677 294203 302378 100909884 81503 100909683 295144 58965 294807 100909885 100910224 293336 293338 287613 287614 686660 25524 361076 25645 293334 289076 29141 100911348 293340 100910999 83806 293357 102553138 100912505 293327 287670 404797 100909894 293329 405185 405181 405180 293321 405183 405182 289254 100911796 289255 405171 289250 405174 305236 58966 25689 499149 58959 684683 362505 308776 100911380 362506 293316 293319 406039 500089 404794 100911376 24953 29363 25298 100912217 500347 100912327 100126231 29669 363826 100910599 298006 293761 100365887 293763 293764 293769 25265 300524 300525 501177 114105 287003 24232 367065 367064 295910 684208 293192 116677 100909578 293188 767613 298396 84022 81762 499194 29677 57302 57301 57305 29672 317219 297173 29335 363866 64107 85268 100910467 24797 293333 287772 64680 58949 246759 25652 25653 287984 100909648 314480 245920 311078 690448 301372 497931 29358 64354 497932 367745 293759 100909534 295900 25248 25245 293140 103693685 295907 500101 192649 192648 171101 300560 171519 301610 405362 100912374 405366 171108 103690011 25447 295786 405365 25449 65032 170816 100912540 50577 29581 292661 29597 29595 315571 287000 192646 25040 405373 295772 408199 295771 54248 295766 24938 171371 103690286 295769 295767 295768 25075 405344 405345 405346 405349 314904 287247 25461 287245 295781 378939 171104 405368 405352 295754 24929 103690299 287240 287241 25477 554302 103690280 287237 295751 295750 65275 299553 290493 305841 690472 295744 299242 304985 405391 405390 25026 303835 295712 25432 25024 295713 293773 295732 25007 24769 500157 171158 299570 300599 299757 295747 293781 295743 293789 295741 114492 293785 25229 299576 366668 84475 24903 295729 24772 54293 689869 24473 405966 81638 100911988 299596 59076 59075 366274 299586 287481 299588 366270 287480 690481 25029 405383 25033 405384 295721 379044 405386 287484 287487 288816 288813 404826 100910837 404828 405948 102555599 404825 405955 405963 362454 308408 404820 81657 59264 100911043 364306 408031 404814 25050 408030 404813 81648 404816 404818 24677 405969 100911035 24476 405003 24674 405970 405971 81644 405325 405326 365302 287973 404858 405917 405049 81678 405918 368088 405927 405940 25516 287970 288838 405928 405923 405934 404839 405935 286959 288181 288187 171054 287969 404832 83518 81668 24694 497942 302027 25504 405952 404861 405920 405921 404860 405331 287262 363682 100360071 405333 405050 100909966 405334 686967 405053 282839 405051 405919 405329 405337 50672 405911 288823 24668 100911479 282832 404859 114215 100912097 405912 405915 404855 405914 103690304 114211 404871 404875 290010 404876 405026 405303 405023 290018 58812 286913 365330 288858 59293 365327 365326 365323 289923 365324 100359873 63885 405907 405904 63887 63889 405056 404862 24448 404863 405057 100911670 50678 404877 404878 53949 404879 365334 365337 290009 405307 405312 290003 54223 365336 290001 405033 290005 406163 290006 404885 404887 290008 365340 305509 404891 404894 64156 100363053 405034 499860 404895 404898 64508 404897 100909796 84420 404888 29538 288879 290020 100912605 60590 288869 100910640 50522 287730 364979 288866 290050 304610 405065 405066 29555 405064 100361138 684539 60337 192223 63843 140866 290049 405071 85420 100910120 140595 100909493 288887 688705 499486 288886 293223 287506 288198 100911944 89807 293226 293224 89804 293221 288192 288190 287509 85243 363606 314649 298044 500317 60399 293210 66025 293211 192206 78979 306792 24166 192205 83805 78985 24680 287077 293218 681260 298040 305711 298042 293215 293214 309207 103693022 304289 78982 305795 78983 499913 78980 29254 78981 298038 298039 78984 302954 301334 310999 405990 405993 362648 24816 287088 304193 302045 290541 287080 311647 302958 25537 29316 309653 498837 287082 363639 29413 287081 29412 298046 295378 287086 405991 100912032 287084 287083 29310 298049 24180 103693054 24182 298045 100910876 405988 287513 100910162 405982 24179 287516 287090 497978 287517 687110 78964 29748 100909783 287093 405984 287514 405983 499237 405987 56011 405986 405985 79114 81504 170633 25513 170700 313845 54250 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 25114 25022 29368 116499 60662 85385 170582 295401 116744 498609 29733 29415 24525 66017 60464 302950 89823 24400 50664 25686 81664 60449 81667 25643 365901 282822 363143 25740 60395 294962 83579 286924 171044 24653 29322 89788 81662 24654 266607 81666 309242 25238 29491 29699 24679 690825 100912034 680149 24681 24952 245986 29241 24176 25108 246217 140898 310460 361223 78966 84009 310635 361921 64373 303634 363509 307098 296603 304109 687105 114559 117020 293024 100362710 366957 292750 363460 81663 310192 85384 316009 29749 25601 25638 29691 24611 360616 24626 290646 25387 25388 24627 29190 24675 140908 81645 445269 116498 29251 25439 29636 24221 24414 25679 25262 685451 25521 64199 25289 25725 25051 114120 64532 114118 293508 114119 114117 25636 79218 291983 171109 24514 246145 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 58854 102552659 170668 29425 65179 24408 25167 64030 24716 24410 24412 117281 24446 498576 29675 29671 29670 29376 24968 24967 29372 690919 25704 112400 29666 24337 24329 117263 117262 116663 364814 290206 24592 103694903 64022 161475 360814 24703 83499 24245 24244 25267 309179 29614 29496 29211 689852 64363 24497 652957 116630 140924 114103 24246 289257 84423 84422 29668 81745 29495 25614 292766 691318 25266 362572 360573 60427 24672 309168 81827 24673 288924 171081 24242 291245 296072 29630 81511 296651 408248 304893 24586 25746 307821 690198 85492 363875 246358 83613 312754 24185 29516 300980 66023 25525 25326 314612 305203 312664 25136 432361 287716 114858 679975 58960 685243 170896 192126 29542 192213 25467 63850 192117 288995 364052 170634 246150 117549 315648 367315 305614 29151 299147 29407 688605 60669 288589 25400 246075 25150 171056 89808 316019 292310 59323 25344 94204 171140 497078 84598 29625 170577 59325 252939 25433 297025 408243 25676 302619 310533 366508 81771 100912585 114509 81646 54226 84477 25031 100363500 25156 24175 501560 25083 117269 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 60%9437872 Phenylalanine and tyrosine catabolism 360719 24813 681913 64192 311844 29383 100360621 246307 24616 29531 29700 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 60%9438542 NICD traffics to nucleus 29492 297767 500695 679028 25496 56761 406162 303101 54244 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%R-RNO-1169091.1 Activation of NF-kappaB in B cells 291983 303024 289924 25493 289990 58854 307821 29425 64156 83806 287670 29675 50522 29671 29670 24968 25581 24967 29666 117263 117262 364814 309361 361765 290206 25023 309165 161475 316241 85492 84351 83499 305584 29614 29669 689852 303353 681260 287716 29668 292766 362356 29677 29672 365388 81827 498837 287772 100912032 287280 287984 311078 94198 309295 29630 296651 81736 408248 81525 DEPYRIMIDINATION%REACTOME DATABASE ID RELEASE 60%9438035 Depyrimidination 315344 29541 114521 367090 81528 305957 680915 304577 NUCLEOSOME ASSEMBLY%REACTOME%R-RNO-774815.1 Nucleosome assembly 298850 680097 289150 295277 305270 100912489 310511 364723 361416 315164 102548682 681185 316602 25448 100360950 500351 689399 681382 100911204 307766 679983 83712 689296 362548 102557184 65137 307805 311327 306464 684439 294712 313048 102551184 TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 60%9438605 Transmission across Electrical Synapses 50564 313126 266706 315435 DEGRADATION OF AXIN%REACTOME DATABASE ID RELEASE 60%9439097 Degradation of AXIN 291983 289924 29614 29669 689852 289990 303353 58854 309512 681260 307821 287716 29425 29668 64156 292766 290794 83806 29677 287670 29675 29672 50522 365388 29671 81827 29670 24968 498837 25581 24967 287772 100912032 29666 287984 117263 311078 117262 364814 94198 290206 29630 296651 161475 408248 85492 83499 SYNTHESIS OF PG%REACTOME DATABASE ID RELEASE 60%9438951 Synthesis of PG 303698 114101 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME%R-RNO-420597.1 Nectin Necl trans heterodimerization 192183 288124 498281 25066 360882 308417 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 60%9438169 Porphyrin metabolism 25374 79239 154516 304024 25709 29421 289219 691853 396552 116599 25748 361338 396551 24861 301595 292737 574523 396527 113992 309391 309070 24451 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%R-RNO-947581.1 Molybdenum cofactor biosynthesis 311655 361300 294753 84594 100911034 301221 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 60%9438383 FGFR1c ligand binding and activation 54250 29368 116499 25444 60662 79114 25317 170583 29349 66017 170700 HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME%R-RNO-3296197.1 Hydroxycarboxylic acid-binding receptors 353250 689936 SIGNALING BY HIPPO%REACTOME DATABASE ID RELEASE 60%9439003 Signaling by Hippo 25402 29753 56011 292994 65189 65157 308265 300289 363014 303039 297387 115769 313749 299116 295062 360920 311622 303251 MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME%R-RNO-68881.1 Mitotic Metaphase Anaphase Transition 292263 BICARBONATE TRANSPORTERS%REACTOME%R-RNO-425381.1 Bicarbonate transporters 24781 297386 295645 24780 117955 315311 266612 24779 312192 84484 SPERM MOTILITY AND TAXES%REACTOME%R-RNO-1300642.1 Sperm Motility And Taxes 680912 366174 290989 304485 362623 ATTENUATION PHASE%REACTOME DATABASE ID RELEASE 60%9439091 Attenuation phase 689955 260321 301252 286899 79245 367808 361384 362809 299331 54244 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME%R-RNO-176408.1 Regulation of APC C activators between G1 S and early anaphase 291983 171576 290875 361389 114851 64515 83571 289924 296558 291689 366381 289990 311412 100360936 292263 361831 304490 361662 58854 307821 29425 64156 83806 25203 287670 29675 295052 50522 29671 29670 24968 24967 25581 29666 117263 117262 364814 361765 290206 362817 161475 85492 114494 83499 29614 29669 689852 303353 681260 287716 29668 292766 314642 362356 54237 29677 29672 365388 81827 498837 297176 296368 360643 287772 498030 100912032 287280 305420 287984 293155 311078 94198 29630 296651 408248 ENOS ACTIVATION AND REGULATION%REACTOME DATABASE ID RELEASE 60%9438498 eNOS activation and regulation 24244 171128 25514 24185 682507 25523 24600 298184 29244 29498 29270 311111 64157 24242 297402 292894 25751 294239 25404 170520 299331 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME DATABASE ID RELEASE 60%9439027 MASTL Facilitates Mitotic Progression 307169 60336 60334 100360828 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 60%9438802 Role of second messengers in netrin-1 signaling 25738 114523 25311 TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME DATABASE ID RELEASE 60%9438007 TNFR1-induced proapoptotic signaling 306886 266610 361373 103694380 683206 311786 246756 312937 FERTILIZATION%REACTOME%R-RNO-1187000.1 Fertilization 24936 500052 680912 366174 290989 24163 304485 499152 362623 KERATAN SULFATE KERATIN METABOLISM%REACTOME DATABASE ID RELEASE 60%9438816 Keratan sulfate keratin metabolism 83717 316583 65196 294673 288752 313536 305571 362924 291015 84400 100911750 290638 64507 314771 363040 295934 290959 316033 24390 64442 367145 494342 362275 303923 307859 64445 304023 81682 300757 103690116 293667 SIGNAL AMPLIFICATION%REACTOME%R-RNO-392518.1 Signal amplification 89788 81662 24816 24400 81666 25686 81664 309242 25643 25265 83805 303634 81649 64803 24653 286924 INTERLEUKIN-2 SIGNALING%REACTOME%R-RNO-451927.1 Interleukin-2 signaling 291983 171109 24514 246145 289924 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 58854 102552659 170668 29425 65179 24408 25167 64030 24716 24410 24412 117281 24446 498576 29675 29671 29670 29376 24968 24967 29372 690919 25704 112400 29666 24337 24329 117263 117262 116663 364814 290206 24592 103694903 64022 161475 360814 24703 83499 24245 24244 25267 309179 29614 29496 295234 29211 689852 64363 24497 652957 116630 140924 114103 24246 303353 289257 84423 84422 29668 29495 25614 292766 691318 25266 362572 360573 60427 24672 309168 365388 81827 24673 288924 171081 24242 94198 291245 296072 29630 81511 296651 408248 304893 24586 25746 116590 307821 50689 85492 83613 312754 300980 66023 25525 25326 314612 305203 312664 25136 432361 287716 114858 58960 192126 29542 192213 25467 192117 364052 246150 315648 305614 299147 288589 25400 25150 59323 25344 171140 84598 170577 59325 25433 25676 310533 366508 64156 116689 50522 25581 89807 89804 85243 83805 681260 64159 498837 100912032 362045 56011 84477 79114 81504 170633 25513 83806 170700 313845 54250 287670 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 25114 25022 29368 116499 60662 85385 170582 24525 25155 66017 60464 29669 54259 24918 29677 29672 287772 50646 287984 311078 FATTY ACYL-COA BIOSYNTHESIS%REACTOME%R-RNO-75105.1 Fatty acyl-CoA biosynthesis 171410 681458 113976 679532 84013 289736 680115 83792 361802 94340 25288 29743 102549542 246074 114024 499018 498962 64669 50671 24159 117243 29411 301120 309449 359725 498728 191576 54398 499358 171400 171402 PACKAGING OF TELOMERE ENDS%REACTOME DATABASE ID RELEASE 60%9438345 Packaging Of Telomere Ends 500351 290232 680097 679983 690237 295277 361403 100912489 364723 102557184 500054 307861 297758 307798 102548682 102551184 100360950 MET RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 60%9439315 MET receptor recycling 24446 287942 54245 25532 81504 360658 361388 79121 100911248 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 60%9438471 NCAM signaling for neurite out-growth 291983 171109 24514 246145 289924 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 305104 364686 116562 306628 58854 102552659 170668 29425 65179 24408 25167 64030 24716 24410 24412 117281 24446 25454 498576 29675 29671 29670 29376 24968 24967 29372 690919 25704 112400 29666 24337 24329 117263 117262 116663 364814 290206 24592 103694903 64022 161475 360814 24703 83499 24245 24244 25267 309179 29614 29496 295234 29211 689852 64363 24497 652957 116630 140924 114103 24246 303353 289257 84423 362285 84422 29668 29495 25614 292766 691318 25266 362572 360573 60427 24672 309168 365388 81827 24673 290905 288924 171081 24242 94198 291245 296072 29630 81511 362584 296651 408248 304893 24586 25746 116590 307821 50689 58982 85492 116696 83613 312754 300980 66023 25525 25326 314612 305203 312664 25136 432361 287716 114858 58960 192126 29542 192213 25467 192117 364052 246150 315648 305614 299147 288589 25400 25150 59323 25344 171140 84598 170577 59325 25433 25676 310533 64156 50522 25581 81646 89807 89804 83805 681260 64159 498837 100912032 362045 56011 79114 81504 170633 83806 170700 313845 314384 54250 287670 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 25114 25022 29368 116499 100363500 60662 85385 170582 24525 66017 60464 29669 29677 29672 287772 287984 311078 RA BIOSYNTHESIS PATHWAY%REACTOME%R-RNO-5365859.1 RA biosynthesis pathway 307092 171516 362757 24172 25061 353252 361504 308190 310903 116676 313689 297805 685750 312495 299511 170635 191574 100365958 500629 291283 266686 154985 ELONGATION ARREST AND RECOVERY%REACTOME DATABASE ID RELEASE 60%9438088 Elongation arrest and recovery 303132 304832 266787 301119 289561 311796 25562 316123 305851 294258 287608 293184 103690054 306261 306347 364834 81785 361365 305455 303281 291705 362479 300837 498109 81674 100361574 500715 292778 308472 690966 366169 304758 363633 117017 362110 64525 81807 363064 83503 100912534 315291 498453 361531 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%R-RNO-187577.1 SCF(Skp2)-mediated degradation of p27 p21 291983 362485 114851 83571 25729 289924 289990 58854 307821 29425 64156 94201 499655 83806 294790 287670 29675 295052 50522 29671 29670 24968 25581 24967 29666 117263 117262 161475 362817 85492 58919 114494 83499 29614 29669 689852 303353 681260 287716 29668 292766 362356 29677 29672 365388 81827 498837 287772 100912032 287280 287984 366275 311078 94198 29630 296651 408248 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 60%9438661 Association of TriC CCT with target proteins during biosynthesis 299809 294864 29374 288620 297406 295230 24818 288305 CATABOLISM OF GLUCURONATE TO XYLULOSE-5-PHOSPHATE%REACTOME%R-RNO-5661270.1 Catabolism of glucuronate to xylulose-5-phosphate 171408 24788 290277 316067 78959 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME%R-RNO-428930.1 Thromboxane signalling through TP receptor 89788 81662 24816 24400 81666 309242 303634 TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME DATABASE ID RELEASE 60%9437805 TP53 Regulates Transcription of Cell Cycle Genes 362485 114851 83571 25729 305909 313017 298795 25737 360917 299805 312227 363221 301513 54237 25203 308311 306492 295707 363603 295052 83722 291841 261730 314818 308607 25112 29619 362817 58936 307511 114494 24887 SHC1 EVENTS IN EGFR SIGNALING%REACTOME%R-RNO-180336.1 SHC1 events in EGFR signaling 291983 171109 24514 246145 289924 246144 24628 24629 293847 313874 25453 289990 25597 314596 29434 364686 116562 58854 102552659 170668 29425 65179 64156 24408 25167 64030 24716 24410 24412 117281 24446 498576 29675 50522 29671 29670 29376 24968 25581 24967 29372 690919 25704 112400 29666 24337 24329 117263 117262 116663 364814 290206 24592 103694903 64022 161475 360814 24703 83499 24245 24244 89807 25267 309179 89804 29614 29496 295234 29211 689852 64363 24497 652957 116630 140924 114103 24246 83805 303353 289257 681260 84423 84422 29668 29495 25614 64159 292766 691318 25266 362572 360573 60427 24672 309168 365388 81827 24673 498837 100912032 288924 171081 24242 291245 94198 296072 29630 81511 296651 408248 304893 24586 25746 362045 116590 56011 307821 79114 81504 170633 50689 83806 170700 313845 287670 54250 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 25114 25022 29368 116499 60662 85385 170582 85492 24525 66017 60464 83613 312754 29669 300980 66023 25525 25326 314612 305203 312664 25136 432361 287716 114858 29677 58960 192126 29672 29542 192213 25467 192117 364052 287772 246150 315648 305614 299147 287984 288589 25400 25150 311078 59323 25344 171140 84598 170577 59325 25433 25676 310533 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 60%9438066 Innate Immune System 100364062 298682 498300 294673 289924 192264 308163 252902 306324 24590 24206 24591 29645 63880 299314 683849 305679 252915 100909700 361208 306332 574531 83578 100909977 306871 315949 100360977 29692 102557319 58826 50692 282817 171293 299331 306891 316033 306600 292072 498840 50645 316035 499271 302495 58970 688730 361537 689064 292073 292804 303542 24191 499985 302890 303413 170538 290029 140607 361635 293118 58857 289185 690130 308869 303414 308875 499157 316014 364867 140868 170667 313658 59313 305234 100360087 295234 316516 499285 116591 50866 63849 361516 316519 295347 303353 679787 100362805 306760 681706 313648 29543 365183 445415 304822 501742 362638 498276 291948 100910990 361378 29153 304966 287709 690158 361677 365388 361171 361467 24157 24159 84397 361370 29142 312647 365865 29511 29143 367915 24189 287721 24390 308632 94198 94197 361697 298066 310612 29714 287813 314618 314615 291000 310416 314856 117029 116590 291755 310553 50993 291339 50689 50557 362119 499065 688047 299809 292666 299606 246272 29385 309147 308995 301535 84007 363024 64537 292668 314843 29398 25290 29565 116690 361819 29364 291085 291091 116689 499099 499933 292537 29448 315085 315084 83462 299052 295647 117284 25052 64035 362249 287427 690230 299277 79113 25581 292413 103694877 25441 116547 292419 25308 25455 292409 24426 103690020 64189 64185 65029 25046 292306 79209 308350 292594 54243 24917 54249 25319 29292 64046 24944 79239 171361 113940 65197 84431 315272 54258 103694893 304485 116500 363494 690263 304988 171547 100361866 24926 367562 116967 113959 287435 170923 84586 295956 103690289 64159 65192 299159 83841 500361 100361543 114091 103690254 300857 171341 266775 689388 84497 171551 296356 299783 360914 293650 299276 289322 25531 25021 83730 288702 170496 304284 25406 56611 25151 286995 315348 362347 296321 315764 84491 25019 25407 288305 81641 309419 81637 408247 690945 362045 306998 29192 362859 299121 103694857 81503 307483 156767 66021 297081 25227 362029 690492 289318 432363 81683 25524 25035 25328 362329 81687 25423 25528 117152 83806 89812 24645 171337 83527 287670 498209 259275 290257 361422 311821 81506 24257 24256 25630 89824 83799 289231 81650 29184 498128 81649 289032 498234 192177 29738 309684 24251 362966 296654 296655 29186 24479 83781 252929 364705 312317 102554637 361598 310864 690906 60350 313087 29669 81679 363522 362432 25518 81675 289211 312316 25619 498022 24248 286958 114105 24232 363463 29757 294329 408224 289820 24691 288174 408229 290923 25505 81762 29677 100364984 689955 29672 297173 100125364 290409 311865 316333 298792 114023 287772 58949 282838 79129 287984 303666 25096 311078 79130 100909857 25095 63865 100362738 24434 29662 100134871 81736 362893 313837 25097 289632 24223 102557244 310131 296648 304859 25050 29432 64044 24674 117553 54244 502902 360640 64171 288375 288378 363856 360647 81678 311658 100361818 100360982 501797 100910732 361400 83477 54223 298508 305509 64156 690966 64508 84420 50522 81822 361509 83503 85420 89807 29741 89804 85243 83805 24680 681260 498109 100361574 78963 58918 498837 295378 116725 100912032 29431 29433 100912534 29748 56011 24224 302422 79114 81504 170633 25513 170700 313845 54250 25443 25444 170579 316213 293621 314850 25317 170583 29348 29349 84489 24605 361388 25114 25738 25022 29368 116499 25622 60662 85385 170582 24525 66017 60464 308901 295279 302950 259242 24508 690894 305842 24854 317676 310178 295703 24481 361696 24934 294048 64545 84482 65261 24954 50686 304987 293774 79240 100911527 24506 24505 294235 299567 84027 498888 308873 641627 294515 83687 365367 59265 50585 100912356 289395 303861 289057 493810 29333 29337 311559 500338 100912314 290749 298205 298211 298210 498284 298696 24236 24235 24233 24237 295180 24599 24598 312705 155012 365466 498241 24258 24231 502965 502966 502962 685161 299354 29687 113936 29684 29169 25621 103694852 297566 689779 117596 297797 291969 296981 24941 297932 116455 366545 289407 362802 500904 94170 685232 24884 684969 360426 360620 58823 313024 287876 65172 301009 313264 679934 29414 497963 79249 501738 499658 303073 298566 192262 81750 406161 309081 103689965 361251 362271 54227 117542 100361457 114553 296545 103690314 117538 288669 114851 54225 83571 25238 682507 314641 29699 24679 297989 24681 29241 361373 81732 300678 25300 363577 368044 29513 296603 60352 302415 300955 155918 317371 312937 29691 297518 287362 116664 29665 117514 436582 300732 290408 58923 315435 299971 100911854 64668 690076 246238 299827 298288 445269 100909750 25110 314336 301227 301229 299928 246244 64459 499069 296290 500491 24620 311860 292545 309014 360557 313421 311430 363984 294257 29251 84355 54303 25679 25262 64465 25521 25289 25725 64532 293508 56822 25636 25408 25660 291983 171109 305354 24514 305353 246145 246144 24628 24629 293847 317468 29260 313874 25453 684440 289990 680127 25597 364594 314596 292892 29434 685174 364686 310461 116562 58854 102552659 170668 361689 29425 65179 246116 24408 314764 25167 312562 64030 64023 24716 24410 24412 56718 117281 24446 498576 29675 366588 29671 362862 29670 29376 24968 24967 29372 690919 25704 112400 29666 24337 362858 24329 117263 117262 116663 310685 311487 364814 300088 290206 24592 361640 103694903 246273 64022 366277 161475 301246 360814 24703 64226 83499 24245 24244 338457 25267 309179 29614 29496 29211 689852 64363 24497 652957 116630 140924 114103 24246 24855 289257 84423 361992 84422 29668 81745 29495 25614 292766 691318 25266 363131 362572 360573 60427 24672 309168 81827 24673 292887 288924 171081 24242 291245 296072 29630 81511 296651 408248 304893 24586 25746 25374 29205 25373 100365047 301574 308666 360854 25739 288779 363127 84387 29214 301034 367455 293753 293154 307039 299732 94167 307821 84386 303180 317335 64350 24856 64529 246250 301005 64527 361619 308394 684322 613221 304688 498659 613225 301252 29221 296076 140656 296370 25741 293130 690198 691533 100361909 307833 304543 85274 295706 363247 140665 301261 100911825 474169 497195 84379 103693683 85492 116643 363875 246358 315306 304692 25233 83613 312754 24185 300980 66023 25525 25326 314612 305203 312664 25136 65052 432361 287716 315222 25103 302526 292485 114858 58960 192126 29542 192213 25467 192117 364052 246150 315648 305614 299147 288589 25400 25150 59323 25344 171140 116484 84598 170577 59325 25433 25676 310533 303024 366508 25493 689314 362896 363855 314322 81771 308267 363520 498003 296390 25272 24494 287398 25734 100912585 315305 305549 114509 81647 301059 305451 309361 289014 81646 309165 84351 24600 81722 287707 25742 305751 81525 54226 361831 84477 291912 29469 314384 313121 500133 679539 362418 305835 100363500 361765 84492 315139 311245 25155 114495 25156 100910771 317546 683206 50658 24932 361565 300447 100912399 116596 116667 303200 315994 100912618 361102 501560 54245 685465 116554 24516 690254 362356 306012 81515 300177 309452 117269 287280 309295 29175 362491 60587 309957 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME%R-RNO-72203.1 Processing of Capped Intron-Containing Pre-mRNA 289693 81781 287113 192246 361859 361522 103689936 680891 302879 298075 310687 100360750 300361 287530 689890 313035 287739 290647 361849 170933 292683 494445 117280 307410 687575 366952 681410 295270 297695 295334 681031 302557 688288 100359574 100911462 311670 298095 85434 684148 306222 360613 140931 679890 365407 100363406 296913 114765 362829 315903 362153 362264 362361 298385 687679 287765 287768 500684 79256 89819 298374 304859 289561 103690054 245976 298508 364834 361365 292778 690966 362394 246216 117017 83503 53372 294429 300259 299706 292085 117021 304862 58958 245922 113929 65274 498109 287830 363854 100361574 366163 116555 500695 362281 25281 683983 295692 291874 81738 499974 363633 113975 25497 362335 100912534 116697 303607 687711 80846 288701 362990 316123 302670 287170 314417 308650 296320 361574 294232 680737 29678 293505 362152 295607 319110 171365 311166 81674 313449 299620 689116 361814 293671 64200 290614 685273 361995 29667 291877 307524 84486 60376 308335 366461 690303 117259 361887 366276 291794 292019 309338 294711 362223 498934 286973 295284 296126 100361269 100360682 291295 297455 361808 300996 362612 501926 361605 363082 313620 360803 361542 291060 362687 498425 290666 691538 292536 84401 309651 315170 290519 361990 303057 89827 360845 362819 679894 305714 313308 360972 302729 305479 102548514 683927 299256 245957 114612 500378 300092 79227 317385 298916 291797 304277 295428 300208 499020 297336 361035 292007 117855 680309 292729 313583 500697 308653 689955 296219 59087 362098 501621 INSULIN RECEPTOR RECYCLING%REACTOME%R-RNO-77387.1 Insulin receptor recycling 170667 297566 689779 368044 117596 297797 291969 296981 29757 24954 299159 24506 297932 24505 116455 366545 289407 362802 293650 116664 94170 685232 436582 83615 299971 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME DATABASE ID RELEASE 60%9439040 Phosphate bond hydrolysis by NUDT proteins 290365 361274 305149 361068 287406 363129 117260 THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME%R-RNO-2187335.1 The retinoid cycle in cones (daylight vision) 24711 293049 313689 81644 89810 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%R-RNO-198693.1 AKT phosphorylates targets in the nucleus 361696 84482 100363500 294515 24185 81646 302415 79240