RNA POLYMERASE I TRANSCRIPTION%REACTOME%REACT_1309.2 RNA Polymerase I Transcription 3066 728340 8335 8334 1022 653604 3065 8337 8331 902 30834 255626 8358 333932 8352 8359 9013 8353 8354 9014 8338 8339 677805 9533 474382 4331 8357 8356 8347 57459 8348 8345 7270 8346 6908 8340 57504 79101 10849 54700 8343 8344 8341 8342 3021 64425 3020 692063 85236 2968 2967 8968 8360 8362 8361 100302240 84172 8364 54145 8363 8365 8366 8970 8368 8349 8367 100616282 5928 8351 654320 9112 8350 9015 25885 8355 5595 3013 3012 51082 284119 692072 54815 5440 677822 8932 723790 5441 126961 8294 11335 7343 677792 2068 2074 2071 5931 8850 554313 121504 9219 3015 3014 8370 3018 2965 2966 3017 53615 1108 1107 2648 10919 5437 5434 5435 128312 221830 REGULATION OF PAK-2P34 ACTIVITY BY PS-GAP RHG10%REACTOME%REACT_13528.2 Regulation of PAK-2p34 activity by PS-GAP RHG10 79658 5062 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_115529.1 Interleukin-7 signaling 5296 3561 3575 3574 3082 6777 3716 6776 3718 8503 5295 BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME%REACT_111046.1 betaKlotho-mediated ligand binding 152831 2264 9965 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_18423.5 ATF6-alpha activates chaperone genes 811 7184 4801 22926 1649 3309 4802 100500842 4800 468 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_13819.1 Regulation of gene expression in beta cells 10000 4821 6927 3171 3174 4825 207 208 6514 3375 389692 5080 2308 3651 2645 3630 4760 3170 RECYCLING OF EIF2:GDP%REACTOME%REACT_1815.2 Recycling of eIF2:GDP 1967 1968 8890 8891 8892 8894 1965 8893 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_120756.2 Synthesis of PIPs at the early endosome membrane 3631 285540 9110 5289 8898 5286 8821 30849 55697 55300 4534 200576 9896 55361 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX%REACTOME%REACT_2141.4 Assembly of the RAD51-ssDNA nucleoprotein complex 5893 6119 6118 6117 5888 SCAVENGING BY CLASS B RECEPTORS%REACTOME%REACT_163679.2 Scavenging by Class B Receptors 948 335 338 6288 PEROXISOMAL LIPID METABOLISM%REACTOME%REACT_16957.2 Peroxisomal lipid metabolism 3295 215 1384 26061 8540 10005 23417 10478 11001 8310 8309 30 23600 54677 84188 5264 8443 55711 3417 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_121123.3 Reversible hydration of carbon dioxide 760 766 771 765 11238 763 100507258 377677 759 768 23632 762 761 GABA RECEPTOR ACTIVATION%REACTOME%REACT_25199.1 GABA receptor activation 112 115 114 94235 3773 111 113 346562 23229 196883 2570 2785 2786 2783 3760 3761 2784 2787 2788 2560 2561 2562 2569 2567 2566 100996843 200959 2557 2554 2556 3759 55970 2559 107 2558 108 54331 2793 109 2771 2792 2790 2770 3768 3766 100134444 3763 3765 2782 3772 9568 3762 2774 2550 2555 55879 2773 PLATELET HOMEOSTASIS%REACTOME%REACT_23876.2 Platelet homeostasis 5781 10242 338 59345 487 94235 5136 5777 10335 4846 6546 5321 3710 5175 5739 5023 489 488 3779 3778 7804 50940 2982 2785 5593 2786 51764 2783 2983 6547 4842 2784 4843 2787 6786 2788 2791 2977 2268 8654 3708 3709 5140 1432 5138 5519 5139 5518 55970 6543 5515 5516 57113 84876 2778 54331 10681 2793 27345 27094 5153 2792 5152 2790 10846 5529 5528 5527 490 491 5525 492 2782 493 5526 7225 7222 CELL JUNCTION ORGANIZATION%REACTOME%REACT_20676.1 Cell junction organization 1012 137075 10686 1013 1308 1016 3655 7016 5817 5819 55679 56288 5339 9080 1015 23562 5818 999 10207 1003 1001 1002 1004 50855 1005 9459 1007 1008 9071 9073 1006 55742 9074 3728 1009 9075 57863 64398 9076 7122 50848 1010 87 5584 23705 9069 977 149461 100288695 49861 92359 29780 3691 7408 3611 24146 6251 3918 3688 3914 64403 53842 54751 1495 1000 51208 25945 2318 10979 2316 84552 26285 84612 3909 5010 667 1500 253559 1366 3987 1365 1364 5829 81607 NCAM1 INTERACTIONS%REACTOME%REACT_18312.1 NCAM1 interactions 776 1282 100132336 6900 1298 1285 375790 1284 9048 4902 8128 1297 7903 1287 2674 2675 2668 8911 8912 8913 131873 1299 1463 1286 775 5623 5621 256076 779 1292 1291 784 4684 785 782 64096 783 1293 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_115810.1 Sphingolipid de novo biosynthesis 2657 29956 259230 55331 10715 79603 8879 8877 5587 9218 123099 340485 8613 91012 253782 56848 10558 2531 9217 9517 8612 204219 151742 8611 81537 125981 55304 8560 130367 1455 166929 5007 HYDROLYSIS OF LPE%REACTOME%REACT_120785.2 Hydrolysis of LPE 56261 8605 S33 MUTANTS OF BETA-CATENIN AREN'T PHOSPHORYLATED%REACTOME%REACT_228159.1 S33 mutants of beta-catenin aren't phosphorylated 5711 5710 5714 5713 1452 5719 3065 8945 2932 7089 23198 139285 7088 6500 5715 5716 1499 5701 7311 5696 5687 5695 5700 166 5694 6932 6934 5717 5718 5688 5689 8454 8312 5720 7316 10213 324 5698 83439 9978 5699 7090 7091 10023 143471 5721 6233 5519 5518 5515 5516 5529 1487 5528 1488 5527 23401 10197 5707 5525 5706 5709 5708 5690 5705 5691 5704 5526 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 51176 5684 5683 GENE EXPRESSION%REACTOME%REACT_71.6 Gene Expression 57677 54512 163051 163050 57176 730291 5438 5439 4141 5436 10250 23049 349075 100505503 55634 54778 167227 728957 22894 10262 116936 116938 286075 92285 11100 92283 65988 11105 4736 23054 7673 7638 7101 6301 84124 1917 84546 730087 169841 10421 163059 440077 285971 5451 8683 284309 10001 23478 25973 23471 100129842 284307 91975 101928852 7407 284306 90701 8669 5442 64216 163049 100131827 100126351 8668 23016 7181 25904 1994 4782 677847 4784 348327 163227 23293 81857 7625 7627 57615 7626 23019 10224 16 4774 51592 81856 169270 3842 7633 170960 7175 1981 55657 11340 126231 163255 1490 5600 342132 136051 10236 80317 51520 134353 147657 100302242 79230 80312 115196 23020 9612 23225 9611 353088 10498 353274 7618 7652 55888 162239 83443 163223 4781 55663 7182 51585 51586 10499 7621 79175 6137 9939 6136 6138 6139 219578 6907 9668 155054 101060386 6130 6133 6132 6135 6134 6143 6144 6141 6142 6147 606500 79943 6146 101928686 3178 155061 3172 199777 9669 9261 661 389114 1978 4116 147694 1974 1973 1977 1975 7884 55659 11338 1983 126382 56339 728927 54790 6129 6128 170959 1477 3164 6917 54989 6910 1478 23279 10482 79902 285902 147686 147687 1479 6124 6726 6123 6122 6729 6728 6125 6727 574040 219988 9282 9410 3192 3191 55814 90589 6176 6175 90592 162967 100500804 10189 162963 8175 8178 100287226 892 9416 9968 101060521 11051 9969 339500 3303 158078 90576 3187 9295 55802 3188 3184 3183 3185 9688 6741 3181 2058 29883 56259 3190 6921 9972 6924 6923 6731 9975 6730 29894 6734 3304 101928434 6940 2063 2617 5711 5710 5714 5713 5719 23198 5715 5716 5701 7311 5696 5687 5695 5700 5694 5717 5718 5688 5689 5720 7316 10213 5698 5699 143471 5721 6233 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 5684 5683 5465 1030 5464 85390 163071 27257 1025 1024 22826 84765 5093 51742 27258 22823 163081 94039 85388 5467 284370 5469 1964 5094 85389 5468 904 124411 905 5859 652965 23480 1915 652966 8648 57693 100126332 7421 57690 104 103 10413 285268 285267 8663 57819 8661 8662 22869 10419 8666 8667 8665 5054 64426 8664 5431 10025 5433 5430 84527 5432 124454 1936 51503 90075 340252 22835 253639 1933 1937 84775 25920 1938 51728 100508408 25929 65110 25937 55699 197320 163087 55290 5073 57122 121536 58500 285676 51333 5494 25942 168374 117608 65109 3066 6231 6232 728340 1875 8335 1874 8334 1022 2521 4904 653604 3065 9521 148156 8337 9125 6044 11176 9128 115509 8331 902 9534 790969 30834 6043 255626 3720 7753 6621 7752 55749 158399 55746 100527943 6228 6229 80110 6227 6235 6230 6234 80108 53981 8358 333932 126070 55718 8352 221785 8359 9013 654254 9794 8353 55713 8354 9014 23619 23405 8338 23404 8339 677805 199692 9533 2197 474382 11198 4331 2193 125919 8357 6827 8356 23411 8347 57459 3646 9785 8348 9789 8345 55703 7270 29079 8346 6908 80139 1656 8340 1650 57504 2516 79101 24148 10849 54700 1660 6256 8343 6258 8344 6257 8341 6839 8342 6606 3021 64425 4609 6604 3020 22794 692063 126375 85236 9887 2968 51690 2967 51692 8968 6224 8360 6223 8362 440519 8361 100302240 6222 4221 84172 7733 8364 6607 54145 7738 8363 7050 8365 6203 8366 6201 8970 6202 8368 54487 8349 55534 8367 7711 100616282 10594 5928 7728 8351 654320 9883 4092 9112 23395 8350 9015 3735 23112 25885 80205 8355 113835 5595 6619 3013 6210 3012 51082 3726 284119 101929496 84671 692072 7068 54815 5440 56242 677822 353355 6205 8932 9862 723790 5441 6204 90390 126961 6208 8294 11335 6209 6206 7343 677792 6207 2068 6217 2074 102157402 2071 7743 65243 5931 440515 8850 554313 80222 121504 100130863 9219 6218 7745 3015 3921 3014 8370 56915 7067 3018 6617 2965 65251 2966 7748 3017 53615 6618 7767 7768 4677 7766 7770 7965 7769 100131980 11218 55778 7760 92935 171392 4670 7762 10352 51639 1108 7757 1107 30832 2648 7538 10919 5437 5725 5434 7761 5435 57794 7755 128312 285349 100129543 55181 374900 221830 200424 7539 51003 552900 4853 4854 4855 55786 11224 441234 23381 7712 7978 84441 56006 255403 7988 23378 84436 4851 4088 4089 4848 23165 84449 144348 390927 4849 7771 5520 4878 7773 729944 55762 4850 4087 27316 51616 51808 25804 10949 10946 90827 26149 283876 26147 619505 342926 400720 84924 8565 7529 57541 57547 84626 6667 199704 27300 55176 7534 140612 129401 196513 10127 84914 26795 7700 7702 1387 27335 10921 27339 57573 57038 6418 220988 51010 7549 5178 26974 10907 4686 51013 26152 7936 27327 10914 147741 7551 619279 7552 5933 26986 84911 7556 220992 374928 10520 100289635 7514 26787 6428 6429 55571 5393 340385 101928160 6430 6625 57711 26784 26781 6629 57505 26780 6628 6627 6432 6626 6431 84265 26778 57510 367 90874 51067 6634 121274 6633 26771 6635 6636 64750 7004 6637 7005 201514 5976 7003 7029 171568 51058 25873 7307 26523 7710 54464 256051 57335 7019 10302 5580 22938 84246 10308 57336 7027 8570 94163 8575 26791 7025 26790 5578 26048 101060318 162972 84967 833 96764 79759 79755 101928623 5916 101929245 5915 28972 255967 7453 5914 388567 388569 388566 27297 5917 79744 10605 101929240 23521 58477 6745 5241 595100 339327 442319 51385 55110 8106 148254 388561 6748 6749 6746 6747 148266 148268 58492 10623 10621 10622 5252 58491 59348 27068 8125 146434 388536 11097 79718 51362 6632 6427 6426 219749 23511 57343 23512 57209 6165 6168 9924 2099 6161 6164 90338 6160 10155 79788 23309 158431 9045 60436 6167 6169 28960 10644 10643 619569 619567 619568 5903 3376 7678 79587 619565 142 619562 93134 7458 10642 8819 9477 148213 80818 100529097 118460 7469 101060589 29115 147837 5901 6996 101929740 339559 79731 80095 51121 6193 10667 6194 100131539 25888 6192 6191 26019 148206 246175 29102 148203 51123 860 55157 79970 23327 79973 54938 9631 387032 693221 4809 6171 6170 6173 10181 112950 162966 9422 90594 100526842 10172 90317 646915 1786 80264 3312 6189 6188 1788 3315 6185 3516 92595 1789 6187 79986 10168 7692 7695 80032 9439 7694 7697 90333 7699 79595 283459 100996747 79760 6181 6184 677 9443 9441 9442 23708 83860 6154 6155 6152 9255 6159 9440 6157 6158 54925 6156 1432 5518 5515 6872 10992 6874 8741 90233 25799 26809 282890 339 6873 138474 100124516 23658 100302196 6877 374655 100302197 8726 6881 6878 6875 23644 8731 6880 6097 79818 6883 63934 6884 146542 6096 8732 6882 6497 146540 8021 6095 2957 6498 2959 2958 147948 147949 79088 79084 8431 7323 22916 2960 2961 2962 2963 84874 10073 85456 7321 6897 401509 2100 90649 79833 91120 8427 85441 374879 2972 8239 2976 2971 2975 168417 5356 6895 51497 6083 8243 23636 8463 2103 2104 2101 29959 2107 10056 7586 8894 7587 1965 7582 8893 7581 9310 10762 84838 101929876 7571 55900 988 1967 127396 27161 1968 146198 8890 7594 8891 7596 8892 10952 7592 100507342 162655 619499 8467 101927758 100302143 51276 8480 57474 284443 84844 7562 9328 9329 26819 26815 7566 57472 7561 26817 26818 7567 26816 7576 7574 50628 79869 344787 79862 101928747 10046 147923 8487 10978 26820 7376 7568 147929 348995 54807 9343 10795 283337 2146 10794 10793 9349 53371 11157 54811 152687 10291 79685 4927 4929 284459 27153 7559 9330 26811 7565 8086 26814 10780 9337 192669 10781 29927 10782 23660 1207 595097 595099 10284 192670 3174 114026 83744 60559 207 29974 6829 126068 23438 80778 10286 11128 80153 595098 148103 9150 1615 79898 55422 23450 23451 79891 79027 9775 3035 8944 93474 9572 79023 100616459 VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME%REACT_24023.2 Vasopressin regulates renal water homeostasis via Aquaporins 2785 2786 51764 2783 2784 2787 2788 2791 55970 107 108 2778 54331 10681 2793 109 2792 2790 112 115 59345 114 2782 94235 8766 360 111 5577 361 113 196883 5576 5573 5568 5567 5566 22841 551 554 4645 358 5575 359 PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME%REACT_20515.1 Proton-coupled monocarboxylate transport 9194 9123 23539 6566 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME%REACT_20649.1 Cell-extracellular matrix interactions 7408 3611 6251 9459 3688 7016 54751 55679 55742 2318 10979 2316 87 3987 100288695 5829 29780 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_15497.2 PKA-mediated phosphorylation of CREB 801 805 808 1385 112 115 114 5577 111 113 196883 5576 5573 5568 5567 5566 107 108 109 5575 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_111184.1 Negative regulation of FGFR signaling 152831 2264 9965 7311 5518 5515 5516 26281 10818 5595 10253 2247 2246 2249 2255 5781 8823 673 27006 2251 2252 867 2254 2248 7314 8817 8569 8074 7316 5594 6233 CLASS II GLUTS%REACTOME%REACT_19281.1 Class II GLUTs 56606 6518 66035 155184 PRE-MRNA SPLICING%REACTOME%REACT_467.3 pre-mRNA splicing 26787 6428 6429 2521 4904 5438 6430 5439 6625 5436 10250 9128 6629 6628 6627 6432 6626 6431 10262 55749 11100 6634 6633 6635 6636 53981 10992 6637 10421 7307 8683 9785 24148 1660 100126351 100302196 51692 10594 101929240 55110 8106 22916 10236 2962 2963 5440 5441 23020 51362 83443 6632 6427 6426 5356 51585 8243 9939 85390 22826 5093 4670 51639 988 5725 5437 5094 5434 57794 85389 5435 3178 4116 84844 100529097 11338 1477 79869 101928747 1478 10978 1479 27316 9343 10949 10946 693221 4809 10181 9410 10291 3192 3191 57819 10189 3312 8175 5431 9416 5433 5430 11051 5432 10921 51503 27339 3187 9295 220988 3188 3184 3183 3185 283459 10907 10286 4686 3181 56259 3190 10914 23450 23451 29894 100616459 65109 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_163919.2 Inactivation, recovery and regulation of the phototransduction cascade 801 805 808 6295 2779 10988 9397 2979 2978 5588 5158 2339 23173 2342 388531 2792 9626 5145 100529261 5957 2986 2782 6010 6011 1258 5148 1259 3000 4836 5475 5578 INSULIN PROCESSING%REACTOME%REACT_15550.5 Insulin processing 3630 55676 149371 10640 148867 30001 23265 169026 1363 4644 56605 5122 11336 54536 55763 5126 3800 5873 3799 55770 60412 1369 6844 3798 6804 64924 RHO GTPASE CYCLE%REACTOME%REACT_11051.1 Rho GTPase cycle 64411 391 393 392 395 394 116985 10928 55114 10276 51306 79658 171177 64333 23092 116984 58480 51291 80728 1124 79822 1123 9886 9901 553158 7410 89846 9743 23263 29984 7074 7204 10144 57569 90627 89941 1894 9912 29 8874 7409 644086 29127 84144 101928361 101928667 23229 25791 55843 9754 9459 8997 23779 54509 9938 26230 11214 89839 2 57449 10451 64857 2245 158763 57381 221472 388 387 27237 389 5881 23365 6453 23221 5880 257106 3633 4650 2909 58504 2665 2664 115703 85360 57522 5924 5296 117289 9322 84986 4983 57514 4168 6654 4649 23433 100288637 396 613 343578 94134 23526 9181 399 998 4952 93663 397 398 121512 83478 9828 57636 55288 101930241 91614 23380 50649 6655 84033 9826 23370 50650 9824 9411 10395 55789 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME%REACT_2051.2 Formation of Fibrin Clot (Clotting Cascade) 2812 2811 7450 2147 5547 2243 3818 5624 2162 2161 2 462 7056 2165 2160 710 2815 2814 3827 2266 708 2153 2244 2152 7035 2158 2155 2159 5627 5197 2157 5196 DAP12 INTERACTIONS%REACTOME%REACT_147694.2 DAP12 interactions 6199 9402 3815 3813 57292 23601 400709 2932 7305 5581 23035 5582 572 5604 3810 5605 2064 3805 1950 3808 1026 3804 6850 3806 3803 100049587 7410 3265 5879 145957 2931 1027 8503 1956 3809 2309 5156 3937 8660 22914 112 5335 115 54209 114 7409 5336 100132285 10326 5137 111 2069 113 26523 695 3133 196883 5155 814 3824 3822 7249 5580 342510 983 2475 3107 3106 1839 3932 284266 23239 842 1147 50852 5894 5578 801 253260 156 805 7297 808 100528032 1385 100133046 940 3084 685 942 941 3708 3709 100996743 3845 84335 9436 64223 4893 26281 101060747 3717 10818 4193 9542 930 5170 5159 57761 23112 5153 10718 5595 54210 2247 2246 2249 2255 8823 27006 2251 2252 2254 2248 8817 8074 5594 2549 100653194 5291 5293 27161 567 3569 3667 2534 5728 3570 117145 553128 79109 5290 4343 124599 5781 10451 5577 5136 5576 5573 5568 5567 3164 5566 3710 5575 152831 2264 9965 57690 7529 107 5296 108 192669 109 3716 6654 5295 10000 192670 207 208 2308 27327 NGF PROCESSING%REACTOME%REACT_11062.3 NGF processing 5125 5046 5045 100507472 4803 RECYCLING OF BILE ACIDS AND SALTS%REACTOME%REACT_11042.2 Recycling of bile acids and salts 8648 2172 6555 10599 570 213 345274 8647 28234 8714 9971 6554 6256 10998 10499 6579 MEIOSIS%REACTOME%REACT_111183.1 Meiosis 93426 1017 8335 7014 8334 7013 23345 653604 54386 7156 8337 1019 50511 8331 255626 56158 8468 641 4001 4361 5889 5885 29893 4683 23224 27030 3306 84057 9126 23353 6847 8358 333932 8352 8359 8353 8354 8338 8339 474382 8357 8356 8347 8348 8345 8346 8340 8343 8344 8341 8342 3021 3020 85236 8968 8360 8362 8361 8364 54145 8363 8365 8366 8970 8368 8349 8367 100616282 8351 8350 8355 3013 3012 723790 126961 8294 554313 121504 3015 3014 8370 3018 3017 8243 128312 6119 6118 6117 5888 25913 256126 56154 10388 56979 26277 4438 4439 10734 10111 23626 10735 7329 9985 10274 25777 545 11144 8290 5932 672 4292 27127 472 65057 675 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_169178.2 Defective CD320 causes methylmalonic aciduria 55191 4552 1719 4548 32 4594 31 23475 9446 5743 5646 8029 5645 55229 5644 25974 55312 81034 316 53354 55163 8034 6947 10560 55034 81693 9962 3141 9963 56922 60496 60490 27010 8566 166785 23057 5095 326625 5096 101929880 440387 101928493 6948 6470 1504 51293 349565 80025 64087 4338 27249 4524 54 6573 51248 113278 80347 101928717 2694 5091 4522 119391 113235 27304 65220 80704 79178 200895 6515 6513 93100 5167 55788 8884 80308 5740 1528 79717 4363 1582 2194 1727 10135 686 64802 10243 79646 NADE MODULATES DEATH SIGNALLING%REACTOME%REACT_13526.3 NADE modulates death signalling 835 27018 4804 7531 836 4803 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME%REACT_21264.1 Formyl peptide receptors bind formyl peptides and many other ligands 351 6288 2358 2359 301 2357 50865 ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_1194.4 Activation of NOXA and translocation to mitochondria 7157 1869 5366 7027 NICOTINATE METABOLISM%REACTOME%REACT_11088.1 Nicotinate metabolism 55191 23057 93100 101929880 23475 5740 5743 64802 65220 1582 349565 10135 EPHB-MEDIATED FORWARD SIGNALING%REACTOME%REACT_228085.1 EPHB-mediated forward signaling 1072 2051 3984 3985 60 2047 387 9475 2049 6093 2048 1947 6453 2902 2904 5747 8976 1949 1948 7525 5058 5921 10093 10092 10552 2534 10097 6383 10096 3265 5879 10094 71 10109 4067 7074 64283 8997 998 2050 LATE PHASE OF HIV LIFE CYCLE%REACTOME%REACT_6361.7 Late Phase of HIV Life Cycle 728340 1022 5438 5439 5436 902 7311 9397 55746 6872 6874 6873 11198 4331 138474 4836 6827 7316 100526767 1104 6908 155382 25978 55048 101060363 91782 29082 51160 6233 27183 5478 6877 51534 51652 7251 51510 6881 10015 2968 6878 2967 79643 6875 128866 5902 27243 8731 6880 92421 79720 137492 6883 9525 5905 6884 8732 6882 8021 2957 7175 9883 2959 2958 22916 2960 2961 6749 2962 5440 2963 100302242 5441 7314 23225 2068 102157402 2071 11097 23511 51497 2965 2966 23636 1025 10762 5045 5437 5434 5903 5435 904 905 8480 7469 5901 23165 6917 23279 79902 348995 51616 23327 9631 100126332 53371 4927 8086 8178 129401 5431 5433 5430 5432 6829 25920 9688 4686 7936 9150 6921 9972 6924 83860 6923 57122 79023 7514 CLEARANCE OF DOPAMINE%REACTOME%REACT_15514.1 Clearance of dopamine 1312 6531 4128 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME%REACT_952.1 Synthesis of glycosylphosphatidylinositol (GPI) 55650 9487 8818 5281 23556 93183 284098 54872 5279 5283 5277 54965 9488 51227 84720 GABA A RECEPTOR ACTIVATION%REACTOME%REACT_24987.1 GABA A receptor activation 2560 2561 2562 2567 23229 2566 2555 55879 2557 2554 2556 2559 2558 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_121237.2 Latent infection of Homo sapiens with Mycobacterium tuberculosis 4842 4843 527 528 1535 526 525 1536 523 9114 653361 529 9296 51382 50617 23545 4057 4689 10312 4688 245973 8992 245972 127124 101927180 533 534 535 90423 51606 820 155066 6556 9550 4846 PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME%REACT_308.5 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes 1017 9134 898 5925 S PHASE%REACTOME%REACT_899.6 S Phase 5711 1017 5710 5714 5713 1022 5719 1019 23198 6500 902 5715 5716 5701 7311 5696 5687 1026 23047 5695 3978 5700 5885 1163 5694 5717 5718 5688 9126 5689 1027 8454 51343 5111 51659 8900 5982 6502 5981 5983 2237 5001 4999 5000 7465 4998 4331 23244 9837 5720 4171 7316 5426 10213 5425 4176 5424 5698 890 4174 4175 5699 5985 5984 1763 4149 23595 143471 990 5721 993 6233 994 4609 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 8243 5684 5683 9134 898 5925 6119 6118 6117 5422 157570 595 84515 4173 23594 4172 5427 114799 23649 84296 23063 5557 113130 57804 5558 8318 10714 81620 10735 10274 GLUCURONIDATION%REACTOME%REACT_6784.4 Glucuronidation 54576 54490 54600 54579 7358 54577 54578 574537 101929773 7365 7360 10720 23169 7367 54657 7363 7364 54659 7366 10941 54658 INHIBITION OF INTERFERON SYNTHESIS%REACTOME%REACT_6301.4 Inhibition of Interferon Synthesis TRUNCATED APC MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME%REACT_228216.1 truncated APC mutants destabilize the destruction complex 5711 5710 5714 5713 1452 5719 3065 8945 2932 7089 23198 139285 7088 6500 5715 5716 1499 5701 7311 5696 5687 5695 5700 166 5694 6932 6934 5717 5718 5688 5689 8454 8312 5720 7316 10213 324 5698 83439 9978 5699 7090 7091 10023 143471 5721 6233 5519 5518 5515 5516 5529 1487 5528 1488 5527 23401 10197 5707 5525 5706 5709 5708 5690 5705 5691 5704 5526 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 51176 5684 5683 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME%REACT_938.4 Ubiquitin-dependent degradation of Cyclin D 5711 5710 5714 5713 5719 1019 23198 5715 5716 5701 7311 5696 5687 5695 5700 5694 5717 5718 5688 5689 5720 7316 10213 5698 5699 143471 5721 6233 595 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 5684 5683 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME%REACT_19230.2 Role of Abl in Robo-Slit signaling 6091 9353 10486 2817 25 10487 23122 23332 27 DISEASE%REACTOME%REACT_116125.6 Disease 8874 7409 27248 6527 1211 2243 6844 6804 23563 6199 8604 3815 857 8607 2239 8805 221823 3373 79586 5581 23035 2646 26020 5582 9469 572 5604 1523 9249 5605 83875 2064 3339 9040 1950 9653 3340 1026 92579 9445 4191 883 2652 1794 11285 3265 5879 4190 145957 8395 10165 2931 1027 10170 1956 3549 399687 2309 10678 9435 5156 9900 8660 9227 378884 10675 5335 79971 3320 100500810 3795 79577 5137 2632 2069 283464 8372 100616124 5155 2280 814 112755 11052 6120 7249 6121 54959 983 9958 2475 9957 11041 9956 1839 9955 3932 2060 23239 633 2806 842 2805 1147 11046 50852 5894 79369 253260 27087 156 5255 7297 5256 101929777 347734 940 5257 3084 11081 685 5214 942 229 941 226 411 343637 222236 821 176 178 6382 3845 643853 84335 5236 648740 64223 6385 4893 611 101060747 51384 3717 182 4193 26035 9542 3105 930 8841 5170 8644 5159 10855 57761 6597 10718 2821 388585 10861 2262 2261 50964 5929 3101 2263 9208 7471 26018 7476 60495 8630 2260 101929036 157506 7473 5213 7474 5210 7477 7478 7479 7472 5208 7276 5207 8608 7475 5211 8815 5209 6548 5034 23072 84133 277 278 56548 276 2547 2542 11116 266722 23462 284654 10402 280 51109 22856 7415 8650 58513 83464 10014 51107 5837 5834 64220 279 57154 1272 10817 5836 292 291 57680 8658 6576 100996919 6517 5260 10013 102 81029 293 2799 57818 5053 23493 5664 142678 8692 30011 6523 90780 6526 6524 26229 5261 230 54567 5499 1234 55690 51339 51564 55851 5634 7167 166012 11261 387 55824 3161 113189 3159 2027 2026 9951 9953 2033 9672 2597 151056 55869 5610 5611 101927462 3843 5617 1454 4775 1459 1457 2331 28514 24 6654 81847 83933 2584 2582 64840 613 9187 4773 4772 1471 3836 1464 998 2592 5631 1460 1462 1468 3837 7855 79412 10254 10252 5406 4166 79411 4738 54361 101929368 23220 23370 80326 5609 7852 80319 53630 3714 10331 3099 3098 6616 54894 5438 7750 5439 54492 3945 5436 7045 7048 56288 7046 3949 100505503 7040 3091 54778 51699 126792 56937 3073 123169 116936 101060233 116938 3074 113878 11171 127833 2535 2538 9844 4736 11168 2539 6857 2926 1857 1856 3038 9394 84546 8972 3055 3037 3036 2720 2934 9846 6843 11181 1855 2719 727936 796 80351 4958 9559 1645 145226 9759 29967 11197 101927965 6259 9101 3425 1634 3423 83737 6017 79885 4040 50855 9348 56998 4036 9148 9146 728458 9736 11140 4035 4023 10273 283149 8295 63827 8908 8907 51592 8905 50848 83999 8085 50846 8509 8702 7175 8704 8703 9331 4041 29924 1208 9334 4969 2997 2998 10057 29940 2990 64579 8065 100302242 8452 10053 2132 2131 5106 9612 5105 23225 960 9611 55454 1840 6888 6476 10082 325 1445 6482 6483 6487 6484 84870 85455 55276 1836 5829 2992 10956 2023 6137 135152 8313 6136 160 6138 55366 6139 59352 164 6907 163 162 408 409 6130 161 6133 340419 6132 7480 6135 7481 6134 51363 6143 5223 6144 7482 6141 5224 6142 7483 6147 5226 606500 7484 607 6146 2203 8323 8325 8321 8322 51377 59349 6772 10898 50999 10894 5230 6774 200010 6622 55576 26508 1174 1173 7015 8402 26108 101928143 1175 57016 6129 8788 6128 375 6448 8789 3164 337876 6917 6456 22943 5590 57530 23279 50700 26127 79902 90161 26330 6464 57534 22934 6124 25805 6400 6123 64711 6122 440193 5956 5959 6125 375790 8549 7520 574040 27123 5549 22987 130340 7518 10524 27121 6406 6176 51009 6175 6416 6422 5534 5948 5947 147111 5949 8178 4069 1463 5950 892 4669 101930388 1109 6423 51000 8534 9734 3303 4869 50515 7957 5530 5532 4060 3981 5507 9060 5500 9688 5501 4647 55790 7086 92737 2683 9070 6921 259307 9972 92126 6924 55501 1455 6923 89780 9061 84447 55737 9899 55733 3304 54480 57758 3938 23385 4240 5711 5710 5714 5713 1452 5719 8945 2932 7089 23198 139285 7088 6500 5715 5716 1499 6295 5701 2779 7311 5696 10988 5687 9397 5695 2979 2978 5700 5588 166 5694 5158 2339 6932 6934 23173 2342 5717 5718 388531 5688 5689 9626 8454 5145 100529261 8312 5957 2986 6010 6011 1258 5148 1259 3000 4836 5475 5720 7316 10213 324 5698 83439 9978 5699 7090 7091 10023 143471 5721 6233 801 805 808 1385 26281 10818 10253 1487 1488 2247 23401 2246 10197 2249 5707 2255 5706 8823 673 5709 27006 5708 5690 2251 5705 2252 5691 867 5704 2254 7314 2248 5692 8817 5693 8569 8074 5702 122706 5686 5685 5682 5594 9861 6518 9491 51176 5684 5683 25796 1030 336 337 6868 121214 1025 3280 1024 331 85388 8038 926 25776 221914 920 8724 6469 222537 93010 345 10090 348 904 8027 23645 905 3292 344 5577 5576 5573 5568 5567 5566 5575 100126332 57690 5054 5431 5433 5430 5432 25920 100508408 25937 57122 5494 3066 6231 6232 728340 8335 1875 8334 1874 1022 653604 3065 8337 6044 5062 8331 902 255626 3978 55746 100527943 6228 6229 6227 6777 6235 6230 6234 8503 8358 333932 8352 8359 9794 8353 8354 2237 8338 8339 2197 474382 11198 4331 8357 8356 6827 8347 8348 8345 8346 6908 8340 8343 8344 8341 8342 3021 4609 3020 85236 2968 2967 8968 6224 8360 6223 8362 8361 6222 4221 8364 54145 8363 7050 8365 6203 8366 8970 6201 6202 8368 8349 55534 8367 100616282 8351 9883 4092 8350 23112 8355 5595 3013 6210 3012 3726 5440 2817 6205 723790 5441 6204 126961 6208 8294 6209 6206 6207 2068 6217 102157402 7360 2071 8850 554313 121504 6218 3015 3921 3014 8370 3018 2965 2966 3017 527 528 1535 526 2648 525 1536 5437 523 5434 9114 5435 653361 128312 529 9296 51382 50617 23545 4057 4689 10312 4688 245973 8992 245972 127124 101927180 11224 533 534 535 90423 84441 51606 820 155066 6556 9550 4851 4088 4089 23165 4878 4087 51616 619505 7529 6667 7534 129401 26795 1387 4686 7936 27327 5933 7514 26784 26780 26778 26771 64750 7029 25873 26523 5580 22938 7027 94163 26791 26790 5578 23521 595100 8106 6749 11097 79718 23511 6165 6168 6161 6164 6160 9045 60436 6167 6169 5903 619565 142 619562 100529097 7469 5901 51121 6193 6194 6192 6191 23327 9631 6171 6170 6173 100526842 6189 6188 3516 6187 100996747 6181 83860 6154 6155 6152 6159 6157 6158 6156 4842 4843 3708 3709 5519 5518 5515 5516 5153 200895 5529 6515 5528 6513 5527 93100 5167 55788 5525 8884 80308 5740 1528 79717 4363 1582 5526 2194 1727 10135 686 64802 10243 79646 5045 2549 5291 5293 567 3569 3667 2534 5728 3570 117145 79109 5290 4343 5781 5136 4846 3710 7804 107 108 109 2792 2782 8290 6383 6872 6874 112 115 26809 114 111 113 6873 138474 196883 100124516 100526767 1104 155382 25978 55048 101060363 91782 29082 51160 27183 5478 51534 6877 51652 7251 51510 10015 6881 79643 6878 128866 6875 5902 27243 8731 6880 92421 79720 6883 137492 9525 5905 6884 8732 6882 6497 8021 2957 6498 2959 2958 7323 22916 2960 2961 2962 2963 7321 8239 3417 51497 6083 23636 55191 4552 1719 4548 32 4594 31 23475 9446 5743 5646 8029 5645 10762 55229 5644 101929876 25974 55312 81034 316 53354 27161 55163 8034 6947 10560 3630 55034 81693 9962 3141 619499 9963 56922 60496 60490 27010 8480 8566 166785 23057 5095 326625 335 5096 338 6288 26819 101929880 440387 26815 101928493 6948 6470 1504 26817 51293 26818 349565 80025 26816 64087 4338 27249 9110 4524 54 6573 51248 113278 10046 80347 101928717 2694 5091 26820 4522 119391 113235 348995 27304 152831 2264 9965 9349 53371 65220 80704 79178 4927 811 26811 351 8086 26814 5296 192669 3716 6776 5295 10000 595097 595099 192670 207 208 6514 6829 3375 2308 2645 595098 9150 8944 79023 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_25004.1 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits 2785 2786 2783 3760 3761 2784 2787 2788 100996843 3759 55970 54331 2793 2792 2790 3768 3766 100134444 3763 3765 2782 94235 3772 3773 9568 3762 2550 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%REACT_160305.1 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 9978 6500 8454 4851 FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME%REACT_1797.1 Formation of a pool of free 40S subunits 6231 6232 6044 26784 100505503 26780 7311 116936 26778 116938 6228 6229 6227 6235 4736 6230 26771 6234 84546 26809 25873 2197 100124516 3646 8669 94163 26791 26790 6233 8668 101060318 6224 6223 6222 6203 6201 6202 23521 595100 6210 6205 6204 6208 6209 6206 6207 6217 6218 3921 6083 6165 6137 6168 6136 6138 6161 6139 6164 6160 6130 6133 9045 6132 6135 6167 101929876 6134 6169 85388 6143 6144 6141 6142 1964 6147 606500 6146 619565 619499 619562 11224 100529097 26819 26815 26817 26818 26816 6129 51121 6128 6193 6194 6192 6191 26820 6124 6123 6122 6125 9349 6171 574040 6170 6173 619505 8663 100526842 8661 6176 8662 6175 26811 8666 8667 8665 26814 6189 6188 8664 26795 6187 595097 27335 595099 100996747 100508408 6181 595098 6154 6155 6152 6159 8944 6157 6158 6156 CELL DIVISION%REACTOME%REACT_1932.3 cell division 10735 23063 23244 10274 23047 5885 10112 23383 10726 25836 9126 8243 9493 5347 FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE%REACTOME%REACT_163810.2 Ficolins bind to repetitive carbohydrate structures on the target cell surface 2219 8547 5648 2220 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_118638.5 Downstream signaling events of B Cell Receptor (BCR) 5711 6199 5710 5714 3815 5713 5719 8945 2932 23198 23035 572 6500 5715 5716 2064 5701 1950 7311 5696 1026 5687 5695 5700 5694 3265 5717 5718 145957 2931 5688 1027 5689 8503 1956 8454 2309 5156 8660 7409 2069 26523 5155 5720 7316 10213 7249 5698 2475 5699 1839 3932 23239 842 143471 1147 5721 50852 6233 253260 1385 940 3084 685 942 941 3845 84335 64223 4893 26281 101060747 10818 4193 9542 930 5170 5159 23112 57761 10718 8915 2247 84433 2246 8517 2249 10197 2255 10125 5707 8823 5579 5706 23291 5709 27006 5966 5708 5690 2251 2252 5705 5691 2254 5704 7314 2248 8817 5692 5693 8074 5702 10892 122706 5970 5686 4794 5685 4792 5682 4793 9861 4790 9491 25780 6885 5684 3551 5683 2549 5291 5293 27161 3667 2534 5728 117145 79109 5290 4343 5781 3164 152831 2264 9965 57690 5296 192669 5295 10000 192670 207 208 2308 27327 PI3K CASCADE%REACTOME%REACT_976.2 PI3K Cascade 1796 29904 6198 7248 51719 81617 101930123 6794 5565 5564 5563 5562 92335 5571 2549 5291 3667 117145 54106 55437 6009 5290 51422 57521 53632 1978 8660 5781 1977 1975 7249 5289 6194 2475 30849 152831 2264 9965 5140 64223 101060747 26281 10818 5296 1981 5170 57761 5295 2247 2246 2249 2255 8823 27006 208 2251 2252 2254 2248 8817 8074 5494 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_169263.2 TGFBR1 KD Mutants in Cancer 1030 1875 1874 3065 1025 1024 7048 56288 7046 60436 5045 7040 54778 9040 56937 7311 100527943 11171 142 904 51377 57154 23645 905 64750 7029 2280 4088 7316 4089 9110 9958 5590 7027 57530 5499 6233 4087 25805 23327 4609 50855 387 4221 10273 7050 6667 51592 6497 50848 5054 6498 892 4092 7323 3726 7321 5500 867 5501 7314 9612 9611 25937 8239 5933 4738 101929368 23370 5494 7514 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME%REACT_834.2 RNA Polymerase II Transcription Initiation And Promoter Clearance 728340 6877 51616 1022 2968 6881 2967 6878 5438 6875 5439 5436 6880 902 6883 6884 6882 5437 5434 5435 2957 5431 2959 2958 5433 5430 5432 6872 6874 2960 2961 2962 2963 5440 5441 6873 138474 4331 2068 102157402 2071 83860 6908 2965 2966 DIGESTION OF DIETARY CARBOHYDRATE%REACTOME%REACT_9472.2 Digestion of dietary carbohydrate 6476 648740 8972 277 278 276 279 11181 3938 280 TOLERANCE BY MTB TO NITRIC OXIDE PRODUCED BY MACROPHAGES%REACTOME%REACT_120983.3 Tolerance by Mtb to nitric oxide produced by macrophages MITOTIC ANAPHASE%REACTOME%REACT_1275.3 Mitotic Anaphase 5711 6232 5710 5714 5713 5719 23198 5715 5716 5701 7311 5696 5687 4001 23047 5695 5700 55746 5885 5694 5717 5718 5688 9126 5689 2491 57082 246184 23244 5720 7316 10213 5698 5699 143471 5721 6233 5905 5519 5518 5515 5516 10726 5347 5529 5528 5527 10197 5707 5525 5706 5709 5708 5690 5705 5691 7321 5704 23122 5526 7314 5692 5693 23332 5702 122706 5686 5685 5682 9861 9491 8815 8243 5684 5683 57405 996 1058 80152 83540 7324 9184 991 699 23592 1062 1063 1060 151648 9183 9232 348235 81565 25909 55166 3796 730268 5903 57551 8379 51433 79019 55920 11130 100527963 5048 22919 23421 11065 55143 55839 91687 23141 64105 81930 79172 29882 6249 9212 7443 8697 80776 29945 4085 84643 3619 9793 51529 25936 401541 11243 100526739 147841 5520 23279 9700 151246 79902 220134 6396 701 10393 348995 378708 23063 113130 51434 55055 54821 54820 11004 9735 79980 221496 79003 2010 64682 5501 10735 79682 64946 54908 10274 10403 332 8881 57122 79023 7514 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_12623.2 Generation of second messenger molecules 3115 9402 100509457 3117 28577 3119 3118 916 915 3702 5063 7454 5062 27040 100507709 55740 3113 51466 4690 3122 5058 920 917 100996809 100507714 101060835 3120 2533 3123 28639 7408 3937 5335 7535 28755 3125 3126 3127 3932 PRPP BIOSYNTHESIS%REACTOME%REACT_850.6 PRPP biosynthesis 5634 221823 5631 PKB-MEDIATED EVENTS%REACTOME%REACT_456.4 PKB-mediated events 29904 6198 7248 51719 81617 101930123 6794 5565 5564 5563 5562 92335 5571 5140 64223 1981 55437 6009 51422 57521 53632 1978 1977 1975 208 7249 6194 2475 5494 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_150421.2 Cohesin Loading onto Chromatin 23047 5885 23383 10735 23063 25836 9126 10274 8243 23244 PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME%REACT_23946.1 Prostacyclin signalling through prostacyclin receptor 2785 2786 51764 2783 2784 2787 59345 2782 2788 94235 2791 55970 5739 54331 2778 2793 10681 2792 2790 METABOLISM%REACTOME%REACT_111217.3 Metabolism 6794 5565 5563 51422 6527 23563 8604 857 2239 221823 3373 79586 2646 9469 3339 9653 3340 92579 4191 883 11285 4190 8395 10165 10678 9435 378884 10675 3320 100500810 3795 2632 283464 8372 100616124 6120 9957 11041 9956 9955 633 2806 2805 11046 79369 27087 5255 5256 347734 5257 11081 5214 229 226 411 176 178 6382 643853 5236 648740 6385 26035 8841 8644 10855 2821 10861 2262 3101 60495 101929036 5213 5210 5208 5207 5211 5209 6548 5034 277 278 56548 276 2542 266722 10402 280 22856 5837 5834 279 5836 292 291 6576 6517 5260 293 2799 57818 5053 8692 6523 6526 6524 26229 5261 230 5499 5634 7167 166012 11261 3161 113189 2027 2026 9951 9953 2033 9672 2597 151056 2331 2584 2582 1464 2592 5631 1462 1468 3837 5406 4166 79411 10331 3099 3098 6616 3945 3949 126792 3073 3074 2538 2539 3038 9394 8972 3037 3036 2720 11181 2719 727936 4958 1645 784 3425 1634 3423 783 9348 4036 4023 63827 8908 8509 8702 8704 8703 9331 1208 9334 4969 2997 2998 10057 29940 2990 64579 2132 2131 5106 5105 960 55454 6888 6476 10082 6482 6483 6487 6484 55276 1836 2992 2023 2657 29956 135152 259230 55331 10715 79603 8879 8877 5587 9218 123099 340485 8613 91012 253782 51363 56848 56261 5223 8605 5224 5226 10558 2531 9217 2203 9517 8612 204219 151742 8611 81537 125981 55304 8560 10894 5230 200010 55576 8402 375 6448 8789 337876 90161 26330 22934 776 64711 375790 5549 1463 4669 775 1109 51000 8534 50515 7957 4060 5507 9060 5500 5501 55790 7086 2683 92126 130367 55501 1455 166929 9061 5007 54480 3938 5711 5710 5714 5713 5719 23198 5715 5716 5701 7311 5696 5687 5695 5700 5694 5717 5718 5688 5689 5720 7316 10213 5698 5699 143471 5721 6233 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 5684 5683 25796 336 337 221914 222537 93010 345 10090 348 3292 344 55746 29079 6256 6604 9883 80205 9862 90390 51003 23646 3290 80736 539 2954 2952 22901 2953 2947 2948 2941 2944 100130460 2940 79814 3293 23165 3283 2950 113451 3284 6898 522 5337 521 101929857 5338 5333 5330 3242 2110 5332 5331 2108 2109 978 3251 2946 9 549 2949 6667 1431 513 1841 5346 518 517 129401 516 515 514 339221 170685 22908 1892 1387 126969 79887 79888 2168 11145 8942 101929829 6005 5805 340075 2167 6819 29968 9377 6812 3248 586 5320 5322 5319 8202 587 2987 1806 1800 10975 1807 728441 93492 5305 134429 7004 7005 7003 84246 5578 96764 11097 79718 23511 5903 9477 5901 9631 112950 9439 9443 9441 9442 9440 8021 6095 85441 23636 8463 2101 10762 8480 348995 53371 4927 8086 9572 79023 2 100532726 4722 57678 653365 4726 4723 4720 4725 271 272 5831 64600 64210 5019 270 5443 6581 6582 55066 26873 5833 57153 54539 6580 50487 50484 50486 242 137964 240 241 6521 5498 1040 239 1036 55090 246 247 151531 6539 6538 6535 6534 92086 262 231 57128 6528 57107 283748 5092 8897 5860 101928830 50814 64241 5471 6844 64240 5476 6804 57104 1081 81490 54988 6916 1071 10229 1491 23262 3158 116228 1545 1544 3163 3162 1537 3157 1548 100996782 1551 79944 101930400 1543 1549 6901 2618 1559 1565 635 1555 1553 1557 1558 66002 4731 4329 117283 4728 5335 55627 4724 5336 4729 3613 3612 3615 3614 81894 5409 5407 5408 253430 2581 10249 3620 4759 4758 253017 114971 11343 51582 9997 2593 1056 130013 23236 3628 23305 10157 125061 3155 116285 79993 79143 9926 7296 7298 2641 2642 7295 682 2643 2644 51141 9453 51144 9468 8801 7263 23761 120227 23760 8800 8802 8803 340481 57761 27430 54905 6999 9412 645 1562 9415 1572 2053 644 1571 10682 2638 54947 2639 1503 9023 9420 9429 10166 2629 2628 6945 4830 4831 3145 4837 10162 8394 4833 11283 8396 100287413 8398 8399 1158 1159 377 57019 353 55967 5198 64768 27063 8871 1160 204962 51166 8867 203 204 1120 27109 57546 1119 55588 384 383 84618 84245 1152 8776 376497 137872 84649 64781 56474 146850 9495 154141 27034 26230 51128 51129 56894 8826 56895 255189 9489 5009 10632 84803 127281 5906 211 115677 210 212 217 216 51196 27089 254531 622 101928916 223 8833 10606 10654 7252 3931 2679 3939 3930 51686 161823 23396 23389 4082 55512 201164 51660 55500 4860 3633 10380 2678 1584 1585 1586 54898 221357 1588 9871 1589 84693 1595 1592 6609 1591 1594 133522 1593 5162 169355 5163 5160 100652777 5166 5164 5165 6697 51204 4952 1131 389434 1103 30814 55190 27124 147323 3990 126328 4051 4048 113612 3992 3991 2686 3972 30833 2687 4056 285362 51647 4862 4907 9524 6241 2729 9536 6240 3040 3043 56953 9108 2712 2717 2710 777 773 3039 6610 6611 54498 1583 1581 1580 1576 1573 1579 4899 3081 1577 150763 23054 3067 79071 2730 4946 1646 4018 4942 3419 3418 1644 9167 3033 3032 3030 4947 2766 9575 10001 3028 3034 788 79642 1666 9107 3421 3422 79644 4953 1633 1635 83549 1632 9562 2776 100526794 790 83990 29796 51241 50640 2746 9551 4047 2740 55256 7372 7384 81857 8720 27158 100507353 7371 7378 1610 162417 79017 2760 2767 2769 9807 3420 1629 7175 23446 2744 2745 2752 29785 56994 1621 1490 7352 85465 8424 7350 55224 131669 10728 51292 5298 5294 131870 5297 84274 9612 374291 7357 23225 9611 7351 7390 10498 4967 7381 5130 7388 7389 7385 7386 8760 319 341392 55217 27165 55902 51586 10499 55270 8050 23498 498 26275 51703 64816 95 2395 10411 6907 27235 51733 348158 7108 64428 26279 51312 8659 6303 8694 6307 6309 26227 57834 27233 51727 5288 27242 5660 5287 6342 91734 9261 51750 6341 47 4535 80339 124975 4539 100616403 4537 4536 4598 10400 10825 84532 4143 11112 50 4144 23474 92292 10423 26289 8681 26251 4597 471 23097 100 23279 10802 91703 79902 10427 51302 162466 64419 2326 22 116519 4514 7179 4508 2328 2327 51763 10476 4509 9282 4507 7173 7172 54797 123876 89874 728294 19 15 89869 23007 5625 10 64834 10434 54363 892 4547 4540 9968 4538 4129 4541 9969 1743 56267 6716 9677 6715 653689 1734 54704 6713 1733 1737 1738 9688 219970 1735 9663 6718 3767 11069 35 36 9972 33 34 37 83401 38 4519 10484 43 7166 5641 4513 4512 3790 80271 340665 80270 191 2819 10390 100500832 122618 83884 6723 6721 9619 9630 100302263 9615 2271 2274 9632 122622 29841 875 873 1785 654364 100137049 9254 219541 548596 101929716 9651 4199 11010 2864 6799 2235 10841 246181 100861540 126410 130 131 2879 2877 284541 2876 2875 2222 84987 2224 2232 2230 55326 132 445 440 124 445329 60481 123 127 101927622 125 126 847 801 10858 805 435 808 101928625 6390 6392 438 6391 189 5243 9123 6389 23539 427 6566 183 51380 2820 58472 27284 416 415 410 414 412 5244 58478 51360 1327 1717 1718 406 1716 23533 23530 1723 150 1728 152 6785 6783 1329 400569 10891 6770 1355 121278 129642 158 159 7498 57704 51447 1373 1371 51070 1353 51079 51074 26119 51478 22949 51477 1337 6518 1374 10101 25874 5465 1350 64900 64902 8574 590 593 1352 1024 1351 1340 57733 25870 91227 22937 1349 1345 347527 4696 5467 4695 25830 5469 4694 1381 1382 1375 5468 1376 10128 8564 27306 54205 285521 51805 23590 594 153642 5730 64180 5723 7084 64174 4682 7083 51004 8529 4698 5577 4697 22978 22977 10554 10555 4258 5576 23179 5573 23175 5568 23171 5567 56624 5566 7054 54675 56623 3705 3704 3707 3706 56603 4259 358 4257 5575 196743 4711 93034 11165 6861 8648 55748 51085 3712 5742 113026 51099 3747 10413 3745 253558 123745 144193 81579 4702 4701 1890 4700 4716 80765 4718 4717 4712 4719 4713 10025 11164 4714 11163 4710 4715 9391 6837 506 509 6834 4709 6833 501 4707 4708 2938 2939 4706 4704 2937 4705 112812 25937 440567 6817 6818 2182 2181 57122 2184 2180 3638 6822 6821 9380 25942 3635 3636 3632 9791 54576 54490 54600 54579 7358 54577 54578 574537 101929773 8503 5424 2817 7365 2068 7360 10720 23169 7367 54657 7363 7364 54659 7366 10941 54658 5593 51764 2791 3708 3709 5519 5518 5515 5516 2778 10681 200895 5528 6515 6513 93100 5167 55788 8884 80308 5740 1528 79717 4363 1582 2194 1727 10135 686 64802 10243 79646 5291 5293 5728 5290 59345 2172 6555 10599 570 213 345274 8647 4846 28234 5321 8714 3710 9971 6554 10998 6579 2785 2786 2783 2784 2787 2788 55970 107 108 54331 2793 109 2771 2792 2790 2770 2782 8976 6383 112 115 114 94235 111 113 196883 3295 215 1384 26061 8540 10005 23417 10478 11001 8310 8309 30 23600 760 766 771 765 11238 763 100507258 377677 759 768 23632 762 761 54677 84188 5264 1312 8443 55711 4128 3417 55191 4552 1719 4548 32 4594 31 23475 9446 5743 5646 8029 5645 55229 5644 25974 55312 81034 316 53354 55163 8034 6947 10560 3630 55034 81693 9962 3141 9963 56922 60496 60490 27010 8566 166785 23057 5095 948 326625 335 5096 338 101929880 440387 101928493 6948 6470 1504 51293 349565 80025 64087 3631 285540 4338 27249 9110 4524 5289 54 6573 8898 51248 5286 113278 80347 8821 101928717 30849 2694 55697 5091 55300 4522 4534 119391 200576 113235 9896 55361 27304 4801 65220 4802 80704 4800 79178 5296 5295 207 6514 2645 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME%REACT_24019.3 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 2864 51764 139760 1045 338557 2784 60559 1803 2922 3952 2641 5080 346562 28972 5122 23478 9789 90701 6934 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_15370.2 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell 5582 2902 2904 3265 112 115 114 94235 3773 111 113 346562 23229 196883 814 2570 23236 5894 5578 801 1144 805 55584 51764 808 2897 1385 2898 80852 88 1146 1145 27092 2791 816 817 818 10142 101929306 23426 815 2892 1135 2891 5923 2905 1134 101060747 1136 2906 4193 1137 2901 10681 1139 5170 2903 2893 2899 1138 8973 6237 83988 10369 10368 1741 1742 5579 1143 673 6195 1141 1142 6197 4646 2900 6196 2890 4747 9463 5594 2036 84254 1739 89832 4905 160 9495 59345 5568 5567 5566 27330 101930324 59283 2785 2786 2783 3760 3761 2784 2787 2788 5330 2560 2561 2562 2569 5331 2567 2566 100996843 200959 2557 2554 2556 3759 55970 2559 107 2558 5924 108 54331 2793 109 2771 2792 2790 2770 3768 3766 100134444 3763 3765 2782 3772 9568 3762 2774 2550 2555 55879 2773 ERK ACTIVATION%REACTOME%REACT_1482.5 ERK activation 7297 983 5781 3569 3717 3570 5594 3716 5604 5605 5595 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_121324.2 Acyl chain remodelling of PG 79888 100652777 9926 255189 64600 30814 26279 81579 283748 5320 5322 5319 8681 5321 54675 254531 50487 100137049 8399 POLYMERASE SWITCHING%REACTOME%REACT_1792.3 Polymerase switching 5422 5111 5982 5981 5983 23649 5557 57804 5558 5425 5424 10714 5985 5984 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_169121.3 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 8091 3009 3007 3008 25842 3024 3159 7290 23523 5925 57634 3005 3006 29855 7157 4001 SIGNALING BY NOTCH1%REACTOME%REACT_118859.2 Signaling by NOTCH1 3066 3714 6868 3065 3280 6907 54492 1024 7089 408 409 7088 23462 6500 3091 7311 2648 8650 83464 113878 10014 51107 1272 8454 9794 26508 10013 102 84441 101928143 23493 4851 8788 5664 7316 142678 22938 9759 9978 10046 7091 54567 57534 83737 6233 51564 55851 79885 4609 9148 2033 55869 55534 182 892 8841 101930388 3516 28514 388585 83933 9734 1387 7314 9612 9611 92737 1840 8850 79718 23220 23385 OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME%REACT_9398.3 Oligomerization of connexins into connexons 2697 2706 2705 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME%REACT_1597.3 Transport of Mature mRNA derived from an Intron-Containing Transcript 6428 9939 6429 6430 10250 10762 6432 6431 55746 5903 8480 4116 1977 11338 7307 8683 9785 23165 23279 10482 79902 348995 9631 693221 53371 4927 10189 8021 8086 7175 9883 129401 55110 10921 22916 9295 9688 283459 4686 23225 9972 11097 57122 51362 6427 6426 23511 79023 65109 23636 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME%REACT_397.2 Post-Elongation Processing of Intron-Containing pre-mRNA 100302196 6428 6429 9939 693221 51692 6430 10250 6432 6431 10189 11051 55110 53981 8106 22916 10921 4116 9295 11338 7307 283459 8683 4686 9785 10914 1477 79869 51362 1478 6427 29894 6426 10978 51585 100126351 65109 1479 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME%REACT_1195.5 Insulin receptor signalling cascade 1796 29904 6198 7248 51719 81617 101930123 6794 5565 5564 5563 5562 92335 5604 5571 5605 2549 2887 5291 53358 3643 25759 3569 1398 3667 3630 3570 3265 117145 54106 55437 6009 5290 51422 57521 53632 1978 8660 5781 1977 1975 7249 5289 6194 983 2475 30849 6464 5894 152831 2264 9965 7297 5140 7529 3845 64223 4893 26281 101060747 10818 3717 5296 1981 5170 3716 57761 6654 5295 5595 2247 2246 2249 2255 8823 27006 208 2251 2252 2254 2248 8817 8074 5594 5494 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_169439.2 Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE 55191 4552 1719 4548 32 4594 31 23475 9446 5743 5646 8029 5645 55229 5644 25974 55312 81034 316 53354 55163 8034 6947 10560 55034 81693 9962 3141 9963 56922 60496 60490 27010 8566 166785 23057 5095 326625 5096 101929880 440387 101928493 6948 6470 1504 51293 349565 80025 64087 4338 27249 4524 54 6573 51248 113278 80347 101928717 2694 5091 4522 119391 113235 27304 65220 80704 79178 200895 6515 6513 93100 5167 55788 8884 80308 5740 1528 79717 4363 1582 2194 1727 10135 686 64802 10243 79646 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_9396.4 FGFR ligand binding and activation 152831 2247 2264 9965 2246 2249 2255 8823 27006 2251 2252 2254 2248 8817 8074 26281 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_121100.2 Linoleic acid (LA) metabolism 215 9415 54898 3992 2180 60481 100302263 SIGNALING BY WNT%REACTOME%REACT_11045.5 Signaling by Wnt 8335 8334 54894 653604 3065 8337 8331 255626 51699 123169 2535 1857 8358 333932 1856 8352 8359 8324 144165 8353 8354 23513 8338 8339 474382 1855 8357 8356 4919 8347 1213 80351 1212 8348 5592 9559 8345 8346 8340 11197 7976 23002 6259 5216 9101 57216 2780 8343 2775 8344 51701 8341 4920 8342 3021 5593 4609 3020 51764 4040 50855 56998 85236 8968 2791 8360 9736 8362 8361 4221 3708 8364 3709 54145 283149 8295 8363 815 8365 8366 5519 8970 8368 5518 8349 83999 8367 5515 8085 100616282 5516 1211 8351 10681 8350 4041 23112 8355 3013 5529 3012 5528 5527 5579 5525 8452 723790 126961 8294 5526 554313 121504 3015 3014 8370 84870 3018 3017 6885 8313 160 55366 59352 163 409 161 340419 7480 7481 7482 7483 7484 607 128312 8323 8325 8321 8322 59349 4343 50999 59345 1173 7015 26108 1175 22943 3710 2785 2786 2783 440193 2784 8549 2787 2788 5330 27123 5331 10524 27121 6422 5534 55970 7534 54331 2793 2792 6423 2790 1387 5530 5532 2782 27327 9070 8290 89780 1455 55737 7514 5711 5710 5714 857 5713 8607 1452 5719 8945 2932 7089 23198 5582 139285 7088 6500 5715 5716 1499 5701 7311 5696 5687 5695 5700 166 5694 5158 6932 6934 5879 5717 8395 5718 5688 5689 5145 8454 8312 64750 79971 94235 79577 5148 26523 5720 7316 10213 324 5698 83439 9978 5699 7090 7091 10023 143471 23236 5721 6233 5578 801 805 808 101929777 343637 51384 6597 1487 1488 23401 10197 50964 5929 5707 5706 5709 5708 5690 7471 5705 5691 7476 5704 7314 5692 5693 5702 7473 7474 7477 122706 7478 7479 7472 5686 5685 5682 9861 9491 7475 51176 5684 5683 23072 84133 331 284654 25776 27161 8724 57154 57680 8658 81029 90780 51339 387 5881 57690 5880 2033 101927462 1454 4775 1459 192669 1457 81847 192670 64840 4773 4772 207 208 1460 7855 79412 54361 80326 80319 REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME%REACT_2020.4 Reversal of Alkylation Damage By DNA Dioxygenases 121642 221120 APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME%REACT_13579.1 Apoptotic cleavage of cell adhesion proteins 1829 100506658 1832 1830 1828 9414 5317 999 836 7082 G1 S TRANSITION%REACTOME%REACT_1783.2 G1 S Transition 5711 5710 1017 6241 5714 5713 1022 5719 6500 902 5715 5716 5701 7311 5696 5687 1026 5695 5700 1163 5694 5717 5718 5688 5689 1027 8454 5111 8900 6502 5001 4999 5000 7465 4998 4331 5720 4171 7316 5426 10213 4176 983 5698 890 4174 5699 4175 7027 4149 23595 990 5721 993 6233 4609 7298 5519 5518 5515 5516 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 5686 5685 5682 9861 9491 5684 5683 1719 9134 898 5925 26271 55388 8317 10926 7084 29935 9088 891 28227 6119 6118 6117 5422 84515 4173 23594 4172 5427 23649 5557 5558 1869 8318 81620 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_160113.2 Nuclear Envelope Reassembly 4001 5518 23141 5515 221496 5520 2010 23592 7443 8815 XENOBIOTICS%REACTOME%REACT_13543.3 Xenobiotics 1562 1572 64816 100861540 1571 101929829 1544 1548 1551 1543 1576 1549 1573 1559 1565 1577 1555 1553 29785 1557 54905 1558 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_20661.2 CREB phosphorylation through the activation of CaMKK 801 805 808 1385 84254 814 SEROTONIN RECEPTORS%REACTOME%REACT_17064.1 Serotonin receptors 3352 3356 3351 3355 3354 3358 3357 3350 3360 3361 3362 3363 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%REACT_6788.8 MyD88:Mal cascade initiated on plasma membrane 5604 5605 7311 3569 3570 9261 3656 23118 51295 7336 1845 5781 948 1848 3654 1849 6288 7099 466 11213 1846 2353 695 7097 10454 100996792 929 7316 246330 64127 5608 7867 983 6285 4791 5598 177 8651 5599 114609 1660 7334 7335 1147 6283 6233 7189 5606 9252 7297 4214 23643 1385 10333 5601 57161 5602 10392 1386 51135 57162 3146 2002 8767 1432 4615 257397 5519 6416 3725 59307 5518 4205 351 5515 5516 4208 3717 3716 5595 5600 5528 8517 6195 6197 7314 6196 5970 5594 4792 4793 5609 4790 6885 3551 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME%REACT_15451.2 Loss of proteins required for interphase microtubule organizationåÊfrom the centrosome 11116 5048 22919 3320 5577 9793 5566 983 1781 1778 203068 9662 22897 10733 7531 80254 11064 10121 10142 7532 55142 4957 7840 5108 1453 22994 5518 80321 9702 121441 4751 1454 7277 1069 10806 8481 22995 55722 8655 55835 5347 55125 80184 10383 54820 79959 10382 10540 11190 8636 9814 9738 22981 55755 7283 84131 23332 5116 95681 11258 7846 DEGRADATION OF GABA%REACTOME%REACT_23964.1 Degradation of GABA 18 7915 SIGNALING BY BMP%REACTOME%REACT_12034.2 Signaling by BMP 64750 7323 7321 650 4089 64388 11167 9765 6497 4090 4093 4086 4091 659 657 4092 658 93 57154 92 9241 91851 9350 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME%REACT_19118.1 SLC-mediated transmembrane transport 3099 3098 55746 2538 1317 10999 57468 11309 160728 7779 7781 6547 27173 10864 7780 57084 254428 28965 55244 55356 53919 10568 92745 6559 57181 55343 85413 6543 10559 6527 222962 55630 5002 57030 7175 9883 8671 23446 26266 54716 283652 64116 6557 6558 206358 84679 6515 115019 6513 4891 23516 10991 8884 23657 7355 55117 84889 9197 64078 10479 1811 23225 10723 55867 124935 9990 56301 23169 28231 348932 51296 25769 30061 9497 8501 115584 60482 64849 65010 1836 57282 9498 80736 200010 10599 6556 213 345274 23165 28234 6546 23279 79902 6579 6581 6582 57153 6580 129401 51000 6521 55676 126969 148867 169026 6539 6005 6538 6534 9688 6528 9972 64924 2646 92579 100616124 11046 347734 9194 9123 23539 6566 8021 10861 3101 56606 11097 6531 23511 6518 66035 23636 155184 6548 7922 6583 81031 83697 55315 153201 6578 84912 6550 2542 117247 29985 204962 23315 10762 9152 6553 9056 9057 9154 9153 9058 5172 29988 29986 5903 9356 6549 6560 101930184 6561 6564 376497 6563 284111 6565 23443 389015 8480 11182 6505 6506 55089 57835 121260 6517 6509 6512 283375 6522 6520 6575 57818 11254 6519 84102 123041 6570 6574 6571 6523 54407 81539 6526 51248 551 8170 6524 114134 6568 25800 6569 9376 11136 6584 57419 348995 23428 116085 6530 91749 9843 1356 9631 6533 51458 340024 53371 8140 6541 80024 146802 6529 26503 4927 115111 246213 2030 154091 285195 3177 6540 6536 8086 101930602 6511 6508 6507 142680 57127 353189 6510 140679 9187 6514 1468 2645 57122 79023 DEATH RECEPTOR SIGNALLING%REACTOME%REACT_1619.4 Death Receptor Signalling 8717 6868 7132 355 7186 8772 8837 356 8737 8795 841 843 8743 7124 INSULIN-LIKE GROWTH FACTOR-2 MRNA BINDING PROTEINS (IGF2BPS IMPS VICKZS) BIND RNA%REACTOME%REACT_22166.3 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs IMPs VICKZs) bind RNA 10644 10643 10642 REGULATION OF THYROID HORMONE ACTIVITY%REACTOME%REACT_15297.1 Regulation of thyroid hormone activity 1734 1733 1735 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_169313.2 Defective MUT causes methylmalonic aciduria mut type 55191 4552 1719 4548 32 4594 31 23475 9446 5743 5646 8029 5645 55229 5644 25974 55312 81034 316 53354 55163 8034 6947 10560 55034 81693 9962 3141 9963 56922 60496 60490 27010 8566 166785 23057 5095 326625 5096 101929880 440387 101928493 6948 6470 1504 51293 349565 80025 64087 4338 27249 4524 54 6573 51248 113278 80347 101928717 2694 5091 4522 119391 113235 27304 65220 80704 79178 200895 6515 6513 93100 5167 55788 8884 80308 5740 1528 79717 4363 1582 2194 1727 10135 686 64802 10243 79646 CLASSICAL KIR CHANNELS%REACTOME%REACT_75870.1 Classical Kir channels 3768 3770 3759 3761 100134444 100996843 VASOPRESSIN-LIKE RECEPTORS%REACTOME%REACT_17041.1 Vasopressin-like receptors 553 551 5020 552 554 5021 TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME%REACT_75819.1 TWIK related potassium channel (TREK) 54207 50801 3776 ACTIVATED TLR4 SIGNALLING%REACTOME%REACT_6890.10 Activated TLR4 signalling 330 148022 7322 329 10010 11035 5604 7187 9641 5605 100302736 7311 3656 23118 51295 7336 1845 1848 3654 1849 7099 466 11213 1846 2353 695 7097 10454 100996792 3665 929 7316 246330 64127 5608 983 7867 3661 6285 353376 29110 4791 7098 5598 177 8651 5599 114609 1660 7334 7335 1147 6283 6233 7189 7297 1385 1432 5519 5518 5515 5516 3717 5595 5600 5528 7323 8517 6195 7321 6197 7314 6196 5970 4792 5594 4793 4790 6885 3551 3569 3570 9261 948 5781 6288 5606 9252 4214 23643 10333 5601 57161 5602 10392 1386 51135 57162 3146 2002 8767 4615 257397 6416 3725 59307 4205 351 4208 3716 8772 8737 841 5609 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_6804.2 Regulation of Glucokinase by Glucokinase Regulatory Protein 9631 53371 2646 10762 4927 55746 8021 8086 5903 9883 7175 129401 8480 9688 23225 2645 9972 23165 11097 57122 23279 79902 23511 79023 348995 23636 PHOSPHO-PLA2 PATHWAY%REACTOME%REACT_15466.2 phospho-PLA2 pathway 5321 5594 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_7987.3 Polymerase switching on the C-strand of the telomere 5422 5111 5982 5981 5983 23649 5557 57804 5558 5425 5424 10714 5985 5984 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_169403.2 Defective BTD causes biotidinase deficiency 55191 4552 1719 4548 32 4594 31 23475 9446 5743 5646 8029 5645 55229 5644 25974 55312 81034 316 53354 55163 8034 6947 10560 55034 81693 9962 3141 9963 56922 60496 60490 27010 8566 166785 23057 5095 326625 5096 101929880 440387 101928493 6948 6470 1504 51293 349565 80025 64087 4338 27249 4524 54 6573 51248 113278 80347 101928717 2694 5091 4522 119391 113235 27304 65220 80704 79178 200895 6515 6513 93100 5167 55788 8884 80308 5740 1528 79717 4363 1582 2194 1727 10135 686 64802 10243 79646 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_169312.2 Defective HLCS causes multiple carboxylase deficiency 55191 4552 1719 4548 32 4594 31 23475 9446 5743 5646 8029 5645 55229 5644 25974 55312 81034 316 53354 55163 8034 6947 10560 55034 81693 9962 3141 9963 56922 60496 60490 27010 8566 166785 23057 5095 326625 5096 101929880 440387 101928493 6948 6470 1504 51293 349565 80025 64087 4338 27249 4524 54 6573 51248 113278 80347 101928717 2694 5091 4522 119391 113235 27304 65220 80704 79178 200895 6515 6513 93100 5167 55788 8884 80308 5740 1528 79717 4363 1582 2194 1727 10135 686 64802 10243 79646 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_121256.3 Phagosomal maturation (early endosomal stage) 4842 4843 527 528 1535 526 525 1536 523 9114 653361 529 9296 51382 50617 23545 4057 4689 10312 4688 245973 8992 245972 127124 101927180 533 534 535 90423 51606 820 155066 6556 9550 4846 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_200857.2 Epigenetic regulation of gene expression 3066 728340 8335 8334 1022 653604 3065 8337 11176 8331 902 30834 255626 3720 8358 333932 8352 8359 9013 8353 8354 9014 8338 8339 677805 9533 474382 4331 8357 8356 8347 23411 8348 8345 7270 8346 6908 8340 79101 10849 8343 8344 8341 8342 6839 3021 64425 3020 692063 8726 85236 2968 2967 8968 8360 8362 8361 100302240 84172 8364 54145 8363 8365 8366 8970 8368 8349 8367 100616282 5928 8351 654320 8350 9015 25885 8355 3013 3012 51082 692072 5440 677822 8932 723790 5441 80312 126961 8294 5252 7343 677792 2068 2071 5931 554313 121504 3015 3014 8370 3018 2965 2966 3017 23512 23309 51742 22823 5437 5434 5435 128312 221830 200424 8467 8819 29115 6996 23378 54790 2146 26147 79685 1786 64426 1788 1789 10284 79595 121536 25942 TOXICITY OF BOTULINUM TOXIN TYPE A (BONT A)%REACTOME%REACT_200737.2 Toxicity of botulinum toxin type A (BoNT A) 9900 6616 9899 22987 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_118823.4 Cytosolic sensors of pathogen-associated DNA 2547 148022 11035 1499 7311 84265 4361 5437 5434 5435 661 147945 51428 55718 6778 6737 115004 81844 6288 22954 171568 81030 3428 340061 9533 11277 5591 84126 170506 3665 7316 55703 3661 6285 29110 4791 7098 177 1660 1147 6283 6233 7520 3146 2033 4615 27297 351 101060521 1387 51082 8517 5440 9208 5441 10623 7314 51728 10621 11128 10622 8737 5970 23220 4792 4793 4790 3551 FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC%REACTOME%REACT_16956.3 Formation of tubulin folding intermediates by CCT TriC 6950 347733 7280 10383 81027 10575 10382 10376 10694 22948 10381 101927137 10576 7278 84790 10574 84617 908 677812 7203 113457 7277 7846 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME%REACT_228214.1 Aflatoxin activation and detoxification 2679 64180 124975 8574 64174 95 246181 1544 91227 92086 22977 2678 4258 1576 2686 1800 2687 91703 1577 728441 1553 4259 4257 MRN COMPLEX RELOCALIZES TO NUCLEAR FOCI%REACTOME%REACT_1884.2 MRN complex relocalizes to nuclear foci 4361 4683 3014 10111 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_22126.1 Activation of Nicotinic Acetylcholine Receptors 1144 55584 1143 1146 1145 1141 1142 1135 1134 1136 1137 1139 1138 89832 8973 CS DS DEGRADATION%REACTOME%REACT_120888.2 CS DS degradation 10675 3373 1464 411 8372 1462 63827 3073 3074 1463 633 3425 1634 3423 PREGNENOLONE BIOSYNTHESIS%REACTOME%REACT_11038.4 Pregnenolone biosynthesis 147323 1583 80765 6770 231 134429 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_169192.2 TGFBR2 MSI Frameshift Mutants in Cancer 1030 1875 1874 3065 1025 1024 7048 56288 7046 60436 5045 7040 54778 9040 56937 7311 100527943 11171 142 904 51377 57154 23645 905 64750 7029 2280 4088 7316 4089 9110 9958 5590 7027 57530 5499 6233 4087 25805 23327 4609 50855 387 4221 10273 7050 6667 51592 6497 50848 5054 6498 892 4092 7323 3726 7321 5500 867 5501 7314 9612 9611 25937 8239 5933 4738 101929368 23370 5494 7514 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_1505.2 Integration of energy metabolism 3790 6616 6794 5565 5563 9630 777 773 9254 51422 2864 112 115 114 94235 111 113 196883 784 2776 783 23236 5578 51764 2740 2791 2641 2642 3708 100507353 3709 5519 5518 2767 2769 5515 5516 2778 10681 5528 150 6513 152 2194 6888 6945 5207 32 31 10411 3630 292 47 291 9495 59345 8826 5577 293 10554 5906 5576 5573 5568 5567 5566 26251 3710 5575 2785 776 2786 2783 6861 51085 2784 2787 2788 5330 4082 3747 3745 5331 55970 107 108 54331 2793 109 775 2771 2792 2790 2770 6833 2782 6514 1131 7086 6812 3767 11069 6844 6804 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME%REACT_23765.1 Reduction of cytosolic Ca++ levels 490 6547 6543 6546 491 492 487 493 489 488 VIF-MEDIATED DEGRADATION OF APOBEC3G%REACTOME%REACT_9453.2 Vif-mediated degradation of APOBEC3G 5711 5710 5714 5713 5719 23198 5715 5716 5701 7311 5696 5687 5695 5700 5694 5717 5718 5688 5689 5720 7316 10213 5698 9978 5699 143471 5721 6233 10197 5707 5706 5709 8065 5708 5690 5705 5691 5704 7314 5692 5693 5702 6921 122706 6923 5686 5685 5682 9861 9491 5684 5683 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME%REACT_281.3 RNA Polymerase III Transcription Initiation 55814 6621 9330 27297 5437 84265 5434 5435 101060521 661 7702 6619 51082 55718 9328 5440 9329 171568 5441 5451 10623 9533 10621 51728 10622 11128 10302 55703 55290 2972 2976 6908 2971 2975 6617 6618 APC TRUNCATION MUTANTS HAVE IMPAIRED AXIN BINDING%REACTOME%REACT_228196.1 APC truncation mutants have impaired AXIN binding 5711 5710 5714 5713 1452 5719 3065 8945 2932 7089 23198 139285 7088 6500 5715 5716 1499 5701 7311 5696 5687 5695 5700 166 5694 6932 6934 5717 5718 5688 5689 8454 8312 5720 7316 10213 324 5698 83439 9978 5699 7090 7091 10023 143471 5721 6233 5519 5518 5515 5516 5529 1487 5528 1488 5527 23401 10197 5707 5525 5706 5709 5708 5690 5705 5691 5704 5526 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 51176 5684 5683 FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_9416.3 FGFR2b ligand binding and activation 2246 2255 27006 2252 2248 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME%REACT_6783.8 Toll Like Receptor 3 (TLR3) Cascade 330 148022 7322 329 10010 11035 5604 7187 9641 5605 100302736 7311 3656 23118 7336 1845 1848 3654 1849 7099 466 1846 2353 10454 100996792 3665 929 7316 64127 5608 983 7867 3661 6285 353376 4791 29110 5598 7098 177 5599 1660 7334 7335 1147 6283 7189 6233 7297 1385 1432 5519 5518 5515 5516 3717 5595 5600 7323 5528 8517 6195 7321 6197 7314 6196 5970 4792 5594 4793 4790 6885 3551 3569 3570 9261 5781 6288 5606 9252 23643 5601 5602 10392 1386 3146 2002 8767 4615 257397 6416 3725 4205 351 4208 3716 8772 8737 841 5609 PHOSPHORYLATION OF EMI1%REACTOME%REACT_6875.2 Phosphorylation of Emi1 26271 51343 983 891 991 5347 PHOSPHORYLATION OF PROTEINS INVOLVED IN THE G2 M TRANSITION BY CYCLIN A:CDC2 COMPLEXES%REACTOME%REACT_6362.3 Phosphorylation of proteins involved in the G2 M transition by Cyclin A:Cdc2 complexes 8900 983 890 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_116022.2 Nuclear signaling by ERBB4 55851 2099 6868 8945 3084 685 10413 6500 83464 3717 51107 5617 9542 6777 145957 5241 6776 8454 10718 1443 23118 1444 51741 2670 6387 5781 2690 2689 2688 2069 9611 5664 6285 9978 1839 5618 23385 1447 1442 PKA-MEDIATED PHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME%REACT_1525.3 PKA-mediated phosphorylation of key metabolic factors 5568 5567 5566 51085 5207 SPHINGOLIPID METABOLISM%REACTOME%REACT_19323.4 Sphingolipid metabolism 2657 29956 259230 55331 10715 79603 8879 8877 5587 57733 9218 25870 123099 2717 340485 8613 91012 253782 347527 56848 6610 3073 10558 2531 3074 9217 9517 8612 204219 151742 5660 8611 81537 125981 55304 64781 8560 153642 55627 22901 2720 10825 79642 2581 56624 4759 4758 101927622 653365 55512 411 427 643853 416 415 2760 410 414 412 6609 339221 340075 7357 57704 2629 130367 1455 166929 79411 5007 285362 5476 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_25091.1 ER Quality Control Compartment (ERQC) 80267 55757 56886 11253 55741 9695 REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS%REACTOME%REACT_13778.2 Regulation of gene expression in early pancreatic precursor cells 3175 2255 4825 6928 390874 256297 3651 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME%REACT_15302.2 Mitochondrial tRNA aminoacylation 124454 54938 57176 57038 23438 92935 57505 79731 10352 25973 55699 27068 10667 80222 79587 51067 23395 3735 5859 55157 2617 RNA POLYMERASE I CHAIN ELONGATION%REACTOME%REACT_2204.1 RNA Polymerase I Chain Elongation 728340 8335 8334 1022 653604 8337 8331 902 30834 255626 5437 5434 5435 128312 221830 8358 333932 8352 8359 9013 8353 8354 9014 8338 8339 677805 9533 474382 4331 8357 8356 8347 8348 8345 8346 6908 8340 79101 10849 8343 8344 8341 8342 3021 64425 3020 692063 85236 2968 2967 8968 8360 8362 8361 100302240 84172 8364 54145 8363 8365 8366 8970 8368 8349 8367 100616282 8351 654320 8350 9015 25885 8355 3013 3012 51082 692072 5440 677822 723790 5441 126961 8294 11335 7343 677792 2068 2071 554313 121504 3015 3014 8370 3018 2965 2966 3017 DNA REPLICATION PRE-INITIATION%REACTOME%REACT_734.3 DNA Replication Pre-Initiation 5711 1017 5710 51053 5714 5713 5719 23198 5715 5716 5701 7311 5696 5687 5695 5700 5694 5717 5718 1871 5688 1870 5689 55388 8317 10926 29935 5001 4999 5000 6119 4998 6118 6117 4171 5720 7316 5426 10213 4176 5698 4174 4175 5699 23595 143471 990 5721 6233 5422 84515 4173 23594 4172 5427 23649 5557 5558 1869 8318 81620 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 5684 5683 SIGNALING BY NOTCH2%REACTOME%REACT_118721.5 Signaling by NOTCH2 3714 55851 1385 3280 9148 54492 2033 7311 55534 83464 182 51107 2208 4192 3002 3516 28514 1272 388585 4853 9794 102 84441 7314 5664 142678 7316 10046 54567 23385 57534 6233 TRANSLATION INITIATION COMPLEX FORMATION%REACTOME%REACT_1979.2 Translation initiation complex formation 6231 6232 8894 1965 6044 26784 26781 100505503 101929876 6043 85388 619567 1964 1968 619568 6228 6229 6227 6235 6230 7458 6234 100302143 1974 84546 1973 1977 1975 2197 3646 6193 6194 6192 6191 8669 94163 6233 8668 652965 101060318 652966 677847 574040 6224 6223 6222 8663 8661 6203 8662 6201 6202 8666 26811 8667 8665 6189 6188 8664 1981 26795 6187 27335 6210 6205 6204 6208 100996747 100508408 6209 6206 6207 6217 6218 26986 3921 8944 INFLUENZA LIFE CYCLE%REACTOME%REACT_6145.5 Influenza Life Cycle 6231 6232 5438 5439 6044 5436 26784 100505503 26780 7311 116936 26778 116938 55746 6228 6229 6227 6235 4736 6230 26771 6234 2926 84546 26809 3320 25873 2197 100124516 94163 26791 26790 6233 6224 6223 6222 821 6203 6201 6202 8021 1211 23521 7175 9883 595100 6210 2962 5440 2963 6205 5441 6204 6208 6209 23225 6206 6207 6217 11097 6218 3921 23511 6083 23636 6165 6137 6168 6136 6138 6161 6139 6164 6160 6130 6133 10762 9045 6132 6135 101929876 6167 6134 6169 85388 6143 6144 6141 6142 6147 5437 606500 5434 5903 5435 6146 619565 619499 619562 8480 100529097 11224 26819 26815 5901 26817 26818 26816 6129 51121 6128 6193 6194 23165 6192 6191 23279 26820 79902 348995 6124 6123 6122 9631 6125 9349 574040 53371 6171 6170 619505 6173 4927 100526842 6176 6175 811 26811 5611 8086 3843 26814 6189 6188 129401 5431 5433 5430 26795 6187 5432 595097 3303 595099 3836 9688 100996747 100508408 6181 3837 595098 9972 57122 6154 6155 6152 6159 3304 8944 6157 6158 79023 6156 7514 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME%REACT_8005.8 Toll Like Receptor TLR1:TLR2 Cascade 5604 5605 7311 3569 3570 9261 3656 23118 51295 7336 1845 5781 948 1848 3654 1849 6288 7099 466 11213 1846 2353 695 7097 10454 100996792 929 7316 246330 64127 5608 7867 983 6285 4791 5598 177 8651 5599 114609 1660 7334 7335 1147 6283 6233 7189 5606 9252 7297 4214 23643 1385 10333 5601 57161 5602 10392 1386 51135 57162 3146 2002 8767 1432 4615 257397 5519 6416 3725 59307 5518 4205 351 5515 5516 4208 3717 3716 5595 5600 5528 8517 6195 6197 7314 6196 5970 5594 4792 4793 5609 4790 6885 3551 INNATE IMMUNE SYSTEM%REACTOME%REACT_6802.5 Innate Immune System 4651 101930374 5603 10235 4627 4620 4153 115727 28442 403339 245908 5062 245909 28454 3093 729230 4641 5027 10006 1378 10910 117285 1398 10458 4064 644414 7410 3502 3503 414325 54106 728358 55894 3958 3501 8503 64170 26052 598 400830 55718 596 22861 64145 114548 23586 7409 26999 51517 84513 28908 9533 6300 7100 64135 10810 245929 245927 7128 245928 1235 55703 503614 503618 55593 245915 1650 5589 245911 245913 1660 7706 245910 51311 503841 147179 2219 245939 8547 245940 5648 57506 504180 2220 245930 7006 245934 245932 245937 245936 100289462 245938 23112 5595 8915 51082 84433 8517 10125 5440 6195 25 5441 6197 6196 8887 10892 2210 2207 2209 63916 28834 5970 613209 84282 2205 4792 2206 4793 735 4790 613211 26007 6885 196051 3551 2212 731 730 2214 10628 613210 3497 8411 28916 51191 10878 417 733 732 829 28912 58484 721 629 720 5437 727 5434 729 5435 722 725 713 718 715 712 7318 140881 716 717 830 23646 837 140596 7448 140850 7456 714 51284 29108 100133267 1604 100847079 28299 966 834 645832 7294 10152 84166 10787 7462 1401 5300 9474 3538 9140 9450 728489 3684 5627 10695 3004 9246 1520 100129216 3539 5337 10163 9636 5338 81622 9447 81623 8936 100423062 1793 1514 1513 3542 3689 7529 9051 644150 1515 1508 3514 79132 4179 3426 3326 28776 54941 3442 28876 3440 3441 1670 1671 1387 28874 1667 80143 3439 3451 1759 1668 1669 3443 3444 24145 3452 4644 3448 3449 3445 3446 28896 27327 81793 100293534 3660 3075 3659 1540 3456 79671 1673 1672 1675 4210 3929 55845 440786 6199 330 9402 3815 3813 57292 23601 400709 7305 5581 148022 7322 23035 5582 329 10010 572 5604 11035 3810 7187 5605 9641 100302736 2064 3805 1950 3808 1026 84265 3804 6850 3806 3803 100049587 3265 5879 145957 2931 1027 1956 3809 147945 2309 5156 51428 6778 3937 8660 6737 22914 5335 54209 115004 5336 3320 81844 22954 171568 100132285 81030 10326 5137 3428 2069 340061 26523 695 11277 5591 3133 5155 84126 170506 814 3665 3824 3822 7249 5580 342510 983 3661 353376 2475 29110 3107 7098 3106 1839 3932 284266 23239 842 1147 50852 5578 5894 253260 156 7297 100528032 100133046 940 3084 685 942 941 7295 100996743 3845 84335 27297 9436 64223 4893 101060747 3717 4193 9542 930 5170 5159 57761 10718 54210 9208 10623 10621 10622 8398 2547 10451 2033 4650 4775 6654 4773 4772 998 7186 8772 8737 841 843 23220 5609 4361 9844 3055 9846 83737 2268 3708 3709 1432 5519 5518 5515 5516 5153 5600 5528 2549 100653194 5291 5293 567 3569 3667 2534 5728 3570 117145 553128 79109 5290 4343 9261 124599 661 5781 5136 3164 3710 7520 6416 5534 107 108 109 101060521 5530 5532 5641 1072 3984 60 2932 3702 122618 5063 7454 5747 8976 1499 4690 7311 7525 5058 10093 10092 5588 10552 10097 1785 917 10096 10094 71 10109 4067 3656 23118 51295 7336 112 1845 115 1848 114 3654 1849 7099 466 11213 111 113 1846 2353 7097 10454 196883 100996792 929 246330 7316 64127 5608 7867 6285 4791 5598 177 8651 5599 114609 7334 7335 6283 6233 7189 801 805 808 1385 26281 10818 2247 7323 2246 2249 2255 8823 27006 2251 2252 7321 2254 7314 2248 8817 8074 5594 5646 5645 27161 920 5094 948 6288 5577 5576 5573 5568 5289 5567 5566 30849 5575 5606 835 152831 2264 9252 9965 4214 23643 10333 7184 5601 57161 5602 57690 10392 1386 51135 57162 3146 2002 100500842 8767 4615 257397 3725 59307 4205 351 4208 5296 192669 3716 5295 10000 192670 207 208 51728 2308 11128 FOLDING OF ACTIN BY CCT TRIC%REACTOME%REACT_17050.2 Folding of actin by CCT TriC 6950 677812 7203 60 10575 10694 22948 101927137 10576 10574 908 METABOLISM OF POLYAMINES%REACTOME%REACT_14820.2 Metabolism of polyamines 55256 6723 4507 262 79814 6303 6611 54498 4953 58478 51074 84245 113451 2805 196743 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_25085.1 N-Glycan antennae elongation 8128 2683 338596 11320 25834 8702 6484 8704 8703 9331 4249 51046 11282 6480 9334 BETA DEFENSINS%REACTOME%REACT_115897.1 Beta defensins 100129216 245939 245940 504180 613210 81623 245930 403339 245934 245908 245932 245909 245937 245936 729230 100289462 245938 117285 644414 414325 55894 140881 140596 400830 140850 100133267 7097 245929 245927 245928 1235 503614 503618 613209 245915 1673 1672 245911 245913 613211 245910 503841 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_150139.2 SHC-related events triggered by IGF1R 7297 5781 3481 5604 5605 7529 3845 53358 25759 983 3569 4893 3479 3480 3717 3265 3570 5594 3716 6464 6654 5595 5894 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME%REACT_1008.2 Glycogen breakdown (glycogenolysis) 801 805 5255 808 5256 5257 5260 178 8908 5236 5837 5261 5834 55276 2992 5836 KSRP DESTABILIZES MRNA%REACTOME%REACT_25042.2 KSRP destabilizes mRNA 5600 23016 54512 5393 118460 207 51010 23404 51013 1432 167227 22894 5073 7534 8570 56915 11340 TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME%REACT_75801.1 TWIK-related spinal cord K+ channel (TRESK) 338567 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_121092.3 Regulation of gene expression by Hypoxia-inducible Factor 2034 1387 7422 405 2056 64344 768 3091 2033 FRS2-MEDIATED ACTIVATION%REACTOME%REACT_12076.4 Frs2-mediated activation 7297 5781 5335 673 5604 5605 4803 5906 7529 3845 983 3569 4893 3717 10818 4914 3265 3570 5594 2889 1399 3716 5595 5894 INACTIVATION OF CDC42 AND RAC%REACTOME%REACT_19342.1 Inactivation of Cdc42 and Rac 80728 6091 23380 9353 9901 57522 2817 998 5879 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME%REACT_1893.3 Resolution of Abasic Sites (AP sites) 5111 2237 6996 57804 4913 4968 5425 8930 10309 4350 5424 7515 3978 23583 3980 10714 5423 328 4595 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME%REACT_2156.4 Cleavage of the damaged pyrimidine 4913 8930 10309 23583 6996 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_200731.2 deactivation of the beta-catenin transactivating complex 56998 3065 8945 331 7089 7088 4221 283149 1499 7311 25776 8085 607 7534 6932 6934 1487 57680 5929 207 208 26108 7314 9070 7316 324 90780 83439 7090 7091 51176 7514 6233 THE PROTON BUFFERING MODEL%REACTOME%REACT_6196.2 The proton buffering model 7352 7350 7351 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME%REACT_2160.2 p53-Independent DNA Damage Response 5711 5710 5714 5713 5719 23198 5715 5716 5701 7311 5696 5687 5695 5700 5694 5717 5718 5688 1111 5689 5720 7316 10213 5698 5699 143471 993 5721 6233 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 122706 472 5686 5685 5682 9861 9491 5684 5683 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_147727.2 Constitutive PI3K AKT Signaling in Cancer 6199 3815 2932 572 2064 2549 1950 5291 5293 1026 3667 2534 5728 145957 79109 2931 5290 1027 8503 1956 2309 5156 8660 5781 7409 2069 5155 7249 3164 2475 1839 3932 842 1147 50852 152831 253260 2264 9965 1385 940 3084 685 942 941 84335 64223 101060747 26281 10818 5296 4193 9542 930 5170 5159 10718 5295 10000 2247 2246 2249 2255 8823 207 27006 208 2251 2252 2254 2308 2248 8817 8074 P2Y RECEPTORS%REACTOME%REACT_18289.1 P2Y receptors 5028 5031 5032 2840 5030 27334 2846 53829 9934 64805 5029 10161 TELOMERE EXTENSION BY TELOMERASE%REACTOME%REACT_7974.2 Telomere Extension By Telomerase 8607 100847052 1736 7015 55135 10856 55651 677835 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_115993.1 SHC1 events in ERBB2 signaling 7297 3084 685 5604 5605 2064 7529 1950 3845 3569 4893 3717 3265 3570 9542 145957 3716 6654 1956 10718 5595 5781 2069 983 1839 5594 6464 5894 SYNTHESIS OF PE%REACTOME%REACT_120919.2 Synthesis of PE 1120 85465 64900 23175 1119 55224 5833 23761 10390 55500 9663 162466 FUSION OF THE INFLUENZA VIRION TO THE HOST CELL ENDOSOME%REACTOME%REACT_6351.4 Fusion of the Influenza Virion to the Host Cell Endosome SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%REACT_163812.3 SUMO is conjugated to E1 (UBA2:SAE1) 7341 10054 6613 6612 10055 101929087 DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_15293.1 Dopamine Neurotransmitter Release Cycle 6616 8541 6571 8499 9256 8224 22999 8497 10497 6853 6854 5864 6844 8500 6804 6857 10815 KLOTHO-MEDIATED LIGAND BINDING%REACTOME%REACT_111247.1 Klotho-mediated ligand binding 152831 2264 9965 8074 ABH2 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME%REACT_526.4 ABH2 mediated Reversal of Alkylation Damage 121642 NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY%REACTOME%REACT_6179.4 NEP NS2 Interacts with the Cellular Export Machinery 9631 53371 10762 4927 55746 8021 8086 5903 9883 7175 129401 8480 5901 9688 23225 9972 23165 11097 57122 23279 79902 23511 79023 348995 7514 23636 SIGNALLING TO STAT3%REACTOME%REACT_12049.2 Signalling to STAT3 6774 4914 4803 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_25046.1 Transport to the Golgi and subsequent modification 8128 4248 3998 22872 338596 11320 25834 9632 9871 8702 8704 8703 9331 4249 51046 11282 9334 6480 51128 4247 2683 57134 10113 10905 90411 79694 4122 4121 4124 2530 6484 4245 10484 10802 6396 10427 MRNA CAPPING%REACTOME%REACT_1470.4 mRNA Capping 728340 1022 2968 2967 5438 5439 5436 8731 902 8732 5437 5434 5435 5431 5433 5430 5432 22916 2962 5440 2963 6829 5441 4686 4331 2068 2071 2965 2966 TRANSCRIPTION%REACTOME%REACT_1788.5 Transcription 3066 728340 8335 8334 1022 653604 3065 5438 8337 5439 5436 10250 8331 902 30834 255626 6621 53981 8358 333932 55718 8352 8359 9013 8353 8354 9014 8338 8339 677805 9533 5451 474382 8683 11198 4331 8357 8356 6827 8347 57459 9785 8348 8345 55703 7270 8346 6908 8340 57504 79101 10849 5442 54700 64216 8343 8344 8341 100126351 8342 3021 64425 3020 692063 85236 4782 2968 2967 4784 51692 8968 8360 8362 8361 100302240 84172 8364 54145 8363 8365 8366 8970 4774 8368 8349 8367 100616282 5928 8351 654320 9112 8350 9015 25885 8355 5595 6619 3013 3012 51082 284119 692072 54815 134353 5440 677822 100302242 8932 723790 5441 126961 8294 11335 7343 677792 2068 102157402 2074 2071 5931 8850 554313 121504 9219 3015 4781 3014 8370 3018 2965 51585 6617 2966 3017 53615 6618 9939 1108 1107 2648 10919 5437 5434 5435 128312 101928686 221830 661 4116 7978 7884 11338 1477 6917 1478 1479 51616 55814 10189 8178 101060521 11051 7702 10921 9295 6741 4686 7936 6921 10914 6924 6923 29894 6428 6429 6430 6628 6432 6431 84265 6634 6635 6636 6872 6637 6874 171568 7307 6873 138474 7019 10302 100302196 6877 84967 6881 6878 6875 8731 6880 6883 6884 8732 27297 6882 2957 2959 2958 55110 8106 22916 2960 2961 2962 6749 2963 10623 10621 10622 2972 2976 51362 2971 2975 6427 6426 51497 1025 904 905 9328 7469 9329 79869 25888 10978 100126332 693221 9330 5431 5433 5430 5432 6829 25920 283459 51728 11128 9150 55290 83860 65109 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME%REACT_1697.3 Beta oxidation of octanoyl-CoA to hexanoyl-CoA 1892 34 3033 3032 3030 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_200643.2 negative regulation of TCF-dependent signaling by WNT ligand antagonists 4040 50964 27123 27121 79412 6422 7474 7483 83999 89780 22943 54361 11197 4041 6423 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_121311.2 Cellular response to hypoxia 7322 3091 2033 7311 55662 1387 2034 7422 7323 7428 405 54583 2056 112398 8453 64344 112399 7321 768 7314 7316 6921 6923 9978 6233 BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME%REACT_2108.3 Beta oxidation of myristoyl-CoA to lauroyl-CoA 33 3032 3030 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_163977.2 Regulation of innate immune responses to cytosolic DNA 147945 51428 6737 81844 22954 81030 340061 11277 7314 84126 7316 7311 3661 29110 23220 6233 PURINE CATABOLISM%REACTOME%REACT_2086.3 Purine catabolism 847 4907 93034 84618 30833 22978 4860 2876 100526794 9615 7498 PHOSPHOLIPID METABOLISM%REACTOME%REACT_120870.2 Phospholipid metabolism 81490 2819 10390 122618 9108 6901 100137049 8395 150763 8503 100500810 3032 3030 9107 55326 114971 11343 50640 79143 9926 9468 23761 23760 23446 23533 56994 85465 55224 5298 5294 54947 5297 129642 5130 8443 8760 10162 8394 8396 8398 8399 64900 377 590 8871 204962 8867 26279 1120 56261 8605 8694 5291 5293 1119 5728 5288 8776 5287 5290 84649 23646 146850 80339 80736 154141 56894 56895 255189 10400 9489 84803 10554 10555 3631 375 285540 9110 10423 23175 5289 23171 8681 5321 8898 54675 5286 56623 8821 254531 30849 55697 55300 4534 200576 162466 9896 64419 55361 57678 5337 7179 5338 23396 51763 201164 64600 253558 55500 123745 81579 151056 5833 57153 5296 50487 137964 5295 22908 1040 126969 79887 79888 100652777 11145 4952 1103 30814 9663 27124 283748 5320 5322 8897 5319 43 3635 93492 3636 5305 57104 9791 MISCELLANEOUS SUBSTRATES%REACTOME%REACT_13425.3 Miscellaneous substrates 64816 126410 101929829 8529 284541 4051 57834 1580 113612 1579 1565 29785 54905 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME%REACT_17029.2 Cooperation of Prefoldin and TriC CCT in actin and tubulin folding 6950 347733 7280 81027 60 10575 10376 10694 22948 10381 101927137 10576 7278 84790 10574 84617 908 7277 7411 10471 5202 10383 10382 5204 5201 5203 677812 7203 113457 7846 BUDDING%REACTOME%REACT_6212.3 Budding PI-3K CASCADE%REACTOME%REACT_21270.5 PI-3K cascade 6199 3815 2932 23035 572 2064 2549 1950 5291 5293 1026 27161 3667 2534 5728 117145 145957 79109 2931 5290 1027 4343 8503 1956 2309 5156 8660 5781 7409 2069 26523 5155 7249 3164 2475 1839 3932 23239 842 1147 50852 152831 253260 2264 9965 1385 940 3084 685 57690 942 941 84335 64223 26281 101060747 10818 5296 4193 9542 192669 930 5170 5159 23112 57761 10718 5295 10000 2247 2246 192670 2249 2255 8823 207 27006 208 2251 2252 2254 2308 2248 8817 8074 27327 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_121141.2 Signaling by FGFR1 fusion mutants 613 6774 8805 5335 7750 9208 11116 9846 1523 11052 26127 6777 6776 5290 6772 5295 399687 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_111118.4 BMAL1:CLOCK,NPAS2 activates circadian gene expression 5465 5187 1628 6604 8553 79365 8648 96764 8864 6907 2033 5469 5054 6095 8841 406 23054 80205 1387 10891 9575 10135 9611 10498 85441 551 79718 25819 2155 6256 1407 9572 56938 10499 2908 1408 4862 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME%REACT_19236.1 Sema3A PAK dependent Axon repulsion 1072 3984 3320 5063 5062 55558 8829 10371 5058 91584 2242 5362 5361 2534 3326 5879 AMINE COMPOUND SLC TRANSPORTERS%REACTOME%REACT_20679.1 Amine compound SLC transporters 6530 6533 51458 340024 204962 9152 6529 6582 6540 57153 6536 6580 101930602 23446 101930184 54716 57127 6563 126969 80736 6539 55117 6005 6538 6534 11254 6570 6571 348932 8170 6531 60482 O-LINKED GLYCOSYLATION%REACTOME%REACT_200727.2 O-linked glycosylation 10331 10678 79369 9331 9334 6480 100130872 94025 170690 140453 6482 6483 6487 6484 4582 79623 4586 51301 170689 118430 192134 27090 283463 10417 157869 10418 2589 171019 2590 2591 644378 7058 9037 10071 11226 168391 55901 7057 93010 92949 442117 9510 11227 26290 9508 9509 140687 9245 100528030 170691 170692 84002 23275 50614 374907 63917 2650 11095 10610 11096 11093 56913 374378 4589 80731 56999 4588 140766 79695 200958 64409 117248 57876 145173 114805 4584 4583 4585 51809 29071 8693 54437 81794 9507 256435 80070 221981 81792 55568 9719 727897 57452 11173 84752 11174 56667 146712 79875 5199 54507 101928934 100996396 339366 23145 394263 143662 57188 THE IPAF INFLAMMASOME%REACTOME%REACT_75892.1 The IPAF inflammasome 58484 834 SIGNALING BY NOTCH%REACTOME%REACT_299.6 Signaling by NOTCH 3066 3714 3065 54492 7089 7088 6500 3091 7311 113878 8454 9794 7029 26523 7316 22938 9759 9978 7027 7091 6233 83737 4609 79885 1385 9148 55534 182 8841 23112 388585 7314 9612 9611 1840 8850 79718 6487 6484 6868 3280 6907 1024 408 409 23462 5045 10402 2648 8650 27161 83464 10014 51107 2208 4192 3002 1871 1272 4343 4853 4854 4855 26508 487 10013 102 84441 101928143 23493 4851 8788 5664 142678 10046 489 488 54567 57534 51564 10959 6400 55851 5986 595 56983 4242 23509 57690 5870 3955 2033 150786 7157 3725 1869 55869 192669 892 101930388 3516 28514 9734 1387 83933 192670 92737 2683 27327 23220 23385 MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME%REACT_367.1 Mitochondrial transcription initiation 7019 5442 64216 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME%REACT_20537.1 Type I hemidesmosome assembly 3691 1308 3909 3918 3655 667 3914 977 5339 SYNTHESIS OF PA%REACTOME%REACT_120906.2 Synthesis of PA 57678 5337 5338 2819 64600 253558 26279 81579 100137049 150763 137964 79888 100652777 56894 56895 30814 84803 10554 10555 283748 5320 23171 5322 5319 55326 8681 8443 5321 254531 8399 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_200828.2 Depolymerisation of the Nuclear Lamina 64900 5579 891 221496 255919 23592 2010 23399 9663 23175 4001 983 5578 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_200834.2 Negative epigenetic regulation of rRNA expression 3066 728340 8335 8334 1022 653604 3065 8337 11176 8331 902 30834 255626 8358 333932 8352 8359 9013 8353 8354 9014 8338 8339 677805 9533 474382 4331 8357 8356 23411 8347 8348 8345 7270 8346 6908 8340 79101 10849 8343 8344 8341 6839 8342 3021 64425 3020 692063 85236 2968 2967 8968 8360 8362 8361 100302240 84172 8364 54145 8363 8365 8366 8970 8368 8349 8367 100616282 8351 654320 8350 9015 25885 8355 3013 3012 51082 692072 5440 677822 8932 723790 5441 126961 8294 7343 677792 2068 2071 554313 121504 3015 3014 8370 3018 2965 2966 3017 23309 51742 5437 5434 5435 128312 221830 8467 8819 29115 23378 79685 1786 64426 1789 10284 79595 25942 SIGNALLING TO RAS%REACTOME%REACT_12033.2 Signalling to RAS 7297 5603 5604 5605 4803 1432 7529 3845 53358 5900 25759 5898 3569 5899 4893 3717 3265 3570 3716 6654 9261 5595 5600 5781 6300 983 7867 4914 5594 6464 5894 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%REACT_1072.2 Inactivation of APC C via direct inhibition of the APC C complex 11065 51434 996 7324 9184 991 29882 7321 64682 246184 8697 29945 4085 8881 51529 730268 51433 701 10393 ACTIVATION OF TRKA RECEPTORS%REACTOME%REACT_11064.4 Activation of TRKA receptors 4914 4915 135 117 116 4803 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME%REACT_1281.4 Transport of Mature Transcript to Cytoplasm 6428 6429 9939 6430 10250 10762 6432 6431 55746 5903 53981 8480 4116 1977 7884 11338 7307 8683 9785 23165 23279 10482 79902 100126351 348995 100302196 9631 693221 51692 53371 4927 10189 8021 8086 129401 7175 9883 55110 10921 22916 9295 9688 283459 4686 23225 9972 11097 57122 51362 6427 29894 6426 23511 79023 65109 23636 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_22345.1 Organic cation anion zwitterion transport 116085 6583 10864 55356 55867 6581 6582 85413 9356 5002 6580 9376 6584 TNF SIGNALING%REACTOME%REACT_1432.5 TNF signaling 8717 6868 7124 7132 7186 8737 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_1695.3 GPVI-mediated activation cascade 391 388 387 27040 5880 5291 6850 101060747 2534 5296 7410 51206 5879 5170 4067 5290 8503 23533 5295 146850 10000 3937 207 7409 208 5336 10451 998 5294 2207 5590 3932 SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME%REACT_150292.2 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) 239 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_116005.2 SHC1 events in ERBB4 signaling 7297 3084 685 5604 5605 7529 3845 4893 3569 3717 3570 3265 9542 145957 3716 10718 6654 5595 5781 2069 983 1839 5594 6464 5894 MITOTIC PROPHASE%REACTOME%REACT_765.4 Mitotic Prophase 91754 9133 8335 5861 8334 5862 653604 10783 8337 2801 79648 81876 10592 8331 2029 10776 8615 255626 10051 4001 55746 8358 333932 8352 8359 8353 8354 8338 8339 474382 8357 8356 8347 55844 64689 8348 29781 8345 54892 26003 983 8346 23310 387893 8340 8548 8343 8344 8341 84930 8342 140609 5578 3021 3020 85236 8968 8360 8362 8361 8364 54145 8363 8365 5519 8366 8970 5518 8368 8349 5515 8367 5516 8021 100616282 8351 9883 7175 8350 8355 5347 3013 3012 5579 723790 126961 8294 23225 554313 11097 121504 3015 3014 8370 5594 3018 23511 8815 3017 23636 64900 23592 5925 10762 5903 128312 8480 891 7443 23175 23165 23279 79902 348995 9631 53371 255919 23399 4927 8086 129401 6418 221496 2010 9688 9663 8290 9972 57122 79023 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME%REACT_1069.6 PTM: gamma carboxylation, hypusine formation and arylsulfatase activation 411 25870 2147 5045 347527 1984 83475 416 1725 415 410 8858 414 412 56648 2621 2677 79001 153642 5624 22901 340075 79642 2158 2155 2159 5627 285362 MONOAMINES ARE OXIDIZED TO ALDEHYDES BY MAOA AND MAOB, PRODUCING NH3 AND H2O2%REACTOME%REACT_416.3 Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2 4128 4129 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_21328.1 MAPK targets Nuclear events mediated by MAP kinases 9252 1385 5601 5602 1386 2002 1432 5519 3725 5518 4205 5515 5516 4208 9261 5595 5600 5528 1845 1848 6195 1849 466 6197 1846 2353 6196 5598 5594 5599 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME%REACT_15452.2 Peptide hormone biosynthesis 1081 3626 3625 3624 3623 94027 93659 2488 1082 94115 5122 5443 3972 114335 83729 7252 KETONE BODY CATABOLISM%REACTOME%REACT_59.4 Ketone body catabolism 38 622 5019 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_118568.2 Pre-NOTCH Transcription and Translation 595 57690 2033 7157 1869 3725 2648 27161 55534 192669 1871 3516 23112 4343 4853 1387 4854 4855 192670 9794 7029 84441 26523 4851 27327 22938 8850 10046 7027 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_6821.2 SCF-beta-TrCP mediated degradation of Emi1 5711 5710 5714 5713 5719 8945 991 23198 6500 5715 5716 5701 7311 5696 5687 5695 5700 5694 5717 5718 5688 5689 8454 26271 51343 5720 7316 10213 5698 5699 143471 5721 6233 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 5684 5683 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME%REACT_18368.4 IRE1alpha activates chaperones 9114 100137049 2931 2137 10106 10525 9820 55033 8681 4189 30827 55062 9570 7466 445329 101928061 2081 55738 7094 3068 6464 1639 1200 101929857 3309 22872 64061 51726 56005 9797 1663 5611 2673 118 11015 7709 4000 58477 27230 6745 10954 116138 10897 10130 5526 9695 10113 6818 37 84447 6734 VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%REACT_11117.1 Vitamin B1 (thiamin) metabolism 27010 10560 80704 79178 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_169165.2 SMAD2 3 MH2 Domain Mutants in Cancer 1030 1875 1874 3065 1025 1024 7048 56288 7046 60436 5045 7040 54778 9040 56937 7311 100527943 11171 142 904 51377 57154 23645 905 64750 7029 2280 4088 7316 4089 9110 9958 5590 7027 57530 5499 6233 4087 25805 23327 4609 50855 387 4221 10273 7050 6667 51592 6497 50848 5054 6498 892 4092 7323 3726 7321 5500 867 5501 7314 9612 9611 25937 8239 5933 4738 101929368 23370 5494 7514 LDL ENDOCYTOSIS%REACTOME%REACT_6934.3 LDL endocytosis 4018 1071 338 26119 319 3949 INHIBITION OF TSC COMPLEX FORMATION BY PKB%REACTOME%REACT_6743.2 Inhibition of TSC complex formation by PKB 7249 7248 208 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_118764.3 ZBP1(DAI) mediated induction of type I IFNs 148022 11035 3146 4615 351 147945 8517 6288 81030 340061 8737 3661 6285 29110 4791 7098 177 5970 4792 23220 1660 4793 4790 1147 6283 3551 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME%REACT_607.3 Activation of caspases through apoptosome-mediated cleavage 840 836 317 54205 842 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_9483.4 FGFR1 ligand binding and activation 2247 2246 2249 2255 26281 27006 2251 2254 2248 8074 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_200808.2 PRC2 methylates histones and DNA 8335 8334 653604 8337 8331 22823 255626 3720 128312 8358 333932 8352 8359 8353 8354 8338 8339 474382 8357 8356 8347 8348 8345 8346 8340 8343 8344 8341 8342 3021 3020 85236 8726 2146 8968 8360 26147 8362 8361 8364 54145 8363 8365 8366 8970 8368 8349 1786 8367 100616282 5928 8351 1788 8350 8355 1789 3013 3012 723790 126961 8294 5252 5931 554313 121504 121536 3015 3014 8370 3018 3017 23512 GLUCOSE TRANSPORT%REACTOME%REACT_212.5 Glucose transport 3099 3098 9631 53371 2542 2646 10762 4927 92579 5903 8086 55746 8021 129401 7175 9883 2538 8480 6515 6513 3101 6517 6514 9688 57818 23225 2645 23165 9972 11097 57122 23279 79902 23511 79023 23636 348995 RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME%REACT_1322.2 Release of apoptotic factors from the mitochondria 56616 54205 NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_13723.2 Neurotransmitter Release Cycle 85390 6616 18 7915 6529 6582 8541 8499 9256 6540 85389 3312 8224 22999 6580 6511 8497 57030 10497 6853 2744 6854 5864 6857 8500 10815 140679 6505 6512 6539 80331 6538 1103 6572 2572 2571 6571 54407 4128 60482 6844 27165 6804 TRANSLESION SYNTHESIS BY DNA POLYMERASES BYPASSING LESION ON DNA TEMPLATE%REACTOME%REACT_2198.4 Translesion synthesis by DNA polymerases bypassing lesion on DNA template 5429 51455 10459 5980 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%REACT_15461.2 Acetylcholine Binding And Downstream Events 1144 55584 1143 1146 1145 1141 1142 1135 1134 1136 1137 1139 1138 89832 8973 POLYAMINES ARE OXIDIZED TO AMINES, ALDEHYDES AND H2O2 BY PAOS%REACTOME%REACT_505.3 Polyamines are oxidized to amines, aldehydes and H2O2 by PAOs 54498 196743 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_120836.2 Synthesis of PIPs at the Golgi membrane 377 7179 100500810 5298 4952 5297 285540 375 5289 5286 56623 5288 30849 55697 55300 93492 200576 9896 22908 55361 INTEGRATION OF PROVIRUS%REACTOME%REACT_6918.4 Integration of provirus 5478 3981 7520 2547 3159 101060363 11168 7518 8815 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%REACT_1763.2 Homologous DNA pairing and strand exchange 83990 5893 675 6119 6118 6117 5888 OPSINS%REACTOME%REACT_18426.1 Opsins 23596 5956 101060233 611 2652 6010 728458 5995 221391 94233 10692 COENZYME A BIOSYNTHESIS%REACTOME%REACT_11218.1 Coenzyme A biosynthesis 53354 8034 80347 79717 79646 55229 80025 60490 NUCLEOTIDE METABOLISM%REACTOME%REACT_1698.12 Nucleotide metabolism 4907 64902 6241 353 6240 5198 100500832 56953 51733 203 9615 204 122622 84618 51727 654364 2618 56474 7084 7083 3615 3614 22978 100130460 2766 2876 26289 132 471 1633 1635 100 3704 83549 8833 10606 100526794 790 847 93034 161823 7296 271 7372 7298 272 7295 4860 7371 978 270 7378 3251 1890 1841 50484 11164 2745 1716 1723 151531 51292 131870 1503 158 159 7498 4830 4831 2987 1806 30833 4833 1807 5471 55270 SIGNALING BY SCF-KIT%REACTOME%REACT_111040.3 Signaling by SCF-KIT 6199 9402 3815 2932 23035 572 5604 5605 2064 2887 1950 7525 2242 1026 3265 5879 6777 145957 2931 4067 1027 8503 1956 2309 5156 8660 7409 9846 2069 26523 5155 7249 983 2475 1839 8651 3932 23239 842 1147 50852 5894 5578 253260 7297 1385 940 3084 685 942 7006 941 3845 84335 64223 4893 26281 101060747 3717 10818 4193 9542 930 5170 5159 23112 57761 10718 5595 2247 2246 2249 2255 8823 27006 2251 2252 867 2254 2248 8817 8074 5594 10019 4318 10603 10076 9306 10750 2549 5291 5293 27161 3569 3667 2534 5728 3570 117145 79109 1111 5290 4343 6772 6774 5781 5777 3164 152831 2264 9965 57690 7529 5296 192669 3716 6776 6654 5295 10000 192670 207 208 2308 27327 1215 2886 2241 G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME%REACT_19145.1 G beta:gamma signalling through PLC beta 2785 2786 51764 2783 2784 2787 59345 2782 5330 2788 94235 2791 5331 55970 54331 2793 10681 2792 23236 2790 RNF MUTANTS SHOW ENHANCED WNT SIGNALING AND PROLIFERATION%REACTOME%REACT_228188.1 RNF mutants show enhanced WNT signaling and proliferation 8335 8334 54894 653604 3065 8337 8331 255626 123169 2535 1857 8358 333932 1856 8352 8359 8353 8354 8338 8339 474382 1855 8357 8356 8347 80351 8348 8345 8346 8340 11197 6259 9101 8343 8344 8341 8342 3021 4609 4040 3020 85236 56998 8968 8360 8362 9736 8361 4221 8364 54145 283149 8363 8295 8365 8366 5519 8970 8368 5518 8349 83999 8367 5515 8085 100616282 5516 8351 8350 4041 8355 5529 3013 5528 3012 5527 5525 8452 723790 126961 5526 8294 554313 121504 3015 3014 84870 8370 3018 3017 8313 55366 59352 340419 7483 607 128312 8323 8325 8321 8322 59349 7015 26108 22943 440193 8549 27123 10524 27121 6422 5534 7534 6423 1387 5530 5532 9070 8290 89780 1455 7514 5711 5710 5714 857 5713 8607 1452 5719 8945 2932 7089 23198 139285 7088 5715 5716 1499 5701 7311 5696 5687 5695 5700 5694 6932 6934 5717 5718 8395 5688 5689 8312 64750 79577 5720 7316 10213 324 5698 83439 9978 5699 7090 7091 10023 143471 5721 6233 801 805 808 101929777 343637 6597 1487 23401 10197 50964 5707 5929 5706 5709 5708 5690 7471 5705 5691 5704 7314 5692 5693 5702 7473 7474 7478 122706 7479 5686 5685 5682 9861 9491 51176 5684 5683 23072 84133 331 284654 25776 57680 8658 90780 51339 2033 1454 4775 1459 1457 81847 4773 207 4772 208 1460 7855 79412 54361 80319 TRAFFICKING OF AMPA RECEPTORS%REACTOME%REACT_18307.1 Trafficking of AMPA receptors 160 80852 27092 816 5582 817 818 101929306 23426 815 2892 2891 4193 2893 9495 10369 10368 5579 1742 4646 2890 9463 2036 101930324 1739 4905 59283 5578 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME%REACT_1974.2 RNA Polymerase I Promoter Clearance 3066 728340 8335 8334 1022 653604 3065 8337 8331 902 30834 255626 8358 333932 8352 8359 9013 8353 8354 9014 8338 8339 677805 9533 474382 4331 8357 8356 8347 57459 8348 8345 7270 8346 6908 8340 57504 79101 10849 54700 8343 8344 8341 8342 3021 64425 3020 692063 85236 2968 2967 8968 8360 8362 8361 100302240 84172 8364 54145 8363 8365 8366 8970 8368 8349 8367 100616282 5928 8351 654320 9112 8350 9015 25885 8355 5595 3013 3012 51082 692072 54815 5440 677822 8932 723790 5441 126961 8294 7343 677792 2068 2074 2071 5931 8850 554313 121504 9219 3015 3014 8370 3018 2965 2966 3017 53615 1108 1107 2648 10919 5437 5434 5435 128312 221830 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_172715.3 Detoxification of Reactive Oxygen Species 847 5034 7296 7295 9588 100129518 10935 2882 54205 2878 25828 10587 7001 493869 30001 5052 475 343 2877 6649 6648 2876 6647 9973 538 2950 XAV939 INHIBITS TANKYRASE, STABILIZING AXIN%REACTOME%REACT_228279.1 XAV939 inhibits tankyrase, stabilizing AXIN 8335 8334 54894 653604 3065 8337 8331 255626 123169 2535 1857 8358 333932 1856 8352 8359 8353 8354 8338 8339 474382 1855 8357 8356 8347 80351 8348 8345 8346 8340 11197 6259 9101 8343 8344 8341 8342 3021 4609 4040 3020 85236 56998 8968 8360 8362 9736 8361 4221 8364 54145 283149 8363 8295 8365 8366 5519 8970 8368 5518 8349 83999 8367 5515 8085 100616282 5516 8351 8350 4041 8355 5529 3013 5528 3012 5527 5525 8452 723790 126961 5526 8294 554313 121504 3015 3014 84870 8370 3018 3017 8313 55366 59352 340419 7483 607 128312 8323 8325 8321 8322 59349 7015 26108 22943 440193 8549 27123 10524 27121 6422 5534 7534 6423 1387 5530 5532 9070 8290 89780 1455 7514 5711 5710 5714 857 5713 8607 1452 5719 8945 2932 7089 23198 139285 7088 5715 5716 1499 5701 7311 5696 5687 5695 5700 5694 6932 6934 5717 5718 8395 5688 5689 8312 64750 79577 5720 7316 10213 324 5698 83439 9978 5699 7090 7091 10023 143471 5721 6233 801 805 808 101929777 343637 6597 1487 23401 10197 50964 5707 5929 5706 5709 5708 5690 7471 5705 5691 5704 7314 5692 5693 5702 7473 7474 7478 122706 7479 5686 5685 5682 9861 9491 51176 5684 5683 23072 84133 331 284654 25776 57680 8658 90780 51339 2033 1454 4775 1459 1457 81847 4773 207 4772 208 1460 7855 79412 54361 80319 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_120989.2 Chondroitin sulfate biosynthesis 50515 166012 10675 56548 79586 1464 9469 1462 55790 51363 55454 63827 22856 55501 337876 1463 633 54480 1634 POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME%REACT_118699.3 Post-transcriptional silencing by small RNAs 27327 192670 27161 57690 192669 26523 23112 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_9452.2 FGFR4 ligand binding and activation 2264 2247 9965 2246 2249 8823 26281 2251 2254 8817 8074 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_121384.2 Acyl chain remodelling of PS 154141 100652777 11145 255189 64600 123745 30814 26279 81579 283748 5320 5322 5319 8681 5321 254531 10162 100137049 8399 HUR STABILIZES MRNA%REACTOME%REACT_25218.2 HuR stabilizes mRNA 8125 5580 8741 1994 6418 8021 5578 7514 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%REACT_16907.2 Association of TriC CCT with target proteins during biosynthesis 6950 83752 10575 10694 8877 22948 100302138 101927137 11328 10576 10564 100507577 26792 10574 6468 10528 908 692213 677812 26272 7203 63971 10517 692201 26985 55294 100996906 54461 26224 22803 6499 26190 8237 26270 26234 84261 BASE EXCISION REPAIR%REACTOME%REACT_1104.2 Base Excision Repair 5111 2237 6996 57804 4913 4968 5425 8930 10309 4350 5424 7515 3978 23583 3980 10714 5423 328 4595 PURINE METABOLISM%REACTOME%REACT_522.6 Purine metabolism 4907 847 93034 353 161823 5198 271 272 4860 270 3251 9615 122622 84618 2618 1716 51292 3615 3614 100130460 2766 22978 2876 158 159 7498 132 471 1633 100 30833 5471 8833 10606 100526794 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME%REACT_23974.3 Incretin synthesis, secretion, and inactivation 2864 51764 139760 1045 338557 2784 60559 1803 2922 3952 3670 2641 5080 346562 28972 5122 2626 23478 2695 9789 90701 6934 PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME%REACT_2055.4 Processing of DNA double-strand break ends 6119 6118 6117 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME%REACT_160.1 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 1666 33 34 3032 3030 1632 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_150314.2 Mitotic Metaphase and Anaphase 5711 6232 5710 5714 5713 5719 23198 5715 5716 5701 7311 5696 5687 4001 23047 5695 5700 55746 5885 5694 5717 5718 5688 9126 5689 2491 57082 246184 23244 5720 7316 10213 5698 5699 143471 5721 6233 5905 5519 5518 5515 5516 10726 5347 5529 5528 5527 10197 5707 5525 5706 5709 5708 5690 5705 5691 7321 5704 23122 5526 7314 5692 5693 23332 5702 122706 5686 5685 5682 9861 9491 8815 8243 5684 5683 57405 996 1058 80152 83540 7324 9184 991 699 23592 1062 1063 1060 151648 9183 9232 348235 81565 25909 55166 3796 730268 5903 57551 8379 51433 79019 55920 11130 100527963 5048 22919 23421 11065 26271 55143 55839 91687 23141 64105 81930 79172 29882 6249 9212 7443 8697 80776 29945 4085 84643 3619 9793 51529 25936 401541 11243 100526739 147841 5520 23279 9700 151246 79902 220134 6396 701 10393 348995 378708 23063 113130 51434 55055 54821 54820 11004 9735 79980 221496 79003 2010 64682 5501 10735 79682 64946 54908 10274 10403 332 8881 57122 79023 7514 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_169280.2 Defective AMN causes hereditary megaloblastic anemia 1 55191 4552 1719 4548 32 4594 31 23475 9446 5743 5646 8029 5645 55229 5644 25974 55312 81034 316 53354 55163 8034 6947 10560 55034 81693 9962 3141 9963 56922 60496 60490 27010 8566 166785 23057 5095 326625 5096 101929880 440387 101928493 6948 6470 1504 51293 349565 80025 64087 4338 27249 4524 54 6573 51248 113278 80347 101928717 2694 5091 4522 119391 113235 27304 65220 80704 79178 200895 6515 6513 93100 5167 55788 8884 80308 5740 1528 79717 4363 1582 2194 1727 10135 686 64802 10243 79646 MISSPLICED GSK3BETA MUTANTS STABILIZE BETA-CATENIN%REACTOME%REACT_228314.1 misspliced GSK3beta mutants stabilize beta-catenin 5711 5710 5714 5713 1452 5719 3065 8945 2932 7089 23198 139285 7088 6500 5715 5716 1499 5701 7311 5696 5687 5695 5700 166 5694 6932 6934 5717 5718 5688 5689 8454 8312 5720 7316 10213 324 5698 83439 9978 5699 7090 7091 10023 143471 5721 6233 5519 5518 5515 5516 5529 1487 5528 1488 5527 23401 10197 5707 5525 5706 5709 5708 5690 5705 5691 5704 5526 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 51176 5684 5683 UNWINDING OF DNA%REACTOME%REACT_6776.3 Unwinding of DNA 4171 51659 84515 4176 4173 8318 4174 4172 4175 84296 9837 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_120727.4 Downregulation of TGF-beta receptor signaling 25805 23327 7048 7046 7040 10273 56937 7311 11171 4092 51377 57154 23645 64750 5500 5501 7314 4088 7316 9110 9958 5499 7514 6233 4087 REGULATION OF GAP JUNCTION ACTIVITY%REACTOME%REACT_11034.2 Regulation of gap junction activity 7082 2697 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_13443.1 Regulated proteolysis of p75NTR 5664 55851 6868 4804 83464 51107 5970 4790 23385 7189 MPS I - HURLER SYNDROME%REACTOME%REACT_147857.2 MPS I - Hurler syndrome 23563 10331 2239 3373 79586 9469 3339 126792 9653 3073 3340 3074 6383 11285 10678 9435 3038 9394 10675 3037 3036 2720 283464 8372 100616124 2719 727936 4958 9957 11041 9956 9955 633 3425 1634 3423 11046 79369 27087 9348 347734 11081 411 176 63827 6382 643853 6385 8509 8702 26035 8704 8703 9331 10855 9334 4969 10861 2262 10057 29940 2990 64579 2817 2132 2131 60495 960 55454 10082 6482 6483 6487 6484 1836 6548 135152 56548 266722 10402 51363 22856 221914 222537 93010 10090 10894 55576 2799 6448 8692 337876 26229 90161 64711 166012 11261 375790 3161 113189 5549 9951 9953 9672 1463 4669 2331 51000 8534 50515 4060 1464 9060 1462 55790 2683 92126 55501 4166 9061 79411 54480 ASSEMBLY OF VIRAL COMPONENTS AT THE BUDDING SITE%REACTOME%REACT_6277.4 Assembly of Viral Components at the Budding Site 811 821 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_11153.7 Biotin transport and metabolism 64087 5095 32 51248 31 5096 8884 686 3141 5091 56922 PAUSING AND RECOVERY OF HIV ELONGATION%REACTOME%REACT_6244.6 Pausing and recovery of HIV elongation 1025 5438 100126332 5439 5436 5437 5434 5435 8178 5431 5433 904 5430 905 5432 6749 2962 7469 5440 2963 100302242 6829 25920 5441 11198 6827 7936 9150 6921 6924 6923 6917 51497 GLYOXYLATE METABOLISM%REACTOME%REACT_16925.1 Glyoxylate metabolism 1610 64902 189 54363 9380 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME%REACT_12056.5 NGF signalling via TRKA from the plasma membrane 5603 53358 25759 1398 8503 26052 7409 6300 3708 3709 1432 5519 5518 5515 5516 1211 23112 5153 5595 5600 5528 6195 6197 6196 4914 2889 1399 160 163 161 4803 2549 5291 5293 3569 3667 2534 5728 3570 117145 79109 5290 4343 9261 6774 5781 1173 1175 5136 3164 6456 3710 6464 7529 5900 5898 5899 107 108 109 4915 135 117 116 1759 27327 6199 3815 2932 5581 23035 5582 572 5604 5605 2064 1950 1026 1785 3265 145957 2931 1027 1956 2309 5607 5156 8660 1845 112 6014 1848 5335 115 10126 57498 114 1849 6016 466 111 5137 113 1846 2069 26523 196883 5155 814 7249 5580 7867 983 2475 5598 1839 3932 23239 842 1147 50852 5894 5578 801 253260 805 156 808 7297 1385 940 3084 685 942 941 3845 84335 64223 4893 101060747 26281 3717 10818 4193 9542 930 5170 5159 57761 10718 2247 2246 2249 2255 8823 673 27006 2251 2252 2254 2248 8817 8074 5594 27161 5577 5906 5576 5573 5568 5567 5566 5575 152831 2264 9252 9965 387 57690 2002 4205 101927462 4208 5296 192669 3716 6654 5295 10000 192670 207 208 2308 S45 MUTANTS OF BETA-CATENIN AREN'T PHOSPHORYLATED%REACTOME%REACT_228137.1 S45 mutants of beta-catenin aren't phosphorylated 5711 5710 5714 5713 1452 5719 3065 8945 2932 7089 23198 139285 7088 6500 5715 5716 1499 5701 7311 5696 5687 5695 5700 166 5694 6932 6934 5717 5718 5688 5689 8454 8312 5720 7316 10213 324 5698 83439 9978 5699 7090 7091 10023 143471 5721 6233 5519 5518 5515 5516 5529 1487 5528 1488 5527 23401 10197 5707 5525 5706 5709 5708 5690 5705 5691 5704 5526 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 51176 5684 5683 RNA POLYMERASE II HIV PROMOTER ESCAPE%REACTOME%REACT_6253.4 RNA Polymerase II HIV Promoter Escape 728340 6877 51616 1022 2968 6881 2967 6878 5438 6875 5439 5436 6880 902 6883 6884 6882 5437 5434 5435 2957 5431 2959 2958 5433 5430 5432 6872 6874 2960 2961 2962 2963 5440 5441 6873 138474 4331 2068 102157402 2071 83860 6908 2965 2966 GABA A (RHO) RECEPTOR ACTIVATION%REACTOME%REACT_25168.1 GABA A (rho) receptor activation 2569 2570 200959 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_160176.3 Cytosolic iron-sulfur cluster assembly 9391 83990 22 57019 4682 27158 64210 64428 2068 5424 51750 51647 10101 CRMPS IN SEMA3A SIGNALING%REACTOME%REACT_19199.1 CRMPs in Sema3A signaling 2932 55558 8829 1809 10570 10371 1808 91584 1400 2242 5362 1020 5361 56896 2534 8851 TRANSPORT OF HA TRIMER, NA TETRAMER AND M2 TETRAMER FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME%REACT_6215.4 Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME%REACT_18422.1 Trafficking of GluR2-containing AMPA receptors 160 80852 5579 5582 2890 23426 2892 2891 9463 2893 101930324 5578 4905 BINDING OF TCF LEF:CTNNB1 TO TARGET GENE PROMOTERS%REACTOME%REACT_200799.2 binding of TCF LEF:CTNNB1 to target gene promoters 4609 8313 83439 6932 6934 51176 1499 HOST INTERACTIONS OF HIV FACTORS%REACTOME%REACT_6288.4 Host Interactions of HIV factors 5711 5710 5714 5713 5719 8945 23198 5062 6500 5715 5716 5701 7311 5696 5687 5695 5700 55746 5694 1794 5879 5717 9844 5718 11168 5688 5689 3055 100500810 5720 7316 10213 5698 1104 9978 5699 3932 101060363 143471 5721 6233 5478 940 5902 5905 8907 8905 8021 9883 7175 3105 10197 5707 5706 5709 5708 8065 5690 5705 10053 5691 5704 7314 5692 23225 5693 5702 122706 11097 5686 5685 5682 9861 23511 9491 8815 5684 23636 5683 160 1025 164 163 162 161 10762 926 567 920 5903 2534 904 8480 292 291 100996919 1174 1173 51606 5901 293 1175 375 23165 23279 79902 55690 348995 9631 53371 3159 130340 4927 101927462 8086 129401 4869 3836 9688 3837 6921 9972 6923 57122 79023 7514 HISTAMINE RECEPTORS%REACTOME%REACT_16903.1 Histamine receptors 59340 3274 11255 3269 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_111083.2 The citric acid (TCA) cycle and respiratory electron transport 3945 116228 1537 2271 79944 4191 101929716 4731 4728 3419 3418 4724 4729 9167 84987 3421 9997 6256 29796 51241 6390 9551 6392 6391 9123 23539 6389 7384 6566 682 8801 3420 1327 8802 8803 23530 7352 7350 1329 374291 7351 4967 7381 7388 1353 51079 7385 7386 1337 8050 25874 1350 498 55967 1351 1340 1349 1345 4696 5467 4695 27109 57546 4694 1381 1382 10128 54205 285521 137872 6341 4535 539 4539 100616403 4537 4536 4698 4697 10632 50 27089 100532726 4711 4722 522 3939 4514 521 4726 4723 4508 4720 4725 10476 2110 4509 51660 2108 2109 4702 4701 728294 55066 4700 4716 1431 513 4718 54539 4717 4712 518 4719 517 4713 516 515 4714 4540 514 4538 4710 4715 4541 5162 1743 5163 506 5160 509 6834 5166 4709 5164 54704 5165 4707 4708 51204 1737 1738 4706 4704 9377 4705 440567 126328 4519 10975 4513 4512 SHC-MEDIATED CASCADE%REACTOME%REACT_21374.2 SHC-mediated cascade 152831 2247 2264 9965 2246 2249 2255 8823 27006 2251 2252 2254 2248 8817 8074 3845 4893 26281 3265 6654 STRIATED MUSCLE CONTRACTION%REACTOME%REACT_16969.2 Striated Muscle Contraction 88 89 4607 7171 7170 4606 1674 4604 4626 4624 7134 7136 7431 4621 7137 7111 7135 7138 7273 1756 7168 4635 4632 7169 7139 4633 7125 4634 7140 4703 8557 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME%REACT_15480.3 ABC-family proteins mediated transport 11194 22 10349 215 21 5825 10347 64137 23460 5243 9619 23456 10351 101930322 89845 1080 8504 10058 225 10060 368 10257 26154 5824 20 24 85320 1244 10057 335 6833 4363 10350 340273 8714 64241 64240 AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%REACT_795.3 Amplification of signal from the kinetochores 8379 4085 INHIBITION OF PKR%REACTOME%REACT_6350.4 Inhibition of PKR 5610 CGMP EFFECTS%REACTOME%REACT_23767.1 cGMP effects 5593 10242 8654 3708 5140 5136 5138 5139 10335 27345 27094 3779 5153 3778 5152 10846 50940 INHIBITION OF HSL%REACTOME%REACT_1123.1 Inhibition of HSL 208 5140 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME%REACT_6769.1 Activation of ATR in response to replication stress 1017 84515 4173 23594 4172 8318 1111 995 144715 55388 8317 5884 10926 5883 63967 5982 3364 5983 5001 4999 5000 6119 4998 6118 6117 84126 545 4171 4176 4174 4175 5985 5984 23595 990 993 5810 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_19343.1 Facilitative Na+-independent glucose transporters 6515 11182 154091 56606 81031 29988 6517 6514 6518 66035 155184 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_697.4 Activation of BH3-only proteins 7531 637 100422899 100422832 572 90427 7533 7532 7529 7157 1869 5534 5366 7534 8655 10000 596 207 208 10018 27113 5533 140735 2810 10971 7027 5599 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_18273.4 XBP1(S) activates chaperone genes 9114 100137049 2931 2137 10106 10525 9820 55033 8681 4189 30827 55062 9570 7466 445329 101928061 55738 7094 6464 3068 1639 1200 101929857 22872 64061 51726 56005 9797 1663 5611 2673 118 11015 7709 4000 58477 27230 6745 10954 116138 10897 10130 5526 9695 10113 6818 37 84447 6734 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_200775.2 HSF1-dependent transactivation 1387 3303 3305 85390 3281 3337 2288 10728 3297 3320 816 817 818 2033 815 84335 64223 2475 3312 85389 3326 3304 3306 57521 DNA REPAIR%REACTOME%REACT_216.2 DNA Repair 728340 1022 5438 5439 5436 902 7311 4361 3978 4683 5111 5982 5981 5983 2237 5591 4331 7316 5426 5425 5424 121642 221120 5985 5984 6233 83990 91442 2188 4255 2189 4436 2178 2968 2187 2967 4437 7507 7508 56949 55120 7398 5887 27033 2067 1161 79728 55775 7158 5395 5440 5441 7314 2068 2074 2071 4350 23583 3014 2965 2966 2547 4913 4968 8930 5429 10309 51455 5437 7515 10459 3980 5434 5423 5435 5980 328 4595 5893 6996 6119 6118 6117 5888 1643 2175 57697 2073 1642 6917 2177 2176 29089 9656 2956 2072 55215 9156 80233 5427 7520 7518 57804 10714 5431 5433 5430 5432 3981 10111 545 672 4292 472 675 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_200819.2 Cellular response to heat stress 1915 3305 85390 3281 3337 2288 7531 3297 2932 816 817 818 2033 815 84335 7415 57805 64223 85389 3312 3326 3306 91582 57521 9261 5595 1387 3303 10728 3320 10013 6119 6118 6117 23411 545 2475 472 5594 3304 SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME%REACT_22346.1 Synthesis of dolichyl-phosphate-glucose 29880 INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS%REACTOME%REACT_6757.3 Interactions of Vpr with host cellular proteins 9631 53371 3159 10762 4927 5903 55746 8021 8086 129401 7175 9883 11168 8480 292 291 3836 9688 293 23225 9972 23165 11097 57122 23279 79902 23511 8815 79023 348995 23636 RNA POLYMERASE II TRANSCRIPTION%REACTOME%REACT_1366.2 RNA Polymerase II Transcription 728340 6428 6429 1022 5438 6430 5439 5436 10250 902 6628 6432 6431 6634 6635 6636 6872 53981 6874 6637 7307 8683 6873 11198 138474 4331 6827 9785 6908 100126351 100302196 6877 84967 6881 2968 6878 2967 51692 6875 8731 6880 6883 6884 8732 6882 2957 2959 2958 55110 8106 22916 2960 2961 6749 2962 5440 2963 134353 100302242 5441 2068 102157402 2071 51362 6427 6426 51497 51585 2965 2966 9939 1025 5437 5434 5435 904 905 4116 7469 7884 11338 1477 79869 6917 25888 1478 10978 1479 51616 100126332 693221 10189 8178 5431 5433 5430 11051 5432 10921 9295 6829 25920 283459 4686 7936 9150 10914 6921 6924 83860 6923 29894 65109 SMAC-MEDIATED APOPTOTIC RESPONSE%REACTOME%REACT_666.1 SMAC-mediated apoptotic response 840 56616 836 331 842 DSCAM INTERACTIONS%REACTOME%REACT_25299.1 DSCAM interactions 5600 5058 5603 1630 57453 1826 5879 5599 9423 6300 1432 ERK1 ACTIVATION%REACTOME%REACT_1391.4 ERK1 activation 983 5604 5595 PDE3B SIGNALLING%REACTOME%REACT_1451.1 PDE3B signalling 208 5140 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_150352.2 Synthesis of IP2, IP, and Ins in the cytosol 3631 3613 8821 3612 4952 51477 8867 3633 3632 3628 27124 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_18283.4 G alpha (q) signalling events 10235 5581 3269 9630 553 5588 5020 552 8503 7204 2864 94235 5580 11343 2776 23236 156 51764 2791 2641 2642 3708 183 3709 2767 2769 3062 57113 10681 10125 7225 7222 160851 5028 5583 9002 846 1241 57121 3814 2922 1133 431704 3358 84109 27334 3357 2915 2846 139189 2911 60675 84432 5029 84634 10161 115557 9170 2796 128674 185 3356 2828 2829 10287 10886 10316 624 10800 2798 5290 2797 94233 23620 10887 2867 8997 6863 2865 8477 6915 347148 3061 59345 2869 6288 257313 23566 2693 5724 5997 2862 3060 57105 387129 29933 2520 3827 146 147 5031 148 5032 2925 551 3710 2840 64106 594857 1609 1607 1608 6846 1606 8620 221955 680 2785 8527 2786 2150 2783 886 885 8526 2784 8525 2787 5330 6865 2788 6866 6869 5332 747 5331 6870 2147 2149 5731 5737 55970 351 5296 2358 54331 301 2793 2792 2790 5295 6375 9162 56413 623 10874 129521 2837 5021 1128 2782 7201 7200 1910 1131 56923 64407 1908 2847 10911 1906 5367 1907 1909 222545 8111 1902 4295 4828 4829 4922 114814 887 84539 2151 4923 TRANSCRIPTION OF THE HIV GENOME%REACTOME%REACT_6233.4 Transcription of the HIV genome 728340 1022 5438 1025 5439 5436 902 5437 5434 5435 904 905 6872 6874 7469 11198 6873 138474 4331 6827 6917 6908 6877 51616 2968 6881 2967 6878 100126332 6875 8731 6880 6883 6884 8732 6882 8178 2957 5431 2959 2958 5433 5430 5432 22916 2960 2961 2962 6749 2963 5440 100302242 6829 5441 25920 4686 7936 2068 102157402 9150 6921 2071 6924 83860 6923 2965 51497 2966 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_121006.2 Acyl chain remodeling of CL 5321 6901 3032 3030 253558 8398 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_111056.1 Cross-presentation of soluble exogenous antigens (endosomes) 5711 5710 5714 5713 5719 23198 5715 5716 5701 5696 5687 5695 5700 5694 5717 5718 5688 5689 5720 10213 5698 5699 143471 5721 9902 4360 50489 100132417 101928757 10197 5707 5706 5709 5708 5690 5705 5691 5704 5692 5693 5702 2210 122706 2209 5686 5685 5682 9861 9491 5684 5683 CLEARANCE OF SERATONIN%REACTOME%REACT_15391.1 Clearance of seratonin 217 4128 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME%REACT_338.2 Transport of Mature mRNAs Derived from Intronless Transcripts 100302196 9631 51692 53371 10762 4927 10189 5903 55746 8021 8086 129401 7175 9883 8480 53981 22916 1977 7884 9688 4686 23225 23165 9972 11097 57122 23279 29894 10482 79902 23511 100126351 79023 348995 23636 ABACAVIR METABOLISM%REACTOME%REACT_121388.2 Abacavir metabolism 161823 2987 124 22978 5105 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME%REACT_17017.1 Beta-oxidation of pristanoyl-CoA 3295 54677 1384 10005 8310 8309 23600 DIMERIZATION OF PROCASPASE-8%REACTOME%REACT_832.4 Dimerization of procaspase-8 8717 841 8743 355 7186 8772 356 8737 8795 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_25282.1 Inhibition of adenylate cyclase pathway 112 115 114 111 113 2774 346562 196883 2773 107 108 109 2771 2770 BILE ACID AND BILE SALT METABOLISM%REACTOME%REACT_11040.2 Bile acid and bile salt metabolism 3295 10858 80270 8648 10005 11001 8309 23600 1581 101930400 8644 1109 1593 1646 5740 2172 6555 10599 1582 9023 9420 6718 570 213 345274 8647 28234 1645 8714 9971 6554 6256 51302 10499 10998 6579 NGF-INDEPENDANT TRKA ACTIVATION%REACTOME%REACT_11046.2 NGF-independant TRKA activation 4914 4915 135 117 116 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME%REACT_1036.2 RNA Polymerase III Transcription Initiation From Type 2 Promoter 55814 27297 9330 5437 84265 5434 5435 101060521 661 51082 55718 9328 5440 9329 171568 5441 9533 10623 10621 51728 11128 10622 2972 55703 6908 2976 2975 HIGHLY SODIUM PERMEABLE ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME%REACT_22223.1 Highly sodium permeable acetylcholine nicotinic receptors 1144 1143 1136 1146 1145 1141 1137 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_160133.1 Signaling by NOTCH1 HD Domain Mutants in Cancer 3066 3714 6868 3065 3280 6907 54492 1024 7089 408 409 7088 23462 6500 3091 7311 2648 8650 83464 113878 10014 51107 1272 8454 9794 26508 10013 102 84441 101928143 23493 4851 8788 5664 7316 142678 22938 9759 9978 10046 7091 54567 57534 83737 6233 51564 55851 79885 4609 9148 2033 55869 55534 182 892 8841 101930388 3516 28514 388585 83933 9734 1387 7314 9612 9611 92737 1840 8850 79718 23220 23385 PROTON OLIGONUCLEOTIDE COTRANSPORTERS%REACTOME%REACT_19328.1 Proton oligonucleotide cotransporters 51296 121260 6564 6565 ACTIVATION OF CAMK IV%REACTOME%REACT_20652.1 Activation of CaMK IV 801 805 808 814 TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME%REACT_346.6 Transcriptional activation of cell cycle inhibitor p21 7157 1026 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_118700.3 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 28916 28442 28454 28912 4690 5293 6850 2534 4067 5335 7409 5336 28908 28299 695 30011 3710 3538 973 801 974 805 640 3539 808 27071 6725 6786 100423062 118788 7220 3708 3507 3542 3709 29760 3495 868 3514 28776 84876 930 28876 6654 5295 28874 867 28896 28834 440786 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_804.4 Base-Excision Repair, AP Site Formation 4913 4968 8930 10309 4350 23583 6996 4595 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME%REACT_207.3 Removal of licensing factors from origins 5711 1017 5710 51053 5714 5713 5719 23198 5925 5715 5716 5701 7311 5696 5687 1026 5695 5700 5694 5717 5718 5688 5689 1027 51343 55388 8900 5001 4999 5000 4998 4171 5720 7316 10213 4176 5698 890 4174 4175 5699 23595 143471 990 5721 6233 84515 4173 23594 4172 81620 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 5684 5683 MINUS-STRAND DNA SYNTHESIS%REACTOME%REACT_9055.2 Minus-strand DNA synthesis 5478 101060363 ASSEMBLY OF THE RAD50-MRE11-NBS1 COMPLEX AT DNA DOUBLE-STRAND BREAKS%REACTOME%REACT_486.3 Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks 4361 4683 3014 10111 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_115639.1 Sulfur amino acid metabolism 4552 2729 4548 191 55748 1491 55256 4507 51380 58472 7263 875 58478 84245 635 27430 2730 1036 4143 1468 4144 23474 51074 6821 2805 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME%REACT_238.2 Amino acid synthesis and interconversion (transamination) 5723 4942 2746 5831 29968 2875 26227 883 440 2744 2806 27165 2752 2805 DELETIONS IN THE AXIN GENES IN HEPATOCELLULAR CARCINOMA RESULT IN ELEVATED WNT SIGNALING%REACTOME%REACT_228112.1 deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling 5711 5710 5714 5713 1452 5719 3065 8945 2932 7089 23198 139285 7088 6500 5715 5716 1499 5701 7311 5696 5687 5695 5700 166 5694 6932 6934 5717 5718 5688 5689 8454 8312 5720 7316 10213 324 5698 83439 9978 5699 7090 7091 10023 143471 5721 6233 5519 5518 5515 5516 5529 1487 5528 1488 5527 23401 10197 5707 5525 5706 5709 5708 5690 5705 5691 5704 5526 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 51176 5684 5683 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_6820.1 APC C:Cdc20 mediated degradation of Cyclin B 51434 11065 996 7324 891 991 29882 7321 64682 246184 8697 7314 29945 8881 7316 7311 51529 983 730268 51433 10393 6233 ADHERENS JUNCTIONS INTERACTIONS%REACTOME%REACT_19195.1 Adherens junctions interactions 1001 1012 1002 1004 1013 1005 1016 1007 1008 5817 5819 1006 3728 1009 1015 57863 1010 5818 999 23705 64403 1495 1000 25945 1500 253559 1003 81607 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME%REACT_1786.3 Phenylalanine and tyrosine catabolism 6898 5092 2954 5860 883 2184 3242 3081 5053 101929036 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_147825.2 MPS IV - Morquio syndrome A 23563 10331 2239 3373 79586 9469 3339 126792 9653 3073 3340 3074 6383 11285 10678 9435 3038 9394 10675 3037 3036 2720 283464 8372 100616124 2719 727936 4958 9957 11041 9956 9955 633 3425 1634 3423 11046 79369 27087 9348 347734 11081 411 176 63827 6382 643853 6385 8509 8702 26035 8704 8703 9331 10855 9334 4969 10861 2262 10057 29940 2990 64579 2817 2132 2131 60495 960 55454 10082 6482 6483 6487 6484 1836 6548 135152 56548 266722 10402 51363 22856 221914 222537 93010 10090 10894 55576 2799 6448 8692 337876 26229 90161 64711 166012 11261 375790 3161 113189 5549 9951 9953 9672 1463 4669 2331 51000 8534 50515 4060 1464 9060 1462 55790 2683 92126 55501 4166 9061 79411 54480 PYRIMIDINE BIOSYNTHESIS%REACTOME%REACT_21376.2 Pyrimidine biosynthesis 1723 1635 7298 7372 790 ENTRY OF INFLUENZA VIRION INTO HOST CELL VIA ENDOCYTOSIS%REACTOME%REACT_6147.4 Entry of Influenza Virion into Host Cell via Endocytosis 1211 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_24970.1 Factors involved in megakaryocyte development and platelet production 3066 1017 653604 3065 3043 9927 23468 139818 1020 5889 1794 5879 8358 55669 333932 3797 85440 8352 140628 22920 64145 64147 8353 3833 8354 3832 3835 3831 29127 9371 23186 7465 51317 10938 8357 2626 11127 8356 5890 3665 57572 285643 26153 56992 3661 4602 1795 161882 91768 89953 25970 2625 4778 2623 2624 4097 2627 3021 3020 8968 100616282 3717 10112 8351 8350 9493 8355 25 126961 1062 10019 10603 829 3796 830 81930 5577 5576 84643 5573 5568 5567 5566 3705 5575 1793 2033 7157 3442 3440 3441 1387 7975 23028 23414 64837 3439 55619 11004 3451 3045 3046 81704 3048 3443 998 3047 3444 147700 24137 3452 8165 3448 80005 3449 55604 3445 832 3446 11311 23764 81928 50808 3660 3659 3456 5868 3799 10362 30845 30846 11216 25942 221037 3798 23348 9732 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME%REACT_20653.2 ADP signalling through P2Y purinoceptor 12 2785 2786 51764 2783 2784 2787 59345 2782 2788 94235 2791 346562 64805 2773 55970 54331 2793 10681 2771 2792 2790 2770 POTASSIUM CHANNELS%REACTOME%REACT_75908.1 Potassium Channels 3790 54207 50801 3776 94235 3773 27345 27094 83795 89822 3754 56659 3752 3751 3758 3757 3756 338567 3755 3764 131096 9132 348980 3782 3781 10021 3783 3739 610 3738 3737 9424 3736 27012 3750 9196 51305 3748 10089 57657 8514 9312 23415 3787 3786 23416 3785 3784 3788 170850 56479 93107 3775 3777 3780 10242 3744 3746 81033 3749 3743 7881 26251 3741 3742 90134 169522 27133 3779 3778 2785 2786 2783 3760 3761 2784 2787 2788 3747 3745 100996843 3759 55970 10060 54331 2793 2792 2790 3768 3766 3770 100134444 3763 6833 3765 2782 3772 9568 3762 2550 3767 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_27307.1 Interleukin-6 signaling 3572 9021 7297 6774 5781 3569 3717 3570 867 3716 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME%REACT_120969.2 O2 CO2 exchange in erythrocytes 760 3040 3043 6005 759 358 762 3039 6521 HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME%REACT_163785.2 Hydroxycarboxylic acid-binding receptors 27198 338442 8843 3' -UTR-MEDIATED TRANSLATIONAL REGULATION%REACTOME%REACT_1762.2 3' -UTR-mediated translational regulation 6231 6232 6044 26784 26781 100505503 26780 6043 7311 116936 26778 116938 6228 6229 6227 6235 4736 6230 26771 6234 84546 26809 25873 2197 100124516 3646 8669 94163 26791 26790 6233 8668 101060318 677847 6224 6223 6222 6203 6201 6202 23521 1981 595100 6210 6205 6204 6208 6209 6206 6207 6217 6218 3921 6083 6165 6137 6168 6136 6138 6161 6139 6164 6160 8894 1965 6130 6133 9045 6132 6135 6167 101929876 6134 6169 85388 6143 6144 6141 6142 619567 1964 1968 6147 619568 606500 6146 619565 619499 619562 7458 100302143 100529097 1974 11224 1973 1977 26819 1975 26815 26817 26818 26816 6129 51121 6128 6193 6194 6192 6191 26820 652965 6124 6123 652966 6122 6125 9349 6171 574040 6170 619505 6173 8663 100526842 8661 6176 8662 6175 26811 8666 8667 8665 26814 6189 6188 8664 26795 6187 595097 27335 595099 100996747 100508408 6181 595098 6154 6155 26986 6152 6159 8944 6157 6158 6156 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_11172.2 Vitamin B5 (pantothenate) metabolism 53354 8034 51248 8884 80347 79717 79646 55229 2194 60496 80025 60490 ABH3 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME%REACT_1662.4 ABH3 mediated Reversal of Alkylation Damage 221120 TRANSPORT AND SYNTHESIS OF PAPS%REACTOME%REACT_6840.4 Transport and synthesis of PAPS 10861 347734 9061 9060 1836 51000 100616124 PYRIMIDINE SALVAGE REACTIONS%REACTOME%REACT_655.2 Pyrimidine salvage reactions 1890 7084 151531 7083 100500832 1633 83549 7371 978 7378 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME%REACT_20580.1 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 6251 9459 87 7016 55742 3987 100288695 5829 29780 GLUCONEOGENESIS%REACTOME%REACT_1520.4 Gluconeogenesis 2023 8604 7167 229 226 2027 2026 2597 5223 5224 4191 2203 4190 10165 2821 5230 6576 8402 5106 5105 1468 5568 8789 5567 5566 5207 230 5091 26330 2806 2805 TERMINAL PATHWAY OF COMPLEMENT%REACTOME%REACT_8028.2 Terminal pathway of complement 731 730 727 729 733 735 732 TRANSLESION SYNTHESIS BY POL ETA%REACTOME%REACT_1287.3 Translesion synthesis by Pol eta 5429 ARACHIDONATE PRODUCTION FROM DAG%REACTOME%REACT_19308.1 Arachidonate production from DAG 11343 747 221955 CIRCADIAN CLOCK%REACTOME%REACT_24941.3 Circadian Clock 5187 5465 1628 8553 79365 8864 8945 6907 6500 3091 7311 5469 23054 8454 9575 7316 551 26224 25819 2155 6256 1407 56938 2908 1408 6233 6604 1385 8648 96764 1386 2033 1453 4208 6095 5054 1454 8841 406 80205 1387 10891 7314 10135 9611 10498 85441 79718 83401 4209 6720 1374 9572 10499 4862 EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME%REACT_228063.1 EPHA-mediated growth cone collapse 4627 387 9475 6093 5747 284656 6461 7525 103910 79784 10398 2534 4637 2041 1944 2046 1945 2045 4067 1969 1946 2044 4629 1942 285220 4628 2043 2042 1943 3320 3791 25791 PERK REGULATES GENE EXPRESSION%REACTOME%REACT_18277.4 PERK regulates gene expression 23016 54512 5393 4801 22926 1965 1649 3309 4802 4800 468 167227 22894 11340 118460 51010 23404 9451 6347 51013 3484 3576 5073 467 9709 440 8570 56915 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_19305.2 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds 1317 7779 7781 27173 10864 7780 9194 9123 254428 23539 6566 55244 55356 57181 85413 6527 55630 5002 23446 26266 54716 64116 6515 4891 23516 55117 55867 56606 348932 6531 30061 115584 60482 6518 64849 66035 155184 7922 6583 81031 29985 204962 9152 9058 29988 29986 9356 101930184 6561 6563 284111 11182 80736 200010 6517 283375 6556 11254 84102 6570 345274 6571 6523 8170 6526 114134 6524 25800 9376 6584 116085 6530 91749 9843 1356 6533 51458 340024 146802 6529 6581 6582 154091 57153 6540 6536 6580 101930602 57127 55676 126969 148867 169026 6005 6514 6539 6538 6534 64924 ABORTIVE ELONGATION OF HIV-1 TRANSCRIPT IN THE ABSENCE OF TAT%REACTOME%REACT_6261.4 Abortive elongation of HIV-1 transcript in the absence of Tat 100126332 5438 5439 5436 5437 5434 5435 5431 5433 5430 5432 22916 2962 7469 5440 2963 100302242 6829 25920 5441 4686 6827 7936 9150 51497 NEF MEDIATED DOWNREGULATION OF CD28 CELL SURFACE EXPRESSION%REACTOME%REACT_11139.2 Nef mediated downregulation of CD28 cell surface expression 940 1173 VIRAL RNP COMPLEXES IN THE HOST CELL NUCLEUS%REACTOME%REACT_6198.4 Viral RNP Complexes in the Host Cell Nucleus 3303 3304 AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME%REACT_491.2 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 8379 4085 SYNTHESIS OF DNA%REACTOME%REACT_2014.3 Synthesis of DNA 5711 1017 5710 5714 5713 5719 23198 5925 5715 5716 5701 7311 5696 1026 5687 5695 3978 5700 5694 5717 5718 5688 1027 5689 51343 5111 51659 8900 5982 5981 5983 2237 5001 4999 5000 6119 4998 6118 6117 9837 4171 5720 7316 5426 10213 5425 4176 5424 5698 890 4174 4175 5699 5985 5984 1763 23595 143471 990 5721 6233 5422 84515 4173 23594 4172 5427 23649 84296 5557 57804 5558 8318 10714 81620 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 5684 5683 VIRAL MRNA TRANSLATION%REACTOME%REACT_9491.2 Viral mRNA Translation 6231 6232 6044 26784 100505503 26780 7311 116936 116938 26778 6228 6229 6227 6235 4736 6230 26771 6234 2926 84546 26809 25873 2197 100124516 94163 26791 26790 6233 6224 6223 6222 6203 6201 6202 23521 595100 6210 6205 6204 6208 6209 6206 6207 6217 6218 3921 6083 6165 6168 6137 6136 6161 6138 6164 6139 6160 6130 6133 9045 6132 6135 6167 101929876 6134 6169 85388 6143 6144 6141 6142 6147 606500 6146 619565 619499 619562 11224 100529097 26819 26815 26817 26818 26816 6129 51121 6128 6193 6194 6192 6191 26820 6124 6123 6122 6125 9349 6171 574040 6170 6173 619505 6176 100526842 6175 26811 5611 26814 6189 6188 26795 6187 595097 595099 100996747 100508408 6181 595098 6154 6155 6152 6159 8944 6157 6158 6156 VRNA SYNTHESIS%REACTOME%REACT_9497.2 vRNA Synthesis CELL CYCLE CHECKPOINTS%REACTOME%REACT_1538.3 Cell Cycle Checkpoints 5711 9133 1017 5710 5714 5713 5719 23198 5715 5716 5701 7311 5696 5687 1026 5695 5700 5694 5717 5718 5688 5689 1027 5982 5983 5001 4999 5000 246184 7465 4998 84126 5720 4171 7316 64326 10213 4176 983 5698 4174 5699 4175 5985 5984 23595 143471 990 5721 993 6233 4193 10197 5707 5706 5709 5708 5690 5705 7321 5691 5704 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 5684 5683 996 7324 9184 991 9134 898 730268 8379 51433 1111 11065 55388 8317 10926 9088 891 29882 6119 8697 6118 6117 29945 4085 51529 701 10393 84515 4173 23594 4172 7157 8318 995 51434 144715 5884 5883 63967 3364 64682 545 8881 472 5810 CELL CYCLE%REACTOME%REACT_115566.3 Cell Cycle 6232 8335 1875 8334 1874 1022 653604 3065 8337 8331 902 255626 23047 3978 55746 1163 51343 8358 5111 333932 8352 51659 8900 8359 5982 6502 8353 5981 8354 5983 2237 8338 5001 8339 4999 5000 474382 7465 4998 4331 8357 23244 8356 9837 8347 4171 5426 5425 8348 4176 8345 5424 890 8346 4174 4175 8340 5985 5984 1763 4149 23595 8343 8344 990 8341 993 8342 994 3021 4609 3020 85236 8968 8360 8362 8361 10142 8364 54145 8363 8365 8366 8970 8368 8349 8367 100616282 5928 10112 8351 9883 23383 10726 8350 25836 9493 8355 5347 3013 3012 5579 23291 723790 126961 23122 8294 23332 5931 554313 121504 3015 3014 8370 3018 3017 57405 996 51053 1058 80152 83540 7324 9184 991 699 9134 23592 898 1062 5925 1063 1060 151648 9183 9232 348235 81565 25909 55166 3796 730268 57551 8379 128312 51433 79019 55920 11130 1871 100527963 5048 1870 22919 23421 11065 55143 55839 91687 23141 64105 81930 79172 29882 6249 9212 7443 8697 80776 29945 4085 84643 3619 9793 51529 23165 25936 401541 11243 100526739 147841 9700 5520 151246 220134 6396 701 10393 378708 5422 157570 595 84515 4173 23594 4172 5427 114799 23649 84296 23063 5557 113130 57804 5558 8318 10714 81620 129401 51434 995 55055 144715 5884 54821 5883 54820 11004 63967 9735 3364 6418 79980 221496 79003 2010 64682 79682 64946 54908 10403 332 8881 5933 5810 7514 8607 1026 1027 7029 3320 84126 983 7027 5578 7298 4193 11097 23511 8815 11116 5903 1111 100847052 1736 55135 10856 55651 677835 9631 2033 1454 1459 1457 1460 91754 93426 1017 9133 5861 7014 6241 7013 5862 23345 54386 7156 1019 10783 2801 79648 81876 50511 10592 2029 10776 8615 10051 56158 8468 641 4001 4361 5889 5885 29893 84962 4683 27175 23224 55957 27030 984 3306 84057 132660 9126 23353 6847 55844 64326 64689 29781 54892 26003 23310 387893 8548 84930 140609 5519 5518 5515 5516 7175 5529 5528 5527 5525 5526 23225 7015 23279 79902 255919 23399 25913 256126 4869 56154 10388 56979 26277 4438 4439 10734 10111 23626 5500 10735 9688 5501 7329 9985 10274 9663 25777 545 11144 8290 5932 9972 672 4292 27127 472 65057 675 5711 5710 5714 5713 5719 8945 23198 6500 5715 5716 5701 7311 5696 5687 5695 5700 5694 5717 5718 5688 5689 8454 2491 57082 246184 5720 7316 10213 5698 5699 143471 5721 6233 1781 1778 203068 9662 22897 10733 80254 11064 10121 7532 55142 5905 4957 7840 5108 1453 22994 80321 9702 8021 121441 4751 7277 1069 10806 8481 22995 55722 8655 55835 55125 80184 10383 79959 10197 10382 5707 10540 5706 11190 5709 8636 5708 5690 9814 9738 5705 5691 22981 7321 55755 5704 7314 7283 5692 84131 5693 5116 95681 5702 122706 5686 11258 5685 7846 5594 5682 9861 9491 5684 8243 5683 23636 1030 64900 1719 10762 8467 26271 8480 55388 8317 10926 29935 7084 9088 891 28227 5577 6119 6118 6117 5888 23175 5566 348995 7531 53371 4927 7157 1869 8086 91750 1021 1029 27229 85378 10426 7153 1031 114791 1032 64151 728642 2305 23397 8556 5934 10133 4659 896 1859 54069 894 4605 11339 57122 51773 4218 6790 55355 55320 79866 9918 286826 79023 10844 4926 MRNA EDITING%REACTOME%REACT_1757.4 mRNA Editing 29974 339 104 103 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_115606.1 O-linked glycosylation of mucins 4582 10331 79623 4586 51301 118430 192134 27090 283463 2589 2590 2591 644378 10071 11226 168391 93010 442117 11227 26290 140687 9245 10678 100528030 84002 50614 374907 63917 2650 10610 56913 374378 4589 4588 79695 200958 64409 117248 57876 114805 4584 4583 4585 79369 51809 9331 9334 6480 29071 8693 256435 94025 140453 55568 727897 57452 84752 56667 146712 101928934 6482 6483 6487 6484 394263 143662 REVERSE TRANSCRIPTION OF HIV RNA%REACTOME%REACT_6880.5 Reverse Transcription of HIV RNA 5478 101060363 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_25330.1 Activation of GABAB receptors 2785 2786 2783 3760 3761 2784 2787 2788 100996843 3759 55970 107 108 54331 2793 109 2771 2792 2790 2770 3768 3766 100134444 112 3763 115 3765 114 2782 3772 94235 9568 3773 3762 111 2774 113 346562 2550 196883 2773 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME%REACT_1776.3 Purine ribonucleoside monophosphate biosynthesis 122622 5198 471 2618 3615 3614 5471 8833 158 10606 159 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME%REACT_22128.3 Role of DCC in regulating apoptosis 90249 9500 219699 26060 1630 1613 23604 836 1612 693222 842 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME%REACT_20594.2 Unblocking of NMDA receptor, glutamate binding and activation 88 1742 816 817 2902 818 10142 2904 2890 4747 815 2892 2891 2905 2906 2903 2893 PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME%REACT_121079.2 PI and PC transport between ER and Golgi membranes 23760 PLC-MEDIATED HYDROLYSIS OF PIP2%REACTOME%REACT_2080.4 PLC-mediated hydrolysis of PIP2 5336 TAT-MEDIATED HIV ELONGATION ARREST AND RECOVERY%REACTOME%REACT_6344.5 Tat-mediated HIV elongation arrest and recovery 1025 5438 100126332 5439 5436 5437 5434 5435 8178 5431 5433 904 5430 5432 6749 2962 7469 5440 2963 100302242 6829 25920 5441 11198 6827 7936 9150 6921 6924 6923 6917 51497 CAM-PDE 1 ACTIVATION%REACTOME%REACT_15408.1 Cam-PDE 1 activation 5136 801 805 808 5137 5153 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_120800.2 Dermatan sulfate biosynthesis 63827 92126 29940 10675 113189 1463 1464 10090 633 1462 1634 SIGNALING BY RHO GTPASES%REACTOME%REACT_11044.2 Signaling by Rho GTPases 64411 391 393 392 395 394 116985 10928 55114 10276 51306 79658 171177 64333 23092 116984 58480 51291 80728 1124 79822 1123 9886 9901 553158 7410 89846 9743 23263 29984 7074 7204 10144 57569 90627 89941 1894 9912 29 8874 7409 644086 29127 84144 101928361 101928667 23229 25791 55843 9754 9459 8997 23779 54509 9938 26230 11214 89839 2 57449 10451 64857 2245 158763 57381 221472 388 387 27237 389 5881 23365 6453 23221 5880 257106 3633 4650 2909 58504 2665 2664 115703 85360 57522 5924 5296 117289 9322 84986 4983 57514 4168 6654 4649 23433 100288637 396 613 343578 94134 23526 9181 399 998 4952 93663 397 398 121512 83478 9828 57636 55288 101930241 91614 23380 50649 6655 84033 9826 23370 50650 9824 9411 10395 55789 ETHANOL OXIDATION%REACTOME%REACT_34.4 Ethanol oxidation 217 216 130 124 131 84532 127 55902 125 126 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_120734.2 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription 4609 1030 1875 1874 1025 3065 1024 4221 60436 54778 7050 7311 6667 100527943 5054 892 4092 904 905 3726 7029 7314 25937 4088 7316 4089 5933 7027 4087 6233 L1CAM INTERACTIONS%REACTOME%REACT_22205.1 L1CAM interactions 2048 5604 5605 8829 5058 1808 1785 7410 5879 1956 26052 285643 4684 1211 5595 6327 6329 1741 1742 3688 6195 6197 6196 8506 6709 6708 27255 6710 6712 3672 3673 6334 6332 5594 6331 6711 6328 1739 4478 6326 6335 8986 55800 10048 160 8515 85390 57731 10752 8828 163 51332 6386 7430 6324 6323 161 23114 5962 100133941 1641 3912 214 3897 57698 8650 3678 3690 3786 3685 85389 3915 3785 288 286 287 3674 284217 1272 3680 4897 1173 101928143 1175 6456 27330 9252 6900 101927462 3312 1463 1459 1457 101930388 1759 24137 1460 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME%REACT_1574.2 Cyclin E associated events during G1 S transition 5711 1017 5710 5714 5713 1022 5719 9134 898 5925 6500 902 5715 5716 5701 7311 5696 5687 1026 5695 5700 1163 5694 5717 5718 5688 5689 1027 8454 8900 9088 6502 7465 4331 5720 7316 10213 5698 890 5699 4149 993 5721 6233 4609 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 5686 5685 5682 9861 9491 5684 5683 HORMONE LIGAND-BINDING RECEPTORS%REACTOME%REACT_16942.1 Hormone ligand-binding receptors 1081 2796 3973 2492 2488 7253 3972 114814 2798 2797 7252 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME%REACT_6837.2 Regulation of APC C activators between G1 S and early anaphase 5711 996 1017 5710 5714 5713 7324 5719 9184 8945 991 23198 6500 5715 5716 5701 7311 5696 5687 5695 730268 5700 5694 51433 5717 5718 5688 5689 8454 26271 11065 51343 8900 891 29882 246184 8697 29945 4085 5720 7316 10213 51529 5698 983 890 5699 143471 701 5721 10393 6233 5347 51434 10197 5707 5706 5709 5708 5690 5705 7321 5691 64682 5704 7314 5692 5693 5702 8881 122706 5686 5685 5682 9861 9491 5684 5683 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_1230.4 Platelet Adhesion to exposed collagen 8515 3688 2812 2811 7450 2815 2814 2207 3672 3673 2534 51206 4067 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_200783.2 Myoclonic epilepsy of Lafora 10331 3099 3098 126792 3073 3074 55746 2538 2539 3038 9394 8972 3037 3036 2720 11181 2719 727936 4958 3425 1634 3423 9348 63827 8908 5519 5518 6527 5515 5516 8509 8702 7175 9883 8704 8703 9331 9334 4969 6515 2997 5528 6513 2998 10057 29940 2990 64579 2817 2132 2131 5106 5105 23225 960 55454 6888 7360 6476 10082 6482 6483 6487 6484 55276 1836 2992 2023 135152 51363 5223 5224 5226 2203 10894 5230 200010 55576 8402 6448 8789 23165 337876 23279 90161 79902 26330 22934 64711 375790 5549 1463 129401 4669 51000 8534 50515 7957 4060 5507 9060 9688 55790 7086 2683 9972 92126 55501 9061 54480 3938 23563 8604 2239 221823 3373 79586 2646 9469 3339 7311 9653 3340 92579 4191 6383 11285 4190 10165 10678 9435 378884 10675 3795 2632 283464 8372 100616124 7316 6120 9957 11041 9956 9955 633 2806 2805 11046 6233 79369 801 27087 805 5255 808 5256 347734 5257 11081 5214 229 226 411 176 178 6382 643853 5236 648740 6385 8021 26035 10855 2821 10861 2262 3101 60495 7314 5213 5210 11097 5208 5207 6518 23511 5211 23636 5209 25796 6548 277 278 56548 276 2542 266722 10762 10402 280 22856 221914 5903 222537 93010 5837 5834 10090 279 5836 8480 6576 6517 5260 2799 57818 8692 5568 5567 6523 5566 6526 6524 26229 5261 230 5091 348995 5634 7167 166012 9631 11261 3161 113189 53371 2027 2026 9951 9953 4927 9672 2597 8086 2331 2584 2582 6514 1464 2592 5631 1462 1468 2645 4166 57122 79411 79023 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_23916.1 Signal regulatory protein (SIRP) family interactions 8935 55423 5777 100653194 5781 7305 10326 2185 2533 961 5747 140885 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME%REACT_19279.1 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 6237 23396 55558 8829 10371 91584 2242 5362 9855 5361 27289 2534 5879 7094 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME%REACT_22107.2 RNA Polymerase II Pre-transcription Events 728340 1022 5438 1025 5439 5436 902 5437 5434 5435 904 905 6872 6874 7469 11198 6873 138474 4331 6827 6917 6908 6877 51616 2968 6881 2967 6878 100126332 6875 6880 6883 6884 6882 8178 2957 5431 2959 2958 5433 5430 5432 22916 2960 2961 2962 6749 5440 2963 100302242 6829 5441 25920 4686 7936 2068 102157402 9150 6921 2071 6924 83860 6923 51497 2965 2966 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_12433.1 Nuclear Events (kinase and transcription factor activation) 5600 9252 5528 1385 1845 1848 6195 1849 466 6197 1846 2002 6196 1432 5519 5518 4205 5515 4208 5516 5598 5594 9261 5595 STIMULI-SENSING CHANNELS%REACTOME%REACT_160189.4 Stimuli-sensing channels 54822 80036 80727 1179 1180 1181 54795 94015 63982 57578 121601 10345 101929373 4308 10110 53373 266675 9629 144453 51393 133308 59341 40 7311 7809 22802 1193 162514 29850 41 1184 1183 285335 1182 1188 1187 1186 1185 11059 55283 55503 6263 6262 56302 6261 285175 6446 55515 7439 55129 100533105 7442 79054 150159 65266 7316 26133 65267 65268 55107 219931 9635 196527 7223 7224 1831 7226 65125 140803 51802 284525 5894 6233 255231 10786 7220 203859 338440 9311 8989 23678 6340 6339 6338 57113 6337 54831 50636 259232 57192 57719 28962 57101 7314 7225 7222 23327 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME%REACT_1768.5 Processing of Capped Intronless Pre-mRNA 100302196 84967 51692 6628 6634 6635 11051 6636 53981 8106 6637 22916 134353 7884 4686 10914 1477 79869 25888 1478 29894 10978 51585 100126351 1479 REPRODUCTION%REACTOME%REACT_163848.2 Reproduction 2515 101930343 22917 11085 126123 6677 157855 113177 928 100129669 117144 84329 5016 7783 378807 117155 49 8747 8748 257062 7784 2683 284359 57829 347732 57828 79820 SIGNALING BY VEGF%REACTOME%REACT_12529.1 Signaling by VEGF 857 5603 9475 6093 5063 5062 5604 5747 5605 4690 8829 10006 5058 5921 25759 10458 1398 7410 3265 5879 9844 5335 3320 7409 3791 26999 6300 10810 5580 983 7867 2475 1003 5894 5578 253260 801 805 7297 808 3708 3728 3709 1432 3845 6461 64223 4893 101060747 3717 5170 57761 5595 5600 7422 5579 1495 2185 63916 1500 5594 5829 558 8828 8877 7423 8440 9564 2277 5228 2321 2324 7424 1535 5291 9047 1536 3569 3690 653361 3685 2534 3570 117145 79109 5290 4689 9261 4688 5781 10451 10152 5568 10787 5567 4846 5566 3710 5590 10163 387 8936 1793 7529 5296 3315 3716 5295 10000 207 208 998 55845 BINDING AND ENTRY OF HIV VIRION%REACTOME%REACT_6903.3 Binding and entry of HIV virion 5478 920 101060363 7852 1234 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_9510.3 FGFR3c ligand binding and activation 2247 2246 2249 8823 26281 2254 8817 8074 SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%REACT_150201.2 Synthesis of 12-eicosatetraenoic acid derivatives 239 246 2879 242 2877 2876 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_11202.2 Vitamin C (ascorbate) metabolism 6515 6513 9446 1528 9962 9963 119391 1727 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_25120.1 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling 3665 7336 3654 51284 51135 54106 7334 7335 51311 170506 4615 7189 HATS ACETYLATE HISTONES%REACTOME%REACT_172610.2 HATs acetylate histones 26610 93624 8335 54556 8334 8607 284058 60 55683 653604 55689 23338 8337 8969 86 3054 6314 10445 8331 57634 54859 8464 80314 255626 7994 23774 55250 55257 56943 112869 8518 440689 57325 55578 27154 64769 8329 8089 10902 8520 117143 8332 8358 55140 333932 8330 8352 8359 8473 51147 8353 8336 8354 7862 8338 8339 9575 8357 8356 8347 8348 8345 8346 8340 8343 8344 8341 8342 85236 6881 8968 8360 8362 6880 8361 6883 8364 8295 8363 8365 8366 8970 8368 8349 8367 8351 8350 8355 3013 3012 723790 126961 8294 102157402 5931 8850 554313 121504 8370 3018 3017 2648 128312 10856 6871 1386 10524 2033 1387 27097 10933 23522 56970 85235 9767 79960 55929 10943 54934 101929776 79595 55167 100303755 23587 6944 23326 10629 51230 9913 26009 9643 11143 1810 10474 92815 339287 84148 221613 317772 51562 84289 11091 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_22442.1 Interleukin-1 signaling 57161 8945 10392 51135 57162 5604 6500 8767 4615 257397 6416 8454 3656 23118 8517 7336 3654 11213 10454 7850 246330 3554 64127 4215 5608 3557 54472 9978 3553 8878 4790 3552 7334 1326 7335 1147 6885 79155 3551 7189 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_25162.1 Interferon alpha beta signaling 5696 5781 3133 3665 5777 3661 3107 3106 8651 7297 9636 103 4599 3105 6773 3442 3716 3440 3433 3441 3434 8638 10581 3437 3135 10379 3394 3439 3451 4938 4939 4600 3662 3443 8519 3444 1958 54739 3452 3454 3448 3134 6041 3449 11274 3445 4940 3446 10410 3430 51447 9021 3429 2634 3660 2537 5770 3659 3663 3669 3456 3664 MINERALOCORTICOID BIOSYNTHESIS%REACTOME%REACT_11047.3 Mineralocorticoid biosynthesis 1584 1081 1585 1589 3283 3972 3284 TRANSPORT OF FATTY ACIDS%REACTOME%REACT_23892.1 Transport of fatty acids 28965 376497 10999 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_150149.2 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 5730 6916 9536 10728 5742 5740 5743 1582 127281 3248 873 22949 27306 8644 REGULATION OF GENE EXPRESSION IN ENDOCRINE-COMMITTED (NEUROG3+) PROGENITOR CELLS%REACTOME%REACT_13650.1 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells 4821 3642 4760 5078 50674 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_169325.2 Oncogene Induced Senescence 1030 1019 57690 2114 7157 1869 7311 6667 4193 1021 192669 1871 23112 1870 4343 5595 1029 192670 1031 1032 26523 7314 27327 7316 7027 5594 2077 2113 3397 6233 DEADENYLATION OF MRNA%REACTOME%REACT_20514.1 Deadenylation of mRNA 652965 9924 25904 55571 652966 677847 9125 26781 255967 23019 6043 619567 619568 10605 9337 1981 100302143 1974 1973 1977 1975 85456 57472 29883 4848 5073 4849 26986 9775 246175 4850 DEPYRIMIDINATION%REACTOME%REACT_1405.2 Depyrimidination 4913 8930 10309 23583 6996 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME%REACT_347.3 RNA Polymerase III Transcription Initiation From Type 1 Promoter 55814 27297 9330 5437 84265 5434 5435 101060521 661 51082 55718 9328 5440 9329 171568 5441 9533 10623 10621 51728 11128 10622 55703 2972 6908 2976 2971 2975 DNA STRAND ELONGATION%REACTOME%REACT_932.6 DNA strand elongation 5422 84515 4173 4172 23649 84296 5557 57804 5558 3978 8318 10714 5111 51659 5982 5981 5983 2237 6119 6118 6117 9837 4171 5425 4176 5424 4174 4175 5985 5984 1763 SIGNALING PATHWAYS%REACTOME%REACT_111102.4 Signaling Pathways 1796 29904 6198 7248 51719 81617 101930123 6794 5565 5564 5563 5562 92335 5571 54106 55437 6009 51422 57521 53632 27248 1211 10125 5579 5970 4792 4790 6885 3551 23421 10018 5533 857 8607 2239 26020 9249 83875 3339 9040 2652 8395 10170 3549 9227 79971 3320 79577 2280 6121 9958 2060 101929777 343637 222236 6382 6385 611 51384 182 3062 8841 8644 6597 388585 2262 50964 5929 7471 26018 7476 8630 157506 7473 7474 7477 7478 7479 7472 7276 8608 7475 160851 5034 5583 9002 23072 846 84133 1241 57121 3814 1133 431704 84109 2915 139189 2911 23462 60675 284654 84432 10402 84634 51109 115557 9170 7415 2796 8650 128674 185 58513 2828 83464 2829 10014 51107 10287 10886 10316 64220 624 10800 57154 2798 1272 2797 23620 10817 10887 2867 6863 57680 2865 8658 8477 6915 347148 3061 2869 257313 10013 23566 102 81029 2693 5724 5997 2862 3060 57105 23493 387129 5664 29933 142678 2520 30011 146 147 90780 148 2925 64106 594857 1609 1607 54567 1608 5499 6846 1234 1606 8620 51339 221955 51564 680 8527 55851 2150 886 885 8526 8525 55824 6865 6866 6869 747 6870 2149 5731 2033 5737 9672 151056 55869 101927462 5617 1454 4775 1459 1457 28514 24 81847 6375 83933 9162 56413 623 64840 10874 9187 4773 129521 4772 2837 1128 7201 7200 1910 56923 1460 64407 1908 2847 10911 1906 7855 5367 79412 1907 10254 1909 10252 5406 222545 8111 1902 4738 4295 4828 54361 4829 101929368 23220 4922 80326 114814 887 7852 84539 2151 80319 53630 4923 3714 54894 54492 7048 7046 56288 3949 7040 3091 51699 56937 123169 101060233 113878 11171 2535 9844 1857 1856 3791 9846 6347 1855 2719 796 80351 1292 9559 1645 3576 145226 9759 29967 11197 1291 101927965 6259 9101 83737 1293 6017 79885 4040 50855 56998 9459 4036 9148 9146 728458 9736 11140 4035 4023 3728 10273 283149 8295 6461 50848 83999 8085 50846 5584 4041 29924 1208 8065 8452 1495 1840 9021 10082 1445 27198 338442 8843 1500 6487 6484 84870 85455 5829 10956 8313 160 55366 59352 8877 163 408 409 161 340419 7480 7481 7482 7483 7484 607 8323 8325 8321 8322 51377 59349 6772 50999 6774 26508 1173 7015 26108 101928143 1175 57016 8788 6456 22943 5590 57530 50700 6464 57534 25805 6400 1282 440193 1298 5956 1285 5959 8549 375790 1284 27123 1297 10524 1287 27121 51009 6422 5534 5948 5947 147111 131873 5949 1299 5950 1286 101930388 1109 6423 256076 9734 5530 5532 5500 5501 4647 92737 2683 9070 1455 89780 84447 55737 55733 57758 23385 5711 5710 5714 5713 1452 5719 8945 2932 7089 23198 139285 7088 6500 5715 5716 1499 5701 7311 5696 5687 5695 5700 166 5694 6932 6934 5717 5718 5688 5689 8454 8312 5720 7316 10213 324 5698 83439 9978 5699 7090 7091 10023 143471 5721 6233 1487 1488 23401 10197 5707 3973 2492 5706 5709 7253 5708 5690 5705 5691 5704 2185 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 51176 5684 5683 336 337 6868 121214 8828 3280 331 8038 25776 221914 3690 8724 3685 6469 345 3674 348 8027 23645 3292 344 9500 1875 5603 10235 1874 729230 10006 10458 100527943 26052 9794 26999 6300 10810 1235 4609 7006 4221 7050 55534 3479 3480 4092 23112 7422 3726 3481 4914 2889 1399 727 718 4853 4854 4855 84441 1604 4851 4088 10152 4089 10787 4087 10163 5330 8936 1793 5332 5331 7529 6667 7534 1387 1759 27327 5933 55845 7514 8829 2242 64750 7029 26523 5580 22938 7027 5578 5241 79718 5028 2099 5030 27334 2846 53829 9934 60436 64805 5029 10161 142 1111 6194 5031 5032 2840 23327 3315 3516 3625 3624 2488 7058 7057 10959 5986 56983 4242 23509 5870 3955 150786 5900 5898 5899 4915 135 117 116 5063 59340 3274 11255 3269 4690 1020 5607 6014 10126 57498 6016 2695 6497 6498 7323 7321 8239 23596 10019 4318 10603 10076 9306 10750 27161 5995 221391 94233 10692 10046 7094 192669 192670 1215 2886 2241 219437 64411 6002 391 219417 393 219436 392 2914 395 283365 394 2913 116985 10928 2912 55114 83756 219429 10276 219432 51306 126541 171177 219431 64333 6000 23092 219438 116984 58480 6001 2887 122740 51291 122742 80728 122748 53358 1124 346517 79822 3643 79290 25759 1123 1398 79295 9886 9901 79296 553158 219428 50839 7410 26184 89846 9743 346528 23263 346525 29984 6019 125958 7074 7204 8928 10144 9340 2532 57569 90627 219869 219469 89941 1894 79274 9912 8324 219482 5734 144165 29 8874 219484 23513 5732 7409 644086 2920 29127 219875 219873 84144 101928361 219874 101928667 219464 25791 219870 2921 55843 9754 154810 219447 4919 219865 1213 119687 1212 5592 119682 219858 219473 219477 219479 2918 7976 119679 23002 5216 3640 57216 119678 2917 2780 219453 2775 2919 51701 2916 4920 390431 390432 390437 5364 390038 537 390433 120586 5368 390445 390037 390036 390442 815 390441 26189 50838 50837 26188 50836 341152 50840 6195 441608 50832 50833 6197 50834 50835 50831 6196 284433 976 5327 441639 5340 119694 347468 390429 119695 390538 119692 1815 1816 1813 1814 84894 1812 390436 390439 8590 56656 504190 391107 391109 135941 338557 504191 135948 2922 135946 401427 3952 391114 391112 121275 504189 81127 390651 26533 26532 26539 26538 284521 26531 56670 134083 391121 135924 51052 26524 26529 441670 441669 127623 6364 2243 6363 8601 6361 120065 120066 6366 2 6367 6752 6753 2841 6360 6751 390323 390321 6750 155 6348 6349 3827 2266 151306 6351 6352 2244 153 154 80835 80834 6356 151 2852 26707 2853 5196 6354 81168 127608 130399 79346 442185 442186 442184 81169 26595 128366 7450 128367 2147 128368 79345 7059 143496 5443 128360 7060 51083 79339 79334 402135 5733 81193 219487 79324 219493 442179 127617 5746 5741 5744 5745 1392 51421 1395 1394 5727 4283 5729 5726 284532 26534 7932 283869 729966 134860 414062 134864 26575 26574 256933 128372 128371 144125 144124 10589 11211 79310 79317 392133 125962 392138 125963 10563 1081 6199 9294 9402 347169 401667 3815 9290 219965 219960 347168 81797 219986 5581 119772 23035 9283 5582 572 119774 401665 5604 401666 401663 5605 2064 150681 81282 1950 286365 2335 1026 79470 65944 6850 81697 81696 81285 219957 3265 219956 5879 219959 145957 219958 2931 79473 1027 256892 1956 219968 6714 2309 53637 4158 5156 4543 4544 8660 4160 5335 4161 11108 10468 388761 441911 26692 5137 2069 26693 26696 80310 4157 5155 814 4159 254786 254783 7249 1269 10803 983 27202 2475 1268 26686 255725 11343 1839 4145 286362 3932 26658 23239 26659 842 26664 343406 1147 23236 50852 283093 5894 283092 186 253260 26716 156 7297 187 2826 2834 2833 940 2832 3084 685 2831 6372 942 6370 941 2641 6374 2642 6373 23538 6376 390326 390327 84152 6788 3845 84335 6789 8622 64223 136 133 4893 101060747 81300 134 3717 4193 117579 138799 9542 60485 930 8643 5170 10850 5159 341276 57761 6754 10718 6755 127066 127068 127069 219952 81309 140 127062 127064 2863 2861 390649 390648 196335 81315 127077 127074 219983 9288 219981 219982 119764 119765 9287 338662 338675 338674 389090 119749 127059 219954 9628 100996542 8471 4995 4994 340980 392390 392391 10798 387748 343171 343173 343172 81431 343169 339403 158131 392376 2768 10272 283160 81406 259287 283159 259289 259286 799 797 83551 259285 259296 259291 2781 259295 146850 8997 259293 23779 259292 54509 283162 9938 259294 26230 390271 11214 259290 89839 9113 57449 390275 10451 390265 64857 58191 390261 390264 138881 390260 390266 5906 138882 138883 283111 283110 392392 120793 120796 9138 353164 390199 390197 390195 81392 4889 4886 4887 7252 81399 2245 81228 158763 7432 57381 10022 221472 7433 7434 388 91 387 26689 27237 26687 389 5881 26211 26212 23365 6453 341799 23221 441932 5880 441933 26682 257106 3633 285659 4650 26683 2909 81248 58504 26219 1237 2665 1238 2664 115703 1233 85360 1236 5697 57522 5924 1232 117289 26248 9322 121129 84986 6343 6344 4983 57514 1230 4168 121130 6654 26245 4649 8698 120776 23433 100288637 120787 729759 396 613 120775 26648 343578 94134 26246 23526 653166 9181 55233 51289 399 998 719 390201 4952 1131 338398 93663 27199 397 728 398 121512 127385 83478 319100 4993 9828 57636 4992 55288 4991 101930241 8484 91614 165140 55914 23380 50649 283189 4974 6655 84033 138805 138804 9826 3972 138803 23370 50650 138802 4987 9824 9411 4988 10395 4985 55789 4986 390058 390059 390054 390053 10203 79924 390154 390155 390152 390151 442361 390157 390162 390167 390168 390134 54778 3579 6610 3577 393046 11251 390142 79541 643 10193 79544 390144 79549 390148 9034 403284 9038 403282 92597 10672 390113 100996758 8388 8387 8383 8386 8391 8390 8389 8392 283694 5908 1524 130075 283297 162998 8811 10636 390883 390894 390892 10663 282775 282763 101927057 390882 59350 391189 2776 8862 282770 8326 79501 391195 391196 391190 391192 391191 2015 2740 84658 124538 8786 8787 391194 57007 5999 5996 5150 26740 26338 51592 26339 2767 283617 2769 56477 402317 26333 1132 26737 1981 27115 1129 5151 5154 26735 26341 5600 6696 54429 5142 254879 5141 5143 343563 5144 2692 5294 81318 81328 2691 30817 9612 5539 5173 9611 5179 338755 4852 81341 442194 442197 442191 81327 2696 6608 126370 4099 390174 390191 390190 390181 338751 6907 10411 5660 9261 1978 1977 1975 26494 26493 26496 26495 57142 3164 441308 26492 26476 391211 100505585 5473 85397 26497 341416 341418 79482 403253 403257 81472 4314 143503 81061 54518 1903 122042 143502 1901 256144 341568 256148 121364 81458 401973 403278 403277 79490 10268 51554 403273 81469 403244 10266 892 10267 81470 403239 81466 4734 390083 23286 390084 2587 113091 3627 81442 81448 81050 401993 401994 401992 390093 261734 254973 403274 390061 81099 11069 390063 284383 390066 390064 390081 390067 390078 390077 390073 390075 390079 390072 390082 392309 9630 6295 2779 10988 9397 2979 2978 5588 1785 5158 2339 23173 2342 388531 9626 5145 100529261 2864 5957 2986 6010 6011 1258 5148 1259 3000 4836 5475 801 805 808 1385 183 26281 10818 23533 10253 2247 150 2246 2249 152 2255 8823 673 27006 2251 2252 867 2254 2248 8817 8569 8074 5594 1030 1025 1024 904 905 5577 5576 5573 5568 5567 5566 551 554 5575 57690 10413 5054 25937 5494 3066 8335 8334 653604 3065 8337 79658 5062 8331 255626 6777 8503 8358 11059 333932 8352 8359 8353 8354 8338 8339 474382 8357 8356 8347 8348 8345 8346 8340 8343 8344 8341 8342 3021 3020 85236 8968 8360 8362 8361 8364 54145 8363 8365 8366 8970 8368 8349 8367 100616282 8351 8350 8355 5595 3013 3012 2817 723790 126961 8294 8850 554313 63916 121504 3015 3014 8370 3018 3017 558 7423 8440 9564 2277 5228 527 528 2321 2324 7424 1535 526 9047 2648 525 1536 523 9114 653361 128312 529 9296 51382 2208 4192 50617 23545 3002 1871 4689 10312 4688 245973 8992 245972 127124 101927180 533 534 535 90423 51606 155066 9550 595 553 5020 552 6778 8878 1443 1444 51741 2670 6387 2690 2689 2688 5770 5618 1447 1442 5021 1003 5593 51764 2791 3708 3709 5140 1432 5138 5519 5139 5518 5515 5516 57113 2778 10681 5153 10846 5529 5528 5527 5525 5526 7225 7222 5125 5046 5045 100507472 4803 2549 5291 5293 3569 3667 2534 5728 3570 117145 79109 5290 4343 5781 59345 487 650 5136 64388 5777 11167 9765 4846 4090 5321 4093 3710 4086 4091 659 5739 657 658 489 488 93 92 9241 7804 91851 50940 9350 2785 2786 2783 2784 2787 2788 55970 107 108 54331 2793 109 2771 2792 2790 2770 2782 9568 2774 2550 2773 8290 9475 6093 5747 7525 5058 5921 6383 4067 23118 112 1845 115 1848 114 3654 1849 94235 466 111 113 1846 346562 23229 196883 7867 6285 5598 8651 5599 7189 3354 3358 3357 3350 3360 3361 3362 3363 3352 3356 3351 3355 3630 335 338 6288 9110 5289 9414 7082 30849 835 152831 9252 2264 9965 27018 4804 7531 836 2002 8767 4615 7157 1869 3725 4205 351 4208 2358 5296 2359 301 2357 3716 6776 50865 5295 10000 207 208 3375 2308 AXIN MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX, ACTIVATING WNT SIGNALING%REACTOME%REACT_228098.1 AXIN mutants destabilize the destruction complex, activating WNT signaling 5711 5710 5714 5713 1452 5719 3065 8945 2932 7089 23198 139285 7088 6500 5715 5716 1499 5701 7311 5696 5687 5695 5700 166 5694 6932 6934 5717 5718 5688 5689 8454 8312 5720 7316 10213 324 5698 83439 9978 5699 7090 7091 10023 143471 5721 6233 5519 5518 5515 5516 5529 1487 5528 1488 5527 23401 10197 5707 5525 5706 5709 5708 5690 5705 5691 5704 5526 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 51176 5684 5683 THE NLRP1 INFLAMMASOME%REACTOME%REACT_75927.1 The NLRP1 inflammasome 598 596 22861 PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME%REACT_19348.1 Proton-coupled neutral amino acid transporters 206358 153201 NEUROTRANSMITTER CLEARANCE IN THE SYNAPTIC CLEFT%REACTOME%REACT_13583.2 Neurotransmitter Clearance In The Synaptic Cleft 6582 590 1312 217 6531 6580 4128 43 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_21326.1 Activation of the AP-1 family of transcription factors 5600 3725 5601 5602 1386 5594 5599 2353 5595 1432 HYALURONAN BIOSYNTHESIS AND EXPORT%REACTOME%REACT_121301.2 Hyaluronan biosynthesis and export 3038 10057 3037 3036 DEGRADATION OF AXIN%REACTOME%REACT_200766.2 degradation of AXIN 5711 5710 8313 5714 5713 5719 23198 5715 5716 5701 7311 5696 5687 5695 5700 5694 5717 5718 5688 5689 8312 64750 8658 5720 7316 80351 10213 5698 5699 143471 5721 6233 81847 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 5684 5683 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%REACT_85.3 p53-Dependent G1 S DNA damage checkpoint 5711 5710 1017 5714 5713 5719 9134 23198 898 5715 5716 5701 7311 5696 5687 1026 5695 5700 5694 5717 5718 5688 5689 1027 5720 7316 64326 10213 5698 5699 143471 5721 6233 7157 4193 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 122706 472 5686 5685 5682 9861 9491 5684 5683 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_75822.2 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6231 6232 6044 26784 23049 100505503 26780 7311 116936 26778 116938 6228 6229 6227 6235 4736 6230 26771 6234 84546 5976 26809 25873 2197 100124516 94163 26791 26790 6233 22794 9887 6224 6223 23293 6222 6203 6201 5518 6202 5515 23521 1981 595100 55110 6210 22916 6205 6204 6208 6209 6206 6207 6217 6218 3921 6083 6165 6137 6168 9939 6136 6138 6161 6139 6164 2107 6160 101060386 6130 6133 9045 6132 6135 6167 101929876 6134 6169 85388 6143 6144 6141 6142 6147 606500 6146 619565 55181 619499 619562 552900 4116 100529097 11224 23381 26819 101060589 26815 56006 26817 26818 26816 6129 51121 6128 6193 6194 6192 6191 26019 5520 26820 6124 6123 6122 6125 9349 6171 574040 6170 619505 6173 100526842 6176 6175 26811 26814 6189 6188 26795 6187 595097 595099 10921 100996747 4686 100508408 6181 595098 65110 23708 6154 6155 26986 6152 9775 6159 8944 6157 6158 6156 65109 GLOBAL GENOMIC NER (GG-NER)%REACTOME%REACT_2253.3 Global Genomic NER (GG-NER) 728340 1022 2968 2967 5427 7507 7508 902 5887 57804 2067 3978 10714 5111 5982 5981 5983 6119 4331 6118 6117 1643 2068 5426 2071 5425 2073 1642 5424 5985 5984 2965 2072 2966 BIOSYNTHESIS OF A2E, IMPLICATED IN RETINAL DEGRADATION%REACTOME%REACT_160194.2 Biosynthesis of A2E, implicated in retinal degradation 222236 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME%REACT_19375.3 Free fatty acids regulate insulin secretion 2864 2767 2769 5330 5331 9630 2776 23236 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_160315.4 Regulation of PLK1 Activity at G2 M Transition 9133 8945 11116 6500 7311 84962 5048 8454 22919 891 3320 5577 7316 9793 5566 983 6233 1781 1778 203068 9662 22897 10733 7531 80254 11064 10121 10142 7532 55142 4957 7840 5108 1453 5518 22994 80321 9702 121441 4751 7277 1454 1069 10806 8481 22995 55722 8655 5347 55835 55125 80184 10383 79959 54820 10382 10540 23291 11190 8636 9814 9738 22981 5500 55755 7314 7283 84131 23332 5116 10133 95681 4659 4218 11258 6790 7846 79866 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_1857.6 Cyclin A B1 associated events during G2 M transition 995 1017 9133 8900 1022 9088 891 2305 7465 902 4331 5519 5518 983 5515 890 5516 5520 993 5347 7514 994 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME%REACT_16967.1 Post-chaperonin tubulin folding pathway 1155 347733 7280 101929597 10383 81027 6905 10382 10376 10381 7278 84790 6902 6904 6903 84617 402 113457 7277 7846 MITOTIC SPINDLE CHECKPOINT%REACTOME%REACT_2137.3 Mitotic Spindle Checkpoint 11065 51434 996 7324 9184 991 29882 7321 64682 246184 8697 29945 4085 8881 51529 730268 8379 51433 701 10393 SIGNAL AMPLIFICATION%REACTOME%REACT_20524.2 Signal amplification 5028 2785 2786 51764 2783 2784 2787 2788 2791 64805 9630 1432 2767 55970 2769 54331 2793 10681 2771 2792 2790 2770 10672 6915 59345 2782 94235 346562 2773 5321 2776 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_21368.2 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 3656 23118 8517 5601 3654 5602 10392 8767 10454 257397 6416 64127 5599 5609 6885 7189 LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME%REACT_20617.1 Localization of the PINCH-ILK-PARVIN complex to focal adhesions 3611 3688 55742 5829 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_13537.2 p75NTR signals via NF-kB 4804 3654 7314 8767 4615 4803 7316 7311 8878 5584 5970 4792 4790 3551 6233 7189 KINESINS%REACTOME%REACT_25201.1 Kinesins 1062 3796 10112 9493 3797 64837 22920 11004 64147 81930 3833 3832 3835 29127 3831 147700 9371 24137 11127 84643 285643 26153 56992 89953 3799 3798 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%REACT_20639.2 Deadenylation-dependent mRNA decay 54512 9924 55571 5393 27257 9125 26781 27258 6043 28960 167227 22894 619567 619568 100302143 1974 1973 118460 1977 1975 23404 57472 54464 23658 4848 1656 4849 246175 4850 652965 23016 25904 652966 25804 677847 51690 23644 219988 11157 255967 23019 57819 10605 9337 196513 1981 11340 55802 51010 85456 80153 51013 29883 5073 26986 9775 56915 CERAMIDE SIGNALLING%REACTOME%REACT_13806.2 Ceramide signalling 6610 4804 4803 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%REACT_150237.2 Phosphate bond hydrolysis by NUDT proteins 131870 11164 55270 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_12582.2 Phosphorylation of CD3 and TCR zeta chains 3115 100509457 3117 28577 3119 3118 916 55824 915 100507709 3113 3122 920 917 100996809 100507714 101060835 3120 3123 28639 5788 28755 1445 3125 3126 3127 3932 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_1628.2 Transcription-coupled NER (TC-NER) 728340 1022 2968 2967 5438 5439 5427 5436 56949 902 57804 2067 1161 5437 3978 5434 5435 10714 5431 5433 5430 5432 5111 5982 5981 5440 5983 5441 6119 4331 6118 6117 2068 5426 2074 5425 2071 2073 5424 6917 5985 5984 2965 2072 2966 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_1357.3 Base-free sugar-phosphate removal via the single-nucleotide replacement pathway 4913 4968 8930 10309 4350 23583 5423 328 6996 4595 ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME%REACT_8001.2 Alternative complement activation 629 718 1675 3004 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_121315.2 Glycosaminoglycan metabolism 23563 10331 2239 3373 79586 9469 3339 126792 9653 3073 3340 3074 6383 11285 10678 9435 3038 9394 10675 3037 3036 2720 283464 8372 100616124 2719 727936 4958 9957 11041 9956 9955 633 3425 1634 3423 11046 79369 27087 9348 347734 11081 411 176 63827 6382 643853 6385 8509 8702 26035 8704 8703 9331 10855 9334 4969 10861 2262 10057 29940 2990 64579 2817 2132 2131 60495 960 55454 10082 6482 6483 6487 6484 1836 6548 135152 56548 266722 10402 51363 22856 221914 222537 93010 10090 10894 55576 2799 6448 8692 337876 26229 90161 64711 166012 11261 375790 3161 113189 5549 9951 9953 9672 1463 4669 2331 51000 8534 50515 4060 1464 9060 1462 55790 2683 92126 55501 4166 9061 79411 54480 ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME%REACT_150128.3 Electron transport from NADPH to Ferredoxin 112812 2232 2230 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_25374.4 IKK complex recruitment mediated by RIP1 330 23643 148022 7322 329 11035 100302736 7311 7323 7336 8517 7099 7321 7314 8737 929 7316 353376 7098 7334 7335 1147 7189 3551 6233 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_25380.6 IRAK2 mediated activation of TAK1 complex 3656 257397 7311 7316 23118 7314 6885 10454 6233 7189 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_120829.2 Acyl chain remodelling of PC 50640 64600 123745 26279 81579 151056 8605 50487 100137049 79887 79888 100652777 11145 255189 54947 129642 30814 283748 5320 5322 5319 8681 5321 10162 254531 8398 8399 HOST INTERACTIONS WITH INFLUENZA FACTORS%REACTOME%REACT_6323.4 Host Interactions with Influenza Factors 8106 5610 293 7040 10898 ATF4 ACTIVATES GENES%REACTOME%REACT_18355.5 ATF4 activates genes 23016 54512 5393 4801 22926 1649 4802 4800 468 167227 22894 11340 118460 51010 23404 6347 51013 3484 3576 5073 467 440 9709 8570 56915 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME%REACT_380.2 Synthesis of very long-chain fatty acyl-CoAs 23305 9524 51703 6785 79993 3293 51144 54898 2182 2181 253017 83401 2180 64834 60481 79071 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_12528.2 Regulation of pyruvate dehydrogenase (PDH) complex 5162 5163 5160 5166 5164 54704 5165 1737 1738 5467 55066 57546 1381 1382 6256 8050 ORC1 REMOVAL FROM CHROMATIN%REACTOME%REACT_1156.2 Orc1 removal from chromatin 5711 1017 5710 5714 5713 5719 23198 5925 5715 5716 5701 7311 5696 5687 1026 5695 5700 5694 5717 5718 5688 5689 1027 51343 8900 5001 4999 5000 4998 4171 5720 7316 10213 4176 5698 890 4174 4175 5699 23595 143471 990 5721 6233 84515 4173 23594 4172 81620 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 5684 5683 EUKARYOTIC TRANSLATION ELONGATION%REACTOME%REACT_1477.2 Eukaryotic Translation Elongation 6231 6232 6044 26784 100505503 26780 7311 116936 26778 116938 6228 6229 6227 6235 4736 6230 26771 6234 1917 84546 26809 25873 2197 100124516 94163 26791 26790 6233 6224 6223 6222 6203 6201 6202 23521 595100 6210 6205 6204 6208 6209 6206 6207 6217 6218 3921 6083 6165 6137 6168 6136 6138 6161 6139 6164 6160 6130 6133 9045 6132 6135 6167 101929876 6134 6169 85388 6143 6144 6141 619569 6142 6147 606500 6146 619565 619499 619562 11224 100529097 26819 26815 26817 26818 26816 6129 51121 6128 6193 6194 6192 6191 26820 6124 1915 6123 6122 6125 9349 6171 574040 6170 6173 619505 6176 100526842 6175 26811 100500804 26814 6189 6188 26795 6187 595097 595099 1936 158078 1933 1937 1938 100996747 100508408 6181 595098 6154 6155 6152 6159 8944 6157 6158 6156 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME%REACT_19193.3 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 2864 2767 2769 5330 5331 9630 2776 23236 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME%REACT_1100.5 Golgi Cisternae Pericentriolar Stack Reorganization 9133 5861 5862 891 2801 81876 8615 64689 983 26003 8548 5594 5347 NADPH REGENERATION%REACTOME%REACT_16904.1 NADPH regeneration 3417 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME%REACT_831.1 Cytochrome c-mediated apoptotic response 840 836 317 54205 842 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_756.2 RNA Polymerase III Chain Elongation 55718 51082 5440 171568 5441 9533 10623 10621 51728 10622 11128 27297 84265 55703 5437 5434 5435 101060521 661 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_169103.2 SMAD2 3 Phosphorylation Motif Mutants in Cancer 1030 1875 1874 3065 1025 1024 7048 56288 7046 60436 5045 7040 54778 9040 56937 7311 100527943 11171 142 904 51377 57154 23645 905 64750 7029 2280 4088 7316 4089 9110 9958 5590 7027 57530 5499 6233 4087 25805 23327 4609 50855 387 4221 10273 7050 6667 51592 6497 50848 5054 6498 892 4092 7323 3726 7321 5500 867 5501 7314 9612 9611 25937 8239 5933 4738 101929368 23370 5494 7514 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME%REACT_1859.2 Pentose phosphate pathway (hexose monophosphate shunt) 25796 6888 6120 5226 2539 7086 22934 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%REACT_118722.2 Pre-NOTCH Processing in the Endoplasmic Reticulum 4853 4854 56983 4855 23509 4851 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_160111.2 Ubiquinol biosynthesis 57107 10229 27235 51004 84274 51805 23590 ORGANIC CATION TRANSPORT%REACTOME%REACT_22357.1 Organic cation transport 6581 6582 6583 85413 6580 5002 55356 6584 CHROMOSOME MAINTENANCE%REACTOME%REACT_22172.2 Chromosome Maintenance 7014 8335 8334 7013 8607 54386 8337 8331 255626 3978 5111 8359 5982 5981 5983 8338 2237 8339 2491 57082 474382 8347 5426 5425 8348 8345 5424 8346 8340 5985 5984 1763 8343 8344 8341 8342 85236 8360 8362 8361 8364 54145 8363 8365 8366 8970 8368 8349 8367 5928 3013 3012 723790 8294 5931 554313 121504 3015 3014 8370 3018 3017 1058 55166 128312 8467 23421 55839 64105 79172 7015 6119 6118 6117 100847052 401541 1736 55135 10856 55651 677835 5422 5427 23649 5557 57804 5558 10714 25913 4869 26277 79682 64946 8290 54069 11339 51773 55355 65057 55320 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_11049.1 Formation of annular gap junctions 1213 1212 1759 8218 101926921 1785 1211 1601 2697 1173 INTERACTION WITH CUMULUS CELLS%REACTOME%REACT_163796.2 Interaction With Cumulus Cells 6677 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%REACT_21254.1 Presynaptic function of Kainate receptors 2785 2786 51764 2783 2784 2787 59345 2782 5330 2788 94235 2791 5331 55970 54331 2793 10681 2899 2792 23236 2790 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_121206.2 Chondroitin sulfate dermatan sulfate metabolism 135152 2239 56548 3373 79586 9469 3339 51363 126792 22856 3073 221914 3074 6383 11285 10090 10675 283464 8372 2719 727936 337876 26229 633 3425 1634 3423 27087 166012 375790 113189 411 9672 63827 6382 6385 1463 2262 50515 29940 2817 1464 55790 1462 55454 92126 10082 55501 54480 DNA DAMAGE RECOGNITION IN GG-NER%REACTOME%REACT_476.2 DNA Damage Recognition in GG-NER 7508 5887 NEUROFASCIN INTERACTIONS%REACTOME%REACT_22312.1 Neurofascin interactions 8506 6386 286 23114 1272 1641 4897 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME%REACT_22258.3 Metabolism of lipids and lipoproteins 5565 54600 5563 51422 8503 29079 6256 6604 80205 9862 90390 51003 23646 3290 80736 2 22901 3293 3283 3284 57678 5337 653365 5338 64600 5019 5443 6667 5833 57153 5346 50487 50486 242 137964 240 339221 241 22908 1387 1892 1040 126969 239 79887 79888 55090 2168 246 11145 247 340075 2167 92086 231 3248 57107 283748 5320 5322 8897 5319 8202 101928830 50814 1800 64241 728441 64240 93492 5476 5305 57104 134429 1081 81490 857 6916 1071 10229 3158 1545 1544 3339 3157 100996782 101930400 1543 6901 1559 8395 1557 1558 7004 7005 55627 7003 100500810 5407 5408 2581 4759 84246 4758 253017 114971 11343 1056 23305 3155 79993 96764 79143 9926 7296 411 51141 6382 9453 643853 51144 9468 23761 120227 23760 8800 8841 8644 57761 9412 9415 2053 10682 2638 54947 9023 9420 2629 79718 10162 8394 11283 8396 8398 8399 5034 377 27063 8871 204962 8867 1120 1119 55588 8776 376497 84649 64781 146850 9477 154141 26230 6576 51128 51129 56894 56895 255189 5901 9489 84803 127281 211 254531 622 5499 10654 3931 3930 23396 23389 55512 201164 112950 55500 2033 2678 1584 1585 151056 1586 54898 1588 9871 1589 84693 1595 6609 1591 1594 133522 1593 100652777 9439 4952 1103 30814 27124 3837 147323 3990 9443 9441 4051 9442 4048 5406 113612 79411 3992 3991 3972 2687 9440 4056 285362 4862 9524 9536 9108 2712 2717 2710 3949 6610 3073 1583 1581 3074 1580 1573 1579 4899 150763 23054 79071 1646 4018 3033 2720 3032 3030 9575 10001 788 79642 1666 9107 1645 3422 79644 1632 50640 4036 4047 81857 8720 4023 2760 23446 56994 1208 1490 85465 55224 10728 5298 5740 5294 5297 4363 84274 1582 2194 9612 7357 9611 10498 5130 8760 319 51586 10499 2657 29956 259230 51703 55331 10715 79603 8879 8877 6907 5587 27235 9218 123099 7108 340485 8613 26279 91012 253782 56848 56261 8694 8605 5291 6307 5293 6309 10558 57834 2531 9217 9517 5288 5728 8612 27242 204219 151742 5660 5287 8611 6342 81537 5290 91734 125981 55304 9261 8560 47 80339 4598 2172 6555 10400 10825 10599 570 375 213 10423 345274 8647 8681 28234 8714 5321 4597 9971 6554 23097 10802 10427 51302 162466 10998 64419 6579 116519 7179 51763 9282 54797 19 64834 892 4547 1109 9968 9969 6716 6715 6713 5500 5501 9663 6718 35 130367 33 34 1455 166929 37 5007 83401 38 10484 43 5641 80270 2819 10390 122618 6721 9619 100302263 2274 9632 29841 873 100137049 219541 4199 11010 126410 2879 2877 284541 2876 2222 2224 55326 60481 123 101927622 3295 215 10858 1384 26061 101928625 8540 10005 23417 10478 11001 427 8310 183 8309 2820 30 23600 416 415 410 414 412 5244 6095 51360 1717 1718 406 23533 6785 400569 10891 6770 129642 57704 85441 54677 84188 5264 8443 55711 3417 26119 51478 22949 1374 5465 8463 64900 336 337 2101 590 32 4594 31 1024 57733 5743 25870 91227 8029 22937 347527 5467 5469 1381 1382 1375 5468 1376 345 81693 27306 348 51805 23590 3292 344 153642 5730 64180 166785 5095 948 64174 335 5096 338 51004 8529 10554 10555 3631 285540 23179 5568 9110 23175 5289 5567 23171 5566 56624 8898 54675 5286 56623 8821 30849 55697 55300 4534 200576 9896 55361 8648 5742 4801 51099 10413 4802 253558 123745 4800 81579 80765 5296 10025 5295 6837 25937 2182 2181 2180 3638 6822 25942 3635 9572 3636 9791 NA+-DEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_19165.1 Na+-dependent glucose transporters 91749 6523 200010 6527 6526 6524 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME%REACT_18377.1 Glucagon-type ligand receptors 2785 2786 51764 2783 2784 2787 2740 2788 2791 2641 2642 55970 2778 54331 6343 2793 10681 6344 117 2792 116 2790 9340 59345 2782 2692 94235 2691 2695 2696 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_172744.2 Condensation of Prophase Chromosomes 8335 8334 653604 8337 79648 10592 5925 8331 255626 10051 128312 8358 333932 8352 8359 8353 891 8354 8338 8339 474382 8357 8356 8347 8348 29781 54892 8345 983 23310 8346 387893 8340 8343 8344 8341 8342 3021 3020 85236 8968 8360 8362 8361 8364 54145 8363 8365 8366 8970 8368 8349 8367 100616282 8351 8350 8355 5347 3013 3012 6418 723790 126961 8294 8290 554313 121504 3015 3014 8370 3018 3017 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_150266.2 Establishment of Sister Chromatid Cohesion 157570 23047 5885 114799 10735 23063 113130 9126 10274 8243 23244 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_12507.2 COPII (Coat Protein 2) Mediated Vesicle Transport 10113 9632 51128 9871 10802 10484 10427 6396 22872 BUTYRATE RESPONSE FACTOR 1 (BRF1) DESTABILIZES MRNA%REACTOME%REACT_24915.2 Butyrate Response Factor 1 (BRF1) destabilizes mRNA 23016 54512 5393 118460 207 55802 51010 23404 51013 54464 7529 677 167227 22894 56915 11340 9261 VITAMINS%REACTOME%REACT_13450.3 Vitamins 340665 120227 1592 56603 1591 1594 SHC-MEDIATED SIGNALLING%REACTOME%REACT_661.3 SHC-mediated signalling 7297 5781 5604 5605 7529 3845 53358 25759 983 3569 4893 3717 3570 3265 5594 3716 6464 6654 5595 5894 TOXICITY OF BOTULINUM TOXIN TYPE E (BONT E)%REACTOME%REACT_200616.2 Toxicity of botulinum toxin type E (BoNT E) 9900 6616 9899 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_150361.2 TRIF-mediated programmed cell death 929 23643 841 353376 7098 7099 148022 8772 11035 8737 100302736 VITAMINS B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME%REACT_25012.3 Vitamins B6 activation to pyridoxal phosphate 8566 316 55163 101928493 STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME%REACT_163734.2 STAT6-mediated induction of chemokines 6778 29110 340061 CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME%REACT_6812.3 Conjugation of salicylate with glycine 92292 54988 10249 341392 348158 219970 100287413 123876 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_25271.1 Negative regulators of RIG-I MDA5 signaling 57506 9636 7322 51191 7187 3093 9641 7311 5094 54941 7318 7323 23586 7321 100847079 7314 64135 8887 7316 84166 7128 3661 5300 1540 29110 55593 9474 79671 9140 84282 7706 83737 9246 6233 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_329.3 Inhibition of replication initiation of damaged DNA by RB1 E2F1 5422 5519 1869 5518 5515 5516 28227 7027 23649 5925 5557 5558 INTERLEUKIN-2 SIGNALING%REACTOME%REACT_27283.2 Interleukin-2 signaling 3568 7297 3558 3567 1438 3559 3560 1439 5604 5605 7529 3845 5291 5293 3569 4893 6850 3717 5296 3561 3562 3563 3265 3570 1437 6777 3716 6776 5290 6654 3718 8503 5295 5595 5781 9846 2185 5777 983 3932 5594 3635 6464 3636 5894 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_160078.2 Peptide hormone metabolism 1081 139760 590 1045 338557 1803 2922 3952 3630 6934 2864 3670 346562 2626 2695 23478 9789 90701 7252 51764 2784 2641 183 28972 5443 3479 55676 2999 3626 4311 3625 149371 10640 3624 1522 148867 10159 3623 94027 30001 9314 93659 23265 619373 2488 169026 60559 7941 2688 1363 1082 1511 94115 5080 4644 56605 5122 11336 54536 55763 5126 1359 3800 1215 5873 59272 3799 3972 55770 2028 1509 60412 1369 43 5972 1636 6844 114335 83729 290 3798 1360 6804 1361 64924 ANCHORING FIBRIL FORMATION%REACTOME%REACT_150268.2 Anchoring fibril formation 7092 3909 649 3918 1294 3914 7093 ER TO GOLGI TRANSPORT%REACTOME%REACT_11203.4 ER to Golgi Transport 10113 9632 51128 9871 10802 10484 10427 6396 22872 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME%REACT_16936.2 Prefoldin mediated transfer of substrate to CCT TriC 6950 347733 7280 81027 60 10575 10694 22948 10381 101927137 10576 7278 84790 10574 84617 908 7277 7411 10471 5202 10383 10382 5204 5201 5203 677812 7203 113457 7846 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_6871.2 APC C:Cdc20 mediated degradation of Securin 5711 996 5710 5714 5713 7324 5719 991 23198 5715 5716 9232 5701 7311 5696 5687 5695 730268 5700 5694 51433 5717 5718 5688 5689 11065 29882 246184 8697 29945 5720 7316 10213 51529 5698 5699 143471 5721 10393 6233 51434 10197 5707 5706 5709 5708 5690 5705 7321 5691 64682 5704 7314 5692 5693 5702 8881 122706 5686 5685 5682 9861 9491 5684 5683 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME%REACT_18372.1 Class B 2 (Secretin family receptors) 10203 79924 7480 7481 7482 7483 7484 6469 799 8323 2535 797 8325 8321 8322 3549 9340 8324 59345 94235 1604 2695 796 7976 2785 8326 2786 2783 51764 101929777 2784 2787 2740 2015 2788 2791 84658 2641 2642 55970 10268 133 51384 50846 2778 54331 10681 2793 6343 10266 6344 8643 10267 5746 2792 5741 117 2790 116 5744 5745 1392 1395 1394 113091 5727 2782 2692 7471 3375 7476 2691 30817 976 7855 7473 7474 7477 7478 89780 7479 2696 7472 11211 6608 54361 80326 7475 UNCOATING OF THE HIV VIRION%REACTOME%REACT_6965.4 Uncoating of the HIV Virion 5478 101060363 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_75913.2 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 330 5603 10628 329 5027 58484 10910 64170 3656 837 23118 598 7336 596 22861 3654 114548 29108 6300 10454 834 7128 64127 5608 4791 728489 842 7334 1147 7335 83737 7189 835 9447 10392 7295 8767 9051 1432 257397 351 3326 5600 8517 24145 841 1540 5970 4210 4790 6885 3551 G ALPHA (I) SIGNALLING EVENTS%REACTOME%REACT_19231.3 G alpha (i) signalling events 6002 2914 2913 2912 6000 729230 6001 3579 3577 11251 101060233 643 50839 100996758 2920 2921 8811 10636 1235 3576 10663 2918 2917 2780 2919 8862 2916 51764 5368 728458 2791 8786 8787 57007 5999 5996 56477 1132 2778 10681 1129 50838 54429 50837 50836 50840 50832 50833 50834 50835 50831 5539 5173 5179 4852 27198 338442 8843 1815 1813 1814 727 56670 718 6364 6363 8601 6366 59345 6752 6753 2841 6360 6751 6750 3827 6352 5473 151 85397 2852 5196 2785 2786 2783 5956 2784 2787 2788 1903 1901 5443 51083 55970 5733 107 108 54331 2793 109 2771 2792 2790 2770 2587 3627 4283 5726 2782 9568 283869 2550 2773 256933 10563 9294 9290 59340 11255 2779 2652 53637 4543 4544 112 115 114 94235 6010 111 113 346562 196883 1269 10803 1268 186 187 2826 2833 2832 2831 6372 6370 6374 6373 183 611 134 117579 10850 6754 6755 150 152 6387 140 9628 100996542 23596 846 57121 5030 3354 431704 53829 3350 9934 3361 64805 339403 9170 3352 259287 3351 259289 3355 259286 10287 10316 624 259285 5995 259296 221391 259291 2781 10692 259295 259293 259292 259294 259290 6288 58191 23566 2840 353164 4889 1234 4886 4887 10022 1237 1233 351 1236 5697 1232 2358 2359 301 2357 1230 50865 8698 623 10874 129521 51289 719 338398 56923 27199 64407 728 2847 5367 8484 165140 1902 4987 7852 4988 84539 4985 4986 T(4;14) TRANSLOCATIONS OF FGFR3%REACTOME%REACT_121011.2 t(4;14) translocations of FGFR3 2261 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_121139.2 Collagen biosynthesis and modifying enzymes 1306 57642 5034 10491 1301 1308 7373 85301 64175 1307 5352 5351 26577 169044 23127 136227 55214 100653071 50509 81578 1303 1300 9508 1305 9509 1302 1295 5479 1296 79709 1290 871 91522 1292 1278 8985 140766 1277 10536 5118 340267 1281 1291 1280 1288 80781 255631 1289 1310 1293 84570 1282 1298 1285 1284 7093 1297 1287 131873 1299 1286 256076 7092 649 1294 MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME%REACT_11039.1 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 2697 REGULATORY RNA PATHWAYS%REACTOME%REACT_12472.6 Regulatory RNA pathways 100302197 192670 57690 23405 5901 26523 27327 27161 54487 57510 192669 29102 8575 6895 23112 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_169385.2 Defects in vitamin and cofactor metabolism 55191 4552 1719 4548 32 4594 31 23475 9446 5743 5646 8029 5645 55229 5644 25974 55312 81034 316 53354 55163 8034 6947 10560 55034 81693 9962 3141 9963 56922 60496 60490 27010 8566 166785 23057 5095 326625 5096 101929880 440387 101928493 6948 6470 1504 51293 349565 80025 64087 4338 27249 4524 54 6573 51248 113278 80347 101928717 2694 5091 4522 119391 113235 27304 65220 80704 79178 200895 6515 6513 93100 5167 55788 8884 80308 5740 1528 79717 4363 1582 2194 1727 10135 686 64802 10243 79646 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_150353.3 Mitochondrial iron-sulfur cluster biogenesis 112812 2232 2230 2395 81894 51312 57128 IRS ACTIVATION%REACTOME%REACT_570.1 IRS activation 1796 8660 3643 3667 3630 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME%REACT_18319.3 Class C 3 (Metabotropic glutamate pheromone receptors) 846 2914 2913 2912 83756 2915 2911 259287 259289 259286 50839 259285 259296 259291 259295 259293 50838 259292 54429 50837 259294 50836 259290 50840 5726 50832 9568 50833 50834 50835 338398 2550 50831 222545 353164 2918 80835 80834 2917 2916 100996542 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_163722.2 The phototransduction cascade 801 805 808 6295 2779 10988 9397 2979 2978 5588 5158 2339 23173 2342 388531 2792 9626 5145 100529261 9187 5957 2986 2782 6010 6011 1258 5148 1259 3000 4836 5475 5578 BICARBONATE TRANSPORTERS%REACTOME%REACT_19298.1 Bicarbonate transporters 83697 57835 9497 8671 6508 6522 57282 9498 6521 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME%REACT_1046.5 Pyruvate metabolism and Citric Acid (TCA) cycle 3939 6390 6392 6391 3945 9123 6389 23539 51660 6566 682 2271 5467 728294 57546 55066 79944 8801 1381 1431 1382 4191 3420 8802 8803 137872 23530 5162 1743 5163 5160 3419 5166 3418 5164 54704 5165 1737 1738 50 4967 3421 6256 25874 8050 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_13643.2 NRIF signals cell death from the nucleus 55851 4804 7314 4803 5664 7316 7311 83464 51107 8878 5599 23385 6233 7189 23421 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_22336.1 Presynaptic nicotinic acetylcholine receptors 1144 1135 1134 1143 1136 1146 1145 1141 1137 1142 1138 8973 ASSEMBLY OF THE HIV VIRION%REACTOME%REACT_6818.8 Assembly Of The HIV Virion 5478 7251 79720 7314 137492 5045 7316 7311 9397 155382 55048 101060363 51160 6233 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_1128.2 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 5111 2237 6996 57804 4913 4968 5425 8930 10309 4350 5424 3978 23583 10714 5423 328 4595 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME%REACT_23826.2 Passive transport by Aquaporins 363 4284 364 366 101930168 89872 360 343 361 100509620 282679 362 358 359 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME%REACT_18356.4 Unfolded Protein Response (UPR) 54512 5393 1965 167227 22894 9114 100137049 2931 2137 118460 23404 9451 6347 10106 10525 9820 55033 4189 3484 8681 30827 3576 467 55062 440 9709 9570 7466 101928061 8570 445329 2081 55738 7094 3068 6464 1639 1200 23016 7184 101929857 4801 22926 1649 3309 8720 4802 100500842 4800 22872 468 64061 51726 811 56005 9797 5611 1663 2673 118 11015 7709 51360 58477 4000 6745 27230 10954 116138 11340 10897 10130 51010 5526 51013 9695 10113 6818 5073 37 84447 56915 6734 TELOMERE MAINTENANCE%REACTOME%REACT_7970.4 Telomere Maintenance 8335 7014 8334 8607 7013 54386 8337 8331 255626 3978 128312 5111 8359 5982 5981 5983 2237 8338 8339 7015 6119 474382 6118 6117 8347 5426 5425 8348 100847052 8345 5424 8346 8340 1736 5985 5984 1763 8343 55135 8344 10856 8341 55651 677835 8342 5422 85236 5427 8360 8362 23649 8361 5557 8364 54145 57804 8363 5558 8365 8366 8970 8368 8349 8367 10714 25913 3013 3012 26277 723790 8294 8290 554313 121504 3015 3014 8370 65057 3018 3017 EUKARYOTIC TRANSLATION INITIATION%REACTOME%REACT_2159.5 Eukaryotic Translation Initiation 6231 6232 6044 26784 26781 100505503 26780 6043 7311 116936 26778 116938 6228 6229 6227 6235 4736 6230 26771 6234 84546 26809 25873 2197 100124516 3646 8669 94163 26791 26790 6233 8668 101060318 677847 6224 6223 6222 6203 6201 6202 23521 1981 595100 6210 6205 6204 6208 6209 6206 6207 6217 6218 3921 6083 6165 6137 6168 6136 6138 6161 6139 6164 6160 8894 1965 8893 6130 6133 9045 6132 6135 101929876 6167 6134 6169 85388 6143 6144 1967 6141 6142 619567 1964 1968 6147 619568 8890 606500 8891 8892 6146 619565 619499 619562 9669 7458 100302143 1978 100529097 1974 11224 1973 1977 26819 1975 26815 1983 26817 26818 26816 6129 51121 6128 6193 6194 6192 6191 26820 652965 6124 6123 652966 6122 6125 9349 6171 574040 6170 619505 6173 8663 100526842 8661 6176 8662 6175 26811 8666 8667 8665 26814 6189 6188 8664 26795 6187 595097 27335 595099 100996747 100508408 6181 595098 6154 6155 26986 6152 6159 8944 6157 6158 6156 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_22186.3 Deposition of new CENPA-containing nucleosomes at the centromere 8335 1058 8334 8607 8337 8331 255626 55166 128312 8467 23421 55839 8359 64105 79172 8338 2491 8339 57082 474382 8347 8348 8345 401541 8346 8340 8343 8344 8341 8342 85236 8360 8362 8361 8364 54145 8363 8365 8366 8970 8368 8349 8367 5928 3013 3012 4869 723790 79682 8294 64946 54069 5931 11339 554313 51773 121504 3015 3014 55355 8370 55320 3018 3017 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_13415.1 p75NTR recruits signalling complexes 4804 3654 7314 8767 4615 4803 7316 7311 8878 5584 3551 6233 7189 REGULATION BY TREX1%REACTOME%REACT_163652.2 Regulation by TREX1 11277 84126 PHOSPHORYLATION SITE MUTANTS OF CTNNB1 ARE NOT TARGETED TO THE PROTEASOME BY THE DESTRUCTION COMPLEX%REACTOME%REACT_228229.1 phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex 5711 5710 5714 5713 1452 5719 3065 8945 2932 7089 23198 139285 7088 6500 5715 5716 1499 5701 7311 5696 5687 5695 5700 166 5694 6932 6934 5717 5718 5688 5689 8454 8312 5720 7316 10213 324 5698 83439 9978 5699 7090 7091 10023 143471 5721 6233 5519 5518 5515 5516 5529 1487 5528 1488 5527 23401 10197 5707 5525 5706 5709 5708 5690 5705 5691 5704 5526 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 51176 5684 5683 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_9029.2 Cyclin A:Cdk2-associated events at S phase entry 5711 1017 5710 5714 5713 1022 5719 9134 898 5925 6500 902 5715 5716 5701 7311 5696 5687 1026 5695 5700 1163 5694 5717 5718 5688 5689 1027 8454 51343 8900 6502 7465 4331 5720 7316 10213 5698 890 5699 4149 993 5721 994 6233 4609 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 5686 5685 5682 9861 9491 5684 5683 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_1845.4 Formation of RNA Pol II elongation complex 728340 1022 2968 2967 1025 5438 100126332 5439 5436 902 5437 5434 5435 8178 5431 5433 904 5430 905 5432 22916 2962 6749 2963 7469 5440 6829 100302242 25920 5441 11198 4331 4686 6827 7936 2068 9150 2071 6921 6924 6917 6923 2965 51497 2966 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME%REACT_25024.2 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation 5604 5605 7311 3569 3570 54106 9261 3656 23118 51295 7336 1845 5781 1848 3654 51284 1849 6288 466 1846 2353 10454 100996792 7316 246330 64127 5608 7867 983 6285 4791 5598 177 5599 1660 7334 7335 1147 51311 6283 6233 7189 5606 9252 7297 4214 1385 5601 57161 5602 10392 1386 51135 57162 3146 2002 8767 1432 4615 257397 5519 3725 6416 5518 4205 351 5515 5516 4208 3717 3716 5595 5600 5528 8517 6195 6197 7314 6196 5970 4792 5594 4793 5609 4790 6885 3551 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_12389.2 eNOS activation and regulation 801 5593 805 808 857 1719 207 3320 6697 5805 2643 8976 2644 115677 4846 51070 1785 10434 340481 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_116105.3 Glycosphingolipid metabolism 653365 55512 57733 25870 411 427 2717 347527 6610 643853 416 415 3073 2760 410 414 3074 412 5660 6609 339221 64781 153642 55627 22901 2720 340075 10825 7357 57704 2629 2581 79642 56624 4759 4758 79411 101927622 285362 5476 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME%REACT_13565.2 Regulation of ornithine decarboxylase (ODC) 5711 5710 5714 5713 5719 23198 5715 5716 5701 5696 5687 5695 5700 5694 5717 5718 5688 5689 4946 4947 5720 10213 5698 4953 5699 51582 143471 5721 51686 1728 10197 5707 5706 5709 5708 5690 5705 5691 5704 5692 5693 5702 122706 5686 5685 5682 9861 9491 5684 5683 DIGESTION OF DIETARY LIPID%REACTOME%REACT_9518.2 Digestion of dietary lipid 5406 1056 5407 1208 5408 SIGNALING BY ACTIVIN%REACTOME%REACT_150238.2 Signaling by Activin 3625 130399 3624 91 10468 4088 10272 4089 10589 93 92 8928 4087 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_8017.1 APC-Cdc20 mediated degradation of Nek2A 51434 11065 996 7324 9184 991 29882 7321 64682 246184 8697 7314 29945 4085 8881 7316 7311 51529 730268 4751 51433 701 10393 6233 2-LTR CIRCLE FORMATION%REACTOME%REACT_9058.3 2-LTR circle formation 3981 7520 2547 3159 11168 7518 8815 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_21285.1 Regulation of AMPK activity via LKB1 51719 81617 6794 5565 5564 5563 5562 92335 5571 55437 5494 51422 57521 53632 UPTAKE AND ACTIONS OF BACTERIAL TOXINS%REACTOME%REACT_228211.1 Uptake and actions of bacterial toxins 801 805 808 9900 6616 10015 22987 6843 5604 5045 5605 112755 6416 127833 9899 5609 6844 6804 6857 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME%REACT_13567.2 Cytochrome P450 - arranged by substrate type 340665 6916 64816 1545 1544 1548 1551 1583 1581 57834 1580 1543 1576 1549 1573 1579 1559 1565 1577 1555 1553 1557 1558 66002 100861540 126410 8529 284541 9971 6256 56603 51302 10858 8648 5443 1584 1585 1586 1588 120227 1589 1595 1592 1591 29785 1594 54905 1593 1562 1572 101929829 1571 5740 1582 9420 4051 113612 11283 10499 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%REACT_147707.2 Metabolism of Angiotensinogen to Angiotensins 2999 4311 1522 10159 1511 183 1359 1215 59272 2028 1509 5972 1636 290 1360 1361 BIOLOGICAL OXIDATIONS%REACTOME%REACT_13433.2 Biological oxidations 54988 340665 6916 2729 54576 191 54490 54600 1545 54579 1544 7358 54577 54578 574537 101929773 1548 1551 54498 1583 1581 1543 1580 1549 1576 1573 1579 1559 1565 1577 1555 1553 1557 2730 1558 66002 6799 246181 100861540 126410 130 131 284541 100616124 10249 124 445329 6256 127 125 126 10858 116285 347734 27284 79017 120227 27430 29785 54905 10861 1562 1572 6783 1571 5740 1582 9420 7365 7360 10720 23169 7367 1312 54657 7363 7364 4128 4837 54659 7366 10941 341392 54658 11283 100287413 1836 55902 10499 4552 4548 8574 64816 95 9446 348158 91227 25830 57834 27233 27306 64180 124975 2954 64174 2952 2953 2947 8529 2948 2941 2944 84532 4143 2940 22977 4144 4258 92292 217 216 9971 2950 101928916 91703 56603 119391 4259 51302 4257 196743 2326 2679 55748 8648 101929857 2328 2327 5742 7172 10380 2678 5443 123876 1584 2946 1585 9 1586 2949 26873 221357 1588 1589 10 1595 1592 1591 1594 4129 51000 1593 653689 101929829 9060 2938 2939 219970 92086 6819 2937 6817 4051 6818 113612 9061 2686 1800 6822 2687 728441 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME%REACT_22228.1 Role of second messengers in netrin-1 signaling 5306 1630 5335 57113 7223 7224 7220 9423 7225 7222 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_75918.1 Inwardly rectifying K+ channels 2785 2786 2783 3760 3761 2784 2787 2788 100996843 3759 55970 10060 54331 2793 2792 2790 3768 3766 3770 100134444 3763 3765 3758 6833 2782 94235 3772 3773 9568 3764 3762 2550 3767 C-SRC MEDIATED REGULATION OF CX43 FUNCTION AND CLOSURE OF GAP JUNCTIONS%REACTOME%REACT_11043.2 c-src mediated regulation of Cx43 function and closure of gap junctions 7082 2697 TRANSLATION%REACTOME%REACT_1014.4 Translation 6231 6232 6044 100505503 6043 116936 116938 6228 6229 6227 4736 6235 6230 6234 1917 84546 2197 23478 23471 3646 9789 90701 1650 8669 8668 677847 6224 6223 6222 6203 6201 6202 1981 6210 6205 6204 6208 6209 6206 6207 6217 6218 3921 6137 6136 6138 6139 6130 6133 6132 6135 6134 6143 6144 6141 6142 6147 606500 6146 9669 1978 1974 11224 1973 1977 1975 1983 6129 6128 6124 6726 6123 6122 6729 6728 6125 6727 574040 619505 6176 6175 100500804 55176 26795 27335 158078 6731 26986 6730 6734 26784 26781 26780 7311 26778 26771 26809 25873 100124516 94163 26791 26790 6233 101060318 28972 23521 58477 6745 595100 6748 6746 6747 6083 6165 6168 6161 6164 2107 6160 8894 1965 8893 9045 6167 101929876 6169 85388 1967 619569 619567 1968 1964 619568 8890 8891 10952 8892 619565 619499 619562 7458 100302143 100529097 26819 26815 26817 26818 26816 51121 6193 6194 6192 6191 26820 652965 23480 1915 652966 9349 6171 6170 6173 8663 100526842 8661 8662 26811 8666 8667 8665 26814 6189 6188 8664 6185 29927 6187 595097 595099 1936 60559 1933 1937 1938 100996747 100508408 6181 6184 595098 23708 6154 6155 6152 6159 8944 6157 6158 6156 GLYCOPROTEIN HORMONES%REACTOME%REACT_15398.1 Glycoprotein hormones 1081 3626 3625 3624 3623 94027 93659 2488 1082 94115 3972 114335 83729 7252 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_169185.3 DNA Damage Telomere Stress Induced Senescence 8091 1017 3009 8335 7014 3007 8334 7013 3008 25842 3024 54386 8337 9134 898 7290 23523 5925 8331 57634 3005 3006 255626 29855 4001 1026 4361 128312 4683 1027 8359 8900 8338 8339 474382 8347 8348 8345 890 8346 8340 8343 8344 8341 8342 85236 8360 3159 8362 8361 8364 54145 8363 7157 8365 8366 8970 8368 8349 8367 25913 3013 3012 26277 723790 10111 8294 8290 554313 121504 472 3015 3014 8370 65057 3018 3017 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY DVL-INTERACTING PROTEINS%REACTOME%REACT_228242.1 negative regulation of TCF-dependent signaling by DVL-interacting proteins 1857 1856 440193 1855 80319 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_11208.2 Golgi to ER Retrograde Transport 9276 1315 375 8729 22818 11316 22820 1314 372 100500810 55738 BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME%REACT_13472.1 Breakdown of the nuclear lamina 4001 839 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME%REACT_22339.1 RNA Polymerase III Abortive And Retractive Initiation 4782 4784 55814 6621 4774 9330 27297 5437 84265 5434 5435 101928686 101060521 661 7702 6619 55718 51082 9328 9329 5440 171568 5441 5451 10623 9533 6741 10621 51728 10622 11128 10302 55703 55290 2972 2976 6908 2971 2975 4781 6617 6618 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME%REACT_17025.4 Downstream signal transduction 6199 3815 2932 5581 23035 5582 572 5604 5605 2064 4690 1950 1026 5921 1398 3265 145957 6777 2931 1027 8503 1956 2309 5156 6778 8660 112 5335 115 114 7409 5137 111 2069 113 26523 196883 5155 814 7249 5580 983 2475 1839 3932 23239 842 1147 50852 5894 5578 801 253260 156 805 7297 808 1385 940 3084 685 942 941 3708 3709 3845 84335 64223 4893 26281 101060747 3717 10818 4193 9542 930 5170 5159 5153 23112 57761 10718 5595 2247 2246 2249 2255 8823 27006 2251 2252 2254 2248 8817 8074 5594 2889 1399 8440 9564 2549 5291 5293 27161 3569 3667 2534 5728 3570 117145 79109 5290 4343 6772 6774 5781 5577 5136 5576 5573 5568 5567 3164 5566 3710 5575 152831 2264 9965 57690 7529 107 5296 108 192669 109 3716 6776 6654 5295 10000 192670 207 208 2308 27327 2886 SNRNP ASSEMBLY%REACTOME%REACT_11066.1 snRNP Assembly 6606 51808 9631 96764 11218 53371 10762 6607 4927 6628 10419 5903 8086 8021 55746 129401 7175 9883 6634 6633 6635 1207 6636 79084 8480 22916 6637 10073 9688 4686 79760 23225 25929 79833 50628 23165 9972 11097 57122 6632 23279 8487 79902 23511 79023 23636 348995 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_147851.3 Arachidonic acid metabolism 6916 9536 5743 1545 91227 1544 57834 1580 1543 873 1573 1579 1559 27306 1557 9261 1558 5730 64180 64174 126410 8529 2879 2877 284541 2876 127281 5321 5742 2678 8644 242 240 241 239 246 2053 247 10728 5740 4363 1582 92086 3248 4051 4048 113612 101928830 1800 22949 2687 11283 728441 4056 CLOSTRIDIUM NEUROTOXICITY%REACTOME%REACT_11184.3 Clostridium neurotoxicity 112755 9900 6616 127833 9899 22987 6843 6844 6857 6804 NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION%REACTOME%REACT_11103.2 Nef mediated downregulation of MHC class I complex cell surface expression 8907 8905 567 164 1174 162 3105 10053 130340 55690 TCF7L2 MUTANTS DON'T BIND CTBP%REACTOME%REACT_228223.1 TCF7L2 mutants don't bind CTBP 5711 5710 5714 5713 1452 5719 3065 8945 2932 7089 23198 139285 7088 6500 5715 5716 1499 5701 7311 5696 5687 5695 5700 166 5694 6932 6934 5717 5718 5688 5689 8454 8312 5720 7316 10213 324 5698 83439 9978 5699 7090 7091 10023 143471 5721 6233 5519 5518 5515 5516 5529 1487 5528 1488 5527 23401 10197 5707 5525 5706 5709 5708 5690 5705 5691 5704 5526 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 51176 5684 5683 ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME%REACT_16970.1 Electric Transmission Across Gap Junctions 10052 56666 24145 84694 57369 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_1941.3 Formation of transcription-coupled NER (TC-NER) repair complex 728340 1022 2968 2967 5438 5439 5436 56949 902 2067 1161 5437 5434 5435 5431 5433 5430 5432 5440 5441 4331 2068 2074 2071 2073 6917 2072 2965 2966 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME%REACT_13477.2 Transmission across Chemical Synapses 6616 777 773 6857 784 785 782 783 1144 55584 51764 2897 2898 80852 88 1146 1145 27092 2791 816 817 818 10142 101929306 100507353 23426 815 2892 1135 2891 5923 2905 1134 1136 2906 57030 1137 2901 2744 10681 1139 2903 2752 2893 2899 1138 8973 6237 83988 10369 10368 1741 5579 1742 1143 6195 1141 1142 6197 4646 2900 6196 2890 4747 9463 2036 60482 84254 27165 1739 89832 4905 160 59345 27330 101930324 59283 2785 2786 2783 3760 3761 2784 2787 5330 2788 2560 2561 2562 2569 5331 2567 2566 100996843 200959 2557 2554 6582 2556 3759 55970 2559 107 2558 6580 108 54331 2793 109 2771 2792 2790 2770 3768 3766 100134444 3763 3765 2782 3772 6539 9568 6538 3762 2774 2550 2555 55879 2773 43 6844 6804 5582 2902 2904 3265 9254 112 115 114 94235 3773 111 113 346562 23229 196883 814 2570 23236 5894 5578 801 805 808 1385 18 7915 101060747 4193 5170 673 1312 6531 4128 5594 85390 590 85389 9495 6505 6506 80331 6512 6572 2572 2571 5568 5567 6571 217 5566 54407 81539 774 55799 6529 8541 8499 9256 6540 8224 3312 5924 22999 8497 6511 10497 6507 6853 6854 5864 8500 10815 140679 1103 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_162.5 Elevation of cytosolic Ca2+ levels 3710 6786 57113 84876 5023 3708 7225 3709 7222 BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME%REACT_419.3 Beta oxidation of butanoyl-CoA to acetyl-CoA 1892 35 3033 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_21346.1 Activation of Ca-permeable Kainate Receptor 801 83988 805 808 2897 2898 1741 1742 2901 2900 1739 2899 THE NLRP3 INFLAMMASOME%REACTOME%REACT_75808.1 The NLRP3 inflammasome 5027 10910 10628 351 114548 3326 29108 24145 4210 7295 834 9051 SIGNALING BY NOTCH3%REACTOME%REACT_118862.2 Signaling by NOTCH3 5664 3714 55851 4854 83464 51107 182 102 54567 28514 23385 STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME%REACT_13438.3 Sterols are 12-hydroxylated by CYP8B1 5740 1582 G2 M CHECKPOINTS%REACTOME%REACT_828.2 G2 M Checkpoints 9133 1017 84515 4173 23594 4172 8318 1111 995 144715 55388 8317 5884 10926 5883 5982 63967 3364 9088 891 5983 5001 4999 5000 7465 6119 4998 6118 6117 84126 545 4171 4176 983 4174 472 4175 5985 5984 23595 990 993 5810 ACTIVATION OF PKB%REACTOME%REACT_790.1 Activation of PKB 101060747 208 117145 5170 57761 CRNA SYNTHESIS%REACTOME%REACT_9527.2 cRNA Synthesis EUKARYOTIC TRANSLATION TERMINATION%REACTOME%REACT_1986.3 Eukaryotic Translation Termination 6231 6232 6044 26784 100505503 26780 7311 116936 116938 26778 6228 6229 6227 6235 4736 6230 26771 6234 84546 26809 25873 2197 100124516 94163 26791 26790 6233 6224 6223 6222 6203 6201 6202 23521 595100 6210 6205 6204 6208 6209 6206 6207 6217 6218 3921 6083 6165 6168 6137 6136 6161 6138 6164 2107 6139 6160 6130 6133 9045 6132 6135 6167 101929876 6134 6169 85388 6143 6144 6141 6142 6147 606500 6146 619565 619499 619562 11224 100529097 26819 26815 26817 26818 26816 6129 51121 6128 6193 6194 6192 6191 26820 6124 6123 6122 6125 9349 6171 574040 6170 6173 619505 6176 100526842 6175 26811 26814 6189 6188 26795 6187 595097 595099 100996747 100508408 6181 595098 23708 6154 6155 6152 6159 8944 6157 6158 6156 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_200753.2 formation of the beta-catenin:TCF transactivating complex 8335 8313 8334 8607 653604 3065 8337 7089 7088 8331 255626 1499 123169 607 128312 6932 6934 8358 333932 8352 8359 8353 8354 8338 8339 79577 7015 26108 474382 8357 8356 8347 8348 8345 83439 90780 8346 8340 7090 7091 8343 8344 8341 8342 3021 4609 3020 85236 8968 8360 8362 8361 4221 8364 10524 2033 283149 54145 8363 8295 8365 8366 8970 8368 8349 8085 8367 100616282 8351 8350 6597 8355 3013 1387 3012 5929 723790 126961 8294 9070 8290 554313 121504 3015 3014 8370 3018 51176 3017 ATTENUATION PHASE%REACTOME%REACT_200624.2 Attenuation phase 1387 3303 3305 3281 85390 3337 2288 10728 3297 3320 2033 3312 85389 3326 3304 3306 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME%REACT_22387.2 Synthesis of substrates in N-glycan biosythesis 27090 10402 54187 64841 55808 5372 5373 4351 57171 9945 2720 29906 10825 55907 8869 10610 79947 81849 22845 30815 54344 6675 129807 84620 4759 386724 4758 10020 4597 79644 140838 8813 29925 29926 6489 80896 5238 8128 7903 26503 338596 643853 10559 2673 51046 29880 6480 8818 256435 6482 6483 6487 6484 5476 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%REACT_13523.4 Vitamin D (calciferol) metabolism 4036 120227 2638 8029 1591 5641 1594 COX REACTIONS%REACTOME%REACT_1396.4 COX reactions 5742 HEXOSE UPTAKE%REACTOME%REACT_9441.2 Hexose uptake 3099 3098 9631 53371 2542 2646 10762 4927 92579 6527 5903 8086 55746 8021 129401 7175 9883 2538 8480 6515 6513 200010 3101 6517 6514 9688 57818 23225 2645 23165 9972 6523 11097 57122 6526 6524 23279 79902 6518 23511 79023 23636 348995 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME%REACT_1851.5 RNA Polymerase II Transcription Initiation 728340 6877 51616 1022 2968 6881 2967 6878 5438 6875 5439 5436 6880 902 6883 6884 6882 5437 5434 5435 2957 5431 2959 2958 5433 5430 5432 6872 6874 2960 2961 2962 2963 5440 5441 6873 138474 4331 2068 102157402 2071 83860 6908 2965 2966 GPCR LIGAND BINDING%REACTOME%REACT_21340.5 GPCR ligand binding 2914 2913 2912 83756 729230 50839 6019 9340 2532 8324 5734 5732 2920 2921 1235 2918 7976 3640 2917 2919 2916 5368 50838 50837 50836 50840 50832 50833 50834 50835 50831 976 1815 1816 1813 1814 1812 338557 2922 727 56670 718 51052 6364 6363 6361 6366 6367 6752 6753 1604 2841 6360 6751 6750 155 6348 6349 3827 151306 6351 6352 153 154 80835 80834 6356 151 2852 2853 5196 6354 2147 5443 51083 5733 5746 5741 5744 5745 1392 1395 1394 5727 4283 5729 5726 283869 134860 414062 134864 256933 11211 10563 9294 1081 9290 9283 553 5020 552 2652 3549 53637 4158 4543 4544 4160 4161 4157 4159 1269 10803 27202 1268 186 187 101929777 2826 2834 2833 2832 2831 6372 6370 2641 6374 2642 6373 6376 136 133 611 51384 134 3062 117579 8643 10850 6754 6755 6387 140 2863 7471 2861 7476 7473 9288 7474 7477 7478 7479 9287 7472 7475 100996542 5028 9002 846 1241 57121 3814 1133 5030 84109 27334 2846 2915 53829 2911 9934 339403 60675 64805 84432 5029 84634 10161 9170 2796 128674 185 259287 2828 2829 259289 259286 10886 799 797 10316 624 83551 10800 259285 2798 259296 2797 259291 23620 10887 259295 2867 259293 259292 6863 2865 8477 259294 6915 259290 347148 3061 257313 23566 58191 2693 5724 2862 3060 57105 387129 29933 146 147 5031 148 5032 2840 2925 64106 353164 594857 6846 4889 1234 4886 8620 4887 7252 680 10022 2150 886 885 6865 6866 6869 6870 2149 5731 5737 1237 1238 1233 1236 5697 1232 6343 6344 1230 8698 6375 56413 623 10874 129521 2837 1128 5021 51289 7201 7200 719 1131 1910 338398 56923 27199 728 1908 2847 319100 10911 7855 1906 5367 1907 8484 1909 165140 222545 8111 1902 4295 4828 54361 4829 3972 4922 114814 80326 4987 887 4988 7852 84539 4985 2151 4986 4923 10203 79924 3579 3577 11251 101060233 643 2535 9034 9038 100996758 6347 1524 796 8811 3576 10663 59350 8862 8326 51764 2740 2015 84658 2791 728458 57007 56477 50846 1132 2778 10681 1129 54429 2488 2692 2691 30817 5539 5173 5179 4852 27198 338442 8843 2696 6608 7480 7481 7482 7483 7484 8323 8325 5660 8321 8322 59345 5739 5473 2785 2786 2783 5956 2784 2787 2788 1903 122042 1901 55970 10268 51554 54331 2793 10266 10267 135 2792 117 2790 116 2587 113091 3627 2782 9568 2550 89780 59340 3274 11255 3269 2864 94235 6010 2695 183 150 152 3973 2492 7253 23596 3354 3358 3357 3350 3360 3361 3362 3363 3352 3356 6469 3351 3355 5995 221391 94233 10692 6288 551 554 351 2358 2359 301 2357 50865 3375 SIGNALING BY FGFR2 AMPLIFICATION MUTANTS%REACTOME%REACT_121255.2 Signaling by FGFR2 amplification mutants 2263 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_172638.2 Asymmetric localization of PCP proteins 5711 5710 5714 5713 5719 23198 5715 5716 5701 7311 5696 5687 5695 5700 5694 2535 8325 8321 5717 8322 5718 5688 57154 5689 64750 1856 8324 144165 23513 5720 7316 10213 5698 5699 7976 57216 143471 5721 6233 50855 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 7855 7474 122706 5686 5685 5682 9861 9491 5684 5683 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_1665.4 Glucagon signaling in metabolic regulation 2785 2786 51764 2783 2784 2787 2788 2791 2641 2642 55970 107 108 2778 54331 109 2790 112 115 59345 114 2782 94235 111 5577 113 196883 5576 5573 5568 5567 5566 5575 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME%REACT_22161.4 Post-translational protein modification 10331 1984 83475 1725 8858 56648 2621 2677 79001 2720 79642 79644 1650 5589 338596 11320 25834 10559 2673 8702 8704 8703 9331 4249 51046 29880 11282 6480 9334 6482 6483 6487 6484 4582 79623 4586 51301 170689 118430 192134 27090 283463 10417 157869 10418 2589 80267 171019 55757 5045 2590 56886 2591 55741 644378 7058 9037 10071 11226 168391 55901 7057 92949 442117 9510 11227 26290 9508 9509 140687 9245 100528030 170691 5624 170692 84002 23275 22901 50614 374907 63917 2650 11095 10825 10610 11096 11093 56913 374378 4589 80731 56999 4588 140766 79695 200958 4597 64409 117248 57876 2158 10802 145173 2155 2159 114805 4584 5627 6396 10427 4583 4585 51809 8128 2147 7903 29071 8693 54437 81794 9507 256435 80070 221981 81792 55568 9719 340075 727897 57452 7329 11173 84752 11174 56667 2683 146712 79875 5199 54507 101928934 100996396 339366 10484 23145 394263 5476 143662 57188 9632 10678 4759 4758 79369 411 821 643853 416 415 410 414 412 51227 84720 55650 9487 8818 5281 23556 100130872 93183 94025 284098 170690 54872 140453 5279 5283 5277 54965 11253 9695 9488 25870 10402 347527 93010 79087 59343 7341 440138 153642 54187 64841 5329 10054 55808 6613 79868 6612 5372 7841 5373 205564 51128 4351 8733 7991 10055 57171 128869 101929087 9945 144245 29906 199857 55907 1798 8869 29843 79947 1603 81849 3703 22845 29929 84061 30815 54344 23193 6675 84920 80055 129807 51604 84620 386724 91869 10020 100507589 140838 79796 8813 94005 79053 85365 9526 29925 2923 10026 29926 9761 6489 80896 10195 56052 5238 4248 3998 26503 22872 811 9871 6185 6184 4247 57134 10113 10905 90411 79694 4122 4121 4124 2530 4245 285362 SIGNALING BY WNT IN CANCER%REACTOME%REACT_228331.1 Signaling by WNT in cancer 8335 8334 54894 653604 3065 8337 8331 255626 51699 123169 2535 1857 8358 333932 1856 8352 8359 8353 8354 8338 8339 474382 1855 8357 8356 8347 80351 8348 9559 8345 8346 8340 11197 6259 9101 8343 8344 8341 8342 3021 4609 3020 4040 85236 56998 8968 8360 8362 9736 8361 4221 8364 54145 283149 8363 8295 8365 8366 5519 8970 8368 5518 8349 83999 8367 5515 8085 100616282 5516 8351 8350 4041 8355 5529 3013 5528 3012 5527 5525 8452 723790 126961 5526 8294 554313 121504 3015 3014 8370 84870 3018 3017 8313 55366 59352 340419 7480 7481 7482 7483 7484 607 128312 8323 8325 8321 8322 59349 50999 7015 26108 22943 440193 8549 27123 10524 27121 6422 5534 7534 6423 1387 5530 5532 9070 8290 89780 1455 55737 7514 5711 5710 5714 857 5713 8607 1452 5719 8945 2932 7089 23198 139285 7088 6500 5715 5716 1499 5701 7311 5696 5687 5695 5700 166 5694 6932 6934 5717 5718 8395 5688 5689 8454 8312 64750 79971 79577 5720 7316 10213 324 5698 83439 9978 5699 7090 7091 10023 143471 5721 6233 801 805 808 101929777 343637 51384 6597 1487 1488 23401 10197 50964 5707 5929 5706 5709 5708 5690 7471 5705 5691 7476 5704 7314 5692 5693 5702 7473 7474 7477 122706 7478 7479 7472 5686 5685 5682 9861 9491 7475 51176 5684 5683 23072 84133 331 284654 25776 8724 57680 8658 81029 90780 51339 2033 1454 4775 1459 1457 81847 64840 4773 4772 207 208 1460 7855 79412 54361 80326 80319 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_11065.1 Beta-catenin phosphorylation cascade 5529 5528 23401 5527 1452 5525 2932 139285 5526 5519 324 5518 5515 5516 10023 8312 AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME%REACT_13655.1 AKT-mediated inactivation of FOXO1A 10000 207 208 2308 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME%REACT_97.2 Recruitment of repair and signaling proteins to double-strand breaks 672 4361 7158 472 9656 4683 3014 10111 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_169132.2 Defective CUBN causes hereditary megaloblastic anemia 1 55191 4552 1719 4548 32 4594 31 23475 9446 5743 5646 8029 5645 55229 5644 25974 55312 81034 316 53354 55163 8034 6947 10560 55034 81693 9962 3141 9963 56922 60496 60490 27010 8566 166785 23057 5095 326625 5096 101929880 440387 101928493 6948 6470 1504 51293 349565 80025 64087 4338 27249 4524 54 6573 51248 113278 80347 101928717 2694 5091 4522 119391 113235 27304 65220 80704 79178 200895 6515 6513 93100 5167 55788 8884 80308 5740 1528 79717 4363 1582 2194 1727 10135 686 64802 10243 79646 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME%REACT_12077.2 Signalling to p38 via RIT and RIN 7297 6014 5781 673 6016 5604 5605 4803 7529 3845 983 3569 4893 3717 4914 3265 3570 5594 3716 5595 5894 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_120815.3 Regulation of Hypoxia-inducible Factor (HIF) by oxygen 7322 3091 2033 7311 55662 1387 2034 7422 7323 7428 405 54583 2056 112398 8453 64344 112399 7321 768 7314 7316 6921 6923 9978 6233 GAB1 SIGNALOSOME%REACTOME%REACT_12578.4 GAB1 signalosome 6199 3815 2932 23035 572 2064 2549 1950 5291 5293 1026 27161 3667 2534 5728 117145 145957 79109 2931 5290 1027 4343 8503 1956 2309 5156 8660 5781 7409 2069 26523 5155 7249 3164 2475 1839 3932 23239 842 1147 50852 152831 253260 2264 9965 1385 940 55824 3084 685 57690 942 941 84335 64223 26281 101060747 10818 5296 4193 9542 192669 930 5170 5159 23112 57761 10718 5295 10000 2247 2246 192670 2249 2255 8823 207 27006 208 2251 2252 2254 2308 2248 8817 8074 27327 1445 5829 CLEARANCE OF NUCLEAR ENVELOPE MEMBRANES FROM CHROMATIN%REACTOME%REACT_160251.2 Clearance of Nuclear Envelope Membranes from Chromatin 221496 2010 23592 7443 8815 SUMOYLATION%REACTOME%REACT_163823.2 SUMOylation 7341 10054 6613 6612 205564 10055 101929087 29843 59343 7329 ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_1650.3 Activation of BIM and translocation to mitochondria 10018 5599 8655 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_172633.3 Chromatin modifying enzymes 3066 8335 8334 653604 3065 1019 8337 8331 57634 255626 8358 333932 8352 8359 8353 8354 8338 8339 474382 9575 8357 8356 8347 57459 8348 8345 8346 8340 57504 8343 8344 8341 8342 6604 85236 8968 8360 8362 8361 8364 8363 8295 8365 8366 8970 8368 8349 8367 5928 8351 9112 8350 8355 3013 3012 54815 723790 126961 8294 9612 9611 102157402 10498 5931 8850 554313 121504 9219 3015 3014 8370 3018 3017 53615 6907 1108 1107 2648 128312 595 6871 10524 27097 1387 23028 10933 23522 56970 85235 9767 79960 55929 10943 54934 101929776 55167 100303755 23587 6944 23326 10629 51230 9913 26009 9643 11143 1810 10474 92815 10362 339287 84148 221613 317772 51562 84289 11091 26610 93624 54556 284058 8607 60 55683 55689 23338 8969 86 3054 6314 10445 54859 8464 80314 7994 23774 55250 55257 56943 112869 8518 440689 57325 55578 27154 64769 8329 8089 10902 8520 117143 8332 55140 8330 8473 51147 8336 7862 23186 51317 6881 6880 6883 3717 8841 6597 79084 79718 51742 8819 10856 55170 196528 22992 55193 55818 221656 51412 23081 8284 9682 1386 5978 55693 79685 25855 2033 8289 55869 10419 64426 1788 83933 10284 54496 23135 84678 6603 79595 23133 6601 6602 5253 6605 8242 80853 51780 6595 23030 6599 6598 57492 5926 5927 10765 2874 84159 55352 3276 7403 ACETYLATION%REACTOME%REACT_6732.3 Acetylation 9 10 ABNORMAL METABOLISM IN PHENYLKETONURIA%REACTOME%REACT_121117.2 Abnormal metabolism in phenylketonuria 259307 883 3945 5053 101929036 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_11063.2 Degradation of beta-catenin by the destruction complex 5711 5710 5714 5713 1452 5719 3065 8945 2932 7089 23198 139285 7088 6500 5715 5716 1499 5701 7311 5696 5687 5695 5700 166 5694 6932 6934 5717 5718 5688 5689 8454 8312 5720 7316 10213 324 5698 83439 9978 5699 7090 7091 10023 143471 5721 6233 5519 5518 5515 5516 5529 1487 5528 1488 5527 23401 10197 5707 5525 5706 5709 5708 5690 5705 5691 5704 5526 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 51176 5684 5683 MPS VII - SLY SYNDROME%REACTOME%REACT_147759.2 MPS VII - Sly syndrome 23563 10331 2239 3373 79586 9469 3339 126792 9653 3073 3340 3074 6383 11285 10678 9435 3038 9394 10675 3037 3036 2720 283464 8372 100616124 2719 727936 4958 9957 11041 9956 9955 633 3425 1634 3423 11046 79369 27087 9348 347734 11081 411 176 63827 6382 643853 6385 8509 8702 26035 8704 8703 9331 10855 9334 4969 10861 2262 10057 29940 2990 64579 2817 2132 2131 60495 960 55454 10082 6482 6483 6487 6484 1836 6548 135152 56548 266722 10402 51363 22856 221914 222537 93010 10090 10894 55576 2799 6448 8692 337876 26229 90161 64711 166012 11261 375790 3161 113189 5549 9951 9953 9672 1463 4669 2331 51000 8534 50515 4060 1464 9060 1462 55790 2683 92126 55501 4166 9061 79411 54480 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_15309.1 Acetylcholine Neurotransmitter Release Cycle 6616 1103 6572 8541 8499 9256 22999 8497 10497 60482 5864 6844 6804 6857 8500 10815 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_115961.4 PI3K events in ERBB4 signaling 6199 3815 2932 23035 572 2064 2549 1950 5291 5293 1026 27161 3667 2534 5728 117145 145957 79109 2931 5290 1027 4343 8503 1956 2309 5156 8660 5781 7409 2069 26523 5155 7249 3164 2475 1839 3932 23239 842 1147 50852 152831 253260 2264 9965 1385 940 3084 685 57690 942 941 84335 64223 26281 101060747 10818 5296 4193 9542 192669 930 5170 5159 23112 57761 10718 5295 10000 2247 2246 192670 2249 2255 8823 207 27006 208 2251 2252 2254 2308 2248 8817 8074 27327 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%REACT_975.5 RNA Pol II CTD phosphorylation and interaction with CE 728340 1022 2968 2967 5438 5439 5436 8731 902 8732 5437 5434 5435 5431 5433 5430 5432 2962 5440 2963 6829 5441 4331 2068 2071 2965 2966 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME%REACT_1853.3 Post-translational modification: synthesis of GPI-anchored proteins 55650 5329 9487 8818 5281 23556 93183 8733 284098 54872 128869 5279 5283 5277 54965 9488 54344 80055 51604 8813 94005 51227 84720 10026 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME%REACT_75795.1 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 3135 51128 3309 3134 3133 821 22872 6891 9632 811 567 6890 64167 3107 6892 9871 3106 51752 3105 10802 10484 2923 6396 10427 FATTY ACYL-COA BIOSYNTHESIS%REACTOME%REACT_1319.2 Fatty Acyl-CoA Biosynthesis 23305 47 9524 51703 6576 6785 79993 31 2194 3293 51144 54898 2182 2181 253017 83401 2180 64834 60481 79071 METABOLISM OF RNA%REACTOME%REACT_21257.2 Metabolism of RNA 6231 6232 54512 9125 6044 23049 100505503 6043 167227 22894 116936 116938 55746 6228 6229 6227 6235 4736 6230 6234 84546 23404 2197 1656 23016 6606 25904 1994 22794 677847 9887 51690 6224 6223 23293 6222 6607 23019 1432 6203 6201 6202 5518 5515 3842 7175 9883 1981 11340 5600 6210 6205 6204 6208 6209 23225 6206 6207 6217 6218 3921 56915 6137 9939 6136 6138 6139 11218 101060386 6130 6133 6132 6135 6134 6143 6144 6141 6142 7538 6147 606500 6146 55181 9261 552900 4116 11224 1974 1973 23381 1977 1975 56006 6129 6128 4848 23165 4849 23279 5520 79902 4850 6124 6123 51808 6122 25804 6125 574040 219988 619505 7529 6176 6175 7534 129401 196513 26795 3303 10921 55802 6418 51010 9688 4686 51013 29883 9972 26986 3304 7514 5711 5710 5714 55571 5713 5393 5719 23198 26784 26781 5715 26780 5716 6628 5701 7311 5696 5687 5695 26778 5700 5694 6634 5717 5718 6633 5688 26771 5689 6635 6636 6637 8741 5976 26809 25873 54464 100124516 23658 5720 7316 10213 5580 5698 5699 8570 94163 26791 143471 26790 5721 6233 5578 96764 23644 255967 10605 8021 23521 595100 79084 55110 22916 10197 5707 5706 5709 5708 5690 10073 5705 85456 5691 5704 7314 5692 5693 5702 79833 8125 122706 11097 6632 5686 5685 5682 9861 9491 23511 6083 5684 5683 23636 6165 6168 9924 85390 6161 27257 2107 6164 6160 27258 10762 9045 101929876 6167 6169 85388 28960 619567 619568 85389 5903 619565 619499 619562 100302143 8480 100529097 118460 101060589 26819 26815 57472 26817 26818 26816 51121 6193 50628 6194 6192 6191 26019 8487 246175 26820 348995 652965 652966 9631 9349 6171 53371 6170 11157 6173 4927 57819 100526842 10419 26811 8086 3312 26814 6189 6188 9337 3315 6187 1207 595097 595099 207 100996747 100508408 79760 25929 80153 6181 65110 595098 677 23708 5073 57122 6154 6155 6152 9775 6159 8944 6157 6158 79023 65109 6156 SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME%REACT_15439.2 Serotonin and melatonin biosynthesis 15 438 1644 121278 7166 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME%REACT_1079.2 Formation of the ternary complex, and subsequently, the 43S complex 6231 6232 8894 6044 1965 26784 100505503 101929876 85388 1968 1964 6228 6229 6227 6235 6230 6234 84546 2197 3646 6193 6194 6192 6191 8669 94163 6233 8668 101060318 6224 574040 6223 6222 8663 8661 6203 8662 6201 6202 8666 26811 8667 8665 6189 6188 8664 26795 6187 27335 6210 6205 6204 6208 100996747 100508408 6209 6206 6207 6217 6218 3921 8944 DNA DAMAGE REVERSAL%REACTOME%REACT_127.3 DNA Damage Reversal 4255 121642 221120 TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS%REACTOME%REACT_6248.4 Transport of Ribonucleoproteins into the Host Nucleus 9631 53371 10762 4927 55746 8021 8086 5903 9883 7175 129401 8480 3836 9688 23225 3837 9972 23165 11097 57122 23279 79902 23511 79023 348995 23636 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_75886.3 Nonsense-Mediated Decay (NMD) 6231 6232 6044 26784 23049 100505503 26780 7311 116936 26778 116938 6228 6229 6227 6235 4736 6230 26771 6234 84546 5976 26809 25873 2197 100124516 94163 26791 26790 6233 22794 9887 6224 6223 23293 6222 6203 6201 5518 6202 5515 23521 1981 595100 55110 6210 22916 6205 6204 6208 6209 6206 6207 6217 6218 3921 6083 6165 6137 6168 9939 6136 6138 6161 6139 6164 2107 6160 101060386 6130 6133 9045 6132 6135 6167 101929876 6134 6169 85388 6143 6144 6141 6142 6147 606500 6146 619565 55181 619499 619562 552900 4116 100529097 11224 23381 26819 101060589 26815 56006 26817 26818 26816 6129 51121 6128 6193 6194 6192 6191 26019 5520 26820 6124 6123 6122 6125 9349 6171 574040 6170 619505 6173 100526842 6176 6175 26811 26814 6189 6188 26795 6187 595097 595099 10921 100996747 4686 100508408 6181 595098 65110 23708 6154 6155 26986 6152 9775 6159 8944 6157 6158 6156 65109 MITOCHONDRIAL UNCOUPLING PROTEINS%REACTOME%REACT_6341.1 Mitochondrial Uncoupling Proteins 7352 7350 7351 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_147853.2 Mucopolysaccharidoses 23563 10331 2239 3373 79586 9469 3339 126792 9653 3073 3340 3074 6383 11285 10678 9435 3038 9394 10675 3037 3036 2720 283464 8372 100616124 2719 727936 4958 9957 11041 9956 9955 633 3425 1634 3423 11046 79369 27087 9348 347734 11081 411 176 63827 6382 643853 6385 8509 8702 26035 8704 8703 9331 10855 9334 4969 10861 2262 10057 29940 2990 64579 2817 2132 2131 60495 960 55454 10082 6482 6483 6487 6484 1836 6548 135152 56548 266722 10402 51363 22856 221914 222537 93010 10090 10894 55576 2799 6448 8692 337876 26229 90161 64711 166012 11261 375790 3161 113189 5549 9951 9953 9672 1463 4669 2331 51000 8534 50515 4060 1464 9060 1462 55790 2683 92126 55501 4166 9061 79411 54480 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_846.4 Formation of the Early Elongation Complex 728340 1022 2968 2967 5438 100126332 5439 5436 902 5437 5434 5435 5431 5433 5430 5432 22916 2962 7469 5440 2963 6829 100302242 25920 5441 4331 4686 6827 7936 2068 9150 2071 51497 2965 2966 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS%REACTOME%REACT_20633.1 Bile salt and organic anion SLC transporters 345274 9058 9194 9123 23539 26266 6561 55244 6566 64849 146802 284111 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME%REACT_121380.3 Erythrocytes take up oxygen and release carbon dioxide 760 3040 3043 6005 759 358 762 3039 6521 PHASE II CONJUGATION%REACTOME%REACT_6959.4 Phase II conjugation 54988 54576 2729 191 54490 54600 54579 7358 1544 54577 54578 574537 101929773 2730 6799 100616124 10249 445329 347734 116285 27284 79017 27430 10861 6783 7365 7360 10720 23169 1312 7367 54657 7363 4837 7364 54659 7366 341392 10941 54658 1836 100287413 4552 4548 9446 348158 91227 25830 27233 27306 124975 2954 2952 2953 2947 2948 2941 2944 4143 2940 4144 4258 92292 2950 101928916 4259 119391 4257 2679 101929857 55748 7172 10380 123876 2678 2946 9 26873 2949 221357 10 51000 653689 9060 2938 2939 6819 92086 219970 2937 6817 6818 9061 2686 6822 2687 728441 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_22352.1 Highly calcium permeable nicotinic acetylcholine receptors 1135 1134 1143 1136 1141 1137 1142 1138 8973 DOUBLE-STRAND BREAK REPAIR%REACTOME%REACT_2054.4 Double-Strand Break Repair 83990 7520 3981 2547 10111 5893 6119 7518 5591 6118 6117 5888 4361 672 55775 3978 7158 472 9656 4683 3014 675 CHROMATIN ORGANIZATION%REACTOME%REACT_172623.3 Chromatin organization 3066 8335 8334 653604 3065 1019 8337 8331 57634 255626 8358 333932 8352 8359 8353 8354 8338 8339 474382 9575 8357 8356 8347 57459 8348 8345 8346 8340 57504 8343 8344 8341 8342 6604 85236 8968 8360 8362 8361 8364 8363 8295 8365 8366 8970 8368 8349 8367 5928 8351 9112 8350 8355 3013 3012 54815 723790 126961 8294 9612 9611 102157402 10498 5931 8850 554313 121504 9219 3015 3014 8370 3018 3017 53615 6907 1108 1107 2648 128312 595 6871 10524 27097 1387 23028 10933 23522 56970 85235 9767 79960 55929 10943 54934 101929776 55167 100303755 23587 6944 23326 10629 51230 9913 26009 9643 11143 1810 10474 92815 10362 339287 84148 221613 317772 51562 84289 11091 26610 93624 54556 284058 8607 60 55683 55689 23338 8969 86 3054 6314 10445 54859 8464 80314 7994 23774 55250 55257 56943 112869 8518 440689 57325 55578 27154 64769 8329 8089 10902 8520 117143 8332 55140 8330 8473 51147 8336 7862 23186 51317 6881 6880 6883 3717 8841 6597 79084 79718 51742 8819 10856 55170 196528 22992 55193 55818 221656 51412 23081 8284 9682 1386 5978 55693 79685 25855 2033 8289 55869 10419 64426 1788 83933 10284 54496 23135 84678 6603 79595 23133 6601 6602 5253 6605 8242 80853 51780 6595 23030 6599 6598 57492 5926 5927 10765 2874 84159 55352 3276 7403 G2 M DNA DAMAGE CHECKPOINT%REACTOME%REACT_897.2 G2 M DNA damage checkpoint 545 995 983 891 472 7465 1111 84126 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_169168.3 Senescence-Associated Secretory Phenotype (SASP) 1017 8335 8334 653604 8337 1019 8331 255626 7311 1026 1027 8358 51343 333932 8352 8359 8900 8353 8354 8338 8339 246184 2353 474382 8357 8356 8347 7316 8348 8345 890 3576 8346 5598 8340 3552 8343 8344 8341 6233 8342 3021 3020 85236 8968 8360 8362 8361 8364 54145 8363 8365 8366 8970 8368 8349 8367 100616282 8351 8350 8355 5595 3013 3012 6195 723790 7321 6197 126961 8294 7314 6196 554313 121504 3015 5970 3014 8370 5594 3018 4790 3017 996 1030 7324 10919 3569 730268 128312 51433 11065 6774 29882 8697 29945 51529 10393 3725 1021 79813 3490 1051 51434 1029 1031 1032 64682 8881 CAM PATHWAY%REACTOME%REACT_9053.3 CaM pathway 801 156 805 808 1385 5582 107 108 109 5153 112 115 114 111 5577 5137 113 196883 814 5576 5136 5573 5568 5580 5567 5566 5575 5578 INFLUENZA VIRUS INDUCED APOPTOSIS%REACTOME%REACT_6213.4 Influenza Virus Induced Apoptosis 293 7040 AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME%REACT_13721.2 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 1544 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_150154.2 Inositol phosphate metabolism 801 80271 805 808 11165 5333 23262 64768 5330 122618 113026 5332 5331 8867 3633 89869 23007 9807 5728 11163 170685 9651 9677 117283 5335 5336 3613 3612 4952 55190 27124 253430 3631 51447 51196 3705 8821 3707 51477 3706 9562 3635 3636 23236 3632 3628 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME%REACT_1655.5 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 728340 6877 51616 1022 2968 6881 2967 6878 5438 6875 5439 5436 6880 902 6883 6884 6882 5437 5434 5435 2957 5431 2959 2958 5433 5430 5432 6872 6874 2960 2961 2962 2963 5440 5441 6873 138474 4331 2068 102157402 2071 83860 6908 2965 2966 ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_2100.4 Activation of BMF and translocation to mitochondria 140735 5599 90427 LIPID AND LIPOPROTEIN METABOLISM%REACTOME%REACT_602.8 Lipid and lipoprotein metabolism 3931 5034 336 337 116519 857 1071 51099 8029 4023 3949 9619 3339 6382 19 5346 81693 345 4547 348 1208 344 4018 51128 335 2 338 5500 5501 2167 5407 5408 3990 213 5568 5567 5406 5566 3991 26119 11343 319 64241 5499 1056 64240 GLUCOSE METABOLISM%REACTOME%REACT_723.4 Glucose metabolism 2023 8604 5223 7311 5224 4191 2203 5837 5834 4190 10165 5836 5230 6576 378884 5260 2632 8402 7316 5568 5567 8789 5566 5261 230 5091 26330 2806 2805 6233 801 805 5255 808 5256 7167 5257 5214 229 226 2027 2026 178 2597 5519 8908 5236 5518 5515 5516 2821 5528 2997 2998 7957 5507 7314 5106 5105 1468 7360 5213 5210 5208 5207 55276 5211 2992 5209 MRNA EDITING: A TO I CONVERSION%REACTOME%REACT_18.2 mRNA Editing: A to I Conversion 104 103 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME%REACT_25281.4 TRIF-mediated TLR3 TLR4 signaling 330 148022 7322 329 10010 11035 5604 7187 9641 5605 100302736 7311 3656 23118 7336 1845 1848 3654 1849 7099 466 1846 2353 10454 100996792 3665 929 7316 64127 5608 983 7867 3661 6285 353376 4791 29110 5598 7098 177 5599 1660 7334 7335 1147 6283 7189 6233 7297 1385 1432 5519 5518 5515 5516 3717 5595 5600 7323 5528 8517 6195 7321 6197 7314 6196 5970 4792 5594 4793 4790 6885 3551 3569 3570 9261 5781 6288 5606 9252 23643 5601 5602 10392 1386 3146 2002 8767 4615 257397 6416 3725 4205 351 4208 3716 8772 8737 841 5609 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME%REACT_2148.2 Switching of origins to a post-replicative state 5711 1017 5710 5714 5713 5719 23198 5925 5715 5716 5701 7311 5696 5687 1026 5695 5700 5694 5717 5718 5688 5689 1027 51343 8900 5001 4999 5000 4998 4171 5720 7316 10213 4176 5698 890 4174 4175 5699 23595 143471 990 5721 6233 84515 4173 23594 4172 81620 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 5684 5683 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME%REACT_14828.5 Class A 1 (Rhodopsin-like receptors) 729230 3579 3577 11251 101060233 643 9034 6019 9038 2532 100996758 5734 5732 2920 6347 2921 1524 8811 1235 3576 10663 3640 59350 2919 8862 728458 5368 57007 56477 1132 1129 2488 5539 5173 5179 4852 27198 338442 8843 1815 1816 1813 1814 1812 338557 2922 727 56670 718 5660 51052 6364 6363 6361 6366 6367 6752 6753 2841 6360 6751 6750 155 6348 6349 3827 151306 6351 6352 153 154 5739 6356 5473 151 2852 2853 5196 6354 5956 1903 122042 1901 2147 5443 51083 5733 51554 135 2587 3627 4283 5729 283869 134860 414062 134864 256933 10563 9294 1081 9290 9283 59340 3274 11255 3269 553 5020 2652 552 53637 4158 2864 4543 4544 4160 4161 6010 4157 4159 1269 10803 27202 1268 186 187 2826 2834 2833 2832 2831 6372 6370 6374 6373 183 6376 136 611 3062 134 117579 10850 6754 6755 150 152 6387 3973 2492 140 7253 2863 2861 9288 9287 5028 23596 9002 1241 57121 3814 1133 3354 5030 84109 3358 27334 2846 3357 53829 3350 9934 3360 60675 339403 3361 64805 5029 84432 3362 84634 10161 3363 9170 2796 128674 3352 185 2828 3356 3351 2829 3355 10886 10316 83551 624 10800 5995 2798 2797 221391 23620 94233 10887 10692 2867 6863 2865 8477 6915 347148 3061 6288 257313 58191 23566 2693 5724 2862 3060 57105 387129 29933 146 5031 147 5032 148 2925 2840 551 64106 554 594857 6846 4889 1234 4886 4887 8620 7252 680 10022 2150 886 885 6865 6866 6869 6870 2149 5731 5737 1237 1238 1233 351 1236 5697 1232 2358 2359 301 2357 1230 50865 8698 6375 56413 623 10874 129521 2837 1128 5021 7201 51289 719 7200 1131 1910 56923 27199 1908 728 2847 10911 319100 1906 5367 1907 1909 8484 165140 8111 1902 4295 4828 4829 3972 4922 114814 887 4987 84539 7852 4988 2151 4985 4923 4986 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_200716.2 regulation of FZD by ubiquitination 4040 84133 55366 59352 54894 8549 343637 7314 340419 284654 7855 7316 7311 89780 8323 8325 84870 9101 8322 4041 6233 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME%REACT_19140.3 ADP signalling through P2Y purinoceptor 1 5028 2785 2786 51764 2783 2784 2787 59345 2782 2788 94235 2791 9630 1432 55970 2767 5321 2769 54331 2793 10681 2792 2776 2790 ION CHANNEL TRANSPORT%REACTOME%REACT_25300.6 Ion channel transport 482 54822 80036 483 486 80727 2743 1179 1180 2741 1181 57205 54795 94015 2742 57578 63982 10345 121601 4308 101929373 53373 10110 266675 9629 144453 133308 51393 59341 5348 7311 40 441509 7809 170572 22802 374868 1193 51761 162514 79895 540 29850 479 41 477 1184 478 1183 476 285335 9914 1182 23120 1188 285242 1187 1186 481 1185 480 11059 55283 55503 6263 6262 56302 6261 285175 6446 55515 7439 55129 100533105 23229 7442 79054 2570 150159 65266 26133 7316 65267 65268 55107 219931 9635 196527 7223 7224 1831 7226 65125 140803 51802 6233 5894 284525 255231 10786 101927137 7220 203859 338440 9311 8989 23678 6340 6339 57113 6338 6337 54831 50636 259232 57192 57719 28962 57101 100533181 10396 27032 53828 490 5205 491 3359 57198 492 57194 493 5349 496 495 10079 7314 9177 148229 7225 200909 7222 23200 8001 23250 53822 53826 286410 487 51248 489 488 23327 2560 2561 2562 2569 2567 2566 200959 2557 2554 2556 2559 2558 2555 55879 538 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME%REACT_1181.3 Association of licensing factors with the pre-replicative complex 51053 5001 4999 5000 7314 4998 1869 7316 7311 81620 23595 1871 990 1870 6233 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_121189.2 Abacavir transport and metabolism 6581 6582 161823 2987 6580 124 5243 22978 5105 9429 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_115835.1 Termination of O-glycan biosynthesis 4582 4586 118430 27090 283463 10071 6480 256435 94025 140453 10610 727897 56667 4589 4588 200958 6482 6483 6487 57876 6484 4584 4583 394263 143662 4585 NOSIP MEDIATED ENOS TRAFFICKING%REACTOME%REACT_12510.2 NOSIP mediated eNOS trafficking 4846 51070 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME%REACT_691.4 A third proteolytic cleavage releases NICD 5664 4853 55851 4854 4855 83464 51107 23385 4851 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME%REACT_75820.1 Class I MHC mediated antigen processing & presentation 9666 9520 3093 401036 8139 54778 51444 6049 25847 26232 255488 27252 6047 136371 10193 5071 26118 89910 23608 51465 90678 79654 9817 51343 142689 11059 9690 197131 55284 142685 6502 142686 55585 642 7704 151636 127544 9039 997 26273 55070 4012 101929832 122769 9903 92591 126433 10425 80176 64320 26259 4591 115290 54926 22888 3693 10533 51619 83737 10273 23291 8065 8452 2210 9021 2209 996 7324 991 1535 1536 567 730268 653361 51433 7318 4689 4688 11065 29882 100847079 8697 29945 51529 10802 6396 10427 10393 9246 100302652 1520 23352 9320 140739 80196 9730 79876 55182 8924 63891 27338 63893 1514 64219 23304 84727 9354 148581 114088 1515 7317 65264 10075 7319 7325 55176 7320 25898 51676 101929047 51130 79754 101930157 51665 51666 4734 9867 51434 10477 140462 7337 7326 81559 7174 7327 7332 55521 64682 7328 118424 93611 127247 23295 221687 90293 8881 6921 140456 6923 140459 92369 140458 84676 10489 10616 10484 55236 140461 55958 140460 92912 5711 5710 5714 5713 5719 8945 7322 23198 6500 5715 5716 5701 9040 7311 5696 9632 5687 5695 5700 5694 5717 5718 5688 5689 8454 64750 6737 7336 22954 246184 3133 5720 26272 7316 10213 5698 55294 3107 9978 3106 5699 8651 7334 7335 143471 26270 5721 6233 821 868 9902 4360 50489 3105 100132417 101928757 7323 3135 10197 5707 5706 5709 5708 5690 5705 5691 7321 5704 7314 3134 5692 5693 5702 122706 5686 5685 5682 9861 9491 5684 5683 3685 10952 57154 51128 948 9820 2923 23480 23327 3309 22872 6891 811 6890 64167 9871 6892 51752 29927 7428 8453 VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME%REACT_228016.1 VEGFR2 mediated vascular permeability 253260 801 805 857 808 5063 5062 3728 5058 64223 101060747 7410 5879 117145 5170 79109 57761 10000 207 3320 7409 208 10451 1495 4846 2475 1500 1003 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME%REACT_1625.5 p53-Dependent G1 DNA Damage Response 5711 5710 1017 5714 5713 5719 9134 23198 898 5715 5716 5701 7311 5696 5687 1026 5695 5700 5694 5717 5718 5688 5689 1027 5720 7316 64326 10213 5698 5699 143471 5721 6233 7157 4193 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 122706 472 5686 5685 5682 9861 9491 5684 5683 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME%REACT_1132.1 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 8858 5624 2158 2155 2147 2159 5627 2621 5045 2677 79001 ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME%REACT_19180.3 Adrenaline signalling through Alpha-2 adrenergic receptor 150 152 151 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_200788.2 Mitochondrial biogenesis 23410 5465 6742 51106 2101 56652 11232 6907 5565 3054 5564 5563 5571 5469 4899 54205 51422 23054 53632 7978 6300 814 211 7019 5442 64216 6256 801 805 808 6604 1385 8648 96764 1386 1432 4208 8841 133522 80205 5600 1387 506 10891 9611 10498 85441 79718 4209 2551 23082 9572 10499 HIV TRANSCRIPTION INITIATION%REACTOME%REACT_6332.6 HIV Transcription Initiation 728340 6877 51616 1022 2968 6881 2967 6878 5438 6875 5439 5436 6880 902 6883 6884 6882 5437 5434 5435 2957 5431 2959 2958 5433 5430 5432 6872 6874 2960 2961 2962 2963 5440 5441 6873 138474 4331 2068 102157402 2071 83860 6908 2965 2966 REGULATION OF IFNG SIGNALING%REACTOME%REACT_24980.1 Regulation of IFNG signaling 7341 5777 9021 3459 3460 5781 5770 3717 8651 3716 8554 3458 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_200777.2 TCF dependent signaling in response to WNT 8335 8334 54894 653604 3065 8337 8331 255626 123169 2535 8358 1857 333932 1856 8352 8359 8353 8354 8338 8339 474382 1855 8357 8356 8347 80351 8348 8345 8346 8340 11197 6259 9101 8343 8344 8341 8342 3021 4609 4040 3020 85236 56998 8968 8360 8362 9736 8361 4221 8364 283149 54145 8363 8295 8365 8366 5519 8970 8368 5518 8349 83999 8367 5515 8085 100616282 5516 8351 8350 4041 8355 5529 3013 5528 3012 5527 5525 8452 723790 126961 5526 8294 554313 121504 3015 3014 84870 8370 3018 3017 8313 55366 59352 340419 7483 607 128312 8323 8325 8321 8322 59349 7015 26108 22943 440193 8549 27123 10524 27121 6422 7534 6423 1387 9070 8290 89780 1455 7514 5711 5710 5714 857 5713 8607 1452 5719 8945 2932 7089 23198 139285 7088 5715 5716 1499 5701 7311 5696 5687 5695 5700 5694 6932 6934 5717 5718 8395 5688 5689 8312 64750 79577 5720 7316 10213 324 5698 83439 9978 5699 7090 7091 10023 143471 5721 6233 101929777 343637 6597 1487 23401 50964 10197 5929 5707 5706 5709 5708 5690 7471 5705 5691 5704 7314 5692 5693 5702 7473 7474 7478 122706 7479 5686 5685 5682 9861 9491 51176 5684 5683 23072 84133 331 284654 25776 57680 8658 90780 51339 2033 1454 1459 1457 81847 207 208 1460 7855 79412 54361 80319 CENTROSOME MATURATION%REACTOME%REACT_15479.1 Centrosome maturation 11116 27175 984 5048 22919 891 3320 5577 9793 5566 983 1781 1778 203068 9662 22897 10733 7531 80254 11064 10121 10142 7532 55142 4957 7840 5108 1453 22994 5518 80321 9702 121441 4751 1454 7277 1069 10806 8481 22995 55722 8655 5347 55835 55125 80184 27229 85378 10383 79959 54820 10426 10382 10540 11190 114791 8636 9814 728642 9738 22981 55755 7283 84131 23332 5116 95681 11258 7846 10844 4926 PORPHYRIN METABOLISM%REACTOME%REACT_9431.6 Porphyrin metabolism 5498 645 2235 1352 644 1355 3163 3162 211 7390 210 212 1371 7389 3145 54658 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%REACT_1208.1 p53-Independent G1 S DNA damage checkpoint 5711 5710 5714 5713 5719 23198 5715 5716 5701 7311 5696 5687 5695 5700 5694 5717 5718 5688 1111 5689 5720 7316 10213 5698 5699 143471 993 5721 6233 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 122706 472 5686 5685 5682 9861 9491 5684 5683 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_23891.3 Interleukin receptor SHC signaling 3568 3558 3567 1438 3559 3560 1439 5291 5293 3717 5296 3561 3562 3563 3265 1437 3716 5290 6654 8503 3718 5295 9846 5777 3635 3636 6464 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_169415.2 Defective GIF causes intrinsic factor deficiency 55191 4552 1719 4548 32 4594 31 23475 9446 5743 5646 8029 5645 55229 5644 25974 55312 81034 316 53354 55163 8034 6947 10560 55034 81693 9962 3141 9963 56922 60496 60490 27010 8566 166785 23057 5095 326625 5096 101929880 440387 101928493 6948 6470 1504 51293 349565 80025 64087 4338 27249 4524 54 6573 51248 113278 80347 101928717 2694 5091 4522 119391 113235 27304 65220 80704 79178 200895 6515 6513 93100 5167 55788 8884 80308 5740 1528 79717 4363 1582 2194 1727 10135 686 64802 10243 79646 IRS-RELATED EVENTS%REACTOME%REACT_762.1 IRS-related events 1796 29904 6198 7248 51719 81617 101930123 6794 5565 5564 5563 5562 92335 5604 5571 5605 2549 5291 3643 3569 3667 3630 3570 3265 117145 54106 55437 6009 5290 51422 57521 53632 1978 8660 5781 1977 1975 7249 5289 6194 983 2475 30849 5894 152831 2264 7297 9965 5140 7529 3845 64223 4893 26281 101060747 10818 3717 5296 1981 5170 3716 57761 6654 5295 5595 2247 2246 2249 2255 8823 27006 208 2251 2252 2254 2248 8817 8074 5594 5494 TAT-MEDIATED ELONGATION OF THE HIV-1 TRANSCRIPT%REACTOME%REACT_6162.4 Tat-mediated elongation of the HIV-1 transcript 728340 1022 2968 2967 1025 5438 100126332 5439 5436 902 5437 5434 5435 8178 5431 5433 904 5430 5432 22916 2962 6749 2963 7469 5440 6829 100302242 25920 5441 11198 4331 4686 6827 7936 2068 9150 2071 6921 6924 6917 6923 2965 51497 2966 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_75881.2 Methionine salvage pathway 51074 58478 84245 55256 4507 2805 NRCAM INTERACTIONS%REACTOME%REACT_22329.1 NrCAM interactions 6900 1741 1742 8828 286 1739 4897 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_121061.3 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer 4609 23327 1030 1875 1874 3065 1025 1024 4221 60436 54778 7050 7311 51592 6667 6497 100527943 5054 6498 892 4092 142 904 905 64750 7323 3726 7029 7321 7314 9612 9611 4088 25937 4089 7316 8239 5933 7027 5494 4087 6233 AMINO ACID CONJUGATION%REACTOME%REACT_6971.3 Amino Acid conjugation 92292 54988 10249 116285 341392 348158 219970 100287413 123876 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_13552.4 Integrin cell surface interactions 8515 3655 1307 3339 2335 3678 3690 3685 999 7057 3674 1305 3680 2243 7448 3791 645832 91522 2266 2244 5175 80781 3684 3693 100505984 3696 1282 3371 1298 1285 375790 1284 3694 2200 7412 1297 3695 58494 682 3687 1605 3689 8516 1311 3681 3682 3383 3676 50848 3675 3679 22801 1299 83700 1286 3384 3385 3386 3683 3381 6696 4060 3688 961 960 3672 3673 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%REACT_2099.1 Cap-dependent Translation Initiation 6231 6232 6044 26784 26781 100505503 26780 6043 7311 116936 26778 116938 6228 6229 6227 6235 4736 6230 26771 6234 84546 26809 25873 2197 100124516 3646 8669 94163 26791 26790 6233 8668 101060318 677847 6224 6223 6222 6203 6201 6202 23521 1981 595100 6210 6205 6204 6208 6209 6206 6207 6217 6218 3921 6083 6165 6137 6168 6136 6138 6161 6139 6164 6160 8894 1965 8893 6130 6133 9045 6132 6135 101929876 6167 6134 6169 85388 6143 6144 1967 6141 6142 619567 1964 1968 6147 619568 8890 606500 8891 8892 6146 619565 619499 619562 9669 7458 100302143 1978 100529097 1974 11224 1973 1977 26819 1975 26815 1983 26817 26818 26816 6129 51121 6128 6193 6194 6192 6191 26820 652965 6124 6123 652966 6122 6125 9349 6171 574040 6170 619505 6173 8663 100526842 8661 6176 8662 6175 26811 8666 8667 8665 26814 6189 6188 8664 26795 6187 595097 27335 595099 100996747 100508408 6181 595098 6154 6155 26986 6152 6159 8944 6157 6158 6156 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME%REACT_18334.1 NCAM signaling for neurite out-growth 57731 51332 5604 5747 5605 3569 2534 3570 3265 5781 1292 983 1291 784 4684 785 782 64096 783 1293 5894 776 1282 9252 100132336 7297 6900 1385 1298 1285 5786 375790 1284 9048 4902 8128 1297 7903 1287 2674 7529 2675 2668 8911 3845 8912 8913 4893 131873 3717 1299 1463 1286 775 5623 3716 5621 256076 6654 779 5595 6709 6708 6710 6712 5594 6711 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_6844.12 Signaling by TGF-beta Receptor Complex 1030 1875 1874 3065 1025 1024 7048 56288 7046 60436 5045 7040 54778 9040 56937 7311 100527943 11171 142 904 51377 57154 23645 905 64750 7029 2280 4088 7316 4089 9110 9958 5590 7027 57530 5499 6233 4087 25805 23327 4609 50855 387 4221 10273 7050 6667 51592 6497 50848 5054 6498 892 4092 7323 3726 7321 5500 867 5501 7314 9612 9611 25937 8239 5933 4738 101929368 23370 5494 7514 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_933.2 Resolution of AP sites via the single-nucleotide replacement pathway 4913 4968 8930 10309 7515 4350 3980 23583 5423 328 6996 4595 SYNTHESIS AND PROCESSING OF ENV AND VPU%REACTOME%REACT_163660.2 Synthesis and processing of ENV and VPU 5045 SHC-RELATED EVENTS%REACTOME%REACT_999.2 SHC-related events 7297 5781 5604 5605 7529 3845 53358 3643 25759 983 3569 4893 3717 3630 3265 3570 5594 3716 6464 6654 5595 5894 NEF MEDIATED CD8 DOWN-REGULATION%REACTOME%REACT_11200.2 Nef Mediated CD8 Down-regulation 926 160 101927462 100996919 163 1173 51606 161 1175 MUSCLE CONTRACTION%REACTOME%REACT_17044.3 Muscle contraction 10580 800 72 140465 10174 59 4638 7414 25802 4629 7094 3693 801 805 808 88 89 4607 7171 7170 4606 103910 1674 4604 10398 4626 4637 4624 7134 7136 7431 4621 7137 7111 7135 7138 7273 1756 7168 4635 4632 7169 7139 4633 7125 4634 7140 4703 8557 3672 5829 ECM PROTEOGLYCANS%REACTOME%REACT_163906.3 ECM proteoglycans 7040 3912 3690 3685 3915 3674 284217 3680 4148 7448 4593 1758 4038 63923 3911 3910 8785 3913 6678 7148 54829 645832 7143 5802 7043 3908 7042 1834 1404 4146 4684 633 1634 3693 100505984 3371 1298 375790 3694 1297 3687 176 1605 8516 1311 63827 3679 5054 1299 1463 2331 3381 4060 3688 1462 3909 3673 HIV INFECTION%REACTOME%REACT_6185.8 HIV Infection 728340 1022 5438 5439 5436 5062 902 3978 55746 9844 11168 3055 2237 11198 4331 6827 6908 2968 2967 8907 8905 7175 9883 5440 8065 100302242 10053 5441 23225 2068 102157402 2071 2965 2966 160 164 163 162 161 5045 567 5437 5434 5435 2534 1174 1173 51606 1175 375 23165 6917 23279 79902 51616 7520 130340 7518 8178 129401 4869 3981 9688 4686 7936 6921 9972 6924 6923 7514 5711 5710 5714 5713 5719 8945 23198 6500 5715 5716 5701 7311 5696 5687 9397 5695 5700 5694 1794 5879 5717 5718 5688 5689 6872 6874 100500810 6873 138474 4836 5720 7316 10213 100526767 5698 1104 9978 5699 155382 3932 25978 55048 101060363 91782 143471 29082 51160 5721 6233 27183 5478 51534 6877 51652 7251 51510 6881 940 10015 6878 79643 6875 128866 5902 27243 8731 6880 92421 79720 137492 6883 9525 6884 5905 8732 6882 8021 2957 3105 2959 2958 22916 2960 10197 5707 2961 5706 2962 6749 5709 2963 5708 5690 5705 5691 5704 7314 5692 5693 5702 122706 11097 5686 5685 5682 9861 9491 23511 51497 8815 5684 23636 5683 1025 2547 10762 926 920 5903 904 905 8480 292 291 100996919 7469 5901 293 1234 55690 348995 23327 9631 100126332 53371 3159 4927 101927462 8086 5431 5433 5430 5432 3836 6829 25920 3837 9150 83860 57122 7852 79023 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME%REACT_78.3 Post-Elongation Processing of the Transcript 100302196 6428 6429 9939 84967 693221 6430 51692 10250 6628 6432 6431 10189 6634 6635 11051 6636 55110 53981 8106 22916 4116 6637 10921 9295 134353 7884 11338 7307 283459 8683 4686 9785 10914 1477 79869 25888 51362 1478 6427 29894 6426 10978 51585 100126351 65109 1479 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_107.4 Apoptotic cleavage of cellular proteins 22985 28988 51765 6304 10134 660 4137 836 8428 6093 329 5339 5747 4001 118 5588 999 2339 7431 840 63967 2934 1829 6709 100506658 1832 1830 5580 324 841 1828 9414 5317 7082 839 2620 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_13620.1 p75NTR regulates axonogenesis 396 57142 4804 387 9138 4974 100505585 101927057 4099 84894 4803 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_163701.2 FCERI mediated MAPK activation 9402 3497 28916 28442 5063 5062 5604 28454 5605 28912 5058 3569 6850 7410 3265 3570 5879 4067 3937 5781 5335 5336 7409 10451 28908 2353 28299 983 3538 5599 5894 4214 3539 7297 5601 5602 100423062 3542 7529 3725 6416 3845 3514 4893 3717 28776 28876 3716 6654 5595 28874 28896 28834 5594 5609 440786 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME%REACT_953.1 RNA Polymerase I Transcription Initiation 3066 728340 1022 3065 902 30834 1108 1107 2648 10919 5437 5434 5435 221830 9013 9014 677805 9533 4331 57459 7270 6908 57504 79101 10849 54700 64425 692063 2968 2967 100302240 84172 5928 654320 9112 9015 25885 51082 692072 54815 5440 677822 5441 7343 677792 2068 2074 2071 5931 8850 9219 2965 2966 53615 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_21312.1 Activation of Kainate Receptors upon glutamate binding 801 2785 2786 805 808 51764 2783 2897 2898 2784 2787 2788 5330 2791 5331 55970 2901 54331 10681 2793 2899 2792 2790 83988 1741 1742 59345 2782 94235 2900 1739 23236 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME%REACT_717.2 Post-Elongation Processing of Intronless pre-mRNA 100302196 84967 51692 6628 6634 6635 11051 6636 53981 8106 6637 22916 134353 7884 4686 10914 1477 79869 25888 1478 29894 10978 51585 100126351 1479 INSULIN RECEPTOR RECYCLING%REACTOME%REACT_1109.3 Insulin receptor recycling 537 527 528 526 525 3643 523 9114 529 3630 9296 51382 50617 23545 10312 245973 8992 245972 127124 101927180 533 534 535 90423 51606 155066 9550 WNT LIGAND SECRETION IS ABROGATED BY THE PORCN INHIBITOR LGK974%REACTOME%REACT_228014.1 WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 101929777 7480 7481 51699 7482 7483 7484 8724 51384 50999 64840 79971 7471 7476 81029 7473 7474 9559 7477 7478 89780 7479 7472 54361 55737 80326 7475 SODIUM CALCIUM EXCHANGERS%REACTOME%REACT_19320.1 Sodium Calcium exchangers 123041 6547 6543 9187 6546 25769 80024 283652 57419 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_13720.2 Cell death signalling via NRAGE, NRIF and NADE 393 10276 572 4803 7311 83464 51107 7410 89846 5879 23263 7074 7204 23421 8997 1894 26230 11214 29 8874 57449 7409 10451 64857 23229 25791 5664 7316 8878 5599 6233 7189 2245 835 55851 221472 27018 9459 4804 7531 27237 836 23365 6453 9500 5924 4168 6654 9181 7314 121512 10018 9828 26574 101930241 50649 6655 84033 9826 23370 50650 23385 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME%REACT_6782.4 TRAF6 Mediated Induction of proinflammatory cytokines 5604 5605 7311 3569 3570 9261 3656 23118 1845 5781 1848 3654 1849 6288 466 1846 2353 10454 100996792 7316 64127 5608 983 7867 6285 4791 5598 177 5599 1660 1147 6283 6233 7189 5606 9252 7297 1385 5601 5602 10392 1386 3146 2002 8767 4615 1432 257397 5519 3725 6416 5518 4205 351 5515 5516 4208 3717 3716 5595 5600 5528 8517 6195 6197 7314 6196 5970 4792 5594 4793 5609 4790 6885 3551 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME%REACT_15510.1 Recruitment of NuMA to mitotic centrosomes 27229 85378 10426 983 891 121441 114791 27175 7283 10844 4926 HS-GAG BIOSYNTHESIS%REACTOME%REACT_121248.2 HS-GAG biosynthesis 64711 9348 2239 375790 266722 9951 9953 9672 3339 6382 9653 3340 221914 6385 222537 8509 6383 26035 2262 9394 64579 2817 2132 2131 2719 10082 9957 9956 9955 90161 11046 UNCOATING OF THE INFLUENZA VIRION%REACTOME%REACT_6321.4 Uncoating of the Influenza Virion TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_200608.2 Transcriptional activation of mitochondrial biogenesis 23410 5465 801 6742 805 6604 808 51106 1385 56652 2101 8648 96764 11232 6907 1386 3054 5469 4208 4899 8841 54205 23054 133522 80205 1387 506 7978 10891 814 9611 211 10498 7019 85441 79718 4209 5442 2551 23082 64216 6256 9572 10499 CYP2E1 REACTIONS%REACTOME%REACT_13797.2 CYP2E1 reactions 1548 1572 1549 101929829 1571 1559 1565 1555 1553 29785 1557 1558 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_200780.2 Regulation of HSF1-mediated heat shock response 3303 3305 85390 3337 7531 3297 2932 6119 6118 6117 23411 545 57805 3312 85389 472 5594 3304 3306 91582 9261 5595 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME%REACT_18339.3 Adrenaline,noradrenaline inhibits insulin secretion 2785 776 2786 51764 2783 2784 2787 2788 2791 55970 54331 9254 2793 10681 775 2771 2792 2790 2770 150 152 112 59345 2782 94235 111 784 783 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_147798.2 MPS IV - Morquio syndrome B 23563 10331 2239 3373 79586 9469 3339 126792 9653 3073 3340 3074 6383 11285 10678 9435 3038 9394 10675 3037 3036 2720 283464 8372 100616124 2719 727936 4958 9957 11041 9956 9955 633 3425 1634 3423 11046 79369 27087 9348 347734 11081 411 176 63827 6382 643853 6385 8509 8702 26035 8704 8703 9331 10855 9334 4969 10861 2262 10057 29940 2990 64579 2817 2132 2131 60495 960 55454 10082 6482 6483 6487 6484 1836 6548 135152 56548 266722 10402 51363 22856 221914 222537 93010 10090 10894 55576 2799 6448 8692 337876 26229 90161 64711 166012 11261 375790 3161 113189 5549 9951 9953 9672 1463 4669 2331 51000 8534 50515 4060 1464 9060 1462 55790 2683 92126 55501 4166 9061 79411 54480 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_22149.1 Postsynaptic nicotinic acetylcholine receptors 1144 55584 1143 1146 1145 1141 1142 1135 1134 1136 1137 1139 1138 89832 8973 EPHRIN SIGNALING%REACTOME%REACT_228226.1 Ephrin signaling 2051 2047 8874 2049 6386 2048 5063 8440 1947 5062 10627 1949 28964 1948 2050 5058 2534 5879 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_549.3 Activation of BAD and translocation to mitochondria 10000 596 7531 207 208 637 572 7533 7532 7529 5533 5534 2810 10971 7534 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME%REACT_931.2 Ribosomal scanning and start codon recognition 6231 6232 8894 1965 6044 26784 26781 100505503 101929876 6043 85388 619567 1964 1968 619568 6228 6229 6227 6235 6230 7458 6234 100302143 1974 84546 1973 1977 1975 1983 2197 3646 6193 6194 6192 6191 8669 94163 6233 8668 652965 101060318 652966 677847 574040 6224 6223 6222 8663 8661 6203 8662 6201 6202 8666 26811 8667 8665 6189 6188 8664 1981 26795 6187 27335 6210 6205 6204 6208 100996747 100508408 6209 6206 6207 6217 6218 3921 8944 PLATELET DEGRANULATION%REACTOME%REACT_318.7 Platelet degranulation 1072 7423 2277 7414 7040 7424 1950 2335 3690 7057 27154 3082 5660 3674 2621 2243 948 2162 335 2 710 6678 5155 7043 213 3827 2266 7042 2153 2244 5175 5216 5473 101060363 7094 5627 2157 5196 801 5478 805 808 88 226 7450 3309 351 87 3479 5054 7277 10257 440915 7273 7076 7422 6403 5552 5265 928 81 3920 7018 1191 3273 813 7044 10487 10637 3481 29106 6647 22927 967 9948 5340 2316 5341 22915 7114 5345 1675 ABNORMAL CONVERSION OF 2-OXOGLUTARATE TO 2-HYDROXYGLUTARATE%REACTOME%REACT_160183.1 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate 3417 COMMON PATHWAY%REACTOME%REACT_1439.2 Common Pathway 2243 5624 2162 462 7056 2165 2147 2266 2153 2244 2159 5627 5197 5196 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME%REACT_15523.6 Integrin alphaIIb beta3 signaling 10235 10411 54518 7450 9564 5747 2335 6850 3690 1398 101060747 3674 5170 6654 2243 10125 207 5908 5906 11069 2266 1445 5770 2244 7094 6464 TOXICITY OF BOTULINUM TOXIN TYPE C (BONT C)%REACTOME%REACT_200658.2 Toxicity of botulinum toxin type C (BoNT C) 112755 6616 6804 DEFENSINS%REACTOME%REACT_115846.1 Defensins 613210 403339 5646 245908 417 245909 5645 729230 920 117285 644414 414325 728358 55894 140881 140596 400830 140850 100133267 7097 245929 245927 245928 1235 503614 503618 245915 245911 245913 245910 503841 100129216 245939 245940 504180 81623 245930 245934 245932 245937 245936 100289462 245938 1670 1671 1667 1668 1669 613209 1673 1672 613211 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%REACT_408.5 Presynaptic phase of homologous DNA pairing and strand exchange 5893 675 6119 6118 6117 5888 ERKS ARE INACTIVATED%REACTOME%REACT_12436.1 ERKs are inactivated 5519 5528 5518 1845 1848 5515 5516 5598 1849 5594 1846 5595 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME%REACT_18405.2 Acetylcholine regulates insulin secretion 2767 2769 5330 4082 1131 5331 9630 2776 23236 5578 TRUNCATIONS OF AMER1 DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME%REACT_228060.1 truncations of AMER1 destabilize the destruction complex 5711 5710 5714 5713 1452 5719 3065 8945 2932 7089 23198 139285 7088 6500 5715 5716 1499 5701 7311 5696 5687 5695 5700 166 5694 6932 6934 5717 5718 5688 5689 8454 8312 5720 7316 10213 324 5698 83439 9978 5699 7090 7091 10023 143471 5721 6233 5519 5518 5515 5516 5529 1487 5528 1488 5527 23401 10197 5707 5525 5706 5709 5708 5690 5705 5691 5704 5526 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 51176 5684 5683 EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS%REACTOME%REACT_6296.3 Export of Viral Ribonucleoproteins from Nucleus 9631 53371 10762 4927 55746 8021 8086 5903 129401 9883 7175 8480 3303 5901 9688 23225 9972 23165 11097 57122 23279 79902 3304 23511 79023 348995 7514 23636 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_2222.3 Dual incision reaction in TC-NER 728340 1022 2968 2967 5438 5439 5436 56949 902 2067 1161 5437 5434 5435 5431 5433 5430 5432 5440 5441 4331 2068 2074 2071 2073 6917 2072 2965 2966 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%REACT_200626.2 O-glycosylation of TSR domain-containing proteins 170689 10417 157869 10418 171019 7058 9037 55901 7057 92949 9510 9508 9509 170691 54437 170692 81794 100130872 9507 23275 80070 170690 221981 81792 9719 11095 11096 11173 11093 11174 80731 79875 56999 5199 140766 54507 100996396 339366 145173 23145 57188 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_115871.4 Signaling by EGFR in Cancer 6199 3815 2932 5581 23035 5582 572 5604 5605 2064 1950 7311 1026 3265 145957 2931 1027 8503 1956 2309 5156 8660 112 5335 115 8874 114 3320 7409 5137 111 2069 113 26523 196883 5155 814 7316 7249 5580 983 2475 1839 3932 2060 23239 842 1147 50852 6233 5894 5578 253260 801 156 805 7297 808 1385 940 3084 685 9146 942 941 11140 3708 3709 3845 84335 64223 4893 26281 101060747 1211 3717 10818 4193 9542 930 5170 5159 29924 57761 23112 5153 10718 5595 10253 2247 2246 2249 2255 8823 27006 2251 26018 2252 867 2254 7314 2248 8817 8074 1445 5594 5829 160 6868 163 161 2549 8038 5291 5293 27161 58513 3569 3667 2534 5728 3570 117145 79109 8027 5290 4343 5781 1173 102 5577 1175 5136 5576 5573 5568 30011 5567 3164 5566 6456 3710 6464 5575 152831 2264 9965 55824 57690 7529 101927462 107 5296 108 192669 109 3716 6654 5295 10000 192670 207 208 998 2308 27327 10254 10252 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_200610.2 disassembly of the destruction complex and recruitment of AXIN to the membrane 4040 857 1452 2932 139285 1499 5519 5518 5515 5516 2535 8321 4041 8312 1857 5529 5528 1856 5527 23401 5525 7471 5526 1855 7855 324 7478 1455 89780 7479 10023 RAF PHOSPHORYLATES MEK%REACTOME%REACT_614.5 RAF phosphorylates MEK 3845 4893 3265 5604 5605 5894 7529 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME%REACT_1708.3 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 1892 34 3033 3032 3030 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME%REACT_1074.2 RNA Polymerase I Transcription Termination 728340 64425 692063 1022 2968 2967 100302240 84172 902 30834 5437 5434 5435 654320 221830 9015 25885 51082 284119 9013 692072 5440 9014 677822 677805 5441 9533 4331 7343 677792 2068 2071 7270 6908 79101 10849 2965 2966 INTERACTION WITH THE ZONA PELLUCIDA%REACTOME%REACT_163933.2 Interaction With The Zona Pellucida 2683 5016 7783 2515 57829 8747 22917 8748 11085 7784 PROLONGED ERK ACTIVATION EVENTS%REACTOME%REACT_12005.2 Prolonged ERK activation events 7297 5604 5605 7529 4803 3845 1398 4893 3569 10818 3717 3570 3265 3716 5595 5781 5335 673 57498 5906 983 4914 5594 2889 1399 5894 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_6850.1 Cdc20:Phospho-APC C mediated degradation of Cyclin A 5711 996 5710 5714 5713 7324 5719 9184 991 23198 5715 5716 5701 7311 5696 5687 5695 730268 5700 5694 51433 5717 5718 5688 5689 11065 8900 29882 246184 8697 29945 4085 5720 7316 10213 51529 5698 983 890 5699 143471 701 5721 10393 6233 51434 10197 5707 5706 5709 5708 5690 5705 7321 5691 64682 5704 7314 5692 5693 5702 8881 122706 5686 5685 5682 9861 9491 5684 5683 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_121369.2 Acyl chain remodelling of PE 50640 64600 123745 26279 81579 8605 50487 100137049 154141 79887 100652777 11145 255189 129642 30814 5320 283748 5322 8681 5319 5321 10162 254531 8398 8399 SIGNALING BY NOTCH4%REACTOME%REACT_118636.2 Signaling by NOTCH4 5664 3714 55851 4855 83464 51107 182 102 54567 28514 23385 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_118632.3 Trafficking and processing of endosomal TLR 1520 7184 81622 51284 1514 1513 100500842 1515 1508 7098 54106 10695 5641 51311 CA-DEPENDENT EVENTS%REACTOME%REACT_15307.2 Ca-dependent events 801 156 805 808 1385 5582 107 108 109 5153 112 115 114 111 5577 5137 113 196883 814 5576 5136 5573 5568 5580 5567 5566 5321 5594 5575 5578 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME%REACT_6759.2 Formation of ATP by chemiosmotic coupling 498 522 506 539 509 521 9551 4508 10476 4509 10632 27109 513 518 517 516 515 514 101929716 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_12447.2 Negative regulation of the PI3K AKT network 10000 207 208 5728 23035 117145 23239 57761 THE AIM2 INFLAMMASOME%REACTOME%REACT_75777.1 The AIM2 inflammasome 9447 29108 834 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_150471.2 Separation of Sister Chromatids 5711 6232 5710 5714 5713 5719 23198 5715 5716 5701 7311 5696 5687 23047 5695 5700 55746 5885 5694 5717 5718 5688 9126 5689 2491 57082 246184 23244 5720 7316 10213 5698 5699 143471 5721 6233 5905 5519 5518 5515 5516 10726 5347 5529 5528 5527 10197 5707 5525 5706 5709 5708 5690 5705 7321 5691 23122 5704 5526 7314 5692 5693 23332 5702 122706 5686 5685 5682 9861 9491 8243 5684 5683 57405 996 1058 80152 83540 7324 9184 991 699 1062 1063 1060 151648 9183 9232 348235 81565 25909 55166 3796 730268 5903 57551 8379 51433 79019 55920 11130 100527963 5048 22919 23421 11065 55143 55839 91687 64105 81930 79172 29882 6249 9212 8697 80776 29945 4085 84643 3619 9793 51529 25936 401541 11243 100526739 147841 23279 9700 151246 79902 220134 6396 701 10393 348995 378708 23063 113130 51434 55055 54821 54820 11004 9735 79980 79003 64682 5501 10735 79682 64946 54908 10274 10403 332 8881 57122 79023 7514 INOSITOL TRANSPORTERS%REACTOME%REACT_19188.1 Inositol transporters 6523 200010 6527 6526 6524 114134 115584 RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%REACT_977.2 Resolution of D-loop structures through Holliday junction intermediates 3978 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%REACT_75897.1 Tandem pore domain potassium channels 83795 54207 89822 50801 56659 9424 338567 51305 3775 3776 3777 10089 FORMATION OF THE HIV-1 EARLY ELONGATION COMPLEX%REACTOME%REACT_6319.5 Formation of the HIV-1 Early Elongation Complex 728340 1022 2968 2967 5438 100126332 5439 5436 902 5437 5434 5435 5431 5433 5430 5432 22916 2962 7469 5440 2963 6829 100302242 25920 5441 4331 4686 6827 7936 2068 9150 2071 51497 2965 2966 INTERFERON GAMMA SIGNALING%REACTOME%REACT_25078.1 Interferon gamma signaling 115361 3115 6672 100509457 3117 3119 3118 10437 388646 4261 4502 163351 100507709 2633 2635 3113 115362 3122 567 100996809 100507714 101060835 3120 3123 7341 5781 5724 3133 3665 5777 5580 3661 3125 3107 3126 3106 3127 8651 4684 816 817 7412 818 815 3383 3717 3105 3716 100132417 8638 3135 10379 3394 4938 4939 3662 3134 960 4940 2210 9021 3459 2634 3660 3460 5770 2209 3659 3663 3664 5371 8554 3458 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_118572.6 Degradation of the extracellular matrix 1306 6868 1308 7373 1307 4318 5645 5045 136227 5644 3339 3912 999 3915 9510 1303 1305 4317 4316 4312 3818 4319 170692 7177 7077 3817 2 5650 440387 3911 102 11095 1504 11096 10893 4313 4326 101 91522 4325 56999 4327 8754 8751 4324 4323 4320 4322 4321 80781 9313 1991 1634 5663 826 1310 823 84570 1520 1298 4314 836 7093 1297 1514 4811 1513 64386 682 176 63827 1515 1508 1299 6696 7076 9507 3918 170690 1511 3914 960 5340 7092 1215 3909 649 1509 23385 DNA DAMAGE BYPASS%REACTOME%REACT_2174.3 DNA Damage Bypass 5429 51455 10459 5980 CATECHOLAMINE BIOSYNTHESIS%REACTOME%REACT_15551.3 Catecholamine biosynthesis 7054 1644 5409 1621 CASPASE-8 ACTIVATION BY CLEAVAGE%REACTOME%REACT_1503.5 Caspase-8 activation by cleavage 8717 841 8743 355 7186 8772 356 8737 8795 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_169398.2 Loss of Function of SMAD2 3 in Cancer 1030 1875 1874 3065 1025 1024 7048 56288 7046 60436 5045 7040 54778 9040 56937 7311 100527943 11171 142 904 51377 57154 23645 905 64750 7029 2280 4088 7316 4089 9110 9958 5590 7027 57530 5499 6233 4087 25805 23327 4609 50855 387 4221 10273 7050 6667 51592 6497 50848 5054 6498 892 4092 7323 3726 7321 5500 867 5501 7314 9612 9611 25937 8239 5933 4738 101929368 23370 5494 7514 APOBEC3G MEDIATED RESISTANCE TO HIV-1 INFECTION%REACTOME%REACT_9406.2 APOBEC3G mediated resistance to HIV-1 infection 5478 3159 101060363 11168 8815 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_120956.3 Cellular responses to stress 8091 1017 3009 7014 8335 3007 7013 8334 3008 25842 54386 653604 3024 1019 8337 7290 23523 57634 8331 3005 3091 3006 255626 29855 4001 4361 4683 3306 57521 51343 8358 333932 8352 8900 8359 8353 8354 8338 8339 474382 8357 8356 23411 8347 8348 8345 3576 8346 890 8340 8343 8344 8341 8342 3021 3020 85236 8968 8360 816 8362 817 8361 818 8364 54145 1432 815 8363 8365 8366 8970 8368 57805 8349 8367 100616282 5928 8351 8350 91582 23112 8355 5595 2034 5600 3013 3012 7422 405 2056 10728 6195 64344 723790 6197 126961 8294 6196 5931 554313 121504 5970 3015 3014 8370 3018 4790 3017 996 3305 3281 3337 7324 2288 3297 9134 898 5925 10919 3569 730268 128312 51433 1871 1870 9261 4343 11065 6774 29882 8697 29945 51529 2950 10393 6416 6667 3326 25913 1387 51434 3303 30001 26277 10111 64682 545 8881 27327 6921 8290 6923 3456 472 65057 3304 2932 7322 7311 1026 1027 3320 2877 246184 26523 2353 2876 100996792 7316 5608 7867 2475 9978 5598 7027 5599 3552 6233 847 8726 7296 7295 57332 50488 80012 84335 6045 64223 1911 8550 648 1912 23466 4193 84733 6015 9448 4217 8535 23043 7323 7321 768 7314 5594 2077 2113 23512 3397 1030 5034 85390 2114 7415 85389 54205 10013 6119 6118 6117 5606 1915 2146 5601 7531 5602 57690 3159 2033 7157 1869 3725 9588 100129518 3312 10935 2882 1021 79813 192669 3490 1051 1029 2878 55662 25828 10587 7428 54583 7001 192670 112398 493869 1031 8453 1032 112399 23135 5052 475 343 6649 6648 6647 9973 538 5609 BUDDING AND MATURATION OF HIV VIRION%REACTOME%REACT_6359.8 Budding and maturation of HIV virion 5478 23327 51534 51652 7251 51510 10015 79643 128866 27243 92421 79720 137492 9525 7311 7314 7316 100526767 155382 25978 55048 101060363 91782 29082 51160 27183 6233 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_15333.2 Adenylate cyclase inhibitory pathway 112 115 114 111 113 2774 346562 196883 2773 107 108 109 2771 2770 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME%REACT_6828.1 APC C-mediated degradation of cell cycle proteins 5711 996 1017 5710 5714 5713 7324 5719 9184 8945 991 23198 6500 5715 5716 9232 5701 7311 5696 5687 5695 730268 5700 5694 51433 5717 5718 5688 5689 8454 26271 11065 51343 8900 6502 891 29882 9212 246184 8697 29945 4085 5720 7316 10213 51529 5698 983 890 5699 143471 701 5721 10393 6233 5347 51434 10197 5707 5706 5709 5708 5690 5705 7321 5691 64682 5704 7314 8556 5692 5693 5702 8881 122706 6790 5686 5685 5682 9861 9491 5684 5683 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_2192.3 Removal of DNA patch containing abasic residue 5111 2237 6996 57804 4913 4968 5425 8930 10309 4350 5424 3978 23583 10714 5423 328 4595 S37 MUTANTS OF BETA-CATENIN AREN'T PHOSPHORYLATED%REACTOME%REACT_228251.1 S37 mutants of beta-catenin aren't phosphorylated 5711 5710 5714 5713 1452 5719 3065 8945 2932 7089 23198 139285 7088 6500 5715 5716 1499 5701 7311 5696 5687 5695 5700 166 5694 6932 6934 5717 5718 5688 5689 8454 8312 5720 7316 10213 324 5698 83439 9978 5699 7090 7091 10023 143471 5721 6233 5519 5518 5515 5516 5529 1487 5528 1488 5527 23401 10197 5707 5525 5706 5709 5708 5690 5705 5691 5704 5526 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 51176 5684 5683 GAP JUNCTION DEGRADATION%REACTOME%REACT_11035.1 Gap junction degradation 1213 1212 1759 8218 101926921 1785 1211 1601 2697 1173 4646 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_24994.3 Regulation of mRNA stability by proteins that bind AU-rich elements 5711 5710 54512 5714 85390 5713 5393 5719 23198 5715 5716 167227 5701 7311 22894 5696 7538 5687 5695 5700 85389 5694 5717 5718 5688 5689 9261 8741 118460 23404 54464 5720 7316 10213 5580 5698 5699 8570 143471 5721 6233 5578 23016 1994 7529 1432 3842 3312 8021 7534 3315 1981 11340 5600 3303 10197 5707 5706 55802 6418 5709 207 5708 51010 5690 5705 5691 5704 7314 5692 51013 5693 5702 677 8125 122706 5073 26986 5686 5685 56915 5682 3304 9861 9491 5684 7514 5683 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME%REACT_1924.3 ATM mediated phosphorylation of repair proteins 672 472 9656 4683 3014 TRANSPORT OF ORGANIC ANIONS%REACTOME%REACT_23988.1 Transport of organic anions 11309 213 28231 28234 551 6578 10599 353189 53919 6579 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_160106.1 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 3714 6868 182 102 54567 28514 4851 FRUCTOSE CATABOLISM%REACTOME%REACT_1571.3 Fructose catabolism 229 3795 MEIOTIC RECOMBINATION%REACTOME%REACT_27271.2 Meiotic recombination 1017 8335 8334 653604 7156 8337 1019 8331 255626 641 4361 5889 128312 29893 4683 27030 84057 8358 333932 8352 8359 8353 8354 8338 8339 6119 474382 6118 6117 8357 5888 8356 8347 8348 8345 8346 8340 8343 8344 8341 8342 3021 3020 85236 8968 8360 8362 8361 8364 54145 8363 8365 8366 8970 8368 8349 8367 100616282 8351 8350 8355 3013 3012 56154 56979 4438 4439 10111 723790 23626 126961 8294 11144 8290 5932 672 554313 4292 121504 472 3015 3014 8370 3018 675 3017 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_19290.1 G beta:gamma signalling through PI3Kgamma 2785 2786 2783 51764 2784 387 2787 2788 2791 55970 101060747 54331 2793 10681 5170 2792 2790 23533 146850 10000 59345 207 208 2782 94235 5294 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_11167.1 Metabolism of folate and pterines 200895 81034 1719 4524 6573 101928717 6470 4522 113235 CROSSLINKING OF COLLAGEN FIBRILS%REACTOME%REACT_150206.2 Crosslinking of collagen fibrils 7092 649 4015 5118 4016 7093 84171 4017 84695 ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME%REACT_707.4 Activation and oligomerization of BAK protein 578 637 MEMBRANE TRAFFICKING%REACTOME%REACT_11123.5 Membrane Trafficking 4620 5565 5564 5563 5571 4641 2697 2706 1362 2705 51422 53632 4012 1213 1212 9146 8907 8905 1211 10053 4646 164 162 408 7533 8218 101926921 1601 10890 10618 3482 1174 8735 1173 7164 7163 4619 10717 388552 125111 375 6456 10802 6396 10427 152503 8546 51429 22989 8673 27131 57186 2647 6810 81025 9026 130340 10804 26258 51028 57165 25977 7529 4625 4622 375519 286451 81567 5898 8301 9882 54885 7534 2495 84062 10638 51552 4074 55330 23557 2580 79058 149371 5878 10640 2512 5872 127534 23265 23216 1759 7037 9685 5867 1176 11267 57644 4644 219770 6845 9847 11336 6643 54536 57148 55763 84313 2702 2701 1777 2810 10971 6814 23431 6272 8773 55770 2707 10484 9698 60412 8775 2703 6844 2700 2709 9829 7311 9632 1785 5879 22920 100500810 9371 11127 7316 100526767 155382 25978 55048 91782 29082 51160 27183 6233 801 51534 805 51652 808 7251 51510 79643 128866 27243 92421 79720 7532 137492 9525 4626 4624 4621 1522 7314 85390 85389 8027 51128 6517 8766 2799 7082 5286 55738 10052 7531 22872 9871 3312 23433 207 208 4952 9276 1315 10254 8729 10113 22818 11316 22820 1314 4218 372 84694 57369 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%REACT_150417.2 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 1543 2053 1573 1559 1545 1544 1557 1558 MYOGENESIS%REACTOME%REACT_21303.3 Myogenesis 4654 1002 4617 6925 9043 1013 729991 4917 100271849 6938 1496 663 4207 50937 4618 4656 6929 4756 1499 1432 4205 4208 5600 998 25 1495 1000 6300 5608 4209 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_14835.2 Notch-HLH transcription pathway 4853 1387 4854 4855 9794 84441 4851 2648 8850 22938 55534 10046 3516 CELL CYCLE, MITOTIC%REACTOME%REACT_152.6 Cell Cycle, Mitotic 6232 8335 1875 8334 1874 1022 653604 3065 8337 8331 902 255626 23047 3978 55746 1163 51343 8358 5111 333932 8352 51659 8359 8900 5982 6502 8353 5981 8354 5983 2237 8338 5001 8339 4999 5000 474382 7465 4998 4331 8357 23244 8356 9837 4171 8347 5426 5425 8348 4176 8345 5424 890 8346 4174 4175 8340 5985 5984 1763 4149 23595 8343 990 8344 993 8341 994 8342 3021 4609 3020 85236 8968 8360 8362 8361 10142 8364 54145 8363 8365 8366 8970 8368 8349 8367 100616282 5928 8351 10112 9883 23383 10726 8350 25836 9493 8355 5347 3013 3012 5579 23291 723790 126961 23122 8294 23332 554313 121504 3015 3014 8370 3018 3017 57405 996 51053 1058 80152 83540 7324 9184 991 699 9134 23592 898 1062 5925 1063 1060 151648 9183 9232 348235 81565 25909 55166 3796 730268 57551 8379 128312 51433 79019 55920 11130 1871 100527963 1870 5048 22919 23421 11065 55143 55839 91687 23141 64105 81930 79172 29882 6249 9212 7443 8697 80776 29945 4085 84643 3619 9793 51529 23165 25936 401541 11243 100526739 147841 9700 5520 151246 220134 6396 701 10393 378708 5422 157570 595 84515 4173 23594 4172 5427 114799 23649 84296 23063 5557 113130 57804 5558 8318 10714 81620 129401 995 51434 55055 54821 54820 11004 9735 79980 6418 221496 79003 2010 64682 79682 64946 54908 10403 332 8881 5933 7514 1026 1027 7029 3320 983 7027 5578 7298 11097 23511 8815 11116 5903 9631 2033 1454 1459 1457 1460 91754 1017 9133 5861 6241 5862 1019 10783 2801 79648 81876 10592 2029 10776 8615 10051 4001 5885 84962 27175 55957 984 132660 9126 55844 64689 29781 54892 26003 23310 387893 8548 84930 140609 5519 5518 5515 5516 7175 5529 5528 5527 5525 5526 23225 23279 79902 255919 23399 5500 10735 9688 5501 10274 9663 8290 9972 5711 5710 5714 5713 5719 8945 23198 6500 5715 5716 5701 7311 5696 5687 5695 5700 5694 5717 5718 5688 5689 8454 2491 57082 246184 5720 7316 10213 5698 5699 143471 5721 6233 1781 1778 203068 9662 22897 10733 80254 11064 10121 7532 55142 4957 5905 7840 5108 1453 22994 80321 9702 8021 121441 4751 7277 1069 10806 8481 22995 55722 8655 55835 55125 80184 10383 79959 10197 10382 5707 5706 10540 11190 5709 8636 5708 5690 9814 9738 5705 5691 7321 22981 55755 5704 7314 7283 5692 84131 5693 5116 95681 5702 122706 5686 11258 5685 7846 5594 5682 9861 9491 5684 8243 5683 23636 1030 64900 1719 10762 26271 8480 55388 8317 10926 29935 7084 9088 891 28227 5577 6119 6118 6117 23175 5566 348995 7531 53371 4927 1869 8086 91750 1021 1029 27229 85378 10426 7153 1031 114791 1032 64151 728642 2305 23397 8556 5934 10133 4659 896 1859 894 4605 57122 4218 6790 79866 9918 286826 79023 10844 4926 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME%REACT_23947.1 GABA synthesis, release, reuptake and degradation 85390 6616 80331 6539 6538 18 7915 6529 2572 2571 6540 3312 85389 22999 5864 6844 6804 6857 10815 140679 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%REACT_79.2 L13a-mediated translational silencing of Ceruloplasmin expression 6231 6232 6044 26784 26781 100505503 26780 6043 7311 116936 26778 116938 6228 6229 6227 6235 4736 6230 26771 6234 84546 26809 25873 2197 100124516 3646 8669 94163 26791 26790 6233 8668 101060318 677847 6224 6223 6222 6203 6201 6202 23521 1981 595100 6210 6205 6204 6208 6209 6206 6207 6217 6218 3921 6083 6165 6137 6168 6136 6138 6161 6139 6164 6160 8894 1965 6130 6133 9045 6132 6135 6167 101929876 6134 6169 85388 6143 6144 6141 6142 619567 1964 1968 6147 619568 606500 6146 619565 619499 619562 7458 100302143 100529097 1974 11224 1973 1977 26819 1975 26815 26817 26818 26816 6129 51121 6128 6193 6194 6192 6191 26820 652965 6124 6123 652966 6122 6125 9349 6171 574040 6170 619505 6173 8663 100526842 8661 6176 8662 6175 26811 8666 8667 8665 26814 6189 6188 8664 26795 6187 595097 27335 595099 100996747 100508408 6181 595098 6154 6155 26986 6152 6159 8944 6157 6158 6156 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_163932.2 Activation of the phototransduction cascade 2779 9187 5158 2782 6010 1258 5148 1259 2792 5145 OPIOID SIGNALLING%REACTOME%REACT_15295.1 Opioid Signalling 5582 2779 1020 2781 112 115 59345 114 94235 5137 5577 111 113 346562 196883 814 5576 5136 5573 5568 5567 5580 5566 5321 3710 2780 5499 2775 5575 23236 5578 801 2785 156 805 2786 808 51764 2783 1385 2784 2787 5330 2788 2791 5332 5331 3708 3709 5443 84152 5519 5518 5534 55970 5515 107 5516 108 54331 10681 2793 109 2771 5153 2792 2790 2770 5528 5142 5530 5141 5532 5143 2782 5144 2774 729966 5173 2773 5533 5594 4988 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME%REACT_22266.1 Interaction between L1 and Ankyrins 55800 57731 51332 6324 6323 23114 3897 3786 3785 288 286 287 4897 6327 6329 6709 6708 6710 6712 6334 6332 6331 6711 6328 6326 6335 SYNTHESIS OF GDP-MANNOSE%REACTOME%REACT_22423.1 Synthesis of GDP-mannose 5372 5373 386724 4351 29925 29926 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME%REACT_2089.4 RNA Polymerase II Promoter Escape 728340 6877 51616 1022 2968 6881 2967 6878 5438 6875 5439 5436 6880 902 6883 6884 6882 5437 5434 5435 2957 5431 2959 2958 5433 5430 5432 6872 6874 2960 2961 2962 2963 5440 5441 6873 138474 4331 2068 102157402 2071 83860 6908 2965 2966 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_169120.2 Defective TCN2 causes hereditary megaloblastic anemia 55191 4552 1719 4548 32 4594 31 23475 9446 5743 5646 8029 5645 55229 5644 25974 55312 81034 316 53354 55163 8034 6947 10560 55034 81693 9962 3141 9963 56922 60496 60490 27010 8566 166785 23057 5095 326625 5096 101929880 440387 101928493 6948 6470 1504 51293 349565 80025 64087 4338 27249 4524 54 6573 51248 113278 80347 101928717 2694 5091 4522 119391 113235 27304 65220 80704 79178 200895 6515 6513 93100 5167 55788 8884 80308 5740 1528 79717 4363 1582 2194 1727 10135 686 64802 10243 79646 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_8027.3 Processive synthesis on the C-strand of the telomere 5111 5425 5424 3978 10714 2237 1763 6119 6118 57804 6117 INFLUENZA INFECTION%REACTOME%REACT_6167.4 Influenza Infection 6231 6232 5438 5439 6044 5436 26784 100505503 7040 26780 7311 116936 26778 116938 55746 6228 6229 6227 6235 4736 6230 26771 6234 2926 84546 26809 3320 25873 2197 100124516 94163 26791 26790 6233 6224 6223 6222 821 6203 6201 6202 8021 1211 23521 7175 9883 595100 6210 8106 2962 5440 2963 6205 5441 6204 6208 6209 23225 6206 6207 6217 11097 6218 3921 23511 6083 23636 6165 6137 6168 6136 6138 6161 6139 6164 6160 6130 6133 10762 9045 6132 6135 101929876 6167 6134 6169 85388 6143 6144 6141 6142 6147 5437 606500 5434 5903 5435 6146 619565 619499 619562 10898 8480 100529097 11224 26819 26815 5901 293 26817 26818 26816 6129 51121 6128 6193 6194 23165 6192 6191 23279 26820 79902 348995 6124 6123 6122 9631 6125 9349 574040 53371 6171 6170 619505 6173 4927 100526842 6176 6175 811 5610 26811 5611 8086 3843 26814 6189 6188 129401 5431 5433 5430 26795 6187 5432 595097 3303 595099 3836 9688 100996747 100508408 6181 3837 595098 9972 57122 6154 6155 6152 6159 3304 8944 6157 6158 79023 6156 7514 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME%REACT_1206.5 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 9154 2030 9153 55315 3177 222962 64078 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_160123.2 Fcgamma receptor (FCGR) dependent phagocytosis 1072 4651 101930374 3984 4627 60 4620 28442 122618 5581 7454 28454 5747 8976 4641 4690 7525 10006 5058 10093 10092 1398 6850 10458 10552 10097 7410 917 3502 10096 3503 10094 5879 71 9844 10109 4067 3501 5335 3055 3320 7409 5336 26999 51517 84513 28908 695 10810 5580 147179 2268 3708 3709 5595 25 2210 2209 63916 28834 5594 8398 196051 2212 2214 28916 28912 5291 2534 5290 23646 7456 10451 28299 10152 10787 3710 3538 3539 5337 10163 5338 8936 100423062 1793 3542 4650 644150 3514 3326 5296 28776 28876 5295 28874 998 4644 28896 55845 440786 ADENOSINE P1 RECEPTORS%REACTOME%REACT_18288.1 Adenosine P1 receptors 136 140 134 135 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME%REACT_571.3 RNA Polymerase III Transcription Initiation From Type 3 Promoter 55814 6621 27297 5437 84265 5434 5435 101060521 661 7702 6619 51082 55718 5440 171568 5441 5451 9533 10623 10621 51728 10622 11128 10302 55703 55290 6908 6617 6618 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13698.2 Regulation of beta-cell development 3175 6928 3280 390874 256297 3642 5078 50674 3630 4760 3170 3516 10000 4821 6927 3171 2255 3174 4825 207 208 6514 3375 389692 5080 2308 3651 4851 2645 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_22272.1 Signal transduction by L1 3688 1460 5604 5605 8829 5058 3897 3678 3690 3685 7410 5594 5879 1459 4684 1457 3674 1956 3680 5595 PAUSING AND RECOVERY OF TAT-MEDIATED HIV ELONGATION%REACTOME%REACT_6143.6 Pausing and recovery of Tat-mediated HIV elongation 1025 5438 100126332 5439 5436 5437 5434 5435 8178 5431 5433 904 5430 5432 6749 2962 7469 5440 2963 100302242 6829 25920 5441 11198 6827 7936 9150 6921 6924 6923 6917 51497 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_995.7 Apoptotic execution phase 3009 3007 3008 3024 6093 329 5062 5339 5747 3005 3006 4001 5588 999 2339 840 2934 1829 100506658 1832 5580 324 1830 1828 9414 5317 7082 3148 10059 2620 1676 1677 22985 28988 51765 6304 10134 660 4137 836 8428 3146 118 7431 63967 3836 3837 6709 841 839 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_13815.1 Axonal growth inhibition (RHOA activation) 396 57142 4804 387 9138 4974 100505585 101927057 4099 84894 RAP1 SIGNALLING%REACTOME%REACT_23898.1 Rap1 signalling 10235 10125 10411 5908 5906 7529 11069 5568 5909 5567 5566 23108 6494 7534 5894 ERK2 ACTIVATION%REACTOME%REACT_1183.5 ERK2 activation 5594 5605 ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME%REACT_120801.2 Abacavir transmembrane transport 6581 6582 6580 5243 9429 CTLA4 INHIBITORY SIGNALING%REACTOME%REACT_19405.1 CTLA4 inhibitory signaling 10000 5529 5528 5527 5781 5525 207 208 942 941 5526 5519 7525 5518 5515 101060747 5516 1493 2534 3932 5170 4067 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_118614.2 Activated NOTCH1 Transmits Signal to the Nucleus 3714 55851 6868 9148 54492 408 409 7311 8650 83464 113878 182 51107 101930388 1272 28514 102 7314 101928143 4851 92737 8788 1840 5664 142678 7316 23220 54567 23385 57534 83737 6233 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME%REACT_13705.2 Phase 1 - Functionalization of compounds 340665 6916 64816 1545 1544 1548 1551 54498 1583 1581 1543 1580 57834 1549 1576 1573 1579 1559 1565 1577 1555 1553 1557 1558 66002 100861540 126410 130 131 8529 84532 284541 217 216 9971 124 56603 127 6256 51302 125 126 196743 2326 10858 8648 2328 5742 2327 5443 1584 1585 1586 1588 120227 1589 1595 1592 1591 29785 1594 54905 4129 1593 1562 1572 101929829 1571 5740 1582 9420 4051 113612 4128 11283 55902 10499 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME%REACT_22351.1 DCC mediated attractive signaling 1630 998 22885 1793 3983 5747 84448 8976 4690 2534 5879 9423 7204 RELEASE OF EIF4E%REACTOME%REACT_6836.1 Release of eIF4E 1978 64223 2475 1977 6009 57521 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_1321.2 E2F-enabled inhibition of pre-replication complex formation 84515 983 23594 891 5001 4999 5000 23595 4998 993 DAP12 SIGNALING%REACTOME%REACT_147814.2 DAP12 signaling 6199 9402 3815 2932 7305 5581 23035 5582 572 5604 5605 2064 1950 1026 6850 7410 3265 5879 145957 2931 1027 8503 1956 2309 5156 3937 8660 22914 112 5335 115 54209 114 7409 5336 5137 111 2069 113 26523 695 3133 196883 5155 814 3824 3822 7249 5580 983 2475 1839 3932 23239 842 1147 50852 5894 5578 253260 801 156 805 7297 808 100528032 1385 940 3084 685 942 941 3708 3709 3845 84335 64223 4893 26281 101060747 3717 10818 4193 9542 930 5170 5159 5153 23112 57761 10718 5595 2247 2246 2249 2255 8823 27006 2251 2252 2254 2248 8817 8074 5594 2549 5291 5293 27161 567 3569 3667 2534 5728 3570 117145 79109 5290 4343 5781 10451 5577 5136 5576 5573 5568 5567 3164 5566 3710 5575 152831 2264 9965 57690 7529 107 5296 108 192669 109 3716 6654 5295 10000 192670 207 208 2308 27327 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_25195.1 Advanced glycosylation endproduct receptor signaling 830 6288 3146 829 6285 351 177 1650 5589 5594 3958 6283 5595 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_115662.2 Downregulation of ERBB2:ERBB3 signaling 10000 7311 7316 207 3084 208 10193 9542 9101 7314 6233 2064 DUAL INCISION REACTION IN GG-NER%REACTOME%REACT_311.2 Dual incision reaction in GG-NER 728340 1022 2968 2967 7507 7508 6119 902 6118 4331 5887 6117 2067 1643 2068 2071 2073 1642 2072 2965 2966 ALPHA-OXIDATION OF PHYTANATE%REACTOME%REACT_17003.1 Alpha-oxidation of phytanate 26061 5264 10478 11001 PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME%REACT_25396.1 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 57134 10905 4121 SYNTHESIS OF CL%REACTOME%REACT_120920.2 Synthesis of CL 54675 COMPLEMENT CASCADE%REACTOME%REACT_6932.7 Complement cascade 731 101930374 730 4153 28916 28442 10878 733 28454 732 28912 721 1378 629 720 727 729 722 725 713 3502 718 3503 715 712 716 3501 717 7448 714 1604 28908 28299 966 645832 1401 3538 5627 3004 2219 8547 5648 3539 2220 100423062 3542 3514 4179 3426 28776 28876 28874 28896 100293534 3075 28834 1675 735 440786 DNA REPLICATION INITIATION%REACTOME%REACT_2244.4 DNA replication initiation 5422 5426 5427 23649 5557 5558 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_9439.4 FGFR3 ligand binding and activation 2247 2246 2249 8823 26281 2254 8817 8074 REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO%REACTOME%REACT_19376.1 Regulation of Commissural axon pathfinding by Slit and Robo 6091 9353 6092 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_23787.1 Regulation of signaling by CBL 3055 7409 867 29760 7525 5291 5293 1398 6850 2534 5296 2889 1399 4067 5290 8503 5295 TRNA AMINOACYLATION%REACTOME%REACT_15482.3 tRNA Aminoacylation 5464 4677 54938 833 57176 7965 9521 10056 4141 101928623 92935 57505 7453 8565 10352 16 5917 3376 51067 79587 23395 3735 5859 124454 6301 51520 57038 23438 6897 2193 2058 79731 25973 27068 55699 10667 1615 80222 7407 9255 3035 55157 2617 DELETIONS IN THE AMER1 GENE DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME%REACT_228048.1 deletions in the AMER1 gene destabilize the destruction complex 5711 5710 5714 5713 1452 5719 3065 8945 2932 7089 23198 139285 7088 6500 5715 5716 1499 5701 7311 5696 5687 5695 5700 166 5694 6932 6934 5717 5718 5688 5689 8454 8312 5720 7316 10213 324 5698 83439 9978 5699 7090 7091 10023 143471 5721 6233 5519 5518 5515 5516 5529 1487 5528 1488 5527 23401 10197 5707 5525 5706 5709 5708 5690 5705 5691 5704 5526 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 51176 5684 5683 REUPTAKE OF GABA%REACTOME%REACT_23910.1 Reuptake of GABA 6540 6539 6538 6529 PKA ACTIVATION%REACTOME%REACT_15530.2 PKA activation 801 805 808 112 115 114 5577 111 113 196883 5576 5573 5568 5567 5566 107 108 109 5575 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_121408.2 A tetrasaccharide linker sequence is required for GAG synthesis 27087 135152 2239 375790 9672 3339 6382 126792 63827 221914 6385 6383 1463 11285 2262 10675 2817 1464 283464 1462 2719 727936 10082 26229 633 1634 ACTIVATION OF AMPA RECEPTORS%REACTOME%REACT_18338.1 Activation of AMPA receptors 2892 2891 2893 2890 STEROID HORMONES%REACTOME%REACT_15493.1 Steroid hormones 1081 4036 8029 5443 1584 1585 51144 1586 1583 80765 1588 120227 1589 1591 1594 3292 3290 6716 6715 6770 2638 231 3293 147323 79644 3283 3972 3284 5641 134429 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_200686.2 Activation of PPARGC1A (PGC-1alpha) by phosphorylation 5600 10891 5565 5564 5563 6300 51422 5571 53632 1432 VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME%REACT_11070.5 Vitamin B2 (riboflavin) metabolism 55312 54 5167 113278 80308 CDO IN MYOGENESIS%REACTOME%REACT_21402.2 CDO in myogenesis 4654 1002 4617 6925 9043 1013 729991 4917 100271849 6938 1496 663 4207 50937 4618 4656 6929 4756 1499 1432 4205 4208 5600 998 25 1495 1000 6300 5608 4209 CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME%REACT_115589.1 Cysteine formation from homocysteine 875 1491 HIV LIFE CYCLE%REACTOME%REACT_6256.7 HIV Life Cycle 728340 1022 5438 5439 5436 902 7311 9397 3978 55746 11168 6872 6874 2237 6873 11198 4331 138474 4836 6827 7316 100526767 1104 6908 155382 25978 55048 101060363 91782 29082 51160 6233 27183 5478 6877 51534 51652 7251 51510 6881 10015 2968 6878 2967 79643 6875 128866 5902 27243 8731 6880 92421 79720 137492 6883 9525 5905 6884 8732 6882 8021 2957 7175 9883 2959 2958 22916 2960 2961 6749 2962 5440 2963 100302242 5441 7314 23225 2068 102157402 2071 11097 23511 51497 2965 2966 8815 23636 1025 2547 10762 5045 5437 920 5434 5903 5435 904 905 8480 7469 5901 23165 6917 23279 79902 1234 348995 51616 23327 9631 100126332 7520 53371 3159 7518 4927 8086 8178 129401 5431 5433 5430 5432 3981 6829 25920 9688 4686 7936 9150 6921 9972 6924 6923 83860 57122 7852 79023 7514 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME%REACT_9061.5 Toll Like Receptor 5 (TLR5) Cascade 5604 5605 7311 3569 3570 9261 3656 23118 51295 7336 1845 5781 1848 3654 1849 6288 466 1846 2353 7100 10454 100996792 7316 246330 64127 5608 983 7867 6285 4791 5598 177 5599 1660 7334 7335 1147 6283 6233 7189 5606 9252 4214 7297 1385 5601 57161 5602 10392 1386 51135 57162 3146 2002 8767 1432 4615 257397 5519 3725 6416 5518 4205 351 5515 5516 4208 3717 3716 5595 5600 5528 8517 6195 6197 7314 6196 81793 5970 4792 5594 4793 5609 4790 6885 3551 SERINE BIOSYNTHESIS%REACTOME%REACT_115789.1 Serine biosynthesis 5723 26227 29968 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME%REACT_19315.1 Cation-coupled Chloride cotransporters 57468 6559 9990 6560 10723 6557 6558 HYDROLYSIS OF LPC%REACTOME%REACT_120977.2 Hydrolysis of LPC 56261 8605 79887 283748 8681 5321 100137049 255189 123745 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_121155.2 Signaling by FGFR2 mutants 2247 2246 2249 2255 8823 2263 27006 2251 2252 2254 2248 8817 8074 26281 RECYCLING PATHWAY OF L1%REACTOME%REACT_22365.1 Recycling pathway of L1 8986 9252 160 163 7430 161 5962 1808 3897 57698 8650 101927462 1785 1211 101930388 26052 1759 6195 1173 6197 24137 101928143 6196 1175 285643 6456 5594 27330 4478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME%REACT_20506.1 Na+ Cl- dependent neurotransmitter transporters 6530 6533 340024 55117 6539 6538 6534 9152 11254 6529 6582 6570 6571 348932 6540 6536 6531 6580 54716 FUSION AND UNCOATING OF THE INFLUENZA VIRION%REACTOME%REACT_6282.3 Fusion and Uncoating of the Influenza Virion ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME%REACT_2243.4 Assembly of the pre-replicative complex 5711 5710 51053 5714 5713 5719 23198 5715 5716 5701 7311 5696 5687 5695 5700 5694 5717 5718 1871 5688 1870 5689 5001 4999 5000 4998 4171 5720 7316 10213 4176 5698 4174 4175 5699 23595 143471 990 5721 6233 84515 4173 23594 4172 1869 81620 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 5684 5683 ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME%REACT_584.4 Activation, translocation and oligomerization of BAX 581 637 EARLY PHASE OF HIV LIFE CYCLE%REACTOME%REACT_6266.8 Early Phase of HIV Life Cycle 5478 3981 7520 2547 2237 3159 7518 920 3978 101060363 11168 1234 7852 8815 MITOTIC PROMETAPHASE%REACTOME%REACT_682.3 Mitotic Prometaphase 9133 6232 10592 10051 23047 55746 5885 9126 2491 57082 23244 983 5905 5519 5518 5515 5516 10726 5347 5529 5528 5527 5525 23122 5526 23332 8243 57405 1058 80152 83540 9184 991 699 1062 1063 1060 151648 9183 348235 81565 25909 55166 3796 5903 57551 8379 79019 55920 11130 100527963 5048 22919 23421 55143 55839 91687 64105 891 81930 79172 6249 9212 80776 4085 84643 3619 9793 25936 401541 11243 100526739 147841 23279 151246 79902 220134 6396 701 378708 348995 23063 113130 1459 1457 55055 54821 54820 11004 9735 79980 79003 64151 10735 23397 79682 5501 1460 64946 54908 10274 10403 332 57122 9918 79023 7514 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_6841.2 Chylomicron-mediated lipid transport 336 5034 116519 337 51128 335 338 3949 4023 3339 6382 3990 26119 345 4547 348 344 SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME%REACT_150275.2 Synthesis of IPs in the nucleus 253430 51447 9807 64768 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_7963.3 Packaging Of Telomere Ends 7014 8335 7013 8334 54386 8337 8331 255626 128312 8359 8338 8339 474382 8347 8348 8345 8346 8340 8343 8344 8341 8342 85236 8360 8362 8361 8364 54145 8363 8365 8366 8970 8368 8349 8367 3013 25913 3012 26277 723790 8294 8290 554313 121504 3015 3014 65057 8370 3018 3017 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%REACT_15443.3 GRB2:SOS provides linkage to MAPK signaling for Integrins 2243 54518 7450 5747 5908 5906 2335 2266 3690 2244 3674 7094 6654 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_11041.2 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 3295 1646 80270 8648 5740 10005 11001 1582 8309 9420 6718 23600 570 8647 101930400 1645 1581 9971 8644 1109 6256 10998 10499 1593 OXYGEN-DEPENDENT ASPARAGINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_121226.3 Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha 55662 2034 3091 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_75780.1 G protein gated Potassium channels 2785 2786 2783 3760 3761 2784 2787 2788 100996843 3759 55970 54331 2793 2792 2790 3768 3766 100134444 3763 3765 2782 94235 3772 3773 9568 3762 2550 PECAM1 INTERACTIONS%REACTOME%REACT_12519.3 PECAM1 interactions 5777 7525 5781 3690 5335 3685 2534 5175 3932 3635 4067 TIGHT JUNCTION INTERACTIONS%REACTOME%REACT_19373.1 Tight junction interactions 137075 10686 50855 9071 9073 56288 9074 9080 23562 9075 64398 9076 7122 50848 5584 9069 149461 49861 92359 24146 53842 51208 84552 26285 84612 5010 1366 1365 1364 10207 REGULATION OF MITOTIC CELL CYCLE%REACTOME%REACT_21279.2 Regulation of mitotic cell cycle 5711 996 1017 5710 5714 5713 7324 5719 9184 8945 991 23198 6500 5715 5716 9232 5701 7311 5696 5687 5695 730268 5700 5694 51433 5717 5718 5688 5689 8454 26271 11065 51343 8900 6502 891 29882 9212 246184 8697 29945 4085 5720 7316 10213 51529 5698 983 890 5699 143471 701 5721 10393 6233 5347 51434 10197 5707 5706 5709 5708 5690 5705 7321 5691 64682 5704 7314 8556 5692 5693 5702 8881 122706 6790 5686 5685 5682 9861 9491 5684 5683 NFG AND PRONGF BINDS TO P75NTR%REACTOME%REACT_13724.1 NFG and proNGF binds to p75NTR 4804 4803 INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION%REACTOME%REACT_6152.3 Influenza Viral RNA Transcription and Replication 6231 6232 5438 5439 6044 5436 26784 100505503 26780 7311 116936 26778 116938 6228 6229 6227 6235 4736 6230 26771 6234 2926 84546 26809 3320 25873 2197 100124516 94163 26791 26790 6233 6224 6223 6222 6203 6201 6202 23521 595100 6210 2962 5440 2963 6205 5441 6204 6208 6209 6206 6207 6217 6218 3921 6083 6165 6137 6168 6136 6138 6161 6139 6164 6160 6130 6133 9045 6132 6135 6167 101929876 6134 6169 85388 6143 6144 6141 6142 5437 6147 5434 606500 5435 6146 619565 619499 619562 100529097 11224 26819 26815 26817 26818 26816 6129 51121 6128 6193 6194 6192 6191 26820 6124 6123 6122 6125 9349 6171 574040 6170 619505 6173 100526842 6176 6175 26811 5611 3843 26814 6189 6188 5431 5433 5430 26795 6187 5432 595097 595099 100996747 100508408 6181 595098 6154 6155 6152 6159 8944 6157 6158 6156 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_115902.1 SRP-dependent cotranslational protein targeting to membrane 6231 6232 6044 26784 100505503 26780 7311 116936 26778 116938 6228 6229 6227 6235 4736 6230 26771 6234 84546 26809 25873 2197 100124516 23478 23471 9789 90701 1650 94163 26791 26790 6233 6224 6223 6222 28972 6203 6201 6202 23521 58477 6745 595100 6210 6748 6746 6747 6205 6204 6208 6209 6206 6207 6217 6218 3921 6083 6165 6137 6168 6136 6138 6161 6139 6164 6160 6130 6133 9045 6132 6135 101929876 6167 6134 6169 85388 6143 6144 6141 6142 6147 606500 6146 10952 619565 619499 619562 100529097 11224 26819 26815 26817 26818 26816 6129 51121 6128 6193 6194 6192 6191 26820 6124 23480 6726 6123 6122 6729 6728 6125 9349 6727 6171 574040 6170 619505 6173 100526842 6176 6175 26811 55176 26814 6189 6188 6185 29927 26795 6187 595097 595099 60559 100996747 100508408 6181 6184 595098 6154 6731 6155 6152 6730 6159 6734 8944 6157 6158 6156 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME%REACT_567.4 Assembly of the ORC complex at the origin of replication 23594 5001 4999 5000 23595 4998 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME%REACT_1587.3 Homologous recombination repair of replication-independent double-strand breaks 83990 5893 10111 6119 6118 6117 5888 4361 672 3978 7158 472 9656 4683 3014 675 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME%REACT_1541.2 mitochondrial fatty acid beta-oxidation of saturated fatty acids 1892 35 33 34 37 3033 3032 3030 VIRUS ASSEMBLY AND RELEASE%REACTOME%REACT_6270.4 Virus Assembly and Release 811 821 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_25359.1 RIG-I MDA5 mediated induction of IFN-alpha beta pathways 7322 51191 10010 7187 3093 9641 7311 5094 7318 23586 6288 100847079 64135 170506 3665 7316 84166 7128 3661 6285 29110 5300 4791 9474 55593 177 9140 1660 7706 1147 6283 83737 6233 7189 9246 4214 57506 9636 3146 2033 4615 79132 351 54941 3442 3440 3441 1387 7323 80143 3439 8517 3451 3443 3444 7321 7186 8772 3452 7314 3448 3449 8737 3445 3446 8887 3660 841 3659 843 1540 3456 79671 5970 84282 4792 4793 4790 26007 3551 NEUROPHILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME%REACT_12473.2 Neurophilin interactions with VEGF and VEGFR 8829 8828 3791 2321 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME%REACT_150209.2 Synthesis of 5-eicosatetraenoic acids 2879 2877 4056 2876 240 241 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME%REACT_6305.3 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 116228 1537 101929716 4731 4728 4724 9167 4729 84987 9997 29796 51241 6390 6392 9551 6391 6389 7384 1327 7352 7350 1329 374291 7351 7381 7388 1353 51079 7385 7386 1337 1350 498 55967 1351 1340 1349 1345 4696 27109 4695 4694 10128 54205 285521 6341 4535 539 4539 100616403 4537 4536 4698 4697 10632 27089 100532726 4711 4722 522 521 4514 4726 4508 4723 4720 4725 2110 10476 4509 2108 2109 4702 4701 4700 4716 513 54539 4718 4717 518 4712 517 4719 516 4713 515 4714 514 4540 4538 4710 4715 4541 506 509 6834 4709 4707 51204 4708 4706 4704 9377 4705 440567 126328 4519 10975 4513 4512 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_147904.3 Activation of gene expression by SREBF (SREBP) 5465 6604 57678 32 8648 96764 31 4047 6907 4801 7108 6721 4802 4800 3157 9453 6309 5469 6667 1595 1717 23054 80205 79071 1387 4598 6713 2194 2222 10498 2224 85441 3422 4597 79718 6256 10499 10654 AMINE OXIDASE REACTIONS%REACTOME%REACT_1875.4 Amine Oxidase reactions 54498 4128 4129 196743 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_23878.1 N-glycan trimming in the ER and Calnexin Calreticulin cycle 7841 80267 55757 821 11253 56886 55741 9695 23193 811 5589 2923 9761 REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME%REACT_25266.1 Reactions specific to the hybrid N-glycan synthesis pathway 4248 MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME%REACT_20518.3 mRNA decay by 5' to 3' exoribonuclease 25804 27257 51690 55802 23644 11157 219988 27258 54464 80153 23658 57819 167227 1656 196513 SMAC BINDS TO IAPS%REACTOME%REACT_2190.3 SMAC binds to IAPs 840 56616 836 331 842 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME%REACT_22433.2 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 27090 10402 79087 54187 440138 64841 55808 79868 5372 5373 4351 57171 144245 9945 2720 199857 29906 10825 1798 55907 10610 8869 79947 81849 29929 22845 30815 54344 6675 84920 129807 84620 4759 91869 386724 10020 4758 100507589 79644 4597 79796 140838 8813 79053 85365 29925 9526 29926 6489 80896 10195 5238 56052 8128 7903 26503 338596 643853 10559 2673 51046 29880 6480 8818 256435 6482 6483 6487 6484 5476 CELL-CELL COMMUNICATION%REACTOME%REACT_111155.1 Cell-Cell communication 1012 137075 10686 5603 1013 1308 1016 3655 7016 7305 5817 5819 55679 56288 5339 9080 5747 1015 8976 23562 4690 5058 5818 999 5879 2533 9863 10326 6300 5599 10207 1003 1001 1002 1004 50855 1005 9459 88 1007 1008 9071 9073 1006 55742 89 9074 3728 1009 1432 9075 8935 57863 55423 64398 9076 7122 50848 1010 87 5584 23705 9069 977 9423 149461 100288695 23607 84063 49861 92359 84623 29780 8573 3691 5600 7408 3611 24146 6251 3918 1630 57453 3688 3914 1826 64403 53842 54751 1495 1000 2185 961 51208 25945 2318 140885 10979 6709 2316 84552 26285 84612 3909 5010 667 1500 253559 1366 6711 3987 1365 1364 5829 81607 8440 100653194 5291 2534 5290 5781 8826 5777 5296 5295 81 MITOTIC G2-G2 M PHASES%REACTOME%REACT_21391.6 Mitotic G2-G2 M phases 9133 1017 1022 8945 6500 902 7311 84962 27175 55957 984 132660 8454 8900 3320 7465 4331 7316 983 890 993 6233 994 1781 1778 203068 9662 22897 10733 80254 11064 10121 10142 7532 55142 4957 7840 5519 5108 1453 22994 5518 80321 9702 5515 121441 5516 5928 4751 7277 1069 10806 8481 22995 55722 8655 5347 55835 55125 80184 10383 79959 10382 10540 23291 11190 8636 9814 9738 22981 55755 7283 7314 84131 23332 5116 95681 11258 7846 11116 1063 1871 5048 22919 9088 891 5577 9793 5566 5520 7531 2033 1869 91750 1454 995 27229 85378 54820 10426 114791 728642 2305 5500 10133 4659 4605 4218 6790 79866 286826 10844 4926 7514 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_12508.4 Metabolism of nitric oxide 801 5593 805 808 857 1719 207 3320 6697 5805 2643 8976 2644 115677 4846 51070 1785 10434 340481 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME%REACT_19419.1 Amino acid and oligopeptide SLC transporters 160728 153201 6533 57084 340024 8140 117247 6541 9056 26503 9057 92745 246213 6511 57030 6507 54716 6564 6510 6565 140679 206358 6505 6506 55089 10991 121260 23657 6509 6539 6512 55117 84889 6520 11254 1468 6519 6528 124935 56301 54407 348932 81539 51296 6568 8501 11136 23428 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME%REACT_1614.4 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 5711 5710 5714 5713 5719 23198 5715 5716 5701 7311 5696 5687 5695 5700 5694 5717 5718 5688 1111 5689 5720 7316 10213 5698 5699 143471 993 5721 6233 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 122706 472 5686 5685 5682 9861 9491 5684 5683 ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME%REACT_150276.2 Antagonism of Activin by Follistatin 3625 10272 3624 10468 CELLULAR SENESCENCE%REACTOME%REACT_169274.3 Cellular Senescence 8091 1017 3009 8335 7014 3007 8334 7013 3008 25842 653604 54386 3024 8337 1019 7290 23523 8331 57634 3005 3006 255626 29855 7311 1026 4001 4361 4683 1027 51343 8358 333932 8352 8900 8359 8353 8354 8338 8339 246184 2353 474382 26523 8357 100996792 8356 8347 7316 8348 8345 5608 7867 8346 3576 890 8340 5598 7027 5599 8343 3552 8344 8341 6233 8342 3021 3020 8726 85236 8968 8360 8362 8361 7295 8364 54145 1432 8363 57332 8365 50488 8366 80012 8970 6045 8368 8349 1911 8550 8367 100616282 648 5928 1912 8351 4193 23466 84733 6015 8350 9448 4217 23112 8355 8535 23043 5595 5600 3013 3012 6195 723790 6197 7321 126961 7314 8294 6196 5931 554313 121504 5970 3015 3014 5594 8370 3018 2077 4790 2113 23512 3017 3397 1030 996 7324 9134 898 5925 2114 10919 3569 730268 128312 51433 1871 1870 4343 9261 11065 6774 29882 8697 29945 51529 10393 5606 2146 5601 5602 57690 3159 7157 3725 6416 1869 6667 1021 79813 192669 3490 1051 1029 51434 25913 192670 1031 26277 1032 23135 10111 64682 27327 8881 8290 3456 472 65057 5609 RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT.%REACTOME%REACT_20508.1 Rhesus glycoproteins mediate ammonium transport. 51458 6005 57127 SIGNAL ATTENUATION%REACTOME%REACT_508.2 Signal attenuation 1796 8660 2887 53358 3643 25759 1398 3667 3630 5594 6464 6654 5595 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME%REACT_278.6 Platelet Aggregation (Plug Formation) 10235 54518 10411 2812 2811 9564 7450 2147 5747 2335 1398 3690 6850 101060747 4352 7066 3674 5170 6654 2243 150 152 10125 207 5908 5906 2815 11069 2814 2266 5770 1445 2244 151 7094 6464 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME%REACT_11235.3 trans-Golgi Network Vesicle Budding 85390 164 162 408 85389 1785 1362 10618 1174 100500810 3482 7164 7163 2799 10717 388552 375 6456 5286 152503 8546 51429 8673 27131 2647 6810 9026 130340 26258 25977 8907 286451 8905 81567 8301 3312 54885 2495 84062 4074 55330 23557 2580 5878 1522 2512 7037 9685 10053 1176 4952 6845 6643 8729 1777 23431 6272 8773 9698 8775 6844 9829 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_24938.1 TRAF6 mediated IRF7 activation 57506 10010 9641 2033 4615 3442 3440 3441 1387 80143 3439 3451 23586 3443 3444 7186 3452 3448 3449 3445 64135 3446 170506 3665 3660 3661 3659 29110 3456 84282 7706 7189 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_74.3 Gap-filling DNA repair synthesis and ligation in TC-NER 5111 5982 5981 5427 5983 6119 6118 57804 6117 5426 5425 5424 3978 10714 5985 5984 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_13638.2 NRAGE signals death through JNK 2245 393 221472 9459 4804 27237 23365 10276 6453 572 4803 9500 5924 7410 89846 5879 23263 4168 7074 6654 7204 8997 1894 26230 29 11214 8874 57449 9181 7409 10451 64857 23229 25791 121512 9828 10018 26574 101930241 50649 6655 84033 9826 23370 5599 50650 EXTRINSIC PATHWAY%REACTOME%REACT_1573.1 Extrinsic Pathway 2152 7035 2158 2155 2159 U12 DEPENDENT SPLICING%REACTOME%REACT_1753.3 U12 Dependent Splicing 9343 5438 693221 5439 4809 5436 9410 57819 6628 51639 6432 10262 6431 5437 5434 5435 10594 101929240 5431 6634 9416 5433 6633 5430 6635 5432 6636 10992 22916 6637 2962 2963 5440 5441 10907 23020 4686 23450 23451 83443 6632 6427 6426 24148 STIMULATION OF THE CELL DEATH RESPONSE BY PAK-2P34%REACTOME%REACT_13532.2 Stimulation of the cell death response by PAK-2p34 836 5062 INHIBITION OF IFN-BETA%REACTOME%REACT_6320.4 Inhibition of IFN-beta NUCLEOSOME ASSEMBLY%REACTOME%REACT_22344.1 Nucleosome assembly 8335 1058 8334 8607 8337 8331 255626 55166 128312 8467 23421 55839 8359 64105 79172 8338 2491 8339 57082 474382 8347 8348 8345 401541 8346 8340 8343 8344 8341 8342 85236 8360 8362 8361 8364 54145 8363 8365 8366 8970 8368 8349 8367 5928 3013 3012 4869 723790 79682 8294 64946 54069 5931 11339 554313 51773 121504 3015 3014 55355 8370 55320 3018 3017 METHYLATION%REACTOME%REACT_6946.4 Methylation 4552 4548 191 1312 4837 101928916 1544 4143 7172 27430 4144 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME%REACT_7993.3 Telomere C-strand synthesis initiation 5422 5426 5427 23649 5557 5558 REGULATION OF KIT SIGNALING%REACTOME%REACT_111225.1 Regulation of KIT signaling 3815 867 10019 10603 9306 7525 5777 2534 8651 3932 4067 6654 5578 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_150182.2 MASTL Facilitates Mitotic Progression 55844 5519 5518 983 5515 891 5516 2029 10776 84930 TRAIL SIGNALING%REACTOME%REACT_402.3 TRAIL signaling 841 843 8743 8772 8837 8795 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_169238.2 Defects in biotin (Btn) metabolism 55191 4552 1719 4548 32 4594 31 23475 9446 5743 5646 8029 5645 55229 5644 25974 55312 81034 316 53354 55163 8034 6947 10560 55034 81693 9962 3141 9963 56922 60496 60490 27010 8566 166785 23057 5095 326625 5096 101929880 440387 101928493 6948 6470 1504 51293 349565 80025 64087 4338 27249 4524 54 6573 51248 113278 80347 101928717 2694 5091 4522 119391 113235 27304 65220 80704 79178 200895 6515 6513 93100 5167 55788 8884 80308 5740 1528 79717 4363 1582 2194 1727 10135 686 64802 10243 79646 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_160243.1 Constitutive Signaling by NOTCH1 PEST Domain Mutants 3066 3714 6868 3065 3280 54492 1024 6907 23462 6500 7311 2648 83464 10014 51107 8454 9794 26508 10013 84441 102 4851 23493 5664 142678 7316 22938 9978 9759 10046 54567 57534 6233 51564 55851 79885 4609 9148 2033 55869 55534 182 892 8841 3516 28514 388585 83933 1387 9734 7314 9612 9611 8850 79718 23385 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME%REACT_18265.1 Regulation of the Fanconi anemia pathway 545 7311 7316 2177 472 7398 7314 55215 27033 6233 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_116145.2 PPARA activates gene expression 3158 54600 6721 100302263 3157 100996782 2274 29841 1581 1543 1579 4899 219541 23054 4199 11010 7004 7005 7003 284541 9575 10001 2222 84246 29079 123 6256 6604 101928625 96764 7296 81857 183 5244 6095 8800 8841 406 57761 80205 1490 9412 400569 10891 9862 90390 9611 10498 85441 79718 51586 1374 10499 5465 8463 336 2101 6907 1024 27063 5469 55588 5468 1376 27242 376497 51003 9477 26230 948 335 51129 211 23179 9971 23097 116519 8648 23389 4801 9282 10413 4802 112950 4800 54797 2033 19 6667 892 50486 10025 9968 133522 9969 1387 6837 2168 55090 9439 25937 9443 9441 9442 34 8202 3992 2180 6822 9440 9572 4862 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_13464.3 Regulation of activated PAK-2p34 by proteasome mediated degradation 5711 5710 5714 5713 5719 23198 5062 5715 5716 5701 7311 5696 5687 5695 5700 5694 5717 5718 5688 5689 5720 7316 10213 5698 5699 143471 5721 6233 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 5684 5683 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_23905.1 Platelet calcium homeostasis 490 6547 491 492 493 6786 487 3708 7225 3709 7222 6543 6546 3710 57113 84876 5023 489 488 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME%REACT_21393.1 Regulation of Rheb GTPase activity by AMPK 7249 7248 5565 5564 5563 5562 6009 51422 5571 53632 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_75831.1 Activation of G protein gated Potassium channels 2785 2786 2783 3760 3761 2784 2787 2788 100996843 3759 55970 54331 2793 2792 2790 3768 3766 100134444 3763 3765 2782 94235 3772 3773 9568 3762 2550 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_116008.3 PI3K events in ERBB2 signaling 6199 3815 2932 23035 572 2064 2549 1950 5291 5293 1026 27161 3667 2534 5728 117145 145957 79109 2931 5290 1027 4343 8503 1956 2309 5156 8660 5781 7409 2069 26523 5155 7249 3164 2475 1839 3932 23239 842 1147 50852 152831 253260 2264 9965 1385 940 3084 685 57690 942 941 84335 64223 26281 101060747 10818 5296 4193 9542 192669 930 5170 5159 23112 57761 10718 5295 10000 2247 2246 192670 2249 2255 8823 207 27006 208 2251 2252 2254 2308 2248 8817 8074 27327 CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME%REACT_7956.1 Classical antibody-mediated complement activation 101930374 3539 28916 28442 100423062 28454 3542 28912 3514 28776 3502 713 3503 715 28876 712 3501 716 28874 714 28908 28299 28896 1401 28834 3538 440786 ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME%REACT_13639.4 Astrocytic Glutamate-Glutamine Uptake And Metabolism 6506 81539 6507 2752 ION TRANSPORT BY P-TYPE ATPASES%REACTOME%REACT_25149.1 Ion transport by P-type ATPases 482 483 486 57205 101927137 5348 374868 51761 79895 540 479 477 478 476 9914 23120 481 480 100533181 10396 27032 490 53828 491 5205 492 57198 493 487 57194 5349 496 495 10079 148229 23200 538 51248 23250 53822 489 53826 488 286410 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_13606.2 Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels 10369 774 55799 27092 101929306 777 100507353 773 784 9254 785 782 783 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_163725.3 SUMO is proteolytically processed 7341 6613 6612 205564 101929087 29843 59343 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_160086.2 Regulation of actin dynamics for phagocytic cup formation 1072 4651 2212 101930374 3984 2214 4627 60 4620 28442 28916 7454 28454 5747 8976 4641 28912 4690 10006 5058 10093 10458 1398 6850 10092 10552 10097 917 7410 3502 10096 3503 10094 5879 9844 71 10109 3501 7456 3320 7409 10451 26999 51517 28908 695 28299 10810 10152 10787 3538 147179 3539 10163 8936 100423062 1793 3542 4650 644150 3514 3326 28776 28876 5595 28874 998 25 4644 28896 2210 2209 63916 28834 5594 55845 440786 TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME%REACT_9392.5 Transport of connexins along the secretory pathway 2697 2706 2705 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME%REACT_1887.3 Beta oxidation of hexanoyl-CoA to butanoyl-CoA 1892 35 3033 3032 3030 G2 PHASE%REACTOME%REACT_1915.2 G2 Phase 1017 1869 8900 890 1871 CALMODULIN INDUCED EVENTS%REACTOME%REACT_9000.3 Calmodulin induced events 801 156 805 808 1385 5582 107 108 109 5153 112 115 114 111 5577 5137 113 196883 814 5576 5136 5573 5568 5580 5567 5566 5575 5578 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_150312.2 Synthesis of IP3 and IP4 in the cytosol 801 805 80271 808 5333 5330 113026 122618 5332 5331 8867 3633 89869 23007 5728 9651 5335 5336 4952 27124 51196 3705 3707 3706 3635 3636 23236 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_27258.1 Endosomal Sorting Complex Required For Transport (ESCRT) 51534 51652 7251 51510 79643 9146 128866 27243 92421 79720 51028 137492 9525 7311 8027 11267 7314 84313 7316 10254 100526767 155382 25978 55048 91782 29082 51160 6233 27183 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%REACT_20625.2 CREB phosphorylation through the activation of Adenylate Cyclase 5568 1385 5567 5566 107 114 109 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%REACT_25073.1 Molybdenum cofactor biosynthesis 4338 55034 10243 27304 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_12417.8 MicroRNA (miRNA) biogenesis 100302197 192670 27161 54487 57510 23405 5901 192669 6895 8575 29102 26523 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME%REACT_405.3 Transport of the SLBP Dependant Mature mRNA 9631 53371 10762 4927 10189 55746 8021 8086 5903 129401 9883 7175 8480 22916 1977 7884 9688 4686 23225 9972 23165 11097 57122 23279 10482 79902 23511 79023 348995 23636 TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME%REACT_75779.1 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) 9424 3775 10089 PROTEIN FOLDING%REACTOME%REACT_16952.2 Protein folding 60 8877 7411 10471 5202 1155 101929597 6905 6902 6904 6903 402 26272 63971 10517 692201 26985 55294 100996906 54461 26224 22803 6499 26190 8237 26270 26234 84261 6950 347733 7280 83752 81027 10575 10376 10694 22948 10381 100302138 101927137 11328 10576 10564 100507577 7278 26792 84790 10574 6468 84617 10528 908 692213 7277 10383 10382 5204 5201 5203 677812 7203 113457 7846 HH LIGAND BIOGENESIS DISEASE%REACTOME%REACT_228209.1 Hh ligand biogenesis disease 5711 5710 5714 5713 5719 23198 5715 5716 5701 7311 5696 7415 5687 5695 5700 6469 5694 5717 5718 5688 5689 3549 5720 7316 10213 5698 5699 143471 5721 6233 6400 51009 27248 50846 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 122706 84447 5686 5685 55733 5682 9861 9491 5684 10956 5683 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_25283.1 Transferrin endocytosis and recycling 537 527 528 526 525 261729 523 55240 9114 529 9296 51382 50617 23545 57192 10312 245973 8992 245972 127124 101927180 533 7018 534 7037 535 90423 51606 155066 9550 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME%REACT_15364.1 Loss of Nlp from mitotic centrosomes 11116 5048 22919 3320 5577 9793 5566 983 1781 1778 203068 9662 22897 10733 7531 80254 11064 10121 10142 7532 55142 4957 7840 5108 1453 22994 5518 80321 9702 121441 4751 1454 7277 1069 10806 8481 22995 55722 8655 55835 5347 55125 80184 10383 54820 79959 10382 10540 11190 8636 9814 9738 22981 55755 7283 84131 23332 5116 95681 11258 7846 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_163773.2 DEx H-box helicases activate type I IFN and inflammatory cytokines production 6288 3146 170506 4615 3665 6285 351 4791 5970 177 1660 4790 6283 LYSOSOME VESICLE BIOGENESIS%REACTOME%REACT_19287.1 Lysosome Vesicle Biogenesis 85390 8673 164 2647 162 408 130340 8907 8905 81567 3312 85389 1785 4074 1522 1174 100500810 10053 2799 6845 375 1777 6456 6844 9829 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_121249.2 Signaling by FGFR3 mutants 2247 2261 2246 2249 8823 26281 2254 8817 8074 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_25208.1 N-glycan antennae elongation in the medial trans-Golgi 8128 4248 2683 4247 338596 11320 25834 4122 8702 4124 2530 6484 8704 8703 9331 4249 51046 11282 9334 6480 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_121398.2 Signaling by FGFR mutants 2264 8805 7750 11116 1523 2549 3845 4893 26281 10818 3265 6777 6776 5290 6654 6772 5295 399687 2247 2261 2246 613 6774 2249 2255 5335 8823 2263 27006 9208 2251 2252 9846 2254 2248 2260 8817 8074 11052 26127 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE%REACTOME%REACT_2176.6 Recognition and association of DNA glycosylase with site containing an affected purine 4968 4350 4595 INTERACTIONS OF TAT WITH HOST CELLULAR PROTEINS%REACTOME%REACT_6905.3 Interactions of Tat with host cellular proteins 1025 904 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_12435.4 Retrograde neurotrophin signalling 26052 160 1759 10126 163 1173 161 1175 4803 6456 101927462 1785 1211 4914 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147867.3 Translocation of GLUT4 to the plasma membrane 4620 5565 5564 5563 7533 5571 4641 5879 51422 53632 22920 10890 6517 8766 8735 9371 4619 11127 4012 801 805 808 22989 7531 57186 6810 7532 7529 4625 4622 5898 4626 9882 7534 4624 10638 51552 4621 23433 79058 149371 10640 5872 23265 23216 207 208 5867 57644 4644 9847 11336 57148 54536 55763 2810 10971 6814 4218 8773 55770 60412 6844 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_6867.2 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase 11065 51343 51434 996 7324 991 29882 7321 64682 246184 8556 8697 29945 8881 51529 730268 51433 10393 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_25018.2 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation 3656 257397 7311 7316 23118 7314 6885 10454 6233 7189 RSK ACTIVATION%REACTOME%REACT_20510.2 RSK activation 101060747 6195 5594 6197 5170 27330 6196 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_20568.4 CREB phosphorylation through the activation of Ras 801 805 808 1385 88 816 817 2902 818 10142 2904 815 5923 2905 101060747 2906 5924 3265 2903 5170 6237 1742 673 6195 6197 6196 4747 5594 27330 5894 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_121111.2 Downregulation of SMAD2 3:SMAD4 transcriptional activity 64750 23327 7323 3065 7321 7314 9612 60436 54778 9611 4088 7050 4089 7316 7311 51592 6497 8239 100527943 6498 142 5494 4087 6233 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%REACT_8024.5 Initial triggering of complement 2219 101930374 8547 5648 3539 4153 2220 28916 28442 100423062 28454 3542 28912 721 629 3514 720 713 28776 3502 718 3503 715 712 28876 716 3501 717 28874 714 28908 28299 28896 100293534 1401 28834 3538 1675 3004 440786 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_160242.2 Initiation of Nuclear Envelope Reformation 4001 5518 23141 5515 221496 5520 2010 23592 7443 8815 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_19344.3 Costimulation by the CD28 family 3115 9402 100509457 3117 28577 3119 3118 916 915 5063 5062 100507709 3113 3122 7525 5058 920 2534 917 100996809 100507714 5879 117145 101060835 3120 79109 4067 5290 3123 8503 28639 5781 7409 5777 28755 2475 3125 3126 1493 3127 3932 1326 253260 940 151888 942 9020 941 8764 5133 23308 80380 29126 5519 5518 64223 5515 101060747 5516 5296 5170 57761 5295 5529 10000 5528 5527 5525 207 208 998 5526 1445 MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME%REACT_1016.2 Mitotic Metaphase Anaphase Transition 26271 5347 HCN CHANNELS%REACTOME%REACT_75862.1 HCN channels 57657 10021 610 348980 ENDOSOMAL VACUOLAR PATHWAY%REACTOME%REACT_111168.1 Endosomal Vacuolar pathway 1520 1515 3135 567 3107 3106 3105 1514 3134 3133 4012 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_21322.1 Ionotropic activity of Kainate Receptors 801 83988 805 808 2897 2898 1741 1742 2901 2900 1739 2899 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_163931.2 Nuclear Pore Complex (NPC) Disassembly 91754 9133 9631 10783 53371 10762 4927 55746 8021 8086 5903 129401 9883 7175 8480 891 9688 23225 9972 23165 983 11097 57122 23279 79902 23511 79023 348995 140609 23636 MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS%REACTOME%REACT_115893.4 Membrane binding and targetting of GAG proteins 7311 7316 9397 7251 155382 55048 7314 79720 137492 51160 6233 NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME%REACT_13594.2 Neurotransmitter uptake and Metabolism In Glial Cells 6506 81539 6507 2752 PLASMALOGEN BIOSYNTHESIS%REACTOME%REACT_1407.3 Plasmalogen biosynthesis 84188 8443 55711 8540 HDACS DEACETYLATE HISTONES%REACTOME%REACT_228222.1 HDACs deacetylate histones 3066 8335 8334 653604 3065 8337 6907 8969 51742 8331 255626 1108 1107 440689 128312 8329 8332 8819 8358 333932 8330 8352 8359 8353 8336 8354 8338 8339 23186 51317 8357 8356 8347 57459 8348 8345 8346 8340 57504 8343 8344 8341 8342 85236 8968 8360 8362 8361 5978 8364 79685 25855 8363 8365 8366 55869 8970 8368 8349 8367 5928 64426 8351 8841 9112 8350 8355 83933 3013 3012 23028 10284 85235 54815 723790 126961 8294 9612 9611 5931 554313 121504 79718 9219 92815 5926 10362 8370 3018 2874 221613 317772 3017 53615 CHL1 INTERACTIONS%REACTOME%REACT_22292.1 CHL1 interactions 8829 27255 85390 8515 10752 85389 3312 3672 3688 3673 286 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_2202.7 Effects of PIP2 hydrolysis 160851 8527 5583 10235 8526 8525 5581 747 139189 3708 3709 5588 57113 9162 10125 7225 7222 5580 3710 11343 1609 1607 1608 1606 221955 TOLL-LIKE RECEPTORS CASCADES%REACTOME%REACT_6966.11 Toll-Like Receptors Cascades 330 148022 7322 329 10010 5604 11035 7187 9641 5605 100302736 7311 4064 1785 54106 3656 26052 23118 51295 7336 1845 1848 64145 3654 1849 5336 7099 466 11213 1846 2353 695 7097 7100 10454 100996792 170506 3665 929 246330 7316 64127 5608 3661 7867 983 353376 6285 29110 4791 7098 5598 177 8651 5599 1660 114609 7334 7335 1147 6283 51311 6233 7189 7297 1385 1432 5519 5518 5515 5516 3717 5595 5600 5528 7323 8517 6195 6197 7321 7314 6196 5970 5594 4792 4793 4790 6885 3551 8411 3569 3570 9261 948 5781 6288 51284 5289 30849 9450 3684 10695 1520 5606 9252 4214 23643 10333 7184 81622 5601 57161 5602 10392 1386 51135 1514 57162 1513 3146 100500842 2002 3689 8767 4615 257397 1515 6416 3725 1508 59307 4205 351 4208 3716 1759 8772 8737 81793 841 5609 3929 5641 SOS-MEDIATED SIGNALLING%REACTOME%REACT_524.3 SOS-mediated signalling 7297 8660 5781 5604 5605 7529 3845 983 3569 4893 3667 3717 3265 3570 5594 3716 6654 5595 5894 NUCLEOTIDE EXCISION REPAIR%REACTOME%REACT_1826.3 Nucleotide Excision Repair 728340 1022 5438 5439 5436 902 5437 5434 3978 5435 5111 5982 5981 5983 6119 4331 6118 6117 1643 5426 5425 2073 1642 5424 6917 5985 5984 2072 2968 2967 5427 7507 7508 56949 5887 57804 2067 1161 10714 5431 5433 5430 5432 5440 5441 2068 2074 2071 2965 2966 PURINE SALVAGE%REACTOME%REACT_1923.5 Purine salvage 353 161823 51292 271 272 2766 100130460 4860 270 3251 132 1633 100 1716 CYTOSOLIC TRNA AMINOACYLATION%REACTOME%REACT_15306.2 Cytosolic tRNA aminoacylation 4677 5464 833 7965 9521 10056 101928623 4141 8565 7453 16 5917 3376 3735 5859 6301 51520 6897 2193 2058 1615 7407 9255 3035 2617 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME%REACT_25210.1 N-glycan trimming and elongation in the cis-Golgi 57134 10905 79694 4121 4245 SEMAPHORIN INTERACTIONS%REACTOME%REACT_19271.1 Semaphorin interactions 1072 391 3984 3985 4627 9475 7305 2932 6093 5063 5062 55558 2064 8829 1809 10371 10570 9037 91584 5058 1808 2242 1400 1020 5362 56896 5361 2534 5879 8851 4629 4628 54209 3320 5788 7094 5364 388 387 23396 389 23365 5880 2909 9855 103910 79784 27289 10398 3326 4637 6237 3688 998 9723 4233 8482 5365 80031 3672 23129 57556 10507 9826 64218 10154 971 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME%REACT_21272.4 Downstream signaling of activated FGFR 6199 3815 2932 5581 23035 5582 572 5604 5605 2064 1950 1026 3265 145957 2931 1027 8503 1956 2309 5156 8660 112 5335 115 114 7409 5137 111 2069 113 26523 196883 5155 814 7249 5580 983 2475 1839 3932 23239 842 1147 50852 5894 5578 253260 801 156 805 7297 808 1385 940 3084 685 942 941 3708 3709 3845 84335 64223 4893 26281 101060747 3717 10818 4193 9542 930 5170 5159 5153 23112 57761 10718 5595 2247 2246 2249 2255 8823 27006 2251 2252 2254 2248 8817 8074 5594 2549 5291 5293 27161 3569 3667 2534 5728 3570 117145 79109 5290 4343 10817 5781 5577 5576 5136 5573 5568 5567 3164 5566 3710 5575 152831 2264 9965 57690 7529 107 5296 108 192669 109 3716 6654 5295 10000 192670 207 208 2308 27327 AMER1 MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME%REACT_228243.1 AMER1 mutants destabilize the destruction complex 5711 5710 5714 5713 1452 5719 3065 8945 2932 7089 23198 139285 7088 6500 5715 5716 1499 5701 7311 5696 5687 5695 5700 166 5694 6932 6934 5717 5718 5688 5689 8454 8312 5720 7316 10213 324 5698 83439 9978 5699 7090 7091 10023 143471 5721 6233 5519 5518 5515 5516 5529 1487 5528 1488 5527 23401 10197 5707 5525 5706 5709 5708 5690 5705 5691 5704 5526 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 51176 5684 5683 VPR-MEDIATED INDUCTION OF APOPTOSIS BY MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION%REACTOME%REACT_8016.1 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization 292 291 293 PYRIMIDINE METABOLISM%REACTOME%REACT_957.4 Pyrimidine metabolism 4907 1723 64902 7084 151531 7083 100500832 56953 7298 51733 7372 978 7371 7378 1890 84618 1633 1806 1635 83549 30833 1807 790 CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME%REACT_6800.3 Conjugation of phenylacetate with glutamine 116285 348158 MTB IRON ASSIMILATION BY CHELATION%REACTOME%REACT_121118.3 Mtb iron assimilation by chelation 4057 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_12591.4 Glutamate Neurotransmitter Release Cycle 6505 6616 6512 8541 54407 8499 9256 22999 6511 8497 57030 10497 2744 5864 27165 6844 8500 6804 6857 10815 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_163994.2 FCERI mediated NF-kB activation 3539 10235 3497 115727 28916 28442 100423062 28454 3542 28912 257397 3514 101060747 5588 28776 5170 28876 4067 8915 28874 23118 84433 8517 7336 10125 28908 28299 10454 10892 28896 28834 5970 3538 4792 4790 7334 1147 7335 6885 3551 7189 440786 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME%REACT_11048.1 Synthesis of bile acids and bile salts via 27-hydroxycholesterol 1646 80270 8648 5740 1582 9420 6718 101930400 1645 1581 9971 8644 1109 6256 10499 1593 CYCLIN B2 MEDIATED EVENTS%REACTOME%REACT_2101.4 Cyclin B2 mediated events 995 9133 983 993 994 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_9480.2 Gap junction trafficking and regulation 10052 81025 10804 57165 375519 8218 101926921 1211 1785 1601 2697 2706 2705 127534 1759 1173 4646 219770 125111 1213 1212 2702 2701 7082 2707 2703 84694 2700 57369 2709 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_115697.1 Prolactin receptor signaling 1443 1444 5781 2690 8945 2689 2688 6500 9978 5617 3717 6777 6776 5618 8454 1442 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_120863.2 Activated point mutants of FGFR2 2247 2246 2249 2255 8823 2263 27006 2251 2252 2254 2248 8817 8074 26281 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_169256.2 Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD 55191 4552 1719 4548 32 4594 31 23475 9446 5743 5646 8029 5645 55229 5644 25974 55312 81034 316 53354 55163 8034 6947 10560 55034 81693 9962 3141 9963 56922 60496 60490 27010 8566 166785 23057 5095 326625 5096 101929880 440387 101928493 6948 6470 1504 51293 349565 80025 64087 4338 27249 4524 54 6573 51248 113278 80347 101928717 2694 5091 4522 119391 113235 27304 65220 80704 79178 200895 6515 6513 93100 5167 55788 8884 80308 5740 1528 79717 4363 1582 2194 1727 10135 686 64802 10243 79646 HEMOSTASIS%REACTOME%REACT_604.6 Hemostasis 3066 391 10235 653604 3065 1398 7410 3082 8503 8358 333932 8352 64145 8353 8354 7409 29127 7465 8357 8356 5216 3021 3020 88 8968 58494 3687 3676 3675 3479 100616282 10112 8351 83700 8350 3683 9493 8355 5595 7422 928 10125 5579 25 10487 126961 3481 5327 5340 2207 7423 9564 1062 2277 829 7424 3796 830 5547 2243 3818 5624 2162 2161 81930 2 462 7056 2165 2160 710 84643 2815 2814 3827 2266 708 2153 2244 2152 7035 2158 2155 2159 151 3684 5627 5197 2157 5196 2812 2811 1793 7450 2147 3689 7534 3442 10257 3440 3441 1387 3439 11004 3451 3443 3444 3452 3448 3449 3445 3446 3660 3659 3456 3799 1675 3798 482 483 857 5581 5582 9927 23468 139818 1950 2335 6850 1794 27154 3265 5879 481 55669 3797 85440 3937 140628 22920 64147 5335 3833 5336 3832 3835 3831 9371 23186 51317 10938 5155 11127 5890 3665 57572 285643 26153 5580 56992 3661 4602 1795 161882 91768 89953 11343 3932 25970 2625 4778 2623 2624 4097 5578 5894 2627 226 682 3845 4893 101060747 3717 5170 54210 5770 160851 5028 5583 9002 139189 64805 9056 9057 2768 146850 5329 6915 10451 6520 5906 1609 1607 1608 11136 1606 23428 221955 8527 51744 388 7010 387 8526 5271 8525 5270 57126 5269 8140 90952 747 5055 5880 2149 6401 6404 2033 6693 6402 6654 51378 9162 23759 914 998 120425 10461 285 284 9046 1525 6281 2734 4973 965 962 101929889 5328 302 2151 8832 2888 1017 3655 3043 7040 5889 2621 10672 5908 2776 2982 5593 51764 2983 6547 4842 4843 6786 2791 2977 2268 8654 3708 3709 5140 1432 5138 5519 5139 5518 6543 2767 50848 2769 5515 87 5516 57113 84876 4352 2778 7066 10681 27345 27094 5153 5152 10846 5529 5528 5527 490 491 5525 492 3688 23657 493 5294 5526 7225 960 7222 2316 56301 1445 4099 10411 408 409 5291 2534 7057 5660 5290 5781 10242 59345 487 5136 5777 213 10335 4846 6546 5321 3710 5590 5175 5739 5023 489 5473 488 3779 6464 3778 7804 50940 2785 2786 2783 2784 2787 54518 2788 6810 55970 54331 51206 2793 2771 2792 2790 2770 7975 23028 23414 64837 55619 3045 3046 2782 81704 3048 3047 147700 24137 8165 80005 55604 2773 832 11311 23764 11069 81928 50808 6814 5868 10362 30845 30846 11216 221037 23348 9732 1072 27040 9630 5747 7525 1020 5588 4067 4312 94235 346562 2626 101060363 5478 801 805 808 9123 23539 6566 55423 7277 23533 7273 150 152 961 140885 3672 3673 5594 8515 10019 10603 7414 3897 3678 3690 3685 3674 948 335 338 5577 6678 5576 5573 7043 5568 5567 7042 5566 3705 7094 5575 3309 7157 351 5054 5296 440915 5295 7076 10000 6403 5552 5265 81 3920 7018 207 208 1191 3273 813 7044 10637 29106 6647 22927 967 9948 5341 22915 7114 2886 5345 25942 3635 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_160254.1 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 3066 3714 6868 3065 3280 54492 1024 6907 23462 6500 7311 2648 83464 10014 51107 8454 9794 26508 10013 84441 102 4851 23493 5664 142678 7316 22938 9978 9759 10046 54567 57534 6233 51564 55851 79885 4609 9148 2033 55869 55534 182 892 8841 3516 28514 388585 83933 1387 9734 7314 9612 9611 8850 79718 23385 ARMS-MEDIATED ACTIVATION%REACTOME%REACT_12002.4 ARMS-mediated activation 7297 5781 57498 673 5604 5605 4803 5906 7529 3845 983 3569 4893 1398 3717 4914 3265 3570 5594 3716 5595 5894 SIALIC ACID METABOLISM%REACTOME%REACT_200874.2 Sialic acid metabolism 27090 8128 7903 10402 26503 338596 643853 10559 51046 6480 54187 55808 256435 2720 29906 55907 10825 8869 10610 81849 30815 129807 84620 4759 4758 10020 6482 140838 6483 6487 6484 6489 5476 80896 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME%REACT_23824.3 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 2864 139760 1803 60559 3670 5080 28972 2626 5122 23478 2695 9789 90701 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_12442.3 AKT phosphorylates targets in the nucleus 2309 6199 10000 1385 3164 207 208 2308 MRNA EDITING: C TO U CONVERSION%REACTOME%REACT_167.2 mRNA Editing: C to U Conversion 29974 339 FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_9400.3 FGFR1b ligand binding and activation 2247 2246 2255 27006 2248 PROLINE CATABOLISM%REACTOME%REACT_1002.4 Proline catabolism 5625 8659 G ALPHA (Z) SIGNALLING EVENTS%REACTOME%REACT_19333.3 G alpha (z) signalling events 2785 5583 2786 51764 2783 2784 2787 2788 5581 2791 5582 5999 55970 5588 107 10287 108 2778 54331 10681 2793 109 2771 2792 2781 2790 2770 150 8601 152 112 5579 115 59345 114 2782 94235 111 113 346562 196883 2773 26575 5580 151 5578 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_21281.5 TAK1 activates NFkB by phosphorylation and activation of IKKs complex 10392 3146 8767 4615 257397 351 3656 23118 8517 3654 6288 10454 64127 6285 4791 177 5970 4792 1660 4793 4790 1147 6283 6885 7189 3551 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_147860.2 MPS IIIC - Sanfilippo syndrome C 23563 10331 2239 3373 79586 9469 3339 126792 9653 3073 3340 3074 6383 11285 10678 9435 3038 9394 10675 3037 3036 2720 283464 8372 100616124 2719 727936 4958 9957 11041 9956 9955 633 3425 1634 3423 11046 79369 27087 9348 347734 11081 411 176 63827 6382 643853 6385 8509 8702 26035 8704 8703 9331 10855 9334 4969 10861 2262 10057 29940 2990 64579 2817 2132 2131 60495 960 55454 10082 6482 6483 6487 6484 1836 6548 135152 56548 266722 10402 51363 22856 221914 222537 93010 10090 10894 55576 2799 6448 8692 337876 26229 90161 64711 166012 11261 375790 3161 113189 5549 9951 9953 9672 1463 4669 2331 51000 8534 50515 4060 1464 9060 1462 55790 2683 92126 55501 4166 9061 79411 54480 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME%REACT_19275.1 Sodium-coupled phosphate cotransporters 6574 6569 142680 6575 10568 MRNA 3'-END PROCESSING%REACTOME%REACT_1849.3 mRNA 3'-end processing 100302196 6428 6429 9939 693221 51692 6430 10250 6432 6431 10189 11051 55110 53981 8106 22916 10921 4116 9295 11338 7307 283459 8683 4686 9785 10914 1477 79869 51362 1478 6427 29894 6426 10978 51585 100126351 65109 1479 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_21384.2 Thrombin signalling through proteinase activated receptors (PARs) 2785 2786 51764 2783 9002 2784 2787 2788 2791 408 409 2147 2149 9630 2768 2767 55970 2769 54331 2793 10681 2792 2790 5595 10672 59345 2782 94235 5594 2776 2151 METABOLISM OF PROTEINS%REACTOME%REACT_17015.6 Metabolism of proteins 6231 6232 6044 6043 6228 6229 6227 6235 6230 6234 23404 2197 3646 9789 1650 5589 6224 6223 6222 338596 6203 11320 25834 6201 6202 3479 4249 51046 11282 29880 6480 6210 6205 6204 3481 6208 6209 6206 6207 6217 5340 6218 3921 56915 139760 1045 338557 1803 2922 3952 80267 55757 56886 55741 9114 5624 11224 22901 2158 2155 2159 5627 6396 101929857 619505 2147 5443 1431 55176 516 26795 55676 149371 27335 10640 148867 30001 23265 169026 1363 51010 340075 4644 56605 51013 5122 11336 54536 55763 5126 3800 5873 26986 3799 55770 60412 1369 6844 3798 5476 6804 64924 1081 8604 5393 26784 26781 26780 1537 26778 6901 10165 2931 26771 7411 10471 5202 10678 25873 4759 4758 8570 94163 26791 26790 79369 6950 101060318 347733 7280 81027 10575 10376 10694 22948 10381 101927137 10576 411 2641 7278 84790 28972 10574 821 84617 908 643853 23521 58477 6745 595100 54543 100287932 25813 26517 51025 100130872 6748 7416 94025 150274 170690 6746 4580 2688 140453 6747 26520 100188893 197257 354 26515 5069 26519 11253 26521 9695 677812 7203 113457 6165 100652748 6168 56993 131474 131118 6161 29090 6164 3329 3313 6160 9804 401505 3487 3488 3489 29928 9045 10063 10402 10651 6167 617 6169 653252 3816 10245 10440 619569 10452 619567 26085 619568 2671 10469 60676 80273 619565 9512 23203 92609 619562 134266 1678 7458 9868 440138 7341 291 10054 5329 6613 79868 7841 6612 100529097 51128 205564 118460 8733 7991 10055 101929087 128869 144245 199857 1798 293 29843 1603 3703 29929 84061 23193 51121 84920 6193 80055 51604 6194 91869 3483 100507589 6192 3485 79796 94005 6191 3486 79053 85365 9526 2923 10026 9761 10195 7252 56052 6171 6170 6173 4248 3998 26503 22872 100526842 5611 9871 6189 6188 6185 6187 5204 100996747 5201 6181 5203 6184 4247 57134 10113 10905 90411 23708 79694 4122 6154 4121 6155 4124 6152 3972 2530 4245 6159 6157 285362 6158 6156 54512 10331 100505503 167227 1984 83475 22894 1725 8858 116936 116938 56648 4736 2621 2677 79001 1917 84546 2720 9451 6347 23478 23471 79642 3484 3421 3576 467 79644 9709 90701 8669 8668 23016 51764 677847 8720 64061 51726 56005 9797 10559 1663 2673 118 11015 7709 8702 8704 4000 27230 1981 8703 9331 10954 11340 116138 10897 10130 9334 3626 3625 3624 3623 94027 93659 2488 1082 94115 5526 6482 6483 6487 6484 114335 83729 4582 498 79623 6137 4586 51301 6136 170689 6138 118430 6139 2395 192134 8877 27090 27235 283463 10417 157869 10418 6130 2589 6133 5045 171019 6132 2590 6135 2591 6134 644378 6143 7058 6144 9037 6141 10071 6142 11226 6147 168391 606500 55901 7057 6146 92949 442117 9510 11227 26290 9508 9669 9509 140687 9245 1155 100528030 1978 101929597 170691 170692 6905 84002 1974 1973 23275 1977 50614 374907 1975 63917 2650 10825 11095 1983 10610 11096 6902 11093 6904 50 56913 6903 402 374378 4589 6129 6128 80731 56999 4588 8681 140766 79695 4597 200958 64409 117248 57876 10802 145173 114805 4584 10427 6464 4583 4585 51809 6124 6726 6123 6122 6729 2784 6728 6125 6727 574040 8128 7903 6176 6175 100500804 29071 8693 54437 158078 81794 9507 256435 80070 221981 81792 55568 9719 727897 57452 7329 11173 84752 11174 56667 2683 146712 79875 5199 54507 101928934 100996396 37 6731 84447 339366 6730 10484 6734 43 23145 394263 143662 57188 60 7311 9632 100137049 6934 2864 4312 3817 26809 3670 346562 4313 100124516 2626 2695 26272 63971 10517 692201 26985 55294 100996906 54461 440 26224 445329 22803 6499 26190 8237 26270 26234 84261 6233 183 416 415 410 414 412 7277 51360 51227 84720 55650 2999 4311 9487 10383 8818 1522 5281 10159 10382 9314 23556 619373 93183 7941 284098 54872 1511 5279 5283 5277 54965 9488 1359 59272 7846 2028 1509 5972 1636 290 6083 1360 1361 590 2107 8894 1965 8893 25870 101929876 347527 85388 1967 1964 1968 8890 8891 8892 10952 93010 3630 79087 619499 59343 100302143 153642 54187 64841 55808 2137 5372 5373 4351 57171 26819 26815 9945 29906 55907 8869 26817 79947 81849 26818 22845 30815 26816 10106 54344 6675 10525 129807 9820 84620 55033 386724 4189 10020 30827 55062 140838 8813 9570 7466 101928061 29925 2081 55738 26820 7094 29926 3068 6489 80896 1639 1200 5238 652965 23480 1915 83752 652966 7184 9349 100302138 4801 11328 22926 10564 1649 100507577 3309 26792 4802 100500842 6468 8663 10528 4800 468 692213 8661 8662 811 8666 26811 8667 8665 26814 8664 29927 595097 1936 595099 506 60559 1933 1937 5080 1938 100508408 595098 6818 1215 5073 8944 REGULATION OF SIGNALING BY NODAL%REACTOME%REACT_111059.2 Regulation of signaling by NODAL 6997 55997 130399 4838 91 7044 10637 93 92 9350 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME%REACT_894.2 RNA Polymerase II Transcription Termination 100302196 6428 6429 9939 84967 693221 6430 51692 10250 6628 6432 6431 10189 6634 6635 11051 6636 55110 53981 8106 22916 4116 6637 10921 9295 134353 7884 11338 7307 283459 8683 4686 9785 10914 1477 79869 25888 51362 1478 6427 29894 6426 10978 51585 100126351 65109 1479 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME%REACT_19241.3 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) 3158 54600 6721 100302263 3157 100996782 2274 29841 1581 1543 1579 4899 219541 23054 4199 11010 7004 7005 7003 284541 9575 10001 2222 84246 29079 123 6256 6604 101928625 96764 7296 81857 183 5244 6095 8800 8841 406 57761 80205 1490 9412 400569 10891 9862 90390 9612 9611 10498 85441 79718 51586 1374 10499 5465 8463 336 2101 6907 1024 27063 5469 55588 5468 1376 27242 376497 51003 9477 26230 948 335 51129 211 23179 9971 23097 116519 8648 23389 4801 9282 10413 4802 112950 4800 54797 2033 19 6667 892 50486 10025 9968 133522 9969 1387 6837 2168 55090 9439 25937 9443 9441 9442 34 8202 3992 2180 6822 9440 25942 9572 4862 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%REACT_160122.2 Activation of NIMA Kinases NEK9, NEK6, NEK7 91754 9133 983 891 10783 5347 140609 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%REACT_27215.3 MyD88 cascade initiated on plasma membrane 5604 5605 7311 3569 3570 9261 3656 23118 51295 7336 1845 5781 1848 3654 1849 6288 466 1846 2353 7100 10454 100996792 7316 246330 64127 5608 983 7867 6285 4791 5598 177 5599 1660 7334 7335 1147 6283 6233 7189 5606 9252 4214 7297 1385 5601 57161 5602 10392 1386 51135 57162 3146 2002 8767 1432 4615 257397 5519 3725 6416 5518 4205 351 5515 5516 4208 3717 3716 5595 5600 5528 8517 6195 6197 7314 6196 81793 5970 4792 5594 4793 5609 4790 6885 3551 ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME%REACT_15511.1 Enzymatic degradation of Dopamine by monoamine oxidase 1312 4128 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME%REACT_12541.2 NOSTRIN mediated eNOS trafficking 115677 857 4846 1785 8976 TOXICITY OF BOTULINUM TOXIN TYPE G (BONT G)%REACTOME%REACT_200743.2 Toxicity of botulinum toxin type G (BoNT G) 6843 6844 6857 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME%REACT_21310.2 Phospholipase C-mediated cascade 5581 5582 112 115 5335 114 111 5577 5137 113 196883 814 5136 5576 5573 5568 5580 5567 5566 3710 5575 5578 801 152831 2264 805 156 9965 808 1385 3708 3709 26281 107 108 109 5153 2247 2246 2249 2255 8823 27006 2251 2252 2254 2248 8817 8074 SODIUM PROTON EXCHANGERS%REACTOME%REACT_19314.1 Sodium Proton exchangers 6548 389015 84679 285195 6549 6550 23315 10479 6553 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_20563.3 Activation of NMDA receptor upon glutamate binding and postsynaptic events 801 805 808 1385 88 816 817 2902 818 10142 2904 815 2892 2891 5923 2905 101060747 107 5924 2906 3265 2903 109 5170 2893 6237 1742 114 673 6195 6197 6196 2890 4747 814 5568 5567 5566 5594 84254 27330 5894 SIGNALLING TO ERK5%REACTOME%REACT_12020.2 Signalling to ERK5 5607 5598 GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_115896.1 GRB7 events in ERBB2 signaling 3084 2886 9542 2064 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME%REACT_705.3 PP2A-mediated dephosphorylation of key metabolic factors 5519 5528 5518 5515 51085 5516 5207 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%REACT_6237.4 RNA Pol II CTD phosphorylation and interaction with CE 728340 1022 2968 2967 5438 5439 5436 8731 902 8732 5437 5434 5435 5431 5433 5430 5432 2962 5440 2963 6829 5441 4331 2068 2071 2965 2966 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_9003.1 SCF(Skp2)-mediated degradation of p27 p21 5711 5710 1017 5714 5713 5719 9134 898 6500 5715 5716 5701 7311 5696 5687 1026 5695 5700 1163 5694 5717 5718 5688 5689 1027 8454 8900 6502 5720 7316 10213 5698 890 5699 5721 6233 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 5686 5685 5682 9861 9491 5684 5683 SIGNALING BY NGF%REACTOME%REACT_11061.7 Signaling by NGF 3066 393 5603 3065 10276 6610 53358 25759 1398 7410 89846 23263 7074 7204 8503 26052 1894 29 8874 7409 6300 25791 101927057 9459 3708 3709 1432 5519 5518 5515 5516 1211 5584 23112 5153 5595 5600 5528 6195 6197 6196 4914 5970 4792 4099 2889 1399 84894 4790 3551 160 5125 163 161 5046 5045 100507472 4803 2549 5291 5293 3569 3667 2534 5728 3570 117145 79109 5290 9261 4343 23421 6774 5781 1173 1175 5136 3164 57142 6456 3710 100505585 6464 7529 5900 5898 5899 107 108 4915 109 135 117 116 1759 10018 26574 27327 23385 6199 3815 2932 5581 23035 5582 572 5604 5605 2064 1950 7311 1026 1785 3265 5879 145957 2931 1027 1956 2309 5156 5607 8660 112 1845 6014 10126 115 5335 1848 3654 114 57498 11108 1849 6016 466 111 5137 113 1846 2069 26523 23229 5155 196883 814 7316 7249 5580 983 7867 2475 5598 8878 1839 3932 5599 23239 842 1147 50852 6233 5578 5894 7189 253260 801 805 156 808 7297 1385 940 3084 685 942 941 3845 84335 64223 4893 101060747 26281 3717 10818 4193 9542 8841 930 5170 5159 57761 10718 2247 2246 2249 2255 8823 673 27006 2251 2252 2254 7314 2248 8817 8074 5594 6868 27161 83464 51107 8997 26230 11214 57449 10451 64857 5577 5906 5664 5576 5573 5568 5567 5566 9138 5575 2245 152831 835 55851 2264 9252 9965 221472 27018 387 4804 27237 7531 836 57690 23365 6453 2002 8767 4615 9500 4205 101927462 4208 5924 5296 192669 3716 4168 6654 5295 10000 396 192670 207 9181 208 2308 121512 9828 101930241 50649 6655 4974 84033 9826 23370 50650 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_163874.2 Non-integrin membrane-ECM interactions 100500840 3371 59277 10319 3655 4921 375790 9378 7040 1605 9672 3339 3912 6382 6385 3690 3685 87 7057 3915 6383 284217 5154 8573 3691 2247 1756 7448 3918 3688 3914 3911 3910 3913 5155 645832 3908 3909 3673 51399 7276 780 100616237 3693 5578 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME%REACT_17062.1 Beta-oxidation of very long chain fatty acids 3295 215 1384 10005 30 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_150331.2 Molecules associated with elastic fibres 100505984 3696 3694 7040 8516 8200 3690 3685 2202 8425 4052 4054 4053 2199 2192 8076 10516 4236 4237 7448 30008 4238 4239 3688 652 655 27302 645832 650 7043 7042 3693 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_25031.1 GABA B receptor activation 2785 2786 2783 3760 3761 2784 2787 2788 100996843 3759 55970 107 108 54331 2793 109 2771 2792 2790 2770 3768 3766 100134444 112 3763 115 3765 114 2782 3772 94235 9568 3773 3762 111 2774 113 346562 2550 196883 2773 MULTIFUNCTIONAL ANION EXCHANGERS%REACTOME%REACT_19357.1 Multifunctional anion exchangers 10861 115019 5172 1836 1811 65010 115111 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_23810.1 Calnexin calreticulin cycle 23193 811 5589 2923 80267 821 55757 56886 11253 55741 9695 FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME%REACT_9484.3 FGFR1c and Klotho ligand binding and activation 8074 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%REACT_15381.1 p130Cas linkage to MAPK signaling for integrins 2243 54518 7450 9564 5747 5908 5906 2335 2266 3690 1398 2244 3674 7094 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME%REACT_19189.3 Synthesis, secretion, and deacylation of Ghrelin 590 9314 619373 60559 7941 2688 3952 2641 28972 5122 23478 9789 3479 90701 3630 43 SIGNALING BY HIPPO%REACTOME%REACT_118607.3 Signaling by Hippo 92597 23286 1856 51421 7531 9113 55233 836 10413 261734 7529 154810 25937 6788 6789 9414 7082 60485 26524 LAMININ INTERACTIONS%REACTOME%REACT_169262.2 Laminin interactions 3691 10319 3918 3655 3688 3914 3911 3910 22795 3913 4811 3339 3912 3908 3909 3675 3679 3672 3685 3915 3673 80781 284217 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_6785.1 Autodegradation of Cdh1 by Cdh1:APC C 5711 996 5710 5714 5713 7324 5719 5715 5716 5701 7311 5696 5687 5695 5700 730268 5694 51433 5717 5718 5688 5689 11065 51343 29882 246184 8697 29945 5720 7316 10213 51529 5698 5699 5721 10393 6233 51434 10197 5707 5706 5709 5708 5690 5705 7321 5691 64682 5704 7314 5692 5693 5702 8881 5686 5685 5682 9861 9491 5684 5683 RETINOID CYCLE DISEASE EVENTS%REACTOME%REACT_160130.2 Retinoid cycle disease events 6017 5956 101060233 5947 611 2652 728458 7276 5950 64220 222236 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%REACT_22394.1 Synthesis of UDP-N-acetyl-glucosamine 6675 64841 2673 9945 5238 POU5F1 (OCT4), SOX2, NANOG REPRESS GENES RELATED TO DIFFERENTIATION%REACTOME%REACT_200670.2 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 5460 6657 79923 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_120999.2 Signaling by FGFR1 mutants 8805 7750 11116 1523 26281 6777 5290 6776 6772 399687 5295 2247 2246 2249 6774 613 5335 9208 2251 9846 2254 2260 8074 11052 26127 ADAPTIVE IMMUNE SYSTEM%REACTOME%REACT_75774.4 Adaptive Immune System 10235 28442 5062 9666 28454 9520 3093 401036 8139 51444 6049 25847 26232 255488 27252 6047 136371 5071 26118 89910 23608 51465 90678 8503 79654 9817 51343 142689 26052 11059 9690 197131 55284 142685 6502 142686 55585 7409 642 7704 151636 29127 127544 28908 9039 997 26273 55070 4012 101929832 122769 9903 92591 126433 10425 80176 64320 26259 4591 115290 54926 22888 3693 10533 51619 7412 3695 3383 3676 1211 10112 3384 3385 3386 23112 3683 9493 8915 84433 8517 10125 5579 23291 5966 10892 2210 2209 28834 5970 4794 4792 4793 4790 25780 6885 3551 996 2214 7324 991 28916 1062 28912 1535 1536 3796 730268 653361 51433 718 7318 4689 4688 11065 81930 29882 100847079 8697 28299 29945 84643 51529 3538 6396 10393 9246 1520 100302652 23352 3539 9320 140739 80196 9730 79876 55182 51626 8924 84516 63891 100423062 10120 27338 63893 1514 64219 3812 1513 3802 23304 3542 84727 80329 3689 7529 4277 9354 100653050 148581 3821 114088 1515 3811 7317 1508 4345 65264 3514 10075 10225 7319 1075 55176 10219 7325 7534 7320 114876 25898 28776 644076 51676 101929809 101929047 79465 51130 28876 7879 79754 56253 101930157 83547 51665 79659 51666 100507436 51434 10288 28874 9867 11126 10477 140462 11024 7337 1780 7326 11004 131450 11025 1759 81559 1783 7174 7327 10671 7332 1510 1519 55521 64682 7328 11006 118424 1512 8722 93611 959 127247 975 23295 10666 221687 972 28896 90293 27327 3108 8881 3109 140735 3112 140456 3111 140459 10859 925 92369 10870 140458 2213 3799 84676 135250 10489 51164 10616 727787 55236 140461 10990 55958 3798 5476 140460 440786 92912 6199 9402 3815 7305 23035 7322 572 3810 2064 3805 9040 1950 3808 1026 3804 6850 3806 3803 3265 5879 145957 2931 1027 1956 3809 64750 2309 5156 3797 3937 8660 6737 22920 22914 5335 3832 5336 22954 3835 100500810 100132285 3831 9371 2069 26523 695 3133 5155 11127 3824 285643 26153 7249 56992 2475 3107 3106 1839 89953 3932 23239 842 1147 1326 50852 5894 973 253260 974 640 100528032 27071 100133046 940 6725 3084 685 942 941 118788 7220 3507 821 29760 3495 868 100996743 9902 4360 3845 50489 84335 64223 4893 101060747 4193 3105 9542 930 5170 5159 57761 100132417 10718 101928757 3135 8519 3134 57154 51128 100996919 5906 30011 2923 23327 55824 22872 6402 6891 6890 64167 101927462 6892 9871 51752 6654 7428 8453 998 120425 1525 5817 5819 54778 999 10193 5908 5909 23108 6494 1493 83737 151888 6786 9020 8764 5133 23308 3708 80380 3709 29126 10273 5519 8907 5518 8905 5515 5516 84876 5529 7408 5528 5527 5525 3688 8065 8452 10053 5526 9021 1445 160 164 10411 163 162 161 2549 5291 5293 567 3667 2534 5728 117145 79109 5290 4343 5781 1174 1173 5788 1175 375 5777 3164 6456 3710 10802 10427 130340 4734 64837 147700 24137 11069 6921 6923 10484 5641 5711 3115 5710 100509457 5714 3117 28577 5713 3119 5719 3118 916 8945 915 2932 3702 10437 5063 23198 7454 27040 100507709 6500 5715 55740 5716 3113 51466 4690 5701 7311 7525 3122 5696 5058 9632 5687 5695 5700 5588 5694 1785 917 100996809 5717 100507714 101060835 5718 5688 3120 5689 4067 2533 8454 3123 28639 23118 7336 246184 26272 5720 7535 7316 10213 5698 28755 55294 3125 3126 9978 5699 3127 8651 7334 26270 143471 7335 5721 6233 7189 801 1781 805 1778 808 1385 10121 26281 10818 8655 2247 7323 2246 2249 10197 5707 2255 10540 5706 8823 5709 27006 5708 5690 2251 5705 2252 5691 867 7321 5704 2254 7314 2248 5692 8817 5693 5702 8074 122706 6712 5686 11258 5685 5682 1509 9861 9491 5684 5683 926 27161 920 3685 10952 948 5568 9820 5567 5566 1639 152831 23480 2264 9965 57690 3309 8767 811 5296 192669 29927 5295 10000 192670 207 208 2308 3635 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME%REACT_23847.2 GP1b-IX-V activation signalling 2815 2814 2316 7534 2812 2811 7450 5295 5894 B CELL ACTIVATION%REACTOME%REACT_118773.4 B Cell Activation 28442 28454 8503 7409 28908 6786 3708 3709 84876 23112 8915 84433 8517 10125 5579 23291 5966 10892 28834 5970 4794 4792 4793 4790 25780 6885 3551 28916 28912 2549 5291 5293 3667 2534 5728 117145 79109 5290 4343 5781 28299 3164 3710 3538 3539 100423062 3542 3514 28776 28876 28874 28896 27327 440786 5711 6199 5710 5714 3815 5713 5719 8945 2932 23035 23198 572 6500 5715 5716 2064 5701 4690 7311 1950 5696 5687 1026 5695 5700 6850 5694 3265 5717 5718 145957 5688 2931 4067 5689 1027 8454 1956 2309 5156 8660 5335 5336 2069 695 26523 5155 5720 7316 7249 10213 5698 2475 5699 1839 3932 23239 842 143471 1147 50852 5721 6233 973 801 253260 974 805 808 640 27071 1385 940 6725 3084 685 942 941 118788 7220 3507 29760 3495 868 3845 84335 64223 4893 101060747 26281 10818 4193 9542 930 5170 5159 57761 10718 2247 2246 2249 10197 2255 5707 8823 5706 5709 5708 27006 2251 5690 5705 2252 867 5691 5704 2254 2248 7314 8817 5692 5693 5702 8074 122706 5686 5685 5682 9861 9491 5684 5683 27161 30011 152831 2264 9965 57690 5296 192669 6654 5295 10000 192670 207 208 2308 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_121337.2 Signaling by activated point mutants of FGFR3 2247 2261 2246 2249 8823 26281 2254 8817 8074 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_121288.2 Keratan sulfate keratin metabolism 23563 10331 11081 5549 176 10402 643853 3073 3074 8702 93010 8704 8703 9331 2331 9334 8534 4969 10678 9435 4060 2720 2799 2683 4958 4166 6482 79411 11041 6483 6487 6484 11046 79369 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_118682.2 Activation of Matrix Metalloproteinases 4314 4318 5645 1513 64386 5045 5644 1515 7076 4317 4316 4312 3818 4319 7177 7077 3817 1511 440387 1504 10893 4313 4326 5340 4325 1215 4324 4323 4320 4322 80781 1991 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_147753.2 MPS IIIA - Sanfilippo syndrome A 23563 10331 2239 3373 79586 9469 3339 126792 9653 3073 3340 3074 6383 11285 10678 9435 3038 9394 10675 3037 3036 2720 283464 8372 100616124 2719 727936 4958 9957 11041 9956 9955 633 3425 1634 3423 11046 79369 27087 9348 347734 11081 411 176 63827 6382 643853 6385 8509 8702 26035 8704 8703 9331 10855 9334 4969 10861 2262 10057 29940 2990 64579 2817 2132 2131 60495 960 55454 10082 6482 6483 6487 6484 1836 6548 135152 56548 266722 10402 51363 22856 221914 222537 93010 10090 10894 55576 2799 6448 8692 337876 26229 90161 64711 166012 11261 375790 3161 113189 5549 9951 9953 9672 1463 4669 2331 51000 8534 50515 4060 1464 9060 1462 55790 2683 92126 55501 4166 9061 79411 54480 LYSINE CATABOLISM%REACTOME%REACT_1298.3 Lysine catabolism 89874 1743 10157 4967 501 2639 1738 51166 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%REACT_11053.2 Synthesis of bile acids and bile salts via 24-hydroxycholesterol 10858 1646 80270 5740 11001 1582 6718 23600 101930400 1645 8644 1109 51302 10998 1593 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_160099.1 FBXW7 Mutants and NOTCH1 in Cancer 3066 3714 6868 3065 3280 6907 54492 1024 7089 408 409 7088 23462 6500 3091 7311 2648 8650 83464 113878 10014 51107 1272 8454 9794 26508 10013 102 84441 101928143 23493 4851 8788 5664 7316 142678 22938 9759 9978 10046 7091 54567 57534 83737 6233 51564 55851 79885 4609 9148 2033 55869 55534 182 892 8841 101930388 3516 28514 388585 83933 9734 1387 7314 9612 9611 92737 1840 8850 79718 23220 23385 FERTILIZATION%REACTOME%REACT_163914.2 Fertilization 2515 101930343 22917 11085 126123 6677 157855 113177 928 100129669 117144 84329 5016 7783 378807 117155 49 8747 8748 257062 7784 2683 284359 57829 347732 57828 79820 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME%REACT_18352.1 Eicosanoid ligand-binding receptors 56413 1241 6915 5734 5729 5732 5731 5737 57105 11251 165140 5733 2840 5739 10800 SIGNALING BY INSULIN RECEPTOR%REACTOME%REACT_498.8 Signaling by Insulin receptor 1796 29904 6198 7248 51719 81617 101930123 6794 5565 5564 5563 5562 92335 5604 5571 5605 2887 53358 3643 25759 1398 3265 54106 55437 6009 51422 57521 53632 8660 7249 983 2475 5894 7297 537 5140 3845 64223 4893 26281 101060747 10818 3717 1981 5170 57761 5595 2247 2246 2249 2255 8823 27006 2251 2252 2254 2248 8817 8074 5594 527 528 2549 526 5291 525 523 3569 9114 3667 529 3630 9296 3570 51382 117145 50617 23545 5290 10312 245973 8992 1978 245972 127124 5781 101927180 533 1977 534 1975 535 90423 51606 155066 9550 5289 6194 30849 6464 152831 2264 9965 7529 5296 3716 6654 5295 208 5494 SIGNALLING TO ERKS%REACTOME%REACT_12058.2 Signalling to ERKs 7297 5603 5604 5605 1432 4803 7529 3845 53358 5900 25759 5898 3569 4893 1398 5899 3717 10818 3265 3570 3716 6654 9261 5595 5600 6014 5781 5335 57498 673 6016 6300 5906 983 7867 4914 5594 2889 1399 6464 5894 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_964.3 Intrinsic Pathway for Apoptosis 7531 836 331 637 100422899 100422832 90427 572 7533 7532 7529 7157 1869 5366 5534 7534 3002 54205 8655 10000 840 581 598 596 56616 578 207 208 317 4836 10018 27113 5533 140735 2810 841 10971 7027 5599 842 LEADING STRAND SYNTHESIS%REACTOME%REACT_1838.5 Leading Strand Synthesis 5422 5111 5982 5981 5983 23649 5557 57804 5558 5425 5424 10714 5985 5984 TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME%REACT_202.4 Transcriptional activation of p53 responsive genes 7157 1026 ACTIVATION OF RAS IN B CELLS%REACTOME%REACT_118778.3 Activation of RAS in B cells 3845 10125 4893 3265 25780 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_798.4 Platelet activation, signaling and aggregation 391 10235 7040 1398 7410 3082 2621 8503 10672 7409 5908 5216 2776 51764 88 2791 3708 3709 1432 2767 2769 87 3479 57113 4352 7066 10681 5595 7422 928 10125 5579 5294 10487 3481 7225 7222 2316 5340 2207 1445 10411 7423 408 409 9564 2277 7424 5291 2534 7057 5660 5290 2243 2162 2 59345 710 2815 213 2814 3827 2266 5321 2153 2244 3710 5175 5590 5473 151 5627 6464 2157 5196 2785 2786 2783 2784 2787 54518 2788 6810 2812 2811 7450 2147 55970 7534 51206 54331 10257 2793 2771 2792 2790 2770 2782 2773 11069 6814 1675 1072 5581 5582 27040 5747 9630 1950 2335 6850 5588 27154 5879 4067 3937 5336 94235 346562 5155 5580 11343 3932 101060363 5894 5578 801 5478 805 808 226 101060747 7277 5170 23533 7273 150 152 5770 5594 160851 5028 5583 9002 139189 64805 7414 2768 3690 3674 146850 6915 948 335 10451 6678 5906 7043 7042 1609 1607 1608 7094 1606 221955 8527 388 8526 387 8525 747 3309 2149 5880 351 5054 5296 440915 6654 5295 7076 10000 6403 9162 5552 5265 81 3920 207 7018 208 1191 3273 813 998 7044 10637 29106 22927 6647 967 9948 5341 22915 7114 5345 2151 SIGNALING BY ERBB4%REACTOME%REACT_115596.5 Signaling by ERBB4 6199 3815 8945 2932 23035 572 6500 5604 5605 2064 1950 7311 1026 3265 145957 6777 2931 1027 8503 1956 8454 2309 11059 23118 5156 8660 7409 2069 26523 5155 7316 7249 983 6285 2475 9978 1839 3932 23239 842 1147 50852 6233 83737 5894 253260 7297 1385 940 3084 685 942 941 3845 84335 64223 4893 26281 101060747 3717 10818 4193 9542 930 5170 5241 5159 23112 57761 10718 5595 1443 1444 2247 51741 2246 2249 2670 2255 6387 2690 8823 2689 2688 27006 2251 2252 2254 7314 2248 8817 8074 9611 5594 5618 1447 1442 6868 2099 2549 5291 5293 27161 3569 83464 3667 2534 51107 5728 3570 117145 79109 5290 4343 5781 5664 3164 6464 152831 55851 2264 9965 57690 10413 7529 5617 5296 192669 3716 6776 6654 5295 4734 10000 192670 207 208 2308 27327 23385 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_169436.2 Oxidative Stress Induced Senescence 8335 8334 653604 8337 1019 8331 255626 7311 8358 333932 8352 8359 8353 8354 8338 8339 2353 26523 474382 8357 100996792 8356 8347 7316 8348 8345 5608 7867 8346 8340 7027 5599 8343 8344 8341 6233 8342 3021 3020 85236 8726 8968 8360 8362 8361 7295 8364 54145 1432 8363 57332 8365 50488 8366 80012 8970 8368 6045 1911 8349 8550 8367 648 100616282 1912 5928 23466 4193 8351 84733 6015 9448 8350 4217 23112 8535 8355 23043 5595 3013 5600 3012 723790 126961 8294 7314 5931 554313 121504 3015 3014 8370 5594 3018 3017 23512 1030 128312 1871 1870 4343 9261 5606 2146 5601 5602 57690 7157 1869 6416 3725 1021 192669 1029 192670 1031 1032 23135 27327 3456 5609 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_13621.1 HDL-mediated lipid transport 3931 213 19 1071 335 2 345 81693 348 8029 9619 344 S6K1-MEDIATED SIGNALLING%REACTOME%REACT_6754.1 S6K1-mediated signalling 29904 6198 6194 64223 2475 101930123 1975 1981 6009 57521 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_169440.2 TGFBR2 Kinase Domain Mutants in Cancer 1030 1875 1874 3065 1025 1024 7048 56288 7046 60436 5045 7040 54778 9040 56937 7311 100527943 11171 142 904 51377 57154 23645 905 64750 7029 2280 4088 7316 4089 9110 9958 5590 7027 57530 5499 6233 4087 25805 23327 4609 50855 387 4221 10273 7050 6667 51592 6497 50848 5054 6498 892 4092 7323 3726 7321 5500 867 5501 7314 9612 9611 25937 8239 5933 4738 101929368 23370 5494 7514 ATP SENSITIVE POTASSIUM CHANNELS%REACTOME%REACT_75775.2 ATP sensitive Potassium channels 3767 6833 10060 3764 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME%REACT_9020.4 Toll Like Receptor 7 8 (TLR7 8) Cascade 5604 5605 7311 3569 3570 54106 9261 3656 23118 51295 7336 1845 5781 1848 3654 51284 1849 6288 466 1846 2353 10454 100996792 170506 3665 7316 246330 64127 5608 7867 983 6285 4791 5598 177 5599 1660 7334 7335 1147 51311 6283 6233 7189 5606 9252 7297 4214 1385 5601 57161 5602 10392 1386 51135 57162 3146 2002 8767 1432 4615 257397 5519 3725 6416 5518 4205 351 5515 5516 4208 3717 3716 5595 5600 5528 8517 6195 6197 7314 6196 5970 4792 5594 4793 5609 4790 6885 3551 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME%REACT_1830.1 Attachment of GPI anchor to uPAR 5329 80055 51604 8733 94005 128869 10026 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME%REACT_1473.1 Mitochondrial Fatty Acid Beta-Oxidation 1892 166785 5095 4594 5096 3033 3032 3030 35 1666 33 34 37 84693 1632 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME%REACT_22426.4 Asparagine N-linked glycosylation 9632 2720 4759 4758 79644 1650 5589 821 338596 11320 643853 25834 10559 2673 8702 8704 8703 9331 4249 51046 11282 29880 9334 6480 8818 11253 9695 6482 6483 6487 6484 27090 80267 55757 56886 10402 55741 79087 54187 440138 64841 55808 79868 5372 7841 5373 51128 4351 57171 7991 144245 9945 29906 199857 10825 1798 55907 8869 10610 1603 79947 3703 81849 29929 22845 84061 30815 23193 54344 84920 6675 129807 84620 386724 91869 10020 100507589 140838 79796 4597 8813 79053 85365 29925 9526 10802 2923 29926 10427 6396 9761 6489 80896 10195 5238 56052 8128 4248 7903 3998 26503 22872 811 9871 6185 256435 6184 2683 4247 57134 10113 10905 90411 79694 4122 4121 4124 2530 10484 4245 5476 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_160102.4 Diseases associated with visual transduction 336 337 2239 121214 26020 3949 9249 83875 3339 51109 6295 2779 10988 221914 9397 2979 101060233 2978 5588 5158 2652 6383 2339 23173 345 2342 64220 388531 348 9626 10170 5145 3292 100529261 344 9227 335 5957 338 2986 6010 6011 1258 5148 1259 3000 2719 4836 5475 57016 6121 1645 145226 29967 50700 101927965 7804 5578 6017 801 805 808 5956 5959 4036 375790 728458 4035 222236 4023 9672 6382 151056 6385 5948 611 5947 5949 5950 8644 1109 2792 1208 24 2262 9187 2782 2817 4647 8630 157506 10082 5406 7276 8608 53630 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_200833.2 Glycogen storage diseases 10331 3099 3098 126792 3073 3074 55746 2538 2539 3038 9394 8972 3037 3036 2720 11181 2719 727936 4958 3425 1634 3423 9348 63827 8908 5519 5518 6527 5515 5516 8509 8702 7175 9883 8704 8703 9331 9334 4969 6515 2997 5528 6513 2998 10057 29940 2990 64579 2817 2132 2131 5106 5105 23225 960 55454 6888 7360 6476 10082 6482 6483 6487 6484 55276 1836 2992 2023 135152 51363 5223 5224 5226 2203 10894 5230 200010 55576 8402 6448 8789 23165 337876 23279 90161 79902 26330 22934 64711 375790 5549 1463 129401 4669 51000 8534 50515 7957 4060 5507 9060 9688 55790 7086 2683 9972 92126 55501 9061 54480 3938 23563 8604 2239 221823 3373 79586 2646 9469 3339 7311 9653 3340 92579 4191 6383 11285 4190 10165 10678 9435 378884 10675 3795 2632 283464 8372 100616124 7316 6120 9957 11041 9956 9955 633 2806 2805 11046 6233 79369 801 27087 805 5255 808 5256 347734 5257 11081 5214 229 226 411 176 178 6382 643853 5236 648740 6385 8021 26035 10855 2821 10861 2262 3101 60495 7314 5213 5210 11097 5208 5207 6518 23511 5211 23636 5209 25796 6548 277 278 56548 276 2542 266722 10762 10402 280 22856 221914 5903 222537 93010 5837 5834 10090 279 5836 8480 6576 6517 5260 2799 57818 8692 5568 5567 6523 5566 6526 6524 26229 5261 230 5091 348995 5634 7167 166012 9631 11261 3161 113189 53371 2027 2026 9951 9953 4927 9672 2597 8086 2331 2584 2582 6514 1464 2592 5631 1462 1468 2645 4166 57122 79411 79023 REGULATION BY C-FLIP%REACTOME%REACT_164011.2 Regulation by c-FLIP 8717 841 8743 355 7186 8772 356 8737 8795 EXTENSION OF TELOMERES%REACTOME%REACT_8030.5 Extension of Telomeres 5422 8607 5427 23649 5557 57804 5558 3978 10714 5111 5982 5981 5983 2237 7015 6119 6118 6117 5426 5425 100847052 5424 5985 1736 5984 1763 55135 10856 55651 677835 HIV ELONGATION ARREST AND RECOVERY%REACTOME%REACT_6259.5 HIV elongation arrest and recovery 1025 5438 100126332 5439 5436 5437 5434 5435 8178 5431 5433 904 5430 905 5432 6749 2962 7469 5440 2963 100302242 6829 25920 5441 11198 6827 7936 9150 6921 6924 6923 6917 51497 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME%REACT_1006.7 Polo-like kinase mediated events 995 9133 9088 891 2305 1063 7465 2033 4605 5928 91750 55957 286826 132660 993 5347 PLC-GAMMA1 SIGNALLING%REACTOME%REACT_12079.2 PLC-gamma1 signalling 801 156 805 808 1385 5581 5582 3708 3709 4803 107 108 109 5153 112 5335 115 114 111 5577 5137 113 196883 814 5576 5136 5573 5568 5567 5580 5566 3710 4914 5575 5578 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_120966.2 Gastrin-CREB signalling pathway via PKC and MAPK 10235 8503 7204 2776 51764 2791 3708 3709 2767 2769 57113 10681 5595 10125 6195 6197 6196 7225 7222 2922 3569 3570 5290 5781 59345 3827 3710 2785 2786 2783 4314 2784 2787 5330 2788 5332 2147 5331 7529 55970 54331 2793 2792 2790 2782 5581 5604 3269 9630 5605 553 5020 5588 552 3265 1956 2864 94235 5580 983 5598 11343 1839 23236 5894 5578 156 7297 1385 2641 2642 183 3845 4893 3062 3717 5594 160851 5028 5583 9002 846 1241 57121 3814 1133 431704 3358 27334 84109 3357 2846 2915 139189 2911 60675 84432 5029 10161 84634 115557 9170 2796 128674 185 3356 2828 2829 10287 10886 10316 624 10800 2798 2797 94233 23620 10887 2867 8997 6863 2865 8477 6915 347148 3061 2869 6288 257313 23566 2693 5724 5997 2862 3060 57105 387129 29933 2520 146 147 5031 148 5032 2925 551 2840 64106 594857 1609 1607 1608 6846 1606 8620 221955 680 8527 2150 886 885 8526 8525 6865 6866 6869 747 6870 2149 5731 5737 351 5296 2358 301 3716 6654 5295 6375 9162 56413 623 10874 129521 2837 5021 1128 7201 7200 1910 1131 56923 64407 1908 2847 10911 1906 5367 1907 1909 222545 8111 1902 4295 4828 4829 4922 114814 887 84539 2151 4923 AGMATINE BIOSYNTHESIS%REACTOME%REACT_14800.3 Agmatine biosynthesis 113451 79814 FCGR ACTIVATION%REACTOME%REACT_160274.2 FCGR activation 2212 101930374 3539 2214 28916 28442 100423062 2268 28454 3542 28912 7525 3514 6850 2534 28776 3502 917 3503 28876 4067 3501 28874 3055 28908 28299 28896 2210 2209 28834 3538 440786 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME%REACT_18365.1 Lysosphingolipid and LPA receptors 9294 53637 9170 57121 1902 1903 23566 1901 8698 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_147749.2 MPS IIID - Sanfilippo syndrome D 23563 10331 2239 3373 79586 9469 3339 126792 9653 3073 3340 3074 6383 11285 10678 9435 3038 9394 10675 3037 3036 2720 283464 8372 100616124 2719 727936 4958 9957 11041 9956 9955 633 3425 1634 3423 11046 79369 27087 9348 347734 11081 411 176 63827 6382 643853 6385 8509 8702 26035 8704 8703 9331 10855 9334 4969 10861 2262 10057 29940 2990 64579 2817 2132 2131 60495 960 55454 10082 6482 6483 6487 6484 1836 6548 135152 56548 266722 10402 51363 22856 221914 222537 93010 10090 10894 55576 2799 6448 8692 337876 26229 90161 64711 166012 11261 375790 3161 113189 5549 9951 9953 9672 1463 4669 2331 51000 8534 50515 4060 1464 9060 1462 55790 2683 92126 55501 4166 9061 79411 54480 S6K1 SIGNALLING%REACTOME%REACT_6772.1 S6K1 signalling 29904 6198 6194 101930123 1975 1981 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_19388.4 G-protein beta:gamma signalling 2785 2786 51764 2783 2784 387 2787 2788 5330 2791 5331 55970 101060747 54331 2793 10681 5170 2792 2790 23533 10000 146850 59345 207 2782 208 94235 5294 23236 CARNITINE SYNTHESIS%REACTOME%REACT_2125.4 Carnitine synthesis 8424 55217 6470 223 TOXICITY OF BOTULINUM TOXIN TYPE B (BONT B)%REACTOME%REACT_200782.2 Toxicity of botulinum toxin type B (BoNT B) 127833 6844 6857 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%REACT_111174.1 Cross-presentation of particulate exogenous antigens (phagosomes) 1535 1536 948 653361 3685 3693 4689 4688 G ALPHA (S) SIGNALLING EVENTS%REACTOME%REACT_19327.3 G alpha (s) signalling events 1081 10203 79924 3274 6019 9038 9340 4158 112 4160 5734 115 4161 114 5732 94235 111 113 346562 4157 196883 2695 4159 796 3640 59350 51764 2740 2791 2641 2642 5140 5138 5150 5139 8622 136 133 117579 2778 27115 10681 5151 5153 10846 5142 3973 5141 2492 5143 2488 5144 7253 2692 2691 9288 9287 2696 1816 1812 3360 3362 3363 799 797 83551 2781 59345 387129 155 5136 151306 5032 551 153 554 154 594857 5739 50940 7252 2785 2786 7432 2783 7433 7434 2784 2787 2788 122042 5443 55970 10268 107 108 54331 6343 10266 2793 6344 10267 109 135 2771 5746 5741 2792 117 2790 5744 116 2770 5745 1392 1395 1394 113091 5729 2782 3375 729966 134860 134864 319100 2773 3972 AMYLOIDS%REACTOME%REACT_75925.2 Amyloids 8335 337 8334 653604 8337 7045 8331 255626 3339 567 9445 128312 3630 4057 8358 2243 333932 8352 8359 6622 335 8353 8354 6288 8338 8339 2934 474382 8357 8356 796 8347 8348 8345 54959 8346 8340 4878 8343 8344 8341 8342 3021 3020 85236 8968 8360 8362 8361 8364 54145 8363 6406 8365 8366 8970 8368 8349 351 8367 100616282 5617 4069 8351 8350 8355 3013 3012 1471 3375 723790 126961 8294 325 554313 121504 3015 3014 7276 8370 3018 3017 4240 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME%REACT_735.3 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 1892 33 3033 3032 3030 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_160082.2 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 3066 3714 6868 3065 3280 6907 54492 1024 7089 408 409 7088 23462 6500 3091 7311 2648 8650 83464 113878 10014 51107 1272 8454 9794 26508 10013 102 84441 101928143 23493 4851 8788 5664 7316 142678 22938 9759 9978 10046 7091 54567 57534 83737 6233 51564 55851 79885 4609 9148 2033 55869 55534 182 892 8841 101930388 3516 28514 388585 83933 9734 1387 7314 9612 9611 92737 1840 8850 79718 23220 23385 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_24918.3 IRAK1 recruits IKK complex 246330 7336 8517 3654 57161 57162 7334 7335 1147 3551 7189 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_118563.3 RIP-mediated NFkB activation via ZBP1 8517 6288 148022 81030 11035 3146 8737 4615 6285 351 4791 7098 5970 177 4792 4793 1660 4790 1147 6283 3551 FIBRONECTIN MATRIX FORMATION%REACTOME%REACT_160131.2 Fibronectin matrix formation 2335 3678 3688 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME%REACT_22285.1 Transport of vitamins, nucleosides, and related molecules 11309 55315 347734 6578 84912 28965 53919 9154 2030 9153 55343 10559 3177 222962 376497 353189 10999 51000 23443 8884 7355 9197 10599 64078 100616124 213 28231 23169 28234 51248 551 11046 6579 NETRIN-1 SIGNALING%REACTOME%REACT_22237.1 Netrin-1 signaling 4651 59277 7430 1793 7220 5747 8976 4756 4690 90249 219699 5588 2534 57113 5879 9423 7204 5306 5781 6091 1630 5335 9353 998 22885 3983 7225 84448 7222 137970 8633 285704 7223 6478 7224 148738 56963 116986 6586 6585 6477 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_19184.3 GPCR downstream signaling 219437 6002 391 219417 393 219436 2914 283365 2913 2912 219429 10276 219432 126541 219431 6000 219438 6001 122740 122742 122748 346517 79290 79295 79296 219428 7410 50839 26184 89846 346528 346525 23263 6019 7074 125958 7204 9340 219869 219469 79274 1894 219482 5734 29 219484 8874 7409 5732 2920 219875 219873 219874 219464 219870 25791 2921 219447 219865 119687 119682 219858 219473 219477 219479 2918 119679 3640 119678 2917 2780 219453 2919 2916 390431 390432 390437 5364 390038 390433 120586 5368 390445 390037 390036 390442 390441 26189 50838 50837 26188 50836 10125 341152 5579 50840 441608 50832 50833 50834 50835 50831 284433 441639 119694 347468 390429 119695 390538 119692 1815 1816 1813 1814 1812 390436 390439 8590 56656 504190 391107 391109 135941 504191 2922 135948 135946 401427 391114 391112 121275 504189 81127 390651 26533 26532 26539 26538 284521 26531 56670 134083 391121 135924 26529 441670 441669 127623 6364 6363 8601 120065 120066 6366 6752 6753 2841 6360 6751 390323 390321 6750 155 3827 151306 6352 153 154 151 2852 26707 5196 81168 127608 79346 442185 442186 442184 81169 26595 128366 128367 128368 2147 79345 143496 5443 128360 51083 79339 79334 402135 5733 81193 219487 79324 219493 442179 127617 5746 5741 5744 5745 1392 1395 1394 4283 5729 5726 284532 26534 7932 283869 729966 134860 134864 26575 256933 128372 128371 144125 144124 79310 79317 392133 125962 392138 125963 10563 9294 1081 347169 401667 9290 219965 219960 347168 81797 5581 219986 119772 5582 119774 401665 401666 401663 150681 81282 286365 79470 65944 81697 81696 2652 81285 219957 219956 5879 219959 219958 79473 256892 219968 53637 4158 4543 4544 4160 4161 388761 441911 26692 26693 26696 4157 4159 254786 254783 1269 10803 1268 26686 255725 11343 286362 26658 26659 26664 343406 283093 23236 283092 186 156 26716 187 2826 2833 2832 2831 6372 6370 6374 2641 6373 2642 23538 390326 390327 8622 136 611 133 81300 101060747 3062 134 117579 138799 5170 10850 341276 6754 6755 127066 127068 127069 219952 81309 140 127062 127064 390649 390648 196335 81315 127077 127074 219983 9288 219981 219982 119764 119765 9287 338662 338675 338674 389090 119749 127059 219954 9628 100996542 160851 4995 5583 4994 9002 340980 846 1241 392390 57121 392391 3814 10798 387748 1133 431704 343171 84109 343173 2915 343172 81431 139189 2911 343169 339403 60675 84432 158131 392376 84634 115557 2768 9170 2796 283160 128674 81406 259287 185 283159 2828 259289 2829 259286 10287 799 10886 10316 797 83551 624 10800 259285 2798 259296 2797 259291 23620 2781 259295 10887 8997 259293 146850 2867 6863 259292 283162 2865 259294 8477 26230 390271 6915 11214 259290 347148 3061 57449 390275 2869 10451 390265 257313 64857 58191 23566 2693 390261 5724 390264 138881 5997 390260 2862 3060 390266 57105 138882 387129 138883 283111 29933 2520 283110 392392 146 120793 147 120796 148 9138 2925 353164 64106 390199 594857 390197 1609 390195 1607 81392 1608 4889 6846 1234 4886 1606 4887 8620 81399 221955 7252 81228 2245 680 7432 8527 10022 2150 7433 221472 886 7434 388 885 8526 387 27237 26689 8525 26687 6865 389 26211 6866 26212 23365 6869 341799 747 6453 441932 6870 5880 441933 2149 26682 5731 285659 5737 26683 81248 26219 1237 1233 1236 5697 1232 5924 26248 121129 6343 6344 1230 121130 4168 26245 6654 8698 120776 6375 120787 9162 729759 56413 120775 623 26648 10874 26246 129521 653166 2837 1128 9181 51289 7201 998 719 7200 1910 390201 1131 56923 338398 64407 27199 1908 728 121512 127385 2847 10911 319100 1906 9828 4993 4992 5367 1907 4991 1909 8484 101930241 165140 222545 8111 1902 283189 50649 4295 6655 138805 84033 4828 3972 9826 138804 4829 23370 138803 4922 50650 138802 114814 4987 887 84539 7852 4988 4985 2151 4986 4923 390058 390059 390054 390053 10203 79924 390154 390155 390152 390151 442361 390157 390162 390167 390168 390134 3579 3577 393046 11251 101060233 390142 79541 643 79544 390144 79549 390148 403284 9038 403282 10672 390113 100996758 8388 8387 8383 8386 8391 8390 8389 8392 283694 130075 796 283297 162998 8811 10636 390883 390894 3576 390892 10663 282775 282763 390882 59350 2776 391189 8862 282770 79501 391195 391196 391190 391192 9459 391191 2740 728458 124538 8786 8787 391194 57007 5999 5996 5150 26740 26338 26339 2767 283617 2769 56477 402317 26333 1132 26737 27115 1129 5151 26735 26341 54429 5142 254879 5141 5143 343563 5144 2692 5294 81318 81328 2691 5539 5173 5179 338755 4852 81341 442194 442197 442191 27198 81327 338442 2696 8843 126370 390174 390191 390190 390181 338751 26494 26493 26496 26495 441308 26492 26476 391211 100505585 5473 85397 26497 341416 341418 79482 403253 403257 81472 5956 143503 81061 1903 122042 143502 1901 256144 341568 256148 121364 81458 401973 403278 403277 79490 10268 403273 81469 403244 10266 10267 81470 403239 81466 390083 390084 2587 113091 3627 81442 81448 81050 401993 401994 401992 390093 254973 403274 390061 81099 390063 284383 390066 390064 390081 390067 390078 390077 390073 390075 390079 390072 390082 392309 9630 2779 5588 2864 6010 183 23533 150 152 3973 2492 7253 551 554 10235 729230 8503 1235 727 718 5330 5332 5331 553 5020 552 5580 5578 6387 5028 5030 27334 2846 53829 9934 64805 5029 10161 5031 5032 2840 5021 51764 2791 3708 3709 5140 5138 5139 57113 2778 10681 5153 10846 2488 7225 7222 5290 59345 5136 3710 5739 50940 2785 2786 2783 2784 2787 2788 55970 107 108 54331 2793 109 2771 135 2792 117 2790 116 2770 2782 9568 2774 2550 2773 9475 6093 59340 3274 11255 3269 112 115 114 94235 111 113 346562 23229 196883 2695 23596 3354 3358 3357 3350 3360 3361 3362 3363 3352 3356 3351 3355 5995 221391 94233 10692 6288 351 5296 2358 2359 301 2357 50865 5295 10000 207 208 3375 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_169219.2 Loss of Function of SMAD4 in Cancer 1030 1875 1874 3065 1025 1024 7048 56288 7046 60436 5045 7040 54778 9040 56937 7311 100527943 11171 142 904 51377 57154 23645 905 64750 7029 2280 4088 7316 4089 9110 9958 5590 7027 57530 5499 6233 4087 25805 23327 4609 50855 387 4221 10273 7050 6667 51592 6497 50848 5054 6498 892 4092 7323 3726 7321 5500 867 5501 7314 9612 9611 25937 8239 5933 4738 101929368 23370 5494 7514 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME%REACT_257.2 Formation of incision complex in GG-NER 728340 1022 2968 2967 7507 7508 6119 902 6118 4331 5887 6117 2067 1643 2068 2071 2073 1642 2072 2965 2966 FORMATION OF HIV ELONGATION COMPLEX IN THE ABSENCE OF HIV TAT%REACTOME%REACT_22201.3 Formation of HIV elongation complex in the absence of HIV Tat 728340 1022 2968 2967 1025 5438 100126332 5439 5436 902 5437 5434 5435 8178 5431 5433 904 5430 905 5432 22916 2962 6749 2963 7469 5440 6829 100302242 25920 5441 11198 4331 4686 6827 7936 2068 9150 2071 6921 6924 6917 6923 2965 51497 2966 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_115828.2 Downregulation of ERBB4 signaling 11059 7311 7316 7314 6233 4734 83737 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME%REACT_1041.2 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components 11065 51434 996 7324 9184 991 29882 7321 64682 246184 8697 29945 4085 8881 51529 730268 51433 701 10393 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME%REACT_20647.2 Thromboxane signalling through TP receptor 2785 10672 2786 51764 2783 6915 2784 2787 59345 2782 2788 94235 2791 9630 55970 2767 2769 54331 2793 10681 2792 2776 2790 SIGNALING BY HEDGEHOG%REACTOME%REACT_228134.1 Signaling by Hedgehog 5711 5034 5710 5714 6868 5713 5719 23198 5715 5716 5701 7311 5696 7415 5687 5695 5700 6469 5694 5717 5718 5688 5689 3549 5720 7316 10213 5698 5699 143471 5721 6233 6400 51009 27248 50846 147111 2262 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 122706 84447 5686 5685 55733 5682 85455 9861 57758 9491 5684 10956 5683 DISINHIBITION OF SNARE FORMATION%REACTOME%REACT_1178.3 Disinhibition of SNARE formation 6814 5579 6810 5582 5578 MITOCHONDRIAL ABC TRANSPORTERS%REACTOME%REACT_111108.1 Mitochondrial ABC transporters 11194 23456 22 10058 VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME%REACT_228024.1 VEGFR2 mediated cell proliferation 801 805 808 7297 8877 3708 5604 3709 5605 7529 3845 5921 3569 4893 101060747 3717 3265 3570 5170 3716 5595 5781 5335 5579 3791 5580 983 3710 5590 5594 5578 5894 RAF MAP KINASE CASCADE%REACTOME%REACT_634.9 RAF MAP kinase cascade 7297 5781 5604 5605 7529 3845 983 3569 4893 3717 3570 3265 5594 3716 5595 5894 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_20603.1 Zinc influx into cells by the SLC39 gene family 7922 57181 23516 27173 29986 55630 25800 283375 29985 64116 INHIBITION OF HOST MRNA PROCESSING AND RNA SILENCING%REACTOME%REACT_6173.4 Inhibition of Host mRNA Processing and RNA Silencing 8106 10898 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_20642.3 CREB phosphorylation through the activation of CaMKII 801 805 808 1385 88 1742 816 817 2902 818 10142 2904 4747 815 2905 2906 2903 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME%REACT_1998.3 Gap-filling DNA repair synthesis and ligation in GG-NER 5111 5982 5981 5427 5983 6119 6118 57804 6117 5426 5425 5424 3978 10714 5985 5984 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME%REACT_2001.5 Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor 3714 4853 4854 4855 6868 102 7314 4851 7316 7311 182 54567 28514 6233 C6 DEAMINATION OF ADENOSINE%REACTOME%REACT_1231.3 C6 deamination of adenosine 104 103 LIPOPROTEIN METABOLISM%REACTOME%REACT_6823.1 Lipoprotein metabolism 3931 336 5034 337 116519 1071 8029 3949 4023 9619 3339 6382 19 345 81693 348 4547 344 4018 51128 335 338 2 3990 213 26119 319 METABOLISM OF VITAMINS AND COFACTORS%REACTOME%REACT_11193.3 Metabolism of vitamins and cofactors 55191 4552 1719 4548 32 4594 31 23475 9446 5743 5646 8029 5645 55229 5644 25974 55312 81034 316 53354 55163 8034 6947 10560 55034 81693 9962 3141 9963 56922 60496 60490 27010 8566 166785 23057 5095 326625 5096 101929880 440387 101928493 6948 6470 1504 51293 349565 80025 64087 4338 27249 4524 54 6573 51248 113278 80347 101928717 2694 5091 4522 119391 113235 27304 65220 80704 79178 200895 6515 6513 93100 5167 55788 8884 80308 5740 1528 79717 4363 1582 2194 1727 10135 686 64802 10243 79646 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_12051.3 Cell surface interactions at the vascular wall 482 483 857 3655 9056 9057 7525 5291 3897 2335 3678 3690 3685 2534 3265 2621 4067 5290 481 4312 5624 5781 5335 338 7056 6520 5777 5175 3932 101060363 5627 11136 3684 5197 6464 5196 23428 5478 51744 7010 57126 8140 9123 23539 90952 2147 6566 6401 58494 3687 682 6404 3689 6693 6402 3845 55423 3676 50848 4893 3675 5296 51206 83700 6654 3683 5295 54210 51378 6403 23759 914 23657 3688 961 960 140885 120425 10461 56301 285 284 2207 9046 1525 2886 2734 4973 965 4099 962 101929889 3635 8832 2888 IGF1R SIGNALING CASCADE%REACTOME%REACT_150210.2 IGF1R signaling cascade 8471 1796 29904 6198 7248 51719 81617 101930123 6794 5565 5564 5563 5562 92335 5604 5571 5605 2549 5291 53358 25759 3569 3667 3570 3265 117145 54106 55437 6009 5290 51422 57521 53632 1978 8660 5781 1977 1975 7249 5289 6194 983 2475 30849 6464 5894 152831 2264 9965 7297 5140 7529 3845 64223 4893 26281 3479 101060747 3480 10818 3717 5296 1981 5170 3716 57761 6654 5295 5595 2247 2246 2249 2255 8823 27006 208 2251 2252 3481 2254 2248 8817 8074 5594 5494 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%REACT_121122.2 Acyl chain remodeling of DAG and TAG 8694 80339 11343 84649 57104 VRNP ASSEMBLY%REACTOME%REACT_9434.2 vRNP Assembly 3843 3320 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME%REACT_2085.2 GTP hydrolysis and joining of the 60S ribosomal subunit 6231 6232 6044 26784 26781 100505503 26780 6043 7311 116936 26778 116938 6228 6229 6227 6235 4736 6230 26771 6234 84546 26809 25873 2197 100124516 3646 8669 94163 26791 26790 6233 8668 101060318 677847 6224 6223 6222 6203 6201 6202 23521 1981 595100 6210 6205 6204 6208 6209 6206 6207 6217 6218 3921 6083 6165 6137 6168 6136 6138 6161 6139 6164 6160 8894 1965 6130 6133 9045 6132 6135 6167 101929876 6134 6169 85388 6143 6144 6141 6142 619567 1964 1968 6147 619568 606500 6146 619565 619499 619562 9669 7458 100302143 100529097 1974 11224 1973 1977 26819 1975 26815 1983 26817 26818 26816 6129 51121 6128 6193 6194 6192 6191 26820 652965 6124 6123 652966 6122 6125 9349 6171 574040 6170 619505 6173 8663 100526842 8661 6176 8662 6175 26811 8666 8667 8665 26814 6189 6188 8664 26795 6187 595097 27335 595099 100996747 100508408 6181 595098 6154 6155 6152 6159 8944 6157 6158 6156 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%REACT_150134.2 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 113612 1543 1579 8529 1559 1545 1544 284541 1557 1558 PROSTANOID LIGAND RECEPTORS%REACTOME%REACT_18425.1 Prostanoid ligand receptors 11251 6915 5733 5734 5729 5732 5739 5731 5737 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118659.3 RORA activates circadian gene expression 5465 6604 8648 96764 6907 2033 5469 6095 8841 406 23054 80205 1387 10891 9575 9611 10498 85441 79718 6720 6256 9572 1374 10499 4862 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_121120.2 Keratan sulfate biosynthesis 23563 10331 11081 5549 176 10402 93010 8702 8704 8703 9331 2331 8534 9334 4969 10678 9435 4060 2683 4958 4166 6482 11041 6483 6487 6484 11046 79369 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME%REACT_407.2 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 995 983 891 7465 1111 CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME%REACT_6933.3 Conjugation of benzoate with glycine 92292 10249 116285 348158 219970 100287413 SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_15425.1 Serotonin Neurotransmitter Release Cycle 6616 8541 6571 8499 9256 8224 22999 8497 10497 6853 6854 5864 6844 8500 6804 6857 10815 DEPURINATION%REACTOME%REACT_626.2 Depurination 4968 4350 4595 CONJUGATION OF CARBOXYLIC ACIDS%REACTOME%REACT_6889.3 Conjugation of carboxylic acids 92292 54988 10249 116285 341392 348158 219970 100287413 123876 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_9515.3 FGFR1c ligand binding and activation 2247 2246 2249 26281 2251 2254 8074 MITOTIC G1-G1 S PHASES%REACTOME%REACT_21267.3 Mitotic G1-G1 S phases 5711 1017 5710 1875 5714 6241 1874 5713 1022 5719 3065 1019 6500 902 5715 5716 5701 7311 5696 5687 1026 5695 5700 1163 5694 55957 5717 5718 5688 132660 5689 1027 8454 5111 8900 6502 7029 5001 4999 5000 7465 4998 4331 5720 4171 7316 5426 10213 4176 5698 983 890 4174 4175 5699 7027 4149 23595 990 5721 993 6233 4609 7298 5519 5518 5515 5516 5928 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 5686 5685 5682 9861 9491 5684 5683 1030 1719 9134 898 5925 1871 1870 26271 55388 8317 10926 29935 7084 9088 891 28227 6119 6118 6117 5520 5422 595 84515 4173 23594 4172 5427 23649 5557 5558 1869 8318 81620 91750 1021 1029 7153 1031 1032 5934 896 1859 894 4605 5933 286826 M G1 TRANSITION%REACTOME%REACT_1725.4 M G1 Transition 5711 1017 5710 51053 5714 5713 5719 23198 5715 5716 5701 7311 5696 5687 5695 5700 5694 5717 5718 1871 5688 1870 5689 55388 8317 10926 29935 5001 4999 5000 6119 4998 6118 6117 4171 5720 7316 5426 10213 4176 5698 4174 4175 5699 23595 143471 990 5721 6233 5422 84515 4173 23594 4172 5427 23649 5557 5558 1869 8318 81620 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 5684 5683 HISTIDINE CATABOLISM%REACTOME%REACT_1249.5 Histidine catabolism 10841 131669 3067 144193 3034 MTOR SIGNALLING%REACTOME%REACT_6838.1 mTOR signalling 29904 6198 7248 51719 81617 101930123 6794 5565 5564 5563 5562 92335 5571 64223 1981 55437 6009 51422 57521 53632 1978 1977 1975 208 7249 6194 2475 5494 RESOLUTION OF D-LOOP STRUCTURES%REACTOME%REACT_2229.3 Resolution of D-loop structures 3978 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_118779.6 Extracellular matrix organization 1308 3655 5339 7040 999 3791 1292 1291 4684 1634 3693 1293 100505984 3696 3371 3694 2200 7412 3695 58494 3687 1605 8516 1311 63827 3681 3682 3383 50848 3676 3675 87 3679 22801 977 83700 3384 3385 5154 3386 3683 8573 3381 3691 6696 3918 3688 3914 960 5340 3909 5045 7057 9510 9508 9509 2243 3818 7448 170692 2 11095 84467 11096 645832 650 56999 2266 140766 2201 2006 2244 5175 3684 1520 1282 1298 4314 1285 375790 1284 1297 1514 1513 1287 3689 1515 1508 131873 1299 1463 1286 256076 9507 4060 23385 1306 57642 10491 1301 7373 85301 64175 1307 5352 5351 26577 169044 23127 136227 55214 100653071 3339 2335 6383 50509 81578 1303 1300 1305 1302 10516 1295 4317 5479 4236 4316 4237 1296 4312 30008 79709 4319 4238 7177 4239 7077 1290 652 3817 655 5650 27302 22795 10893 4313 5155 871 4326 91522 101 1278 4325 8985 4327 1277 8754 8751 10536 5118 4324 340267 4323 4320 1281 4322 1280 4321 1288 633 80781 9313 1991 255631 5663 1289 1310 826 5578 84570 823 100500840 59277 10319 4921 9378 7093 4811 64386 682 176 6382 8200 6385 2202 8425 4052 4054 4053 2199 2192 8076 1756 2247 4015 170690 4016 1511 84171 4017 84695 961 7092 649 3672 1294 3673 51399 7276 780 1509 100616237 5034 6868 8515 4318 5645 5644 3912 3678 3690 3685 3915 3674 284217 3680 4148 4593 1758 4038 63923 3911 440387 102 3910 8785 3913 1504 6678 7148 54829 7143 5802 7043 3908 7042 1834 1404 4146 836 9672 5054 2331 7076 1462 1215 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME%REACT_19277.2 Sema4D induced cell migration and growth-cone collapse 4629 391 3984 4628 5364 3985 4627 388 387 9475 389 6093 998 23365 5880 2064 103910 79784 27289 10398 4637 10507 9826 5879 CA2+ PATHWAY%REACTOME%REACT_172761.2 Ca2+ pathway 7481 1499 27161 5158 6932 8323 2535 6934 8322 5145 4343 59345 94235 5148 26523 5592 83439 3710 7976 2780 2775 23236 51701 5578 801 2785 5593 805 2786 808 51764 2783 2784 2787 5330 2788 2791 57690 5331 3708 3709 815 5534 55970 54331 10681 192669 2793 2792 23112 2790 192670 5530 5532 4772 2782 7855 27327 7474 51176 6885 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_24969.1 TRAF6 mediated NF-kB activation 4214 8517 57506 23586 6288 7186 3146 64135 4615 351 6285 4791 5970 177 84282 4792 4793 1660 4790 7706 1147 6283 7189 3551 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME%REACT_21352.4 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription 3066 728340 8335 8334 1022 653604 3065 8337 8331 902 30834 255626 6621 84265 8358 333932 8352 55718 8359 9013 8353 8354 9014 8338 171568 8339 677805 9533 5451 474382 4331 8357 8356 8347 57459 7019 8348 10302 8345 7270 55703 8346 6908 8340 57504 79101 10849 5442 54700 64216 8343 8344 8341 8342 3021 64425 3020 692063 4782 85236 2968 4784 2967 8968 8360 8362 8361 100302240 84172 8364 54145 8363 8365 8366 4774 8970 27297 8368 8349 8367 100616282 5928 8351 654320 9112 8350 9015 25885 8355 5595 6619 3013 3012 51082 284119 692072 54815 5440 677822 8932 723790 5441 10623 126961 10621 8294 11335 10622 7343 677792 2068 2074 2071 5931 2972 8850 554313 121504 2976 9219 2971 2975 3015 4781 3014 8370 3018 6617 2965 2966 3017 6618 53615 1108 1107 2648 10919 5437 5434 5435 128312 101928686 221830 661 9328 9329 7978 55814 9330 101060521 7702 6741 51728 11128 55290 SIGNALING BY FGFR4 MUTANTS%REACTOME%REACT_121286.2 Signaling by FGFR4 mutants 2264 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_120726.3 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 50855 387 7048 7046 56288 7314 7040 2280 7316 7311 50848 5590 57530 101929368 23370 57154 6233 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME%REACT_228145.1 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 5111 4436 6119 6118 57804 6117 5425 5424 4292 3978 10714 5395 2956 9156 SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME%REACT_2032.3 Synthesis of dolichyl-phosphate mannose 54344 8818 8813 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME%REACT_1385.3 Processive synthesis on the lagging strand 5422 5111 2237 23649 5557 6119 6118 57804 6117 5558 5425 5424 3978 10714 1763 ACROSOME REACTION%REACTOME%REACT_163938.2 Acrosome Reaction 49 CREATINE METABOLISM%REACTOME%REACT_813.4 Creatine metabolism 1158 1159 2628 6539 6538 1152 6535 1160 6534 2593 548596 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_163793.3 Processing and activation of SUMO 7341 10054 6613 6612 205564 10055 101929087 29843 59343 7329 AMINE-DERIVED HORMONES%REACTOME%REACT_15513.1 Amine-derived hormones 1081 438 1734 1644 1733 121278 389434 7173 1735 5409 6528 15 7054 7166 1621 7252 COLLAGEN DEGRADATION%REACTOME%REACT_150401.3 Collagen degradation 1306 6868 7373 4314 1308 1298 1307 1514 1297 4318 1513 5645 5045 136227 1508 1299 1303 1305 4317 4316 4312 4319 102 4313 91522 4327 8754 4324 4323 4320 4322 4321 1509 9313 80781 1991 1310 84570 CD28 CO-STIMULATION%REACTOME%REACT_19183.3 CD28 co-stimulation 253260 9402 940 9020 942 941 5063 5062 7525 5058 64223 101060747 2534 5296 5879 117145 5170 79109 4067 57761 5290 8503 5295 10000 207 7409 208 998 2475 3932 1326 RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME%REACT_228239.1 Release of Hh-Np from the secreting cell 2262 6868 50846 6469 147111 85455 57758 3549 PROPIONYL-COA CATABOLISM%REACTOME%REACT_993.3 Propionyl-CoA catabolism 166785 5095 4594 5096 84693 NICD TRAFFICS TO NUCLEUS%REACTOME%REACT_2155.6 NICD traffics to nucleus 4853 1387 4854 4855 9794 84441 4851 2648 8850 22938 55534 10046 3516 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_160300.3 Binding and Uptake of Ligands by Scavenger Receptors 3040 3043 9332 28442 28916 259 28454 3039 28912 3493 23166 286133 3494 78989 3263 4481 81035 3240 3250 348 8578 10808 8542 8685 117156 948 335 55576 338 6288 3320 28908 28299 6678 10525 213 1278 1277 1281 3538 1282 5648 3539 7184 1284 100423062 4035 100500842 3542 811 3514 2495 28776 28876 28874 2512 28896 28834 440786 TOXICITY OF BOTULINUM TOXIN TYPE F (BONT F)%REACTOME%REACT_200659.2 Toxicity of botulinum toxin type F (BoNT F) 9900 9899 22987 6843 6844 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME%REACT_18348.4 ATF6-alpha activates chaperones 811 7184 51360 4801 22926 1649 3309 8720 4802 100500842 4800 468 P38MAPK EVENTS%REACTOME%REACT_12065.4 p38MAPK events 5600 3845 5603 5900 5898 7867 5899 4893 3265 6300 9261 1432 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME%REACT_1835.3 Transport of Mature mRNA Derived from an Intronless Transcript 100302196 9631 51692 53371 10762 4927 10189 5903 55746 8021 8086 129401 7175 9883 8480 53981 22916 1977 9688 4686 23225 23165 9972 11097 57122 23279 29894 10482 79902 23511 100126351 79023 348995 23636 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_7961.4 Telomere C-strand (Lagging Strand) Synthesis 5422 5111 5982 5981 5427 5983 2237 23649 6119 5557 6118 6117 57804 5558 5426 5425 5424 3978 10714 5985 5984 1763 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME%REACT_9027.5 Toll Like Receptor 10 (TLR10) Cascade 5604 5605 7311 3569 3570 9261 3656 23118 51295 7336 1845 5781 1848 3654 1849 6288 466 1846 2353 7100 10454 100996792 7316 246330 64127 5608 983 7867 6285 4791 5598 177 5599 1660 7334 7335 1147 6283 6233 7189 5606 9252 4214 7297 1385 5601 57161 5602 10392 1386 51135 57162 3146 2002 8767 1432 4615 257397 5519 3725 6416 5518 4205 351 5515 5516 4208 3717 3716 5595 5600 5528 8517 6195 6197 7314 6196 81793 5970 4792 5594 4793 5609 4790 6885 3551 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_12627.3 Generic Transcription Pathway 1875 1874 3065 148156 115509 9534 790969 7753 7752 158399 100527943 80110 80108 126070 221785 654254 9794 55713 23619 199692 125919 29079 80139 2516 6256 6258 6257 4609 6604 126375 440519 4221 7733 7738 7050 55534 7711 7728 4092 80205 113835 3726 101929496 84671 7068 56242 353355 9862 90390 7743 65243 8850 440515 100130863 7745 7067 65251 7748 7767 7768 7766 7770 7769 100131980 55778 7760 171392 7762 7757 2648 30832 7761 7755 285349 100129543 374900 7539 51003 4853 4854 4855 55786 441234 7712 84441 255403 7988 84436 4851 4088 4089 84449 144348 390927 7771 4878 7773 729944 55762 4087 90827 26149 283876 342926 400720 84924 57541 57547 84626 6667 199704 27300 140612 10127 84914 7700 1387 57573 7549 5178 26974 26152 147741 7551 619279 7552 5933 84911 7556 220992 374928 10520 100289635 340385 101928160 57711 367 90874 121274 64750 7004 7005 201514 7003 7029 51058 7710 256051 57335 22938 84246 10308 57336 7027 7025 26048 162972 96764 79759 79755 5916 101929245 5915 5914 388567 388569 388566 79744 5241 339327 442319 51385 148254 388561 148266 148268 58492 58491 59348 146434 388536 79718 219749 57343 57209 2099 90338 10155 79788 158431 60436 7678 142 93134 9477 148213 80818 147837 101929740 339559 80095 100131539 25888 148206 148203 51123 860 79970 23327 79973 387032 112950 162966 9422 90594 10172 90317 646915 80264 3516 92595 79986 10168 7692 7695 80032 9439 7694 7697 90333 7699 9443 9441 9442 9440 54925 57677 163051 163050 730291 349075 55634 54778 728957 286075 92285 92283 65988 11105 23054 7673 7638 7101 84124 730087 169841 163059 440077 285971 284309 10001 100129842 284307 91975 101928852 284306 163049 100131827 7181 348327 163227 81857 7625 7627 57615 7626 10224 51592 81856 169270 7633 170960 55657 126231 163255 1490 342132 136051 80317 147657 79230 115196 9612 9611 353088 10498 353274 7618 7652 55888 162239 163223 55663 7182 51586 10499 7621 79175 219578 6907 9668 155054 79943 155061 3172 199777 389114 147694 55659 126382 728927 170959 3164 54989 6910 285902 147686 147687 9282 90589 90592 162967 162963 100287226 892 9968 9969 339500 90576 9975 101928434 6940 2063 7311 90233 25799 282890 7316 6233 374655 6097 79818 63934 146542 6096 6497 146540 6095 6498 147948 147949 79088 8431 7323 84874 7321 7314 401509 2100 90649 91120 8427 85441 374879 8239 168417 5465 8463 1030 2103 2104 2101 163071 29959 1025 1024 7586 7587 84765 7582 7581 9310 84838 163081 94039 7571 55900 5467 284370 127396 5469 146198 7594 7596 5468 7592 100507342 162655 904 124411 101927758 905 51276 57474 284443 7562 7566 7561 7567 7576 7574 344787 79862 10046 147923 7376 7568 147929 54807 10795 283337 8648 57693 10794 10793 7421 54811 10413 152687 285268 285267 4929 284459 27153 22869 7559 7565 5054 10780 10025 10781 10782 84527 23660 90075 340252 114026 3174 22835 83744 253639 84775 126068 80778 25937 148103 197320 163087 79898 55422 79891 58500 79027 285676 51333 5494 93474 168374 9572 117608 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME%REACT_1050.3 Gamma-carboxylation of protein precursors 8858 5624 2158 2155 2147 2159 5627 2621 2677 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME%REACT_1707.4 CDC6 association with the ORC:origin complex 1869 84515 23594 5001 4999 5000 23595 1871 1870 990 4998 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME%REACT_18347.1 Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity 160 80852 27092 816 5582 817 818 101929306 23426 815 2892 2891 4193 2893 9495 10369 10368 5579 1742 4646 2890 9463 2036 101930324 1739 4905 59283 5578 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME%REACT_6894.9 Toll Like Receptor 4 (TLR4) Cascade 330 148022 7322 329 10010 11035 5604 7187 9641 5605 100302736 7311 4064 1785 3656 26052 23118 51295 7336 1845 1848 3654 1849 5336 7099 466 11213 1846 2353 695 7097 10454 100996792 3665 929 7316 246330 64127 5608 983 7867 3661 353376 6285 29110 4791 7098 5598 177 8651 5599 114609 1660 7334 7335 1147 6283 6233 7189 7297 1385 1432 5519 5518 5515 5516 3717 5595 5600 5528 7323 8517 6195 7321 6197 7314 6196 5970 4792 5594 4793 4790 6885 3551 3569 3570 9261 948 5781 6288 9450 3684 5606 9252 4214 23643 10333 5601 57161 5602 10392 1386 51135 57162 3146 2002 3689 8767 4615 257397 6416 3725 59307 4205 351 4208 3716 1759 8772 8737 841 5609 3929 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%REACT_7980.9 Toll Like Receptor 2 (TLR2) Cascade 5604 5605 7311 3569 3570 9261 3656 23118 51295 7336 1845 5781 948 1848 3654 1849 6288 7099 466 11213 1846 2353 695 7097 10454 100996792 929 7316 246330 64127 5608 7867 983 6285 4791 5598 177 8651 5599 114609 1660 7334 7335 1147 6283 6233 7189 5606 9252 7297 4214 23643 1385 10333 5601 57161 5602 10392 1386 51135 57162 3146 2002 8767 1432 4615 257397 5519 6416 3725 59307 5518 4205 351 5515 5516 4208 3717 3716 5595 5600 5528 8517 6195 6197 7314 6196 5970 5594 4792 4793 5609 4790 6885 3551 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_121153.2 Signaling by activated point mutants of FGFR1 2247 2246 2249 26281 2251 2254 2260 8074 TRKA ACTIVATION BY NGF%REACTOME%REACT_11060.3 TRKA activation by NGF 4914 4803 APOPTOSIS%REACTOME%REACT_578.8 Apoptosis 5711 5710 3009 5714 3007 5713 3008 5719 3024 6093 23198 329 79658 5062 572 5339 5715 3005 5747 5716 3006 5701 7311 5696 5687 4001 5695 5700 5588 5694 999 2339 5717 5718 5688 5689 581 598 596 2934 4836 5720 7316 10213 324 5580 5698 5699 7027 5599 3148 842 143471 10059 1676 5721 1677 6233 7532 118 7431 8655 10197 5707 5706 1630 578 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 6709 122706 5686 5685 5682 9861 9491 5684 5683 6868 331 637 100422899 100422832 90427 7533 3002 54205 840 56616 317 1829 100506658 1832 1830 1828 9414 5317 7082 2620 22985 28988 51765 6304 10134 660 4137 7531 836 8428 693222 3146 7529 7157 90249 1869 9500 5366 219699 5534 26060 1613 23604 1612 7534 8717 10000 63967 207 208 7132 3836 355 7186 8772 8837 356 8737 8795 3837 10018 27113 5533 140735 841 2810 10971 843 8743 7124 839 TRANSLESION SYNTHESIS BY HREV1%REACTOME%REACT_8.3 Translesion synthesis by HREV1 51455 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_150203.2 IRS-related events triggered by IGF1R 8471 1796 29904 6198 7248 51719 81617 101930123 6794 5565 5564 5563 5562 92335 5604 5571 5605 2549 5291 3569 3667 3570 3265 117145 54106 55437 6009 5290 51422 57521 53632 1978 8660 5781 1977 1975 7249 5289 6194 983 2475 30849 5894 152831 2264 9965 7297 5140 7529 3845 64223 4893 26281 3479 101060747 3480 10818 3717 5296 1981 5170 3716 57761 6654 5295 5595 2247 2246 2249 2255 8823 27006 208 2251 2252 3481 2254 2248 8817 8074 5594 5494 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_121401.2 Glycerophospholipid biosynthesis 64900 81490 590 2819 10390 122618 204962 26279 1120 56261 8605 8694 1119 6901 100137049 150763 84649 23646 80339 80736 154141 56894 56895 3032 10400 255189 3030 9489 84803 10554 10555 10423 23175 23171 8681 55326 5321 54675 114971 11343 254531 162466 5337 57678 50640 5338 79143 9926 201164 64600 253558 55500 123745 81579 151056 9468 5833 57153 23761 23760 50487 23446 137964 56994 85465 126969 1040 79887 79888 100652777 55224 11145 54947 129642 1103 30814 9663 283748 5320 5130 5322 5319 8443 8760 10162 43 8398 57104 9791 8399 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_6904.2 Phosphorylation of the APC C 11065 51434 996 7324 891 29882 7321 64682 246184 8697 29945 8881 51529 983 730268 51433 10393 5347 RESPONSE OF MTB TO PHAGOCYTOSIS%REACTOME%REACT_121042.3 Response of Mtb to phagocytosis 4057 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME%REACT_75790.2 Cytokine Signaling in Immune system 6043 1398 55746 3561 3574 3082 6777 8503 3055 7409 23586 9846 4684 7706 677847 7006 816 817 7412 818 815 3383 9883 7175 1981 5595 8517 5495 1154 23225 960 3572 3839 3838 2210 9021 3459 3841 3460 3840 1982 2209 2317 25820 5970 373856 2889 9470 1399 8672 4790 402569 8554 3458 3606 317649 6885 8835 3551 3568 3558 3567 1438 3559 7324 3560 1439 51191 5291 5293 567 3569 3667 2534 3562 3570 3563 1437 7318 5290 6772 6774 5781 1974 1973 1977 100847079 834 5777 23165 5300 23279 79902 6464 9246 9636 7529 6416 7534 129401 3442 3440 3441 4734 3439 3451 3443 3444 9688 3452 3448 3449 3445 3446 3660 9972 3659 3456 115361 3115 6672 100509457 3117 3119 3118 8945 10437 388646 4261 26781 4502 163351 5604 6500 100507709 2633 5605 3113 2635 115362 7311 3122 7525 5696 6850 3265 100996809 100507714 101060835 3120 4067 3123 8454 3656 23118 7336 8660 5335 3654 11213 3133 10454 3665 7850 3554 246330 7316 4215 64127 3557 5580 5608 3661 983 54472 3125 3553 3107 9978 4791 3126 3106 8878 3127 3932 8651 7334 3552 1147 7335 1326 6233 5894 7189 79155 7297 29760 3845 4893 8021 3717 4599 3105 6773 3433 3434 100132417 8638 10581 3437 1443 1444 3135 10379 3394 4938 2690 4939 4600 2689 3662 2688 8519 1958 867 54739 3454 7314 2185 3134 6041 11274 4940 10410 51447 3430 3429 2634 2537 5770 11097 3663 3669 3664 5594 23511 5618 1442 23636 6868 10762 619567 619568 5903 100302143 7341 8480 5724 5568 5567 5566 348995 652965 652966 9631 57161 10392 53371 51135 103 57162 8767 4927 4615 257397 5610 8086 5617 5296 3575 3716 6776 6654 3718 5295 3836 3837 57122 5371 9775 3635 3636 79023 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME%REACT_20646.1 Sodium-coupled sulphate, di- and tri-carboxylate transporters 9058 26266 6561 64849 284111 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_111176.1 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 801 5593 805 808 1719 4846 207 3320 6697 5805 2643 2644 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_25351.4 TRAF6 mediated induction of TAK1 complex 23118 23643 148022 7099 7314 10454 100302736 257397 929 7316 7311 353376 7098 6885 6233 7189 MPS II - HUNTER SYNDROME%REACTOME%REACT_147734.2 MPS II - Hunter syndrome 23563 10331 2239 3373 79586 9469 3339 126792 9653 3073 3340 3074 6383 11285 10678 9435 3038 9394 10675 3037 3036 2720 283464 8372 100616124 2719 727936 4958 9957 11041 9956 9955 633 3425 1634 3423 11046 79369 27087 9348 347734 11081 411 176 63827 6382 643853 6385 8509 8702 26035 8704 8703 9331 10855 9334 4969 10861 2262 10057 29940 2990 64579 2817 2132 2131 60495 960 55454 10082 6482 6483 6487 6484 1836 6548 135152 56548 266722 10402 51363 22856 221914 222537 93010 10090 10894 55576 2799 6448 8692 337876 26229 90161 64711 166012 11261 375790 3161 113189 5549 9951 9953 9672 1463 4669 2331 51000 8534 50515 4060 1464 9060 1462 55790 2683 92126 55501 4166 9061 79411 54480 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_12380.1 VEGF ligand-receptor interactions 7422 3791 7423 2277 5228 2321 2324 7424 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_115852.2 Signaling by constitutively active EGFR 5335 3320 11140 867 7314 2549 3845 7316 1950 7311 4893 3265 6464 5290 6654 1956 5295 6233 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%REACT_12596.2 Translocation of ZAP-70 to Immunological synapse 3115 100509457 3117 28577 3119 3118 916 915 100507709 3113 3122 920 917 100996809 100507714 101060835 3120 3123 28639 7535 28755 3125 3126 3127 3932 PI3K AKT ACTIVATION%REACTOME%REACT_12464.5 PI3K AKT activation 6199 3815 2932 23035 572 4803 2064 2549 1950 5291 5293 1026 27161 3667 2534 5728 117145 145957 79109 2931 5290 1027 4343 8503 1956 2309 5156 8660 5781 7409 2069 26523 5155 7249 3164 2475 1839 3932 23239 842 1147 50852 152831 253260 2264 9965 1385 387 940 3084 685 57690 942 941 84335 64223 26281 101060747 10818 5296 4193 9542 192669 930 5170 5159 23112 57761 10718 5295 10000 2247 2246 192670 2249 2255 8823 207 27006 208 2251 2252 2254 2308 2248 8817 8074 27327 4914 FRS2-MEDIATED CASCADE%REACTOME%REACT_21247.3 FRS2-mediated cascade 152831 2264 9965 7297 5604 5605 7529 3845 3569 4893 26281 10818 3717 3265 3570 3716 6654 10817 5595 2247 2246 2249 2255 5781 8823 27006 2251 2252 2254 2248 8817 8074 983 5594 5894 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME%REACT_15518.5 Transmembrane transport of small molecules 54822 80036 80727 1179 1180 1181 54795 94015 63982 121601 101929373 10110 266675 9629 144453 51393 59341 40 7809 22802 1193 162514 29850 55746 41 1184 1183 285335 1182 1188 1187 1186 1185 11059 55283 55503 6263 6262 56302 6261 285175 6446 55515 7439 55129 100533105 7442 79054 150159 65266 26133 65267 65268 55107 219931 9635 196527 7223 7224 1831 7226 65125 140803 51802 284525 255231 10786 537 203859 338440 9311 8989 23678 6527 6340 6339 6338 6337 54831 9883 50636 259232 57192 57719 28962 57101 79901 28982 23169 527 528 526 525 523 9114 529 9296 51382 50617 23545 10312 245973 8992 245972 80736 127124 101927180 533 534 535 90423 51606 155066 6556 9550 23165 11194 10349 21 5825 10347 64137 23460 6581 23456 6582 10351 101930322 89845 1080 57153 8504 10058 6580 225 10060 368 129401 10257 26154 5824 20 85320 1244 6521 55676 126969 148867 169026 6539 6005 6538 6534 10350 340273 6528 64241 64240 64924 482 483 486 2743 2741 57205 2742 2646 3163 3162 5348 441509 170572 92579 374868 51761 79895 540 479 477 478 476 9914 23120 285242 481 480 100616124 11046 5894 347734 101927137 7220 100533181 10861 10396 27032 53828 5205 3359 3101 57198 57194 5349 496 495 10079 9177 148229 200909 23200 9429 11097 8001 23250 53822 53826 23511 286410 7922 6548 6583 81031 83697 55315 153201 6578 84912 6550 117247 2542 29985 23315 204962 9152 6553 9056 9057 9154 9153 9058 5172 29988 29986 9356 5903 6549 6560 101930184 6561 376497 6564 6563 284111 6565 23443 389015 11182 6505 6506 55089 57835 121260 6517 6509 6512 283375 6522 6520 6575 57818 11254 6519 84102 123041 6570 6574 6571 6523 54407 81539 6526 8170 6524 114134 6568 25800 6569 9376 11136 6584 57419 23428 116085 6530 23327 91749 9843 1356 9631 6533 51458 340024 8140 6541 80024 146802 6529 26503 115111 246213 2030 154091 285195 3177 6540 6536 101930602 6511 6508 6507 142680 57127 353189 6510 24 140679 9187 1468 3099 3098 2538 1317 10999 57468 11309 51764 160728 7779 7781 6547 27173 10864 7780 2791 57084 254428 28965 55244 55356 53919 10568 92745 6559 57181 55343 85413 6543 261729 10559 55240 222962 55630 57113 5002 57030 2778 23446 7175 8671 10681 26266 54716 283652 64116 6557 6558 206358 6515 84679 6513 115019 490 10057 4891 491 23516 10991 492 23657 8884 493 7355 55117 84889 9197 64078 4363 10479 1811 7225 10723 7222 23225 55867 124935 9990 56301 28231 348932 51296 25769 30061 9497 8501 115584 60482 64849 1836 65010 57282 9498 200010 59345 487 10599 213 345274 28234 6546 8714 23279 489 79902 488 6579 2785 2786 22 2783 2784 2787 2788 2560 2561 2562 2569 2567 2566 200959 2557 2554 2556 55970 2559 107 2558 108 2495 54331 2793 109 2792 2790 51000 2512 7037 2782 9688 2555 55879 9972 57578 10345 4308 53373 9619 133308 100509620 7311 282679 362 112 115 114 94235 111 113 23229 196883 2570 7316 6233 215 9194 5243 9123 23539 6566 8021 7314 56606 6531 6518 66035 155184 23636 10762 8480 335 8766 360 5577 361 5576 5573 5568 5567 5566 22841 51248 551 554 4645 358 5575 113235 359 348995 53371 4927 8086 363 4284 364 366 7018 101930168 6833 89872 6514 343 2645 538 57122 79023 ZINC TRANSPORTERS%REACTOME%REACT_20530.1 Zinc transporters 55676 7922 148867 7779 7781 23516 27173 169026 7780 283375 29985 57181 29986 55630 25800 64116 64924 HYALURONAN METABOLISM%REACTOME%REACT_121083.2 Hyaluronan metabolism 6548 10894 3038 10057 11261 2990 3037 55576 3036 3373 3161 8372 960 3073 8692 3074 ERK MAPK TARGETS%REACTOME%REACT_12599.1 ERK MAPK targets 5600 9252 5528 1845 1848 6195 1849 6197 1846 2002 6196 1432 5519 4205 5518 5515 4208 5516 5598 5594 5595 INTRINSIC PATHWAY%REACTOME%REACT_326.1 Intrinsic Pathway 5547 3818 2161 2 2812 2811 2160 7450 710 2147 2815 2814 3827 708 2158 2159 2157 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME%REACT_21399.2 activated TAK1 mediates p38 MAPK activation 3656 5600 5606 23118 8517 3654 10392 10454 8767 100996792 1432 257397 64127 5608 7867 9261 6885 7189 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_1213.5 Apoptosis induced DNA fragmentation 3009 3007 3008 3024 836 3836 3146 3005 3006 3837 3148 1676 1677 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME%REACT_125.3 Processing of Capped Intron-Containing Pre-mRNA 26787 6428 6429 2521 4904 5438 6430 5439 6625 5436 10250 9128 6629 6628 6627 6432 6626 6431 10262 55749 55746 11100 6634 6633 6635 6636 53981 10992 6637 10421 7307 8683 9785 24148 1660 100126351 100302196 51692 8021 10594 101929240 7175 9883 55110 8106 22916 10236 2962 5440 2963 5441 23020 23225 11097 51362 83443 6632 6427 6426 5356 23511 51585 8243 23636 9939 85390 22826 5093 10762 4670 51639 988 5725 5437 5094 5434 57794 5903 85389 5435 3178 8480 4116 84844 100529097 1977 7884 11338 56339 79869 1477 23165 101928747 1478 23279 10978 10482 79902 348995 1479 27316 9343 10949 9631 10946 693221 4809 53371 10181 9410 10291 3192 3191 4927 57819 10189 8086 3312 8175 129401 5431 9416 5433 5430 11051 5432 10921 51503 27339 3187 9295 3188 220988 3184 3183 3185 9688 283459 10907 10286 3181 4686 56259 3190 10914 9972 23450 23451 57122 29894 79023 65109 100616459 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_150425.2 Resolution of Sister Chromatid Cohesion 6232 9133 23047 55746 5885 9126 2491 57082 23244 983 5905 5519 5518 5515 5516 10726 5347 5529 5528 5527 5525 23122 5526 23332 8243 57405 1058 80152 83540 9184 991 699 1062 1063 1060 151648 9183 348235 81565 25909 55166 3796 57551 5903 8379 79019 55920 11130 100527963 5048 22919 23421 55143 55839 91687 64105 891 81930 79172 6249 9212 80776 4085 84643 3619 9793 25936 401541 11243 100526739 147841 23279 151246 79902 220134 6396 701 378708 348995 23063 113130 55055 54821 54820 11004 9735 79980 79003 10735 79682 5501 64946 54908 10274 10403 332 57122 79023 7514 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%REACT_13695.1 p75NTR negatively regulates cell cycle via SC1 3066 4804 3065 11108 8841 4803 FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME%REACT_6737.3 Formation of the active cofactor, UDP-glucuronate 7360 23169 7358 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_118707.4 Regulation of Complement cascade 731 730 10878 733 732 721 629 1378 720 727 729 4179 722 3426 725 718 717 7448 1604 966 645832 100293534 3075 5627 735 KERATAN SULFATE DEGRADATION%REACTOME%REACT_121313.2 Keratan sulfate degradation 4969 4060 11081 2720 5549 2799 176 643853 4958 3073 3074 79411 2331 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_200759.2 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 6997 5460 2247 6774 2041 27022 6657 79923 7547 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_15418.1 Norepinephrine Neurotransmitter Release Cycle 6616 6582 8541 6571 8499 9256 4128 22999 6580 8497 10497 5864 6844 6804 6857 8500 10815 HDMS DEMETHYLATE HISTONES%REACTOME%REACT_228178.1 HDMs demethylate histones 22992 55818 653604 221656 23081 8968 8284 8360 9682 8362 8361 55693 8364 8363 8365 8366 8368 8367 8351 8350 8355 8358 333932 23028 8352 8359 8353 8354 23135 84678 23133 126961 8294 8357 5253 8356 8242 80853 51780 23030 554313 121504 5927 10765 8370 84159 7403 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%REACT_8006.8 Toll Like Receptor TLR6:TLR2 Cascade 5604 5605 7311 3569 3570 9261 3656 23118 51295 7336 1845 5781 948 1848 3654 1849 6288 7099 466 11213 1846 2353 695 7097 10454 100996792 929 7316 246330 64127 5608 7867 983 6285 4791 5598 177 8651 5599 114609 1660 7334 7335 1147 6283 6233 7189 5606 9252 7297 4214 23643 1385 10333 5601 57161 5602 10392 1386 51135 57162 3146 2002 8767 1432 4615 257397 5519 6416 3725 59307 5518 4205 351 5515 5516 4208 3717 3716 5595 5600 5528 8517 6195 6197 7314 6196 5970 5594 4792 4793 5609 4790 6885 3551 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_118595.4 Mitochondrial protein import 100652748 56993 8604 498 131474 131118 29090 3329 3313 2395 9804 27235 401505 29928 10063 10651 1537 617 653252 10245 10440 10452 2671 10469 6901 80273 9512 23203 10165 92609 134266 1678 9868 291 293 50 3421 1431 516 54543 100287932 25813 506 26517 51025 7416 150274 4580 26520 100188893 197257 26515 26519 26521 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_150420.2 Synthesis of Leukotrienes (LT) and Eoxins (EX) 91227 2678 1580 57834 1579 240 9261 241 64180 64174 246 126410 8529 4363 284541 92086 4051 4048 101928830 1800 22949 11283 2687 728441 4056 ACTIVATION OF PUMA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_121.4 Activation of PUMA and translocation to mitochondria 7157 27113 1869 7027 100422899 100422832 METAL ION SLC TRANSPORTERS%REACTOME%REACT_20547.1 Metal ion SLC transporters 7922 7779 9843 7781 1356 27173 7780 254428 29985 57181 29986 55630 1317 64116 55676 148867 4891 23516 169026 283375 6556 84102 30061 25800 64924 NEPHRIN INTERACTIONS%REACTOME%REACT_23832.2 Nephrin interactions 81 88 9863 8826 8440 89 8976 4690 6709 5291 87 2534 5296 6711 23607 5290 84063 84623 5295 8573 PYRIMIDINE CATABOLISM%REACTOME%REACT_1023.3 Pyrimidine catabolism 4907 64902 1890 151531 84618 56953 1806 51733 30833 1807 7378 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_75768.2 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 6231 6232 6044 26784 100505503 26780 7311 116936 26778 116938 6228 6229 6227 6235 4736 6230 26771 6234 84546 5976 26809 25873 2197 100124516 94163 26791 26790 6233 6224 6223 6222 6203 6201 6202 23521 1981 595100 6210 22916 6205 6204 6208 6209 6206 6207 6217 6218 3921 6083 6165 6137 6168 6136 6138 6161 6164 2107 6139 6160 6130 6133 9045 6132 6135 6167 101929876 6134 6169 85388 6143 6144 6141 6142 6147 606500 6146 619565 619499 619562 11224 100529097 26819 26815 26817 26818 26816 6129 51121 6128 6193 6194 6192 6191 26820 6124 6123 6122 6125 9349 6171 574040 6170 6173 619505 100526842 6176 6175 26811 26814 6189 6188 26795 6187 595097 595099 100996747 4686 100508408 6181 595098 23708 6154 6155 26986 6152 6159 8944 6157 6158 6156 G2 M DNA REPLICATION CHECKPOINT%REACTOME%REACT_1846.2 G2 M DNA replication checkpoint 9133 983 9088 891 7465 NICOTINAMIDE SALVAGING%REACTOME%REACT_11213.1 Nicotinamide salvaging 93100 5740 5743 1582 10135 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_24968.6 Retinoid metabolism and transport 336 337 2239 4036 375790 26020 4035 4023 3949 83875 3339 9672 6382 51109 151056 221914 6385 5948 5947 6383 345 5950 348 8644 1109 1208 344 2262 9227 335 338 2817 2719 57016 10082 5406 1645 29967 101927965 7276 7804 53630 INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS%REACTOME%REACT_6916.4 Interactions of Rev with host cellular proteins 9631 53371 5902 10762 4927 5905 5903 55746 8021 8086 129401 7175 9883 8480 4869 5901 9688 23225 3837 23165 9972 11097 1104 57122 23279 79902 23511 79023 348995 7514 23636 RNA POLYMERASE III TRANSCRIPTION%REACTOME%REACT_1371.3 RNA Polymerase III Transcription 4782 4784 55814 6621 4774 9330 27297 5437 84265 5434 5435 101928686 101060521 661 7702 6619 55718 51082 9328 9329 5440 171568 5441 5451 10623 9533 6741 10621 51728 10622 11128 10302 55703 55290 2972 2976 6908 2971 2975 4781 6617 6618 GALACTOSE CATABOLISM%REACTOME%REACT_532.3 Galactose catabolism 2584 5236 2582 2592 55276 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME%REACT_4.1 Ubiquitin-dependent degradation of Cyclin D1 5711 5710 5714 5713 5719 1019 23198 5715 5716 5701 7311 5696 5687 5695 5700 5694 5717 5718 5688 5689 5720 7316 10213 5698 5699 143471 5721 6233 595 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 5684 5683 MITOTIC M-M G1 PHASES%REACTOME%REACT_21300.5 Mitotic M-M G1 phases 91754 9133 6232 1017 5861 8335 5862 8334 653604 8337 10783 2801 79648 81876 10592 2029 8331 10776 8615 255626 10051 4001 23047 5885 55746 9126 8358 333932 8352 8359 8353 8354 8338 8339 5001 4999 5000 474382 4998 8357 23244 8356 4171 55844 8347 5426 64689 8348 29781 4176 54892 8345 26003 23310 8346 4174 387893 4175 8548 8340 23595 8343 990 8344 8341 84930 8342 140609 3021 3020 85236 8968 8360 8362 8361 8364 54145 8363 8365 8366 5519 8970 8368 5518 8349 8367 5515 100616282 5516 10112 8351 23383 7175 9883 8350 10726 25836 9493 8355 5347 5529 3013 5528 3012 5527 5579 5525 723790 23122 126961 8294 5526 23332 23225 554313 121504 3015 3014 8370 3018 3017 57405 996 51053 1058 80152 83540 7324 9184 991 699 23592 1062 5925 1063 1060 151648 9183 9232 348235 81565 25909 55166 3796 730268 57551 8379 128312 51433 79019 55920 11130 1871 100527963 1870 5048 22919 23421 11065 55143 55839 91687 23141 64105 81930 79172 29882 6249 9212 7443 8697 80776 29945 4085 84643 3619 9793 23165 51529 25936 401541 11243 100526739 147841 9700 23279 5520 151246 220134 79902 6396 701 10393 378708 5422 84515 4173 23594 4172 5427 255919 23649 23063 23399 5557 113130 5558 8318 81620 129401 51434 55055 54821 54820 11004 9735 6418 79980 221496 79003 2010 64682 9688 10735 5501 79682 64946 54908 9663 10274 10403 332 8881 8290 9972 7514 5711 5710 5714 5713 5719 23198 5715 5716 5701 7311 5696 5687 5695 5700 5694 5717 5718 5688 5689 2491 57082 246184 5720 7316 10213 5698 983 5699 143471 5721 6233 5578 5905 8021 10197 5707 5706 5709 5708 5690 5705 5691 7321 5704 7314 5692 5693 5702 122706 11097 5686 5685 5594 5682 9861 9491 23511 5684 8243 8815 5683 23636 64900 10762 5903 26271 8480 55388 8317 10926 29935 891 6119 6118 6117 23175 348995 9631 53371 4927 1869 8086 1459 1457 64151 23397 1460 57122 9918 79023 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%REACT_197.4 Branched-chain amino acid catabolism 26275 4329 27034 593 3712 1738 11112 3028 64087 586 549 36 587 38 1629 56922 594 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_118656.3 Activation of NF-kappaB in B cells 5711 5710 5714 5713 5719 8945 23198 6500 5715 5716 5701 7311 5696 5687 5695 5700 5694 5717 5718 5688 5689 8454 5720 7316 10213 5698 5699 143471 1147 5721 6233 8915 84433 10197 8517 5707 5706 5579 23291 5709 5966 5708 5690 5705 5691 5704 7314 5692 5693 5702 10892 122706 5686 5970 5685 4794 5682 4792 9861 4793 9491 4790 5684 6885 3551 5683 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME%REACT_22279.2 Fatty acid, triacylglycerol, and ketone body metabolism 9524 2819 3158 5565 54600 2712 5563 6721 2710 100302263 3157 100996782 2274 29841 1581 1543 1579 4899 219541 150763 23054 51422 79071 4199 11010 7004 7005 7003 3033 3032 3030 284541 9575 10001 2222 788 1666 55326 29079 84246 253017 60481 123 1632 6256 23305 6604 101928625 3155 96764 79993 7296 81857 183 2820 51144 5244 6095 8800 8841 406 57761 80205 1490 9412 6785 400569 10891 9862 90390 9612 2194 9611 10498 85441 79718 1374 51586 10499 5465 8463 64900 336 2101 51703 32 4594 31 6907 1024 27063 5467 8694 5469 55588 1381 1382 1375 5468 1376 27242 376497 84649 51003 47 9477 166785 5095 26230 6576 948 51129 335 5096 56894 56895 84803 10554 10555 3293 211 23179 23175 23171 9971 23097 254531 622 116519 57678 8648 23389 4801 9282 10413 4802 253558 112950 5019 2033 54797 4800 19 54898 6667 64834 84693 50486 892 10025 9968 137964 133522 9969 1892 1387 6837 79888 55090 2168 9439 9663 25937 9443 9441 35 9442 2182 33 8202 2181 34 3992 37 83401 2180 38 6822 9440 25942 9572 4862 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_13696.1 NF-kB is activated and signals survival 4804 3654 7314 4803 7316 7311 8878 5970 4792 4790 3551 6233 7189 VIRAL MESSENGER RNA SYNTHESIS%REACTOME%REACT_6354.3 Viral Messenger RNA Synthesis 2962 5438 2963 5440 5439 5436 5441 5437 5434 5435 5431 5433 5430 5432 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_118798.2 Pre-NOTCH Processing in Golgi 4853 10959 5986 4854 6400 4855 4242 487 5870 5045 3955 10402 150786 4851 2683 6487 6484 489 488 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_18407.5 G alpha (12 13) signalling events 391 393 9475 6093 10276 2768 7410 89846 5879 23263 5290 7074 8503 7204 8997 10672 1894 6915 26230 11214 29 8874 59345 57449 7409 10451 94235 64857 25791 23229 146 147 148 9138 100505585 2245 2785 2786 51764 2783 221472 5364 388 387 9459 2784 27237 2787 389 2788 2791 23365 6453 5880 55970 5924 5296 54331 10681 2793 4168 2792 6654 2790 5295 2782 9181 998 121512 9828 101930241 50649 6655 84033 9826 23370 50650 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_25354.3 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation 246330 7336 8517 3654 57161 57162 7334 7335 1147 3551 7189 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_25325.2 AUF1 (hnRNP D0) destabilizes mRNA 5711 5710 5714 5713 85390 5719 23198 5715 5716 5701 7311 5696 5687 5695 5700 85389 5694 5717 5718 5688 5689 5720 7316 10213 5698 5699 143471 5721 6233 3312 1981 3315 3303 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 122706 5686 26986 5685 5682 9861 3304 9491 5684 5683 PYRUVATE METABOLISM%REACTOME%REACT_2071.5 Pyruvate metabolism 5162 3939 5163 5160 5166 5164 54704 5165 3945 9123 23539 1737 6566 51660 1738 682 5467 55066 57546 1381 1382 6256 25874 8050 MRNA SPLICING%REACTOME%REACT_1735.3 mRNA Splicing 26787 6428 6429 2521 4904 5438 6430 5439 6625 5436 10250 9128 6629 6628 6627 6432 6626 6431 10262 55749 11100 6634 6633 6635 6636 53981 10992 6637 10421 7307 8683 9785 24148 1660 100126351 100302196 51692 10594 101929240 55110 8106 22916 10236 2962 2963 5440 5441 23020 51362 83443 6632 6427 6426 5356 51585 8243 9939 85390 22826 5093 4670 51639 988 5725 5437 5094 5434 57794 85389 5435 3178 4116 84844 100529097 11338 1477 79869 101928747 1478 10978 1479 27316 9343 10949 10946 693221 4809 10181 9410 10291 3192 3191 57819 10189 3312 8175 5431 9416 5433 5430 11051 5432 10921 51503 27339 3187 9295 220988 3188 3184 3183 3185 283459 10907 10286 4686 3181 56259 3190 10914 23450 23451 29894 100616459 65109 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_169311.2 Loss of Function of TGFBR1 in Cancer 1030 1875 1874 3065 1025 1024 7048 56288 7046 60436 5045 7040 54778 9040 56937 7311 100527943 11171 142 904 51377 57154 23645 905 64750 7029 2280 4088 7316 4089 9110 9958 5590 7027 57530 5499 6233 4087 25805 23327 4609 50855 387 4221 10273 7050 6667 51592 6497 50848 5054 6498 892 4092 7323 3726 7321 5500 867 5501 7314 9612 9611 25937 8239 5933 4738 101929368 23370 5494 7514 RNA POLYMERASE I PROMOTER OPENING%REACTOME%REACT_2232.2 RNA Polymerase I Promoter Opening 8335 8334 653604 8337 8331 255626 128312 8358 333932 8352 8359 8353 8354 8338 8339 474382 8357 8356 8347 8348 8345 8346 8340 8343 8344 8341 8342 3021 3020 85236 8968 8360 8362 8361 8364 54145 8363 8365 8366 8970 8368 8349 8367 100616282 8351 8350 8355 5595 3013 3012 8932 723790 126961 8294 7343 554313 121504 3015 3014 8370 3018 3017 BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME%REACT_2025.4 Beta oxidation of palmitoyl-CoA to myristoyl-CoA 37 3032 3030 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME%REACT_1906.3 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 8858 5624 2158 2155 2147 2159 5627 2621 UREA CYCLE%REACTOME%REACT_847.3 Urea cycle 10166 162417 1373 435 384 383 445 83884 5009 HIV TRANSCRIPTION ELONGATION%REACTOME%REACT_6274.4 HIV Transcription Elongation 728340 1022 2968 2967 1025 5438 100126332 5439 5436 902 5437 5434 5435 8178 5431 5433 904 5430 5432 22916 2962 6749 2963 7469 5440 6829 100302242 25920 5441 11198 4331 4686 6827 7936 2068 9150 2071 6921 6924 6917 6923 2965 51497 2966 UPTAKE AND FUNCTION OF ANTHRAX TOXINS%REACTOME%REACT_228255.1 Uptake and function of anthrax toxins 801 805 6416 808 10015 5609 5604 5045 5605 NEF AND SIGNAL TRANSDUCTION%REACTOME%REACT_11068.2 Nef and signal transduction 3055 2534 1794 3932 5879 5062 9844 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_9405.3 Cholesterol biosynthesis 3930 4047 6713 10682 4598 7108 2222 3157 9453 2224 6307 6309 3422 4597 50814 1595 51478 1717 1718 91734 10654 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_22303.1 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors 55584 1135 1134 1143 1136 1141 1137 1142 1139 89832 1138 8973 ACTIVATION OF C3 AND C5%REACTOME%REACT_7972.3 Activation of C3 and C5 721 629 100293534 720 727 718 717 IRS-MEDIATED SIGNALLING%REACTOME%REACT_332.4 IRS-mediated signalling 1796 29904 6198 7248 51719 81617 101930123 6794 5565 5564 5563 5562 92335 5604 5571 5605 2549 5291 3569 3667 3570 3265 117145 54106 55437 6009 5290 51422 57521 53632 1978 8660 5781 1977 1975 7249 5289 6194 983 2475 30849 5894 152831 2264 7297 9965 5140 7529 3845 64223 4893 26281 101060747 10818 3717 5296 1981 5170 3716 57761 6654 5295 5595 2247 2246 2249 2255 8823 27006 208 2251 2252 2254 2248 8817 8074 5594 5494 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_160205.3 NOTCH2 Activation and Transmission of Signal to the Nucleus 3714 4853 55851 9148 54492 102 7314 5664 142678 7311 7316 83464 182 51107 4192 54567 28514 1272 23385 57534 6233 COLLAGEN FORMATION%REACTOME%REACT_120729.4 Collagen formation 1306 57642 5034 10491 1301 1308 7373 85301 64175 3655 1307 5352 5351 26577 169044 4318 5339 23127 136227 55214 100653071 50509 81578 1303 1300 9508 1305 9509 1302 1295 5479 4316 1296 79709 1290 871 91522 1292 1278 8985 140766 1277 10536 5118 340267 1291 1281 1280 4322 1288 80781 9313 255631 1289 1310 1293 84570 1520 1282 1298 4314 1285 1284 7093 1297 1514 1287 1515 1508 131873 1299 977 1286 256076 3691 3918 4015 4016 3914 84171 4017 84695 7092 3909 649 1294 FATTY ACIDS%REACTOME%REACT_13814.2 Fatty acids 66002 1572 126410 101929829 8529 284541 1548 4051 57834 1580 1549 1573 1579 1565 11283 1555 1553 DAG AND IP3 SIGNALING%REACTOME%REACT_111064.2 DAG and IP3 signaling 801 156 805 808 1385 5581 5582 3708 3709 107 108 109 5153 112 5335 115 114 111 5577 5137 113 196883 814 5576 5136 5573 5568 5580 5567 5566 3710 5575 5578 ORGANIC ANION TRANSPORTERS%REACTOME%REACT_19372.1 Organic anion transporters 6528 246213 160728 57030 57084 6568 26503 1468 SYNTHESIS OF PS%REACTOME%REACT_120823.2 Synthesis of PS 81490 9791 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_163710.2 WNT ligand biogenesis and trafficking 101929777 7480 7481 51699 7482 7483 7484 8724 51384 50999 64840 79971 7471 7476 81029 7473 7474 9559 7477 7478 89780 7479 7472 54361 55737 80326 7475 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME%REACT_1988.3 AMPK inhibits chREBP transcriptional activation activity 51085 6794 5565 5563 51422 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_12555.2 Downstream TCR signaling 3115 100509457 3117 28577 3119 3118 916 915 100507709 3113 3122 5291 920 5588 5728 917 100996809 100507714 101060835 3120 5290 3123 28639 23118 7336 28755 3125 3126 3127 3932 7334 1147 7335 50852 7189 8767 101060747 5296 5170 5295 8915 84433 8517 10892 5970 4792 4790 3635 6885 3551 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME%REACT_19266.1 Sema4D mediated inhibition of cell attachment and migration 2909 6237 4233 5364 27289 387 10507 5879 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_120918.2 Synthesis of PIPs at the late endosome membrane 9110 5289 8898 5286 9108 30849 55697 4534 200576 9896 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME%REACT_13.4 Amino acid and derivative metabolism 5711 1081 5710 5714 5713 2729 191 5719 1491 23198 83884 6723 5715 5716 5701 6611 5696 54498 5687 5695 5700 875 883 5694 5717 3081 5718 635 5688 548596 3067 5689 2730 4946 4329 4942 10841 1644 4947 5409 2875 3028 3034 5720 10213 3620 5698 445 440 5699 4953 51582 2593 2806 143471 2805 130013 5721 10157 435 125061 2746 438 55256 189 51380 58472 1610 162417 7263 58478 1629 2744 2752 27430 6999 1621 1728 8424 10197 5707 5706 131669 5709 5708 5690 5705 5691 121278 5704 2639 5692 101929036 5693 5702 10166 4967 1373 2628 122706 51074 5686 5685 5682 55217 9861 9491 27165 5684 5683 1158 23498 1159 4552 26275 64902 4548 593 1160 51166 8659 6303 26227 384 383 84245 1152 8564 56922 594 5723 27034 2954 5009 6470 4143 11112 79814 5053 4144 23474 64087 7054 113451 223 196743 7252 6898 55748 51686 3712 3242 5831 4507 7173 144193 89874 549 15 5625 54363 1743 56267 169355 1036 1734 8942 501 6539 1733 6538 6535 1738 6534 389434 1735 262 29968 1468 6528 586 5092 36 5860 587 2184 38 6821 9380 7166 G0 AND EARLY G1%REACTOME%REACT_111214.1 G0 and Early G1 1017 1875 1874 3065 9134 898 1869 5928 91750 55957 132660 5111 8900 7153 7029 5934 1859 983 4605 890 5933 7027 286826 990 993 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_63.2 RNA Polymerase III Transcription Termination 4782 4784 4774 27297 84265 5437 5434 5435 101928686 101060521 661 51082 55718 5440 171568 5441 9533 10623 51728 10621 6741 10622 11128 55703 4781 LIGAND-GATED ION CHANNEL TRANSPORT%REACTOME%REACT_25387.2 Ligand-gated ion channel transport 2743 2741 2742 2560 2561 2562 2569 2567 2566 200959 2557 441509 2554 2556 170572 2559 2558 285242 3359 9177 2555 23229 200909 55879 2570 8001 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME%REACT_387.3 Cleavage of Growing Transcript in the Termination Region 100302196 6428 6429 9939 84967 693221 6430 51692 10250 6628 6432 6431 10189 6634 6635 11051 6636 55110 53981 8106 22916 4116 6637 10921 9295 134353 7884 11338 7307 283459 8683 4686 9785 10914 1477 79869 25888 51362 1478 6427 29894 6426 10978 51585 100126351 65109 1479 SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME%REACT_150253.2 Synthesis of IPs in the ER lumen 9562 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_169435.2 Loss of Function of TGFBR2 in Cancer 1030 1875 1874 3065 1025 1024 7048 56288 7046 60436 5045 7040 54778 9040 56937 7311 100527943 11171 142 904 51377 57154 23645 905 64750 7029 2280 4088 7316 4089 9110 9958 5590 7027 57530 5499 6233 4087 25805 23327 4609 50855 387 4221 10273 7050 6667 51592 6497 50848 5054 6498 892 4092 7323 3726 7321 5500 867 5501 7314 9612 9611 25937 8239 5933 4738 101929368 23370 5494 7514 ESTROGEN BIOSYNTHESIS%REACTOME%REACT_11037.3 Estrogen biosynthesis 1588 3292 SULFIDE OXIDATION TO SULFATE%REACTOME%REACT_116010.1 Sulfide oxidation to sulfate 23474 7263 6821 1468 58472 FORMATION OF APOPTOSOME%REACTOME%REACT_89.2 Formation of apoptosome 317 54205 842 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME%REACT_18342.1 Nucleotide-like (purinergic) receptors 5028 140 5030 27334 2846 53829 9934 64805 5029 10161 136 5031 5032 2840 134 135 POTASSIUM TRANSPORT CHANNELS%REACTOME%REACT_75815.1 Potassium transport channels 3766 3758 3773 NETRIN MEDIATED REPULSION SIGNALS%REACTOME%REACT_22384.1 Netrin mediated repulsion signals 137970 90249 8633 219699 5781 1630 2534 9423 5747 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME%REACT_121329.3 Erythrocytes take up carbon dioxide and release oxygen 760 3040 3043 6005 759 358 762 3039 6521 RMTS METHYLATE HISTONE ARGININES%REACTOME%REACT_228108.1 RMTs methylate histone arginines 8335 8334 653604 8337 1019 8969 86 8331 8329 8332 8358 333932 8330 8352 8359 8353 8336 8354 8338 474382 8357 8356 55170 196528 595 6604 55193 51412 8968 8360 8362 8361 8364 8289 8363 8365 8366 10419 8368 8367 3717 8351 1788 8350 6597 8355 79084 3013 3012 85235 54496 723790 6603 126961 8294 6601 6602 6605 10498 6595 5931 554313 6599 121504 6598 57492 3015 92815 3014 8370 221613 317772 55352 3276 11091 DOPAMINE RECEPTORS%REACTOME%REACT_16968.1 Dopamine receptors 1815 1816 1813 1814 1812 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_115854.1 GRB2 events in ERBB2 signaling 7297 3084 685 5604 5605 2064 7529 1950 3845 4893 3569 3717 3265 3570 9542 145957 3716 6654 10718 1956 5595 5781 2069 983 1839 5594 5894 CLATHRIN DERIVED VESICLE BUDDING%REACTOME%REACT_19187.1 Clathrin derived vesicle budding 85390 164 162 408 85389 1785 1362 10618 1174 100500810 3482 7164 7163 2799 10717 388552 375 6456 5286 152503 8546 51429 8673 27131 2647 6810 9026 130340 26258 25977 8907 286451 8905 81567 8301 3312 54885 2495 84062 4074 55330 23557 2580 5878 1522 2512 7037 9685 10053 1176 4952 6845 6643 8729 1777 23431 6272 8773 9698 8775 6844 9829 THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME%REACT_160083.2 The retinoid cycle in cones (daylight vision) 6017 5956 101060233 611 5949 2652 728458 9249 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_111133.1 Growth hormone receptor signaling 1443 1444 6774 8660 6868 2690 2689 1154 2688 5777 9021 5770 3667 5617 3717 8651 5594 6777 4067 6776 5618 5595 1442 8835 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME%REACT_12478.1 EGFR interacts with phospholipase C-gamma 801 805 156 808 1385 5581 5582 3708 3709 1950 107 108 109 5153 1956 112 5335 115 114 111 5577 5137 113 196883 814 5576 5136 5573 5568 5567 5580 5566 3710 5575 5578 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_11057.4 Metabolism of steroid hormones and vitamin D 1081 4036 8029 5443 1584 1585 51144 1586 1583 80765 1588 120227 1589 1591 1594 3292 3290 6716 6715 6770 2638 231 3293 147323 79644 3283 3972 3284 5641 134429 OTHER SEMAPHORIN INTERACTIONS%REACTOME%REACT_19200.2 Other semaphorin interactions 3688 54209 7305 5788 9723 8482 91584 9037 5362 5365 80031 5361 23129 3672 57556 10507 64218 10154 971 TRAFFICKING OF DIETARY STEROLS%REACTOME%REACT_13781.2 Trafficking of dietary sterols 64241 64240 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_22151.1 Transport of nucleotide sugars 55343 23169 10559 347734 84912 7355 11046 51000 100616124 23443 CLEAVAGE OF THE DAMAGED PURINE%REACTOME%REACT_1729.5 Cleavage of the damaged purine 4968 4350 4595 REGULATION OF APOPTOSIS%REACTOME%REACT_13648.3 Regulation of Apoptosis 5711 5710 5714 5713 5719 23198 79658 5062 5715 5716 5701 7311 5696 5687 5695 5700 5694 5717 5718 5688 5689 5720 7316 10213 5698 5699 842 143471 5721 6233 836 693222 90249 9500 219699 26060 1613 23604 1612 10197 5707 1630 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 5684 5683 GLUCOCORTICOID BIOSYNTHESIS%REACTOME%REACT_11036.3 Glucocorticoid biosynthesis 1584 1585 3290 1586 1589 3283 3284 5443 EICOSANOIDS%REACTOME%REACT_13645.3 Eicosanoids 66002 4051 6916 57834 1580 126410 1579 5740 8529 11283 284541 1582 DARPP-32 EVENTS%REACTOME%REACT_15334.1 DARPP-32 events 801 805 808 84152 5519 5518 5534 1020 5515 5516 5528 5142 5141 5530 5143 5532 5144 5577 729966 5576 5573 5533 5568 5567 5566 5499 5575 FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME%REACT_1966.3 Formation of editosomes by ADAR proteins 104 103 NON-CODING RNA METABOLISM%REACTOME%REACT_11052.2 Non-coding RNA Metabolism 6606 51808 9631 96764 11218 53371 10762 6607 4927 6628 10419 5903 8086 8021 55746 129401 7175 9883 6634 6633 6635 1207 6636 79084 8480 22916 6637 10073 9688 4686 79760 23225 25929 79833 50628 23165 9972 11097 57122 6632 23279 8487 79902 23511 79023 23636 348995 NEURONAL SYSTEM%REACTOME%REACT_13685.3 Neuronal System 6616 777 773 6857 784 785 782 783 1144 55584 2897 51764 2898 80852 88 1146 1145 27092 2791 816 817 818 10142 100507353 101929306 23426 815 2892 1135 2891 5923 2905 1134 1136 2906 1137 57030 2901 1139 2744 10681 27345 2903 2893 27094 2752 2899 1138 8973 6237 83795 89822 83988 3754 10369 56659 10368 3752 1741 3751 1742 5579 3758 1143 3757 6195 3756 1141 3755 1142 338567 3764 6197 131096 4646 9132 2900 6196 348980 2890 4747 9463 2036 60482 84254 27165 1739 89832 4905 3782 3781 10021 160 3783 3739 610 3738 3737 9424 3736 27012 3750 9196 51305 3748 10089 57657 8514 9312 23415 3787 3786 23416 3785 3784 3788 170850 56479 93107 3775 3777 3780 10242 59345 3744 3746 81033 3749 3743 7881 26251 3741 3742 90134 169522 27133 27330 3779 101930324 3778 59283 2785 2786 2783 3760 3761 2784 2787 5330 2788 2560 2561 2562 2569 5331 2567 2566 100996843 200959 2557 2554 6582 2556 3759 55970 2559 107 2558 6580 10060 108 54331 2793 109 2771 2792 2790 2770 3768 3766 100134444 3763 3765 2782 3772 6539 6538 9568 3762 24145 2774 2550 2555 55879 2773 3767 43 6844 6804 3790 5582 2902 2904 54207 50801 3265 9254 3776 112 115 114 94235 3773 111 113 346562 23229 196883 2570 814 23236 5894 5578 801 805 808 1385 18 7915 101060747 4193 5170 673 1312 6531 4128 5594 85390 590 85389 9495 6505 6506 80331 6512 6572 2572 2571 5568 5567 6571 217 5566 54407 81539 10052 56666 774 55799 3747 3745 6529 8541 8499 6540 9256 8224 3312 5924 22999 6511 8497 10497 6853 6507 6854 5864 8500 140679 10815 3770 6833 1103 84694 57369 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME%REACT_21308.2 MAP kinase activation in TLR cascade 5604 5605 3569 3570 9261 3656 23118 5781 1845 1848 3654 1849 466 1846 2353 10454 100996792 64127 5608 983 7867 5598 5599 7189 5606 9252 7297 1385 5601 5602 10392 1386 2002 8767 1432 257397 3725 6416 5519 4205 5518 5515 4208 5516 3717 3716 5595 5600 5528 8517 6195 6197 6196 5594 5609 6885 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_120850.6 TGF-beta receptor signaling activates SMADs 25805 23327 7048 7046 7040 5045 10273 9040 56937 7311 11171 4092 51377 57154 23645 64750 5500 867 5501 7314 2280 4088 4089 7316 9110 9958 4738 101929368 5499 4087 7514 6233 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME%REACT_1221.3 CDK-mediated phosphorylation and removal of Cdc6 5711 5710 1017 5714 5713 5719 23198 5715 5716 5701 7311 5696 5687 5695 5700 5694 5717 5718 5688 5689 5720 7316 10213 5698 5699 143471 990 5721 6233 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 5684 5683 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_118789.3 REV-ERBA represses gene expression 1387 5465 6604 8648 96764 6907 10891 9575 2033 9611 10498 85441 5469 79718 83401 6095 8841 406 6256 23054 9572 10499 80205 4862 NEF MEDIATED CD4 DOWN-REGULATION%REACTOME%REACT_11166.2 Nef Mediated CD4 Down-regulation 375 160 920 101927462 163 100500810 1173 51606 3932 161 1175 TYPE II NA+ PI COTRANSPORTERS%REACTOME%REACT_19411.1 Type II Na+ Pi cotransporters 6569 142680 10568 SYNTHESIS OF PC%REACTOME%REACT_121238.2 Synthesis of PC 126969 64900 80736 590 10390 10400 204962 1103 9663 1120 23175 5130 9468 1119 57153 23446 43 56994 162466 REV-MEDIATED NUCLEAR EXPORT OF HIV RNA%REACTOME%REACT_6190.5 Rev-mediated nuclear export of HIV RNA 9631 53371 5902 10762 4927 5905 55746 8021 8086 5903 129401 7175 9883 8480 5901 9688 23225 9972 23165 11097 1104 57122 23279 79902 23511 79023 348995 7514 23636 MISSPLICED LRP5 MUTANTS HAVE ENHANCED BETA-CATENIN-DEPENDENT SIGNALING%REACTOME%REACT_228096.1 misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling 8335 8334 54894 653604 3065 8337 8331 255626 123169 2535 1857 8358 333932 1856 8352 8359 8353 8354 8338 8339 474382 1855 8357 8356 8347 80351 8348 8345 8346 8340 11197 6259 9101 8343 8344 8341 8342 3021 4609 4040 3020 85236 56998 8968 8360 8362 9736 8361 4221 8364 54145 283149 8363 8295 8365 8366 5519 8970 8368 5518 8349 83999 8367 5515 8085 100616282 5516 8351 8350 4041 8355 5529 3013 5528 3012 5527 5525 8452 723790 126961 5526 8294 554313 121504 3015 3014 84870 8370 3018 3017 8313 55366 59352 340419 7483 607 128312 8323 8325 8321 8322 59349 7015 26108 22943 440193 8549 27123 10524 27121 6422 5534 7534 6423 1387 5530 5532 9070 8290 89780 1455 7514 5711 5710 5714 857 5713 8607 1452 5719 8945 2932 7089 23198 139285 7088 5715 5716 1499 5701 7311 5696 5687 5695 5700 5694 6932 6934 5717 5718 8395 5688 5689 8312 64750 79577 5720 7316 10213 324 5698 83439 9978 5699 7090 7091 10023 143471 5721 6233 801 805 808 101929777 343637 6597 1487 23401 10197 50964 5707 5929 5706 5709 5708 5690 7471 5705 5691 5704 7314 5692 5693 5702 7473 7474 7478 122706 7479 5686 5685 5682 9861 9491 51176 5684 5683 23072 84133 331 284654 25776 57680 8658 90780 51339 2033 1454 4775 1459 1457 81847 4773 207 4772 208 1460 7855 79412 54361 80319 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_160089.1 Constitutive Signaling by NOTCH1 HD Domain Mutants 3714 6868 9148 54492 102 7314 4851 142678 7316 7311 182 54567 28514 57534 6233 BASIGIN INTERACTIONS%REACTOME%REACT_12560.3 Basigin interactions 482 5478 483 857 3655 9123 8140 23539 6566 682 6693 9056 9057 3897 3675 481 23759 4312 3688 23657 6520 56301 4099 101929889 101060363 11136 23428 CELL REDOX HOMEOSTASIS%REACTOME%REACT_121394.3 Cell redox homeostasis SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_19351.1 Signaling by Robo receptor 8440 5063 5062 55740 51466 4690 80728 5058 56924 5217 9901 57522 5879 6654 7408 6091 9353 10486 57144 2817 998 10298 25 10487 23122 6092 23332 27 23380 6655 5216 ACTIVATION OF RAC%REACTOME%REACT_19226.1 Activation of Rac 6091 9353 57144 2817 5063 10298 8440 5062 4690 5058 56924 6655 5879 6654 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME%REACT_11082.3 Import of palmitoyl-CoA into the mitochondrial matrix 32 31 5565 5563 788 5467 1381 1382 1375 1376 6256 1374 51422 SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME%REACT_121168.2 Synthesis of PIPs at the ER membrane 285540 5297 55300 22908 TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME%REACT_16963.1 Tachykinin receptors bind tachykinins 6863 6865 6866 6869 6870 OLFACTORY SIGNALING PATHWAY%REACTOME%REACT_15488.3 Olfactory Signaling Pathway 219437 219417 219436 283365 219429 219432 126541 219431 219438 122740 122742 122748 346517 79290 79295 79296 219428 26184 346528 346525 125958 219869 219469 79274 219482 219484 219875 219873 219874 219464 219870 219447 219865 119687 119682 219858 219473 219477 219479 119679 119678 219453 390431 390432 390437 390038 390433 120586 390445 390037 390036 390442 390441 26189 26188 341152 441608 284433 441639 119694 347468 390429 119695 390538 119692 390436 390439 8590 56656 504190 391107 391109 135941 504191 135948 135946 401427 391114 391112 121275 504189 81127 390651 26533 26532 26539 26538 284521 26531 134083 391121 135924 26529 441670 441669 127623 120065 120066 390323 390321 26707 81168 127608 79346 442185 442186 442184 81169 26595 128366 128367 128368 79345 143496 128360 79339 79334 402135 81193 219487 79324 219493 442179 127617 284532 26534 7932 128372 128371 144125 144124 79310 79317 392133 125962 392138 125963 347169 401667 219965 219960 347168 81797 219986 119772 119774 401665 401666 401663 150681 81282 286365 79470 65944 81697 81696 81285 219957 219956 219959 219958 79473 256892 219968 388761 441911 26692 26693 26696 254786 254783 26686 255725 286362 26658 26659 26664 343406 283093 283092 26716 23538 390326 390327 81300 138799 341276 127066 127068 127069 219952 81309 127062 127064 390649 390648 196335 81315 127077 127074 219983 219981 219982 119764 119765 338662 338675 338674 389090 119749 127059 219954 4995 4994 340980 392390 392391 10798 387748 343171 343173 343172 81431 343169 158131 392376 283160 81406 283159 283162 390271 390275 390265 390261 390264 138881 390260 390266 138882 138883 283111 283110 392392 120793 120796 390199 390197 390195 81392 81399 81228 26689 26687 26211 26212 341799 441932 441933 26682 285659 26683 81248 26219 26248 121129 121130 26245 120776 120787 729759 120775 26648 26246 653166 390201 127385 4993 4992 4991 283189 138805 138804 138803 138802 390058 390059 390054 390053 390154 390155 390152 390151 442361 390157 390162 390167 390168 390134 393046 390142 79541 79544 390144 79549 390148 403284 403282 390113 8388 8387 8383 8386 8391 8390 8389 8392 283694 130075 283297 162998 390883 390894 390892 282775 282763 390882 391189 282770 79501 391195 391196 391190 391192 391191 124538 391194 26740 26338 26339 283617 402317 26333 26737 26735 26341 254879 343563 81318 81328 338755 81341 442194 442197 442191 81327 126370 390174 390191 390190 390181 338751 26494 26493 26496 26495 441308 26492 26476 391211 26497 341416 341418 79482 403253 403257 81472 143503 81061 143502 256144 341568 256148 121364 81458 401973 403278 403277 79490 403273 81469 403244 81470 403239 2792 81466 390083 390084 81442 2782 81448 81050 401993 401994 2774 401992 390093 254973 403274 390061 81099 390063 284383 390066 390064 390081 390067 390078 390077 390073 390075 390079 390072 390082 392309 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME%REACT_1484.2 Transcription from mitochondrial promoters 7019 7978 5442 64216 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_683.3 G1 S-Specific Transcription 5422 26271 5111 6241 1719 8900 7084 7298 898 4998 1869 983 8318 81620 7027 990 993 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_111045.2 Developmental Biology 4651 391 4627 5062 80728 9901 7410 7074 8928 7204 26052 8874 6300 25791 1213 1212 29079 7223 2516 7224 5216 6256 57167 1879 1050 6604 7026 5364 79727 5786 63978 9370 688 1959 1052 5087 56924 5217 1211 9423 84891 80205 5595 2034 6237 6091 1741 1630 9353 1742 64344 6195 10486 57144 2817 10298 9862 25 6197 10487 90390 23122 6196 23332 27022 27 7547 5970 4790 1739 3175 6928 390874 256297 8440 3952 51003 4851 4088 137970 4089 8633 285704 6478 148738 56963 116986 27330 6586 6585 6477 4087 130399 1793 7529 3326 5346 1387 55090 1759 2167 8202 10589 7305 5604 55558 5605 2064 8829 100996782 10371 91584 2242 5362 5361 3265 5879 1956 2309 5335 54209 3320 6657 79923 5460 285643 983 84246 5894 7297 59277 96764 7220 3845 4893 3717 8841 9412 7471 6997 55997 4838 79718 3642 5078 50674 8650 55588 83464 51107 1272 8997 9477 51129 6517 10451 102 5664 55851 388 387 91 23396 389 23389 23365 6453 5880 112950 2033 2909 101927462 57522 3312 1459 1457 3516 6654 1051 9439 998 1460 9443 9441 9442 23380 7124 6655 9826 9440 4654 4617 6925 1013 9043 729991 4917 100271849 1019 6938 1496 663 4207 50937 4618 7040 4656 6929 4756 23054 4629 1942 285220 4628 2043 2042 1943 3791 22885 3983 84448 6092 10001 1292 1291 784 4684 785 782 64096 783 1293 1002 81857 4023 1432 284656 6461 103910 79784 10398 57113 4637 2041 1944 2046 1945 2045 1969 1946 2044 5600 7408 3688 1495 1000 7225 5105 9612 7222 9611 9723 4233 10498 8482 5365 80031 23129 57556 10507 64218 10154 4209 971 51586 10499 2657 160 163 6907 161 5046 7480 5045 100507472 9037 3786 8218 3569 3785 2534 3570 6774 5781 1173 5788 101928143 1175 6456 23097 93 92 9350 776 1282 100132336 6900 1298 1285 375790 1284 9048 4902 9282 8128 1297 7903 1287 54797 2674 2675 2668 8911 8912 8913 131873 1299 1463 892 1286 775 101930388 9968 5623 5621 256076 779 9969 24137 23385 1072 2051 3984 3985 60 2047 9475 2049 2932 6093 5063 2048 1947 2902 6721 2904 55740 5747 8976 1949 51466 1499 1948 1809 4690 7525 10570 5058 1808 5921 1400 1020 10093 10092 56896 5588 10552 1785 10097 6383 10096 10094 219541 71 10109 4067 8851 64283 4313 5608 101928625 1385 9855 27289 2247 6327 6329 2255 9314 400569 10891 8506 6709 85441 6708 27255 6710 6712 3672 3673 6334 6332 6331 5594 6711 6328 4478 6326 6335 5465 8986 55800 10048 85390 8515 57731 10752 3280 8828 1024 51332 6386 7430 6324 6323 4318 23114 5962 100133941 1641 3912 214 3897 5469 57698 3678 3690 85389 3685 5468 3915 3630 288 4760 286 287 3674 3170 284217 3680 4897 948 7094 9252 8648 10627 28964 90249 219699 4205 4208 10025 3716 10000 6837 4821 6927 3171 5306 3174 4825 207 208 6514 3375 7044 389692 5080 10637 2308 3651 2645 2050 896 SIGNALING BY GPCR%REACTOME%REACT_14797.5 Signaling by GPCR 219437 6002 391 219417 393 219436 2914 283365 2913 2912 83756 219429 10276 219432 126541 219431 6000 219438 6001 122740 122742 122748 346517 79290 79295 79296 219428 7410 50839 89846 26184 346528 23263 346525 6019 7074 125958 7204 9340 2532 219869 219469 79274 1894 219482 8324 29 5734 219484 8874 7409 5732 2920 219875 219873 219874 219464 219870 25791 2921 219447 219865 119687 119682 219858 219473 219477 219479 7976 2918 119679 3640 119678 2917 2780 219453 2775 2919 2916 390431 390432 390437 5364 390038 390433 120586 5368 390445 390037 390036 390442 390441 26189 50838 50837 26188 50836 10125 341152 5579 50840 441608 6195 50832 50833 50834 6197 50835 50831 284433 6196 976 441639 119694 347468 390429 119695 390538 119692 1815 1816 1813 1814 1812 390436 390439 8590 56656 504190 391107 391109 338557 135941 504191 2922 135948 135946 401427 391114 391112 121275 504189 81127 390651 26533 26532 26539 26538 284521 26531 56670 134083 391121 135924 51052 26529 441670 441669 127623 6364 6363 8601 6361 120065 120066 6366 6367 6752 6753 2841 6360 6751 390323 390321 6750 155 6348 3827 6349 151306 6351 6352 153 154 80835 80834 6356 151 2852 26707 2853 5196 6354 81168 127608 79346 442185 442186 442184 81169 26595 128366 128367 128368 2147 79345 143496 5443 128360 51083 79339 79334 402135 5733 81193 219487 79324 219493 442179 127617 5746 5741 5744 5745 1392 1395 1394 5727 4283 5729 5726 284532 26534 7932 283869 729966 134860 414062 134864 26575 256933 5533 128372 128371 144125 144124 11211 79310 79317 392133 125962 392138 125963 10563 1081 9294 347169 401667 9290 219965 219960 347168 81797 219986 5581 119772 9283 5582 119774 5604 401665 401666 5605 401663 150681 81282 286365 79470 65944 81697 81696 81285 2652 219957 219956 3265 5879 219959 219958 79473 256892 1956 219968 3549 53637 4158 4543 4544 4160 4161 388761 441911 26692 5137 26693 26696 4157 4159 814 254786 254783 1269 10803 27202 983 1268 26686 255725 11343 1839 286362 26658 26659 26664 343406 283093 23236 5894 283092 186 156 26716 187 7297 101929777 2826 2834 2833 2832 2831 6372 6370 6374 2641 6373 2642 23538 6376 390326 390327 84152 3845 8622 136 4893 611 133 51384 81300 101060747 3717 3062 134 117579 138799 5170 8643 10850 341276 6754 6755 127066 127068 127069 219952 81309 140 127062 127064 7471 2863 2861 7476 390649 390648 196335 81315 127077 127074 219983 7473 9288 219981 7474 219982 7477 119764 7478 119765 9287 7479 7472 338662 338675 338674 389090 119749 7475 127059 219954 9628 100996542 160851 4995 5583 9002 4994 340980 846 1241 392390 57121 392391 3814 10798 387748 1133 431704 343171 84109 343173 2915 343172 139189 81431 2911 343169 60675 339403 84432 158131 392376 84634 115557 2768 9170 2796 283160 128674 81406 259287 185 283159 2828 259289 2829 10287 259286 799 10886 10316 797 83551 624 10800 259285 2798 259296 2797 259291 2781 23620 259295 10887 8997 259293 146850 2867 6863 259292 283162 2865 259294 8477 26230 6915 390271 347148 11214 259290 3061 57449 390275 2869 10451 390265 257313 64857 58191 23566 2693 390261 5724 390264 138881 5997 390260 2862 3060 390266 57105 138882 387129 138883 283111 29933 2520 283110 392392 146 120793 147 120796 148 9138 2925 353164 64106 390199 594857 390197 1609 390195 1607 81392 1608 5499 4889 6846 1234 4886 1606 4887 8620 81399 221955 7252 81228 2245 680 7432 8527 10022 2150 7433 221472 886 7434 388 885 8526 387 27237 26689 8525 26687 6865 389 26211 6866 26212 23365 6869 341799 747 6453 441932 6870 5880 441933 2149 26682 5731 285659 5737 26683 81248 26219 1237 1238 1233 1236 5697 1232 5924 26248 121129 6343 6344 1230 121130 4168 26245 6654 8698 120776 6375 120787 9162 729759 56413 120775 623 26648 10874 26246 129521 653166 2837 9181 1128 51289 7201 998 719 7200 1910 390201 1131 56923 338398 64407 27199 1908 728 121512 127385 2847 319100 10911 1906 7855 9828 4993 4992 5367 1907 4991 1909 8484 101930241 165140 222545 8111 1902 283189 50649 4295 6655 54361 84033 138805 4828 9826 138804 3972 4829 23370 138803 4922 80326 50650 138802 114814 4987 887 84539 7852 4988 4985 2151 4986 4923 390058 390059 390054 390053 10203 79924 390154 390155 390152 390151 442361 390157 390162 390167 390168 390134 3579 3577 393046 11251 390142 101060233 79541 643 79544 390144 2535 79549 390148 9034 403284 9038 403282 10672 390113 100996758 8388 8387 8383 8386 8391 8390 8389 6347 8392 283694 1524 130075 796 283297 162998 8811 10636 390883 3576 390894 390892 10663 282775 282763 390882 59350 2776 391189 8862 282770 8326 79501 391195 391196 391190 391192 9459 391191 2740 2015 728458 84658 124538 8786 8787 391194 57007 5999 5996 5150 26740 26338 26339 2767 283617 2769 56477 50846 402317 26333 1132 26737 27115 1129 5151 26735 26341 54429 5142 254879 5141 5143 343563 5144 2692 5294 81318 81328 2691 30817 5539 5173 5179 338755 4852 81341 442194 442197 442191 27198 338442 81327 2696 8843 6608 126370 390174 390191 390190 390181 338751 7480 7481 7482 7483 7484 8323 8325 5660 8321 8322 26494 26493 26496 26495 441308 26492 26476 391211 100505585 5473 85397 26497 341416 341418 79482 403253 403257 81472 4314 5956 143503 81061 1903 122042 143502 1901 256144 341568 256148 121364 81458 401973 403278 403277 5534 79490 10268 51554 403273 81469 403244 10266 10267 81470 403239 81466 390083 390084 2587 113091 5530 3627 5532 81442 81448 81050 401993 401994 401992 390093 254973 403274 390061 81099 390063 284383 390066 390064 89780 390081 390067 390078 390077 390073 390075 390079 390072 390082 392309 9630 2779 5588 2864 6010 801 805 808 1385 183 23533 150 152 3973 2492 7253 5594 6469 5577 5576 5573 5568 5567 5566 551 554 5575 10235 729230 8503 1235 5595 727 718 1604 5330 5332 5331 7529 553 5020 552 5580 5578 6387 5028 5030 27334 2846 53829 9934 64805 5029 10161 5031 5032 2840 5021 51764 2791 3708 3709 5140 5138 5519 5139 5518 5515 5516 57113 2778 10681 5153 10846 5528 2488 7225 7222 3569 3570 5290 5781 59345 5136 5321 3710 5739 50940 2785 2786 2783 2784 2787 2788 55970 107 108 54331 2793 109 2771 135 2792 117 2790 116 2770 2782 9568 2774 2550 2773 9475 6093 59340 3274 11255 3269 1020 112 115 114 94235 111 113 346562 23229 196883 2695 5598 23596 3354 3358 3357 3350 3360 3361 3362 3363 3352 3356 3351 3355 5995 221391 94233 10692 6288 351 5296 2358 2359 301 2357 3716 50865 5295 10000 207 208 3375 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME%REACT_733.3 Removal of aminoterminal propeptides from gamma-carboxylated proteins 8858 5624 2158 2155 2147 2159 5627 2621 5045 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_163993.2 IRF3-mediated induction of type I IFN 147945 51428 7520 2547 81030 3428 340061 11277 5591 84126 3661 4361 29110 23220 ELASTIC FIBRE FORMATION%REACTOME%REACT_150366.2 Elastic fibre formation 100505984 3696 3694 2200 7040 5045 8516 8200 3678 3690 3685 2202 8425 4052 4054 4053 2199 2192 8076 10516 4236 4237 30008 7448 4238 4239 3688 652 4015 655 4016 27302 84171 4017 84467 84695 645832 650 7043 7042 2201 2006 3693 MMR%REACTOME%REACT_228013.1 MMR 5111 4436 4437 6119 6118 57804 6117 5425 5424 4292 3978 10714 5395 2956 9156 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_9390.4 FGFR2 ligand binding and activation 2247 2246 2249 2255 8823 27006 2251 2252 2254 2248 8817 8074 26281 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME%REACT_19400.2 Golgi Associated Vesicle Biogenesis 85390 164 162 408 85389 1785 1362 10618 3482 100500810 1174 7164 7163 10717 388552 375 6456 5286 152503 8546 51429 8673 27131 2647 9026 130340 26258 25977 8907 8905 286451 81567 8301 3312 54885 2495 84062 55330 23557 2580 5878 2512 7037 9685 10053 1176 4952 6845 6643 23431 6272 9698 8775 6844 9829 INTERCONVERSION OF POLYAMINES%REACTOME%REACT_14805.2 Interconversion of polyamines 6303 54498 196743 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_9508.3 FGFR3b ligand binding and activation 2246 26281 2254 8817 TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME%REACT_75850.1 TWIK-related alkaline pH activated K+ channel (TALK) 83795 89822 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME%REACT_204.3 ATM mediated response to DNA double-strand break 672 472 9656 4683 3014 DISSOLUTION OF FIBRIN CLOT%REACTOME%REACT_641.2 Dissolution of Fibrin Clot 5329 5271 5270 3273 5269 5055 5327 5340 6281 5345 5054 5328 302 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME%REACT_228019.1 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 5111 4436 4437 6119 6118 57804 6117 5425 5424 4292 3978 10714 5395 9156 G1 S DNA DAMAGE CHECKPOINTS%REACTOME%REACT_2254.3 G1 S DNA Damage Checkpoints 5711 5710 1017 5714 5713 5719 9134 23198 898 5715 5716 5701 7311 5696 5687 1026 5695 5700 5694 5717 5718 5688 1111 5689 1027 5720 7316 64326 10213 5698 5699 143471 993 5721 6233 7157 4193 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 122706 472 5686 5685 5682 9861 9491 5684 5683 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_111119.1 Antigen processing-Cross presentation 5711 5710 5714 5713 5719 23198 5715 5716 1535 5701 7311 5696 1536 5687 567 5695 5700 653361 3685 10952 5694 5717 5718 5688 4689 5689 4688 948 3133 4012 5720 7316 10213 5698 3107 5699 3106 2923 143471 3693 5721 6233 1520 23480 1514 9902 6891 4360 1515 811 50489 6890 55176 6892 3105 29927 100132417 101928757 3135 10197 5707 5706 5709 5708 5690 5705 5691 5704 3134 7314 5692 5693 5702 2210 122706 2209 5686 5685 5682 9861 9491 5684 5683 INTERFERON SIGNALING%REACTOME%REACT_25229.1 Interferon Signaling 3115 115361 100509457 6672 3117 3119 3118 10437 388646 4261 26781 4502 163351 100507709 2633 3113 2635 6043 115362 7311 3122 5696 55746 100996809 100507714 101060835 3120 3123 5335 23586 3133 3665 7316 5580 3661 3125 3107 3126 3106 3127 8651 4684 7706 7334 6233 7297 677847 816 7412 817 818 815 3383 8021 3717 4599 3105 7175 6773 9883 1981 3433 3434 8638 100132417 5595 10581 3437 3135 10379 3394 4938 4939 5495 4600 3662 8519 1958 54739 3454 7314 3134 6041 11274 960 23225 4940 10410 3839 51447 2210 9021 3430 3838 3459 3841 3429 3460 3840 2634 2537 1982 2317 2209 11097 5770 3663 3669 25820 3664 373856 9470 8672 402569 8554 23511 3458 317649 23636 7324 51191 10762 567 619567 619568 5903 7318 100302143 6772 8480 7341 5781 1974 1973 1977 5724 100847079 5777 23165 5300 23279 79902 348995 9246 652965 652966 9636 9631 53371 103 4927 5610 8086 129401 3442 3440 3716 3441 4734 3439 3451 3443 3836 3444 9688 3452 3448 3449 3445 3446 3837 3660 9972 3659 57122 3456 5371 9775 79023 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_9413.3 FGFR2c ligand binding and activation 2247 2246 2249 8823 26281 2251 2254 8817 8074 THE ROLE OF NEF IN HIV-1 REPLICATION AND DISEASE PATHOGENESIS%REACTOME%REACT_6835.4 The role of Nef in HIV-1 replication and disease pathogenesis 160 940 164 163 162 130340 5062 161 926 8907 8905 567 920 101927462 2534 1794 3105 5879 9844 100996919 3055 1174 100500810 10053 1173 51606 1175 375 3932 55690 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_160248.1 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 3066 3714 6868 3065 3280 6907 54492 1024 7089 408 409 7088 23462 6500 3091 7311 2648 8650 83464 113878 10014 51107 1272 8454 9794 26508 10013 102 84441 101928143 23493 4851 8788 5664 7316 142678 22938 9759 9978 10046 7091 54567 57534 83737 6233 51564 55851 79885 4609 9148 2033 55869 55534 182 892 8841 101930388 3516 28514 388585 83933 9734 1387 7314 9612 9611 92737 1840 8850 79718 23220 23385 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_163834.2 FCERI mediated Ca+2 mobilization 801 9402 805 808 3539 3497 28916 3702 28442 100423062 7006 28454 3708 3542 3709 28912 5534 3514 6850 7410 28776 4775 28876 4067 6654 28874 3937 5530 4773 5335 5532 4772 5336 7409 10451 28908 28299 695 7294 28896 3710 28834 3538 440786 INTEGRATION OF VIRAL DNA INTO HOST GENOMIC DNA%REACTOME%REACT_8990.2 Integration of viral DNA into host genomic DNA 3159 11168 8815 HYPUSINYLATION%REACTOME%REACT_12469.1 Hypusinylation 1984 83475 1725 56648 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_169429.2 Defects in cobalamin (B12) metabolism 55191 4552 1719 4548 32 4594 31 23475 9446 5743 5646 8029 5645 55229 5644 25974 55312 81034 316 53354 55163 8034 6947 10560 55034 81693 9962 3141 9963 56922 60496 60490 27010 8566 166785 23057 5095 326625 5096 101929880 440387 101928493 6948 6470 1504 51293 349565 80025 64087 4338 27249 4524 54 6573 51248 113278 80347 101928717 2694 5091 4522 119391 113235 27304 65220 80704 79178 200895 6515 6513 93100 5167 55788 8884 80308 5740 1528 79717 4363 1582 2194 1727 10135 686 64802 10243 79646 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_147841.3 STING mediated induction of host immune responses 147945 51428 6778 6737 115004 7520 2547 81030 3428 340061 11277 5591 84126 3661 4361 29110 23220 METABOLISM OF MRNA%REACTOME%REACT_20605.3 Metabolism of mRNA 6231 6232 54512 9125 6044 23049 100505503 6043 167227 22894 116936 116938 6228 6229 6227 6235 4736 6230 6234 84546 23404 2197 1656 23016 25904 22794 1994 9887 677847 51690 6224 6223 23293 6222 1432 23019 6203 6201 6202 5518 5515 3842 1981 11340 5600 6210 6205 6204 6208 6209 6206 6207 6217 6218 3921 56915 6137 9939 6136 6138 6139 101060386 6130 6133 6132 6135 6134 6143 6144 6141 6142 7538 6147 606500 6146 55181 9261 552900 4116 11224 1974 1973 23381 1977 1975 56006 6129 6128 4848 4849 5520 4850 6124 6123 25804 6122 6125 574040 219988 619505 7529 6176 6175 7534 196513 26795 3303 10921 55802 6418 51010 4686 51013 29883 26986 3304 7514 5711 5710 5714 55571 5713 5393 5719 23198 26784 26781 5715 26780 5716 5701 7311 5696 5687 5695 26778 5700 5694 5717 5718 5688 26771 5689 8741 5976 26809 25873 54464 100124516 23658 5720 7316 10213 5580 5698 5699 8570 94163 26791 143471 5721 26790 6233 5578 23644 255967 10605 8021 23521 595100 55110 22916 10197 5707 5706 5709 5708 5690 5705 85456 5691 5704 7314 5692 5693 5702 8125 122706 5686 5685 5682 9861 9491 6083 5684 5683 6165 6168 9924 85390 6161 27257 2107 6164 6160 27258 9045 101929876 6167 6169 85388 28960 619567 619568 85389 619565 619499 619562 100302143 100529097 118460 101060589 26819 26815 57472 26817 26818 26816 51121 6193 6194 6192 6191 26019 246175 26820 652965 652966 9349 6171 11157 6170 6173 57819 100526842 26811 3312 26814 6189 6188 9337 3315 6187 595097 595099 207 100996747 100508408 6181 80153 65110 595098 677 23708 5073 6154 6155 6152 9775 6159 8944 6157 6158 65109 6156 REPRESSION OF WNT TARGET GENES%REACTOME%REACT_228106.1 repression of WNT target genes 1487 1488 3065 7089 7088 1499 83439 166 6932 6934 7090 7091 51176 DNA REPLICATION%REACTOME%REACT_383.6 DNA Replication 5711 5710 1017 5714 5713 5719 23198 5715 5716 5701 7311 5696 5687 1026 5695 3978 5700 5694 5717 5718 5688 5689 1027 51343 5111 51659 8900 5982 5981 5983 2237 5001 4999 5000 4998 9837 4171 5720 7316 5426 10213 5425 4176 5698 5424 890 4174 5699 4175 5985 5984 1763 23595 143471 990 5721 6233 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 5684 5683 51053 5925 1871 1870 55388 8317 10926 29935 6119 6118 6117 5422 84515 4173 23594 4172 5427 23649 84296 5557 57804 5558 1869 8318 10714 81620 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_6960.4 Glutathione synthesis and recycling 2679 124975 2729 55748 91227 92086 2937 2678 79017 26873 2686 2687 728441 2730 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_13673.1 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 3175 6928 390874 3280 50674 3516 4851 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_160158.2 Role of phospholipids in phagocytosis 2212 101930374 5337 3539 2214 5338 122618 28916 28442 5581 100423062 28454 3708 3542 3709 28912 5291 3514 6850 5296 917 28776 3502 3503 28876 5290 3501 5295 23646 28874 5335 5336 84513 28908 28299 28896 2210 5580 2209 3710 28834 3538 8398 196051 440786 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_19358.4 CD28 dependent PI3K Akt signaling 253260 10000 940 207 208 9020 942 941 64223 2475 101060747 2534 5296 3932 117145 5170 79109 57761 1326 5290 8503 5295 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_111158.1 ABCA transporters in lipid homeostasis 215 10349 21 5825 10347 335 64137 23460 9619 10350 8504 225 64241 26154 5824 64240 20 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME%REACT_12583.1 VEGF binds to VEGFR leading to receptor dimerization 7422 3791 7423 2277 5228 2321 2324 7424 GLYCOLYSIS%REACTOME%REACT_1383.7 Glycolysis 2023 7167 5214 229 226 2027 2026 2597 5223 5519 5224 5518 5515 5516 2821 5528 5230 5213 5210 5208 5207 230 26330 5211 5209 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME%REACT_13796.2 Amino acid transport across the plasma membrane 153201 6533 340024 117247 8140 6541 9056 9057 92745 54716 6510 206358 55089 10991 23657 6509 6539 55117 84889 6520 11254 6519 124935 56301 54407 348932 81539 8501 11136 23428 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_20593.2 Post NMDA receptor activation events 801 805 808 1385 88 816 817 2902 818 10142 2904 815 5923 2905 101060747 107 5924 2906 3265 2903 109 5170 6237 1742 114 673 6195 6197 6196 4747 814 5568 5567 5566 5594 84254 27330 5894 MTORC1-MEDIATED SIGNALLING%REACTOME%REACT_6964.2 mTORC1-mediated signalling 1978 29904 6198 6194 64223 2475 1977 101930123 1975 1981 6009 57521 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_172694.2 beta-catenin independent WNT signaling 5711 5710 5714 5713 5719 23198 5582 5715 5716 1499 5701 7311 5696 5687 5695 5700 5694 5158 6932 2535 6934 5717 5879 5718 5688 5689 5145 64750 1857 1856 8324 144165 23513 94235 5148 26523 1855 4919 5720 1213 7316 1212 10213 5592 5698 83439 5699 7976 23002 5216 6259 57216 2780 143471 2775 5721 51701 23236 6233 4920 5578 801 5593 805 51764 808 50855 2791 3708 3709 815 1211 10681 23112 10197 5707 5579 5706 5709 5708 7471 5690 5705 5691 5704 7314 5692 5693 5702 7474 122706 5686 5685 5682 9861 9491 51176 6885 5684 5683 160 163 409 161 7481 27161 8323 8325 8321 8322 57154 4343 59345 1173 81029 1175 3710 2785 2786 2783 2784 387 2787 2788 5330 57690 5881 5331 5880 5534 55970 101927462 54331 2793 192669 2792 2790 192670 5530 5532 4772 2782 7855 27327 54361 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_6781.3 APC C:Cdc20 mediated degradation of mitotic proteins 5711 996 5710 5714 5713 7324 5719 9184 991 23198 5715 5716 9232 5701 7311 5696 5687 5695 730268 5700 5694 51433 5717 5718 5688 5689 11065 891 29882 246184 8697 29945 4085 5720 7316 10213 51529 5698 983 5699 143471 701 5721 10393 6233 51434 10197 5707 5706 5709 5708 5690 5705 7321 5691 64682 5704 7314 5692 5693 5702 8881 122706 5686 5685 5682 9861 9491 5684 5683 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%REACT_15312.2 Adenylate cyclase activating pathway 112 115 107 114 108 111 2774 113 109 196883 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME%REACT_18290.1 Calcitonin-like ligand receptors 796 10203 79924 133 10268 799 3375 797 10266 10267 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME%REACT_9047.5 Toll Like Receptor 9 (TLR9) Cascade 8411 5604 5605 7311 3569 3570 54106 9261 3656 23118 51295 7336 1845 5781 64145 1848 3654 51284 1849 6288 466 1846 2353 10454 100996792 170506 3665 7316 246330 64127 5289 5608 7867 983 6285 4791 5598 177 30849 5599 1660 7334 7335 1147 51311 6283 6233 7189 5606 9252 7297 4214 1385 5601 57161 5602 10392 1386 51135 57162 3146 2002 8767 1432 4615 257397 5519 3725 6416 5518 4205 351 5515 5516 4208 3717 3716 5595 5600 5528 8517 6195 6197 7314 6196 5970 5594 4792 4793 5609 4790 6885 3551 ENDOGENOUS STEROLS%REACTOME%REACT_13812.3 Endogenous sterols 10858 8648 5740 1545 1582 9420 5443 1584 1585 1586 1583 1581 1588 9971 1589 1595 6256 51302 10499 1593 SPERM:OOCYTE MEMBRANE BINDING%REACTOME%REACT_164006.2 Sperm:Oocyte Membrane Binding 113177 928 100129669 284359 126123 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_115720.1 PLCG1 events in ERBB2 signaling 801 805 156 808 1385 5581 5582 3708 3709 2064 1950 107 108 109 5153 1956 112 5335 115 114 111 5577 5137 113 196883 814 5576 5136 5573 5568 5567 5580 5566 3710 5575 5578 NS1 MEDIATED EFFECTS ON HOST PATHWAYS%REACTOME%REACT_6222.4 NS1 Mediated Effects on Host Pathways 8106 5610 10898 PEPTIDE CHAIN ELONGATION%REACTOME%REACT_1404.2 Peptide chain elongation 6231 6232 6044 26784 100505503 26780 7311 116936 116938 26778 6228 6229 6227 6235 4736 6230 26771 6234 84546 26809 25873 2197 100124516 94163 26791 26790 6233 6224 6223 6222 6203 6201 6202 23521 595100 6210 6205 6204 6208 6209 6206 6207 6217 6218 3921 6083 6165 6168 6137 6136 6161 6138 6164 6139 6160 6130 6133 9045 6132 6135 6167 101929876 6134 6169 85388 6143 6144 6141 6142 6147 606500 6146 619565 619499 619562 11224 100529097 26819 26815 26817 26818 26816 6129 51121 6128 6193 6194 6192 6191 26820 6124 1915 6123 6122 6125 9349 6171 574040 6170 6173 619505 6176 100526842 6175 26811 26814 6189 6188 26795 6187 595097 595099 1938 100996747 100508408 6181 595098 6154 6155 6152 6159 8944 6157 6158 6156 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_7999.3 Removal of the Flap Intermediate from the C-strand 5111 5425 5424 10714 2237 1763 6119 6118 57804 6117 METABOLISM OF SEROTONIN%REACTOME%REACT_15532.2 Metabolism of serotonin 217 4128 MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME%REACT_610.2 Mitochondrial transcription termination 7978 EPH-EPHRIN SIGNALING%REACTOME%REACT_228170.1 EPH-Ephrin signaling 1072 2051 3984 3985 160 4627 60 2047 9475 2049 163 6386 6093 8440 2048 5063 1947 2902 5062 4318 161 2904 5747 8976 1949 1948 7525 5058 5921 10093 83464 8218 10092 10552 2534 51107 10097 6383 7410 3265 10096 5879 10094 71 10109 4067 7074 64283 4629 8997 1942 285220 4628 2043 2042 8874 1943 3320 3791 10451 1173 102 4313 25791 1175 5664 1213 1212 55851 387 6453 10627 28964 284656 6461 103910 101927462 79784 10398 1211 4637 2041 1944 2046 1945 2045 1969 1946 2044 1759 998 2050 23385 VPR-MEDIATED NUCLEAR IMPORT OF PICS%REACTOME%REACT_7991.2 Vpr-mediated nuclear import of PICs 9631 53371 3159 10762 4927 55746 8021 8086 5903 129401 9883 7175 11168 8480 3836 9688 23225 9972 23165 11097 57122 23279 79902 23511 8815 79023 348995 23636 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_160156.2 The canonical retinoid cycle in rods (twilight vision) 6017 9227 5959 121214 6010 4647 8630 222236 157506 51109 6121 5947 145226 5949 7276 5950 101927965 50700 64220 8608 10170 24 3292 TIE2 SIGNALING%REACTOME%REACT_12621.4 Tie2 Signaling 51378 5781 7010 3845 285 5291 284 9046 4893 2886 5296 3265 6464 5290 6654 5295 2888 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_120916.3 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 2034 7323 7428 54583 112398 8453 112399 64344 7322 7321 7314 3091 7316 7311 6921 6923 9978 6233 PROCESSING-DEFECTIVE HH VARIANTS ABROGATE LIGAND SECRETION%REACTOME%REACT_228190.1 Processing-defective Hh variants abrogate ligand secretion 5711 5034 5710 5714 6868 5713 5719 23198 5715 5716 5701 7311 5696 7415 5687 5695 5700 6469 5694 5717 5718 5688 5689 3549 5720 7316 10213 5698 5699 143471 5721 6233 6400 51009 27248 50846 147111 2262 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 122706 84447 5686 5685 55733 5682 85455 9861 57758 9491 5684 10956 5683 GLUTATHIONE CONJUGATION%REACTOME%REACT_6926.5 Glutathione conjugation 2679 2729 55748 9446 91227 2678 2946 79017 2949 26873 221357 27306 2730 124975 2954 2952 653689 2953 2947 2948 2941 2938 2944 2939 92086 2940 2937 4258 2686 2950 2687 728441 119391 4259 4257 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_13462.2 Activation of DNA fragmentation factor 3009 3007 3008 3024 836 3836 3146 3005 3006 3837 3148 1676 1677 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME%REACT_494.1 Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis 857 5568 5567 5566 3991 5346 11343 51099 5500 5501 2167 5499 PD-1 SIGNALING%REACTOME%REACT_19324.1 PD-1 signaling 3115 100509457 3117 28577 3119 3118 916 915 5133 100507709 80380 29126 3113 3122 920 917 100996809 100507714 101060835 3120 3123 28639 5781 5777 28755 3125 1445 3126 3127 3932 HSF1 ACTIVATION%REACTOME%REACT_200744.2 HSF1 activation 1915 7415 3281 3297 10728 7531 3326 3320 10013 6119 6118 6117 TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME%REACT_23809.2 Transport of glycerol from adipocytes to the liver by Aquaporins 100509620 364 366 101930168 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_121025.2 Synthesis of PIPs at the plasma membrane 23396 51763 8871 8867 5291 5293 5296 5288 5728 8776 5287 8395 5290 23533 8503 5295 146850 5294 27124 3631 285540 9107 8897 5286 8821 8394 55300 4534 3635 8396 3636 5305 64419 55361 FORMATION OF HIV-1 ELONGATION COMPLEX CONTAINING HIV-1 TAT%REACTOME%REACT_6346.5 Formation of HIV-1 elongation complex containing HIV-1 Tat 728340 1022 2968 2967 1025 5438 100126332 5439 5436 902 5437 5434 5435 8178 5431 5433 904 5430 5432 22916 2962 6749 2963 7469 5440 6829 100302242 25920 5441 11198 4331 4686 6827 7936 2068 9150 2071 6921 6924 6917 6923 2965 51497 2966 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME%REACT_1913.2 RNA Polymerase I Promoter Escape 728340 64425 692063 1022 2968 2967 100302240 84172 902 30834 5437 5434 5435 654320 221830 9015 25885 51082 9013 692072 5440 9014 677822 677805 5441 9533 4331 7343 677792 2068 2071 6908 79101 10849 54700 2965 2966 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_160125.4 Visual phototransduction 336 337 2239 121214 26020 3949 9249 83875 3339 51109 6295 2779 10988 221914 9397 2979 101060233 2978 5588 5158 2652 6383 2339 23173 345 2342 64220 388531 348 9626 10170 5145 3292 100529261 344 9227 335 5957 338 2986 6010 6011 1258 5148 1259 3000 2719 4836 5475 57016 6121 1645 145226 29967 50700 101927965 7804 5578 6017 801 805 808 5956 5959 4036 375790 728458 4035 222236 4023 9672 6382 151056 6385 5948 611 5947 5949 5950 8644 1109 2792 1208 24 2262 9187 2782 2817 4647 8630 157506 10082 5406 7276 8608 53630 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200856.2 NoRC negatively regulates rRNA expression 3066 728340 8335 8334 1022 653604 3065 8337 11176 8331 902 30834 255626 8358 333932 8352 8359 9013 8353 8354 9014 8338 8339 677805 9533 474382 4331 8357 8356 8347 8348 8345 7270 8346 6908 8340 79101 10849 8343 8344 8341 8342 3021 64425 3020 692063 85236 2968 2967 8968 8360 8362 8361 100302240 84172 8364 54145 8363 8365 8366 8970 8368 8349 8367 100616282 8351 654320 8350 9015 25885 8355 3013 3012 51082 692072 5440 677822 8932 723790 5441 126961 8294 7343 677792 2068 2071 554313 121504 3015 3014 8370 3018 2965 2966 3017 23309 51742 5437 5434 5435 128312 221830 8467 8819 29115 79685 1786 64426 1789 10284 79595 25942 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME%REACT_14819.4 Peptide ligand-binding receptors 9283 729230 3579 3577 553 643 5020 552 9034 6019 2532 4158 100996758 4160 4161 2920 6347 2921 4157 1524 4159 8811 10803 1235 27202 3576 10663 3640 59350 2919 8862 186 187 2826 2834 2833 2832 2831 5368 6372 6370 6374 6373 183 57007 6376 56477 3062 117579 10850 6754 6755 6387 2861 5539 5173 5179 4852 9002 3814 2922 84109 60675 339403 84432 84634 128674 185 727 2829 10886 718 10316 5660 51052 624 23620 10887 6364 6863 6363 6361 347148 3061 6366 6367 6288 257313 6752 58191 6753 2693 6360 6751 2862 3060 6750 387129 6348 3827 6349 6351 6352 2925 551 64106 554 594857 6356 5473 6846 4889 2852 1234 4886 8620 4887 5196 6354 680 10022 2150 886 885 6865 6866 122042 6869 6870 2147 2149 5443 51083 1237 1238 1233 351 1236 51554 5697 1232 2358 2359 301 2357 1230 50865 6375 2587 623 10874 4283 3627 129521 2837 5021 51289 7201 7200 719 1910 283869 56923 1908 728 414062 2847 10911 1906 5367 256933 1907 8484 1909 4295 4828 4829 4922 4987 887 4988 7852 84539 4985 2151 4986 10563 4923 TOXICITY OF BOTULINUM TOXIN TYPE D (BONT D)%REACTOME%REACT_200617.2 Toxicity of botulinum toxin type D (BoNT D) 9900 9899 22987 6843 6844 REGULATION OF DNA REPLICATION%REACTOME%REACT_829.4 Regulation of DNA replication 5711 1017 5710 51053 5714 5713 5719 23198 5925 5715 5716 5701 7311 5696 5687 1026 5695 5700 5694 5717 5718 1871 5688 1870 5689 1027 51343 55388 8900 5001 4999 5000 4998 4171 5720 7316 10213 4176 5698 890 4174 4175 5699 23595 143471 990 5721 6233 84515 4173 23594 4172 1869 81620 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 5684 5683 INFLAMMASOMES%REACTOME%REACT_75900.1 Inflammasomes 598 596 22861 10628 114548 9447 29108 24145 7295 834 9051 58484 5027 10910 351 4791 3326 5970 4790 4210 TRYPTOPHAN CATABOLISM%REACTOME%REACT_916.5 Tryptophan catabolism 23498 56267 169355 125061 3620 883 8942 8564 51166 130013 6999 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_20549.1 Autodegradation of the E3 ubiquitin ligase COP1 5711 5710 5714 5713 5719 23198 5715 5716 5701 7311 5696 5687 5695 5700 5694 5717 5718 5688 5689 5720 64326 7316 10213 5698 5699 143471 5721 6233 7157 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 122706 472 5686 5685 5682 9861 9491 5684 5683 M PHASE%REACTOME%REACT_910.5 M Phase 91754 9133 6232 5861 8335 5862 8334 653604 8337 10783 2801 79648 81876 10592 2029 8331 10776 8615 255626 10051 4001 23047 5885 55746 9126 8358 333932 8352 8359 8353 8354 8338 8339 474382 8357 23244 8356 55844 8347 64689 8348 29781 54892 8345 26003 8346 23310 387893 8548 8340 8343 8344 8341 84930 8342 140609 3021 3020 85236 8968 8360 8362 8361 8364 54145 8363 8365 8366 5519 8970 8368 5518 8349 8367 5515 100616282 5516 10112 8351 23383 7175 9883 8350 10726 25836 8355 9493 5347 5529 3013 5528 3012 5527 5579 5525 723790 23122 126961 5526 8294 23332 23225 554313 121504 3015 3014 8370 3018 3017 57405 996 1058 80152 83540 7324 9184 991 699 23592 1062 5925 1063 1060 151648 9183 9232 348235 81565 25909 55166 3796 730268 57551 8379 128312 51433 79019 55920 11130 100527963 5048 22919 23421 11065 55143 55839 91687 23141 64105 81930 79172 29882 6249 9212 7443 8697 80776 29945 4085 84643 3619 9793 23165 51529 25936 401541 11243 100526739 147841 9700 23279 5520 151246 220134 79902 6396 701 10393 378708 255919 23399 23063 113130 129401 51434 55055 54821 54820 11004 9735 6418 79980 221496 79003 2010 64682 9688 5501 10735 79682 64946 54908 9663 10274 10403 332 8881 8290 9972 7514 5711 5710 5714 5713 5719 23198 5715 5716 5701 7311 5696 5687 5695 5700 5694 5717 5718 5688 5689 2491 57082 246184 5720 7316 10213 5698 983 5699 143471 5721 6233 5578 5905 8021 10197 5707 5706 5709 5708 5690 5705 5691 7321 5704 7314 5692 5693 5702 122706 11097 5686 5685 5594 5682 9861 9491 23511 5684 8243 8815 5683 23636 64900 10762 5903 26271 8480 891 23175 348995 9631 53371 4927 8086 1459 1457 64151 23397 1460 57122 9918 79023 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_150180.2 Assembly of collagen fibrils and other multimeric structures 1306 1301 85301 3655 4318 5339 50509 1300 1302 1295 4316 1296 1290 1292 1278 1277 5118 1281 1291 1280 4322 1288 80781 9313 255631 1289 1293 1520 1282 4314 1285 1284 7093 1514 1287 1515 1508 131873 1286 977 256076 3691 3918 4015 3914 4016 84171 4017 84695 7092 649 3909 1294 ADRENOCEPTORS%REACTOME%REACT_16927.1 Adrenoceptors 155 150 146 152 147 148 153 154 151 PLC BETA MEDIATED EVENTS%REACTOME%REACT_15426.2 PLC beta mediated events 801 805 156 808 1385 5330 5332 5582 5331 3708 3709 2779 107 108 109 2771 5153 2781 2770 112 115 114 111 5577 5137 113 346562 196883 2773 814 5576 5136 5573 5568 5567 5580 5566 5321 3710 5594 2780 2775 5575 23236 5578 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_150359.2 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 8471 1796 29904 6198 7248 51719 81617 101930123 6794 5565 5564 5563 5562 92335 5604 5571 5605 2549 5291 53358 25759 3569 3667 3570 3265 117145 54106 55437 6009 5290 51422 57521 53632 1978 8660 5781 1977 1975 7249 5289 6194 983 2475 30849 6464 5894 152831 2264 9965 7297 5140 7529 3845 64223 4893 26281 3479 101060747 3480 10818 3717 5296 1981 5170 3716 57761 6654 5295 5595 2247 2246 2249 2255 8823 27006 208 2251 2252 3481 2254 2248 8817 8074 5594 5494 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_115676.1 Antiviral mechanism by IFN-stimulated genes 7324 51191 26781 10762 6043 7311 619567 619568 5903 55746 7318 6772 100302143 8480 1974 5335 1973 1977 23586 100847079 7316 23165 3661 5300 23279 79902 7334 7706 6233 348995 9246 652965 652966 9631 9636 677847 53371 4927 5610 8086 8021 4599 129401 7175 9883 1981 3716 3434 5595 4734 5495 4600 3836 9688 7314 11274 23225 3837 3839 3838 3841 9972 3840 1982 11097 2317 57122 25820 373856 9775 9470 8672 23511 402569 317649 79023 23636 EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%REACT_228189.1 EPH-ephrin mediated repulsion of cells 55851 2051 160 2047 163 2049 2048 1947 161 4318 1949 284656 1948 7525 8218 83464 101927462 2534 1211 51107 7410 2041 1944 5879 2046 1945 2045 4067 7074 1969 1946 2044 1942 285220 2043 1759 2042 1943 10451 102 1173 4313 1175 5664 2050 1213 1212 23385 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME%REACT_17004.2 Chaperonin-mediated protein folding 60 8877 7411 10471 5202 26272 63971 10517 692201 26985 55294 100996906 54461 26224 22803 6499 26190 8237 26270 26234 84261 6950 347733 7280 83752 81027 10575 10376 10694 22948 10381 100302138 101927137 11328 10576 10564 100507577 7278 26792 84790 10574 6468 84617 10528 908 692213 7277 10383 10382 5204 5201 5203 677812 7203 113457 7846 TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME%REACT_75899.1 TWIK-releated acid-sensitive K+ channel (TASK) 51305 3777 SIGNALING BY PDGF%REACTOME%REACT_16888.4 Signaling by PDGF 6199 3815 2932 5581 23035 5582 572 5604 5605 2064 4690 1950 1026 5921 1398 3265 145957 6777 2931 1027 8503 1956 2309 5156 6778 8660 112 5335 115 114 7409 111 5137 113 2069 26523 80310 196883 5155 814 7249 1292 5580 983 2475 1291 1839 3932 23239 842 1147 50852 5578 5894 1293 801 253260 805 156 7297 808 1385 940 3084 685 942 941 3708 3709 3845 84335 64223 4893 101060747 26281 3717 10818 4193 9542 930 5170 5159 57761 23112 5153 5154 10718 5595 6696 2247 2246 2249 2255 8823 27006 2251 2252 2254 2248 8817 8074 5327 5340 5594 2889 1399 8440 9564 5045 2549 7058 5291 5293 27161 3569 3667 2534 7057 5728 3570 117145 79109 5290 4343 6772 6774 5781 5577 5136 5576 5573 5568 5567 3164 5566 3710 5575 152831 2264 1282 9965 1298 1285 1284 57690 1297 1287 7059 7529 7060 131873 107 5296 1299 108 1286 192669 109 3716 6776 256076 6654 5295 10000 192670 207 208 2308 27327 2886 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_21387.1 Energy dependent regulation of mTOR by LKB1-AMPK 7248 51719 81617 6794 5565 5564 5563 5562 92335 5571 7249 55437 5494 6009 51422 57521 53632 TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME%REACT_6822.6 Transfer of LPS from LBP carrier to CD14 929 3929 ANDROGEN BIOSYNTHESIS%REACTOME%REACT_11059.3 Androgen biosynthesis 1081 1586 51144 6716 6715 79644 3283 3972 3284 5443 3293 CARBOHYDRATE METABOLISM%REACTOME%REACT_474.7 Carbohydrate metabolism 10331 3099 3098 126792 3073 3074 55746 2538 2539 3038 9394 8972 3037 3036 2720 11181 2719 727936 4958 3425 1634 3423 9348 63827 8908 5519 5518 6527 5515 5516 8509 8702 7175 9883 8704 8703 9331 9334 4969 6515 2997 5528 6513 2998 10057 29940 2990 64579 2817 2132 2131 5106 5105 23225 960 55454 6888 7360 6476 10082 6482 6483 6487 6484 55276 1836 2992 2023 135152 51363 5223 5224 5226 2203 10894 5230 200010 55576 8402 6448 8789 23165 337876 23279 90161 79902 26330 22934 64711 375790 5549 1463 129401 4669 51000 8534 50515 7957 4060 5507 9060 9688 55790 7086 2683 9972 92126 55501 9061 54480 3938 23563 8604 2239 221823 3373 79586 2646 9469 3339 7311 9653 3340 92579 4191 6383 11285 4190 10165 10678 9435 378884 10675 3795 2632 283464 8372 100616124 7316 6120 9957 11041 9956 9955 633 2806 2805 11046 6233 79369 801 27087 805 5255 808 5256 347734 5257 11081 5214 229 226 411 176 178 6382 643853 5236 648740 6385 8021 26035 10855 2821 10861 2262 3101 60495 7314 5213 5210 11097 5208 5207 6518 23511 5211 23636 5209 25796 6548 277 278 56548 276 2542 266722 10762 10402 280 22856 221914 5903 222537 93010 5837 5834 10090 279 5836 8480 6576 6517 5260 2799 57818 8692 5568 5567 6523 5566 6526 6524 26229 5261 230 5091 348995 5634 7167 166012 9631 11261 3161 113189 53371 2027 2026 9951 9953 4927 9672 2597 8086 2331 2584 2582 6514 1464 2592 5631 1462 1468 2645 4166 57122 79411 79023 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME%REACT_702.4 Recognition and association of DNA glycosylase with site containing an affected pyrimidine 4913 8930 10309 23583 6996 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_1993.3 Repair synthesis for gap-filling by DNA polymerase in TC-NER 5111 5982 5981 5427 5983 6119 6118 57804 6117 5426 5425 5424 10714 5985 5984 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_163646.3 SUMO is transferred from E1 to E2 (UBE2I, UBC9) 7341 10054 6613 6612 10055 101929087 7329 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME%REACT_70.3 Removal of the Flap Intermediate 5422 5111 2237 23649 5557 6119 6118 57804 6117 5558 5425 5424 10714 1763 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_23837.2 Interleukin-3, 5 and GM-CSF signaling 3568 3558 3567 1438 3559 3560 1439 7006 29760 7525 5291 5293 1398 6850 2534 7534 3717 5296 3561 3562 3563 3265 1437 6777 3716 4067 6776 5290 6654 3718 8503 5295 5781 3055 7409 867 9846 5777 5568 5567 5566 2889 1399 3635 6464 3636 SIGNALING BY NODAL%REACTOME%REACT_111057.1 Signaling by NODAL 2657 2309 130399 91 7044 10637 5046 5045 100507472 4088 6997 4089 55997 4838 10589 93 92 8928 4087 9350 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200827.2 SIRT1 negatively regulates rRNA Expression 8335 8334 653604 8337 8331 255626 128312 8358 333932 8352 8359 9013 8353 8354 9014 8338 8339 677805 474382 23378 8357 8356 8347 23411 8348 8345 8346 6908 8340 79101 8343 8344 8341 8342 6839 3021 3020 692063 85236 8968 8360 8362 8361 100302240 8364 54145 8363 8365 8366 8970 8368 8349 8367 100616282 8351 654320 8350 9015 8355 3013 3012 692072 677822 723790 126961 8294 677792 554313 121504 3015 3014 8370 3018 3017 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_12564.4 AKT phosphorylates targets in the cytosol 10000 207 2932 208 572 7249 84335 1026 4193 842 2931 1147 1027 SHC1 EVENTS IN EGFR SIGNALING%REACTOME%REACT_12579.2 SHC1 events in EGFR signaling 7297 5781 5604 5605 7529 3845 1950 983 3569 4893 3717 3265 3570 5594 3716 6464 6654 1956 5595 5894 CREATION OF C4 AND C2 ACTIVATORS%REACTOME%REACT_8012.5 Creation of C4 and C2 activators 2219 101930374 8547 3539 5648 4153 2220 28916 28442 100423062 28454 3542 28912 3514 28776 3502 713 3503 715 712 28876 3501 716 28874 714 28908 28299 28896 1401 28834 3538 440786 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_118780.2 NOTCH1 Intracellular Domain Regulates Transcription 3066 51564 4609 79885 3065 3280 1024 6907 7089 7088 6500 23462 3091 2033 7311 2648 55869 55534 10014 892 8841 3516 8454 388585 83933 9734 1387 9794 26508 10013 84441 7314 9612 23493 4851 9611 7316 8850 22938 9759 79718 9978 10046 7091 6233 ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_701.4 Activation of BID and translocation to mitochondria 841 637 3002 4836 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_169316.2 Defective MMAA causes methylmalonic aciduria type cblA 55191 4552 1719 4548 32 4594 31 23475 9446 5743 5646 8029 5645 55229 5644 25974 55312 81034 316 53354 55163 8034 6947 10560 55034 81693 9962 3141 9963 56922 60496 60490 27010 8566 166785 23057 5095 326625 5096 101929880 440387 101928493 6948 6470 1504 51293 349565 80025 64087 4338 27249 4524 54 6573 51248 113278 80347 101928717 2694 5091 4522 119391 113235 27304 65220 80704 79178 200895 6515 6513 93100 5167 55788 8884 80308 5740 1528 79717 4363 1582 2194 1727 10135 686 64802 10243 79646 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_1892.2 Elongation arrest and recovery 1025 5438 100126332 5439 5436 5437 5434 5435 8178 5431 5433 904 5430 905 5432 6749 2962 7469 5440 2963 100302242 6829 25920 5441 11198 6827 7936 9150 6921 6924 6923 6917 51497 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME%REACT_18274.2 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 3790 2785 2786 51764 2783 2784 2787 10411 2740 2788 2791 2641 3747 3745 3708 3709 55970 2778 54331 10681 2793 2792 2790 9495 112 59345 114 8826 2782 94235 111 5577 5906 5576 11069 5573 5568 5567 5566 26251 3710 5575 IMMUNE SYSTEM%REACTOME%REACT_6900.8 Immune System 1398 7410 54106 7409 29127 2219 8547 5648 2220 816 817 818 815 1211 10112 9493 8915 84433 8517 10125 5579 5495 23291 5966 1154 6195 6197 6196 3839 10892 3838 3841 3840 1982 2317 25820 5970 4794 373856 4792 9470 8672 4793 4790 402569 3606 25780 317649 6885 3551 8835 996 7324 991 1062 3796 730268 51433 11065 81930 29882 8697 29945 84643 51529 5627 6396 10393 51626 84516 10120 3812 3802 80329 4277 100653050 3821 3811 4345 10225 1075 10219 114876 644076 101929809 79465 7879 56253 83547 79659 100507436 10288 51434 11126 11024 1780 11004 131450 11025 1783 10671 1510 1519 11006 64682 1512 8722 4644 959 975 10666 972 8881 3108 3109 3112 140735 3111 10859 925 10870 3799 2213 135250 51164 727787 10990 3798 5476 6199 9402 3815 3813 57292 23601 400709 7305 5581 23035 5582 572 5604 3810 5605 2064 3805 9040 1950 3808 1026 3804 6850 3806 3803 100049587 3265 5879 145957 2931 1027 1956 3809 2309 3797 5156 3937 8660 22920 22914 5335 54209 3832 3320 5336 3835 100132285 100500810 3831 10326 9371 5137 2069 695 3133 11127 5155 814 3824 285643 3822 26153 7249 56992 342510 983 2475 3107 3106 89953 1839 3932 284266 23239 842 1147 50852 5894 253260 973 974 156 640 7297 100528032 27071 100133046 6725 940 3084 685 942 941 118788 7220 3507 7295 29760 821 3495 868 9902 100996743 4360 3845 50489 84335 9436 64223 4893 101060747 3717 4193 9542 3105 930 5170 5159 57761 100132417 10718 101928757 54210 9208 8398 2547 57154 51128 100996919 10451 5724 5906 30011 55824 2033 4650 6402 5610 101927462 9871 5617 4775 6654 4773 4772 3836 998 3837 120425 1525 23220 5609 5817 5819 54778 10193 999 9844 3055 9846 5908 4684 83737 677847 10273 8907 8905 7175 1981 5600 7408 3688 8065 8452 10053 23225 960 3572 9021 1445 3568 3558 3567 160 1438 3559 3560 164 10411 1439 163 162 161 3562 3563 1437 9261 6772 661 6774 1974 1973 1977 1174 5788 1173 1175 375 3164 6456 23279 10802 79902 10427 6464 7520 130340 6416 5534 101060521 4734 64837 5530 5532 147700 9688 24137 11069 6921 9972 6923 10484 5641 5711 5710 5714 5713 5719 8945 2932 122618 23198 6500 5715 5716 1499 5701 7311 5696 9632 5687 5695 5700 5588 5694 1785 5717 5718 5688 5689 8454 5720 7316 10213 5698 9978 5699 143471 5721 6233 801 805 808 1385 26281 10818 2247 2246 10197 2249 5707 2255 5706 8823 5709 27006 5708 5690 2251 5705 2252 5691 867 5704 2254 2185 7314 2248 5692 8817 5693 8074 5702 51447 6712 122706 5686 5685 5682 1509 5594 9861 9491 5684 5683 6868 926 920 5094 3685 5577 5576 5573 5568 5567 5566 5575 652965 23480 652966 57690 103 51728 57122 3635 3636 4651 101930374 5603 10235 4627 4620 4153 115727 28442 403339 245908 5062 245909 9666 28454 3093 9520 729230 401036 8139 4641 6043 5027 51444 10006 6049 1378 25847 26232 10910 117285 255488 27252 10458 55746 6047 4064 644414 136371 5071 3561 3502 3574 3503 26118 414325 3082 89910 23608 728358 6777 55894 51465 90678 3958 79654 8503 3501 9817 64170 51343 142689 26052 11059 9690 598 197131 400830 55718 55284 596 142685 22861 6502 142686 64145 114548 55585 642 23586 26999 7704 51517 151636 127544 84513 9039 9533 28908 6300 997 26273 7100 55070 64135 10810 4012 101929832 245929 122769 245927 7128 9903 92591 245928 1235 126433 55703 503614 10425 503618 80176 64320 55593 26259 1650 245915 4591 5589 115290 245911 54926 1660 245913 22888 7706 3693 245910 51311 10533 503841 51619 147179 245939 245940 57506 504180 245930 7006 7412 245934 3695 245932 245937 245936 100289462 245938 3383 3676 9883 3384 3385 23112 3386 3683 5595 51082 5440 25 5441 8887 2210 3459 3460 2207 2209 63916 28834 613209 84282 2205 2889 1399 2206 735 8554 3458 613211 26007 196051 2212 731 730 2214 10628 613210 3497 8411 28916 51191 10878 417 733 732 829 28912 1535 58484 721 629 1536 720 5437 727 5434 729 5435 653361 722 725 713 718 715 712 7318 140881 4689 716 717 4688 23646 830 837 140596 7448 140850 7456 714 51284 29108 100133267 1604 100847079 28299 966 834 645832 7294 10152 84166 10787 23165 7462 1401 5300 9474 3538 9140 9450 728489 3684 10695 3004 9246 1520 100302652 100129216 23352 3539 5337 9320 10163 140739 9636 80196 5338 81622 9730 9447 79876 81623 55182 8924 8936 100423062 63891 1793 27338 1514 63893 64219 1513 3542 23304 84727 3689 9051 9354 7529 644150 148581 114088 1515 1508 7317 3514 65264 79132 10075 4179 7319 3426 7325 55176 3326 7320 7534 28776 25898 54941 51676 129401 3442 101929047 28876 51130 3440 79754 3441 101930157 1670 51665 51666 1671 9867 28874 1387 10477 1667 80143 140462 3439 7337 3451 7326 1759 81559 7174 1668 1669 7327 3443 7332 55521 3444 24145 7328 3452 118424 93611 3448 3449 127247 23295 3445 221687 3446 90293 28896 81793 27327 100293534 3660 3075 140456 3659 140459 1540 92369 3456 140458 84676 79671 10489 1673 1672 10616 1675 55236 4210 140461 3929 55958 55845 140460 92912 440786 330 148022 7322 329 10010 26781 11035 7187 9641 100302736 84265 147945 64750 51428 6778 6737 115004 81844 171568 22954 81030 3428 340061 11277 26523 5591 84126 170506 7850 3665 3554 4215 3557 5580 54472 3661 353376 3553 29110 7098 8878 3552 1326 79155 5578 27297 4599 6773 3433 3434 8638 10581 3437 1443 3135 1444 10379 3394 4938 4939 2690 4600 2689 3662 2688 8519 1958 54739 3454 10623 3134 10621 6041 10622 11274 4940 10410 3430 3429 2634 2537 5770 11097 3663 3669 3664 23511 5618 1442 619567 619568 5903 7341 2923 23327 9631 22872 6891 6890 64167 6892 51752 7428 8453 7186 8772 8737 841 843 4361 5909 23108 6494 1493 151888 6786 9020 8764 2268 5133 23308 80380 3708 3709 29126 1432 5519 5518 5515 5516 84876 5153 5529 5528 5527 5525 5526 2549 100653194 5291 5293 567 3569 3667 2534 5728 3570 117145 553128 79109 5290 4343 124599 5781 5136 5777 3710 107 108 109 1072 3115 115361 6672 100509457 3117 3984 28577 60 3119 3118 916 915 10437 3702 5063 388646 4261 7454 4502 27040 100507709 163351 2633 5747 55740 2635 3113 8976 115362 51466 4690 3122 7525 5058 10093 10092 10552 10097 917 10096 100996809 100507714 10094 71 101060835 3120 10109 2533 4067 3123 28639 3656 23118 51295 7336 1845 112 1848 115 3654 114 1849 7099 466 11213 111 1846 113 246184 2353 7097 10454 196883 100996792 26272 929 7535 246330 64127 5608 7867 28755 55294 3125 6285 4791 3126 3127 5598 177 8651 5599 114609 7334 26270 7335 6283 7189 1781 1778 10121 8021 8655 7323 10540 7321 11258 23636 5646 5645 10762 27161 10952 100302143 8480 948 6288 9820 5289 30849 1639 348995 5606 152831 835 9252 2264 9965 4214 23643 7184 10333 5601 57161 5602 10392 53371 1386 51135 57162 3309 3146 100500842 2002 4927 8767 4615 257397 3725 811 59307 4205 351 4208 8086 5296 3575 192669 3716 29927 6776 3718 5295 10000 192670 207 208 2308 11128 9775 5371 79023 SYNDECAN INTERACTIONS%REACTOME%REACT_163942.2 Syndecan interactions 3691 2247 100500840 3371 7448 3655 3688 7040 645832 9672 6382 6385 3690 87 3685 7057 3673 51399 6383 3693 5578 8573 VPU MEDIATED DEGRADATION OF CD4%REACTOME%REACT_9031.1 Vpu mediated degradation of CD4 5711 5710 5714 5713 5719 8945 23198 6500 5715 5716 5701 7311 5696 5687 5695 920 5700 5694 5717 5718 5688 5689 5720 7316 10213 5698 5699 143471 5721 6233 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 5684 5683 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_169149.2 Defective MTR causes methylmalonic aciduria and homocystinuria type cblG 55191 4552 1719 4548 32 4594 31 23475 9446 5743 5646 8029 5645 55229 5644 25974 55312 81034 316 53354 55163 8034 6947 10560 55034 81693 9962 3141 9963 56922 60496 60490 27010 8566 166785 23057 5095 326625 5096 101929880 440387 101928493 6948 6470 1504 51293 349565 80025 64087 4338 27249 4524 54 6573 51248 113278 80347 101928717 2694 5091 4522 119391 113235 27304 65220 80704 79178 200895 6515 6513 93100 5167 55788 8884 80308 5740 1528 79717 4363 1582 2194 1727 10135 686 64802 10243 79646 AXON GUIDANCE%REACTOME%REACT_18266.1 Axon guidance 4651 391 4627 5062 4756 80728 9901 7410 7074 7204 26052 4629 1942 285220 4628 2043 2042 1943 8874 3791 22885 3983 84448 25791 6092 1213 1212 1292 7223 1291 784 7224 5216 4684 785 782 64096 783 1293 5364 5786 284656 6461 56924 103910 5217 79784 10398 1211 57113 4637 2041 1944 2046 1945 9423 2045 1969 1946 2044 5595 6237 7408 1741 6091 1742 1630 9353 3688 10486 6195 2817 57144 25 10298 6197 10487 23122 6196 7225 23332 7222 27 9723 4233 8482 5365 80031 23129 57556 10507 64218 10154 971 1739 160 163 8440 161 9037 3569 3786 8218 2534 3785 3570 5781 1173 5788 101928143 1175 137970 8633 285704 6456 6478 148738 56963 116986 27330 6586 6585 6477 776 1282 100132336 6900 1298 1285 375790 1284 9048 4902 8128 1793 1297 7903 1287 2674 7529 2675 2668 8911 8912 8913 131873 3326 1299 1463 1286 775 101930388 5623 5621 256076 779 1759 24137 23385 1072 2051 3984 3985 60 2047 9475 2932 7305 2049 6093 2048 5063 1947 2902 2904 5604 55740 5747 8976 5605 55558 1949 2064 51466 1948 8829 1809 4690 7525 10371 10570 91584 5058 1808 5921 2242 1400 1020 10093 5362 56896 10092 5361 5588 10552 10097 1785 6383 10096 3265 5879 10094 71 10109 4067 1956 64283 8851 5335 54209 3320 4313 285643 983 5894 7297 1385 59277 7220 3845 9855 27289 4893 3717 6327 6329 8506 6709 6708 27255 6710 6712 3672 3673 6334 6332 6331 5594 6711 6328 4478 6326 6335 8986 55800 10048 85390 8515 57731 10752 8828 51332 6386 7430 6324 6323 4318 23114 5962 100133941 1641 3912 214 3897 8650 57698 3678 3690 83464 85389 3685 3915 51107 288 286 287 3674 284217 1272 3680 4897 8997 10451 102 5664 7094 55851 9252 388 387 23396 389 23365 6453 5880 10627 28964 2909 90249 219699 101927462 57522 3312 1459 1457 3716 6654 5306 998 1460 2050 23380 6655 9826 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_1064.4 Displacement of DNA glycosylase by APE1 4913 4968 8930 10309 4350 23583 328 6996 4595 SIGNALING BY INTERLEUKINS%REACTOME%REACT_22232.2 Signaling by Interleukins 8945 6500 5604 5605 7525 1398 6850 3561 3265 3574 3082 6777 4067 8454 8503 3656 23118 7336 3055 3654 7409 11213 9846 10454 7850 246330 3554 64127 4215 5608 3557 54472 983 9978 4791 3553 8878 3932 7334 3552 7335 1326 1147 7189 79155 5894 7297 7006 29760 3845 4893 3717 5595 8517 867 2185 3572 9021 5970 2889 5594 1399 4790 3606 6885 3551 3568 3558 3567 1438 3559 3560 1439 5291 5293 3569 2534 3562 3563 3570 1437 5290 6774 5781 834 5777 5568 5567 5566 6464 57161 10392 51135 57162 8767 7529 4615 257397 6416 7534 5296 3575 3716 6776 3718 6654 5295 3635 3636 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_330.2 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 10018 598 27113 5366 596 637 100422899 100422832 90427 572 HEME BIOSYNTHESIS%REACTOME%REACT_9465.4 Heme biosynthesis 5498 7390 211 210 1371 2235 212 7389 3145 1352 1355 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_22230.4 Synthesis of Dolichyl-phosphate 4597 79644 57171 79947 22845 STABILIZATION OF P53%REACTOME%REACT_309.2 Stabilization of p53 5711 5710 5714 5713 5719 23198 5715 5716 5701 7311 5696 5687 5695 5700 5694 5717 5718 5688 5689 5720 64326 7316 10213 5698 5699 143471 5721 6233 7157 4193 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 122706 472 5686 5685 5682 9861 9491 5684 5683 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_147797.3 Regulation of cholesterol biosynthesis by SREBP (SREBF) 5465 32 31 6907 6721 7108 22937 3157 9632 6309 5469 23054 79071 51128 4598 5901 2222 2224 3422 4597 10802 6256 10427 10654 6604 57678 8648 96764 4047 4801 8720 4802 4800 51141 9453 6667 9871 51360 1595 1717 80205 1387 6713 2194 3837 10498 85441 79718 3638 10484 10499 APC TRUNCATION MUTANTS ARE NOT K63 POLYUBIQUITINATED%REACTOME%REACT_228143.1 APC truncation mutants are not K63 polyubiquitinated 5711 5710 5714 5713 1452 5719 3065 8945 2932 7089 23198 139285 7088 6500 5715 5716 1499 5701 7311 5696 5687 5695 5700 166 5694 6932 6934 5717 5718 5688 5689 8454 8312 5720 7316 10213 324 5698 83439 9978 5699 7090 7091 10023 143471 5721 6233 5519 5518 5515 5516 5529 1487 5528 1488 5527 23401 10197 5707 5525 5706 5709 5708 5690 5705 5691 5704 5526 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 51176 5684 5683 ORGANIC ANION TRANSPORT%REACTOME%REACT_22310.1 Organic anion transport 116085 10864 9356 9376 55867 TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME%REACT_16881.2 Transmission across Electrical Synapses 10052 56666 24145 84694 57369 ALPHA-DEFENSINS%REACTOME%REACT_115574.1 Alpha-defensins 1667 920 1668 1669 5646 728358 417 5645 1670 1671 AUTOINTEGRATION RESULTS IN VIRAL DNA CIRCLES%REACTOME%REACT_6866.6 Autointegration results in viral DNA circles 3159 11168 8815 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_200668.2 WNT mediated activation of DVL 1857 1856 1454 1459 8395 1457 1460 1855 CELL-CELL JUNCTION ORGANIZATION%REACTOME%REACT_19331.2 Cell-cell junction organization 1012 137075 10686 1013 1016 5817 5819 56288 9080 1015 23562 5818 999 10207 1003 1001 1002 1004 50855 1005 1007 1008 9071 9073 1006 9074 3728 1009 9075 57863 64398 9076 7122 50848 1010 5584 23705 9069 149461 49861 92359 24146 64403 53842 1495 1000 51208 25945 84552 26285 84612 5010 1500 253559 1366 1365 1364 81607 RAF ACTIVATION%REACTOME%REACT_2077.4 RAF activation 3845 4893 3265 5894 7529 RELEASE%REACTOME%REACT_6326.3 Release G-PROTEIN ACTIVATION%REACTOME%REACT_15457.1 G-protein activation 2785 2786 51764 2783 2784 2787 2788 2791 5443 2779 55970 54331 2793 10681 2771 2792 2781 2790 2770 59345 2782 94235 346562 5173 2773 2780 4988 2775 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_13776.1 p75 NTR receptor-mediated signalling 3066 393 6868 3065 10276 572 4803 6610 7311 83464 51107 7410 89846 5879 23263 7074 7204 23421 8997 1894 26230 11214 29 3654 11108 8874 57449 7409 10451 64857 25791 23229 5664 7316 57142 9138 8878 100505585 101927057 5599 6233 7189 2245 835 55851 221472 27018 4804 387 9459 7531 27237 836 23365 6453 8767 4615 9500 5584 5924 8841 4168 6654 396 9181 7314 121512 10018 9828 26574 101930241 50649 6655 4974 5970 84033 9826 4099 23370 4792 50650 84894 4790 23385 3551 TRIGLYCERIDE BIOSYNTHESIS%REACTOME%REACT_1190.3 Triglyceride Biosynthesis 23305 64900 9524 57678 51703 79993 2819 31 2712 253558 2710 8694 51144 54898 64834 150763 137964 84649 79071 47 79888 6576 6785 56894 56895 84803 2194 9663 10554 10555 3293 23175 23171 2182 55326 2181 253017 2180 83401 254531 60481 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_118744.2 Pre-NOTCH Expression and Processing 10959 6400 5986 595 56983 4242 23509 57690 5870 5045 3955 10402 2033 150786 7157 1869 3725 2648 27161 55534 192669 1871 3516 23112 4343 1387 4853 4854 4855 192670 9794 7029 487 84441 26523 4851 2683 27327 8850 22938 10046 6487 7027 6484 489 488 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME%REACT_16973.1 Orexin and neuropeptides FF and QRFP bind to their respective receptors 347148 3061 3062 64106 10886 84109 3060 8620 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_1280.3 Response to elevated platelet cytosolic Ca2+ 1072 7423 5582 2277 7040 7414 7424 1950 2335 3690 7057 27154 3082 5660 3674 2621 2243 948 2162 335 2 710 6678 5155 7043 213 3827 7042 2266 2153 2244 5175 5216 5473 101060363 7094 5627 2157 5196 5578 801 5478 805 808 88 6810 226 7450 3309 351 87 3479 5054 7277 10257 440915 7273 7076 7422 6403 5552 5265 928 81 3920 5579 7018 1191 3273 813 7044 10487 10637 3481 29106 22927 6647 967 9948 5340 2316 5341 22915 6814 7114 5345 1675 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME%REACT_1096.3 Processing of Intronless Pre-mRNAs 100302196 53981 8106 22916 51692 4686 10914 79869 1477 1478 29894 10978 51585 11051 100126351 1479 REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME%REACT_25302.1 Reactions specific to the complex N-glycan synthesis pathway 4247 4122 4124 2530 NEF-MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS%REACTOME%REACT_11149.2 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 160 940 100996919 164 163 100500810 1174 162 1173 10053 51606 130340 161 1175 926 375 8907 8905 567 920 101927462 3105 3932 55690 FASL CD95L SIGNALING%REACTOME%REACT_900.3 FasL CD95L signaling 841 843 355 8772 356 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_160214.2 Signaling by NOTCH1 in Cancer 3066 3714 6868 3065 3280 6907 54492 1024 7089 408 409 7088 23462 6500 3091 7311 2648 8650 83464 113878 10014 51107 1272 8454 9794 26508 10013 102 84441 101928143 23493 4851 8788 5664 7316 142678 22938 9759 9978 10046 7091 54567 57534 83737 6233 51564 55851 79885 4609 9148 2033 55869 55534 182 892 8841 101930388 3516 28514 388585 83933 9734 1387 7314 9612 9611 92737 1840 8850 79718 23220 23385 INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME%REACT_25367.2 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate 728294 79944 137872 T41 MUTANTS OF BETA-CATENIN AREN'T PHOSPHORYLATED%REACTOME%REACT_228261.1 T41 mutants of beta-catenin aren't phosphorylated 5711 5710 5714 5713 1452 5719 3065 8945 2932 7089 23198 139285 7088 6500 5715 5716 1499 5701 7311 5696 5687 5695 5700 166 5694 6932 6934 5717 5718 5688 5689 8454 8312 5720 7316 10213 324 5698 83439 9978 5699 7090 7091 10023 143471 5721 6233 5519 5518 5515 5516 5529 1487 5528 1488 5527 23401 10197 5707 5525 5706 5709 5708 5690 5705 5691 5704 5526 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 51176 5684 5683 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME%REACT_11238.3 Metabolism of water-soluble vitamins and cofactors 55191 4552 1719 4548 32 4594 31 23475 9446 5743 5646 8029 5645 55229 5644 25974 55312 81034 316 53354 55163 8034 6947 10560 55034 81693 9962 3141 9963 56922 60496 60490 27010 8566 166785 23057 5095 326625 5096 101929880 440387 101928493 6948 6470 1504 51293 349565 80025 64087 4338 27249 4524 54 6573 51248 113278 80347 101928717 2694 5091 4522 119391 113235 27304 65220 80704 79178 200895 6515 6513 93100 5167 55788 8884 80308 5740 1528 79717 4363 1582 2194 1727 10135 686 64802 10243 79646 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_13541.1 Caspase-mediated cleavage of cytoskeletal proteins 840 6709 28988 841 118 4137 836 2934 7431 839 5339 2620 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME%REACT_821.2 Cyclin D associated events in G1 1030 595 1875 1874 1022 1019 5925 6500 902 7311 1869 5519 1026 5518 5515 5516 1163 1021 1871 1870 1027 8454 1029 1031 6502 7029 28227 1032 7314 5934 4331 896 7316 894 5933 7027 5520 6233 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_75842.1 Antigen processing: Ubiquitination & Proteasome degradation 9666 9520 3093 401036 8139 54778 51444 6049 25847 26232 255488 27252 6047 136371 10193 5071 26118 89910 23608 51465 90678 79654 9817 51343 11059 142689 9690 197131 55284 142685 142686 6502 55585 642 7704 151636 127544 9039 997 26273 55070 4012 101929832 122769 9903 92591 126433 10425 80176 64320 26259 4591 115290 54926 22888 10533 51619 83737 10273 23291 8065 8452 9021 996 7324 991 730268 51433 7318 11065 29882 100847079 8697 29945 51529 10393 9246 100302652 23352 9320 140739 80196 9730 79876 55182 8924 63891 27338 63893 64219 23304 84727 9354 148581 114088 7317 65264 10075 7319 7325 7320 25898 51676 101929047 51130 79754 101930157 51665 4734 51666 9867 51434 10477 140462 7337 7326 81559 7174 7327 7332 55521 64682 7328 118424 93611 127247 23295 221687 90293 8881 6921 140456 140459 6923 92369 140458 84676 10489 10616 55236 140461 55958 140460 92912 5711 5710 5714 5713 5719 8945 7322 23198 6500 5715 5716 5701 9040 7311 5696 5687 5695 5700 5694 5717 5718 5688 5689 8454 64750 7336 6737 22954 246184 5720 26272 7316 10213 5698 55294 9978 5699 8651 7334 7335 143471 26270 5721 6233 868 7323 10197 5707 5706 5709 5708 5690 5705 7321 5691 5704 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 5684 5683 57154 9820 23327 7428 8453 ENOS ACTIVATION%REACTOME%REACT_12477.3 eNOS activation 801 805 857 808 4846 207 3320 10434 340481 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_833.3 RNA Polymerase II Transcription Elongation 728340 1022 2968 2967 1025 5438 100126332 5439 5436 902 5437 5434 5435 8178 5431 5433 904 5430 905 5432 22916 2962 6749 2963 7469 5440 6829 100302242 25920 5441 11198 4331 4686 6827 7936 2068 9150 2071 6921 6924 6917 6923 2965 51497 2966 G1 PHASE%REACTOME%REACT_1590.1 G1 Phase 1030 595 1875 1874 1022 1019 5925 6500 902 7311 1869 5519 1026 5518 5515 5516 1163 1021 1871 1870 1027 8454 1029 1031 6502 7029 28227 1032 7314 5934 4331 896 7316 894 5933 7027 5520 6233 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME%REACT_21330.2 Synthesis and interconversion of nucleotide di- and triphosphates 6241 6240 7296 1503 7295 203 204 26289 4830 4831 1841 2987 51727 654364 50484 4833 2745 56474 AMINE LIGAND-BINDING RECEPTORS%REACTOME%REACT_16983.1 Amine ligand-binding receptors 1133 3354 3358 59340 3357 3350 3274 3360 11255 3269 3361 3362 3363 3352 3356 3351 3355 1132 83551 1129 9038 150 152 1128 1131 134860 319100 134864 155 9288 146 147 148 9287 153 154 1815 1816 1813 1814 151 1812 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME%REACT_27161.2 Transcriptional regulation of white adipocyte differentiation 5465 1019 6907 1024 3952 6721 7040 7480 100996782 5469 55588 5468 219541 23054 51003 9477 948 51129 6517 10001 84246 29079 23097 6256 1879 1050 6604 101928625 7026 8648 96764 9370 23389 688 81857 9282 112950 4023 1959 1052 2033 54797 5346 892 8841 10025 9968 80205 1051 9969 1387 9412 6837 55090 9314 9439 400569 10891 7471 9862 90390 2167 5105 9612 9611 896 10498 9443 85441 9441 9442 8202 79718 7124 5970 9440 4790 51586 10499 REGULATION OF INSULIN SECRETION%REACTOME%REACT_18325.5 Regulation of insulin secretion 3790 6616 10411 9630 777 773 3630 9254 292 2864 291 9495 112 114 59345 8826 94235 5577 111 293 5906 5576 5573 5568 5567 5566 26251 3710 784 2776 5575 783 23236 5578 776 2785 2786 51764 2783 6861 2784 2787 5330 2740 2788 2791 4082 2641 3747 5331 3745 3708 100507353 3709 55970 2767 2769 2778 54331 10681 2793 775 2771 2792 2790 2770 150 6513 152 6833 2782 6514 1131 6812 3767 11069 6844 6804 SMOOTH MUSCLE CONTRACTION%REACTOME%REACT_20558.2 Smooth Muscle Contraction 4629 801 805 808 7168 7169 10580 800 72 140465 10174 59 4638 7414 25802 7171 7170 103910 3672 10398 4637 7094 3693 5829 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_1059.5 Extrinsic Pathway for Apoptosis 8717 6868 7132 355 7186 8772 8837 356 8737 8795 841 843 8743 7124 SIGNALING BY FGFR%REACTOME%REACT_9470.8 Signaling by FGFR 6199 3815 2932 5581 23035 5582 572 5604 5605 2064 1950 7311 1026 3265 145957 2931 1027 8503 1956 2309 5156 8660 112 5335 115 114 7409 5137 111 2069 113 26523 196883 5155 814 7316 7249 5580 983 2475 1839 3932 23239 842 1147 50852 6233 5894 5578 253260 801 156 805 7297 808 1385 940 3084 685 942 941 3708 3709 3845 84335 5518 64223 5515 4893 5516 26281 101060747 3717 10818 4193 9542 930 5170 5159 5153 23112 57761 10718 5595 10253 2247 2246 2249 2255 8823 673 27006 2251 2252 867 2254 7314 2248 8817 8569 8074 5594 2549 5291 5293 27161 3569 3667 2534 5728 3570 117145 79109 5290 4343 10817 5781 5577 5576 5136 5573 5568 5567 3164 5566 3710 5575 152831 2264 9965 57690 7529 107 5296 108 192669 109 3716 6654 5295 10000 192670 207 208 2308 27327 PYROPHOSPHATE HYDROLYSIS%REACTOME%REACT_21259.1 Pyrophosphate hydrolysis 27068 5464 ER-PHAGOSOME PATHWAY%REACTOME%REACT_111178.1 ER-Phagosome pathway 5711 5710 5714 5713 5719 23198 5715 5716 5701 7311 5696 5687 567 5695 5700 10952 5694 5717 5718 5688 5689 3133 5720 7316 10213 5698 3107 5699 3106 2923 143471 5721 6233 23480 6891 811 6890 55176 6892 3105 29927 3135 10197 5707 5706 5709 5708 5690 5705 5691 5704 3134 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 5684 5683 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_160255.4 Nuclear Envelope Breakdown 91754 9133 64900 9631 10783 255919 53371 23592 23399 10762 4927 4001 5903 8086 8021 55746 129401 7175 9883 5347 8480 5579 891 221496 2010 9688 7443 9663 23225 23175 23165 9972 983 11097 57122 23279 79902 23511 79023 8815 5578 140609 23636 348995 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_121036.2 The activation of arylsulfatases 153642 22901 25870 340075 411 347527 79642 416 415 410 414 412 285362 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_25148.5 Activation of IRF3 IRF7 mediated by TBK1 IKK epsilon 23643 5781 7099 148022 10010 7314 7187 9641 100302736 3665 929 7316 7311 3661 353376 29110 7098 6233 KETONE BODY METABOLISM%REACTOME%REACT_1861.4 Ketone body metabolism 3155 38 3158 622 5019 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%REACT_1022.2 Nonhomologous End-joining (NHEJ) 55775 3981 7520 2547 7518 5591 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_11152.3 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 28577 916 915 7305 28442 5817 5819 28454 3810 3805 3808 3804 3806 999 3803 917 28639 3809 22914 100132285 28908 3133 3824 28755 3107 3106 100528032 100133046 7412 3695 100996743 3383 3676 3105 930 3384 3385 3386 3683 3135 3688 8519 3134 28834 2214 28916 28912 926 567 718 100996919 28299 3538 3539 100423062 3812 3542 3802 3689 80329 6402 4277 100653050 3821 3811 3514 4345 10225 10219 644076 28776 101929809 79465 28876 56253 100507436 10288 28874 11126 11024 131450 11025 11006 959 975 10666 28896 120425 1525 10859 925 10870 2213 135250 727787 10990 440786 AXONAL GROWTH STIMULATION%REACTOME%REACT_13779.1 Axonal growth stimulation 396 4804 387 4803 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_111080.1 Spry regulation of FGF signaling 10253 5781 673 867 7314 8569 7316 7311 5518 5515 5516 5594 6233 5595 FREE FATTY ACID RECEPTORS%REACTOME%REACT_21268.3 Free fatty acid receptors 2867 2864 2865 338557 2853 G2 M TRANSITION%REACTOME%REACT_2203.6 G2 M Transition 9133 1017 1022 8945 6500 902 7311 84962 27175 55957 984 132660 8454 8900 3320 7465 4331 7316 983 890 993 6233 994 1781 1778 203068 9662 22897 10733 80254 11064 10121 10142 7532 55142 4957 7840 5108 5519 1453 22994 5518 80321 9702 5515 121441 5516 5928 4751 7277 1069 10806 8481 22995 55722 8655 5347 55835 55125 80184 10383 79959 10382 10540 23291 11190 8636 9814 9738 22981 55755 7283 7314 84131 23332 5116 95681 11258 7846 11116 1063 5048 22919 9088 891 5577 9793 5566 5520 7531 2033 91750 1454 995 27229 85378 54820 10426 114791 728642 2305 5500 10133 4659 4605 4218 6790 79866 286826 10844 4926 7514 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_169318.2 Defective MMAB causes methylmalonic aciduria type cblB 55191 4552 1719 4548 32 4594 31 23475 9446 5743 5646 8029 5645 55229 5644 25974 55312 81034 316 53354 55163 8034 6947 10560 55034 81693 9962 3141 9963 56922 60496 60490 27010 8566 166785 23057 5095 326625 5096 101929880 440387 101928493 6948 6470 1504 51293 349565 80025 64087 4338 27249 4524 54 6573 51248 113278 80347 101928717 2694 5091 4522 119391 113235 27304 65220 80704 79178 200895 6515 6513 93100 5167 55788 8884 80308 5740 1528 79717 4363 1582 2194 1727 10135 686 64802 10243 79646 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME%REACT_15296.2 Recruitment of mitotic centrosome proteins and complexes 11116 27175 984 5048 22919 891 3320 5577 9793 5566 983 1781 1778 203068 9662 22897 10733 7531 80254 11064 10121 10142 7532 55142 4957 7840 5108 1453 22994 5518 80321 9702 121441 4751 1454 7277 1069 10806 8481 22995 55722 8655 5347 55835 55125 80184 27229 85378 10383 79959 54820 10426 10382 10540 11190 114791 8636 9814 728642 9738 22981 55755 7283 84131 23332 5116 95681 11258 7846 10844 4926 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME%REACT_15525.4 Nuclear Receptor transcription pathway 5465 7181 2103 2104 2099 2101 29959 7421 5916 6097 5915 4929 5914 5467 6096 5469 5468 367 6095 3172 5241 8431 7101 3174 7068 126382 2100 3164 9975 2516 7067 7182 6256 7376 6258 9572 7025 6257 2063 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_75829.5 PIP3 activates AKT signaling 6199 3815 2932 23035 572 2064 2549 1950 5291 5293 1026 27161 3667 2534 5728 117145 145957 79109 2931 5290 1027 4343 8503 1956 2309 5156 8660 5781 7409 2069 26523 5155 7249 3164 2475 1839 3932 23239 842 1147 50852 152831 253260 2264 9965 1385 940 3084 685 57690 942 941 84335 64223 26281 101060747 10818 5296 4193 9542 192669 930 5170 5159 23112 57761 10718 5295 10000 2247 2246 192670 2249 2255 8823 207 27006 208 2251 2252 2254 2308 2248 8817 8074 27327 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME%REACT_15428.4 Regulation of IGF Activity by IGFBP 2999 4312 3817 1511 3487 3488 354 3481 2147 3489 4313 5069 3816 5340 3484 3483 26085 3485 3479 3486 60676 SYNTHESIS OF KETONE BODIES%REACTOME%REACT_1464.4 Synthesis of Ketone Bodies 3155 38 3158 622 AXIN MISSENSE MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME%REACT_228285.1 AXIN missense mutants destabilize the destruction complex 5711 5710 5714 5713 1452 5719 3065 8945 2932 7089 23198 139285 7088 6500 5715 5716 1499 5701 7311 5696 5687 5695 5700 166 5694 6932 6934 5717 5718 5688 5689 8454 8312 5720 7316 10213 324 5698 83439 9978 5699 7090 7091 10023 143471 5721 6233 5519 5518 5515 5516 5529 1487 5528 1488 5527 23401 10197 5707 5525 5706 5709 5708 5690 5705 5691 5704 5526 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 51176 5684 5683 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_378.3 Repair synthesis of patch ~27-30 bases long by DNA polymerase 5111 5982 5981 5427 5983 6119 6118 57804 6117 5426 5425 5424 10714 5985 5984 ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME%REACT_15548.2 Enzymatic degradation of dopamine by COMT 1312 4128 MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_16943.1 Muscarinic acetylcholine receptors 1128 1133 1132 1131 1129 TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME%REACT_75880.1 Tandem pore domain halothane-inhibited K+ channel (THIK) 56659 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_121147.2 alpha-linolenic acid (ALA) metabolism 3295 215 9415 54898 3992 2180 10005 60481 6342 100302263 30 CA ACTIVATED K+ CHANNELS%REACTOME%REACT_75896.1 Ca activated K+ channels 3782 3781 3783 10242 27345 27094 3779 3778 3780 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_163699.2 Scavenging by Class A Receptors 1282 2512 5648 7184 335 338 1284 100500842 1278 811 286133 1277 78989 4481 81035 2495 1281 348 8685 117156 PROCESSING OF DNA ENDS PRIOR TO END REJOINING%REACTOME%REACT_1201.5 Processing of DNA ends prior to end rejoining 55775 7520 2547 5591 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_169107.2 SMAD4 MH2 Domain Mutants in Cancer 1030 1875 1874 3065 1025 1024 7048 56288 7046 60436 5045 7040 54778 9040 56937 7311 100527943 11171 142 904 51377 57154 23645 905 64750 7029 2280 4088 7316 4089 9110 9958 5590 7027 57530 5499 6233 4087 25805 23327 4609 50855 387 4221 10273 7050 6667 51592 6497 50848 5054 6498 892 4092 7323 3726 7321 5500 867 5501 7314 9612 9611 25937 8239 5933 4738 101929368 23370 5494 7514 REGULATION OF IFNA SIGNALING%REACTOME%REACT_25216.1 Regulation of IFNA signaling 7297 3439 5781 3451 3443 3444 3454 3452 3448 3449 11274 3445 3446 5777 9021 5770 3456 6773 8651 3442 3716 3440 3441 LEUKOTRIENE RECEPTORS%REACTOME%REACT_18302.1 Leukotriene receptors 56413 1241 2840 10800 57105 PLATELET SENSITIZATION BY LDL%REACTOME%REACT_23879.1 Platelet sensitization by LDL 5529 5528 5527 5781 5525 338 2268 5526 1432 5777 5519 5518 5321 5515 5516 5175 7804 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_20546.1 Ras activation uopn Ca2+ infux through NMDA receptor 801 805 808 88 1742 816 817 2902 818 10142 2904 4747 815 5923 2905 5924 2906 3265 2903 VEGFA-VEGFR2 PATHWAY%REACTOME%REACT_228166.1 VEGFA-VEGFR2 Pathway 5603 857 9475 6093 5063 5062 5604 5747 5605 4690 10006 5058 5921 25759 1398 10458 7410 3265 5879 9844 5335 3320 7409 3791 26999 6300 10810 5580 983 7867 2475 1003 5894 5578 253260 801 805 7297 808 3708 3728 3709 1432 3845 6461 64223 4893 101060747 3717 5170 57761 5595 5600 5579 1495 2185 63916 1500 5594 5829 558 8877 8440 9564 1535 9047 5291 1536 3569 3690 3685 653361 2534 3570 117145 79109 4689 5290 9261 4688 5781 10451 10152 5568 5567 4846 10787 5566 3710 5590 10163 387 8936 1793 7529 5296 3315 3716 5295 10000 207 208 998 55845 INTERLEUKIN-1 PROCESSING%REACTOME%REACT_23950.1 Interleukin-1 processing 3553 4791 5970 3552 4790 3606 834 LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME%REACT_7964.3 Lectin pathway of complement activation 2219 8547 5648 4153 2220 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME%REACT_1874.3 Homologous Recombination Repair 83990 5893 10111 6119 6118 6117 5888 4361 672 3978 7158 472 9656 4683 3014 675 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_150260.2 Condensation of Prometaphase Chromosomes 9133 983 891 64151 1459 10592 23397 1457 9918 1460 10051 SYNTHESIS OF PI%REACTOME%REACT_121000.2 Synthesis of PI 1040 10423 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%REACT_1767.3 SMAC-mediated dissociation of IAP:caspase complexes 840 56616 836 331 842 SCAVENGING BY CLASS H RECEPTORS%REACTOME%REACT_164002.2 Scavenging by Class H Receptors 23166 55576 338 6678 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_121096.2 EGFR Transactivation by Gastrin 3845 4314 4893 1839 3265 6654 1956 5578 ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME%REACT_21343.1 Activation of Na-permeable Kainate Receptors 2897 2898 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_147788.2 MPS IIIB - Sanfilippo syndrome B 23563 10331 2239 3373 79586 9469 3339 126792 9653 3073 3340 3074 6383 11285 10678 9435 3038 9394 10675 3037 3036 2720 283464 8372 100616124 2719 727936 4958 9957 11041 9956 9955 633 3425 1634 3423 11046 79369 27087 9348 347734 11081 411 176 63827 6382 643853 6385 8509 8702 26035 8704 8703 9331 10855 9334 4969 10861 2262 10057 29940 2990 64579 2817 2132 2131 60495 960 55454 10082 6482 6483 6487 6484 1836 6548 135152 56548 266722 10402 51363 22856 221914 222537 93010 10090 10894 55576 2799 6448 8692 337876 26229 90161 64711 166012 11261 375790 3161 113189 5549 9951 9953 9672 1463 4669 2331 51000 8534 50515 4060 1464 9060 1462 55790 2683 92126 55501 4166 9061 79411 54480 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME%REACT_19268.1 Nectin Necl trans heterodimerization 57863 5818 5817 23705 5819 25945 81607 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_115831.1 ISG15 antiviral mechanism 7324 51191 26781 10762 6043 7311 619567 619568 5903 55746 7318 6772 100302143 8480 1974 5335 1973 1977 23586 100847079 7316 23165 3661 5300 23279 79902 7334 7706 6233 348995 9246 652965 652966 9631 9636 677847 53371 4927 5610 8086 8021 4599 129401 7175 9883 1981 3716 3434 5595 4734 5495 4600 3836 9688 7314 11274 23225 3837 3839 3838 3841 9972 3840 1982 11097 2317 57122 25820 373856 9775 9470 8672 23511 402569 317649 79023 23636 MYD88-INDEPENDENT CASCADE%REACTOME%REACT_6809.8 MyD88-independent cascade 330 148022 7322 329 10010 11035 5604 7187 9641 5605 100302736 7311 3656 23118 7336 1845 1848 3654 1849 7099 466 1846 2353 10454 100996792 3665 929 7316 64127 5608 983 7867 3661 6285 353376 4791 29110 5598 7098 177 5599 1660 7334 7335 1147 6283 7189 6233 7297 1385 1432 5519 5518 5515 5516 3717 5595 5600 7323 5528 8517 6195 7321 6197 7314 6196 5970 4792 5594 4793 4790 6885 3551 3569 3570 9261 5781 6288 5606 9252 23643 5601 5602 10392 1386 3146 2002 8767 4615 257397 6416 3725 4205 351 4208 3716 8772 8737 841 5609 RELAXIN RECEPTORS%REACTOME%REACT_21314.1 Relaxin receptors 10022 51289 117579 122042 3640 6019 59350 339403 GLYCOGEN SYNTHESIS%REACTOME%REACT_169208.2 Glycogen synthesis 2997 2998 7957 378884 5507 2632 7314 7316 7311 7360 8908 5236 55276 2992 6233 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME%REACT_6913.3 Cytosolic sulfonation of small molecules 10861 6799 101929857 347734 6783 9060 6819 10380 100616124 27284 25830 6817 6818 9061 27233 445329 6822 1836 51000 TRP CHANNELS%REACTOME%REACT_169333.2 TRP channels 54822 255231 80036 54795 4308 7220 51393 59341 8989 162514 29850 57113 57192 55283 55503 56302 7442 7225 79054 7222 26133 7223 7224 7226 140803 SIGNALING BY LEPTIN%REACTOME%REACT_169118.2 Signaling by Leptin 7297 6774 8660 5781 3952 5604 5605 7529 9021 3845 983 3569 4893 3667 3717 3265 3570 5594 6777 3716 6776 5595 5894 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_160301.1 Signaling by NOTCH1 PEST Domain Mutants in Cancer 3066 3714 6868 3065 3280 6907 54492 1024 7089 408 409 7088 23462 6500 3091 7311 2648 8650 83464 113878 10014 51107 1272 8454 9794 26508 10013 102 84441 101928143 23493 4851 8788 5664 7316 142678 22938 9759 9978 10046 7091 54567 57534 83737 6233 51564 55851 79885 4609 9148 2033 55869 55534 182 892 8841 101930388 3516 28514 388585 83933 9734 1387 7314 9612 9611 92737 1840 8850 79718 23220 23385 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME%REACT_20582.1 Zinc efflux and compartmentalization by the SLC30 family 55676 148867 7779 7781 169026 7780 64924 TRANSLESION SYNTHESIS BY POL ZETA%REACTOME%REACT_822.3 Translesion synthesis by Pol zeta 10459 5980 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_163862.2 Cobalamin (Cbl, vitamin B12) transport and metabolism 4552 166785 4548 4594 55788 326625 440387 5646 6948 4363 8029 1504 5645 51293 5644 25974 27249 6947 81693 2694 GAP JUNCTION TRAFFICKING%REACTOME%REACT_9411.1 Gap junction trafficking 10052 81025 10804 57165 375519 8218 101926921 1785 1601 1211 2697 2706 2705 127534 1759 1173 4646 219770 125111 1213 1212 2702 2701 2707 2703 84694 2700 57369 2709 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_200751.2 Organelle biogenesis and maintenance 23410 5465 6742 51106 2101 56652 11232 6907 5565 3054 5564 5563 5571 5469 4899 54205 51422 23054 53632 7978 6300 814 211 7019 5442 64216 6256 801 805 808 6604 1385 8648 96764 1386 1432 4208 8841 133522 80205 5600 1387 506 10891 9611 10498 85441 79718 4209 2551 23082 9572 10499 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_75776.1 NOD1 2 Signaling Pathway 835 330 5603 10392 329 8767 1432 257397 64170 3656 5600 23118 837 8517 7336 3654 6300 10454 834 7128 64127 5608 841 1540 728489 842 7334 1147 7335 6885 83737 3551 7189 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_163936.2 Fc epsilon receptor (FCERI) signaling 6199 9402 3815 10235 2932 115727 3702 28442 23035 5063 572 5062 5604 28454 5605 2064 1950 5058 1026 6850 5588 7410 3265 5879 145957 2931 4067 1027 8503 1956 2309 23118 5156 3937 7336 8660 5335 7409 5336 9846 28908 2069 2353 26523 695 10454 5155 7249 983 2475 1839 3932 5599 23239 7334 842 1147 7335 50852 5894 7189 801 253260 805 7297 808 1385 940 3084 685 942 7006 941 3708 3709 3845 84335 64223 4893 101060747 26281 3717 10818 4193 9542 930 5170 5159 57761 23112 10718 5595 8915 2247 2246 84433 8517 2249 2255 10125 8823 27006 2251 2252 2254 2248 8817 8074 10892 2207 28834 5970 5594 2205 4792 2206 4790 6885 3551 3497 28916 28912 2549 5291 5293 27161 3569 3667 2534 5728 3570 117145 79109 5290 4343 5781 10451 28299 7294 3164 7462 3710 3538 152831 2264 9965 4214 3539 5601 5602 57690 100423062 3542 7529 257397 3725 6416 5534 3514 5296 28776 4775 192669 28876 3716 6654 5295 28874 10000 192670 5530 5532 4773 207 4772 208 2308 28896 27327 5609 440786 PLUS-STRAND DNA SYNTHESIS%REACTOME%REACT_9037.2 Plus-strand DNA synthesis 5478 101060363 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_121284.2 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 3295 215 9415 54898 3992 2180 10005 60481 6342 100302263 30 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME%REACT_1949.4 CDT1 association with the CDC6:ORC:origin complex 5711 5710 51053 5714 5713 5719 23198 5715 5716 5701 7311 5696 5687 5695 5700 5694 5717 5718 5688 5689 5001 4999 5000 4998 5720 7316 10213 5698 5699 23595 143471 990 5721 6233 84515 23594 81620 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 5684 5683 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_169445.2 TGFBR1 LBD Mutants in Cancer 1030 1875 1874 3065 1025 1024 7048 56288 7046 60436 5045 7040 54778 9040 56937 7311 100527943 11171 142 904 51377 57154 23645 905 64750 7029 2280 4088 7316 4089 9110 9958 5590 7027 57530 5499 6233 4087 25805 23327 4609 50855 387 4221 10273 7050 6667 51592 6497 50848 5054 6498 892 4092 7323 3726 7321 5500 867 5501 7314 9612 9611 25937 8239 5933 4738 101929368 23370 5494 7514 TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME%REACT_11050.2 Transport of connexons to the plasma membrane 2697 2706 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_1946.1 PKA activation in glucagon signalling 112 115 114 5577 111 113 196883 5576 5573 5568 5567 5566 107 108 2778 109 5575 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_15502.4 CaMK IV-mediated phosphorylation of CREB 801 805 808 1385 814 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_172631.2 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 160 163 1173 161 1175 7855 4919 1213 7474 1212 101927462 1211 2535 4920 HEDGEHOG LIGAND BIOGENESIS%REACTOME%REACT_228111.1 Hedgehog ligand biogenesis 5711 5034 5710 5714 6868 5713 5719 23198 5715 5716 5701 7311 5696 7415 5687 5695 5700 6469 5694 5717 5718 5688 5689 3549 5720 7316 10213 5698 5699 143471 5721 6233 6400 51009 27248 50846 147111 2262 10197 5707 5706 5709 5708 5690 5705 5691 5704 7314 5692 5693 5702 122706 84447 5686 5685 55733 5682 85455 9861 57758 9491 5684 10956 5683 SHC ACTIVATION%REACTOME%REACT_1661.1 SHC activation 3643 3630 6464 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_6954.2 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins 5711 996 5710 5714 5713 7324 5719 9184 991 23198 5715 5716 9232 5701 7311 5696 5687 5695 730268 5700 5694 51433 5717 5718 5688 5689 11065 891 29882 246184 8697 29945 4085 5720 7316 10213 51529 5698 983 5699 143471 701 5721 10393 6233 5347 51434 10197 5707 5706 5709 5708 5690 5705 7321 5691 64682 5704 7314 5692 5693 5702 8881 122706 5686 5685 5682 9861 9491 5684 5683 PACKAGING OF EIGHT RNA SEGMENTS%REACTOME%REACT_6235.4 Packaging of Eight RNA Segments ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME%REACT_1258.3 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 6231 6232 8894 1965 6044 26784 26781 100505503 101929876 6043 85388 619567 1964 1968 619568 6228 6229 6227 6235 6230 7458 6234 100302143 1978 1974 84546 1973 1977 1975 2197 3646 6193 6194 6192 6191 8669 94163 6233 8668 652965 101060318 652966 677847 574040 6224 6223 6222 8663 8661 6203 8662 6201 6202 8666 26811 8667 8665 6189 6188 8664 1981 26795 6187 27335 6210 6205 6204 6208 100996747 100508408 6209 6206 6207 6217 6218 26986 3921 8944 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME%REACT_1095.3 Activation of the pre-replicative complex 5422 1017 84515 4173 23594 4172 5427 23649 5557 5558 8318 81620 55388 8317 10926 29935 5001 4999 5000 6119 6118 4998 6117 4171 5426 4176 4174 4175 23595 990 LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME%REACT_163743.2 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 1387 3661 9208 2033 1499 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME%REACT_23862.1 Nitric oxide stimulates guanylate cyclase 2982 5593 2983 10242 4842 4843 2977 8654 3708 5140 5136 5138 5139 10335 4846 27345 3779 27094 3778 5153 5152 50940 10846 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%REACT_150422.2 Synthesis of 15-eicosatetraenoic acid derivatives 246 247 5743 2879 2877 2876 GAP JUNCTION ASSEMBLY%REACTOME%REACT_9509.2 Gap junction assembly 10052 127534 81025 10804 219770 57165 125111 2702 375519 2701 2697 2707 2706 2705 84694 2703 57369 2700 2709 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME%REACT_15344.1 Chemokine receptors bind chemokines 729230 3579 3577 2829 643 9034 6364 6363 6361 6366 6367 2920 58191 6347 6360 1524 2921 6348 6349 10803 1235 6351 3576 6352 10663 6356 5473 6846 1234 2919 6354 5196 2826 2833 6372 6370 6374 6373 57007 6376 1237 1238 1233 56477 1236 51554 1232 10850 1230 6375 6387 4283 3627 414062 7852 10563 GABA SYNTHESIS%REACTOME%REACT_24020.1 GABA synthesis 2572 2571 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_147739.2 MPS IX - Natowicz syndrome 23563 10331 2239 3373 79586 9469 3339 126792 9653 3073 3340 3074 6383 11285 10678 9435 3038 9394 10675 3037 3036 2720 283464 8372 100616124 2719 727936 4958 9957 11041 9956 9955 633 3425 1634 3423 11046 79369 27087 9348 347734 11081 411 176 63827 6382 643853 6385 8509 8702 26035 8704 8703 9331 10855 9334 4969 10861 2262 10057 29940 2990 64579 2817 2132 2131 60495 960 55454 10082 6482 6483 6487 6484 1836 6548 135152 56548 266722 10402 51363 22856 221914 222537 93010 10090 10894 55576 2799 6448 8692 337876 26229 90161 64711 166012 11261 375790 3161 113189 5549 9951 9953 9672 1463 4669 2331 51000 8534 50515 4060 1464 9060 1462 55790 2683 92126 55501 4166 9061 79411 54480 FORMATION OF THE EDITOSOME%REACTOME%REACT_1390.3 Formation of the Editosome 29974 339 SPERM MOTILITY AND TAXES%REACTOME%REACT_163875.2 Sperm Motility And Taxes 157855 117144 84329 378807 117155 101930343 347732 257062 57828 79820 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_471.3 E2F mediated regulation of DNA replication 5422 1719 6241 84515 23594 7298 23649 898 5925 5557 5558 1869 5519 5518 5515 8318 5516 81620 26271 5111 8900 7084 891 28227 5001 4999 5000 4998 983 7027 23595 990 993 MEK ACTIVATION%REACTOME%REACT_962.4 MEK activation 3845 4893 3265 5604 5605 5894 7529 CREB PHOSPHORYLATION%REACTOME%REACT_12524.1 CREB phosphorylation 9252 1385 6195 466 6197 6196 9261 SCAVENGING OF HEME FROM PLASMA%REACTOME%REACT_160163.3 Scavenging of heme from plasma 3539 3040 3043 9332 28916 28442 259 100423062 4035 28454 3542 28912 3039 3493 3514 3494 3263 28776 3240 3250 28876 8542 28874 335 28908 28299 28896 213 28834 3538 440786 GRB2 EVENTS IN EGFR SIGNALING%REACTOME%REACT_12606.2 GRB2 events in EGFR signaling 7297 5781 5604 5605 7529 3845 1950 983 3569 4893 3717 3265 3570 5594 3716 6654 1956 5595 5894 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_121314.2 Heparan sulfate heparin (HS-GAG) metabolism 135152 2239 266722 3339 126792 9653 3340 221914 222537 6383 11285 9394 10675 2720 283464 2719 727936 6448 9957 26229 9956 9955 633 90161 3425 1634 3423 11046 27087 64711 9348 375790 9951 9953 9672 6382 63827 643853 6385 8509 26035 1463 4669 10855 2262 2990 64579 2817 1464 2132 2131 60495 1462 10082 79411 G-PROTEIN MEDIATED EVENTS%REACTOME%REACT_15526.2 G-protein mediated events 801 805 156 808 1385 5330 5332 5582 5331 3708 3709 2779 107 108 109 2771 5153 2781 2770 112 115 114 111 5577 5137 2774 113 346562 196883 2773 814 5576 5136 5573 5568 5567 5580 5566 5321 3710 5594 2780 2775 5575 23236 5578 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_169169.2 Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC 55191 4552 1719 4548 32 4594 31 23475 9446 5743 5646 8029 5645 55229 5644 25974 55312 81034 316 53354 55163 8034 6947 10560 55034 81693 9962 3141 9963 56922 60496 60490 27010 8566 166785 23057 5095 326625 5096 101929880 440387 101928493 6948 6470 1504 51293 349565 80025 64087 4338 27249 4524 54 6573 51248 113278 80347 101928717 2694 5091 4522 119391 113235 27304 65220 80704 79178 200895 6515 6513 93100 5167 55788 8884 80308 5740 1528 79717 4363 1582 2194 1727 10135 686 64802 10243 79646 SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME%REACT_118560.3 Small interfering RNA (siRNA) biogenesis 192670 27161 23405 192669 6895 8575 26523 FMO OXIDIZES NUCLEOPHILES%REACTOME%REACT_13653.1 FMO oxidizes nucleophiles 2326 2328 2327 HEME DEGRADATION%REACTOME%REACT_22297.1 Heme degradation 645 644 54658 3163 3162 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME%REACT_19259.1 Sema4D in semaphorin signaling 391 3984 3985 5364 388 4627 387 9475 389 6093 23365 5880 2064 2909 103910 79784 27289 10398 4637 5879 6237 4629 4628 998 4233 10507 9826 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_121399.2 MHC class II antigen presentation 3115 100509457 3117 3119 3118 10437 100507709 3113 3122 9632 1785 100996809 100507714 101060835 3120 3123 26052 3797 22920 3832 100500810 3835 29127 3831 9371 11127 285643 26153 56992 3125 3126 3127 89953 1781 1778 10121 821 8907 8905 1211 10112 8655 9493 10540 10053 6712 11258 1509 160 164 163 162 1062 161 3796 51128 81930 1174 1173 1175 84643 375 6456 10802 10427 6396 1639 1520 51626 84516 10120 130340 1514 1513 22872 1515 1508 101927462 1075 9871 114876 7879 83547 79659 1780 64837 11004 1759 1783 10671 1510 1519 147700 1512 24137 8722 972 3108 3109 140735 3112 3111 3799 10484 51164 3798 5641 5476 LAGGING STRAND SYNTHESIS%REACTOME%REACT_312.5 Lagging Strand Synthesis 5422 5111 5982 5981 5983 2237 23649 6119 5557 6118 6117 57804 5558 5425 5424 3978 10714 5985 5984 1763 SYNTHESIS OF PG%REACTOME%REACT_121280.2 Synthesis of PG 23646 5337 5338 114971 8760 122618 9489 201164 SIGNALING BY ERBB2%REACTOME%REACT_115755.4 Signaling by ERBB2 6199 3815 2932 5581 23035 5582 572 5604 5605 2064 1950 7311 7525 1026 10193 3265 145957 2931 1027 8503 1956 6714 2309 5156 8660 112 5335 115 114 3320 7409 5137 111 2069 113 26523 196883 5155 814 7316 7249 5580 983 2475 4145 1839 3932 23239 9101 842 1147 50852 6233 5894 5578 253260 801 156 805 7297 808 1385 940 3084 685 942 941 11140 3708 3709 10273 3845 84335 64223 4893 26281 101060747 3717 10818 4193 9542 930 5170 5159 5153 23112 57761 10718 5595 2247 2246 2249 2255 8823 8065 27006 2251 2252 2254 7314 2248 8817 8074 5594 2549 5291 5293 27161 3569 3667 2534 5728 3570 117145 79109 5290 4343 5781 5577 5576 5136 5573 5568 5567 3164 5566 3710 6464 5575 152831 2264 9965 57690 7529 107 5296 108 192669 109 3716 6654 5295 10000 192670 207 208 2308 27327 55914 2886 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_118713.2 YAP1- and WWTR1 (TAZ)-stimulated gene expression 8463 5465 6604 8648 96764 6907 10413 5469 23054 80205 1490 1387 7004 7005 7003 25937 10498 85441 8850 79718 6910 4878 6256 860 10499 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME%REACT_1364.3 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 22916 6637 84967 25888 134353 7884 6634 4686 6635 6636 6628 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_120996.2 Hyaluronan uptake and degradation 6548 10894 3073 8692 11261 3074 2990 55576 3373 3161 8372 960 FANCONI ANEMIA PATHWAY%REACTOME%REACT_18410.1 Fanconi Anemia pathway 91442 2188 2189 2178 2187 55120 7398 7314 27033 545 2175 7316 7311 57697 672 79728 2177 2176 29089 472 675 55215 6233 80233 SIGNALING BY EGFR%REACTOME%REACT_9417.7 Signaling by EGFR 6199 3815 2932 5581 23035 5582 572 5604 5605 2064 1950 7311 1026 3265 145957 2931 1027 8503 1956 2309 5156 8660 112 5335 115 8874 114 7409 5137 111 2069 113 26523 196883 5155 814 7316 7249 5580 983 2475 1839 3932 2060 23239 842 1147 50852 6233 5894 5578 253260 801 156 805 7297 808 1385 940 3084 685 9146 942 941 3708 3709 3845 84335 64223 4893 26281 101060747 1211 3717 10818 4193 9542 930 5170 5159 29924 57761 23112 5153 10718 5595 10253 2247 2246 2249 2255 8823 27006 2251 26018 2252 867 2254 7314 2248 8817 8074 1445 5594 5829 160 6868 163 161 2549 8038 5291 5293 27161 58513 3569 3667 2534 5728 3570 117145 79109 8027 5290 4343 5781 1173 102 5577 1175 5136 5576 5573 5568 30011 5567 3164 5566 6456 3710 6464 5575 152831 2264 9965 55824 57690 7529 101927462 107 5296 108 192669 109 3716 6654 5295 10000 192670 207 208 998 2308 27327 10254 10252 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME%REACT_19397.2 Transport of inorganic cations anions and amino acids oligopeptides 6548 83697 153201 6550 117247 23315 6553 9056 9057 5172 6549 6560 6564 6565 389015 6505 6506 55089 57835 121260 6509 6512 6522 6520 6575 11254 6519 123041 6574 54407 6546 81539 6568 6569 11136 57419 23428 57468 160728 6547 6533 57084 340024 8140 6541 80024 26503 10568 115111 92745 246213 6559 285195 6543 57030 6511 8671 6508 6507 54716 142680 283652 6557 6510 6521 6558 140679 206358 10861 84679 115019 9187 10991 23657 6539 55117 84889 10479 1811 1468 10723 6528 124935 9990 56301 348932 51296 25769 9497 8501 1836 65010 57282 9498 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_200812.2 Transcriptional regulation of pluripotent stem cells 57167 2034 2247 6774 9314 79727 63978 64344 6657 27022 7547 5087 79923 6997 4089 5460 2041 2516 84891 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_163910.2 NOTCH2 intracellular domain regulates transcription 4853 1385 9794 55534 3280 10046 2208 84441 3002 3516 2033 388585 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME%REACT_25222.2 MyD88 dependent cascade initiated on endosome 5604 5605 7311 3569 3570 54106 9261 3656 23118 51295 7336 1845 5781 1848 3654 51284 1849 6288 466 1846 2353 10454 100996792 170506 3665 7316 246330 64127 5608 7867 983 6285 4791 5598 177 5599 1660 7334 7335 1147 51311 6283 6233 7189 5606 9252 7297 4214 1385 5601 57161 5602 10392 1386 51135 57162 3146 2002 8767 1432 4615 257397 5519 3725 6416 5518 4205 351 5515 5516 4208 3717 3716 5595 5600 5528 8517 6195 6197 7314 6196 5970 4792 5594 4793 5609 4790 6885 3551 MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME%REACT_20619.2 mRNA decay by 3' to 5' exoribonuclease 23016 28960 54512 22894 5393 118460 51010 23404 56915 11340 51013 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_147723.2 PI3K AKT Signaling in Cancer 6199 3815 2932 23035 572 2064 2549 1950 5291 5293 1026 27161 3667 2534 5728 117145 145957 79109 2931 5290 1027 4343 8503 1956 2309 5156 8660 5781 7409 2069 26523 5155 7249 3164 2475 1839 3932 23239 842 1147 50852 152831 253260 2264 9965 1385 940 3084 685 57690 942 941 84335 64223 26281 101060747 10818 5296 4193 9542 192669 930 5170 5159 23112 57761 10718 5295 10000 2247 2246 192670 2249 2255 8823 207 27006 208 2251 2252 2254 2308 2248 8817 8074 27327 TRISTETRAPROLIN (TTP) DESTABILIZES MRNA%REACTOME%REACT_25064.2 Tristetraprolin (TTP) destabilizes mRNA 23016 54512 5393 118460 55802 51010 23404 51013 54464 7529 167227 22894 7538 3842 56915 11340 9261 EGFR DOWNREGULATION%REACTOME%REACT_12484.1 EGFR downregulation 160 9146 163 161 1950 7311 58513 101927462 1211 8027 29924 1956 10253 8874 1173 998 867 7314 1175 7316 10254 10252 30011 6456 2060 6233 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_120736.3 Signaling by FGFR in disease 6199 3815 8805 7750 2932 5581 23035 5582 572 5604 1523 5605 2064 1950 7311 1026 3265 145957 6777 2931 1027 8503 1956 399687 2309 5156 8660 112 5335 115 114 7409 9846 5137 111 2069 113 26523 196883 5155 814 7316 11052 7249 5580 983 2475 1839 3932 23239 842 1147 50852 6233 5894 5578 801 253260 805 156 7297 808 1385 940 3084 685 942 941 3708 3709 3845 84335 5518 64223 5515 4893 5516 26281 101060747 3717 10818 4193 9542 930 5170 5159 57761 23112 5153 10718 5595 10253 2247 2261 2246 2249 2255 8823 2263 673 9208 27006 2251 2252 867 2254 7314 2248 8817 2260 8569 8074 5594 11116 2549 5291 5293 27161 3569 3667 2534 5728 3570 117145 79109 5290 4343 10817 6772 6774 5781 5577 5136 5576 5573 5568 5567 3164 5566 3710 26127 5575 152831 2264 9965 57690 7529 107 5296 108 192669 109 3716 6776 6654 5295 10000 192670 613 207 208 2308 27327 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_169122.2 Signaling by TGF-beta Receptor Complex in Cancer 1030 1875 1874 3065 1025 1024 7048 56288 7046 60436 5045 7040 54778 9040 56937 7311 100527943 11171 142 904 51377 57154 23645 905 64750 7029 2280 4088 7316 4089 9110 9958 5590 7027 57530 5499 6233 4087 25805 23327 4609 50855 387 4221 10273 7050 6667 51592 6497 50848 5054 6498 892 4092 7323 3726 7321 5500 867 5501 7314 9612 9611 25937 8239 5933 4738 101929368 23370 5494 7514 DEGRADATION OF DVL%REACTOME%REACT_200841.2 degradation of DVL 5711 5710 23072 5714 5713 5719 23198 5715 5716 5701 7311 5696 5687 5695 5700 5694 5717 5718 5688 59349 5689 1857 1856 1855 5720 7316 10213 5698 9978 5699 143471 5721 6233 51339 10197 5707 5706 5709 5708 5690 8452 5705 5691 5704 7314 5692 5693 5702 122706 5686 5685 5682 9861 9491 5684 5683 IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME%REACT_118811.2 IRF3 mediated activation of type 1 IFN 147945 3661 29110 81030 23220 340061 CD28 DEPENDENT VAV1 PATHWAY%REACTOME%REACT_19238.1 CD28 dependent Vav1 pathway 5058 940 2534 7409 942 998 3932 941 5063 5879 5062 OXIDATIVE DEMETHYLATION OF DNA%REACTOME%REACT_200682.2 Oxidative demethylation of DNA 80312 6996 200424 54790 SYNTHESIS OF LIPOXINS (LX)%REACTOME%REACT_150320.2 Synthesis of Lipoxins (LX) 3248 239 22949 4056 240 241 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_147719.2 MPS VI - Maroteaux-Lamy syndrome 23563 10331 2239 3373 79586 9469 3339 126792 9653 3073 3340 3074 6383 11285 10678 9435 3038 9394 10675 3037 3036 2720 283464 8372 100616124 2719 727936 4958 9957 11041 9956 9955 633 3425 1634 3423 11046 79369 27087 9348 347734 11081 411 176 63827 6382 643853 6385 8509 8702 26035 8704 8703 9331 10855 9334 4969 10861 2262 10057 29940 2990 64579 2817 2132 2131 60495 960 55454 10082 6482 6483 6487 6484 1836 6548 135152 56548 266722 10402 51363 22856 221914 222537 93010 10090 10894 55576 2799 6448 8692 337876 26229 90161 64711 166012 11261 375790 3161 113189 5549 9951 9953 9672 1463 4669 2331 51000 8534 50515 4060 1464 9060 1462 55790 2683 92126 55501 4166 9061 79411 54480 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_25039.1 NF-kB activation through FADD RIP-1 pathway mediated by caspase-8 and -10 57506 8517 841 843 23586 84282 8772 7706 1147 8737 64135 3551 NUCLEAR IMPORT OF REV PROTEIN%REACTOME%REACT_9395.2 Nuclear import of Rev protein 9631 53371 10762 4927 55746 8021 8086 5903 129401 9883 7175 8480 4869 5901 9688 23225 3837 9972 23165 11097 1104 57122 23279 79902 23511 79023 348995 23636 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_25060.1 Iron uptake and transport 9843 1356 537 527 3163 528 3162 526 525 523 261729 9114 55240 529 2495 9296 51382 50617 23545 57192 10312 245973 8992 2512 245972 79901 28982 4891 127124 101927180 533 7018 534 7037 535 90423 51606 155066 9550 9429 30061 113235 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_172599.2 WNT5A-dependent internalization of FZD4 1856 160 5579 163 1173 5582 409 161 1175 1213 7474 1212 101927462 1211 8322 5578 SYNTHESIS AND PROCESSING OF GAG, GAGPOL POLYPROTEINS%REACTOME%REACT_115860.5 Synthesis And Processing Of GAG, GAGPOL Polyproteins 7311 7316 9397 7251 155382 55048 7314 79720 137492 51160 6233 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME%REACT_2122.3 ChREBP activates metabolic gene expression 47 6945 32 51085 31 2194 10554 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_163769.2 Role of LAT2 NTAL LAB on calcium mobilization 6199 3815 2932 28442 23035 572 28454 2064 1950 1026 6850 145957 2931 4067 1027 1956 8503 2309 5156 8660 7409 9846 2069 28908 26523 5155 7249 2475 1839 3932 23239 842 1147 50852 253260 1385 940 3084 685 942 941 84335 64223 26281 101060747 10818 4193 9542 930 5170 5159 23112 57761 10718 2247 2246 2249 2255 8823 27006 2251 2252 2254 2248 8817 8074 28834 3497 28916 28912 2549 5291 5293 27161 3667 2534 5728 117145 79109 5290 4343 5781 28299 3164 7462 3538 152831 2264 3539 9965 57690 100423062 3542 3514 5296 28776 192669 28876 6654 5295 10000 28874 192670 207 208 2308 28896 27327 440786 THYROXINE BIOSYNTHESIS%REACTOME%REACT_15292.3 Thyroxine biosynthesis 6528 1081 1734 1733 389434 7173 1735 7252 RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_22393.2 Respiratory electron transport 1350 55967 1351 1340 116228 1349 1537 1345 4696 4695 4694 10128 54205 285521 6341 4535 4731 4728 4539 100616403 4724 4537 4729 9167 4536 4698 4697 84987 27089 9997 100532726 4711 4722 29796 51241 4514 4726 6390 4723 6392 4720 4725 6391 2110 6389 7384 2108 2109 4702 4701 4700 4716 4718 54539 4717 4712 4719 1327 4713 4714 4540 4538 4710 4715 4541 6834 4709 1329 4707 51204 4708 4706 374291 4704 9377 4705 440567 126328 7381 7388 1353 51079 7385 7386 4519 10975 1337 4513 4512 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_11054.1 Synthesis of bile acids and bile salts 3295 10858 80270 8648 10005 11001 8309 23600 1581 101930400 8644 1109 1593 1646 5740 1582 9023 9420 6718 570 8647 1645 9971 6256 51302 10998 10499 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_185.2 SLBP independent Processing of Histone Pre-mRNAs 22916 6637 84967 25888 134353 6634 4686 6635 6636 6628 PI METABOLISM%REACTOME%REACT_121175.2 PI Metabolism 377 9108 8871 8867 5291 5293 5288 5728 8776 8395 5287 5290 8503 146850 100500810 3631 375 285540 9110 9107 5289 8898 5286 56623 8821 30849 55697 55300 4534 200576 9896 55361 64419 7179 23396 51763 5296 23760 23533 5295 22908 5298 5294 4952 5297 27124 8897 8394 3635 8396 93492 3636 5305 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_169363.2 Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF 55191 4552 1719 4548 32 4594 31 23475 9446 5743 5646 8029 5645 55229 5644 25974 55312 81034 316 53354 55163 8034 6947 10560 55034 81693 9962 3141 9963 56922 60496 60490 27010 8566 166785 23057 5095 326625 5096 101929880 440387 101928493 6948 6470 1504 51293 349565 80025 64087 4338 27249 4524 54 6573 51248 113278 80347 101928717 2694 5091 4522 119391 113235 27304 65220 80704 79178 200895 6515 6513 93100 5167 55788 8884 80308 5740 1528 79717 4363 1582 2194 1727 10135 686 64802 10243 79646 TCR SIGNALING%REACTOME%REACT_12526.2 TCR signaling 3115 9402 100509457 3117 28577 3119 3118 916 915 3702 5063 7454 5062 27040 100507709 55740 3113 51466 4690 3122 5291 5058 920 5588 917 5728 100996809 100507714 101060835 3120 2533 5290 3123 28639 23118 3937 7336 5335 5788 7535 28755 3125 3126 3127 3932 7334 1147 7335 50852 7189 55824 8767 101060747 5296 5170 5295 8915 7408 84433 8517 10892 1445 5970 4792 4790 3635 6885 3551 ACYL CHAIN REMODELLING OF PI%REACTOME%REACT_120722.2 Acyl chain remodelling of PI 79887 100652777 11145 79143 255189 64600 123745 30814 26279 81579 8605 283748 5320 5322 5319 5321 8399 TOLERANCE OF REACTIVE OXYGEN PRODUCED BY MACROPHAGES%REACTOME%REACT_121009.3 Tolerance of reactive oxygen produced by macrophages COPI MEDIATED TRANSPORT%REACTOME%REACT_11096.3 COPI Mediated Transport 9276 1315 375 8729 22818 11316 22820 1314 372 100500810 55738 THE FATTY ACID CYCLING MODEL%REACTOME%REACT_6258.1 The fatty acid cycling model 7352 7350 7351 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_424.3 Transport of the SLBP independent Mature mRNA 9631 53371 10762 4927 10189 55746 8021 8086 5903 129401 9883 7175 8480 22916 1977 9688 4686 23225 9972 23165 11097 57122 23279 10482 79902 23511 79023 348995 23636 MEIOTIC SYNAPSIS%REACTOME%REACT_75792.2 Meiotic synapsis 93426 8335 7014 8334 7013 23345 54386 8337 50511 8331 255626 56158 8468 4001 5885 128312 23224 3306 9126 23353 6847 8359 8338 8339 474382 8347 8348 8345 8346 8340 8343 8344 8341 8342 85236 8360 8362 8361 8364 54145 8363 8365 8366 8970 8368 8349 8367 25913 3013 256126 3012 10388 26277 10734 723790 10735 8294 7329 9985 10274 25777 545 8290 672 554313 27127 121504 3015 3014 8370 65057 3018 3017 8243 HS-GAG DEGRADATION%REACTOME%REACT_120752.2 HS-GAG degradation 2262 2239 2990 375790 2720 2817 60495 2719 3339 9672 6382 643853 6448 10082 221914 6385 79411 6383 4669 3425 10855 3423 PCP CE PATHWAY%REACTOME%REACT_172581.2 PCP CE pathway 5711 5710 5714 5713 160 5719 163 23198 409 5582 161 5715 5716 7481 5701 7311 5696 5687 5695 5700 5694 8323 2535 8325 5717 5879 8321 5718 8322 57154 5688 5689 64750 1857 1856 8324 144165 23513 1173 81029 1855 1175 4919 5720 1213 7316 1212 10213 5698 5699 7976 23002 5216 6259 57216 143471 5721 6233 4920 5578 50855 387 5881 5880 101927462 1211 10197 5707 5579 5706 5709 5708 7471 5690 5705 5691 5704 7314 5692 5693 5702 7855 7474 122706 54361 5686 5685 5682 9861 9491 5684 5683 INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME%REACT_939.2 Insulin effects increased synthesis of Xylulose-5-Phosphate 6888 7086 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_163813.2 Scavenging by Class F Receptors 10525 811 338 3320 8578 10808 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME%REACT_25026.1 TRAF3-dependent IRF activation pathway 1387 80143 57506 23586 7187 64135 2033 9641 3665 3661 29110 3456 84282 7706 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME%REACT_1785.4 Citric acid cycle (TCA cycle) 1743 6390 3419 3418 6392 6391 6389 1738 50 2271 4967 3421 8801 1431 4191 3420 8802 8803 23530 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_6761.2 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 5711 996 5710 5714 5713 7324 5719 991 23198 5715 5716 9232 5701 7311 5696 5687 5695 730268 5700 5694 51433 5717 5718 5688 5689 11065 51343 6502 29882 9212 246184 8697 29945 5720 7316 10213 51529 5698 5699 143471 5721 10393 6233 5347 51434 10197 5707 5706 5709 5708 5690 5705 7321 5691 64682 5704 7314 5692 5693 5702 8881 122706 6790 5686 5685 5682 9861 9491 5684 5683 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_150188.2 Synthesis of pyrophosphates in the cytosol 11165 117283 9677 9807 64768 23262 3705 11163 55190 170685 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_963.2 Apoptotic factor-mediated response 840 56616 836 331 317 54205 842 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_115654.1 Degradation of cysteine and homocysteine 23474 1036 7263 1491 6821 51380 1468 58472 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_75770.1 Voltage gated Potassium channels 3790 3739 3738 3737 3736 3747 27012 3745 3750 9196 3748 8514 9312 23415 3787 3786 23416 3785 3784 3788 170850 56479 93107 3754 3752 3751 3757 3756 3755 131096 9132 3744 3746 81033 3749 3743 7881 26251 3741 3742 90134 169522 27133 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_23887.1 Aquaporin-mediated transport 100509620 282679 362 112 115 114 59345 8766 94235 360 5577 111 361 113 196883 5576 5573 5568 5567 5566 22841 551 554 4645 358 5575 359 2785 2786 2783 51764 2784 2787 2788 2791 55970 107 108 54331 2778 2793 10681 109 2792 2790 363 4284 364 366 101930168 89872 2782 343