ANDROGEN RECEPTOR NETWORK IN PROSTATE CANCER%WIKIPATHWAYS_20260610%WP2263%HOMO SAPIENS Androgen receptor network in prostate cancer FOXA1 ATF1 RB1 CRKL CCND1 CHEK2 MYC CHEK1 MAP2K1 SMARCC1 MAP2K2 SPINK1 SMARCC2 HGF TSC2 TSC1 CDC25B MSH6 MSH2 EIF4E1B ERG RAF1 FKBP5 BLM PRKDC PXN KLK3 RAP1A EIF4EBP1 BARD1 SMAD2 JUN PLK1 SMARCA4 CDC2 RHEB CDK4 SP1 NOXA1 CDK2 BCL2 MDM2 GRB2 ATM F13B ATR CDKN1A CDKN1B PTEN BRCA1 RPTOR CASP9 CASP8 CASP3 HRAS JAK1 MAP4K1 ACTL6B ACTL6A FOS ARID1A ETV4 ARID1B PIK3CA RAPGEF1 SOS1 CRK DOCK1 SMARCD1 SMARCD2 SMARCD3 HSD17B3 HSD17B4 HSD17B7 CYP17A1 CPN1 MAPK8 PAK1 HSD17B1 HSD17B2 MAPK1 PTK2B RICTOR MAPK3 CDKN2B HSD3B2 BAD STAT1 CDKN2A STAT3 HSD3B1 MRE11A PTPN11 MAPK14 MTOR RAD50 BAX SPRY2 SPRY1 MAJOR RECEPTORS TARGETED BY EPINEPHRINE AND NOREPINEPHRINE%WIKIPATHWAYS_20260610%WP4589%HOMO SAPIENS Major receptors targeted by epinephrine and norepinephrine ADCY3 ADRA1D ADRB1 ADCY1 ADRB2 ADCY8 ADRA2C ADRA2B ADCY6 ADRA2A ADCY5 HEL-S-7a ADCY9 ANGIOGENESIS%WIKIPATHWAYS_20260610%WP1539%HOMO SAPIENS Angiogenesis PLCG1 MAPK14 FGFR2 PIK3CA PDGFRA MAPK1 SMAD1 CREBBP FLT1 ANGPT1 SRC FGF2 HIF1A MMP9 VEGFA KDR TIMP3 BENZO A PYRENE METABOLISM%WIKIPATHWAYS_20260610%WP696%HOMO SAPIENS Benzo a pyrene metabolism HEL-S-165mP AKR1C1 EPHX1 CYP1A1 CYP1B1 AKR1C2 AKR1C4 CYP3A4 CONVERSION OF ANGIOTENSINOGEN TO ANGIOTENSIN II %WIKIPATHWAYS_20260610%WP4818%HOMO SAPIENS Conversion of angiotensinogen to angiotensin II HEL-S-130P CMA1 CTSG REN FGF23 SIGNALING IN HYPOPHOSPHATEMIC RICKETS AND RELATED DISORDERS%WIKIPATHWAYS_20260610%WP4790%HOMO SAPIENS FGF23 signaling in hypophosphatemic rickets and related disorders FGFR3 FGFR2 CCND1 SLC34A3 KL GALNT3 PTH CDKN1A SLC34A1 DMP1 opn NFKB1 NFKB2 CYP27B1 CYP24A1 CYP11B2 FAM20C ALPL ORAI1 ENPP1 FGF23 ROS1 DEVELOPMENT OF URETERIC DERIVED COLLECTING SYSTEM%WIKIPATHWAYS_20260610%WP5053%HOMO SAPIENS Development of ureteric derived collecting system ANOS1 ETV4 RARB FREM1 FREM2 BMPR1A CCND1 RET BMPR2 SIX1 HOXD11 CELSR1 GLI3 SPRY1 HOXA11 GRIP1 SHH SALL1 BMPER SIX2 GPC3 GDF11 TGFB1 EYA1 FST CRIM1 BMP7 DCN SMAD1 ETV5 PAX2 NR1B3 BMP5 BMP4 CTDNEP1 BMP2 FRAS1 GDNF SMO RARA SEROTONIN RECEPTOR 4 6 7 AND NR3C SIGNALING%WIKIPATHWAYS_20260610%WP734%HOMO SAPIENS Serotonin receptor 4 6 7 and NR3C signaling ATF1 EGR1 NR3C1 HTR4 HTR6 HTR7 CREB1 RPS6KA5 MAP2K1 MAPKAPK2 GNAS MAP2K2 MAPK1 MAPK3 RAP1A MICRORNA FOR TARGETING CANCER GROWTH AND VASCULARIZATION IN GLIOBLASTOMA%WIKIPATHWAYS_20260610%WP3593%HOMO SAPIENS MicroRNA for targeting cancer growth and vascularization in glioblastoma HES1 HIF1AN HIF1A VEGFA VEGFB VEGFC SARS COV 2 INNATE IMMUNITY EVASION AND CELL SPECIFIC IMMUNE RESPONSE%WIKIPATHWAYS_20260610%WP5039%HOMO SAPIENS SARS CoV 2 innate immunity evasion and cell specific immune response CXCL6 CXCL9 IFITM1 CSF2 CXCL8 TRADD CXCL17 CXCL1 CXCL13 CXCL3 STAT1 CXCL2 TNF CXCL5 IFIT2 TBK1 AP1G1 DHX58 TRIM25 EP300 IL6R HAVCR2 IL10 IFNAR2 TRAF2 ACE2 IRF3 hEMMPRIN TRAF3 TRAF6 TRAF5 IRF7 TLR7 NUP98 IFNAR1 HDAC2 TANK IL8RB LARP1 CCL5 CCL4 CCL3 CCL2 RIPK1 FADD RAE1 TFAP2A IFNB1 CD160 STAT2 MX1 PPBP MAVS IL6 CXCL11 TP53I3 CXCL12 RIGI PF4 NFKB1 TGFB1 CASP8 JAK1 2Q37 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260610%WP5224%HOMO SAPIENS 2q37 copy number variation syndrome HES1 TNF TRAF3 CXCL11 CXCL12 MROH2A UGT1A10 DGKD TRAF3IP1 NDUFA10 HJURP ERFE KLHL30 IL13RA1 GABARAPL2 HES6 MEF2C GABARAPL1 RPS6 EEF1A1 THAP4 RRAGA RRAGB RRAGD CALCA CALCRL TWIST2 AGAP1 PDGFA JUN GABARAP NEU4 OR6B3 MAP4 TRPM8 OR6B2 ABCA1 UBE2F MTERF4 RAB27A NFKBIA CALM1 COPS8 HAMP COPS9 SNED1 RTP5 ARF1 RNPEPL1 ITGB3 PRL ING5 GYS1 SEPT6 MAP1LC3A MAP1LC3C RAC1 KIF1A GAL3ST2 ILKAP BOK MYOG UGT1A1 AQP12B AQP12A ITPK1 DUSP28 ANO7 OTOS HEL-S-28 ARL4C MYOD1 IL1B DKFZp762B153 IRF8 USP40 AGXT ARF5 DTYMK CXCR4 NEDD8 ASCL1 ASB18 CENPA EGFR CYTH2 GBX2 PPP1R7 GPC1 SH3BP4 UGT1A4 SPP2 UGT1A3 D2HGDH PRLH DISC1 UGT1A9 UGT1A8 ANKMY1 CYTH1 UGT1A7 FARP2 SEPTIN2 PDX1 SEPTIN4 PER2 MLPH CAPN10 ACKR3 PDCD1 RAB17 RAMP1 ASB1 LEUKOTRIENE METABOLIC PATHWAY%WIKIPATHWAYS_20260610%WP5171%HOMO SAPIENS Leukotriene metabolic pathway ABCC1 ALOX5 CYP4F3 ALOX5AP DPEP2 LTC4S PTGR1 DECR2 DECR1 SEROTONIN AND ANXIETY%WIKIPATHWAYS_20260610%WP3947%HOMO SAPIENS Serotonin and anxiety PRKCB FMR1 PLEK HTR1A HTR2A TRPV1 ADRA1A POMC PPP3CA ARC EEF2K CRH PLCD4 FOS PI3K AKT MTOR SIGNALING AND THERAPEUTIC OPPORTUNITIES IN PROSTATE CANCER%WIKIPATHWAYS_20260610%WP3844%HOMO SAPIENS PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer PIK3CA GSK3B MAPKAP1 PIK3R3 PIK3R2 FOXO4 PIK3R1 TSC2 FOXO1 NRAS RB1CC1 GRB10 RICTOR MLST8 FOXO3A TFEB BAD ULK1 EIF4EBP1 MTOR RHEB CDKN1B PTEN RPTOR HRAS PANCREATIC CANCER SUBTYPES%WIKIPATHWAYS_20260610%WP5390%HOMO SAPIENS Pancreatic cancer subtypes CLRN3 CDH17 SPRR1B SPRR3 ST6GALNAC1 HEL-S-116 GPR87 HEL136 KRT20 CST6 AREG CYP3A7 LGALS4 SCEL TSPAN8 VSIG2 AGR3 FAM3D TNS4 KRT6C FAM83A KRT6A SERPINB3 BTNL8 FGFBP1 S100A2 REG4 KRT7 ANXA10 LYZ LEMD1 DHRS9 CEACAM6 SCCA2 PLA2G10 LY6D TFF3 TFF2 TFF1 VGLL1 NOTCH1 REGULATION OF ENDOTHELIAL CELL CALCIFICATION%WIKIPATHWAYS_20260610%WP3413%HOMO SAPIENS NOTCH1 regulation of endothelial cell calcification FGFR3 JAG2 NOTCH1 ITGA1 LPAR1 PLAT DLL3 DLL4 GJA5 MGP CALU SOX6 ALPL VEGFA MIR 124 PREDICTED INTERACTIONS WITH CELL CYCLE AND DIFFERENTIATION %WIKIPATHWAYS_20260610%WP3595%HOMO SAPIENS mir 124 predicted interactions with cell cycle and differentiation PRKAA1 SIX4 CTDSP1 STRADB PTBP1 STK11 MIR 222 IN EXERCISE INDUCED CARDIAC GROWTH%WIKIPATHWAYS_20260610%WP3938%HOMO SAPIENS miR 222 in exercise induced cardiac growth CDKN1B HMBOX1 HIPK1 HIPK2 FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20260610%WP357%HOMO SAPIENS Fatty acid biosynthesis ACACB ACACA ACLY PC SCD FASN ECHDC1 ECHDC2 PECR ECHS1 MECR ACSS2 ACSL1 ACSL6 FACL4 ACSL5 ACSL3 DECR1 INTERFERON TYPE I SIGNALING%WIKIPATHWAYS_20260610%WP585%HOMO SAPIENS Interferon type I signaling RAPGEF1 CRK CREB1 RPS6KA5 STAT1 STAT3 PTPN11 MAPK14 MTOR EIF4A1 IFNAR2 IRS1 PIK3CD RPS6KA4 MAP2K3 PRMT1 TYK2 GAB2 VAV1 PIAS1 ZAP70 LCK IFNAR1 IRF9 CBL SOCS3 SOCS1 STAT4 FYN EIF4E EIF4B MAP2K6 MAP3K1 PTPRC RPS6KB1 REL PTPN6 STAT2 CRKL MAPKAP1 PIK3R2 PIK3R1 MLST8 RPS6 RAP1A EIF4EBP1 RPTOR JAK1 RAC1 SARS COV 2 B 1 1 7 VARIANT ANTAGONISES INNATE IMMUNE ACTIVATION%WIKIPATHWAYS_20260610%WP5116%HOMO SAPIENS SARS CoV 2 B 1 1 7 variant antagonises innate immune activation TBK1 IFNB1 TOMM70 IKBKE MAVS RIGI IRF3 TRAF3 TRAF6 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES AUTOPHAGY%WIKIPATHWAYS_20260610%WP4863%HOMO SAPIENS Host pathogen interaction of human coronaviruses autophagy MTOR ATG3 PIK3R4 ATG10 WIPI1 ZFYVE1 ATG12 DKFZp686F0183 ATG16L2 ATG16L1 ULK2 RB1CC1 ULK1 MAP1LC3A DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260610%WP707%HOMO SAPIENS DNA damage response CREB1 MRE11A RAD50 BAX RB1 CCND1 CHEK2 MYC CHEK1 H2AX HUS1B BBC3 TP53AIP1 PIDD1 CCND3 CCND2 SESN1 TLK2 TLK1 NBN APAF1 RFC1 SMC1A DDB2 PRKDC CCNE2 RRM2B FANCD2 CCNE1 CCNB3 CCNB2 CCNB1 PMAIP1 SFN ATRIP CDC2 GADD45B GADD45A CDK4 TNFRSF10B PML GADD45G CDK2 RAD52 CDK6 MDM2 RAD51 CDK5 ATM CYCS RAD17 ATR CDKN1A RAD1 CDKN1B RAD9A BRCA1 CASP9 CASP8 CASP3 IL1 AND MEGAKARYOCYTES IN OBESITY%WIKIPATHWAYS_20260610%WP2865%HOMO SAPIENS IL1 and megakaryocytes in obesity S100A9 MYD88 CCR3 PIK3CA HBEGF IL1B IL1R1 F2R NFKB1 HEL-S-134P IL18 F2 PLA2G7 TLR1 IRAK1 CCL2 MMP9 IFNG FCER1A NLRP3 TIMP1 EV RELEASE FROM CARDIAC CELLS AND THEIR FUNCTIONAL EFFECTS%WIKIPATHWAYS_20260610%WP3297%HOMO SAPIENS EV release from cardiac cells and their functional effects ERBB4 RGS16 MYB KLF2 PRL CXCL12 PREGNANE X RECEPTOR PATHWAY%WIKIPATHWAYS_20260610%WP2876%HOMO SAPIENS Pregnane X receptor pathway UGT1A4 UGT1A3 CYP3A7 UGT1A1 UGT1A9 ABCC3 NCOA1 CYP3A4 ABCC2 ABCB1 NR1i2 CYP2C19 CYP4F12 CYP2C9 SLCO1B1 CYP2A6 RXRA FOXO1 CYP2B6 SRPX2 DNAJC7 PPARGC1A SULT2A1 SRC ACUTE MYELOID LEUKEMIA%WIKIPATHWAYS_20260610%WP5293%HOMO SAPIENS Acute myeloid leukemia PIK3CA SOS1 MAPK1 CSF2 MAPK3 ITGAM SPI1 FLT3 BAD ARAF MPO NR1C2 STAT3 IKBKB AKT3 PIM1 PIM2 IKBKG MTOR CHUK RUNX1 CCNA2 KIT SOS2 CEBPA CSF1R PIK3CD BCL2A1 CEBPE LEF1 RELA CD14 FCGR1A PER2 RUNX1T1 STAT5B TCF7L2 TCF7L1 JUP ZBTB16 IL3 RPS6KB2 RPS6KB1 CCND1 MYC MAP2K1 MAP2K2 PIK3R3 PIK3R2 PIK3R1 NRAS NFKB1 RAF1 EIF4EBP1 PML GRB2 HRAS RARA CREATINE PATHWAY%WIKIPATHWAYS_20260610%WP5190%HOMO SAPIENS Creatine pathway SLC6A8 HEL-S-20 HEL-S-29 GLIOBLASTOMA SIGNALING%WIKIPATHWAYS_20260610%WP2261%HOMO SAPIENS Glioblastoma signaling PIK3CA MAPK1 MAPK3 CDKN2B EGFR ARAF CDKN2A AKT3 EP300 SPRY2 IRS1 PIK3CD MAP2K3 PDGFRA CBL SRC PIK3C2G BRCA2 MAP2K6 IGF1R PIK3C2B DKFZp781B1423 MAP2K4 PRKCB PLCG1 PRKCI FGFR2 PRKCH PDPK1 PRKCA PRKCQ RB1 PRKCZ ERBB3 CCND1 ERBB2 PLCG2 MAP2K5 CDKN2C MAP2K1 NF1 FGFR1 MAP2K2 PIK3R2 FOXO4 TSC2 PIK3R1 TSC1 FOXO1 CCND2 NRAS MSH6 FOXO3A RAF1 CCNE1 CDK4 CDK2 CDK6 MDM2 GRB2 ATM CDKN1A CDKN1B PTEN BRCA1 HRAS ETHANOL METABOLISM PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20260610%WP4269%HOMO SAPIENS Ethanol metabolism production of ROS by CYP2E1 MAPK8 MAFK CYP2E1 NFE2L2 SP1 MAP2K1 MAP2K2 MAFG MAFF TRANSCRIPTION FACTOR REGULATION IN ADIPOGENESIS%WIKIPATHWAYS_20260610%WP3599%HOMO SAPIENS Transcription factor regulation in adipogenesis NR3C1 IL6 CEBPA IRS1 CREB1 MAPK8 RXRA CEBPB FOXO1 CEBPD INSR TWIST1 PPARGC1A SLC2A4 LEP PPARG LPIN1 PCK2 TNF PURINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260610%WP4224%HOMO SAPIENS Purine metabolism and related disorders AMPD1 PFAS PAICS APRT DGUOK PNP IMPDH1 AOX1 XDH ADSS ADA ADSL TPMT HEL-S-70p RRM2B MOCOS FAS LIGAND PATHWAY AND STRESS INDUCTION OF HEAT SHOCK PROTEINS%WIKIPATHWAYS_20260610%WP314%HOMO SAPIENS Fas ligand pathway and stress induction of heat shock proteins MAP2K4 RB1 MAPKAPK2 MAPK8 PAK1 APAF1 PRKDC TNF JUN FAF1 LMNB2 BCL2 ACTG1 CASP6 PS1TP5BP1 CASP10 CYCS ARHGDIB LMNA MAP3K7 SPTAN1 HEL-S-102 DFFB CASP9 DFFA CASP8 RIPK2 CASP3 ACTA1 IL1A TNFSF6 MAPKAPK3 FADD MAP3K1 NFX1 SMIM40 APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20260610%WP384%HOMO SAPIENS Apoptosis modulation by HSP70 MAPK10 AIFM1 CASP2 CASP6 CYCS NFKB1 CASP9 CASP8 APAF1 CASP3 TNFSF6 RIPK1 MAP3K1 FADD TNFRSF1A ALBUTEROL AND BUDESONIDE THERAPY FOR ASTHMA%WIKIPATHWAYS_20260610%WP5503%HOMO SAPIENS Albuterol and budesonide therapy for asthma MYL4 PLCB3 PLCB4 NR3C1 PRKAR1B ADCY3 MYL1 PRKAR1A MYL2 ADCY1 CREB1 MYL3 ADRB2 PLCB1 ADCY8 PLCB2 GNAS ADCY6 ADCY5 ADCY9 VEDOLIZUMAB THERAPY FOR INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260610%WP5512%HOMO SAPIENS Vedolizumab therapy for inflammatory bowel disease ITGA4 ITGA2 MADCAM1 ITGB7 SELE ITGB1 SELPLG VCAM1 HISTONE MODIFICATIONS%WIKIPATHWAYS_20260610%WP2369%HOMO SAPIENS Histone modifications KMT2E SETD4 SUV39H2 SETD5 SETD2 SET SETD3 KMT2A SETD8 SMYD5 SETD9 SUV39H1 KMT2C SETD6 KMT2B DOT1L SETD7 EHMT1 PRDM2 H3C15 SMYD2 SMYD1 KMT5B SMYD4 SMYD3 H3C8 H4C7 MLL2 H4C9 H3F3B SETDB1 KMT5C EED HIST1H4L SETD1B SETD1A SETDB2 SETMAR ASH1L AEBP2 SETBP1 EZH1 EZH2 ANGIOPOIETIN LIKE PROTEIN 8 REGULATORY PATHWAY%WIKIPATHWAYS_20260610%WP3915%HOMO SAPIENS Angiopoietin like protein 8 regulatory pathway MAPK10 RPS6KA5 PRKAA1 SCD FASN IRS1 PIK3CD RPS6KA4 MAP2K3 CBL EIF4E MAP2K6 MAP3K1 RPS6KB1 IRS4 CBLC RPS6KA6 SESN3 RPS6KA2 RPS6KA1 PIK3R4 MAP3K8 MAP3K6 SLC16A2 MAP3K5 ABCG8 PRKAB2 MAP2K1 ABCG5 PRKAB1 MAP2K2 SHC2 SHC3 SHC1 LPL TSC2 PCK1 TSC1 G6PC1 MLXIPL MAP3K10 MAP3K13 MAP3K14 MAP3K11 RAF1 MAP3K12 GSK3A THRA HEL-S-31 PRKAG1 PRKAG2 PRKAG3 EIF4EBP1 FLOT1 FLOT2 CAP1 MAP4K2 EXOC7 MINK1 SREBF2 RHEB SLCO1C1 FBP1 PRKAA2 CYP7A1 INS NR1A2 MAPK9 MAPK7 MAPK6 MAPK4 MAP4K3 MAP3K2 PTPN1 HEL-S-42 NR1H3 RPTOR MAPK12 MAPK13 MAPK11 TRIP10 GYS1 HRAS MAP4K1 PIK3CA RAPGEF1 SOS1 CRK MAPK8 RXRA CYP2B6 MAPK1 RICTOR MAPK3 MAPK14 MTOR SOS2 RPS6KB2 PIK3C2G MAP2K4 PDPK1 CYP3A4 MAP2K5 GSK3B MAPKAP1 PIK3R3 PIK3R2 PIK3R1 FOXO1 INSR SLC2A4 MLST8 FOXO3A MAP3K7 CILIARY LANDSCAPE%WIKIPATHWAYS_20260610%WP4352%HOMO SAPIENS Ciliary landscape CAMK2A DYNLT2B USH1C HEL-S-47e RAB21 RMND5B IFT74 EXOSC4 DNPEP PGRMC2 RMND5A CBS STOM SNRPB2 UQCC NDUFA9 DYNC1H1 NDUFA5 RANBP9 LRPPRC MKLN1 WEE1 TTC8 PSMC6 ECHS1 GID4 MFAP1 APC RAB14 GLB1 PSMC4 VAPB ACSL3 XPNPEP3 GID8 RQCD1 DNCL1 YPEL5 CLUAP1 GLA H3F3B HDAC2 TFAP2A RB1 TRAF3IP1 MSH2 EXOC7 CALM1 COPS8 DYNC2I2 DGKE IFT172 UBE2D2 HEL113 RAC1 SMC4 DCAF7 PSMD7 MAEA APMAP CEP97 RAB2A IFT80 ARMC8 LZTFL1 DYNC1LI1 MYL6 IFT81 TIPRL ERF CD2BP2 ARL8B DDX5 POM121 PSMD12 CTBP2 INTU PSMD13 HTRA2 COPS7A IQGAP1 HEL-S-296 IQGAP3 CDH23 DVL3 NUP88 CDR2 AAR2 CTSA BBS2 NEK8 TFAP2B BBS1 TFAP2C UBE2H TFAP2D TFAP2E RHBDD2 EXOC6B CNOT10 FUZ BBIP1 LSM4 COPS4 IFT20 COPS6 IFT22 EHD3 COPS5 CNOT1 CREBBP WNK1 MKS1 LCN2 RANBP10 IFT27 DYNLRB2 IFT25 NEF3 DOCK5 TTC26 GDI1 MCM7 ZMYND19 MCM9 MCM10 MYL6B RPGR IFT52 NEFL BBS9 CEP170 TMED1 BBS7 IFT57 DFNB31 CEP290 NINL BBS5 SNAP29 BBS4 RAB8A NFKB1 IQCB1 EIF5B RBM14 NUDC CNOT6L EXOC8 NUP133 DYNLT1 EIPR1 IFT140 DYNLT3 RAB3IL1 ARFGAP3 DYNLL2 IFT43 RABEP2 TBC1D4 NME8 MCM3 EXOC4 EXOC3 EXOC6 MCM5 MCM6 EXOC5 EFHC2 IFT46 MAPRE2 EXOC2 PAFAH1B1 MCM2 CCDC40 EXOC1 YAP1 IFT70B IFT70A RALB WDR26 HEL-S-91n HDAC1 SSNA1 ANKS3 VPS4A GABA AND GLUTAMATE SIGNALLING IN EPILEPTOGENESIS%WIKIPATHWAYS_20260610%WP5600%HOMO SAPIENS GABA and glutamate signalling in epileptogenesis CAMK2A PLCB1 HDAC10 FRMPD3 CRTC1 ABAT ADARB1 CDH2 PIG59 HEL-S-162eP SH3GL2 PDIA2 SLC6A13 SLC6A12 SLC6A11 GABRG3 GABRG1 STIM1 GRIA2 SLC1A1 SLC1A2 SLC1A3 EFNB2 SDCBP GRIA3 GRIA4 HOMER1 NETO2 GRIN2B GRIN3B GRIN3A DLG4 CPEB3 GABRB3 GABRB2 GABRB1 GRIK5 GRIK3 GRIK1 AP2A1 MAP2K1 SLC7A11 GRIK2 AP2A2 CABIN1 GABRR3 GRM3 GRM2 GABRR1 SUMO1 GRM6 GRM8 NPTN FFAR1 DLGAP3 SLC32A1 NRG1 C1QL3 C1QL2 PICK1 GLS2 NRXN3 PPP2CA CACNG8 NWD1 SNX27 GNA11 CACNG2 GABRE ATAD1 GABRQ GABRA2 GABRP MBD5 SLC12A5 GABRA6 GABRA5 GAD1 GABRA4 GABRA3 SYVN1 LHFPL4 GRIN1 SNX14 ERBB4 DKFZp762B153 MAPK1 MAPK3 STAT1 STAT3 CREBBP SLC6A8 SRC PRKCA ARC ORAI1 GRIP1 HDAC1 PRION DISEASE PATHWAY%WIKIPATHWAYS_20260610%WP3995%HOMO SAPIENS Prion disease pathway TBP HEL-S-269 PAX5 POU2F2 BATF IRF4 RFX5 CREB1 FGFR1 RXRA MAPK1 NFKB1 MAPK3 MEF2C SPI1 STAT3 EP300 BCL2 CTCF CHD2 SMC3 CASP3 FYN HEL-S-125m HEL-S-89n CASP12 RAD21 NCAM1 PRNP NEURODEGENERATION WITH BRAIN IRON ACCUMULATION NBIA SUBTYPES PATHWAY%WIKIPATHWAYS_20260610%WP4577%HOMO SAPIENS Neurodegeneration with brain iron accumulation NBIA subtypes pathway ATG3 PIK3R4 ATG10 PANK2 WIPI1 PLA2G6 WDR45 ATG12 DCAF17 DKFZp686F0183 SPTLC1 DEPTOR ATG16L1 ATG101 WIPI2 STK11 C19orf12 PRKAA1 ATG14 CP TSC2 COASY TSC1 FA2H AKT1S1 RB1CC1 ATG2A FTL MLST8 ULK1 ACACA MTOR RHEB RPTOR MAP1LC3A CELL TYPE DEPENDENT SELECTIVITY OF CCK2R SIGNALING%WIKIPATHWAYS_20260610%WP3679%HOMO SAPIENS Cell type dependent selectivity of CCK2R signaling RYR1 RYR2 DAGLA CCKBR CNR1 PLCB1 TRPC1 CCK RYR3 GNAI1 SPHINGOLIPID METABOLISM IN SENESCENCE%WIKIPATHWAYS_20260610%WP5121%HOMO SAPIENS Sphingolipid metabolism in senescence PRKCB SPHK1 SGMS2 SGPP1 MTOR UGCG PRKCA TERT S1PR1 RB1 DEGS1 S1PR2 CDK4 KDSR S1PR5 RPP38 SPTLC1 CDK2 PLCB1 CERS2 CDKN1A MAPK1 GLB1 METHYLATION PATHWAYS%WIKIPATHWAYS_20260610%WP704%HOMO SAPIENS Methylation pathways PNMT NNMT TPMT MAT1A INMT MELATONIN METABOLISM AND EFFECTS%WIKIPATHWAYS_20260610%WP3298%HOMO SAPIENS Melatonin metabolism and effects CAMK2A CYP1A2 CRY2 CRY1 PRKCA CYP1A1 CYP1B1 GSK3B CYP2C19 FOXO1 NFKB1 ADRB1 TRAF6 PER2 CALM1 ACHE MAOA ASMT ECE1 hCG_2014051 SULT1A1 AANAT MAP2 APOE EDN1 CSNK1D IRAK1 SIRT1 PER1 MTNR1A PER3 MTNR1B GUT LIVER INDOLE METABOLISM %WIKIPATHWAYS_20260610%WP3627%HOMO SAPIENS Gut liver indole metabolism CYP2E1 METABOLISM OF TETRAHYDROCANNABINOL THC %WIKIPATHWAYS_20260610%WP4174%HOMO SAPIENS Metabolism of tetrahydrocannabinol THC CYP3A4 CYP2C9 GLYCINE METABOLISM%WIKIPATHWAYS_20260610%WP1495%HOMO SAPIENS Glycine metabolism SHMT1 HEL-S-51e BLADDER CANCER%WIKIPATHWAYS_20260610%WP2828%HOMO SAPIENS Bladder cancer HBEGF THBS1 RB1 TYMP RASSF1 CCND1 ERBB2 EGF MMP2 MYC DAPK2 RPS6KA5 UPK3A MAP2K1 MAP2K2 PIK3R2 PIK3R1 NRAS MAPK1 CXCL8 RAF1 EGFR ARAF CDKN2A FGFR3 CDK4 MDM2 CDKN1A SRC HRAS MMP9 VEGFA EXTRACELLULAR VESICLES IN THE CROSSTALK OF CARDIAC CELLS%WIKIPATHWAYS_20260610%WP4300%HOMO SAPIENS Extracellular vesicles in the crosstalk of cardiac cells IL6 EGF CD63 CD81 GATA4 HEL-S-44 IGF1 ETS2 BIRC5 TLR4 PTEN opn HEL-S-102 EGFR MMP9 STAT3 KDR STRIATED MUSCLE CONTRACTION PATHWAY%WIKIPATHWAYS_20260610%WP383%HOMO SAPIENS Striated muscle contraction pathway MYL4 MYL1 MYL2 MYL3 MYOM1 HEL-S-273 TTN TNNI1 TNNI2 TNNI3 DMD HEL-S-108 MYBPC3 TMOD1 ACTN2 TPM3 TNNC1 TPM1 TNNC2 ACTN4 ACTA2 DES TNNT1 TNNT3 MYH8 TCAP MYH6 ACTG1 ACTA1 HEL113 MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20260610%WP391%HOMO SAPIENS Mitochondrial gene expression PPP3CA SP1 CREB1 ESRRA MYEF2 MTERF3 TFB2M NRF1 GABPB1 TFB1M POLRMT PPRC1 HCFC1 CAMK4 TFAM PPARGC1A MTERF1 PPARGC1B GABPA ASPIRIN AND MIRNAS%WIKIPATHWAYS_20260610%WP4707%HOMO SAPIENS Aspirin and miRNAs NFKB1 NR1C1 MVD PTGS2 WNT1 VEGFA PTGS1 PYRIMIDINE METABOLISM%WIKIPATHWAYS_20260610%WP4022%HOMO SAPIENS Pyrimidine metabolism DPYS ENPP3 HEL74 TK1 POLE ENTPD1 ENTPD3 CAD NME2 NME3 CTPS2 NME4 DCTD NME6 NME7 POLR1A DPYD POLR1C CMPK1 POLR1D CMPK2 DTYMK POLR1F UPRT UMPS POLR1H DCTPP1 PRIM2 PRIM1 TYMS POLD3 POLD4 POLR2A POLR2B POLR2C POLR2D POLD2 POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POLR2J3 RRM1 DUT RRM2 PNPT1 POLR2J2 POLR3GL DHODH POLE4 POLA1 UCK2 POLA2 UCK1 POLR3A POLR3B POLR3C POLE2 POLR3D POLE3 POLR3E POLR3F POLR3G POLR3H POLR3K TYMP ENPP1 RRM2B CDA TRANS SULFURATION PATHWAY%WIKIPATHWAYS_20260610%WP2333%HOMO SAPIENS Trans sulfuration pathway pcap CTH MTR GCLM CBS INFLUENZA A VIRUS INFECTION%WIKIPATHWAYS_20260610%WP1438%HOMO SAPIENS Influenza A virus infection BCL2 ULTRACONSERVED REGION 339 MODULATION OF TUMOR SUPPRESSOR MICRORNAS IN CANCER%WIKIPATHWAYS_20260610%WP4284%HOMO SAPIENS Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer CCNE2 INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260610%WP5120%HOMO SAPIENS Inclusion body myositis NFKB1 PSENEN NFKB2 BACE1 APP MSTN PSEN2 PSEN1 SIRT1 EBOLA VIRUS INFECTION IN HOST%WIKIPATHWAYS_20260610%WP4217%HOMO SAPIENS Ebola virus infection in host ITGA1 ITGB1 ITGA4 ITGA2 TBK1 EP300 HAVCR2 PIK3CD IRF3 IRF7 SOCS3 TFAP2A REL IKBKE RIGI CLEC4M CLEC10A ICAM2 ICAM3 HLA-DOA HLA-DOB VPS39 KPNA1 VPS18 CD300A VPS33A ACTN1 HLA-B HLA-C TIMD4 RFC1 HLA-A HLA-F HLA-G HLA-E TIAM1 ADAM17 TYRO3 TSG101 SCIN CLTCL1 HLA-DQA2 HLA-DQA1 VPS16 HLA-DRB5 CAV3 CAV2 EIF2AK2 EIF2S1 BST2 IL4 CD209 CLEC6A RAB5A HLA-DRB1 CLTC CLTB CLTA ASGR1 ITGB3 CTSL C1QBP ITGAV HAVCR1 MBL2 HLA-DPA1 RHOB RAC1 VAV2 NPC1 NPC2 RASA2 ITGA6 PIK3CA MFGE8 HLA-DQB2 RAB7A HLA-DQB1 RELB CDC42 HLA-DMA HLA-DMB FLNA FLNB DAB2IP MERTK ARHA AXL PAK1 NEDD4 VPS41 HLA-DPB1 MAPK1 RAB9A FOLR1 MAPK3 IQGAP1 EGFR STAT1 RELA CREBBP IGF1R PIK3R3 PIK3R2 PIK3R1 TLR4 NFKB1 NFKB2 ACTN4 ACTG1 PS1TP5BP1 VPS4A FATTY ACID TRANSPORTERS%WIKIPATHWAYS_20260610%WP5061%HOMO SAPIENS Fatty acid transporters HEL-S-104 FABP9 DBI FABP1 FABP2 ACSL1 FABP5 ACSL6 FABP6 FACL4 CD36 ACSL5 SLC27A4 ACSL3 MAPK CASCADE%WIKIPATHWAYS_20260610%WP422%HOMO SAPIENS MAPK cascade MAP2K4 MAPK10 PLCB3 SOS1 MAP2K1 MAP2K2 NRAS MAPK1 MAPK3 RAF1 MAP3K12 ARAF RRAS MBP MAPK14 RASA3 LAMTOR3 JUN SIPA1 SOS2 MAP2K3 GRB2 MAP3K2 MAPK12 MAP2 HRAS MAP2K6 MAP3K1 FOCAL ADHESION%WIKIPATHWAYS_20260610%WP306%HOMO SAPIENS Focal adhesion MAPK10 ITGA1 MYL2 ITGB1 VEGFB VEGFC ITGA4 ITGA2 ITGB7 PIK3CD VAV1 FYN CRKL CCND1 MAP2K1 SHC2 SHC3 SHC1 HGF CCND3 CCND2 ACTN1 RAF1 PXN RAP1A PDGFA JUN CAV3 CAV2 BCL2 MAPK9 GRB2 PTEN ITGB3 ITGAV HRAS RAC1 VAV2 ITGA6 PIK3CA RAPGEF1 SOS1 CRK DOCK1 CDC42 HEL-S-28 FLNA FLNB ARHA MAPK8 PAK1 MAPK1 MAPK3 EGFR BAD AKT3 MYLK2 ITGA2B TNC HEL114 sm-M20 ARHGAP35 MYLK3 MYLK MYLK4 COMP PPP1CC IBSP TNR HEL-S-80p MYL11 MYL5 PDGFRA MYL7 COL4A2 COL4A1 COL4A4 FLT1 COL4A6 TLN2 SRC TLN1 BLK SHC4 IGF1R TXK VEGFA KDR MYL12A MYL12B PRKCB VTN PDGFD CHAD PDGFC PDPK1 PRKCA MYL10 PIP5K1C THBS1 VASP SRMS TNK2 ERBB2 EGF TNK1 PTK6 PARVA PARVB COL1A1 GSK3B COL1A2 PIK3R3 PARVG PIK3R2 IGF1 COL5A3 COL5A2 PIK3R1 ITGB4 RASGRF1 LAMC2 opn LAMC1 ARHGAP5 ITGB8 RAC3 ITGB6 VAV3 VWF EMP2 COL2A1 ITGA7 PPP1R12C BIRC2 BIRC3 LAMA5 ACTN4 ROCK1 LAMA1 ROCK2 LAMA4 LAMA3 THBS2 THBS4 THBS3 RELN PAK6 ACTG1 PAK4 LAMB3 PS1TP5BP1 LAMB2 STYK1 LAMB1 VEGFD XB c-fgr ZYX NUCLEOTIDE GPCRS%WIKIPATHWAYS_20260610%WP80%HOMO SAPIENS Nucleotide GPCRs P2RY6 P2RY4 ADORA2A ADORA2B P2RY2 P2RY1 LPAR4 LTB4R OSTEOBLAST SIGNALING%WIKIPATHWAYS_20260610%WP322%HOMO SAPIENS Osteoblast signaling TNFRSF11B PTH PTH1R SLC17A2 PDGFRA ITGB3 ITGAV COL1A1 BGLAP FGF23 IBSP TNFSF11 MIRNA DEGRADING ENZYMES%WIKIPATHWAYS_20260610%WP4316%HOMO SAPIENS miRNA degrading enzymes XRN1 EXOSC4 PNPT1 17P13 3 YWHAE COPY NUMBER VARIATION%WIKIPATHWAYS_20260610%WP5376%HOMO SAPIENS 17p13 3 YWHAE copy number variation PPP2CA DCTN6 HEL-S-93 DISC1 DCTN5 HEL2 DDC DCTN1 DCTN4 DCTN3 DBH HEL-S-77 YWHAQ CDK5 TH DYNC1H1 HEL-S-1 YWHAG PAFAH1B1 NDEL1 2Q13 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260610%WP5222%HOMO SAPIENS 2q13 copy number variation syndrome IL1B MERTK POLR1A POLR1C CHTM1 POLR1D IL1RN MAPK1 CSF2 CSF1 POLR1F ZC3H8 IL36A IL36B POLR1H PSD4 CXCL13 ARL14 CKAP2L STAT1 IL23A POLR1G ANAPC1 ARF6 FBLN7 TMEM87B SLC20A1 RGPD8 GATA3 TULP1 POLR2H TTL IL1RL2 BCL2L11 POLR2K NT5DC4 POLR2L POLR2F IL36RN IL37 IL36G IL2 IL1F10 SOCS3 SOCS1 IL6 PLCG2 GRB2 IL1R1 IL1A RAC1 DISORDERS OF FOLATE METABOLISM AND TRANSPORT%WIKIPATHWAYS_20260610%WP4259%HOMO SAPIENS Disorders of folate metabolism and transport SHMT1 MTR HEL-S-51e SLC46A1 MTHFS FTCD DHFR MTHFD1 MTHFD2 FOLR1 MTHFD2L SLC19A1 TYMS HEL-S-70p METABOLIC REPROGRAMMING IN COLON CANCER%WIKIPATHWAYS_20260610%WP4290%HOMO SAPIENS Metabolic reprogramming in colon cancer PDHA1 MDH2 HEL107 PGAM1 HEL-S-51e GOT2 HEL-S-133P PYCR2 HEL-S-68p SDHB RPIA GLUD1 PFKL PSAT1 SUCLG2 ACO2 ALDOB PAICS ACLY FASN HEL-S-162eP FH HEL-S-30 ENO1 GLS HK3 SLC16A3 PSPH TIGAR IRON SULFUR CLUSTER BIOGENESIS%WIKIPATHWAYS_20260610%WP5152%HOMO SAPIENS Iron sulfur cluster biogenesis NFU1 NARF LYRM4 ABCB7 FDX1 FDXR HSCB CIAO2B FXN ISCU NUBP1 NUBP2 KCNQ2 AND KCNQ3 RELATED EPILEPSY%WIKIPATHWAYS_20260610%WP5599%HOMO SAPIENS KCNQ2 and KCNQ3 related epilepsy CAMK2A BACE1 NEDD4 SNAP25 RAB1A AKAP5 DAG1 ZNF547 TRAPPC3 PRRT2 PRKCE RAB11A GIGYF1 TRAPPC6B SCN8A KCNQ2 KCNQ3 KCNQ5 FGF13 SCN2A SCN4B FGF12 CALM1 VAMP2 STX1A NEURAL CREST CELL MIGRATION DURING DEVELOPMENT%WIKIPATHWAYS_20260610%WP4564%HOMO SAPIENS Neural crest cell migration during development PIK3CA PIK3R4 MMP2 PIK3R3 ARHA PAK1 TWIST1 STAT3 AKT3 TIAM1 JUN PIK3CD PAK6 PAK4 EPHB6 TRIO PIK3R5 EPHB2 ARF1 EPHB1 EPHB4 EPHB3 NGFR BDNF CDH11 F2RL2 MMP9 RAC1 FOS TCA CYCLE IN SENESCENCE%WIKIPATHWAYS_20260610%WP5050%HOMO SAPIENS TCA cycle in senescence PDHA1 FH PDP2 HEL-S-32 ME1 ME2 RETT SYNDROME%WIKIPATHWAYS_20260610%WP4312%HOMO SAPIENS Rett syndrome HDAC5 GRIN2B KDM5B TRRAP STXBP1 FOXG1 HTT GPS2 CRK CHD4 HDAC8 SYNE2 RHOBTB2 CECR2 SYNGAP1 TAF1B TBL1X HIVEP2 SCN1A SRRM3 GABBR2 EIF2B2 CDKL5 KCNJ10 SMARCA1 MEF2C NCOR2 GNAO1 XAB2 NCOR1 SMC1A TBL1XR1 IMPDH2 TCF4 HAP1 SHANK3 SMARCA4 SCN8A SCN2A GABRA3 HDAC1 ACTL6B BEMPEDOIC ACID THERAPY IN ATHEROSCLEROSIS AND METABOLIC SYNDROME%WIKIPATHWAYS_20260610%WP5500%HOMO SAPIENS Bempedoic acid therapy in atherosclerosis and metabolic syndrome MAPK10 PRKAB2 PRKAB1 PRKAA1 MAPK8 G6PC1 MAPK1 MAPK3 PCK2 PRKAG1 PRKAG2 PRKAG3 CRP ACACB ACACA HMGA1 MAPK14 ACLY G6PC2 G6PC3 SLC27A2 PRKAA2 MAPK9 MAPK12 MAPK13 MAPK11 GENES TARGETED BY MIRNAS IN ADIPOCYTES%WIKIPATHWAYS_20260610%WP1992%HOMO SAPIENS Genes targeted by miRNAs in adipocytes IGF1 HCN4 KCNE1 GJA1 TMSB4X ERG HAND2 KCNJ2 HCN2 COPPER HOMEOSTASIS%WIKIPATHWAYS_20260610%WP3286%HOMO SAPIENS Copper homeostasis ADAM9 MT1B XAF1 PIK3CA STEAP1 STEAP2 MT1E BACE1 APP CCND1 GSK3B HEL-S-44 FOXO1 FOXO3A APC ADAM17 JUN SP1 STEAP3 STEAP4 MDM2 COX17 ATP7B COX11 ATP7A SLC31A2 SLC31A1 PTEN SLC11A2 ADAM10 COMMD1 MT4 MT3 CASP3 ATOX1 CCS MT1A SCO1 MTF1 MT1F PRNP MT1G ALANINE AND ASPARTATE METABOLISM%WIKIPATHWAYS_20260610%WP106%HOMO SAPIENS Alanine and aspartate metabolism GAD1 AGXT PC GOT2 GAD2 ASL GPT ABAT ASPA ASS1 GPCRS CLASS B SECRETIN LIKE%WIKIPATHWAYS_20260610%WP334%HOMO SAPIENS GPCRs class B secretin like CALCRL PTH1R GLP1R ADCYAP1R1 VIPR2 GIPR GCGR SCTR GPR64 CRHR2 GHRHR CALCR ADGRE5 ADGRL1 ADGRL4 ADGRL2 ADGRL3 INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20260610%WP453%HOMO SAPIENS Inflammatory response pathway VTN THBS1 COL1A1 COL1A2 LAMC2 LAMC1 CD40 CD80 IL5RA IL2RG TNFRSF1B COL3A1 IL5 CD40LG LAMA5 IL2RA IL2RB THBS3 IL2 IL4 LAMB2 LAMB1 ZAP70 LCK IFNG TNFRSF1A NEUROINFLAMMATION%WIKIPATHWAYS_20260610%WP4919%HOMO SAPIENS Neuroinflammation MAPK14 MTOR JUN CHUK NOS2 ASCC1 COX2 COX1 RELA NFKBIA MAPK8 TLR4 FOS EFFECTS OF NITRIC OXIDE%WIKIPATHWAYS_20260610%WP1995%HOMO SAPIENS Effects of nitric oxide NOS2 AOX1 COX1 HBB XDH HBA2 IMMUNE INFILTRATION IN PANCREATIC CANCER%WIKIPATHWAYS_20260610%WP5285%HOMO SAPIENS Immune infiltration in pancreatic cancer IL6 CXCL12 VEGFB IL1B VEGFC CSF2 CXCL8 CXCL1 IL23A TNF CXCL5 IL5 IL10 IL25 IL12B IL12A LGALS9 CCL20 IL2 IL4 TGFB1 IL13 IL17F IL17D REG4 VEGFD IL17C CCL28 IL17B IL17A CCL5 CCL2 MMP9 IFNG VEGFA CARNOSINE METABOLISM OF GLIAL CELLS%WIKIPATHWAYS_20260610%WP5313%HOMO SAPIENS Carnosine metabolism of glial cells SLC15A2 CARNS1 SLC15A4 TAR SYNDROME%WIKIPATHWAYS_20260610%WP5362%HOMO SAPIENS TAR syndrome SUMO2 MAGOH NUDT17 HEL-S-76p DDIT4 RBCK1 CFTR SLC22A4 PEX11B FURIN TXN CLCN3 BCL2L13 ITGB1 TNFRSF14 ZFHX3 PEX19 NHERF1 UBE2I PYM1 PDZK1IP1 MITD1 CXCR4 LAMTOR1 FLT3 EGFR STAT3 FARP2 POLR3GL LCK HDAC2 POLR3C SIRT1 POLR3F POLR3G CD160 SLC34A3 NFKB1 HLA-B HLA-C HLA-A HLA-F HLA-G HLA-E HAMP ANKRD35 EIF4A3 CD3D GPR89B IFNG CCAR2 AKAP10 SLK MFAP5 EFFECT ON PERMEABILITY AND MOTILITY OF ENDOTHELIAL CELLS VIA CYTOSKELETON REARRANGEMENT%WIKIPATHWAYS_20260610%WP4560%HOMO SAPIENS MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement PLCG1 JUN PRKCQ HEL114 MYL2 CREB1 MYLK MAPK1 LPP ACTN1 ITGB3 MFAP5 MAPK3 TJP1 ITGAV PXN GENES ASSOCIATED WITH THE DEVELOPMENT OF RHEUMATOID ARTHRITIS%WIKIPATHWAYS_20260610%WP5033%HOMO SAPIENS Genes associated with the development of rheumatoid arthritis IL6ST CD244 IL2RA PHF19 SLC22A4 HLA-DRB1 STAT4 FCRL3 ITGAV CD40 PTPN22 BLK TRAF1 MHC2TA CTLA4 PADI4 CCR6 INSULIN SIGNALING IN ADIPOCYTES DIABETIC CONDITION %WIKIPATHWAYS_20260610%WP3635%HOMO SAPIENS Insulin signaling in adipocytes diabetic condition MTOR TBC1D4 INSR SLC2A4 IRS1 RPS6 RPS6KB1 STATIN INHIBITION OF CHOLESTEROL PRODUCTION%WIKIPATHWAYS_20260610%WP430%HOMO SAPIENS Statin inhibition of cholesterol production ABCG8 ABCG5 LPL SCARB1 MTTP HMGCR LIPC APOB ACSS1 LDLR CYP7A1 PLTP ABCA1 FDFT1 DGAT1 APOA2 APOC3 PDIA2 APOA4 APOA5 SQLE SOAT1 APOC2 APOC1 APOE IL9 SIGNALING%WIKIPATHWAYS_20260610%WP22%HOMO SAPIENS IL9 signaling MAP2K1 MAP2K2 GRB2 PIK3R2 STAT5B PIK3R1 MAPK1 CDK9 IL9 JAK3 MAPK3 IL9R STAT1 JAK1 STAT3 IL2RG HEMATOPOIETIC STEM CELL GENE REGULATION BY GABP ALPHA BETA COMPLEX%WIKIPATHWAYS_20260610%WP3657%HOMO SAPIENS Hematopoietic stem cell gene regulation by GABP alpha beta complex EP300 SMARCA4 BCL2 ATM GABPB1 PTEN CREBBP FOXO3A SMAD4 GABPA FLT3 TERF2 ZFX ETV6 DNMT3B BCL2L1 MCL1 PTDINS 4 5 P2 IN CYTOKINESIS PATHWAY%WIKIPATHWAYS_20260610%WP5199%HOMO SAPIENS PtdIns 4 5 P2 in cytokinesis pathway RDX RAB35 KIF23 OCRL EZR HEL70 MYL2 SEPTIN2 ARHA MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20260610%WP129%HOMO SAPIENS Matrix metalloproteinases TCF20 MMP21 MMP20 MMP25 MMP2 MMP24 MMP27 MMP26 MMP28 TIMP4 MMP7 MMP3 MMP10 MMP12 MMP11 MMP14 MMP16 MMP15 MMP23B MMP17 MMP19 TNF hEMMPRIN MMP9 TIMP3 TIMP1 SARS COV 2 ALTERING ANGIOGENESIS VIA NRP1%WIKIPATHWAYS_20260610%WP5065%HOMO SAPIENS SARS CoV 2 altering angiogenesis via NRP1 FURIN ACE2 NRP1 VEGFA KDR 6Q16 COPY NUMBER VARIATION%WIKIPATHWAYS_20260610%WP5400%HOMO SAPIENS 6q16 copy number variation GHRL AgRP SIM1 POMC INS INSR LEP BDNF NTRK2 GHSR MC4R NPY LEPR PGK1 PKM2 KHKC KHKA ACTING AS PROTEIN KINASES%WIKIPATHWAYS_20260610%WP5433%HOMO SAPIENS PGK1 PKM2 KHKC KHKA acting as protein kinases H3F3B SNAP23 AKT1S1 KHK HEL-S-68p MYL2 HEL-S-30 STAT3 H2AX MIR TARGETED GENES IN MUSCLE CELL%WIKIPATHWAYS_20260610%WP2005%HOMO SAPIENS miR targeted genes in muscle cell HES1 ITGA2 TYMS POLR2C POLD2 EHMT1 POLE4 POLA2 EZH2 MCL1 BACE1 CXCL12 LPL VPS39 NRP1 SNAP23 CPNE8 VEZT SPARC MTRR TMEM41B CLDN1 BACH1 PWP1 CHORDC1 RAVER2 MAPK7 CIAO2A SEC62 CDK5RAP3 MBNL1 ATP6V0E1 HEL-S-303 CACNA2D1 IFRD1 MAPK12 FNDC3B FNDC3A C1QBP PISD CARHSP1 WDR82 FAR1 TMEM87A HACD3 UBE2J1 MRPL20 COMMD9 RDH10 GRPEL2 HMOX1 ATP6V1C1 SNX6 GSTM4 RAB27B MOV10 NCEH1 PDE3A SFXN1 STRN ANP32B RNP24 ARF4 AXL TRAM1 NEDD4 GFM1 ASH2L MAGT1 PTPRF MRC2 PANX1 COIL SERP1 TMEM43 EGFR HYAL3 TMED3 DHX15 PPP1R7 GNPNAT1 NELFCD SH3BP4 TMED7 CTSC MRPS24 LAMTOR3 ELMOD2 TMT1A AP3B1 SLC7A6 CDCP1 VSNL1 CSDE1 FRG1 PXDN PTMA AMIGO2 FSTL1 NAPG PTPA NT5E PGRMC1 USP1 SHOC2 SRSF10 MPZL1 CA12 SPRYD4 AP3D1 TTC9C ARHG ARCN1 WDR11 SPCS3 DOCK5 TPPP3 GPAM NFIA SNX15 CCNG1 PKN2 LAMTOR5 TUSC2 LTN1 PPP3CA CPOX ARID4B TXN2 FADS2 ABHD10 COL1A1 POGLUT3 COL1A2 KPNA3 MYLIP SLC38A1 RARS1 ATG9A ITGB4 SNAP29 STX7 UBE4A LAMC2 CDKAL1 LAMC1 HEL-S-66 RAB30 SYPL1 GPD2 NCL PPIF GEMIN7 PPIB PHLDB2 ABCG2 SRSF9 RAI14 NOTCH2 TMED10 CBFB SLC1A4 ADIPOR2 RTN4 CORO1C CAMTA1 SLC38A5 CD164 BRPF3 GFPT1 SLC4A10 TBCA IGF2R GNL3L P4HA2 CHMP2A SRPRB NF2 DKFZp761E1322 PICALM SLC25A1 CALCOCO2 DOCK7 TNFAIP2 ATP2A2 SSNA1 ADAR CYR61 SYNE1 TMEM109 ACP2 SCYL1 HSDL1 HEL-S-47e NOTCH1 TGFBR2 RCN2 RFT1 RBMS1 DSG2 SLC25A13 SEC23A LUZP1 NUFIP2 NXN YWHAQ UHRF1 HSD17B12 ACVR1B GNA13 DNAJB1 CAND1 TDG CSF1 TP53INP1 IGF2BP1 E2F3 ZNF622 CDIPT PDLIM7 SLC25A24 SLC12A2 GALNT7 ANAPC1 NHERF2 GALNT1 CYP51A1 SLC4A7 RQCD1 MYO1E FMNL2 SLC25A32 CUL4B BET1 IRS1 MTHFD2 GRIA2 HEL-S-30 EIF4E SDCBP RB1 CCND1 SLC7A11 PSAT1 ERG PLK1 RHEB TNFRSF10B BCL2 CDK6 CDKN1A CDKN1B ARID1A SYNE2 SPTLC1 HMGA1 MAPK14 KIT GJA1 CSNK1D FGF2 PRKCI THBS1 CYP1B1 ERBB3 ERBB2 CEBPB HEL-S-273 HEL-S-108 COL3A1 TPM3 TPM1 LMNB2 GENE REGULATORY NETWORK MODELING SOMITOGENESIS %WIKIPATHWAYS_20260610%WP2854%HOMO SAPIENS Gene regulatory network modeling somitogenesis HES1 NOTCH1 MESP2 HES7 LFNG EPHA4 FGF8 RIPPLY2 WNT3A TBX6 OSTEOARTHRITIC CHONDROCYTE HYPERTROPHY%WIKIPATHWAYS_20260610%WP5373%HOMO SAPIENS Osteoarthritic chondrocyte hypertrophy DDR2 FGFR2 PIK3CA PRKCA RELB COL1A1 FGFR1 CEBPB MAPK1 opn NFKB1 LAMTOR1 MAPK3 STAT3 COL2A1 FGF23 AKT3 COL3A1 FGFR3 JUN RELA CTGF IBSP ACAN COL10A1 VHL SOX9 JUNB CNMD P4HTM NTRK1 JUND NGF RUNX2 HIF1A GANC FOSL2 VEGFA FOSL1 KDR FOSB FOS FGFR4 BRAIN DERIVED NEUROTROPHIC FACTOR BDNF SIGNALING%WIKIPATHWAYS_20260610%WP2380%HOMO SAPIENS Brain derived neurotrophic factor BDNF signaling CAMK2A MAPK10 CREB1 RPS6KA5 PRKAA1 RANBP9 IGF2BP1 APC ACACB CRTC1 IRS1 CDH2 TRAF6 GRIA2 NTRK1 NGF FYN EIF4E GRIA3 MAP3K1 RPS6KB1 GRIN2B CYFIP1 NCF1 NCF2 SIRPA RPS6KA1 CSNK2A1 GABRB3 FRS2 FRS3 DOK5 SQSTM1 HEL-S-15 KCNN2 MAP2K1 EIF2S2 EEF2 MAP2K2 SHC2 NFATC4 SHC3 DOCK3 SHC1 YBX1 NCK2 TSC2 NCK1 KSR1 SYN1 KCNA3 NTF3 MEF2C SH2B2 SH2B1 RPS6 RAF1 LINGO1 SORT1 NTRK2 KIDINS220 NTRK3 MARCKS CAMK1 TIAM1 RAP1A CDK5R1 ADAM17 EIF4EBP1 PPP2CA JUN PRKAA2 EIF2S1 MAPK9 NFKBIA GRB2 MAPK7 CDK5 MAP3K2 GRIN1 NGFR BDNF CASP3 HRAS RAC1 VAV2 NCAM1 CDC42 MAPK8 CDKL5 MAPK1 PTPRF PTK2B MAPK3 BAD CNR1 STAT1 STAT3 IKBKB PTPN11 MAPK14 IKBKG MTOR CHUK RELA STAT5B SRC ARHG SHC4 PLCG1 PDPK1 MAP2K5 GSK3B PIK3R2 PIK3R1 RASGRF1 NFKB1 FOXO3A VAV3 GRIP1 CAMK4 CAFFEINE IN MYOCYTES%WIKIPATHWAYS_20260610%WP5603%HOMO SAPIENS Caffeine in myocytes MYL1 MYL2 MYL6 MYL3 HEL-S-273 RYR1 TNNI1 RYR2 TNNI2 TNNI3 HEL-S-108 RYR3 TPM3 ACTG2 TNNC1 MYH13 TPM1 TNNC2 MYH1 MYH2 ACTA2 MYH4 MYH7 TNNT1 TNNT3 MYH8 MYH6 ACTG1 PS1TP5BP1 MYL11 ACTA1 FAMILIAL HYPERLIPIDEMIA TYPE 3%WIKIPATHWAYS_20260610%WP5110%HOMO SAPIENS Familial hyperlipidemia type 3 LPL SCARB1 LIPC VLDLR APOE LDLR PLTP APOA2 APOA4 HALLMARK OF CANCER METASTASIS AND EPITHELIAL TO MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260610%WP5469%HOMO SAPIENS Hallmark of cancer metastasis and epithelial to mesenchymal transition SUV39H1 SIX1 SUZ12 FOXC2 PRRX1 KDM1A KLF8 ZEB2 ELF3 ELF5 TGFB1 SNAI1 SNAI2 GSC2 HDAC2 TWIST1 SIRT1 HDAC1 TCF4 EZH2 TYPE I COLLAGEN SYNTHESIS IN THE CONTEXT OF OSTEOGENESIS IMPERFECTA%WIKIPATHWAYS_20260610%WP4786%HOMO SAPIENS Type I collagen synthesis in the context of osteogenesis imperfecta TNFRSF11B P3H1 BMP1 P4HA1 SP7 MBTPS2 COL1A1 COL1A2 PPIB LRP5 P4HA2 PLOD2 MIA3 TNFRSF11A PLOD1 LRP6 ADAMTS2 TMEM38B COLGALT1 IFITM5 FZD1 WNT1 MBTPS1 CRTAP TNFSF11 P3H2 TRANSCRIPTIONAL ACTIVATION BY NRF2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20260610%WP3%HOMO SAPIENS Transcriptional activation by NRF2 in response to phytochemicals PIK3CA PRKCA HMOX1 NQO1 GCLM KEAP1 AIMP2 GCLC MAF SLC7A11 MAPK8 NFE2L2 CEBPB EPHB2 KALLMANN SYNDROME%WIKIPATHWAYS_20260610%WP5074%HOMO SAPIENS Kallmann syndrome PTPN11 ANOS1 PIK3CA FRS2 PLXND1 MYRF FGF8 LHB SEMA3E FGFR1 MAP2K2 OLIG2 GRB2 SOX10 TMEM98 PROK2 GNRH1 OTX2 MAPK1 NEUROG1 ASCL1 ARIPIPRAZOLE METABOLIC PATHWAY%WIKIPATHWAYS_20260610%WP2640%HOMO SAPIENS Aripiprazole metabolic pathway CYP3A43 STEROID BIOSYNTHESIS%WIKIPATHWAYS_20260610%WP496%HOMO SAPIENS Steroid biosynthesis F13B HSD17B1 HSD17B2 HSD3B2 HSD17B3 HSD17B4 HSD17B7 HSD3B1 CYP17A1 CPN1 PERTURBED THYROID HORMONE HOMEOSTASIS LEADING TO DEVELOPMENTAL NEUROTOXICITY%WIKIPATHWAYS_20260610%WP5517%HOMO SAPIENS Perturbed thyroid hormone homeostasis leading to developmental neurotoxicity SLC7A5 SLCO1C1 SLCO3A1 SLCO4A1 SLC16A2 SLCO1A2 SLC16A10 TRIACYLGLYCERIDE SYNTHESIS%WIKIPATHWAYS_20260610%WP325%HOMO SAPIENS Triacylglyceride synthesis AGPAT3 GPAM AGPAT4 LIPF GNPAT LIPE GPD1 LIPC PLPP3 PLPP2 PLPP1 PNPLA2 DGAT1 LPL AGPAT5 DGAT2 MOGAT3 MOGAT2 MOGAT1 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES APOPTOSIS%WIKIPATHWAYS_20260610%WP4864%HOMO SAPIENS Host pathogen interaction of human coronaviruses apoptosis MAPK14 BAX BCL2L11 BCL2 BBC3 MAPK12 MAPK13 CASP9 MAPK11 CASP8 APAF1 CASP3 BAD TNFSF6 TNF FADD BCL2L1 MCL1 DEVELOPMENT OF PULMONARY DENDRITIC CELLS AND MACROPHAGE SUBSETS%WIKIPATHWAYS_20260610%WP3892%HOMO SAPIENS Development of pulmonary dendritic cells and macrophage subsets IRF4 BATF3 FLT3LG IKZF1 TPO GIG8 IRF8 CSF2 CSF1 SPI1 RUNX2 STAT3 TCF4 SHANK3 PATHWAY INVOLVED IN PHELAN MCDERMID SYNDROME%WIKIPATHWAYS_20260610%WP5566%HOMO SAPIENS SHANK3 pathway involved in Phelan McDermid syndrome CAMK2A GRIN2B DLG4 CDC42 SYNGAP1 ITGB1 PAK1 ADGRL1 RAP1A SHANK3 SPAAR PS1TP5BP1 CTNND2 ARHGAP44 SHARPIN DLGAP1 MAP3K7 SPTAN1 LZTS3 BAIAP2 GRIN1 GRIA2 ARHGEF7 HCN1 HRAS HOMER1 PHASE I BIOTRANSFORMATIONS NON P450%WIKIPATHWAYS_20260610%WP136%HOMO SAPIENS Phase I biotransformations non P450 PON3 PON2 ESD PON1 HEL126 LIPA CES2 CES1 CANCER IMMUNOTHERAPY BY PD 1 BLOCKADE%WIKIPATHWAYS_20260610%WP4585%HOMO SAPIENS Cancer immunotherapy by PD 1 blockade NFAT5 PTPN11 NFATC3 NFATC2 JUN NFATC1 CD3G BATF PDCD1LG2 CD3E CD8B CD8A NFATC4 ZAP70 HLA-DRB1 LCK PDCD1 NFKB1 HLA-A CD3D IFNG STAT3 SUDDEN INFANT DEATH SYNDROME SIDS SUSCEPTIBILITY PATHWAYS%WIKIPATHWAYS_20260610%WP706%HOMO SAPIENS Sudden infant death syndrome SIDS susceptibility pathways HEL-S-87p HSPD1 HES5 KCNJ8 NFYA HEL-S-93 EGR1 GCK NR3C1 PRKAR1B REST HEL2 SST PRKAR1A DDC GPD1L CREB1 YWHAQ TH HEL-S-1 HES1 YWHAG IL1RN CXCL8 TNF EP300 GATA3 IL6R IL10 HEL-S-162eP SLC1A3 NGF IL6 YBX1 G6PC1 MEF2C NTRK2 SNAP25 JUN CAV3 SP1 NR1A2 SCN4B VAMP2 GRIN1 CTCF BDNF CASP3 HEL-S-125m POU2F2 MYB IL1B PPARGC1A ASCL1 RYR2 GJA1 MAOA ECE1 CREBBP MAP2 HIF1A VEGFA HTR1A HTR2A CHRM2 AQP4 RORA SOX2 ADCYAP1R1 VIPR2 C4A PKNOX1 CHRNB2 CHRNB4 CPT1A TSPYL1 POU3F2 CEBPB RUNX3 SLC9A3 NFKB1 NR3A2 NFKB2 LMX1B TPH2 DLX2 TPH1 CHRNA7 CREM BHLHB2 GATA2 C4B_2 NEUROD1 DEAF1 RET ChAT SCN3B SPTBN1 NKX2-2 PBX1 PHOX2B PHOX2A TF TLX3 FEV PAH SP3 GNB3 TCF3 IL13 CC2D1A TP73 FOXM1 FREP1 SCN5A ACADM SNTA1 NKX3-1 PPARGC1B EN1 TACR1 SSTR2 IL1A POU5F1 HADHB HDAC1 NOS1AP AVP SLC25A4 EFFECT OF OMEGA 3 PUFA ON HUNTINGTON 39 S DISEASE PATHWAYS%WIKIPATHWAYS_20260610%WP5470%HOMO SAPIENS Effect of omega 3 PUFA on Huntington 39 s disease pathways MAPK10 REST CYP46A1 KIF5A CREB1 RPS6KA5 ABCG4 ABCG1 PI3 DHCR7 AHI-1 OPA1 PRKAA1 SIN3A HMGCS1 C1QA BNIP3 NR1H2 RAB3GAP1 SLC12A2 CYP51A1 HMGCR BCL2L11 PIK3CD GABRG3 GABRG1 HDAC2 EIF4E BCL2L1 RPS6KB1 PIK3R4 GABRB3 IL6 GABRB2 GABRB1 PRKAB2 MAP2K1 PRKAB1 MAP2K2 TSC2 TSC1 MAP3K10 RAF1 NTRK2 PRKAG1 PRKAG2 PRKAG3 EIF4EBP1 SREBF2 RHEB GABRE SP1 PRKAA2 GABRQ ABCA1 GABRA2 GABRP BCL2 MAPK9 SLC12A5 GABRA6 GABRA5 GABRA4 GABRA3 PIK3R5 PTEN RPTOR CASP8 BDNF CASP3 HRAS PIK3CA HTT DEPTOR IL1B MAPK8 AKT1S1 MAPK1 PPARGC1A RICTOR MAPK3 EGFR BAD IKBKB HAP1 AKT3 MBP MTOR BAX APOE HEL-S-29 PIK3C2G PIK3C2B MAP2K4 EGF PIK3R3 PIK3R2 PIK3R1 NFKB1 MLST8 NEUROD1 HDAC1 PHYSIOLOGICAL AND PATHOLOGICAL HYPERTROPHY OF THE HEART%WIKIPATHWAYS_20260610%WP1528%HOMO SAPIENS Physiological and pathological hypertrophy of the heart PRKCB IL6ST MAPK14 JUN PRKCE PPP3CA MAP2K3 MYEF2 GATA4 NFATC4 ARHA CALM1 MAPK8 MAPK1 CAMK2D CTF1 MAPK11 EDN1 STAT3 RAC1 FOS FOLATE ALCOHOL AND CANCER PATHWAY HYPOTHESES%WIKIPATHWAYS_20260610%WP1589%HOMO SAPIENS Folate alcohol and cancer pathway hypotheses CYP2E1 CEBPB MTR HEL-S-53e CREB1 ADH5 CBS G PROTEIN SIGNALING%WIKIPATHWAYS_20260610%WP35%HOMO SAPIENS G protein signaling PLCB3 PRKAR1B PRKAR1A GNAS ARHA GNA13 GNAO1 HEL159 GNGT1 AKAP12 AKAP11 GNGT2 GNAI1 RRAS PPP3CC PRKACG PDE4B PDE4A PDE8A PDE4D PRKD3 AKAP9 ADCY3 ARHGEF1 PRKD1 GNAZ ADCY1 PDE1C PDE1B ADCY8 PDE1A AKAP8 GNAI3 ADCY6 AKAP7 AKAP6 ADCY5 AKAP4 ADCY9 GNA14 GNA15 GNG3 GNG10 GNG5 GNG4 GNG7 GNG8 KCNJ3 GNG12 GNG11 GNG13 GNAL PRKCB GNB2 PRKCI GNB1 PRKCH PDE7B GNB5 PRKCA PDE7A PRKCQ PRKCZ PPP3CA NRAS AKAP5 PRKCE GNA11 GNB3 CALM1 HRAS AKAP10 VITAMIN D IN INFLAMMATORY DISEASES%WIKIPATHWAYS_20260610%WP4482%HOMO SAPIENS Vitamin D in inflammatory diseases MAPK14 IKBKG CHUK NFATC1 NR1i1 NR3C1 PPP3R1 IL6 MED14 PPP3CA MAP2K3 RELA NFKBIA RXRA NFKB1 SMAD4 MAP2K6 MAP3K1 TNF IKBKB CHOLESTASIS%WIKIPATHWAYS_20260610%WP5238%HOMO SAPIENS Cholestasis SCARB1 EPHX1 HMGCR ABCC3 ATP8B1 ABCB4 LDLR ABCG8 ABCC2 NR1I3 SLC22A1 ABCG5 NR1H4 ABCB11 RXRA SLCO1A2 TYROSINE KINASE INHIBITORS IN GLIOBLASTOMA%WIKIPATHWAYS_20260610%WP5494%HOMO SAPIENS Tyrosine kinase inhibitors in glioblastoma MTOR SOS1 RHEB SOS2 EGF TGFA TYK2 GRB2 EREG BTC TSC2 TSC1 PTEN NRAS RPTOR JAK3 RAF1 HRAS JAK1 STAT3 AKT3 HIPPOCAMPAL SYNAPTOGENESIS AND NEUROGENESIS%WIKIPATHWAYS_20260610%WP5231%HOMO SAPIENS Hippocampal synaptogenesis and neurogenesis CAMK2A NRXN3 MAPK14 PRKCA RPS6KA1 CREB1 RPS6KA5 BCL2 CALM1 SYT2 NRXN1 NRXN2 CAMKK1 CCND2 MAPK1 CAMKK2 CAMK4 HNRNPL PPARGC1A DRD1 PRL BDNF NGF NCAM1 PI3K AKT SIGNALING%WIKIPATHWAYS_20260610%WP4172%HOMO SAPIENS PI3K Akt signaling DDIT4 CREB1 ITGB1 VEGFB VEGFC ITGA4 ITGA2 ITGB7 GNGT1 GNGT2 IL6R IFNAR2 IFNAR1 GNG3 GNG10 JAK3 GNG5 GNG4 GNG7 GNG8 GNG12 GNG11 GNG13 BCL2L1 MCL1 IFNB1 GNB2 GNB1 GNB5 IL6 TGFA PCK1 G6PC1 ATF2 PPP2R2A RPS6 TCL1B TCL1A NTRK2 PPP2R1B CREB3L3 PPP2R1A CREB3L4 CREB3L2 KPG_010 CDC37 ATF4 PDGFA EPHA2 LPAR2 LPAR3 CD19 IGF2 COL9A1 PRKAA2 COL9A3 COL9A2 INS IFNA5 IFNA4 IFNA7 IL4 IFNA6 IFNA1 IFNA2 IFNA8 GYS2 SYK OSMR SGK1 SGK2 ITGB3 PRL PHLPP2 PHLPP1 ITGAV GYS1 PKN3 NTF4 OSM CSHL1 RAC1 GHB2 KITLG GHB3 PKN1 CSF3 ITGA6 CSF3R CHRM1 EPO FGF3 FGF4 FGF6 FGF7 FGF9 IFNA13 IFNA14 IFNA16 IFNA17 PRLR COL4A3 COL4A5 IFNA10 CSH2 EFNA5 EFNA4 FGF20 FGF22 FGF21 IFNA21 EGFR FGF17 EFNA1 GH1 EFNA3 FGF14 EFNA2 IL7 FGF19 FGF18 GNB4 IL7R ITGA2B FGF10 TNC HSP90AB1 FLT4 GHR PPP2R5E PPP2R5B PPP2R5A PPP2R5D COMP PPP2R5C RBL2 IBSP CREB3 TNR COL6A1 IL3RA COL6A6 COL6A5 CREB5 COL4A2 ATF6B COL4A1 GNG2 COL4A4 PPP2R3C COL4A6 ANGPT4 ANGPT2 LAMB4 PPP2R3B PPP2R3A EPOR PPP2R2C PPP2R2B VTN PPP2R2D PDGFD PIK3AP1 CHAD PDGFC PKN2 COL1A1 GSK3B COL1A2 PIK3R3 PIK3R2 PIK3R1 ITGB4 NRAS LAMC2 LAMC1 MLST8 ITGB8 FOXO3A ITGB6 VWF COL2A1 ITGA7 LAMA5 LAMA1 LAMA4 LAMA3 THBS2 THBS4 THBS3 RELN LAMB3 LAMB2 LAMB1 VEGFD XB LPAR4 ITGA1 LPAR1 STK11 PRKAA1 CSF1 BCL2L11 IRS1 PIK3CD FGF8 IL2 NTRK1 NGF EIF4E EIF4B FGFR4 RPS6KB1 CCND1 MYC MAP2K1 MAP2K2 HGF TSC2 CCND3 TSC1 CCND2 NTF3 EIF4E1B RAF1 CCNE2 CCNE1 EIF4EBP1 PPP2CA RHEB CDK4 CDK2 FGF13 BCL2 CDK6 MDM2 GRB2 FGF12 CDKN1A PIK3R5 CDKN1B PTEN BRCA1 F2R RPTOR CASP9 NGFR BDNF HEL-S-125m HRAS JAK1 PIK3CA SOS1 MYB MAPK1 MAPK3 FLT3 BAD IKBKB AKT3 IKBKG G6PC2 MTOR G6PC3 CHUK KIT SOS2 CSF1R FLT3LG RELA PDGFRA IL3 FLT1 RPS6KB2 ANGPT1 FGF2 VEGFA IGF1R KDR FGFR2 PDPK1 PRKCA THBS1 EGF CHRM2 FGFR1 IGF1 TLR4 opn INSR NFKB1 PCK2 IL2RG FGF23 FGFR3 IL2RA IL2RB GNB3 TNFSF6 MITOCHONDRIAL CARRIER DEFICIENCY ASSOCIATED WITH SHUTTLE DISTURBANCES%WIKIPATHWAYS_20260610%WP5507%HOMO SAPIENS Mitochondrial carrier deficiency associated with shuttle disturbances SLC25A12 SLC25A22 GOT2 SLC25A13 GLUD1 GASTRIC ACID PRODUCTION%WIKIPATHWAYS_20260610%WP2596%HOMO SAPIENS Gastric acid production CBLIF SCT GAST PGA3 VIP PGC PGA5 MUC6 CCK MEVALONATE PATHWAY%WIKIPATHWAYS_20260610%WP3963%HOMO SAPIENS Mevalonate pathway HMGCS1 HMGCR MVD FDPS MVK PMVK ACAT2 ETHYLMALONIC ENCEPHALOPATHY%WIKIPATHWAYS_20260610%WP5030%HOMO SAPIENS Ethylmalonic encephalopathy ETHE1 SUOX PRO SURVIVAL SIGNALING OF NEUROPROTECTIN D1%WIKIPATHWAYS_20260610%WP5182%HOMO SAPIENS Pro survival signaling of neuroprotectin D1 BIRC3 BAX TRAF2 CYCS RIPK3 TRADD CASP9 CASP8 CASP3 RIPK1 TNF FADD TNFRSF1A HEMOGLOBIN SWITCHING EMBRYONIC FETAL AND ADULT%WIKIPATHWAYS_20260610%WP5605%HOMO SAPIENS Hemoglobin switching embryonic fetal and adult HBZ tal-1 HBG2 LDB1 HBG1 LMO2 HBB HBE1 HBA2 HBD GATA1 SYNAPTIC SIGNALING ASSOCIATED WITH AUTISM SPECTRUM DISORDER%WIKIPATHWAYS_20260610%WP4539%HOMO SAPIENS Synaptic signaling associated with autism spectrum disorder GRIN2B GRIN3B GRIN3A PIK3CA DLG4 ARC PRKAB2 SYNGAP1 NF1 GSK3B PRKAB1 PIK3R3 PRKAA1 PIK3R2 PIK3R1 TSC2 TSC1 NRAS MAPK1 MAPK3 NTRK2 UBE3A PRKAG1 CACNA1C PRKAG2 PRKAG3 AKT3 SHANK3 EIF4EBP1 MTOR RHEB PRKAA2 PIK3CD PTEN GRIN1 CAMK4 RPTOR BDNF HRAS HOMER1 RPS6KB1 METABOLIC EPILEPTIC DISORDERS%WIKIPATHWAYS_20260610%WP5355%HOMO SAPIENS Metabolic epileptic disorders HEL-S-87p SPCS1 CDO1 PFKM PFKP HEL60 GCK OTC CBS SFXN1 ECHS1 PC HEL-S-162eP HEL-S-30 HEL-S-20 ENO1 HK3 PSPH PDHA1 MDH2 PGAM1 SHMT1 CTH HEL-S-51e GOT2 HEL-S-133P HEL-S-68p ASL GPT ASS1 GLUD1 PFKL PSAT1 ALDOB ETHE1 SUOX PCK1 G6PC1 SLC2A4 MOCS2 MOCS3 GLS2 GLDC SLC2A2 SLC2A3 ENO2 ENO3 GPHN HK2 DHTKD1 MPC1 FBP1 XDH MPC2 PHGDH DLAT AASS ARG1 PGAM2 AMT SLC25A15 BTD SLC25A5 ALDH7A1 DLD MOCS1 FBP2 GCDH SLC25A1 SLC7A2 ACAT1 HLCS PKLR AADAT HEL-S-32 SQOR HEL-S-281 HEL-S-49 HALLMARK OF CANCER SUSTAINING PROLIFERATIVE SIGNALING%WIKIPATHWAYS_20260610%WP5475%HOMO SAPIENS Hallmark of cancer sustaining proliferative signaling PIK3CA SOS1 SALL4 AXIN2 TTI1 GAREM2 PYGO1 RETN DEPTOR CSNK1A1 BCL9 NFKBIE AKT1S1 MAPK1 MAPK3 FLT3 EGFR APC NR1C2 STAT3 IKBKB AKT3 IKBKG MTOR CHUK IL6R KIT FLT4 SOS2 CSF1R PIK3CD LEF1 RELA RUNX1T1 PDGFRA JUP ZBTB16 FLT1 NTRK1 SRC IGF1R KDR FGFR4 REL FGFR2 IL6 CCND1 MYC MAP2K1 GSK3B ULK2 FGFR1 MAP2K2 SHC1 TSC2 KSR1 TSC1 FOXO1 INSR NFKB1 MLST8 RAF1 NTRK2 FGFR3 JUN EPHA2 RHEB PML MDM2 NFKBIA GRB2 TCF3 CDKN1A LRP5 PTEN RPTOR LRP6 NGFR HRAS WNT1 FOS RARA BONE MORPHOGENIC PROTEIN SIGNALING AND REGULATION%WIKIPATHWAYS_20260610%WP1425%HOMO SAPIENS Bone morphogenic protein signaling and regulation NOG SMAD6 BMPR2 TOB2 TOB1 BMPR1A SMAD1 SMAD4 RUNX2 BMP2 SMURF1 HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20260610%WP313%HOMO SAPIENS Hepatocyte growth factor receptor signaling PIK3CA RAPGEF1 ITGA1 SOS1 CRK CRKL DOCK1 MAP2K1 ITGB1 MAP2K2 MAPK8 PAK1 HGF MAPK1 PTK2B MAPK3 RAF1 PXN STAT3 RAP1A PTPN11 JUN GRB2 PTEN SRC HRAS PTGS2 MAP4K1 FOS MIR TARGETED GENES IN ADIPOCYTES%WIKIPATHWAYS_20260610%WP2001%HOMO SAPIENS miR targeted genes in adipocytes SRSF9 CAP1 TMED10 TGFBR2 CYP1B1 IGF2R LPL CEBPB PHC2 ELOVL5 SRSF10 FADS1 PICALM TMEM43 TUMOR SUPPRESSOR ACTIVITY OF SMARCB1%WIKIPATHWAYS_20260610%WP4204%HOMO SAPIENS Tumor suppressor activity of SMARCB1 ARID1A ARID1B RB1 SMARCD1 SMARCD2 SMARCD3 SMARCC1 SMARCC2 GLI4 RBBP4 DPF1 DPF2 DPF3 SMARCE1 CDKN2A PTCH1 SMARCA4 GLI3 SUZ12 CDK4 CDK6 H3F3B EED ACTL6B ACTL6A SMO EZH2 EICOSANOID SYNTHESIS%WIKIPATHWAYS_20260610%WP167%HOMO SAPIENS Eicosanoid synthesis ALOX15 ALOX12 PLA2G5 ALOX15B PRXL2B PTGES PLA2G6 ALOX5 ALOX5AP LTC4S PTGS2 PTGIS PTGS1 PLA2G4B SUPPRESSION OF HMGB1 MEDIATED INFLAMMATION BY THBD%WIKIPATHWAYS_20260610%WP4479%HOMO SAPIENS Suppression of HMGB1 mediated inflammation by THBD IKBKG CHUK NFKB1 THBD HMGB1 AGER RELA IKBKB NFKBIA CONTROL OF IMMUNE TOLERANCE BY VASOACTIVE INTESTINAL PEPTIDE%WIKIPATHWAYS_20260610%WP4484%HOMO SAPIENS Control of immune tolerance by vasoactive intestinal peptide IL5 IL10 VIP CD80 IFNG IL12A CTLA4 IL4 IL2 TGFB1 MITOCHONDRIAL FATTY ACID OXIDATION DISORDERS%WIKIPATHWAYS_20260610%WP5123%HOMO SAPIENS Mitochondrial fatty acid oxidation disorders ACADVL SLC22A5 ACSF2 CPT2 ACADL EHHADH SLC25A20 ACADS CPT1A ACADM PECR ACSL1 HADHB FACL4 ACSL3 HEAD AND NECK SQUAMOUS CELL CARCINOMA%WIKIPATHWAYS_20260610%WP4674%HOMO SAPIENS Head and neck squamous cell carcinoma PIK3CA TGFBR2 DDIT4 NOTCH1 KEAP1 STK11 PRKAA1 RICTOR EGFR CDKN2A AKT3 MTOR TERT TRAF3 RELA MAML1 SESN2 TP63 NUMB IRF6 AJUBA CSMD3 RPS6KB2 FKBP1A SMAD4 FAT1 EIF4E LTBR IGF1R FADD VEGFA REL PDPK1 RB1 CCND1 ERBB2 FGFR1 MAPKAP1 PIK3R2 TSC2 PIK3R1 NFE2L2 TSC1 NRAS SESN1 NFKB1 NFKB2 MLST8 RPS6 BIRC2 EIF4EBP1 FGFR3 NOTCH2 RHEB CDK4 PRKAA2 CDK6 CDKN1A PIK3R5 PTEN RPTOR CASP8 HRAS HAIR FOLLICLE DEVELOPMENT ORGANOGENESIS STAGE 2 OF 3%WIKIPATHWAYS_20260610%WP2839%HOMO SAPIENS Hair follicle development organogenesis stage 2 of 3 GJB6 FGFR2 CCND1 MYC ITGB1 CCND2 NFKB1 PTCH1 LAMA5 PDGFA SHH LEF1 SNAI1 LRP5 TP63 PDGFRA BMP4 RUNX2 FOXI3 FZD1 TNLG7C INHBA NCAM1 GTPBP4 SMO EDAR ALA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260610%WP5136%HOMO SAPIENS ALA oxylipin metabolism ALOX15 EPHX2 ALOX5 RETINOBLASTOMA GENE IN CANCER%WIKIPATHWAYS_20260610%WP2446%HOMO SAPIENS Retinoblastoma gene in cancer POLE SIN3A WEE1 E2F3 RBBP4 PRIM1 TYMS POLD3 SUV39H1 CCNA2 HMGB1 RRM1 RRM2 DHFR POLA1 POLE2 MCM7 TOP2A ORC1L HMGB2 SMC2 RB1 SKP2 RFC3 CCND1 RFC4 PRMT2 MYC SAP30 CHEK1 TFDP1 TFDP2 RBP1 PCNA TTK NPAT CDC45 HLTF CCND3 E2F2 CDC25B RBBP7 MSH6 H2AZ1 PLK4 CDT1 RPA1 RAF1 FANCG RPA3 SMC1A CCDC6 PRKDC ZNF655 CCNE2 CCNE1 BARD1 CCNB2 CCNB1 CDC2 MCM3 CDK4 FAF1 CDK2 MCM6 CDK6 MDM2 CDKN1A CDKN1B MAPK13 SMC3 HDAC1 16P11 2 PROXIMAL DELETION SYNDROME%WIKIPATHWAYS_20260610%WP4949%HOMO SAPIENS 16p11 2 proximal deletion syndrome HEL-S-87p HEL-S-100n C16orf54 CCT6A TAOK2 YPEL3 NR3C1 MAPK3 CDIPT KMT2C TRAF2 MAP2K3 PPP2R5D TRAF6 TBX6 MLL2 MAP2K6 REL EZR HEL70 PCNA NFKB1 PPARG CCDC6 SMEK1 DOC2A PPP2R1A FAM57B FIMP CCT6B PPP2CA PAGR1 PRRT2 SPN PPP4R1 PPP4R2 PPP4R4 UNC13B UNC13A PARP4 HEL-S-69 PPP4R3B ASPHD1 TCP1 KCTD13 ZG16 INO80E PAXIP1 HDAC3 MVP PTEN GDPD3 CORO1A HIRA HIRIP3 CASP8 PPP4C CCT8 CCT7 BPTF CCT4 IGBP1 HEL-S-90n SIAH1 15Q25 COPY NUMBER VARIATION%WIKIPATHWAYS_20260610%WP5408%HOMO SAPIENS 15q25 copy number variation SPCS1 SH3GL3 HTT RAMAC ZNF592 RNMT EGF BNC1 AGAP2 TENT4B BTBD1 GOLGA6L4 ADAMTSL3 C15orf40 FSD2 AP3S1 WHAMM SEC11A NMB HOMER2 NMBR RYR1 WDR73 RYR2 AP3B2 DNM3 RAF1 SPCS2 SYNJ1 ALPK3 ZSCAN2 SHANK1 SHANK3 PDE8A AP3D1 SPCS3 BETA GLOBIN GENE EXPRESSION REGULATION%WIKIPATHWAYS_20260610%WP5606%HOMO SAPIENS Beta globin gene expression regulation NR2C2 GATAD2B KLF1 MTA2 ZFPM1 ZBTB7A MYB HBB KDM1A HDAC2 tal-1 HBG2 LDB1 PPARGC1A HBG1 LMO2 HBE1 HBD GATA1 HDAC1 CHD3 MICRORNA NETWORK ASSOCIATED WITH CHRONIC LYMPHOCYTIC LEUKEMIA%WIKIPATHWAYS_20260610%WP4399%HOMO SAPIENS MicroRNA network associated with chronic lymphocytic leukemia ZAP70 BCL2 MCL1 DEREGULATING CELLULAR METABOLISM THROUGH NON GENOTOXIC CARCINOGENS%WIKIPATHWAYS_20260610%WP5571%HOMO SAPIENS Deregulating cellular metabolism through non genotoxic carcinogens HSPD1 MTOR ATF4 GDF15 MARS1 OMA1 IRS1 PHB2 SLC7A7 MYC CLPP LONP1 LONP2 EIF2A TSC2 SESN2 TSC1 FOXO1 N GLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260610%WP5153%HOMO SAPIENS N glycan biosynthesis RFT1 DPAGT1 B4GALT2 B4GALT1 TUSC3 GMPPB MAN1A2 MAN1A1 ALG8 ST6GAL1 ALG9 ST6GAL2 ALG6 ALG5 ALG2 ALG14 ALG13 ALG3 ALG12 ALG1 ALG11 ALG10 DDOST DPM1 DPM2 DPM3 GCS1 MAN1B1 ALG10B RPN2 RPN1 FUT8 GANAB MAN2A2 MAN2A1 MGAT5 MGAT5B MGAT3 MGAT1 MGAT2 MPDU1 SRD5A3 DOLK MGAT4C MGAT4D MGAT4A DOLPP1 MGAT4B STT3A STT3B 5Q35 COPY NUMBER VARIATION%WIKIPATHWAYS_20260610%WP5380%HOMO SAPIENS 5q35 copy number variation MAGED1 MAPK10 ABRAXAS1 USH1C ABHD5 BRCC3 NTN1 SOS1 COX5A COX7A1 INPP5D LMAN2 RAB24 COX3 ZNF346 SNCB DRD2 SNCA PRELID1 RNP24 MAPK8 PTPRN2 NOP16 MUPCDH HIGD2A TSPAN17 CXCR4 ANKS4B MXD3 PDLIM7 GNAI1 FGF19 PNPLA2 GNAI3 H3F3B EED ADAM10 SRC HK3 IGF1R FGFR4 PLCG1 GRIN2B FRS2 MYC H2AX PTH SLC34A1 PIK3R1 HEL-S-273 EIF4E1B PRR7 COX7B BARD1 KIAA1191 FAF2 TMED10 JUN DDX41 TRIAP1 COX6A1 COX2 COX7C COX1 BABAM1 BABAM2 UIMC1 CYP7A1 CAPN3 NELFB KDM6B MAPK9 ARL10 GRB2 COX8A TMED9 RNF44 UNC5A FBXW7 CLTB MYO7B BRCA1 COX6B1 GRIN1 ARFGAP2 HIC2 DOK3 GPRIN1 CDHR2 FAM193B PFN3 DBN1 RGS14 MAX CORTICOTROPIN RELEASING HORMONE SIGNALING%WIKIPATHWAYS_20260610%WP2355%HOMO SAPIENS Corticotropin releasing hormone signaling CAMK2A CREB1 GNAS ARHA MAPK8 MAPK1 CXCL8 CRHBP SULT2A1 MAPK3 TRIM28 GNAO1 DKFZp686L0365 HSD3B2 KRT1 ERN1 CYP21A2 IVL TCF4 CACNA1H HSD3B1 GNAI1 CYP11A1 STAR ACACA MAPK14 KRT14 GJA1 GNAZ RELA IL2 ECE1 JUNB JUP JUND FOSL2 FOSL1 FOSB TFAP2A PRKCB PLCG1 GNB2 PRKCI GNB1 GNB5 PRKCA PRKCQ POMC MAP3K5 PLCG2 CRH MAP2K1 GSK3B CRHR2 TLR4 NFKB1 RAF1 GNA11 PRKAA2 SP1 BCL2 MAPK9 NFKBIA GNB3 TGFB1 CASP9 IL18 CASP3 CASP12 FOS GLYCOLYSIS AND GLUCONEOGENESIS%WIKIPATHWAYS_20260610%WP534%HOMO SAPIENS Glycolysis and gluconeogenesis HEL-S-87p PDHA1 MDH2 PFKM PGAM1 PFKP GOT2 HEL-S-133P GCK HEL-S-68p PFKL ALDOB PCK1 G6PC1 SLC2A4 SLC2A2 SLC2A3 ENO2 PC ENO3 HK2 MPC1 FBP1 MPC2 DLAT HEL-S-162eP PGAM2 DLD FBP2 HEL-S-30 ENO1 PKLR HK3 HEL-S-32 HEL-S-281 HEL-S-49 DEREGULATION OF RAB AND RAB EFFECTOR GENES IN BLADDER CANCER%WIKIPATHWAYS_20260610%WP2291%HOMO SAPIENS Deregulation of Rab and Rab effector genes in bladder cancer MLPH RPH3A MADD SYTL1 MYRIP SYTL5 UNC13D RAB27B TBC1D10A SYTL2 EXPH5 RAB27A MAPK SIGNALING%WIKIPATHWAYS_20260610%WP382%HOMO SAPIENS MAPK signaling MAPK10 TGFBR2 RPS6KA5 MAPKAPK2 DKFZp686L0365 TNF CACNA1H PLA2G4B PPP3CC PRKACG TRAF2 RPS6KA4 FGF8 IL1R2 MAP2K3 CACNA2D3 CACNA2D2 CACNA2D4 TRAF6 MAPK8IP2 MAPK8IP3 MAPK8IP1 CACNB1 CACNB3 CACNB4 DDIT3 MAPKAPK5 CACNA1B NTRK1 CACNA1A JUND STK4 NGF NLK CACNA1F RASGRP4 MAP2K6 GNG12 RASGRP3 MAP3K1 CACNA1G CACNA1I FGFR4 PPP3R2 CACNA1S HSPA2 FGF16 PPP5C RASGRF2 MAP3K8 PPP3R1 LRRK2 CRKL MAP3K6 ECSIT DUSP16 MAP3K5 DUSP10 MYC DUSP4 DUSP2 MAP2K1 PLA2G4F DUSP3 MAP2K2 PLA2G4D PLA2G4E PLA2G4C HEL-S-72p RRAS2 DUSP8 CDC25B DUSP9 TGFBR1 MAP3K13 DUSP7 NTF3 MEF2C MAP3K14 PPM1B ATF2 MAP3K11 RAPGEF2 RAF1 MAP3K12 CACNG6 CACNG7 CACNG1 NTRK2 HEL-S-31 CACNG3 CACNG4 CACNG5 RAP1A MAP3K7IP1 TAOK3 TAOK1 CACNG8 pk ATF4 PDGFA JUN MAP4K2 PTPN5 HSPA1A CACNG2 GADD45A FGF13 MAPK9 GRB2 FGF12 MAPK7 MAP4K3 MAP3K2 IL1R1 CACNA2D1 MAPK12 MAPK13 MAPK11 BDNF CASP3 HRAS NTF4 MAP4K1 RAC1 FOS RASA2 TAOK2 SOS1 FGF3 CRK FGF4 RELB FGF6 CDC42 FGF7 FGF9 FLNA FLNB IL1B MAPK8 PAK1 MAPK1 FGF20 FGF22 MAPK3 FGF21 FGF17 EGFR ARAF FGF14 IKBKB AKT3 RRAS FGF19 MAPK14 FGF18 IKBKG LAMTOR3 CHUK FGF10 SOS2 RELA CD14 FGF2 MAP2K4 NFATC3 FGFR2 NFATC1 PRKCA PPP3CA EGF MAP2K5 NF1 FGFR1 RASGRF1 NRAS NFKB1 NFKB2 RAC3 CACNA1C FGF23 FGFR3 TGFB1 MAP3K7 HEL-S-102 IL1A TNFSF6 MAPKAPK3 SMIM40 MAX TNFRSF1A HYPOXIA MEDIATED EMT AND STEMNESS%WIKIPATHWAYS_20260610%WP2943%HOMO SAPIENS Hypoxia mediated EMT and stemness DICER1 TOLL LIKE RECEPTOR SIGNALING RELATED TO MYD88%WIKIPATHWAYS_20260610%WP3858%HOMO SAPIENS Toll like receptor signaling related to MyD88 REL MYD88 IKBKE RELB TLR4 MAPK1 NFKB1 NFKB2 IKBKB TBK1 IKBKG CHUK TICAM2 IRAK4 TICAM1 TIRAP TLR9 IRF3 TLR8 TLR5 RELA TRAF3 TLR3 TRAF6 IRF7 TLR7 TLR1 IRAK1 CYTOKINE CYTOKINE RECEPTOR INTERACTION%WIKIPATHWAYS_20260610%WP5473%HOMO SAPIENS Cytokine cytokine receptor interaction BMPR1A TNFRSF14 CXCL6 CXCL9 CSF2 CXCL8 CXCL17 CXCL1 CXCL13 CXCL3 CXCL2 TNF CXCL5 CCR6 IL6ST IL6R IL10 IFNAR2 IL1R2 IFNAR1 IL8RB IL9 IL9R CCL5 CCL4 CCL3 CCL2 IFNB1 PPBP IL6 CXCL11 MSTN CXCL12 PF4 IL13RA1 TGFBR1 LEPR CNTFR IL4 CNTF IL23R IL27RA IFNA2 TNFSF10 gdf7 ACVR1 IL15RA IL20RA IL20RB CCR10 PRL CCR1 XCR1 TNFSF14 TSLP TNFSF12 LIF GHB2 GDF1 IFNLR1 GDF3 GDF6 CSF3 GDF5 CSF3R IL22RA1 CD27 EPO NODAL ACVRL1 IL22 IL20 TNFRSF13B IL26 IL24 IL27 ANP32B TNFRSF13C CX3CL1 PRLR CCR8 CCR7 CCR5 CCR4 PF4V1 CCR2 CXCR4 IL11 TNFRSF12A IFNGR1 IFNGR2 IL19 IL17RC IL17RB GH1 IL17RA CCL14 CCL13 CCL11 IL7 CXCR5 CXCR6 CXCR1 TNLG7A IL7R CCL19 CCL18 IL12RB1 RELT GHR CCL15 GDF10 CCL25 IL33 CCL24 CCL23 IL31 CCL22 CCL21 IL3RA IL10RB ACKR3 IL10RA IL34 BMP8B CLCF1 TNLG8A INHA CCL27 IL18R1 CCL26 AMHR2 CCL4L2 EPOR MPL CXCL14 IL-21 CXCL16 IL18RAP TNFRSF8 IL13RA2 TNFRSF4 TNLG5A IL11RA TNLG2B CSF2RB CSF2RA TNFRSF17 TNFRSF9 TNFRSF10C INHBB TNFRSF10A INHBC IFNW1 BMP6 INHBE BMP3 BMP10 BMP15 AMH TNLG1B TNFRSF18 TNFRSF19 IFNK LTA XCL2 XCL1 TNFRSF25 LTB TNFRSF21 CX3CR1 IL1RL1 IFNL2 CCL8 IFNL1 ACVR1C CCL7 IL21R CCL1 IFNL3 ACVR2B ACVR2A ACKR4 TNFSF11 TNFRSF11B TGFBR2 ACVR1B IL1RN CSF1 IL36A IL36B IL23A IL1RL2 IL36RN IL37 IL36G IL2 IL1F10 NGF LTBR TNLG7C INHBA EDAR TNFRSF10B IL1R1 TNFRSF11A IL18 NGFR IFNG CCR3 GDF15 CSF1R TPO IL3 LEP CD40 IL5RA IL2RG TNFRSF1B IL5 CD40LG BMPR2 IL2RA IL2RB IL25 GDF11 CCL20 IL13 TGFB1 IL17F IL17D IL17C CCL28 BMP7 IL17B IL17A BMP5 BMP4 IL1A TNFSF6 TNFRSF1A REGULATORY CIRCUITS OF STAT3 SIGNALING%WIKIPATHWAYS_20260610%WP4538%HOMO SAPIENS Regulatory circuits of STAT3 signaling IFNLR1 MAPK10 CSF3R IL22RA1 DEPTOR MAPK8 AKT1S1 MAPK1 RICTOR MAPK3 TRIM28 IFNGR1 CTF1 IFNGR2 EGFR STAT3 IL6ST MAPK14 MTOR IL7R SETD7 IL6R GHR IFNAR2 TYK2 IL3RA IL10RB IFNAR1 IL10RA PDGFRA SOCS3 CREBBP JAK3 IL9R SRC MPL PTPRC PRKCB IL11RA CSF2RB CSF2RA DUSP2 MAPKAP1 MLST8 IL5RA IL2RG IL2RA IL2RB IL21R MAPK9 CNTFR MAPK7 PTPRT MAPK6 AGTR1 MAPK4 IL27RA AGTR2 MAPK15 F2RL3 IL15RA F2R OSMR RPTOR IL20RA MAPK12 IL20RB MAPK13 MAPK11 JAK1 F2RL2 NEURAL CREST CELL MIGRATION IN CANCER%WIKIPATHWAYS_20260610%WP4565%HOMO SAPIENS Neural crest cell migration in cancer PIK3CA PIK3R4 MMP2 PIK3R3 ARHA PAK1 TWIST1 SORT1 NTRK2 KIDINS220 STAT3 AKT3 TIAM1 JUN PIK3CD PAK6 PAK4 EPHB6 TRIO PIK3R5 EPHB2 ARF1 EPHB1 EPHB4 EPHB3 NGFR BDNF CDH11 F2RL2 MMP9 RAC1 FOS INTERLEUKIN 1 INDUCED ACTIVATION OF NF KB%WIKIPATHWAYS_20260610%WP3656%HOMO SAPIENS Interleukin 1 induced activation of NF kB HEL-S-71 TIFA NFKB1 UBE2V1 AJUBA PRKCZ SQSTM1 IL1A IRAK1 TRAF6 MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY%WIKIPATHWAYS_20260610%WP1544%HOMO SAPIENS MicroRNAs in cardiomyocyte hypertrophy HDAC5 RCAN1 CDK7 PIK3CA PLCB2 ARHA MAPK8 MAPK1 CAMK2D MAPK3 CTF1 TNF STAT3 IKBKB IL6ST MAPK14 IKBKG MTOR CHUK PIK3CD MYLK3 MYLK MAP2K3 WNT3A CDK9 EDN1 FGF2 MAP2K6 IGF1R MAP2K4 PRKCB FGFR2 IKBKE PDPK1 PPP3CA EGF MAP2K5 MAP2K1 GSK3B MAP2K2 GATA4 NFATC4 PIK3R3 PIK3R2 IGF1 PIK3R1 NFKB1 MAP3K14 RAF1 NRG1 MAP3K7IP1 ROCK1 ROCK2 MYEF2 MAPK7 TGFB1 CALM1 MAPK4 LRP5 NPPB LRP6 NPPA PRKG1 CISH HDAC7 DVL1 FZD1 EIF2B5 RAC1 FZD2 LIF PLA2G2A ACETAMINOPHEN IN ANALGESIA AND ANTIPYRESIS%WIKIPATHWAYS_20260610%WP5444%HOMO SAPIENS Acetaminophen in analgesia and antipyresis FAAH TRPA1 HTR1A TRPV1 KCNQ2 KCNQ3 PTGS2 CACNA1H PTGS1 VISUAL CYCLE%WIKIPATHWAYS_20260610%WP5534%HOMO SAPIENS Visual cycle RDH10 RDH8 ABCA4 RLBP1 RPE65 OPN1SW OPN1MW RDH12 OPN1LW RBP3 RDH11 RBP1 RHO RDH5 LRAT SNARE COMPLEX MACHINERY IN EXOCYTOSIS%WIKIPATHWAYS_20260610%WP5621%HOMO SAPIENS SNARE complex machinery in exocytosis GDI1 RPH3A STXBP1 UNC13A VAMP2 NAPA SYT1 SYP CPLX1 STX1B RIMS1 CACNA1B STXBP5 CACNA1A STXBP6 SNAP25 DNA IR DAMAGE AND CELLULAR RESPONSE VIA ATR%WIKIPATHWAYS_20260610%WP4016%HOMO SAPIENS DNA IR damage and cellular response via ATR ABRAXAS1 BRCC3 TRIM28 DCLRE1A MDC1 SMARCAL1 FEN1 UBE2D3 CEP164 HERC2 MRE11A TOPBP1 RMI1 IKBKG TOP3A RECQL RAD50 HUS1 EEF1E1 MCPH1 XPA RNF8 PPM1D RECQL4 BRIP1 WRN RBBP8 CLSPN TP53BP1 POLN XRCC5 SHFM1 USP1 FANCA PALB2 CLK2 BCL6 RFWD3 TDP1 BRCA2 CHEK2 CHEK1 H2AX PCNA SMARCC2 CDC45 MSH2 NBN RPA1 SMC1A PRKDC FANCD2 BARD1 PLK1 ATRIP CDC2 SP1 UIMC1 PML CDK2 RAD52 MDM2 RAD51 ATM RAD17 ATR FOXM1 RAD1 MCM2 RAD9A BRCA1 MODULATORS OF TCR SIGNALING AND T CELL ACTIVATION%WIKIPATHWAYS_20260610%WP5072%HOMO SAPIENS Modulators of TCR signaling and T cell activation RASA2 GNA13 IKBKB IKBKG CHUK RELA TRAF6 VAV1 ZAP70 LCK SOCS1 ITK DGKA TNFAIP3 TMEM222 GRAP2 ARIH2 UBASH3A DGKZ PLCG1 REL LCP2 PTPN6 CARD11 PDPK1 NDUFB10 CD3G CUL5 PRKCQ RNF7 CD3E MAP3K8 BCL10 RPRD1B CD8A SH2B3 MEF2D SH2D1A ARHH FIBP CD5 AGO1 LAT PIK3R2 PIK3R1 NFKB1 MAP3K14 NFKBIA GRB2 CDKN1B CD3D MAP4K1 GLP 1 FROM INTESTINE AND PANCREAS AND ROLE IN GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260610%WP5452%HOMO SAPIENS GLP 1 from intestine and pancreas and role in glucose homeostasis PCSK2 PCSK1 GCG GLP1R INS REGULATION OF WNT B CATENIN SIGNALING BY SMALL MOLECULE COMPOUNDS%WIKIPATHWAYS_20260610%WP3664%HOMO SAPIENS Regulation of Wnt B catenin signaling by small molecule compounds CSNK1A1 LEF1 GSK3B TNKS FZD7 AXIN1 MBOAT1 FZD8 DKK3 SFRP4 APC DVL2 FZD1 TCF4 WNT1 COHESIN COMPLEX CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260610%WP5117%HOMO SAPIENS Cohesin complex Cornelia de Lange syndrome HDAC8 APC CDCA5 SMC1A PDS5B PPP2R1B PDS5A AURKB PPP2R1A NIPBL SGOL1 PPP2CA PTTG1 WAPAL ESCO1 PLK1 ESCO2 REC8 CDC2 SMC1B MAU2 STAG2 PPP2R5E STAG3 PPP2R5B ESPL1 PPP2R5A PPP2R5D PPP2R5C PTPA SMC3 RAD21 NICOTINE METABOLISM IN LIVER CELLS%WIKIPATHWAYS_20260610%WP1600%HOMO SAPIENS Nicotine metabolism in liver cells UGT1A4 CYP2A6 CYP2B6 UGT1A9 AOX1 ARSENIC METABOLISM AND REACTIVE OXYGEN SPECIES GENERATION%WIKIPATHWAYS_20260610%WP5233%HOMO SAPIENS Arsenic metabolism and reactive oxygen species generation ATP1A1 SDHA COA3 AS3MT HEL-S-21 UQCRFS1 ND1 HEL-S-44 NICOTINE EFFECT ON DOPAMINERGIC NEURONS%WIKIPATHWAYS_20260610%WP1602%HOMO SAPIENS Nicotine effect on dopaminergic neurons GNB1 DDC DRD2 CHRNB2 CDK5 TH CHRNA3 KCNK9 CHRNA5 CHRNA6 GNG2 PPP1R1B DRD3 SLC18A2 DRD4 KCNK3 GNAI1 PYRIMIDINE METABOLISM AND RELATED DISEASES%WIKIPATHWAYS_20260610%WP4225%HOMO SAPIENS Pyrimidine metabolism and related diseases DPYS HEL74 OTC TYMP CAD ABAT RRM1 RRM2 DPYD DHODH UMPS AGXT2 TYMS NT5C3A RRM2B GLS2 TARGETED AGENTS IN TRIPLE NEGATIVE BREAST CANCER%WIKIPATHWAYS_20260610%WP5215%HOMO SAPIENS Targeted agents in triple negative breast cancer PIK3CA SOS1 DEPTOR MAP2K1 MAPKAP1 MAP2K2 PIK3R1 TSC2 TSC1 NRAS MAPK1 AKT1S1 RICTOR MLST8 MAPK3 RAF1 ARAF AKT3 EIF4EBP1 MTOR SOS2 IRS1 GRB2 PTEN RPTOR HRAS PARP2 INPP4B RPS6KB1 CANONICAL AND NON CANONICAL NOTCH SIGNALING%WIKIPATHWAYS_20260610%WP3845%HOMO SAPIENS Canonical and non canonical Notch signaling MAML2 NOTCH4 NOTCH2 RBPJ JAG2 CHUK DLK2 NOTCH1 DNER MFAP2 MAML3 DLL3 DLL4 PSEN2 PSEN1 LEF1 HES1 MAML1 ADAM10 MFAP1 NOTCH3 RRAS PEROXIREDOXIN 2 INDUCED OVARIAN FAILURE%WIKIPATHWAYS_20260610%WP4873%HOMO SAPIENS Peroxiredoxin 2 induced ovarian failure MAPK10 STAR BAX HEL-S-2a HSD3B2 CASP3 PARP2 CYP11A1 NAD METABOLISM IN ONCOGENE INDUCED SENESCENCE AND MITOCHONDRIAL DYSFUNCTION ASSOCIATED SENESCENCE%WIKIPATHWAYS_20260610%WP5046%HOMO SAPIENS NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence MDH2 HMGA1 GOT2 IL6 SIRT5 NMNAT2 ELAVL1 SIRT2 SIRT3 RELA NAMPT IL1B PRKAA1 SLC2A4 CCL27 SIRT1 HEL-S-32 SMITH MAGENIS AND POTOCKI LUPSKI SYNDROME COPY NUMBER VARIATION%WIKIPATHWAYS_20260610%WP5381%HOMO SAPIENS Smith Magenis and Potocki Lupski syndrome copy number variation IFT74 CREB1 RMND5A PRKAA1 RANBP9 MKLN1 NR1H2 GID4 TNF RMI1 TOP3A CLUAP1 BCL2L11 BCL6 FOXA1 HEL-S-133P APP MYC PRKAB1 TRAF3IP1 PCK1 G6PC1 HES6 MAP3K14 BLM RRAGA PRKAG2 JUN MYH2 CDC2 COPS8 CLTC CLTB PTEN CLTA NR1H3 RPTOR IFT172 MYD88 MAEA IFT80 ARMC8 ITPK1 TNFRSF13B IFT81 ATG101 FHOD1 IL1B PARK2 ARHA FERD3L IRF8 ALKBH5 CFL2 DENR MIGA1 MED9 RNF41 TOM1L2 COPS7A PARD3 LLGL1 DRC5 DRC7 DRC8 FLII STAT3 GPR85 CLEC16A PLD6 RAI1 WWTR1 MTOR TNFSF13 RAB39B BAX PEMT DRC1 GDI2 WDR41 FLCN ATPAF2 ARG2 RMI2 DRC10 RELA SMCR8 COPS4 C9orf72 IFT20 GPS1 COPS6 MIEF2 IFT22 PARD6B RASD1 COPS5 FNIP1 FNIP2 PPP1R14A LIMK1 MYO16 RAB10 IFT27 MYO15A CARM1 IFT25 PER1 DRG2 FOXA2 TTC26 PRKCI CRY2 CRY1 SHMT1 IFT52 IFT57 TLR4 RAB8A NFKB1 RB1CC1 MLST8 TFEB ULK1 BIRC2 ROCK1 GRIP1 IFT46 ETV5 YAP1 IFT70B WDR26 G13 SIGNALING%WIKIPATHWAYS_20260610%WP524%HOMO SAPIENS G13 signaling WAS MAPK10 CYFIP1 WASL PKN1 SH3RF1 PIP4K2A PIK3CA RHPN2 MYBPH CIT MYL1 PFN1 CDC42 TNK2 HEL-S-15 ARHA PIK3R2 GNA13 CFL2 IQGAP1 ROCK1 ROCK2 ARHGEF1 PIK3CD CALM1 ARHGDIB HEL-S-80p LIMK1 RTKN RAC1 ARHGDIG RPS6KB1 EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20260610%WP581%HOMO SAPIENS EPO receptor signaling EPO SOS1 PTPRU IRS1 MAP2K1 MAP2K2 GRB2 SHC1 STAT5B MAPK1 SOCS1 MAPK3 SRC RAF1 CISH STAT1 STAT3 EPOR PTPRC SPINAL CORD INJURY%WIKIPATHWAYS_20260610%WP2431%HOMO SAPIENS Spinal cord injury NTN1 EGR1 CXCL8 CXCL1 CXCL2 TNF PLA2G5 EPHA4 IL2 ACAN SOX9 FKBP1A EFNB2 CCL2 RB1 IL6 CCND1 MYC MMP12 CDC2 GADD45A CDK4 CDK2 IL4 CDKN1B IL1R1 GRIN1 NGFR BDNF CASP3 IFNG RHOB HEL113 RAC1 FOS PLA2G6 CDC42 IL1B ARHA MAPK1 CCR2 MAPK3 EGFR MBP TNFSF13 TNLG7A GJA1 COL4A1 MMP9 CCNG1 PRKCA PPP3CA XYLT1 AQP4 AQP1 ZFP36 SEMA6A OMG PDYN BCAN RTN4R KLK8 CHST11 PLXNA2 TLR4 GFAP SELP NOX4 CSPG4 FOXO3A BTG2 LEP NCAN PRB1 PRB2 ANXA1 RGMA COL2A1 VCAN ROS1 GAP43 LTB CD47 C1QB AIF1 SLIT1 SLIT3 NOS2 ROCK2 SLIT2 E2F5 RTN4 LILRB3 FCGR2A APEX1 ARG1 TGFB1 TACR1 IL1A PTGS2 GDNF LTB4R PLA2G2A IRON METABOLISM IN PLACENTA%WIKIPATHWAYS_20260610%WP2007%HOMO SAPIENS Iron metabolism in placenta HAMP SLC11A2 HEL60 TF HEPHL1 TFRC STEAP3 TFR2 IREB2 SLC40A1 MCOLN1 PHOTODYNAMIC THERAPY INDUCED HIF 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260610%WP3614%HOMO SAPIENS Photodynamic therapy induced HIF 1 survival signaling PDHA1 EPO HEL-S-133P HEL-S-68p PFKL TGFA HIF1AN BIRC5 BNIP3 SLC2A3 PMAIP1 NOS2 BAX BCL2A1 BAK1 EGLN1 IGFBP1 BNIP3L IGFBP2 ANGPT1 HEL-S-30 EDN1 ANGPT2 HIF1A PTGS2 VEGFA BCL2L1 MCL1 LAC PHE PATHWAY%WIKIPATHWAYS_20260610%WP5239%HOMO SAPIENS Lac Phe pathway ABCC5 CNDP2 OMEGA 9 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260610%WP4724%HOMO SAPIENS Omega 9 fatty acid synthesis SCD FASN FADS2 ELOVL5 FADS1 ELOVL1 ELOVL2 SCD5 ELOVL3 ACSL1 ELOVL6 FACL4 ACSL3 PATHOGENIC ESCHERICHIA COLI INFECTION%WIKIPATHWAYS_20260610%WP2272%HOMO SAPIENS Pathogenic Escherichia coli infection WAS TUBA3E WASL TUBA1C TUBB6 TUBA1B TUBA1A PRKCA EZR HEL-S-93 TUBB1 TUBB ARPC4 CDC42 ARPC5 HEL-68 TUBB4B TUBB4A TUBA4A ITGB1 TUBB2A YWHAQ KRT18 ARHA ARPC2 ARPC3 NCK2 TUBA2 NCK1 HCLS1 ARHGEF2 TLR4 TUBA8 NCL ROCK1 ROCK2 CLDN1 TLR5 ACTG1 CD14 PS1TP5BP1 FYN TUBAL3 ARPC1B LY96 TUBB8 SLC25A46 PATHWAY%WIKIPATHWAYS_20260610%WP5521%HOMO SAPIENS SLC25A46 pathway EMC1 EMC2 EMC3 MFN1 MFN2 EMC6 EMC7 OPA1 APOOL MMGT1 IMMT TMEM85 COX4NB EMC10 MICOS13 MICOS10 APOO CHCHD3 CHCHD6 DISORDERS IN KETONE BODY SYNTHESIS%WIKIPATHWAYS_20260610%WP5175%HOMO SAPIENS Disorders in ketone body synthesis HMGCL BDH1 OXCT1 ACAT1 SYNTHESIS OF CERAMIDES AND 1 DEOXYCERAMIDES%WIKIPATHWAYS_20260610%WP5194%HOMO SAPIENS Synthesis of ceramides and 1 deoxyceramides SPHK1 SGMS2 UGCG DES KDSR CERS3 CERS5 SPTLC1 CERS2 CERS6 DGAT1 CERK SGMS1 LASS1 UGT8 B4GALT1 B3GNT5 B4GALNT1 A4GALT A3GALT2 AKT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260610%WP5531%HOMO SAPIENS AKT signaling and ARTD family members PIK3CA PIK3R4 GSK3B MAPKAP1 PIK3R3 STK11 PIK3R2 PIK3R1 TSC2 FOXO1 TSC1 RICTOR MLST8 AKT3 IKBKG MTOR PIK3CD ATM PIK3R5 PARP3 RPTOR PHLPP1 PIK3C2G SIRT1 PARP2 PIK3C2B 8Q11 23 RB1CC1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260610%WP5412%HOMO SAPIENS 8q11 23 RB1CC1 copy number variation GABARAP RB1 TRAF2 MAP3K5 ATG16L1 ATG101 GABARAPL2 RB1CC1 PTK2B WDR45B GABARAPL1 ULK1 TNF PDGFR BETA PATHWAY%WIKIPATHWAYS_20260610%WP3972%HOMO SAPIENS PDGFR beta pathway MAP2K4 PRKCB PLCG1 JUN PIK3CA PRKCA SOS1 EIF2AK2 MAP2K1 GRB2 SHC1 MAPK8 STAT5B PIK3R1 MAPK3 RAF1 HRAS STAT1 JAK1 MAP3K1 STAT3 FOS T CELL ANTIGEN RECEPTOR TCR PATHWAY DURING STAPHYLOCOCCUS AUREUS INFECTION%WIKIPATHWAYS_20260610%WP3863%HOMO SAPIENS T cell antigen receptor TCR pathway during Staphylococcus aureus infection PIK3CA SOS1 PAK1 CSF2 MAPK3 TNF CTLA4 IKBKB RRAS IKBKG CHUK IL10 IL2 ZAP70 LCK PDCD1 CBL CHP1 AHSA1 ITK FYN ICOS GRAP2 PTPRC PLCG1 LCP2 PTPN6 CARD11 NFATC2 PRKCQ MAP3K8 BCL10 CD8A MAP2K1 GSK3B MAP2K2 LAT NCK1 NFKB1 MAP3K14 RAF1 DAG1 IL5 CD40LG JUN CDK4 MAPK9 IL4 NFKBIA GRB2 CALM1 MAP3K7 CD3D IFNG FOS GNAQ P R183Q DRIVES CAPILLARY MALFORMATION%WIKIPATHWAYS_20260610%WP5501%HOMO SAPIENS GNAQ p R183Q drives capillary malformation PRKCB RCAN1 PPP3CC PPP3R2 PRKCI PKN1 PRKCH PRKCE NFATC1 PRKCA PLCB3 PKN2 PRKCQ PRKCZ PPP3R1 PRKD3 PPP3CA PRKD1 ANGPT2 PKN3 PRKD2 NOTCH SIGNALING%WIKIPATHWAYS_20260610%WP61%HOMO SAPIENS Notch signaling MAML2 CIRSR NOTCH4 SKP1 RBPJ HES5 SPEN JAG2 RING1 NOTCH1 ITCH SNW1 PSENEN MAML3 DLL3 DLL4 PSEN2 SAP30 PSEN1 GSK3B PIK3R2 HES1 PIK3R1 NFKB1 HES6 NCOR2 NCOR1 STAT3 ADAM17 NOTCH2 MTOR EP300 MAML1 FBXW7 LCK HDAC2 NUMB SRC FHL1 HDAC1 DTX1 APH1B HEY2 NOTCH3 MAGEA1 KISSPEPTIN KISSPEPTIN RECEPTOR SYSTEM IN THE OVARY%WIKIPATHWAYS_20260610%WP4871%HOMO SAPIENS Kisspeptin kisspeptin receptor system in the ovary PRKCB PRKCH PIK3CA PRKCA PLCB3 PLCB4 PRKCQ KISS1R KISS1 FSHR PLCB1 MAP2K1 PLCB2 MAP2K2 NRAS MAPK1 NFKB1 BMP15 AMH MAPK3 DKFZp686L0365 RAF1 HSD3B1 CYP11A1 STAR PRKCE PIK3CD HRAS MMP9 AMPK REGULATION OF MAMMARY MILK PROTEIN SYNTHESIS%WIKIPATHWAYS_20260610%WP5492%HOMO SAPIENS AMPK regulation of mammary milk protein synthesis MTOR EIF4A2 PRKAA2 CSN3 EEF2K PRKAB2 CSN2 CSN1S1 EEF2 PRKAB1 EIF4G1 PRKAA1 TSC2 RPTOR MLST8 EIF4E PRKAG1 PRKAG2 PRKAG3 RPS6KB1 GASTRIC CANCER NETWORK 1%WIKIPATHWAYS_20260610%WP2361%HOMO SAPIENS Gastric cancer network 1 TOP2A NOTCH1 INO80D NUP107 UBE2C H4C9 HCTP4 H3F3B LIN9 GATD3 AURKA KIF15 SMOC2 CENPF ESM1 RUVBL1 APC S100P CEP192 MYBL2 ECT2 ACTL6A KIF20B E2F7 NON SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260610%WP4255%HOMO SAPIENS Non small cell lung cancer RARB PIK3CA SOS1 KIF5A RXRA MAPK1 E2F3 MAPK3 EGFR BAD ARAF CDKN2A STAT3 AKT3 BAX SOS2 PIK3CD STAT5B JAK3 STK4 PRKCB PLCG1 PDPK1 PRKCA RB1 RASSF1 CCND1 ERBB2 EGF PLCG2 MAP2K1 MAP2K2 TGFA HGF E2F2 NRAS FOXO3A RAF1 DDB2 ALK RET POLK HEL-S-61 EML4 CRABP2 CRABP1 FHIT RXRB GADD45B RXRG GADD45A CDK4 GADD45G CDK6 GRB2 BAK1 CYCS CDKN1A CASP9 CASP8 CASP3 HRAS 16P12 2 COPY NUMBER VARIATION SYNDROME 520KB %WIKIPATHWAYS_20260610%WP5510%HOMO SAPIENS 16p12 2 copy number variation syndrome 520kb COX5A NDUFA9 PRKAA1 MAPK1 MAPK3 CDR2 MAPK14 MTOR POLR3E RPS6KB1 RPS6KA1 EEF2K PRKAB2 MAP2K1 PRKAB1 EEF2 MAP2K2 MLST8 PRKAG1 PRKAG2 PRKAG3 CDC2 COX7C CYB PRKAA2 RAB5IF MOSMO CDK2 NDUFS8 UQCRC1 UQCRFS1 NDUFS3 COXFA4 CALM1 UQCRC2 CDH18 UQCRB UQCR11 UQCR10 UQCRH RPTOR TRPM7 MAPK12 CYC1 MAPK13 PDZD9 MAPK11 SDR42E2 VWA3A UQCRQ NRP1 TRIGGERED SIGNALING IN PANCREATIC CANCER %WIKIPATHWAYS_20260610%WP5144%HOMO SAPIENS NRP1 triggered signaling in pancreatic cancer REL PECAM1 TGFBR2 RELB EGF MMP2 MAP2K1 COL1A1 MAP2K2 COL1A2 HGF PLXNA2 MAPK1 NFKB1 TGFBR1 NFKB2 MAPK3 NRP1 GSK3A EGFR CCNE2 AKT3 CCNE1 SMAD2 CDK2 RELA CTGF SNAI1 SNAI2 CDKN1B FLT1 CHD2 SRC SMAD4 SEMA3A MMP9 PLXNA1 VEGFA KDR RAC1 PLXNA4 TGFBR3 GASTRIN SIGNALING%WIKIPATHWAYS_20260610%WP4659%HOMO SAPIENS Gastrin signaling EGR1 CREB1 ITGB1 CXCL8 TJP1 DKFZp686L0365 IRS1 PRKD1 IL2 FYN PRKD2 BCL2L1 RPS6KB1 CCND1 MEF2D MYC MAP2K1 MMP7 SHC1 MEF2C ATF2 MAP3K11 RPS6 RAF1 PXN EIF4EBP1 PRKCE JUN SP1 CLDN1 MAPK9 NFKBIA GRB2 CDKN1A CDKN1B CASP3 HRAS RHOB RAC1 FOS KAT5 MEF2B ARHGEF28 PIK3CA YES1 SERPINB2 SOS1 ANXA2 CRK RHOD CD44 CDC42 HDC ELAVL1 KLF4 ARHA MAPK8 PAK1 MAPK1 MAPK3 CCKBR EGFR BAD CDKN2A TCF4 STAT3 IKBKB PTPN11 MAPK14 MTOR LAMTOR3 CHUK KIT RELA SRC VEGFA PLCG1 PRKCH PRKCA PRKCQ GAST GSK3B PIK3R3 PIK3R2 PIK3R1 BIRC5 FOXO1 SLC9A3 NFKB1 FOXO3A PPARG BIRC2 BIRC3 ROCK1 BMP2 HDAC7 PTGS2 TFF2 BURN WOUND HEALING%WIKIPATHWAYS_20260610%WP5055%HOMO SAPIENS Burn wound healing PECAM1 S100A9 MYD88 KLF4 FOXE1 HEXD F13A1 KRT222 IL1B S100A6 PCTK1 FLG TAGLN BRD4 AMBP CXCR4 HEL-S-43 CXCL8 SLURP1 LIN28A TPT1 CXCL1 FBN1 TNF BAX TNC HMGB1 ACHE IL8RB CCL2 MMP9 INHBA VEGFA FGFR4 IFNB1 FGFR2 CD3E IL6 EGF MMP2 CXCL12 MMP28 COL1A1 FGFR1 COL1A2 HGF TLR4 NFKB1 NOX4 CHRNA7 FGFR3 SCEL BCL2 KRT6A SNAI2 IFNA2 FST DCN CASP3 ACTA1 TIMP1 11P11 2 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260610%WP5348%HOMO SAPIENS 11p11 2 copy number variation syndrome CRY2 ITGA6 HBEGF REST HLA-DMA HLA-DMB CD63 ITGB1 ITGA4 NRXN1 LGALS3BP IGSF8 CD151 CD82 SPPL2C PRDM11 ACCS PHF21A ALKBH3 C11orf96 ALX4 TP53I11 GLI3 LARGE2 CD19 PEX16 CHST6 SHH IZUMO1 SLC35C1 SYT13 LEF1 EXT1 VANGL1 EXT2 FREY1 SLC25A17 MAPK8IP1 B4GAT1 B3GNT7 PEX3 TSPAN18 CHST1 MS4A1 B4GALT4 SDCBP TIMP1 DISORDERS OF NAD METABOLISM%WIKIPATHWAYS_20260610%WP5506%HOMO SAPIENS Disorders of NAD metabolism BST1 NAXE NAXD NADSYN1 SELECTIVE EXPRESSION OF CHEMOKINE RECEPTORS DURING T CELL POLARIZATION%WIKIPATHWAYS_20260610%WP4494%HOMO SAPIENS Selective expression of chemokine receptors during T cell polarization IL5 CD40LG CCR3 IL12RB1 IL12B IL12A IL2 IL4 TGFB1 CCR7 CCR5 CCR4 CSF2 CXCR4 CCR2 IFNGR1 CCR1 IFNGR2 CCL4 CCL3 IL18R1 IFNG CXCR3 NUCLEOTIDE EXCISION REPAIR%WIKIPATHWAYS_20260610%WP4753%HOMO SAPIENS Nucleotide excision repair GTF2H2C_2 LIG1 CDK7 RFC2 GTF2H2 POLE GTF2H3 GTF2H4 GTF2H5 RFC3 RBX1 RFC4 CUL4A DDB1 ERCC1 ERCC2 ERCC5 MNAT1 PCNA RPA1 RFC1 RPA3 DDB2 POLD3 POLD4 POLD2 CUL4B XPA POLE4 POLE2 POLE3 CCNH CETN2 XPC POLYCYSTIC KIDNEY DISEASE PATHWAY%WIKIPATHWAYS_20260610%WP2571%HOMO SAPIENS Polycystic kidney disease pathway CFTR GNAS VEGFB STK11 PRKAA1 MAPK3 DVL3 SLC12A2 TNF IKBKB GNAI1 PRKACG MTOR PDE1A WNT3A GNAI3 ADCY6 FLT1 SRC IGF1R KDR RPS6KA1 CCND1 ERBB2 EGF PLCG2 MYC PRKAB2 GSK3B PRKAB1 WNT2B MAP2K2 FZD10 PKD1 IGF1 WNT5B WNT9B TSC2 TSC1 WNT9A WNT16 NRAS FZD7 WNT8A WNT8B KCNN4 FZD8 WNT3 SFRP4 WNT4 DVL2 WNT10B WNT10A FZD3 PRKAG1 FZD5 PRKAG2 FZD4 PRKAG3 WNT7B FZD9 WNT7A JUN GNA11 RHEB PRKAA2 HRAS SSTR2 DVL1 FZD1 WNT1 FZD2 FOS ROBO4 AND VEGF SIGNALING CROSSTALK%WIKIPATHWAYS_20260610%WP3943%HOMO SAPIENS ROBO4 and VEGF signaling crosstalk ROBO4 SLIT2 SRC VEGFA KDR RAC1 CONGENITAL GENERALIZED LIPODYSTROPHY%WIKIPATHWAYS_20260610%WP5101%HOMO SAPIENS Congenital generalized lipodystrophy CAVIN1 PIK3CA BSCL2 HMFN0839 LPIN2 LPIN3 IRS1 INS DGAT1 GRB2 ITGB4 FYN LPIN1 HIF1A DGAT2 WNT SIGNALING AND PLURIPOTENCY%WIKIPATHWAYS_20260610%WP399%HOMO SAPIENS Wnt signaling and pluripotency MAPK10 NFYA AXIN2 CD44 ARHA CTBP2 APC DVL3 NR1C2 EP300 PPP2R5E PRKD1 LDLR LEF1 PPP2R5C WNT3A PTPA TCF7L2 TCF7L1 hCG_2014051 CREBBP NLK PPP2R3B PPP2R3A FOSL1 PPP2R2C PPP2R2B MAP2K4 PRKCB PRKCI PRKCH PRKCA PRKCQ LRRK2 PRKCZ CCND1 MYC SOX2 GSK3B WNT2B FZD10 MMP7 WNT5B WNT9B CCND3 CCND2 WNT16 FZD7 AXIN1 FZD8 WNT3 PPP2R2A WNT4 DVL2 WNT10B WNT10A PPP2R1B FZD3 FZD5 PPP2R1A FZD4 WNT7B FZD9 PPP2CA WNT7A PRKCE JUN CTNND1 FRAT1 FOXD3 ZBTB33 CTBP1 PPM1J MAPK9 NKD1 NKD2 ESRRB PAFAH1B1 LRP5 MAP3K7 LRP6 POU5F1 DVL1 FZD1 WNT1 FZD2 NEPHROGENESIS%WIKIPATHWAYS_20260610%WP5052%HOMO SAPIENS Nephrogenesis NOTCH2 FGF8 SIX2 WNT3A FOXD1 OSR1 WNT9B GREB1L BMP7 TCF21 MEIS1 PAX2 ALDH1A2 FGF20 RSPO3 RSPO1 WNT4 RENIN ANGIOTENSIN SYSTEM AND BRADYKININ PATHWAYS IN COVID 19%WIKIPATHWAYS_20260610%WP4969%HOMO SAPIENS Renin Angiotensin System and Bradykinin pathways in COVID 19 ROCK1 NR1i1 CYP3A4 ACE2 REN IL1B CPN1 ARHA AGTR1 AGTR2 MAPK1 NFKB1 CYP24A1 KLK1 PRKG1 KNG1 IL1A BDKRB2 BDKRB1 TNF SERPING1 KLKB1 IL23 INHIBITORS IN INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260610%WP5516%HOMO SAPIENS IL23 inhibitors in inflammatory bowel disease IL12RB1 IL22 IL12B TYK2 IL17F STAT5B TLR4 CSF2 IL17A STAT4 STAT1 IFNG IL23A STAT3 TNF RORC HEROIN METABOLISM%WIKIPATHWAYS_20260610%WP2645%HOMO SAPIENS Heroin metabolism BCHE CES2 CES1 CYTOPLASMIC RIBOSOMAL PROTEINS%WIKIPATHWAYS_20260610%WP477%HOMO SAPIENS Cytoplasmic ribosomal proteins HEL-S-310 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL13a RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RPL36 RPL35 RPLP2 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS3A RPSA RPL37A RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 MRPL19 RPL11 RPL36A RPS4Y1 RPS6KB2 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPS27A RPS6KB1 RPL17 RPL19 RPS6KA6 RPL41 RPL35A RPS6KA2 RPL23A RPS6KA1 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPS6 IL2 SIGNALING%WIKIPATHWAYS_20260610%WP49%HOMO SAPIENS IL2 signaling SOS1 CRKL MAP2K1 MAP2K2 SHC1 NMI PIK3R1 MAPK1 PTK2B MAPK3 FOXO3A RPS6 RAF1 STAT1 IL2RG STAT3 PTPN11 IL2RA IL2RB IL2 GRB2 GAB2 STAT5B LCK SYK CBL SOCS3 JAK3 RPS6KB2 FYN HRAS CISH JAK1 RPS6KB1 ANGIOGENESIS OVERVIEW%WIKIPATHWAYS_20260610%WP1993%HOMO SAPIENS Angiogenesis overview SOS1 CRK CDC42 PLXND1 MAPK8 PAK1 MAPK1 PTK2B IQGAP1 BAD APC PTPN11 MAPK14 MTOR PIK3CD VHL ANGPT1 SRC MMP9 MAP2K6 VEGFA KDR MAP2K4 WAS PLCG1 PDPK1 PRKCA FRS2 MMP2 MAP2K1 FGFR1 TIMP4 SHC1 SHB NCK1 ROBO1 GRB14 MMP14 GRB7 PLA2G1B NOX4 BMX ATF2 RAF1 NRP1 PXN DAG1 ROBO4 SLIT2 GRB2 MAP3K7 F2 MAPK11 SEMA3A RAC1 GLUCURONIDATION%WIKIPATHWAYS_20260610%WP698%HOMO SAPIENS Glucuronidation UGT1A4 UGT2B4 PGM2 UGT1A3 PGM5 UGT2A2 UGT1A1 UGT2A1 UGT2B7 UGT1A9 UGT1A8 UGT1A7 UGT1A10 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGDH UGT1A5 PGM3 MULTIPLE SCLEROSIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260610%WP5540%HOMO SAPIENS Multiple sclerosis mechanism and therapies ITGA4 S1PR1 BTK MS4A1 HEL-S-171mP S1PR3 S1PR5 S1PR4 ITGB1 ARYL HYDROCARBON RECEPTOR PATHWAY%WIKIPATHWAYS_20260610%WP2873%HOMO SAPIENS Aryl hydrocarbon receptor pathway CYP1A2 UGT1A1 NQO1 SERPINB2 CYP1A1 CYP1B1 NCOA1 IL1B HES1 NFE2L2 SLC7A5 EGFR TNF UGT1A4 POLK UGT1A3 CDC37 JUN EP300 BAX UGT1A9 MGST1 UGT1A7 AHR IL12B IL12A CAP2 PTGES3 MYOF IL2 TGFB1 AIP ALDH3A1 AHRR IGFBP1 CES3 CDKN1B JUNB IL17B JUND SRC IFNG METABOLIC REPROGRAMMING IN PANCREATIC CANCER%WIKIPATHWAYS_20260610%WP5220%HOMO SAPIENS Metabolic reprogramming in pancreatic cancer PDHA1 GOT2 HEL-S-133P GPT RPIA GLUD1 PFKL SLC7A5 GNPNAT1 GLS2 PGM3 ACLY HMGCR FASN HK2 LDLR DLAT GFPT1 SOAT1 RPE SLC16A4 DLD PDHX CS BCAT2 HEL-S-30 CARM1 HEL-S-32 ME1 OCTADECANOID FORMATION FROM LINOLEIC ACID%WIKIPATHWAYS_20260610%WP5324%HOMO SAPIENS Octadecanoid formation from linoleic acid CYP1A2 ALOX15 GPX4 CYP4A11 CYP3A4 EPHX3 ALOX12B PTGS2 ALOXE3 CYP2C19 PTGS1 CYP2C9 GNAQ PATHWAYS IN PORT WINE STAIN%WIKIPATHWAYS_20260610%WP5437%HOMO SAPIENS GNAQ pathways in port wine stain MAP2K4 MTOR PIK3CA MAP2K5 MAP2K3 MAP2K1 MAP2K2 ARHA TRIO MAPK1 NFKB1 YAP1 MAPK3 RAF1 MAP2K6 AMOT RAC1 KILLER CELL IMMUNOGLOBULIN LIKE RECEPTORS AND HUMAN LEUKOCYTE ANTIGEN C PATHWAY%WIKIPATHWAYS_20260610%WP5576%HOMO SAPIENS Killer cell immunoglobulin like receptors and human leukocyte antigen C pathway TYROBP PLCG1 PTPN6 LCP2 CD34 PRKCA PRKCQ GRB2 LAT VAV1 SYK CSF2 HLA-C FYN HRAS IFNG TNF KIR2DL1 RAC1 KIR2DL3 TARGET OF RAPAMYCIN SIGNALING%WIKIPATHWAYS_20260610%WP1471%HOMO SAPIENS Target of rapamycin signaling PRR5 DDIT4L PRKCA DDIT4 CDC42 PRKAB2 PRKAB1 ULK2 MAPKAP1 PRKAA1 TSC2 TSC1 AKT1S1 RICTOR MLST8 ULK1 RRAGA PRKAG1 RRAGB PRKAG2 RRAGD PRKAG3 EIF4EBP1 MTOR HMGCR RHEB PRKAA2 RPTOR FKBP1A RAC1 RPS6KB1 SREBF AND MIR33 IN CHOLESTEROL AND LIPID HOMEOSTASIS%WIKIPATHWAYS_20260610%WP2011%HOMO SAPIENS SREBF and miR33 in cholesterol and lipid homeostasis MTOR SIRT6 SCD HMGCR MED15 FASN SREBF2 LDLR ABCA1 PRKAA1 HMGCS1 NR1H3 PPARGC1A NR1C1 SIRT1 NSAIDS MECHANISM OF ACTION%WIKIPATHWAYS_20260610%WP5513%HOMO SAPIENS NSAIDs mechanism of action PTGS2 PTGS1 AEROBIC GLYCOLYSIS AUGMENTED%WIKIPATHWAYS_20260610%WP4628%HOMO SAPIENS Aerobic glycolysis augmented HEL-S-87p PFKM HEL-S-133P HEL-S-68p GPT HEL-S-30 ENO1 HEL-S-162eP PGAM2 HEL-S-49 SEROTONIN TRANSPORTER ACTIVITY%WIKIPATHWAYS_20260610%WP1455%HOMO SAPIENS Serotonin transporter activity STX1A MAOA IL1R1 TGFB1I1 ITGB3 TPH2 IL1B MACROPHAGE MARKERS%WIKIPATHWAYS_20260610%WP4146%HOMO SAPIENS Macrophage markers LYZ CD74 CD163 CD83 CD68 F3 CD14 HEPATITIS C AND HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260610%WP3646%HOMO SAPIENS Hepatitis C and hepatocellular carcinoma SOS1 IL6 CCND1 CD44 MYC FRZB HNF1A HEL-117 MAPK8 BIRC5 E2F2 NFKB1 TGFBR1 CXCL8 MAPK3 STAT3 PTPN11 MAPK14 BIRC3 CXCR1 JUN NOS2 IL6R LEF1 RRM2 MYOF GRB2 TGFB1 CDKN1A BRCA1 COL4A2 CASP9 CASP3 SMAD4 HIF1A JAK1 TNFSF6 PTGS2 VEGFA RAC1 VAV2 BCL2L1 TCA CYCLE AKA KREBS OR CITRIC ACID CYCLE %WIKIPATHWAYS_20260610%WP78%HOMO SAPIENS TCA cycle aka Krebs or citric acid cycle MDH2 SDHB SUCLG2 ACO2 SDHC SDHD SDHA SUCLA2 OGDH IDH3B SUCLG1 DLD CS FH TH17 CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260610%WP5130%HOMO SAPIENS Th17 cell differentiation pathway IRF4 IL22 HLA-DMA IL27 IL1B MAPK8 RXRA MAPK1 FOXP3 NFIL3 TBX21 IFNGR1 NR1D1 STAT1 IL23A STAT3 IKBKB MAPK14 MTOR RUNX1 GATA3 IL6R TYK2 IL2 ZAP70 LCK SOCS3 HIF1A PER1 IL-21 PLCG1 CRY1 NFATC1 CD3G PRKCQ CD3E IL6 PPP3CA RORA LAT TGFBR1 NFKB1 SMAD2 IL2RA JUN IL21R AHR IL4 NFKBIA TGFB1 IL23R IL17F IL27RA IL17A CD3D JAK1 IFNG RORC FOS RARA FBXL10 ENHANCEMENT OF MAP ERK SIGNALING IN DIFFUSE LARGE B CELL LYMPHOMA%WIKIPATHWAYS_20260610%WP4553%HOMO SAPIENS FBXL10 enhancement of MAP ERK signaling in diffuse large B cell lymphoma BCOR SUZ12 H3C15 H2AX H3C8 H3F3B MAPK1 H2AZ1 EED BCL6 MAPK3 H2AZ2 H2AB3 H2AB1 MACROH2A2 RNF2 H2AJ PCGF1 EZH2 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA%WIKIPATHWAYS_20260610%WP111%HOMO SAPIENS Electron transport chain OXPHOS system in mitochondria COX5A COX7A1 COX3 SDHC NDUFA9 SDHD NDUFA5 NDUFA13 NDUFA11 NDUFA12 ATP5G1 COX6A2 HEL-S-271 ATP5IF1 NDUFC2 NDUFC1 COX7A2L NDUFS6 NDUFS5 NDUFS4 NDUFS1 COX17 ND3 ND2 COX11 SLC25A14 ND5 SLC25A6 ND4 NDUFB9 ND6 NDUFB8 NDUFB7 NDUFB6 ATP8 NDUFB5 SCO1 NDUFB4 NDUFB3 ATP6 ATP5MC2 NDUFB2 UCP1 ATP5J NDUFB10 NDUFB1 ATP5MC3 COX7A2 ATP5H HEL-S-123m SDHB SLC25A27 UCP3 UCP2 NDUFV3 NDUFV2 ATP5MG ATP5MF ATP5ME NDUFA10 DMAC2L SURF1 NDUFA7 NDUFA6 ZNF183 ATP5PB NDUFA3 NDUFA2 ND4L ATP5F1D ATP5F1E NDUFAB1 ATP5PO COX7B COX6A1 COX2 COX7C COX1 CYB NDUFS8 UQCRC1 UQCRFS1 NDUFS3 COX8A ND1 COXFA4 UQCRC2 SDHA SLC25A5 UQCRB UQCR11 UQCR10 COX6B1 UQCRH UQCRQ SLC25A4 HEME BIOSYNTHESIS%WIKIPATHWAYS_20260610%WP561%HOMO SAPIENS Heme biosynthesis UROD UROS HMBS CPOX ALAS2 ALAS1 FECH LDL INFLUENCE ON CD14 AND TLR4%WIKIPATHWAYS_20260610%WP5272%HOMO SAPIENS LDL influence on CD14 and TLR4 CREB3L2 REL MAPK14 ATF4 IL6 IL10 RELB CREB1 RELA IL1B CD14 CREB3 TLR4 CREB5 NFKB1 MAPK12 NFKB2 MAPK13 MAPK11 CCL2 CREB3L3 CREB3L4 DOPAMINE METABOLISM%WIKIPATHWAYS_20260610%WP2436%HOMO SAPIENS Dopamine metabolism PPP2CA MAOA PRKACG TYR NQO1 DDC TH HEL-S-44 FACTORS AND PATHWAYS AFFECTING INSULIN LIKE GROWTH FACTOR IGF1 AKT SIGNALING%WIKIPATHWAYS_20260610%WP3850%HOMO SAPIENS Factors and pathways affecting insulin like growth factor IGF1 Akt signaling WASL TNLG5A MSTN HEL-S-28 DEPTOR ITGB1 GSK3B PRKAB1 MAPKAP1 IGF1 EIF2B2 AKT1S1 NFKB1 RICTOR PPARGC1A MLST8 SMAD2 MTOR TRIM63 IGFBP5 FBXO32 IRS1 ACVR2B PTEN RPTOR EIF4E MAP1LC3A IGF1R TNFRSF1A RPS6KB1 UREA CYCLE AND ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260610%WP4595%HOMO SAPIENS Urea cycle and associated pathways MDH2 SLC25A12 NOS2 GOT2 OTC ASL NAGS GPT SLC25A13 ASS1 GLUD1 ARG1 SLC25A15 FH HEL-S-32 HEL-S-281 GLS2 MOLYBDENUM COFACTOR MOCO BIOSYNTHESIS%WIKIPATHWAYS_20260610%WP4507%HOMO SAPIENS Molybdenum cofactor Moco biosynthesis SUOX MOCS1 GPHN AOX1 MTARC2 XDH MOCS2 BUTYRATE INDUCED HISTONE ACETYLATION%WIKIPATHWAYS_20260610%WP2366%HOMO SAPIENS Butyrate induced histone acetylation ACLY PURINERGIC SIGNALING%WIKIPATHWAYS_20260610%WP4900%HOMO SAPIENS Purinergic signaling GNAS PANX1 GNAO1 GNAI1 GNA11 P2RY8 GNAZ GNAT2 GNAT3 GNAT1 P2RY13 P2RY10 GNAI3 P2RY11 P2RY14 P2RX7 P2RX6 P2RX5 P2RX4 P2RX3 P2RY6 P2RX2 P2RY4 P2RX1 ADORA2A ADORA2B P2RY2 P2RY1 LPAR4 GLP 1 IN PANCREATIC ISLET CELLS%WIKIPATHWAYS_20260610%WP5447%HOMO SAPIENS GLP 1 in pancreatic islet cells SLC2A2 GCG IL6R IL6 GLP1R INS DOCOSAHEXAENOIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260610%WP5154%HOMO SAPIENS Docosahexaenoic acid oxylipin metabolism EPHX2 PTGS2 THYROID STIMULATING HORMONE TSH SIGNALING%WIKIPATHWAYS_20260610%WP2032%HOMO SAPIENS Thyroid stimulating hormone TSH signaling GNB1 PDPK1 PIK3CA RPS6KA1 RB1 CREB1 PLCB1 MAP2K1 GNAS PIK3R2 GNA13 PIK3R1 CCND3 MAPK1 MAPK3 GNAO1 RPS6 RAF1 STAT1 STAT3 GNAI1 RAP1A CCNE1 MAPK14 MTOR PDE4D ADCY3 CDK4 APEX1 CDK2 MAP2K3 RBL2 GNAI3 CDKN1B GNG2 RAP1GAP SRC CGA HRAS TSHB JAK1 KCNIP3 MAP2K6 SCRIB IGF1R TSHR MYL12B RPS6KB1 OSTEOCLAST SIGNALING%WIKIPATHWAYS_20260610%WP12%HOMO SAPIENS Osteoclast signaling IFNB1 TNFRSF11B CTSK TRPV5 ACP5 AIMP2 MAPK8 IFNAR1 opn TNFRSF11A ITGB3 ATP6V1G1 GPR68 TNFSF11 THYROXINE THYROID HORMONE PRODUCTION%WIKIPATHWAYS_20260610%WP1981%HOMO SAPIENS Thyroxine thyroid hormone production TRH PRKCA SLC5A5 DUOX1 CLCN5 TG HEL-S-5 PRKAA2 DUOX2 CREB1 MAP2K1 TPO MAP2K2 PRKAA1 MAPK1 NFKB1 MAPK3 RAF1 CGA TSHR RAP1A ARYL HYDROCARBON RECEPTOR RESPONSE TO MAIN MEDIATORS PAH AND TCDD%WIKIPATHWAYS_20260610%WP2586%HOMO SAPIENS Aryl hydrocarbon receptor response to main mediators PAH and TCDD CYP1A2 NQO1 CYP1A1 RB1 CYP1B1 GCLC PLAGL1 MYC KLF6 MAP2K1 NF1 LPL NFE2L2 NRAS MAPK1 NFKB1 NCOR2 FGF21 RAF1 EGFR TNF CD36 RET CDC37 EP300 CCL1 AHR CDK2 RELA AIP AHRR CDKN1A CDKN1B SRC HRAS PTGS2 VEGFA 15Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260610%WP4940%HOMO SAPIENS 15q11 2 copy number variation syndrome NIPA2 CYFIP1 FMR1 TUBGCP5 NIPA1 TUBGCP6 TUBGCP4 NCRNAS INVOLVED IN STAT3 SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260610%WP4337%HOMO SAPIENS ncRNAs involved in STAT3 signaling in hepatocellular carcinoma IL6ST SOX4 IL6R NFKB1 IL11 IL6 IL11RA JAK3 JAK1 STAT3 RELA EFFECT OF INTESTINAL MICROBIOME ON ANTICOAGULANT RESPONSE OF VITAMIN K ANTAGONISTS%WIKIPATHWAYS_20260610%WP5273%HOMO SAPIENS Effect of intestinal microbiome on anticoagulant response of vitamin K antagonists NPC1L1 SCARB1 NR1i1 NR1C1 NR1i2 CD36 NR1C2 CYP2C9 MAMMARY GLAND DEVELOPMENT PREGNANCY AND LACTATION STAGE 3 OF 4%WIKIPATHWAYS_20260610%WP2817%HOMO SAPIENS Mammary gland development pregnancy and lactation stage 3 of 4 NFIA ERBB4 NR3C1 ERBB3 CCND1 ERBB2 MYC CSN2 EIF4G1 PRLR CEBPB YY1 DLGAP4 TFPI2 USF2 NR3A2 USF1 CLDN6 TTC9 EGFR GJB2 NRG1 GAL NFIB ORAI1 PGR HDGFL2 TPM3 CHUK CEBPA ELF5 STAT5B PTPN1 TNFRSF11A PRL EIF4E BCL2L1 TNFSF11 SIGNAL TRANSDUCTION THROUGH IL1R%WIKIPATHWAYS_20260610%WP4496%HOMO SAPIENS Signal transduction through IL1R IFNB1 MYD88 IL6 ECSIT IL1B MAPK8 IL1RN NFKB1 MAP3K14 TNF IKBKB IRAK2 MAP3K7IP1 IRAK3 MAPK14 JUN CHUK MAP2K3 RELA NFKBIA TRAF6 TGFB1 IFNA1 MAP3K7 IL1R1 IL1A IRAK1 MAP2K6 MAP3K1 LACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260610%WP5303%HOMO SAPIENS Lacto series sphingolipid metabolism hCG_1998026 B3GNT5 B3GALT2 B3GALT1 FUT1 FUT3 GABA METABOLISM AKA GHB %WIKIPATHWAYS_20260610%WP4157%HOMO SAPIENS GABA metabolism aka GHB GAD1 HEL-S-166mP GAD2 ALDH5A1 PON3 ADHFE1 ABAT GLS GLS2 HEPATITIS B INFECTION%WIKIPATHWAYS_20260610%WP4666%HOMO SAPIENS Hepatitis B infection MAPK10 TGFBR2 HEL-S-93 CREB1 YWHAQ HEL-S-1 CXCL8 TNF TBK1 EP300 HSPG2 VDAC3 PIK3CD EGR2 IRF3 MAP2K3 DDX3X IFIH1 TRAF3 TYK2 TRAF6 IRF7 IFNAR1 JAK3 STAT4 SMAD4 MAP2K6 FADD MAP3K1 IFNB1 STAT2 IKBKE MAVS IL6 MYC RIGI MAP2K1 MAP2K2 NFATC4 PCNA TGFBR1 ATF2 RAF1 APAF1 DDB2 CREB3L3 CREB3L4 MAP3K7IP1 CREB3L2 SMAD2 ATF4 JUN TICAM2 IRAK4 TICAM1 TIRAP BCL2 IFNA5 IFNA4 TLR3 MAPK9 GRB2 IFNA7 IFNA6 CYCS IFNA1 IFNA2 CDKN1A IFNA8 MAPK12 CASP9 MAPK13 CASP8 MAPK11 CASP3 HRAS IRAK1 JAK1 CASP12 FOS MYD88 PIK3CA SOS1 IFNA13 IFNA14 IFNA16 IFNA17 MAPK8 IFNA10 MAPK1 PTK2B MAPK3 IFNA21 BAD ARAF STAT1 STAT3 IKBKB AKT3 MAPK14 IKBKG CHUK BAX SOS2 RELA CREB3 STAT5B CREB5 ATF6B CREBBP SRC MMP9 MAP2K4 PRKCB NFATC3 NFATC2 NFATC1 PRKCA DDB1 PIK3R3 PIK3R2 PIK3R1 BIRC5 TLR4 NRAS NFKB1 TGFB1 CASP10 MAP3K7 TNFSF6 PHOTODYNAMIC THERAPY INDUCED UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260610%WP3613%HOMO SAPIENS Photodynamic therapy induced unfolded protein response ATF4 BCL2L11 PPP1R15A EIF2A XBP1 EDEM1 BBC3 UBE2E1 ASNS NFE2L2 HEL-S-99n DNAJC3 SULT1E1 DDIT3 NARS1 DNAJB11 DNAJB9 ERP27 HEL-S-125m TRIB3 HEL-S-89n ERN1 ATF3 NRF2 ARE REGULATION%WIKIPATHWAYS_20260610%WP4357%HOMO SAPIENS NRF2 ARE regulation PIK3CA YES1 PRKCA HMOX1 NQO1 GCLM KEAP1 RBX1 AIMP2 GCLC MAF SLC7A11 GSK3B MAPK8 NFE2L2 CEBPB EPHB2 INSR SRC FYN PGAM5 EPITHELIAL TO MESENCHYMAL TRANSITION IN COLORECTAL CANCER%WIKIPATHWAYS_20260610%WP4239%HOMO SAPIENS Epithelial to mesenchymal transition in colorectal cancer JAG2 NOTCH1 TGFBR2 DLL3 DLL4 CTDSP1 CLDN6 RBBP4 TJP1 FMNL2 PIK3CD CDH2 MAP2K3 WNT3A TRAF6 EED SMAD4 MAP2K6 HEL-S-79 CLDN2 FOXQ1 EZH2 CDKL2 CLDN5 CLDN4 CLDN3 CLDN9 CLDN7 PKP2 PKP1 EIF5A2 ID1 MEF2D PALS1 NRP2 MAP2K1 CLDN22 CLDN20 MAP2K2 CLDN24 CLDN23 SHC1 PROX1 CLDN11 CLDN10 LATS2 FZD7 CLDN15 TGFBR1 CLDN14 MMP15 CLDN19 FZD8 STRAP CLDN18 RAF1 CLDN17 CLDN16 TMPRSS4 NUBPL CRB3 TWIST2 SMAD2 SPARC SUZ12 FOXC2 CLDN1 ZEB2 GRB2 SNAI1 SNAI2 LRP5 MAPK12 LRP6 MAPK13 MAPK11 HRAS FZD1 NOTCH3 NOTCH4 RBPJ PIK3CA SOS1 COL4A3 MAPK8 COL4A5 PAK1 MAPK1 MAPK3 AKT3 NR2C2 MAPK14 GDF15 SOS2 GIG8 TUSC3 JUP COL4A2 COL4A1 COL4A4 COL4A6 HIF1A MMP9 MAP2K4 VTN MMP2 GSK3B WNT2B FZD10 PIK3R3 PIK3R2 PKD1 WNT5B PIK3R1 WNT9B WNT9A WNT16 WNT8A TWIST1 WNT8B WNT3 WNT4 WNT10B WNT10A FZD3 FZD5 FZD4 WNT7B FZD9 WNT7A NOTCH2 TGFB1 FOXM1 WNT1 FZD2 VITAMIN A AND CAROTENOID METABOLISM%WIKIPATHWAYS_20260610%WP716%HOMO SAPIENS Vitamin A and carotenoid metabolism RARB RDH10 RDH8 RLBP1 RPE65 RDH12 ABCG8 ABCG5 RBP1 RDH5 LRAT LPL CYP2E1 RXRA NPC1L1 MAPK1 HEL-S-53e CD36 RETSAT ADH1A SDR16C5 CYP26B1 AWAT2 SCARB1 BCO1 CRABP2 HEL-S-4 CRABP1 DHRS3 SULT2B1 RXRB ALDH1A3 RXRG CYP26A1 RBP7 RBP4 RBP2 DGAT1 SULT1A1 ALDH1A2 NR1B3 RARA TYROSINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260610%WP4506%HOMO SAPIENS Tyrosine metabolism and related disorders GSTZ1 HPD PLEURAL MESOTHELIOMA%WIKIPATHWAYS_20260610%WP5087%HOMO SAPIENS Pleural mesothelioma MAPK10 PLCB4 CREB1 RPS6KA5 MAPKAPK2 ITGB1 VEGFB VEGFC ITGA4 ITGA2 YY1 SELE CSF2 SETD5 SETD2 CXCL1 CXCL5 KMT2C IL10 TRAF2 SETDB1 DDIT3 EED CCL5 CCL4 ATF3 CCL2 EZH2 MCL1 KIF23 RING1 RPS6KA1 IL6 MAP3K6 MAP3K5 CXCL12 PRKAB2 PRKAB1 EIF4G1 TGFA BTC SHC1 MMP3 LATS2 MMP14 MAP3K10 ATF2 MAP3K11 RPS6 NTRK2 HEL-S-31 PRKAG1 PRKAG2 PRKAG3 PDGFA MAP4K2 EPHA2 MINK1 SPARC IGF2 PRKAA2 INS MAPK9 FRAT2 MAPK7 RASSF2 SOX17 RASSF3 MAP4K3 CDH18 RASSF4 MAP3K2 RASSF6 BTRC CER1 CSNK2A3 CSNK2A2 ITGB3 DKK1 DKK2 ITGAV DKK4 SFRP1 NTF4 SFRP5 CSNK2B IDO1 STK38L KITLG PHC1 RASSF7 BAP1 CSF3 ITGA6 LIMD1 BMI1 PRSS23 TEAD2 FGF3 TEAD3 FGF4 TEAD4 CD44 FGF6 KREMEN1 FGF7 PIGF FGF9 VGLL4 WIF1 CTNNA1 IL1B CTNNA3 CTNNA2 RYK COL4A3 NOTUM COL4A5 MAD2L1 CTBP2 WWC1 CDH9 EFNA5 CDH8 EFNA4 CDH6 FGF20 HEL-S-104 CDH4 FGF22 HMGN1 FGF21 ROR1 EGFR ROR2 FGF17 TNIK EFNA1 MAD1L1 DVL3 DSC3 EFNA3 PORCN FGF14 BAG2 EFNA2 CDH24 MOB1A FGF19 LIN28B FGF18 OGT MCU FGF10 CHD8 MDK FLT4 WDR5 SOST SENP2 LATS1 CDH10 CDH12 CDH15 CDH16 CDH19 SLC3A2 CXXC4 CTHRC1 MOBKL1A IL34 ASXL1 COL4A2 CSNK1A1L COL4A1 COL4A4 COL4A6 ANGPT4 ANGPT2 PDGFD PDGFC GSK3B WNT2B FZD10 WNT5B ITGB4 FOXO1 LAMC2 WNT16 LAMC1 RB1CC1 MLST8 WNT3 WNT4 ULK1 WNT10B WNT10A FZD3 FZD5 WNT7B FZD9 WNT7A AREG LAMA5 LAMA1 LAMA4 LAMA3 FRAT1 CTBP1 PAK6 PAK4 LAMB3 LAMB2 LAMB1 VEGFD NF2 YAP1 DVL1 FZD2 CDK7 CDH17 ITGA1 TTI1 CSNK1A1 UHRF1 HEL-S-1 PRKAA1 CSF1 RBBP4 APC HMGB1 AGER PIK3CD FGF8 CDH2 MAP2K3 WNT3A CTGF AJUBA NTRK1 NGF EIF4B MAP2K6 FOSL1 MAP3K1 FGFR4 RPS6KB1 CSNK2A1 CCND1 MEF2D MYC MAP2K1 ULK2 MAP2K2 BBC3 HGF TSC2 CCND3 TSC1 FZD7 CCND2 AXIN1 NTF3 FZD8 SFRP4 RAF1 DVL2 ACTG2 CCNE1 EIF4EBP1 BARD1 JUN SUZ12 RHEB CDK4 SP1 CDK2 FGF13 BCL2 MDM2 GRB2 FGF12 ATM CYCS CDKN1A LRP5 PTEN BRCA1 RPTOR LRP6 NGFR BDNF HRAS CDH11 JAK1 FZD1 MAP4K1 AMOT NLRP3 HBEGF PIK3CA SOS1 DEPTOR MAPK8 PAK1 AKT1S1 MAPK1 PPARGC1A SLC7A5 MAPK3 FLT3 STAT1 CDKN2A RNF2 AKT3 MAPK14 WWTR1 MTOR TERT BAX KIT CSF1R FLT3LG LEF1 TCF7L2 TCF7L1 hCG_2014051 PDGFRA FLT1 RPS6KB2 ANGPT1 SRC FGF2 HIF1A MMP9 VEGFA IGF1R KDR DKFZp781B1423 MAP2K4 FGFR2 CIT RASSF1 EGF MMP2 MAP2K5 FGFR1 IGF1 INSR NFKB1 PRB1 PRB2 FGF23 CD47 FGFR3 ACTA2 TNNT1 LGALS9 ACTG1 PS1TP5BP1 TGFB1 BAK1 FOXM1 HCFC1 GABPA ACTA1 WNT1 MAX OVERVIEW OF NANOPARTICLE EFFECTS%WIKIPATHWAYS_20260610%WP3287%HOMO SAPIENS Overview of nanoparticle effects CRP HMOX1 BAX IL6 LAMA3 PIK3CD BCL2 CCND3 CXCL8 COL4A1 NFRKB PTGS2 TNF PTGS1 AKT3 SULFATION BIOTRANSFORMATION REACTION%WIKIPATHWAYS_20260610%WP692%HOMO SAPIENS Sulfation biotransformation reaction SULT1C4 SULT2B1 SULT1A1 SULT1E1 PAPSS2 SULT2A1 PAPSS1 HEL-75 SULT1C3 SULT1B1 SULT1C2 SULT6B1 SULT1A4 SULT1A2 GLYCOSYLATION AND RELATED CONGENITAL DEFECTS%WIKIPATHWAYS_20260610%WP4521%HOMO SAPIENS Glycosylation and related congenital defects ALG12 ALG1 ALG11 DPM1 DPM2 DPM3 GCS1 DPAGT1 B4GALT1 TUSC3 GMPPB MAGT1 MGAT2 ALG8 MPDU1 SRD5A3 ALG9 DOLK ALG6 ALG2 ALG14 ALG13 ALG3 DIFFERENTIATION OF WHITE AND BROWN ADIPOCYTE%WIKIPATHWAYS_20260610%WP2895%HOMO SAPIENS Differentiation of white and brown adipocyte DGIC CEBPG HSPB7 CIDEA SMAD9 EBF3 SLC7A10 CEBPA ZIC1 PRDM16 DKFZp781O1323 HOXC9 ZNF423 HOXC8 MPZL2 CEBPB BMP7 SMAD1 PPARGC1A LEP PPARGC1B BMP4 PPARG BMP2 TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260610%WP75%HOMO SAPIENS Toll like receptor signaling MAPK10 MYD88 IFNA13 IFNA14 IFNA16 IFNA17 IL1B MAPK8 IFNA10 CXCL9 MAPK1 CXCL8 MAPK3 IFNA21 STAT1 TNF IKBKB AKT3 TBK1 MAPK14 IKBKG CHUK IFNAR2 IRF3 MAP2K3 TRAF3 RELA TRAF6 CD14 IRF7 TLR7 IFNAR1 CCL5 CCL4 CCL3 RIPK1 MAP2K6 FADD MAP2K4 IFNB1 IKBKE MAP3K8 IL6 CXCL11 MAP2K1 MAP2K2 LBP TAB3 NFKBIB TLR4 opn NFKB1 CD40 CD80 MAP3K7IP1 JUN TICAM2 IRAK4 TICAM1 TIRAP TLR9 IL12B TLR8 IFNA5 IL12A TLR5 IFNA4 TLR3 MAPK9 IFNA7 NFKBIA IFNA6 IFNA1 IFNA2 IFNA8 MAP3K7 MAPK12 MAPK13 CASP8 MAPK11 TLR1 IRAK1 RAC1 LY96 FOS REGULATION OF TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260610%WP1449%HOMO SAPIENS Regulation of toll like receptor signaling MAPK10 RBCK1 SMAD6 CXCL9 CXCL8 TNF IRAK2 TBK1 IRAK3 IFNAR2 PIK3CD IRF3 MAP2K3 TRAF3 TRAF6 IRF7 TLR7 IFNAR1 SOCS1 CCL5 CCL4 CCL3 TNFAIP3 RIPK1 MAP2K6 FADD IFNB1 PTPN6 IKBKE MAP3K8 IL6 CXCL11 SQSTM1 MAP2K1 MAP2K2 MAP3K7IP1 JUN PLK1 TICAM2 BTK IRAK4 TICAM1 TIRAP TLR9 TLR8 IFNA5 TLR5 IFNA4 TLR3 MAPK9 NFKBIA IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 PIK3R5 SYK MAPK12 MAPK13 CASP8 MAPK11 TLR1 IRAK1 MBL2 RAC1 FOS MYD88 PIK3CA IFNA13 IFNA14 IFNA16 IFNA17 IL1B MAPK8 IFNA10 MAPK1 RNF41 MAPK3 IFNA21 STAT1 IKBKB AKT3 TMED7 MAPK14 IKBKG CHUK RELA CD14 MAP2K4 PIK3R3 LBP PIK3R2 TAB3 OTUD5 PIK3R1 FBXW5 TLR4 CD180 opn TRAFD1 NFKB1 SIGIRR NFKB2 CYLD MLST8 CUEDC2 TREM1 CD40 SFTPD CD80 PELI1 ZMYND11 RNF31 SFTPA2 PELI3 SARM1 IL12B IL12A MAP3K7 TIFA CISH LY96 NAD METABOLISM%WIKIPATHWAYS_20260610%WP3644%HOMO SAPIENS NAD metabolism NRK SIRT4 NMNAT3 SIRT6 SIRT7 NMNAT1 NADK SIRT5 NMNAT2 SIRT2 SIRT3 NAMPT NT5E SIRT1 4 HYDROXYTAMOXIFEN DEXAMETHASONE AND RETINOIC ACIDS REGULATION OF P27 EXPRESSION%WIKIPATHWAYS_20260610%WP3879%HOMO SAPIENS 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression EIF4EBP1 MTOR PIK3CA HEL164 MAP3K5 PIK3CD MAP2K3 MAP2K1 MAP2K2 PIK3R3 PRKAA1 PIK3R2 TSC2 PIK3R1 TSC1 MAPK1 MAPK3 MAP3K11 RAF1 EIF4E MAP2K6 ADIPOGENESIS%WIKIPATHWAYS_20260610%WP236%HOMO SAPIENS Adipogenesis NR3C1 CREB1 RETN KLF6 TNF PTGIS IL6ST GATA3 SCD IRS1 EGR2 DDIT3 SOCS3 SOCS1 TRIB3 IRS4 STAT2 RB1 IL6 MEF2D LPL PCK1 MEF2C SFRP4 CYP26B1 GADD45B GADD45A CYP26A1 FOXC2 RXRG SP1 AHR INS CNTFR MBNL1 CDKN1A NR1H3 FZD1 OSM LIF BMP1 MEF2B NCOA1 FRZB NAMPT HNF1A PRLR RXRA PPARGC1A NCOR2 NCOR1 STAT1 GH1 NR1C2 STAT3 HMGA1 WWTR1 LIPE CEBPA GDF10 RBL2 STAT5B HIF1A UCP1 RORA GATA4 IGF1 WNT5B FOXO1 CEBPB BMP3 CEBPD TWIST1 SLC2A4 LEP PPARG WNT10B LPIN1 PCK2 GATA2 BSCL2 LPIN2 LPIN3 CISD1 GTF3A ADFP CFD ZMPSTE24 NDN NR2F1 TGFB1 ID3 CELF1 KLF15 RBL1 LMNA PLIN1 ASIP SPOCK1 E2F4 KLF7 KLF5 BMP4 PNPLA3 NR1C1 MIXL1 BMP2 DVL1 WNT1 RARA OPIOID RECEPTOR PATHWAYS%WIKIPATHWAYS_20260610%WP5093%HOMO SAPIENS Opioid receptor pathways FAMILIAL PARTIAL LIPODYSTROPHY%WIKIPATHWAYS_20260610%WP5102%HOMO SAPIENS Familial partial lipodystrophy MGLL PIK3CA CIDEA KLF2 LPL HEL-S-104 PPARG GATA2 GATA3 LIPE CEBPA PRRX1 PNPLA2 INS LMNB2 ZMPSTE24 MAPK9 STAT5B LMNA PLIN1 KLF5 NR1C1 FNTA BANF1 ICMT CIDEC KLF9 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260610%WP47%HOMO SAPIENS Hedgehog signaling DHH SIN3A SUFU ADRBK1 PTCH2 IHH SAP18 GLI3 KIF7 SHH PTCH1 SMO AGE RAGE PATHWAY%WIKIPATHWAYS_20260610%WP2324%HOMO SAPIENS AGE RAGE pathway MYD88 CDC42 MSR1 ARHA MAPK8 MAPK1 MAPK3 EGFR STAT1 STAT3 IKBKB MAPK14 CHUK AGER IRS1 RELA STAT5B SRC HIF1A MMP9 PRKCB NCF1 PRKCA DDOST EZR HEL70 PRKCZ MMP2 MAP2K1 INHBB MMP7 HEL-S-44 SHC1 FOXO4 FOXO1 MMP14 INSR NFKB1 ATF2 RAF1 ALPL SMAD2 ROCK1 JUN NOS2 IRAK4 TIRAP SP1 INS MAPK9 NFKBIA CYCS CASP9 CASP8 CASP3 RAC1 ENDOCHONDRAL OSSIFICATION%WIKIPATHWAYS_20260610%WP474%HOMO SAPIENS Endochondral ossification PTH1R BMPR1A IHH PLAT CDKN1C ADAMTS4 ADAMTS5 MGP NKX3-2 FRZB SOX6 SOX5 CAB39 PTHLH CST5 KIF3A HMGCS1 STAT1 GH1 PTCH1 FGF18 GHR ACAN COL10A1 STAT5B SOX9 FGF2 RUNX2 MMP9 IGF1R VEGFA TIMP3 DDR2 FGFR1 IGF1 PTH CHST11 BMP6 opn RUNX3 MEF2C THRA ALPL ENPP1 COL2A1 FGFR3 SCIN GLI3 IGF2 TGFB1 CALM1 BMP7 SARS CORONAVIRUS AND INNATE IMMUNITY%WIKIPATHWAYS_20260610%WP4912%HOMO SAPIENS SARS coronavirus and innate immunity IFNB1 STAT2 IKBKE MAVS RIGI IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 IFNA21 STAT1 TBK1 IFNAR2 TICAM1 ACE2 IRF3 IFNA5 IFNA4 IFIH1 TRAF3 TLR3 IFNA7 TYK2 IFNA6 IFNA1 IFNA2 IFNA8 IFNAR1 IRF9 JAK1 MAP3K1 ROLE IN PROMOTING AND BLOCKING GONADAL DETERMINATION%WIKIPATHWAYS_20260610%WP4872%HOMO SAPIENS MAP3K1 role in promoting and blocking gonadal determination FGFR2 ROCK1 FRAT1 FGF9 GADD45G GSK3B ARHA FOXL2 SRY SOX9 MAPK1 AXIN1 MAPK11 WNT4 MAP3K1 MAMMALIAN DISORDER OF SEXUAL DEVELOPMENT%WIKIPATHWAYS_20260610%WP4842%HOMO SAPIENS Mammalian disorder of sexual development DHH FGFR2 PBX1 FGF9 GATA4 FST FOXL2 SOX9 SRY EMX2 RBFOX2 DMRT1 CBX2 AMH NR5A1 MAPK11 RSPO1 WT1 WNT4 SOX8 INSL3 AMHR2 MACROPHAGE STIMULATING PROTEIN MSP SIGNALING%WIKIPATHWAYS_20260610%WP5353%HOMO SAPIENS Macrophage stimulating protein MSP signaling CSF3 SP7 EGR1 RPS6KA5 ITGB1 IL1B MAPK8 SMAD6 MAPK1 CSF2 CXCL8 PPARGC1A MAPK3 TJP1 CXCL1 CXCL2 SLPI TNF MST1R CXCL5 KLK15 NR0B2 ACACA MAPK14 MTOR IL10 RPS6KA4 CDH2 RELA IBSP PDGFRA SMAD1 COL4A1 SOCS3 FLT1 SOCS1 SRC CCL2 MMP9 IGF1R VEGFA KDR RPS6KB1 PRKCB PLCG1 IFNB1 CLDN5 PDPK1 RPS6KA1 HEL-S-133P SMAD9 IL6 CRKL DKFZp781O1323 DUSP4 MAP2K1 GSK3B FGFR1 MAP2K2 PCNA SHC1 CPT1A PIK3R1 NFKB1 RPS6 RAF1 WNT10B SMAD2 SIX1 JUN ACTA2 HK2 PRKAA2 CLDN1 ZEB2 MAPK9 GRB2 TGFB1 SNAI2 PTEN HEL-S-102 FZD1 HEL113 BGLAP FOS MIRNA TARGETS IN ECM AND MEMBRANE RECEPTORS%WIKIPATHWAYS_20260610%WP2911%HOMO SAPIENS miRNA targets in ECM and membrane receptors SDC2 ITGA1 THBS1 LAMA4 THBS2 COL1A2 LAMB2 COL5A3 COL6A1 COL5A2 XB LAMC1 COL4A2 COL4A1 ITGB6 COL3A1 RIBOFLAVIN AND COQ DISORDERS%WIKIPATHWAYS_20260610%WP5037%HOMO SAPIENS Riboflavin and CoQ disorders COQ2 FLAD1 SLC52A2 SLC52A1 PDSS1 ETFA COQ8A COQ9 APTX COQ7 COQ6 ENVELOPE PROTEINS AND THEIR POTENTIAL ROLES IN EDMD PHYSIOPATHOLOGY%WIKIPATHWAYS_20260610%WP4535%HOMO SAPIENS Envelope proteins and their potential roles in EDMD physiopathology SOS1 SYNE2 HEL-S-15 MAP2K1 MAP2K2 ARHA NRAS MAPK1 MAPK3 TMEM43 SMAD2 HEL-S-61 WWTR1 ADCY3 SOS2 ADCY1 SYNE4 ADCY8 SYNE3 LBR GRB2 ADCY6 CTGF EMD TGFB1 SUN1 ADCY5 LEMD3 HEL-S-7a YY1AP1 ADCY9 PLEC SMAD4 HRAS BANF1 SYNE1 MITOCHONDRIAL BETA OXIDATION%WIKIPATHWAYS_20260610%WP5241%HOMO SAPIENS Mitochondrial beta oxidation HSD17B10 ACADSB ECHS1 ACADL EHHADH ACSL3 DECR1 GLUCOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260610%WP5280%HOMO SAPIENS Glucocorticoid biosynthesis AKR1C1 HSD11B1 HSD11B2 AKR1C2 SRD5A2 AKR1C4 CYP11B2 AKR1D1 CYP3A4 CYP21A2 TNF ALPHA SIGNALING%WIKIPATHWAYS_20260610%WP231%HOMO SAPIENS TNF alpha signaling SOS1 TXN NFKBIE MAPK8 MAPK1 TRADD MAPK3 BAD TRAF1 TNF IKBKB TBK1 IKBKG CHUK MADD BAX TRAF2 PIG59 MAP2K3 TANK CREBBP OTUD7B TNFAIP3 PYGL SMPD2 RIPK1 MAP2K6 PSMD2 FADD MAP3K1 FBXW11 BCL2L1 CYBA MAP2K4 KSR2 REL SKP1 PTPRCAP NSMAF DIABLO RFFL CSNK2A1 MAP3K8 PRKCZ MAP3K5 TAB3 NFKBIB RIPK3 KSR1 NRAS NFKB1 NFKB2 MAP3K14 APAF1 RAF1 TNFRSF1B MAP3K7IP1 BIRC2 BIRC3 PPP2CA CDC37 MAP4K2 JUN PLK1 MAPK9 NFKBIA GRB2 MAP3K7 BTRC CASP9 CASP8 CASP3 HRAS RAC1 TNFRSF1A COVID 19 ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260610%WP4891%HOMO SAPIENS COVID 19 adverse outcome pathway IL7 CSF3 IL2RA TMPRSS2 IL6 IL10 ACE2 IL2 IL1B CXCL8 CCL3 CCL2 TNF NETRIN UNC5B SIGNALING%WIKIPATHWAYS_20260610%WP4747%HOMO SAPIENS Netrin UNC5B signaling PIK3CA NTN1 PRKCA RLF NTN3 INPP5D PLEKHH1 ARHGEF12 AGAP2 UNC5B CIP2A MAP2K1 DCSTAMP COL1A1 MYF5 MAP2K2 VCAM1 ARHA ITGB4 MAPK1 SELE PTK2B MAPK3 RAF1 ALPL PPP2R1B TNF RGMA PTPN11 MAPK14 ROBO4 JUN IL10 CTGF PTPA YAP1 SRC CASP3 FYN IL1A CCL2 KDR RAC1 THIAMINE METABOLIC PATHWAYS%WIKIPATHWAYS_20260610%WP4297%HOMO SAPIENS Thiamine metabolic pathways PDHA1 DKFZp667O1614 SLC19A2 HEL107 OGDH BCKDK SLC19A3 PHOSPHOINOSITIDES METABOLISM%WIKIPATHWAYS_20260610%WP4971%HOMO SAPIENS Phosphoinositides metabolism PLCG1 PIP4K2A OCRL PIK3CA PLCB3 PIK3R4 PIP5K1C PLCB4 INPP5D PLCG2 PLCB1 PLCB2 PLCD4 MTMR1 MTMR10 MTMR2 MTMR3 MTMR12 MTMR11 MTMR8 MTMR9 MTMR4 STM7 MTMR6 MTM1 PIP4P2 PIP4P1 PIP5K1A PLCE1 PIP4K2B SBF1 SBF2 SACM1L PIKFYVE PLCH1 PLCH2 PLCD3 PIK3CD PTEN PIK3C2G PIK3C2B PATHWAYS OF NUCLEIC ACID METABOLISM AND INNATE IMMUNE SENSING%WIKIPATHWAYS_20260610%WP4705%HOMO SAPIENS Pathways of nucleic acid metabolism and innate immune sensing IFNB1 MAVS RNASEH2C RIGI RNASEL IRF3 RNASEH2B RNASEH2A IFIH1 TREX1 RNASET2 CGAS MITA OAS1 ADAR CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260610%WP197%HOMO SAPIENS Cholesterol biosynthesis pathway CYP51A1 SQLE HMGCS1 SC5D MSMO1 HMGCR MVD FDFT1 FDPS MVK PMVK DHCR7 EICOSANOID METABOLISM VIA CYTOCHROME P450 MONOOXYGENASES PATHWAY%WIKIPATHWAYS_20260610%WP4720%HOMO SAPIENS Eicosanoid metabolism via cytochrome P450 monooxygenases pathway EPHX2 CYP4F2 CYP4A22 CYP2C18 CYP4A11 PPARG NR1C1 CYP4F12 FOLLICLE STIMULATING HORMONE FSH SIGNALING%WIKIPATHWAYS_20260610%WP2035%HOMO SAPIENS Follicle stimulating hormone FSH signaling EIF4EBP1 MAPK14 MTOR PRKCA RHEB FSHR CREB1 TSC2 FOXO1 MAPK1 SGK1 RPS6KB2 MAPK3 FSHB SRC RPS6 H3-4 RAF1 CGA APPL1 RPS6KB1 UDP DERIVED SUGARS SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260610%WP5394%HOMO SAPIENS UDP derived sugars synthesis in fibroblasts GCK HK2 UXS1 HK3 UGDH GFPT1 PGM3 ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20260610%WP554%HOMO SAPIENS ACE inhibitor pathway ACE2 CMA1 CTSG REN TGFB1 AGTR1 AGTR2 CYP11B2 KNG1 BDKRB2 ATP6AP2 BDKRB1 NR3C2 MAS1 PTF1A RELATED REGULATORY PATHWAY%WIKIPATHWAYS_20260610%WP4147%HOMO SAPIENS PTF1A related regulatory pathway KAT2B HES1 PROX1 NKX6-1 RBPJ PTF1A NOTCH1 FGF10 PDX1 RBPJL INTERFERON SIGNALING IN TUBERCULOSIS%WIKIPATHWAYS_20260610%WP4197%HOMO SAPIENS Interferon signaling in tuberculosis STAT2 MX1 IRF-1 IFI35 IFIT1 PSMB8 IFIT3 IFNAR2 TYK2 PIAS1 OAS1 IFNAR1 IFITM1 IRF9 SOCS1 IFNGR1 IFNGR2 STAT1 JAK1 IFNG VITAMIN B12 DISORDERS%WIKIPATHWAYS_20260610%WP4271%HOMO SAPIENS Vitamin B12 disorders CBLIF MTR CUBN MTRR AMN MMAA TCN2 TCN1 MMACHC MMADHC CD320 VITAMIN D METABOLISM%WIKIPATHWAYS_20260610%WP1531%HOMO SAPIENS Vitamin D metabolism CYP27A1 PTH CYP2R1 RXRA GC NR1i1 RXRB CYP27B1 CYP24A1 DHCR7 NONALCOHOLIC FATTY LIVER DISEASE%WIKIPATHWAYS_20260610%WP4396%HOMO SAPIENS Nonalcoholic fatty liver disease COX5A COX7A1 COX3 VCAM1 NDUFA9 PRKAA1 NDUFA5 CXCL8 ERN1 TNF IL6R BCL2L11 IRS1 TRAF2 PIK3CD XBP1 DDIT3 SOCS3 CCL2 NDUFB10 ITCH IL6 SDHB MAP3K5 PRKAB2 NR1H4 PRKAB1 NDUFA10 BBC3 MLXIPL MAP3K11 GSK3A PRKAG1 PRKAG2 LEPR PRKAG3 ATF4 JUN CYB PRKAA2 INS EIF2S1 NDUFS8 UQCRC1 MAPK9 UQCRFS1 NDUFS3 COXFA4 UQCRC2 CYCS SDHA UQCRB UQCR11 UQCR10 UQCRH NR1H3 CYC1 CASP8 CASP3 UQCRQ RAC1 PIK3CA CDC42 IL1B SDHC SDHD MAPK8 RXRA COXFA4L2 NDUFC2-KCTD14 COX6B2 NDUFB11 ADIPOR1 COX7B2 COX4I2 MLX COX8C MLXIP UQCRHL IKBKB AKT3 NDUFA13 NDUFA11 NDUFA12 BAX COX6A2 NDUFC2 CEBPA NDUFC1 COX7A2L NDUFS6 NDUFS5 NDUFS4 RELA NDUFS1 NDUFB9 NDUFB8 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 COX7A2 NDUFV3 NDUFV2 GSK3B PIK3R3 PIK3R2 CYP2E1 PIK3R1 NDUFA7 NDUFA6 ZNF183 INSR NFKB1 NDUFA3 NDUFA2 LEP NDUFAB1 COX7B COX6A1 ADIPOR2 COX2 COX1 COX7C TGFB1 COX8A BAK1 COX6B1 NR1C1 IL1A TNFSF6 PKLR TNFRSF1A DISORDERS OF MITOCHONDRIAL HOMEOSTATIS DYNAMICS PROTEIN IMPORT AND QUALITY CONTROL%WIKIPATHWAYS_20260610%WP5504%HOMO SAPIENS Disorders of mitochondrial homeostatis dynamics protein import and quality control AIFM1 HSPD1 PARK2 OPA1 HTRA2 MICOS13 MIPEP UFD1L XPNPEP3 UBXN1 CLPB OPA3 GDAP1L1 MFN1 SACS MFN2 PMPCB PMPCA UBXN6 PAM16 ATAD3A OXA1L PPA2 CLPP LONP1 TMEM126A YME1L1 MICU1 VCP SPG7 TRAK1 MFF TIMM50 PITRM1 MSTO1 MARCHF5 DNAJC19 TIMM8A TIMMDC1 TXNRD2 AGK USP9X GFER COQ5 MCL1 COQ3 PINK1 NPLOC4 PLEK STAT2 SFXN4 RTN4IP1 PYCR2 TXN2 C1QBP ENDOMETRIAL CANCER%WIKIPATHWAYS_20260610%WP4155%HOMO SAPIENS Endometrial cancer PIK3CA SOS1 AXIN2 HEL-S-28 CTNNA1 CTNNA3 CTNNA2 MAPK1 MAPK3 EGFR BAD APC ARAF AKT3 BAX SOS2 PIK3CD LEF1 TCF7L2 TCF7L1 FGF2 FGFR2 PDPK1 APC2 CCND1 ERBB2 EGF MYC MAP2K1 GSK3B FGFR1 MAP2K2 PIK3R3 PIK3R2 PIK3R1 NRAS AXIN1 FOXO3A RAF1 DDB2 FGFR3 POLK GADD45B GADD45A GADD45G GRB2 BAK1 CDKN1A PTEN CASP9 HRAS FOS FLT3 P GLN640SERFSTER8 SIGNALING%WIKIPATHWAYS_20260610%WP5431%HOMO SAPIENS FLT3 p Gln640SerfsTer8 signaling CCR5 FLT3 STAT3 CCR6 TCA CYCLE AND DEFICIENCY OF PYRUVATE DEHYDROGENASE COMPLEX PDHC %WIKIPATHWAYS_20260610%WP2453%HOMO SAPIENS TCA cycle and deficiency of pyruvate dehydrogenase complex PDHc PDHA1 ACLY PC HEL60 HEL-S-26 DLAT SUCLG2 SDHA OGDH PCK1 DLD CS FH HEL-S-32 VITAMIN D RECEPTOR PATHWAY%WIKIPATHWAYS_20260610%WP2877%HOMO SAPIENS Vitamin D receptor pathway TNFRSF11B CLMN TRPV5 CREG2 SPRR1B CDKN2D LRRC25 S100G KRTAP10-2 SALL4 KRTAP10-4 CDX2 KRTAP10-7 MX2 KRTAP10-9 ADAMTS5 CBS KRT13 G0S2 MYO9B ATP2B1 PTHLH DEFB132 KRT16 CD9 CTLA4 THBD JUNB BCL6 TNFAIP3 CLDN2 NR1i1 CCND1 ID1 DUSP10 MYC CCNE1 HLA-DQA2 HLA-DQA1 GADD45A CYP7A1 CDK2 HLA-DRB1 CDKN1A LRP5 CDKN1B EPHB4 SFRP1 S100A9 DNER IRF4 KLF4 ABCB1 HNF1A S100A6 CYP2C9 IRF8 RXRA CYP2B6 HSD17B2 EFNA5 MED9 SULT2A1 ITGAM CDKN2B CDKN2A NR1C2 CLEC16A CEBPA ADRB2 STEAP4 CD14 TRAK1 ALOX5 HIF1A SULT1C2 TIMP3 NFATC2 PRKCQ CYP1A1 LPGAT1 CCNC GXYLT2 TNLG2B SLC8A1 CYP3A4 STS KRT71 CDKN2C SLC34A2 LCE1F LCE1D LCE2B KL CDC34 NINJ1 PTH S100A4 BMP6 S100A8 FOXO1 COL13A1 opn CDKAL1 KLK6 ADGRE5 CRACR2A CYP27B1 CRACR2B SLC2A4 DND1 CYP24A1 BTLA TREM1 KRTAP4-1 CD40 SLC37A2 KRTAP12-2 KRTAP8-1 FGF23 TRPV6 CYP2S1 PNOC TPM1 ID4 CST6 ALPI CLPTM1L IL1RL1 MXD1 IGFBP5 ALPG ZNF257 CD200 ORM1 HILPDA IL25 ADRA1B ORM2 IL12A CASP14 LGALS9 CASP5 DACT2 TGFB1 SOSTDC1 KRTAP5-1 S100A2 CA9 IGFBP1 ABCD1 CAMP KRTAP5-4 KRT34 CEACAM1 KRT38 DEFB4B PTGER4 KNG1 COLEC11 SATB1 BDKRB1 HEL57 SEMA3B ASAP2 BGLAP TNFSF11 CST1 SELENIUM METABOLISM AND SELENOPROTEINS%WIKIPATHWAYS_20260610%WP28%HOMO SAPIENS Selenium metabolism and selenoproteins CTH RPL30 SELENOF NFE2L2 SELENOK SELENOI SELENOH NFKB1 SEPHS1 SEPHS2 PSTK EEFSEC FABP1 GPX2 GPX1 CREM POU2F1 GPX3 GPX6 DIO1 TRNAU1AP SELENOO SEPSECS JUN SELENON SARS1 SELENOM SARS2 SELENOP SELENOW SP1 SELENOV SELENOT MSRB1 SELS RELA SP3 HEL-S-134P GPX4 TXNRD2 FOS MAMMARY GLAND DEVELOPMENT EMBRYONIC DEVELOPMENT STAGE 1 OF 4%WIKIPATHWAYS_20260610%WP2813%HOMO SAPIENS Mammary gland development embryonic development stage 1 of 4 CLDN4 ITGA6 TERT ERBB4 CCND1 MYC ZEB2 ITGB1 NRG3 TGFB1 SFRP1 ALPL TNF 16P11 2 DISTAL DELETION SYNDROME%WIKIPATHWAYS_20260610%WP4950%HOMO SAPIENS 16p11 2 distal deletion syndrome NFATC2 CD81 LAT IFITM1 INSR SH2B1 TRAF1 CD82 RABEP2 CD19 TRAF2 PRMT1 ATP2A1 IL4 GRB2 PLN SLN NFATC2IP RAB5A RAB4A CR2 HEL-S-62p TUFM ATXN2L SPNS1 SDCCAG8 MPL KDR VAV2 CCL18 SIGNALING%WIKIPATHWAYS_20260610%WP5097%HOMO SAPIENS CCL18 signaling CCR8 PTK2B MMP2 AK4 CDH2 ZEB2 PRE IMPLANTATION EMBRYO%WIKIPATHWAYS_20260610%WP3527%HOMO SAPIENS Pre implantation embryo IRF4 EGR1 CDX2 TEAD4 ELAVL1 KLF4 SOX8 MACROH2A2 HMGA1 TFAP2B GATA3 BATF3 TCF7L1 DDIT3 NANOGNB AQP9 AQP3 DNMT3L KHSRP FOSB FOXQ1 SIX3 MYBL1 SOX11 ZAR1 ARGFX DPPA3 ZFP42 PADI6 BARX2 ZFP36L2 LEUTX NKX2-1 ZFP36 MTA3 SOX2 IRX5 TPRX1 HNRNPAB TBX3 MOS DPRX ZSCAN4 DLX2 GATA2 MXD1 SMARCA4 E2F5 PBX1 ESRRA ATP1A1 FOXD1 POU5F1 NR3C2 SARS COV 2 REPLICATION ORGANELLE FORMATION%WIKIPATHWAYS_20260610%WP5156%HOMO SAPIENS SARS CoV 2 replication organelle formation PIK3R4 COVID 19 AND ENDOTHELIAL CELL SENESCENCE%WIKIPATHWAYS_20260610%WP5256%HOMO SAPIENS COVID 19 and endothelial cell senescence TLR4 IL17A IL17RC IL17RA MITOPHAGY%WIKIPATHWAYS_20260610%WP5636%HOMO SAPIENS Mitophagy MAPK10 RAB7A BCL2L13 PARK2 SMURF1 OPA1 MAPK8 BNIP3 TBK1 MFN1 MFN2 PHB2 TRAF2 VCP MARCHF5 SRC HIF1A PGAM5 BCL2L1 PINK1 TOMM70 CSNK2A1 SQSTM1 ATG9A CITED2 TOMM20 FUNDC1 ARIH1 USP30 FOXO3A ATG9B TFEB MUL1 ULK1 RAB7B OPTN USP15 RAB5B NLRX1 RAB5C TOMM40 BECN2 AMBRA1 ATF4 RHOT2 JUN RHOT1 SAMM50 TBC1D17 TBC1D15 FIS1 MTX1 SP1 AMFR HUWE1 CCZ1 EIF2S1 MAPK9 NBR1 TOMM7 RAB5A BNIP3L CSNK2A3 CSNK2A2 CALCOCO2 MAP1LC3A SIAH1 SENESCENCE AND AUTOPHAGY IN CANCER%WIKIPATHWAYS_20260610%WP615%HOMO SAPIENS Senescence and autophagy in cancer IRF-1 BMI1 SERPINB2 PLAT CD44 IL24 IL1B DKFZp762B153 ATG14 AKT1S1 MAPK1 CXCL8 CXCL1 KMT2A CDKN2A IL6ST HMGA1 MAPK14 MTOR IL6R MAP2K3 IRF7 COL10A1 IL3 SRC SMAD4 CCL3 IGF1R INHBA CXCL14 VTN IFNB1 ATG3 THBS1 RB1 ATG10 IL6 ATG12 SQSTM1 DKFZp686F0183 MAP2K1 ATG16L1 GSK3B COL1A1 PCNA IGF1 CEBPB CDC25B MMP14 RB1CC1 GABARAPL2 MLST8 GABARAPL1 TNLG1B RAF1 ULK1 COL3A1 AMBRA1 JUN GABARAP IGFBP5 SPARC RNASEL INS BCL2 MDM2 ING1 TGFB1 LAMP2 SLC39A2 CDKN1A SLC39A1 CDKN1B SLC39A3 PTEN SH3GLB1 IFI16 CREG1 IGFBP7 UVRAG RSL1D1 HRAS IL1A BMP2 MAP1LC3A IFNG MAP1LC3C TESSADORI BICKNELL VAN HAAFTEN SYNDROME 3 OVERVIEW PATHWAY%WIKIPATHWAYS_20260610%WP5575%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome 3 overview pathway TBP H4C9 MED23 TAF13 TAF8 MED27 22Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260610%WP4657%HOMO SAPIENS 22q11 2 copy number variation syndrome DRD2 HES1 EMC10 POLR2A FGF8 H4C9 CLDN5 CLDN3 CRKL GLUD1 CDC45 RAF1 CYP26B1 CLTCL1 PLK1 SREBF2 CYP26A1 FOXC2 CLDN1 BCL2 GSC2 HDAC3 HIRA HIRIP3 TSKS ZDHHC8 RCC1 PITX2 C22orf39 THAP7 ASF1A RTL10 MED15 NPRL2 TRMT2A ESS2 CDC42 NKX2-5 PRODH HEL25 KLHL22 GP5 GP9 PARK2 LRRC74B SEPT8 MRPL40 DGCR6L DGCR8 TNPO1 SCARF2 DGCR2 GP1BB PAX3 C16orf35 GP1BA NCOR1 EGFR SEPT5 SLC7A4 GBX2 CYP26C1 GNB1L UFD1L DEPDC5 CCDC188 FOXC1 hCG_1641087 ARVCF DROSHA FGF10 TBX1 RANBP1 SERPIND1 ZNF74 HAND2 RAN CDH15 HEL-S-80p SHOC2 TXNRD2 FOXA2 FGFR2 RBX1 FGFR1 RTN4R SNAP29 SLC2A4 VWF ACTA2 RTN4 SHH RELN PAK4 P2RX6 ALDH1A2 SLC25A1 RORC EIF5A REGULATION IN RESPONSE TO INHIBITION OF THE NUCLEAR EXPORT SYSTEM%WIKIPATHWAYS_20260610%WP3302%HOMO SAPIENS eIF5A regulation in response to inhibition of the nuclear export system IGF2BP1 EIF5A XPO4 MTHFR DEFICIENCY%WIKIPATHWAYS_20260610%WP4288%HOMO SAPIENS MTHFR deficiency PEMT EHMT1 MARS1 CHKA HEL-S-61p CHDH CHPT1 CYCS ASMT ALDH7A1 GRIN1 CASP9 CASP3 DNMT3B CARDIAC PROGENITOR DIFFERENTIATION%WIKIPATHWAYS_20260610%WP2406%HOMO SAPIENS Cardiac progenitor differentiation BMP1 NOTCH1 SIRPA ZFP42 NODAL NKX2-5 MYL2 SOX2 GSK3B GATA4 NOG IGF1 CXCR4 MEF2C LIN28A TNNI3 ROR2 NRG1 MAPK14 LIN28B KIT MESP2 IGF2 MYLK3 MYH6 INS WNT3A TGFB1 MESP1 SOX17 THY1 TBXT SOX1 TBX20 SCN5A PDGFRA IRX4 TBX5 ISL1 DKK1 BMP4 FGF2 MIXL1 POU5F1 INHBA FOXA2 KDR NCAM1 LNCRNA MEDIATED MECHANISMS OF THERAPEUTIC RESISTANCE%WIKIPATHWAYS_20260610%WP3672%HOMO SAPIENS lncRNA mediated mechanisms of therapeutic resistance CDKN1A ABCB1 HIF1A BCL2L1 COVID 19 STRUCTURAL COVERAGE MAP%WIKIPATHWAYS_20260610%WP5145%HOMO SAPIENS COVID 19 structural coverage map UBB UBC TOMM70 MACROD1 HEL97 MACROD2 CMTR1 PAIP1 ACE2 PALS1 UPF2 SLC6A19 NRP1 AQR IGHMBP2 ISG15 MACROH2A2 PARP14 GDAP2 MAP3K7IP1 NLRP12 MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20260610%WP289%HOMO SAPIENS Myometrial relaxation and contraction pathways CAMK2A MYL4 PLCB3 HEL-S-93 PRKAR1B LPAR1 HEL2 PRKAR1A MYL2 CREB1 GNAS YWHAQ HEL-S-1 YWHAG CAMK2D DKFZp686L0365 GNGT1 PDE4B PDE4D PRKD1 CACNB3 GNG3 GNG5 GNG4 GNG7 GNG8 ATF3 GNG12 GNG11 GNG13 DGKZ GNB2 GNB1 GNB5 ATF1 IL6 ATF2 CALCA PRKCE ATF4 JUN SFN SP1 HEL-S-21 CALM1 FOS RGS16 IL1B RYR1 RYR2 RYR3 GNB4 MYLK2 GJA1 ADCY3 ADCY1 ADCY8 CREB3 ADCY6 ADCY5 ACKR3 ADCY9 ATF6B RAMP1 GNG2 PRKCB PLCG1 PRKCH PRKCA PRKCQ PRKCZ OXTR CRCP SLC8A1 RXFP2 PLCG2 RGS4 RGS5 CRH RGS2 RGS1 RGS6 IGFBP4 MAFF ATF5 ETS2 HEL-S-14 ITPR2 CNN2 GRK5 GRK4 NFKB1 CALD1 IGFBP6 PKIB PKIA RLN1 PKIG ADM OXT RGS18 RGS17 RAMP2 RAMP3 RGS20 CAMK2G ACTA2 CORIN IGFBP5 GUCA2B GUCA2A RGS10 RGS11 ACKR5 ACTG1 GNB3 PS1TP5BP1 GABPB1 IGFBP1 IGFBP2 GABPA ACTA1 ATP2A2 RGS14 LEUKOCYTE INTRINSIC HIPPO PATHWAY FUNCTIONS%WIKIPATHWAYS_20260610%WP4542%HOMO SAPIENS Leukocyte intrinsic Hippo pathway functions TEAD2 TEAD3 TEAD4 YWHAQ ARHA LPL FOXO4 CCR7 FOXO1 LATS2 FOXP3 FOXO3A RAP1A MAPK14 MOB1A WWTR1 CD19 FOXO6 LATS1 FYB1 KNSTRN RAB13 FERMT3 YAP1 RAC1 STK38L COMPLEMENT ACTIVATION%WIKIPATHWAYS_20260610%WP545%HOMO SAPIENS Complement activation C1QB CFD C4A C1S CFP C8A C6 C1QA C8G HEL-S-62p C7 C9 MASP2 MASP1 CFB CD55 C1QC C4B_2 COMPLEMENT SYSTEM IN NEURONAL DEVELOPMENT AND PLASTICITY%WIKIPATHWAYS_20260610%WP5090%HOMO SAPIENS Complement system in neuronal development and plasticity C4BPA C4BPB CLU ITGAX MFGE8 C3AR1 DLGAP5 CR1 ATP11C ATP11A PLSCR1 PLSCR3 PLSCR4 CD46 LLGL2 CRB2 MERTK CX3CL1 COLEC12 CRB1 AXL COLEC10 CFH C1QA C5AR2 CFI C5AR1 HTRA2 PARD6G ATP10A ITGAM PARD3 PARD6A CD59 DEDD MARK1 ATP8B3 ATP8B2 MBP BAX PARD6B CR2 HEL-S-62p VTN PRKCI DIABLO PRKCZ ATP8B1 PALS1 C4A APAF1 C4B_2 TYRO3 C1QB CAP1 CX3CR1 CFD C1S TGFB1 CASP10 CFP BAK1 CYCS C8A C6 C8G C7 C9 MASP2 ITGB3 CASP9 MASP1 CASP8 CFB CASP3 ITGAV CD55 COLEC11 C1QC FCN1 MBL2 TNFSF6 FCN2 SCRIB IFNG PATJ SERPING1 FCN3 PROS1 ACQUIRED PARTIAL LIPODYSTROPHY BARRAQUER SIMONS SYNDROME%WIKIPATHWAYS_20260610%WP5104%HOMO SAPIENS Acquired partial lipodystrophy Barraquer Simons syndrome LMNA HEL-S-62p CFB CFD FNTA LMNB2 ICMT RCE1 POST COVID NEUROINFLAMMATION%WIKIPATHWAYS_20260610%WP5485%HOMO SAPIENS Post COVID neuroinflammation CCL11 TMPRSS2 IL6 IL10 HMGB1 FURIN ACE2 TLR8 IL12A TLR3 IL2 IL4 IL1B IFNA2 TLR7 TLR4 GFAP MAPK1 CXCL8 IL18 IL1A IFNG TNF 7Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260610%WP4932%HOMO SAPIENS 7q11 23 copy number variation syndrome CDKN1C OGDH BRD4 MAPK3 USF1 FBN1 UBE2L6 CHTF18 ACACB ABHD11 ACACA HMGA1 BCL7B NUP62 ATP5G1 BUD23 GTF2I HEL-S-271 VPS9D1 UBE2E3 VPS37C VPS37D ATPAF2 VPS37A VPS37B BAZ1B HEL-S-162eP LAT2 EIF2A CLIP2 METTL27 FKBP6 UBE2E1 VPS28 ATPAF1 TRIM50 UBIAD1 HDAC2 DDX21 FBLN2 FBLN5 LIMK1 MVB12A EIF4H ATP8 CLASP1 CLASP2 SMARCA5 TMEM270 ATP6 DEK ATP5MC2 TBL2 MYO1C CLDN5 MYBBP1A RFC2 CLDN4 HSPA2 GTF2IRD1 CLDN3 ATP5MC3 RB1 HEL-S-123m SQSTM1 MYC HEL-S-15 HOXC8 H2AX PCNA MLXIPL ATP5PB ATP5F1D ULK1 ATP5F1E NRG1 SNAP25 ATP5PO FZD9 TSG101 ATF4 BTK GRIP1 CLDN1 GRB2 VAMP2 STX1A HDAC3 CLTC DLD PRKG1 PKLR GPCRS CLASS C METABOTROPIC GLUTAMATE PHEROMONE%WIKIPATHWAYS_20260610%WP501%HOMO SAPIENS GPCRs class C metabotropic glutamate pheromone GRM3 GRM2 GABBR2 GABBR1 CASR GPRC5A GRM6 GRM8 GPRC5D GPRC5C NIPBL ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260610%WP5119%HOMO SAPIENS NIPBL role in DNA damage Cornelia de Lange syndrome ATR RNF168 RNF8 CBX3 MDC1 H2AX NIPBL ATM FARNESOID X RECEPTOR PATHWAY%WIKIPATHWAYS_20260610%WP2879%HOMO SAPIENS Farnesoid X receptor pathway UGT2B4 FGF19 ABCB4 CYP3A4 BAAT CYP7A1 CYP8B1 NR1H4 SLCO2B1 ABCB11 IP6K3 SLC27A5 RXRA PPARGC1A SULT2A1 FKBP5 NR0B2 SELENIUM MICRONUTRIENT NETWORK%WIKIPATHWAYS_20260610%WP15%HOMO SAPIENS Selenium micronutrient network PLAT HEL-S-2a TXN CBS IL1B SELENOF SELENOK SELENOI SELENOH SEPHS2 GPX2 GPX1 MPO TNF GPX3 GPX6 DIO1 CRP SELENOO FLAD1 SCARB1 SELENON ALOX15B SELENOM SELENOP APOB SELENOW SELENOV LDLR SELENOT MSRB1 SELS RELA ALOX5 HEL-75 TXNRD2 ALOX5AP CCL2 CTH MTR IL6 SERPINA3 HEL-S-44 HEL-S-97n KYNU FGA HEL-S-302 KMO F7 INSR NFKB1 SAA4 NFKB2 PLG PRDX3 PRDX5 HEL-S-78p ALB SAA1 SAA2 HBB XDH HBA2 ABCA1 INS GPX4 F2 IFNG PTGS2 PTGS1 LIVER X RECEPTOR PATHWAY%WIKIPATHWAYS_20260610%WP2874%HOMO SAPIENS Liver X receptor pathway RXRA CYP2B6 SCD FASN NR1H3 CYP3A4 ABCG8 CYP7A1 ABCG5 VITAMINS A AND D ACTION MECHANISMS%WIKIPATHWAYS_20260610%WP4342%HOMO SAPIENS Vitamins A and D action mechanisms RXRA NR1i1 RARA EVOLOCUMAB MECHANISM TO REDUCE LDL CHOLESTEROL%WIKIPATHWAYS_20260610%WP3408%HOMO SAPIENS Evolocumab mechanism to reduce LDL cholesterol LDLR PCSK9 IL18 SIGNALING%WIKIPATHWAYS_20260610%WP4754%HOMO SAPIENS IL18 signaling PRKCB GRIN2B MYD88 NCF1 IL18RAP NCF2 IRF-1 PRKCA ELAVL1 CSN2 GSK3B NFATC4 PRKAA1 PIK3R1 CEBPB MAPK1 NFKB1 MAPK3 GATA1 TNF IKBKB SLC12A3 ACACB IMP3 CHUK BAX TICAM2 SP1 IL37 RELA MAPK9 NFKBIA TRAF6 CYCS MAP3K7 LCK PTEN HEL-S-102 IL18 CASP8 CASP3 IL18R1 IRAK1 TNFSF6 TNFRSF1A RPS6KB1 CARDIAC HYPERTROPHIC RESPONSE%WIKIPATHWAYS_20260610%WP2795%HOMO SAPIENS Cardiac hypertrophic response HDAC5 MAP2K4 CDK7 FGFR2 NFATC2 IKBKE PDPK1 PRKCA PPP3CA EGF MAP2K5 MAP2K1 GSK3B MAP2K2 MAPK8 IGF1 MAPK1 NFKB1 TGFBR1 CAMK2D MAPK3 MAP3K14 RAF1 NRG1 TNF IKBKB GUCA1A MAPK14 IKBKG MTOR CHUK PRKD1 MAP2K3 MAPK7 TGFB1 CALM1 MAP3K7 CDK9 NPPA PRKG1 FGF2 HDAC7 MAP2K6 MAP4K1 MAP3K1 RAC1 PLA2G2A TNFRSF1A GLYCEROPHOSPHOLIPID BIOSYNTHETIC PATHWAY%WIKIPATHWAYS_20260610%WP2533%HOMO SAPIENS Glycerophospholipid biosynthetic pathway GPAM PIK3CA CDIPT LPIN1 MOGAT3 PIP5K1A PGS1 PTDSS1 GNPAT GPAT4 HMFN0839 PTPMT1 GPD1 PEMT GPAT2 LPIN2 CEPT1 CHKB PCYT2 PIK3CD IPMK CRLS1 PI4K2A CDS2 CHPT1 PLA2G2A DNA MISMATCH REPAIR%WIKIPATHWAYS_20260610%WP531%HOMO SAPIENS DNA mismatch repair LIG1 RFC2 POLD2 POLE RFC3 RFC4 PCNA PMS2 POLE4 MSH6 MSH2 RPA1 RFC1 POLE2 RPA3 POLE3 POLD3 POLD4 PHOSPHATIDYL INOSITOL PHOSPHATE PATHWAY%WIKIPATHWAYS_20260610%WP5411%HOMO SAPIENS Phosphatidyl inositol phosphate pathway PLCG1 PIP4K2A OCRL PIK3CA PLCB3 PIP5K1C PLCB4 INPP5D PLCG2 PLCB1 PLCB2 PLCD4 MTMR1 MTMR2 MTMR8 STM7 MTMR6 MTM1 PIP4P2 PIP4P1 PIP5K1A PLCE1 PIP4K2B SACM1L PIKFYVE PLCD3 PIK3CD IPMK PI4K2A PI4K2B INPP5E TPTE2 FIG4 INPP4A PTEN PI4KB PIK3C2G PIK3C2B INPP4B LINOLEIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260610%WP5137%HOMO SAPIENS Linoleic acid oxylipin metabolism ALOX15 EPHX2 ALOX5 RESOLVIN E1 AND RESOLVIN D1 SIGNALING DECREASE INFLAMMATION%WIKIPATHWAYS_20260610%WP5191%HOMO SAPIENS Resolvin E1 and resolvin D1 signaling decrease inflammation MTOR PIK3CA EPHB2 GRK1 FPR2 CMKLR1 PIK3CD LTB4R DEGRADATION PATHWAY OF SPHINGOLIPIDS INCLUDING DISEASES%WIKIPATHWAYS_20260610%WP4153%HOMO SAPIENS Degradation pathway of sphingolipids including diseases NPC2 NEU4 GLA SCARB2 HEL-S-111 HEXA NEU2 NEU3 GLB1 LIPA GM2A PSAP NPC1 NEU1 SOMATIC SEX DETERMINATION%WIKIPATHWAYS_20260610%WP4814%HOMO SAPIENS Somatic sex determination DHH FGF9 GATA4 FOXL2 SRY SOX9 DMRT1 AMH NR5A1 RSPO1 WT1 WNT4 SOX8 NUCLEOTIDE EXCISION REPAIR IN XERODERMA PIGMENTOSUM %WIKIPATHWAYS_20260610%WP5114%HOMO SAPIENS Nucleotide excision repair in xeroderma pigmentosum SLX4 GTF2H2C_2 H2AC6 LIG1 CDK7 RFC2 SLX4IP GTF2H2 CHD1L POLE GTF2H3 UVSSA GTF2H4 RAD18 GTF2H5 RFC3 RBX1 RFC4 CUL4A DDB1 ERCC1 ERCC2 MNAT1 PCNA HMGN1 RPA1 XAB2 RFC1 RPA3 DDB2 POLD3 POLD4 POLK POLD2 CUL4B XPA GPS1 H4C9 H3F3B POLE4 BRCA1 HIST1H4L POLE2 POLE3 CCNH CETN2 XPC TESSADORI BICKNELL VAN HAAFTEN SYNDROME VARIANTS NUCLEOSOME ASSEMBLY%WIKIPATHWAYS_20260610%WP5573%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome variants nucleosome assembly H4C9 H2BC12 HIRA HIST1H4L CHAF1B CHAF1A RBBP4 SMIM40 UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260610%WP4925%HOMO SAPIENS Unfolded protein response CASP2 ATF4 PMAIP1 MBTPS2 BCL2L11 RTCB TNFRSF10B TXNIP EIF2S1 BCL2 PPP1R15A IL1B XBP1 BBC3 NFE2L2 DDIT3 HEL-S-89n ERN1 MBTPS1 INTRACELLULAR TRAFFICKING PROTEINS INVOLVED IN CMT NEUROPATHY%WIKIPATHWAYS_20260610%WP4856%HOMO SAPIENS Intracellular trafficking proteins involved in CMT neuropathy RAB11A MFN2 SBF2 RAB7A NEFL RAB3B EGR2 LRSAM1 RAB4B HSPB8 LITAF RAB11B FGD4 RAB4A FIG4 SH3TC2 RAB25 MTMR2 MPZ HEL-S-102 PMP22 KIF1B RABAC1 MESODERMAL COMMITMENT PATHWAY%WIKIPATHWAYS_20260610%WP2857%HOMO SAPIENS Mesodermal commitment pathway RARB BMPR1A AXIN2 PRKAR1A NOG SMAD6 TRIM28 SETD2 RPL38 ATP8B2 ACACA GATA3 CUL4B CRTC1 HES7 FGF8 WNT3A TBX6 PIAS1 SMAD4 NLK AEBP2 INHBA DNMT3B FOXA1 CCND1 TBX3 SESN1 AXIN1 FZD8 CCDC6 PPP2CA SMAD2 PLCH1 FOXC2 SNAI1 SOX17 ACVR1 DKK1 C1QBP PITX2 GDF3 HTT NODAL TEAD2 KLF4 CTBP2 SOX21 CEP250 WDHD1 FOXH1 ARID5B EMSY TCF4 ADAM19 TWSG1 WDFY2 BCORL1 FOXC1 TOX GATA6 MBTD1 EPB41L5 TBX1 UBR5 PBX3 HMGA2 ZFHX4 NABP2 LATS1 TRIM71 EXT1 BCAR2 LEF1 SCHIP1 EXT2 PHF6 CSRP2 C9orf72 ZIC2 ZIC3 TRIM5 HNF4A TCF7L1 JARID2 SMAD1 LEFTY1 SLC2A12 MSGN1 TET1 PARP8 TOX3 ARL4A HAND1 AHDC1 FOXA2 WDCP LEFTY2 ZNF462 ELP4 ZIC5 SOX2 FGFR1 NFE2L2 AMH WNT3 VAV3 BHLHB2 FZD5 FZD4 BMPR2 PBX1 RGS10 ACVR2B ACVR2A BMP7 MEIS1 YAP1 NR1B3 KLF5 BMP4 MIXL1 POU5F1 REGULATION OF SISTER CHROMATID SEPARATION AT THE METAPHASE ANAPHASE TRANSITION%WIKIPATHWAYS_20260610%WP4240%HOMO SAPIENS Regulation of sister chromatid separation at the metaphase anaphase transition PTTG1 MAD2L1 CDC20 CENPE STAG1 BUB1B SMC3 APC ESPL1 SMC1A MAD1L1 RAD21 MIRNA REGULATION OF DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260610%WP1530%HOMO SAPIENS miRNA regulation of DNA damage response CREB1 MRE11A RAD50 BAX CCNG1 RB1 CCND1 CHEK2 MYC CHEK1 H2AX HUS1B BBC3 TP53AIP1 PIDD1 CCND3 CCND2 SESN1 TLK2 TLK1 NBN APAF1 RFC1 SMC1A DDB2 PRKDC CCNE2 RRM2B FANCD2 CCNE1 CCNB3 CCNB2 CCNB1 PMAIP1 SFN ATRIP CDC2 GADD45B GADD45A CDK4 TNFRSF10B PML GADD45G CDK2 RAD52 CDK6 MDM2 RAD51 CDK5 ATM CYCS RAD17 ATR CDKN1A RAD1 CDKN1B RAD9A BRCA1 CASP9 CASP8 CASP3 NEUROGENESIS REGULATION IN THE OLFACTORY EPITHELIUM%WIKIPATHWAYS_20260610%WP5265%HOMO SAPIENS Neurogenesis regulation in the olfactory epithelium NOTCH1 ERBB4 LRP8 APP DAB1 CXCL12 MAP1B ID1 PLXND1 MYC AGRN PSEN1 NEUROG3 SOX2 FAIM GSK3B RTN4R HES1 NDEL1 ASCL1 MEF2C NTRK2 NRG1 NTRK3 STAT3 TCF4 MRE11A CDK5R1 NEUROD1 GHRL RET DISC1 VLDLR RTN4 KDM1A RELN GIG8 CDK5 TCF3 PAFAH1B1 NUMB IL17A MAP2 NTRK1 NGFR BDNF NGF 8P23 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260610%WP5346%HOMO SAPIENS 8p23 1 copy number variation syndrome HSPD1 NKX6-1 BMP1 MAPK1 MAPK3 TERT FDFT1 PDX1 TBX5 BLK HEL-S-130P NUMA1 PINX1 GATA4 HEPACAM2 CLDN23 C8orf7 SOX7 SLC35G5 TERF1 TLR4 TNKS PRSS55 AXIN1 NEIL2 PPP1R3B SLC2A4 SLBP CSTA MTMR8 RAF1 MTMR9 PRSS51 SGPL1 ERI1 MTMR6 S100A10 MCRS1 DEFB136 C8orf74 DEFB135 DEFB134 RP1L1 MFHAS1 MSRA FAM167A FCGR2B FCGR2A CGAS CILIOPATHIES%WIKIPATHWAYS_20260610%WP4803%HOMO SAPIENS Ciliopathies ARL3 AK7 DYNLT2B DYNC2LI1 SUFU PKHD1 NPHP1 NPHP3 PIBF1 CEP78 KIF7 NEK9 DCDC2 CPLANE1 TMEM231 DNAAF19 TMEM17 ARL2BP NME7 TMEM237 AHI-1 UNC119 DNAL1 INVS C2CD3 DNAAF11 TCTN3 TCTN2 TTC8 TMEM107 TCTN1 HYDIN CNGA1 CC2D2A OFD1 CCDC39 CEP164 DNAI2 CFAP52 XPNPEP3 WDR35 TOPORS RP1 BBS10 EVC CLUAP1 BBS12 TULP1 RP2 TMEM216 NME9 CCDC41 EFHC1 WDR51B ZMYND10 KIZ CFAP53 CNGB1 KATNIP DNAH6 CRX PKD1L1 RSPH9 CFAP298 ARL13B TMEM67 SDCCAG8 RAB23 KIAA0753 PDE6D POC1A RAB28 DNAI1 EVC2 TUB DYX1C1 PCARE SCLT1 OCRL RSPH3 RPGRIP1 PIK3R4 TTLL5 RSPH1 ALMS1 SPAG1 HYLS1 B9D1 CEP41 B9D2 ATXN10 TRIM32 TRAF3IP1 PLK4 CENPF INPP5E DYNC2I2 IFT172 IFT80 LZTFL1 IFT81 INTU HEL-S-296 BBS2 NEK8 BBS1 DRC1 FLCN BBIP1 ADCY6 ZIC2 MKS1 IFT27 USP9X IFT52 BBS9 ZNF423 BBS7 IFT57 CEP290 PKD1 BBS5 BBS4 IQCB1 IFT140 RP1L1 IFT43 GLI3 ODAD1 ODAD3 ODAD4 CEP19 CCDC28B MCIDAS TBC1D32 NEK1 NEK2 DYNC2H1 DNAAF3 CFAP418 DNAAF2 DNAJB13 CCDC40 DNAAF6 RPGRIP1L CFAP410 FAM161A TMEM138 GPR161 WDPCP CCNQ CCNO SMO CEP104 ANKS3 ARL6 DNAJB1 PRKACA FUSION IN FIBROLAMELLAR LIVER CANCER%WIKIPATHWAYS_20260610%WP5514%HOMO SAPIENS DNAJB1 PRKACA fusion in fibrolamellar liver cancer HDAC5 SIK3 SIK1 DNAJB1 SIK2 CREB1 HDAC7 GNAS CRTC2 IL3 SIGNALING%WIKIPATHWAYS_20260610%WP286%HOMO SAPIENS IL3 signaling ENPP3 PTPN6 CCR3 RAPGEF1 SOS1 CRKL INPP5D CSF2RB MAP2K1 YWHAQ SHC1 PIK3R2 MAPK8 HEL-S-1 PIK3R1 LYN MAPK1 CD69 CXCL8 MAPK3 RAF1 BAD IL5RA STAT3 PTPN11 JUN PIK3CD BCL2 GRB2 TGFB1 GAB2 VAV1 STAT5B IL3RA SYK CBL IL3 SRC FYN HRAS JAK1 BCL2L1 FOS TRANS SULFURATION ONE CARBON METABOLISM AND RELATED PATHWAYS%WIKIPATHWAYS_20260610%WP2525%HOMO SAPIENS Trans sulfuration one carbon metabolism and related pathways CDO1 GCLC CBS GPX2 GPX1 TYMS GPX3 GPX6 PEMT CHKA HEL-S-61p MAT1A CHDH CHPT1 DHFR MTHFD1 MTHFD2 MTHFD2L HEL-75 DNMT3L DNMT3B PSPH pcap SHMT1 CTH MTR HEL-S-51e GCLM GAD2 BAAT PSAT1 HEL-S-44 AHCYL2 AHCYL1 SLC25A48 HEL-S-64p PCYT1B BHMT2 GPX7 BCAT1 HEL-S-75p MTHFD1L HEL-S-182mP CEPT1 CHKB PCYT2 PHGDH AMT GAD1 ALDH7A1 BCAT2 GPX4 AGXT2 GLUCOSE METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260610%WP5211%HOMO SAPIENS Glucose metabolism in triple negative breast cancer cells PPM2C PFKP HEL-S-133P HEL-S-30 GENES RELATED TO PRIMARY CILIUM DEVELOPMENT BASED ON CRISPR %WIKIPATHWAYS_20260610%WP4536%HOMO SAPIENS Genes related to primary cilium development based on CRISPR ARL3 DYNLT2B DYNC2LI1 CEP97 IFT80 IFT74 PIBF1 LZTFL1 CPLANE1 IFT81 TMEM231 TMEM17 KIF3A C2CD3 TCTN3 TCTN2 TTC8 TMEM107 TCTN1 CC2D2A OFD1 WDR35 BBS2 DNCL1 BBS10 EVC BBS1 CLUAP1 BBS12 TMEM216 CCDC41 FUZ IFT20 ARL13B TMEM67 MKS1 RAB23 KIAA0753 IFT27 IFT25 EVC2 TTC26 SCLT1 IFT52 BBS9 B9D1 BBS7 IFT57 TRAF3IP1 BBS5 BBS4 CEP192 DYNLT1 IFT140 TTC23 CBY1 EFCAB7 IFT43 TXNDC15 CDK20 TRAPPC11 KIFAP3 CEP295 ARMC9 CEP19 CEP20 TEDC1 TEDC2 FBF1 KATNB1 IFT46 TUBD1 DYNC2H1 KIF3B INPP5E CEP76 RABL2B TUBE1 CPLANE2 MIB1 RPGRIP1L SASS6 IFT70B CEP162 CIBAR1 CEP44 DYNC2I2 WDPCP IFT172 CEP104 ARL6 AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20260610%WP699%HOMO SAPIENS Aflatoxin B1 metabolism CYP1A2 EPHX1 HEL-S-166mP CYP3A4 GSTM1 CYP2A13 EICOSANOID METABOLISM VIA CYCLOOXYGENASES COX %WIKIPATHWAYS_20260610%WP4719%HOMO SAPIENS Eicosanoid metabolism via cyclooxygenases COX AKR1B1 TBXA2R PTGDR PTGIR ACOX1 ACOX3 PLA2G6 CYP4F12 PPARG NR1C2 PTGIS PLA2G4B PLA2G5 PRXL2B PTGES EHHADH CYP4F2 CYP4A22 CYP4A11 PTGFR PTGS2 HEL-S-298 PTGR1 HPGD PTGS1 PTGDR2 MIRNAS INVOLVED IN DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260610%WP1545%HOMO SAPIENS miRNAs involved in DNA damage response CCNE1 CDKN1A CCND3 CDKN1B CCND1 CREB1 MYC RAD52 CDK6 H2AX ATM INITIATION OF TRANSCRIPTION AND TRANSLATION ELONGATION AT THE HIV 1 LTR%WIKIPATHWAYS_20260610%WP3414%HOMO SAPIENS Initiation of transcription and translation elongation at the HIV 1 LTR HDAC5 PPP3R2 NFATC3 NFATC2 NFATC1 SUPT4H1 PPP3R1 NELFA HDAC8 PPP3CA NELFE HEXIM1 SUPT5H NFATC4 NFKB1 NELFCD PPP3CC EP300 SP1 NELFB RELA NFKBIA HDAC3 HDAC2 CDK9 CREBBP HDAC7 HDAC1 PEROXISOMAL BETA OXIDATION OF TETRACOSANOYL COA%WIKIPATHWAYS_20260610%WP1941%HOMO SAPIENS Peroxisomal beta oxidation of tetracosanoyl CoA ACOX1 HSD17B4 OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20260610%WP623%HOMO SAPIENS Oxidative phosphorylation NDUFA9 NDUFA5 COXFA4L2 NDUFA11 ATP5G1 HEL-S-271 NDUFC2 NDUFC1 NDUFS6 NDUFS5 NDUFS4 NDUFS1 ND3 ND2 ND5 ND4 NDUFB9 ND6 NDUFB8 NDUFB7 NDUFB6 NDUFB5 NDUFB4 ATP6 ATP5MC2 NDUFB2 ATP5J NDUFB10 NDUFB1 ATP5MC3 ATP5H HEL-S-123m NDUFV3 NDUFV2 ATP5MG ATP5MF ATP5ME NDUFA10 DMAC2L NDUFA7 NDUFA6 ATP5PB NDUFA3 NDUFA2 ND4L ATP5F1D ATP5F1E NDUFAB1 ATP5PO NDUFS8 NDUFS3 ND1 COXFA4 ATP6AP2 NANOPARTICLE MEDIATED ACTIVATION OF RECEPTOR SIGNALING%WIKIPATHWAYS_20260610%WP2643%HOMO SAPIENS Nanoparticle mediated activation of receptor signaling MAPK10 ITGA1 SOS1 MAP2K1 ITGB1 COL1A1 MAP2K2 MAPK8 NRAS MAPK1 RAF1 EGFR PXN AKT3 MAPK14 AREG PIK3CD MAPK9 GRB2 MAPK12 MAPK13 MAPK11 SRC HRAS TLN1 NPHP1 DELETION SYNDROME%WIKIPATHWAYS_20260610%WP5399%HOMO SAPIENS NPHP1 deletion syndrome INVS NPHP1 MAPK1 PTK2B RPGRIP1L MAPK3 FLNA FLNB APOPTOSIS%WIKIPATHWAYS_20260610%WP254%HOMO SAPIENS Apoptosis MAPK10 CASP2 BOK IRF-1 IRF4 HRK PRF1 CASP4 HELLS NFKBIE SCAF11 IRF2 CRADD BCL2L2 TRADD BAD TRAF1 CDKN2A TNF IKBKB IKBKG CHUK BAX BCL2L11 TRAF2 IRF3 TRAF3 RELA IRF7 TP63 IRF6 RIPK1 IGF1R FADD MAP3K1 BCL2L1 MCL1 MAP2K4 DIABLO MYC BBC3 IGF1 NFKBIB BIRC5 PIK3R1 NFKB1 APAF1 LTA TNFRSF1B TNFRSF25 BIRC2 TNFRSF21 BIRC3 JUN PMAIP1 IGF2 TNFRSF10B BCL2 MDM2 CASP6 NFKBIA CASP10 BAK1 CYCS TP73 TNFSF10 BNIP3L DFFB CASP9 DFFA CASP8 CASP3 TNFSF6 TNFRSF1A REGUCALCIN IN PROXIMAL TUBULE EPITHELIAL KIDNEY CELLS%WIKIPATHWAYS_20260610%WP4838%HOMO SAPIENS Regucalcin in proximal tubule epithelial kidney cells TRPV5 PIK3CA PPP3R1 MAP3K5 PTH FFAR3 MAPK1 SEC16B HEL-S-41 TGFBR1 APAF1 RAF1 CALCA SMAD2 MTOR ACTA2 BAX MCU PDE1B TGFB1 BAK1 CASP9 CASP8 CASP3 SMAD4 TNFSF11 TNFRSF1A PROSTAGLANDIN AND LEUKOTRIENE METABOLISM IN SENESCENCE %WIKIPATHWAYS_20260610%WP5122%HOMO SAPIENS Prostaglandin and leukotriene metabolism in senescence RB1 GNAS NRAS PTGER1 PTGER2 PTGER3 PTGIS GNAI1 ALOX15 ALOX12 ALOX15B PRXL2B IGFBP5 PTGES ADCY3 CDKN1A ALOX5 MAPK11 PTGER4 HRAS ALOX5AP SIRT1 LTC4S PTGS2 PTGS1 SARS COV 2 AND COVID 19 PATHWAY%WIKIPATHWAYS_20260610%WP4846%HOMO SAPIENS SARS CoV 2 and COVID 19 pathway TLR7 SCARB1 TMPRSS2 CTSL SLC6A19 FURIN ACAT1 ACE2 NRP1 TMPRSS4 CELLULAR PROTEOSTASIS%WIKIPATHWAYS_20260610%WP4918%HOMO SAPIENS Cellular proteostasis VBP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 MELANOMA%WIKIPATHWAYS_20260610%WP4685%HOMO SAPIENS Melanoma PIK3CA ERBB4 SOS1 ARHA PAK1 MAPK1 E2F3 MAPK3 BAD ARAF CDKN2A CALML6 AKT3 CALML3 PTPN11 CALML4 PREX2 WHR1 PDE5A BAX KIT HEL114 SOS2 PIK3CD KDR RB1 CCND1 MAP2K1 NF1 MAP2K2 SHC2 PIK3R3 PIK3R2 GRM3 PIK3R1 E2F2 NRAS RAF1 DDB2 POLK EXOC7 GADD45B GADD45A CDK4 GADD45G CDK6 MDM2 GRB2 CALM1 BAK1 CDKN1A PTEN HRAS RHOB RAC1 PRADER WILLI AND ANGELMAN SYNDROME%WIKIPATHWAYS_20260610%WP3998%HOMO SAPIENS Prader Willi and Angelman syndrome LHB TUBGCP5 NIPA1 TUBGCP6 TUBGCP4 NIPA2 POM121 GNRH1 ATP10A CDKN2B CDKN2A NUP88 HERC2 NUP62 AHCTF1 NUP188 NPAP1 PCM1 RNF8 NUP214 NDC1 GOLGA8S SNRPN NUP210 GOLGA6L2 TACR3 NUP93 FEZ1 FEZ2 NUP98 GABRG3 SNURF GABRG1 NUP54 NUP58 OCA2 NUP205 SLC45A2 NGF MAGEL2 SEH1L EIF4E DLX5 AAAS NUP160 NHLH2 RAE1 DKFZp781B1423 NUP42 NUP85 CYFIP1 FMR1 TPR MSX1 RANBP2 NUP155 GABRB3 NUP153 RB1 PRKCZ CDC6 KISS1 POMC GHRH CCND1 NUP35 MKRN3 CDKN2C NUP107 GABRR3 PCSK1 GABRR1 BBS4 CCND2 NUP133 UBE3A OXT GHRL TYR CDK4 INS NDN CDK6 MDM2 GABRA5 HEL-S-71 FSHB CGA BDNF NEUROTRANSMITTER DISORDERS%WIKIPATHWAYS_20260610%WP4220%HOMO SAPIENS Neurotransmitter disorders MAOA TPH2 DDC SLC18A2 TPH1 SLC6A3 PNMT DBH TH TYPE II INTERFERON SIGNALING%WIKIPATHWAYS_20260610%WP619%HOMO SAPIENS Type II interferon signaling IFNB1 STAT2 IRF-1 IRF4 IFI6 GBP1 CYBB PSMB9 IL1B IRF2 IRF8 CXCL9 IFNGR1 HLA-B SPI1 IFNGR2 STAT1 MHC2TA IFIT2 PTPN11 NOS2 EIF2AK2 IFNA2 H4C9 OAS1 IRF9 SOCS3 SOCS1 JAK1 ISG15 IFNG PROSTAGLANDIN SIGNALING%WIKIPATHWAYS_20260610%WP5088%HOMO SAPIENS Prostaglandin signaling IL6 IL1B PYCARD KLRD1 CXCL9 CSF1 CCR2 NFKB1 CXCL8 PTGER2 CXCL1 TNF AREG PTGES AHR IL12A TGFB1 IFNA1 IRF7 IL17F IL17A PTGER4 CCL3 IL1A CCL2 MMP9 IFNG VEGFA NLRP3 CLOCK CONTROLLED AUTOPHAGY IN BONE METABOLISM%WIKIPATHWAYS_20260610%WP5205%HOMO SAPIENS Clock controlled autophagy in bone metabolism CTSK TNFRSF11B SP7 NOTCH1 ATG101 DKFZp762B153 CSF1 CTF1 MTOR HMGB1 SOST TRAF6 VCP CTHRC1 SMAD1 IL3 SMAD4 RUNX2 EFNB2 PER1 CRY1 NFATC1 ATG3 SMAD9 ATG10 IL6 ATG12 SQSTM1 DKFZp686F0183 DKFZp781O1323 ATG16L1 IGF1 BHLHE41 PTH RORB BMP6 ARHGAP4 FYCO1 WNT16 BMP3 RB1CC1 NPAS2 DRAM2 SEMA4D NR1D2 LEP PLEKHM1 ULK1 WNT10B BHLHB2 CALCA BMPR2 AMBRA1 PRKAA2 BCL2 TGFB1 LAMP2 LRP5 TNFRSF11A DKK1 BMP5 BMP4 BMP2 MAP1LC3A SEMA3A TNFSF11 GLYCINE METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260610%WP5028%HOMO SAPIENS Glycine metabolism including IMDs GLDC SHMT1 AMT NFU1 HEL-S-302 DLD HSCB ISCU LIPT2 LIPT1 LIAS GCSH BOLA3 7 OXO C AND 7 BETA HC PATHWAYS%WIKIPATHWAYS_20260610%WP5064%HOMO SAPIENS 7 oxo C and 7 beta HC pathways ACOT8 NPC2 ACOT7 EPHX2 ACOT11 ACOT12 ACOT13 SLC27A2 EBP AMACR DBP THEM5 ACOT6 BAAT CYP7A1 ACOT4 DHCR7 SLC27A5 CYP27A1 HSD11B1 HSD11B2 ACOT9 NPC1 OSTEOBLAST DIFFERENTIATION AND RELATED DISEASES%WIKIPATHWAYS_20260610%WP4787%HOMO SAPIENS Osteoblast differentiation and related diseases MAPK10 JAG2 NOTCH1 BMPR1A IHH DLL3 DLL4 PTCH1 PRKD1 PIK3CD FGF8 WNT3A SOX9 SMAD4 RUNX2 HEY2 FGFR4 PIK3R4 FZD7 HES6 FZD8 PRKDC PRKCE MAPK9 MAPK7 MAPK6 MAPK4 LRP5 PIK3R5 MAPK12 LRP6 MAPK13 MAPK11 FZD1 NOTCH3 NOTCH4 RBPJ PIK3CA FGF3 FGF4 FGF6 FGF7 FGF9 MYOD1 MAPK8 MAPK1 MAPK3 STAT1 MAPK14 FGF18 FGF10 SMAD1 FGF2 PIK3C2G PIK3C2B PRKCB PRKCI FGFR2 PRKCH PRKCA PRKCQ SMAD9 PRKCZ DKFZp781O1323 FGFR1 WNT2B FZD10 PIK3R3 PIK3R2 WNT5B PIK3R1 WNT9B WNT9A WNT16 WNT8A WNT8B WNT3 WNT4 PPARG WNT10B WNT10A FZD3 FZD5 FZD4 WNT7B FZD9 FGFR3 WNT7A NOTCH2 BMPR2 GLI3 HES3 HES2 BMP4 BMP2 WNT1 SMO FZD2 SMALL LIGAND GPCRS%WIKIPATHWAYS_20260610%WP247%HOMO SAPIENS Small ligand GPCRs TBXA2R PTGDR PTGIR S1PR1 LPAR1 S1PR2 S1PR3 S1PR4 GPR50 CNR2 PTGER1 PTGER2 PTGER3 PTGER4 CNR1 PTGFR MTNR1A MTNR1B REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20260610%WP51%HOMO SAPIENS Regulation of actin cytoskeleton ITGA1 MYL1 ARPC5 MYL3 GNA13 APC ARHGEF1 PIK3CD FGF8 VAV1 GNG12 FGFR4 RDX FGF16 EZR HEL70 PIK3R4 HEL-S-15 MAP2K1 MAP2K2 MOS RRAS2 ACTN1 RAF1 STM7 PXN PIP5K1A PIP4K2B PDGFA FGF13 FGF12 MAPK6 MAPK4 PIK3R5 F2R F2 RAC1 RASSF7 PIK3CA CHRM1 SOS1 FGF3 CRK FGF4 DOCK1 FGF6 CDC42 FGF7 FGF9 ARHA PAK1 CFL2 MAPK1 FGF20 FGF22 MAPK3 IQGAP1 FGF21 FGF17 EGFR FGF14 RRAS FGF19 FGF18 FGF10 HEL114 SOS2 TMSB4X ARHGAP35 MYLK CD14 PDGFRA BAIAP2 ARHGEF7 LIMK1 FGF2 PIK3C2G PIK3C2B WAS FGFR2 PIP4K2A APC2 PIP5K1C PFN1 EGF CHRM2 FGFR1 PIK3R3 PIK3R2 PIK3R1 NRAS RAC3 FGF23 FGFR3 ROCK1 ROCK2 PAK6 ACTG1 PAK4 CYFIP2 PS1TP5BP1 CHRM3 NCKAP1 CHRM4 CHRM5 MYH10 SSH2 SSH3 SSH1 BRK1 PIP5KL1 ARHGEF4 BDKRB2 FGD1 BDKRB1 CSK WASF1 WASF2 ABI2 SARS COV 2 MITOCHONDRIAL CHRONIC OXIDATIVE STRESS AND ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260610%WP5183%HOMO SAPIENS SARS CoV 2 mitochondrial chronic oxidative stress and endothelial dysfunction ACAD9 NDUFAF2 TOMM70 TERF2IP NDUFAF1 SIRT6 MAVS RPS6KA1 IL6 ECSIT ACE2 TRAF3 REN TRAF6 MITA NFKB1 IL18 TERF2 TNF NLRX1 NLRP3 FUMARATE HYDRATASE DEFICIENT PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260610%WP4241%HOMO SAPIENS Fumarate hydratase deficient papillary renal cell carcinoma CTSK EGLN3 EP300 EGLN2 CADM2 PRCC RBX1 SFPQ COL21A1 ELOC BIRC7 TGFA TGFB1 EGLN1 CDKN1A VHL CREBBP FH SETD2 TFEB DVL2 HIF1A VEGFA PROTEOGLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260610%WP4784%HOMO SAPIENS Proteoglycan biosynthesis XYLT1 CSGALNACT1 EXT1 SLC35B2 SLC26A2 EXT2 CANT1 B3GAT3 XYLT2 B3GALT6 CHSY1 BPNT2 CHST14 CHST3 PAPSS2 ERYTHROPOIESIS%WIKIPATHWAYS_20260610%WP5607%HOMO SAPIENS Erythropoiesis CD34 EPO KIT HBB HBA2 TF TFRC GDF11 IL3RA HBZ HBG2 IL3 HBG1 CD79A HBE1 HBD GATA1 TNFSF6 EPOR GATA2 PTPRC KITLG NON HOMOLOGOUS END JOINING%WIKIPATHWAYS_20260610%WP438%HOMO SAPIENS Non homologous end joining XRCC5 POLM POLL NHEJ1 WRN PRKDC 2Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260610%WP5221%HOMO SAPIENS 2q11 2 copy number variation syndrome ERBB2 DUSP2 ARHA MAPK1 CIAO2B MAPK3 ANKRD39 PARL CIAO1 COL2A1 ITPRIPL1 TMEM127 CNNM3 CNNM4 FER1L5 STARD7 SEMA4C ANKRD23 ARID5A ASTL NEURL3 KANSL3 PLXNB2 MMS19 SNRNP200 ZP2 ADRA2B CIAO2A COX11 IRINOTECAN PATHWAY%WIKIPATHWAYS_20260610%WP229%HOMO SAPIENS Irinotecan pathway BCHE SLCO1B1 UGT1A1 UGT1A9 ABCC1 CYP3A4 ABCC2 UGT1A10 CES2 ABCG2 CES1 CALCIUM MEDIATED T CELL APOPTOSIS INVOLVED IN INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260610%WP5142%HOMO SAPIENS Calcium mediated T cell apoptosis involved in inclusion body myositis PPP3CC PLCG1 NFATC2 EP300 CD8B PPP3CA CD8A MEF2D ITPRIP ATP2A1 CABIN1 CALM1 ZAP70 LCK HDAC2 HDAC1 MITOCHONDRIAL IMMUNE RESPONSE TO SARS COV 2%WIKIPATHWAYS_20260610%WP5038%HOMO SAPIENS Mitochondrial immune response to SARS CoV 2 ACAD9 TOMM70 IKBKE NDUFAF1 TMPRSS2 MAVS ECSIT RIGI REN NFKB1 NFKB2 NLRX1 TBK1 TICAM1 PHB2 ACE2 IRF3 IFIH1 TRAF3 TLR3 TRAF6 CGAS IRF7 AGTR1 MITA TLR7 AGTR2 NDUFB9 CTSL AMPLIFICATION AND EXPANSION OF ONCOGENIC PATHWAYS AS METASTATIC TRAITS%WIKIPATHWAYS_20260610%WP3678%HOMO SAPIENS Amplification and expansion of oncogenic pathways as metastatic traits CYTIP TCF7L2 VHL TCF7L1 NOTCH1 CXCR4 TNC SRC LEF1 VEGFA POSTN VCAM1 PPAR ALPHA PATHWAY%WIKIPATHWAYS_20260610%WP2878%HOMO SAPIENS PPAR alpha pathway CDC2 UGT1A9 CCND1 CDK4 CYP7A1 MYC PLTP CYP8B1 CPT2 APOA2 APOC3 EHHADH APOA5 SLC27A1 CPT1A RXRA NR1H3 ACADM DBI CYP4A11 FABP1 NR1C1 KLK15 LAMIN A PROCESSING PATHWAY%WIKIPATHWAYS_20260610%WP4299%HOMO SAPIENS Lamin A processing pathway LMNA ZMPSTE24 ICMT GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260610%WP661%HOMO SAPIENS Glucose homeostasis INS TYPE III INTERFERON SIGNALING%WIKIPATHWAYS_20260610%WP2113%HOMO SAPIENS Type III interferon signaling IFNLR1 IL10RB STAT2 IFNL2 IRF9 IFNL1 STAT1 IFNL3 JAK1 TYK2 PAFAH1B1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260610%WP5409%HOMO SAPIENS PAFAH1B1 copy number variation DYNC1H1 PAFAH1B1 NDEL1 TUBA1A HEL-S-303 VLDLR NUDC RELN NON GENOMIC ACTIONS OF 1 25 DIHYDROXYVITAMIN D3%WIKIPATHWAYS_20260610%WP4341%HOMO SAPIENS Non genomic actions of 1 25 dihydroxyvitamin D3 CAMK2A PLCB3 PLCB4 RELB PLCB1 PLCB2 MAPK8 RXRA MAPK1 CXCL8 CAMK2D MAPK3 IFNGR1 IFNGR2 STAT1 TNF IKBKB MAPK14 IFNAR2 TYK2 IFI27L2 MED1 RSAD2 OAS2 NOD2 CCL2 ISG15 PRKCB PRKCH STAT2 PRKCA PRKCQ NR1i1 PRKCZ IL6 PLCG2 TLR4 NRAS NFKB1 NFKB2 CYP27B1 CYP24A1 CD40 PLCE1 CD40LG PRKCE CAMK2G JUN RXRB RXRG SP1 TLR8 MAPK9 SP3 MAPK7 IFNA2 CAMP MAPK12 MAPK13 DEFB4B MAPK11 HRAS JAK1 IFNG TNFRSF1A APOE AND MIR 146 IN INFLAMMATION AND ATHEROSCLEROSIS%WIKIPATHWAYS_20260610%WP3926%HOMO SAPIENS ApoE and miR 146 in inflammation and atherosclerosis TLR4 NFKB2 APOE SPI1 IRAK1 RELA TRAF6 COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260610%WP558%HOMO SAPIENS Complement and coagulation cascades CLU C3AR1 CR1 PLAT F3 CD46 CFH C1QA CFI C5AR1 THBD SERPIND1 CR2 HEL-S-62p SERPINA1 SERPINF2 PLAUR F5 F8 F9 CPB2 SERPINC1 TFPI LMAN1 F10 PROC F7 PLG HEL-S-78p VWF C4B_2 C1QB CFD C1S F13B C6 CLTC C8G C7 F2R C9 MASP2 MASP1 F2 CFB CD55 KNG1 C1QC BDKRB1 SERPING1 KLKB1 PROS1 INTRAFLAGELLAR TRANSPORT PROTEINS BINDING TO DYNEIN%WIKIPATHWAYS_20260610%WP4532%HOMO SAPIENS Intraflagellar transport proteins binding to dynein WDR35 DYNLT2B DYNLL2 DYNC2LI1 DNCL1 DYNC1LI2 IFT43 DYNC1I1 IFT80 DYNC1LI1 IFT81 IFT46 DYNC2H1 DYNC1H1 IFT22 DYNC2I2 IFT27 DYNLRB2 DYNLT1 IFT25 IFT140 DYNLT3 TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20260610%WP465%HOMO SAPIENS Tryptophan metabolism GOT2 HAAO CYP1A1 IL4I1 TDO2 DDC ALDH2 AFMID AOC1 KYAT3 KYAT1 IDO2 ALDH8A1 KYNU KMO TPH2 ECHS1 TPH1 STAT1 AOX1 AHR INMT MAOA ASMT DLD AANAT GCDH ACAT1 AADAT IDO1 FOXA2 PATHWAY%WIKIPATHWAYS_20260610%WP5066%HOMO SAPIENS FOXA2 pathway ACACA FOXA1 MTTP FASN APOB ABCC3 IRS1 ABCC2 INS SLC27A5 GSTM2 SLCO1B1 FOXO1 MLXIPL PPARGC1B FOXA2 MSMP EXPRESSION REGULATION IN CANCER CELLS AND ITS PRO ANGIOGENIC ROLE IN OVARIAN TUMORS%WIKIPATHWAYS_20260610%WP4397%HOMO SAPIENS MSMP expression regulation in cancer cells and its pro angiogenic role in ovarian tumors MSMP CCR2 CTCF EICOSANOID METABOLISM VIA LIPOOXYGENASES LOX %WIKIPATHWAYS_20260610%WP4721%HOMO SAPIENS Eicosanoid metabolism via lipooxygenases LOX ALOX15 ALOX12 TRPA1 ALOX15B ACOX1 TRPV1 ACOX3 CYP4F12 EHHADH KPG_011 CYP4F2 CYP4A22 FPR2 ALOX5 CYP4A11 NR1C1 LTC4S HEL-S-298 PTGR1 NR1C2 LTB4R HPGD CAFFEINE IN NEURONS%WIKIPATHWAYS_20260610%WP5602%HOMO SAPIENS Caffeine in neurons ADRA1A ADORA2A ADRA1D ADRA1B INHIBITION OF EXOSOME BIOGENESIS AND SECRETION BY MANUMYCIN A IN CRPC CELLS%WIKIPATHWAYS_20260610%WP4301%HOMO SAPIENS Inhibition of exosome biogenesis and secretion by manumycin A in CRPC cells RAB27A RAB5A PDCD6IP RRAS2 HGS NRAS HNRNPH1 MAPK1 MAPK3 RAF1 HRAS ARAF RAB5B RAB5C RRAS ENDOCHONDRAL OSSIFICATION WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260610%WP4808%HOMO SAPIENS Endochondral ossification with skeletal dysplasias PTH1R BMPR1A IHH PLAT CDKN1C ADAMTS4 ADAMTS5 MGP NKX3-2 FRZB SOX6 SOX5 CAB39 PTHLH CST5 KIF3A HMGCS1 STAT1 GH1 PTCH1 FGF18 GHR ACAN COL10A1 STAT5B SOX9 FGF2 RUNX2 MMP9 IGF1R VEGFA TIMP3 DDR2 FGFR1 IGF1 PTH CHST11 BMP6 opn RUNX3 MEF2C THRA ALPL ENPP1 COL2A1 FGFR3 SCIN GLI3 IGF2 TGFB1 CALM1 BMP7 FABP4 IN OVARIAN CANCER%WIKIPATHWAYS_20260610%WP4400%HOMO SAPIENS FABP4 in ovarian cancer HEL-S-104 RAC1 PAK1 P38 MMP2 PATHWAY%WIKIPATHWAYS_20260610%WP3303%HOMO SAPIENS RAC1 PAK1 p38 MMP2 pathway PIK3CA SOS1 CRK ITGB1 MAPK8 PAK1 MAPK1 MAPK3 EGFR BAD STAT3 IKBKB PTPN11 MAPK14 IKBKG CHUK BAX RELA STAT5B ANGPT4 ANGPT1 SRC ANGPT2 ERBB2 MMP2 MYC NCK1 BIRC5 PIK3R1 FOXO1 GRB14 NRAS RS1 GRB7 NFKB1 MSH2 ANGPTL1 TNIP2 TNIP3 PXN EIF4EBP1 NOS2 MAPK9 NFKBIA RAD51 GRB2 YAP1 MAPK12 CASP9 MAPK13 MAPK11 HRAS RAC1 AUTOPHAGY%WIKIPATHWAYS_20260610%WP4923%HOMO SAPIENS Autophagy ATG3 PIK3R4 ATG12 DKFZp686F0183 PRKAB2 DEPTOR ATG16L1 ATG101 PRKAB1 WIPI2 DKFZp762B153 PRKAA1 ATG14 ATG9A AKT1S1 RB1CC1 MLST8 ULK1 PRKAG1 PRKAG2 PRKAG3 AMBRA1 MTOR PRKAA2 RPTOR UVRAG SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP %WIKIPATHWAYS_20260610%WP3391%HOMO SAPIENS Senescence associated secretory phenotype SASP H2AC6 CDKN2D H2BC12 MAPK1 CXCL8 MAPK3 CDKN2B H2AZ2 H2AB1 CDKN2A STAT3 H2AJ ANAPC1 CCNA2 EHMT1 H3C15 RELA H3C8 UBE2E1 H4C9 H3F3B HIST1H4L RPS27A UBB UBC RPS6KA2 RPS6KA1 IL6 CDKN2C H2AX UBE2C CEBPB H2AZ1 NFKB1 H2AC19 UBE2D1 CDC23 H2AC14 H2BC26 H2BC12L H2BC21 CDC26 CDC27 HIST1H2AB VENTX JUN ANAPC7 H2BC17 H2BC13 H2BC14 H2BC15 CDK4 H2BC11 HIST1H2BE ANAPC5 CDK2 ANAPC2 ANAPC15 CDK6 ANAPC10 MAPK7 ANAPC11 FZR1 C10orf104 CDKN1A H2BC9 CDKN1B H2BC8 H2BC3 H2BC1 UBE2S IGFBP7 H2AC20 IL1A FOS OVERLAP BETWEEN SIGNAL TRANSDUCTION PATHWAYS CONTRIBUTING TO LMNA LAMINOPATHIES%WIKIPATHWAYS_20260610%WP4879%HOMO SAPIENS Overlap between signal transduction pathways contributing to LMNA laminopathies TNFRSF11B CTSK KAT2B HES5 NOTCH1 RB1 MSTN CSNK1A1 GSK3B MYOD1 HES1 CEBPB CEBPD opn AXIN1 PPARG WNT10B APC WNT7B SMAD2 DICER1 CEBPA HMGA2 CDK4 LEF1 ZMPSTE24 PS1TP5BP1 EMD TGFB1 MAOA LEMD3 CDKN1A LMNA TCF7L2 TCF7L1 JUNB CSNK1A1L CREBBP TARBP2 AGO2 RUNX2 FNTA BMP2 HDAC1 ICMT HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CARCINOMA PATHWAY%WIKIPATHWAYS_20260610%WP4206%HOMO SAPIENS Hereditary leiomyomatosis and renal cell carcinoma pathway PDHA1 ACACB ACACA HEL-S-133P KEAP1 PRKAB1 PRKAA1 EGLN1 NFE2L2 SLC11A2 RPS6 PDHA2 HIF1A PRKAG1 VEGFA VITAMIN A1 AND A5 X PATHWAYS%WIKIPATHWAYS_20260610%WP5397%HOMO SAPIENS Vitamin A1 and A5 X pathways RARB RXRA RXRB NR1B3 RXRG RARA METABOLISM OF DICHLOROETHYLENE BY CYP450%WIKIPATHWAYS_20260610%WP3666%HOMO SAPIENS Metabolism of dichloroethylene by CYP450 CYP2E1 T CELL RECEPTOR AND CO STIMULATORY SIGNALING%WIKIPATHWAYS_20260610%WP2583%HOMO SAPIENS T cell receptor and co stimulatory signaling PLCG1 PTPN6 NFATC2 PRKCA CD8B PPP3CA CD8A CSNK1A1 GSK3B IL2 NFKBIA CALM1 ZAP70 LCK PDCD1 PTEN NFKB1 ITK FYN GSK3A DYRK2 DYRK1A CTLA4 ACTIVATION OF NLRP3 INFLAMMASOME BY SARS COV 2%WIKIPATHWAYS_20260610%WP4876%HOMO SAPIENS Activation of NLRP3 inflammasome by SARS CoV 2 NFKB1 TRAF3 RELA IL1B NLRP3 PYCARD SEROTONIN AND ANXIETY RELATED EVENTS%WIKIPATHWAYS_20260610%WP3944%HOMO SAPIENS Serotonin and anxiety related events PRKCB PLEK HTR1A HTR2A PPP3CA ARC CRH PLCD4 NLGN1 FOS ROLES OF CERAMIDES IN DEVELOPMENT OF INSULIN RESISTANCE%WIKIPATHWAYS_20260610%WP5181%HOMO SAPIENS Roles of ceramides in development of insulin resistance PPP2CA PRKCZ IRS1 EIF2AK2 INS PDX1 MAPK8 PIK3R1 INSR SLC2A4 ACSL1 TRAF1 ERN1 TNF CD36 MAFA PRKAG3 TNFRSF1A RPS6KB1 JAK STAT SIGNALING IN THE REGULATION OF BETA CELLS%WIKIPATHWAYS_20260610%WP5358%HOMO SAPIENS JAK STAT signaling in the regulation of beta cells EPO IL6 PRLR CCND3 NRAS CCND2 AKT1S1 MLST8 IFNGR1 IFNGR2 STAT1 GH1 STAT3 AKT3 MTOR IL6R GHR CDK4 STAT5B FOXM1 RPTOR SOCS3 SOCS1 PRL HRAS CISH IFNG EPOR SOCS2 AMYOTROPHIC LATERAL SCLEROSIS ALS %WIKIPATHWAYS_20260610%WP2447%HOMO SAPIENS Amyotrophic lateral sclerosis ALS DERL1 HEL-S-2 NEFH PPP3CA NEFL MAP3K5 MAP2K2 HEL-S-44 APAF1 BAD GPX1 TNF TOMM40 PPP3CC MAPK14 BAX BCL2 RAB5A CASP9 SLC1A2 CASP3 CCS CASP12 MAP2K6 NEF3 RAC1 SMIM40 BCL2L1 TNFRSF1A NAD BIOSYNTHETIC PATHWAYS%WIKIPATHWAYS_20260610%WP3645%HOMO SAPIENS NAD biosynthetic pathways SIRT4 TNKS2 SIRT6 SIRT7 NAPRT NMNAT1 TDO2 SIRT5 PARP4 SIRT2 SIRT3 NAMPT TNKS BST1 NADSYN1 SIRT1 PARP2 HEL-S-90n IDO1 UTERINE NATURAL KILLER CELLS AND PROGESTERONE ESTROGEN AND CHORIONIC GONADOTROPIN%WIKIPATHWAYS_20260610%WP5569%HOMO SAPIENS Uterine natural killer cells and progesterone estrogen and chorionic gonadotropin MRC1 NR3C1 GAB3 PIBF1 NCR1 NCR2 NCR3 KIR2DL4 SELL CX3CL1 VCAM1 ITGA4 MADCAM1 CXCR4 CXCL8 MAPK3 TNF PGR IL10 STAT5B IL3 JAK3 CCL5 ANGPT1 CCL4 ANGPT2 CCL3 CCL2 CXCR3 VEGFA MCL1 MAP2K4 IL6 CXCL11 CXCL12 CD69 NR3A2 HLA-G IL2RG GATA2 IL2RB CCL8 CCL7 BCL2 IL4 IL15RA MAPK11 JAK1 IFNG IL1 SIGNALING%WIKIPATHWAYS_20260610%WP195%HOMO SAPIENS IL1 signaling PLCG1 MAP2K4 REL MYD88 PRKCZ ECSIT SQSTM1 HSPB2 MAP2K1 MAPKAPK2 MAP2K2 IL1B PIK3R2 MAPK8 TAB3 NFKBIB PIK3R1 MAPK1 NFKB1 MAPK3 MAP3K14 ATF2 PELI1 IKBKB IRAK2 MAP3K7IP1 IRAK3 PTPN11 MAPK14 IKBKG JUN CHUK IRAK4 MAP2K3 RELA MAPK9 NFKBIA TRAF6 MAP3K2 MAP3K7 HEL-S-71 IL1R1 UBE2V1 IL1A IRAK1 MAP2K6 MAP3K1 SULFATASE AND AROMATASE PATHWAY%WIKIPATHWAYS_20260610%WP5368%HOMO SAPIENS Sulfatase and aromatase pathway SLCO1B1 HSD17B1 HSD17B2 SULT1E1 NR3A2 SLCO4A1 SLCO1A2 HSD17B3 SLCO2B1 SLCO4C1 HSD3B1 IMATINIB AND CHRONIC MYELOID LEUKEMIA%WIKIPATHWAYS_20260610%WP3640%HOMO SAPIENS Imatinib and chronic myeloid leukemia PIM1 PIM2 KIT SKP2 GADD45A CSF1R MYC ABCB1 NOP2 GAB2 BCR LYL1 CDKN1B PDGFRA FLT1 FOXO3A ABCG2 CLEAR CELL RENAL CELL CARCINOMA PATHWAYS%WIKIPATHWAYS_20260610%WP4018%HOMO SAPIENS Clear cell renal cell carcinoma pathways HEL-S-87p ENPP3 PFKM BAP1 PFKP DEPTOR KDM5C EFCAB3 PBRM1 AKT1S1 RAPGEF5 SDSL PGBD5 LDHD SSPN SETD2 EGFR STAT3 ACACB ACACA ACLY MTOR EP300 FASN KCNJ2 HEL-S-162eP VHL PDGFRA CREBBP FLT1 HEL-S-30 ENO1 HIF1A HK3 VEGFA KDR PSPH SHMT1 HEL-S-51e HEL-S-133P HEL-S-68p SQSTM1 MAP2K5 PFKL PSAT1 CEP290 ALDOB BHLHE41 TSC2 KSR1 TSC1 GRB10 MLST8 CAMK1 PGM2 ENO2 ENO3 HK2 RHEB PHGDH PLOD2 PTEN RPTOR PKLR HEL-S-32 ME1 HEL-S-281 HEL-S-49 LET 7 INHIBITION OF ES CELL REPROGRAMMING%WIKIPATHWAYS_20260610%WP3299%HOMO SAPIENS let 7 inhibition of ES cell reprogramming EGR1 MYC KLF4 TRIM71 POU5F1 SOX2 BIOMARKERS FOR PYRIMIDINE METABOLISM DISORDERS%WIKIPATHWAYS_20260610%WP4584%HOMO SAPIENS Biomarkers for pyrimidine metabolism disorders DPYS DPYD DHODH HEL74 TYMP UMPS HEL-S-29 RRM1 NT5C3A TYMS RRM2 RRM2B STEROL REGULATORY ELEMENT BINDING PROTEINS SREBP SIGNALING%WIKIPATHWAYS_20260610%WP1982%HOMO SAPIENS Sterol regulatory element binding proteins SREBP signaling PIK3CA NFYA MBTPS2 MED15 CREB1 SEC23A PRKAA1 HMGCS1 YY1 NR1H2 DBI FGF21 SAR1A INSIG1 DKFZp434B2017 RNF139 SEC23B SEC31B SEC31A CYP51A1 CDK8 ACACA SEC24C ACLY MTOR SCARB1 SCD HMGCR FASN ACSS1 LDLR FDFT1 SQLE SIRT1 GPAM PRKAB2 FDPS PRKAB1 LPL PPARG GSK3A LPIN1 PRKAG1 PRKAG2 PRKAG3 SREBF2 PRKAA2 SP1 RBP4 AMFR INS CAMP PPARGC1B MVD HEL-S-32 MBTPS1 MITOCHONDRIAL FATTY ACID SYNTHESIS PATHWAY%WIKIPATHWAYS_20260610%WP4317%HOMO SAPIENS Mitochondrial fatty acid synthesis pathway ACACA OXSM HTD2 MCAT MECR HSD17B12 SERINE METABOLISM%WIKIPATHWAYS_20260610%WP4688%HOMO SAPIENS Serine metabolism DHFR SHMT1 HEL-S-51e PHGDH PSAT1 TYMS PSPH RENIN ANGIOTENSIN ALDOSTERONE SYSTEM RAAS %WIKIPATHWAYS_20260610%WP4756%HOMO SAPIENS Renin angiotensin aldosterone system RAAS CAMK2A ATF1 CREB1 CMA1 CTSG PLCB2 REN ITPR2 CAMK2D ATF2 HSD3B2 CYP11B2 CYP21A2 CREB3L3 HSD3B1 CAMK1 CALML6 CREB3L4 CYP11A1 CALML3 CREB3L2 STAR CALML4 CAMK2G ATF4 CAMK1D CAMK1G CREB3 CALM1 AGTR1 AGTR2 CREB5 ATF6B CAMK4 EGF EGFR SIGNALING%WIKIPATHWAYS_20260610%WP437%HOMO SAPIENS EGF EGFR signaling CAMK2A INPP5D PLSCR1 CREB1 RPS6KA5 ARF6 ARHGEF1 SH3GL2 GAB2 VAV1 CBL JUND MAP3K1 FOSB RPS6KB1 CBLC RPS6KA2 ITCH ATF1 RPS6KA1 CRKL MEF2D HEL-S-15 AP2A1 MAP2K1 MAP2K2 PCNA SHC1 NCK2 NCK1 HGS MEF2C RAF1 RAP1A EIF4EBP1 PLCE1 JUN PTPN5 SP1 CAV2 MAPK9 GRB2 MAPK7 MAPK4 RAB5A MAP3K2 PTEN HRAS JAK1 MAP4K1 RAC1 VAV2 FOS STXBP1 SH3GL3 SOS1 CRK CDC42 MAPK8 PAK1 NEDD4 MAPK1 PTK2B NEDD8 RICTOR IQGAP1 EGFR SYNJ1 STAT1 STAT3 PTPN11 NDUFA13 MAPK14 MTOR SPRY2 USP6NL GJA1 SOS2 INPPL1 AP2M1 RALBP1 STAMBP PXDN RIN1 STAM2 SH2D2A PLD2 ATXN2 STAT5B HEL-S-34 EPS15L1 EPN1 RALA ASAP1 AP2S1 REPS2 LIMK2 SRC PIK3C2B PRKCB PLCG1 PRKCI PDPK1 PRKCA PRKCZ TNK2 ERBB2 EGF MAP2K5 PTK6 PIK3R2 FOXO4 PIK3R1 FOXO1 GRB10 VAV3 ROCK1 COX2 RALB CSK CEREBRAL ORGANIC ACIDURIAS INCLUDING DISEASES%WIKIPATHWAYS_20260610%WP4519%HOMO SAPIENS Cerebral organic acidurias including diseases MDH2 D2HGDH ALDH7A1 GCDH ADHFE1 HEL-S-5 L2HGDH MULTIPLE EPIPHYSEAL DYSPLASIA AND PSEUDOACHONDROPLASIA GENES%WIKIPATHWAYS_20260610%WP4789%HOMO SAPIENS Multiple epiphyseal dysplasia and pseudoachondroplasia genes COL9A1 MATN1 COL9A3 COL9A2 MATN3 COMP INTEGRATIVE ANALYSIS OF TREG GLIAL INTERACTIONS %WIKIPATHWAYS_20260610%WP5561%HOMO SAPIENS Integrative Analysis of Treg Glial Interactions NKX6-1 MYD88 TGFBR2 CD44 CDC42 HTR7 CD68 OLIG2 IL1B CCR8 ITGA2 FOXP3 CXCL1 EGFR STAT1 TNF CTLA4 STAT3 CCR6 MBP MAPK14 IL10 IL12RB1 IL33 TYK2 IL2 STAT5B IL10RB SOX9 IL10RA PDCD1 PDGFRA SOCS3 JAK3 STAT4 IKZF2 MMP9 IGF1R CCN3 VEGFA NKX6-2 OLIG1 CNP EBI3 APOD KLRG1 SIRPA GSDMD MOG MCAM IL6 TMEM119 CXCL12 IGF1 FOXO4 TLR4 FOXO1 opn TGFBR1 NFKB1 NFKB2 CSPG4 FOXO3A FAM20C CD80 IL2RG TNFRSF1B ROS1 CD47 AREG CX3CR1 AIF1 SMAD2 IL2RA PDGFA IL2RB NOS2 NKX2-2 CCL1 IL12A CCL20 IL4 TGFB1 ITGB3 IL18 HEL-S-111 ITGAV SSTR2 JAK1 IFNG OSM RAC1 NLRP3 TGFBR3 NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN NOD PATHWAY%WIKIPATHWAYS_20260610%WP1433%HOMO SAPIENS Nucleotide binding oligomerization domain NOD pathway NOD1 NLRC4 DUOX2 MEFV NLRP7 NLRP2 NLRP1 AAMP IL1B PYCARD CARD8 CARD9 ERBIN CARD6 ACAP1 AIM2 NLRP10 NAIP IKBKB NDUFA13 IKBKG CHUK RELA CASP5 NFKBIA COPS6 NOD2 CASP9 IL18 CASP8 RIPK2 NLRP3 RAC1 NLRP12 NAD METABOLISM SIRTUINS AND AGING%WIKIPATHWAYS_20260610%WP3630%HOMO SAPIENS NAD metabolism sirtuins and aging FOXO1 NFKB1 TFAM FOXO3A PPARG SIRT1 HIF1A SIRT3 NAMPT ROS1 EXERCISE INDUCED CIRCADIAN REGULATION%WIKIPATHWAYS_20260610%WP410%HOMO SAPIENS Exercise induced circadian regulation CLDN5 CRY2 CRY1 HLA-DMA UCP3 CBX3 PIGF G0S2 HEL-S-72p CEBPB TOB1 SUMO1 DAZAP2 BTG1 NR1D2 PURA STBD1 SUMO3 QK3 ERC2 GSTM3 RBPMS ZFR HEL-S-22 PSMA4 AAG1 VAPA PPP1R3C MYF6 H2BC15 PER2 NCKAP1 ETV6 PER1 KLF9 APOPTOSIS REGULATION BY PARATHYROID HORMONE RELATED PROTEIN%WIKIPATHWAYS_20260610%WP3872%HOMO SAPIENS Apoptosis regulation by parathyroid hormone related protein ITGA6 BOK BAX BCL2L12 BCL2L10 BCL2L14 BCL2A1 MYC BCL2L13 BCL2 GSK3B PTHLH BAK1 ITGB4 BCL2L2 GSK3A BCL2L1 AKT3 MCL1 AGE RELATED MACULAR DEGENERATION%WIKIPATHWAYS_20260610%WP5526%HOMO SAPIENS Age related macular degeneration MTOR PMAIP1 PRKAA2 PRKAB2 PRKAB1 PRKAA1 RPTOR PPARGC1A MLST8 MAPK3 SIRT1 HEL-S-32 PARP2 PRKAG1 PRKAG2 PRKAG3 RPS6KB1 CONSTITUTIVE ANDROSTANE RECEPTOR PATHWAY%WIKIPATHWAYS_20260610%WP2875%HOMO SAPIENS Constitutive androstane receptor pathway UGT1A1 ABCC3 CYP3A4 NCOA1 NR1I3 ABCC2 ABCB1 CYP2C19 CYP2C9 CYP2A6 RXRA FOXO1 CYP2B6 DNAJC7 PPARGC1A SULT2A1 SMC1A ALAS1 UGT1A4 UGT1A3 UGT1A9 SP1 NCOA6 EHHADH PTPA SULT1A1 CYP4A11 ANDROGEN BIOSYNTHESIS%WIKIPATHWAYS_20260610%WP5393%HOMO SAPIENS Androgen biosynthesis AKR1C1 CYP3A7 AKR1C2 AKR1C4 CYP3A4 HSD17B3 POR HSD17B4 CYP17A1 HSD17B1 HSD17B2 HSD11B1 HSD11B2 SULT2A1 SRD5A2 HSD3B2 AKR1D1 HSD3B1 LEPTIN SIGNALING%WIKIPATHWAYS_20260610%WP2034%HOMO SAPIENS Leptin signaling SOS1 CDC42 NCOA1 CREB1 ARHA PRKAA1 MAPK8 CFL2 MAPK1 MAPK3 BAD STAT1 STAT3 IKBKB ACACB PTPN11 ACACA MAPK14 IKBKG MTOR CHUK IRS1 RELA STAT5B SOCS3 SRC FYN EIF4E RPS6KB1 PLCG1 REL RPS6KA1 ERBB2 PLCG2 MAP2K1 GSK3B MAP2K2 SHC1 PIK3R2 PIK3R1 FOXO1 NFKB1 SH2B1 LEP RPS6 RAF1 GSK3A LEPR EIF4EBP1 ROCK1 ROCK2 PRKAA2 SP1 PDE3B KPNA4 KHDRBS1 GRB2 SOCS7 PTPN1 PTEN HRAS CISH JAK1 RAC1 SOCS2 P53 TRANSCRIPTIONAL GENE NETWORK%WIKIPATHWAYS_20260610%WP4963%HOMO SAPIENS p53 transcriptional gene network DDIT4 NOTCH1 DEPTOR CX3CL1 PRKAA1 AKT1S1 TP53INP1 GPX1 TNF MTOR BAX XRCC5 SESN2 IRF9 CCL2 ISG15 XPC TIGAR NCF2 CCNG1 THBS1 TP53I3 PRKAB2 SLC7A11 ERCC5 PRKAB1 ULK2 PCNA BBC3 TP53AIP1 PIDD1 TSC2 AURKA SESN1 MSH2 MLST8 BTG2 APAF1 ULK1 DDB2 PRKAG1 PRKAG2 RRM2B PRKAG3 GLS2 E2F7 CCNE1 POLK PMAIP1 SFN GADD45A PRKAA2 TNFRSF10B PML CDK2 SMR3B ACAD11 CDKN1A CPT1C SERPINB5 PTEN TRAF4 SCO2 RPTOR ADGRB1 DRAM1 ZMAT3 ADORA2B PERP RPRM SIVA1 TNFSF6 FUCA1 TNFRSF10D LIF ULBP2 ULBP1 MIRNA ROLE IN IMMUNE RESPONSE IN SEPSIS%WIKIPATHWAYS_20260610%WP4329%HOMO SAPIENS miRNA role in immune response in sepsis ELANE REL MYD88 IRF-1 IL6 RELB VCAM1 MAPK8 TLR4 NFKB1 CXCL8 NFKB2 TNF IKBKB MAP3K7IP1 MAPK14 IKBKG CHUK IL10 IRAK4 TLR8 RELA TRAF3 NFKBIA TRAF6 IRF7 TLR7 MAP3K7 LCN2 CCL4 CCL3 IL1A IRAK1 PROGERIA ASSOCIATED LIPODYSTROPHY%WIKIPATHWAYS_20260610%WP5103%HOMO SAPIENS Progeria associated lipodystrophy KCNJ6 SMAD2 MUCL3 RECQL SPRTN INS LMNB2 ZMPSTE24 WRN TGFB1 LMNA FFAR3 SMAD4 PPARG FBN1 FNTA BANF1 ICMT ERK PATHWAY IN HUNTINGTON 39 S DISEASE%WIKIPATHWAYS_20260610%WP3853%HOMO SAPIENS ERK pathway in Huntington 39 s disease HTT EGF CREB1 RPS6KA5 MAP2K1 MAP2K2 MAPK1 MAPK3 BDNF CASP3 RAF1 EGFR HRAS NTRK2 KETOGENESIS AND KETOLYSIS%WIKIPATHWAYS_20260610%WP4742%HOMO SAPIENS Ketogenesis and ketolysis BDH1 OXCT1 ACAT1 UCP2 CPT2 SLC25A20 GROWTH FACTORS AND HORMONES IN BETA CELL PROLIFERATION%WIKIPATHWAYS_20260610%WP5385%HOMO SAPIENS Growth factors and hormones in beta cell proliferation PDGFA RAB43 RASSF1 CDK4 MYC INS CDK2 PDX1 CRTC2 IGF1 FOXM1 FOXO1 MAPK1 INSR TGFBR1 FLT1 MAPK3 IGF1R AKT3 TLR4 SIGNALING AND TOLERANCE%WIKIPATHWAYS_20260610%WP3851%HOMO SAPIENS TLR4 signaling and tolerance IFNB1 MYD88 IKBKE IL6 INPP5D TRAM1 TLR4 NFKB1 CXCL8 TNF IKBKB MAP3K7IP1 TBK1 IRAK3 IKBKG CHUK IRAK4 TICAM1 TIRAP IRF3 TRAF3 NFKBIA TRAF6 IRF7 MAP3K7 IRAK1 RIPK1 RANKL RANK SIGNALING%WIKIPATHWAYS_20260610%WP2018%HOMO SAPIENS RANKL RANK signaling TNFRSF11B PLCG1 NFATC1 FHL2 RELB CDC42 SQSTM1 MAP2K1 PIK3R2 MAPK8 PIK3R1 LYN MAPK1 NFKB1 NFKB2 MAPK3 SPI1 STAT1 TRAF1 IKBKB MAP3K7IP1 MAPK14 IKBKG MTOR JUN CHUK TRAF2 RELA MAPK9 TRAF3 NFKBIA TRAF6 GAB2 TRAF5 MAP3K7 SYK TNFRSF11A CBL PAPSS2 SRC MAP2K6 RAC1 TNFSF11 FOS MIR TARGETED GENES IN SQUAMOUS CELL%WIKIPATHWAYS_20260610%WP2006%HOMO SAPIENS miR targeted genes in squamous cell TUBA1A TGFBR2 DHX57 HOXA7 GOLGA7 GAS2L1 ATP6V1F SEC23A PEDS1-UBE2V1 PRPF40A MRPS33 YWHAQ TMEM59 VCAM1 HSD17B12 HES1 CTDSP1 DNAJB1 ELOVL5 E2F3 PDLIM7 SLC12A2 GALNT7 GALNT1 POLR2C POLD2 FMNL2 CUL4B BET1 AKAP8 HEL-S-30 SDCBP FBXW11 MAP3K8 AP2A1 NRP1 CPNE8 VEZT RHEB TNFRSF10B PWP1 CIAO2A ATP6V0E1 FNDC3B FNDC3A PISD GYS1 UBE2J1 MRPL20 COMMD9 HMOX1 ATP6V1C1 ANXA2 MOV10 SYNE2 SPTLC1 ANP32B RNP24 ARF4 AXL POM121 TRAM1 NEDD4 MAGT1 MRC2 TMEM43 PPP1R7 SH3BP4 TMED7 HMGA1 CSDE1 PXDN PTMA SMAD1 MPZL1 AP3D1 FGF2 ARCN1 SPCS3 HEL-S-26 THBS1 LAMTOR5 POGLUT3 SLC38A1 RARS1 LAMC1 NCL TPM3 SRSF9 TPM1 RAI14 TMED10 CBFB PNP ADIPOR2 RTN4 GFPT1 SLC4A10 TBCA P4HA2 CHMP2A SRPRB NF2 DKFZp761E1322 PICALM ATP2A2 ADAR IL6 SIGNALING%WIKIPATHWAYS_20260610%WP364%HOMO SAPIENS IL6 signaling MAP2K4 IRF-1 SOS1 IL6 VIP NCOA1 MAP2K1 GSK3B MAP2K2 NR2F6 SHC1 PIK3R2 PIK3R1 MAPK1 MAPK3 BAD STAT1 STAT3 CRP PTPN11 IL6ST IL6R TYK2 GRB2 VAV1 MAP3K7 JUNB SOCS3 CREBBP NLK JAK1 HDAC1 RAC1 BCL2L1 TIMP1 RPS6KB1 AXON GUIDANCE%WIKIPATHWAYS_20260610%WP5289%HOMO SAPIENS Axon guidance RHOD CDC42 HEL-S-28 ITGB1 ROBO2 RYK SEMA5B ROBO3 DPYSL5 BOC MAPK1 DCC CXCR4 UNC5D SEMA7A PARD3 EFNB1 PARD6A ABLIM3 LRIG2 SRGAP2 EFNA1 TRPC1 NTNG2 PTCH1 L1CAM FES GNAI1 RRAS NGL1 SRC FYN MYL12B PDPK1 PRKCA PRKCZ NTN3 ARHGEF12 CXCL12 HEL-S-15 GSK3B NCK1 ROBO1 RAF1 WNT4 NRP1 FZD3 RGMA BMPR2 ROCK1 SLIT1 EPHA2 SLIT3 SLIT2 SHH CDK5 gdf7 EPHB1 HRAS SEMA3A PLXNA1 RAC1 OXIDATIVE STRESS RESPONSE%WIKIPATHWAYS_20260610%WP408%HOMO SAPIENS Oxidative stress response MAPK10 HMOX1 NQO1 CYP1A1 GCLC TXN2 CYBB HEL-S-44 NFE2L2 NFKB1 NOX4 GPX1 GPX3 GSTT2 MAPK14 NOX3 UGT1A3 NOX5 XDH SP1 MGST1 MAOA JUNB HEL-75 TXNRD2 FOS PROXIMAL TUBULE TRANSPORT%WIKIPATHWAYS_20260610%WP4917%HOMO SAPIENS Proximal tubule transport SLC5A5 ATP6V1C1 AQP1 ATP6V1F ABCC2 ABCB1 SLC34A3 SLC34A1 SLC9A3 SLC16A10 ABCG2 SLC2A2 SLC47A2 ATP6V1A SLC22A6 SLC47A1 SLC22A2 SLC3A1 SLC5A1 SLC5A2 SLC7A7 SLC6A20 SLC4A4 CLTRN CA4 ATP6V0A4 SLC3A2 ATP1A1 ATP6V1E1 ATP6V1D SLC22A11 ATP6V0B ATP6V0E1 SLC6A18 SLC36A2 ATP1B1 SLC1A1 HEL-76 SLC5A8 SLC6A19 SLC7A9 FXYD2 ATP6V0D2 ATP6V0C SLC22A7 ATP6V1G1 ATP6V1B1 METHIONINE METABOLISM LEADING TO SULFUR AMINO ACIDS AND RELATED DISORDERS%WIKIPATHWAYS_20260610%WP4292%HOMO SAPIENS Methionine metabolism leading to sulfur amino acids and related disorders CDO1 pcap CTH MTR CBS HEL-S-61p MAT1A ADK HEL-S-182mP NO CGMP PKG MEDIATED NEUROPROTECTION%WIKIPATHWAYS_20260610%WP4008%HOMO SAPIENS NO cGMP PKG mediated neuroprotection GUCY1B1 CAMK2A GRIN2B CNGA3 CNGA4 PBR DLG4 GUCY1A2 PDE2A CNGB3 NEFL CREB1 PDE3A IL1B NFKB1 CAMK2D CNGA1 BAD TNF ACTN2 CAMK2G NOS2 AKAP9 BCL2 RELA NFKBIA CALM1 CNGB1 CYCS GRIN1 NPPB CASP9 NPPA IFNG NITRIC OXIDE METABOLISM IN CYSTIC FIBROSIS%WIKIPATHWAYS_20260610%WP4947%HOMO SAPIENS Nitric oxide metabolism in cystic fibrosis NOS2 PRMT6 HEL-S-277 PRMT7 PRMT2 PRMT3 CARM1 PRMT1 BMP2 WNT4 FOXO1 PATHWAY IN PRIMARY ENDOMETRIAL STROMAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260610%WP3876%HOMO SAPIENS BMP2 WNT4 FOXO1 pathway in primary endometrial stromal cell differentiation FOXO1 DCN SMAD1 SMAD9 SST BCL2L11 DKK1 WNT4 DKFZp781O1323 SFRP1 BMP2 LEFTY2 DIET DEPENDENT TRIMETHYLAMINE TRIMETHYLAMINE N OXIDE METABOLISM %WIKIPATHWAYS_20260610%WP5219%HOMO SAPIENS Diet dependent trimethylamine trimethylamine N oxide metabolism ALDH7A1 SLC44A1 CHDH TRANSCRIPTIONAL CASCADE REGULATING ADIPOGENESIS%WIKIPATHWAYS_20260610%WP4211%HOMO SAPIENS Transcriptional cascade regulating adipogenesis KLF15 CEBPG CEBPB CEBPD GATA3 DDIT3 KLF2 CEBPA KLF5 PPARG EGR2 GATA2 COMMON PATHWAYS UNDERLYING DRUG ADDICTION%WIKIPATHWAYS_20260610%WP2636%HOMO SAPIENS Common pathways underlying drug addiction CAMK2A PRKCB PRKCA CREB1 MAP2K1 GJB1 DRD2 PPP1R1A GNAS MAP2K2 MAPK1 DRD1 MAPK3 RAF1 ARAF GNAI1 RAP1A ACTG2 PRKACG ADCY1 ADCY8 ACTG1 PPP1CC PS1TP5BP1 CALM1 HEL-S-80p GRIN1 CAMK4 GRIA2 DRD4 GRIA3 GRIA4 MIR 517 RELATIONSHIP WITH ARCN1 AND USP1%WIKIPATHWAYS_20260610%WP3596%HOMO SAPIENS miR 517 relationship with ARCN1 and USP1 CDKN1A USP1 ID1 ARCN1 GIG8 ESTROGEN SIGNALING%WIKIPATHWAYS_20260610%WP712%HOMO SAPIENS Estrogen signaling MAPK14 GNB1 IKBKG JUN CHUK PIK3CA SP1 CREB1 MAP2K1 BCL2 MAPK9 GNAS GPER MAPK1 NFKB1 GNGT1 IKBKB FOS DNA DAMAGE RESPONSE ONLY ATM DEPENDENT %WIKIPATHWAYS_20260610%WP710%HOMO SAPIENS DNA damage response only ATM dependent MAPK10 PIK3CA SOS1 CDC42 ARHA MAPK8 MAPK1 BAD APC DVL3 CDKN2A AKT3 BAX HMGB1 SOS2 BCL2L11 IRS1 PPP2R5E LDLR PIK3CD LEF1 PPP2R5C WNT3A RBL2 TCF7L2 TCF7L1 BCL6 SMAD4 PIK3C2G MAP3K1 FOSL1 PIK3C2B PIK3R4 CCND1 ERBB2 MYC GSK3B WNT2B PIK3R3 MLKL BBC3 SHC1 PIK3R2 BIK WNT5B CCNG2 PIK3R1 CCND3 G6PC1 CCND2 WNT16 NRAS AXIN1 INSR NFKB1 NFKB2 RAC3 FOXO3A WNT3 WNT4 DVL2 WNT10B PCK2 WNT10A WNT7B WNT7A JUN PMAIP1 FRAT1 BCL2 MAPK9 MDM2 GRB2 TGFB1 ATM BAK1 TP73 CDKN1A CDKN1B MAP3K7 PIK3R5 PTEN HRAS TNFSF6 DVL1 WNT1 RAC1 TRYPTOPHAN CATABOLISM LEADING TO NAD PRODUCTION%WIKIPATHWAYS_20260610%WP4210%HOMO SAPIENS Tryptophan catabolism leading to NAD production NMNAT3 NAPRT HAAO NMNAT1 TDO2 NMNAT2 AFMID NAMPT KYNU NMRK2 NMRK1 KMO NADSYN1 AADAT HEL-S-90n IDO1 CELL DIFFERENTIATION EXPANDED INDEX%WIKIPATHWAYS_20260610%WP2023%HOMO SAPIENS Cell differentiation expanded index HDAC5 MEF2B MEF2D KLF4 TLX3 SOX2 MYOD1 GIG8 TLX2 LEFTY1 PAX7 TLX1 MEF2C RUNX2 STAT3 LEFTY2 EZH2 TNF RELATED WEAK INDUCER OF APOPTOSIS TWEAK SIGNALING%WIKIPATHWAYS_20260610%WP2036%HOMO SAPIENS TNF related weak inducer of apoptosis TWEAK signaling RELB GSK3B MAPK8 NFKBIB MAPK1 NFKB1 NFKB2 MAPK3 TNFRSF12A MAP3K14 RAF1 TRAF1 TNF IKBKB BIRC2 MAPK14 BIRC3 JUN CHUK TRIM63 TRAF2 RELA MAPK9 TRAF3 NFKBIA TRAF5 MAP3K7 CASP8 CASP3 HDAC1 RIPK1 FADD TNFSF12 RAC1 CANCER IMMUNOTHERAPY BY CTLA4 BLOCKADE%WIKIPATHWAYS_20260610%WP4582%HOMO SAPIENS Cancer immunotherapy by CTLA4 blockade PIK3R2 PTPN11 PPP2CA PTPN6 PIK3R1 HLA-DRB1 PIK3CA PIK3CD CD80 CTLA4 PIK3R3 SEROTONIN HTR1 GROUP AND FOS PATHWAY%WIKIPATHWAYS_20260610%WP722%HOMO SAPIENS Serotonin HTR1 group and FOS pathway PDPK1 HTR1A PIK3CA HTR2A CREB1 RPS6KA5 MAP2K1 MAPKAPK2 MAP2K2 ARHA RASGRF1 MAPK1 MAPK3 HTR1E HTR1F GNAO1 HTR1D HTR1B STAT3 GNAI1 RAP1A MAPK14 MAP2K3 GNAI3 MAP2K6 MAPKAPK3 MAP3K1 FOS METABOLISM OF ALPHA LINOLENIC ACID%WIKIPATHWAYS_20260610%WP4586%HOMO SAPIENS Metabolism of alpha linolenic acid ALOX15 ALOX12 FADS1 ALOX5 FADS2 PTGS2 DYRK1A INVOLVEMENT REGARDING CELL PROLIFERATION IN BRAIN DEVELOPMENT%WIKIPATHWAYS_20260610%WP5180%HOMO SAPIENS DYRK1A involvement regarding cell proliferation in brain development DCAF7 HES5 DNER NOTCH1 REST CREB1 DEPTOR CSNK1A1 HES1 AKT1S1 RBBP4 MTOR SPRY2 RBL2 H3F3B FGF2 SIRT1 CRY2 NFATC1 PSENEN BACE1 APP CCND1 TFDP1 PSEN1 TFDP2 GSK3B TSC2 LIN9 TSC1 LATS2 FOXO1 MLST8 LIN54 GMNN LIN52 TFDP3 AMPH LIN37 TFAP4 NEUROG2 E2F5 CDK4 CDK6 RBL1 CDKN1B RPTOR E2F4 CASP9 CASP3 DYRK1A EIF2B5 HDAC6 INTERACTIONS IN THE CENTRAL NERVOUS SYSTEM%WIKIPATHWAYS_20260610%WP5426%HOMO SAPIENS HDAC6 interactions in the central nervous system TUBA1C KAT5 MYD88 ADRBK1 HTT NR3C1 TUBB CFTR HEL-S-2a DCTN1 SIRT2 TUBA4A SNCA PARK2 MAPK8 TUBA2 MAPK1 FOXP3 PTK2B MAPK3 EGFR APC EP300 BAX BBIP1 VCP VHL GRIA2 APOE HIF1A ISG15 CDC20 DLG4 PRKCZ MAP3K5 MAP1B SQSTM1 GSK3B CYBB HEL-S-44 HEL-S-72p BIRC5 AURKA TWIST1 ERG GSK3A OPTN PXN SMAD2 HDAC11 PRKCE IKBKAP RHOT1 CD133 FAT10 MYH9 MAPRE1 SHH ITIH4 SP1 NEDD9 KALRN HEL-S-67p BCL2 ATXN3 HSF1 EP400 CCDC141 HSPA4 FUS FREP1 MIIP ELP3 HEL-S-102 ARID3A SGK1 SNCAIP CSNK2A2 GARS1 CNOT6 BDNF DLG2 STUB1 POU5F1 TARDBP MAP1LC3A HEL-S-32 CSNK2B HEL113 RAC1 HYPOTHETICAL CRANIOFACIAL DEVELOPMENT PATHWAY%WIKIPATHWAYS_20260610%WP3655%HOMO SAPIENS Hypothetical craniofacial development pathway ARHGEF2 TP63 IRF6 ARHGAP29 TFAP2A ARHA CALCIUM REGULATION IN CARDIAC CELLS%WIKIPATHWAYS_20260610%WP536%HOMO SAPIENS Calcium regulation in cardiac cells CAMK2A PLCB3 HEL-S-93 PRKAR1B HEL2 PRKAR1A GJA5 GNAS YWHAQ ATP2B1 HEL-S-1 YWHAG CAMK2D DKFZp686L0365 GJB2 GNGT1 PRKD1 GNAZ GNAI3 PLN CACNB1 CACNB3 HEL-S-99n GNG3 ATP1B1 CACNA1B GNG5 CACNA1A GNG4 FKBP1A GNG7 FXYD2 GNG8 KCNJ3 GNG12 GNG11 GNG13 GJB6 GNB2 CACNA1S GNB1 GNB5 GJB1 CAMK1 PRKCE SFN GNA11 CALM1 GJA3 GJA4 GJA9 GJA8 ATP1B3 ATP1B2 STIM2 CHRM1 GJC1 GJC2 RGS16 GJB4 GJB3 GJB5 ANXA6 GJD2 ADRB3 CASQ2 CASQ1 ATP1A4 KCNJ5 KCNB1 ATP2B3 ATP2B2 RYR1 GNAO1 RYR2 RYR3 GNAI1 GNB4 GJA1 ADCY3 ADRA1D ADRB1 ADCY1 ADRB2 ADCY8 ADCY6 ADCY5 ADCY9 GNG2 PRKCB PRKCH PRKCA PRKCQ PRKCZ ADRA1A CHRM2 SLC8A1 RGS4 RGS5 RGS2 RGS1 RGS6 ITPR2 GRK5 GRK4 PKIB PKIA PKIG ORAI1 CACNA1C RGS18 RGS17 RGS20 CAMK2G RGS10 RGS11 ADRA1B GNB3 CHRM3 CHRM4 CHRM5 CAMK4 ATP2A2 RGS14 ATM SIGNALING%WIKIPATHWAYS_20260610%WP2516%HOMO SAPIENS ATM signaling CASP2 CHEK2 CREB1 CHEK1 H2AX CRADD PIDD1 TLK1 ATF2 NBN MDC1 SMC1A MRE11A CCNE1 IKBKG CCNB1 JUN RAD50 CDC2 GADD45A CDK2 MAPK9 MDM2 RAD51 TP53BP1 ATM TP73 CDKN1A RAD9A BRCA1 RIPK1 DKFZp781B1423 SOMATROPH AXIS GH AND ITS RELATIONSHIP TO DIETARY RESTRICTION AND AGING%WIKIPATHWAYS_20260610%WP4186%HOMO SAPIENS Somatroph axis GH and its relationship to dietary restriction and aging MTOR FOXO1 PTEN SIRT1 IGF1R CYTOSINE METHYLATION%WIKIPATHWAYS_20260610%WP3585%HOMO SAPIENS Cytosine methylation MBD3 TDG TET2 HEL-S-26 TET1 PHOSPHODIESTERASES IN NEURONAL FUNCTION%WIKIPATHWAYS_20260610%WP4222%HOMO SAPIENS Phosphodiesterases in neuronal function GUCY1B1 CAMK2A GRIN2B PDE7B GUCY1A2 PDE7A PDE2A CREB1 PDE3A DRD2 PDE11A PDE6C DRD1 PDE6A PDE6H PDE6G PDE10A CHRNA7 PDE12 PDE9A PDE4B PDE4A PDE8A PDE5A PDE4D ADCY3 ADCY1 PDE1C PDE1B PDE3B ADCY8 PDE1A ADCY6 ADCY5 HEL-S-7a ADCY9 GRIN1 PPP1R1B ADORA2A PRKG1 PDE6D FANCONI ANEMIA%WIKIPATHWAYS_20260610%WP5465%HOMO SAPIENS Fanconi anemia SLX4 ERCC1 UHRF1 CEBPD NBN FANCG EGFR DCLRE1B CTDP1 UHRF2 MRE11A FANCD2 FAAP24 MEN1 FANCM CENPX RAD50 FANCL REV1 SMARCA4 FANCB FANCE FANCF MAD2L2 RAD51C BRIP1 UBE2T FAN1 CENPS RAD51 ATM ATR USP1 FANCA MCM2 PTEN PALB2 BRCA1 RFWD3 HEL-S-125m BRCA2 MITOCHONDRIAL COMPLEX II ASSEMBLY%WIKIPATHWAYS_20260610%WP4920%HOMO SAPIENS Mitochondrial complex II assembly SDHAF1 SDHD SDHAF4 SDHA SDHB SDHAF2 SDHAF3 SDHC PARKINSON 39 S DISEASE PATHWAY%WIKIPATHWAYS_20260610%WP2371%HOMO SAPIENS Parkinson 39 s disease pathway UBB PINK1 CASP2 LRRK2 DDC SLC6A3 SNCA HEL-117 PARK2 TH HTRA2 APAF1 SEPT5 CCNE2 UBE2L6 CCNE1 MAPK14 HEL-S-67p CASP6 ATXN2 CYCS UBA7 UBE2J2 UBE2L3 GPR37 UBE2G1 SNCAIP MAPK12 CASP9 UBE2G2 MAPK13 MAPK11 EPRS1 CASP3 SYT11 UBE2J1 ENDODERM DIFFERENTIATION%WIKIPATHWAYS_20260610%WP2853%HOMO SAPIENS Endoderm differentiation NOTCH1 BMPR1A NR3C1 PTHLH NOG CAND1 LRPPRC APC ATP8B2 ACACA CUL4B CRTC1 MAP2K3 PIAS1 SMAD4 NLK AEBP2 DNMT3B EZH2 FOXA1 APP NKX2-1 DUSP4 DUSP2 SESN1 SMAD2 PLCH1 SOX17 CER1 DKK1 C1QBP SFRP1 BPTF GDF3 NODAL ELAVL1 WWC1 CTBP2 OTX2 TBX21 SOX21 PAX3 CEP250 WDHD1 FOXH1 STAT1 EMSY TCF4 WDFY2 BCORL1 TOX GATA6 MBTD1 EPB41L5 UBR5 PBX3 ZFHX4 MAD2L2 NABP2 TRIM71 EXT1 BCAR2 LEF1 PHF6 ZIC3 TRIM5 TCF7L1 JARID2 SLC2A12 TET1 PARP8 HOXA1 TOX3 SFMBT1 CDYL RFX7 AHDC1 FOXA2 RAB38 CTR9 PRDM14 ZNF462 RTF1 ELP4 SIAH2 ZIC5 FOXN3 SP4 LHX1 PAF1 TAF4B TCF2 ONECUT1 HOXC11 CDC73 SOX2 HHEX DUSP5 GATA4 Pax9 PABPC1 BTAF1 SOX7 TCEAL2 LEO1 FOXO1 KDM4A TNRC6C LAMC1 WNT8A CEBPZ TAF5 WNT3 VAV3 PBX1 RGS10 TGFB1 BMP7 NR1B3 MIXL1 POU5F1 PPAR SIGNALING%WIKIPATHWAYS_20260610%WP3942%HOMO SAPIENS PPAR signaling UCP1 UBC PDPK1 ACOX1 FADS2 HEL-S-28 CYP8B1 SLC27A5 CYP27A1 LPL RXRA PCK1 HEL-S-104 AQP7 DBI OLR1 FABP1 PPARG ANGPTL4 PCK2 ACSL1 NR1C2 CD36 SLC27A4 SCD RXRB RXRG CYP7A1 PLTP CPT2 APOA2 APOC3 EHHADH APOA5 SLC27A1 CPT1C PLIN1 NR1H3 CYP4A11 NR1C1 ME1 INTEGRIN MEDIATED CELL ADHESION%WIKIPATHWAYS_20260610%WP185%HOMO SAPIENS Integrin mediated cell adhesion MAPK10 ITGA6 ITGAX RAPGEF1 ITGA1 SOS1 CRK DOCK1 CDC42 HEL-S-28 ITGB1 RHO ITGA4 ITGA2 PAK1 ITGB7 MAPK1 ITGAM ARAF AKT3 MYLK2 ITGA2B HEL114 SELENOP MAP2K3 CAPN10 ARHGEF7 SRC FYN TLN1 MAP2K6 PDPK1 VASP MAP2K5 MAP2K1 MAP2K2 SHC3 SHC1 PIK3R2 ITGB4 ITGB8 RAC3 ITGB6 RAF1 ITGAE VAV3 MYPN CAPN9 CAPN6 PXN CAPN7 ITGA7 CAPN5 RAP1A TNS1 GIT2 CAPN11 ROCK1 ROCK2 CAV3 CAV2 CAPN3 PAK6 PAK4 MAPK7 GRB2 MAPK6 MAPK4 ZYX MAPK12 ITGB3 ITGAV HRAS CSK RAC1 VAV2 FGFR4 P G388R SIGNALING%WIKIPATHWAYS_20260610%WP5428%HOMO SAPIENS FGFR4 p G388R signaling IL10 STAT3 FGFR4 OXIDATION BY CYTOCHROME P450%WIKIPATHWAYS_20260610%WP43%HOMO SAPIENS Oxidation by cytochrome P450 CYP46A1 CYP2C19 CYP17A1 CYP4F12 CYP2C9 CYP27A1 CYP2R1 CYP2A6 CYP2B6 CYP3A43 CYP26C1 CYP11A1 CYP51A1 CYP4F3 CYP1A2 CYP1A1 CYP1B1 CYP3A4 CYP8B1 CYP2E1 CYP27B1 CYP24A1 CYP11B2 CYP2S1 CYP26B1 CYP4Z1 CYP3A7 CYP4V2 CYP7B1 CYP2A7 CYP2U1 CYP4F22 CYP26A1 CYB5R1 CYP7A1 CYB5R4 POR CYP4X1 CYB5R3 CYP2F1 CYB5B CYP2J2 CYP4F11 CYP4F8 CYP2W1 CYP27C1 CYP20A1 CYP4F2 CYP4A22 CYP2C18 CYP4A11 CYP2A13 IL17 SIGNALING%WIKIPATHWAYS_20260610%WP2112%HOMO SAPIENS IL17 signaling PIK3CA GSK3B NFKBIB CEBPB CEBPD MAPK1 NFKB1 MAPK3 MAP3K14 IL17RC IL17RB STAT3 IL17RA IKBKB IKBKG SP1 IL25 RELA TRAF3 TRAF6 IL17F IL17D IL17C MAP3K7 IL17B TRAF3IP2 IL17A JAK1 CELL CYCLE%WIKIPATHWAYS_20260610%WP179%HOMO SAPIENS Cell cycle CDK7 CDKN2D HEL-S-93 HEL2 CDKN1C YWHAQ HEL-S-1 YWHAG WEE1 E2F3 ANAPC1 EP300 HDAC2 SMAD4 SKP1 ORC1L RB1 SKP2 CCND1 CHEK2 MYC CHEK1 TFDP1 TFDP2 PCNA TTK CDC45 CCND3 E2F2 CCND2 CDC25B CDC23 SMC1A PRKDC CCNE2 CCNE1 PTTG1 CDC27 CCNB3 CCNB2 SMAD2 CCNB1 ANAPC7 PLK1 SFN CDC2 SMC1B GADD45B GADD45A STAG2 CDK4 ESPL1 ANAPC5 GADD45G CDK2 ANAPC2 CDK6 MDM2 ANAPC10 ANAPC11 ATM FZR1 ATR CDKN1A CDKN1B SMC3 RAD21 CDKN2B MAD1L1 CDKN2A CCNA2 MAD2L2 RBL2 CCNH MCM7 CDC20 STAG1 CDC6 RBX1 CDKN2C GSK3B E2F5 MCM3 MCM5 MCM6 TGFB1 RBL1 MCM2 CDC14B E2F4 PTTG2 ANAPC13 PKMYT1 ORC6 ORC3 ORC2 HDAC1 DBF4 WEE2 MIR TARGETED GENES IN LYMPHOCYTES%WIKIPATHWAYS_20260610%WP2004%HOMO SAPIENS miR targeted genes in lymphocytes TUBA1A DHX57 GOLGA7 GAS2L1 ATP6V1F PEDS1-UBE2V1 PRPF40A MRPS33 TMEM59 VCAM1 ITGA2 PRIM1 TYMS POLR2C POLD2 EHMT1 AKAP8 POLE4 POLA2 NARS1 RAB23 DNMT3B EZH2 MCL1 PPP5C PPP3R1 MAP3K8 BACE1 CXCL12 LPL VPS39 NRP1 TCL1A RAB5C CAP1 SNAP23 CPNE8 VEZT MTRR TMEM41B MTX1 CLDN1 BACH1 PWP1 CHORDC1 RAVER2 MAPK7 CIAO2A SEC62 CDK5RAP3 MBNL1 ATP6V0E1 HEL-S-303 CACNA2D1 IFRD1 MAPK12 FNDC3B FNDC3A C1QBP PISD CARHSP1 GYS1 WDR82 FAR1 RHOB HACD3 UBE2J1 DCAF7 MRPL20 COMMD9 RDH10 GRPEL2 HMOX1 ATP6V1C1 SNX6 ANXA2 GSTM4 RAB27B MOV10 NCEH1 PDE3A SFXN1 STRN ANP32B RNP24 ARF4 AXL DDX5 POM121 TRAM1 NEDD4 GFM1 ASH2L MAGT1 PTPRF MRC2 PANX1 COIL SERP1 IQGAP3 TMEM43 EGFR TMED3 DHX15 PPP1R7 GNPNAT1 NELFCD SH3BP4 TMED7 CTSC MRPS24 LAMTOR3 ELMOD2 TMT1A AP3B1 SLC7A6 CDCP1 CSDE1 FRG1 PXDN PTMA AMIGO2 PPP2R5C NAPG PTPA NT5E PGRMC1 USP1 SHOC2 SRSF10 COL4A2 MPZL1 SPRYD4 AP3D1 TTC9C ARHG ARCN1 WDR11 SPCS3 DOCK5 TPPP3 GPAM NFIA SNX15 SLC25A22 PKN2 LAMTOR5 TUSC2 TNLG5A LTN1 PPP3CA CPOX ARID4B TXN2 FADS2 ABHD10 POGLUT3 KPNA3 MYLIP TNFRSF10A SLC38A1 RARS1 ATG9A SNAP29 STX7 UBE4A LAMC2 CDKAL1 LAMC1 HEL-S-66 KCNN4 RAB30 SYPL1 GPD2 NCL PPIF GEMIN7 PPIB ABCG2 SRSF9 RAI14 NOTCH2 TMED10 CBFB SLC1A4 ADIPOR2 RTN4 CORO1C CD164 BRPF3 GFPT1 SLC4A10 TBCA IGF2R GNL3L P4HA2 CHMP2A SRPRB NF2 DKFZp761E1322 PICALM SLC25A1 CALCOCO2 DOCK7 TNFAIP2 ATP2A2 SSNA1 ADAR CYR61 SERPINE2 SYNE1 RRP8 TMEM109 LOC541469 ACP2 HOXA5 SCYL1 OTULINL HSDL1 HEL-S-47e FXR2 NOTCH1 TGFBR2 CEP72 RCN2 VTI1B RFT1 HARS1 RBMS1 BRI3BP FERMT2 CDKN1C SLC25A13 HOXD8 SEC23A RCOR1 LUZP1 MEOX2 NUFIP2 PTRH1 NXN VAMP3 PTBP1 YWHAQ UHRF1 TAF9B HSD17B12 TRMT1 ATAT1 GNA13 TRIP13 DNAJB1 LY6K CAND1 PHC2 GEMIN2 TDG ELOVL5 MSI2 TP53INP1 ARID2 FADS1 IGF2BP1 NPR3 E2F3 SAC3D1 ZNF622 MENT CDIPT ADPGK PDLIM7 UTP15 SLC25A24 MARS2 SLC12A2 RBM19 GALNT7 ANAPC1 UNC93B1 NHERF2 PLAG1 GALNT1 MRM1 CYP51A1 ABHD11 ABCF2 SLC4A7 RQCD1 MYO1E FMNL2 SLC25A32 CUL4B BET1 IRS1 MTHFD2 BCL6 HEL-S-30 EIF4E SDCBP FBXW11 ATG3 RB1 CCND1 AP2A1 PSAT1 SUCLG2 SMC1A AURKB PLK1 RHEB TNFRSF10B BCL2 CDK6 CDKN1A CDKN1B UBE2S BDNF NT5C3A ARID1A MYB CHAF1A SYNE2 PLXND1 SPTLC1 CDKN2A HMGA1 MAPK14 TERT KIT SMAD1 CSNK1D FGF2 PRKCI HEL-S-26 CYP1B1 CEBPB HEL-S-273 MPDU1 PURA HEL-S-108 TRPV6 TPM3 TPM1 PNP LMNB2 ARL10 GIP AND GLP 1 FUNCTION BY TISSUE%WIKIPATHWAYS_20260610%WP5509%HOMO SAPIENS GIP and GLP 1 function by tissue GCG GIP ALTERED GLYCOSYLATION OF MUC1 IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260610%WP4480%HOMO SAPIENS Altered glycosylation of MUC1 in tumor microenvironment IKBKG MUC1 CHUK NFKB1 IL6 TNF RELA IKBKB NFKBIA AMP ACTIVATED PROTEIN KINASE SIGNALING%WIKIPATHWAYS_20260610%WP1403%HOMO SAPIENS AMP activated protein kinase signaling PIK3CA ELAVL1 PLCB1 CAB39 STK11 PRKAA1 STRADB ADIPOR1 ACACB PRKACG ACACA MTOR LIPE STRADA CCNA2 HMGCR INS-IGF2 FASN SLC2A4RG PIK3CD HNF4A RPS6KB2 RPS6KB1 ADRA1A EEF2K PRKAB2 PRKAB1 EEF2 CRTC2 PIK3R3 PIK3R2 CPT1A TSC2 PIK3R1 TSC1 CAMKK1 CAMKK2 INSR SLC2A4 LEP PRKAG1 PRKAG2 PRKAG3 LEPR EIF4EBP1 CCNB1 ADIPOR2 PRKAA2 ADRA1B CDKN1A CPT1C GYS2 RPTOR PPARGC1B GYS1 HAIR FOLLICLE DEVELOPMENT CYTODIFFERENTIATION STAGE 3 OF 3%WIKIPATHWAYS_20260610%WP2840%HOMO SAPIENS Hair follicle development cytodifferentiation stage 3 of 3 ELANE CD34 RBPJ NOTCH1 BMPR1A NR3C1 FOXE1 WIF1 EGFR TCF4 GATA3 HR Nbla10317 HOXC12 KRTAP3-3 PHLDA1 EGR2 MSX2 LEF1 KRTAP15-1 SPINK6 CTGF SPINK5 ATL1-beta ADAMTS20 DSG1 SOX9 TP63 GAS1 DSG4 DSC2 SMAD1 ZBTB16 GPR49 DLX3 KLK5 KLK4 SMAD4 LRIG1 KRTAP6-1 KRTAP2-4 GSDMA GTPBP4 KLK13 FOSB FOXQ1 KLK14 FOXN1 GJB6 KRT19 MSX1 NFATC1 GPRC5D SOX2 IGF1 S100A4 BMP6 RUNX3 KLK6 NFKB1 DKK3 KRTAP8-1 ADAM17 NOTCH2 JUN CD133 IGFBP5 CD200 CASP14 SOSTDC1 TCF3 FST DKK1 PERP BMP4 DKK4 SFRP1 IFNG FZD1 FOS KITLG BDNF SIGNALING IN NEURODEVELOPMENT%WIKIPATHWAYS_20260610%WP5541%HOMO SAPIENS BDNF signaling in neurodevelopment HEL-S-47e HEL-S-93 HEL2 CREB1 MAPKAPK2 YWHAQ HEL-S-1 YWHAG TRADD PARD6A BCL2L11 IRS1 PIK3CD TRAF6 EIF4E FADD MAP3K1 RPS6KB1 NPTX2 SMPD1 FRS2 MAP3K5 MYC HEL-S-15 MAP2K1 EEF2 MAP2K2 SHC1 SH2B2 RAF1 APAF1 LINGO1 SORT1 NTRK2 KIDINS220 TIAM1 EIF4EBP1 PRKCE JUN BCL2 NFKBIA GRB2 MAPK7 CYCS CASP9 NGFR CASP8 MAPK11 BDNF HRAS RAC1 PIK3CA RAPGEF1 SOS1 CRK CDC42 ARHA MAPK8 PAK1 CFL2 MAPK1 MAPK3 PARD3 IQGAP3 BAD STAT3 IKBKB PTPN11 IKBKG MTOR CHUK BAX ARHGAP35 LEF1 PARD6B TCF7L2 TCF7L1 LIMK1 RPS6KB2 MAP2K4 PRKCB PLCG1 PRKCI WASL PRKCH PDPK1 PRKCA PRKCZ MAP2K5 EEF2K GSK3B RTN4R NRAS FOXO3A ROCK1 ROCK2 TP73 BMP7 DOCK7 FIBRIN COMPLEMENT RECEPTOR 3 SIGNALING%WIKIPATHWAYS_20260610%WP4136%HOMO SAPIENS Fibrin complement receptor 3 signaling IFNB1 TYROBP REL MYD88 PIK3CA FCER1G IL6 PLAT LBP ARHA FGA TLR4 NFKB1 PLG ITGAM HEL-S-78p CXCL3 TNF IKBKB IRAK2 IKBKG CHUK NOS2 TICAM2 IRAK4 TICAM1 TIRAP IL12B IRF3 RELA TLR3 CD14 TRAF6 SYK SRC IRAK1 CCL2 LY96 NF KB SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260610%WP5527%HOMO SAPIENS NF kB signaling and ARTD family members SKP1 ZC3HAV1 MAVS TIPARP RELB PARP16 RBX1 PARP12 PARP10 RIGI GSK3B TFPI2 NFKB2 MAP3K14 CLDN6 ERN1 IKBKB TBK1 IKBKG CHUK EP300 NFKBIA BTRC CREBBP PARP14 WNT BETA CATENIN SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260610%WP5529%HOMO SAPIENS Wnt Beta catenin signaling and ARTD family members SKP1 PLK1 BTRC AXIN1 RBX1 TNK2 PARP10 TNK1 APC DVL2 DVL1 DVL3 SIGNALING LIPIDS%WIKIPATHWAYS_20260610%WP5584%HOMO SAPIENS Signaling lipids ALOX15 EPHX2 ALOX12 PRXL2B CYP7B1 PTGES COX1 CYP7A1 PLA1A CYP8B1 FADS2 PLCB1 CYP2C9 CYP27A1 CYP2B6 CYP4F2 PLA2G1B GPX4 ALOX5 LTC4S PTGS2 HPGD NRF2 PATHWAY%WIKIPATHWAYS_20260610%WP2884%HOMO SAPIENS NRF2 pathway SLC5A5 TGFBR2 EGR1 TXN DNAJB1 GPX2 GPX3 GSTT2 AGER SLC5A1 SLC5A2 SLC6A20 SLC6A13 SLC6A11 SLC6A18 SERPINA1 SLC5A8 GCLM SQSTM1 SLC39A9 FTH1 SLC7A11 SLC39A6 SLC39A5 TGFA SLC39A8 GSTM2 SLC6A17 SLC6A16 HGF SLC5A7 SLC5A9 CES8 EPHA3 HEL-S-10 MGST3 MGST2 ADH7 SLC5A3 SLC5A4 NRG1 SLC2A9 HEL-S-128m SLC6A5 SLC6A7 SLC6A9 GSTM5 SRXN1 SLC2A6 EPHA2 SLC6A2 SLC2A7 UGT2B7 SLC2A8 SLC2A14 SLC2A11 SLC2A10 SLC2A13 FGF13 HEL-S-25 SLC39A11 SLC39A10 SLC39A13 SLC39A12 ALDH3A1 SLC39A14 SLC39A2 SMVT SLC39A1 CES3 SLC5A12 SLC39A3 SLC5A10 GSTA5 GSTA4 GSTA3 CYP4A11 GSTM1 ME1 HBEGF HMOX1 UGT1A1 NQO1 KEAP1 GSTM4 GCLC ABCC3 ABCC2 CYP2A6 RXRA FTL NR1C2 UGT1A4 UGT1A3 HSP90AB1 UGT1A9 UGT1A7 SLC2A12 SLC6A8 SLC6A19 HEL-75 HEL126 PTGR1 CES2 CES1 SLC6A3 MAFG MAFF NFE2L2 SLC2A4 GSTM3 SLC2A2 HEL-S-22 SLC2A3 TGFB1 ABCC5 SOLUBLE ACE2 MEDIATED CELL ENTRY OF SARS COV 2%WIKIPATHWAYS_20260610%WP5076%HOMO SAPIENS Soluble ACE2 mediated cell entry of SARS CoV 2 ADAM17 AGTR1 AVPR1B ACE2 GLIAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260610%WP2276%HOMO SAPIENS Glial cell differentiation CNP MBP FREP1 HEL70 GAP43 DRUG INDUCTION OF BILE ACID PATHWAY%WIKIPATHWAYS_20260610%WP2289%HOMO SAPIENS Drug induction of bile acid pathway NR1i1 ABCC3 CYP3A4 ABCC2 NR1I3 BAAT CYP7A1 ABCB1 NR1i2 NR1H4 ABCB11 SLCO1B1 SULT2A1 SLC51A SLC51B DISRUPTION OF POSTSYNAPTIC SIGNALING BY CNV%WIKIPATHWAYS_20260610%WP4875%HOMO SAPIENS Disruption of postsynaptic signaling by CNV CAMK2A GRIN2B CYFIP1 FMR1 ARC SYNGAP1 YWHAG NRXN1 NRXN2 MAPK1 CAMK2D MAPK3 RYR2 TJP1 SHANK1 NRXN3 RPH3A CAMK2G STX1A DLGAP1 GRIN1 DLG2 NLGN3 NLGN2 NLGN1 HOMER1 TRANSCRIPTION FACTORS REGULATE MIRNAS RELATED TO CARDIAC HYPERTROPHY%WIKIPATHWAYS_20260610%WP1559%HOMO SAPIENS Transcription factors regulate miRNAs related to cardiac hypertrophy RASGRF1 NFKB1 PPP3R1 MYEF2 STAT3 TGFB1 BDNF TRKB SIGNALING%WIKIPATHWAYS_20260610%WP3676%HOMO SAPIENS BDNF TrkB signaling PLCG1 DLG4 RPS6KA1 SOS1 ARC EEF2K CREB1 MAP2K1 SHC1 TSC2 TSC1 NRAS MAPK1 NTRK2 EIF4EBP1 MTOR RHEB ADCY1 GRB2 GAB2 GRIN1 BDNF HRAS TRPC6 TRPC3 HOMER1 RPS6KB1 RETINOL METABOLISM%WIKIPATHWAYS_20260610%WP5188%HOMO SAPIENS Retinol metabolism SDR16C5 AWAT2 CYP3A7 BCO1 CYP1A1 RPE65 AOX1 RDH12 LRAT CYP2A6 CYP2W1 DHRS9 HEL-S-53e DHRS4 ADH1A PNPLA4 ID SIGNALING%WIKIPATHWAYS_20260610%WP53%HOMO SAPIENS ID signaling ELK3 CCNE1 PAX8 PAX5 RB1 ID1 CDK2 MYOD1 RBL2 GIG8 ID3 RBL1 PAX2 GLYCOSAMINOGLYCAN DEGRADATION%WIKIPATHWAYS_20260610%WP4815%HOMO SAPIENS Glycosaminoglycan degradation HGSNAT HPSE2 IDUA GNS SGSH GALNS HYAL2 HYAL4 HPSE GUSB HEL-S-111 HEXA GLB1 LUNG PATHOLOGY OF COVID 19%WIKIPATHWAYS_20260610%WP5146%HOMO SAPIENS Lung pathology of COVID 19 TBK1 MAVS IL6 CXCL11 RIGI IRF3 TLR8 IFIH1 TLR3 IL1B CGAS MITA TLR7 CXCL9 CSF2 NFKB1 IL18 CCL2 TNF ALLOGRAFT REJECTION%WIKIPATHWAYS_20260610%WP2328%HOMO SAPIENS Allograft rejection TUBA1B HLA-DQB1 HARS1 IL22 HLA-DMA HLA-DMB ABCB1 PRF1 GNLY MICA IL1B CXCL9 C1QA HLA-DPB1 FOXP3 CXCL8 PECR CXCL13 STAT1 TNF CTLA4 CXCR5 CCL19 IL10 IL2 CCL21 PDGFRA HEL-S-62p VEGFA IL-21 LRRK2 PRKCZ CXCL11 CXCL12 C4A HLA-DOA HLA-DOB HLA-B HLA-C CD40 BHMT2 CD80 HLA-A HLA-F HLA-G HLA-E C4B_2 IL5 C1QB CD40LG IL2RA HLA-DQA2 HLA-DQA1 HLA-DRB5 IL12B IL12A IL4 IL13 TGFB1 AGTR1 C8A C6 HLA-DRB1 C7 C9 IL17A CASP9 CSNK2A2 CASP8 CASP3 GABPA CD55 IL1A C1QC TNFSF6 HLA-DPA1 IFNG GDNF HEL113 TRANSCRIPTIONAL REGULATION OF MEMORY B CELL DIFFERENTIATION%WIKIPATHWAYS_20260610%WP5491%HOMO SAPIENS Transcriptional regulation of memory B cell differentiation MEF2B POU2F2 IRF4 IL6 MYC TNFRSF13C CD79B SPIB BCR POU2AF1 IRF8 TLR10 CCND3 LYN TLR4 CCND2 NFKB1 CD79A MEF2C SPI1 CD40 CDKN2A STAT3 TCF4 IL21R TLR9 TLR8 TLR5 TLR3 ID3 TCF3 TLR7 CDKN1A CDKN1B SYK BCL6 TLR1 BCL2L1 EZH2 22Q11 2 DISTAL CNV%WIKIPATHWAYS_20260610%WP5546%HOMO SAPIENS 22q11 2 distal CNV CAMK2A ELOC SNRPB2 RPS15 RPS14 RPS17 RPS16 CD79A RPS19 RPS18 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 GNAZ RPSA SNRNP200 PDIA2 XBP1 SOX9 HEL-S-99n RSPH9 CBL DNAJB11 RPS15A RPS3 RPS2 RPS27A RSPH3 SNW1 RPS26 RPS28 RPS29 CHEK1 RPS20 FAU RPS21 RPS24 RPS23 ARIH1 RPS6 CAMK1 MDM2 HEL-S-125m HEL-S-89n CD79B PARK2 BCR PAK1 NEDD4 RNF19B VPREB1 SNRPD2 MAPK1 SNRPD1 CWC22 ROPN1L SNRPD3 RSPH6A XAB2 CRNKL1 PDIA4 RAB36 SNRPG PPIE SNRPE DYDC1 SNRPF SNRPB UBA6 CABP1 PRPF8 AK8 SDF2L1 CWC15 WDR57 TDRD3 RSPH14 HYOU1 GGTLC2 ZNF280A IQUB DHX16 PTPA HEL-S-107 CCDC116 BUD31 UBE2L3 PLRG1 NME5 YDJC CANX SNRPA1 RBM22 AQR SF3B5 SF3B2 LRP4 PPM1F RNF113A RILP UGGT1 PPIL1 SF3A1 SF3A2 CDC5L IGLL5 PHF5A RBX1 IGLL1 YPEL1 PPIL4 PPIL6 UBE3A PPIB DNAJB13 CAMK4 MAPK PATHWAY IN CONGENITAL THYROID CANCER%WIKIPATHWAYS_20260610%WP4928%HOMO SAPIENS MAPK pathway in congenital thyroid cancer ALK JUN SOS1 SOS2 GAREM2 MYC MAP2K1 MAP2K2 SHC1 KSR1 MAPK3 RAF1 FOS PARTHANATOS CELL DEATH SIGNALING PATHWAY%WIKIPATHWAYS_20260610%WP5585%HOMO SAPIENS Parthanatos cell death signaling pathway AIFM1 HFE EFFECT ON HEPCIDIN PRODUCTION%WIKIPATHWAYS_20260610%WP3924%HOMO SAPIENS Hfe effect on hepcidin production HAMP BMP6 ID1 TMPRSS6 HFE ENTEROCYTE CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260610%WP5333%HOMO SAPIENS Enterocyte cholesterol metabolism ABCG8 FDPS ABCG5 MVK HSD17B7 TM7SF2 PMVK DHCR24 DHCR7 ACAT2 NPC1L1 HMGCS1 MGAT1 FABP2 DKFZp434B2017 CD36 SLC27A4 CYP51A1 MTTP HMGCR EBP APOB LDLR ABCA1 FDFT1 DGAT1 LBR APOA4 SQLE SC5D MSMO1 MVD CATABOLISM OF SKELETAL MUSCLE IN CACHEXIA%WIKIPATHWAYS_20260610%WP5474%HOMO SAPIENS Catabolism of skeletal muscle in cachexia REL IL6 RELB MSTN IL1B IGF1 CEBPB AKT1S1 NFKB1 NFKB2 MLST8 TNFRSF12A FOXO3A TNF STAT3 IKBKB IKBKG SMAD2 MTOR CHUK EP300 TRIM63 IL6R FBXO32 RELA ACVR2A NFKBIA IL1R1 RPTOR MAPK11 SMAD4 IL1A JAK1 MAP1LC3A IGF1R TNFSF12 TNFRSF1A FOXP3 IN COVID 19%WIKIPATHWAYS_20260610%WP5063%HOMO SAPIENS FOXP3 in COVID 19 IL6ST STAT5B IL2RA IL2RB IL7R FOXP3 IL6R IL6 CD80 STAT3 IL2RG IL2 SULINDAC METABOLIC PATHWAY%WIKIPATHWAYS_20260610%WP2542%HOMO SAPIENS Sulindac metabolic pathway CYP1A2 MSRB3 MSRA CYP1B1 MSRB2 IL11 SIGNALING%WIKIPATHWAYS_20260610%WP2332%HOMO SAPIENS IL11 signaling PDPK1 YES1 ATF1 RPS6KA1 IL11RA CREB1 MAP2K1 MAP2K2 PIK3R2 ITGA2 PIK3R1 BIRC5 MAPK1 IL11 MAPK3 RPS6 RAF1 STAT1 STAT3 IKBKB FES PTPN11 IL6ST CHUK BCL2 RELA TYK2 GRB2 IBSP TGFB1 PTPA PIAS1 SOCS3 SRC FYN HRAS RUNX2 JAK1 BGLAP RPS6KB1 REGULATION OF CYTOTOXIC T CELL RESPONSES BY MALAT1 MIR 15 16 CIRCUIT %WIKIPATHWAYS_20260610%WP5489%HOMO SAPIENS Regulation of cytotoxic T cell responses by Malat1 miR 15 16 circuit SPN CD3G CD27 CD3E CD80 CD3D BCL2 IL2 LUPUS THERAPIES%WIKIPATHWAYS_20260610%WP5560%HOMO SAPIENS Lupus therapies IL6 C4A CD22 C1QA CD40 CD80 IL23A C4B_2 C1QB CD40LG TNLG7A IL6R CD19 IL25 IL12B IL12A IL17F IL17D IL17C HEL-S-62p IL17B IL17A MS4A1 C1QC IFNG EGFR TYROSINE KINASE INHIBITOR RESISTANCE%WIKIPATHWAYS_20260610%WP4806%HOMO SAPIENS EGFR tyrosine kinase inhibitor resistance PIK3CA SOS1 AXL MAPK1 MAPK3 EGFR BAD ARAF STAT3 AKT3 RRAS MTOR BAX IL6R SOS2 BCL2L11 PIK3CD PDGFRA RPS6KB2 SRC FGF2 EIF4E SHC4 IGF1R VEGFA KDR BCL2L1 RPS6KB1 PRKCB PLCG1 PDGFD FGFR2 PDPK1 PDGFC PRKCA IL6 ERBB3 CCND1 ERBB2 EGF PLCG2 MYC MAP2K1 NF1 GSK3B MAP2K2 SHC2 TGFA SHC3 PIK3R3 SHC1 PIK3R2 IGF1 HGF RRAS2 NRG2 PIK3R1 NRAS FOXO3A RPS6 RAF1 NRG1 EIF4EBP1 FGFR3 PDGFA BCL2 GRB2 PTEN HRAS JAK1 LINOLEIC ACID METABOLISM AFFECTED BY SARS COV 2%WIKIPATHWAYS_20260610%WP4853%HOMO SAPIENS Linoleic acid metabolism affected by SARS CoV 2 ELOVL5 FADS1 ELOVL2 ACE2 FADS2 ANTIVIRAL AND ANTI INFLAMMATORY EFFECTS OF NRF2 ON SARS COV 2 PATHWAY%WIKIPATHWAYS_20260610%WP5113%HOMO SAPIENS Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway GUCY1B1 HMOX1 GUCY1A2 TMPRSS2 NQO1 GCLM KEAP1 IL6 GCLC SLC7A11 IL1B MMP3 RXRA NFE2L2 NFKB1 CXCL8 TNF IKBKB IKBKG CHUK ACE2 IRF3 IL12A RELA NFKBIA CCL2 SPINA BIFIDA%WIKIPATHWAYS_20260610%WP5150%HOMO SAPIENS Spina bifida SHMT1 MTHFD1 MTR AHCYL2 MTRR DNMT3B MAT1A DENGUE 2 INTERACTIONS WITH COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260610%WP3896%HOMO SAPIENS Dengue 2 interactions with complement and coagulation cascades CLU C3AR1 CR1 PLAT F3 CD46 CFH C1QA CFI C5AR1 THBD SERPIND1 APOA2 CR2 HEL-S-62p SERPINA1 SERPINF2 PLAUR F5 F8 F9 CPB2 SERPINC1 TFPI LMAN1 F10 PROC F7 PLG HEL-S-78p VWF C4B_2 C1QB CFD C1S F13B C6 CLTC C8G C7 F2R C9 MASP2 MASP1 F2 CFB CD55 KNG1 C1QC BDKRB1 SERPING1 KLKB1 PROS1 DRAVET SYNDROME%WIKIPATHWAYS_20260610%WP5200%HOMO SAPIENS Dravet syndrome CAMK2A PRR5 STXBP1 PIK3CA PRKCA MAPKAP1 SCN1A KCNA2 PCDH19 SCN3A NFKB1 RICTOR SCN1B MLST8 SCN2B TNF MTOR SCN3B SCN8A FGF13 SCN2A SCN4B CALM1 SNTA1 HCN1 CHD2 MAPK11 NRXN1 DELETION SYNDROME%WIKIPATHWAYS_20260610%WP5398%HOMO SAPIENS NRXN1 deletion syndrome GRIN2B GRIN3B GRIN3A NRXN1 DLG4 GRIN1 GRIA2 NLGN3 NLGN2 GRIA3 NLGN1 GRIA4 ESTROGEN RECEPTOR PATHWAY%WIKIPATHWAYS_20260610%WP2881%HOMO SAPIENS Estrogen receptor pathway GPAM CYP1A2 PCK1 JUN ACOX1 CYP1A1 CYP1B1 PDK4 SP1 NR1C1 STAT3 NR0B2 PURINE METABOLISM%WIKIPATHWAYS_20260610%WP4792%HOMO SAPIENS Purine metabolism AMPD1 APRT DGUOK PNP IMPDH1 XDH ADSS ADA ADSL HEL-S-70p NANOMATERIAL INDUCED APOPTOSIS%WIKIPATHWAYS_20260610%WP2507%HOMO SAPIENS Nanomaterial induced apoptosis AIFM1 DIABLO BAX PRF1 BCL2 CASP6 CYCS BAK1 HTRA2 CASP9 CASP8 APAF1 CASP3 TNFSF6 FADD IL4 SIGNALING%WIKIPATHWAYS_20260610%WP395%HOMO SAPIENS IL4 signaling PTPN6 PIK3CA SOS1 INPP5D FLNA SHC1 PIK3R2 PIK3R1 CEBPB MAPK1 NFKB1 MAPK3 ATF2 SOCS5 BAD STAT1 IL2RG STAT3 IKBKB FES PTPN11 MAPK14 CHUK EP300 CEBPA IRS1 PIK3CD RELA TYK2 IL4 NFKBIA GRB2 GAB2 STAT5B CBL SOCS3 SOCS1 JAK3 MAPK11 JAK1 FOS RPS6KB1 ATM SIGNALING IN DEVELOPMENT AND DISEASE %WIKIPATHWAYS_20260610%WP3878%HOMO SAPIENS ATM signaling in development and disease KAT5 PPP5C RNF168 CHEK2 CHEK1 STK11 TSC2 NFKB1 ATF2 TRIM28 NBN HMGN1 MDC1 RIF1 NHEJ1 RNF20 SMC1A PRKDC ATMIN CEP63 AURKB MRE11A PPP2CA MAPK14 IKBKG MTOR RAD50 RNF8 PPM1D CDK2 LMNB2 RBBP8 TP53BP1 CDK5 ATM ATR HEL-S-102 MAPK12 MAPK13 MAPK11 IRON METABOLISM DISORDERS%WIKIPATHWAYS_20260610%WP5172%HOMO SAPIENS Iron metabolism disorders PANK2 TF TFRC STEAP3 HFE TFR2 FTH1 SLC40A1 UQCRFS1 CP HAMP SLC11A2 FTL CYBRD1 HEPH VITAMIN D SENSITIVE CALCIUM SIGNALING IN DEPRESSION%WIKIPATHWAYS_20260610%WP4698%HOMO SAPIENS Vitamin D sensitive calcium signaling in depression GRIN2B CHRM1 NR1i1 GCLC SLC8A1 ATP2B1 CYP27A1 ATP2B3 ITPR2 RXRA ATP2B2 NFE2L2 CYP27B1 TPH2 TPH1 CACNA1C KDM3A KDM1B CALB1 ATP2B4 PVALB KCNQ2 KCNQ3 KDM1A BCL2 KDM6B GRIN1 HEL-75 UREA CYCLE AND METABOLISM OF AMINO GROUPS%WIKIPATHWAYS_20260610%WP497%HOMO SAPIENS Urea cycle and metabolism of amino groups SRM OTC SMS ASL NAGS ALDH18A1 HEL-S-5 ASS1 GLUD1 ARG2 ARG1 HEL-S-20 HEL-S-29 CODEINE AND MORPHINE METABOLISM%WIKIPATHWAYS_20260610%WP1604%HOMO SAPIENS Codeine and morphine metabolism SLCO1B1 UGT2B4 UGT1A3 UGT1A1 UGT2B7 UGT1A9 UGT1A8 ABCC3 CYP3A4 ABCC2 ABCB1 UGT1A10 COCAINE METABOLISM%WIKIPATHWAYS_20260610%WP2826%HOMO SAPIENS Cocaine metabolism BCHE CYP3A4 CES2 CES1 THYMIC STROMAL LYMPHOPOIETIN TSLP SIGNALING%WIKIPATHWAYS_20260610%WP2203%HOMO SAPIENS Thymic stromal lymphopoietin TSLP signaling YES1 RELB MAP2K1 MAP2K2 MAPK8 LYN MAPK1 NFKB1 NFKB2 MAPK3 RPS6 STAT1 STAT3 FES EIF4EBP1 PTPN11 MAPK14 IL7R BTK TEC CRLF2 RELA MAPK9 NFKBIA GAB2 STAT5B LCK STAT4 SRC FYN JAK1 TSLP KININ KALLIKREIN PATHWAY%WIKIPATHWAYS_20260610%WP5089%HOMO SAPIENS Kinin Kallikrein pathway KNG1 BDKRB2 BDKRB1 SERPING1 KLKB1 CPN1 B CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260610%WP23%HOMO SAPIENS B cell receptor signaling CAMK2A RAPGEF1 SOS1 CRK INPP5D CDC42 CREB1 CD79B MAPK8 HCLS1 MAPK1 CD79A IKBKB PTPN11 MAPK14 IKBKG CHUK GTF2I LAT2 RELA GAB2 VAV1 CR2 LCK CBL BCL6 FYN BLK MAP2K6 RASGRP3 PTPRC PRKCB PLCG1 REL NFATC3 PTPN6 PIK3AP1 CARD11 NFATC2 PDPK1 RPS6KA1 PIP5K1C BCL10 CRKL PLCG2 MYC MAP2K1 GSK3B CD81 MAP2K2 SHC1 PIK3R2 CD22 NCK1 PIK3R1 FOXO1 LYN NFKB1 ATF2 RAF1 GSK3A STM7 PIP5K1A JUN BTK CD19 TEC DAPP1 BASH PTPN18 MAPK9 NFKBIA GRB2 MAPK4 MAP3K7 SYK HRAS MAP4K1 RAC1 VAV2 MAX 3Q29 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260610%WP4906%HOMO SAPIENS 3q29 copy number variation syndrome DYNLT2B DYNC2LI1 DNCL1 RNF8 STAT5B ADAM10 SIRT1 HIF1A DYNLRB2 RNF168 MYC HFE PIK3R3 DYNLT1 PXN MCRS1 H2BC21 DYNLT3 DYNLL2 JUN TF CEP19 TFRC NRROS SLC40A1 PIGX UBXN7 TGFB1 SMCO1 DYNC2H1 NCBP1 HAMP NCBP2 RABL2B FBXW7 FNDC8 HEL-S-71 PIGM MFI2 NF2 MYCBP2 FBXO45 SLC51A ZDHHC19 SLC51B BRINP1 DYNC2I2 TM4SF19 CEP350 MAD2L1BP WDR53 ZNF76 ROTENONE METABOLISM%WIKIPATHWAYS_20260610%WP5486%HOMO SAPIENS Rotenone metabolism CYP3A4 CYP2C19 OREXIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260610%WP5094%HOMO SAPIENS Orexin receptor pathway NPVF HCRT OPRK1 HCRTR2 HCRTR1 BMPR1A CREB1 LHB GNAS IL1B TH PRKAA1 MAPK8 GNRH1 MAPK1 CXCL8 MAPK3 DAGLA DKFZp686L0365 CXCL2 GH1 TNF STAT3 CCK GNAI1 PTPN11 STAR MAPK14 MTOR IL10 PRKD1 VHL SMAD1 IL9 SLC1A2 RUNX2 HIF1A EIF4B RPS6KB1 PRKCB PDPK1 PRKCA RPS6KA1 PRKCZ IL6 POMC DKFZp781O1323 MAP2K1 MAP2K2 PIK3R2 PIK3R1 GCG NFE2L2 FOXO1 CAMKK2 NOX4 SLC2A4 LEP RPS6 DYNLT1 NPY DYNLT3 EIF4EBP1 GHRL PRKCE GNA11 MAPK9 MAPK7 IL4 BMP7 SGK1 CASP9 FSHB CASP3 CGA BGLAP NPFFR1 PARKIN UBIQUITIN PROTEASOMAL SYSTEM PATHWAY%WIKIPATHWAYS_20260610%WP2359%HOMO SAPIENS Parkin ubiquitin proteasomal system pathway TUBA3E TUBA1C PSMD7 TUBB6 TUBA1B TUBA1A PSMD9 TUBB1 PSMD6 TUBB PSMD4 PSMD5 RNF19A PSMD3 TUBB4B PSMD1 TUBB4A CASK TUBA4A TUBA4B TUBB2A PSMD10 SNCA PARK2 PSMD11 HSPA14 TUBA2 PSMC1 PSMD12 TUBA8 PSMD13 PSMC6 SEPT5 PSMC4 UBE2L6 UBE2J2 UBE2L3 GPR37 UBE2G1 UBE2G2 PSMD2 SIAH2 HSPA2 HEL-S-72p CCNE1 HSPA1A HSPA4 FBXW7 SNCAIP CASP8 STUB1 HEL-S-89n HEL-S-91n TUBAL3 TUBB8 UBE2J1 SIAH1 PENTOSE PHOSPHATE PATHWAY IN SENESCENT CELLS%WIKIPATHWAYS_20260610%WP5043%HOMO SAPIENS Pentose phosphate pathway in senescent cells HEL-S-304 RPE PRPS1L1 DERA RPIA INTERLEUKIN 1 IL 1 STRUCTURAL PATHWAY%WIKIPATHWAYS_20260610%WP2637%HOMO SAPIENS Interleukin 1 IL 1 structural pathway MAP2K4 MAPK10 MYD88 MAP3K8 MYC RPS6KA5 MAP2K1 MAPKAPK2 MAP2K2 MAPK8 TAB3 NFKBIB MAPK1 SAFB NFKB1 MAPK3 MAP3K14 ATF2 IKBKB IRAK2 MAP3K7IP1 MBP MAPK14 CHUK IRAK4 MAP2K3 RELA MAPK9 NFKBIA TRAF6 IRF7 MAP3K7 IL1R1 TANK MAPK11 EIF4E IL1A IRAK1 MAP2K6 MAP3K1 FOS TRANSCRIPTION CO FACTORS SKI AND SKIL PROTEIN PARTNERS%WIKIPATHWAYS_20260610%WP4533%HOMO SAPIENS Transcription co factors SKI and SKIL protein partners SIN3A HDAC3 LATS2 SKI TEAD2 SKIL TEAD3 TEAD4 LATS1 HDAC1 NF1 MERTK FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260610%WP143%HOMO SAPIENS Fatty acid beta oxidation LPL CPT1A ECHS1 CRAT GPD2 ACSS2 ACSL1 ACSL6 FACL4 ACSL5 ACSL3 LIPF LIPE LIPC CHKB ACADVL PNPLA2 CPT2 ACADL SLC25A20 ACADS DLD ACADM GCDH ACAT1 HADHB DECR1 HEL-S-49 TELOMERE END PACKAGING AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260610%WP5567%HOMO SAPIENS Telomere end packaging and neurodevelopmental disorders H2AC6 TERF2IP H2BC12 H2AX TERF1 H2AZ1 H2AC19 H2AZ2 ACD TPP1 H2AB1 H2AC14 H2BC26 H2BC12L H2AJ H2BC21 HIST1H2AB H2BC17 H2BC13 H2BC14 H2BC15 H2BC11 HIST1H2BE H4C9 H2BC9 H2BC8 H2BC3 H2BC1 HIST1H4L H2AC20 H3-4 TERF2 CYSTEINE AND METHIONINE CATABOLISM%WIKIPATHWAYS_20260610%WP4504%HOMO SAPIENS Cysteine and methionine catabolism ETHE1 SUOX CDO1 pcap CTH MTR HEL-S-64p GCLC CBS HEL-S-61p SQOR MAT1A MODULATION OF PI3K AKT MTOR SIGNALING BY BIOACTIVE SPHINGOLIPIDS%WIKIPATHWAYS_20260610%WP5192%HOMO SAPIENS Modulation of PI3K Akt mTOR signaling by bioactive sphingolipids MTOR PIK3CA TSC1 S1PR1 NFKB1 S1PR3 ASAH2 HIF1A SPHK2 CERK IGF1R LASS1 DUAL HIJACK MODEL OF VIF IN HIV INFECTION%WIKIPATHWAYS_20260610%WP3300%HOMO SAPIENS Dual hijack model of Vif in HIV infection UBB CBFB CUL5 RUNX1 RBX1 ELOC APOBEC3G HYPOTHESIZED PATHWAYS IN PATHOGENESIS OF CARDIOVASCULAR DISEASE%WIKIPATHWAYS_20260610%WP3668%HOMO SAPIENS Hypothesized pathways in pathogenesis of cardiovascular disease LTBP2 NR2C2 MAPK14 LTBP1 SMAD2 ENG TGFBR2 FLNA POSTN CTGF SHC1 MAPK8 AGTR1 MAPK1 TGFBR1 MAPK3 SMAD4 ANGPT2 FBN1 RUNX2 FBN2 FBN3 TGFBR3 GLYCOSAMINOGLYCAN SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260610%WP5395%HOMO SAPIENS Glycosaminoglycan synthesis in fibroblasts XYLT1 CSGALNACT1 B3GAT3 XYLT2 CHST11 B3GALT6 CHSY1 CHST14 CHST3 HS3ST3A1 CHPF HS6ST1 HS6ST2 HS2ST1 HS6ST3 EXTL2 EXTL1 CHST12 NDST3 EXT1 CHSY3 CHST13 EXT2 HS3ST3B1 CHST7 CHPF2 B3GAT2 GLCE B3GAT1 CSGALNACT2 CHST1 HS3ST1 HS3ST2 UST LUPUS PATHOGENESIS%WIKIPATHWAYS_20260610%WP5559%HOMO SAPIENS Lupus pathogenesis CD40LG TNLG7A IL6 TLR9 TNFRSF13C BCR IFNA2 TLR7 PDCD1 TLR4 IL17A ICOS CD40 CD80 OSX AND MIRNAS IN TOOTH DEVELOPMENT%WIKIPATHWAYS_20260610%WP3971%HOMO SAPIENS OSX and miRNAs in tooth development NOTCH4 NOTCH2 SP7 NOTCH1 SOST KLF4 HNF1A DMP1 BMP7 DKK1 DSPP RUNX2 ALPL NOTCH3 TGF BETA RECEPTOR SIGNALING%WIKIPATHWAYS_20260610%WP560%HOMO SAPIENS TGF beta receptor signaling TGFBR2 NOG SMAD6 SKI SKIL MAPK3 FOXH1 STAT1 TNF STAT3 LTBP1 ENG EP300 LEF1 LEFTY1 SMAD1 CREBBP FKBP1A SMAD4 ZFYVE9 RUNX2 TGIF1 BAMBI INHBA LEFTY2 THBS1 SMAD9 EGF DKFZp781O1323 ZNF423 opn RUNX3 TGFBR1 NFKB1 ITGB6 SMAD2 JUN ZEB2 MAPK9 TGFB1 FST BMP4 HRAS JAK1 IFNG WNT1 LIF FOS TGFBR3 HIF1A AND PPARG IN HYPERTROPHIC CARDIOMYOPATHY%WIKIPATHWAYS_20260610%WP2456%HOMO SAPIENS HIF1A and PPARG in hypertrophic cardiomyopathy HMFN0839 GPD1 HEL-S-133P PPARG HIF1A CD36 HEL-S-162eP HEL-S-49 OSTEOPONTIN SIGNALING%WIKIPATHWAYS_20260610%WP1434%HOMO SAPIENS Osteopontin signaling CHUK MAPK1 opn NFKB1 ITGB3 MAP3K14 MAPK3 ITGAV MAP2K1 MMP9 RELA IKBKB CELIAC DISEASE MECHANISM AND THERAPIES%WIKIPATHWAYS_20260610%WP5562%HOMO SAPIENS Celiac disease mechanism and therapies ITGA4 IL-21 DHODH ITGB7 EGFR IFNG F2RL1 TNF IL2 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES INTERFERON INDUCTION%WIKIPATHWAYS_20260610%WP4880%HOMO SAPIENS Host pathogen interaction of human coronaviruses interferon induction MYD88 STAT2 IKBKE MAVS RIGI MAPK8 NFKB1 STAT1 IKBKB TBK1 MAPK14 IKBKG JUN CHUK IFNAR2 TICAM1 EIF2AK2 IRF3 IFIH1 TRAF3 TYK2 NFKBIA TRAF6 TLR7 OAS1 MAP3K7 IFNAR1 IRF9 OAS2 JAK1 RIPK1 OAS3 FOS SPLICING FACTOR NOVA REGULATED SYNAPTIC PROTEINS%WIKIPATHWAYS_20260610%WP4148%HOMO SAPIENS Splicing factor NOVA regulated synaptic proteins NCDN GRIN2B STX2 KCNJ6 NTNG1 TERF2IP CADM3 CADM1 PLCB4 SNW1 KCNMA1 PRKCZ DAB1 CSN3 AGRN CASK GRIK2 ATP2B1 GABBR2 EFNA5 CAMK2G GPHN MAP4 KCNQ2 CAV2 CDH2 MAPK9 MAPK4 GRIN1 RAP1GAP CLASP1 CHL1 CELL INTERACTIONS IN PANCREATIC CANCER MICROENVIRONMENT%WIKIPATHWAYS_20260610%WP5284%HOMO SAPIENS Cell interactions in pancreatic cancer microenvironment IFITM2 BAG3 CSF1R CXCL12 CSF2RA TGFB1 CCR5 HLA-DRB1 CSF2 CSF1 CXCR4 CCR2 CCL5 ITGB6 NRP1 CD80 TNFSF6 CCL2 CXCR3 VEGFA CTLA4 KDR IL5 SIGNALING%WIKIPATHWAYS_20260610%WP127%HOMO SAPIENS IL5 signaling RPS6KA1 SOS1 SPRED1 CSF2RB MAP2K1 GSK3B MAP2K2 SHC1 PIK3R2 PIK3R1 LYN MAPK1 MAPK3 FOXO3A RPS6 RAF1 GSK3A STAT1 IL5RA STAT3 PTPN11 JUN BTK IL2 GRB2 STAT5B SYK RPS6KB2 JAK1 RPS6KB1 G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20260610%WP45%HOMO SAPIENS G1 to S cell cycle control CDK7 CDKN2D POLE CDKN1C CREB1 WEE1 E2F3 CDKN2B PRIM2 PRIM1 CDKN2A CREB3 ATF6B POLA2 POLE2 CCNH MCM7 ORC1L RB1 CCND1 MYT1 MYC TFDP1 CDKN2C TFDP2 MNAT1 PCNA CDC45 CCNG2 CCND3 E2F2 CCND2 RPA1 RPA3 CREB3L3 CCNE2 CREB3L4 CCNE1 CCNB1 CDC2 MCM3 GADD45A CDK4 MCM5 CDK2 MCM6 CDK6 MDM2 ATM CDKN1A CDKN1B MCM2 ORC6 ORC3 ORC2 HSPB3 IN CHARCOT MARIE TOOTH DISEASE%WIKIPATHWAYS_20260610%WP5524%HOMO SAPIENS HSPB3 in Charcot Marie Tooth disease MYOG DES DMPK HEL25 HP1BP3 HSPB2 HSPB3 MYOD1 LBR LMNA H2AZ1 MEF2C ACTA1 NOTCH3 TP53 NETWORK%WIKIPATHWAYS_20260610%WP1742%HOMO SAPIENS TP53 network BOK PMAIP1 BAX GADD45A MYC BCL2 MDM2 ATM BBC3 TP73 CDKN1A TNFSF10 OTX2 TP63 SUMO1 CDKN2A WNT SIGNALING%WIKIPATHWAYS_20260610%WP428%HOMO SAPIENS Wnt signaling CAMK2A PLCB3 PLCB4 PLCB1 PLCB2 CSNK1A1 INVS CAMK2D APC PPP3CC WNT3A NLK FOSL1 PPP3R2 CSNK2A1 PPP3R1 CCND1 MYC CTNNBIP1 DAAM1 NFATC4 DAAM2 PRICKLE2 GPC4 CCND3 CCND2 FZD7 AXIN1 FZD8 SFRP4 DVL2 JUN MAPK9 FRAT2 SOX17 LRP5 CER1 CSNK2A3 CSNK2A2 LRP6 DKK1 DKK2 DKK4 SFRP1 SFRP5 FZD1 CSNK2B RAC1 KREMEN1 WIF1 ARHA MAPK8 RYK NOTUM CTBP2 ROR1 ROR2 DVL3 PORCN CHD8 SOST SENP2 LEF1 VANGL1 CXXC4 TCF7L2 TCF7L1 hCG_2014051 PRKCB NFATC3 NFATC2 NFATC1 PRKCA PPP3CA GSK3B WNT2B FZD10 WNT5B WNT16 WNT3 WNT4 WNT10B WNT10A FZD3 FZD5 WNT7B FZD9 WNT7A CAMK2G ROCK2 FRAT1 CTBP1 NKD1 NKD2 MAP3K7 DVL1 WNT1 FZD2 ALZHEIMER 39 S DISEASE AND MIRNA EFFECTS%WIKIPATHWAYS_20260610%WP2059%HOMO SAPIENS Alzheimer 39 s disease and miRNA effects TUBA3E MAPK10 TUBA1C TUBB6 TUBA1B TUBA1A PLCB3 PSMD9 PLCB4 TUBB1 PSMD6 TUBB PSMD4 PSMD3 TUBB4B KIF5A PSMD1 PLCB1 TUBB4A PLCB2 TUBA4A TUBB2A SNCA PSMC1 TUBA2 TUBA8 ERN1 TNF PPP3CC TRAF2 VDAC3 ATP2A1 XBP1 DDIT3 CACNA1F APH1B FADD PPP3R2 IRS4 CACNA1S PPP3R1 PSENEN IL6 BACE1 APP MAP3K5 PSEN2 PSEN1 LPL NRBF2 ATG2B MME PSMA2 KNS2 PSMA8 PSMB6 PSMB2 PSMB3 HEL-S-276 RTN3 GPR83 KLC4 KLC3 ADAM17 KLC2 NAE1 BECN2 HEL-S-61 AMBRA1 ADRM1 ATF4 SLC25A31 EIF2AK2 INS EIF2S1 MAPK9 FRAT2 CALM1 CSNK2A3 CSNK2A2 DKK1 DKK2 DKK4 CSNK2B PSMD7 IL1B PSMD12 PSMD13 DVL3 CALML6 CALML3 CALML4 MCU CSNK1A1L PPP3CA CYBB GSK3B WNT2B FZD10 PIK3R3 PIK3R2 WNT5B PIK3R1 ITPR2 NRAS WNT16 RB1CC1 WNT3 WNT4 ULK1 WNT10B WNT10A PPIF FZD3 FZD5 CACNA1C WNT7B FZD9 WNT7A RTN4 FRAT1 SLC25A5 HEL-S-91n DVL1 ATP2A2 FZD2 AXIN2 CSNK1A1 CSF1 PSMC6 APC PSMC4 AGER IRS1 PIK3CD HEL-S-162eP WNT3A SHFM1 HSD17B10 PSMD2 GRIN2B CSNK2A1 PIK3R4 WIPI1 MAP2K1 ULK2 MAP2K2 FZD7 AXIN1 FZD8 SFRP4 RAF1 APAF1 DVL2 CDK5R1 CDK5 CYCS LRP5 GRIN1 CASP9 LRP6 CASP8 CASP3 HRAS FZD1 CASP12 PIK3CA ATG101 WIPI2 ATG14 MAPK8 MAPK1 ATG2A MAPK3 BAD ARAF RYR3 IKBKB AKT3 MTOR CHUK RELA SLC25A6 hCG_2014051 ADAM10 APOE APC2 INSR NFKB1 NOX4 CHRNA7 PSMA4 NOS2 IL1A PTGS2 TUBAL3 WNT1 TUBB8 TNFRSF1A SLC25A4 AMINO ACID METABOLISM%WIKIPATHWAYS_20260610%WP3925%HOMO SAPIENS Amino acid metabolism OTC CAD DDC HDC CBS DBH TH OGDH SUCLG1 HEL-S-53e ADH5 MARS2 ACLY G6PC2 PC HMGCL ACSS1 ARG2 PNMT PIG59 HEL-S-61p TPO EHHADH MAOA FTCD ASNS FH EPRS1 HEL-S-30 HEL-75 GLS PDHA1 MDH2 CTH GOT2 HEL-S-26 HEL-S-133P GCLM TDO2 ASS1 GLUD1 ACO2 RARS1 PCK1 PDK4 HEL-S-64p ADH7 TPH1 BCAT1 HEL-S-4 GPT2 MCCC1 SRM LARS2 SMS ADH1C ALDH18A1 PPM1L VARS1 HAL IARS FARSB ARG1 SDHA P4HA2 ALDH7A1 DLD ACADM PDHX CS HEL-S-32 ALTERNATIVE PATHWAY OF FETAL ANDROGEN SYNTHESIS%WIKIPATHWAYS_20260610%WP4524%HOMO SAPIENS Alternative pathway of fetal androgen synthesis STAR AKR1C2 SRD5A2 AKR1C4 HSD3B2 POR HSD17B3 HSD17B6 CYP17A1 CYP11A1 MECHANOREGULATION AND PATHOLOGY OF YAP TAZ VIA HIPPO AND NON HIPPO MECHANISMS%WIKIPATHWAYS_20260610%WP4534%HOMO SAPIENS Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms MAPK10 LIMD1 TEAD2 TEAD3 TEAD4 ITGB1 CTNNA1 YWHAQ MAPK8 PAK1 ITGB4 ITGB7 ITGB8 ITGB6 HEL-S-31 ACTG2 WWTR1 MAP4K2 ACTA2 LATS1 PAK6 ACTG1 MAPK9 PAK4 SGMS1 PS1TP5BP1 MAP4K3 NF2 YAP1 ITGB3 SRC ACTA1 MAP4K1 ERBB SIGNALING%WIKIPATHWAYS_20260610%WP673%HOMO SAPIENS ErbB signaling CAMK2A MAPK10 PIK3CA HBEGF ERBB4 SOS1 CRK MAPK8 PAK1 MAPK1 CAMK2D MAPK3 EGFR BAD ARAF AKT3 MTOR SOS2 BCL2L11 PIK3CD NRG3 STAT5B CBL RPS6KB2 SRC SHC4 RPS6KB1 MAP2K4 PRKCB PDPK1 PRKCA CRKL ERBB3 CCND1 ERBB2 EGF PLCG2 MYC MAP2K1 GSK3B MAP2K2 SHC2 TGFA EREG SHC3 PIK3R3 BTC SHC1 PIK3R2 NCK2 NCK1 NRG2 PIK3R1 FOXO1 NRAS RAF1 NRG1 EIF4EBP1 AREG CAMK2G JUN PAK6 MAPK9 PAK4 MDM2 NRG4 GRB2 ABL2 CDKN1A CDKN1B HRAS OVERVIEW OF PROINFLAMMATORY AND PROFIBROTIC MEDIATORS%WIKIPATHWAYS_20260610%WP5095%HOMO SAPIENS Overview of proinflammatory and profibrotic mediators CXCL6 CXCL9 IL1RN CSF2 CSF1 CXCL8 IL36A CXCL17 IL36B CTF1 CXCL1 CXCL13 CXCL3 IL23A CXCL2 TNF CXCL5 IL10 IL36RN IL37 IL36G IL2 IL1F10 IL9 CCL5 CCL4 CCL3 CCL2 IFNB1 PPBP IL6 CXCL11 CXCL12 PF4 MMP3 IFNA5 IFNA4 IL4 IFNA7 CNTF IFNA6 CCL3L3 IFNA1 IFNA2 CCL17 IFNA8 CCL16 IL18 TSLP IFNG OSM LIF CSF3 EPO IL22 IL20 IFNA13 IL26 IFNA14 IL24 IFNA16 IL27 IFNA17 IL1B CX3CL1 IFNA10 PF4V1 IL11 IFNA21 IL19 CCL14 CCL13 IL7 CCL11 TNFSF13 TNLG7A CCL19 CCL18 CCL15 CCL25 IL33 CCL24 CCL23 IL31 CCL22 CCL21 IL3 CCL27 CCL26 MMP9 CCL4L2 VEGFA CXCL14 IL-21 CXCL16 EBI3 IFNW1 opn NFKB1 IFNK LTA XCL2 XCL1 IL5 AREG IFNL2 CCL8 IFNL1 CCL7 IL25 CCL1 IL12B IFNL3 IL12A CCL20 TGFB1 IL13 IL17F IL17D IL17C CCL28 IL17B IL17A IL1A KREBS CYCLE DISORDERS%WIKIPATHWAYS_20260610%WP4236%HOMO SAPIENS Krebs cycle disorders SUCLA2 SUCLG1 PDHX HEL-S-133P DHTKD1 FH MPC1 GPT PCK2 SUCLG2 HEL-S-281 LIPID PARTICLES COMPOSITION%WIKIPATHWAYS_20260610%WP3601%HOMO SAPIENS Lipid particles composition LPL APOC2 APOB APOE LDLR APOA2 APOC3 METAPATHWAY BIOTRANSFORMATION PHASE I AND II%WIKIPATHWAYS_20260610%WP702%HOMO SAPIENS Metapathway biotransformation Phase I and II CYP46A1 CHST14 CHST3 GPX2 CYP21A2 GPX3 CYP11A1 GSTT2 CYP51A1 HS3ST3A1 HS6ST1 HS6ST2 HEL-S-166mP HS2ST1 HS6ST3 CHST12 NDST3 CHST13 HS3ST3B1 CHST7 SULT1E1 HS3ST1 HS3ST2 AKR1D1 EPHX2 BAAT CYP8B1 UGT1A10 GSTM2 MGST3 HEL-S-64p MGST2 UGT2B11 UGT2B15 UGT2B17 UGT2B28 HEL-S-75p UGT1A5 UGT2B4 GSTM5 CYP26B1 UGT2A2 UGT2A1 UGT2B7 SULT2B1 CYP26A1 MGST1 CYP7A1 GSTZ1 HEL-S-21 HEL-S-75 Em:AP000351.3 GSTA5 CHST10 CYP4F2 GSTA4 NAA50 GSTA3 CYP2C18 GATF-C GLYATL2 GPX4 AKR1B10 GSTM1 NAT8 NAT2 CYP2A13 NAT9 NAA40 NAT10 NAT14 AKR1B1 LOC51064 GAL3ST2 GAL3ST3 GAL3ST4 CHST8 CHST9 UGT1A1 KCNAB1 KCNAB3 GSTM4 CHST4 NAT8L CHST5 NAA20 HS3ST5 HS3ST6 CYP2C19 FMO4 CYP4F12 CYP17A1 HS3ST4 CYP2C9 FMO5 CYP27A1 CYP2R1 CYP2A6 CYP2B6 CYP3A43 SULT2A1 HYAL3 CYP26C1 UGT1A4 UGT1A3 UGT1A9 CHST6 UGT1A7 NNMT INMT SULT1A1 CHST1 CYP4F3 HEL-75 SULT1C3 SULT1B1 SULT1C2 SULT6B1 SULT1A4 SULT1A2 CYP1A2 SULT1C4 HEL-S-165mP AKR1C1 EPHX1 CYP1A1 CYP1B1 AKR1C2 AKR1C4 CYP3A4 CYP2E1 CHST11 CYP27B1 CYP24A1 CYP11B2 TPMT GSTM3 CYP2S1 HEL-S-22 CYP4Z1 CYP3A7 CYP4V2 CYP7B1 CYP2A7 CYP2U1 CYP4F22 CYP4X1 CYP2F1 CYP2J2 CYP4F11 CYP4F8 CYP2W1 CYP27C1 CYP20A1 ANGIOTENSIN II RECEPTOR TYPE 1 PATHWAY%WIKIPATHWAYS_20260610%WP5036%HOMO SAPIENS Angiotensin II receptor type 1 pathway PTPN11 IL6ST PDGFD TGFBR2 ACTA2 IL11RA SP1 ACE2 COL1A1 COL1A2 TGFB1 CTGF AGTR1 MAPK1 TGFBR1 IL11 NOX4 JUND SMAD4 RAF1 HIF1A MAP2K6 MAS1 RRAS COMPLEMENT SYSTEM%WIKIPATHWAYS_20260610%WP2806%HOMO SAPIENS Complement system C4BPA ELANE C3AR1 CR1 TXN SELL CD46 CSNK1A1 F13A1 SELPLG CPN1 FCGR3A VSIG4 ITGA2 CD93 CFH HEL-S-92n C5AR2 FCER2 CFI SELE FKBP2 C5AR1 FPR1 F11 RPS19 CFHR2 DKFZp686L0365 CD59 CFHR4 PTX3 SFTPA1 CRP ITGA2B IBSP GNAI3 CR2 HEL-S-99n GNA15 HEL-S-62p PLAUR WAS VTN F10 PRKCA THBS1 CLEC4M C4A ICAM2 FGA opn LAMC1 SELP PLG CD40 HEL-S-78p ALB ADM SFTPA2 LAMA5 CD19 CFD C1S CFP C8A LAMB1 C6 DCN C7 C9 MASP2 ITGB3 MASP1 C1QBP CFB CD55 FCN1 MBL2 FCN2 SERPING1 KLKB1 PROS1 PRNP CAFFEINE IN BLOOD VESSELS%WIKIPATHWAYS_20260610%WP5601%HOMO SAPIENS Caffeine in blood vessels PDE4B PDE4A GUCY1A2 PDE4D ADRA1A ADCY3 ADRA1D ADCY1 ADRA1B MYLK PDE3A PDE3B ADCY8 ADCY6 CALM1 ADCY5 HEL-S-80p ADCY9 RYR2 ADORA2A ADORA2B RYR3 PPP1R12C PERTURBATIONS TO HOST CELL AUTOPHAGY INDUCED BY SARS COV 2 PROTEINS%WIKIPATHWAYS_20260610%WP4936%HOMO SAPIENS Perturbations to host cell autophagy induced by SARS CoV 2 proteins ATG3 RAB7A ATG12 SQSTM1 DKFZp686F0183 DEPTOR ATG16L1 TMEM59 DKFZp762B153 VPS39 ATG9A VPS41 ATG2B VPS18 AKT1S1 RB1CC1 GABARAPL2 LAMTOR1 VPS33A MLST8 RPS6 ULK1 OPTN PPP1R9A VAMP8 MTOR APOB VPS16 RHEB PRKAA2 NBR1 LAMP2 RPTOR LARP1 CALCOCO2 HEL-S-30 EIF4B RPS6KB1 BLOOD BASED NEUROINFLAMMATION MARKERS %WIKIPATHWAYS_20260610%WP5548%HOMO SAPIENS Blood based neuroinflammation markers CRP CCL11 CHI3L1 PBR IL6 NEFL CCL23 IL1B CX3CL1 GFAP DBI CCL5 OLR1 BDNF TREM1 CCL2 ADM TNF GRN S100B CYTOKINES AND INFLAMMATORY RESPONSE%WIKIPATHWAYS_20260610%WP530%HOMO SAPIENS Cytokines and inflammatory response IFNB1 IL5 IL7 CSF3 PDGFA IL6 IL10 IL12B IL2 IL4 IL1B TGFB1 IL13 HLA-DRB1 CSF2 CSF1 IL11 IL3 CXCL1 IL1A CXCL2 IFNG TNF MONOAMINE TRANSPORT AND REGULATION%WIKIPATHWAYS_20260610%WP727%HOMO SAPIENS Monoamine transport and regulation TNFRSF11B TGFB1I1 TDO2 SLC6A3 DBH IL1B TH TSC2 SLC5A7 SYN1 TPH2 TNF AMPH HRH3 MAPK14 NECTIN2 SLC6A2 FBXO32 UNC13B RBL2 ACHE STX1A IL1R1 ITGB3 ADORA2A NUCLEOSOME REMODELING COMPLEX%WIKIPATHWAYS_20260610%WP5572%HOMO SAPIENS Nucleosome remodeling complex SUPT16H SSRP1 ASF1A NASP HAT1 CHAF1B ASF1B CHAF1A CHEK2 PCNA H4C9 XRCC5 MCM2 HIST1H4L RBBP4 PRKDC SMIM40 MINERALOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260610%WP5279%HOMO SAPIENS Mineralocorticoid biosynthesis AKR1C1 UGT2B7 HSD11B1 HSD11B2 AKR1C2 SRD5A2 AKR1C4 CYP11B2 AKR1D1 CYP21A2 UGT1A10 PROLACTIN SIGNALING%WIKIPATHWAYS_20260610%WP2037%HOMO SAPIENS Prolactin signaling PIK3CA SOS1 HEL-S-93 AGAP2 FLNA ITGB1 PRLR MAPK8 YWHAG PAK1 MAPK1 MAPK3 STAT1 STAT3 PTPN11 MAPK14 MTOR HEL-S-69p IRS1 NEK3 RELA GAB2 VAV1 STAT5B ZAP70 CBL SOCS3 SOCS1 SRC FYN RPS6KB1 PTPN6 RPS6KA2 SIRPA ERBB2 HEL-S-130P MYC MAP2K1 GSK3B MAP2K2 SHC1 PIK3R2 NFKBIB PIK3R1 NFKB1 RPS6 RAF1 PPIB PXN EIF4EBP1 JUN TEC MAPK9 NFKBIA GRB2 PTPN1 PRL CASP3 HRAS CISH JAK1 RAC1 VAV2 FOS SOCS2 MONOAMINE GPCRS%WIKIPATHWAYS_20260610%WP58%HOMO SAPIENS Monoamine GPCRs HTR1A CHRM1 HTR2A ADRA1A HTR4 HTR6 CHRM2 HTR7 ADRB3 DRD2 DRD1 HTR1E HTR1F HTR1D HTR1B ADRA1D ADRB1 HTR2B ADRA1B ADRB2 HRH1 HRH2 DRD5 ADRA2C HTR5A ADRA2B CHRM3 ADRA2A CHRM4 CHRM5 DRD3 DRD4 PCSK9 MEDIATED LDL RECEPTOR DEGRADATION%WIKIPATHWAYS_20260610%WP2846%HOMO SAPIENS PCSK9 mediated LDL receptor degradation LDLR PCSK9 FACT COMPLEX AND DNA DOUBLE STRAND BREAK REPAIR%WIKIPATHWAYS_20260610%WP5564%HOMO SAPIENS FACT complex and DNA double strand break repair SUPT16H SSRP1 NASP RNF8 RNF168 RAD51 H1-1 ATM TP53BP1 H4C9 XRCC5 HIST1H4L NBN SETD2 MDC1 PRKDC NCRNAS IN WNT SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260610%WP4336%HOMO SAPIENS ncRNAs in Wnt signaling in hepatocellular carcinoma KREMEN1 ELAVL1 KLF4 WIF1 CSNK1A1 RYK NOTUM CTBP2 ROR1 ROR2 APC DVL3 PORCN CHD8 SOST SENP2 LEF1 WNT3A MTDH CXXC4 TCF7L2 TCF7L1 hCG_2014051 CSNK1A1L NLK FOSL1 EZH2 CSNK2A1 CCND1 MYC GSK3B CTNNBIP1 WNT2B FZD10 SOX7 WNT5B CCND3 CCND2 WNT16 FZD7 AXIN1 FZD8 WNT3 SFRP4 WNT4 DVL2 WNT10B WNT10A FZD3 FZD5 WNT7B FZD9 WNT7A JUN FRAT1 CTBP1 FRAT2 NKD1 NKD2 SOX17 LRP5 CER1 CSNK2A3 CSNK2A2 LRP6 DKK1 DKK2 DKK4 SFRP1 SFRP5 DVL1 FZD1 CSNK2B WNT1 FZD2 AFFECTED PATHWAYS IN DUCHENNE MUSCULAR DYSTROPHY%WIKIPATHWAYS_20260610%WP5356%HOMO SAPIENS Affected pathways in Duchenne muscular dystrophy ELANE TGFBR2 CASQ1 IL1B PRKAA1 RYR1 CAMK2D SSPN MPO TRPC1 TNF MCU IL10 ATP2A1 CTGF SLN MCUB SCX CACNB1 SGCA TRDN STIM1 PRG3 SNTB1 FKBP1A SMAD4 CACNA1F MMP9 CACNA1S IL6 MMP2 CYBB FGA ITPR2 TOMM20 opn TGFBR1 NFKB1 NOX4 TNNI1 DMD HEL-S-78p PPIF CACNG1 ORAI1 DAG1 SMAD2 NOS2 PRKAA2 CAPN3 NFKBIA TGFB1 AGTR1 SLC25A5 CACNA2D1 CASP9 IL1A TRPC6 TRPC3 PLA2G2A ZINC HOMEOSTASIS%WIKIPATHWAYS_20260610%WP3529%HOMO SAPIENS Zinc homeostasis SLC30A1 MT1B MT1E SLC39A9 SLC39A6 SLC39A5 SLC39A8 SLC39A11 SLC39A10 SLC39A13 SLC39A12 SLC39A14 SLC39A2 SLC39A1 SLC39A3 MT1M MT4 SLC30A10 MT3 SLC30A7 SLC30A6 SLC30A9 MT1A SLC30A8 SLC30A2 MTF1 SLC30A5 MT1F SLC30A4 MT1G VITAMIN B12 METABOLISM%WIKIPATHWAYS_20260610%WP1533%HOMO SAPIENS Vitamin B12 metabolism MCEE CTH MTR HEL-S-51e CBLIF IL6 PLAT CUBN CBS TCN2 TCN1 IL1B SERPINA3 HEL-S-44 FGA INSR NFKB1 F7 SAA4 NFKB2 PLG HEL-S-78p ALB MPO SAA1 TNF SAA2 CRP SCARB1 APOB MTRR HBB LDLR HBA2 ABCA1 INS RELA MAT1A CCL5 APOE F2 CCL2 IFNG KYNURENINE PATHWAY AND LINKS TO CELL SENESCENCE%WIKIPATHWAYS_20260610%WP5044%HOMO SAPIENS Kynurenine pathway and links to cell senescence IFNB1 EIF2AK1 EIF2AK4 HAAO TDO2 AFMID IL1R2 AHR IDO2 KYNU CDKN1A FOXO1 TLR4 KMO KLF5 AADAT IFNG TNF HEL-S-90n IDO1 APOPTOSIS MODULATION AND SIGNALING%WIKIPATHWAYS_20260610%WP1772%HOMO SAPIENS Apoptosis modulation and signaling AIFM1 MYD88 CASP2 BOK HRK BIRC7 CASP4 MAPK8 CRADD BCL2L2 BNIP3 HTRA2 TRADD MAPK3 BAD CDKN2A IKBKB MADD BAX BCL2L11 PRKD1 BCL2A1 IL1R2 TRAF3 TRAF6 SEPTIN4 BLK RIPK1 FADD BCL2L1 MCL1 DIABLO TNFRSF6B AIFM2 PTRH2 BAG3 BMF PTPN13 MAP3K5 TNFRSF10C TNFRSF10A BBC3 BIK PIDD1 BIRC5 NFKB1 NAIP MAP3K14 APAF1 TNFRSF1B TNFRSF25 BIRC2 BIRC3 JUN PMAIP1 BCL2L10 TNFRSF10B BCL2 CASP6 NFKBIA CASP10 BAK1 CYCS TNFSF10 IL1R1 DFFB CASP9 DFFA CASP8 CASP3 IRAK1 TNFSF6 TNFRSF10D SMIM40 FOS TNFRSF1A MALATE ASPARTATE SHUTTLE%WIKIPATHWAYS_20260610%WP4315%HOMO SAPIENS Malate aspartate shuttle GOT2 SLC1A3 SLC25A11 HEL-S-32 INTERACTIONS BETWEEN IMMUNE CELLS AND MICRORNAS IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260610%WP4559%HOMO SAPIENS Interactions between immune cells and microRNAs in tumor microenvironment IL2RA IL2RB TGFBR2 IRAK4 TLR8 IL4 TRAF6 TGFB1 TLR7 PDCD1 TLR4 NFKB1 NFKB2 SOCS1 CCL5 CD80 CCL2 STAT3 IL2RG CTLA4 NUCLEAR RECEPTORS%WIKIPATHWAYS_20260610%WP170%HOMO SAPIENS Nuclear receptors RARB NR1i1 NR3C1 NR1I3 NR2E1 RORA NR0B1 NR1i2 NR2F2 NR5A2 NR2F6 RXRA NR1H2 NR3A2 NR1D2 NR5A1 PPARG ROR1 THRA NR1C2 PGR NR2C2 RXRB RXRG ESRRA NR1A2 NR2F1 ESRRB HNF4A NR1H3 NR1B3 NR1C1 RORC RARA EXRNA MECHANISM OF ACTION AND BIOGENESIS%WIKIPATHWAYS_20260610%WP2805%HOMO SAPIENS exRNA mechanism of action and biogenesis DGCR8 DROSHA DICER1 AGO2 ERI1 XPO5 NEPHROTIC SYNDROME%WIKIPATHWAYS_20260610%WP4758%HOMO SAPIENS Nephrotic syndrome ALG1 HEL-S-47e CUBN PTPRO GPC5 COL4A3 APOL1 COL4A5 ITGB4 SYNPO YARS ARHGAP24 CD2AP INF2 E2F3 WDR73 NPHS1 LMX1B NPHS2 CYP11B2 WT1 COQ8B SMARCAL1 CD151 EMP2 CTLA4 PLCE1 COQ2 MYO1E ACTN4 MYH9 COQ6 ZMPSTE24 LAMB2 LMNA PAX2 COL4A4 SCARB2 TRPC6 NF1 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260610%WP5366%HOMO SAPIENS NF1 copy number variation syndrome SOS1 TUBB SUPT5H ARHA MAPK1 MAPK3 EGFR ARF6 SDC2 CCNA2 H3C15 H3C8 H4C9 USP1 JARID2 EED HIST1H4L LIMK1 NGF HOXA1 PER1 MAP3K1 EZH1 MCL1 IFNB1 RFC2 CRY1 MAVS RFC3 RFC4 EGF MYT1 HEL-S-15 RIGI NF1 OMG PCNA RTN4R SYN1 RBBP7 RAF1 WDR48 EXOC8 HOXA9 EVL CCNE2 INPP5A E2F6 RAB11FIP4 CCNE1 TEFM UTP6 ATAD5 COPRS EXOC7 RAB11A EVI2A ROCK2 CENTA2 CRLF3 SUZ12 EVI2B EXOC4 EIF3A EXOC3 METAP2 EXOC6 BCL2 EXOC5 RAD51 EXOC2 ATR POLRMT MAP3K2 RAD9A EXOC1 NGFR OXYSTEROLS DERIVED FROM CHOLESTEROL%WIKIPATHWAYS_20260610%WP4545%HOMO SAPIENS Oxysterols derived from cholesterol EPHX2 AKR1C4 CYP3A4 CYP46A1 BAAT CYP8B1 NR1i2 DHCR7 SLC27A5 LBP CYP27A1 NR1H2 NR3A2 SULT2A1 INSIG1 ACOT9 ACOT8 ACOT7 ACOT11 ACOT12 ACOT13 SLC27A2 EBP CYP7B1 SULT2B1 AMACR DBP THEM5 ACOT6 IL25 CYP7A1 HSD3B7 ACOT4 CH25H GPR183 IL17F IL17D IL17C IL17B IL17A HSD11B1 HSD11B2 AKR1D1 RORC VITAMIN K METABOLISM AND ACTIVATION OF DEPENDENT PROTEINS%WIKIPATHWAYS_20260610%WP5186%HOMO SAPIENS Vitamin K metabolism and activation of dependent proteins F10 PROC UBIAD1 NQO1 F7 AIFM2 F2 F9 VKORC1 GGCX PROS1 PROZ RNA POLYMERASE II TRANSCRIPTION THE PREINITIATION COMPLEX%WIKIPATHWAYS_20260610%WP5563%HOMO SAPIENS RNA polymerase II transcription the preinitiation complex TBP MED25 MED24 MED21 GTF2A1 TAF9 MED15 GTF2E2 MED30 NELFA MED31 NELFE POLR2M TAF12 TAF10 TAF11 TRFP TAF7 TAF6 CRSP9 TAF4 IXL TAF3 TAF1 MED9 CTDP1 NELFCD POLR2A POLR2B CDK8 POLR2C POLR2D POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POLR2F MED1 CCNC MED14 TAF5 THRA NELFB GTF2B MED19 MED16 MED18 MED17 MED12 MED11 MED13 MED10 MED8 MED4 MED23 GTF2F1 TAF13 MED26 TAF8 MED27 MED6 MED28 MED22 HIPK2 IN KIDNEY FIBROSIS%WIKIPATHWAYS_20260610%WP4751%HOMO SAPIENS HIPK2 in kidney fibrosis HIPK2 SIAH1 SODIUM CHANNEL IN EPILEPSY%WIKIPATHWAYS_20260610%WP5598%HOMO SAPIENS Sodium channel in epilepsy CAMK2A BACE1 PSEN1 GSK3B SCN1A NEDD4 PTPRN SCN11A SCN3A WEE1 PDCD10 SCN1B SCN9A SCN2B SCN7A SCN10A SCNM1 SCN4A RNF121 TNF FGF14 PRRT2 SCN3B SCN8A FGF13 SCN2A SCN4B FGF12 MAPK8IP2 CALM1 SCN5A FYN VEGFA VEGFR2 SIGNALING%WIKIPATHWAYS_20260610%WP3888%HOMO SAPIENS VEGFA VEGFR2 signaling HEL-S-87p TUBA1C PLCB3 EGR1 FHL2 PSMD4 MYL2 TXN CREB1 RPS6KA5 MAPKAPK2 ITGB1 PSMD11 SELE CXCL8 DKFZp686L0365 SET TPP1 ERN1 GPX1 ENG FUT1 SARS1 PRKD1 hEMMPRIN ATP6V1E1 RAB4A HEL-S-99n MAPKAPK5 DNAJB9 PRKD2 CCL2 FADD BCL2L1 OCRL EZR ITCH MAP3K5 NRP2 EIF4G1 SHC2 SHC1 MMP10 VPS39 MMP14 CAMKK2 MEF2C ATF2 RPS6 ATF4 EPHA2 MYH9 PRKAA2 FARSB MAPK9 NFKBIA RAB5A CLTC PTPN1 CACNA2D1 MAPK12 IGFBP7 ITGB3 DKK1 ITGAV RAC1 VAV2 TEAD4 CDC42 MOV10 FLNB CTNNA1 ARHA ARF4 BRD4 IQGAP1 GPC1 HEL114 PTMA ACKR3 EPRS1 DECR1 PRKCB SIAH2 PPP3CA SLC25A11 DUSP5 CYBB TNFRSF10C GSK3B MAPKAP1 PABPC1 PIK3R2 FOXO4 PIK3R1 FOXO1 tal-1 BMP10 GRB10 MLST8 FOXO3A HBD NCL ACOT9 TNFRSF25 ROCK1 ROCK2 HEL164 CTNND1 TBCA P4HA2 XB TRAF3IP2 PRKG1 HDAC7 HDAC1 CSK WASF1 CYR61 RCAN1 RPL5 FXR2 HEL2 DLL4 ELOC RPL13a CALU RPL10A RPL7 PRKAA1 NAPA RPL18A RPLP2 LUC7L UBAP2L CHAC1 RPS11 ARF6 IER5 ACACB TMEM170A ACACA ABCF2 SND1 PLA2G5 KATNAL2 EWSR1 BIN1 ATP6V0D1 GIGYF2 HMGB1 DHX36 MYO6 MICAL2 PRRC2C LARP7 MAP2K3 HEL-S-162eP SRPK1 RPL27 DHX29 RPL26 KCNC3 CTGF CCDC124 SRP54 EEA1 ELOA CLIC1 NUMB CGNL1 CBL SSR4 SSR3 FJX1 KANK1 PLAUR FYN CRIP2 EIF4E SLC7A1 SDCBP APOLD1 MAP2K6 FGD5 COPG1 FBXW11 PLOD3 RPS6KB1 LMAN1 CCRL2 MYO1C TMSB10 PTPN6 HEL107 NCF1 SEMA6D NCF2 DOK1 ARMCX1 RAB37 HEL-S-133P FRS2 ZNF555 DSC1 HEL-S-68p CCND1 LRRC59 HTRA1 HEL-S-15 GLUD1 ZC3H15 AP2A1 HEL-S-94n MAP2K1 HEL-S-84 AFDN MAP2K2 TFCP2 NR4A3 SPIRE1 GRSF1 SHB C15orf39 NCK1 FGA HGS NRARP LDB2 RND1 CAPZB BMX LRRFIP2 ERG ADAMTS9 RAF1 ARHGEF15 HEL-S-78p SHROOM2 ALB EIF3S3 MMRN2 HEL-S-128m PXN PPM1G HLX RAP1A DNAJB4 FAM120A PPP2CA SLC25A25 PDE4DIP PRKCE JUN CDC42BPB RAB11A FMNL3 PTPN9 EIF3F SLC2A14 EIF3D BCL2 MDM2 GRB2 CYCS EPHB2 HRAS CCT7 AMOT TRPC3 INPP4B HDAC5 NOTCH4 HBEGF TAOK2 PIK3CA RAPGEF1 CRK HEL-S-2a TXNIP F3 FHOD1 MAPK8 PAK1 AKT1S1 MAPK1 PTK2B RICTOR MAPK3 STAT1 SYNJ1 TRPC1 FLII STAT3 PTPN11 MAPK14 MTOR S1PR1 GJA1 SDF2L1 TMSB4X ADRB2 HYOU1 RELA EIF2A SH2D2A CSRP2 EPN1 ADAM10 CREBBP AP2S1 FLT1 LIMK1 SRC VEGFA KDR PLCG1 MAP2K4 ADAM9 CNP PRKCI NFATC2 NFATC1 PDPK1 PRKCA DPM1 PRKCZ PFN1 SLC8A1 MMP2 KL BIRC5 NFKB1 NOX4 ANXA1 QK3 TMOD1 GATA2 TPM3 AAG1 PNP FAF1 ACTG1 HEL-S-102 TFAM BMP2 PTGS2 TUBB8 13Q12 12 COPY NUMBER VARIATION%WIKIPATHWAYS_20260610%WP5406%HOMO SAPIENS 13q12 12 copy number variation CDC42 ARHA RTN4R MAPK8 SSPN LINGO1 DMD TNFRSF19 TRAF1 MIPEP DAG1 SACS RTN4 C1QTNF9 ATXN1 TRAF2 SGCD SGCB SGCG MAPK9 C1QTNF9B TRAF3 SPATA13 TRAF5 SGCA SNTA1 SNTB1 RAC1 NANOPARTICLE TRIGGERED AUTOPHAGIC CELL DEATH%WIKIPATHWAYS_20260610%WP2509%HOMO SAPIENS Nanoparticle triggered autophagic cell death AMBRA1 ATG3 ATG10 CHAF1A ATG12 DKFZp686F0183 INS ATG16L1 BCL2 ULK2 VMP1 ATG14 TSC2 TSC1 SH3GLB1 INSR UVRAG ATG9B ULK1 MAP1LC3A TYROBP CAUSAL NETWORK IN MICROGLIA%WIKIPATHWAYS_20260610%WP3945%HOMO SAPIENS TYROBP causal network in microglia TYROBP NPC2 SAMSN1 CYTL1 GAL3ST4 NCKAP1L ITGAX LHFPL2 GAPT MAF LYL1 DPYD HCLS1 ITGAM GPX1 SLC7A7 IL10RA HEL-S-62p CXCL16 PLEK NCF2 RPS6KA1 ZFP36L2 SH2B3 RGS1 PYCARD IL13RA1 opn RUNX3 TGFBR1 HEL-S-66 TNFRSF1B HLX CREB3L2 CENTA2 NRROS CD84 FKBP15 LOXL3 GIMAP2 TCIRG1 PPP1R18 CD37 RNASE6 IL18 LGALS9C APBB1IP BIN2 C1QC ELF4 SFT2D2 RBM47 IGSF6 KCNE3 NSP1 FROM SARS COV 2 INHIBITS TRANSLATION INITIATION IN THE HOST CELL%WIKIPATHWAYS_20260610%WP5027%HOMO SAPIENS nsp1 from SARS CoV 2 inhibits translation initiation in the host cell EIF1AX SUI1 EIF3F EIF5 EIF3D EIF2S3 EIF3A EIF3S2 EIF3J EIF3G EIF2S2 EIF2S1 EIF3CL EIF3E EIF3B EIF3S3 CORI CYCLE%WIKIPATHWAYS_20260610%WP1946%HOMO SAPIENS Cori cycle HEL-S-87p SLC2A2 PGAM1 PFKP HEL-S-133P SLC2A4 HEL-S-68p GPT INS HEL-S-162eP HEL-S-49 SEROTONIN RECEPTOR 2 AND ELK SRF GATA4 SIGNALING%WIKIPATHWAYS_20260610%WP732%HOMO SAPIENS Serotonin receptor 2 and ELK SRF GATA4 signaling RASGRF1 NRAS MAPK1 HTR2A MAPK3 RAF1 HTR2B HRAS MAP2K1 MAPKAPK2 MAP2K2 GATA4 NON CLASSICAL ROLE OF VITAMIN D%WIKIPATHWAYS_20260610%WP5133%HOMO SAPIENS Non classical role of vitamin D AGTR1 CYP2R1 AGTR2 CYP27B1 ACE2 REN QUERCETIN AND NF KB AP 1 INDUCED APOPTOSIS%WIKIPATHWAYS_20260610%WP2435%HOMO SAPIENS Quercetin and Nf kB AP 1 induced apoptosis JUN KEAP1 COX1 NFKBIA MAFG MAFK CYP2A6 NFE2L2 NFKB1 PTGS2 VEGFA IKBKB FOS DNA REPLICATION%WIKIPATHWAYS_20260610%WP466%HOMO SAPIENS DNA replication MCM7 UBC RFC2 ORC1L MCM10 POLE CDC6 RFC3 RFC4 PCNA RPA4 CDC45 CDT1 RPA1 PRIM2 RFC1 RPA3 PRIM1 GMNN POLD3 POLD4 POLD2 MCM3 CDK2 MCM5 MCM6 POLA1 MCM2 POLA2 ORC6 POLE2 ORC3 ORC2 DBF4 EFFECT OF PROGERIN ON GENES INVOLVED IN PROGERIA%WIKIPATHWAYS_20260610%WP4320%HOMO SAPIENS Effect of progerin on genes involved in progeria SUV39H1 MTA2 RB1 CHD4 H3C15 CBX3 KDM1A HEL25 MTA3 LEF1 H3C8 MBD2 CBX1 H3F3B MBD3 HDAC2 RBBP7 RBBP4 HDAC1 CHD3 TGFB SMAD SIGNALING%WIKIPATHWAYS_20260610%WP5382%HOMO SAPIENS TGFB Smad signaling YWHAG SMAD2 WWTR1 TGFBR2 TGFBR1 SPARC SMAD4 TGFBR3 POSTN CTGF WNT BETA CATENIN SIGNALING IN LEUKEMIA%WIKIPATHWAYS_20260610%WP3658%HOMO SAPIENS Wnt beta catenin signaling in leukemia SALL4 AXIN2 CCND1 PML PYGO1 MYC CSNK1A1 LEF1 WIF1 GSK3B BCL9 TCF3 RUNX1T1 LRP5 JUP ZBTB16 LRP6 DKK1 FLT3 APC NR1C2 WNT1 RARA MRNA PROCESSING%WIKIPATHWAYS_20260610%WP411%HOMO SAPIENS mRNA processing SFPQ PRPF40A SNRPB2 PTBP1 POLR2A SRPK1 PRMT1 SRP54 CLK2 PRMT2 HNRNPAB YBX1 HNRNPH1 HNRNPL SMC1A PPM1G DICER1 FUS RNMT SUPT5H CD2BP2 HNRNPR CLP1 SNRPD2 PAPOLA SNRPD1 TXNL4A PSKH1 METTL3 SNRPD3 PRP4K CDC40 PRPF4 PRPF6 PRPF3 SNRPG SRSF4 DHX15 SREK1 SNRPE SRSF6 SRSF7 SNRPF SNRPA SNRPB DHX8 DDX1 CSTF3 CSTF2 PRPF8 SFRS5 SFRS8 CSTF1 DHX38 WDR57 SRPK2 CPSF4 SNRPN CPSF1 CPSF3 NONO CPSF2 SFRS3 DHX16 CLK4 LSM2 CLK1 LSM7 HNRNPD SRSF10 RNPS1 CLASRP HNRNPC SNRPA1 DKFZp434N041 SUGP2 SF3B5 SUGP1 SF3B2 CELF2 CELF4 RBM5 RBM17 PRPF18 NHP2L1 DNAJC8 SF3A1 CSTF2T SF3A2 U2AF1 PABPN1 U2AF2 PHF5A TRA2B SPOP NUDT21 HNRNPA2B1 RBMX SRSF9 TMED10 CELF1 NCBP1 NCBP2 COMPLEMENT MEDIATED INFLAMMATION OF PULMONARY ALVEOLUS IN COVID 19 HYPOTHETICAL PATHWAY %WIKIPATHWAYS_20260610%WP5148%HOMO SAPIENS Complement mediated inflammation of pulmonary alveolus in COVID 19 hypothetical pathway C8A C6 C7 HEL-S-62p C3AR1 C9 C5AR1 MASP2 ACE2 COLEC11 FCN1 15Q13 3 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260610%WP4942%HOMO SAPIENS 15q13 3 copy number variation syndrome KAT2B GOLGA8R FAN1 ARHGAP11B KLF13 OTUD7A GPR75 GOLGA8O GOLGA8Q MTMR10 TRPM1 GOLGA8H GRM6 CHRFAM7A CREBBP CCL5 FYN CHRNA7 FANCD2 NUCLEOTIDE METABOLISM%WIKIPATHWAYS_20260610%WP404%HOMO SAPIENS Nucleotide metabolism SRM IMPDH1 NME2 ADSS RRM1 RRM2 DHFR POLA1 MTHFD2 OAZ1 POLG ADSL RRM2B DISORDERS OF GALACTOSE METABOLISM %WIKIPATHWAYS_20260610%WP5173%HOMO SAPIENS Disorders of galactose metabolism AKR1B1 SLC2A2 GYS2 HEL-S-19 SLC5A1 GYG1 GYS1 PYGL MAMMARY GLAND DEVELOPMENT PUBERTY STAGE 2 OF 4%WIKIPATHWAYS_20260610%WP2814%HOMO SAPIENS Mammary gland development puberty stage 2 of 4 AREG CCND1 EGF ERBB2 MYC FOSL1 PGR HEL113 TIMP1 MECP2 AND ASSOCIATED RETT SYNDROME%WIKIPATHWAYS_20260610%WP3584%HOMO SAPIENS MECP2 and associated Rett syndrome CAMK2A OPRK1 FOXG1 FGF3 REST FGF4 SST CREB1 SIN3A TAF1 TET2 NCOR1 MBP MTOR APOC2 BCL6 TET1 HEL-S-20 FGF2 DLX5 GRIA3 IGF1R GRIA4 EZH2 CNP MYT1 NF1 FUT8 YBX1 IGF1 POU3F2 HNRNPH1 CEBPD MEF2C RPS6 PSIP1 FKBP5 CDON UBE3A RBFOX1 TET3 DLX6 NREP PRPF38A POU4F1 HNRNPF IGF2 SP1 SP3 GAD1 FUS PTEN GRIN1 SGK1 CTCF SMC3 GPRIN1 BDNF TARDBP HDAC1 MARKERS OF KIDNEY CELL LINEAGE%WIKIPATHWAYS_20260610%WP5236%HOMO SAPIENS Markers of kidney cell lineage PECAM1 NOTCH1 NTN1 EGLN3 EPO EGLN2 AXIN2 FGF7 HNF1A EMX2 WT1 TNC KIT FGF8 NT5E HNF4A SMAD1 KDR LHX1 TCF2 DKFZp781O1323 REN TLX1 NPHS1 NPHS2 WNT4 NOTCH2 CITED1 SIX1 DACT1 ACTA2 KCTD1 DES TSHZ3 PBX1 TBX18 FAT4 VSX2 SALL1 SIX2 EYA1 FOXD1 EGLN1 OSR1 BMP7 TCF21 DCN PAX2 ALDH1A2 RSPO3 RSPO1 BMP4 SFRP1 GDNF OMEGA 3 OMEGA 6 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260610%WP4723%HOMO SAPIENS Omega 3 omega 6 fatty acid synthesis PLA2G5 ACOX1 ELOVL5 ACOX3 FADS1 ELOVL2 PLA2G6 FADS2 ACSL1 FACL4 PLA2G4B ACSL3 MALE INFERTILITY%WIKIPATHWAYS_20260610%WP4673%HOMO SAPIENS Male infertility H2BW1 TMEM132E CLU UBE2B XRCC3 TAS2R38 PUM2 DAZL PIWIL2 PIWIL1 PIWIL4 SPO11 HORMAD2 MSMB SOX5 PACRG TEX15 CXXC1 OR2W3 MAS1L P1 TRIP13 USP26 PEX10 CDC42BPA MLH3 CTCFL SEMG1 BRDT GPX1 TNF EP300 APOB SLC46A1 H4C9 XRCC5 MTHFD1 CDK9 SRD5A2 SIRPA MTR PRMT6 PSAT1 RFC1 CYP26B1 REC8 FAT10 MTRR AHR BCL2 MDM2 PMS2 ATM AHRR CHD2 AGO2 H3-4 NQO1 ABCB1 TCN2 CYP17A1 GNAO1 HMGA1 PEMT HEL-S-61p CREBBP PON2 PON1 BRCA2 MMP9 XPC SHMT1 CYP1A1 THBS1 MMP2 ERCC1 ERCC2 NFE2L2 INSR NR3A2 POLG DND1 KDM3A NOS2 CCNK PRDM9 SIRPG HEL110 EPSTI1 SLC16A7 RAG1 NANOS1 PRM2 PRM3 FOLH1 SPATA17 ETV5 MSH4 MSH5 TSSK4 DDX4 DAZ4 DAZ3 TNFSF6 VCX DAZ2 STRA8 MOV10L1 OVARIAN INFERTILITY%WIKIPATHWAYS_20260610%WP34%HOMO SAPIENS Ovarian infertility TBP FMR1 SMPD1 EGR1 NR1i1 DAZL FSHR SYNE2 CREB1 PRLR TSC2 CEBPB TSC1 CCND2 NR3A2 PTGER2 NR5A1 LHCGR NCOR1 FIGLA DMC1 PGR ZP3 MTOR CDK4 ZP2 RAD51 ATM CDKN1B MSH5 INHA GJA4 COVID 19 THROMBOSIS AND ANTICOAGULATION%WIKIPATHWAYS_20260610%WP4927%HOMO SAPIENS COVID 19 thrombosis and anticoagulation F13B FGA PLG F2 HEL-S-78p F13A1 DOWNREGULATION OF ACE2 BY SARS COV 2 SPIKE PROTEIN%WIKIPATHWAYS_20260610%WP4799%HOMO SAPIENS Downregulation of ACE2 by SARS CoV 2 spike protein AGTR1 AGTR2 ACE2 IDO METABOLIC PATHWAY%WIKIPATHWAYS_20260610%WP5414%HOMO SAPIENS IDO metabolic pathway KYNU GOT2 KMO TDO2 KYAT3 IFNG AADAT KYAT1 IDO2 TNF IDO1 FOCAL ADHESION PI3K AKT MTOR SIGNALING%WIKIPATHWAYS_20260610%WP3932%HOMO SAPIENS Focal adhesion PI3K Akt mTOR signaling DDIT4 CREB1 ITGB1 VEGFB VEGFC ITGA4 ITGA2 ITGB7 GNGT1 PELO HIF3A GNGT2 COL11A2 PFKFB2 PFKFB1 PFKFB4 PIK3IP1 IL6R IFNAR2 IFNAR1 GNG3 GNG10 JAK3 GNG5 GNG4 GNG7 GNG8 GNG12 GNG11 GNG13 IFNB1 IRS4 GNB2 GNB1 FGF16 CRTC2 ATF2 RPS6 TCL1B TCL1A PPP2R1B CREB3L3 PPP2R1A CREB3L4 CREB3L2 KPG_010 CDC37 ATF4 PDGFA EPHA2 LPAR2 LPAR3 PRKAA2 INS IFNA7 GYS2 OSMR ITGB3 PRL PHLPP2 PHLPP1 ITGAV GYS1 OSM CSHL1 KITLG GHB3 CSF3 ITGA6 CSF3R CHRM1 EPO RAB2A FGF3 FGF4 FGF6 FGF7 FGF9 PRLR EFNA5 EFNA4 FGF20 FGF22 FGF21 EGFR FGF17 EFNA1 EFNA3 FGF14 EFNA2 FGF19 FGF18 GNB4 IL7R ITGA2B FGF10 TNC HSP90AB1 FLT4 GHR PPP2R5E PPP2R5B PPP2R5A PPP2R5D COMP PPP2R5C IBSP CREB3 TNR IL3RA CREB5 COL4A2 ATF6B COL4A1 GNG2 COL4A4 PPP2R3C COL4A6 ANGPT4 ANGPT2 PPP2R3A EPOR PPP2R2C PPP2R2B VTN PPP2R2D PDGFD CHAD PDGFC COL1A1 GSK3B COL1A2 PIK3R2 COL5A3 COL5A2 PIK3R1 ITGB4 FOXO1 RAB8A NRAS LAMC2 LAMC1 MLST8 ITGB8 FOXO3A ITGB6 ULK1 ITGAE VWF COL2A1 ITGA7 SLC2A2 SLC2A3 LAMA5 LAMA1 LAMA4 LAMA3 THBS2 THBS4 THBS3 RELN LAMB3 LAMB2 LAMB1 VEGFD XB LPAR4 ITGAX LPAR1 CAB39 STK11 PRKAA1 CSF1 RAB14 ACACA STRADA IRS1 PIK3CD FGF8 IL2 NGF EIF4E EIF4B FGFR4 RPS6KB1 FOXA1 PIK3R4 MAP2K1 MAP2K2 HGF TSC2 TSC1 EIF4E1B RAF1 EIF4EBP1 PPP2CA RHEB FGF13 MDM2 GRB2 FGF12 CDKN1A PIK3R5 CDKN1B PTEN F2R RPTOR CASP9 NGFR HEL-S-125m HRAS JAK1 PIK3CA SOS1 ELAVL1 RAB11B AKT1S1 MAPK1 PPARGC1A MAPK3 ITGAM BAD IKBKB AKT3 IKBKG MTOR LIPE KIT CSF1R PDGFRA FLT1 RPS6KB2 ANGPT1 RAB10 FGF2 HIF1A VEGFA IGF1R KDR PIK3C2B FGFR2 PDPK1 THBS1 EGF CHRM2 FGFR1 IGF1 opn INSR SLC2A4 IL2RG COL3A1 FGFR3 IL2RA IL2RB NOS2 GNB3 MITOCHONDRIAL COMPLEX I ASSEMBLY MODEL OXPHOS SYSTEM%WIKIPATHWAYS_20260610%WP4324%HOMO SAPIENS Mitochondrial complex I assembly model OXPHOS system ACAD9 NDUFAF2 NDUFAF1 NDUFA5 NDUFB11 NDUFA13 NDUFA12 TMEM186 C3orf60 TMEM126B NDUFC2 DMAC1 NDUFC1 DMAC2 TMEM70 NDUFS6 COA1 NDUFS5 NDUFAF6 NDUFS4 NDUFAF4 NDUFS1 ND2 ND5 ND4 NDUFB9 ND6 NDUFB8 NDUFB7 NDUFB6 TIMMDC1 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB10 NDUFB1 ECSIT NDUFV3 NDUFV2 NDUFA10 NDUFA7 NDUFA6 ZNF183 NDUFA3 NDUFA2 ND4L NDUFAB1 NUBPL NDUFS3 ND1 MRNA VACCINE ACTIVATION OF DENDRITIC CELL AND INDUCTION OF IFN 1%WIKIPATHWAYS_20260610%WP5187%HOMO SAPIENS mRNA vaccine activation of dendritic cell and induction of IFN 1 IRF7 TLR7 MAVS TNFRSF11A RIGI IRF3 TLR8 IFIH1 TLR3 MR1 GLYCOLYSIS IN SENESCENCE%WIKIPATHWAYS_20260610%WP5049%HOMO SAPIENS Glycolysis in senescence PRKAA1 HEL-S-133P RB1 HEL-S-68p HEL-S-30 ENO1 HEL-S-162eP 1P36 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260610%WP5345%HOMO SAPIENS 1p36 copy number variation syndrome MRPL20 HES5 IFIT1 ELAVL1 TNFRSF14 B3GALT6 PEX10 SKI CALML6 ARF6 TRIM25 TRAF2 ATAD3A IFIH1 PANK4 TRAF5 INTS11 INTS13 INTS14 PARD6B INTS10 UBE2J2 GDE1 TMEM52 NOC2L COMMD1 METTL14 SDF4 PLEKHN1 SMAD4 CCNL2 SAMD11 MUSK LRP4 ISG15 SSU72 VEGFA PEX2 ATAD3C GLTPD1 VTN ACAP3 CD160 GNB1 RER1 SCNN1D C1QTNF12 TNFRSF4 PEX5 MXRA8 PRKCZ RBX1 VWA1 AURKAIP1 TNLG2B TNLG2A PERM1 AGRN KLHL17 MEPCE GRIK2 PHKG2 PUSL1 TAS1R3 HES4 HEL-S-72p OR4F5 OR4F3 CDK11A CFAP74 MIB2 PEX12 MMP23B RNF223 DKK3 MORN1 TNFRSF18 BTLA TMEM278 FNDC10 ANKRD65 INTS4 INTS9 SLC35E2B C1orf159 SMAD2 NADK PLCH2 TGFB1 MCM2 DVL1 CHRONIC HYPERGLYCEMIA IMPAIRMENT OF NEURON FUNCTION%WIKIPATHWAYS_20260610%WP5283%HOMO SAPIENS Chronic hyperglycemia impairment of neuron function PRKCB PRKCI PRKCH TRPA1 PRKCA TRPV1 PRKCQ PRKCZ MMP21 MMP20 MMP25 MMP2 MMP24 MMP27 MMP28 MMP7 MMP3 MMP10 MMP12 MMP11 MMP14 MMP16 MMP15 SCN9A MMP23B MMP17 SCN10A MMP19 SNAP25 SORD SLC2A3 PRKCE NOS2 PRKD3 SCN8A AGER HEL-S-62p BDNF MMP9 CANNABINOID RECEPTOR SIGNALING%WIKIPATHWAYS_20260610%WP3869%HOMO SAPIENS Cannabinoid receptor signaling MAPK10 FAAH CYP1A1 PRKAR1B PRKAR1A CYP3A4 CYP2C19 CYP2C9 MAPK8 MAPK1 MAPK3 DAGLA CNR1 PRKACG MAPK14 NAPEPLD DAGLB ADCY1 AHR MAPK9 CNR2 MAPK12 MAPK13 MAPK11 ADORA2A CELL LINEAGE MAP FOR NEURONAL DIFFERENTIATION%WIKIPATHWAYS_20260610%WP5417%HOMO SAPIENS Cell lineage map for neuronal differentiation KCNJ6 HES5 NOTCH1 CASK ITGB1 TH HES1 SYP CDH2 PIG59 MSX2 SOX9 SLC1A2 SLC1A3 GLS HOMER1 GRIN2B DLG4 GABBR1 DPPA3 ZFP42 AP2A1 AP2A2 CLDN11 ROBO1 SNAP25 SLC6A5 SLC6A9 TWIST2 RIMS2 HOMER3 SLC6A2 BSN RBFOX3 CACNG2 FBXO15 UNC13A TBR1 LIN7A FUT4 CD24 PCLO ERC1 SLC18A3 SNAI1 DPPA2 SOX17 SNAI2 ERAS GAD1 GLRA1 GLRA2 GLRA3 SLC17A6 SLC17A7 GRIN1 GLRB RIMBP2 NGFR DLG2 NLGN1 PECAM1 CD34 ITGA6 NODAL FGF4 KLF4 OLIG2 SOX10 GABBR2 HOMER2 PAX3 SHANK1 SHANK3 S100B MBP GATA6 TNC LEF1 ADRA2C ADRA2B HTR5A ACHE ADRA2A TBXT HNF4A MAP2 NEF3 FOXA2 CNP MSX1 HTR1A LHX1 MOG GAD2 NEFL AQP4 SLC6A3 SOX2 GATA4 GFAP TWIST1 LMX1B CSPG4 TPH1 TPM1 ChAT GPHN FOXD3 FEV HES3 ESRRB BMP4 MIXL1 POU5F1 METHIONINE DE NOVO AND SALVAGE PATHWAY%WIKIPATHWAYS_20260610%WP3580%HOMO SAPIENS Methionine de novo and salvage pathway MTR MSRA SRM IL4I1 SMS TXN HEL-S-61p MAT1A CHDH MSRB2 MSRB3 AMD1 APIP MRI1 MTAP ADI1 ENOPH1 ACRYLAMIDE BIOTRANSFORMATION AND EXPOSURE BIOMARKERS%WIKIPATHWAYS_20260610%WP4233%HOMO SAPIENS Acrylamide biotransformation and exposure biomarkers CYP2E1 CIRCADIAN RHYTHM GENES%WIKIPATHWAYS_20260610%WP3594%HOMO SAPIENS Circadian rhythm genes MAGED1 MAPK10 HCRTR2 HCRTR1 EGR1 SFPQ DDC HTR7 CREB1 DRD2 ZFHX3 NR2F6 TH PRKAA1 SIN3A SUV39H2 KMT2A TYMS STAR SUV39H1 EP300 MTTP CRTC1 CRX HDAC2 NTRK1 HS3ST2 JUND FBXW11 HOMER1 EZH2 SIX3 RPS27A SKP1 MYBBP1A CLDN4 TOP2A KCNMA1 IL6 NKX2-1 PROX1 SIK1 F7 DRD1 PRKDC NTRK3 GHRL AgRP ATF4 JUN GNA11 CDK4 PRKAA2 PML AHR MAPK9 HDAC3 BTRC PTEN TNFRSF11A NR1H3 DRD3 NGFR DRD4 PHLPP1 DYRK1A NLGN1 C1orf51 NPY2R PROK1 UTS2R HEL-S-2 KCNH7 USP2 CHRM1 SOX14 CARTPT PSPC1 TIMELESS RELB UTS2 OPN4 OPN3 BTBD9 PRF1 SETX NAMPT FBXL3 KDM5A HEBP1 DDX5 RBM4 MAPK8 PROK2 KLF10 KCND2 SFTPC PAX4 MC3R PPARGC1A THRAP3 NFIL3 METTL3 CIPC NR1D1 RBM4B NPS NCOR1 ATOH7 PROKR1 NOCT ARNT2 CAVIN3 PASD1 BMAL2 RAI1 OGT ADCY1 PPP1CC GIG8 NONO PER2 HEL-S-80p hCG_2014051 HNRNPD AANAT MAGEL2 CSNK1D SIRT1 PER1 MTNR1A PER3 MTNR1B UBC CRY2 CRY1 GHRH TCF2 RORA CRH GSK3B CHRNB2 ATF5 CPT1A BHLHE41 RORB SLC9A3 NPAS2 TPH2 NR1D2 LEP PPARG TPH1 UBE3A CREM BHLHB2 ID4 NOS2 ROCK2 DBP ADA GFPT1 ID3 ADORA2A NR1C1 HDAC1 CCAR2 AVP RORC KLF9 EFFECTS OF MFN2 MUTATION%WIKIPATHWAYS_20260610%WP5443%HOMO SAPIENS Effects of MFN2 mutation DYNC1LI2 RHOT1 BAX MFN2 DYNC1I1 RAB7A DCTN1 RAB3B SNCA DYNC2H1 DYNC1H1 TRAK1 ATAT1 KIF1B MAP2 RABAC1 CASP8 SYPL1 CASP3 DYNC2I2 INTERACTOME OF POLYCOMB REPRESSIVE COMPLEX 2 PRC2 %WIKIPATHWAYS_20260610%WP2916%HOMO SAPIENS Interactome of polycomb repressive complex 2 PRC2 MORC3 ELL BCLAF1 STK38 TRIM35 SUZ12 SETX RBBP7 JARID2 EED THRAP3 RBBP4 AEBP2 EZH1 EZH2 SPHINGOLIPID PATHWAY%WIKIPATHWAYS_20260610%WP1422%HOMO SAPIENS Sphingolipid pathway SPHK1 SGMS2 PPP2CA UGCG SGPP2 GBA2 ACER1 KDSR PLPP1 SPTLC2 CERS3 SPTLC3 CERS5 SPTLC1 SERINC1 CERS2 CERS6 CERT1 CERK SGMS1 UGT8 SGPL1 ASAH2 SPHK2 HEMESYNTHESIS DEFECTS AND PORPHYRIAS%WIKIPATHWAYS_20260610%WP5169%HOMO SAPIENS Hemesynthesis defects and porphyrias UROD UROS HMBS CPOX ALAS2 ALAS1 FECH FERROPTOSIS%WIKIPATHWAYS_20260610%WP4313%HOMO SAPIENS Ferroptosis HMOX1 GCLC CBS DKFZp762B153 CP FTL ACSL1 ACSL6 FACL4 ACSL5 ACSL3 ALOX15 COQ2 HMGCR VDAC3 FDFT1 STEAP3 SAT2 CHMP6 CHMP5 SLC3A2 DPP4 FTMT PCBP1 LPCAT3 SLC11A2 AKR1C1 CTH AIFM2 GCLM AKR1C2 DKFZp686F0183 SLC7A11 FTH1 CYBB PHKG2 SLC39A8 SLC38A1 NOX4 HEL-S-64p CISD1 TF TFRC BACH1 POR IREB2 SLC40A1 SLC39A14 HEL-S-102 GPX4 MAP1LC3A MAP1LC3C PRNP UROTENSIN II MEDIATED SIGNALING%WIKIPATHWAYS_20260610%WP5158%HOMO SAPIENS Urotensin II mediated signaling HDAC5 CAMK2A UTS2R HMOX1 UTS2 IL1B VCAM1 ARHA MAPK8 MAPK1 MAPK3 EGFR TNF STAT3 IKBKB PTPN11 MAPK14 CHUK EP300 BAX IRF3 RELA PLN NCF4 TRPC4 DDIT3 CREBBP ALOX5 MMP9 CYBA NCF1 HSPA2 NCF2 AIFM2 IL6 MMP2 GSK3B CYBB COL1A1 PCNA NFKB1 NOX4 GSK3A COL2A1 COL3A1 CCNE1 SMAD2 ACTA2 CDC2 ESPL1 ABCA1 CDK2 BCL2 MAPK9 TGFB1 AGTR1 PTEN NPPB CASP9 NPPA CASP3 NIFEDIPINE ACTIVITY%WIKIPATHWAYS_20260610%WP259%HOMO SAPIENS Nifedipine activity MAPK1 PTK2B CYP3A4 BDKRB2 MAP2K1 PCNA KDR HEL-S-44 CHROMOSOMAL AND MICROSATELLITE INSTABILITY IN COLORECTAL CANCER %WIKIPATHWAYS_20260610%WP4216%HOMO SAPIENS Chromosomal and microsatellite instability in colorectal cancer MAPK10 TGFBR2 NTN1 AXIN2 CSNK1A1 ARHA MAPK8 MAPK1 DCC MAPK3 BAD APC ARAF AKT3 TBK1 BAX BCL2L11 LEF1 TCF7L2 TCF7L1 RALA CSNK1A1L MSH3 SMAD4 REL APC2 CCND1 MYC MAP2K1 GSK3B BBC3 BIRC5 AXIN1 TGFBR1 MSH6 MSH2 RAC3 RAF1 DDB2 POLK SMAD2 JUN PMAIP1 GADD45B GADD45A GADD45G BCL2 MAPK9 TGFB1 BAK1 CYCS EXOC2 CDKN1A CASP9 CASP3 RALB APPL1 PTGS2 RAC1 FOS MIRNA REGULATION OF P53 PATHWAY IN PROSTATE CANCER%WIKIPATHWAYS_20260610%WP3982%HOMO SAPIENS miRNA regulation of p53 pathway in prostate cancer SESN3 PMAIP1 BAX TNFRSF10B CHEK2 MDM2 ATM BBC3 TP53AIP1 PTEN EI24 CASP9 SHISA5 CASP8 ZMAT3 APAF1 CYS1 PERP CASP3 DDB2 SIAH1 DICLOFENAC METABOLIC PATHWAY%WIKIPATHWAYS_20260610%WP2491%HOMO SAPIENS Diclofenac metabolic pathway CYP2B6 CYP2C18 CYP2C19 CYP2C9 MITOCHONDRIAL COMPLEX III ASSEMBLY%WIKIPATHWAYS_20260610%WP4921%HOMO SAPIENS Mitochondrial complex III assembly CYB UQCRC1 UQCRFS1 UQCC UQCRC2 UQCRB UQCR11 UQCR10 UQCRH CYC1 UQCC3 UQCC2 UQCRQ TTC19 LYRM7 SRF AND MIRS IN SMOOTH MUSCLE DIFFERENTIATION AND PROLIFERATION%WIKIPATHWAYS_20260610%WP1991%HOMO SAPIENS SRF and miRs in smooth muscle differentiation and proliferation MEF2B CCND2 CAMK2D MEF2C NKX2-5 MEF2D KLF4 MYOCD WNT SIGNALING IN KIDNEY DISEASE%WIKIPATHWAYS_20260610%WP4150%HOMO SAPIENS Wnt signaling in kidney disease MAPK10 NPHP3 WNT2B ARHA MAPK8 WNT5B INVS WNT9B FZD7 WNT16 FZD8 WNT3 WNT4 DVL2 WNT10B WNT10A DVL3 FZD3 FZD5 FZD4 WNT7B FZD9 WNT7A MAPK9 WNT3A LRP5 LRP6 DVL1 FZD1 WNT1 FZD2 TROP2 REGULATORY SIGNALING%WIKIPATHWAYS_20260610%WP5300%HOMO SAPIENS TROP2 regulatory signaling PECAM1 NOTCH1 PRKCA CLDN7 RB1 ACVRL1 CCND1 PSEN2 CHEK1 ITGB1 IGF1 PIK3R1 NFKB1 EGFR STAT1 CDKN2A CCNE1 JUN BAX MDK IGF2 CDK4 CLDN1 CDK2 BCL2 PAK4 IGF2R CDKN1B PTEN ABCC1 SRC TLN1 IGF1R HEL113 RAC1 TACSTD2 PKC GAMMA CALCIUM SIGNALING IN ATAXIA%WIKIPATHWAYS_20260610%WP4760%HOMO SAPIENS PKC gamma calcium signaling in ataxia CA8 PLCB3 HOMER3 PLCB4 GNA11 PLCB1 PLCB2 ATP2B2 GNA14 GNA15 GRIA2 CACNA1A GRIA3 TRPC3 GRIA4 RYR3 ARACHIDONATE EPOXYGENASE EPOXIDE HYDROLASE%WIKIPATHWAYS_20260610%WP678%HOMO SAPIENS Arachidonate epoxygenase epoxide hydrolase EPHX2 HEL-S-22 COX5A CYP2J2 COX8A CYP2C9 10Q11 21Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260610%WP5352%HOMO SAPIENS 10q11 21q11 23 copy number variation syndrome MYO1C PARG MYBBP1A LRRC18 OGDHL GDF5 CUL5 ARHGAP22 SIRT6 ITCH UVSSA BMPR1A EIF4ENIF1 SMAD9 HSF4 FAM170B CEFIP VSTM4 DKFZp781O1323 DRGX KDM4D C10orf53 ERCC5 RGMB PCNA TMEM273 WDFY4 MAPK8 SMARCC2 NOG ATF2 RIF1 MEN1 ChAT BAZ1B BCL2 HSF1 SLC18A3 ELOA DLD DDX21 SMAD1 JUND SIRT1 BMP2 SMARCA5 NLRP3 DEK AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20260610%WP521%HOMO SAPIENS Amino acid conjugation of benzoic acid GATF-C GLYATL2 ACSS2 4P16 3 COPY NUMBER VARIATION%WIKIPATHWAYS_20260610%WP5365%HOMO SAPIENS 4p16 3 copy number variation PLCG1 SOS1 FRS2 NELFA NELFE NAT8L NSD2 TMEM129 PIK3R1 FAM53A CKAP5 MAPK1 LETM1 NICOL1 TACC3 SLBP MAPK3 ERI1 NELFCD FGFR3 CLTCL1 NELFB GRB2 POLN H3F3B UBE2J2 CBL FGF2 PDGF PATHWAY%WIKIPATHWAYS_20260610%WP2526%HOMO SAPIENS PDGF pathway PLCG1 MAP2K4 WASL SOS1 CDC42 MAP2K1 ARHA SHC1 MAPK8 PAK1 PIK3R1 MAPK1 NFKB1 MAPK3 RAF1 STAT1 STAT3 TIAM1 PTPN11 PDGFA JUN CHUK COX2 NFKBIA GRB2 VAV1 SRC HRAS JAK1 MAP3K1 RAC1 VAV2 FOS BARDET BIEDL SYNDROME%WIKIPATHWAYS_20260610%WP5234%HOMO SAPIENS Bardet Biedl syndrome ARL3 DYNLT2B SUFU DYNC2LI1 PKHD1 NPHP3 IFT80 IFT74 KIF7 LZTFL1 DCDC2 IFT81 INVS TTC8 TMEM107 CNGA1 PTCH1 CEP164 WDR35 BBS2 NEK8 BBS10 EVC BBS1 CLUAP1 BBS12 RP2 TMEM216 FLCN EFHC1 FUZ BBIP1 CNGB1 ZIC2 CRX PKD1L1 ARL13B TMEM67 MKS1 SDCCAG8 RAB23 PDE6D IFT27 USP9X EVC2 PCARE SCLT1 OCRL IFT52 BBS9 CEP41 BBS7 IFT57 TRIM32 TRAF3IP1 CEP290 PKD1 BBS5 BBS4 IQCB1 SCAPER IFT140 IFT43 GLI3 NEK1 EFHC2 DYNC2H1 INPP5E CFAP418 CFAP410 DYNC2I2 GPR161 WDPCP IFT172 SMO CEP104 ARL6 OMEGA 6 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260610%WP5424%HOMO SAPIENS Omega 6 fatty acids in senescence AKR1B1 EPHX2 RB1 FADS2 ELOVL5 FADS1 SLCO2A1 HEL-S-53e GPX1 PTGIS ALOX15 ALOX12 HEL-S-22 ALOX15B PRXL2B PTGES PTGES3 CYP4F8 CDKN1A ALOX5 ELOVL2 MAPK11 ALOX5AP SIRT1 NAT2 DPEP2 LTC4S PTGS2 ALOXE3 HEL-S-298 HPGD PTGS1 DECR1 T CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260610%WP69%HOMO SAPIENS T cell receptor signaling SOS1 CRK CDC42 CREB1 MAPK8 PAK1 MAPK1 PTK2B MAPK3 IKBKB PTPN11 MAPK14 IKBKG CHUK RELA TRAF6 GAB2 VAV1 ZAP70 LCK CBL ITK FYN ICOS GRAP2 WAS PLCG1 REL LCP2 CARD11 NFATC2 PDPK1 NFATC1 CD3G PRKCQ CD3E MAP3K8 BCL10 CRKL CD8A SH2B3 MAP2K1 MAP2K2 LAT SHC1 PIK3R2 NCK1 PIK3R1 NFKB1 MAP3K14 ATF2 HEL-S-81p RAF1 PSTPIP1 VAV3 JUN FYB1 MAPK9 NFKBIA GRB2 MAP3K7 RIPK2 HRAS CD3D MAP4K1 FOS 7Q11 23 DISTAL COPY NUMBER VARIATION%WIKIPATHWAYS_20260610%WP5401%HOMO SAPIENS 7q11 23 distal copy number variation KIF1C MDH2 PTPMT1 SFN RHBDD2 DAPK2 POR ZP2 SRRM3 YWHAG LMNA HEL-S-102 RAF1 TMEM120B TMEM120A SSC4D ZP3 STYXL1 HEL163 ENTEROHEPATIC CIRCULATION OF BILE ACIDS%WIKIPATHWAYS_20260610%WP5396%HOMO SAPIENS Enterohepatic circulation of bile acids SLCO1B1 SLC10A2 ABCC3 SLC51A SLC51B ABCC2 ABCB1 FABP6 ABCB11 17Q12 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260610%WP5287%HOMO SAPIENS 17q12 copy number variation syndrome FBXO47 MLLT6 TMEM132E FBXL20 NEUROD2 MIEN1 ZNHIT3 C17orf78 ASIC2 GAS2L2 HEATR9 TAF15 RASL10B PCGF2 SYNRG EPOP PLXDC1 NLE1 ARHGAP23 HEL-S-6a TBC1D3K STAC2 CDK12 SPMAP1 CCL14 CCL13 CCL11 MRM1 ACACA CCL18 RPL23 CCL15 PNMT CACNB1 MED1 CCL5 CCL4 CCL3 CCL2 CCL4L2 RFFL LHX1 ERBB2 TCF2 MMP28 GRB7 PEX12 CCT6B DHRS11 PIP4K2B PGAP3 TBC1D3B TBC1D3E CCL8 TBC1D3C CWC25 PIGW CCL7 TEC TBC1D3I TCAP AATF CCL1 IKZF3 CISD3 DUSP14 TBC1D3H RDM1 SOCS7 ARL5C CCL3L3 C17orf50 GPR179 CCL16 STARD3 FNDC8 UNC45B SLC35G3 SRCIN1 PPP1R1B SLFN12 SLFN13 RAD51D TBC1D3 SLFN11 SLFN14 ZNF830 SLFN5 GGNBP2 INDUCTION OF AUTOPHAGY AND TOLL LIKE RECEPTOR SIGNALING BY GRAPHENE OXIDE %WIKIPATHWAYS_20260610%WP5336%HOMO SAPIENS Induction of autophagy and toll like receptor signaling by graphene oxide IFNB1 MYD88 TLR4 NFKB1 TLR9 IRF3 MAP1LC3A IFNG TNF TRAF6 WNT SIGNALING NETPATH%WIKIPATHWAYS_20260610%WP363%HOMO SAPIENS Wnt signaling NetPath PRKCB NFATC2 PRKCA CCND1 CSNK1A1 GSK3B BCL9 ARHA MAPK8 RYK TSC2 TSC1 MAPK1 AXIN1 GCKR CSNK1G1 DKFZp686L0365 PPARG ROR1 GSK3A DVL2 APC ROR2 STM7 DVL3 TCF4 MTOR FRAT1 CTBP1 LEF1 PI4K2A MAPK9 CDK6 TCF3 LRP5 TCF7L2 SOX1 MAP3K7 hCG_2014051 LRP6 NLK CSNK1D DVL1 RAC1 ENDOPLASMIC RETICULUM STRESS RESPONSE IN CORONAVIRUS INFECTION%WIKIPATHWAYS_20260610%WP4861%HOMO SAPIENS Endoplasmic reticulum stress response in coronavirus infection EIF2AK1 MBTPS2 PPP1R1A MAPK8 PPP1R3B PPP1R15B PPP1R13B PPP1R11 ERN1 PPP1R10 PPP1R9A PPP1R3A PPP1R7 PPP1R2 PPP1R8 PPP1R12C PPP1R16B PPP1R14B PPP1R14C PPP1R16A ATF4 PPP1R3G PPP1R3F PPP1R3C PPP1R3E PPP1R1C sm-M20 PPP1R3D PPP1R14D EIF2AK2 EIF2S1 BCL2 PPP1R15A PPP1CC XBP1 HEL-S-80p DDIT3 PPP1R14A PPP1R1B HEL-S-89n MAP1LC3A MBTPS1 SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260610%WP4658%HOMO SAPIENS Small cell lung cancer RARB ITGA6 PIK3CA CDKN1C BIRC7 ITGB1 COL4A3 ITGA2 COL4A5 RXRA E2F3 CDKN2B TRAF1 IKBKB AKT3 IKBKG CHUK BAX ITGA2B TRAF2 PIK3CD CKS1B CKS2 TRAF3 RELA TRAF6 TRAF5 COL4A2 COL4A1 COL4A4 COL4A6 LAMB4 BCL2L1 SKP1 RB1 CCND1 MYC PIK3R3 PIK3R2 NFKBIB PIK3R1 E2F2 LAMC2 LAMC1 NFKB1 APAF1 DDB2 CCNE2 CCNE1 BIRC2 POLK BIRC3 LAMA5 LAMA1 NOS2 LAMA4 FHIT LAMA3 RXRB GADD45B RXRG GADD45A CDK4 GADD45G CDK2 BCL2 CDK6 LAMB3 NFKBIA LAMB2 BAK1 CYCS LAMB1 CDKN1A CDKN1B PTEN TRAF4 CASP9 CASP8 CASP3 ITGAV PTGS2 MAX TYPE I INTERFERON INDUCTION AND SIGNALING DURING SARS COV 2 INFECTION%WIKIPATHWAYS_20260610%WP4868%HOMO SAPIENS Type I interferon induction and signaling during SARS CoV 2 infection MYD88 STAT2 IKBKE TMPRSS2 MAVS RIGI TLR4 STAT1 TBK1 IRAK4 IFNAR2 ACE2 TLR9 EIF2AK2 IRF3 TREML4 IFIH1 TRAF3 TLR3 TYK2 TRAF6 IRF7 TLR7 OAS1 IFNAR1 IRF9 OAS2 JAK1 OAS3 PATHOPHYSIOLOGICAL ROLES OF DUX4 IN FSHD1%WIKIPATHWAYS_20260610%WP5342%HOMO SAPIENS Pathophysiological roles of DUX4 in FSHD1 RET MYOG TRIM63 EP300 FBXO32 MYC ADRB2 H3Y1 MYOD1 MYF5 H3Y2 DUX4 CDKN1A PAX7 NR3A2 PPARGC1A VEGFA LEPTIN AND ADIPONECTIN%WIKIPATHWAYS_20260610%WP3934%HOMO SAPIENS Leptin and adiponectin PRKAA1 CPT1A ACACA ADIPOR2 ADIPOR1 LEP PRKAG1 PRKAB1 LEPR INTEGRATED BREAST CANCER PATHWAY%WIKIPATHWAYS_20260610%WP1984%HOMO SAPIENS Integrated breast cancer pathway CDK7 XRCC3 BMPR1A TGFBR2 CREB1 RHO STK11 SMAD6 SELENOK WEE1 HIPK2 TRADD APOBEC3G EP300 HMGCR IRS1 CERK ZMYND8 NAB1 PIAS1 MAP3K7CL ZMIZ1 ALKBH1 RALGAPA1 CCNB1IP1 LGALS13 PLK3 SMAD4 ERAL1 FER PIGR FOSL2 RASGEF1A RASGRP3 FADD FOSL1 DCAKD ITPKC EDAR USP16 TFPI USP21 FILIP1 ATF1 RB1 CCND1 CHEK2 MYT1 MYC CHEK1 FAU TSC2 TSC1 CDC25B AURKA MSH6 TGFBR1 MSH2 MAP3K13 GSK3A BLM ZNF655 USP15 SMEK1 DAG1 RAP1A MAP3K7IP1 BARD1 SMAD2 JUN PLK1 SMARCA4 RHEB GADD45A CDK4 SP1 NOXA1 PML AHR BACH1 PPP4R3B UBE2F CDK2 BCL2 MDM2 RAD51 ATM ATR PTEN BRCA1 CASP9 CASP8 CASP3 JAK1 RAC1 CDC42 PAK1 MAPK1 EGFR BAD ARAF STAT1 GRN RRAS MRE11A MTOR CHUK RAD50 BAX RPP38 RALA SMAD1 CSNK1D SIRT1 BRCA2 VEGFA NUP85 GDI1 TPR NF1 PIK3R2 FOXO1 NFKB1 PKIA ANXA1 BMPR2 DHTKD1 BAK1 MYCBP2 HDAC1 MAX INFLAMMATORY BOWEL DISEASE SIGNALING%WIKIPATHWAYS_20260610%WP5198%HOMO SAPIENS Inflammatory bowel disease signaling IL-21 IL18RAP NFATC1 IL6 IL22 HLA-DMA MAF RORA TLR4 FOXP3 NFKB1 TBX21 IFNGR1 STAT1 IL23A IL2RG TNF STAT3 IL5 SMAD2 JUN GATA3 IL12RB1 IL10 IL21R IL12A TLR5 IL2 IL4 TGFB1 IL13 IL23R IL17F NOD2 IL18 STAT4 IL1A IFNG RORC ARTEMISININ INHIBITION OF UVEAL MELANOMA%WIKIPATHWAYS_20260610%WP5441%HOMO SAPIENS Artemisinin inhibition of uveal melanoma MTOR AKT3 ATOPIC DERMATITIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260610%WP5538%HOMO SAPIENS Atopic dermatitis mechanism and therapies IL5 MS4A2 IL1RL1 FCER1G CRLF2 IL25 IL33 TYK2 IL4 IL13 IL13RA1 OSMR JAK3 TSLP STAT3 IL2RG FCER1A NOD LIKE RECEPTOR NLR SIGNALING%WIKIPATHWAYS_20260610%WP288%HOMO SAPIENS Nod like receptor NLR signaling MAPK8 ERBIN IKBKG CHUK MAP3K7 EPHB2 CD40 RELA IKBKB CALORIC RESTRICTION AND AGING%WIKIPATHWAYS_20260610%WP4191%HOMO SAPIENS Caloric restriction and aging IGF1 MTOR PPARGC1A PRKAB2 SIRT1 NAMPT VALPROIC ACID PATHWAY%WIKIPATHWAYS_20260610%WP3871%HOMO SAPIENS Valproic acid pathway CYP2A6 CYP2B6 IVD HSD17B10 ACADSB ABAT HADHB HDAC1 EHHADH CYP2C9 SARS COV 2 AND ACE2 RECEPTOR MOLECULAR MECHANISMS%WIKIPATHWAYS_20260610%WP4883%HOMO SAPIENS SARS CoV 2 and ACE2 receptor molecular mechanisms AGTR1 TMPRSS2 ACE2 REN MAS1 NEURAL CREST DIFFERENTIATION%WIKIPATHWAYS_20260610%WP2064%HOMO SAPIENS Neural crest differentiation HDAC5 NOTCH4 RBPJ HES5 NOTCH1 MYB AXIN2 HDAC8 DLL3 DLL4 ITGB1 SOX5 OLIG2 SOX10 HES1 CTBP2 MPZ NEUROG1 PMP22 CDH6 ASCL1 PAX3 GBX2 DVL3 TCF4 COL11A2 MBP FGF19 TFAP2B HDAC10 FGF8 CDH2 MSX2 WNT3A TBX6 SOX9 TCF7L1 HDAC2 SMAD1 ISL1 FGF2 HOXA1 DLX5 HAND1 HEY2 OLIG1 TFAP2A FGFR2 MSX1 ZIC5 DMBX1 MIA LHX1 OLIG3 DCT ZIC1 HOXB1 PRTG ID1 MYC LHX5 GJB1 GSK3B FGFR1 GFAP TLX2 AXIN1 PAX7 WNT8A NFKB1 TWIST1 NFKB2 DVL2 FZD3 COL2A1 FGFR3 NOTCH2 HDAC11 PHOX2B FOXD3 SNAI1 SNAI2 HDAC3 BMP7 BMP4 HDAC7 HDAC1 DVL1 RHOB WNT1 NOTCH3 STEROID HORMONE PRECURSOR BIOSYNTHESIS%WIKIPATHWAYS_20260610%WP5277%HOMO SAPIENS Steroid hormone precursor biosynthesis AKR1C1 SRD5A2 HSD3B2 AKR1D1 CYP21A2 HSD3B1 CYP17A1 CYP11A1 HIJACK OF UBIQUITINATION BY SARS COV 2%WIKIPATHWAYS_20260610%WP4860%HOMO SAPIENS Hijack of ubiquitination by SARS CoV 2 NAE1 CBFB RBX1 ELOC UBA3 2Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260610%WP5223%HOMO SAPIENS 2q21 1 copy number variation syndrome CDC27 AMER3 STMN2 MZT2A FAM168B ARHA CCDC74A TUBA2 POTEE GPR148 CCDC42 APC ARHGEF4 STAT3 RAC1 FATTY ACID OMEGA OXIDATION%WIKIPATHWAYS_20260610%WP206%HOMO SAPIENS Fatty acid omega oxidation CYP1A2 HEL-S-4 CYP1A1 ADH1C ALDH2 CYP3A4 CYP2A6 CYP2E1 HEL-S-117 CYP4A11 ADH7 HEL-S-53e ADH1A INHIBITORS OF METABOLISM IN MELANOMA THERAPY%WIKIPATHWAYS_20260610%WP5609%HOMO SAPIENS Inhibitors of metabolism in melanoma therapy PDHA1 RPS6KA2 RPS6KA1 HEL-S-133P MAP2K1 NAMPT MAP2K2 CPT1A HEL-S-304 MAPK1 PPARGC1A MLST8 MAPK3 RAF1 ARAF PFKFB2 MTOR ACSS1 DLAT DLD RPTOR GPX4 HEL-S-30 HEL-75 GLS PKLR SLC16A3 HEL-S-281 SPHINGOLIPID METABOLISM OVERVIEW%WIKIPATHWAYS_20260610%WP4725%HOMO SAPIENS Sphingolipid metabolism overview SPHK1 SGMS2 SGPP1 UGCG SMPD1 SGPP2 DEGS1 PLPP3 GBA2 PLPP2 KDSR PLPP1 SPTLC2 CERS3 SPTLC1 CERS2 CERS6 CERK SGMS1 LASS1 UGT8 DEGS2 SGPL1 SPHK2 PHOSPHOINOSITIDE 3 KINASE PI3K FAMILY%WIKIPATHWAYS_20260610%WP5472%HOMO SAPIENS Phosphoinositide 3 kinase PI3K family PIK3R2 PIK3R1 PIK3CA PIK3R5 PIK3R4 PIK3CD PIK3C2G PIK3C2B PIK3R3 GLUCOCORTICOID RECEPTOR PATHWAY%WIKIPATHWAYS_20260610%WP2880%HOMO SAPIENS Glucocorticoid receptor pathway MFGE8 DNER NR3C1 CDKN1C STOM NR1i2 SLC26A2 FGD4 RXRA IL11 PDE4B PPP1R14C THBD SPRY1 AMIGO2 ZIC2 B3GNT5 ACKR3 ALOX5AP TNFAIP3 CCL2 NR1I3 RGS2 SLC19A2 EPB41L4B NFKB2 ARL5B ENC1 ANKRD1 ANGPTL4 SRGN S100P EDN2 TSC22D3 NAV3 BHLHB2 ADGRF4 CDC42EP3 SCNN1A BIRC2 PMP2 BIRC3 ABHD2 PRRG4 JUN GPR153 SERTAD2 MGAM GADD45B CAVIN2 PLK2 DNAJC15 TNS4 KTN1 CPEB4 PTGES3 CCL20 FGFBP1 SNAI2 POU5F1 PTGS2 TGFBR3 BIOGENIC AMINE SYNTHESIS%WIKIPATHWAYS_20260610%WP550%HOMO SAPIENS Biogenic amine synthesis ChAT GAD2 DDC HDC PNMT DBH PAH TH ACHE GAD1 MAOA ASMT AANAT TPH1 GDNF SIGNALING%WIKIPATHWAYS_20260610%WP5143%HOMO SAPIENS GDNF signaling AMINO ACID METABOLISM PATHWAY EXCERPT HISTIDINE CATABOLISM EXTENSION%WIKIPATHWAYS_20260610%WP4661%HOMO SAPIENS Amino acid metabolism pathway excerpt histidine catabolism extension FTCD GPT2 GLUD1 HAL UROC1 LIDOCAINE METABOLISM%WIKIPATHWAYS_20260610%WP2646%HOMO SAPIENS Lidocaine metabolism CYP1A2 CYP3A4 NEPHROTOXCICITY ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260610%WP5229%HOMO SAPIENS Nephrotoxcicity adverse outcome pathway SLC31A1 SLC22A2 PI3K AKT MTOR VITAMIN D3 SIGNALING%WIKIPATHWAYS_20260610%WP4141%HOMO SAPIENS PI3K AKT mTOR vitamin D3 signaling PDHA1 SLC2A3 MTOR PFKFB4 PIK3CA NR1i1 HEL-S-133P IL10 PRKAA2 MYC IL12A GSK3B RELA TSC2 RXRA TSC1 CYP24A1 CD80 HK3 NUCLEAR RECEPTORS META PATHWAY%WIKIPATHWAYS_20260610%WP2882%HOMO SAPIENS Nuclear receptors meta pathway SLC5A5 EGR1 NR3C1 TXN HES1 GPX2 TNF GPX3 GSTT2 PDE4B EP300 SLC5A1 SLC5A2 PLTP SLC6A20 APOA2 APOC3 APOA5 B3GNT5 SLC6A18 SLC5A8 CCL2 NR1i1 GCLM ABCB4 NR1I3 ABCG8 NR1H4 ABCG5 ABCB11 TGFA PCK1 S100P POLK CDC37 EPHA2 CYP7A1 SLC39A2 SLC39A1 SLC39A3 NR1H3 GSTM1 TGFBR3 MFGE8 HMOX1 UGT1A1 ACOX1 SERPINB2 GSTM4 IL1B IL11 DBI FABP1 EGFR UGT1A4 FGF19 UGT1A3 HSP90AB1 UGT1A9 UGT1A7 AMIGO2 PTPA ACKR3 SLC6A19 HEL-75 ALOX5AP PTGR1 GPAM SLC6A3 RGS2 FOXO1 ANGPTL4 BIRC2 SLC2A2 BIRC3 SLC2A3 CYP3A7 TNS4 FGFBP1 TGFBR2 CDKN1C STOM SLC26A2 DNAJB1 KLK15 NR0B2 PPP1R14C SCD FASN THBD AGER CPT2 IL2 EHHADH SLC6A13 SLC27A1 SLC6A11 JUNB SERPINA1 JUND TNFAIP3 CCND1 SQSTM1 MYC BAAT CYP8B1 SLC39A9 FTH1 SLC7A11 SLCO2B1 SLC39A6 IP6K3 SLC39A5 SLC27A5 GSTM2 SLC39A8 SLC6A17 SLC6A16 SLC19A2 HGF SLC5A7 SLC5A9 CES8 EPHA3 HEL-S-10 EPB41L4B MGST3 ARL5B MGST2 ENC1 ADH7 ANKRD1 SLC5A3 FKBP5 SRGN SLC5A4 EDN2 NRG1 SMC1A TSC22D3 SLC2A9 HEL-S-128m NAV3 SLC6A5 ADGRF4 SLC6A7 CDC42EP3 SLC6A9 SCNN1A UGT2B4 GSTM5 PMP2 ABHD2 SRXN1 JUN SLC2A6 PRRG4 SLC6A2 GPR153 SERTAD2 SLC2A7 UGT2B7 CDC2 SLC2A8 GADD45B SLC2A14 CAVIN2 PLK2 SLC2A11 CDK4 SLC2A10 DNAJC15 SP1 MGST1 SLC2A13 KTN1 CPEB4 AHR FGF13 HEL-S-25 SLC39A11 CAP2 GCC1 SLC39A10 PTGES3 MYOF SLC39A13 SLC39A12 AIP SNAI2 SLC39A14 ALDH3A1 AHRR SMVT CES3 SLC5A12 CDKN1B SLC5A10 GSTA5 GSTA4 GSTA3 CYP4A11 IFNG ME1 KAT2B HBEGF DNER NQO1 KEAP1 GCLC ABCC3 NCOA1 ABCC2 ABCB1 NR1i2 CYP2C19 CYP4F12 CYP2C9 SLCO1B1 FGD4 CYP2A6 RXRA CYP2B6 SRPX2 DNAJC7 PPARGC1A SMARCA1 SLC7A5 FTL SULT2A1 STAT3 NR1C2 BAX SPRY1 ZIC2 SULT1A1 SLC2A12 SLC6A8 SRC HEL126 CES2 CES1 CYP1A2 CYP1A1 CYP1B1 CYP3A4 MAFG MAFF CPT1A NFE2L2 NFKB2 SLC2A4 PDK4 BHLHB2 GSTM3 ALAS1 HEL-S-22 NCOA6 IL12B IL12A CCL20 TGFB1 IGFBP1 IL17B ACADM ABCC5 NR1C1 POU5F1 PTGS2 PATHOGENESIS OF SARS COV 2 MEDIATED BY NSP9 NSP10 COMPLEX%WIKIPATHWAYS_20260610%WP4884%HOMO SAPIENS Pathogenesis of SARS CoV 2 mediated by nsp9 nsp10 complex CRP CD3G CD3E IL6 CD8B IGLL1 HLA-DRB5 CD8A MMP25 NRF CD2 LBP ZAP70 HLA-DRB1 LCK PRG3 CXCL8 FYN MBDNF AND PROBDNF REGULATION OF GABA NEUROTRANSMISSION%WIKIPATHWAYS_20260610%WP4829%HOMO SAPIENS mBDNF and proBDNF regulation of GABA neurotransmission PLCG1 PIK3CA GABRB3 GABRB2 GABRB1 CREB1 AP2A1 AP2A2 PIK3R3 ARHA SHC1 PIK3R2 PIK3R1 NTRK2 CREM STAT3 ROCK1 GABRE GABRQ GABRA2 GABRP SLC12A5 GABRA6 GABRA5 GABRA4 GABRA3 GABRG3 PTEN GABRG1 NGFR BDNF TARGETING YAP IN PANCREATIC DUCTAL ADENOCARCINOMA PDAC %WIKIPATHWAYS_20260610%WP5495%HOMO SAPIENS Targeting YAP in pancreatic ductal adenocarcinoma PDAC MOB1A HMGCR TEAD2 RHOD TEAD3 TEAD4 PRKAA2 LATS1 PRKAB2 PRKAB1 RHO CTGF ARHA PRKAA1 LATS2 YAP1 STK4 PRKAG1 RHOB PRKAG2 CYR61 PRKAG3 PANCREATIC ADENOCARCINOMA PATHWAY%WIKIPATHWAYS_20260610%WP4263%HOMO SAPIENS Pancreatic adenocarcinoma pathway MAPK10 PIK3CA TGFBR2 CDC42 MAPK8 PAK1 MAPK1 E2F3 MAPK3 EGFR BAD ARAF STAT1 CDKN2A STAT3 IKBKB AKT3 IKBKG MTOR CHUK BAX PIK3CD RALBP1 RELA PLD2 HEL-S-34 RALA RPS6KB2 SMAD4 BRCA2 VEGFA BCL2L1 RPS6KB1 RB1 CCND1 ERBB2 EGF MAP2K1 MAP2K2 TGFA PIK3R3 PIK3R2 PIK3R1 E2F2 TGFBR1 NFKB1 RAC3 RAF1 DDB2 POLK SMAD2 GADD45B GADD45A CDK4 GADD45G PAK6 MAPK9 PAK4 CDK6 RAD51 TGFB1 dik BAK1 CDKN1A CASP9 RALB JAK1 RAC1 PHYSICO CHEMICAL FEATURES AND TOXICITY ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260610%WP3680%HOMO SAPIENS Physico chemical features and toxicity associated pathways NEFH ERBB4 SOS1 MYL1 ARHA MAPK8 PAK1 MAPK1 EGFR APC GPX1 TMSB4X MYLK CBL SRC NEF3 MAP2K4 PLCG1 PFN1 NEFL ERBB2 MYC MAP2K1 GSK3B DAAM1 TGFA FZD10 HEL-S-44 SHC1 NCK1 WNT16 FZD7 AXIN1 FZD8 RAF1 FZD3 FZD5 FZD4 CAMK1 FZD9 PPP2CA JUN ROCK2 GRB2 ACTR3 CDKN1A ACTR2 CDKN1B PFN4 PFN2 ACTA1 PFN3 DVL1 FZD1 FZD2 T CELL ACTIVATION SARS COV 2%WIKIPATHWAYS_20260610%WP5098%HOMO SAPIENS T cell activation SARS CoV 2 MYD88 SOS1 DEPTOR MAPK1 RICTOR MAPK3 IL23A CDKN2A TNF CTLA4 IKBKB PPP3CC IKBKG MTOR CHUK BAX CCL19 IL12RB1 IFNAR2 PIK3CD RELA TYK2 IL2 ZAP70 LCK IFNAR1 STAT4 FYN ICOS IL18R1 GRAP2 PTPRC BCL2L1 PLCG1 IFNB1 LCP2 CARD11 PDPK1 NFATC1 CD3G PRKCQ CD3E BCL10 CCND1 MAP2K1 GSK3B MAP2K2 LAT TSC2 PIK3R1 TSC1 NFKB1 MLST8 FOXO3A RAF1 CD80 LTA JUN RHEB IL12B IL12A IL4 NFKBIA GRB2 IL23R CDKN1A HLA-DRB1 CCL28 PTEN IRF2BPL IL17A RPTOR HRAS CD3D IFNG FOS LIPID METABOLISM PATHWAY%WIKIPATHWAYS_20260610%WP3965%HOMO SAPIENS Lipid metabolism pathway PDHA1 ACACA PRKACG ABHD5 ACLY LIPE FASN PRKAR1B PRKAR1A PRKAA2 HILPDA PNPLA2 PRKAB2 PRKAB1 PRKAA1 PLIN1 ACSS2 PRKAG1 PRKAG2 PRKAG3 AKT3 KCNQ2 RELATED EPILEPSIES%WIKIPATHWAYS_20260610%WP5360%HOMO SAPIENS KCNQ2 related epilepsies PPP3CC CHRM1 PRKCA CSNK2A1 BACE1 KCNQ2 KCNQ3 PLCG2 CALM1 AGTR1 STX1A SCN1B P2RY1 BDKRB2 PPP1R10 AKAP5 GLYCOGEN SYNTHESIS AND DEGRADATION%WIKIPATHWAYS_20260610%WP500%HOMO SAPIENS Glycogen synthesis and degradation GSK3B PHKG2 PPP2R2A GYG1 GSK3A PPP2R1B PPP2R1A PPP2CA HK2 PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C CALM1 PTPA GYS2 PYGB PYGM AGL PHKB GYS1 PHKA1 PYGL PPP2R3B PHKA2 HK3 PPP2R3A PPP2R2C PPP2R2B ISOGLOBO SERIES SPHINGOLIPIDS%WIKIPATHWAYS_20260610%WP5311%HOMO SAPIENS Isoglobo series sphingolipids B3GALT5 FLUOROPYRIMIDINE ACTIVITY%WIKIPATHWAYS_20260610%WP1601%HOMO SAPIENS Fluoropyrimidine activity DPYS SMUG1 SLC29A1 TK1 XRCC3 TYMP ABCC3 ERCC2 DPYD CYP2A6 TDG UMPS TYMS ABCG2 RRM1 RRM2 DHFR UCK2 ABCC5 UCK1 FPGS SLC22A7 UPP2 CES2 CDA GGH CES1 CAFFEINE AND THEOBROMINE METABOLISM%WIKIPATHWAYS_20260610%WP3633%HOMO SAPIENS Caffeine and theobromine metabolism CYP1A2 CYP2A6 XDH NAT2 BIOSYNTHESIS AND REGENERATION OF TETRAHYDROBIOPTERIN AND CATABOLISM OF PHENYLALANINE%WIKIPATHWAYS_20260610%WP4156%HOMO SAPIENS Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine MAOA SPR ASMT DHFR JDP1 PTS AANAT PNMT PAH DBH TH EXTRACELLULAR VESICLE MEDIATED SIGNALING IN RECIPIENT CELLS%WIKIPATHWAYS_20260610%WP2870%HOMO SAPIENS Extracellular vesicle mediated signaling in recipient cells SMAD2 MTOR MFGE8 TGFBR2 CD133 TSPAN8 ERBB2 WNT3A TGFA TGFB1 HGF NRAS AXIN1 TGFBR1 SMAD4 RAF1 EGFR DKK4 APC HRAS TGFBR3 EXERCISE AND HYPERTROPHY IN SKELETAL MUSCLE%WIKIPATHWAYS_20260610%WP516%HOMO SAPIENS Exercise and hypertrophy in skeletal muscle EIF4EBP1 MYOG HBEGF HEL-S-52 MSTN DUSP14 NR4A3 IL1R1 ADAM10 IFRD1 IL18 JUND ANKRD1 IL1A EIF4E ATF3 IFNG VEGFA CYR61 ONCOSTATIN M SIGNALING%WIKIPATHWAYS_20260610%WP2374%HOMO SAPIENS Oncostatin M signaling SOS1 EGR1 CREB1 MAPK8 MAPK1 PTK2B RICTOR MAPK3 STAT1 STAT3 IL6ST PTPN11 MAPK14 MTOR IRS1 RELA TYK2 STAT5B JUNB SOCS3 JAK3 JUND SRC HIF1A VEGFA PRKCB PRKCH PRKCA MAP2K1 MAP2K2 SHC1 PIK3R1 CEBPB NFKB1 RPS6 RAF1 PXN PRKCE CDK2 MAPK9 NFKBIA GRB2 CDKN1B OSMR CASP3 HRAS JAK1 OSM FOS MOLECULAR PATHWAY FOR OXIDATIVE STRESS%WIKIPATHWAYS_20260610%WP5477%HOMO SAPIENS Molecular pathway for oxidative stress MAP2K4 PINK1 PIK3CA HMOX1 NQO1 KEAP1 GSX1 IL6 IPCEF1 PIP MAP3K5 CREB1 RPS6KA5 CHEK1 MAPK8 NFE2L2 FOXO1 TSC1 NFKB1 CXCL8 ATF2 TNF IKBKB CCNE1 MAPK14 IKBKG MTOR NOS2 RHEB CDK2 MAP2K3 BCL2 MDM2 NRF1 ATR CDKN1A PTEN IL1A SIRT1 PTGS2 BCL2L1 FOS NEOVASCULARIZATION PROCESSES%WIKIPATHWAYS_20260610%WP4331%HOMO SAPIENS Neovascularization processes REL NOTCH4 NOTCH1 SMAD9 ACVRL1 RELB DLL4 CXCL12 DKFZp781O1323 MAPK8 MAPK1 CXCR4 TGFBR1 NFKB1 NFKB2 MAPK3 SMAD2 KIT FLT4 RELA MAPK9 TGFB1 EPHB2 SMAD1 EPHB4 ANGPT1 HIF1A MMP9 KDR NOTCH3 KITLG MITOCHONDRIAL FISSION AND FUSION%WIKIPATHWAYS_20260610%WP4318%HOMO SAPIENS Mitochondrial fission and fusion OPA1 MFN1 BNIP3 BAX MFN2 MIB1 FIS1 MTFP1 SH3GL2 BCL2L1 RESISTIN AS A REGULATOR OF INFLAMMATION%WIKIPATHWAYS_20260610%WP4481%HOMO SAPIENS Resistin as a regulator of inflammation PLCG1 PIK3CA PLCB3 PLCB4 IL6 PLCG2 RETN PLCB1 PLCB2 PLCD4 MAPK1 NFKB1 CXCL8 MAPK3 TNF IKBKB AKT3 PLCE1 MAPK14 IKBKG CHUK PLCD3 PIK3CD IL12B IL12A RELA NFKBIA MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260610%WP4190%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway HMGCS1 HMGCR HMGCL ACAT1 GGPS1 IDI2 MVD FDFT1 FDPS MVK PMVK ACAT2 GLYCOSYLPHOSPHATIDYL INOSITOL ANCHOR PATHWAY%WIKIPATHWAYS_20260610%WP5505%HOMO SAPIENS Glycosylphosphatidyl inositol anchor pathway PGAP3 DPM2 PIGW PIGF PIGS PIGU PIGT PIGX PGAP1 PIGO PGAP2 PIGN GPAA1 PIGP PIGM PIGV PIGY PIGC PIGB PIGA PIGK MPPE1 PIGL PIGH MIRNA REGULATION OF PROSTATE CANCER SIGNALING%WIKIPATHWAYS_20260610%WP3981%HOMO SAPIENS miRNA regulation of prostate cancer signaling MTOR IKBKG PDGFA PIK3CA SOS1 CCND1 MAP2K1 BCL2 GSK3B MDM2 MAP2K2 NFKBIA GRB2 CDKN1A CDKN1B FOXO1 MAPK1 NFKB1 CREBBP CASP9 RAF1 BAD KLK3 AKT3 INTERACTIONS BETWEEN LOXL4 AND OXIDATIVE STRESS PATHWAY%WIKIPATHWAYS_20260610%WP3670%HOMO SAPIENS Interactions between LOXL4 and oxidative stress pathway SUV39H1 HEL-S-7 CDC37 NQO1 ECSIT FGF7 EXOC6 TGFB1 NRF1 PKD1 NFE2L2 IGFBP7 SIRT1 BMP2 COL2A1 DDR1 LOXL4 ESTRADIOL REGULATION IN PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260610%WP5235%HOMO SAPIENS Estradiol regulation in porto sinusoidal vascular disease KCNN3 SP1 SP3 CALM1 LNCRNA IN CANONICAL WNT SIGNALING AND COLORECTAL CANCER%WIKIPATHWAYS_20260610%WP4258%HOMO SAPIENS lncRNA in canonical Wnt signaling and colorectal cancer AXIN2 KREMEN1 WIF1 CSNK1A1 RYK NOTUM CTBP2 ROR1 ROR2 APC MACROH2A2 DVL3 PORCN CDK8 CHD8 SOST SENP2 LEF1 WNT3A CXXC4 TCF7L2 TCF7L1 hCG_2014051 CSNK1A1L NLK ATF3 FOSL1 TFAP2A EZH2 APC2 CSNK2A1 CCND1 MYC GSK3B CTNNBIP1 WNT2B FZD10 WNT5B CCND3 CCND2 WNT16 FZD7 AXIN1 FZD8 WNT3 RUVBL1 SFRP4 WNT4 DVL2 WNT10B WNT10A FZD3 FZD5 WNT7B FZD9 WNT7A JUN FRAT1 CTBP1 CDK6 FRAT2 NKD1 NKD2 TCF3 SOX17 LRP5 MAP3K7 CER1 CSNK2A3 CSNK2A2 LRP6 DKK1 DKK2 DKK4 SFRP1 SFRP5 DVL1 FZD1 CSNK2B WNT1 FZD2 S1P RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20260610%WP26%HOMO SAPIENS S1P receptor signal transduction SPHK1 PLCB3 S1PR1 S1PR2 S1PR3 S1PR5 PLCB1 PLCB2 MAPK7 GNAI3 MAPK6 MAPK4 MAPK1 MAPK12 MAPK3 SPHK2 SMPD2 PIK3C2B GNAI1 AKT3 TRANSLATION INHIBITORS IN CHRONICALLY ACTIVATED PDGFRA CELLS%WIKIPATHWAYS_20260610%WP4566%HOMO SAPIENS Translation inhibitors in chronically activated PDGFRA cells MAP2K4 MAPK10 PIK3CA RPS6KA2 PRKCA RPS6KA1 CSNK2A1 EIF4A2 MAP2K5 RPS6KA5 MAP2K1 EIF4G1 MAP2K2 PIK3R3 PIK3R2 MAPK8 PIK3R1 MAPK1 MAPK3 RPS6 AKT3 EIF4EBP1 PIM1 PIM2 MAPK14 MTOR EIF4A1 RPS6KA4 MAP2K3 MAPK9 RPTOR RPS6KB2 EIF4E EIF4B MAP2K6 RPS6KB1 MICROGLIA PATHOGEN PHAGOCYTOSIS PATHWAY%WIKIPATHWAYS_20260610%WP3937%HOMO SAPIENS Microglia pathogen phagocytosis pathway TYROBP PTPN6 NCF1 NCKAP1L NCF2 PIK3CA FCER1G PLCG2 CYBB PIK3R3 LAT PIK3R2 PIK3R1 C1QA LYN ITGAM RAC3 TREM1 VAV3 C1QB SIGLEC7 PIK3CD FCGR1A VAV1 NCF4 SYK C1QC ARPC1B RAC1 VAV2 CYBA INTEGRATED CANCER PATHWAY%WIKIPATHWAYS_20260610%WP1971%HOMO SAPIENS Integrated cancer pathway ATF1 RB1 CHEK2 MAP3K5 MYC CHEK1 BBC3 CDC25B MSH6 MSH2 CDKN2B BAD BLM STAT1 POU2F1 MRE11A BARD1 SMAD2 RAD50 PLK1 BAX CDC2 CDK4 NOXA1 BACH1 CDK2 BCL2 MDM2 ATM ATR CDKN1A CDKN1B PTEN BRCA1 CASP9 CASP8 CASP3 JAK1 PLATELET MEDIATED INTERACTIONS WITH VASCULAR AND CIRCULATING CELLS%WIKIPATHWAYS_20260610%WP4462%HOMO SAPIENS Platelet mediated interactions with vascular and circulating cells CD40LG PF4 SELPLG IL1B TGFB1 VCAM1 TLR7 TLR4 SELE SELP CCL5 CD40 CCL2 CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260610%WP5304%HOMO SAPIENS Cholesterol metabolism NPC2 HSD17B7 DHCR7 CYP27A1 HMGCS1 NPC1L1 FABP2 DKFZp434B2017 CD36 SLC27A4 CYP51A1 STAR SCARB1 LIPG ANGPTL3 MTTP LPA HMGCR LIPC LRPAP1 APOH APOB CIDEB LDLR PLTP FDFT1 DGAT1 APOA2 LBR APOC3 APOA4 SQLE SOAT1 APOC2 APOC1 APOE LIPA PBR ABCG8 ABCG5 FDPS TM7SF2 MVK ABCB11 PMVK DHCR24 MYLIP ACAT2 LPL MGAT1 SORT1 PCSK9 VAPA EBP CYP7A1 ABCA1 STARD3 SC5D MSMO1 MVD NPC1 ECTODERM DIFFERENTIATION%WIKIPATHWAYS_20260610%WP2858%HOMO SAPIENS Ectoderm differentiation TNFRSF11B BMPR1A FHL2 GAS2L1 SNCA SMURF1 AHI-1 BOC SKIL GLB1 HDAC10 SMAD4 FYN NLK SDCBP CCL2 TNLG7C TFAP2A HMGB2 PDE7A MYC CLDN11 LDB2 FZD8 PRKAG2 CAP2 H2BC9 NLGN1 SOCS2 POU2F2 TBL1X CTNNA2 CDH8 CDH6 PAX3 ROR2 NR1C2 PIM1 BCOR GATA6 OGT TFAP2C SPRY2 CELSR2 ZFHX4 KCNK10 TLE5 MZF1 ASTN1 SCHIP1 LY6E ARX CTNND2 STC1 ARHGAP15 ZBTB2 TRPM2 TCF7L1 RHPN1 JUP ST8SIA4 ZBTB16 HESX1 ZBTB7B MKS1 GREB1 PAN2 PTPRB TOX3 PPFIBP2 MAFB WDR44 FOXA2 SIX6 ARHGDIG UBTF RAB8B FGFR2 BCAS3 ELOVL4 NFATC1 SORCS1 BAZ1A LHX1 FOXL1 SERPINB6 ARHGAP10 KIFC3 PTPN13 RUTBC3 STX16 RRBP1 SOX2 NR2F2 CLVS1 NUMA1 TTC14 C1GALT1 VAX2 RIT1 ZNF219 MYORG PLXNA2 DMD CDON FZD5 RGMA FZD4 GLI3 SHH CTBP1 KRT6A TCF3 NF2 ELOVL2 BMP4 WNT1 CLASSICAL PATHWAY OF STEROIDOGENESIS WITH GLUCOCORTICOID AND MINERALOCORTICOID METABOLISM%WIKIPATHWAYS_20260610%WP4523%HOMO SAPIENS Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism STAR HSD17B3 POR CYP17A1 H6PD HSD11B1 HSD11B2 SRD5A2 HSD3B2 CYP11B2 CYP21A2 HSD3B1 CYP11A1 GENETIC CAUSES OF PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260610%WP5269%HOMO SAPIENS Genetic causes of porto sinusoidal vascular disease NOTCH4 NCF1 RBPJ NCF2 NOTCH1 CDC42 DLL4 CYBB DOCK6 MAPK1 CYBC1 NFKB1 CXXC5 CHCHD2 MAPK3 C4orf54 COX4I2 BEND6 EFL1 SHCBP1 ARHGAP31 IBTK EIF6 SBDS KCNN3 NOX3 DGUOK GTF2I BTK SP1 TLR9 TLR8 NCF4 RAC1 CYBA TARGETED THERAPY IN BREAST CANCER%WIKIPATHWAYS_20260610%WP5496%HOMO SAPIENS Targeted therapy in breast cancer PIK3CA ERBB4 PIK3R4 ERBB3 ERBB2 PIK3CD PIK3R3 PIK3R2 PIK3R1 PIK3R5 NRAS MAPK1 MAPK3 RAF1 EGFR HRAS PIK3C2G PIK3C2B AKT3 BENZENE METABOLISM%WIKIPATHWAYS_20260610%WP3891%HOMO SAPIENS Benzene metabolism DHDH CYP2E1 EPHX1 NQO1 GSTM1 MPO HEART DEVELOPMENT%WIKIPATHWAYS_20260610%WP1591%HOMO SAPIENS Heart development PITX2 NFATC3 NFATC2 NFATC1 NOTCH1 BMPR1A ERBB3 NKX2-5 GATA4 VEGFB NFATC4 VEGFC MAPK1 BMP10 MEF2C FOXH1 BHLHB2 PTPN11 FOXC1 TBX2 BMPR2 GATA6 TBX1 FGF10 FOXC2 SHH HAND2 SMYD1 FGF8 TBX20 SMAD1 IRX4 TBX5 ISL1 SMAD4 BMP4 BMP2 HAND1 VEGFA FOXA2 HEY2 GABA RECEPTOR SIGNALING%WIKIPATHWAYS_20260610%WP4159%HOMO SAPIENS GABA receptor signaling GABBR1 GABRB3 GABRB2 GAD2 GABRB1 AP2A1 AP2A2 GABBR2 SLC32A1 ALDH9A1 GPHN GABRE ABAT AP2M1 GABRQ GABRA2 GABRP GABRA6 GABRA5 GAD1 GABRA4 GABRA3 SLC6A11 GABRG3 GABRG1 AP2S1 ETHANOL EFFECTS ON HISTONE MODIFICATIONS%WIKIPATHWAYS_20260610%WP3996%HOMO SAPIENS Ethanol effects on histone modifications HDAC5 KAT2B MTR HDAC8 ALDH2 CYP2E1 HEL-S-117 ATF2 HEL-S-53e ACSS2 TYMS ADH1A HDAC10 HAT1 ADH1C ALDH1A3 MAT1A HDAC3 DHFR HDAC2 ELP3 ALDH1A2 SLC19A1 HDAC7 HDAC1 IL19 SIGNALING%WIKIPATHWAYS_20260610%WP5422%HOMO SAPIENS IL19 signaling CCL11 MAPK14 MUC5AC CCNB1 ACTA2 COL1A1 IL4 TGFB1 MAPK8 MAPK1 CXCR4 NFKB1 IL20RA IL20RB SOCS1 MAPK3 SOCS5 IL19 STAT1 JAK1 STAT3 TNF RAC1 TNFRSF1A INHIBITION OF GNAQ REGULATED SIGNALING IN UVEAL MELANOMA%WIKIPATHWAYS_20260610%WP5490%HOMO SAPIENS Inhibition of GNAQ regulated signaling in uveal melanoma PKN1 PIK3CA PLCB3 PKN2 PLCB4 TEAD2 TEAD3 TEAD4 PLCB1 PLCB2 PIK3R3 ARHA PIK3R2 PIK3R1 TSC2 TSC1 LATS2 MAPK1 AKT3 MOB1A MTOR ROCK1 PIK3CD LATS1 TRIO YAP1 PKN3 FGFR3 SIGNALING IN CHONDROCYTE PROLIFERATION AND TERMINAL DIFFERENTIATION%WIKIPATHWAYS_20260610%WP4767%HOMO SAPIENS FGFR3 signaling in chondrocyte proliferation and terminal differentiation CNP PTH1R IHH FGF9 DKFZp686F0183 MAP2K1 MAP2K2 PTHLH MAPK1 MAPK3 RAF1 THRA STAT1 FGFR3 PPP2CA MAPK14 FGF18 NPR2 SNAI1 CDKN1A RBL1 SOX9 MAPK12 MAPK13 MAPK11 BMP4 BMP2 CHEMOKINE SIGNALING%WIKIPATHWAYS_20260610%WP3929%HOMO SAPIENS Chemokine signaling ADRBK1 PLCB3 PLCB4 PLCB1 PLCB2 CXCL9 DKFZp686L0365 CXCL13 CXCL3 GNGT1 CXCL5 GNGT2 CCR6 PRKACG PIK3CD GNAI3 VAV1 GNG3 IL8RB GNG10 JAK3 GNG5 GNG4 CCL5 ITK GNG7 CCL4 CCL3 GNG8 GNG12 GNG11 GNG13 GNB2 GNB1 NCF1 STAT2 GNB5 PPBP CRKL CXCL11 CXCL12 PF4 MAP2K1 SHC2 SHC3 SHC1 LYN RAF1 PXN TIAM1 RAP1A NFKBIA GRB2 CCL17 PIK3R5 GRK1 CCR10 CCR1 XCR1 HRAS RAC1 VAV2 CCR3 PIK3CA SOS1 CRK CDC42 CX3CL1 CCR8 CCR7 PAK1 CCR4 MAPK1 CCR2 CXCR4 PTK2B MAPK3 PARD3 STAT1 STAT3 IKBKB AKT3 GNAI1 CCL11 CXCR5 IKBKG CXCR6 GNB4 CHUK CCL19 SOS2 ADCY3 CCL15 ADCY1 CCL25 ADCY8 RELA CCL24 ADCY6 CCL22 STAT5B ADCY5 CCL21 ADCY9 GNG2 CCL27 CCL26 SHC4 CXCR3 CXCL14 PRKCB WAS CXCL16 WASL PRKCZ GSK3B PIK3R3 PIK3R2 NFKBIB PIK3R1 GRK5 NRAS GRK4 NFKB1 FOXO3A VAV3 XCL1 CX3CR1 ROCK1 PREX1 ROCK2 ELMO1 DOCK2 PRKX CCL7 CCL1 GNB3 CCL20 CCL28 c-fgr CSK FATTY ACID AND LIPOPROTEIN TRANSPORT IN HEPATOCYTES%WIKIPATHWAYS_20260610%WP5323%HOMO SAPIENS Fatty acid and lipoprotein transport in hepatocytes NPC2 MYLIP HEL-S-104 DBI FABP1 SORT1 FABP2 ACSL1 ACSL6 PCSK9 ACSL5 SLC27A4 ACSL3 STAR SCARB1 SLC27A2 LPA APOB LDLR SOAT2 ABCA1 SLC27A3 APOA4 SLC27A1 SOAT1 STARD3 APOC2 APOC1 APOE LIPA FAMILIAL HYPERLIPIDEMIA TYPE 5%WIKIPATHWAYS_20260610%WP5112%HOMO SAPIENS Familial hyperlipidemia type 5 APOA5 LPL APOC2 LIPC LDLR PLTP SEL1L GPIHBP1 APOA2 LMF1 APOA4 RUBINSTEIN TAYBI SYNDROME 1%WIKIPATHWAYS_20260610%WP5367%HOMO SAPIENS Rubinstein Taybi syndrome 1 IRF2 FOXO1 DDX21 NPAS2 CREBBP SMAD4 CREB1 FBL PCNA MAFG HEL23 PHOTODYNAMIC THERAPY INDUCED NF KB SURVIVAL SIGNALING%WIKIPATHWAYS_20260610%WP3617%HOMO SAPIENS Photodynamic therapy induced NF kB survival signaling REL EGLN2 IL6 RELB CCND1 MMP2 IL1B VCAM1 MMP3 BIRC5 BCL2L2 SELE CSF2 NFKB1 CXCL8 NFKB2 CXCL2 TNF IKBKB BIRC2 CD40LG BIRC3 CHUK BCL2A1 RELA IL2 TRAF6 IL1A PTGS2 MMP9 VEGFA TNFRSF1A SILDENAFIL TREATMENT%WIKIPATHWAYS_20260610%WP5294%HOMO SAPIENS Sildenafil treatment GUCY1B1 PDE4B PDE4A GUCY1A2 NOS2 PDE5A PDE4D GSK3B HEL-S-162eP NRF1 PARK2 ZNF746 TFAM PPARGC1A PRKG1 AKT3 MIR TARGETED GENES IN LEUKOCYTES%WIKIPATHWAYS_20260610%WP2003%HOMO SAPIENS miR targeted genes in leukocytes TMEM109 ACP2 SCYL1 HEL-S-47e TUBA1A RFT1 GOLGA7 ATP6V1F PRPF40A PTRH1 YWHAQ GNA13 DNAJB1 PHC2 FADS1 SAC3D1 MENT CDIPT ADPGK TYMS ANAPC1 UNC93B1 POLR2C FMNL2 POLE4 MTHFD2 BCL6 HEL-S-30 MCL1 MAP3K8 SLC7A11 LPL VPS39 RAB5C CAP1 SNAP23 BCL2 CHORDC1 CDK6 CDK5RAP3 ATP6V0E1 IFRD1 PISD GYS1 DCAF7 MRPL20 RDH10 HMOX1 SNX6 ANXA2 PLXND1 SPTLC1 SFXN1 DDX5 ARF4 POM121 TRAM1 MRC2 TMEM43 TMED3 NELFCD HMGA1 CTSC MAPK14 LAMTOR3 SLC7A6 CDCP1 FRG1 PTPA USP1 SHOC2 SRSF10 CA12 AP3D1 ARHG ARCN1 WDR11 HEL-S-26 THBS1 TUSC2 TNLG5A ARID4B TXN2 CEBPB HEL-S-66 MPDU1 KCNN4 PPIF PPIB TPM3 TMED10 PNP SLC1A4 ADIPOR2 RTN4 CORO1C CD164 BRPF3 LMNB2 TBCA IGF2R PRSS21 SLC25A1 TNFAIP2 ATP2A2 ADAR SERPINE2 DNA IR DOUBLE STRAND BREAKS AND CELLULAR RESPONSE VIA ATM%WIKIPATHWAYS_20260610%WP3959%HOMO SAPIENS DNA IR double strand breaks and cellular response via ATM KAT5 RASSF1 CHEK2 CHEK1 H2AX PCNA ATF2 TRIM28 NBN APAF1 MDC1 RIF1 BLM SMC1A PRKDC CDKN2A MRE11A FANCD2 RAD50 BAX MCPH1 RNF8 LATS1 NABP2 RAD52 MDM2 HSF1 RAD51 TRAF6 TP53BP1 CDK5 ATM BAK1 RAD17 TP73 ATR RAD9A BRCA1 YAP1 CASP9 SMC3 CASP3 TERF2 BRCA2 ACTL6A PLURIPOTENT STEM CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260610%WP2848%HOMO SAPIENS Pluripotent stem cell differentiation pathway GDF5 NOTCH1 EPO IL6 NODAL FGF4 EGF WNT2B NOG IGF1 HGF CSF1 IL11 WNT7B ALK PDGFA CXCR1 IL6R FGF10 KIT CSF1R SHH TF INS FGF8 FLT3LG TPO WNT3A CNTF TGFB1 NT5E FST LEFTY1 IL3 DKK1 BMP4 FGF2 NTF4 WNT1 INHBA VEGFA TNFSF11 KITLG LNCRNA LIKE NMRK2 IN TRANSLOCATION RENAL CELL CARCINOMA%WIKIPATHWAYS_20260610%WP5519%HOMO SAPIENS LncRNA like NMRK2 in translocation renal cell carcinoma MDH2 SLC19A2 NMRK2 CS FH NONO MAMMARY GLAND DEVELOPMENT INVOLUTION STAGE 4 OF 4%WIKIPATHWAYS_20260610%WP2815%HOMO SAPIENS Mammary gland development involution stage 4 of 4 CHI3L1 IL6ST BAX SOCS3 MYC MMP9 STAT3 MYD88 DISTINCT INPUT OUTPUT PATHWAY%WIKIPATHWAYS_20260610%WP3877%HOMO SAPIENS MYD88 distinct input output pathway MYD88 JUN TLR9 TLR8 TLR5 TRAF6 TLR10 TLR7 TLR4 HEL-S-71 NFKB1 TIFA UBE2V1 TLR1 IL1A IRAK1 AUTOPHAGY IN PANCREATIC DUCTAL ADENOCARCINOMA%WIKIPATHWAYS_20260610%WP5331%HOMO SAPIENS Autophagy in pancreatic ductal adenocarcinoma PINK1 HMGB1 AGER SQSTM1 MDM2 PARK2 VMP1 DKFZp762B153 IPO8 NFE2L2 SHOC2 NFKB1 TFEB STAT3 10Q22Q23 COPY NUMBER VARIATION%WIKIPATHWAYS_20260610%WP5402%HOMO SAPIENS 10q22q23 copy number variation SHLD3 LRIT1 PRXL2A SHLD2 ERBB4 SHLD1 BMPR1A SH3GL3 CCSER2 OPN4 ROPN1L RSPH6A DYDC1 CEBPA MAD2L2 RSPH14 NRG3 MAT1A IQUB RSPH9 ADAM10 NME5 VEGFA RSPH3 STAG1 BUB1B RSPH1 GLUD1 NFKB1 PPARG SMC1A MMRN2 ZMYND11 PDS5B PDS5A ACTN2 WAPAL SIRT4 SH2D4B FAM25A DNAJB13 ADIRF LDB3 GHITM CDHR1 SMC3 DYDC2 RGR GPR15LG BMP2 SNCG RAD21 SUSD2 MAS1 TSPAN14 TNFSF11 LRIT2 ETHER LIPID BIOSYNTHESIS%WIKIPATHWAYS_20260610%WP5275%HOMO SAPIENS Ether lipid biosynthesis GNPAT LPCAT1 LPIN2 PEX16 PEDS1 CEPT1 LPIN3 ALDH3A2 PEX7 PEX5L DHRS7B AGMO ACAD10 PEX19 UGT8 PEX3 LPIN1 FAR1 METABOLISM OF SPHINGOLIPIDS IN ER AND GOLGI APPARATUS%WIKIPATHWAYS_20260610%WP4142%HOMO SAPIENS Metabolism of sphingolipids in ER and Golgi apparatus SPHK1 SGMS2 SGPP1 B3GALT2 UGCG B3GALT1 SGPP2 KDSR CERS3 CERK GALNT16 SGMS1 B4GALT2 UGT8 B4GALT1 B4GALNT1 SGPL1 SPHK2 GALNT1 IL10 ANTI INFLAMMATORY SIGNALING%WIKIPATHWAYS_20260610%WP4495%HOMO SAPIENS IL10 anti inflammatory signaling IL10RB STAT2 IL10RA HMOX1 IL6 HEL-S-10 IL10 IL1A STAT1 JAK1 STAT3 MFAP5 MEDIATED OVARIAN CANCER CELL MOTILITY AND INVASIVENESS%WIKIPATHWAYS_20260610%WP3301%HOMO SAPIENS MFAP5 mediated ovarian cancer cell motility and invasiveness TNNC1 PLCG1 JUN MAPK1 PRKCQ MFAP5 ITGB3 MAPK3 ITGAV CREB1 RYR3 GPR40 ROLE IN INSULIN SECRETION%WIKIPATHWAYS_20260610%WP3958%HOMO SAPIENS GPR40 role in insulin secretion PLCG1 PKD1 PLCE1 PLCB3 GNA11 PLCH1 FFAR1 PLCG2 PLCD3 PLCB1 PLCB2 PLCL1 SMC1 SMC3 ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260610%WP5118%HOMO SAPIENS SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome PAXIP1 RAD50 BRCA1 RAD18 NBN SMC3 MDC1 SMC1A RAD21 MRE11A ATM FRAGILE X SYNDROME%WIKIPATHWAYS_20260610%WP4549%HOMO SAPIENS Fragile X syndrome CAMK2A SH3GL3 SOS1 TTI1 ALDH3A2 PRKAR1A CREB1 AGAP2 PLCB1 SYNGAP1 DEPTOR DKFZp762B153 ABCD3 KCNC1 SH3GL1 KCND2 GRIP2 AKT1S1 TBC1D7 MAPK1 EIF4EBP2 EPS8L1 ARHGAP32 ARAF CNR1 CDKN2A SHANK1 PTPN11 MTOR ALDH5A1 EIF4A1 ABAT AP2M1 EPHA4 PPP2R5B GRIA2 AP2S1 HCN1 SRC FYN EIF4E MMP9 HOMER1 RPS6KB1 PLCG1 GRIN2B CYFIP1 FMR1 DLG4 PRKCA GABRB2 APP PPP3CA ARC MAP1B AP2A1 MAP2K1 NF1 DUSP3 EIF4G1 MAP2K2 SHC1 CPT1A TSC2 TSC1 MLST8 DLGAP3 RAF1 EEF1A1 NTRK2 PICK1 AKAP5 CAMK1 DAG1 PTPN5 CLTCL1 GPHN DICER1 RHEB GRIP1 GRB2 CYFIP2 GAD1 CLTC CLTB PTEN CLTA GRIN1 CAMK4 RPTOR RAP1GAP TARBP2 BDNF AGO2 WHITE FAT CELL DIFFERENTIATION%WIKIPATHWAYS_20260610%WP4149%HOMO SAPIENS White fat cell differentiation IRF4 NR3C1 KLF2 KLF4 CREB1 RORA ZNF423 NR2F2 CTNNA1 CEBPB FOXO1 CEBPD EVI1 TLE3 PPARG WNT10B GATA2 GATA3 CEBPA INS EGR2 IRF3 STAT5B KLF15 TCF7L1 NR1H3 DDIT3 KLF5 RARA POLYOL PATHWAY%WIKIPATHWAYS_20260610%WP690%HOMO SAPIENS Polyol pathway SORD AKR1B1 KHK ALDOB STEROIDOGENIC PATHWAY%WIKIPATHWAYS_20260610%WP4463%HOMO SAPIENS Steroidogenic pathway STAR HSD17B1 HSD3B1 CYP17A1 CYP11A1 METABOLIC PATHWAY OF LDL HDL AND TG INCLUDING DISEASES%WIKIPATHWAYS_20260610%WP4522%HOMO SAPIENS Metabolic pathway of LDL HDL and TG including diseases SCARB1 LIPG MTTP ANXA2 LIPC APOB LDLR ABCA1 APOA2 LPL APOC2 APOE PCSK9 PATHWAYS AFFECTED IN ADENOID CYSTIC CARCINOMA%WIKIPATHWAYS_20260610%WP3651%HOMO SAPIENS Pathways affected in adenoid cystic carcinoma ARID1A PIK3CA NOTCH1 MYB MAML3 UHRF1 SETD2 JMJD1C NCOR1 HIST1H1E CMTR2 ARID5B SMARCE1 NFIB MAGI1 HIST1H2AK INSRR FOXP2 BCOR MORF4L1 BCORL1 KMT2C KAT6A MYCBP EP300 SRCAP DTX4 MGA KANSL1 CEBPA CREBBP FGFR4 MYBL1 FGF16 ERBB2 ARID4B CHEK2 MYC CHEK1 MAP2K2 ERBIN TLK1 FOXO3A RAF1 SMC1A PRKDC CTBP1 KDM6B ATM FBXW7 PTEN BRCA1 HRAS MAX WNT BETA CATENIN SIGNALING INHIBITORS IN CURRENT AND PAST CLINICAL TRIALS%WIKIPATHWAYS_20260610%WP5442%HOMO SAPIENS Wnt Beta catenin signaling inhibitors in current and past clinical trials LRP5 CREBBP LRP6 PORCN ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20260610%WP528%HOMO SAPIENS Acetylcholine synthesis ACHE PDHA1 ChAT PEMT PDHA2 CHKA GLYCEROLIPIDS AND GLYCEROPHOSPHOLIPIDS%WIKIPATHWAYS_20260610%WP4722%HOMO SAPIENS Glycerolipids and glycerophospholipids DGKZ GPAM AGPAT4 PTDSS1 GPAT4 PEMT CDS1 CHKB PCYT2 PTDSS2 PNPLA2 CRLS1 DGAT1 CHPT1 PLA2G1B PISD PNPLA3 CDIPT DGAT2 MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY WITH INHIBITORS%WIKIPATHWAYS_20260610%WP4189%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway with inhibitors HMGCR MVD ATR SIGNALING%WIKIPATHWAYS_20260610%WP3875%HOMO SAPIENS ATR signaling TOPBP1 ATR RAD1 RAD9A HUS1 ATRIP RPA1 RPA3 RAD9B CHEK1 HEMATOPOIETIC STEM CELL DIFFERENTIATION%WIKIPATHWAYS_20260610%WP2849%HOMO SAPIENS Hematopoietic stem cell differentiation CD34 CSF3 NCKAP1L NOTCH1 EPO MYB IL1B GP9 LYL1 ACVR1B CSF2 CSF1 CXCR4 SPI1 MHC2TA PIM1 KLF1 MUC1 RUNX1 ITGA2B TRAF3IP3 IKZF1 HMGN5 LEF1 TRIM29 TPO CBFA2T3 ZNF835 VAV1 ABO MXI1 NFE2 RIOK3 FLI1 IL3 FOSB NFATC2 IL6 ARHH HES6 LMO2 GATA1 GATA2 IL5 NR1A2 XB ITGB3 IL1A FOS KITLG FAMILIAL HYPERLIPIDEMIA TYPE 1%WIKIPATHWAYS_20260610%WP5108%HOMO SAPIENS Familial hyperlipidemia type 1 ANGPTL3 LIPC LDLR PLTP SEL1L GPIHBP1 APOA2 LMF1 APOA4 APOA5 LPL APOC2 ANGPTL4 SEBALEIC ACID FORMATION AND METABOLISM%WIKIPATHWAYS_20260610%WP5315%HOMO SAPIENS Sebaleic acid formation and metabolism FADS1 ALOX5 CYP4F3 FADS2 ACSL1 CANCER PATHWAYS%WIKIPATHWAYS_20260610%WP5434%HOMO SAPIENS Cancer pathways RARB HES5 RPS6KA5 GNAS VEGFB VEGFC HES1 DCC CXCL8 CAMK2D GNGT1 GNGT2 GSTT2 PRKACG EP300 IL6R IFNAR2 ARHGEF1 TRAF2 TRAF3 TRAF6 TRAF5 GNAI3 IFNAR1 HDAC2 GNG3 GNG10 GNG5 GNG4 GNG7 GNG8 GNG12 FADD GNG11 HEY2 GNG13 GNB2 SKP1 GNB1 STAT2 GNB5 IL6 CXCL12 TGFA IL13RA1 ALK KPG_010 POLK EML4 PDGFA LPAR2 LPAR3 RXRB IGF2 RXRG IFNA5 IFNA4 IFNA7 IL4 NFKBIA IFNA6 IFNA1 IFNA2 IFNA8 ITGAV RAC1 KITLG ITGA6 CSF3R EPO IFNA13 IFNA14 IFNA16 IFNA17 ARHA COL4A3 COL4A5 IFNA10 CXCR4 IFNA21 EGFR ARNT2 IL7 GNB4 IL7R ITGA2B HSP90AB1 FLT4 IL3RA COL4A2 MSH3 COL4A1 GNG2 COL4A4 COL4A6 LAMB4 EPOR PRKCB RBX1 GSK3B WNT2B FZD10 PIK3R3 PIK3R2 WNT5B WNT9B PIK3R1 WNT9A FOXO1 NRAS LAMC2 WNT16 WNT8A LAMC1 WNT8B RAC3 WNT3 WNT4 WNT10B WNT10A FZD3 FZD5 FZD4 WNT7B FZD9 BIRC2 WNT7A BIRC3 LAMA5 ROCK1 CAMK2G LAMA1 ROCK2 LAMA4 LAMA3 FRAT1 CTBP1 LAMB3 LAMB2 LAMB1 VEGFD KNG1 BDKRB2 LPAR4 BDKRB1 JAG2 NOTCH1 LPAR1 AXIN2 DLL3 DLL4 IL23A PTCH1 BCL2L11 PIK3CD CKS1B IL2 CBL FH STAT4 RPS6KB1 SKP2 BBC3 CCDC42 E2F2 CCND3 CCND2 MGST3 MGST2 APAF1 CCDC6 DDB2 CCNE2 CCNE1 GSTM5 PMAIP1 GADD45B GADD45A PML MGST1 GADD45G CDK6 RAD51 CYCS GSTA5 F2R GSTA4 GSTA3 F2 IFNG PAX8 NCOA1 RXRA SPI1 FLT3 ARAF NR1C2 IKBKB AKT3 PIM1 PIM2 IKBKG CHUK RUNX1 CCNA2 KIT SOS2 CEBPA CSF1R LEF1 RELA RUNX1T1 STAT5B TCF7L2 TCF7L1 JUP ZBTB16 IL3 RPS6KB2 BRCA2 IGF1R PRKCA ERBB2 PLCG2 FGFR1 NFE2L2 PPARG IL5RA IL2RG IL5 IL2RA IL2RB NOS2 IL12B IL12A IL13 TNFSF6 MAX MAPK10 PLCB3 PLCB4 PLCB1 PLCB2 ITGB1 ITGA2 EVI1 TRAF1 IL6ST TFG PLEKHG5 JAK3 HHIP EDNRA EDNRB SMAD4 ARHGEF11 RASGRP4 RASGRP3 BCL2L1 MMP3 TGFBR1 MAPK9 FRAT2 Em:AP000351.3 IL15RA GSTM1 HMOX1 GSTM4 CTNNA1 CTNNA3 CTNNA2 CTBP2 PTGER1 PTGER2 IFNGR1 PTGER3 IFNGR2 DVL3 CALML6 CALML3 CALML4 IL12RB1 TPR CSF2RB CSF2RA NOTCH2 AGTR1 F2RL3 RALB DVL1 HDAC1 FZD2 CAMK2A SUFU EGLN3 PTCH2 TGFBR2 EGLN2 KIF7 ELOC BIRC7 GNA13 E2F3 APC WNT3A VHL NTRK1 FGFR4 RB1 CRKL CCND1 ARHGEF12 MYC MAP2K1 MAP2K2 GSTM2 HGF FZD7 MSH6 AXIN1 MSH2 FZD8 RAF1 DVL2 KLK3 SMAD2 JUN GNA11 CDK4 SP1 CDK2 BCL2 MDM2 HEL-S-21 GRB2 CDKN1A LRP5 CDKN1B PTEN LRP6 CASP9 CASP8 CASP3 HEL-S-125m APPL1 HRAS JAK1 FZD1 FOS NOTCH3 NOTCH4 PIK3CA SOS1 NQO1 CRK KEAP1 BCR MAPK8 MAPK1 MAPK3 CDKN2B BAD STAT1 CDKN2A STAT3 GNAI1 MTOR TERT BAX ADCY3 ADCY1 RALBP1 FLT3LG ADCY8 ADCY6 PLD2 ADCY5 ADCY9 PDGFRA RALA CREBBP EDN1 TXNRD2 HIF1A VEGFA PLCG1 FGFR2 APC2 RASSF1 EGF MMP2 DAPK2 IGF1 BIRC5 NFKB1 NFKB2 NR3A2 GSTM3 TPM3 FGFR3 RET HEL-S-22 GLI3 SHH GNB3 TGFB1 BAK1 EGLN1 TRAF4 NKX3-1 PTGER4 BMP4 BMP2 PTGS2 WNT1 SMO RARA RIOK1 AND RIOK2 IN EGFR AND PI3K MEDIATED TUMORIGENESIS%WIKIPATHWAYS_20260610%WP3873%HOMO SAPIENS RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis MTOR PIK3CA PTEN RPL11 RICTOR MLST8 FOXO3A EGFR RIOK2 RIOK1 MAPKAP1 AKT3 TAMOXIFEN METABOLISM%WIKIPATHWAYS_20260610%WP691%HOMO SAPIENS Tamoxifen metabolism CYP1A2 UGT1A4 CYP1A1 UGT2B7 CYP1B1 UGT1A8 CYP3A4 UGT1A10 CYP2C19 CYP2C9 CYP2A6 CYP2E1 SULT1A1 SULT1E1 SULT2A1 UGT2B15 ULCERATIVE COLITIS SIGNALING%WIKIPATHWAYS_20260610%WP5174%HOMO SAPIENS Ulcerative colitis signaling IL5 NFATC1 GATA3 IL10 HLA-DMA MAF IL4 TGFB1 IL13 FOXP3 NFKB1 NOD2 IFNG IL2RG TNF OXYTOCIN SIGNALING%WIKIPATHWAYS_20260610%WP2889%HOMO SAPIENS Oxytocin signaling OXTR BLOOD CLOTTING CASCADE%WIKIPATHWAYS_20260610%WP272%HOMO SAPIENS Blood clotting cascade F10 SERPINB2 PLAT F3 F13B FGA F7 F11 PLG SERPINF2 F2 KLK1 HEL-S-78p F5 VWF F8 F9 KLKB1 NETWORK MAP OF SARS COV 2 SIGNALING%WIKIPATHWAYS_20260610%WP5115%HOMO SAPIENS Network map of SARS CoV 2 signaling DDIT4 EGR1 NEK9 CXCL6 CXCL9 IFITM1 CXCL8 TLE3 CXCL1 CXCL13 CXCL3 CXCL2 TNF CXCL5 CCR6 TBK1 IL10 TRAF2 ACE2 IL1R2 IRF3 IFIH1 APOA2 TRAF3 RRM2 TRAF6 APOC1 IL8RB IL9 LARP1 CCL5 CCL4 CCL3 CCL2 IFITM3 HEL117 GTSE1 VPS36 IFNB1 WDR74 IFI27 CD226 MX1 APOM ITCH HEL103 MAVS HRG IL6 CTSZ SERPINA10 TP53I3 EIF4A2 MMP25 SDF2 CXCL12 IL16 RIGI HMFT1766 PF4 OS9 SRP19 HP CLCC1 GTF2F2 HEL-S-72p UGCGL2 G3BP2 NPTX1 VPS18 MDN1 GABARAPL2 TRO VPS33A TRIM59 ITIH3 ATE1 RPS6 TBKBP1 ATP13A3 FAM98A INTS4 VPS16 HLA-DRB5 ITIH4 BST2 IL4 TNFSF10 HLA-DRB1 MIB1 CTSL C1QBP RAC1 IL22 MOV10 IL1B DKFZp762B153 CCR5 VPS41 GP1BA LGALS3BP RRAS CCL11 IL7 CXCR1 CCL15 IL33 CCL22 CCL21 PRG3 CCL27 CCL26 IL-21 CXCL16 IL18RAP DKFZp781O1323 IFI6 LBP APOL1 MLST8 COQ8B HEL-S-81p ULK1 HBD CCL8 RTN4 CCL1 FAM83A C1S CFP C8A CFB TGFBR2 CFH CFI SRP54 PIAS1 ZAP70 LCK JUNB IRF9 OAS2 NTRK1 FYN EIF4E PTPN6 TOMM70 CARD11 FGA HEL-S-78p ALB SAA1 SAA2 EIF4EBP1 CCNB2 JUN CCNB1 CDC2 RHEB AHR NRF CD2 RPTOR IL18 CASP9 CASP8 CASP3 JAK1 IRAK1 IFNG PARP2 NLRP3 FOS GGH MYD88 IFIT1 CD163 DEPTOR CPN1 MAPK8 AKT1S1 STAT1 CRP IKBKG MTOR PMPCB APOH STEAP3 TPO CD14 TRPM2 PITRM1 SMAD1 FGF2 HIF1A ADAM9 NFATC3 APOD CD3G PRKCQ CD3E IGLL1 CD8B CD8A HEL-S-130P NLRP1 BIRC5 CEBPB SELP NFKB2 IL5 HBB TF IL12A ACTG1 CASP5 CCL20 PS1TP5BP1 IL13 CAMK4 IL17A IL1A PTGS2 MIR 509 3P ALTERATION OF YAP1 ECM AXIS%WIKIPATHWAYS_20260610%WP3967%HOMO SAPIENS miR 509 3p alteration of YAP1 ECM axis TEAD2 SPARC PBX3 TEAD3 TEAD4 THBS2 COL1A1 SNAI2 YAP1 TWIST1 EDNRA GPC6 COL3A1 ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY%WIKIPATHWAYS_20260610%WP2118%HOMO SAPIENS Arrhythmogenic right ventricular cardiomyopathy ITGA6 ITGA1 DSG2 ITGB1 CTNNA1 CTNNA3 CTNNA2 ITGA4 ITGA2 ITGB7 RYR2 ITGA2B GJA1 CDH2 CACNA2D3 LEF1 CACNA2D2 CACNA2D4 EMD CACNB1 TCF7L2 SGCA CACNB3 TCF7L1 CACNB4 JUP DSC2 CACNA1F CACNA1S PKP2 SLC8A1 ITGB4 ITGB8 ACTN1 ITGB6 CACNG6 CACNG7 DMD CACNG1 CACNG3 CACNA1C CACNG4 ACTN2 ITGA7 CACNG5 DAG1 CACNG8 ACTN4 DES CACNG2 SGCD SGCB SGCG ACTG1 PS1TP5BP1 LMNA CACNA2D1 ITGB3 ITGAV ATP2A2 NANOMATERIAL INDUCED INFLAMMASOME ACTIVATION%WIKIPATHWAYS_20260610%WP3890%HOMO SAPIENS Nanomaterial induced inflammasome activation TLR4 NFKB1 IL1B PYCARD BIOMARKERS FOR UREA CYCLE DISORDERS%WIKIPATHWAYS_20260610%WP4583%HOMO SAPIENS Biomarkers for urea cycle disorders F10 F7 OTC ASL NAGS GPT HEL-S-20 ASS1 ARG1 GLS2 MITOCHONDRIAL COMPLEX IV ASSEMBLY%WIKIPATHWAYS_20260610%WP4922%HOMO SAPIENS Mitochondrial complex IV assembly COX7A2 COX5A COX3 SURF1 COX19 COX16 COX18 TACO1 COX7B HIGD1A PET117 COX14 COA6 COX10 COX6A1 COX2 PET100 COX7C COX1 FAM36A CMC1 TMEM177 PNKD COA3 SMIM20 COX17 COX8A COXFA4 COX11 COX6B1 FTO OBESITY VARIANT MECHANISM%WIKIPATHWAYS_20260610%WP3407%HOMO SAPIENS FTO obesity variant mechanism UCP1 TBX1 PPARGC1A PRDM16 IRX5 IRX3 ARID5B CANONICAL AND NON CANONICAL TGF B SIGNALING%WIKIPATHWAYS_20260610%WP3874%HOMO SAPIENS Canonical and non canonical TGF B signaling MAPK14 BMP1 SMAD2 BMPR2 TGFBR2 BMPR1A LOXL1 MAPK9 LOXL2 TGFB1 GREM1 MAPK8 TGFBR1 SMAD4 LOXL4 TRYPTOPHAN KYNURENINE PATHWAY IN POST COVID SYNDROME%WIKIPATHWAYS_20260610%WP5549%HOMO SAPIENS Tryptophan kynurenine pathway in post COVID syndrome IFNB1 GOT2 HAAO IL6 TDO2 DDC AFMID AHR KYAT3 KYAT1 IDO2 IL1B IFNA6 KYNU KMO AADAT IFNG TNF IDO1 PRIMARY OVARIAN INSUFFICIENCY%WIKIPATHWAYS_20260610%WP5461%HOMO SAPIENS Primary ovarian insufficiency BMPR1A SALL4 DAZL GNAS FOXL2 NR5A1 WT1 SOX8 FIGLA DMC1 MST1R ZP3 STAR ALOX12 POLR2C RECQL4 WRN TP63 FANCA RFWD3 ERAL1 POLR3H ZAR1 FSHR NUP107 PPM1B NBN BLM COX10 LARS2 STAG3 RAD51 ATM PRORP ANTXR1 MEIOSIN POF1B MEIOB SIL1 NANOS3 PREPL NOBOX AARS2 AIRE HMMR WDR62 SYCE1 SOHLH1 KASH5 TGFBR3 SOHLH2 SLX4 SWI5 HELQ DIAPH2 H1-8 HROB LHX8 MCMDC2 ELAVL2 BNC1 EIF2B1 C1orf146 DCAF17 MRPS22 SPIDR HSD17B4 SIX6OS1 HAX1 CYP17A1 PCCA PCCB PSMC3IP HSD17B1 CCDC185 EIF2B2 MGME1 C10orf2 MND1 NLRP11 XPNPEP2 SPATA33 FANCM FANCL CLPP PGRMC1 AMHR2 BRCA2 FMR1 MCM9 CENPE EIF4ENIF1 ATG9A BMP6 LAMC1 NR3A2 BMP15 AMH POLG NOTCH2 BMPR2 KHDRBS1 LMNA MSH4 MSH5 EIF2B5 STRA8 HIPPO YAP SIGNALING%WIKIPATHWAYS_20260610%WP4537%HOMO SAPIENS Hippo YAP signaling WWTR1 MAP4K2 MINK1 TEAD2 RASSF1 TEAD3 TEAD4 LATS1 MAP4K3 LATS2 NF2 YAP1 TNIK MAP4K1 HEL-S-31 STK38L GANGLIO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260610%WP5299%HOMO SAPIENS Ganglio series sphingolipid metabolism B4GALNT1 NEU4 HEL-S-111 ST8SIA1 HEXA B3GALT4 ST8SIA5 NEU3 ST3GAL5 ST8SIA6 SIAT4C ST3GAL1 ROS IN COVID 19 ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260610%WP5258%HOMO SAPIENS ROS in COVID 19 endothelial dysfunction IFNA1 IFNAR1 NFKB1 ACE2 TNF TNFRSF1A ESTROGEN SYNTHESIS AND METABOLISM%WIKIPATHWAYS_20260610%WP5276%HOMO SAPIENS Estrogen synthesis and metabolism HSD17B8 CYP1A2 CYP3A7 UGT2A2 UGT2B7 CYP1B1 UGT1A8 CYP3A4 HSD17B3 HSD17B4 UGT1A10 HSD17B7 CYP2C19 CYP2C9 HSD17B1 HSD17B2 HSD17B10 SULT1E1 FEMALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260610%WP5318%HOMO SAPIENS Female steroid hormones in cardiomyocyte energy metabolism ACLY MTTP ACADM SLC2A4 APOB PPARGC1B NR1C1 ESRRA HADHB STK11 RETINOID METABOLISM IN RETINA HEALTHY VS RLBP1 DEFICIENT%WIKIPATHWAYS_20260610%WP5532%HOMO SAPIENS Retinoid metabolism in retina healthy vs RLBP1 deficient RLBP1 GASTRIC CANCER NETWORK 2%WIKIPATHWAYS_20260610%WP2363%HOMO SAPIENS Gastric cancer network 2 DGIC TOP2A RFC3 RFC4 MYC S100A6 UBE2C OTUD5 CEBPZ EGFR CHTF18 DSCC1 CHTF8 BRIX1 ATAD2 AHCTF1 CACYBP FAM91A1 RNF144B CD48 COL9A1 COL9A3 UBE2T LMNB2 LBR MTDH RAD17 SNURF DIRECT REVERSAL REPAIR%WIKIPATHWAYS_20260610%WP4931%HOMO SAPIENS Direct reversal repair ALKBH3 ALKBH2 NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20260610%WP299%HOMO SAPIENS Nuclear receptors in lipid metabolism and toxicity CYP1A2 RARB NR1i1 ABCC3 ABCB4 CYP3A4 NR1I3 ABCC2 ABCB1 CYP8B1 ABCG5 NR1i2 NR1H4 ABCG1 ABCB11 CYP2C9 ABCD3 CYP2E1 CYP2B6 CYP27B1 CYP24A1 PPARG NR1C2 CYP26A1 ABCD2 CYP7A1 ABCA1 NR1H3 NR1B3 CYP4A11 NR1C1 RARA ACUTE VIRAL MYOCARDITIS%WIKIPATHWAYS_20260610%WP4298%HOMO SAPIENS Acute viral myocarditis CASP2 CCR3 SOS1 HLA-DMA CREB1 HEL-S-28 MICA CCR5 MAPK1 CXCR4 MAPK3 STAT1 TNF STAT3 BAX IL10 CAAP1 CXADR CHRAC1 BNIP2 IL2 SGCA NOD2 SOCS1 EDN1 SRC FYN MMP9 BCL2L1 IL6 CCND1 GSK3B EIF4G1 PYCARD PABPC1 PIK3R1 TLR4 NFKB2 RAC3 DMD CD80 DAG1 CD40LG AIF1 AAG1 TICAM1 SGCD MYH6 SGCB IL12B IL12A SGCG TLR5 BCL2 TLR3 CASP6 PS1TP5BP1 ABL2 TGFB1 CYCS DFFB CASP9 DFFA CASP8 CASP3 CD55 JAK1 IFNG FLUOROACETIC ACID TOXICITY%WIKIPATHWAYS_20260610%WP4966%HOMO SAPIENS Fluoroacetic acid toxicity ALDH9A1 CS ALDH3A2 ALDH2 ACSS2 ACO2 BASE EXCISION REPAIR%WIKIPATHWAYS_20260610%WP4752%HOMO SAPIENS Base excision repair SMUG1 LIG1 RFC2 POLE RFC3 RFC4 PCNA TDG NEIL2 POLG POLL RFC1 FEN1 POLD3 POLD4 POLD2 HMGB1 PARP4 APTX APEX1 MPG OGG1 PNKP UNG POLE4 NTHL1 MUTYH MBD4 PARP3 ADPRHL2 NEIL3 POLG2 TDP1 NEIL1 POLE2 POLE3 PARP2 MITOCHONDRIAL LONG CHAIN FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260610%WP368%HOMO SAPIENS Mitochondrial long chain fatty acid beta oxidation ACADVL ACSF2 CPT2 ACADL EHHADH SLC25A20 ACADS CPT1A ACADM PECR ACSL1 FACL4 ACSL3 RAS SIGNALING%WIKIPATHWAYS_20260610%WP4223%HOMO SAPIENS Ras signaling MAPK10 HTR7 GNGT1 GNGT2 PLA2G4B ARF6 PRKACG PLA2G5 PIK3CD GAB2 ZAP70 GNG3 GNG10 GNG5 NTRK1 GNG4 STK4 GNG7 GNG8 RASGRP4 GNG12 RASGRP3 GNG11 GNG13 BCL2L1 FGFR4 GRIN2B GNB2 REL KSR2 GNB1 GNB5 RASGRF2 PLA1A MAP2K1 PLA2G4F AFDN MAP2K2 SHC2 PLA2G4D SHC3 LAT PLA2G4E SHC1 PLA2G4C RRAS2 KSR1 PLA2G1B RAF1 NTRK2 RAB5B TIAM1 RAB5C RAP1A PLCE1 EPHA2 MAPK9 GRB2 ABL2 CALM1 RAB5A GRIN1 NGFR HRAS RAC1 RASA2 PIK3CA SOS1 PLA2G6 CDC42 SYNGAP1 ARHA MAPK8 PAK1 RAPGEF5 MAPK1 MAPK3 FLT3 EGFR BAD IKBKB CALML6 AKT3 RRAS CALML3 PTPN11 CALML4 RASA3 IKBKG GNB4 CHUK KIT FLT4 SOS2 CSF1R RALBP1 RIN1 RELA PLD2 PDGFRA RALA SHOC2 GNG2 FLT1 PLA2G3 RASAL1 SHC4 RASAL3 IGF1R TTBK1 KDR RGL2 PLA2G12A PRKCB PLCG1 RASA4B FGFR2 PLA2G12B PLAAT3 RASA4 PRKCA PLA2G2F PLA2G2D PLA2G2E RASSF1 PLA2G2C PLCG2 NF1 FGFR1 PIK3R3 PIK3R2 ETS2 FOXO4 PIK3R1 RASGRF1 NRAS INSR NFKB1 RAC3 FGFR3 PAK6 PAK4 GNB3 EXOC2 RALB PLA2G10 TNFSF6 PLA2G2A LEPTIN INSULIN SIGNALING OVERLAP%WIKIPATHWAYS_20260610%WP3935%HOMO SAPIENS Leptin insulin signaling overlap IRS4 DGKZ PDPK1 IRS1 INS PIK3R3 INSR SOCS3 SOCS1 LEP STAT3 SOCS2 LEPR DDX1 AS A REGULATORY COMPONENT OF THE DROSHA MICROPROCESSOR%WIKIPATHWAYS_20260610%WP2942%HOMO SAPIENS DDX1 as a regulatory component of the Drosha microprocessor RAD50 DDX1 DGCR8 DROSHA NBN MRE11A ATM GDNF RET SIGNALING AXIS%WIKIPATHWAYS_20260610%WP4830%HOMO SAPIENS GDNF RET signaling axis SOX11 LHX1 TCF2 HOXC11 ROBO2 ROBO1 WT1 RET FOXC1 GATA3 HOXD11 SLIT2 GLI3 SPRY1 HOXA11 FOXC2 FAT4 SALL1 SIX2 GREM1 SOX17 EYA1 AGTR2 PAX2 ALDH1A2 BMP4 IFT27 IFT25 GDNF GPCRS OTHER%WIKIPATHWAYS_20260610%WP117%HOMO SAPIENS GPCRs other UTS2R HTR7 CCR5 C5AR2 CCR2 CCKBR CNR1 CXCR1 S1PR1 ADRA1D CELSR2 ADRB2 IL8RB EDNRA ALG6 CXCR3 HTR2A OR1G1 FSHR CHRM2 OR2M4 GPR61 GPR62 GRPR CELSR3 RXFP3 GPR176 GPR132 GNRHR GPR135 ADGRV1 GHRHR OR1F1 OR2H1 TAAR5 OR1J2 TAAR2 HTR1F ADGRL2 OR1N1 ADGRL3 GPR162 OR1R1 OR5AC2 ADGRF5 GPR83 VN1R1 OR10A2 OR6C3 OR3A3 OR6C2 OR10A5 OR3A1 CELSR1 OR8G1 OR1E1 GPR88 GPR84 MCHR2 OR2B6 NTSR1 OR5D3 GPR183 P2RY13 GPR17 OR2F1 P2RY11 GPR55 CHRM3 EMR3 ADGRD1 GPR143 OR2A5 LGR6 F2R OR2A4 GPR18 DRD3 OR7E24 ADORA2A DRD4 SSTR2 PTGFR SMO INTERFERON MEDIATED SIGNALING%WIKIPATHWAYS_20260610%WP4558%HOMO SAPIENS Interferon mediated signaling IFNB1 IFNLR1 STAT2 PIK3CA PRKCA IFNA13 IFNA14 IFNA16 IFNA17 IFNW1 PIK3R1 IFNA10 IFNGR1 IFNA21 IFNGR2 STAT1 IFNK IFNL2 IFNL1 IFNAR2 IFNL3 IFNA5 IFNA4 IFNA7 TYK2 IFNA6 IFNA1 IFNA2 IFNA8 IL10RB IFNAR1 IRF9 IFNL4 IFNE JAK1 IFNG ANDROGEN RECEPTOR SIGNALING%WIKIPATHWAYS_20260610%WP138%HOMO SAPIENS Androgen receptor signaling KAT2B RNF6 KAT5 RNF4 BAG1 PATZ1 FHL2 TGFB1I1 CDC42 NCOA1 CREB1 FLNA ARHA SIN3A PSMC3IP UBE2I NCOR2 NCOR1 EGFR SMARCE1 STAT3 NR0B2 NR2C2 EP300 RAN TLE5 RELA PIAS1 ZMIZ1 HEL-S-99n CREBBP LIMK2 SRC SMAD4 RUNX2 TGIF1 SIRT1 CARM1 RB1 CCND1 GSK3B PIK3R2 PIK3R1 FOXO1 SUMO1 RLN1 UBE3A CCNE1 ROCK1 JUN ROCK2 SP1 KDM1A HEL-S-67p PAK6 MDM2 RAD9A PTEN BRCA1 ETV5 EFCAB6 STUB1 HEL32 KAT7 HDAC1 PIAS2 RHOB RAC1 ZNF318 SMIM40 FKBP4 EMBRYONIC STEM CELL PLURIPOTENCY PATHWAYS%WIKIPATHWAYS_20260610%WP3931%HOMO SAPIENS Embryonic stem cell pluripotency pathways BMPR1A NOG SMAD6 APC IL6ST SELENOP PIK3CD FGF8 MAP2K3 WNT3A SMAD4 MAP2K6 FGFR4 FGF16 MAP2K1 MAP2K2 FZD7 AXIN1 FZD8 RAF1 DVL2 PDGFA JUN FGF13 MDM2 GRB2 FGF12 MAPK7 MAPK6 ERAS MAPK4 ACTR2 LRP5 ACVR1 PTEN MAPK12 LRP6 HRAS JAK1 FZD1 LIF FOS SOS1 FGF3 FGF4 FGF6 FGF7 FGF9 HNF1A MAPK1 FGF20 FGF22 FGF21 FGF17 EGFR ARAF DVL3 STAT3 FGF14 AKT3 PTPN11 FGF19 FGF18 MTOR FGF10 PDGFRA SMAD1 FGF2 FGFR2 SMAD9 EGF MAP2K5 DKFZp781O1323 FGFR1 GSK3B WNT2B PIK3R2 WNT5B WNT9B WNT16 WNT3 WNT4 WNT10B WNT10A FZD3 FZD5 FGF23 FZD4 WNT7B FZD9 FGFR3 WNT7A BMPR2 ACVR2B BMP4 DVL1 WNT1 FZD2 INVOLVEMENT OF SECRETASE IN NEURODEGENERATIVE DISEASES%WIKIPATHWAYS_20260610%WP5372%HOMO SAPIENS Involvement of secretase in neurodegenerative diseases CEBPB BACE1 APP BDNF SRPK2 SET NTRK2 STAT1 TARDBP SNCA AKT3 GALANIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260610%WP4970%HOMO SAPIENS Galanin receptor pathway CRP IL6 POMC BCL2L11 CDKN1C CREB1 INS VAMP2 CDKN1A CDKN1B YAP1 SLC2A4 PPARG VEGFA FOS COLCHICINE METABOLIC PATHWAY%WIKIPATHWAYS_20260610%WP2536%HOMO SAPIENS Colchicine metabolic pathway CYP3A4 LTF DANGER SIGNAL RESPONSE PATHWAY%WIKIPATHWAYS_20260610%WP4478%HOMO SAPIENS LTF danger signal response pathway IFNB1 MYD88 IL6 IRAK4 AGER HEL110 IL1B TRAF6 CD14 IFNA1 TLR4 MAPK1 NFKB1 CXCL8 TREM1 IL1A IRAK1 TNF HINT1 PATHWAY%WIKIPATHWAYS_20260610%WP5523%HOMO SAPIENS HINT1 pathway GTF2H2C_2 CDK7 NFATC2 SH3RF1 JUN GTF2H2 KARS1 GTF2H3 GTF2H4 HINT1 GTF2H5 RUVBL2 ERCC2 MAPK9 MNAT1 NFKB1 USF2 RUVBL1 CCNH TCF4 FOS EUKARYOTIC TRANSCRIPTION INITIATION%WIKIPATHWAYS_20260610%WP405%HOMO SAPIENS Eukaryotic transcription initiation GTF2H2C_2 TBP POLR3H CDK7 POLR3K GTF2H2 TAF9 GTF2H3 GTF2E2 GTF2H4 GTF2E1 TAF12 HEL-S-28 ERCC2 TAF7 MNAT1 TAF6 POLR1A GTF2F2 POLR1D TAF5 POLR2A POLR2B POLR2C POLR2G POLR2H POLR2I POLR2J POLR2K POLR2F GTF2B POLR3B TAF13 POLR3D CCNH POLR3E GAMMA GLUTAMYL CYCLE FOR THE BIOSYNTHESIS AND DEGRADATION OF GLUTATHIONE%WIKIPATHWAYS_20260610%WP4518%HOMO SAPIENS Gamma glutamyl cycle for the biosynthesis and degradation of glutathione HEL-S-64p GGCT GCLC OPLAH 13Q12 OR CRYL1 COPY NUMBER VARIATION %WIKIPATHWAYS_20260610%WP5405%HOMO SAPIENS 13q12 or CRYL1 copy number variation HEL30 KLEEFSTRA SYNDROME%WIKIPATHWAYS_20260610%WP5351%HOMO SAPIENS Kleefstra syndrome ARID1A KMT2C ARID1B PAGR1 BAP1 SMARCA4 EHMT1 WDR5 SMARCD1 SMARCD2 SMARCD3 NCOA6 NR1I3 DPY30 MBD5 SMARCC1 SMARCC2 PAXIP1 H3F3B RXRA ASH2L ASXL1 ACTL6B ACTL6A OLIGODENDROCYTE SPECIFICATION AND DIFFERENTIATION LEADING TO MYELIN COMPONENTS FOR CNS%WIKIPATHWAYS_20260610%WP4304%HOMO SAPIENS Oligodendrocyte specification and differentiation leading to myelin components for CNS CNP MOG MYT1 NKX2-6 SOX6 SOX5 OMG OLIG2 IL1B SOX10 IGF1 ASCL1 CXCL1 SOX8 CXCL2 TNF MBP NKX2-2 SHH CNTF SOX9 BMP4 FGF2 BMP2 LIF OLIG1 CATALYTIC CYCLE OF MAMMALIAN FLAVIN CONTAINING MONOOXYGENASES FMOS %WIKIPATHWAYS_20260610%WP688%HOMO SAPIENS Catalytic cycle of mammalian flavin containing monooxygenases FMOs FMO4 FMO5 1Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260610%WP4905%HOMO SAPIENS 1q21 1 copy number variation syndrome GJA8 CHD1L GJA1 PRKAA2 PYGO1 GJA5 PRKAB2 NBPF12 PRKAB1 AFDN BCL9 F11R FMO5 PYGO2 PRKAA1 ACP6 AMELX TJP3 TJP1 PRKAG1 GJA3 PRKAG2 PRKAG3 GPCRS CLASS A RHODOPSIN LIKE%WIKIPATHWAYS_20260610%WP455%HOMO SAPIENS GPCRs class A rhodopsin like OPRK1 HCRTR2 HCRTR1 HTR4 HTR6 HTR7 DRD2 MAS1L LHCGR CCR6 IL8RB EDNRA EDNRB F2RL1 FSHR GPER DRD1 HTR1E HTR1F HTR1D HTR1B GHSR MC4R GPR83 KPG_010 CCR10 CCR1 XCR1 PTGFR PTGDR2 NPY2R TBXA2R PTGDR PTGIR CHRM1 OPN4 OPN3 ADRB3 CCR8 CCR7 CCR5 FFAR3 CCR4 CCR2 MC3R CXCR4 FPR1 PTGER1 PTGER2 PTGER3 CXCR5 HRH3 CXCR1 HTR2B HRH1 HRH2 DRD5 HTR5A ACKR3 GPR37 CXCR3 HTR1A HTR2A ADRA1A OXTR OR1G1 GRPR OR1F1 OR2H1 GPR87 OR3A3 CX3CR1 OR10A5 OR3A1 OR1E1 OR2B6 NTSR1 GPR17 GPR50 CNR2 OR2F1 ACKR4 AGTR1 CHRM3 AGTR2 CHRM4 F2RL3 CHRM5 OR2A4 GPR18 P2RY6 P2RY4 ADORA2A ADORA2B P2RY2 BDKRB2 P2RY1 LPAR4 BDKRB1 LTB4R C3AR1 OPN1SW OPN1MW OPN1LW RHO NPFFR2 C5AR2 RRH GPR174 GPR173 GPR171 CMKLR2 GPR37L1 FPRL2 TRHR OR1I1 MC2R GALR3 GALR2 NPBWR1 GALR1 NPBWR2 OR6B1 NTSR2 OR2J3 OR2J2 OR2J1 MC1R RGL4 OR6A2 OR7C2 OR7C1 GPR19 OR10J1 GPR27 GPR25 GPR22 BRS3 CCKAR FFAR2 GPR39 OR5F1 GPR34 GPR32 GPR31 AVPR1A OR5V1 OR3A2 OPRD1 OR10H1 OR10H3 GPR45 CCRL2 OR10H2 GPR42 OR2AG1 CHML GPR52 GPR4 GPR3 GPR6 MC5R OR1C1 GPR65 GPR63 OR2D2 NPY1R OR2T1 OR1A2 KPG_011 OR1A1 OR2C1 SUCNR1 OR5I1 MCHR1 OR2S2 HCAR3 FFAR1 OR1Q1 HCAR1 OR2B3 OR2B2 NMUR2 NMUR1 OR7A10 OR14J1 MLNR PRLHR OR8D2 OR7A17 NPY5R OR2H2 AVPR2 OPRM1 SSTR3 SSTR4 SSTR5 OR7A5 OR10A4 OR1E2 NPY4R OR8B8 OR2W1 OR12D3 OR1D5 OR1D2 OR2F2 F2R ACKR2 FPR2 OR11A1 CMKLR1 AVPR1B DRD3 DRD4 F2RL2 MAS1 CCR3 NMBR CCKBR CNR1 GPR85 ADRA1D ADRB1 ADRB2 ADRA2C ADRA2B ADRA2A MTNR1A MTNR1B CHRM2 GPR75 ADRA1B P2RY13 P2RY10 P2RY11 P2RY14 PTGER4 GPR161 SSTR2 NPFFR1 GPR68 CHOLESTEROL SYNTHESIS DISORDERS%WIKIPATHWAYS_20260610%WP5193%HOMO SAPIENS Cholesterol synthesis disorders CYP51A1 HMGCR EBP FDFT1 FDPS MVK DHCR24 PMVK DHCR7 LBR SQLE HMGCS1 SC5D MSMO1 HSD3B2 MVD HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES MAPK SIGNALING%WIKIPATHWAYS_20260610%WP4877%HOMO SAPIENS Host pathogen interaction of human coronaviruses MAPK signaling MAP2K4 MAPK10 IFI27 RPS6KA2 RPS6KA1 IFITM2 MAP2K1 MAP2K2 MAPK8 IFITM1 MAPK1 MAP3K10 MAPK3 ATF2 MAP3K11 RAF1 MAPK14 JUN MAP2K3 BCL2 MAPK9 BST2 JUNB DDIT3 MAPK12 MAPK13 MAPK11 EIF4E MAP2K6 IFITM3 MAP3K1 FOS TRANSLATION FACTORS%WIKIPATHWAYS_20260610%WP107%HOMO SAPIENS Translation factors EIF2AK1 EIF1AX SUI1 PAIP1 EIF5 EIF2S3 EIF4A2 EIF2B1 EIF3S2 EEF2K EIF3J EIF3G EIF3CL EIF2S2 EEF2 EIF3E EIF4G1 EIF3B PABPC1 EIF2B2 EIF4EBP2 EIF5B EEF1A1 EIF3S3 EIF6 EIF4EBP1 EIF3F EIF3D EIF4A1 EIF3A EIF5A EIF2AK2 EIF2S1 GSPT2 EEF1B2 EIF4H EIF4EBP3 EIF4E EIF2B3 EIF4B CLUH EIF1AY EIF2B5 EEF1G EEF1A2 ETF1 THERMOGENESIS%WIKIPATHWAYS_20260610%WP4321%HOMO SAPIENS Thermogenesis ARID1A ZNF516 MGLL KDM3B ARID1B SLC25A29 BMP8A SIRT6 SOS1 SMARCD1 SMARCD2 CREB1 SMARCD3 ADRB3 GNAS PRKAA1 AKT1S1 PPARGC1A FGF21 DPF1 DPF3 ACSL1 CNR1 ACSL6 SMARCE1 FACL4 ACSL5 ACSL3 PRKACG MAPK14 MTOR LIPE SOS2 ADCY3 PNPLA2 ADCY1 CPT2 MAP2K3 ADCY8 CREB3 ADCY6 SLC25A20 ADCY5 HEL-S-7a ADCY9 CREB5 BMP8B RPS6KB2 RPS6KB1 UCP1 RPS6KA6 RPS6KA2 RPS6KA1 FRS2 MAP3K5 PRDM16 PRKAB2 SMARCC1 PRKAB1 FGFR1 SMARCC2 CPT1A TSC2 GCG TSC1 NRAS MLST8 ATF2 RPS6 PPARG PRKAG1 CREB3L3 PRKAG2 PRKAG3 CREB3L4 CREB3L2 KDM3A SMARCA4 RHEB PRKAA2 KDM1A ACTG1 GRB2 PS1TP5BP1 CPT1C PLIN1 RPTOR MAPK12 MAPK13 MAPK11 PRKG1 HRAS ACTL6B ACTL6A CHOLESTEROL METABOLISM WITH BLOCH AND KANDUTSCH RUSSELL PATHWAYS%WIKIPATHWAYS_20260610%WP4718%HOMO SAPIENS Cholesterol metabolism with Bloch and Kandutsch Russell pathways ELOVL4 CYP46A1 GGPS1 FADS2 FDPS ABCG1 MVK HSD17B7 TM7SF2 PMVK DHCR24 DHCR7 ACAT2 MYLIP CYP27A1 HMGCS1 ELOVL5 NR1H2 FADS1 ACSL1 FACL4 ACSL3 CYP51A1 SCD HMGCR EBP FASN SREBF2 SOAT2 ABCA1 FDFT1 CH25H LBR SQLE SOAT1 SC5D MSMO1 NR1H3 ELOVL2 ELOVL3 MVD THYROID HORMONES PRODUCTION AND PERIPHERAL DOWNSTREAM SIGNALING EFFECTS%WIKIPATHWAYS_20260610%WP4746%HOMO SAPIENS Thyroid hormones production and peripheral downstream signaling effects ZNF516 MGLL PAX8 KDM3B TRH PIK3CA TTF2 SIRT6 NOTCH1 SLC5A5 TTF1 SOS1 NHSL1 DUOXA2 TG SECISBP2L DUOX2 DEHAL1 SLC26A4 ADRB3 RXRA AKT1S1 MAPK1 PPARGC1A FGF21 BAD SLC16A10 AKT3 DIO1 PFKFB2 MAPK14 MTOR ADCY3 PNPLA2 ADCY8 TPO CREB3 SRC RPS6KB1 UCP1 RPS6KA6 FRS2 POMC SLC16A2 PRDM16 MAP2K1 GSK3B FGFR1 TSC2 ITPR2 TSC1 FOXO1 AQP7 MLST8 ATF2 RPS6 PPARG RAF1 WNT4 THRA MC4R NPY AgRP TBC1D4 SLCO1C1 RHEB SHH KDM1A NR1A2 MDM2 GRB2 PLIN1 RPTOR ITGB3 NPPB CASP9 ITGAV HRAS TSHB MAPKAPK3 ACTL6B TSHR MAFA BREAST CANCER PATHWAY%WIKIPATHWAYS_20260610%WP4262%HOMO SAPIENS Breast cancer pathway HES5 JAG2 NOTCH1 AXIN2 DLL3 DLL4 CSNK1A1 HES1 E2F3 APC PGR PIK3CD FGF8 WNT3A HEY2 RPS6KB1 SKP1 FGF16 CSNK2A1 RB1 CCND1 MYC MAP2K1 MAP2K2 SHC2 SHC3 SHC1 E2F2 FZD7 AXIN1 FZD8 NBN SFRP4 RAF1 DVL2 DDB2 POLK JUN GADD45B GADD45A CDK4 SP1 GADD45G CDK6 FRAT2 GRB2 RAD51 ATM ATR CDKN1A LRP5 PTEN BRCA1 CSNK2A3 CSNK2A2 LRP6 HRAS FZD1 CSNK2B NOTCH3 FOS NOTCH4 PIK3CA SOS1 FGF3 FGF4 FGF6 FGF7 NCOA1 FGF9 CETN3 MAPK1 FGF20 FGF22 MAPK3 FGF21 FGF17 EGFR ARAF DVL3 AKT3 MRE11A FGF19 FGF18 MTOR RAD50 BAX FGF10 KIT FLT4 SOS2 LEF1 TCF7L2 TCF7L1 CSNK1A1L RPS6KB2 FGF2 SHC4 BRCA2 IGF1R APC2 ERBB2 EGF FGFR1 GSK3B WNT2B FZD10 PIK3R3 PIK3R2 IGF1 WNT5B PIK3R1 WNT16 NRAS NR3A2 NFKB2 WNT3 WNT4 WNT10B WNT10A FZD3 FZD5 FGF23 WNT7B FZD9 WNT7A NOTCH2 FRAT1 BAK1 DVL1 WNT1 FZD2 TNFSF11 TGF BETA RECEPTOR SIGNALING IN SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260610%WP4816%HOMO SAPIENS TGF beta receptor signaling in skeletal dysplasias TGFBR2 ADAMTSL2 pp6425 NOG SMAD6 SKI SKIL MAPK3 FBN1 FOXH1 STAT1 TNF STAT3 LTBP1 ENG EP300 LEF1 LEFTY1 SMAD1 CREBBP FKBP1A SMAD4 ZFYVE9 RUNX2 TGIF1 BAMBI INHBA LEFTY2 THBS1 SMAD9 EGF DKFZp781O1323 ZNF423 opn RUNX3 TGFBR1 NFKB1 ITGB6 SMAD2 JUN ZEB2 MAPK9 TGFB1 FST BMP4 HRAS JAK1 IFNG WNT1 LIF FOS TGFBR3 15Q11Q13 COPY NUMBER VARIATION%WIKIPATHWAYS_20260610%WP5407%HOMO SAPIENS 15q11q13 copy number variation KAT2B STXBP1 GJC2 SPEF1 SMC5 SMC6 SIN3A ANKRD32 ANKRD2 TJP3 GOLGA8T NSMCE3 NSMCE2 STX1B NSMCE1 GOLGA8K GOLGA8J TJP1 GJD3 MYZAP NECAB3 LYPD6 ENTREP2 UBN1 MLSN2 SLF2 CGN GJA1 CXADR FAN1 RELA CREBBP CANX CCL5 APP GOLGA8R KLF13 OTUD7A GOLGA8O GOLGA8Q MTMR10 TRPM1 GOLGA8H CHRNA7 FANCD2 CDC42BPB CALM1 STX1A HDAC1 NICOTINE EFFECT ON CHROMAFFIN CELLS%WIKIPATHWAYS_20260610%WP1603%HOMO SAPIENS Nicotine effect on chromaffin cells CHRNB4 CHRNA3 CACNA1C CACNA1G MET IN TYPE 1 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260610%WP4205%HOMO SAPIENS MET in type 1 papillary renal cell carcinoma PLCG1 PIK3CA RAPGEF1 SOS1 CRK PRCC CRKL CDC42 MAP2K1 STRN MAP2K2 PIK3R3 PIK3R2 MAPK8 PAK1 HGF PIK3R1 NRAS MAPK1 MAPK3 RAF1 BAD ARAF INSL3 STAT3 RAP1A AKT3 ALK PTPN11 C8orf34 JUN SOS2 PIK3CD PAK6 PAK4 GRB2 CDKN1A ELOA RPL11 CBL JAK3 SRC HRAS VEGFA KDR RAC1 AUTOSOMAL RECESSIVE OSTEOPETROSIS PATHWAYS%WIKIPATHWAYS_20260610%WP4788%HOMO SAPIENS Autosomal recessive osteopetrosis pathways CLCN7 OSTM1 TCIRG1 SNX10 TNFRSF11A NFKB1 RAB7A PLEKHM1 IKBKB TRAF6 TNFSF11 EPAC1 AND PKA REDUCTION OF RETINAL INFLAMMATION%WIKIPATHWAYS_20260610%WP5440%HOMO SAPIENS EPAC1 and PKA reduction of retinal inflammation PRKAR1B PRKAR1A IL1B NLRP3 APOPTOSIS RELATED NETWORK DUE TO ALTERED NOTCH3 IN OVARIAN CANCER%WIKIPATHWAYS_20260610%WP2864%HOMO SAPIENS Apoptosis related network due to altered Notch3 in ovarian cancer HSPD1 PKN1 CUL5 RNF7 THBS1 NQO1 ERBB3 APP GCLC SQSTM1 CTNNA1 HELLS BIRC5 MAPK1 PTK2B AXIN1 NFKB1 VAV3 NRG1 TRAF1 ERN1 TNF HEL-S-7 TNFRSF21 IL7R BEX3 YBX3 IER3 TNFRSF10B NET1 CARD14 CDKN1A CDKN1B HEL-S-102 F2R SOCS3 APOE JUND RIPK2 HEL-S-89n HDAC1 HEL113 RPS6KB1 TRANSCRIPTION ACTIVATION RNA POLYMERASE I AND KAT2A B AND INHIBITION NURD COMPLEX %WIKIPATHWAYS_20260610%WP5565%HOMO SAPIENS Transcription activation RNA polymerase I and KAT2A B and inhibition NuRD complex TBP KAT2B H2AC6 ASF1A H2BC12 CHD4 TAF12 TAF1B POLR1A MBD2 POLR1C POLR1D MBD3 MAPK3 RBBP4 H2AZ2 H2AB1 H2AJ CHD3 GATAD2B MTA2 EP300 SRCAP HAT1 ASF1B H3C15 PWWP2B PWWP2A KAT2A H3C8 RRN3 TAF1D GATAD2A H4C9 CDK2AP1 H3F3B HDAC2 CREBBP HIST1H4L UBTF H2AX H2AZ1 TLK2 H2AC19 H2AC14 H2BC26 H2BC12L H2BC21 HIST1H2AB SIRT7 H2BC17 H2BC13 H2BC14 H2BC15 H2BC11 HIST1H2BE EP400 H2BC9 H2BC8 H2BC3 H2BC1 H2AC20 HDAC1 BILE ACID SYNTHESIS AND ENTEROHEPATIC CIRCULATION %WIKIPATHWAYS_20260610%WP4389%HOMO SAPIENS Bile acid synthesis and enterohepatic circulation SLC10A2 FGF19 FXR1 MAPK1 MAPK3 LDLR ABCG8 CYP7A1 ABCG5 ABCB11 FGFR4 OMEGA 3 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260610%WP5432%HOMO SAPIENS Omega 3 fatty acids in senescence ALOX15 CYP1A2 EPHX2 ALOX12 HEL-S-22 ALOX15B PTGES GSTM4 CYP3A4 FADS2 CYP2C9 CYP2E1 ELOVL5 FPR2 FADS1 ELOVL2 GPR32 ALOX5 LTC4S PTGS2 PTGIS HPGD PTGS1 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260610%WP4249%HOMO SAPIENS Hedgehog signaling DHH SUFU ADRBK1 PTCH2 IHH KIF7 CCND1 SPOP CSNK1A1 SMURF1 KIF3A CCND2 BOC CSNK1G1 DKFZp686L0365 CDON PTCH1 PRKACG EVC GLI3 SHH BCL2 CSNK1G3 GAS1 hCG_2014051 SMURF2 FBXL17 CSNK1A1L SPOPL HHIP CSNK1G2 CSNK1D GPR161 EVC2 SMO CHOLESTEROL BIOSYNTHESIS WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260610%WP4804%HOMO SAPIENS Cholesterol biosynthesis with skeletal dysplasias CYP51A1 SC5D EBP DHCR24 DHCR7 LBR PROLINE AND HYDROXYPROLINE PATHWAYS%WIKIPATHWAYS_20260610%WP5026%HOMO SAPIENS Proline and hydroxyproline pathways PRODH CAMKK2 PATHWAY%WIKIPATHWAYS_20260610%WP4874%HOMO SAPIENS CAMKK2 pathway ATP1B2 HMOX1 GCK KEAP1 MAF MX2 CREB1 SELL DKFZp762B153 VCAM1 PAK1 MAPK1 MAPK3 SLCO3A1 TNF WDR35 PFKFB2 ACACA MTOR KLF1 EP300 FASN RELA TBXT ASNS STIM1 ARHGEF7 MS4A3 CCL5 IFGGE OASL ERMAP SIRT1 HIF1A GALNT9 MAMDC2 EPOR KDR MID1 ERAF RPS6KB1 SPINT1 SFI1 DGIC ATP10D NFATC2 TSPAN33 C1QTNF12 RHD ENHO SLC25A21 WFS1 CXCL11 CPOX CCND1 TMEM176B SQSTM1 TRPV4 AQP1 RHAG HFE NLRP1 CRTC2 SPIRE1 NFE2L2 TSC1 S100A8 CAMKK2 SLC2A4 RPS6 RAF1 FAM20C ULK1 SMC1A PCK2 CAMK1 CCNE1 HMBS HK2 TSPAN8 FIS1 SLC38A5 ABCA1 CYB5R3 CALM1 CHRM3 CAMK4 RPTOR MAP1LC3A RAC1 PENTOSE PHOSPHATE METABOLISM%WIKIPATHWAYS_20260610%WP134%HOMO SAPIENS Pentose phosphate metabolism HEL107 HEL-S-304 RPE RPIA MIRNA BIOGENESIS%WIKIPATHWAYS_20260610%WP2338%HOMO SAPIENS miRNA biogenesis DGCR8 DROSHA DICER1 TARBP2 RAN XPO5 AMINO ACID METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260610%WP5213%HOMO SAPIENS Amino acid metabolism in triple negative breast cancer cells PHGDH GLS PSAT1 SLC7A11 PSPH DOPAMINERGIC NEUROGENESIS%WIKIPATHWAYS_20260610%WP2855%HOMO SAPIENS Dopaminergic neurogenesis NKX6-1 MSX1 DDC CDKN1C SLC6A3 PITX3 SOX2 EN2 LMX1A TH OTX2 ASCL1 LMX1B HEL-S-53e GBX2 STAT3 NEUROD1 RET NEUROG2 NKX2-2 SHH FGF8 TGFB1 SLC18A2 EN1 WNT1 FOXA2 EFFECT OF DASATINIB ON THE BCR ABL SIGNALING PATHWAY%WIKIPATHWAYS_20260610%WP5493%HOMO SAPIENS Effect of dasatinib on the BCR ABL signaling pathway DOK1 PIK3CA RPS6KA1 SOS1 CRK CRKL INPP5D SPAG1 HSPB2 BCL9 SHC2 SHC3 BCR SHC1 PIK3R1 NRAS MAPK1 MAPK3 MEF2C ATF2 RAF1 ARAF PXN AKT3 MAPK14 BCLAF1 BCL2 GRB2 GAB2 VAV1 MAP3K2 CBL HEL-S-102 MAPK11 SRC HRAS EIF4B SHC4 WARBURG EFFECT MODULATED BY DEUBIQUITINATING ENZYMES AND THEIR SUBSTRATES%WIKIPATHWAYS_20260610%WP5216%HOMO SAPIENS Warburg effect modulated by deubiquitinating enzymes and their substrates MTOR PGAM1 PIK3CA SIRT7 HEL-S-133P HK2 U2AF2 HEL-S-68p FBP1 MYC OTUB2 USP37 USP44 USP28 USP19 VHL G6PC1 FOXO1 OTUD6B OTUD7B HIF1A VEGFA KDR P38 MAPK SIGNALING%WIKIPATHWAYS_20260610%WP400%HOMO SAPIENS p38 MAPK signaling MAP2K4 CDC42 MEF2D MAP3K5 MYC CREB1 RPS6KA5 MAPKAPK2 SHC1 RASGRF1 TGFBR1 TRADD ATF2 HMGN1 STAT1 MAPK14 TRAF2 GRB2 MAP3K7 HEL-S-102 DDIT3 MAPKAPK5 HRAS RIPK1 MAP2K6 MAP3K1 RAC1 SMIM40 MAX EDA SIGNALING IN HAIR FOLLICLE DEVELOPMENT%WIKIPATHWAYS_20260610%WP3930%HOMO SAPIENS EDA signaling in hair follicle development LTB BMP1 EDARADD RELB DKK1 WNT3 SHH DKK4 TNLG7C PTCH1 EDAR SOSTDC1 EBSTEIN BARR VIRUS LMP1 SIGNALING%WIKIPATHWAYS_20260610%WP262%HOMO SAPIENS Ebstein Barr virus LMP1 signaling IFNB1 IKBKG CHUK RELA CCL20 NFKBIA TRAF6 MAPK8 MAP3K7 MAPK1 NFKB1 CXCL8 NFKB2 TRADD MAP3K14 CCL5 PDLIM7 TRAF1 IRAK1 TNF IKBKB SYNAPTIC VESICLE PATHWAY%WIKIPATHWAYS_20260610%WP2267%HOMO SAPIENS Synaptic vesicle pathway STX2 STXBP1 AP2A1 AP2A2 SLC38A1 NAPA SYT1 SYP CPLX1 SYN1 SLC22A3 STX1B CPLX2 RIMS1 CLN8 SLC17A8 SLC18A1 DNM3 UNC13C SLC32A1 SYN2 SNAP25 STX3A CLTCL1 UNC13B UNC13A AP2M1 HEL-S-67p SLC18A3 VAMP2 STX1A CLTC SLC17A6 CLTA SLC17A7 AP2S1 CACNA1B CACNA1A SLC18A2 SLC1A3 SLC25A4 FELBAMATE METABOLISM%WIKIPATHWAYS_20260610%WP2816%HOMO SAPIENS Felbamate metabolism CYP2E1 CYP3A4 VITAMIN B6 DEPENDENT AND RESPONSIVE DISORDERS%WIKIPATHWAYS_20260610%WP4228%HOMO SAPIENS Vitamin B6 dependent and responsive disorders ALPI HEL-S-302 ALDH7A1 PIGV ALPL PLPBP HEL-S-1a GPR143 IN MELANOCYTES AND RETINAL PIGMENT EPITHELIUM CELLS%WIKIPATHWAYS_20260610%WP4941%HOMO SAPIENS GPR143 in melanocytes and retinal pigment epithelium cells PRKCB TYRP1 PRKACG TYR PLCB3 PLCB4 POMC DCT MC1R CREB1 PLCB1 PLCB2 GNAS GPR143 ADCY9 ASIP GNA15 DKFZp686L0365 VEGFA PMEL PEPTIDE GPCRS%WIKIPATHWAYS_20260610%WP24%HOMO SAPIENS Peptide GPCRs CCR3 OPRK1 HCRTR2 C3AR1 HCRTR1 CCR8 CCR7 CCR5 CCR4 CCR2 MC3R C5AR1 CXCR4 FPR1 NMBR LHCGR FPRL2 CCKBR TRHR MC2R GALR3 CCR6 GALR2 CXCR5 GALR1 CXCR6 CXCR1 NTSR2 MC1R TACR3 BRS3 CCKAR IL8RB EDNRA EDNRB AVPR1A CXCR3 OPRD1 OXTR FSHR MC5R GRPR NPY1R GNRHR GHSR MC4R ATP8A1 TACR2 CX3CR1 TAC4 NPY5R AVPR2 OPRM1 SSTR3 SSTR4 SSTR5 NTSR1 NPY4R AGTR1 AGTR2 FPR2 AVPR1B CCR10 TACR1 CCR1 SSTR2 BDKRB2 BDKRB1 TSHR NPY2R HALLMARK OF CANCER NON MUTATIONAL EPIGENETIC REPROGRAMMING%WIKIPATHWAYS_20260610%WP5483%HOMO SAPIENS Hallmark of cancer non mutational epigenetic reprogramming PIP4K2A ANKRD13C HDAC2 CADM1 TET2 EP300 NOL9 CREBBP IRS1 HDAC1 IFITM3 EZH2 SUZETRIGINE MECHANISM FOR PAIN RELIEF%WIKIPATHWAYS_20260610%WP5558%HOMO SAPIENS Suzetrigine mechanism for pain relief SCN10A KIT RECEPTOR SIGNALING%WIKIPATHWAYS_20260610%WP304%HOMO SAPIENS Kit receptor signaling PLCG1 PRKCB PTPN6 DOK1 PRKCA RPS6KA1 SOS1 CRK CRKL INPP5D MAP2K1 MAP2K2 SHC1 PIK3R2 MAPK8 PIK3R1 LYN MAPK1 GRB7 GRB10 SH2B2 MAPK3 FOXO3A RPS6 RAF1 BAD STAT1 STAT3 PTPN11 MAPK14 EP300 SOCS6 KIT BTK MATK TEC GRB2 GAB2 VAV1 STAT5B CBL SOCS1 SRC FYN HRAS KITLG RPS6KB1 OLIGODENDROCYTE DEVELOPMENT%WIKIPATHWAYS_20260610%WP5574%HOMO SAPIENS Oligodendrocyte development NKX6-1 SOX11 BMP1 NFIA HES5 NFATC2 PRKCA MYT1 MYRF SOX2 NKX2-6 SOX6 SOX5 OLIG2 SOX10 TMEM98 ASCL1 CSPG4 SOX8 WNT10A MBP ID4 CHD8 NKX2-2 PTN ZNF24 SHH DUSP15 RELN ZNF488 EGR2 ZBTB33 LGI1 ZEB2 OPALIN GIG8 CNTN1 TCF7L2 SOX9 PDGFRA SMAD1 BMP4 FGF2 OLIG1 MAPK AND NFKB SIGNALING INHIBITED BY YERSINIA YOPJ%WIKIPATHWAYS_20260610%WP3849%HOMO SAPIENS MAPK and NFkB signaling inhibited by Yersinia YopJ IKBKG CHUK MAPK1 NFKB1 MAP3K14 RAF1 MAP2K6 MAP3K1 IKBKB NFKBIA TRAF6 RRAS PHOTODYNAMIC THERAPY INDUCED AP 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260610%WP3611%HOMO SAPIENS Photodynamic therapy induced AP 1 survival signaling MAP2K4 HBEGF RB1 IL6 BMF CCND1 FGF7 MAP3K5 MMP2 MAPK8 NFE2L2 ATF2 EGFR CDKN2A TNF CCNE1 MAPK14 JUN BAX CCNA2 BCL2L11 TRAF2 MAP2K3 BCL2 IL2 TRAF6 TRAF5 BAK1 CDKN1A TNFSF10 JUNB PDGFRA MAPK12 MAPK13 MAPK11 TNFSF6 MAP2K6 IFNG BCL2L1 MCL1 FOS TNFRSF1A ARYLAMINE METABOLISM%WIKIPATHWAYS_20260610%WP694%HOMO SAPIENS Arylamine metabolism CYP1A2 UGT1A4 SULT1A1 UGT1A9 NAT2 SULT1A2 ALPHA 6 BETA 4 SIGNALING%WIKIPATHWAYS_20260610%WP244%HOMO SAPIENS Alpha 6 beta 4 signaling ITGA6 PRKCA SOS1 ARHA SHC1 PIK3R2 ITGB4 PIK3R1 LAMC2 MAPK1 LAMC1 MAPK3 EIF4EBP1 PTPN11 MAPK14 LAMA5 MTOR LAMA1 LAMA3 IRS1 LAMB3 GRB2 LAMB2 LAMB1 SRC HRAS RAC1 SPHINGOLIPID METABOLISM INTEGRATED PATHWAY%WIKIPATHWAYS_20260610%WP4726%HOMO SAPIENS Sphingolipid metabolism integrated pathway SPHK1 SGMS2 SGPP1 UGCG SMPD1 SGPP2 DEGS1 PLPP3 PLPP2 KDSR PLPP1 SPTLC2 CERS3 CERS5 SPTLC1 CERS2 CERS6 CERK SGMS1 LASS1 UGT8 DEGS2 SGPL1 SPHK2 FAMILIAL HYPERLIPIDEMIA TYPE 4%WIKIPATHWAYS_20260610%WP5111%HOMO SAPIENS Familial hyperlipidemia type 4 MTTP GCK LIPC ACSS1 LDLR PLTP SEL1L GPIHBP1 APOA2 LMF1 PDIA2 APOA4 APOA5 LPL APOC2 GCKR DGAT2 FOLATE METABOLISM%WIKIPATHWAYS_20260610%WP176%HOMO SAPIENS Folate metabolism PLAT CBS IL1B CSF1 FOLR1 GPX2 GPX1 MPO TNF GPX3 GPX6 CRP FLAD1 SCARB1 APOB LDLR RELA MAT1A IL2 SLC46A1 MTHFS DHFR MTHFD1 MTHFD2 SLC19A1 CCL2 SHMT1 CTH MTR HEL-S-51e IL6 SERPINA3 HEL-S-44 FGA F7 INSR NFKB1 SAA4 NFKB2 PLG HEL-S-78p ALB SAA1 SAA2 MTRR HBB HBA2 ABCA1 INS IL4 IZUMO1R FOLR3 FOLR2 GPX4 F2 IFNG CYCLIN DEPENDENT KINASE 4 6 INHIBITORS IN BREAST CANCER%WIKIPATHWAYS_20260610%WP5497%HOMO SAPIENS Cyclin dependent kinase 4 6 inhibitors in breast cancer PIK3CA PIK3R4 CCND1 ERBB2 PIK3R3 PIK3R2 PIK3R1 NRAS MAPK1 MAPK3 RAF1 EGFR AKT3 CCNE1 MTOR CDK4 IRS1 PIK3CD INS CDK2 CDK6 CDKN1A CDKN1B PIK3R5 RPTOR HRAS PIK3C2G IGF1R PIK3C2B IL7 SIGNALING%WIKIPATHWAYS_20260610%WP205%HOMO SAPIENS IL7 signaling IL7 IL7R MAP2K1 GSK3B MAP2K2 PIK3R2 STAT5B PIK3R1 MAPK1 PTK2B JAK3 MAPK3 FYN BAD STAT1 JAK1 STAT3 IL2RG LIPID METABOLISM IN SENESCENT CELLS%WIKIPATHWAYS_20260610%WP5149%HOMO SAPIENS Lipid metabolism in senescent cells PLA2G12B PLA2G5 PLA2G2D PLA2G6 PLA2G4F PLA2G4D PLA2G4E PLA2G4C CDKN1A PLA2G1B ALOX5 SLCO2A1 PLA2G7 PLA2G3 PLA2G10 HRAS PTGS2 PLA2G12A HUNGER AND SATIETY%WIKIPATHWAYS_20260610%WP5445%HOMO SAPIENS Hunger and satiety GHRL AgRP PYY GCG POMC LEP MC4R NPY JOUBERT SYNDROME%WIKIPATHWAYS_20260610%WP4656%HOMO SAPIENS Joubert syndrome ARL3 KAT5 SUFU CEP97 NPHP1 NPHP3 PIBF1 CPLANE1 FLNA TMEM231 TMEM17 AHI-1 ARHA TMEM237 UNC119 INVS TCTN3 TCTN2 TTC8 PDE6A TCTN1 PDE6G CC2D2A OFD1 DVL3 CEP164 MRE11A BBS2 NEK8 MTOR RAD50 BBS1 RP2 TMEM216 PCM1 MYO6 ARL13B TMEM67 MKS1 PDE6D CETN2 BBS9 B9D1 CEP41 BBS7 ZNF423 B9D2 CEP290 BBS5 BBS4 RAB8A ATF4 RHEB SHH ARMC9 ATM INPP5E CCP110 ARR3 ARL2 RPGRIP1L PCNT RAB3IP TMEM138 DVL1 CEP104 NEUROINFLAMMATION AND GLUTAMATERGIC SIGNALING%WIKIPATHWAYS_20260610%WP5083%HOMO SAPIENS Neuroinflammation and glutamatergic signaling CAMK2A TGFBR2 PLCB3 PLCB4 CREB1 PLCB1 PLCB2 CAMK2D TNF IL6ST IL6R IL10 IRS1 IL1R2 PIG59 TRAF5 GRIA2 SOCS3 SLC1A1 SLC1A2 SLC1A3 SMAD4 NGF GLS GRIA3 GRIA4 PSPH PDHA1 GRIN2B GRIN3B GRIN3A IL6 GRIK5 GRIK3 HEL-S-15 GRIK1 PSAT1 GRIK2 GRM2 IL13RA1 CAMKK1 TGFBR1 CAMKK2 GRM8 GLS2 SLC6A9 SMAD2 BCL2 IL4 CNTF CALM1 IL1R1 SLC17A6 SLC17A7 GRIN1 BDNF JAK1 IFNG LIF FOS TGFBR3 IL1B MAPK1 MAPK3 IFNGR1 IFNGR2 STAT1 STAT3 DISC1 ADCY3 ADCY1 ADCY8 PPP1CC HEL-S-80p IL10RB IL10RA FGF2 PRKCB SHMT1 PRKCA HEL-S-51e SLC7A10 ARC SLC38A1 IGF1 GFAP INSR NFKB1 NFKB2 LTA TNFRSF1B SLC2A3 CAMK2G SLC1A4 SLC38A5 PHGDH IL12B DLAT IL12A TGFB1 IL13 DLD CAMK4 NELF SLC38A3 DAO IL1A LRRC8C LRRC8D LRRC8E TNFRSF1A VASOPRESSIN REGULATED WATER REABSORPTION%WIKIPATHWAYS_20260610%WP5085%HOMO SAPIENS Vasopressin regulated water reabsorption DYNC2LI1 HEL-S-47e DYNC1LI2 DCTN6 DYNC1I1 DCTN5 DCTN1 DYNC1LI1 DCTN4 AQP4 CREB1 HEL-S-77 GNAS DYNC1H1 RAB11B RAB5B CREB3L3 RAB5C CREB3L4 CREB3L2 PRKACG DYNLL2 DNCL1 RAB11A AVPR2 ADCY3 ADCY6 CREB3 VAMP2 DYNC2H1 ARHGDIB RAB5A ADCY9 CREB5 AQP3 AQP2 AVP ARHGDIG STX4A ALZHEIMER 39 S DISEASE%WIKIPATHWAYS_20260610%WP5124%HOMO SAPIENS Alzheimer 39 s disease TUBA3E MAPK10 TUBA1C TUBB6 TUBA1B TUBA1A PLCB3 PSMD9 PLCB4 TUBB1 PSMD6 TUBB PSMD4 PSMD3 TUBB4B KIF5A PSMD1 PLCB1 TUBB4A PLCB2 TUBA4A TUBB2A SNCA PSMC1 TUBA2 TUBA8 ERN1 TNF PPP3CC TRAF2 VDAC3 ATP2A1 XBP1 DDIT3 CACNA1F APH1B FADD PPP3R2 IRS4 CACNA1S PPP3R1 PSENEN IL6 BACE1 APP MAP3K5 PSEN2 PSEN1 LPL NRBF2 ATG2B MME PSMA2 KNS2 PSMA8 PSMB6 PSMB2 PSMB3 HEL-S-276 RTN3 GPR83 KLC4 KLC3 ADAM17 KLC2 NAE1 BECN2 HEL-S-61 AMBRA1 ADRM1 ATF4 SLC25A31 EIF2AK2 INS EIF2S1 MAPK9 FRAT2 CALM1 CSNK2A3 CSNK2A2 DKK1 DKK2 DKK4 CSNK2B PSMD7 IL1B PSMD12 PSMD13 DVL3 CALML6 CALML3 CALML4 MCU CSNK1A1L PPP3CA CYBB GSK3B WNT2B FZD10 PIK3R3 PIK3R2 WNT5B PIK3R1 ITPR2 NRAS WNT16 RB1CC1 WNT3 WNT4 ULK1 WNT10B WNT10A PPIF FZD3 FZD5 CACNA1C WNT7B FZD9 WNT7A RTN4 FRAT1 SLC25A5 HEL-S-91n DVL1 ATP2A2 FZD2 AXIN2 CSNK1A1 CSF1 PSMC6 APC PSMC4 AGER IRS1 PIK3CD HEL-S-162eP WNT3A SHFM1 HSD17B10 PSMD2 GRIN2B CSNK2A1 PIK3R4 WIPI1 MAP2K1 ULK2 MAP2K2 FZD7 AXIN1 FZD8 SFRP4 RAF1 APAF1 DVL2 CDK5R1 CDK5 CYCS LRP5 GRIN1 CASP9 LRP6 CASP8 CASP3 HRAS FZD1 CASP12 PIK3CA ATG101 WIPI2 ATG14 MAPK8 MAPK1 ATG2A MAPK3 BAD ARAF RYR3 IKBKB AKT3 MTOR CHUK RELA SLC25A6 hCG_2014051 ADAM10 APOE APC2 INSR NFKB1 NOX4 CHRNA7 PSMA4 NOS2 IL1A PTGS2 TUBAL3 WNT1 TUBB8 TNFRSF1A SLC25A4 IL26 SIGNALING%WIKIPATHWAYS_20260610%WP5347%HOMO SAPIENS IL26 signaling CTSK NFATC1 PIK3CA IL6 IL26 DCSTAMP IL1B MAPK8 MAPK1 CSF2 EPHA3 CXCL8 MAPK3 STAT1 MPO TNF STAT3 MAPK14 SMAD2 JUN ACTA2 BAX COX2 IL10 IL33 RELA MAPK9 CCL20 TYK2 NFKBIA IL10RB DDIT3 IL17A IL20RA SOCS3 DEFB4B CASP3 JAK1 ATP6V0D2 MMP9 RORC TNFSF11 LEUCINE ISOLEUCINE AND VALINE METABOLISM%WIKIPATHWAYS_20260610%WP4686%HOMO SAPIENS Leucine isoleucine and valine metabolism ACAD8 MCCC2 ACSF3 IVD DBT MLYCD MCCC1 PCCA PCCB HSD17B10 DLD ACADSB BCAT2 ECHS1 ACAT1 BCAT1 TGIF DISRUPTION OF SHH SIGNALING%WIKIPATHWAYS_20260610%WP3674%HOMO SAPIENS Tgif disruption of Shh signaling SMAD2 FOXG1 TGIF2 GLI3 NODAL SHH NKX2-1 TGIF1 FGF8 BMP SIGNALING IN EYELID DEVELOPMENT%WIKIPATHWAYS_20260610%WP3927%HOMO SAPIENS BMP signaling in eyelid development FOXC1 PITX2 FGFR2 JUN NOTCH1 FGF10 FOXC2 SHH DKFZp781O1323 MAPK9 TGFA INHBB SMAD1 MAPK3 SMAD4 DKK2 BMP4 EGFR SFRP1 MAP3K1 ARACHIDONIC ACID AA ARA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260610%WP5155%HOMO SAPIENS Arachidonic acid AA ARA oxylipin metabolism EPHX2 PTGS2 PTGS1 GLP 1 SECRETION FROM INTESTINE TO PORTAL VEIN%WIKIPATHWAYS_20260610%WP5446%HOMO SAPIENS GLP 1 secretion from intestine to portal vein PCSK1 SLC2A2 GCG SLC5A1 MRNA PROTEIN AND METABOLITE INDUCED STRESS PATHWAY BY CYCLOSPORIN A%WIKIPATHWAYS_20260610%WP3953%HOMO SAPIENS mRNA protein and metabolite induced stress pathway by cyclosporin A SLC3A2 NFE2L2 ATF4 SLC7A5 KEAP1 SLC7A11 NANOPARTICLE TRIGGERED REGULATED NECROSIS%WIKIPATHWAYS_20260610%WP2513%HOMO SAPIENS Nanoparticle triggered regulated necrosis MAPK8 RIPK3 FTL TRADD CASP8 TICAM1 RIPK1 FADD TNF TNFRSF1A DEVELOPMENT AND HETEROGENEITY OF THE ILC FAMILY%WIKIPATHWAYS_20260610%WP3893%HOMO SAPIENS Development and heterogeneity of the ILC family GFI1 IL6 IL22 RORA HNF1A IL1B NFIL3 TBX21 IL23A TNF IL5 IL7 AREG TOX GATA3 IL25 AHR IL12B IL12A IL33 GIG8 IL4 IL13 ATL1-beta ZBTB16 IL17A IL9 IL18 TSLP IFNG RORC LACTATE SHUTTLE IN GLIAL CELLS%WIKIPATHWAYS_20260610%WP5314%HOMO SAPIENS Lactate shuttle in glial cells SLC2A3 HEL-S-133P HEL-76 NUDT14 SLC1A2 SLC4A4 SLC16A3 CA4 HEL-S-281 SLC16A7 MEASLES VIRUS INFECTION%WIKIPATHWAYS_20260610%WP4630%HOMO SAPIENS Measles virus infection MAPK10 LNIR RCHY1 RAB9B CD46 TRADD TBK1 IFNAR2 PIK3CD IRF3 IFIH1 TRAF3 IL2 TYK2 TRAF6 IRF7 TLR7 IFNAR1 IRF9 OAS2 JAK3 TNFAIP3 FADD BCL2L1 OAS3 IFNB1 HSPA2 STAT2 IKBKE MX1 HEL70 CSNK2A1 MAVS IL6 CCND1 RIGI CLEC4M BBC3 HEL-S-72p CCND3 CCND2 APAF1 EIF3S3 CCNE2 CCNE1 JUN HSPA1A IRAK4 CDK4 TLR9 EIF2AK2 CDK2 EIF2S1 BCL2 IFNA5 CDK6 IFNA4 MAPK9 NFKBIA IFNA7 CD209 IFNA6 CYCS IFNA1 IFNA2 IFNA8 OAS1 CDKN1B CSNK2A3 CSNK2A2 CASP9 CASP8 CASP3 IRAK1 JAK1 CSNK2B FOS MYD88 PIK3CA IFNA13 IFNA14 IFNA16 IFNA17 IL1B MAPK8 IFNA10 RAB9A IFNA21 BAD STAT1 STAT3 IKBKB IKBKG CHUK BAX RELA STAT5B EIF2AK1 EIF2AK4 CD3G CD3E PIK3R3 PIK3R2 NFKBIB PIK3R1 TLR4 NFKB1 NFKB2 IL2RG IL2RA IL2RB FCGR2B IL12B IL12A BAK1 TP73 MAP3K7 IL1A TNFSF6 CD3D ADAR SLEEP REGULATION%WIKIPATHWAYS_20260610%WP3591%HOMO SAPIENS Sleep regulation HEL-S-2 UTS2R SLC29A1 PTGDR HCRTR2 HTR2A HCRTR1 IL6 OXTR GHRH UTS2 MRGPRX2 BTBD9 CRH DRD2 CHRNB2 TH NPAS2 DRD1 NPS OXT STAR GHRL ADA DLAT DRD3 IL18 ADORA2A NLGN1 PER3 NPY2R CACNA1I FOS MTNR1B TGF BETA SIGNALING IN THYROID CELLS FOR EPITHELIAL MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260610%WP3859%HOMO SAPIENS TGF beta signaling in thyroid cells for epithelial mesenchymal transition SMAD2 TNC ID1 CDH2 CDH16 SNAI1 SNAI2 MAPK1 CDH6 MAPK3 SMAD4 RUNX2 HEL113 AKT3 SICKLE CELL DISEASE%WIKIPATHWAYS_20260610%WP5604%HOMO SAPIENS Sickle cell disease TLR4 IL18 HBB HBA2 IL1B INSULIN SIGNALING IN ADIPOCYTES NORMAL CONDITION %WIKIPATHWAYS_20260610%WP3634%HOMO SAPIENS Insulin signaling in adipocytes normal condition MTOR TBC1D4 INSR SLC2A4 IRS1 RPS6 RPS6KB1 ANK2 PATHWAY IN EPILEPSY DEVELOPMENT%WIKIPATHWAYS_20260610%WP5557%HOMO SAPIENS ANK2 pathway in epilepsy development PRRT2 ATF4 CSNK2A1 KCNQ2 SPTBN4 SCN2A BRSK1 ANK2 EIF2A SCN5A SPTAN1 DDIT3 CSNK2A2 SNAP25 SEMA3A L1CAM CSNK2B NEOLACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260610%WP5302%HOMO SAPIENS Neolacto series sphingolipid metabolism NAGA B4GALT1 hCG_1998026 B3GNT5 FUT1 B4GALT4 NEU2 FUCA1 SIAT4C FUT5 HIPPO SIGNALING REGULATION%WIKIPATHWAYS_20260610%WP4540%HOMO SAPIENS Hippo signaling regulation CDH17 PLCB3 PLCB4 TEAD2 PRKAR1B TEAD3 TEAD4 PRKAR1A CDC42 PLCB1 PLCB2 GNAS ARHA PRKAA1 CDH9 CDH8 CDH6 CDH4 FLT3 EGFR CDH24 PRKACG WWTR1 MTOR PRKD3 KIT FLT4 CSF1R LATS1 CDH2 CDH10 CDH12 LEF1 CDH15 CDH16 CDH19 GNAI3 TCF7L2 TCF7L1 PDGFRA FLT1 NTRK1 IGF1R KDR GNAL FGFR4 PRKCB PRKCI FGFR2 PRKCH PRKCA PRKCQ PRKCZ PRKAB2 PRKAB1 FGFR1 LATS2 INSR NTRK2 PRKAG1 PRKAG2 PRKAG3 FGFR3 SMAD2 PRKCE EPHA2 GNA11 PRKAA2 CDH18 NF2 YAP1 NGFR CDH11 RAC1 DISORDERS IN KETOLYSIS%WIKIPATHWAYS_20260610%WP5195%HOMO SAPIENS Disorders in ketolysis HMGCS1 BDH1 OXCT1 ACAT1 ACAT2 RELATIONSHIP BETWEEN INFLAMMATION COX 2 AND EGFR%WIKIPATHWAYS_20260610%WP4483%HOMO SAPIENS Relationship between inflammation COX 2 and EGFR PIK3CA PIK3CD PLA1A NRAS MAPK1 PTGER1 PTGER2 MAPK3 PTGER3 PTGER4 SRC EGFR HRAS PTGS2 AKT3 METASTATIC BRAIN TUMOR%WIKIPATHWAYS_20260610%WP2249%HOMO SAPIENS Metastatic brain tumor PIK3R1 E2F3 CDC42 MYC CDK6 LDLRAD4 INTRONIC SNP EFFECT ON COVID PATIENTS%WIKIPATHWAYS_20260610%WP4904%HOMO SAPIENS LDLRAD4 intronic SNP effect on COVID patients NEDD4 TMEPAI SMAD2 TGFBR2 TGFBR1 ATG16L1 WNT SIGNALING IN ADULT HIPPOCAMPAL NEUROGENESIS%WIKIPATHWAYS_20260610%WP5536%HOMO SAPIENS Wnt signaling in adult hippocampal neurogenesis NEUROD1 PROX1 WNT7A NEUROG2 LRP6 CCND1 WNT3 FZD1 FZD3 WNT3A CELLS AND MOLECULES INVOLVED IN LOCAL ACUTE INFLAMMATORY RESPONSE %WIKIPATHWAYS_20260610%WP4493%HOMO SAPIENS Cells and molecules involved in local acute inflammatory response IL6 ITGB1 SELPLG VCAM1 ITGA4 C6 HEL-S-62p C7 SELP CXCL8 KNG1 IL1A TNF ENERGY METABOLISM%WIKIPATHWAYS_20260610%WP1541%HOMO SAPIENS Energy metabolism PPP3R2 MYBBP1A MEF2B PPP3R1 PPP3CA UCP3 MEF2D NCOA1 UCP2 CREB1 PRKAB2 SIRT3 GSK3B PRKAB1 PRKAA1 RXRA FOXO1 PPARGC1A MEF2C ATF2 FOXO3A PPARG PRKAG1 NR1C2 PRKAG2 PRKAG3 PPP3CC MAPK14 CAMK2G EP300 PRKAA2 ESRRA PRMT1 TFB2M NRF1 TFB1M MED1 PPRC1 CAMK4 TFAM PPARGC1B GABPA NR1C1 SIRT1 HDAC1 LUNG FIBROSIS%WIKIPATHWAYS_20260610%WP3624%HOMO SAPIENS Lung fibrosis CSF3 CCR3 HMOX1 ATP11A FGF7 IL1B FAM13A SFTPC RTEL1 DPP9 CSF2 CCR2 STN1 CXCL8 MUC5B SKIL PTX3 SFTPA1 CXCL2 TNF CCL11 ELMOD2 TERT CTGF SERPINA1 CCL5 EDN1 CCL4 FGF2 CCL3 CCL2 MMP9 IL6 EGF MMP2 CMA1 TGFA IGF1 KPG_011 HGF NFE2L2 CEBPB opn SFTPA2 CALCA IL5 PDGFA IL12B IL4 IL13 GREM1 TGFB1 BMP7 TIMP1 PILOCYTIC ASTROCYTOMA%WIKIPATHWAYS_20260610%WP2253%HOMO SAPIENS Pilocytic astrocytoma PTPN11 NRAS SOS1 RAF1 HRAS NF1 GRB2 INSULIN SIGNALING%WIKIPATHWAYS_20260610%WP481%HOMO SAPIENS Insulin signaling MAPK10 PFKM EGR1 RPS6KA5 PRKAA1 KIF3A STXBP3 STXBP4 RRAD EHD1 EHD2 SNX26 PPP1R3A ARF6 IRS1 PIK3CD RPS6KA4 MAP2K3 XBP1 RAB4A CBL SOCS3 SOCS1 TRIB3 EIF4E MAP2K6 MAP3K1 RPS6KB1 IRS4 MYO1C CBLC RPS6KA6 RPS6KA2 RPS6KA1 PIK3R4 MAP3K8 MAP3K6 MAP3K5 PFKL MAP2K1 MAP2K2 SHC2 SHC3 SHC1 TSC2 TSC1 GRB14 MAP3K10 MAP3K13 MAP3K14 SH2B2 MAP3K11 RAF1 MAP3K12 GSK3A SNAP25 HEL-S-31 EIF4EBP1 FLOT1 FLOT2 HEL-S-61 CAP1 JUN SNAP23 MAP4K2 MINK1 RHEB PRKAA2 MAPK9 GRB2 MAPK7 VAMP2 MAPK6 MAPK4 MAP4K3 MAP3K2 INPP4A GYS2 PTPN1 PTEN HEL-S-42 ARF1 SGK1 MAPK12 SGK2 MAPK13 MAPK11 GYS1 HRAS MAP4K1 RAC1 FOS STXBP1 PIK3CA RAPGEF1 SOS1 CRK MAPK8 MAPK1 PTPRF MAPK3 IKBKB PTPN11 MAPK14 MTOR LIPE SOS2 INPPL1 RPS6KB2 PIK3C2G IGF1R MAP2K4 PRKCB PRKCI PRKCH PDPK1 PRKCA PRKCQ PRKCZ MAP2K5 GSK3B PIK3R3 PIK3R2 PIK3R1 FOXO1 INSR GRB10 SLC2A4 FOXO3A GYG1 ENPP1 TBC1D4 MAP3K7 STX4A DISORDERS OF BILE ACID SYNTHESIS AND BILIARY TRANSPORT%WIKIPATHWAYS_20260610%WP5176%HOMO SAPIENS Disorders of bile acid synthesis and biliary transport SLC10A2 SLC27A2 CYP7B1 AMACR ABCC3 ATP8B1 AKR1C4 ABCB4 HSD3B7 ABCC2 BAAT CYP7A1 ABCB1 CYP8B1 HSD17B4 ABCB11 SLC27A5 ABCD3 CYP27A1 SLCO1B1 SLC51A AKR1D1 SLC51B FABP6 GLYCOSPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260610%WP5292%HOMO SAPIENS Glycosphingolipid metabolism B3GALT2 UGCG B3GALT1 NEU4 GLA GBA2 UGT8 B3GNT5 B4GALNT1 A4GALT A3GALT2 B4GALT4 NEU3 ST3GAL5 B4GALT5 CANONICAL NF KB PATHWAY%WIKIPATHWAYS_20260610%WP4562%HOMO SAPIENS Canonical NF kB pathway REL IKBKG CHUK NFKB1 RELA IKBKB NFKBIA NFKBIE ESTROGEN METABOLISM%WIKIPATHWAYS_20260610%WP697%HOMO SAPIENS Estrogen metabolism CYP1A2 UGT1A3 UGT1A1 NQO1 CYP1A1 UGT2B7 CYP1B1 UGT1A9 CYP3A4 STS SULT1A1 SULT1E1 GSTM1 ARSL UREA CYCLE AND RELATED DISEASES%WIKIPATHWAYS_20260610%WP4571%HOMO SAPIENS Urea cycle and related diseases SLC25A15 OTC ASL NAGS SLC25A13 ASS1 ARG1 GLS2 16P13 11 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260610%WP5502%HOMO SAPIENS 16p13 11 copy number variation syndrome DCTN6 DCTN1 DCTN4 PLAGL1 CEP170 OFD1 PLAG1 RAP1A ACTR1B BMERB1 NDE1 ABCC6 MARF1 GATA3 PLK1 DCP1A DISC1 ACTR10 DCP2 RAPGEF4 PCM1 CEP20 PAFAH1B1 ABCC1 KIAA0753 MICROTUBULE CYTOSKELETON REGULATION%WIKIPATHWAYS_20260610%WP2038%HOMO SAPIENS Microtubule cytoskeleton regulation PRKCA CDC42 SPRED1 MAP1B MAPKAPK2 GSK3B RHO PAK1 CFL2 PARD6A APC MARK1 NTRK2 NTRK3 STAT3 AURKB PHLDB2 TIAM1 TAOK1 ROCK1 CDC2 MAPRE1 WNT3A TRIO FREP1 PTEN EPHB2 CAMK4 NTRK1 LIMK1 SRC CLASP1 F2RL2 DVL1 RAC1 NOTCH SIGNALING%WIKIPATHWAYS_20260610%WP268%HOMO SAPIENS Notch signaling KAT2B NOTCH4 RBPJ HES5 JAG2 NOTCH1 MAML3 DLL3 DLL4 PSEN2 PSEN1 KCNJ5 HES1 CTBP2 NCOR2 DVL2 DVL3 ADAM17 NOTCH2 DTX4 DTX2 DTX3 LFNG DTX3L MFNG CTBP1 KAT2A MAML1 HDAC2 NUMB CREBBP HDAC1 DTX1 DVL1 APH1B RBPJL NOTCH3 SOX GENES AND THEIR INFLUENCE ON NEUROGENESIS AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260610%WP5568%HOMO SAPIENS SOX genes and their influence on neurogenesis and neurodevelopmental disorders SOX11 WWTR1 YES1 TEAD2 FGF4 SRRT SOX2 SOX12 POU3F1 UTF1 SOX15 H4C9 ZSCAN10 SOX4 POU3F2 HIST1H4L HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20260610%WP186%HOMO SAPIENS Homologous recombination RAD54B RAD50 POLD2 RPA1 NBN RAD52 BRCA2 POLD3 POLD4 RAD51 MRE11A ATM BIOSYNTHESIS AND TURNOVER OF 1 DEOXY SPHINGOID BASES%WIKIPATHWAYS_20260610%WP5179%HOMO SAPIENS Biosynthesis and turnover of 1 deoxy sphingoid bases SPHK1 SGPP1 SGPP2 KDSR SPTLC2 SPTLC1 SPHK2 GLYCEROL METABOLISM INCLUDING LINKED IMDS%WIKIPATHWAYS_20260610%WP5570%HOMO SAPIENS Glycerol metabolism including linked IMDs HEL-S-87p MGLL HEL-S-165mP PGAM1 PC KHK LIPE GPD1 HEL-S-68p FBP1 PNPLA2 PFKL HEL-S-162eP ALDOB AGXT PCK1 GLYCTK G6PC1 AQP7 GPD2 ENO1 PKLR AQP9 HEL-S-49 NAD BIOSYNTHESIS II FROM TRYPTOPHAN%WIKIPATHWAYS_20260610%WP2485%HOMO SAPIENS NAD biosynthesis II from tryptophan KYNU KMO NMNAT1 HAAO TDO2 AFMID NADSYN1 HEL-S-90n AIRWAY SMOOTH MUSCLE CELL CONTRACTION%WIKIPATHWAYS_20260610%WP4962%HOMO SAPIENS Airway smooth muscle cell contraction GDI1 ROCK1 ROCK2 MYL1 ADRB2 MYLK PLCB1 IL13 ARHA CALM1 HEL-S-80p PPP1R14A RYR1 CARDIOMYOCYTE SIGNALING CONVERGING ON TITIN%WIKIPATHWAYS_20260610%WP5344%HOMO SAPIENS Cardiomyocyte signaling converging on titin GUCY1B1 CAMK2A PRKCA FHL2 PRKAR1A MAP2K1 MAP2K2 ANKRD2 MAPK1 TTN ANKRD1 RAF1 MYPN PRKACG NUP62 TRIM63 ANKRD23 ADRB1 TCAP ADRB2 NBR1 MDM2 CSRP3 HEL-S-101 C22orf13 TRIM55 FHL1 H19 RB E2F1 AND CDK BETA CATENIN IN COLORECTAL CANCER%WIKIPATHWAYS_20260610%WP3969%HOMO SAPIENS H19 Rb E2F1 and CDK beta catenin in colorectal cancer CDK8 SOX4 MED1 PMAIP1 RB1 CCND1 CDK4 CSRP2 PSORIASIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260610%WP5537%HOMO SAPIENS Psoriasis mechanism and therapies IL12RB1 IL22 IL12B CCL20 TYK2 IL1B IL23R IL17F IL17A CXCL8 HLA-C CXCL1 IL17RC IL23A STAT3 TNF CCR6 SOMITOGENESIS IN THE CONTEXT OF SPONDYLOCOSTAL DYSOSTOSIS%WIKIPATHWAYS_20260610%WP4785%HOMO SAPIENS Somitogenesis in the context of spondylocostal dysostosis NOTCH1 MESP2 HES7 DLL3 LFNG EPHA4 RIPPLY2 TBX6 HIPPO MERLIN SIGNALING DYSREGULATION%WIKIPATHWAYS_20260610%WP4541%HOMO SAPIENS Hippo Merlin signaling dysregulation CDH17 ITGA6 ITGAX ITGA1 PLCB4 TEAD2 PRKAR1B TEAD3 TEAD4 PRKAR1A CD44 VGLL4 ITGB1 CTNNA1 ITGA4 ITGA2 PAK1 ITGB7 CDH9 CDH8 CDH6 CDH4 ITGAM FLT3 EGFR CDH24 PRKACG WWTR1 LIN28B ITGA2B KIT FLT4 CSF1R LATS1 CDH2 CDH10 CDH12 CDH15 PPP1CC CDH16 CTGF CDH19 HEL-S-80p PDGFRA AJUBA PPP1R14A FLT1 NTRK1 DCAF1 IGF1R KDR FGFR4 FGFR2 RBX1 CCND1 CUL4A DDB1 MYC FGFR1 ITGB4 LATS2 NRAS INSR ITGB8 ITGB6 ITGAE NTRK2 ITGA7 FGFR3 EPHA2 PAK6 PAK4 CDH18 FOXM1 NF2 YAP1 ITGB3 NGFR ITGAV HRAS CDH11 AMOT FIBROTIC RESPONSE OF TRABECULAR MESHWORK CELLS TO TGFB3 AND ENPP2 IN AQUEOUS HUMOR%WIKIPATHWAYS_20260610%WP5545%HOMO SAPIENS Fibrotic response of trabecular meshwork cells to TGFB3 and ENPP2 in aqueous humor MAPK10 MAPK8 ACTA2 LPA ENPP2 COL1A1 MAPK9 STAT3 RHO TGFB1 CTGF BIOTIN METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260610%WP5031%HOMO SAPIENS Biotin metabolism including IMDs PCCB ACACB MCCC2 BTD ACACA PC MCCC1 HLCS PCCA GENES CONTROLLING NEPHROGENESIS%WIKIPATHWAYS_20260610%WP4823%HOMO SAPIENS Genes controlling nephrogenesis ETV4 FGFR2 LHX1 TCF2 CXCL12 HEL-S-28 ITGB1 ROBO2 NCK2 NCK1 EMX2 CXCR4 CD2AP NPHS1 LMX1B NPHS2 WNT4 WT1 CD36 RET FOXC1 NOTCH2 SIX1 HOXD11 SLIT2 GLI3 HOXA11 FOXC2 SHH FGF8 LAMB2 EYA1 FOXD1 TCF21 PAX2 MAFB VEGFA GDNF KDR CELL DIFFERENTIATION INDEX%WIKIPATHWAYS_20260610%WP2029%HOMO SAPIENS Cell differentiation index HDAC5 TLX2 LEFTY1 TLX1 TLX3 STAT3 LEFTY2 TCA CYCLE NUTRIENT USE AND INVASIVENESS OF OVARIAN CANCER%WIKIPATHWAYS_20260610%WP2868%HOMO SAPIENS TCA cycle nutrient use and invasiveness of ovarian cancer MAPK1 MAPK3 EGFR JAK1 STAT3 EXTRAFOLLICULAR AND FOLLICULAR B CELL ACTIVATION BY SARS COV 2%WIKIPATHWAYS_20260610%WP5218%HOMO SAPIENS Extrafollicular and follicular B cell activation by SARS CoV 2 PAX5 ITGAX MFGE8 IRF4 CR1 MAF SELL BCR IRF8 CCR7 IFITM1 CXCR4 CD79A TBX21 CXCL13 CD82 TNF IFIT2 CRP CXCR5 TNFSF13 TNLG7A CCL19 IL10 IFNAR2 IL2 XBP1 TLR7 CCL21 CR2 PDCD1 HEL-S-62p MS4A1 BCL6 ICOS BACH2 AID FCRL5 ISG15 CD1D SLAMF7 PTPRC IL-21 TMSB10 EBI3 IL6 CXCL12 SH2D1A C4A HEL-S-72p CD22 TLR4 FOXO1 CD69 BTLA CD40 CD80 CD40LG CD19 BASH IL12A ZEB2 GPR183 IL4 SYK IFNG GENES AND COMPLEXES INVOLVED IN THE DNA REPAIR PATHWAYS%WIKIPATHWAYS_20260610%WP4946%HOMO SAPIENS Genes and complexes involved in the DNA repair pathways SMUG1 CDK7 POLE TDG POLM POLL NHEJ1 FEN1 POLD3 POLD4 MRE11A FAAP24 FANCM POLD2 CENPX RAD50 FANCL REV1 CUL4B FANCB HMGB1 XPA FANCE FANCF RAD51C BRIP1 FAN1 WRN CENPS MPG OGG1 PNKP XRCC5 UNG RAD54B POLE4 NTHL1 USP1 FANCA MUTYH PALB2 MBD4 MSH3 NEIL3 TERF2 POLE2 BRCA2 POLE3 CCNH CETN2 REV3L XPC POLI GTF2H2C_2 LIG1 APEX2 RFC2 GTF2H2 GTF2H3 GTF2H4 GTF2H5 RFC3 RBX1 RFC4 CUL4A DDB1 ERCC1 CHEK1 ERCC2 ERCC5 MNAT1 H2AX PCNA MSH6 NEIL2 MSH2 NBN RPA1 FANCG WDR48 RFC1 RPA3 DDB2 PRKDC FANCD2 RAP1A POLK APEX1 RAD52 PMS2 RAD51 ATM ATR BRCA1 PARP2 GLUTATHIONE METABOLISM%WIKIPATHWAYS_20260610%WP100%HOMO SAPIENS Glutathione metabolism GSTT2 HEL-S-26 GCLM GCLC OPLAH GSTM2 GSTA5 HEL-S-64p GPX4 HEL-75 GPX2 GSTM1 GPX1 GPX3 AMINO ACID TRANSPORT DEFECTS IEMS %WIKIPATHWAYS_20260610%WP5029%HOMO SAPIENS Amino acid transport defects IEMs SLC3A2 SLC36A2 SLC1A1 SLC3A1 SLC6A19 SLC7A9 SLC7A7 SLC6A20 CLTRN MALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260610%WP5320%HOMO SAPIENS Male steroid hormones in cardiomyocyte energy metabolism HSD17B2 UGT1A1 SULT1A1 SRD5A2 HSD3B2 HSD17B3 HSD3B1 CYP17A1 CYP11A1 STING PATHWAY IN KAWASAKI LIKE DISEASE AND COVID 19%WIKIPATHWAYS_20260610%WP4961%HOMO SAPIENS STING pathway in Kawasaki like disease and COVID 19 IFNB1 TBK1 REL IKBKG CHUK IKBKE GSDMD FCGR2A F3 IRF3 RELA NFKBIA IL1B NFKBIE CGAS MITA NFKB1 NLRX1 IKBKB NLRP3 RALA DOWNSTREAM REGULATED GENES%WIKIPATHWAYS_20260610%WP2290%HOMO SAPIENS RalA downstream regulated genes EXOC2 RALA NRAS YBX3 CDC42 RAC3 RALBP1 EXOC8 HRAS RAC1 DISORDERS OF FRUCTOSE METABOLISM%WIKIPATHWAYS_20260610%WP5178%HOMO SAPIENS Disorders of fructose metabolism SORD SLC2A2 GLYCTK G6PC1 KHK FBP1 HEL-S-53e SLC5A1 PFKL ALDOB HEL-S-49 COPPER METABOLISM%WIKIPATHWAYS_20260610%WP5189%HOMO SAPIENS Copper metabolism ATP7A SLC31A1 SLC11A2 ATP7B CHOLESTEROL BIOSYNTHESIS PATHWAY IN HEPATOCYTES%WIKIPATHWAYS_20260610%WP5329%HOMO SAPIENS Cholesterol biosynthesis pathway in hepatocytes ELOVL4 PLPP6 CYP46A1 GGPS1 IDI2 FADS2 FDPS ABCG1 MVK HSD17B7 TM7SF2 PMVK DHCR24 ACAT2 MYLIP CYP27A1 HMGCS1 ELOVL5 NR1H2 ACSL1 ACSL3 CYP51A1 SCD HMGCR EBP CYP7A1 ABCA1 FDFT1 CH25H LBR SC5D MSMO1 NR1H3 ELOVL2 ELOVL3 MVD GANGLIO SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260610%WP1423%HOMO SAPIENS Ganglio sphingolipid metabolism B4GALNT1 SLC33A1 B3GALT1 FUT1 A3GALT2 ST6GALNAC6 ST8SIA1 B3GALT4 ST8SIA5 ST3GAL5 ST3GAL1 INTERACTIONS OF NATURAL KILLER CELLS IN PANCREATIC CANCER%WIKIPATHWAYS_20260610%WP5092%HOMO SAPIENS Interactions of natural killer cells in pancreatic cancer CD226 BMI1 KLRK1 NCR3LG1 TIGIT NCR1 MICB CD96 NCR3 MYC PRF1 MICA FCGR3A FOXO1 CSF2 TNF GATA2 ADAM17 CCL1 ADAM10 CCL5 CCL4 CCL3 CCL2 IFNG HLA C ALLOTYPES INTERACTIONS WITH KIR ON DNK CELLS%WIKIPATHWAYS_20260610%WP5580%HOMO SAPIENS HLA C allotypes interactions with KIR on dNK cells TYROBP PLCG1 PTPN6 LCP2 PRKCA PRKCQ NLRP7 NLRP2 ELF3 LAT VAV1 SYK CSF2 HLA-C FYN IFNG TNF KIR2DL1 RAC1 KIR2DL3 CYTOSOLIC DNA SENSING PATHWAY%WIKIPATHWAYS_20260610%WP4655%HOMO SAPIENS Cytosolic DNA sensing pathway IFNA13 IFNA14 IFNA16 IFNA17 IL1B POLR1C IFNA10 POLR1D TRADD IFNA21 IKBKB TBK1 IKBKG TRIM25 CHUK POLR2H POLR2K POLR2L POLR2F IRF3 IL33 RELA IRF7 POLR3GL POLR3A CCL5 POLR3B CCL4 POLR3C POLR3D RIPK1 ISG15 CCL4L2 FADD POLR3E POLR3F POLR3G IFNB1 POLR3H POLR3K IKBKE MAVS IL6 ATG12 DKFZp686F0183 ZBP1 RIGI RNF125 PYCARD NFKBIB RIPK3 AIM2 NFKB1 CYLD NLRX1 IFNA5 IFNA4 IFNA7 TREX1 NFKBIA IFNA6 IFNA1 CGAS CASP10 IFNA2 MITA IFNA8 IL18 CASP8 ADAR INFLUENCE OF LAMINOPATHIES ON WNT SIGNALING%WIKIPATHWAYS_20260610%WP4844%HOMO SAPIENS Influence of laminopathies on Wnt signaling HES5 CCND1 TOR1AIP1 CSNK1A1 GSK3B HES1 CEBPB CEBPD opn AXIN1 SLC2A4 PPARG WNT10B APC DICER1 CEBPA HMGA2 LEF1 ZMPSTE24 CDK6 EMD LMNA TCF7L2 TCF7L1 CSNK1A1L TARBP2 AGO2 RUNX2 FNTA ICMT JAK STAT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260610%WP5528%HOMO SAPIENS JAK STAT signaling and ARTD family members SKP1 HDAC3 HDAC2 BTRC RBX1 DTX3L STAT1 PARP11 STAT3 PARP14 ONE CARBON METABOLISM%WIKIPATHWAYS_20260610%WP241%HOMO SAPIENS One carbon metabolism SHMT1 MTR HEL-S-51e MTRR TCN2 HEL-S-61p MTFMT MAT1A CHDH AMT GLRX MTHFS FTCD DHFR FOLH1 MTHFD1 AHCYL2 MTHFD2 TYMS DNMT3B HEL-S-70p MTHFD1L NOVEL INTRACELLULAR COMPONENTS OF RIG I LIKE RECEPTOR PATHWAY%WIKIPATHWAYS_20260610%WP3865%HOMO SAPIENS Novel intracellular components of RIG I like receptor pathway MAPK10 MAPK8 CXCL8 TRADD TNF IKBKB TBK1 MAPK14 DHX58 IKBKG TRIM25 CHUK TRAF2 IRF3 DDX3X IFIH1 TRAF3 RELA TRAF6 IRF7 TANK RIPK1 ISG15 FADD MAP3K1 IFNB1 IKBKE MAVS SNW1 ATG12 CXCL12 DKFZp686F0183 RIGI RNF125 DDX3Y AZI2 NFKBIB OTUD5 SIKE1 PIN1 NFKB1 CYLD TBKBP1 IFNK NLRX1 MAPK9 NFKBIA IFNA1 CASP10 MITA MAP3K7 MAPK12 MAPK13 CASP8 MAPK11 IFNE IFNG GLYOXYLATE METABOLISM%WIKIPATHWAYS_20260610%WP5166%HOMO SAPIENS Glyoxylate metabolism AGXT SLC26A1 GOT2 PXMP2 HEL-S-133P HAO1 HOGA1 PRODH2 DAO PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20260610%WP98%HOMO SAPIENS Prostaglandin synthesis and regulation AKR1B1 TBXA2R PTGDR PTGIR AKR1C1 ANXA2 AKR1C2 ANXA6 S100A6 PTGER1 PPARGC1A PTGER2 PTGER3 PTGFRN PPARG ANXA3 ANXA4 S100A10 ANXA1 SCGB1A1 PTGIS CYP11A1 HEL-S-7 PTGES SOX9 HSD11B1 HSD11B2 PRL EDNRA PPARGC1B PTGER4 EDNRB EDN1 PTGFR PTGS2 HPGD PTGS1 PHOTODYNAMIC THERAPY INDUCED NFE2L2 NRF2 SURVIVAL SIGNALING%WIKIPATHWAYS_20260610%WP3612%HOMO SAPIENS Photodynamic therapy induced NFE2L2 NRF2 survival signaling HEL-S-22 MAPK14 SRXN1 ABCC6 JUN EPHX1 HMOX1 NQO1 GCLM KEAP1 ABCC3 GCLC ABCC2 MAPK8 NFE2L2 MAPK12 MAPK13 MAPK11 NQO2 FOS ABCG2 CES1 T CELL MODULATION AND DESMOPLASIA IN PANCREATIC CANCER%WIKIPATHWAYS_20260610%WP5078%HOMO SAPIENS T cell modulation and desmoplasia in pancreatic cancer PDGFD PDGFC CD226 TNFRSF4 ENTPD1 NR1i1 PDCD1LG2 TNLG5A IL6 TIGIT TNLG2B CXCL12 TNFRSF9 VEGFB VEGFC CXCR4 CD40 CD80 HLA-A CTLA4 VTCN1 VSIR B2M CD40LG FAP PDGFA HAVCR2 IL10 SHH LGALS9 ARG1 IL4 TGFB1 IL13 CCL22 NT5E CCL17 VEGFD PDCD1 ICOS TNFSF6 VEGFA IDO1 ALSTROM SYNDROME%WIKIPATHWAYS_20260610%WP5202%HOMO SAPIENS Alstrom syndrome IFT74 ALMS1 IFT81 TFDP2 DNM3 CEP192 PTCH1 BLOC1S4 VCPIP1 ACTN4 BLOC1S6 BLOC1S1 CIMAP3 SNAPIN RFX2 DTNBP1 CEP19 RFX3 RFX1 TUBG1 RILPL1 MYO5B VCP STX5A RABL2B E2F4 GPR161 IFT27 IFT172 IFT25 SMO ASPIRIN PREVENTION OF CANCER METASTASIS%WIKIPATHWAYS_20260610%WP5518%HOMO SAPIENS Aspirin prevention of cancer metastasis GNA13 TBXA2R ARHGEF1 PTGS1 ARHA FLAVAN 3 OL METABOLIC PATHWAY%WIKIPATHWAYS_20260610%WP4238%HOMO SAPIENS Flavan 3 ol metabolic pathway HORMONAL CONTROL OF PUBERTAL GROWTH SPURT%WIKIPATHWAYS_20260610%WP4194%HOMO SAPIENS Hormonal control of pubertal growth spurt IGF1 GNRH1 SST GHRH GH1 KENNEDY PATHWAY FROM SPHINGOLIPIDS%WIKIPATHWAYS_20260610%WP3933%HOMO SAPIENS Kennedy pathway from sphingolipids PTDSS1 PEMT CEPT1 CHKB PTDSS2 PCYT1B PCYT2 PISD SGPL1 CHKA CHPT1 OXIDATIVE DAMAGE RESPONSE%WIKIPATHWAYS_20260610%WP3941%HOMO SAPIENS Oxidative damage response MAP2K4 MAPK10 C3AR1 CDC42 TNK2 CDKN1C PCNA NFKBIE C1QA C5AR1 NFKB1 APAF1 BAD TRAF1 TNF TNFRSF1B C4B_2 C1QB GADD45A TRAF2 BCL2 TRAF3 TRAF6 C1S BAG4 BAK1 CYCS CDKN1A CDKN1B CR2 CASP9 MAPK13 CASP3 C1QC MAP3K1 SCFA AND SKELETAL MUSCLE SUBSTRATE METABOLISM%WIKIPATHWAYS_20260610%WP4030%HOMO SAPIENS SCFA and skeletal muscle substrate metabolism PYY GCG FFAR3 FFAR2 SLC2A4 NR1C2 MAPK SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260610%WP5530%HOMO SAPIENS MAPK signaling and ARTD family members MAP2K4 MAPK10 MAP3K8 MAP3K5 MAP2K1 MAP2K2 MAPK8 TNKS MAPK1 MAP3K10 MAPK3 MAP3K11 RAF1 MAP3K12 ARAF MAPK14 ATF4 MAP2K3 MAPK9 MAP3K21 MAP3K7 MAPK12 MAPK13 MAPK11 MAP2K6 MAP3K1 PARP14 PROTEASOME DEGRADATION%WIKIPATHWAYS_20260610%WP183%HOMO SAPIENS Proteasome degradation UBB PSMD7 UBC UBE2B PSMD9 PSMD6 PSMB8 PSMD4 PSMD5 PSMD3 RPN2 PSMD1 RPN1 PSMD10 H2AX PSMB9 HEL-117 PSMD11 PSMC1 NEDD4 PSMD12 PSMD13 H2AZ1 PSMA2 PSMC6 PSMB6 HLA-B PSMB2 HLA-C UBE2D1 PSMB3 HEL-S-276 HLA-A HLA-F UBE2D3 HLA-G PSMC4 HLA-E HIST1H2AB PSMA4 UBA7 PSMB10 HEL-S-283 PSME2 HEL-S-91n IFNG UBE2D2 PSMD2 TYPE II DIABETES MELLITUS%WIKIPATHWAYS_20260610%WP1584%HOMO SAPIENS Type II diabetes mellitus SLC2A2 MTOR INS-IGF2 PRKCZ IRS1 PDX1 MAPK8 SURF1 PIK3R5 MAPK1 INSR SOCS4 SLC2A4 CACNA1A PHKA2 TNF MAFA IKBKB METABOLIC PATHWAYS OF FIBROBLASTS%WIKIPATHWAYS_20260610%WP5312%HOMO SAPIENS Metabolic pathways of fibroblasts PLCG1 BMP1 P4HA1 HEL-S-133P GCK LPAR1 ALDH18A1 GLUD1 PHGDH PSAT1 FGFR1 LOXL2 ARHA P4HA2 P3H4 PLOD1 P3H3 ADAMTS2 P4HA3 GLS UGDH CD36 PSPH FGFR4 FAMILIAL HYPERLIPIDEMIA TYPE 2%WIKIPATHWAYS_20260610%WP5109%HOMO SAPIENS Familial hyperlipidemia type 2 EPHX2 LPL LIPC APOB USF1 GHR LDLR PLTP GPIHBP1 APOA2 PCSK9 APOA4 ENDOTHELIN PATHWAYS%WIKIPATHWAYS_20260610%WP2197%HOMO SAPIENS Endothelin pathways PTGIR GNB5 PRKCA ADRA1A CAD MYL1 PLCB1 MAP2K1 GNAS NPY1R HEL-S-14 MAPK1 RAF1 NPY CALCA GNAI1 CALCRL COX2 ADRB1 MYLK CALM1 HEL-S-7a ECE1 GNA15 RAMP1 EDNRA EDNRB EDN1 RIIAD1 ATP2A2 GNG13 PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS %WIKIPATHWAYS_20260610%WP2572%HOMO SAPIENS Primary focal segmental glomerulosclerosis FSGS NOTCH1 CR1 CDKN1C HEL-S-28 ITGB1 YWHAQ COL4A3 COL4A5 WT1 SMARCAL1 CD151 MYO1E HEL114 CDH2 IRF6 COL4A4 PLAUR FYN FAT1 TLN1 VTN PLCG1 AGRN PARVA PCNA PTPRO ITGB4 SYNPO NCK1 TLR4 MME CD2AP INF2 LMX1B NPHS1 NPHS2 CD80 DAG1 PLCE1 LAMA5 ACTN4 MYH9 CLDN1 TGFB1 LAMB2 CDKN1A LRP5 CDKN1B PAX2 ITGB3 CTSL LRP6 SCARB2 DKK1 ITGAV MKI67 KIRREL3 TRPC6 KIRREL2 WNT1 LIMS1 HEL113